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Sample records for battlefield phosgene poisoning

  1. Occupational phosgene poisoning: a case report and review.

    PubMed

    Wyatt, J P; Allister, C A

    1995-09-01

    Phosgene is a highly toxic gas to which some workers may be occupationally exposed. This case report demonstrates the possibility of refrigeration workers suffering phosgene poisoning after heating certain chlorinated fluorocarbons ('freons'). The need to suspect phosgene exposure and observe such patients is emphasized, especially in view of the delay in clinical deterioration observed in some patients who subsequently develop adult respiratory distress syndrome.

  2. Occupational phosgene poisoning: a case report and review.

    PubMed Central

    Wyatt, J P; Allister, C A

    1995-01-01

    Phosgene is a highly toxic gas to which some workers may be occupationally exposed. This case report demonstrates the possibility of refrigeration workers suffering phosgene poisoning after heating certain chlorinated fluorocarbons ('freons'). The need to suspect phosgene exposure and observe such patients is emphasized, especially in view of the delay in clinical deterioration observed in some patients who subsequently develop adult respiratory distress syndrome. PMID:8581252

  3. Phosgene

    MedlinePlus

    ... is a major industrial chemical used to make plastics and pesticides. At room temperature (70°F), phosgene ... head. If possible, seal the clothing in a plastic bag. Then seal the first plastic bag in ...

  4. Phosgene

    SciTech Connect

    Bast, Cheryl B; Glass-Mattie, Dana F

    2009-01-01

    Inhalation is the most important route of exposure for phosgene. A latency period occurs before phosgene affects the target organ, the lungs. The odor threshold is between 0.5 and 1.5 ppm, and the odor has been described as similar to newly-mown hay. Toxic effects have been reported at concentrations below the threshold. On initial exposure, phosgene can undergo hydrolysis and form hydrogen chloride which can be slightly irritating to the upper respiratory tract and eyes; the amount formed is limited by the low water solubility of phosgene. Once inhaled to the lower respiratory tract, phosgene undergoes an acylation reaction with amino, hydroxyl and sulfhydryl groups causing destruction of protein, lipids, and disruption of cellular functions. In response to this destruction, after a latency period of 1-24 hours, a breakdown in the blood-air barrier occurs and protein rich fluid accumulates in the lungs. Most commonly, death occurs within 48 hours after exposure from a progressive pulmonary edema and anoxia. At very high concentrations, death can occur from acute heart failure prior to the start of the pulmonary edema. Data on humans are limited to occupational exposures or accounts from the use of phosgene in World War I. Animal studies with phosgene show a steep dose-response curve for pulmonary edema and mortality. Animal studies also indicate little species variability as all species exposed developed similar clinical signs (dyspnea, pulmonary edema, labored breathing) and histopathological lesions in the lungs. While there are no chronic animal data, subchronic studies indicate little accumulation of phosgene or increased severity of lesions with continuous exposure.

  5. Phosgene

    Integrated Risk Information System (IRIS)

    Phosgene ; CASRN 75 - 44 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic Effects )

  6. Battlefield radiology

    PubMed Central

    Graham, R N J

    2012-01-01

    With the increasing tempo of military conflicts in the last decade, much has been learnt about imaging battlefield casualties in the acute setting. Ultrasound in the form of focused abdominal sonography in trauma (FAST) has proven invaluable in emergency triage of patients for immediate surgery. Multidetector CT allows accurate determination of battlefield trauma injuries. It permits the surgeons and anaesthetists to plan their interventions more thoroughly and to be made aware of clinically occult injuries. There are common injury patterns associated with blast injury, gunshot wounds and blunt trauma. While this body of knowledge is most applicable to the battlefield, there are parallels with peacetime radiology, particularly in terrorist attacks and industrial accidents. This pictorial review is based on the experiences of a UK radiologist deployed in Afghanistan in 2010. PMID:22806621

  7. IRIS TOXICOLOGICAL REVIEW OF PHOSGENE (2006 Final)

    EPA Science Inventory

    EPA is announcing the release of the final report, Toxicological Review of Phosgene: in support of the Integrated Risk Information System (IRIS). The updated Summary for Phosgene and accompanying Quickview have also been added to the IRIS Database.

  8. Attenuation of phosgene toxicity. Final report, 30 November 1992-30 September 1995

    SciTech Connect

    Currie, W.D.

    1995-10-01

    Certain inhaled toxins, e.g., phosgene and other oxidant gases, can trigger a debilitating and usually fatal form of respiratory distress. Presently, there is no antidote for such lung-damaging agents. We have completed a comprehensive examination of surfactant replacement therapy (SRT) as a counter-measure against these agents which damage the pulmonary surfactant system of the alveolar and respiratory bronchiolar airways. Exogenous pulmonary surfactant was administered either by intratracheal instillation or by aerosol to male Sprague-Dawley rats that had been exposed to 40.5 ppm phosgene gas for 10 minutes in a Cannon type (nose-only) chamber (the LCt50, 24-hour) in order to assess treatment effects on tissue edema, lung function and survival. Phosgene exposure was found to have an adverse effect on the surface activity of the endogenous pulmonary surfactant system in these exposed rats. Surfactant replacement helped to restore this activity. SRT did not prevent massive outpouring of edema water which marks the clinical phase of phosgene poisoning, nor did it alleviate the attending decline in lung function. Nonetheless, SRT was found to significantly reduce mortality from exposure to the toxin. Our findings suggest that SRT may be the first effective countermeasure for US military personnel following lethal phosgene exposure.

  9. Poisoning

    MedlinePlus

    ... gas heater and any other gas-, oil- or wood-fueled appliances serviced regularly. Be sure these appliances ... on the skin, rinse it off with running water and remove any poisoned clothing. If the poison ...

  10. Poisoning

    MedlinePlus

    ... talking with the Poison Control Center. GETTING HELP Call the Poison Control Center emergency number at 1-800-222-1222. DO NOT wait until the person has symptoms before you call. Try to have the following information ready: The ...

  11. COLCHICINE DECREASES AIRWAY HYPERACTIVITY AFTER PHOSGENE EXPOSURE

    EPA Science Inventory

    Phosgene (COCl(2)) exposure affects an influx of inflammatory cells into the lung, which can be reduced in an animal model by pretreatment with colchicine. Inflammation in the respiratory tract can be associated with an increase in airway hyperreactivity. We tested the hypotheses...

  12. PROVISIONAL ADVISORY LEVELS (PALs) FOR PHOSGENE (CG)

    SciTech Connect

    Glass-Mattie, Dana F; McClanahan, Mark; Koller, Loren; Adeshina, Femi; Ross, Robert Hord

    2009-01-01

    The PAL protocol was applied to estimate inhalation exposure limits for phosgene (CG). Data on humans are limited to occupational exposures or accounts from the use of phosgene as a chemical warfare agent in WWI. Animal studies with phosgene show a steep dose-response curve for pulmonary edema and mortality with little species variability in effects. Although immediately upon exposure lacrimation and upper respiratory irritation can occur, the main effect in the target organ, a progressive pulmonary edema, occurs after a latency period of 1-24 hours. PAL estimates were approved by the Expert Consultation Panel for Provisional Advisory Levels in May 2007. Exposure limits for oral exposure to CG are not developed due to insufficient data. PAL estimates for inhalation exposure to CG are presented: The 24-hour PAL values for severity levels 1, 2, and 3 are 0.0017, 0.0033 and 0.022 ppm, respectively. The 30-day PAL values are 0.0006 and 0.0012 ppm for the PAL 1 and 2 values, respectively. These 30-day inhalation values were also accepted as the 90-day and 2-year PAL 1 and 2 values. Data were not available for deriving 30-day, 90-day and 2-year PAL 3 values.

  13. Military Healthcare Battlefield Immunity.

    PubMed

    Kelly, J C

    2012-12-01

    The combatant soldier on the battlefield remains protected from any claim in negligence by the doctrine of combat immunity for any negligent act or omission they may make when fighting. In other words, the combatant soldier does not owe a fellow soldier a duty of care on the battlefield, as the duty of care is non-justiciable. However, the non-combatant Military Healthcare Professional, although sometimes operating in the same hostile circumstances as the fighting soldier, is unlikely to benefit from combat immunity for any clinical negligence on the battlefield. This is because they continue to owe their patient a duty of care, although this has not been tested in the courts. This paper considers if any military healthcare professional could ever benefit from combat immunity, which is unlikely due to their non-combatant status. Instead, this paper suggests that a modified form of immunity; namely, Military Healthcare Battlefield Immunity could be a new, unique and viable doctrine, however, this could only be granted in rare circumstances and to a much lesser degree than combat immunity.

  14. Method for removal of phosgene from boron trichloride

    DOEpatents

    Freund, Samuel M.

    1983-01-01

    Selective ultraviolet photolysis using an unfiltered mercury arc lamp has been used to substantially reduce the phosgene impurity in a mixture of boron trichloride and phosgene. Infrared spectrophotometric analysis of the sample before and after irradiation shows that is is possible to highly purify commercially available boron trichloride with this method.

  15. Method for removal of phosgene from boron trichloride

    DOEpatents

    Freund, S.M.

    1983-09-20

    Selective ultraviolet photolysis using an unfiltered mercury arc lamp has been used to substantially reduce the phosgene impurity in a mixture of boron trichloride and phosgene. Infrared spectrophotometric analysis of the sample before and after irradiation shows that it is possible to highly purify commercially available boron trichloride with this method. 5 figs.

  16. Battlefield agent collaboration

    NASA Astrophysics Data System (ADS)

    Budulas, Peter P.; Young, Stuart H.; Emmerman, Philip J.

    2001-09-01

    Small air and ground physical agents (robots) will be ubiquitous on the battlefield of the 21st century, principally to lower the exposure to harm of our ground forces in urban and open terrain scenarios. Teams of small collaborating physical agents conducting tasks such as Reconnaissance, Surveillance, and Target Acquisition (RSTA), intelligence, chemical and biological agent detection, logistics, decoy, sentry; and communications relay will have advanced sensors, communications, and mobility characteristics. It is anticipated that there will be many levels of individual and team collaboration between the soldier and robot, robot to robot, and robot to mother ship. This paper presents applications and infrastructure components that illustrate each of these levels. As an example, consider the application where a team of twenty small robots must rapidly explore and define a building complex. Local interactions and decisions require peer to peer collaboration. Global direction and information fusion warrant a central team control provided by a mother ship. The mother ship must effectively deliver/retrieve, service, and control these robots as well as fuse the information gathered by these highly mobile robot teams. Any level of collaboration requires robust communications, specifically a mobile ad hoc network. The application of fixed ground sensors and mobile robots is also included in this paper. This paper discusses on going research at the U.S. Army Research Laboratory that supports the development of multi-robot collaboration. This research includes battlefield visualization, intelligent software agents, adaptive communications, sensor and information fusion, and multi-modal human computer interaction.

  17. Lanolin poisoning

    MedlinePlus

    Wool wax poisoning; Wool alcohol poisoning; Glossylan poisoning; Golden dawn poisoning; Sparklelan poisoning ... Symptoms of lanolin poisoning include: Diarrhea Rash Swelling and redness of skin Vomiting

  18. Battlefield awareness computers: the engine of battlefield digitization

    NASA Astrophysics Data System (ADS)

    Ho, Jackson; Chamseddine, Ahmad

    1997-06-01

    To modernize the army for the 21st century, the U.S. Army Digitization Office (ADO) initiated in 1995 the Force XXI Battle Command Brigade-and-Below (FBCB2) Applique program which became a centerpiece in the U.S. Army's master plan to win future information wars. The Applique team led by TRW fielded a 'tactical Internet' for Brigade and below command to demonstrate the advantages of 'shared situation awareness' and battlefield digitization in advanced war-fighting experiments (AWE) to be conducted in March 1997 at the Army's National Training Center in California. Computing Devices is designated the primary hardware developer for the militarized version of the battlefield awareness computers. The first generation of militarized battlefield awareness computer, designated as the V3 computer, was an integration of off-the-shelf components developed to meet the agressive delivery requirements of the Task Force XXI AWE. The design efficiency and cost effectiveness of the computer hardware were secondary in importance to delivery deadlines imposed by the March 1997 AWE. However, declining defense budgets will impose cost constraints on the Force XXI production hardware that can only be met by rigorous value engineering to further improve design optimization for battlefield awareness without compromising the level of reliability the military has come to expect in modern military hardened vetronics. To answer the Army's needs for a more cost effective computing solution, Computing Devices developed a second generation 'combat ready' battlefield awareness computer, designated the V3+, which is designed specifically to meet the upcoming demands of Force XXI (FBCB2) and beyond. The primary design objective is to achieve a technologically superior design, value engineered to strike an optimal balance between reliability, life cycle cost, and procurement cost. Recognizing that the diverse digitization demands of Force XXI cannot be adequately met by any one computer hardware

  19. Petersburg National Battlefield Lesson Plans.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    This collection of eight lesson plans deals with the Petersburg (Virginia) U.S. Civil War battlefield. The lessons tell about slave life and plantation life in the U.S. south, and how the Civil War forever changed this structure. To do the lessons, students read primary source documents that tell the stories of three different soldiers who…

  20. Refrigerant poisoning

    MedlinePlus

    Coolant poisoning; Freon poisoning; Fluorinated hydrocarbon poisoning; Sudden sniffing death syndrome ... should call if you have any questions about poisoning or poison prevention. It does NOT need to ...

  1. Diazinon poisoning

    MedlinePlus

    Bazinon poisoning; Diazol poisoning; Gardentox poisoning; Knox-Out poisoning; Spectracide poisoning ... Below are symptoms of diazinon poisoning in different parts of the ... No breathing Bladder and kidneys: Increased urination Eyes, ...

  2. Malathion poisoning

    MedlinePlus

    Carbofos poisoning; Compound 4049 poisoning; Cythion poisoning; Fosfothion poisoning; Mercaptothion poisoning ... Below are symptoms of malathion poisoning in different parts of the ... No breathing Bladder and kidneys Increased urination Eyes, ...

  3. Health assessment of phosgene: approaches for derivation of reference concentration.

    PubMed

    Gift, Jeffrey S; McGaughy, Robert; Singh, Dharm V; Sonawane, Babasaheb

    2008-06-01

    This paper describes the derivation of the chronic reference concentration (RfC) for human inhalation of phosgene that was recently added to the Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) data base (U.S. EPA, 2005. Toxicological Review of Phosgene: In Support of Summary Information on the Integrated Risk Information System (IRIS). Available online at: ). The RfC is an estimate of daily phosgene exposure to the human population that is likely to be without appreciable risk of deleterious effects during a lifetime. [For this and other definitions relevant to EPA risk assessments refer to the glossary of terms in the US EPA IRIS website (http://www.epa.gov/IRIS).] Phosgene is a potential environmental pollutant that is primarily used as a catalyst in the polyurethane industry. It is a gas at room temperature, and in aqueous solution it rapidly hydrolyzes to CO2 and HCl. In the absence of chronic human health effects information and lifetime animal cancer bioassays, the RfC is based on two 12-week inhalation studies in F344 rats which measured immune response and pulmonary effects, respectively. The immune response study showed impaired clearance of bacteria that was administered into the lungs of rats immediately after exposure to phosgene at concentrations of 0.1, 0.2 and 0.5 ppm. It also showed that the immune response in uninfected rats was stimulated by phosgene exposure at all concentrations. The pulmonary effects study showed a progressive concentration-related thickening and inflammation in the bronchiolar regions of the lung that was mild at 0.1 ppm and severe at 1.0 ppm. An increase in collagen content, as observed with histological collagen stains, was observed at 0.2 ppm and above. Though there is considerable uncertainty associated with the species and exposure duration employed, this endpoint is considered an indication of chronic lung injury of potential relevance to humans. Three different

  4. PREVENTION REFERENCE MANUAL: CHEMICAL SPECIFIC, VOLUME 14: CONTROL OF ACCIDENTAL RELEASES OF PHOSGENE

    EPA Science Inventory

    The report, discussing phosgene, is one of a series addressing the prevention of accidental releases of toxic chemicals. Phosgene, a highly reactive and corrosive liquid that boils at room temperature has an Immediately Dangerous to Life and Health (lDLH) conctntration of 2 ppm, ...

  5. Method for removal of phosgene from boron trichloride. [DOE patent application; mercury arc lamp

    DOEpatents

    Freund, S.M.

    1981-09-03

    Selective ultraviolet photolysis using an unfiltered mercury arc lamp has been used to substantially reduce the phosgene impurity in a mixture of boron trichloride and phosgene. Infrared spectrophotometric analysis of the sample before and after irradiation shows that it is possible to highly purify commercially available boron trichloride with this method.

  6. Conceptual approaches for treatment of phosgene inhalation-induced lung injury.

    PubMed

    Holmes, Wesley W; Keyser, Brian M; Paradiso, Danielle C; Ray, Radharaman; Andres, Devon K; Benton, Betty J; Rothwell, Cristin C; Hoard-Fruchey, Heidi M; Dillman, James F; Sciuto, Alfred M; Anderson, Dana R

    2016-02-26

    Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civilian population in cases of accidental or intentional release. Several of these chemicals have no known medical countermeasures for their toxic effects. Phosgene is a highly toxic industrial chemical which was used as a chemical warfare agent in WWI. Exposure to phosgene causes latent, non-cardiogenic pulmonary edema which can result in respiratory failure and death. The mechanisms of phosgene-induced pulmonary injury are not fully identified, and currently there is no efficacious countermeasure. Here, we provide a proposed mechanism of phosgene-induced lung injury based on the literature and from studies conducted in our lab, as well as provide results from studies designed to evaluate survival efficacy of potential therapies following whole-body phosgene exposure in mice. Several therapies were able to significantly increase 24h survival following an LCt50-70 exposure to phosgene; however, no treatment was able to fully protect against phosgene-induced mortality. These studies provide evidence that mortality following phosgene toxicity can be mitigated by neuro- and calcium-regulators, antioxidants, phosphodiesterase and endothelin receptor antagonists, angiotensin converting enzymes, and transient receptor potential cation channel inhibitors. However, because the mechanism of phosgene toxicity is multifaceted, we conclude that a single therapeutic is unlikely to be sufficient to ameliorate the multitude of direct and secondary toxic effects caused by phosgene inhalation. PMID:26562770

  7. Pulmonary structural and extracellular matrix alterations in Fischer 344 rats following subchronic phosgene exposure.

    PubMed

    Kodavanti, U P; Costa, D L; Giri, S N; Starcher, B; Hatch, G E

    1997-05-01

    Phosgene, an acylating agent, is a very potent inducer of pulmonary edema. Subchronic effects of phosgene in laboratory animals are not well characterized. The purpose of the study was to elucidate potential long-term effects on collagen and elastin metabolism during pulmonary injury/recovery and obtain information about the concentration x time (C x T) behavior of low levels of phosgene. Male Fischer 344 rats (60 days old) were exposed either to clean air or phosgene, 6 hr/day: 0.1 ppm (5 days/week), 0.2 ppm (5 days/week), 0.5 ppm (2 days/week), and 1.0 ppm (1 day/week), for 4 or 12 weeks. A group of rats was allowed clean air recovery for 4 weeks after 12 weeks of phosgene exposure. This exposure scenario was designed to provide equal C x T product for all concentrations at one particular time point except for 0.1 ppm (50% C x T). Phosgene exposure for 4 or 12 weeks increased lung to body weight ratio and lung displacement volume in a concentration-dependent manner. The increase in lung displacement volume was significant even at 0.1 ppm phosgene at 4 weeks. Light microscopic level histopathology examination of lung was conducted at 0.0, 0.1, 0.2, and 1.0 ppm phosgene following 4 and 12 and 16 weeks (recovery). Small but clearly apparent terminal bronchiolar thickening and inflammation were evident with 0.1 ppm phosgene at both 4 and 12 weeks. At 0.2 ppm phosgene, terminal bronchiolar thickening and inflammation appeared to be more prominent when compared to the 0.1 ppm group and changes in alveolar parenchyma were minimal. At 1.0 ppm, extensive inflammation and thickening of terminal bronchioles as well as alveolar walls were evident. Concentration rather than C x T seems to drive pathology response. Trichrome staining for collagen at the terminal bronchiolar sites indicated a slight increase at 4 weeks and marked increase at 12 weeks in both 0.2 and 1.0 ppm groups (0.5 ppm was not examined), 1.0 ppm being more intense. Whole-lung prolyl hydroxylase activity and

  8. Paraffin poisoning

    MedlinePlus

    Wax poisoning - paraffin ... number will let you talk to experts in poisoning. They will give you further instructions. This is ... should call if you have any questions about poisoning or poison prevention. It does NOT need to ...

  9. Methanol poisoning

    MedlinePlus

    Wood alcohol poisoning ... number will let you talk to experts in poisoning. They will give you further instructions. This is ... should call if you have any questions about poisoning or poison prevention. You can call 24 hours ...

  10. Battlefield Optical Surveillance System (BOSS)

    NASA Astrophysics Data System (ADS)

    Ireland, Robert J.

    1997-02-01

    The battlefield optical surveillance system (BOSS) was developed for DARPA by the U.S. Air Force's Phillips Laboratory. BOSS is a HMMWV mounted laser surveillance and deterrence system. It is intended to be used to detect and to deter potentially hostile individuals, snipers and groups of agitators. The BOSS integrates the following: (1) a thermal camera (8-12 micrometer FLIR), that detects and cues to possible targets, (2) a 45 watt, 808 nm (near IR), air- cooled laser which provides covert illumination and designation for a day/night camera to acquire said target and attain a high-resolution image using night vision equipment, and (3) a 1 watt, 532 nm (green) laser that overtly illuminates and designates the target. It also has significant deterring effects both physiological and psychological on individuals and crowds. BOSS offers the potential capability to detect snipers before the first shot is fired. Detection of optical augmentations and the thermal characteristics of a sniper allows for this early detection. The integration of BOSS with acoustic sniper detection systems are being explored.

  11. Atmospheric chemistry of toxic contaminants 4. Saturated halogenated aliphatics: Methyl bromide, epichlorhydrin, phosgene

    SciTech Connect

    Grosjean, D. )

    1991-01-01

    Mechanisms are outlined for the reactions that contribute to in-situ formation and atmospheric removal of the saturated halogenated aliphatic contaminants methyl bromide, epichlorhydrin, and phosgene. In-situ formation is important only for phosgene and involves the reaction of OH with chloroethenes and other chlorinated hydrocarbons. A ranking of these phosgene precursors is given using data for precursor ambient concentrations and chemical reactivity. The three toxic compounds studied are long-lived in the atmosphere, where removal of phosgene and methyl bromide by chemical reactions is negligibly slow. Epichlorhydrin is removed slowly by reaction with OH, leading to formaldehyde, chloroacetaldehyde, and the chlorinated peroxyacyl nitrate CH{sub 2}ClC(O)OONO{sub 2}.

  12. Species comparison of acute inhalation toxicity of ozone and phosgene

    SciTech Connect

    Hatch, G.E.; Slade, R.; Stead, A.G.; Graham, J.A.

    1986-01-01

    A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) and phosgene (COCl/sub 2/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation toxicity studies. The effect of 4-h exposures to ozone at concentrations of 0.2, 0.5, 1.0, and 2.0 ppm, and to COCl/sub 2/ and 0.1, 0.2, 0.5, and 1.0 ppm was determined in rabbits, guinea pigs, rats, hamsters, and mice. Lavage fluid protein (LFP) accumulation 18-20 h after exposure was used as the indicator of O3- and COCl/sub 2/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 mg/ml) when a volume of saline that approximated the total lung capacity was used to lavage the collapsed lungs. Ozone effects were most marked in guinea pigs, which showed significant effects at 0.2 ppm and above. Mice, hamsters, and rats showed effects at 1.0 ppm O3 and above, while rabbits responded only at 2.0 ppm O3. Phosgene similarly affected mice, hamsters, and rats at 0.2 ppm and above, while guinea pigs and rabbits were affected at 0.5 ppm and above. Percent recovery of lavage fluid varied significantly between species, guinea pigs having lower recovery than other species with both gases. Lavage fluid recovery was lower following exposure to higher levels of O3 but not COCl/sub 2/. Results of this study indicate that significant species differences are seen in the response to low levels of O3 and COCl/sub 2/. These differences do not appear to be related in a simple manner to body weight.

  13. Kinetics and mechanism of phosgenation of aliphatic alcohols. V. Quantum-chemical investigation of the mechanism of the reaction of phosgene with methanol

    SciTech Connect

    Orlov, S.I.; Varnek, A.A.; Chimishkyan, A.L.; Sel', O.B.

    1988-04-20

    Analysis of maps of the molecular electrostatic potential of phosgene showed that attack by methanol as nucleophile at the phosgene carbon atom takes place preferentially not in the plane of the molecule (the S/sub N/2 mechanism) but in a direction perpendicular to the COCl/sub 2/ plane (an AE addition-elimination mechanism). A fragment of the potential energy surface for the reaction of phosgene with methanol was calculated by the MNDO method. The reaction takes place by an AE-like mechanism through a late transition state, which represents a four-membered ring. There is not local minimum at a point corresponding to a tetrahedral intermediate, and this is explained by the absence of factors which stabilize it.

  14. Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons.

    PubMed

    Nieuwenhuizen, M S; Groeneveld, F R

    2000-01-01

    The formation of phosgene During welding activities in an atmosphere containing chlorinated hydrocarbons was investigated. Four different chlorinated hydrocarbons were studied under laboratory conditions. Results are presented as time-averaged phosgene concentration in a total volume of 250 L of air being purged through a 52-L reaction vessel during 20 min. It was found that the formation of phosgene was in the order dichloromethane < Freon-22 < carbon tetrachloride < trichoroethylene. Local concentrations may be higher depending on dispersion phenomena. The interpretation in terms of occupational health was rather difficult because of the interaction with smoke particles and because of possible nonhomogeneous dispersion of phosgene around the workers. In the case of dichloromethane and carbon tetrachloride the short-term maximum allowable concentration (MAC) of phosgene was not attained at the respective MAC values of the chlorinated hydrocarbons themselves. In the case of trichloroethylene and Freon-22, however, the short-term MAC-value of phosgene was attained even when the concentration was still much below the respective MAC-values.

  15. Accidental phosgene gas exposure: A review with background study of 10 cases

    PubMed Central

    Vaish, Arvind Kumar; Consul, Shuchi; Agrawal, Avinash; Chaudhary, Shyam Chand; Gutch, Manish; Jain, Nirdesh; Singh, Mohit Mohan

    2013-01-01

    Here, authors present a review on clinical presentation and management of exposure of phosgene gas after reviewing the literature by searching with keywords phosgene exposure on Google, Cochrane, Embase and PubMed with a background of experience gained from 10 patients who were admitted to our institute after an accidental phosgene exposure in February 2011 nearby a city in India. Phosgene is a highly toxic gas, occupational workers may have accidental exposure. The gas can also be generated inadvertently during fire involving plastics and other chemicals and solvents containing chlorine, which is of concern to emergency responders. Phosgene inhalation may cause initially symptoms of respiratory tract irritation, patients feel fine thereafter, and then die of choking a day later because of build up of fluid in the lungs (delayed onset non-cardiogenic pulmonary edema). Phosgene exposure is associated with significant morbidity and mortality. Patients with a history of exposure should be admitted to the hospital for a minimum of 24 h for observation because of the potential for delayed onset respiratory failure and acute respiratory distress syndrome. PMID:24339660

  16. Battlefield euthanasia - courageous compassion or war crime?

    PubMed

    Neuhaus, Susan J

    2011-03-21

    Issues relating to voluntary euthanasia that are currently being debated by Australian society are distinctly different from those encountered by battlefield doctors. Doctors in war undertake to treat those affected by conflict; their participation in euthanasia challenges the profession's definition of "duty of care". Euthanasia must be distinguished from "triage" and medical withdrawal of care (which are decided within a medical facility where, although resources may be limited, comfort care can be provided in the face of treatment futility). Battlefield euthanasia is a decision made, often immediately after hostile action, in the face of apparently overwhelming injuries; there is often limited availability of pain relief, support systems or palliation that would be available in a civilian environment. The battlefield situation is further complicated by issues of personal danger, the immediacy of decision making and difficulties with distinguishing civilians from combatants. Regardless of the circumstances on a battlefield, doctors, whether they are civilians or members of a defence force, are subject to the laws of armed conflict, the special provisions of the Geneva Conventions and the ethical codes of the medical profession.

  17. Phosgene in the UTLS: seasonal and latitudinal variations from MIPAS observations

    NASA Astrophysics Data System (ADS)

    Valeri, Massimo; Carlotti, Massimo; Flaud, Jean-Marie; Raspollini, Piera; Ridolfi, Marco; Dinelli, Bianca Maria

    2016-09-01

    The Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) is a Fourier transform spectrometer that measured mid-infrared atmospheric limb emission spectra from July 2002 to April 2012 on board the polar-orbiting satellite ENVISAT. We have used MIPAS data to study the latitudinal variations of phosgene (COCl2 or carbonyl chloride) and, for the first time, its seasonal variation in the upper troposphere/lower stratosphere region (UTLS). Retrievals of phosgene were made using the 830-860 cm-1 region, corresponding to the ν5 bands of COCl2. Unfortunately, in that region, the ν4 band of CFC-11, which is much stronger than COCl2 ν5, hides the phosgene emission. In order to evaluate seasonality and latitudinal distribution of phosgene we have analysed all the measurements made by MIPAS on days 18 and 20 of each month of 2008 with the optimized retrieval model (ORM) recently upgraded with the multi-target retrieval technique and with the optimal estimation functionality to apply external constraints to the state vector. Average seasonal profiles of phosgene show an evident latitudinal variability with the largest values observed in the tropical regions (maximum ≈ 35 parts per trillion by volume (pptv) at about 300 hPa). In the midlatitude and polar regions, the volume mixing ratio (VMR) values do not exceed 30 pptv and the vertical distributions are less peaked. Our analysis highlights that COCl2 seasonal variability is fairly low, apart from the polar regions.

  18. Lead Poisoning

    MedlinePlus

    ... Experiments Stories Lessons Topics Games Activities Lessons MENU Lead Poisoning Kids Homepage Topics Pollution Lead Poisoning What is ... you can avoid contact with it! Sources of Lead Poisoning HOUSE PAINTS: Before1950, lead-based paint was used ...

  19. Lead Poisoning

    MedlinePlus

    Lead Poisoning What is it and who is affected? Lead is a highly toxic substance, exposure to which ... and children can suffer from the effects of lead poisoning, but childhood lead poisoning is much more frequent. ...

  20. Acetone poisoning

    MedlinePlus

    Dimethyl formaldehyde poisoning; Dimethyl ketone poisoning; Nail polish remover poisoning ... Acetone can be found in: Nail polish remover Some cleaning solutions Some glues, including rubber cement Some lacquers Other products may also contain acetone.

  1. Fiber-optic microphones for battlefield acoustics.

    PubMed

    Wooler, John P F; Crickmore, Roger I

    2007-05-01

    We describe recent work to evaluate the potential performance of an interferometric fiber-optic microphone for battlefield acoustics. The microphone design has high sensitivity and flat response at low frequency and is readily multiplexed. The design is simple and could be manufactured at low cost, which is desirable since in operation the sensors may need to be disposable. Field trial results from an array of microphones are discussed. PMID:17429460

  2. Fiber-optic microphones for battlefield acoustics

    NASA Astrophysics Data System (ADS)

    Wooler, John P. F.; Crickmore, Roger I.

    2007-05-01

    We describe recent work to evaluate the potential performance of an interferometric fiber-optic microphone for battlefield acoustics. The microphone design has high sensitivity and flat response at low frequency and is readily multiplexed. The design is simple and could be manufactured at low cost, which is desirable since in operation the sensors may need to be disposable. Field trial results from an array of microphones are discussed.

  3. PHOSGENE AS AN EXAMPLE OF THE C X T TOXICITY PRINCIPLE: THE ROLE OF ADAPTATION

    EPA Science Inventory

    Phosgene as an example of the C x T toxicity principle: the role of adaptation

    Name/Title : Dr. Gary E. Hatch
    Organization: Pulmonary Toxicology Branch, Experimental Toxicology Division, NHEERL, EPA, RTP
    Mailing Address: Mail Drop 82, US EPA, Res. Tri. Park, NC 27...

  4. AN "INJURY-TIME INTEGRAL" MODEL FOR RELATING ACUTE TO CHRONIC INJURY TO PHOSGENE

    EPA Science Inventory


    ABSTRACT
    The present study compares acute and subchronic episodic exposures to phosgene to test the applicability of the "concentration x time" (C x T) product as a measure of exposure dose, and to relate acute toxicity and adaptive responses to chronic toxicity. Rats (m...

  5. 36 CFR 7.64 - Petersburg National Battlefield.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... vehicle is prohibited, except with the written permission of the Superintendent. (b) Maintenance of..., building, road, picnic area, parking space, or other portion of Petersburg National Battlefield to...

  6. 36 CFR 7.64 - Petersburg National Battlefield.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... vehicle is prohibited, except with the written permission of the Superintendent. (b) Maintenance of..., building, road, picnic area, parking space, or other portion of Petersburg National Battlefield to...

  7. 36 CFR 7.64 - Petersburg National Battlefield.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... vehicle is prohibited, except with the written permission of the Superintendent. (b) Maintenance of..., building, road, picnic area, parking space, or other portion of Petersburg National Battlefield to...

  8. 36 CFR 7.64 - Petersburg National Battlefield.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... vehicle is prohibited, except with the written permission of the Superintendent. (b) Maintenance of..., building, road, picnic area, parking space, or other portion of Petersburg National Battlefield to...

  9. Foxglove poisoning

    MedlinePlus

    Foxglove poisoning most often occurs from sucking the flowers or eating the seeds, stems, or leaves of ... The poisonous substances are found in: Flowers, leaves, stems, and seeds of the foxglove plant Heart medicine (digitalis glycoside)

  10. Ethanol poisoning

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002644.htm Ethanol poisoning To use the sharing features on this page, please enable JavaScript. Ethanol poisoning is caused by drinking too much alcohol. ...

  11. Starch poisoning

    MedlinePlus

    Cooking starch poisoning; Laundry starch poisoning ... Cooking and laundry starch are both made from vegetable products, most commonly: Corn Potatoes Rice Wheat Both are usually considered nonpoisonous (nontoxic), but ...

  12. Poisonous Plants

    MedlinePlus

    ... Publications and Products Programs Contact NIOSH NIOSH POISONOUS PLANTS Recommend on Facebook Tweet Share Compartir Photo courtesy ... U.S. Department of Agriculture Many native and exotic plants are poisonous to humans when ingested or if ...

  13. Copper poisoning

    MedlinePlus

    ... Poisoning and Drug Overdose . 4th ed. Philadelphia, PA: Elsevier Saunders; 2007:chap 75. Holland MG. Pulmonary toxicology. ... Poisoning and Drug Overdose . 4th ed. Philadelphia, PA: Elsevier Saunders; 2007:chap 9. Jones AL, Dargan PI. ...

  14. Smart ammunition behavior in a virtual battlefield

    NASA Astrophysics Data System (ADS)

    Gozard, Patrick; Cathala, Thierry; Latger, Jean

    2006-05-01

    To perform multi-sensors simulations, the French DGA/DET (Directorate for Technical Evaluation of the French Ministry of Defense) uses CHORALE (simulated Optronic Acoustic Radar battlefield). CHORALE enables the user to create virtual and realistic multi spectral 3D scenes, and generate the physical signal received by a sensor, typically an IR sensor. This article presents how the expertise is made to evaluate smart ammunition with laser guidance in a virtual battlefield with the environment CHORALE and the workshop AMOCO. The scene includes background, targets, a laser to designate and ammunition. The laser source is reflected by a target in the battlefield and the laser receiver is linked with ballistics model and guidance model via a simulation framework. Each tool is explained to understand the physics phenomena in the scene to take into account atmospheric transmission, radiative parameters of objects and counter-measure devices. Then numeric models are described as the different ballistics models 3 DOF or 6 DOF, sensor model. The step of ballistics calculation gives the cadence of the global simulation through the simulation framework. The 4 quadrants sensor provides gap between the center of optical way and the barycentre of the spot on the sensitive surface computed by a spot weighted method. These data are provided to the guidance and ballistics model to calculate a new position and a new view of the scene with the designated target in the field view. Finally, this paper explains some results of the evaluation compared with the true behavior after tests on proving ground. Then future evolutions are presented to perform similar evaluation with other intelligent ammunition in a real-time model.

  15. Carbolic acid poisoning

    MedlinePlus

    Phenol poisoning; Phenylic acid poisoning; Hydroxybenzene poisoning; Phenic acid poisoning; Benzenol poisoning ... Below are symptoms of carbolic acid poisoning in different parts of the ... urine Decreased urine output No urine output EYES, EARS, ...

  16. Sodium carbonate poisoning

    MedlinePlus

    Sal soda poisoning; Soda ash poisoning; Disodium salt poisoning; Carbonic acid poisoning; Washing soda poisoning ... number will let you talk to experts in poisoning. They will give you further instructions. This is ...

  17. Battlefield Tours and Staff Rides: A Useful Learning Experience?

    ERIC Educational Resources Information Center

    Lloyd, Nick

    2009-01-01

    A key component of current British military education is the battlefield tour and staff ride. These tours allow students to visit the location of military events, most commonly the battlefields of the First and Second World Wars in northern Europe, to facilitate their understanding of military history and draw contemporary parallels from the…

  18. River as a part of ground battlefield

    NASA Astrophysics Data System (ADS)

    Vračar, Miodrag S.; Pokrajac, Ivan; Okiljević, Predrag

    2013-05-01

    The rivers are in some circumstances part of the ground battlefield. Microseisms induced at the riverbed or ground at the river surrounding might be consequence of military activities (military ground transports, explosions, troop's activities, etc). Vibrations of those fluid-solid structures are modeled in terms of solid displacement and change of fluid pressure. This time varying fluid pressure in river, which originates from ground microseisms, is possible to detect with hydrophones. Therefore, hydroacoustic measurements in rivers enables detecting, identification and localization various types of military noisy activities at the ground as and those, which origin is in the river water (hydrodynamics of water flow, wind, waves, river vessels, etc). In this paper are presented river ambient noise measurements of the three great rivers: the Danube, the Sava and the Tisa, which flows in north part of Serbia in purpose to establish limits in detection of the ground vibrations in relatively wide frequency range from zero to 20 kHz. To confirm statement that the river is a part of ground battlefield, and that hydroacoustic noise is possible to use in detecting and analyzing ground microseisms induced by civil or military activities, some previous collected data of hydroacoustic noise measurement in the rivers are used. The data of the river ambient noise include noise induced by civil engineering activities, that ordinary take place in large cities, noise that produced ships and ambient noise of the river when human activities are significantly reduced. The poly spectral method was used in analysis such events.

  19. Automated military unit identification in battlefield simulation

    SciTech Connect

    Stroud, P.; Gordon, R.

    1997-05-01

    It is the nature of complex systems, composed of many interacting elements, that unanticipated phenomena develop. Computer simulation, in which the elements of a complex system are implemented as interacting software objects (actors), is an effective tool to study collective and emergent phenomena in complex systems. A new cognitive architecture is described for constructing simulation actors that can, like the intelligent elements they represent adapt to unanticipated conditions. This cognitive architecture generates trial behaviors, estimates their fitness using an internal representation of the system, and has an internal apparatus for evolving a population of trial behaviors to changing environmental conditions. A specific simulation actor is developed to evaluate surveillance radar images of moving vehicles on battlefields. The vehicle cluster location, characterization and discrimination processes currently performed by intelligent human operators were implemented into a parameterized formation recognition process by using a newly developed family of 2D cluster filters. The mechanics of these cluster filters are described. Preliminary results are presented in which this GSM actor demonstrates the ability not only to recognize military formations under prescribed conditions, but to adapt its behavior to unanticipated conditions that develop in the complex simulated battlefield system.

  20. Black nightshade poisoning

    MedlinePlus

    Nightshade poisoning; Morelle noire poisoning; Wonderberry poisoning ... Black nightshade poisoning can affect many areas of the body. EYES, EARS, NOSE, MOUTH, AND THROAT Dry mouth Enlarged (dilated) pupils ...

  1. Blue nightshade poisoning

    MedlinePlus

    Bittersweet poisoning; Bitter nightshade poisoning; Scarlet berry poisoning; Weedy nightshade poisoning ... slow Shock LUNGS Slow breathing NERVOUS SYSTEM Delirium Fever Hallucinations Headache Loss of sensation Paralysis WHOLE BODY ...

  2. A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic.

    PubMed

    Zhou, Xin; Zeng, Yiying; Liyan, Chen; Wu, Xue; Yoon, Juyoung

    2016-04-01

    The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way. PMID:26938275

  3. Pulmonary pathological alterations in sheep exposed to a lethal dose of phosgene

    SciTech Connect

    Assaad, A.; Nold, J.; Petrali, J.; Moore, D.; Mitcheltree, L.; Corcoran, K.; Phillips, K. )

    1991-03-11

    In this study, the authors demonstrated the acute pulmonary cellular changes associated with phosgene exposure, by both light (L.M.) and electron microscopy (E.M.). Adult, unanesthetized sheep were exposed for 10 minutes to either 767 ppm/min of phosgene or room air. Four hours post exposure, all animals were killed, wet lung weight was obtained, and lung tissue was collected for L.M. and E.M. In sheep exposed to phosgene, wet lung weight was significantly higher. Grossly, the lung was congested and edematous. Alveolar and interstitial edema, fibrin and neutrophil exudation in the air spaces, and increased alveolar macrophages, were prominent by L.M. E.M. of Type I pneumocytes showed intracellular swelling, necrosis, and denuding of basement membrane with preservation of the tight junctions. Type II pneumocytes showed loss of lamellar bodies, cytoplasmic swelling, and damage to the endoplasmic reticulum. Endothelial cells showed increased density and vesicular activity, cytoplasmic swelling, and displacement of basement membrane. This study supports the biochemical data the authors previously reported.

  4. Poisonous plants.

    PubMed

    Kellerman, T S

    2009-03-01

    South Africa is blessed with one of the richest floras in the world, which--not surprisingly--includes many poisonous plants. Theiler in the founding years believed that plants could be involved in the aetiologies of many of the then unexplained conditions of stock, such as gousiekte and geeldikkop. His subsequent investigations of plant poisonings largely laid the foundation for the future Sections of Toxicology at the Institute and the Faculty of Veterinary Science (UP). The history of research into plant poisonings over the last 100 years is briefly outlined. Some examples of sustained research on important plant poisonings, such as cardiac glycoside poisoning and gousiekte, are given to illustrate our approach to the subject and the progress that has been made. The collation and transfer of information and the impact of plant poisonings on the livestock industry is discussed and possible avenues of future research are investigated.

  5. MEDEVAC: critical care transport from the battlefield.

    PubMed

    Higgins, R A

    2010-01-01

    In current military operations, the survival rates of critically injured casualties are unprecedented. An often hidden aspect of casualty care is safe transport from the point of injury to a field hospital and subsequently on to higher levels of care. This en route critical care, which is provided by flight medics under the most austere and rigorous conditions, is a crucial link in the care continuum. This article introduces the role and capabilities of US Army MEDEVAC and reflects the author's recent experience in Afghanistan as a flight medic. This article provides an assessment of the operational issues, medical capabilities, and transport experiences to provide a real-world view of critical care transport from the battlefield. The MEDEVAC helicopter environment is one of the most difficult, if not the most demanding, critical care environments. This overview brings to light a small but important piece of the care continuum.

  6. A Framework for Intelligent Battlefield Treatment System

    NASA Astrophysics Data System (ADS)

    Yu, Jian; Wu, Biao; Yi, Renjie; Zhu, Jie

    With the development of high technology weapon, the execution and precision of weapon have made great improvement, which arouse many new challenge for treatment of war wounds. It is very urgent to research how to reduce casualty of individual solider. However, researches focus only on daily application recently. This paper discusses Intelligent Battlefield Treatment System (IBTS), and designs the framework of the service-oriented system based on WCF. The system has the following functions: testing the physical condition of a solider, disposing the distress signals intelligently, dispatching rescuers and assisting self-rescue or mutual-rescue to the wounded. The IBTS characteristics of data aggregate, multi-platform operation and data sharing can improve the treatment efficiency.

  7. Stonefish poisoning.

    PubMed

    Lyon, Richard Mark

    2004-01-01

    Scuba diving is becoming an increasingly popular recreation. Divers are traveling further afield, often to remote dive locations. These locations are often home to poisonous marine creatures such as stonefish. A case of acute stonefish poisoning in a scuba diver is described, including his treatment, the difficulties encountered with his management and evacuation, and his subsequent return to full health. The proper management of stonefish poisoning is reviewed, and the implications for divers traveling to remote locations are given.

  8. Outsmarting Poison Ivy and Other Poisonous Plants

    MedlinePlus

    ... Consumer Updates Outsmarting Poison Ivy and Other Poisonous Plants Share Tweet Linkedin Pin it More sharing options ... hang in loose clusters. back to top Poison Plant Rashes Aren’t Contagious Poison ivy and other ...

  9. Jerusalem cherry poisoning

    MedlinePlus

    Christmas cherry poisoning; Winter cherry poisoning; Ground cherry poisoning ... The effects of Jerusalem cherry poisoning mostly affect the primarily gastrointestinal (often delayed 8 to10 hours), and central nervous system. This type of poisoning can be very ...

  10. Trauma management on the battlefield: a modern approach.

    PubMed

    Hawley, A

    1996-10-01

    With the development of British Army doctrine it is necessary to review the concepts underlying medical support to the modern battlefield. In particular, the provision of timely and balanced resuscitation to the high intensity battle is an issue requiring an understanding of both the tactical and the clinical demands. The wholesale application of civilian techniques and approaches to trauma management is not possible given the austerity of the battlefield clinical environment. The commitment to excellence and quality of care implicit in modern mainstream practice is of continuing relevance to the battlefield. A doctrinal approach involving the definition of desired clinical outcome and the constraints of operational feasibility, is proposed. Specifically, the introduction of a triad approach to trauma management is offered. The triad comprises readily available Battlefield Advanced Trauma Life Support (BATLS) skills, Surgical Resuscitation deployed forward and the provision of Field Intensive Care. Such an approach would marry together the clinically ideal with the tactically.

  11. Effective Strategy for Colorimetric and Fluorescence Sensing of Phosgene Based on Small Organic Dyes and Nanofiber Platforms.

    PubMed

    Hu, Ying; Chen, Liyan; Jung, Hyeseung; Zeng, Yiying; Lee, Songyi; Swamy, Kunemadihalli Mathada Kotraiah; Zhou, Xin; Kim, Myung Hwa; Yoon, Juyoung

    2016-08-31

    Three o-phenylendiamine (OPD) derivatives, containing 4-chloro-7-nitrobenzo[c][1,2,5]oxadiazole (NBD-OPD), rhodamine (RB-OPD), and 1,8-naphthalimide (NAP-OPD) moieties, were prepared and tested as phosgene chemosensors. Unlike previously described methods to sense this toxic agent, which rely on chemical processes that transform alcohols and amines to respective phosphate esters and phosphoramides, the new sensors operate through a benzimidazolone-forming reaction between their OPD groups and phosgene. These processes promote either naked eye visible color changes and/or fluorescence intensity enhancements in conjunction with detection limits that range from 0.7 to 2.8 ppb. NBD-OPD and RB-OPD-embedded polymer fibers, prepared using the electrospinning technique, display distinct color and fluorescence changes upon exposure to phosgene even in the solid state. PMID:27498559

  12. Kinetics and mechanism of phosgenation of aliphatic alcohols. VI. The role of the association of the alcohol

    SciTech Connect

    Orlov, S.I.; Chimishkyan, A.L.; Negrebetskii, V.V.

    1988-07-10

    Investigation of the effect of the association of a series of alcohols on the phosgenation rate in heptane showed that the tetramer of the alcohol enters exclusively into reaction with phosgene. This is explained by the formation of a bicyclic transition state (or tetrahedral intermediate), which does not require previous desolvation or association of the alcohol and secures effective intramolecular assistance to the elimination of hydrogen chloride. The electronic structure was determined by CNDO/2 quantum-chemical calculations, which reproduces the three-dimensional structure and electron density distribution in the molecules fairly well. Methanol was chosen as model alcohol in order to simplify the calculations.

  13. Detergent poisoning

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002777.htm Detergent poisoning To use the sharing features on this page, please enable JavaScript. Detergents are powerful cleaning products that may contain strong ...

  14. Wax poisoning

    MedlinePlus

    Crayons poisoning ... This ingredient is found in: Crayons Candles Canning wax Note: This list may not be all-inclusive. ... If a child eats a small amount of crayon, the wax will pass through the child's system ...

  15. Pokeweed poisoning

    MedlinePlus

    ... highest amounts of poison are found in the roots, leaves, and stems. Small amounts are in the ... is no guarantee that they are safe. The roots should never be eaten. Symptoms most often appear ...

  16. Yew poisoning

    MedlinePlus

    ... poisoning occurs when someone eats pieces of this plant. This article is for information only. DO NOT use it ... information: Person's age, weight, and condition Name and part of the plant that was swallowed, if known Time it was ...

  17. Gasoline poisoning

    MedlinePlus

    The poisonous ingredients in gasoline are chemicals called hydrocarbons, which are substances that contain only hydrogen and ... Lee DC. Hydrocarbons. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 8th ...

  18. Lacquer poisoning

    MedlinePlus

    Poisoning from lacquers is due to hydrocarbons, which are substances that contain only hydrogen and carbon. ... Lee DC. Hydrocarbons. In: Marx JA, Hockberger RS, Walls RM, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 8th ed. Philadelphia, ...

  19. Menthol poisoning

    MedlinePlus

    Menthol is used to add peppermint flavor to candy and other products. It is also used in certain skin lotions and ointments. This article discusses menthol poisoning from swallowing pure menthol. This article is ...

  20. Food poisoning

    MedlinePlus

    ... at picnics, school cafeterias, large social functions, or restaurants. When germs get into the food, it is ... an unsafe way during preparation in grocery stores, restaurants, or homes. Food poisoning can occur after eating ...

  1. Mistletoe poisoning

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002883.htm Mistletoe poisoning To use the sharing features on this page, please enable JavaScript. Mistletoe is an evergreen plant with white berries. Mistletoe ...

  2. Merthiolate poisoning

    MedlinePlus

    ... once widely used as germ-killer and a preservative in many different products, including vaccines. Merthiolate poisoning ... the throat (endoscopy) to see burns in the food pipe (esophagus) and stomach Chest x-ray EKG ( ...

  3. Shaving cream poisoning

    MedlinePlus

    Shaving lotion poisoning ... number will let you talk to experts in poisoning. They will give you further instructions. This is ... should call if you have any questions about poisoning or poison prevention. It does NOT need to ...

  4. Lip moisturizer poisoning

    MedlinePlus

    Chapstick poisoning ... number will let you talk to experts in poisoning. They will give you further instructions. This is ... should call if you have any questions about poisoning or poison prevention. It does NOT need to ...

  5. Photographic fixative poisoning

    MedlinePlus

    Photographic developer poisoning; Hydroquinone poisoning; Quinone poisoning; Sulfite poisoning ... Hydroquinones Quinones Sodium thiosulfate Sodium sulfite/bisulfite Boric acid Photographic fixative can also break down (decompose) to form sulfur dioxide gas.

  6. Management of Battlefield Injuries to the Skull Base.

    PubMed

    Stevens, Jayne R; Brennan, Joseph

    2016-10-01

    High velocity skull base injuries on the battlefield are unique in comparison to most civilian sector trauma. With more than 43,000 United States military personnel injuries during Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF), the most recent conflicts in Iraq and Afghanistan have significantly expanded the understanding of the physiology of modern battlefield trauma and how to appropriately address these injuries. The acute care principles of effective triage, airway management, and hemorrhage control in these injuries can be life saving and are reviewed here. Specific injury patterns and battlefield examples are reviewed as well, with a review of some of the lessons learned while providing care in a deployed setting. Utilization of the knowledge learned in Iraq and Afghanistan, which have improved casualty care of deployed service members, can be used both in future military conflicts and in civilian trauma care. PMID:27648400

  7. Military clouds: utilization of cloud computing systems at the battlefield

    NASA Astrophysics Data System (ADS)

    Süleyman, Sarıkürk; Volkan, Karaca; İbrahim, Kocaman; Ahmet, Şirzai

    2012-05-01

    Cloud computing is known as a novel information technology (IT) concept, which involves facilitated and rapid access to networks, servers, data saving media, applications and services via Internet with minimum hardware requirements. Use of information systems and technologies at the battlefield is not new. Information superiority is a force multiplier and is crucial to mission success. Recent advances in information systems and technologies provide new means to decision makers and users in order to gain information superiority. These developments in information technologies lead to a new term, which is known as network centric capability. Similar to network centric capable systems, cloud computing systems are operational today. In the near future extensive use of military clouds at the battlefield is predicted. Integrating cloud computing logic to network centric applications will increase the flexibility, cost-effectiveness, efficiency and accessibility of network-centric capabilities. In this paper, cloud computing and network centric capability concepts are defined. Some commercial cloud computing products and applications are mentioned. Network centric capable applications are covered. Cloud computing supported battlefield applications are analyzed. The effects of cloud computing systems on network centric capability and on the information domain in future warfare are discussed. Battlefield opportunities and novelties which might be introduced to network centric capability by cloud computing systems are researched. The role of military clouds in future warfare is proposed in this paper. It was concluded that military clouds will be indispensible components of the future battlefield. Military clouds have the potential of improving network centric capabilities, increasing situational awareness at the battlefield and facilitating the settlement of information superiority.

  8. Immunological battlefield in gastric cancer and role of immunotherapies

    PubMed Central

    Wang, Minyu; Busuttil, Rita A; Pattison, Sharon; Neeson, Paul J; Boussioutas, Alex

    2016-01-01

    Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient’s immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an “us against them” model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy – the tumour cell.

  9. Immunological battlefield in gastric cancer and role of immunotherapies.

    PubMed

    Wang, Minyu; Busuttil, Rita A; Pattison, Sharon; Neeson, Paul J; Boussioutas, Alex

    2016-07-28

    Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient's immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an "us against them" model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy - the tumour cell. PMID:27605873

  10. Arsenic poisoning.

    PubMed

    Schoolmeester, W L; White, D R

    1980-02-01

    Arsenic poisoning continues to require awareness of its diverse clinical manifestations. Industry is the major source of arsenic exposure. Although epidemiologic studies strongly contend that arsenic is carcinogenic, there are little supportive research data. Arsenic poisoning, both acute and chronic, is often overlooked initially in the evaluation of the patient with multisystem disease, but once it is suspected, many accurate methods are available to quantitate the amount and duration of exposure. Treatment with dimercaprol remains the mainstay of therapy, and early treatment is necessary to prevent irreversible complications.

  11. Scombroid Poisoning

    PubMed Central

    Lerke, Peter A.; Werner, S. Benson; Taylor, Stephen L.; Guthertz, Linda S.

    1978-01-01

    An outbreak of scombroid poisoning occurred in San Francisco in the fall of 1977. The vehicle was sashimi prepared from spoiled tuna fish. Prompt public health measures prevented further consumption of the implicated food. Laboratory studies showed the presence in the tuna of bacterial species capable of producing large amounts of histamine, a substance strongly implicated in scombroid poisoning. Chemical analysis showed that histamine is very unevenly distributed in the flesh of spoiling tuna, therefore accounting for the sometimes random occurrence of disease among people eating the same food at the same table. PMID:569397

  12. An 'injury-time integral' model for extrapolating from acute to chronic effects of phosgene.

    PubMed

    Hatch, G; Kodavanti, U; Crissman, K; Slade, R; Costa, D

    2001-06-01

    The present study compares acute and subchronic episodic exposures to phosgene to test the applicability of the 'concentrationxtime' (CxT) product as a measure of exposure dose, and to relate acute toxicity and adaptive responses to chronic toxicity. Rats (male Fischer 344) were exposed (six hours/day) to air or 0.1, 0.2, 0.5 and 1.0 ppm of phosgene one time or on a repeated regimen for up to 12 weeks as follows: 0.1 ppm (five days/week), 0.2 ppm (five days/week), 0.5 ppm (two days/week), or 1.0 ppm (one day/week) (note that the CxT for the three highest exposures was the same). Animals were sacrificed at 4, 8, and 12 weeks during the exposure and after four weeks recovery. Bronchoalveolar lavage (BAL) was performed 18 hours after the last exposure for each time period and the BAL supernatant assayed for protein. Elevated BAL fluid protein was defined as 'acute injury', diminished response after repeated exposure was defined as 'adaptation', and increased lung hydroxyproline or trichrome staining for collagen was defined as 'chronic injury'. Results indicated that exposures that cause maximal chronic injury involve high exposure concentrations and longer times between exposures, not high CxT products. A conceptual model is presented that explains the lack of CxT correlation by the fact that adaptation reduces an 'injury-time integral' as phosgene exposure is lengthened from acute to subchronic. At high exposure concentrations, the adaptive response appears to be overwhelmed, causing a continued injury-time integral, which appears to be related to appearance of chronic injury. The adaptive response is predicted to disappear if the time between exposures is lengthened, leading to a continued high injury-time integral and chronic injury. It has generally been assumed that long, continuous exposures of rodents is a conservative approach for detecting possible chronic effects. The present study suggests that such an approach my not be conservative, but might actually

  13. Poison Ivy

    MedlinePlus

    ... poison ivy”. The plant is found around the world, but it usually doesn’t grow in the desert or in high elevations. It usually grows in clusters in the woods, up in trees, and on the ground. Every part of the ...

  14. Paradichlorobenzene poisoning

    MedlinePlus

    ... level of alertness). Before Calling Emergency Have this information ready: Person's age, weight, and condition (for example, is the person awake or alert?) Name of the product Time it was swallowed Amount swallowed However, DO NOT delay calling ... Poison Control Your local ...

  15. Lead poisoning

    SciTech Connect

    Rekus, J.F.

    1992-08-01

    Construction workers who weld, cut or blast structural steel coated with lead-based paint are at significant risk of lead poisoning. Although technology to control these exposures may not have existed when the lead standard was promulgated, it is available today. Employers who do not take steps to protect their employees from lead exposure may be cited and fined severely for their failure.

  16. Antifreeze poisoning

    MedlinePlus

    ... breathing machine Chest x-ray CT scan (advanced brain imaging) EKG (electrocardiogram or heart tracing) Intravenous fluids (through a vein) Medicines to reverse the effects of the poison Tube placed ... Sometimes the person will need it for the rest of their life.

  17. Poison Prevention

    MedlinePlus

    ... Word Shop AAP Find a Pediatrician Safety & Prevention ... Content Article Body Post the Poison Help number 1-800-222-1222 on the emergency list next to every phone in your home and in your cell phone. A toddler or preschooler who vomits may ...

  18. Poison Ivy

    MedlinePlus

    ... ground. It is usually found in groups of many plants and looks like weeds growing from 6 inches ... or anything else that may have touched the plant (like camping, sporting, fishing or hunting gear). If you develop a poison ivy rash, it will go away on its own in 1 to 3 ...

  19. Hearts and Minds: Military Recruitment and the High School Battlefield

    ERIC Educational Resources Information Center

    Ayers, William

    2006-01-01

    In recent years, military recruitment has failed, with rare exceptions, to meet its quotas. The nations's high schools have thus become battlefields for the hearts and minds of young people as recruiters dangle gifts and promises of future benefits before teenagers in an effort to fill the ranks of an all-volunteer military. In this article, the…

  20. A method for near real time continuous air monitoring of phosgene, hydrogen cyanide, and cyanogen chloride

    SciTech Connect

    Lattin, F.G.; Paul, D.G.

    1996-12-31

    A sorbent-based gas chromatographic method provides continuous quantitative measurement of phosgene, hydrogen cyanide, and cyanogen chloride in ambient air. These compounds are subject to workplace exposure limits as well as regulation under terms of the Chemical Arms Treaty and Title III of the 1990 Clean Air Act amendments. The method was developed for on-site use in a mobile laboratory during remediation operations. Incorporated into the method are automated multi-level calibrations at time weighted average (TW) concentrations, or lower. Gaseous standards are prepared in fused silica lined air sampling canisters, then transferred to the analytical system through dynamic spiking. Precision and accuracy studies performed to validate the method are described. Also described are system deactivation and passivation techniques critical to optimum method performance.

  1. View the information-based battlefield environment system from network-centric warfare (NCW)

    NASA Astrophysics Data System (ADS)

    Zhang, Chengbin; You, Xiong

    2007-06-01

    Battlefield environment is a general designation for all kinds of objective things and conditions which surround battlefield and affect military actions. With the development of modern high technology, and information technology, traditional battlefield environment is developing in the both factors of space and constitutive, and takes on an integrated tendency. The U.S. military consider that the war of information age is NCW, and to successfully implement the theory of the NCW capabilities, the four domains of warfare-physical, information, cognitive, social, and their relationship must be understood. According to the theory of system, this paper puts forward the conception of Battlefield Environment System and its tetrahedron structure. The correlation of constitutive factors in Generalized Battlefield Environment System and the relationship between Generalized Battlefield Environment System and NCW are analyzed. Moreover, the spatial scope and constitutive factors of Specific Battlefield Environment System are also discussed.

  2. [Superwarfarine Poisoning].

    PubMed

    Freixo, Ana; Lopes, Luís; Carvalho, Manuela; Araújo, Fernando

    2015-01-01

    The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRONÂ) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long time and there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response.

  3. [Superwarfarine Poisoning].

    PubMed

    Freixo, Ana; Lopes, Luís; Carvalho, Manuela; Araújo, Fernando

    2015-01-01

    The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRONÂ) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long time and there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response. PMID:26421794

  4. Lead poisoning.

    PubMed Central

    Landrigan, P J; Todd, A C

    1994-01-01

    Lead poisoning is the most common disease of environmental origin in the United States today. Adult lead poisoning results primarily from exposure by inhalation in the workplace. Pediatric lead poisoning results principally from the ingestion of lead from environmental media, including paint chips, dust, soil, drinking water, ceramics, and medications. Lead is toxic to many organ systems, among them developing erythrocytes, the kidneys, and the nervous system. Lead-induced toxicity to the central nervous system causes delayed development, diminished intelligence, and altered behavior. In young children, this effect has been demonstrated convincingly to occur at blood lead levels between 10 and 20 micrograms per dl. The Centers for Disease Control and Prevention has recommended that a blood lead level of 10 micrograms per dl or higher be considered evidence of increased lead absorption, and the National Academy of Sciences has concurred in that recommendation. Unresolved issues in need of further study include the frequency of screening young children for lead, the question of whether women should be offered screening for lead before conceiving a pregnancy, the role of x-ray fluorescence analysis in assessing lead in bone, and the appropriate legislative response of the United States government to lead-based paint abatement. PMID:7941534

  5. [Drug poisoning].

    PubMed

    Gainza, I; Nogué, S; Martínez Velasco, C; Hoffman, R S; Burillo-Putze, G; Dueñas, A; Gómez, J; Pinillos, M A

    2003-01-01

    A review is made of acute poisoning by opiates and its treatment in the emergency services, bearing in mind the progressive decline in the number of cases presented with the arrival of new forms of their administration, as well as the presence of new addictive drugs that have resulted in a shift in consumption habits. Reference is also made to the way in which the different types of existing substances originated, with the aim of achieving a better understanding of their use and in order to administer the most suitable treatment when poisoning occurs. Cocaine poisoning is discussed, with reference to its clinical picture, diagnosis and treatment. The consumption of illegal drugs in our country has undergone a notable change in recent years, with heroin being relegated and the incorporation of cocaine, amphetamine derivatives such as "ecstasy" (MDMA), "liquid ecstasy" (GHB) and, to a lesser extent, ketamine. A review is made of cannabis and its derivates, from the history of its consumption and the preparations employed to the effects produced in the different bodily systems. A brief explanation is also given of its metabolites and its principal mechanisms of action. Finally, we comment on the effects of LSD and hallucinogenic mushrooms.

  6. Clinitest tablets poisoning

    MedlinePlus

    Urine sugar reagent poisoning; Anhydrous Benedict's reagent poisoning ... Symptoms of poisoning from Clinitest tablets are: Blood in urine Burns and burning pain in the mouth and throat Collapse Convulsions ...

  7. Mercuric chloride poisoning

    MedlinePlus

    ... Mercuric chloride is a very poisonous form of mercury. It is a type of mercury salt. There are different types of mercury poisonings . This article discusses poisoning from swallowing mercuric ...

  8. Plastic casting resin poisoning

    MedlinePlus

    Epoxy poisoning; Resin poisoning ... Epoxy and resin can be poisonous if they are swallowed or their fumes are breathed in. ... Plastic casting resins are found in various plastic casting resin products.

  9. [¹¹C]Phosgene: a versatile reagent for radioactive carbonyl insertion into medicinal radiotracers for positron emission tomography.

    PubMed

    Roeda, Dirk; Dollé, Frédéric

    2010-01-01

    [¹¹C]Phosgene has been playing a relatively modest but continuous and manifest role all along the history of radiochemistry for Positron Emission Tomography. It acts as a radiolabelling agent through carbonyl insertion, usually between heteroatoms, and benefits from a high chemical reactivity allowing for short reaction times. The aim of this review is to give an overview of this radiochemistry from its beginning until the present day. After drawing up the inventory of the various ways of its production, the reactions in which it has been employed and the labelled products that have been synthesised with it are catalogued. This comprises the reactions of [¹¹C]phosgene with primary, secondary and tertiary amines to labelled isocyanates and carbamoyl chlorides, which serve as intermediates for symmetrical and unsymmetrical [¹¹C]ureas and [¹¹C]carbamates, reactions with alcohols leading to labelled carbamates and carbonates via [¹¹C]chloroformates, cyclisation reactions to heterocycles and the radiochemistry of the secondary radiolabelling agents [¹¹C]urea and diethyl- or dimethyl [¹¹C]carbonate. Apart from this already vast field of chemical possibilities there should be room for extension of the use of [¹¹C]phosgene to other chemistry, notably that of C-¹¹C bond formation. PMID:20583989

  10. Lead Poisoning Prevention Tips

    MedlinePlus

    ... CDC.gov . Lead Home Calendar of Events National Lead Poisoning Prevention Week Archived Materials CDC's Childhood Lead Poisoning Prevention Program Advisory Committee (ACCLPP) Current Activities Blood ...

  11. Protecting Yourself from Poisonous Plants

    MedlinePlus

    ... NIOSH NIOSH Fast Facts: Protecting Yourself from Poisonous Plants Language: English Español (Spanish) Kreyol Haitien (Hatian Creole) ... outdoors is at risk of exposure to poisonous plants, such as poison ivy, poison oak, and poison ...

  12. Immunological battlefield in gastric cancer and role of immunotherapies

    PubMed Central

    Wang, Minyu; Busuttil, Rita A; Pattison, Sharon; Neeson, Paul J; Boussioutas, Alex

    2016-01-01

    Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient’s immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an “us against them” model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy – the tumour cell. PMID:27605873

  13. Mapping a battlefield simulation onto message-passing parallel architectures

    NASA Technical Reports Server (NTRS)

    Nicol, David M.

    1987-01-01

    Perhaps the most critical problem in distributed simulation is that of mapping: without an effective mapping of workload to processors the speedup potential of parallel processing cannot be realized. Mapping a simulation onto a message-passing architecture is especially difficult when the computational workload dynamically changes as a function of time and space; this is exactly the situation faced by battlefield simulations. This paper studies an approach where the simulated battlefield domain is first partitioned into many regions of equal size; typically there are more regions than processors. The regions are then assigned to processors; a processor is responsible for performing all simulation activity associated with the regions. The assignment algorithm is quite simple and attempts to balance load by exploiting locality of workload intensity. The performance of this technique is studied on a simple battlefield simulation implemented on the Flex/32 multiprocessor. Measurements show that the proposed method achieves reasonable processor efficiencies. Furthermore, the method shows promise for use in dynamic remapping of the simulation.

  14. House of Poison: Poisons in the Home.

    ERIC Educational Resources Information Center

    Keller, Rosanne

    One of a series of instructional materials produced by the Literacy Council of Alaska, this booklet provides information about common household poisons. Using a simplified vocabulary and shorter sentences, it provides statistics concerning accidental poisonings; a list of the places poisons are usually found in the home; steps to make the home…

  15. [Mercury poisoning].

    PubMed

    Bensefa-Colas, L; Andujar, P; Descatha, A

    2011-07-01

    Mercury is a widespread heavy metal with potential severe impacts on human health. Exposure conditions to mercury and profile of toxicity among humans depend on the chemical forms of the mercury: elemental or metallic mercury, inorganic or organic mercury compounds. This article aims to reviewing and synthesizing the main knowledge of the mercury toxicity and its organic compounds that clinicians should know. Acute inhalation of metallic or inorganic mercury vapours mainly induces pulmonary diseases, whereas chronic inhalation rather induces neurological or renal disorders (encephalopathy and interstitial or glomerular nephritis). Methylmercury poisonings from intoxicated food occurred among some populations resulting in neurological disorders and developmental troubles for children exposed in utero. Treatment using chelating agents is recommended in case of symptomatic acute mercury intoxication; sometimes it improves the clinical effects of chronic mercury poisoning. Although it is currently rare to encounter situations of severe intoxication, efforts remain necessary to decrease the mercury concentration in the environment and to reduce risk on human health due to low level exposure (dental amalgam, fish contamination by organic mercury compounds…). In case of occupational exposure to mercury and its compounds, some disorders could be compensated in France. Clinicians should work with toxicologists for the diagnosis and treatment of mercury intoxication.

  16. Phosgene- and chlorine-induced acute lung injury in rats: comparison of cardiopulmonary function and biomarkers in exhaled breath.

    PubMed

    Luo, Sa; Trübel, Hubert; Wang, Chen; Pauluhn, Jürgen

    2014-12-01

    This study compares changes in cardiopulmonary function, selected endpoints in exhaled breath, blood, and bronchoalveolar lavage fluid (BAL) following a single, high-level 30-min nose-only exposure of rats to chlorine and phosgene gas. The time-course of lung injury was systematically examined up to 1-day post-exposure with the objective to identify early diagnostic biomarkers suitable to guide countermeasures to accidental exposures. Chlorine, due to its water solubility, penetrates the lung concentration-dependently whereas the poorly water-soluble phosgene reaches the alveolar region without any appreciable extent of airway injury. Cardiopulmonary endpoints were continually recorded by telemetry and barometric plethysmography for 20h. At several time points blood was collected to evaluate evidence of hemoconcentration, changes in hemostasis, and osteopontin. One day post-exposure, protein, osteopontin, and cytodifferentials were determined in BAL. Nitric oxide (eNO) and eCO2 were non-invasively examined in exhaled breath 5 and 24h post-exposure. Chlorine-exposed rats elaborated a reflexively-induced decreased respiratory rate and bradycardia whereas phosgene-exposed rats developed minimal changes in lung function but a similar magnitude of bradycardia. Despite similar initial changes in cardiac function, the phosgene-exposed rats showed different time-course changes of hemoconcentration and lung weights as compared to chlorine-exposed rats. eNO/eCO2 ratios were most affected in chlorine-exposed rats in the absence of any marked time-related changes. This outcome appears to demonstrate that nociceptive reflexes with changes in cardiopulmonary function resemble typical patterns of mixed airway-alveolar irritation in chlorine-exposed rats and alveolar irritation in phosgene-exposed rats. The degree and time-course of pulmonary injury was reflected best by eNO/eCO2 ratios, hemoconcentration, and protein in BAL. Increased fibrin in blood occurred only in chlorine

  17. Phosgene- and chlorine-induced acute lung injury in rats: comparison of cardiopulmonary function and biomarkers in exhaled breath.

    PubMed

    Luo, Sa; Trübel, Hubert; Wang, Chen; Pauluhn, Jürgen

    2014-12-01

    This study compares changes in cardiopulmonary function, selected endpoints in exhaled breath, blood, and bronchoalveolar lavage fluid (BAL) following a single, high-level 30-min nose-only exposure of rats to chlorine and phosgene gas. The time-course of lung injury was systematically examined up to 1-day post-exposure with the objective to identify early diagnostic biomarkers suitable to guide countermeasures to accidental exposures. Chlorine, due to its water solubility, penetrates the lung concentration-dependently whereas the poorly water-soluble phosgene reaches the alveolar region without any appreciable extent of airway injury. Cardiopulmonary endpoints were continually recorded by telemetry and barometric plethysmography for 20h. At several time points blood was collected to evaluate evidence of hemoconcentration, changes in hemostasis, and osteopontin. One day post-exposure, protein, osteopontin, and cytodifferentials were determined in BAL. Nitric oxide (eNO) and eCO2 were non-invasively examined in exhaled breath 5 and 24h post-exposure. Chlorine-exposed rats elaborated a reflexively-induced decreased respiratory rate and bradycardia whereas phosgene-exposed rats developed minimal changes in lung function but a similar magnitude of bradycardia. Despite similar initial changes in cardiac function, the phosgene-exposed rats showed different time-course changes of hemoconcentration and lung weights as compared to chlorine-exposed rats. eNO/eCO2 ratios were most affected in chlorine-exposed rats in the absence of any marked time-related changes. This outcome appears to demonstrate that nociceptive reflexes with changes in cardiopulmonary function resemble typical patterns of mixed airway-alveolar irritation in chlorine-exposed rats and alveolar irritation in phosgene-exposed rats. The degree and time-course of pulmonary injury was reflected best by eNO/eCO2 ratios, hemoconcentration, and protein in BAL. Increased fibrin in blood occurred only in chlorine

  18. Prevention of Food Poisoning.

    ERIC Educational Resources Information Center

    Army Quartermaster School, Ft. Lee, VA.

    The programed text provides a single lesson, four-hour, correspondence subcourse on the prevention of food poisoning. It covers the following areas: a definition of food poisoning; chemical food poisoning; biological food poisoning; causes and prevention of trichinosis; six factors controlling bacteria growth; bacterial infection; prevention of…

  19. Poisons information in Singapore.

    PubMed

    Chao, T C; Tay, M K; Bloodworth, B C; Lim, K H

    1993-03-01

    The Poisons Information Centre (PIC) provides viral and timely information to prevent and manage poisoning episodes. Comprehensive information on household, agricultural and industrial chemicals, natural toxins, pharmaceuticals, local antidote stocks and local poisons experts is retrieved from the Centre's computerised information system and printed literature. Public subscribers can obtain poisons information through Teleview.

  20. Photocatalysis of gaseous trichloroethylene (TCE) over TiO2: the effect of oxygen and relative humidity on the generation of dichloroacetyl chloride (DCAC) and phosgene.

    PubMed

    Ou, Hsin-Hung; Lo, Shang-Lien

    2007-07-19

    Batch photocatalytic degradation of 80+/-2.5 ppm V trichloroethylene (TCE) was conducted to investigate the effect of the oxygen and relative humidity (RH) on the formation of the dichloroacetyl chloride (DCAC) and phosgene. Based on the simultaneous ordinary differential equations (ODEs), the reaction rate constants of TCE ((2.31+/-0.28) approximately (9.41+/-0.63)x10(-2) min(-1)) are generally larger than that of DCAC ((0.94+/-1.25) approximately (9.35+/-1.71)x10(-3) min(-1)) by approximate one order. The phenomenon indicates the degradation potential of TCE is superior to that of DCAC. DCAC appreciably delivers the same degradation behavior with TCE that means there exists an optimum RH and oxygen concentration for photocatalysis of TCE and DCAC. At the time the peak yield of DCAC appears, the conversion ratio based on the carbon atom from TCE to DCAC is within the range of 30-83% suggesting that the DCAC generation is significantly attributed to TCE degradation. Regarding the phosgene formation, the increasing oxygen amount leads to the inhibitory effect on the phosgene yield which fall within the range of 5-15%. The formation mechanism of phosgene was also inferred that the Cl atoms attacking the C-C bond of DCAC results to the generation of phosgene rather than directly from the TCE destruction.

  1. Neurotoxic marine poisoning.

    PubMed

    Isbister, Geoffrey K; Kiernan, Matthew C

    2005-04-01

    Marine poisoning results from the ingestion of marine animals that contain toxic substances and causes substantial illness in coastal regions. Three main clinical syndromes of marine poisoning have important neurological symptoms-ciguatera, tetrodotoxin poisoning, and paralytic shellfish poisoning. Ciguatera is the commonest syndrome of marine poisoning and is characterised by moderate to severe gastrointestinal effects (vomiting, diarrhoea, and abdominal cramps) and neurological effects (myalgia, paraesthesia, cold allodynia, and ataxia), but is rarely lethal. Tetrodotoxin poisoning and paralytic shellfish poisoning are less common but have a higher fatality rate than ciguatera. Mild gastrointestinal effects and a descending paralysis are characteristic of these types of poisoning. In severe poisoning, paralysis rapidly progresses to respiratory failure. Diagnosis of all types of marine poisoning is made from the circumstances of ingestion (type of fish and location) and the clinical effects. Because there are no antidotes, supportive care, including mechanical ventilation in patients with severe paralysis, is the mainstay of treatment.

  2. 75 FR 69125 - River Raisin National Battlefield Park, MI ; Account Number: 6495

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... National Park Service River Raisin National Battlefield Park, MI ; Account Number: 6495 AGENCY: National Park Service, Department of the Interior. ACTION: Notification of a New National Park, River Raisin National Battlefield Park. SUMMARY: As authorized by Section 7003 of the Omnibus Public Land Management...

  3. Ulinastatin reduces pathogenesis of phosgene-induced acute lung injury in rats.

    PubMed

    Shen, Jie; Gan, Zhengyi; Zhao, Jie; Zhang, Liming; Xu, Guoxiong

    2014-10-01

    Phosgene (CG) is an industrial chemical used to make plastics, rubbers, dyestuff, and pesticides. Although the inhalation of CG is relatively uncommon, its accidental exposure can lead to acute lung injury (ALI). Ulinastatin, a urinary trypsin inhibitor, has been emerged to use for the treatment of acute inflammatory state of a number of organs including the lung. In this study, we examined the pathogenic changes in the lungs after the inhalation of CG gas and also examined the effect of ulinastatin treatment in reversing these changes in rats. We found that the rats exposed to CG gas at a dose of 5.0 g/m(3) for 5 min led to ALI after 6 h. The signs of lung injury include pulmonary edema, hemorrhage, and cellular infiltration in pulmonary alveoli. In addition, interleukin-15 (IL-15) and intercellular adhesion molecule-1 (ICAM-1) were significantly increased in CG-inhaled animals. Ulinastatin administration at 1 h postexposure significantly reduced the intensity of all the pathological changes in the lungs of these CG-exposed animals. Ulinastatin at a dose of 400 U/g was shown to decrease the total number of cells in bronchoalveolar lavage fluid and the levels of IL-15 and ICAM-1 in the serum. We also found that the structure of the lung was protected by ulinastatin treatment. Thus, our data suggest that ulinastatin can be used as an effective drug for the treatment of CG-induced ALI. The serum levels of IL-15 and ICAM-1 can be used as the markers of lung injury after exposure to CG and may also serve as useful therapeutic targets at an early stage. The effects of long-term treatment of ulinastatin and the mechanisms by which ulinastatin decreases the infiltration of blood cells and reduces cytokines need further investigation.

  4. Ground-target detection in a virtual battlefield

    NASA Astrophysics Data System (ADS)

    Gozard, Patrick; Cathala, Thierry

    2007-04-01

    To perform multi-sensors simulations, the French DGA/DET (Directorate for Technical Evaluation of the French Ministry of Defense) uses CHORALE (simulated Optronic Acoustic Radar battlefield). CHORALE enables the user to create virtual and realistic multi spectral 3D scenes, and generates the physical signal received by one or several sensors, typically an IR sensor or an acoustic sensor. This article presents how the expertise is made to evaluate smart ammunition to detect ground target with infrared sensor and shape detector in a virtual battlefield with the environment CHORALE and the workshop AMOCO. The scene includes background with trees, houses, roads, fields, targets, and the ammunition. Each tool is explained to understand the physics phenomena in the scene to take into account atmospheric transmission, radiative parameters of objects and counter-measure devices. Then numeric models are described as the 6 DOF ballistics models, sensor model according precise positions inside the ammunition as well as the different steps of calculation between industrial model and technical model to obtain the global simulation. Finally, this paper explains some results of the evaluation compared with the true behavior after tests on proving ground. Then future evolutions are presented to perform similar evaluation with other kind of intelligent ammunition in a real-time model.

  5. Arsenic: the forgotten poison?

    PubMed

    Barton, E N; Gilbert, D T; Raju, K; Morgan, O S

    1992-03-01

    Chronic arsenic poisoning is an uncommon cause of peripheral neuropathy in Jamaica. A patient with this disorder is described. The insidious nature of chronic arsenic poisoning, with its disabling complications, is emphasised.

  6. Household glue poisoning

    MedlinePlus

    ... SW, Burns MJ, eds. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose . 4th ed. Philadelphia, PA: Elsevier Saunders; 2007:chap 94. Zosel AE. General approach to the poisoned patient. In: Adams JG, ...

  7. Hand lotion poisoning

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/002708.htm Hand lotion poisoning To use the sharing features on this page, please enable JavaScript. Hand lotion poisoning occurs when someone swallows hand lotion or ...

  8. Bubble bath soap poisoning

    MedlinePlus

    ... medlineplus.gov/ency/article/002762.htm Bubble bath soap poisoning To use the sharing features on this page, please enable JavaScript. Bubble bath soap poisoning occurs when someone swallows bubble bath soap. ...

  9. Furniture polish poisoning

    MedlinePlus

    ... eyes, or ears Severe stomach pain Throat swelling Vomiting, possibly bloody Blood in your stools If the poison touched your skin or eyes you may have: Skin burns and irritation Vision loss If the poison is ...

  10. Potassium hydroxide poisoning

    MedlinePlus

    This article discusses poisoning from swallowing or touching potassium hydroxide or products that contain this chemical. This article is for information only. Do NOT use it to treat or manage an actual poison exposure. If ...

  11. Toluene and xylene poisoning

    MedlinePlus

    Xylene poisoning ... Below are symptoms of toluene and xylene poisoning in different parts of the body. EYES, EARS, NOSE, AND THROAT Blurred vision Burning pain Hearing loss STOMACH AND INTESTINES Bloody stools Abdominal ...

  12. Carbon Monoxide Poisoning

    MedlinePlus

    ... them in. The most common symptoms of CO poisoning are Headache Dizziness Weakness Nausea Vomiting Chest pain ... often hard to tell if someone has CO poisoning, because the symptoms may be like those of ...

  13. Cold wave lotion poisoning

    MedlinePlus

    Thioglycolate poisoning ... Below are symptoms of cold wave lotion poisoning in different parts of the body. EYES, EARS, NOSE, AND THROAT Mouth irritation Burning and redness of the eyes Possibly serious damage to ...

  14. Boric acid poisoning

    MedlinePlus

    Borax poisoning ... The main symptoms of boric acid poisoning are blue-green vomit, diarrhea, and a bright red rash on the skin. Other symptoms may include: Blisters Collapse Coma Convulsions Drowsiness ...

  15. Hair bleach poisoning

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002702.htm Hair bleach poisoning To use the sharing features on this page, please enable JavaScript. Hair bleach poisoning occurs when someone swallows hair bleach or ...

  16. Plant fertilizer poisoning

    MedlinePlus

    Plant fertilizers and household plant foods are used to improve plant growth. Poisoning can occur if someone swallows these products. Plant fertilizers are mildly poisonous if small amounts are swallowed. ...

  17. Bracken fern poisoning

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bracken fern (Pteridium aquilinum) is found throughout the world and enzootic hematuria, bright blindness, and bracken staggers. This chapter reviews the plant, the various poisoning syndrome that it produces, the current strategies to prevent poisoning, and recommended treatments....

  18. Ciguatera Fish Poisoning

    MedlinePlus

    ... By Syndrome Life Cycle Impacts Human Health Wildlife Ecosystems Socioeconomic Freshwater Regions Distribution - U.S. Distribution - World Maps ... Paralytic Shellfish Poisoning Cyanobacteria Medical Community ... Fish Poisoning Causative organisms: Gambierdiscus ...

  19. Hydrochloric acid poisoning

    MedlinePlus

    Hydrochloric acid is a clear, poisonous liquid. It is highly corrosive, which means it immediately causes severe ... discusses poisoning due to swallowing or breathing in hydrochloric acid. This article is for information only. Do ...

  20. [Natural toxin poisoning].

    PubMed

    Tsunematsu, Satoshi

    2012-08-01

    Natural toxin poisoning often occurs when amateur who has no expert knowledge of food collects and cooks the wrong material. In many cases, the symptoms of natural toxin poisoning are mild and the patients recover from illness within a day. However, if the patients have respiratory or neurological symptoms after several hours of intake, the patients must go to hospital immediately. Mushroom poisoning is often reported and puffer fish poisoning is sometimes reported in Japan.

  1. Lead Poisoning (For Parents)

    MedlinePlus

    ... Story" 5 Things to Know About Zika & Pregnancy Lead Poisoning KidsHealth > For Parents > Lead Poisoning Print A A ... Family en español La intoxicación por plomo About Lead Poisoning If you have young kids, it's important to ...

  2. Lead Poisoning in Childhood.

    ERIC Educational Resources Information Center

    Pueschel, Siegfried M., Ed.; Linakis, James G., Ed.; Anderson, Angela C., Ed.

    The magnitude of childhood lead poisoning has been inexplicably neglected by modern medicine and by legislators. However, since the 1970s, increased attention has been focused on lead poisoning, and advances have been made in several areas, including understanding of the neurodevelopmental and behavioral ramifications of lead poisoning, and…

  3. Lead Poisoning in Children.

    ERIC Educational Resources Information Center

    Drummond, A. H., Jr.

    1981-01-01

    Early symptoms of lead poisoning in children are often overlooked. Lead poisoning has its greatest effects on the brain and nervous system. The obvious long-term solution to the lead poisoning problem is removal of harmful forms of the metal from the environment. (JN)

  4. Lead poisoning: An overview

    NASA Technical Reports Server (NTRS)

    Gendel, Neil

    1993-01-01

    A problem that should be of great concern to all of us is the lead poisoning of children. First, I would like to present a short overview concerning the reasons everyone should care about lead poisoning, then discuss the history of lead poisoning, what is happening today across the country, and the future.

  5. Effects of depletion of ascorbic acid or nonprotein sulfhydryls on the acute inhalation toxicity of nitrogen dioxide, ozone, and phosgene

    SciTech Connect

    Slade, R.; Highfill, J.W.; Hatch, G.E.

    1989-01-01

    The effect of depleting lung ascorbic acid (AH{sub 2}) and nonprotein sulfhydryls (NPSH) on the acute inhalation toxicity of nitrogen dioxide (NO{sub 2}), ozone (O{sub 3}), and phosgene (COCl{sub 2}) was investigated in guinea pigs. The increase in bronchoalveolar lavage (BAL) fluid protein (an indicator of alveolar-capillary damage leading to increased permeability) was measured 16 to 18 hr following a 4 hr exposure to the gas in animals deficient in (AH{sub 2}) or NPSH. Gas concentrations were chosen which produced low but significant increases in BAL protein. Lung (AH{sub 2}) was lowered to about 20% of control by feeding rabbit chow for 2 weeks. Lung NPSH was lowered to about 50% of control by injecting a mixture of buthionine S,R-sulfoximine (BSO) and diethylmaleate (DEM) (2.7 and 1.2 mmol/kg respectively). BSO/DEM did not affect the lung concentrations of (AH{sub 2}) or alpha-tocopherol. AH{sub 2} depletion caused a 6 fold and a 3 fold enhancement in the toxicity of 5 ppm and 10 ppm (NO{sub 2}), and a 6 fold enhancement in the toxicity of 0.5 ppm (O{sub 3}), but did not affect toxicity of 1.0 ppm (O{sub 3}). AH{sub 2} depletion did not affect phosgene toxicity (at 0.25 ppm and 0.5 ppm).

  6. Poison centers, poison prevention, and the pediatrician.

    PubMed

    Lovejoy, F H; Robertson, W O; Woolf, A D

    1994-08-01

    The first poison centers were established in the United States in the early 1950s, stimulated by an American Academy of Pediatrics' survey of office-based pediatric practices which ascertained that its members had no place to turn for ingredient information on medications and household products. With the help of the Academy, pediatrician Dr. Edward Press, the Illinois Department of Health, and several community hospitals, the first poison center emerged. Over the subsequent 40 years, remarkable progress has occurred in the fields of clinical toxicology, poison control, and poison prevention. Yet despite these accomplishments, challenging clouds are appearing on the horizon which threaten these gains. This commentary, by the authors who have viewed and participated in a large part of the history of this progress, will focus on these major accomplishments with an emphasis on (a) poison prevention utilizing the pre-event (primary prevention), (b) the event (secondary prevention), and (c) the postevent (tertiary prevention) model.

  7. Poisoning: Effective Clinical Intervention

    PubMed Central

    Turner, T. J.

    1982-01-01

    Poisoning accounts for 40-60% of suicides, is the commonest medical emergency in small children, and an important source of occupational injury. Prevention of unintentional poisoning involves primarily education of parents. In intervention, the patient—not the poison—must be treated. Self-poisoners require supportive but firm handling. Treatment is directed towards prevention of further absorption, removal of absorbed poison, symptomatic or supportive therapy, and administration of systemic antidotes. Careful attention should be paid to the physician's legal responsibilities in cases of poisoning. Imagesp2032-a PMID:21286544

  8. Military applications of the laser weapons in the future battlefield

    NASA Astrophysics Data System (ADS)

    Celik, Hasan; Adana, Saban; Yahsi, Erhan

    2013-05-01

    Contemporary operating environment requires a wide range of tools to respond to a myriad of regular and irregular threats. Accordingly, conventional weapons do not suffice in some cases. As technology improves exponentially, the dominance of conventional weapons is slowly fading away by the advances in laser technology. This study first outlines the characteristics of laser weapons, then provides the military applications of them in land, maritime, air and space domains and finally exhibits implications for battlefield functions. This study concludes that any country that is seeking primacy in military terms must allocate extra time and resources to obtain this emerging technology. Since it seems that there are not adequate studies about the military applications and operational concepts of the laser weapons, this study tries to increase awareness about their potential advantages.

  9. Improvements of cyberspace and effects to the battlefield

    NASA Astrophysics Data System (ADS)

    Gedıklı, Münir

    2014-06-01

    Wars previously being executed at land and sea have also become applicable in air and space due to the advancements of aircraft and satellite systems. Rapid improvements in information technologies have triggered the concept of cyberspace which is considered as the fifth dimension of war. While transferring information quickly from physical area to electronic/digital area, cyberspace has caused to emerge a lot of threats and methods like cyber-attack, cyber-crime, cyber war which are spreading too rapidly. Individuals, institutions and establishments have begun to take their own cyber security precautions to cope with these threats. This study gives information about the concepts and advances on cyberspace in order to raise comprehensive awareness. The study also focuses on the effects of these improvements in the battlefield, and analyzes them.

  10. Attempts to counteract phosgene-induced acute lung injury by instant high-dose aerosol exposure to hexamethylenetetramine, cysteine or glutathione.

    PubMed

    Pauluhn, Jürgen; Hai, Chun Xue

    2011-01-01

    Phosgene is an important high-production-volume intermediate with widespread industrial use. Consistent with other lung irritants causing ALI (acute lung injury), mode-of-action-based countermeasures remain rudimentary. This study was conducted to analyze whether extremely short high-level exposure to phosgene gas could be mitigated using three different inhaled nucleophiles administered by inhalation instantly after exposure to phosgene. Groups of young adult male Wistar rats were acutely exposed to carbonyl chloride (phosgene) using a directed-flow nose-only mode of exposure of 600 mg/m³ for 1.5 min (225 ppm × min). Immediately after exposure to phosgene gas the rats were similarly exposed to three strong nucleophiles with and without antioxidant properties for 5 or 15 min. The following nucleophiles were used: hexamethylenetetramine (HMT), l-cysteine (Cys), and l-glutathione (GSH). The concentration of the aerosol (mass median aerodynamic diameter 1.7-2 µm) was targeted to be in the range of 1 mg/L. Cys and GSH have antioxidant properties in addition. The calculated alveolar molar dosage of phosgene was 9 µmol/kg. At 15-min exposure duration, the respective inhaled dose of HMT, Csy, and GSH were 111, 103, and 46 µmol/kg, respectively. The alveolar dose of drugs was ~10-times lower. The efficacy of treatment was judged by protein concentrations in bronchoalveolar lavage fluid (BALF) collected 1 day post-exposure. In spite of using optimized aerosolization techniques, none of the nucleophiles chosen had any mitigating effect on BALF-protein extravasation. This finding appear to suggest that inhaled phosgene gas acylates instantly nucleophilic moieties at the site of initial deposition and that the resultant reaction products can not be reactivated even following instant inhalation treatment with competing nucleophilic agents. In spite of using maximal technically attainable concentrations, it appears to be experimentally challenging to deliver

  11. The fate of atmospheric phosgene and the stratospheric chlorine loadings of its parent compounds: CCl4, C2Cl4, C2HCL3, CH3CCl3, and CHCl3

    NASA Technical Reports Server (NTRS)

    Kindler, T. P.; Chameides, W. L.; Wine, P. H.; Cunnold, D. M.; Alyea, F. N.; Franklin, J. A.

    1995-01-01

    A study of the tropospheric and stratospheric cycles of phosgene is carried out to determine its fate and ultimate role in controlling the ozone depletion potentials of its parent compounds. Tropospheric phosgene is produced from the OH-initiated oxidation of C2Cl4, CH3CCl3, CHCl3, and C2HCl3. Simulations using a two-dimensional model indicate that these processes produce about 90 pptv/yr of tropospheric phosgene with an average concentration of about 18 pptv, in reasonable agreement with observations. We estimate a residence time of about 70 days for tropospheric phosgene, with the vast majority being removed by hydrolysis in cloudwater. Only about 0.4% of the phosgene produced in the troposphere avoids wet removal and is transported to the stratosphere, where its chlorine can be released to participate in the catalytic destruction of ozone. Stratospheric phosgene is produced from the photochemical degradation of CCl4, C2Cl4, CHCl3, and CH3CCl3 and is removed by photolysis and downward transport to the troposphere. Model calculations, in good agreement with observations, indicate that these processes produce a peak stratospheric concentration of about 25-30 pptv at an altitude of about 25 km. In contrast to tropospheric phosgene, stratospheric phosgene is found to have a lifetime against photochemical removal of the order of years. As a result, a significant portion of the phosgene that is produced in the stratosphere is ultimately returned to the troposphere, where it is rapidly removed by clouds. This phenomenon effectively decreases the amount of reactive chlorine injected into the stratosphere and available for ozone depletion from phosgene's parent compounds. A similar phenomenon due to the downward transport of stratospheric COFCl produced from CFC-11 is estimated to cause a 7% decrease in the amount of reactive chlorine injected into the stratosphere from this compound. Our results are potentially sensitive to a variety of parameters, most notably the rate

  12. Glyphosate poisoning.

    PubMed

    Bradberry, Sally M; Proudfoot, Alex T; Vale, J Allister

    2004-01-01

    Glyphosate is used extensively as a non-selective herbicide by both professional applicators and consumers and its use is likely to increase further as it is one of the first herbicides against which crops have been genetically modified to increase their tolerance. Commercial glyphosate-based formulations most commonly range from concentrates containing 41% or more glyphosate to 1% glyphosate formulations marketed for domestic use. They generally consist of an aqueous mixture of the isopropylamine (IPA) salt of glyphosate, a surfactant, and various minor components including anti-foaming and colour agents, biocides and inorganic ions to produce pH adjustment. The mechanisms of toxicity of glyphosate formulations are complicated. Not only is glyphosate used as five different salts but commercial formulations of it contain surfactants, which vary in nature and concentration. As a result, human poisoning with this herbicide is not with the active ingredient alone but with complex and variable mixtures. Therefore, It is difficult to separate the toxicity of glyphosate from that of the formulation as a whole or to determine the contribution of surfactants to overall toxicity. Experimental studies suggest that the toxicity of the surfactant, polyoxyethyleneamine (POEA), is greater than the toxicity of glyphosate alone and commercial formulations alone. There is insufficient evidence to conclude that glyphosate preparations containing POEA are more toxic than those containing alternative surfactants. Although surfactants probably contribute to the acute toxicity of glyphosate formulations, the weight of evidence is against surfactants potentiating the toxicity of glyphosate. Accidental ingestion of glyphosate formulations is generally associated with only mild, transient, gastrointestinal features. Most reported cases have followed the deliberate ingestion of the concentrated formulation of Roundup (The use of trade names is for product identification purposes only and

  13. Marijuana poisoning.

    PubMed

    Fitzgerald, Kevin T; Bronstein, Alvin C; Newquist, Kristin L

    2013-02-01

    , tremors, hypothermia, and bradycardia. Higher dosages may additionally cause nystagmus, agitation, tachypnea, tachycardia, ataxia, hyperexcitability, and seizures. Treatment of marijuana ingestion in animals is largely supportive. Vital signs including temperature and heart rate and rhythm must be continually monitored. Stomach content and urine can be tested for cannabinoids. Gas chromatography and mass spectrometry can be utilized for THC detection but usually may take several days and are not practical for initiation of therapy. Human urine drug-screening tests can be unreliable for confirmation of marijuana toxicosis in dogs owing to the interference of a large number of the metabolites in canine urine. False negatives may also arise if testing occurs too recently following THC ingestion. Thus, the use of human urine drug-screening tests in dogs remains controversial. No specific antidote presently exists for THC poisoning. Sedation with benzodiazepines may be necessary if dogs are severely agitated. Intravenous fluids may be employed to counter prolonged vomiting and to help control body temperature. Recently, the use of intralipid therapy to bind the highly lipophilic THC has been utilized to help reduce clinical signs. The majority of dogs experiencing intoxication after marijuana ingestion recover completely without sequellae. Differential diagnoses of canine THC toxicosis include human pharmaceuticals with central nervous system stimulatory effects, drugs with central nervous system depressant effects, macrolide parasiticides, xylitol, and hallucinogenic mushrooms.

  14. Marijuana poisoning.

    PubMed

    Fitzgerald, Kevin T; Bronstein, Alvin C; Newquist, Kristin L

    2013-02-01

    , tremors, hypothermia, and bradycardia. Higher dosages may additionally cause nystagmus, agitation, tachypnea, tachycardia, ataxia, hyperexcitability, and seizures. Treatment of marijuana ingestion in animals is largely supportive. Vital signs including temperature and heart rate and rhythm must be continually monitored. Stomach content and urine can be tested for cannabinoids. Gas chromatography and mass spectrometry can be utilized for THC detection but usually may take several days and are not practical for initiation of therapy. Human urine drug-screening tests can be unreliable for confirmation of marijuana toxicosis in dogs owing to the interference of a large number of the metabolites in canine urine. False negatives may also arise if testing occurs too recently following THC ingestion. Thus, the use of human urine drug-screening tests in dogs remains controversial. No specific antidote presently exists for THC poisoning. Sedation with benzodiazepines may be necessary if dogs are severely agitated. Intravenous fluids may be employed to counter prolonged vomiting and to help control body temperature. Recently, the use of intralipid therapy to bind the highly lipophilic THC has been utilized to help reduce clinical signs. The majority of dogs experiencing intoxication after marijuana ingestion recover completely without sequellae. Differential diagnoses of canine THC toxicosis include human pharmaceuticals with central nervous system stimulatory effects, drugs with central nervous system depressant effects, macrolide parasiticides, xylitol, and hallucinogenic mushrooms. PMID:23796481

  15. Scombroid poisoning: a review.

    PubMed

    Hungerford, James M

    2010-08-15

    Scombroid poisoning, also called histamine fish poisoning, is an allergy-like form of food poisoning that continues to be a major problem in seafood safety. The exact role of histamine in scombroid poisoning is not straightforward. Deviations from the expected dose-response have led to the advancement of various possible mechanisms of toxicity, none of them proven. Histamine action levels are used in regulation until more is known about the mechanism of scombroid poisoning. Scombroid poisoning and histamine are correlated but complicated. Victims of scombroid poisoning respond well to antihistamines, and chemical analyses of fish implicated in scombroid poisoning generally reveal elevated levels of histamine. Scombroid poisoning is unique among the seafood toxins since it results from product mishandling rather than contamination from other trophic levels. Inadequate cooling following harvest promotes bacterial histamine production, and can result in outbreaks of scombroid poisoning. Fish with high levels of free histidine, the enzyme substrate converted to histamine by bacterial histidine decarboxylase, are those most often implicated in scombroid poisoning. Laboratory methods and screening methods for detecting histamine are available in abundance, but need to be compared and validated to harmonize testing. Successful field testing, including dockside or on-board testing needed to augment HACCP efforts will have to integrate rapid and simplified detection methods with simplified and rapid sampling and extraction. Otherwise, time-consuming sample preparation reduces the impact of gains in detection speed on the overall analysis time.

  16. [Acute salicylate poisoning].

    PubMed

    Reingardiene, Dagmara; Lazauskas, Robertas

    2006-01-01

    Although aspirin (acetylsalicylic acid) has become widely available without prescription, cases of self-poisoning due to overdose of salicylates are quite uncommon, with a low reported mortality. However, severe poisoning with these preparations is life threatening. Besides the aspirin, there are other sources of salicylate poisoning, such as an excessive application of topical agents, ingestion of salicylate containing ointments, use of keratolytic agents or agents containing methyl salicylate (e.g. oil of wintergreen). Most of these preparations are liquid, highly concentrated and lipid soluble, and, therefore, they are able to provoke a severe, rapid salicylate poisoning. On the basis of clinical and metabolic features or salicylate concentration in plasma it is very important to diagnose severe poisoning with salicylates in time and prescribe an adequate treatment. In the present review article various aspects of salicylate poisoning and its treatment are discussed: epidemiology, pharmacokinetics and pharmacodynamics of salicylates, clinical manifestations of their toxicity, management, enhanced elimination and prognosis.

  17. Phosphorus poisoning in waterfowl

    USGS Publications Warehouse

    Coburn, D.R.; DeWitt, J.B.; Derby, J.V.; Ediger, E.

    1950-01-01

    Black ducks and mallards were found to be highly susceptible to phosphorus poisoning. 3 mg. of white phosphorus per kg. of body weight given in a single dose resulted in death of a black duck in 6 hours. Pathologic changes in both acute and chronic poisoning were studied. Data are presented showing that diagnosis can be made accurately by chemical analysis of stored tissues in cases of phosphorus poisoning.

  18. Grass and weed killer poisoning

    MedlinePlus

    Weedoff poisoning; Roundup poisoning ... Glyphosate is the poisonous ingredient in some weed killers. ... Glyphosate is in weed killers with these brand names: Roundup Bronco Glifonox Kleen-up Rodeo Weedoff Other ...

  19. Poison Ivy, Oak, and Sumac

    MedlinePlus

    ... U.S.) is a delayed allergic reaction. Brushing the plant on the skin results in blisters and slightly ... of poison ivy, poison oak, and poison sumac plants. People typically have itchy bumps (papules) and blisters ( ...

  20. Research and development of a field-ready protocol for sampling of phosgene from stationary source emissions: Diethylamine reagent studies. Research report, 11 July 1995--30 September 1996

    SciTech Connect

    Steger, J.L.; Bursey, J.T.; Merrill, R.G.; Epperson, D.

    1999-03-01

    This report presents the results of laboratory studies to develop and evaluate a method for the sampling and analysis of phosgene from stationary sources of air emissions using diethylamine (DEA) in toluene as the collection media. The method extracts stack gas from emission sources and stabilizes the reactive gas for subsequent analysis. DEA was evaluated both in a benchtop study and in a laboratory train spiking study. This report includes results for both the benchtop study and the train spiking study. Benchtop studies to evaluate the suitability of DEA for collecting and analyzing phosgene investigated five variables: storage time, DEA concentration, moisture/pH, phosgene concentration, and sample storage temperature. Prototype sampling train studies were performed to determine if the benchtop chemical studies were transferable to a Modified Method 5 sampling train collecting phosgene in the presence of clean air mixed with typical stack gas components. Four conditions, which varied the moisture and phosgene spike were evaluated in triplicate. In addition to research results, the report includes a detailed draft method for sampling and analysis of phosgene from stationary source emissions.

  1. Of Penguins, Pinnipeds, and Poisons: Anesthesia on Elephant Island.

    PubMed

    Firth, Paul G

    2016-07-01

    Although Ernest Shackleton's Endurance Antarctic expedition of 1914 to 1916 is a famous epic of survival, the medical achievements of the two expedition doctors have received little formal examination. Marooned on Elephant Island after the expedition ship sank, Drs. Macklin and McIlroy administered a chloroform anesthetic to crew member Perce Blackborow to amputate his frostbitten toes. As the saturated vapor pressure of chloroform at 0°C is 71.5 mmHg and the minimum alveolar concentration is 0.5% of sea-level atmospheric pressure (3.8 mmHg), it would have been feasible to induce anesthesia at a low temperature. However, given the potentially lethal hazards of a light chloroform anesthetic, an adequate and constant depth of anesthesia was essential. The pharmacokinetics of the volatile anesthetic, administered via the open-drop technique in the frigid environment, would have been unfamiliar to the occasional anesthetist. To facilitate vaporization of the chloroform, the team burned penguin skins and seal blubber under overturned lifeboats to increase the ambient temperature from -0.5° to 26.6°C. Chloroform degrades with heat to chlorine and phosgene, but buildup of these poisonous gases did not occur due to venting of the confined space by the stove chimney. The anesthetic went well, and the patient-and all the ship's crew-survived to return home. PMID:27148920

  2. Revolutionary optical sensor for physiological monitoring in the battlefield

    NASA Astrophysics Data System (ADS)

    Kingsley, Stuart A.; Sriram, Sriram; Pollick, Andrea; Marsh, John

    2004-09-01

    SRICO has developed a revolutionary approach to physiological status monitoring using state-of-the-art optical chip technology. The company"s patent pending Photrode is a photonic electrode that uses unique optical voltage sensing technology to measure and monitor electrophysiological parameters. The optical-based monitoring system enables dry-contact measurements of EEG and ECG signals that require no surface preparation or conductive gel and non-contact measurements of ECG signals through the clothing. The Photrode applies high performance optical integrated circuit technology, that has been successfully implemented in military & commercial aerospace, missile, and communications applications for sensing and signal transmission. SRICO"s award winning Photrode represents a new paradigm for the measurement of biopotentials in a reliable, convenient, and non-intrusive manner. Photrode technology has significant applications on the battlefield for rapid triage to determine the brain dead from those with viable brain function. An ECG may be obtained over the clothing without any direct skin contact. Such applications would enable the combat medic to receive timely medical information and to make important decisions regarding identification, location, triage priority and treatment of casualties. Other applications for the Photrode include anesthesia awareness monitoring, sleep medicine, mobile medical monitoring for space flight, emergency patient care, functional magnetic resonance imaging, various biopotential signal acquisition (EMG, EOG), and routine neuro and cardio diagnostics.

  3. Software for multimodal battlefield signal modeling and optimal sensor placement

    NASA Astrophysics Data System (ADS)

    Yamamoto, Kenneth K.; Vecherin, Sergey N.; Wilson, D. Keith; Borden, Christian T.; Bettencourt, Elizabeth; Pettit, Chris L.

    2012-05-01

    Effective use of passive and active sensors for surveillance, security, and intelligence must consider terrain and atmospheric effects on the sensor performance. Several years ago, U.S. Army ERDC undertook development of software for modeling environmental effects on target signatures, signal propagation, and battlefield sensors for many signal modalities (e.g., optical, acoustic, seismic, magnetic, radio-frequency, chemical, biological, and nuclear). Since its inception, the software, called Environmental Awareness for Sensor and Emitter Employment (EASEE), has matured and evolved significantly for simulating a broad spectrum of signal-transmission and sensing scenarios. The underlying software design involves a flexible, object-oriented approach to the various stages of signal modeling from emission through processing into inferences. A sensor placement algorithm has also been built in for optimizing sensor selections and placements based on specification of sensor supply limitations, coverage priorities, and wireless sensor communication requirements. Some recent and ongoing enhancements are described, including modeling of active sensing scenarios and signal reflections, directivity of signal emissions and sensors, improved handling of signal feature dependencies, extensions to realistically model additional signal modalities such as infrared and RF, and XML-based communication with other calculation and display engines.

  4. Sweet clover poisoning

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sweet clover poisoning occurs when spoiled sweet clover (Melilotus officinalis and M. alva) hay or silage that contain dicumarol are consumed by livestock. This updated chapter is a succinct review of the clinical disease and pathologic lesions of poisoning. It also reviews current strategies and ...

  5. Suspected Pesticide Poisoning

    PubMed Central

    Sellar, Christine; Ferguson, Joyce A.

    1991-01-01

    Of 1125 calls to a regional poison control center about suspected pesticide poisonings, more than half concerned children younger than 6 years, most of whom had ingested small amounts and required no treatment other than drinking fluids. Adults represented a small proportion of victims, but were more likely to have consumed moderate or large quantities, to have symptoms, and to need referral. PMID:21228985

  6. Sweet clover poisoning

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sweet clover poisoning is a hemorrhagic disease produced when spoiled sweet clover (Melilotus officinalis and M. alba) hay or silage that contain dicumarol are consumed by livestock. This chapter reviews the clinical and pathologic lesions or poisoning. It also reviews current strategies and treat...

  7. Lead Poisoning in Children.

    ERIC Educational Resources Information Center

    Lin-Fu, Jane S.

    This publication is a guide to help social and health workers plan a preventive campaign against lead poisoning, a cause of mental retardation other neurological handicaps, and death among children. The main victims are 1- to 6-year-olds living in areas where deteriorating housing prevails. Among the causes of lead poisoning are: ingestion of…

  8. First High-Resolution Analysis of Phosgene 35CL2CO and 35CL37CLCO Fundamentals in the 250 - 480 wn Spectral Region

    NASA Astrophysics Data System (ADS)

    Kwabia Tchana, F.; Ndao, M.; Manceron, Laurent; Perrin, Agnes; Flaud, Jean-Marie; Lafferty, Walter

    2016-06-01

    Phosgene (COCl_2) is relatively more abundant in the stratosphere, but is also present in the troposphere in spite of a shorter lifetime (seventy days). Monitoring its concentration by remote sounding of the upper atmosphere is of importance, since some of its strong infrared absorptions, occurring in the important 8-12 μm atmospheric window, hinder the correct retrieval of Freon-11 concentration profiles. Indeed, the infrared absorptions used to retrieve this ozone depleting compound occur in the same spectral region. Phosgene, presents two fundamental bands in the 250 - 480 wn spectral region, with the lowest (ν_3) near 285 wn. These are responsible for hot bands, not yet analysed but of great importance for accurate modeling of the 5.47 μm (ν_1) and 11.75 μm (ν_5) spectral regions and consequently the correct retrieval of Freon-11 atmospheric absorption profiles. High-resolution absorption spectra of phosgene have been recorded at 0.00102 wn resolution in the 250-480 wn region by Fourier transform spectroscopy at synchrotron SOLEIL. Due to the spectral congestion, the spectra have been recorded at low temperature (197 K) using a 93.15 m optical path length cryogenic cell. This enables the first detailed far-infrared analyzes of the ν_3 and ν_6 bands of the 35Cl2CO and 35Cl37ClCO isotopologues of phosgene. Using a Watson-type Hamiltonian, it was possible to reproduce the upper state rovibrational infrared energy levels to within the experimental accuracy. The results will be presented in this talk. G. Toon, J.F. Blavier, B. Sen and B.J. Drouin, Geophys. Res. Lett., 28/14 (2001) 2835. F. Kwabia Tchana, F. Willaert, X. Landsheere, J.-M. Flaud, L. Lago, M. Chapuis, P. Roy and L. Manceron, Rev. Sci. Inst., 84 (2013) 093101.

  9. Look Out! It's Poison Ivy!

    ERIC Educational Resources Information Center

    Darlington, Elizabeth, Day

    1986-01-01

    Provides background information on poison ivy and offers suggestions for instructional activities. Includes illustrations of the varieties of poison ivy leaf forms and poison ivy look-alikes. Highlights interesting facts and cases associated with poison ivy and its relatives. (ML)

  10. Window cleaner poisoning

    MedlinePlus

    ... 2007:chap 32. Mycyk MB. Toxic alcohols. In: Adams JG, ed. Emergency Medicine . 2nd ed. Philadelphia, PA: ... AE. General approach to the poisoned patient. In: Adams JG, ed. Emergency Medicine . 2nd ed. Philadelphia, PA: ...

  11. Poisoning - fish and shellfish

    MedlinePlus

    ... poisoning, you may receive: Blood and urine tests EKG (electrocardiogram, or heart tracing) Fluids by IV (through ... and breathing machine (ventilator) Blood and urine tests EKG (electrocardiogram, or heart tracing) Fluids by IV (through ...

  12. Sodium bisulfate poisoning

    MedlinePlus

    ... in large amounts. This article discusses poisoning from swallowing sodium bisulfate. This article is for information only. ... Symptoms from swallowing more than a tablespoon of this acid may include: Burning pain in the mouth Chest pain from burns ...

  13. Cloth dye poisoning

    MedlinePlus

    ... poisonous ingredient in most household cloth dyes. Most common household cloth dyes are made from nonpoisonous substances, such as: Mild soaps Pigments Salts Although these substances are generally considered not dangerous, ...

  14. Poison Ivy Dermatitis

    MedlinePlus

    ... familiar skin rash. No one is born with sensitivity to Poison ivy, but if exposed enough most ... sensitized at some time and remain allergic. A sensitivity can change at any time. There's no way ...

  15. Occupational cyanide poisoning.

    PubMed

    Amizet, Loic; Pruvot, Gauthier; Remy, Sophie; Kfoury, Michel

    2011-01-01

    Cyanide poisoning has existed for centuries. In most cases, cyanide is combined with other toxic substances; for example with carbon monoxide in fire smoke. Cases of pure cyanide poisoning are rare, and usually due to accidental exposure. Their treatment is based on oxygenation and the infusion of hydroxocobalamin. The seriousness of this type of poisoning calls for a rapid and specific response, which demonstrates the usefulness of non-hospital based medical treatment. The authors report here the case of a man who was the victim of occupational poisoning with sodium cyanide and who was treated at the workplace by fire-fighters and the Service Mobile d'Urgence et Reanimation emergency ambulance service. PMID:22674698

  16. Tips to Prevent Poisonings

    MedlinePlus

    ... local take back programs in your community . Household Chemicals and Carbon Monoxide Always read the label before using a product that may be poisonous. Keep chemical products in their original bottles or containers. Do ...

  17. Potassium carbonate poisoning

    MedlinePlus

    Potassium carbonate is a white powder used to make soap, glass, and other items. This article discusses poisoning from swallowing or breathing in potassium carbonate. This article is for information only. Do ...

  18. Bracken fern poisoning

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bracken fern (Pteridium aquilinum) has worldwide distribution and in some areas dominated plant communities replacing desirable forages. Poisoning is identified as enzootic hematuria, bright blindness, and bracken staggers. This chapter reviews updates new information on the plant, the various poi...

  19. Poison plants (image)

    MedlinePlus

    ... exposure to sunlight, or by poor circulation, even stress. An example of contact dermatitis is the reaction of a sensitive person's skin to poison ivy, oak or sumac. Contact with these plants, which contain a chemical called urushiol, produces an ...

  20. Ethylene glycol poisoning

    MedlinePlus

    ... kidneys. The poisoning causes disturbances in the body's chemistry, including metabolic acidosis . The disturbances may be severe ... other tests such as: Arterial blood gas analysis Chemistry panel and liver function studies Chest x-ray ( ...

  1. Cedar leaf oil poisoning

    MedlinePlus

    Cedar leaf oil is made from some types of cedar trees. Cedar leaf oil poisoning occurs when someone swallows this substance. ... The substance in cedar leaf oil that can be harmful is thujone (a hydrocarbon).

  2. Mineral spirits poisoning

    MedlinePlus

    Mineral spirits are liquid chemicals used to thin paint and as a degreaser. Mineral spirits poisoning occurs ... be found in: Mineral spirits ( Stoddard solvent ) Some paints Some floor and furniture waxes and polishes Some ...

  3. The Poisons Project.

    ERIC Educational Resources Information Center

    Crawford, Barbara A.

    1998-01-01

    Details a project in which students explore and study the poisons in their environment by asking and finding answers to their own research questions. Includes some suggestions for involving students successfully in inquiry-based learning. (DDR)

  4. Hair dye poisoning

    MedlinePlus

    ... are: Arsenic Bismuth Denatured alcohol Lead ( lead poisoning ) Mercury Pyrogallol Silver Hair dyes may contain other harmful ... bleeding and infection. Continued exposure to lead or mercury can lead to permanent brain and nervous system ...

  5. Occupational cyanide poisoning.

    PubMed

    Amizet, Loic; Pruvot, Gauthier; Remy, Sophie; Kfoury, Michel

    2011-11-21

    Cyanide poisoning has existed for centuries. In most cases, cyanide is combined with other toxic substances; for example with carbon monoxide in fire smoke. Cases of pure cyanide poisoning are rare, and usually due to accidental exposure. Their treatment is based on oxygenation and the infusion of hydroxocobalamin. The seriousness of this type of poisoning calls for a rapid and specific response, which demonstrates the usefulness of non-hospital based medical treatment. The authors report here the case of a man who was the victim of occupational poisoning with sodium cyanide and who was treated at the workplace by fire-fighters and the Service Mobile d'Urgence et Reanimation emergency ambulance service.

  6. Occupational cyanide poisoning

    PubMed Central

    Amizet, Loic; Pruvot, Gauthier; Remy, Sophie; Kfoury, Michel

    2011-01-01

    Cyanide poisoning has existed for centuries. In most cases, cyanide is combined with other toxic substances; for example with carbon monoxide in fire smoke. Cases of pure cyanide poisoning are rare, and usually due to accidental exposure. Their treatment is based on oxygenation and the infusion of hydroxocobalamin. The seriousness of this type of poisoning calls for a rapid and specific response, which demonstrates the usefulness of non-hospital based medical treatment. The authors report here the case of a man who was the victim of occupational poisoning with sodium cyanide and who was treated at the workplace by fire-fighters and the Service Mobile d’Urgence et Reanimation emergency ambulance service. PMID:22674698

  7. Hydrofluoric acid poisoning

    MedlinePlus

    ... your skin or eyes, you may have: Blisters Burns Pain Vision loss Hydrofluoric acid poisoning can have ... urine tests Camera down the throat to see burns in the esophagus and the stomach (endoscopy) Fluids ...

  8. Transient receptor potential (TRP) channels as a therapeutic target for intervention of respiratory effects and lethality from phosgene.

    PubMed

    Andres, Devon; Keyser, Brian; Benton, Betty; Melber, Ashley; Olivera, Dorian; Holmes, Wesley; Paradiso, Danielle; Anderson, Dana; Ray, Radharaman

    2016-02-26

    Phosgene (CG), a toxic inhalation and industrial hazard, causes bronchoconstriction, vasoconstriction and associated pathological effects that could be life threatening. Ion channels of the transient receptor potential (TRP) family have been identified to act as specific chemosensory molecules in the respiratory tract in the detection, control of adaptive responses and initiation of detrimental signaling cascades upon exposure to various toxic inhalation hazards (TIH); their activation due to TIH exposure may result in broncho- and vasoconstriction. We studied changes in the regulation of intracellular free Ca(2+) concentration ([Ca(2+)]i) in cultures of human bronchial smooth muscle cells (BSMC) and human pulmonary microvascular endothelial cells (HPMEC) exposed to CG (16ppm, 8min), using an air/liquid interface exposure system. CG increased [Ca(2+)]i (p<0.05) in both cell types, The CG-induced [Ca(2+)]i was blocked (p<0.05) by two types of TRP channel blockers, SKF-96365, a general TRP channel blocker, and RR, a general TRPV (vanilloid type) blocker, in both BSMC and HPMEC. These effects correlate with the in vivo efficacies of these compounds to protect against lung injury and 24h lethality from whole body CG inhalation exposure in mice (8-10ppm×20min). Thus the TRP channel mechanism appears to be a potential target for intervention in CG toxicity. PMID:26562769

  9. American Association of Poison Control Centers

    MedlinePlus

    ... View all alerts right left National Poison Prevention Week is March 20-26! Be a part of ... is poison-proof. Read more › National Poison Prevention Week Congress established National Poison Prevention Week (NPPW) on ...

  10. Operational advantages of using Cyber Electronic Warfare (CEW) in the battlefield

    NASA Astrophysics Data System (ADS)

    Yasar, Nurgul; Yasar, Fatih M.; Topcu, Yucel

    2012-06-01

    While cyberspace is emerging as a new battlefield, conventional Electronic Warfare (EW) methods and applications are likely to change. Cyber Electronic Warfare (CEW) concept which merges cyberspace capabilities with traditional EW methods, is a new and enhanced form of the electronic attack. In this study, cyberspace domain of the battlefield is emphazised and the feasibility of integrating Cyber Warfare (CW) concept into EW measures is researched. The SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis method is used to state the operational advantages of using CEW concept in the battlefield. The operational advantages of CEW are assessed by means of its effects on adversary air defense systems, communication networks and information systems. Outstanding technological and operational difficulties are pointed out as well. As a result, a comparison of CEW concept and conventional EW applications is presented. It is concluded that, utilization of CEW concept is feasible at the battlefield and it may yield important operational advantages. Even though the computers of developed military systems are less complex than normal computers, they are not subjected to cyber threats since they are closed systems. This concept intends to show that these closed systems are also open to the cyber threats. As a result of the SWOT analysis, CEW concept provides Air Forces to be used in cyber operations effectively. On the other hand, since its Collateral Damage Criteria (CDC) is low, the usage of cyber electronic attack systems seems to grow up.

  11. Exploring Diversity at GCSE: Making a First World War Battlefields Visit Meaningful to All Students

    ERIC Educational Resources Information Center

    Philpott, Joanne; Guiney, Daniel

    2011-01-01

    Having already reflected on ways of improving their students' understanding of historical diversity at Key Stage 3, Joanne Philpott and Daniel Guiney set themselves the challenge of extending this to post-14 students by means of fieldwork activities at First World War battlefields sites. In addition, they wanted to link the study of past diversity…

  12. Poison control center - emergency number

    MedlinePlus

    For a POISON EMERGENCY call: 1-800-222-1222 ANYWHERE IN THE UNITED STATES This national hotline number will let you ... is a free and confidential service. All local poison control centers in the United States use this ...

  13. Acute organophosphorus poisoning.

    PubMed

    Chowdhary, Sheemona; Bhattacharyya, Rajasri; Banerjee, Dibyajyoti

    2014-04-20

    Acute organophosphorus poisoning continues to be a detrimental problem and a potential cause of mortality especially in developing countries. Inhibition of acetylcholinesterase enzyme is the main mechanism of toxicity of such pesticides and measurement of acetylcholinesterase activity is the commonly used laboratory diagnosis approved for the purpose. It is now proved beyond any doubt that early intervention is beneficial for cases of acute organophosphorus poisoning and, therefore, considerable current interest has been generated for development of point of care testing tool for screening of the same. However, to the best of our knowledge so far the matter is not reviewed from the view of point of care testing tool development. In this paper, this subject is reviewed highlighting the methodological aspects and point of care testing tool development in the context of organophosphorus poisoning.

  14. [Acute carbon monoxide poisoning].

    PubMed

    Raphaël, Jean-Claude

    2008-04-30

    Carbon monoxide (CO) poisoning is still complicated by a high mortality and morbidity rate. Diagnosis can be obvious but is most of time difficult and sometimes remained unknown. It is usually based on clinical signs and must be confirmed by assessment of CO level in room air or in patient's expired breathing or blood and detection of a source. Mild neurological sequelae are very common. Normobaric oxygen is the first line treatment. Comatose and pregnant patients must undergo hyperbaric oxygen. All CO poisoning has to be declared to sanitary authority, which will in turn conduct a technical inspection to remove the source. The patient must be informed that he is at risk of new poisoning and of neurological complications. Progress in prevention and research in therapeutics are needed in order to reduce CO related morbidity.

  15. [Electronic poison information management system].

    PubMed

    Kabata, Piotr; Waldman, Wojciech; Kaletha, Krystian; Sein Anand, Jacek

    2013-01-01

    We describe deployment of electronic toxicological information database in poison control center of Pomeranian Center of Toxicology. System was based on Google Apps technology, by Google Inc., using electronic, web-based forms and data tables. During first 6 months from system deployment, we used it to archive 1471 poisoning cases, prepare monthly poisoning reports and facilitate statistical analysis of data. Electronic database usage made Poison Center work much easier. PMID:24466697

  16. [Electronic poison information management system].

    PubMed

    Kabata, Piotr; Waldman, Wojciech; Kaletha, Krystian; Sein Anand, Jacek

    2013-01-01

    We describe deployment of electronic toxicological information database in poison control center of Pomeranian Center of Toxicology. System was based on Google Apps technology, by Google Inc., using electronic, web-based forms and data tables. During first 6 months from system deployment, we used it to archive 1471 poisoning cases, prepare monthly poisoning reports and facilitate statistical analysis of data. Electronic database usage made Poison Center work much easier.

  17. Cow dung powder poisoning.

    PubMed

    Sherfudeen, Khaja Mohideen; Kaliannan, Senthil Kumar; Dammalapati, Pavan Kumar

    2015-11-01

    Cow dung, which has germicidal property, was used in ancient days to clean living premises in South India. Nowadays, people are using commercially available synthetic cow dung powder. It is locally known as "saani powder" in Tamil Nadu. It is freely available in homes and is sometimes accidentally consumed by children. It is available in two colors - yellow and green. Cow dung powder poisoning is common in districts of Tamil Nadu such as Coimbatore, Tirupur, and Erode. We report two cases of yellow cow dung powder poisoning from our hospital. PMID:26730123

  18. Methylmercury Poisoning in Iraq

    ERIC Educational Resources Information Center

    Bakir, F.; And Others

    1973-01-01

    Discusses incidence of methylmercury poisoning throughout the world with increasing industrial and agricultural use of mercury compounds. Describes recent epidemic in Iraq resulting from use of wheat treated with methylmercurial fungicide. New data are presented on the toxicity of methylmercury and its metabolic fate in the human body. (JR)

  19. Lead Poisoning in Children.

    ERIC Educational Resources Information Center

    Boeckx, Roger L.

    1986-01-01

    Urban children are exposed to lead through the air they breathe, the water they drink, and the food and nonfood substances they ingest. The history, diagnosis, and treatment of lead poisoning in these children are discussed. Includes information on the toxicology of lead and the various risk classes. (JN)

  20. [Acute arsenic poisoning].

    PubMed

    Montelescaut, Etienne; Vermeersch, Véronique; Commandeur, Diane; Huynh, Sophie; Danguy des Deserts, Marc; Sapin, Jeanne; Ould-Ahmed, Mehdi; Drouillard, Isabelle

    2014-01-01

    Acute arsenic poisoning is a rare cause of suicide attempt. It causes a multiple organs failure caused by cardiogenic shock. We report the case of a patient admitted twelve hours after an ingestion of trioxide arsenic having survived thanks to a premature treatment.

  1. [Acute arsenic poisoning].

    PubMed

    Montelescaut, Etienne; Vermeersch, Véronique; Commandeur, Diane; Huynh, Sophie; Danguy des Deserts, Marc; Sapin, Jeanne; Ould-Ahmed, Mehdi; Drouillard, Isabelle

    2014-01-01

    Acute arsenic poisoning is a rare cause of suicide attempt. It causes a multiple organs failure caused by cardiogenic shock. We report the case of a patient admitted twelve hours after an ingestion of trioxide arsenic having survived thanks to a premature treatment. PMID:25486670

  2. Tainted Water, Poison Paint.

    ERIC Educational Resources Information Center

    Natale, Jo Anna

    1991-01-01

    Recent research shows lead poisoning is more widespread and even more dangerous to infants and young children than previously thought. A bill proposed in Congress would require schools and day-care centers to test for lead. Summarizes lead's health hazards and how to test drinking water. (MLF)

  3. Lead Poisoning in Children.

    ERIC Educational Resources Information Center

    Lin-Fu, Jane S.

    Designed as a public information pamphlet, the text discusses the problem of lead poisoning in children. The preventable nature of the problem is stressed as well as needed action on the part of the public, physicians and other health workers, and the legislators. The pamphlet emphasizes that each of these areas is essential in preventing death or…

  4. [Amitriptyline and imipramine poisoning].

    PubMed

    Paul, H; Ehrenthal, W; Wahlen, W

    1980-01-01

    Two cases of severe poisoning by tricyclic antidepressants (Amitriptylin, Imipramin) are reported. Both patients 3 and 11 years old children, developed a typical clinical picture with cardiovascular, neurological and atropine features. Beside a general supportive management, in one case physostigmin was used as antidote. Alternative treatments of enuresis in childhood are recommended.

  5. Age and criminal poisonings.

    PubMed

    Stankova, Evgenia; Gesheva, Margarita; Hubenova, Aneta

    2005-01-01

    We present a series of 8 cases of acute combined poisonings, occurred in an identical way in patients over 70 years of age for a period of 6 months. The way of exposure, characteristic of the clinical presentation, complications and the outcome of the intoxications, as well as the therapeutic approach is described. In all of the cases combined drug intoxication with benzodiazepines and opiates have been proved. The impact of the combination of two toxic substances: the first causing rapid and brief suppression of the consciousness and the second, causing prolonged continuation of the already suppressed consciousness, on the clinical course is discussed. The similarities in the circumstances of the exposure, clinical course of the poisonings, the identified toxic substances, lead to the consideration of criminal characteristic of the poisonings. The contact with the corresponding authorities brought off the disclosure of a group of criminals, committed the intentional intoxications with the aim of robbery. Age, with all its various characteristics, has been discussed as a factor for occurrence of criminal poisonings. PMID:16225098

  6. Puffer fish poisoning.

    PubMed Central

    Field, J

    1998-01-01

    Regarded by many as a delicacy, puffer fish (Lagocephalus scleratus) is a lethal source of food poisoning with a high mortality. It contains tetrodotoxin which can cause death by muscular paralysis, respiratory depression, and circulatory failure. A case of mild intoxication is reported and the literature reviewed. Images p336-a PMID:9785165

  7. First far-infrared high resolution analysis of the ν3 band of phosgene 35Cl2CO and 35Cl37ClCO

    NASA Astrophysics Data System (ADS)

    Ndao, M.; Perrin, A.; Kwabia Tchana, F.; Manceron, L.; Flaud, J. M.

    2016-08-01

    The high-resolution absorption spectra of phosgene (Cl2CO) has been recorded at 0.001 cm-1 resolution in the 250-350 cm-1 region by Fourier transform spectroscopy at synchrotron SOLEIL. To reduce the spectral congestion, the spectra have been recorded at low temperature (197 K) using a 93.14 m optical path length cryogenic cell. This enables the first detailed infrared analysis of the ν3 bands of the 35Cl2CO and 35Cl37ClCO isotopologues of phosgene. Using a Watson-type Hamiltonian, it was possible to reproduce the upper state rovibrational infrared energy levels, together with, for 35Cl2CO, the available microwave data in the 31 excited state (Yamamoto et al. 1984) to within their experimental accuracy. In this way, accurate rotational and centrifugal distortion constants together with the following band centers: ν0(ν3, 35Cl2CO) = 301.545622(17) cm-1 and ν0(ν3, 35Cl37ClCO) = 298.199194(81) cm-1, were derived for the ν3 bands of 35Cl2CO and 35Cl37ClCO.

  8. Commemoration and Preservation: An Administrative History of Big Hole National Battlefield.

    ERIC Educational Resources Information Center

    Catton, Theodore; Hubber, Ann

    Few places in the west are as evocative of the tragic story of the Indian Wars as Big Hole (Montana) National Battlefield. The site memorializes the bravery of the Nez Perce and U.S. soldiers and volunteers who fought there during the epic flight of the Nez Perce in 1877. Big Hole preserves the scene of one of the most famous battles of the Indian…

  9. Organophosphate and carbamate poisoning.

    PubMed

    Bardin, P G; van Eeden, S F; Moolman, J A; Foden, A P; Joubert, J R

    1994-07-11

    Organophosphate insecticides may cause serious poisoning either accidentally or by deliberate ingestion. Toxic symptoms are produced by acetylcholine accumulation at cholinergic receptors. Diagnosis is based on history of exposure or ingestion, symptoms and signs of cholinergic overactivity and a decrease in serum pseudocholinesterase levels. Following diagnosis, grading of disease severity may identify patients with serious poisoning who should receive treatment in intensive care using adequate doses of anticholinergic drugs. Complications, particularly ventricular arrhythmias, central nervous system depression or seizures, and respiratory failure, should be anticipated and treated. Relapse may occur after seemingly successful treatment. Public education with regard to symptoms of toxicity must be encouraged, and physicians must provide skilled treatment for a potentially lethal condition.

  10. Ciguatera poisoning in Vanuatu.

    PubMed

    Goodman, Anna; Williams, Thomas N; Maitland, Kathryn

    2003-02-01

    Ciguatera poisoning is endemic in many tropical and subtropical countries. We conducted a retrospective study of admissions to two hospitals on the islands of Vanuatu in the southwestern Pacific region. We estimated the annual hospital admission rate for fish poisoning to be 65 (95% confidence interval [CI] = 55-75)/100,000 population on the island of Santo and 29 (95% CI = 19-43)/100,000 population on the island of Ambae. Hospital admission was more common in males 20-29 years old. Death was a rare complication. In the face of increases in both tourism and in the global trade in tropical and exotic fish, physicians in both endemic and non-endemic areas should be familiar with the epidemiology and clinical features of this important condition.

  11. Lead poisoning in children.

    PubMed

    Dapul, Heda; Laraque, Danielle

    2014-08-01

    There is no safe lead level in children. Primary prevention is the most effective way to bring about the complete removal of lead from the environment and eliminate lead poisoning as a public health concern. The National Lead Information Center can be reached via the Internet at www.epa.gov/lead and www.hud.gov/lead, or via phone at 1-800-424-LEAD (5323).

  12. Poisons and fever.

    PubMed

    Gordon, C J; Rowsey, P J

    1998-02-01

    1. Dysfunction of the thermoregulatory system is one of many pathologies documented in experimental animals and humans exposed to toxic chemicals. The mechanism of action responsible for many types of poison-induced fevers is not understood. Some elevations in body temperature are attributed to the peripheral actions of some poisons that stimulate metabolic rate and cause a forced hyperthermia. Exposure to organophosphate (OP) pesticides and certain metal fumes appears to cause a prolonged, regulated elevation in body temperature (Tb). 2. Activation of cyclo-oxygenase (COX) and the production of prostaglandin (PG)E2 in central nervous system (CNS) thermoregulatory centres is required to elicit a fever. Activating the COX-PGE2 pathway by a poison may occur by one of three mechanisms: (i) induction of cell-mediated immune responses and the subsequent release of cytokines; (ii) induction of lipid peroxidation in the CNS; and (iii) direct neurochemical activation. 3. Radiotelemetric monitoring of core temperature in unstressed rodents has led to an experimental animal model of poison-induced fever. Rats administered the OP agents chlorpyrifos and diisopropyl fluorophosphate display an initial hypothermic response lasting approximately 24 h, followed by an elevation in diurnal core temperature for 24-72 h after exposure. The hyperthermia is apparently a result of the activation of the COX-PGE2 pathway because it is blocked by the anti-pyretic sodium salicylate. Overall, the delayed hyperthermia resulting from OP exposure involves activation of thermoregulatory pathways that may be similar to infection-mediated fever. PMID:9493505

  13. Lead Poison Detection

    NASA Technical Reports Server (NTRS)

    1976-01-01

    With NASA contracts, Whittaker Corporations Space Science division has developed an electro-optical instrument to mass screen for lead poisoning. Device is portable and detects protoporphyrin in whole blood. Free corpuscular porphyrins occur as an early effect of lead ingestion. Also detects lead in urine used to confirm blood tests. Test is inexpensive and can be applied by relatively unskilled personnel. Similar Whittaker fluorometry device called "drug screen" can measure morphine and quinine in urine much faster and cheaper than other methods.

  14. Homicidal arsenic poisoning.

    PubMed

    Duncan, Andrew; Taylor, Andrew; Leese, Elizabeth; Allen, Sam; Morton, Jackie; McAdam, Julie

    2015-07-01

    The case of a 50-year-old man who died mysteriously after being admitted to hospital is reported. He had raised the possibility of being poisoned prior to his death. A Coroner's post-mortem did not reveal the cause of death but this was subsequently established by post-mortem trace element analysis of liver, urine, blood and hair all of which revealed very high arsenic concentrations.

  15. [Acute phostoxin poisoning].

    PubMed

    Idali, B; Miguil, M; Moutawakkil, S; Bouaggad, A; Guartit, A; Abassi, O; Ben Aguida, M

    1995-04-01

    Phostoxin is a mixture of aluminium phosphide and ammonium carbonate. When exposed to water, it releases phosphorus hydrogen (PH3), a highly-poisonous gas. In Morocco, death rate from suicide due to self-administration of phostoxin pills is high. Clinical signs include abrupt digestive and nervous disorders. Pulmonary oedema or cardiogenic shock dominate early prognosis. Liver and renal damage is secondary. Prevention requires both legal constraints and regulation of sales. PMID:7761363

  16. Chronic arsenic poisoning.

    PubMed

    Hall, Alan H

    2002-03-10

    Symptomatic arsenic poisoning is not often seen in occupational exposure settings. Attempted homicide and deliberate long-term poisoning have resulted in chronic toxicity. Skin pigmentation changes, palmar and plantar hyperkeratoses, gastrointestinal symptoms, anemia, and liver disease are common. Noncirrhotic portal hypertension with bleeding esophageal varices, splenomegaly, and hypersplenism may occur. A metallic taste, gastrointestinal disturbances, and Mee's lines may be seen. Bone marrow depression is common. 'Blackfoot disease' has been associated with arsenic-contaminated drinking water in Taiwan; Raynaud's phenomenon and acrocyanosis also may occur. Large numbers of persons in areas of India, Pakistan, and several other countries have been chronically poisoned from naturally occurring arsenic in ground water. Toxic delirium and encephalopathy can be present. CCA-treated wood (chromated copper arsenate) is not a health risk unless burned in fireplaces or woodstoves. Peripheral neuropathy may also occur. Workplace exposure or chronic ingestion of arsenic-contaminated water or arsenical medications is associated with development of skin, lung, and other cancers. Treatment may incklude the use of chelating agents such as dimercaprol (BAL), dimercaptosuccinic acid (DMSA), and dimercaptopanesulfonic acid (DMPS).

  17. Endrin-food-poisoning

    PubMed Central

    Weeks, D. E.

    1967-01-01

    Between 3 June and 15 July 1967 four explosive outbreaks of acute poisoning with the insecticide endrin occurred in Doha in Qatar and Hofuf in Saudi Arabia. Altogether 874 persons were hospitalized and 26 died. It is estimated that many others were poisoned whose symptoms were not so severe as to cause them to seek medical care or to enter hospital. The author describes the course of the outbreaks and the measures taken to ascertain their cause and prevent their extension and recurrence. It was found that the victims had eaten bread made from flour contaminated with endrin. In two different ships, both of them loaded and off-loaded at different ports, flour and endrin had been stowed in the same hold, with the endrin above the flour. In both ships the endrin containers had leaked and penetrated the sacks of flour which was later used to make bread. These two unconnected but nearly simultaneous mass poisonings emphasize the importance of regulating the carriage of insecticides and other toxic chemicals in such a way as to prevent the contamination of foodstuffs and similar substances during transport; both the World Health Organization and the Inter-Governmental Maritime Consultative Organization are working towards the establishment of regulations and practices to that end. PMID:5301732

  18. OXYGEN POISONING IN MAMMALS.

    PubMed

    Binger, C A; Faulkner, J M; Moore, R L

    1927-04-30

    1. Oxygen in concentrations of over 70 per cent of an atmosphere is poisonous to dogs, rabbits, guinea pigs and mice. 2. The poisonous effects manifest themselves in drowsiness, anorexia, loss of weight, increasing dyspnea, cyanosis and death from oxygen want. 3. The cause of oxygen want is a destructive lesion of the lungs. 4. The lesion may be characterized grossly as an hemorrhagic edema. Microscopically there is to be seen in varying degrees of intensity (a) capillary engorgement with hemorrhage, (b) the presence of interstitial and intraalveolar serum, (c) hypertrophy and desquamation of alveolar cells, (d) interstitial and alveolar infiltration of mononuclear cells. 5. The type of tissue reaction is not characteristic of an infectious process and no organisms have been recovered at autopsy from the heart's blood or from lung puncture. 6. The poisonous effects of inhalations of oxygen-rich mixtures do not appear to be related to impurities in the oxygen, nor are they related to faulty ventilation, excessive moisture or increased carbon dioxide in the atmosphere of the chambers in which the experimental animals were confined. PMID:19869294

  19. Chemical and Biological Summer Poisons

    PubMed Central

    Lees, Ronald E. M.

    1972-01-01

    Summer has its own special poisoning hazards for the vacationer, gardener or outdoorsman. Because of the comparative variety of accidental human poisonings from contact with these seasonal toxic substances, either artificial or natural, many family physicians are unfamiliar with their effects. Some of us, unfortunately, will be called upon to deal with them over the next few months. This article highlights some of the hazards, outlines their toxicology and summarizes the treatment of the poisoned patient. PMID:20468771

  20. Moonshine-related arsenic poisoning.

    PubMed

    Gerhardt, R E; Crecelius, E A; Hudson, J B

    1980-02-01

    Twelve sequential cases of arsenic poisoning were reviewed for possible sources of ingestion. Contaminated illicit whiskey (moonshine) appeared to be the source in approximately 50% of the patients. An analysis of.confiscated moonshine revealed that occasional specimens contained high levels of arsenic as a contaminant. Although arsenic poisoning occurs relatively infrequently, contaminated moonshine may be an important cause of the poisoning in some areas of the country.

  1. The affliction of Job: poisoned!

    PubMed

    Gorman, S; Kaplan, D L

    1999-01-01

    The story of Job has been an inspiration for centuries to those familiar with the story. It has also been a source of curiosity as to what affliction he suffered. A critical reappraisal of the clinical manifestations of his illness support the contention that he was a victim of poisoning. There is historical evidence to support that the poison was available in his time and already in use for poisoning. Finally, there is even documentation in the story of Job as to the identity of his poisoner. PMID:9922031

  2. Household Safety: Preventing Poisoning (For Parents)

    MedlinePlus

    ... How Do I Get My Child Tested for Lead Poisoning? What You Need to Know in an Emergency ... Aid: Poisoning First-Aid Kit Emergency Contact Sheet Lead Poisoning Childproofing and Preventing Household Accidents Babysitting: Dealing With ...

  3. The power of poison: pesticide poisoning of Africa's wildlife.

    PubMed

    Ogada, Darcy L

    2014-08-01

    Poisons have long been used to kill wildlife throughout the world. An evolution has occurred from the use of plant- and animal-based toxins to synthetic pesticides to kill wildlife, a method that is silent, cheap, easy, and effective. The use of pesticides to poison wildlife began in southern Africa, and predator populations were widely targeted and eliminated. A steep increase has recently been observed in the intensity of wildlife poisonings, with corresponding population declines. However, the majority of poisonings go unreported. Under national laws, it is illegal to hunt wildlife using poisons in 83% of African countries. Pesticide regulations are inadequate, and enforcement of existing legislation is poor. Few countries have forensic field protocols, and most lack storage and testing facilities. Methods used to poison wildlife include baiting carcasses, soaking grains in pesticide solution, mixing pesticides to form salt licks, and tainting waterholes. Carbofuran is the most widely abused pesticide in Africa. Common reasons for poisoning are control of damage-causing animals, harvesting fish and bushmeat, harvesting animals for traditional medicine, poaching for wildlife products, and killing wildlife sentinels (e.g., vultures because their aerial circling alerts authorities to poachers' activities). Populations of scavengers, particularly vultures, have been decimated by poisoning. Recommendations include banning pesticides, improving pesticide regulations and controlling distribution, better enforcement and stiffer penalties for offenders, increasing international support and awareness, and developing regional pesticide centers.

  4. The power of poison: pesticide poisoning of Africa's wildlife.

    PubMed

    Ogada, Darcy L

    2014-08-01

    Poisons have long been used to kill wildlife throughout the world. An evolution has occurred from the use of plant- and animal-based toxins to synthetic pesticides to kill wildlife, a method that is silent, cheap, easy, and effective. The use of pesticides to poison wildlife began in southern Africa, and predator populations were widely targeted and eliminated. A steep increase has recently been observed in the intensity of wildlife poisonings, with corresponding population declines. However, the majority of poisonings go unreported. Under national laws, it is illegal to hunt wildlife using poisons in 83% of African countries. Pesticide regulations are inadequate, and enforcement of existing legislation is poor. Few countries have forensic field protocols, and most lack storage and testing facilities. Methods used to poison wildlife include baiting carcasses, soaking grains in pesticide solution, mixing pesticides to form salt licks, and tainting waterholes. Carbofuran is the most widely abused pesticide in Africa. Common reasons for poisoning are control of damage-causing animals, harvesting fish and bushmeat, harvesting animals for traditional medicine, poaching for wildlife products, and killing wildlife sentinels (e.g., vultures because their aerial circling alerts authorities to poachers' activities). Populations of scavengers, particularly vultures, have been decimated by poisoning. Recommendations include banning pesticides, improving pesticide regulations and controlling distribution, better enforcement and stiffer penalties for offenders, increasing international support and awareness, and developing regional pesticide centers. PMID:24716788

  5. OCCUPATIONAL CARBAMATE POISONING IN THAILAND.

    PubMed

    Tongpoo, Achara; Sriapha, Charuwan; Wongvisawakorn, Sunun; Rittilert, Panee; Trakulsrichai, Satariya; Wananukul, Winai

    2015-07-01

    Carbamate insecticide is a leading cause of poisoning in Thailand. The objective of this study was to characterize the clinical manifestations and modes of occupational exposure in carbamate poisoning cases. We retrospectively studied all the cases of carbamate poisoning due to occupational exposure recorded in the Ramathibodi Poison Center Toxic Exposure Surveillance system during 2005 to 2010. Demographic data, clinical manifestations and severity were analyzed statistically. During the study period, 3,183 cases were identified, of which 170 (5.3%) were deemed to be due to occupational exposure. Ninety-six cases (56.5%) and 35 cases (20.6%) were poisoned by carbofuran and methomyl, respectively. Carbofuran is sold as a 3% grain and applied by sowing; methomyl is sold as a liquid and is applied by spraying. The majority of poisoned patients did not wear personal protective equipment (PPE) while applying the carbamates. The clinical manifestations of occupational carbofuran poisoning recorded were nausea and vomiting (82.3%), headaches (56.3%) and miosis (19.8%). The clinical manifestations of methomyl poisoning were nausea and vomiting (74.3%), headaches (57.1%) and palpitations (11.4%). Most patients in both groups had mild symptoms. Only one case in each group required endotracheal intubation and mechanical ventilation support. There were no deaths and the lengths of hospitalization ranged from 2 hours to 2 days. Occupational carbamate poisoning cases in our series were mostly mild and the patients recovered quickly. There were only rare cases of serious symptoms. Lack of knowledge and inadequate PPE were the major factors contributing to occupational poisoning. Educating agricultural workers about correct precautions and pesticide use could minimize this type of poisoning.

  6. Poisonous snakebite in Utah.

    PubMed

    Plowman, D M; Reynolds, T L; Joyce, S M

    1995-12-01

    A retrospective study was done of poisonous snakebite in Utah to determine the current epidemiology and scope of treatment, reviewing emergency department logs and other sources statewide for a 69-month period. Of 61 cases of poisonous snakebite identified, 13 occurred in snake hobbyists or venom laboratory personnel and were considered nonaccidental, and 48 were inflicted by native noncaptive snakes. These bites were considered accidental, and all were presumed to be from rattlesnakes. Nearly three fourths of the victims were male, ranging in age from 2 to 56 years (mean, 22 years). Most accidental bites occurred in areas of high human populations, during the summer months, in the afternoon or evening hours, and during recreational activities. Of the 48 bites, 11 (23%) were provoked. Two thirds of bites were on the upper extremities, and a third were on the lower extremities. More than half of the victims had no first-aid treatment recorded. Of those who did receive first aid, many were subjected to possibly harmful treatments, including tourniquets and ice application. The median time to a hospital was 68 minutes, with a range of 15 to 440 minutes. Swelling and discoloration were the most common signs and pain and paresthesia the most common symptoms. Half the bites resulted in minimal or no envenomation, 17 (35%) produced moderate envenomation, and 6 (12%) severe envenomation. Most patients with moderate or severe envenomation received antivenin, but the dosages given were usually less than recommended dosages. Five patients received surgical treatment based on clinical findings. One child died in a snake-handling incident. Long-term morbidity was unknown due to lack of follow-up. The Utah Poison Control Center was poorly utilized as a reporting and informational resource. PMID:8553638

  7. Acute lead arsenate poisoning.

    PubMed

    Tallis, G A

    1989-12-01

    Three cases of acute lead arsenate poisoning which occurred in South Australia during a 12 month interval are described. The case reports demonstrate a number of features of the characteristic clinical syndrome which may follow ingestion of lead arsenate. The recommended management is immediate gastric lavage and subsequent chelation therapy with calcium EDTA and dimercaprol. Early gastric lavage may prevent significant lead absorption. However, arsenic acid (produced in the stomach when lead arsenate reacts with hydrochloric acid) is relatively water soluble and prompt gastric lavage is unlikely to prevent extensive arsenic absorption. It remains controversial as to whether chelation with dimercaprol prevents arsenical neuropathy.

  8. Complications of quinine poisoning.

    PubMed

    Boland, M E; Roper, S M; Henry, J A

    1985-02-16

    Of 165 patients admitted to hospital with acute quinine poisoning 70 (42%) had visual symptoms. 19 were left with a permanent visual deficit, though none was left completely blind. 5 patients died. Bilateral stellate ganglion block was carried out on 34 patients with impaired visual acuity or blindness, but an improvement of symptoms was reported in only 4 cases. It is concluded that stellate ganglion blockade is not effective enough to justify its regular use in quinine-induced amblyopia. Quinine overdose can have serious consequences, and the drug should not be prescribed indiscriminately. PMID:2857431

  9. [Bromadiolone poisoning in foxes].

    PubMed

    Kupper, J; Grobosch, T; Kistler, R; Sydler, T; Naegeli, H

    2006-08-01

    Bromadiolone is an anticoagulant rodenticide that inhibits the reactivation of vitamin K1 by the enzyme vitamin K1-epoxide reductase. The present case report originated from the application of bromadiolone against water voles (Arvicola terrestris) in northeastern Switzerland. At least 40 foxes (Vulpes vulpes) were found dead after the inappropriate use of a bait that contained 0.02 % bromadiolone. Anticoagulant rodenticide poisoning was suspected on the basis of the postmortem examination and subsequently confirmed by the detection ofbromadiolone both in the blood and in samples from thoracic and abdominal fluids. PMID:16933704

  10. The development of the norm against the use of poison: what literature tells us.

    PubMed

    Moon, John Ellis van Courtland

    2008-03-01

    The use of chemical and biological weapons on the battlefield is considered by most commentators--and by international law--as more abhorrent than the use of nearly all other weapons, including ones meant either to kill secretly or to kill terribly, as do fire or burial alive. I ask why this is so. I explore this question through the study of imagery patterns in Western literature and campaigns against food contamination and environmental pollution. I find that the norm against chemical and biological weapons builds upon a taboo against poisons, a prohibition widely accepted in military manuals as distinguishing soldierly conduct from criminal conduct, especially those forms of conduct made criminal by the employment of treachery, invisibility, and transformation. PMID:19213304

  11. Scombroid Poisoning: A Practical Approach.

    PubMed

    Guergué-Díaz de Cerio, O; Barrutia-Borque, A; Gardeazabal-García, J

    2016-09-01

    Scombroid poisoning is a common cause of food poisoning worldwide. It is caused by ingestion of oily fish contaminated with bacteria that trigger the formation of high concentrations of histamine. Scombroid poisoning manifests mainly as a skin complaint (flushing that spreads downward and/or an erythematous urticarial rash affecting the face and upper trunk). Although the clinical course is usually self-limiting and benign, vascular compromise, bronchospasm, and arrhythmias have been described. It is important to establish a differential diagnosis that includes conditions such as fish allergy. Oral antihistamines are the mainstay of treatment. Scombroid poisoning is best prevented by refrigerating fish properly. The practical review of scombroid poisoning provided here is intended for dermatologists. PMID:27133773

  12. Scombroid Poisoning: A Practical Approach.

    PubMed

    Guergué-Díaz de Cerio, O; Barrutia-Borque, A; Gardeazabal-García, J

    2016-09-01

    Scombroid poisoning is a common cause of food poisoning worldwide. It is caused by ingestion of oily fish contaminated with bacteria that trigger the formation of high concentrations of histamine. Scombroid poisoning manifests mainly as a skin complaint (flushing that spreads downward and/or an erythematous urticarial rash affecting the face and upper trunk). Although the clinical course is usually self-limiting and benign, vascular compromise, bronchospasm, and arrhythmias have been described. It is important to establish a differential diagnosis that includes conditions such as fish allergy. Oral antihistamines are the mainstay of treatment. Scombroid poisoning is best prevented by refrigerating fish properly. The practical review of scombroid poisoning provided here is intended for dermatologists.

  13. Anticholinesterase insecticide poisoning.

    PubMed

    Mackey, C L

    1982-01-01

    Anticholinesterase insecticides can be lethal, especially to small children. Prevention, not treatment, is the key to lowering the mortality rate. However, treatment, when necessary, can be effective if the poisoning agent is identified quickly as an anticholinesterase insecticide and therapy is begun immediately and aggressively. Large doses (up to 5 gm) of atropine, which block the parasympathetic effects of the poison, in conjunction with pralidoxime, a cholinesterase regenerator, need to be administered, second only in priority to establishing an airway. The second line of attack after adequate atropinization is supportive. Assistance with ventilation is individualized according to the degree of patient need. Intake with cautiously vigorous fluid therapy and output via Foley catheter are essential. Gastric lavage, seizure precautions and control as necessary, good body hygiene, and frequent turning are also part of necessary nursing intervention. Prognosis is fairly good if improvement is shown after therapy is begun. Maintaining adequate atropinization seems to be difficult yet essential to the success of the treatment and a good prognosis for the patient. PMID:6921196

  14. [Arsenic - Poison or medicine?].

    PubMed

    Kulik-Kupka, Karolina; Koszowska, Aneta; Brończyk-Puzoń, Anna; Nowak, Justyna; Gwizdek, Katarzyna; Zubelewicz-Szkodzińska, Barbara

    2016-01-01

    Arsenic (As) is commonly known as a poison. Only a few people know that As has also been widely used in medicine. In the past years As and its compounds were used as a medicine for the treatment of such diseases as diabetes, psoriasis, syphilis, skin ulcers and joint diseases. Nowadays As is also used especially in the treatment of patients with acute promyelocytic leukemia. The International Agency for Research on Cancer (IARC) has recognized arsenic as an element with carcinogenic effect evidenced by epidemiological studies, but as previously mentioned it is also used in the treatment of neoplastic diseases. This underlines the specificity of the arsenic effects. Arsenic occurs widely in the natural environment, for example, it is present in soil and water, which contributes to its migration to food products. Long exposure to this element may lead to liver damages and also to changes in myocardium. Bearing in mind that such serious health problems can occur, monitoring of the As presence in the environmental media plays a very important role. In addition, the occupational risk of As exposure in the workplace should be identified and checked. Also the standards for As presence in food should be established. This paper presents a review of the 2015 publications based on the Medical database like PubMed and Polish Medical Bibliography. It includes the most important information about arsenic in both forms, poison and medicine.

  15. Organochlorine poisoning of herons

    USGS Publications Warehouse

    Ohlendorf, H.M.; Swineford, D.M.; Locke, L.N.

    1979-01-01

    Over a period of years interested individuals have submitted many dead or moribund herons of various species to our laboratory to learn whether the birds had been affected by diseases or organochlorine poisoning. Residue concentrations in carcasses of birds and mammals are considered the best measure of sublethal exposure, whereas residues in brains are best to use for diagnosing death by most organochlorine chemicals.... The purpose of the present paper is to document the occurrence and concentration of organochlorine residues in the brains of herons from various areas in the United States. By comparing these residue concentrations with laboratory-determined diagnostic lethal levels, we conclude that some herons were killed by organochlorine poisoning; others were at least seriously endangered by the residues they carried. Complete results of carcass analyses for these and other herons, as well as further details? on residues in brains, will be reported elsewhere. Overall, we analyzed carcasses or brains of more than 70 herons found dead or moribund and 36 others taken in planned collections. Residue levels in carcasses of many herons were not high enough to warrant analysis of brains. In the present paper we compare carcass and brain residues of dieldrin in 23 herons of which both carcass and brain were analyzed.

  16. [Poisonings in pregnancy].

    PubMed

    Schaefer, C; Hoffmann-Walbeck, P

    2012-03-01

    Attempted suicides and poisonings in pregnancy are a challenge for health care professionals because of the unknown effects of the toxic agent and the antidote therapy on the unborn. In case of intoxication, the malformation risk is often overestimated. In contrast, pertinent data show that the risk is not very high as long as the drug is not known as a teratogen and the mother's health is not substantially impaired. This applies to suicide attempts with acetaminophen, iron-containing products, and multidrug overdoses with psychopharmaceuticals as well as snake and spider bites and the ingestion of poisonous mushrooms. It is of utmost importance that the pregnant patient receives the same detoxification and supportive therapy following pertinent guidelines as a non-pregnant patient. The fetus should be followed-up by ultrasound with special focus on its vital parameters, movement pattern, and normal growth and organ differentiation. As long as the maternal health status is not substantially impaired, there is no indication to discuss elective termination of pregnancy "for toxicological reasons". PMID:22349530

  17. COMBAT: mobile-Cloud-based cOmpute/coMmunications infrastructure for BATtlefield applications

    NASA Astrophysics Data System (ADS)

    Soyata, Tolga; Muraleedharan, Rajani; Langdon, Jonathan; Funai, Colin; Ames, Scott; Kwon, Minseok; Heinzelman, Wendi

    2012-05-01

    The amount of data processed annually over the Internet has crossed the zetabyte boundary, yet this Big Data cannot be efficiently processed or stored using today's mobile devices. Parallel to this explosive growth in data, a substantial increase in mobile compute-capability and the advances in cloud computing have brought the state-of-the- art in mobile-cloud computing to an inflection point, where the right architecture may allow mobile devices to run applications utilizing Big Data and intensive computing. In this paper, we propose the MObile Cloud-based Hybrid Architecture (MOCHA), which formulates a solution to permit mobile-cloud computing applications such as object recognition in the battlefield by introducing a mid-stage compute- and storage-layer, called the cloudlet. MOCHA is built on the key observation that many mobile-cloud applications have the following characteristics: 1) they are compute-intensive, requiring the compute-power of a supercomputer, and 2) they use Big Data, requiring a communications link to cloud-based database sources in near-real-time. In this paper, we describe the operation of MOCHA in battlefield applications, by formulating the aforementioned mobile and cloudlet to be housed within a soldier's vest and inside a military vehicle, respectively, and enabling access to the cloud through high latency satellite links. We provide simulations using the traditional mobile-cloud approach as well as utilizing MOCHA with a mid-stage cloudlet to quantify the utility of this architecture. We show that the MOCHA platform for mobile-cloud computing promises a future for critical battlefield applications that access Big Data, which is currently not possible using existing technology.

  18. Use of individual auto-injector kits ‘IZAS-05’ on the contemporary battlefield

    PubMed Central

    Ziemba, Radosław

    2012-01-01

    Summary In crisis situations, such as transportation catastrophes, terrorist attacks or contamination with chemical warfare agents, it is crucial to properly organize and sensibly conduct rescue operations. Among chemical warfare agents, the most toxic ones are the derivatives of organophosphorus compounds. An individual auto-injector kit ‘IZAS-05’ contains auto-injectors, which are devices designed for intramuscular administration of drugs in self-aid or buddy-aid on the battlefield. This paper describes in detail the components of the ‘IZAS-05’ kit, as well as its mode of use and possible contraindications. PMID:22207129

  19. [Subacute arsenic poisoning].

    PubMed

    Ghariani, M; Adrien, M L; Raucoules, M; Bayle, J; Jacomet, Y; Grimaud, D

    1991-01-01

    A cas is reported of a 23-year-old man who voluntarily took a massive dose of arsenic (at least 8 g). In spite of the ingested amount and the acute nature of the poisoning, the patient survived 8 days. Gastrointestinal, neurologic and cardiac features were predominant including nausea, vomiting, choleroid diarrhoea, encephalopathy, peripheral neuropathy, and finally a fatal toxic cardiomyopathy. Metabolic acidosis, moderate cytolysis and an anticoagulant effect were also observed. This unique characteristic was partly due to a circulating anticoagulant with prothrombinase activity, as well as direct antivitamin K activity. Postmortem examination revealed: a congestive oesophagitis; a necrosing gastritis involving all the stomach wall; diffuse hepatic steatosis; skin lesions with vascular congestion and dermoepidermal detachment; discrete subepicardial congestive lesions. Arsenic was found in all tissues.

  20. Cleistanthus collinus poisoning

    PubMed Central

    Chrispal, Anugrah

    2012-01-01

    Cleistanthus collinus, a toxic shrub, is used for deliberate self-harm in rural South India. MEDLINE (PUBMED) and Google were searched for published papers using the search/ MeSH terms “Cleistanthus collinus,” “Euphorbiaceae,” “Diphyllin,” “Cleistanthin A,” Cleistanthin B” and “Oduvanthalai.” Non-indexed journals and abstracts were searched by tracing citations in published papers. The toxic principles in the leaf include arylnaphthalene lignan lactones — Diphyllin and its glycoside derivatives Cleistanthin A and B. Toxin effect in animal models demonstrate neuromuscular blockade with muscle weakness, distal renal tubular acidosis (dRTA) and type 2 respiratory failure with conflicting evidence of cardiac involvement. Studies suggest a likely inhibition of thiol/thiol enzymes by the lignan-lactones, depletion of glutathione and ATPases in tissues. V-type H+ ATPase inhibition in the renal tubule has been demonstrated. Mortality occurs in up to 40% of C. collinus poisonings. Human toxicity results in renal tubular dysfunction, commonly dRTA, with resultant hypokalemia and normal anion gap metabolic acidosis. Aggressive management of these metabolic derangements is crucial. Acute respiratory distress syndrome (ARDS) is seen in severe cases. Cardiac rhythm abnormalities have been demonstrated in a number of clinical studies, though the role of temporary cardiac pacemakers in reducing mortality is uncertain. Consumption of decoctions of C. collinus leaves, hypokalemia, renal failure, severe metabolic acidosis, ARDS and cardiac arrhythmias occur in severe poisonings and predict mortality. Further study is essential to delineate mechanisms of organ injury and interventions, including antidotes, which will reduce mortality. PMID:22787347

  1. Development of a high-fidelity simulation capability for battlefield acoustics.

    SciTech Connect

    Aldridge, David Franklin; Marlin, David H.; Ostashev, Vladimir E.; Liu, Lanbo; Symons, Neill Phillip; Moran, Mark L.; Wilson, D. Keith

    2003-07-01

    Findings are presented from the first year of a joint project between the U.S. Army Engineer Research and Development Center, the U.S. Army Research Laboratory, and the Sandia National Laboratories. The purpose of the project is to develop a finite-difference, time-domain (FDTD) capability for simulating the acoustic signals received by battlefield acoustic sensors. Many important effects, such as scattering from trees and buildings, interactions with dynamic atmospheric wind and temperature fields, and nonstationary target properties, can be accommodated by the simulation. Such a capability has much potential for mitigating the need for costly field data collection and furthering the development of robust identification and tracking algorithms. The FDTD code is based on a carefully derived set of first-order differential equations that is more general and accurate than most current sound propagation formulations. For application to three-dimensional problems of practical interest in battlefield acoustics, the code must be run on massively parallel computers. Some example computations involving sound propagation in a moving atmosphere and propagation in the presence of trees and barriers are presented.

  2. Development of a lightweight portable ventilator for far-forward battlefield combat casualty support

    NASA Astrophysics Data System (ADS)

    Cutchis, Protagoras N.; Smith, Dexter G.; Ko, Harvey W.; Wiesmann, William P.; Pranger, L. Alex

    1999-07-01

    Immediate medical provision substantially reduces the number of fatalities sustained during military operations. However, the shift from large-scale regional conflicts to smaller peacekeeping and humanitarian missions has reduced the military medical support infrastructure. Civilian emergency medical services have long emphasized the 'golden hour' during which a patient must receive definitive medical attention. Without on-scene medical support, injured soldiers must be transported significant distances before receiving advanced medical care, and rapid transport to a medical facility is not always a viable option. Technological solutions enable military medics to deliver advanced medical care on the battlefield. We report here on the development of a small lightweight portable respirator for the treatment of far- forward battlefield casualties. The Far Forward Life Support System (FFLSS) utilizes a combination of COTS (commercial off the shelf) components and custom designed systems to provide ventilatory support to injured combatants. It also incorporates a small IV fluid pump and IV fluids for resuscitation. A microcompressor control system monitors both system performance and patient parameters for system control. Telemetry to a pager-like device worn by the front line medic alerts of any anomalies in ventilator or patient parameters, which will add greatly to triage decisions and resource management. Novel elements of the FLSS design include oxygen generation, low-pressure air generation, available patient suction, and the absence of any high pressure air cylinders. A prototype developed for animal testing will be described in detail as well as further design requirements for the human rated prototype.

  3. [Accidental poisoning and test for it].

    PubMed

    Sakamoto, Namiko; Kamijo, Yoshito; Soma, Kazui

    2008-11-30

    There are many dangerous materials which cause poisoning, toxins or poisons, in our lives. We may suddenly suffer from the effects of these materials by inhalation or ingestion before we are aware of the risk. It is very important to identify toxins or poisons to prevent poisoning and treat the poisoned patients. We have to learn from previous accidents the way to resolve future problems.

  4. Nuclear battlefields

    SciTech Connect

    Arkin, W.M.; Fieldhouse, R.W.

    1985-01-01

    This book provides complete data on the nuclear operations and research facilities in the U.S.A., the U.S.S.R., France, China and the U.K. It describes detailed estimates on the U.S.S.R.'s nuclear stockpile for over 500 locations. It shows how non-nuclear countries cooperate with the world-wide war machine. And it maps the U.S. nuclear facilities from Little America, WY, and Charleston, SC, to the battleships patroling the world's oceans and subs stalking under the sea. The data were gathered from unclassified sources through the Freedom of Information Act, from data supplied to military installations, and from weapons source books. It provides guidance for policymakers, government and corporate officials.

  5. Battlefield MRI

    SciTech Connect

    Espy, Michelle

    2015-06-01

    Magnetic Resonance Imaging is the best method for non-invasive imaging of soft tissue anatomy, saving countless lives each year. It is regarded as the gold standard for diagnosis of mild to moderate traumatic brain injuries. Furthermore, conventional MRI relies on very high, fixed strength magnetic fields (> 1.5 T) with parts-per-million homogeneity, which requires very large and expensive magnets.

  6. Oil-based paint poisoning

    MedlinePlus

    Hydrocarbons are the primary poisonous ingredient in oil paints. Some oil paints have heavy metals such as ... Gummin DD. Hydrocarbons. In: Nelson LS, Lewin NA, Howland MA, et al., eds. Goldfrank's Toxicologic Emergencies . 9th ed. New York, NY: ...

  7. Piperonyl butoxide with pyrethrins poisoning

    MedlinePlus

    Borron, SW. Pyrethrins, repellants, and other pesticides. In: Shannon MW, Borron SW, Burns MJ, eds. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose . 4th ed. Philadelphia, PA: ...

  8. Lead poisoning from Ayurvedic medicines.

    PubMed

    Tsutsui, Rayji S; Van Schalkwyk, Johan; Spriggs, David

    2013-05-10

    A case of lead poisoning with established exposure to Ayurvedic medicines is presented. This patient migrated from India to New Zealand 8 years previously. He regularly visits India where he purchases "herbal remedies" for his wellbeing.

  9. Antidotes for acute cyanide poisoning.

    PubMed

    Borron, Stephen W; Baud, Frederic J

    2012-08-01

    Cyanide poisoning can present in multiple ways, given its widespread industrial use, presence in combustion products, multiple physical forms, and chemical structures. The primary target of toxicity is mitochondrial cytochrome oxidase. The onset and severity of poisoning depend on the route, dose, physicochemical structure and other variables. Common poisoning features include dyspnea, altered respiratory patterns, abnormal vital signs, altered mental status, seizures, and lactic acidosis. Our present knowledge supports cyanide poisoning treatment based on excellent supportive care with adjunctive antidotal therapy. Multiple antidotes exist and vary in regional availability. All currently marketed antidotes appear to be effective. Antidotal mechanisms include chelation, formation of stable, less toxic complexes, methemoglobin induction, and sulfane sulfur supplementation for detoxification by endogenous rhodanese. Each antidote has advantages and disadvantages. For example, hydroxocobalamin is safer than the methemoglobin inducers in patients with smoke inhalation. Research for new, safer and more effective cyanide antidotes continues.

  10. [A case of Veratrum poisoning].

    PubMed

    Festa, M; Andreetto, B; Ballaris, M A; Panio, A; Piervittori, R

    1996-05-01

    A poisoning from a Veratrum album infusion mistaken for Gentiana lutea is described. Confusion between these two plants can easily occur because they are very similar, although flowers and disposition of leaves allow their botanic determinat: V. album leaves are alternate and flowers are white, while G. lutea leaves are opposite and flowers yellow. The poisoning involves gastrointestinal (pyrosis, vomiting) and cardiocirculatory systems (bradyarrhy-thmias, A-V dissociation, vasodilatation) Atropine is the drug of choice.

  11. Accidental poisoning in young children.

    PubMed Central

    Basavaraj, D S; Forster, D P

    1982-01-01

    Cases of accidental childhood poisoning admitted to hospital were compared with community controls and hospital controls matched for age and sex. The relative risks of factors in the cases compared with both the control groups were significant for roughness, aggressiveness, noisiness, and pica behaviour in the child, and for large families. Mothers' knowledge of the toxicity of common household products and drugs did not give significant risk differences between cases and controls. The majority of poisonings occurred during the summer months. PMID:7069353

  12. Cholinergic Crisis after Rodenticide Poisoning

    PubMed Central

    Waseem, Muhammad; Perry, Christopher; Bomann, Scott; Pai, Meena; Gernsheimer, Joel

    2010-01-01

    Rodenticides have historically been common agents in attempted suicides. As most rodenticides in the United States (U.S.) are superwarfarins, these ingestions are generally managed conservatively with close monitoring for coagulopathy, and if necessary, correction of any resulting coagulopathy. However, alternate forms of rodenticides are imported illegally into the U.S. and may be ingested either accidentally or in suicide attempts. We present an unusual case of poisoning by the illegally imported rodenticide, “Tres Pasitos.” The main ingredient of this rat poison is aldicarb, a potent carbamate pesticide that causes fulminant cholinergic crisis. This case is relevant and timely because carbamates and organophosphates are still used as insecticides and emergency physicians (EP) working in rural areas may have to evaluate and manage patients with these poisonings. As international travel and immigration have increased, so has the possibility of encountering patients who have ingested toxic substances from other countries. In addition, there has been increased concern about the possibility of acts of terrorism using chemical substances that cause cholinergic toxidromes.1,2 EPs must be able to recognize and manage these poisonings. This report describes the mechanism of action, clinical manifestations, laboratory evaluation and management of this type of poisoning. The pertinent medical literature on poisoning with aldicarb and similar substances is reviewed. PMID:21293782

  13. Channel modeling of light signals propagating through a battlefield environment: analysis of channel spatial, angular, and temporal dispersion.

    PubMed

    Wu, Binbin; Marchant, Brian; Kavehrad, Mohsen

    2007-09-01

    Free-space optical communication (FSOC) is used to transmit a modulated beam of light through the atmosphere for broadband applications. Fundamental limitations of FSOC arise from the environment through which light propagates. We address transmitted light signal dispersion (spatial, angular, and temporal dispersion) in FSOC that operates in the battlefield environment. Light signals (photons) transmitted through the battlefield environment will interact with particles of man-made smoke such as fog oil, along the propagation path. Photon-particle interaction causes dispersion of light signals, which has significant effects on signal attenuation and pulse spread. We show that physical properties of battlefield particles play important roles in determining dispersion of received light signals. The correlation between spatial and angular dispersion is investigated as well, which has significant effects on receiver design issues. Moreover, our research indicates that temporal dispersion (delay spread) and the received power strongly depend on the receiver aperture size, field of view (FOV), and the position of the receiver relative to the optical axis of the transmitter. The results describe only specific scenarios for given types of battlefield particles. Generalization of the results requires additional work. Based on properties of the correlation, a sensitive receiver with a small FOV is needed that can find the line-of-sight photons and work with them. PMID:17805385

  14. Sabatier Catalyst Poisoning Investigation

    NASA Technical Reports Server (NTRS)

    Nallette, Tim; Perry, Jay; Abney, Morgan; Knox, Jim; Goldblatt, Loel

    2013-01-01

    The Carbon Dioxide Reduction Assembly (CRA) on the International Space Station (ISS) has been operational since 2010. The CRA uses a Sabatier reactor to produce water and methane by reaction of the metabolic CO2 scrubbed from the cabin air and the hydrogen byproduct from the water electrolysis system used for metabolic oxygen generation. Incorporating the CRA into the overall air revitalization system has facilitated life support system loop closure on the ISS reducing resupply logistics and thereby enhancing longer term missions. The CRA utilizes CO2 which has been adsorbed in a 5A molecular sieve within the Carbon Dioxide Removal Assembly, CDRA. There is a potential of compounds with molecular dimensions similar to, or less than CO2 to also be adsorbed. In this fashion trace contaminants may be concentrated within the CDRA and subsequently desorbed with the CO2 to the CRA. Currently, there is no provision to remove contaminants prior to entering the Sabatier catalyst bed. The risk associated with this is potential catalyst degradation due to trace organic contaminants in the CRA carbon dioxide feed acting as catalyst poisons. To better understand this risk, United Technologies Aerospace System (UTAS) has teamed with MSFC to investigate the impact of various trace contaminants on the CRA catalyst performance at relative ISS cabin air concentrations and at about 200/400 times of ISS concentrations, representative of the potential concentrating effect of the CDRA molecular sieve. This paper summarizes our initial assessment results.

  15. Neurotoxic Shellfish Poisoning

    PubMed Central

    Watkins, Sharon M.; Reich, Andrew; Fleming, Lora E.; Hammond, Roberta

    2008-01-01

    Neurotoxic shellfish poisoning (NSP) is caused by consumption of molluscan shellfish contaminated with brevetoxins primarily produced by the dinoflagellate, Karenia brevis. Blooms of K. brevis, called Florida red tide, occur frequently along the Gulf of Mexico. Many shellfish beds in the US (and other nations) are routinely monitored for presence of K. brevis and other brevetoxin-producing organisms. As a result, few NSP cases are reported annually from the US. However, infrequent larger outbreaks do occur. Cases are usually associated with recreationally-harvested shellfish collected during or post red tide blooms. Brevetoxins are neurotoxins which activate voltage-sensitive sodium channels causing sodium influx and nerve membrane depolarization. No fatalities have been reported, but hospitalizations occur. NSP involves a cluster of gastrointestinal and neurological symptoms: nausea and vomiting, paresthesias of the mouth, lips and tongue as well as distal paresthesias, ataxia, slurred speech and dizziness. Neurological symptoms can progress to partial paralysis; respiratory distress has been recorded. Recent research has implicated new species of harmful algal bloom organisms which produce brevetoxins, identified additional marine species which accumulate brevetoxins, and has provided additional information on the toxicity and analysis of brevetoxins. A review of the known epidemiology and recommendations for improved NSP prevention are presented. PMID:19005578

  16. Fatal poisoning by vanadium.

    PubMed

    Boulassel, Brahim; Sadeg, Nouredine; Roussel, Olivier; Perrin, Martine; Belhadj-Tahar, Hafid

    2011-03-20

    We report here a fatal intoxication case involving ammonium vanadate. A 24-year-old woman was admitted to the Emergency Department for abdominal pain, nausea, vomiting, multiple daily diarrheas, hypoglycaemia (0.2g/L) and severe acute renal failure with glomerular filtration rate estimated at 21 ml/min. This patient had taken an undetermined amount of ammonium vanadate 12h after ingesting. She died next morning in the context of respiratory distress despite intensive care and oxygen therapy. The autopsy revealed widespread asphyxia syndrome and erosive gastritis. Determination of vanadium concentration in blood was carried out by means of mass spectrometer (ICP-MS) using rhodium ((103)Rh) as the internal standard. The vanadium concentration was 6.22 mg/L, corresponding to 6000 times higher than normal concentration in the general population. The latency and the brutality of clinical picture degradation seem to be in consideration of systemic poisoning by vanadium leading to inhibition of the cellular respiratory process.

  17. [Chronic ethylene glycol poisoning].

    PubMed

    Kaiser, W; Steinmauer, H G; Biesenbach, G; Janko, O; Zazgornik, J

    1993-04-30

    Over a six-week period a 60-year-old patient had several unexplained intoxication-like episodes. He finally had severe abdominal cramps with changes in the level of consciousness and oligoanuric renal failure (creatinine 4.7 mg/dl). The history, marked metabolic acidosis (pH 7.15, HCO3- 2.2 mmol/l, pCO2 6.6 mmHg) as well as raised anion residue (43 mmol/l) and the presence of oxalates in urine suggested poisoning by ethylene glycol contained in antifreeze liquid. Intensive haemodialysis adequately eliminated ethylene glycol and its toxic metabolites (glycol aldehyde, glycolic acid). Renal function returned within 10 days, although the concentrating power of the kidney remained impaired for several weeks because of interstitial nephritis. The intoxication had been caused by a defective heating-pipe system from which the antifreeze had leaked into the hot-water boiler (the patient had habitually prepared hot drinks by using water from the hot-water tap). Gas chromatography demonstrated an ethylene glycol concentration of 21 g per litre of water.

  18. Serial cholinesterase estimation in carbamate poisoning.

    PubMed

    Pinakini, K S; Kumar, T S Mohan

    2006-07-01

    Poisoning is one of the most important causes of morbidity and mortality in developing countries like India. Anticholinesterase compounds like organophosphates (OP) and carbamates account for the majority of these poisoning cases because of their easy availability and agricultural use. Carbamates are as popular as OPs as insecticides that often go undiagnosed. A fatal case of carbofuran poisoning is presented where serial cholinesterase estimation played a major role in the diagnosis of the same. The pertinent medical literature on carbofuran poisoning is reviewed. The establishment of poison information center in each state is needed for proper diagnosis and management of poisoning cases.

  19. In search of technological solutions to battlefield management of combat casualties

    NASA Astrophysics Data System (ADS)

    Ling, Geoffrey S. F.; Day, Keith; Rhee, Peter; Ecklund, James M.

    1999-07-01

    It is accepted that so long as men and women are sent into combat, some will be wounded or killed. In order to minimize those that are killed, efforts must be made to optimize medical treatment for those who are not fatally wounded. The nature of warfare is changing. The pattern of wounding is changing as well. However, what remains constant is the need to provide effective treatment as soon as possible. In war, it means acting at the level of the battlefield. To be effective demands new approaches to diagnosis and treatment. Novel diagnostic tools are needed to identify location of foreign bodies, determine extents of injury, monitor vital signs, and ascertain adequacy of resuscitation. Treatment devices that can provide hemostasis, support organ perfusion, stabilize limbs and neck and relieve a pneumothorax are lacking. Our young soldiers of tomorrow need solutions to their injuries today.

  20. A Highly Agile Ground Assessment Robot (HAGAR) for military battlefield and support missions

    SciTech Connect

    Klarer, P.

    1994-04-01

    A mobile robotic vehicle with potential for use in military field applications is described. Based on a Sandia design intended for use in exploration of the Lunar surface, the Highly Agile Ground Assessment Robot (HAGAR) is a four wheeled all-wheel-drive dual-body vehicle. A uniquely simple method of chassis articulation is employed which allows all four wheels to remain in contact with the ground, even while operating in very rough terrain and climbing over obstacles as large as a wheel diameter. Skid steering and modular construction are used to produce a simple, rugged, lightweight, highly agile mobility chassis with a reduction in the number of parts required when compared to conventional vehicle designs for military battlefield and support missions. The design configuration, mobility parameters, potential mission configurations, and performance of existing and proposed HAGAR prototypes are discussed.

  1. Battlefield ethics training: integrating ethical scenarios in high-intensity military field exercises

    PubMed Central

    Thompson, Megan M.; Jetly, Rakesh

    2014-01-01

    There is growing evidence that modern missions have added stresses and ethical complexities not seen in previous military operations and that there are links between battlefield stressors and ethical lapses. Military ethicists have concluded that the ethical challenges of modern missions are not well addressed by current military ethics educational programs. Integrating the extant research in the area, we propose that scenario-based operational ethics training in high-intensity military field training settings may be an important adjunct to traditional military ethics education and training. We make the case as to why this approach will enhance ethical operational preparation for soldiers, supporting their psychological well-being as well as mission effectiveness. PMID:25206947

  2. C1 Inhibitor Limits Organ Injury and Prolongs Survival in Swine Subjected to Battlefield Simulated Injury.

    PubMed

    Campbell, James C; Li, Yansong; van Amersfoort, Edwin; Relan, Anurag; Dubick, Michael; Sheppard, Forest; Pusateri, Anthony; Niemeyer, Debra; Tsokos, George C; Dalle Lucca, Jurandir J

    2016-09-01

    Complement system activation is recognized as a deleterious component of the mammalian physiological response to traumatic injury with severe hemorrhage (TH). Female Yorkshire swine were subjected to a simulated austere prehospital battlefield scenario. Each animal underwent controlled hemorrhage of 22 mL/kg at 100 mL/min rate for approximately 10 min followed by soft tissue injury, femur fracture, and spleen injury. Subsequent blood loss was uncontrolled. Twenty-eight minutes postinjury the animals were randomized into treatment or no treatment with recombinant human C1 esterase inhibitor (C1INH) (500 IU/kg, n = 11) and into receiving or not permissive hypotensive resuscitation (n = 14) with infusion of 45 mL/kg lactated Ringer's solution (2× blood lost). Observation and animal maintenance continued for 6 h at which time the animals had either expired or were euthanized. Heart, lung, and small intestine tissue samples were collected. Pharmacokinetic, hemodynamic, and metabolic parameters as well as survival time, plasma complement activity and tissue deposition, cytokine levels, and tissue injury were determined. We found that administration of C1INH protected tissues from damage, reduced the levels of inflammatory cytokines, and improved blood chemistry. Immunohistochemical analyses revealed that C1INH administration following TH markedly reduced complement activation and deposition in tissues. Importantly, C1INH administration prolonged survival of animals particularly in those which received resuscitation fluid infusion. Our data urge early administration of C1INH to limit organ damage and prolong survival of those injured in the battlefield. PMID:27405065

  3. Advanced Soldier Thermoelectric Power System for Power Generation from Battlefield Heat Sources

    SciTech Connect

    Hendricks, Terry J.; Hogan, Tim; Case, Eldon D.; Cauchy, Charles J.

    2010-09-01

    The U.S. military uses large amounts of fuel during deployments and battlefield operations. This project sought to develop a lightweight, small form-factor, soldier-portable advanced thermoelectric (TE) system prototype to recover and convert waste heat from various deployed military equipment (i.e., diesel generators/engines, incinerators, vehicles, and potentially mobile kitchens), with the ultimate purpose of producing power for soldier battery charging, advanced capacitor charging, and other battlefield power applications. The technical approach employed microchannel technology, a unique “power panel” approach to heat exchange/TE system integration, and newly-characterized LAST (lead-antimony-silver-telluride) and LASTT (lead-antimony-silver-tin-telluride) TE materials segmented with bismuth telluride TE materials in designing a segmented-element TE power module and system. This project researched never-before-addressed system integration challenges (thermal expansion, thermal diffusion, electrical interconnection, thermal and electrical interfaces) of designing thin “power panels” consisting of alternating layers of thin, microchannel heat exchangers (hot and cold) sandwiching thin, segmented-element TE power generators. The TE properties, structurally properties, and thermal fatigue behavior of LAST and LASTT materials were developed and characterized such that the first segmented-element TE modules using LAST / LASTT materials were fabricated and tested at hot-side temperatures = 400 °C and cold-side temperatures = 40 °C. LAST / LASTT materials were successfully segmented with bismuth telluride and electrically interconnected with diffusion barrier materials and copper strapping within the module electrical circuit. A TE system design was developed to produce 1.5-1.6 kW of electrical energy using these new TE modules from the exhaust waste heat of 60-kW Tactical Quiet Generators as demonstration vehicles.

  4. First far-infrared high resolution analysis of the ν6 band of phosgene 35Cl2CO and 35Cl37ClCO

    NASA Astrophysics Data System (ADS)

    Flaud, J.-M.; Tchana, F. Kwabia; Lafferty, W. J.; Manceron, L.; Ndao, M.

    2016-08-01

    A Fourier transform spectrum of phosgene (Cl2CO) has been recorded in the 22.5 μm spectral region at a resolution of 0.00102 cm-1 using a Bruker IFS125HR spectrometer coupled to synchrotron radiation leading to the observation of the ν6 vibrational bands of the two isotopologues 35Cl2CO and 35Cl37ClCO. The corresponding upper state ro-vibrational levels were fit using Watson-type Hamiltonians. In this way it was possible to reproduce the upper state ro-vibrational levels to within the experimental uncertainty i.e. ∼0.30 × 10-3 cm-1. Very accurate rotational and centrifugal distortion constants were derived from the fit together with the following band centers: ν0(ν6,35Cl2CO) = 443.172062(15) cm-1, ν0(ν6,35Cl37ClCO) = 440.534956(17) cm-1.

  5. Histamine poisoning (scombroid fish poisoning): an allergy-like intoxication.

    PubMed

    Taylor, S L; Stratton, J E; Nordlee, J A

    1989-01-01

    Histamine poisoning results from the consumption of foods, typically certain types of fish and cheeses, that contain unusually high levels of histamine. Spoiled fish of the families, Scombridae and Scomberesocidae (e.g. tuna, mackerel, bonito), are commonly implicated in incidents of histamine poisoning, which leads to the common usage of the term, "scombroid fish poisoning", to describe this illness. However, certain non-scombroid fish, most notably mahi-mahi, bluefish, and sardines, when spoiled are also commonly implicated in histamine poisoning. Also, on rare occasions, cheeses especially Swiss cheese, can be implicated in histamine poisoning. The symptoms of histamine poisoning generally resemble the symptoms encountered with IgE-mediated food allergies. The symptoms include nausea, vomiting, diarrhea, an oral burning sensation or peppery taste, hives, itching, red rash, and hypotension. The onset of the symptoms usually occurs within a few minutes after ingestion of the implicated food, and the duration of symptoms ranges from a few hours to 24 h. Antihistamines can be used effectively to treat this intoxication. Histamine is formed in foods by certain bacteria that are able to decarboxylate the amino acid, histidine. However, foods containing unusually high levels of histamine may not appear to be outwardly spoiled. Foods with histamine concentrations exceeding 50 mg per 100 g of food are generally considered to be hazardous. Histamine formation in fish can be prevented by proper handling and refrigerated storage while the control of histamine formation in cheese seems dependent on insuring that histamine-producing bacteria are not present in significant numbers in the raw milk.

  6. Management of carbon monoxide poisoning.

    PubMed

    Ilano, A L; Raffin, T A

    1990-01-01

    Carbon monoxide poisoning is a major cause of illness and death in the United States. Most cases result from exposure to the internal combustion engine and to stoves burning fossil fuels. Most cases of accidental exposure are preventable if proper precautions are taken; however, when cases arise, their presenting signs and symptoms are nonspecific and often lead to a misdiagnosis resembling a flu-like viral illness. As a result, the incidence of acute CO poisoning is underestimated. The effects of CO poisoning are due to tissue hypoxia, with the CNS and the heart being the most susceptible target organs due to their high oxygen needs. Prolonged hypoxia due to high CO levels may lead to cardiac arrhythmias or arrest (or both) and a variety of neurologic sequelae. Treatment is directed toward the relief of tissue hypoxia and the removal of CO from the body. Severity of poisoning can be divided into three levels based on CO levels in the blood. Administration of normobaric 100 percent oxygen is the therapy of choice for most cases, while hyperbaric oxygen therapy is reserved for severe poisonings.

  7. CDC Vital Signs: Alcohol Poisoning Deaths

    MedlinePlus

    ... Digital Press Kit Read the MMWR Science Clips Alcohol Poisoning Deaths A deadly consequence of binge drinking ... less binge drinking. Problem There are 2,200 alcohol poisoning deaths in the US each year. Alcohol ...

  8. "Suicide" as Seen in Poison Control Centers

    ERIC Educational Resources Information Center

    McIntire, Matilda S.; Angle, Carol R.

    1971-01-01

    Data on age and sex characteristics, intent and diagnosis of suicide, and toxicology are presented for 1,103 cases of poisoning (children ages 6-18 years) admitted to 50 poison control centers during 1 year. (KW)

  9. Lead Poisoning - Multiple Languages: MedlinePlus

    MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Lead Poisoning URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Lead Poisoning - Multiple Languages To use the sharing features on ...

  10. Paint, lacquer, and varnish remover poisoning

    MedlinePlus

    Paint remover poisoning ... Paint lacquer and varnish remover poisoning can cause symptoms in various parts of the body. AIRWAYS AND LUNGS Breathing difficulty (from inhalation) Throat swelling (may also cause ...

  11. Non-accidental salt poisoning.

    PubMed Central

    Meadow, R

    1993-01-01

    The clinical features of 12 children who incurred non-accidental salt poisoning are reported. The children usually presented to hospital in the first six months of life with unexplained hypernatraemia and associated illness. Most of the children suffered repetitive poisoning before detection. The perpetrator was believed to the mother for 10 children, the father for one, and either parent for one. Four children had serum sodium concentrations above 200 mmol/l. Seven children had incurred other fabricated illness, drug ingestion, physical abuse, or failure to thrive/neglect. Two children died; the other 10 remained healthy in alternative care. Features are described that should lead to earlier detection of salt poisoning; the importance of checking urine sodium excretion, whenever hypernatraemia occurs, is stressed. PMID:8503665

  12. Pesticide poisonings in Costa Rica.

    PubMed

    Wesseling, C; Castillo, L; Elinder, C G

    1993-08-01

    A descriptive epidemiologic study, conducted in Costa Rica, investigated the incidence of pesticide poisonings with special attention to agricultural workers and occupational exposure. Information from three national registers (occupational accident and disease reports, hospitalizations, and deaths) were used. During 1986, 1800 occupational accidents caused by pesticides were reported; between 1980 and 1986 altogether 3330 persons were hospitalized and 429 died. Cholinesterase inhibitors caused 71% of the reported occupational accidents, 63% of the hospitalizations, and 36% of the deaths. Paraquat caused 21% of the occupational accidents, 24% of the hospitalizations, and 60% of the deaths. Hospitalizations and deaths were 13 and 11 times, respectively, more frequent among agricultural workers than among the rest of the population. High-risk groups for occupational poisonings included agricultural workers aged 15-29 years, female workers, and banana plantation workers. The yearly incidence of symptomatic occupational pesticide poisonings among agricultural workers was estimated at 4.5%.

  13. Poisonous birds: A timely review.

    PubMed

    Ligabue-Braun, Rodrigo; Carlini, Célia Regina

    2015-06-01

    Until very recently, toxicity was not considered a trait observed in birds, but works published in the last two decades started to shed light on this subject. Poisonous birds are rare (or little studied), and comprise Pitohui and Ifrita birds from Papua New Guinea, the European quail, the Spoor-winged goose, the Hoopees, the North American Ruffed grouse, the Bronzewings, and the Red warbler. A hundred more species are considered unpalatable or malodorous to humans and other animals. The present review intends to present the current understanding of bird toxicity, possibly pointing to an ignored research field. Whenever possible, biochemical characteristics of these poisons and their effects on humans and other animals are discussed, along with historical aspects of poison discovery and evolutionary hypothesis regarding their function.

  14. Poisoning in the United States: 2012 emergency medicine report of the National Poison Data System.

    PubMed

    Dart, Richard C; Bronstein, Alvin C; Spyker, Daniel A; Cantilena, Louis R; Seifert, Steven A; Heard, Stuart E; Krenzelok, Edward P

    2015-04-01

    Deaths from drug overdose have become the leading cause of injury death in the United States, where the poison center system is available to provide real-time advice and collect data about a variety of poisonings. In 2012, emergency medical providers were confronted with new poisonings, such as bath salts (substituted cathinones) and Spice (synthetic cannabinoid drugs), as well as continued trends in established poisonings such as from prescription opioids. This article addresses current trends in opioid poisonings; new substances implicated in poisoning cases, including unit-dose laundry detergents, bath salts, Spice, and energy drinks; and the role of poison centers in public health emergencies such as the Fukushima radiation incident.

  15. 49 CFR 172.430 - POISON label.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON label. 172.430 Section 172.430... SECURITY PLANS Labeling § 172.430 POISON label. (a) Except for size and color, the POISON label must be as follows: EC02MR91.029 (b) In addition to complying with § 172.407, the background on the POISON label...

  16. 49 CFR 172.430 - POISON label.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false POISON label. 172.430 Section 172.430... SECURITY PLANS Labeling § 172.430 POISON label. (a) Except for size and color, the POISON label must be as follows: EC02MR91.029 (b) In addition to complying with § 172.407, the background on the POISON label...

  17. 49 CFR 172.430 - POISON label.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false POISON label. 172.430 Section 172.430... SECURITY PLANS Labeling § 172.430 POISON label. (a) Except for size and color, the POISON label must be as follows: EC02MR91.029 (b) In addition to complying with § 172.407, the background on the POISON label...

  18. 49 CFR 172.430 - POISON label.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false POISON label. 172.430 Section 172.430... SECURITY PLANS Labeling § 172.430 POISON label. (a) Except for size and color, the POISON label must be as follows: EC02MR91.029 (b) In addition to complying with § 172.407, the background on the POISON label...

  19. 49 CFR 172.430 - POISON label.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false POISON label. 172.430 Section 172.430... SECURITY PLANS Labeling § 172.430 POISON label. (a) Except for size and color, the POISON label must be as follows: EC02MR91.029 (b) In addition to complying with § 172.407, the background on the POISON label...

  20. Venomous bites, stings, and poisoning.

    PubMed

    Warrell, David A

    2012-06-01

    This article discusses the epidemiology, prevention, clinical features, first aid and medical treatment of venomous bites by snakes, lizards, and spiders; stings by fish, jellyfish, echinoderms, and insects; and poisoning by fish and molluscs, in all parts of the world. Of these envenoming and poisonings, snake bite causes the greatest burden of human suffering, killing 46,000 people each year in India alone and more than 100,000 worldwide and resulting in physical handicap in many survivors. Specific antidotes (antivenoms/antivenins) are available to treat envenoming by many of these taxa but supply and distribution is inadequate in many tropical developing countries.

  1. Captain Cook on poison fish.

    PubMed

    Doherty, Michael J

    2005-12-13

    On his second voyage of discovery, Captain James Cook charted much of the South Pacific. The journey was long, from 1772 to 1775. During the exploration, the geographic, ethnographic, and scientific variety provided no shortage of work for the accompanying naturalists, astronomers, navigators, and painters. Culinary discoveries included new species of fish, many of which were sketched, dressed, and ultimately eaten. The examined journals and correspondence document clinical poisonings after ingestion of two different species of fish. The clinical findings are described and likely represent ciguatera and tetrodotoxin poisonings. Mechanisms of these toxin's actions are discussed in light of more recent studies. PMID:16344524

  2. Plasma catecholamine activity in chronic lead poisoning

    SciTech Connect

    deCastro, F.J.

    1990-04-01

    Plasma catecholamines where measured in 15 children with chronic lead poisoning and 15 matched controls by radioimmunassay. The data suggest that plasma catecholamines (norepinephrine and epinphrine) were significantly elevated in chronic lead poisoning. Plasma catecholamine elevation may well be important in the clinical finding of hyperactivity and hypertension associated with chronic lead poisoning.

  3. Childhood Lead Poisoning: Blueprint for Prevention.

    ERIC Educational Resources Information Center

    Rochow, K. W. James; Rapuano, Maria

    Current programs to deal with childhood lead poisoning, the primary environmental disease of U.S. children, screen individual children, treat those with serious cases of lead poisoning, and subsequently return children to hazardous environments. This approach has led to repeated diagnoses of lead poisoning. This handbook is designed to convince…

  4. Helping Parents Prevent Lead Poisoning. ERIC Digest.

    ERIC Educational Resources Information Center

    Binns, Helen J.; Ricks, Omar Benton

    Children are at greater risk than adults for lead poisoning because children absorb lead more readily than adults, and a small amount of lead in children's bodies can do a great deal of harm. Some of the causes and effects of childhood lead poisoning and suggests some lead poisoning prevention strategies that parent educators can share with…

  5. 76 FR 9585 - Poison Control Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... HUMAN SERVICES Health Resources and Services Administration Poison Control Program AGENCY: Health... SUNY d.b.a. the Upstate New York Poison Control Center. HRSA will also transfer funds and duties from... Control Center. These transfers are necessary in order to maintain poison control services and...

  6. Lead Poisoning: A Need for Education.

    ERIC Educational Resources Information Center

    Lipnickey, Susan Cross

    1981-01-01

    Each year approximately 200 children die of lead poisoning. Especially vulnerable to the toxic effects of lead poisoning are the nervous system, kidneys, and the bones. Physiological effects of lead on the school-age child, screening processes, and roles of school personnel in dealing with suspected victims of lead poisoning are discussed. (JN)

  7. 49 CFR 172.554 - POISON placard.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false POISON placard. 172.554 Section 172.554... SECURITY PLANS Placarding § 172.554 POISON placard. (a) Except for size and color, the POISON placard must be as follows: EC02MR91.057 (b) In addition to complying with § 172.519, the background on the...

  8. 49 CFR 172.554 - POISON placard.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false POISON placard. 172.554 Section 172.554... SECURITY PLANS Placarding § 172.554 POISON placard. (a) Except for size and color, the POISON placard must be as follows: EC02MR91.057 (b) In addition to complying with § 172.519, the background on the...

  9. 49 CFR 172.554 - POISON placard.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON placard. 172.554 Section 172.554... SECURITY PLANS Placarding § 172.554 POISON placard. (a) Except for size and color, the POISON placard must be as follows: EC02MR91.057 (b) In addition to complying with § 172.519, the background on the...

  10. 49 CFR 172.554 - POISON placard.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false POISON placard. 172.554 Section 172.554... SECURITY PLANS Placarding § 172.554 POISON placard. (a) Except for size and color, the POISON placard must be as follows: EC02MR91.057 (b) In addition to complying with § 172.519, the background on the...

  11. 49 CFR 172.554 - POISON placard.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false POISON placard. 172.554 Section 172.554... SECURITY PLANS Placarding § 172.554 POISON placard. (a) Except for size and color, the POISON placard must be as follows: EC02MR91.057 (b) In addition to complying with § 172.519, the background on the...

  12. National Poison Prevention Week Promotional Materials.

    ERIC Educational Resources Information Center

    Poison Prevention Week Council, Washington, DC.

    This collection of materials for parents, early childhood workers, the elderly, and anyone in situations requiring safeguards against poisoning, spans the years 1993 and 1994 and is intended to promote National Poison Prevention Week. The materials included are: (1) the 31-page, illustrated report on National Poison Prevention Week for 1993,…

  13. Ground-penetrating radar and electromagnetic surveys at the Monroe Crossroads battlefield site, Fort Bragg, North Carolina

    USGS Publications Warehouse

    Kessler, Richard; Strain, R.E.; Marlowe, J. I.; Currin, K.B.

    1996-01-01

    A ground-penetrating radar survey was conducted at the Monroe Crossroads Battlefield site at Fort Bragg, North Carolina, to determine possible locations of subsurface archaeological features. An electromagnetic survey also was conducted at the site to verify and augment the ground-penetrating radar data. The surveys were conducted over a 67,200-square-foot grid with a grid point spacing of 20 feet. During the ground-penetrating radar survey, 87 subsurface anomalies were detected based on visual inspection of the field records. These anomalies were flagged in the field as they appeared on the ground-penetrating radar records and were located by a land survey. The electromagnetic survey produced two significant readings at ground-penetrating radar anomaly locations. The National Park Service excavated 44 of the 87 anomaly locations at the Civil War battlefield site. Four of these excavations produced significant archaeological features, including one at an abandoned well.

  14. Acute arsenical poisoning in Dunedin.

    PubMed

    Gillies, A J; Taylor, A J

    1979-05-23

    Four cases of acute poisoning with arsenic are described. Although no new approach to therapy is proposed it is suggested from the data of arsenic recovery from the dialysate of one of the patients studied, that peritoneal dialysis is unlikely to be satisfactory.

  15. Staphylococcal food poisoning and botulism

    PubMed Central

    Gilbert, R. J.

    1974-01-01

    Staphylococcal food poisoning and botulism are caused by the ingestion of food containing exotoxins. Outbreaks of both are still a problem in many countries. This paper attempts to summarize information relating to these illnesses, together with advice on how their incidence may be reduced, or better still prevented. PMID:4619651

  16. Lead poisoning by contaminated flour.

    PubMed

    Hershko, C; Eisenberg, A; Avni, A; Grauer, F; Acker, C; Hamdallah, M; Shahin, S; Moreb, J; Richter, E; Weissenberg, E

    1989-01-01

    Between October 1982 and June 1983, 43 patients were identified with symptomatic lead poisoning in three Arab villages of the Nablus district. Because of the clustering of clinical poisoning by household units, investigation was focussed on potential sources common to all members of the households. After excluding water, olive oil and a variety of foodstuff, lead in high concentrations was discovered in locally ground flour in all affected households. The source of poisoning was lead poured into the fissures between the metal housing and the driveshaft of the millstone. Significant lead contamination of freshly ground flour was demonstrated in 23% of the 146 community flour mills operating in West Bank villages. Since the completion of these studies, similar outbreaks of lead poisoning caused by contaminated flourmills have been identified in the Upper Galilee and in Spain. As the methods of milling in the Mediterranean area are similar, a coordinated international effort is needed in order to eliminate this health hazard from countries where similar community stone mills are still in use.

  17. [Arsenic poisoning: a special gastroenteritis...].

    PubMed

    Ganster, F; Kuteifan, K; Mootien, Y; Harry, P; Guiot, P

    2009-06-01

    Arsenic (As) intoxication is nowadays extremely rare. Two cases of acute and chronic As criminal poisoning leading to death of a couple of retired people, are reported. Clinical presentation was simulating a gastro-enteritidis with fast evolution to refractory shock. Toxicological analysis confirmed this diagnostic, with respectively blood As concentrations at 579 and 21 765 microg/l for our two patients.

  18. Acute arsenic poisoning diagnosed late.

    PubMed

    Shumy, Farzana; Anam, Ahmad Mursel; Kamruzzaman, A K M; Amin, Md Robed; Chowdhury, M A Jalil

    2016-04-01

    Acute arsenicosis, although having a 'historical' background, is not common in our times. This report describes a case of acute arsenic poisoning, missed initially due to its gastroenteritis-like presentation, but suspected and confirmed much later, when the patient sought medical help for delayed complications after about 2 months.

  19. Lead Poisoning in Jewellery Enamellers

    PubMed Central

    Fothergill, R.; Kipling, M. D.; Weber, A. B.

    1967-01-01

    Lead poisoning in jewellery enamellers in Birmingham has been described both at the beginning of this century and again in recent years. The condition arises from the habit of some workers of placing the enamel applicator in the mouth. The history of the hazard is reviewed and an investigation described. PMID:6073093

  20. [Poisonous animals registration in Poland].

    PubMed

    Mitrus, Małgorzata; Szkolnicka, Beata; Satora, Leszek; Morawska, Jowanka

    2005-01-01

    The Act on Nature Conservation of 16.04.2004 (Official Journal, 2004, No 92, item 880) imposes on private individuals the duty to register some animals. The data collected by Kraków municipal authorities and delivered to the Poison Information Centre (Colleglum Medicum, Jagiellonian University) indicate that there are following species in private hands in the city and its surroundings: 11 individuals of Naja naja, 2--Hydrodynates gigas and 55-- Dendrobates spp. According to these information the employees of the PIC elaborated the advice on the treatment of specific animals' poisoning. In the period May 2003 - May 2004 (before the above Act came into force) there were 143 individuals from Brachypelma genus and 3 scorpions (Pandinus imperator) registered in Krakow. These species produce venoms which take local effect. According to art. 64 (1) of the above Act it is compulsory to register amphibians, reptiles, birds and mammals. However, it would be desirable to introduce the duty to register also dangerous species of invertebrates and fishes. It would provide the complete list of poisonous animals kept in private hands. Thus, it would be possible to estimate any possible threats and to elaborate adequate treatment in case of specific animals' poisoning.

  1. [Poisonous animals registration in Poland].

    PubMed

    Mitrus, Małgorzata; Szkolnicka, Beata; Satora, Leszek; Morawska, Jowanka

    2005-01-01

    The Act on Nature Conservation of 16.04.2004 (Official Journal, 2004, No 92, item 880) imposes on private individuals the duty to register some animals. The data collected by Kraków municipal authorities and delivered to the Poison Information Centre (Colleglum Medicum, Jagiellonian University) indicate that there are following species in private hands in the city and its surroundings: 11 individuals of Naja naja, 2--Hydrodynates gigas and 55-- Dendrobates spp. According to these information the employees of the PIC elaborated the advice on the treatment of specific animals' poisoning. In the period May 2003 - May 2004 (before the above Act came into force) there were 143 individuals from Brachypelma genus and 3 scorpions (Pandinus imperator) registered in Krakow. These species produce venoms which take local effect. According to art. 64 (1) of the above Act it is compulsory to register amphibians, reptiles, birds and mammals. However, it would be desirable to introduce the duty to register also dangerous species of invertebrates and fishes. It would provide the complete list of poisonous animals kept in private hands. Thus, it would be possible to estimate any possible threats and to elaborate adequate treatment in case of specific animals' poisoning. PMID:16225138

  2. Acute arsenic poisoning diagnosed late.

    PubMed

    Shumy, Farzana; Anam, Ahmad Mursel; Kamruzzaman, A K M; Amin, Md Robed; Chowdhury, M A Jalil

    2016-04-01

    Acute arsenicosis, although having a 'historical' background, is not common in our times. This report describes a case of acute arsenic poisoning, missed initially due to its gastroenteritis-like presentation, but suspected and confirmed much later, when the patient sought medical help for delayed complications after about 2 months. PMID:26508422

  3. Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout.

    PubMed

    Yashio, Keiji; Katayama, Yumiko; Takashima, Tadayuki; Ishiguro, Naoki; Doi, Hisashi; Suzuki, Masaaki; Wada, Yasuhiro; Tamai, Ikumi; Watanabe, Yasuyoshi

    2012-01-01

    The synthesis and in vivo evaluation of (11)C -labeled uric acid ([(11)C]1), a potential imaging agent for the diagnosis of urate-related life-style diseases, was performed using positron emission tomography (PET) image analysis. First, the synthesis of [(11)C]1 was achieved by reacting 5,6-diaminouracil (2) with (11)C-labeled phosgene ([(11)C]COCl(2)). The radiochemical yield of [(11)C]1 was 37±7% (decay-corrected based on [(11)C]COCl(2)) with specific radioactivities of 96-152GBq/μmol at the end of synthesis (n=6). The average time of radiosynthesis from the end of bombardment, including formulation, was about 30min with >98% radiochemical purity. Second, the synthetic approach to [(11)C]1 was optimized using 5,6-diaminouracil sulfate (3) with [(11)C]COCl(2) in the presence of 1,8-bis(dimethylamino)naphthalene. [(11)C]1 was synthesized in 36±6% radiochemical yield, 89-142GBq/μmol of specific radioactivities, and 98% radiochemical purity by this method (n=5). This allowed the synthesis of [(11)C]1 to be carried out repeatedly and the radiochemical yield, specific radioactivities, average time of synthesis, and radiochemical purity of [(11)C]1 were similar to those obtained using 2. PET studies in rats showed large differences in the accumulation of radioligand in the limbs under normal and hyperuricemic conditions. Thus, an efficient and convenient automated synthesis of [(11)C]1 has been developed, and preliminary PET evaluation of [(11)C]1 confirmed the increased accumulation of radioactivity in the limbs of a rat model of hyperuricemia.

  4. Choice of poison for intentional self-poisoning in rural Sri Lanka

    PubMed Central

    Eddleston, Michael; Karunaratne, Ayanthi; Weerakoon, Manjula; Kumarasinghe, Subashini; Rajapakshe, Manjula; Sheriff, MH Rezvi; Buckley, Nick A; Gunnell, David

    2007-01-01

    Background Although intentional self-poisoning is a major public health problem in rural parts of the Asia-Pacific region, relatively little is known of its epidemiology. We aimed to determine why Sri Lankan self-poisoning patients choose particular poisons, and whether acts of self-harm with highly dangerous poisons were associated with more premeditation and effort. Methods We interviewed 268 self-poisoning patients presenting to two district general hospitals in rural Sri Lanka. Results 85% of patients cited easy availability as the basis for their choice of poison. There was little premeditation: more than 50% ingested the poison less than 30 minutes after deciding to self-harm. Patients had little knowledge about treatment options or lethality of the poison chosen. We found no difference in reasons for choice of poison between people ingesting different poisons, despite marked differences in toxicity, and between people who died and those who survived. Conclusions Poisons were chosen on the basis of availability, often at short notice. There was no evidence that people using highly toxic poisons made a more serious or premeditated attempt. Restrictions on availability of highly toxic poisons in rural communities must be considered in strategies to reduce the number of intentional self-poisoning deaths in the Asia Pacific region. PMID:16749546

  5. A floral survey of cliff habitats along Bull Run at Manassas National Battlefield Park, Virginia, 2014

    USGS Publications Warehouse

    Stroh, Esther D.; Struckhoff, Matthew A.; Grabner, Keith W.

    2015-08-06

    Isolated patches of native vegetation in human-modified landscapes are important reservoirs of biological diversity because they may be the only places in which rare or native species can persist. Manassas National Battlefield Park, Virginia, is an island embedded in a matrix of intensively modified lands; it is becoming increasingly isolated due to growth of the greater Washington, D.C. area. A series of cliffs along Bull Run support an eastern white pine community disjunct from its more typical range in the Appalachian Mountains. Cliffs frequently support vegetation communities that differ from surrounding habitat. In this ecological context, the cliffs along Bull Run are islands of specialized habitat within an island of natural and semi-natural communities (the park), surrounded by a human-dominated landscape. A floral survey of these cliffs was a top priority identified by the National Park Service National Capital Region via the National Resource Preservation Program; in 2014, we completed a floral survey of 11 cliffs in the park. We recorded 282 species in 194 genera and 83 families, including 23 newly documented species for the park.

  6. Battlefield acupuncture: Opening the door for acupuncture in Department of Defense/Veteran's Administration health care.

    PubMed

    Walker, Patricia Hinton; Pock, Arnyce; Ling, Catherine G; Kwon, Kyung Nancy; Vaughan, Megan

    2016-01-01

    Battlefield acupuncture is a unique auricular acupuncture procedure which is being used in a number of military medical facilities throughout the Department of Defense (DoD). It has been used with anecdotal published positive impact with warriors experiencing polytrauma, post-traumatic stress disorder, and traumatic brain injury. It has also been effectively used to treat warriors with muscle and back pain from carrying heavy combat equipment in austere environments. This article highlights the history within the DoD related to the need for nonpharmacologic/opioid pain management across the continuum of care from combat situations, during evacuation, and throughout recovery and rehabilitation. The article describes the history of auricular acupuncture and details implementation procedures. Training is necessary and partially funded through DoD and Veteran's Administration (VA) internal Joint Incentive Funds grants between the DoD and the VA for multidisciplinary teams as part of a larger initiative related to the recommendations from the DoD Army Surgeon General's Pain Management Task Force. Finally, Uniformed Services University of the Health Sciences School of Medicine and Graduate School of Nursing faculty members present how this interdisciplinary training is currently being integrated into both schools for physicians and advanced practice nurses at the Uniformed Services University of the Health Sciences. Current and future research challenges and progress related to the use of acupuncture are also presented.

  7. Battlefield acupuncture: Opening the door for acupuncture in Department of Defense/Veteran's Administration health care.

    PubMed

    Walker, Patricia Hinton; Pock, Arnyce; Ling, Catherine G; Kwon, Kyung Nancy; Vaughan, Megan

    2016-01-01

    Battlefield acupuncture is a unique auricular acupuncture procedure which is being used in a number of military medical facilities throughout the Department of Defense (DoD). It has been used with anecdotal published positive impact with warriors experiencing polytrauma, post-traumatic stress disorder, and traumatic brain injury. It has also been effectively used to treat warriors with muscle and back pain from carrying heavy combat equipment in austere environments. This article highlights the history within the DoD related to the need for nonpharmacologic/opioid pain management across the continuum of care from combat situations, during evacuation, and throughout recovery and rehabilitation. The article describes the history of auricular acupuncture and details implementation procedures. Training is necessary and partially funded through DoD and Veteran's Administration (VA) internal Joint Incentive Funds grants between the DoD and the VA for multidisciplinary teams as part of a larger initiative related to the recommendations from the DoD Army Surgeon General's Pain Management Task Force. Finally, Uniformed Services University of the Health Sciences School of Medicine and Graduate School of Nursing faculty members present how this interdisciplinary training is currently being integrated into both schools for physicians and advanced practice nurses at the Uniformed Services University of the Health Sciences. Current and future research challenges and progress related to the use of acupuncture are also presented. PMID:27601311

  8. Evaluation of the US Army DT-236 battlefield personnel dosimetry system

    SciTech Connect

    Swaja, R.E.; Oyan, R.; Sims, C.S.; Dooley, M.A.

    1986-06-01

    Performance characteristics of the US Army DT-236 battlefield personnel dosimetry system were evaluated using the Health Physics Research Reactor at Oak Ridge National Laboratory. The DT-236 dosimeter is designed to measure total (neutron plus gamma) radiation dose using a radiophotoluminescent (RPL) detector for gamma rays and a silicon diode for fast neutrons. Areas considered in this evaluation included preirradiation dose indication; accuracy and precision of total, gamma, and neutron dose measurements; fading; angular response; temperature dependence; and relative dosimeter response in air and on various body locations. Experimental results for a variety of radiation fields and dose levels indicate that the existing system overestimates total, neutron, and gamma radiation doses in air by about 20 to 60% relative to reference values. Associated measurement precisions were about +-5% of the means for doses above approximately 0.5 Gy. Fading characteristics, angular dependence, and temperature dependence of the RPL and diode systems were consistent with results expected based on detector characteristics and previous performance studies. Recommendations to improve existing reader performance and measurement accuracy are also presented.

  9. A floral survey of cliff habitats along Bull Run at Manassas National Battlefield Park, Virginia, 2014

    USGS Publications Warehouse

    Stroh, Esther D.; Struckhoff, Matthew A.; Grabner, Keith W.

    2015-01-01

    Isolated patches of native vegetation in human-modified landscapes are important reservoirs of biological diversity because they may be the only places in which rare or native species can persist. Manassas National Battlefield Park, Virginia, is an island embedded in a matrix of intensively modified lands; it is becoming increasingly isolated due to growth of the greater Washington, D.C. area. A series of cliffs along Bull Run support an eastern white pine community disjunct from its more typical range in the Appalachian Mountains. Cliffs frequently support vegetation communities that differ from surrounding habitat. In this ecological context, the cliffs along Bull Run are islands of specialized habitat within an island of natural and semi-natural communities (the park), surrounded by a human-dominated landscape. A floral survey of these cliffs was a top priority identified by the National Park Service National Capital Region via the National Resource Preservation Program; in 2014, we completed a floral survey of 11 cliffs in the park. We recorded 282 species in 194 genera and 83 families, including 23 newly documented species for the park.

  10. Datura stramonium poisoning in children.

    PubMed

    Adegoke, S A; Alo, L A

    2013-01-01

    Although substance abuse is fairly common among adolescents, poisoning from Datura stramonium (a broadleaf annual erect herb with spine-covered seed capsule) is uncommon in children and has not been reported in our locality. We present the case of two children admitted at the Children Emergency Room of a teaching hospital following ingestion of extract of Datura stramonium. They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome. A high index of suspicion and early management of poison in children is imperative if a favorable outcome is expected. Early presentation and the presence of an eyewitness contributed to the very good outcome in these index cases. In this report, we discussed the symptomatology and management of Datura toxicity in children. PMID:23377485

  11. Malignant hyperthermia in endosulfan poisoning.

    PubMed

    Jain, Gaurav; Singh, Dinesh K; Yadav, Ghanshyam

    2012-01-01

    We are reporting a case of endosulfan poisoning, admitted in a state of altered consciousness, vomiting, and seizure. The diagnosis was based on history, physical examination and positive reports from toxicological screening. After 8 hrs of admission, a sudden rise in EtCO(2), respiratory rate, heart rate, blood pressure, and body temperature was noted. Masseter spasm was there and patient's elbow/knees could not be bent upon manipulation. Caffeine halothane contraction test later confirmed it to be malignant hyperthermia (MH). We suggest that if there is a sudden rise in body temperature, stiffness in limbs or massater spasm in a case of endosulfan poisoning, the diagnosis of MH should be considered as one possibility when etiology is not certain. PMID:22736908

  12. Fatal poisonings in Trabzon (Turkey).

    PubMed

    Birincioglu, Ismail; Karadeniz, Hulya; Teke, Hacer Yasar

    2011-05-01

    The aim of this study was to present the characteristics of medicolegal autopsies of fatal poisonings in Trabzon (Turkey), performed from 1998 to 2008, to contribute to the available data on this topic. A retrospective study of the forensic records and the toxicological data of all autopsies performed over that period revealed that 285 cases (6.34%) of the 4492 total autopsies performed were attributed to fatal poisoning. Major toxic substances were classified in five categories as follows: carbon monoxide (CO), insecticides, prescription medications, narcotic drugs, and alcohol (methyl and ethyl). CO was the most frequent cause of death (63.2%), followed by insecticides (17.2%), prescription medications and narcotic drugs (9.8%), alcohol (7.7%), and others (mushroom, rodenticide, and botulism) (2.1%). Ages of the patients ranged from 1 to 86 years (21.55 ± 36.56). PMID:21447071

  13. Congenital PCB poisoning: a reevaluation

    SciTech Connect

    Miller, R.W.

    1985-05-01

    A review of the literature reveals a need to clarify the pathologic physiology of congenital polychlorinated biphenyl (PCB) poisoning, which is characterized by intrauterine growth retardation, brown staining of the skin and mucous membranes as in Addison's disease, natal teeth, widely open fontanelles and sagittal suture and apparent overgrowth of the gingiva. The skull abnormalities may represent irregular calcification, with natal teeth appearing because the bone of the mandible is penetrated more easily than usual. Some fetuses were poisoned at the time the mothers ingested the oil; others were affected in the subsequent years from residual contamination in the mothers' bodies. The misadventure in Japan was repeated in Taiwan in 1979. The seven congenital cases in Taiwan reported thus far seem to differ from those in Japan. In Taiwan the noses were somewhat black, two of the infants did not have low birth weight and the osseous abnormalities of the skull and gingival hyperplasia were not observed. Systematic followup studies should be made in Taiwan of the children born within 2 years of maternal poisoning with PCBs. Special attention should be given to age at first dentition and skull-X-rays for spotty calcification, among other measures of physical, neurologic and intellectual development.

  14. Dermoscopy of black-spot poison ivy.

    PubMed

    Rader, Ryan K; Mu, Ruipu; Shi, Honglan; Stoecker, William V; Hinton, Kristen A

    2012-10-01

    Black-spot poison ivy is an uncommon presentation of poison ivy (Toxicodendron) allergic contact dermatitis. A 78-year-old sought evaluation of a black spot present on her right hand amid pruritic vesicles. The presentation of a black spot on the skin in a clinical context suggesting poison ivy is indicative of black-spot poison ivy. Dermoscopy revealed a jagged, centrally homogeneous, dark brown lesion with a red rim. A skin sample was obtained and compared against a poison ivy standard using ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS). This finding confirmed the presence of multiple urushiol congeners in the skin sample. Black-spot poison ivy may be added to the list of diagnoses that show a specific dermoscopic pattern.

  15. Metabolic complications of organophosphate and carbamate poisoning.

    PubMed

    Saadeh, A M

    2001-07-01

    The clinical manifestations of acute organophosphate (OP) and carbamate poisoning have already been well described. Most of these reports were on the cardiac, neurologic, respiratory and other clinical complications of these compounds. However, very little attention has been given to the metabolic aspects of this problem, particularly those accompanying carbamate poisoning. This paper describes the metabolic complications seen in 84 adult patients after acute poisoning with these compounds.

  16. Nephropathy in Chronic Lead Poisoning

    PubMed Central

    Lilis, Ruth; Gavrilescu, N.; Nestorescu, B.; Dumitriu, C.; Roventa, Ana

    1968-01-01

    This paper presents a study of renal function in 102 patients with lead poisoning admitted to the Occupational Diseases Clinic in Bucharest during the past 10 years; nearly half the patients had no history of lead colic. Every possible cause of renal damage, other than lead, was excluded by a careful differential diagnosis. Renal function was investigated by repeated determinations of blood urea, creatinine and uric acid, urea clearance, and endogenous creatinine clearance tests. Significant decreases of the clearance values (less than 50 ml./min. urea clearance and less than 80 ml./min. creatinine clearance), persistent high blood urea (more than 50 mg./100 ml.), and high blood creatinine (more than 1·2 mg./100 ml.) were found in a significant number of cases. These signs of impaired renal function were more frequent in the group of patients with chronic lead poisoning who had had several episodes of colic and an occupational exposure of more than 10 years. A high blood pressure was also found more frequently in this group of patients. Undercompensated and decompensated renal failure was found in 17 patients, most of whom had been exposed to lead for more than 10 years and had a history of several attacks of colic. Arterial hypertension accompanied the chronic renal failure in 13 patients, the renal impairment generally preceding the rise in blood pressure by several years. The duration of occupational lead exposure, the high absorption in the past, and the long period of observation of these patients, most of whom were repeatedly hospitalized, may explain the relatively high incidence (17 cases) of nephropathy with chronic renal failure in the present group. Impairment of urea clearance seems to be the earliest sign, at a time when the creatinine clearance is still normal. As the duration of exposure lengthens and the patient is subjected to active episodes of poisoning the creatinine clearance also deteriorates. Persistent urea retention and high creatininaemia

  17. Hemlock (Conium Maculatum) Poisoning In A Child.

    PubMed

    Konca, Capan; Kahramaner, Zelal; Bosnak, Mehmet; Kocamaz, Halil

    2014-03-01

    Poison hemlock (Conium maculatum) is a plant that is poisonous for humans and animals. Accidental ingestion of the plant may result in central nervous system depression, respiratory failure, acute rhabdomyolysis, acute renal failure and even death. The main treatment of hemlock poisoning is supportive care. The case of a 6-year-old girl who was admitted to the emergency department with complaints of burning sensation in mouth, hypersalivation, tremor in hands and ataxia after ingestion of poison hemlock is presented here with clinical and laboratory features. In this case, we aim to report that accidental ingestion of plants resembling vegetables that are consumed daily can lead to serious complications and even death.

  18. Profile of poisoning admissions in Malaysia.

    PubMed

    Rajasuriar, R; Awang, R; Hashim, S B H; Rahmat, H R B H

    2007-02-01

    We retrospectively reviewed poisoning admissions to all government health facilities from 1999 to 2001, in an effort to expand our current knowledge on poisoning in Malaysia to a level that better reflects a nationwide burden. There were 21 714 admissions reported with 779 deaths. The case-fatality rate was 35.88/1000 admissions. The majority of admissions (89.7%) and deaths (98.9%) occurred in adults. Some 55.1% of all admissions were female, mostly involving pharmaceutical agents. Male poisoning admissions were more often due to chemical substances. The prevalence of poisoning and death was highest among Indians compared to all other races in Malaysia. Overall, the majority of poisoning admissions were due to pharmaceutical agents, with agents classified as non-opioid analgesics, anti-pyretics and anti-rheumatics the most common. Pesticides accounted for the largest number of fatalities. It was also the commonest substance reported in cases of intentional self-harm. Most cases of poisoning admissions occurred due to accidental exposure (47%), followed by cases of intentional self-harm (20.7%). Overall, this study has managed to contribute substantial additional information regarding the epidemiology of poisoning in Malaysia, highlighting important issues, such as the rampant poisonings involving pesticides and analgesics, as well as the high prevalence of poisoning among Indians in Malaysia.

  19. Neural Mechanisms of Inhibitory Response in a Battlefield Scenario: A Simultaneous fMRI-EEG Study

    PubMed Central

    Ko, Li-Wei; Shih, Yi-Cheng; Chikara, Rupesh Kumar; Chuang, Ya-Ting; Chang, Erik C.

    2016-01-01

    The stop-signal paradigm has been widely adopted as a way to parametrically quantify the response inhibition process. To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: one uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. The BFS created a threatening environment and allowed the evaluation of how participants’ inhibitory control manifest in this realistic stop-signal task. In order to investigate the participants’ brain activities with both high spatial and temporal resolution, simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings were acquired. The results demonstrated that both scenarios induced increased activity in the right inferior frontal gyrus (rIFG) and presupplementary motor area (preSMA), which have been linked to response inhibition. Notably, in right temporoparietal junction (rTPJ) we found both higher blood-oxygen-level dependent (BOLD) activation and synchronization of theta-alpha activities (4–12 Hz) in the BFS than in the traditional scenario after the stop signal. The higher activation of rTPJ in the BFS may be related to morality judgments or attentional reorienting. These results provided new insights into the complex brain networks involved in inhibitory control within naturalistic environments. PMID:27199708

  20. Neural Mechanisms of Inhibitory Response in a Battlefield Scenario: A Simultaneous fMRI-EEG Study.

    PubMed

    Ko, Li-Wei; Shih, Yi-Cheng; Chikara, Rupesh Kumar; Chuang, Ya-Ting; Chang, Erik C

    2016-01-01

    The stop-signal paradigm has been widely adopted as a way to parametrically quantify the response inhibition process. To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: one uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. The BFS created a threatening environment and allowed the evaluation of how participants' inhibitory control manifest in this realistic stop-signal task. In order to investigate the participants' brain activities with both high spatial and temporal resolution, simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings were acquired. The results demonstrated that both scenarios induced increased activity in the right inferior frontal gyrus (rIFG) and presupplementary motor area (preSMA), which have been linked to response inhibition. Notably, in right temporoparietal junction (rTPJ) we found both higher blood-oxygen-level dependent (BOLD) activation and synchronization of theta-alpha activities (4-12 Hz) in the BFS than in the traditional scenario after the stop signal. The higher activation of rTPJ in the BFS may be related to morality judgments or attentional reorienting. These results provided new insights into the complex brain networks involved in inhibitory control within naturalistic environments.

  1. Telemedicine and mHealth odyssey: a journey from the battlefield to academia

    NASA Astrophysics Data System (ADS)

    Poropatich, Ronald; Presson, Nora; Gilbert, Gary

    2016-05-01

    Since 1992, military medicine has considered the relevance, sustainability, and promise of telemedicine in the context of its mission and obligations for service members at home and in war zones. The US Army telemedicine program covers 22 time zones and generates over 5000 tele-consults per month for over 20 medical specialties. More recently the advances in mobile computing and increased adoption of the Smartphone with evolving capabilities for imaging and body-worn sensor integration has emerged in the field called mobile health, or mHealth. This presentation highlights the first 10 years of the U.S. Army mHealth program and includes how similar technologies have translated to wide-scale civilian health care implementation, including a relevant project for Veterans at the University of Pittsburgh. Examples include the successful US Army "mCare" program developed to augment soldier rehabilitation management with USbased geographically dispersed providers that utilizes secure mobile messaging and the soldier's own cell phone. Additional research interests will describe the use of smartphones on the battlefield enabling capture of operational medical data to improve casualty evacuation and outcome. A DoD-funded traumatic brain injury research project developed for Veterans at the University of Pittsburgh includes a mobile health application that demonstrates the effectiveness of communicating with patients through their personal mobile devices with care managers. Preliminary data for all the projects presented are encouraging for adoption and utilization of a mobile telemedicine platform to meet the complex needs of casualties injured or recovering from a broad range of injuries in unique geographic settings.

  2. Neural Mechanisms of Inhibitory Response in a Battlefield Scenario: A Simultaneous fMRI-EEG Study.

    PubMed

    Ko, Li-Wei; Shih, Yi-Cheng; Chikara, Rupesh Kumar; Chuang, Ya-Ting; Chang, Erik C

    2016-01-01

    The stop-signal paradigm has been widely adopted as a way to parametrically quantify the response inhibition process. To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: one uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. The BFS created a threatening environment and allowed the evaluation of how participants' inhibitory control manifest in this realistic stop-signal task. In order to investigate the participants' brain activities with both high spatial and temporal resolution, simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings were acquired. The results demonstrated that both scenarios induced increased activity in the right inferior frontal gyrus (rIFG) and presupplementary motor area (preSMA), which have been linked to response inhibition. Notably, in right temporoparietal junction (rTPJ) we found both higher blood-oxygen-level dependent (BOLD) activation and synchronization of theta-alpha activities (4-12 Hz) in the BFS than in the traditional scenario after the stop signal. The higher activation of rTPJ in the BFS may be related to morality judgments or attentional reorienting. These results provided new insights into the complex brain networks involved in inhibitory control within naturalistic environments. PMID:27199708

  3. QuickStrike ASOC Battlefield Simulation: Preparing the War Fighter to Win

    NASA Technical Reports Server (NTRS)

    Jones, Richard L.

    2010-01-01

    The QuickStrike ASOC (Air Support Operations Center) Battlefield Simulation fills a crucial gap in USAF and United Kingdom Close Air Support (CAS) and airspace manager training. The system now provides six squadrons with the capability to conduct total-mission training events whenever the personnel and time are available. When the 111th ASOC returned from their first deployment to Afghanistan they realized the training available prior to deployment was inadequate. They sought an organic training capability focused on the ASOC mission that was low cost, simple to use, adaptable, and available now. Using a commercial off-the-shelf simulation, they developed a complete training system by adapting the simulation to their training needs. Through more than two years of spiral development, incorporating lessons learned, the system has matured, and can now realistically replicate the Tactical Operations Center (TOC) in Kabul, Afghanistan, the TOC supporting the mission in Iraq, or can expand to support a major conflict scenario. The training system provides a collaborative workspace for the training audience and exercise control group via integrated software and workstations that can easily adapt to new mission reqUirements and TOC configurations. The system continues to mature. Based on inputs from the war fighter, new capabilities have been incorporated to add realism and simplify the scenario development process. The QuickStrike simulation can now import TBMCS Air Tasking Order air mission data and can provide air and ground tracks to a common operating picture; presented through either C2PC or JADOCS. This oranic capability to practice team processes and tasks and to conduct mission rehearsals proved its value in the 111 h ASOS's next deployment. The ease of scenario development and the simple to learn and intuitive gamelike interface enables the squadrons to develop and share scenarios incorporating lessons learned from every deployment. These war fighters have now

  4. Raman spectra and cross sections of ammonia, chlorine, hydrogen sulfide, phosgene, and sulfur dioxide toxic gases in the fingerprint region 400-1400 cm-1

    NASA Astrophysics Data System (ADS)

    Aggarwal, R. L.; Farrar, L. W.; Di Cecca, S.; Jeys, T. H.

    2016-02-01

    Raman spectra of ammonia (NH3), chlorine (Cl2), hydrogen sulfide (H2S), phosgene (COCl2), and sulfur dioxide (SO2) toxic gases have been measured in the fingerprint region 400-1400 cm-1. A relatively compact (<2'x2'x2'), sensitive, 532 nm 10 W CW Raman system with double-pass laser and double-sided collection was used for these measurements. Two Raman modes are observed at 934 and 967 cm-1 in NH3. Three Raman modes are observed in Cl2 at 554, 547, and 539 cm-1, which are due to the 35/35 35/37, and 37/37 Cl isotopes, respectively. Raman modes are observed at 870, 570, and 1151 cm-1 in H2S, COCl2, and SO2, respectively. Values of 3.68 ± 0.26x10-32 cm2/sr (3.68 ± 0.26x10-36 m2/sr), 1.37 ± 0.10x10-30 cm2/sr (1.37 ± 0.10x10-34 m2/sr), 3.25 ± 0.23x10-31 cm2/sr (3.25 ± 0.23x10-35 m2/sr), 1.63 ± 0.14x10-30 cm2/sr (1.63 ± 0.14x10-34 m2/sr), and 3.08 ± 0.22x10-30 cm2/sr (and 3.08 ± 0.22x10-34 m2/sr) were determined for the differential Raman cross section of the 967 cm-1 mode of NH3, sum of the 554, 547, and 539 cm-1 modes of Cl2, 870 cm-1 mode of H2S, 570 cm-1 mode of COCl2, and 1151 cm-1 mode of SO2, respectively, using the differential Raman cross section of 3.56 ± 0.14x10-31 cm2/sr (3.56 ± 0.14x10-35 m2/sr) for the 1285 cm-1 mode of CO2 as the reference.

  5. [Hydrofluoric acid poisoning: case report].

    PubMed

    Cortina, Tatiana Judith; Ferrero, Hilario Andrés

    2013-01-01

    Hydrofluoric acid is a highly dangerous substance with industrial and domestically appliances. Clinical manifestations of poisoning depend on exposure mechanism, acid concentration and exposed tissue penetrability. Gastrointestinal tract symptoms do not correlate with injury severity. Patients with history of hydrofluoric acid ingestion should undergo an endoscopy of the upper gastrointestinal tract. Intoxication requires immediate intervention because systemic toxicity can take place. We present a 5 year old girl who accidentally swallowed 5 ml of 20% hydrofluoric acid. We performed gastrointestinal tract endoscopy post ingestion, which revealed erythematous esophagus and stomach with erosive lesions. Two months later, same study was performed and revealed esophagus and stomach normal mucous membrane.

  6. Five cases of Thermopsis poisoning.

    PubMed

    Spoerke, D G; Murphy, M M; Wruk, K M; Rumack, B H

    1988-01-01

    Various Thermopsis species are found in the foothills and plains of the Rocky Mountains. There are no reported cases of human ingestion to Thermopsis reported in the literature. We report 5 cases of ingestion of seeds or flowers where the primary symptoms were nausea, vomiting and headache of several hours duration. As few as 6 seeds produced symptoms. The common names used by parents when calling the poison center could have easily lead to misidentification and a careful history and subsequent professional identification were required to ascertain the actual plant involved. PMID:3193493

  7. [Occupational arsine poisoning: description of a case].

    PubMed

    Marchiori, L; Rozio, L; Bressan, A; Biasoli, S; Cesaro, A; Peretti, A; Tommasi, I; Perbellini, L

    1989-01-01

    A case of occupational arsine poisoning is described that occurred in a small family workshop during blackening operations on zinc/aluminium alloy manufactured parts with acid solutions. This report shows that occupational poisonings wrongly believed to have disappeared can still occur, especially in small and often unsafe working environments.

  8. Acute arsenic toxicity--an opaque poison.

    PubMed

    Gray, J R; Khalil, A; Prior, J C

    1989-08-01

    We report a patient with fatal acute arsenic poisoning presenting as vomiting and diarrhea with the finding of intra-abdominal radiopacities on radiographs. These represent the classic features of acute arsenic toxicity and are detailed here as a reminder to others facing a similar puzzling patient with this potentially treatable poisoning.

  9. Diagnosis & Treatment of Poisoning by Pesticides.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC. Office of Pesticide Programs.

    This report succinctly discusses the steps necessary to diagnose and treat poisoning from pesticides, especially organophosphates, carbamates and chlorinated hydrocarbons. Immediate and continuing steps in the care of poisoning victims are outlined with supportive information on where to locate emergency assistance. (CS)

  10. Childhood Lead Poisoning: Resources for Prevention.

    ERIC Educational Resources Information Center

    Alliance to End Childhood Lead Poisoning, Washington, DC.

    The current approach to dealing with childhood lead poisoning has led to repeated diagnoses of poisoning because such children are treated and then returned to their hazardous environments. This handbook, the third in a three-volume set, provides examples of specific materials currently or recently used in ongoing state and local childhood lead…

  11. Argument Strategies: Antidote to Tylenol's Poisoned Image.

    ERIC Educational Resources Information Center

    Benoit, William L.; Lindsey, James J.

    1987-01-01

    Analyzes how the manufacturer dealt with the Tylenol poisonings: the link between Tylenol and the poisoning was denied, its image as a safe product was bolstered, capsules were differentiated from other products, and as a result, sales recovered. Extends the applicability of apologia as a way to analyze other media campaigns. (SKC)

  12. Poison control center - Emergency number (image)

    MedlinePlus

    For a poison emergency call 1-800-222-1222 anywhere in the United States. This national hotline number will let you ... is a free and confidential service. All local poison control centers in the U.S. use this national ...

  13. The Poison Control Center--Its Role

    ERIC Educational Resources Information Center

    Manoguerra, Anthony S.

    1976-01-01

    Poison Control Centers are being utilized by more schools of pharmacy each year as training sites for students. This paper discusses what such a center is, its services, changes anticipated in the poison center system in the next several years and how they may influence pharmacy education, specifically as it relates to clinical toxicology.…

  14. Upper gastrointestinal hemorrhage caused by superwarfarin poisoning

    PubMed Central

    Zhao, Shu-Lei; Li, Peng; Ji, Ming; Zong, Ye; Zhang, Shu-Tian

    2010-01-01

    Superwarfarins are a class of rodenticides. Gastrointestinal hemorrhage is a fatal complication of superwarfarin poisoning, requiring immediate treatment. Here, we report a 55-year-old woman with tardive upper gastrointestinal hemorrhage caused by superwarfarin poisoning after endoscopic cold mucosal biopsy. PMID:20355251

  15. Poison Awareness: A Discussion Leader's Guide.

    ERIC Educational Resources Information Center

    National Evaluation Systems, Inc., Amherst, MA.

    Because over 40,000 children are annually poisoned by household products, this guide for group leaders emphasizes hazards and preventive actions. Major objectives are defined: (1) to raise the audience's knowledge/awareness level concerning major hazards associated with potentially poisonous household products, (2) to point out primary hazard…

  16. Management of the critically poisoned patient

    PubMed Central

    Boyle, Jennifer S; Bechtel, Laura K; Holstege, Christopher P

    2009-01-01

    Background Clinicians are often challenged to manage critically ill poison patients. The clinical effects encountered in poisoned patients are dependent on numerous variables, such as the dose, the length of exposure time, and the pre-existing health of the patient. The goal of this article is to introduce the basic concepts for evaluation of poisoned patients and review the appropriate management of such patients based on the currently available literature. Methods An unsystematic review of the medical literature was performed and articles pertaining to human poisoning were obtained. The literature selected was based on the preference and clinical expertise of authors. Discussion If a poisoning is recognized early and appropriate testing and supportive care is initiated rapidly, the majority of patient outcomes will be good. Judicious use of antidotes should be practiced and clinicians should clearly understand the indications and contraindications of antidotes prior to administration. PMID:19563673

  17. Mad honey poisoning mimicking acute myocardial infarction.

    PubMed

    Chen, Sammy P L; Lam, Y H; Ng, Vember C H; Lau, F L; Sze, Y C; Chan, W T; Mak, Tony W L

    2013-08-01

    We report a case of acute poisoning in a 48-year-old man who presented with chest pain, abdominal pain, dizziness, sweatiness, blurred vision, and severe hypotension after ingestion of honey. His electrocardiogram showed sinus bradycardia and transient ST elevation. He made a good recovery after treatment with atropine and close monitoring. Grayanotoxin was detected in his urine and the honey he ingested, which confirmed a diagnosis of mad honey poisoning. This is a condition prevalent in the Black Sea region around Turkey but rarely seen locally. Although mad honey poisoning is life-threatening, early use of atropine is life-saving. Such poisoning may present with ST elevation in the electrocardiogram and symptoms mimicking acute myocardial infarction. It is therefore essential for clinicians to recognise this unusual form of poisoning and avoid the disastrous use of thrombolytic therapy.

  18. [New causes of animal poisoning in Switzerland].

    PubMed

    Schediwy, M; Mevissen, M; Demuth, D; Kupper, J; Naegeli, H

    2015-03-01

    This retrospective study evaluated the frequency, etiology, therapy and prognosis of animal poisoning registered from 2003 to 2012. The relevant cases reported to the Swiss Toxicological Information Center (STIC) were compared with those from previously examined periods. Human medicines not approved for animals and pesticides represented the most common causes of poisoning in dogs. Novel cases occurred as a consequence of the exposure of dogs to ricinus fertilizers, grape residues from wineries, pepper lachrymatory spray and dry bouillon. Cats are still freequently poisoned by pyrethroid drugs that should be administered only to dogs. Agrochmical products are the main source of toxicities in farm animals. Most poisonings in horses and exotic animals took place due to toxic plants. In addition, two tigers died of a secondary poisoning after ingestion of meat from euthanized calves. PMID:26753326

  19. The epidemiology of childhood poisonings in Cyprus.

    PubMed

    Koliou, Maria; Ioannou, Chrystalla; Andreou, Kyriaki; Petridou, Alexandra; Soteriades, Elpidoforos Soterakis

    2010-07-01

    Information on childhood poisonings in Cyprus is limited. Our objective was to examine the epidemiology of poisonings among children in Cyprus. All children up to 15 years of age admitted for poisoning to the Archbishop Makarios Hospital in Nicosia, Cyprus between 2005 and 2008 were included in our study. All hospital poisoning records were reviewed. A total of 257 children were admitted for poisoning. The mean age of children was 3.1 years, of which 83.7% were below the age of 5 years old, while 53% were boys. The poisoning hospitalizations accounted for about 3% of all admissions to the pediatric department during the study period (4 years). The annual cumulative incidence of childhood poisoning hospitalizations was 116 per 100,000 children. Medications accounted for 46.1% of all poisonings, the most frequent cause being paracetamol (9.8%), cardiovascular medications (5.3%), antitussive medications (4.5%), and other painkillers (4.1%). Another 37.6% of hospitalizations involved household products such as household cleaning products (11.8%), petroleum products (11.0%), and rodenticides (5.7%). Among children who ingested petroleum distillates, 55.6% developed clinical symptomatology. The vast majority of cases were accidental (93.8%). Suicidal cases involved children 8-14 years old, mainly girls, and the most frequent poisoning ingested was paracetamol (46.7%). Poisoning hospitalizations represent an important cause of morbidity among children in Cyprus. Preventive strategies should include the education of caregivers on the handling of medications and household products as well as legislation requiring child-resistant packaging for all medications and household products including petroleum distillates.

  20. Lead poisoning in six captive avian species

    USGS Publications Warehouse

    Beyer, W.N.; Spann, J.W.; Sileo, L.; Franson, J.C.

    1988-01-01

    Red-winged blackbirds (Agelaius phoeniceus), brown-headed cowbirds (Molothrus ater), common grackles (Quiscalus quiscula), mallards (Anas platyrhynchos), northern bobwhites (Colinus virginianus), and eastern screech-owls (Otus asio) were poisoned with a concentration of lead (Pb) acetate in the diet which was increased by 60% each week until half of the birds in each treatment group died; surviving birds and all control birds except screech-owis were then killed by euthanasia. An additional group of mallards was poisoned with Pb shot. The gizzards of mallards poisoned either way usually were stained with bile; some of these birds also had proventricular impaction. Most poisoned birds of the other species were emaciated but lacked other gross lesions caused by Pb poisoning. In birds other than mallards, Pb poisoning could not be diagnosed without histological or hematological examinations or analysis of tissues. Poisoned birds of all six species could be reliably separated from control birds by an increase in the protoporphyrin concentrations in the blood and by a decrease in the activity of delta-aminolevulinic acid dehydratase (ALAD) in red blood cells. Hepatic iron (Fe) concentrations varied so much among individual birds that even though median hepatic Fe concentrations increased in poisoned birds, hepatic Fe concentrations were not useful in identifying poisoned birds. Renal intranuclear inclusion bodies occurred in 83% of all birds dying from Pb poisoning. Nephrosis, myocardial necrosis, and arterial fibrinoid necrosis were occasionally present. Median hepatic Pb concentrations varied from 20 ppm (wet wt) in male red-winged blackbirds to 111 ppm in female northern bobwhites. Median renal Pb concentrations varied from 22 ppm in redwinged blackbirds to 190 ppm in female northern bobwhites. Hepatic and renal Pb concentrations varied substantially among birds within each species. Median hepatic and renal Pb concentrations of birds that died were not statistically

  1. Lead poisoning in six captive avian species

    USGS Publications Warehouse

    Beyer, W.N.; Spann, J.W.; Sileo, L.; Franson, J.C.

    1988-01-01

    Red-winged blackbirds (Agelaius phoeniceus), brown-headed cowbirds (Molothrus ater), common grackles (Quiscalus quiscula), mallards (Anas platyrhynchos), northern bobwhites (Colinus virginianus), and eastern screech-owls (Otus asio) were poisoned with a concentration of lead (Pb) acetate in the diet which was increased by 60% each week until half of the birds in each treatment group died; surviving birds and all control birds except screech-owls were then killed by euthanasia. An additional group of mallards was poisoned with Pb shot. The gizzards of mallards poisoned either way usually were stained with bile; some of these birds also had proventricular impaction. Most poisoned birds of the other species were emaciated but lacked other gross lesions caused by Pb poisoning. In birds other than mallards, Pb poisoning could not be diagnosed without histological or hematological examinations or analysis of tissues. Poisoned birds of all six species could be reliably separated from control birds by an increase in the protoporphyrin concentrations in the blood and by a decrease in the activity of delta-aminoievulinic acid dehydratase (ALAD) in red blood cells. Hepatic iron (Fe) concentrations varied so much among individual birds that even though median hepatic Fe concentrations increased in poisoned birds, hepatic Fe concentrations were not useful in identifying poisoned birds. Renal intranuclear inclusion bodies occurred in 83% of all birds dying from Pb poisoning. Nephrosis, myocardial necrosis, and arterial fibrinoid necrosis were occasionally present. Median hepatic Pb concentrations varied from 20 ppm (wet wt) in male red-winged blackbirds to III ppm in female northern bobwhites. Median renal Pb concentrations varied from 22 ppm in red-winged blackbirds to 190 ppm in female northern bobwhites. Hepatic and renal Pb concentrations varied substantially among birds within each species. Median hepatic and renal Pb concentrations of birds that died were not statistically

  2. Open air carbon monoxide poisoning.

    PubMed

    Jumbelic, M I

    1998-01-01

    An unusual manner of carbon monoxide poisoning claimed the lives of two adults in two separate incidents. In the first case, a young man was four wheeling in a swampy area when his jeep became stuck in the mud as he continued to floor the accelerator. Carbon monoxide fumes entered the vehicle through the rusted floorboards, killing the driver. In the second case, two teens were skinny dipping behind a motor boat when they became affected by the boat exhaust. One of the youths was overcome and submerged into the lake. Both incidents were initially attributed to incorrect causes--a car accident and a drowning--because of the false notion that carbon monoxide is not a hazard in a ventilated area. The carboxyhemoglobin levels in these victims were 78 and 62% respectively. It was only through laboratory testing that carbon monoxide poisoning was identified as the cause of their demise. Physicians as well as the public need to be aware of the potential for this life threatening hazard to occur so that there can be proper emergency treatment and the prevention of fatalities.

  3. The treatment of acetaminophen poisoning

    SciTech Connect

    Prescott, L.F.; Critchley, J.A.

    1983-01-01

    Acetaminophen has become a very popular over-the-counter analgesic in some countries and as a result it is used increasingly as an agent for self-poisoning. Without treatment only a minority of patients develop severe liver damage and 1 to 2% die in hepatic failure. Until Mitchell and his colleagues discovered the biochemical mechanisms of toxicity in 1973 there was no effective treatment. They showed that the metabolic activation of acetaminophen resulted in the formation of a reactive arylating intermediate, and that hepatic reduced glutathione played an essential protective role by preferential conjugation and inactivation of the metabolite. Early treatment with sulphydryl compounds and glutathione precursors has been dramatically effective in preventing liver damage, renal failure, and death following acetaminophen overdosage. It seems likely that these agents act primarily by stimulating glutathione synthesis. Inhibition of the metabolic activation of acetaminophen is another potential therapeutic approach that has not yet been put to the test clinically. The clinical management of acetaminophen poisoning has been transformed and it is particularly gratifying to have effective treatment based on a well established biochemical mechanism of toxicity. It is likely that effective treatment will be developed for toxicity caused through similar mechanisms by other agents.

  4. [Acute and chronic cadmium poisoning].

    PubMed

    Andujar, P; Bensefa-Colas, L; Descatha, A

    2010-02-01

    Cadmium is a metallic impurity in various minerals. The two main cadmium exposure sources in general population are food and tobacco smoking. Its industrial exploitation has grown in the early twentieth century. Cadmium is used in accumulators or alkaline batteries (80%) and in pigments for paints or plastics (10%), in electrolytic process by deposit or by cadmium plating on metals or to reduce melting points (welding rods...). Cadmium is a cumulative toxic substance whose half-time for elimination is about 20 to 40 years and it is mainly stored in the liver and kidneys. Inhalation of cadmium oxide fumes may cause inhalation fevers or chemical pneumonitis. Cadmium chronic poisoning causes mainly renal tubulopathy and could be the cause of osteomalacia and diffuse osteoporosis. Cadmium is classified as certain carcinogen agent for humans by International Agency for Research on Cancer (IARC). The most relevant biological index exposure is the urinary cadmium. According to literature, no chelating agent can be still used in human cadmium poisonings. In France, some diseases caused by occupational exposure to cadmium may be compensated.

  5. 49 CFR 172.540 - POISON GAS placard.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON GAS placard. 172.540 Section 172.540... SECURITY PLANS Placarding § 172.540 POISON GAS placard. (a) Except for size and color, the POISON GAS... the POISON GAS placard and the symbol must be white. The background of the upper diamond must be...

  6. 49 CFR 172.416 - POISON GAS label.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false POISON GAS label. 172.416 Section 172.416... SECURITY PLANS Labeling § 172.416 POISON GAS label. (a) Except for size and color, the POISON GAS label... POISON GAS label and the symbol must be white. The background of the upper diamond must be black and...

  7. 49 CFR 172.540 - POISON GAS placard.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false POISON GAS placard. 172.540 Section 172.540... SECURITY PLANS Placarding § 172.540 POISON GAS placard. (a) Except for size and color, the POISON GAS... the POISON GAS placard and the symbol must be white. The background of the upper diamond must be...

  8. 49 CFR 172.540 - POISON GAS placard.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false POISON GAS placard. 172.540 Section 172.540... SECURITY PLANS Placarding § 172.540 POISON GAS placard. (a) Except for size and color, the POISON GAS... the POISON GAS placard and the symbol must be white. The background of the upper diamond must be...

  9. 49 CFR 172.416 - POISON GAS label.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false POISON GAS label. 172.416 Section 172.416... SECURITY PLANS Labeling § 172.416 POISON GAS label. (a) Except for size and color, the POISON GAS label... POISON GAS label and the symbol must be white. The background of the upper diamond must be black and...

  10. 49 CFR 172.416 - POISON GAS label.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON GAS label. 172.416 Section 172.416... SECURITY PLANS Labeling § 172.416 POISON GAS label. (a) Except for size and color, the POISON GAS label... POISON GAS label and the symbol must be white. The background of the upper diamond must be black and...

  11. 49 CFR 172.416 - POISON GAS label.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false POISON GAS label. 172.416 Section 172.416... SECURITY PLANS Labeling § 172.416 POISON GAS label. (a) Except for size and color, the POISON GAS label... POISON GAS label and the symbol must be white. The background of the upper diamond must be black and...

  12. 49 CFR 172.540 - POISON GAS placard.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false POISON GAS placard. 172.540 Section 172.540... SECURITY PLANS Placarding § 172.540 POISON GAS placard. (a) Except for size and color, the POISON GAS... the POISON GAS placard and the symbol must be white. The background of the upper diamond must be...

  13. Recognition and management of acute pesticide poisoning.

    PubMed

    Simpson, William M; Schuman, Stanley H

    2002-04-15

    Most poisonings from pesticides do not have a specific antidote, making decontamination the most important intervention. For maximal benefit to the patient, skin, eye, and gastric decontamination should be undertaken while specifics of the poisoning are being determined. As in most illnesses and injuries, the history of the poisoning is of great importance and will determine specific needs for decontamination and therapy, if any exist. Protection of health care workers during the decontamination process is important and frequently overlooked. Skin decontamination is primarily accomplished with large volumes of water, soap, and shampoo. Gastric decontamination by lavage is indicated if ingestion of the poisoning has occurred within 60 minutes of patient presentation. Activated charcoal, combined with a cathartic, is also indicated in most poisonings presenting within 60 minutes of ingestion. With large volume ingestion poisonings, activated charcoal may be used after 60 minutes, but little data exist to support this practice. Syrup of ipecac is no longer recommended for routine use. The cholinergic syndrome "all faucets on" characterizes poisoning by organophosphates and carbamates. Organochlorine insecticides (lindane and other treatments for scabies and lice) can produce seizures with excessive use or use on large areas of nonintact skin. Non-dipyridyl herbicides, biocides (including pyrethrins, pyrethroids, and Bacillus thuringiensis) rarely produce anything other than mild skin, eye, and/or gastrointestinal irritation on topical exposure or ingestion.

  14. [Descriptive epidemiology of mushroom poisoning in Japan].

    PubMed

    Ishihara, Y; Yamaura, Y

    1992-02-01

    The Incidence of mushroom poisoning was surveyed statistically from 1959 to 1988 in Japan. The results are summarized as follows: 1. During the past three decades, the total number of incidents of mushroom poisoning was 2,096, which involved 10,924 patients and 72 deaths. The average number of incidents was 70 cases per year, involving 364 patients and 2.4 deaths, and the number of incidents decreased gradually every year. Mushroom poisoning usually happened most frequently in September and October. 2. Considering regional differences, the incidence of mushroom poisoning was more frequent in the northeastern part of Japan than in the southwestern part. The incidences of mushroom poisoning in the prefectures of Nagano, Hokkaido, Niigata, Iwate and Fukushima were relatively high. 3. Three species of mushrooms, L. japonicus, R. rhodopolius (R. sinuatus) and T. ustale caused the majority of all poisonings. 4. The rates of total patients and fatalities for each type of poisoning, which were classified according to the symptoms caused, were 90.3% and 10.7% in the type with cholera-like symptoms, 90.2% and 0.2% in that with gastro-intestinal irritation, and 74.1% and 0% in that with neurological symptoms, respectively. PMID:1556831

  15. Hyperbaric oxygen therapy for carbon monoxide poisoning.

    PubMed

    Weaver, Lindell K

    2014-01-01

    Despite established exposure limits and safety standards, and the availability of carbon monoxide (CO) alarms, each year 50,000 people in the United States visit emergency departments for CO poisoning. Carbon monoxide poisoning can occur from brief exposures to high levels of CO, or from longer exposures to lower levels. Common symptoms include headaches, nausea and vomiting, dizziness, general malaise, and altered mental status. Some patients may have chest pain, shortness of breath and myocardial ischemia, and may require mechanical ventilation and treatment of shock. Individuals poisoned by CO often go on to develop neurological problems, including cognitive sequelae, anxiety and depression, persistent headaches, dizziness, sleep problems, motor weakness, vestibular and balance problems, gaze abnormalities, peripheral neuropathies, hearing loss, tinnitus and Parkinsonian-like syndrome. While breathing oxygen hastens the removal of carboxyhemoglobin (COHb), hyperbaric oxygen (HBO2) hastens COHb elimination and favorably modulates inflammatory processes instigated by CO poisoning, an effect not observed with breathing normobaric oxygen. Hyperbaric oxygen improves mitochondrial function, inhibits lipid peroxidation transiently, impairs leukocyte adhesion to injured microvasculature, and reduces brain inflammation caused by the CO-induced adduct formation of myelin basic protein. Based upon three supportive randomized clinical trials in humans and considerable evidence from animal studies, HBO2 should be considered for all cases of acute symptomatic CO poisoning. Hyperbaric oxygen is indicated for CO poisoning complicated by cyanide poisoning, often concomitantly with smoke inhalation.

  16. Suspected poisoning of domestic animals by pesticides.

    PubMed

    Caloni, Francesca; Cortinovis, Cristina; Rivolta, Marina; Davanzo, Franca

    2016-01-01

    A retrospective study was carried out by reviewing all suspected cases of domestic animal poisoning attributed to pesticides, reported to the Milan Poison Control Centre (MPCC) between January 2011 and December 2013. During this period, pesticides were found to be responsible for 37.3% of all suspected poisoning enquiries received (815). The most commonly species involved was the dog (71.1% of calls) followed by the cat (15.8%), while a limited number of cases involved horses, goats and sheep. Most cases of exposure (47.1%) resulted in mild to moderate clinical signs. The outcome was reported in 59.9% of these cases, with death occurring in 10.4% of them. Insecticides (40.8%) proved to be the most common group of pesticides involved and exposure to pyrethrins-pyrethroids accounted for the majority of calls. According to the MPCC data, there has been a decrease in the number of suspected poisonings cases attributed to pesticides that have been banned by the EU, including aldicarb, carbofuran, endosulfan and paraquat. In contrast, there has been an increase of suspected poisoning cases attributed to the neonicotinoids, imidacloprid and acetamiprid, probably due to their widespread use in recent years. Cases of suspected poisoning that involved exposure to rodenticides accounted for 27.6% of calls received by the MPCC and anticoagulant rodenticides were the primary cause of calls, with many cases involving brodifacoum and bromadiolone. Herbicides were involved in 14.2% of calls related to pesticides and glyphosate was the main culprit in cases involving dogs, cats, horses, goats and sheep. As far as exposure to molluscicides (11.5%) and fungicides (5.9%), most of the cases involved dogs and the suspected poisoning agents were metaldehyde and copper compounds respectively. The data collected are useful in determining trends in poisoning episodes and identifying newly emerging toxicants, thus demonstrating the prevalence of pesticides as causative agents in animal

  17. Suspected poisoning of domestic animals by pesticides.

    PubMed

    Caloni, Francesca; Cortinovis, Cristina; Rivolta, Marina; Davanzo, Franca

    2016-01-01

    A retrospective study was carried out by reviewing all suspected cases of domestic animal poisoning attributed to pesticides, reported to the Milan Poison Control Centre (MPCC) between January 2011 and December 2013. During this period, pesticides were found to be responsible for 37.3% of all suspected poisoning enquiries received (815). The most commonly species involved was the dog (71.1% of calls) followed by the cat (15.8%), while a limited number of cases involved horses, goats and sheep. Most cases of exposure (47.1%) resulted in mild to moderate clinical signs. The outcome was reported in 59.9% of these cases, with death occurring in 10.4% of them. Insecticides (40.8%) proved to be the most common group of pesticides involved and exposure to pyrethrins-pyrethroids accounted for the majority of calls. According to the MPCC data, there has been a decrease in the number of suspected poisonings cases attributed to pesticides that have been banned by the EU, including aldicarb, carbofuran, endosulfan and paraquat. In contrast, there has been an increase of suspected poisoning cases attributed to the neonicotinoids, imidacloprid and acetamiprid, probably due to their widespread use in recent years. Cases of suspected poisoning that involved exposure to rodenticides accounted for 27.6% of calls received by the MPCC and anticoagulant rodenticides were the primary cause of calls, with many cases involving brodifacoum and bromadiolone. Herbicides were involved in 14.2% of calls related to pesticides and glyphosate was the main culprit in cases involving dogs, cats, horses, goats and sheep. As far as exposure to molluscicides (11.5%) and fungicides (5.9%), most of the cases involved dogs and the suspected poisoning agents were metaldehyde and copper compounds respectively. The data collected are useful in determining trends in poisoning episodes and identifying newly emerging toxicants, thus demonstrating the prevalence of pesticides as causative agents in animal

  18. Methadone toxicity in a poisoning referral center

    PubMed Central

    Taheri, Fatemeh; Yaraghi, Ahmad; Sabzghabaee, Ali Mohammad; Moudi, Maryam; Eizadi-Mood, Nastaran; Gheshlaghi, Farzad; Farajzadegan, Ziba

    2013-01-01

    Objective: Methadone poisoning can occur accidentally or intentionally for suicide or homicide purposes. The aim of this study was to evaluate the epidemiological and clinical manifestations of Methadone poisoning. Methods: A descriptive analytical study was performed from 2010 to 2012 in the poisoning emergency and clinical toxicology departments of Noor hospital affiliated with Isfahan University of Medical Sciences (Isfahan, Iran). All patients with Methadone poisoning within this period of time were investigated. Different variables were recorded in a checklist. Findings: A total of 385 patients were studied. About 85.7% had ingested only Methadone and 14.3% had ingested other medications with Methadone. Mean ± standard deviation of the age was 32.1 ± 15 years (range: 1-90). Most of the patients were male (76.4%). Nearly 40% of the patients were narcotic addicts, 25.5% were addicts under surveillance of Methadone maintenance therapy centers and 34.5% were non-addicts. Intentional poisoning was observed in most of the patients (57.7%). Most of the patients had a low level of consciousness on admission (58.2%). Respiratory depression and hypotension was observed in 35.6% and 12.7% of the cases as the most common symptoms. Regarding vital signs, there was a significant difference in respiratory rate on admission among different evaluated groups (P = 0.02). Length of hospital stay was 18.79 ± 0.72 h (range: 4-240 h, median: 15 h). About 57 patients (25.8%) from the intentionally poisoned patients and 19 patients (12.3%) from the unintentionally poisoned patients had a history of psychiatric disorder (P = 0.001). Most of the patients survived without complications. Conclusion: Addiction, age, gender, attempt to suicide and a history of psychiatric disorder were of the most important factors effective in Methadone poisoning, which should be considered in the public training and prevention of poisoning. PMID:24991620

  19. Five cases of arsine poisoning.

    PubMed

    Phoon, W H; Chan, M O; Goh, C H; Edmondson, R P; Kwek, Y K; Gan, S L; Ngui, S J; Kwok, S F

    1984-04-01

    Arsine is one of the most potent haemolytic agents found in industry. Four workers presented with abdominal pain, jaundice and passing tea-coloured urine. A fifth worker also passed dark urine but had no other symptoms. Investigation revealed that all five workers were from a tin smelting plant where they were involved in mixing tin ore with dross. They were exposed to arsine gas after mixing a particularly large quantity of dross with tin ore which was wet because of rain. Three of the cases developed renal impairment and also a mild sensory neuropathy. All survived with proper management in hospital which included exchange blood transfusions, and peritoneal dialysis where indicated. Prevention of such poisoning includes keeping dross away from all moisture, good ventilation in work areas, and adding dross directly to the furnace.

  20. Carbon monoxide: an old poison with a new way of poisoning.

    PubMed

    Chou, Cheng-Hsiu; Lai, Ching-Huang; Liou, Saou-Hsing; Loh, Ching-Hui

    2012-08-01

    We present two events of carbon monoxide (CO) poisoning, which spread out through ventilation pipes to kill or injure neighbors. This is a previously undocumented poisoning process. In the first event, three people died and eight others suffered CO poisoning from a gas-powered water heater in an apartment building. Similar to the first event, three people expired and three others were injured by CO poisoning in the second event. We subsequently determined the cause of these tragedies were due to obstructions at the openings of ventilation pipes. CO is one of the most common causes of poisoning worldwide and these cases often result in tragedy. Early recognition of CO poisoning resulting from obstructed ventilation pipes will facilitate proper management and prevent possible lethal disasters. Additionally, all clinicians and other paramedical personnel ought to raise the suspicion of chemical-related casualties when encountering clusters of patients from a single locale.

  1. Radiographic findings in congenital lead poisoning

    SciTech Connect

    Pearl, M.; Boxt, L.M.

    1980-07-01

    Because lead crosses the placenta throughout pregnancy, the fetus is at risk for lead poisoning. A full term, asymptomatic child was born with congenital lead poisoning secondary to maternal pica. Radiographic findings of a dense cranial vault, lead lines, and delayed skeletal and deciduous dental development were noted at birth. After chelation therapy, when the patient was seven months old, radiographs revealed normal skeletal maturation. Tooth eruption did not occur until 15 months of age. Newborn infants with these radiographic findings should be screened for subclinical, congenital lead poisoning.

  2. Metal Poisons in Waste Tanks (U)

    SciTech Connect

    Williamson, T.G.

    1996-10-14

    Many of the storage tanks with waste from processing fissile materials contain, along with the fissile material, metals which may serve as nuclear criticality poisons. It would be advantageous to the criticality evaluation of these wastes if it can be demonstrated that the poisons remain with the fissile materials and if an always safe poison-to-fissile ratio can be established. The first task, demonstrating that the materials stay together, is the job of the chemist, the second, demonstrating an always safe ratio, is the job of the physicist. The latter task is the object of this paper

  3. Childhood poisoning: the scope for prevention.

    PubMed

    Chan, T Y

    1998-12-01

    Many deaths and disabling sequelae in children following poisoning could be prevented if more attention were given to implementing preventive measures at home. Medications and chemicals should always be safely packed and stored. Education on which products are highly dangerous and the giving of precautionary advice to parents would also help to reduce the incidence of childhood poisoning. In Hong Kong, imported vegetables (contaminated by methamidophos) and coral reef fish (containing ciguatoxins) cause poisoning in both children and adults. Advice on preventive measures should be given to the public.

  4. Phosphide poisoning: a review of literature.

    PubMed

    Bumbrah, Gurvinder Singh; Krishan, Kewal; Kanchan, Tanuj; Sharma, Madhulika; Sodhi, Gurvinder Singh

    2012-01-10

    Metal phosphides in general and aluminium phosphide in particular are potent insecticides and rodenticides. These are commercially used for protection of crops during storage, as well as during transportation. However, these are highly toxic substances. Their detrimental effects may range from nausea and headache to renal failure and death. It is, therefore, pertinent to ensure their circumspect handling to avoid poisoning episodes. Its poisoning has a high mortality and recent years have seen an increase in the number of poisoning cases and deaths caused by suicidal ingestion. Yet due to their broad spectrum applications, these chemicals cannot be written off. The present communication reviews the various aspects of toxicity associated with metal phosphides.

  5. An Unusual Cause of Carbon Monoxide Poisoning: Narghile Smoking.

    PubMed

    Ateş, Alpay; Arikan, Müge; Özgök, Ayşegul

    2016-01-01

    BACKGROUND Carbon monoxide (CO) poisoning is commonly seen during the winter season in Turkey due to use of charcoal stoves and water heaters, but narghile smoking is a rare cause of CO poisoning. CASE REPORT In this paper, we report a CO poisoning case caused by narghile smoking. The patient was admitted to the ED with nausea, dizziness, vertigo, and syncope. CONCLUSIONS The diagnosis of CO poisoning depends on suspicious anamnesis. The major treatment of CO poisoning is oxygen supply. PMID:27618983

  6. Remembering the First World War: Using a Battlefield Tour of the Western Front to Help Pupils Take a More Critical Approach to What They Encounter

    ERIC Educational Resources Information Center

    Freeman, Jerome

    2014-01-01

    The first year of the government's First World War Centenary Battlefield Tours Programme is now under way, allowing increasing numbers of students from across Britain to visit Western Front battle sites. As its Programme Director, Jerome Freeman has sought to encourage teachers to make these visits meaningful and historically rigorous. He…

  7. Mobile chemical detector (AP2C+SP4E) as an aid for medical decision making in the battlefield.

    PubMed

    Eisenkraft, Arik; Markel, Gal; Simovich, Shirley; Layish, Ido; Hoffman, Azik; Finkelstein, Arseny; Rotman, Eran; Dushnitsky, Tsvika; Krivoy, Amir

    2007-09-01

    The combination of the AP2C unit with the SP4E kit composes a lightweight mobile detector of chemical warfare agents (CWA), such as nerve and mustard agents, with both vapor- and liquid-sampling capabilities. This apparatus was recently introduced into our military medical units as an aid for detection of CWA on casualties. Importantly, critical information regarding the applicability in the battlefield was absent. In view of the serious consequences that might follow a proclamation of CWA recognition in battlefield, a high false-positive rate positions the utilization of this apparatus as a medical decision tool in question. We have therefore conducted a field experiment to test the false-positive rate as well as analyze possible factors leading to false-positive readings with this device. The experiment was carried out before and after a 4-day army field exercise, using a standard AP2C device, a SP4E surface sampling kit, and a specially designed medical sampling kit for casualties, intended for medical teams. Soldiers were examined at rest, after mild exercise, and after 4 days in the field. The readings with AP2C alone were compared to the combination of AP2C and SP4E and to the medical sampling kit. Various body fluids served as negative controls. Remarkably, we found a false-positive rate of 57% at rest and after mild exercise, and an even higher rate of 64% after the 4-day field exercise with the AP2C detector alone, as compared to almost no false-positive readings with the combination of AP2C and SP4E. Strikingly, the medical sampling kit has yielded numerous false-positive readings, even in normal body fluids such as blood, urine, and saliva. We therefore see no place for using the medical sampling kit due to an unaccepted high rate of false-positive readings. Finally, we have designed an algorithm that uses the entire apparatus of AP2C and SP4E as a reliable validation tool for medical triage in the setting of exposure to nerve agents in the battlefield.

  8. Depletion optimization of lumped burnable poisons in pressurized water reactors

    SciTech Connect

    Kodah, Z.H.

    1982-01-01

    Techniques were developed to construct a set of basic poison depletion curves which deplete in a monotonical manner. These curves were combined to match a required optimized depletion profile by utilizing either linear or non-linear programming methods. Three computer codes, LEOPARD, XSDRN, and EXTERMINATOR-2 were used in the analyses. A depletion routine was developed and incorporated into the XSDRN code to allow the depletion of fuel, fission products, and burnable poisons. The Three Mile Island Unit-1 reactor core was used in this work as a typical PWR core. Two fundamental burnable poison rod designs were studied. They are a solid cylindrical poison rod and an annular cylindrical poison rod with water filling the central region.These two designs have either a uniform mixture of burnable poisons or lumped spheroids of burnable poisons in the poison region. Boron and gadolinium are the two burnable poisons which were investigated in this project. Thermal self-shielding factor calculations for solid and annular poison rods were conducted. Also expressions for overall thermal self-shielding factors for one or more than one size group of poison spheroids inside solid and annular poison rods were derived and studied. Poison spheroids deplete at a slower rate than the poison mixture because each spheroid exhibits some self-shielding effects of its own. The larger the spheroid, the higher the self-shielding effects due to the increase in poison concentration.

  9. Sources, symptoms, and signs of arsenic poisoning.

    PubMed

    Hutton, J T; Christians, B L

    1983-09-01

    Arsenic poisoning continues to be a serious medical problem that may easily be overlooked or misdiagnosed. The broad constellation of symptoms and signs in arsenic poisoning, along with changing sources of this toxin, contributes to misdiagnosis. A re-examination of current potential sources was carried out. Sources were determined in 17 of 20 documented cases of arsenic poisoning. Fourteen cases resulted from ingestion of a single, commonly available, arsenic-containing ant killer. In contrast to earlier reports, this survey found that agricultural and industrial sources were relatively uncommon. A peculiar posturing of the hand is commonly seen in the early stages of arsenic poisoning prior to the development of Mee's lines or palmar hyperkeratosis. An illustrative case is reported that resulted from intermittent self-administration of an arsenic-containing ant killer in order to maintain a state of chronic invalidism.

  10. Poison oak rash on the arm (image)

    MedlinePlus

    ... appearance of poison oak dermatitis. Note the typical linear streaks produced either by scratching or brushing against the plant. (Image courtesy of the Centers for Disease Control and Prevention.)

  11. Laundry detergent capsules and pediatric poisoning

    PubMed Central

    Bonney, Asha G.; Mazor, Suzan; Goldman, Ran D.

    2013-01-01

    Abstract Question A 4-year-old girl was brought into the emergency department vomiting after having had ingested a laundry detergent capsule (LDC) from under the sink at her house. What is the risk of LDC poisoning? What can be done to treat these children? Answer Laundry detergent capsules are relatively new to supermarket shelves in North America, and there has been an emergence of case reports in the literature describing LDC poisoning, which is worse than poisoning from other laundry detergents. Very little is known about the mechanisms causing these severe reactions, which include airway compromise and esophageal perforation, but the attractive appearance of these capsules and easy access at home has governments and health officials concerned about an increase in poisoning. No residual problems have been associated with these cases to date; however, further research is needed to assess long-term effects. PMID:24336541

  12. Clinical manifestations of tansy ragwort poisoning.

    PubMed

    Pearson, E G

    1977-05-01

    The clinical signs of tansy ragwort poisoning are variable and in 5 cases included diarrhea, tenesmus, ascites, bloody feces, icterus, paresis, CNS involvement, rectal prolapse, poor appetite and weight loss. It is thus apparent that the disease can be confused clinically with many others, and tansy ragwort poisoning should be considered in animals exhibiting ascites, diarrhea and rectal prolapse. Several cases of tansy ragwort (Senecio jacobaea) poisoning occurring from 1969 to 1976 are reported to illustrate the numerous clinical pictures that might confront a practitioner. The disease is sporadic in this area. The poisonous principles in tansy ragwort are pyrrolizidine alkaloids, which cause gradual alteration and necrosis of liver cells with replacement by fibrous tissue. The development of signs in all of these cases could be attributed to failure of one or more liver functions.

  13. Lead poisoning in a Mississippi sandhill crane

    USGS Publications Warehouse

    Franson, J. Christian; Hereford, Scott G.

    1994-01-01

    Lead poisoning from the ingestion of spent lead shot is well documented in waterfowl (Sanderson and Bellrose 1986) and has been reported in other wetland (Locke et al. 1991, Windingstad et al. 1984) and upland (Hunter and Rosen 1965, Locke and Bagley 1967) avian species. Ingested fishing weights have been implicated in lead poisoning of Trumpeter Swans (Cygnus buccinator) (Blus et al. 1989), Common Loons (Gavia immer) (Locke et al. 1982, Franson and Cliplef 1992, Pokras and Chafe1 1992), Mute Swans (Cygnus olor) (Birkhead 1982), and Sandhill Cranes (Grus canadensis) (Windingstad et al. 1984). The significance of lead poisoning as a mortality factor in avian species other than waterfowl is probably underestimated (Locke and Friend 1992), and any cause of mortality becomes particularly important in species with small population sizes. We report here the first known case of lead poisoning in a Mississippi Sandhill Crane (Grus canadensis pulla), a critically endangered subspecies.

  14. Lead Poisoning and the Suburban Child

    ERIC Educational Resources Information Center

    Graham, Ada; Graham, Frank

    1974-01-01

    Reports on recent findings which suggest that lead poisoning stems not only from paint ingestion, is not limited to ghetto children, and may be linked to some learning and behavioral difficulties in children. (Author/SF)

  15. Lead Poisoning in Remodeling of Old Homes

    ERIC Educational Resources Information Center

    Barnes, Bart

    1973-01-01

    An article based on Dr. Muriel D. Wolf's study of elevated blood lead levels in children and adults present during the remodeling of old homes. Lead poisoning examples, symptoms, and precautions are given. (ST)

  16. Lunar cycle and poison center calls.

    PubMed

    Oderda, G M; Klein-Schwartz, W

    1983-07-01

    An analysis of calls to the Maryland Poison Center was performed to assess whether a relationship exists between the moon periods and poison exposure calls. A given period was defined as the day of the lunar event +/- 2 days. Thirteen lunar cycles in which 22,079 calls occurred were analyzed. A larger proportion of total calls to the center and unintentional poisoning calls occurred during the full moon period. A significantly larger number of unintentional poisonings occurred in the full moon period compared to suicide attempts and drug abuse which occurred most frequently during the new moon period. The lunar cycle had no effect on the distribution of victim's age or sex or the location of treatment.

  17. [Acute poisoning. Apropos of 1200 cases].

    PubMed

    Ginies, G; Lamisse, F; Gautier, J; Choutet, P; Breteau, M; Bourin, M; Renard, J P

    The team studied 1 200 cases of acute intoxications both accidental and self inflicted, self inflicted poisonings are much more frequent than accidental ones and in general occur more often amongst the young and by women; the median age is about thirty. Barbituric are often the means. There is a progressive increase in the use of tranquilizers and of thymo-analeptics as their use becomes greater. A mixture of poisons increases the dangers because this frequently results in more rapid loss of consciousness; also more than one poison increases the risk of shock and of thermo-regulation, respiratory problems necessitate intubation and artificial respiration which both increase the risk of assification. The characteristics of certain poisons are stressed and in particular the thymo-analeptics; also the supervision of the patients in an intensive care unit.

  18. Carbamate and organophosphate poisoning in early childhood.

    PubMed

    Sofer, S; Tal, A; Shahak, E

    1989-12-01

    Twenty-five infants and young children intoxicated by carbamate and organophosphorus compounds are described. Presenting signs and symptoms in children differed from those described in adults and were mainly related to severe CNS depression, coma and stupor, dyspnea, and flaccidity. Other clinical signs such as miosis, excessive salivation and tearing, sweaty, cold skin, and gastrointestinal symptoms were less frequent, while fasciculations and bradycardia were quite uncommon on arrival. Only two patients presented with all typical signs of organophosphate poisoning as described in adults. Signs of carbamate poisoning were indistinguishable from those of organophosphate poisoning and included signs of myoneural and CNS cholinergic receptor involvement, in addition to parasympathetic muscarinic dysfunction. Atropine sulfate was found to have a clear beneficial CNS effect in addition to its known peripheral antimuscarinic effect. Our data suggest that the clinical presentation of carbamate and organophosphate poisoning in early childhood and its response to therapy are quite different from those of adults and older children.

  19. Arsenic poisoning. Ongoing diagnostic and social problem.

    PubMed

    Fuortes, L

    1988-01-01

    Arsenic, commonly found in insecticides, herbicides, and industrial materials, is involved in the majority of heavy metal poisonings reported in the United States. Accidental poisoning appears to be most common in the pediatric age-group, whereas intentional and covert poisonings predominate in adults. Diagnosis is often difficult. The clinical presentations of arsenic poisoning, both acute and chronic types, represent a wide spectrum, largely dependent on route of exposure, chemical form, and dose. Because the patient or others providing the history may suppress information on exposure and because toxic levels of arsenic in the system drop rapidly in the first 24 hours, swift administration of diagnostic tests is important. Physician follow-up is determined by the route of exposure to arsenic and may involve referral to a social service network or a mental health facility.

  20. Protecting Children from Carbon Monoxide Poisoning

    MedlinePlus

    ... monoxide poisoning increases after disasters when gasoline- or diesel-powered generators may be more frequently used to ... can mimic symptoms of sea sickness. Schedule regular engine and exhaust system maintenance. Consider installing a carbon ...

  1. Red Tide and Paralytic Shellfish Poisoning

    ERIC Educational Resources Information Center

    Dale, Barrie; Yentsch, Clarice M.

    1978-01-01

    Discusses the nature and cause of paralytic shellfish poisoning (PSP). Includes toxic dinoflagellate ecology, taxonomy and life history, and chemistry of the toxins. Recent work with trace metals and directions of future research are also given. (MA)

  2. Acute arsenic poisoning: clinical and histopathological features.

    PubMed

    Bartolomé, B; Córdoba, S; Nieto, S; Fernández-Herrera, J; García-Díez, A

    1999-12-01

    We report a woman with acute arsenic poisoning, who developed an erythroderma with vesicles and pustules after the ingestion of 8-16 g of sodium arsenite. Simultaneously, she presented a herpes simplex virus infection. Skin biopsies showed unique features which included multiple small pigment granules inside and outside the histiocytes. In our opinion, these findings are consistent with acute arsenic poisoning, and constitute the first histological description of this entity in skin.

  3. [Torsades de pointes during sultopride poisoning].

    PubMed

    Montaz, L; Varache, N; Harry, P; Aymes, C; Turcant, A; Delille, F; Simonin, D; Hass, C

    1992-12-01

    A case of sultopride poisoning (ingested dose 16 g) in a 35-year-old, 65 Kg man is described. On admission myoclonus, mydriasis, vomiting and cardio-respiratory arrest were observed. Torsades de pointes were treated with potassium chloride infusion and pace maker stimulation. Plasma sultopride concentration was 25 mg/l and urinary concentration 12 g/l. A prolongation of Q-T interval may announce severe arrhythmias in sultopride poisoning.

  4. [Acute cyanide poisoning in an infant].

    PubMed

    Haasnoot, K; van Vught, A J; Meulenbelt, J; Bergman, L R

    1989-09-01

    An infant of 9 months was admitted to hospital in comatose condition; cyanide poisoning was suspected. This poisoning was caused by the desorption of hydrocyanic acid from building materials after the house had been fumigated with hydrocyanic acid under strict supervision and observed safety measures. Administration of 4-dimethyl-aminophenol, a methaemoglobin inducer, and sodium thiosulphate together with supportive measures, led to complete recovery of the infant, although the general hypotony persisted for a few weeks. PMID:2797290

  5. Cholestatic presentation of yellow phosphorus poisoning.

    PubMed

    Lakshmi, C P; Goel, Amit; Basu, Debdatta

    2014-01-01

    Yellow phosphorus, a component of certain pesticide pastes and fireworks, is well known to cause hepatotoxicity. Poisoning with yellow phosphorus classically manifests with acute hepatitis leading to acute liver failure which may need liver transplantation. We present a case of yellow phosphorus poisoning in which a patient presented with florid clinical features of cholestasis highlighting the fact that cholestasis can rarely be a presenting feature of yellow phosphorus hepatotoxicity. PMID:24554916

  6. Facts and fallacies on industrial poisoning.

    PubMed

    THIENES, C H

    1957-09-01

    Misdiagnosis of diseases as due to industrial poisoning leads to much misunderstanding, higher taxes and insurance rates and "compensation neuroses." It is important to know the concentration of the suspected poison and its specific effects in order to logically indict it as the cause of illness. Examples discussed to illustrate some of the pitfalls of diagnosis in industrial medicine are methylbromide, carbon monoxide, ozone, oxides of nitrogen and of sulfur, hydrogen sulfide, benzene analogs, boron and fluorides. PMID:13460717

  7. Ciguatera poisoning in the Cook Islands

    PubMed Central

    Bailey, Stephanie; Withers, Tristan

    2014-01-01

    This case report presents two British medical students who contracted ciguatera poisoning while on elective in the Cook Islands. Thirty-six hours after consuming two reef fish they developed paraesthesia of the mouth, hands and feet, myalgia, pruritis and cold allodynia. Neurological examination was normal. Diagnosis of ciguatera poisoning was made on history of reef fish consumption and classical clinical presentation. Management was symptomatic (antihistamines) and both students made a full recovery within 10 weeks. PMID:24966268

  8. Conversion From Limb Salvage to Late Amputation: Lessons Learned From Recent Battlefields With Application to Civilian Trauma.

    PubMed

    Covey, D C

    2015-01-01

    Battlefield injuries and high-energy civilian trauma present orthopaedic surgeons with treatment challenges. Despite efforts at limb salvage, some patients elect late amputation. This article reviews risk factors that predispose to late amputation. Using a MEDLINE search, English language peer-reviewed articles from 1993 to 2013 having data on late amputation following limb salvage were included. Late lower extremity amputation after limb salvage varied from 3.9% to 40% in civilian patients and from 5.2% to 15.2% in military patients. Factors influencing a patient's decision to undergo late amputation included a combination of complex pain symptoms with neurologic dysfunction, infection, a desire for improved limb functionality, and unwillingness to endure an often complicated and lengthy course of treatment. In military patients, rank was a significant risk factor since officers were 2.5 times more likely to elect late amputation (p < .05) than enlisted personnel. Despite often extraordinary efforts towardlimb salvage, results maybe disappointing.

  9. From the battlefield to the laboratory: the use of clinical data analysis in developing models of lower limb blast injury.

    PubMed

    Ramasamy, Arul; Newell, N; Masouros, S

    2014-06-01

    A key weapon in the insurgents' armamentarium against coalition and local security forces in Iraq and Afghanistan has been the use of anti-vehicle mines and improvised explosive devices (IEDs). Often directed against vehicle-borne troops, these devices, once detonated, transfer considerable amounts of energy through the vehicle to the occupants. This results in severe lower limb injuries that are frequently limb threatening. Fundamental to designing novel mitigation strategies is a requirement to understand the injury mechanism by developing appropriate injury modelling tools that are underpinned by the analysis of contemporary battlefield casualty data. This article aims to summarise our understanding of the clinical course of lower limb blast injuries from IEDs and its value in developing unique injury modelling test-beds to evaluate and produce the next generation of protective equipment for reducing the devastating effects of blast injury.

  10. Hearts and flowers: Bryophyllum poisoning of cattle.

    PubMed

    McKenzie, R A; Dunster, P J

    1986-07-01

    Findings from natural cases and experiments with cattle emphasise that flowering plants are the most important form of Bryophyllum (Kalanchoe) spp in poisonings in Australia. The main life-threatening lesion is myocardial. The effects on the alimentary tract are less important than was believed previously. B. tubiflorum, B. daigremontianum x B. tubiflorum, B. pinnatum and B. proliferum caused 41 recorded poisoning incidents affecting 379 cattle in Queensland between 1960 and 1984. Poisoning occurred between May and October--the flowering season of these plants. Experimental B. tubiflorum poisoning and natural poisonings produced anorexia, depression, ruminal atony, diarrhoea, heart rate and rhythm abnormalities, dyspnoea and death. Increased plasma concentrations of urea, creatinine and glucose and decreased chloride were measured experimentally. Both natural and experimental cases had myocardial degeneration and necrosis with haemorrhages of the heart and alimentary tract. Cattle with severe dyspnoea had atelectasis and emphysema of the lungs. Some cattle had mild nephrosis. The median lethal doses of B. tubiflorum flowers, roots and leaf plus stem were 0.7, 2.3 and 5.0 g dry matter/kg liveweight respectively (7, 7 and 40 g wet weight/kg). Bufadienolides have been isolated recently from B. tubiflorum flowers and the syndrome is consistent with cardiac glycoside poisoning. PMID:3778371

  11. Acute Plant Poisoning and Antitoxin Antibodies

    PubMed Central

    Eddleston, Michael; Persson, Hans

    2007-01-01

    Plant poisoning is normally a problem of young children who unintentionally ingest small quantities of toxic plants with little resulting morbidity and few deaths. In some regions of the world, however, plants are important clinical problems causing much morbidity and mortality. While deaths do occur after unintentional poisoning with plants such as Atractylis gummifera (bird-lime or blue thistle) and Blighia sapida (ackee tree), the majority of deaths globally occur following intentional self-poisoning with plants such as Thevetia peruviana (yellow oleander) and Cerbera manghas (pink-eyed cerbera or sea mango). Antitoxins developed against colchicine and cardiac glycosides would be useful for plant poisonings - anti-digoxin Fab fragments have been shown to be highly effective in T. peruviana poisoning. Unfortunately, their great cost limits their use in the developing world where they would make a major difference in patient management. Therapy for some other plant poisonings might also benefit from the development of antitoxins. However, until issues of cost and supply are worked out, plant anti-toxins are going to remain a dream in many of the areas where they are now urgently required. PMID:12807314

  12. PLANT POISONING IN THAILAND: A 10-YEAR ANALYSIS FROM RAMATHIBODI POISON CENTER.

    PubMed

    Sriapha, Charuwan; Tongpoo, Achara; Wongvisavakorn, Sunun; Rittilert, Panee; Trakulsrichai, Satariya; Srisuma, Sahaphume; Wananukul, Winai

    2015-11-01

    Plant poisoning is not uncommon in Thailand. The objective of this study was to determine the incidence, type, clinical manifestations, severity and outcomes of plant poisoned patients in Thailand over a 10-year period. We retrospectively reviewed data from the Ramathibodi Poison Center Toxic Exposure Surveillance System for 2001-2010. A total of 2,901 poisonous plant exposure cases were identified, comprising 3.1% of the 92,392 poison cases recorded during the study period. This was the fifth most common type of poisoning recorded. Children aged < 13 years comprised the largest percent (69.8%) of the cases. The major type of exposure was unintentional ingestion. Ninety-nine types of poisonous plants were recorded as the causative agents among 99.1%of the cases. Gastrointestinal symptoms were reported in 72.0% of cases with Jatropha curcas (physic nut) comprising 54.1% of these. Most patients had only minor signs and symptoms. The mortality rate among the total plant poisoning cases was 0.9%, with 26 deaths. Thirteen deaths occurred in children aged < 13 years. The greatest number of fatalities were due to ingestion of Manihot esculenta (cassava), primarily due to multi-system organ failure. Children aged < 13 years are at the greatest risk for plant poisoning in Thailand; mostly unintentional. Most cases were minor and the mortality rate was low. Jatropha curcas was the most common cause of poisoning and Manihot esculenta was the most common cause of death. Public education is important to minimize these poisonings.

  13. PLANT POISONING IN THAILAND: A 10-YEAR ANALYSIS FROM RAMATHIBODI POISON CENTER.

    PubMed

    Sriapha, Charuwan; Tongpoo, Achara; Wongvisavakorn, Sunun; Rittilert, Panee; Trakulsrichai, Satariya; Srisuma, Sahaphume; Wananukul, Winai

    2015-11-01

    Plant poisoning is not uncommon in Thailand. The objective of this study was to determine the incidence, type, clinical manifestations, severity and outcomes of plant poisoned patients in Thailand over a 10-year period. We retrospectively reviewed data from the Ramathibodi Poison Center Toxic Exposure Surveillance System for 2001-2010. A total of 2,901 poisonous plant exposure cases were identified, comprising 3.1% of the 92,392 poison cases recorded during the study period. This was the fifth most common type of poisoning recorded. Children aged < 13 years comprised the largest percent (69.8%) of the cases. The major type of exposure was unintentional ingestion. Ninety-nine types of poisonous plants were recorded as the causative agents among 99.1%of the cases. Gastrointestinal symptoms were reported in 72.0% of cases with Jatropha curcas (physic nut) comprising 54.1% of these. Most patients had only minor signs and symptoms. The mortality rate among the total plant poisoning cases was 0.9%, with 26 deaths. Thirteen deaths occurred in children aged < 13 years. The greatest number of fatalities were due to ingestion of Manihot esculenta (cassava), primarily due to multi-system organ failure. Children aged < 13 years are at the greatest risk for plant poisoning in Thailand; mostly unintentional. Most cases were minor and the mortality rate was low. Jatropha curcas was the most common cause of poisoning and Manihot esculenta was the most common cause of death. Public education is important to minimize these poisonings. PMID:26867365

  14. Lead Poisoning in Wild Birds

    USGS Publications Warehouse

    Lahner, Lesanna L.; Franson, J. Christian

    2009-01-01

    Lead in its various forms has been used for thousands of years, originally in cooking utensils and glazes and more recently in many industrial and commercial applications. However, lead is a potent, potentially deadly toxin that damages many organs in the body and can affect all animals, including humans. By the mid 1990s, lead had been removed from many products in the United States, such as paint and fuel, but it is still commonly used in ammunition for hunting upland game birds, small mammals, and large game animals, as well as in fishing tackle. Wild birds, such as mourning doves, bald eagles, California condors, and loons, can die from the ingestion of one lead shot, bullet fragment, or sinker. According to a recent study on loon mortality, nearly half of adult loons found sick or dead during the breeding season in New England were diagnosed with confirmed or suspected lead poisoning from ingestion of lead fishing weights. Recent regulations in some states have restricted the use of lead ammunition on certain upland game hunting areas, as well as lead fishing tackle in areas frequented by common loons and trumpeter swans. A variety of alternatives to lead are available for use in hunting, shooting sports, and fishing activities.

  15. Researching nature's venoms and poisons.

    PubMed

    Warrell, David A

    2009-09-01

    Our environment hosts a vast diversity of venomous and poisonous animals and plants. Clinical toxinology is devoted to understanding, preventing and treating their effects in humans and domestic animals. In Sri Lanka, yellow oleander (Thevetia peruviana, Sinhala 'kaneru'), a widespread and accessible ornamental shrub, is a popular means of self-harm. Its toxic glycosides resemble those of foxglove, against which therapeutic antibodies have been raised. A randomised placebo-controlled trial proved that this treatment effectively reversed kaneru cardiotoxicity. There are strong scientific grounds for the use of activated charcoal, but encouraging results with multiple-dose activated charcoal were not confirmed by a recent more powerful study. Venom of Russell's viper (Daboia siamensis) in Burma (Myanmar) produces lethal effects in human victims. The case of a 17-year-old rice farmer is described with pathophysiological interpretations. During the first 9 days of hospital admission he suffered episodes of shock, coagulopathy, bleeding, acute renal failure, local tissue necrosis, generally increased capillary permeability and acute symptomatic hypoglycaemia with evidence of acute pituitary/adrenal insufficiency. Antivenom rapidly restored haemostatic function but failed to correct other effects of venom toxins incurred during the 3h before he could be treated.

  16. Acute poisoning with Tricholoma equestre.

    PubMed

    Anand, Jacek Sein; Chwaluk, Paweł; Sut, Michał

    2009-01-01

    Four cases, including three adults and one child, suffering from acute poisoning with Tricholoma equestre were described. The patients had eaten from 100 to 400 grams of the mushroom within a few consecutive meals. After consuming about 1000 grams of Tricholoma equestre for 3-4 days, the subjects developed fatigue, muscle weakness, myalgia, and in two cases acute respiratory failure with the need of respiratorotherapy. Maximal serum CK was 48136 U/L in the adults and 306 U/L in children. Maximal serum levels of AST and ALT were 802 U/L and 446 U/L in adults and 39 U/L, and 56 U/L in a child. All routine biochemical tests were within normal range. No other causes of rhabdomyolysis such as parasitic or viral infections, immune diseases, trauma or exposure to medications were found. Patient, aged 72 yrs., who developed acute respiratory failure, died in the second day of hospitalization. In other patients all the above mentioned symptoms and biochemical abnormalities disappeared from 2 to 3 weeks of hospitalization. Physicians should be aware of the possibility of appearance of rhabdo-myolysis after repeated consumption of large quantities of Tricholoma equestre. PMID:19788144

  17. Toxicological management of chlorophacinone poisoning.

    PubMed

    Lagrange, F; Corniot, A G; Titier, K; Bedry, R; Pehourcq, F

    1999-01-01

    A 33-year-old man was admitted 8 hours after voluntary ingestion of 1875 mg of chlorophacinone (C'Operat 750 mL). The examination revealed excitation and nausea, with a normal prothrombin index (PI). Comprehensive testing for abused and therapeutic drugs in blood confirmed chlorophacinone (maximum plasma level: 27.6 mg/L), an antivitamin K (AVK) rodenticide. In a search for easy toxicological management of chlorophacinone poisoning treated by phytomenadione and a cytochrome P450 inducer (phenobarbital), PI and chlorophacinone plasma levels were monitored concomitantly during 17 days. A simple HPLC procedure for the determination of chlorophacinone in human plasma is reported for that purpose. Under phenobarbital 200 mg/day, chlorophacinone exhibited an apparent elimination half-life (3.27 days) shorter than in previously reported cases. If PI is useful for planning phytomenadione treatment and used for therapeutic monitoring of AVK, the chlorophacinone concentrations follow-up may provide a better estimation of the duration of hospitalisation. Chlorophacinone accumulation in target cells or existence of an unidentified metabolite may explain persistence of the hypocoagulability syndrome at low plasmatic concentrations of chlorophacinone. This case illustrates how toxicological management may facilitate toxicokinetics and therapeutic data acquisition.

  18. Pick your poison: what's new in poison control for the preschooler.

    PubMed

    Glenn, Lauren

    2015-01-01

    Accidental childhood poisonings are a major public health concern despite many efforts to alleviate this problem. While the rate of pediatric fatalities due to poisonings have decreased over the last two decades, poison control centers around the US have collectively fielded over one million calls with regard to toxic exposures in the preschool age group. According to the American Association of Poison Control Centers nearly half of all human exposures reported last year involved children under six. By focusing poison prevention efforts on the preschooler, we can attempt to decrease morbidity and mortality in the most vulnerable age group affected. Although the subject is still prevalent, current discussion on this topic is limited. Newer literature discusses past initiatives such as child resistant packaging and sticker deterrent programs and addresses their efficacy. This article revisits older mechanisms of prevention as well as the science behind the human motivation to change one's own practice and behavior.

  19. An Unusual Cause of Carbon Monoxide Poisoning: Narghile Smoking

    PubMed Central

    Ateş, Alpay; Arikan, Müge; Özgök, Ayşegül

    2016-01-01

    Patient: Male, 27 Final Diagnosis: Carbon monoxide poisoning Symptoms: Dizziness • nausea • Syncope Medication: — Clinical Procedure: O2 treatment Specialty: Anesthesiology Objective: Challenging differential diagnosis Background: Carbon monoxide (CO) poisoning is commonly seen during the winter season in Turkey due to use of charcoal stoves and water heaters, but narghile smoking is a rare cause of CO poisoning. Case Report: In this paper, we report a CO poisoning case caused by narghile smoking. The patient was admitted to the ED with nausea, dizziness, vertigo, and syncope. Conclusions: The diagnosis of CO poisoning depends on suspicious anamnesis. The major treatment of CO poisoning is oxygen supply. PMID:27618983

  20. 75 FR 66771 - Advisory Committee on Childhood Lead Poisoning Prevention (ACCLPP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... HUMAN SERVICES Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning... lead poisoning prevention efforts. The committee also reviews and reports regularly on childhood lead poisoning prevention practices and recommends improvements in national childhood lead poisoning...

  1. An outbreak of foxglove leaf poisoning.

    PubMed

    Lin, Chun-Chi; Yang, Chen-Chang; Phua, Dong-Haur; Deng, Jou-Fang; Lu, Li-Hua

    2010-02-01

    Comfrey (Symphytum officinale) leaves resemble those of foxglove (Digitalis purpurea) when the plant is not in bloom and, therefore, cardiac glycoside poisoning may occur when people confuse foxglove with comfrey. We report an outbreak of foxglove leaf poisoning following the use of alleged "comfrey" herbal tea. Nine patients were involved and initially presented with nausea, vomiting, diarrhea and dizziness. Significant cardiotoxicity developed later among the 3 patients who also had mild hyperkalemia. Peak serum digoxin concentration measured by immunoassay was elevated in all patients and ranged from 4.4 ng/mL to 139.5 ng/mL. Patients with severe cardiotoxicity were treated with temporary cardiac pacing. Moreover, 40-80 mg of digoxin-specific antibody therapy was given without any effect. All patients recovered uneventfully. Our report highlights the potential risk of misidentification of herbs; in this case, D. purpurea was mistaken for S. officinale. Physicians should be aware that cardiac glycoside poisoning could arise from such misidentification. Public education about the toxicity of D. purpurea poisoning may reduce the risk of misidentification and subsequent poisoning. PMID:20171590

  2. Hypogonadism in chronically lead-poisoned men.

    PubMed

    Braunstein, G D; Dahlgren, J; Loriaux, D L

    1978-01-01

    The hypothalamic-pituitary-testicular axis was evaluated in 10 men with occupational lead exposure, 9 of whom had noted a decrease in libido and frequency of intercourse following this exposure. 6 of these men had clinically apparent lead poisoning while 4 were classified as being only lead-exposed. Results of the endocrine evaluation of these patients were compared to those obtained on 9 age and socioeconomically matched control patients. Both lead poisoned and lead-exposed patients had reduced basal serum testosterone levels and normal basal serum testosterone-estradiol-binding globulin capacity, estradiol, LH, FSH, and prolactin levels. Both groups demonstrated an appropriate rise in serum testosterone following hCG stimulation and a normal increment in serum FSH in response to clomiphene citrate and gonadotropin-releasing hormone in comparison to the control group. The lead poisoned patients demonstrated a significantly reduced increment in serum LH after clomiphene citrate and gonadotropin-releasing hormone administration while the lead-exposed patients had normal LH dynamics. Testicular biopsies carried out on the 2 most severely lead-poisoned men showed peritubular fibrosis, oligospermia, and vacuolization of the Sertoli cells. These results suggest that lead poisoning may lead to a pituitary-hypothalamic defect in LH secretion and may also result in direct testicular seminiferous tubular injury.

  3. Nicotine replacement products: poisoning in children.

    PubMed

    2014-05-01

    Nicotine is widely used in smoking cessation aids. They are marketed in many forms, including: chewing gum, sublingual tablets, lozenges, transdermal patches, cartridges for oral inhalation, and mouth spray. French poison control and toxico-vigilance centres identified 318 cases of exposure to nicotine replacement products in children under the age of 10 years between 2000 and 2010. The exposure provoked symptoms in 62 of these children, about two-thirds of whom were under the age of 4 years. A U.S. analysis identified 1768 cases of poisoning in children under the age of 6 years involving smokeless tobacco products, reported between 2006 and 2008.84% of these cases occurred in children under the age of 3 years. The first signs of nicotine poisoning are gastrointestinal (vomiting, diarrhoea), cardiovascular (tachycardia, hypertension) and neuropsychological (tremor of the extremities). With higher doses, these effects are rapidly followed by loss of consciousness, convulsions or respiratory failure. In children, poisoning can occur after ingestion of 1 mg of nicotine per kilogram of body weight. A dose of this magnitude is sometimes fatal in adults. Most cases of poisoning involving transdermal patches occur when a child finds an unused patch, or a used patch that an adult has discarded in a bin without taking proper precautions. Sometimes they involve patches that have become detached from an adult's skin. In practice, it is important to warn adults using smoking cessation aids containing nicotine that these products are dangerous

  4. Possible role for anisodamine in organophosphate poisoning.

    PubMed

    Eisenkraft, Arik; Falk, Avshalom

    2016-06-01

    In cases of organophosphate poisoning, patients are treated with a combination of antidotes. In addition to these poison-directed antidotes, patients may require extra oxygen and artificial ventilation; other modalities may also be needed due to the wide range of toxic effects. Anisodamine is a belladonna alkaloid, and like other drugs from this family is non subtype-selective muscarinic, and a nicotinic cholinoceptor antagonist, which has been employed in traditional Chinese medicine. As a muscarinic antagonist, it displays similar pharmacological effects to atropine and scopolamine. However, anisodamine is not only less potent than atropine and scopolamine but also less toxic. Current in vitro and animal model studies have demonstrated that anisodamine has protective effects in a variety of diseases. Organophosphate poisoning involves not only the central and peripheral nervous systems, but also the cardiac and respiratory systems, as well as activation of inflammatory processes and oxidative stress. Therefore, the anticholinergic and additional activities of anisodamine appear to be relevant and justify its consideration as an addition to the existing remedies. However, more research is needed, as at present data on the role of anisodamine in the management of organophosphate poisoning are limited. Here, we review the beneficial effects of anisodamine on processes relevant to organophosphate poisoning.

  5. Pancreatitis in wild zinc-poisoned waterfowl

    USGS Publications Warehouse

    Sileo, Louis; Beyer, W. Nelson; Mateo, Rafael

    2003-01-01

    Four waterfowl were collected in the TriState Mining District (Oklahoma, Kansas and Missouri, USA), an area known to be contaminated with lead, cadmium and zinc (Zn). They were part of a larger group of 20 waterfowl collected to determine the exposure of birds to metal contamination at the site. The four waterfowl (three Branta canadensis, one Anas platyrhynchos) had mild to severe degenerative abnormalities of the exocrine pancreas, as well as tissue (pancreas, liver) concentrations of Zn that were considered toxic. The mildest condition was characterized by generalized atrophy of exocrine cells that exhibited cytoplasmic vacuoles and a relative lack of zymogen. The most severe condition was characterized by acini with distended lumens and hyperplastic exocrine tissue that completely lacked zymogen; these acini were widely separated by immature fibrous tissue. Because the lesions were nearly identical to the lesions reported in chickens and captive waterfowl that had been poisoned with ingested Zn, and because the concentrations of Zn in the pancreas and liver of the four birds were consistent with the concentrations measured in Zn-poisoned birds, we concluded that these waterfowl were poisoned by Zn. This may be the first reported case of zinc poisoning in free-ranging wild birds poisoned by environmental Zn.

  6. Hypotension in Severe Dimethoate Self-Poisoning

    PubMed Central

    Davies, James; Roberts, Darren; Eyer, Peter; Buckley, Nick; Eddleston, Michael

    2008-01-01

    Introduction Acute self-poisoning with the organophosphorus (OP) pesticide dimethoate has a human case fatality three-fold higher than poisoning with chlorpyrifos despite similar animal toxicity. The typical clinical presentation of severe dimethoate poisoning is quite distinct from that of chlorpyrifos and other OP pesticides: many patients present with hypotension that progresses to shock and death within 12–48 h post-ingestion. The pathophysiology of this syndrome is not clear. Case reports We present here three patients with proven severe dimethoate poisoning. Clinically, all had inappropriate peripheral vasodilatation and profound hypotension on presentation, which progressed despite treatment with atropine, i.v. fluids, pralidoxime chloride, and inotropes. All died 2.5–32 h post-admission. Continuous cardiac monitoring and quantification of troponin T provided little evidence for a primary cardiotoxic effect of dimethoate. Conclusion Severe dimethoate self-poisoning causes a syndrome characterized by marked hypotension with progression to distributive shock and death despite standard treatments. A lack of cardiotoxicity until just before death suggests that the mechanism is of OP-induced low systemic vascular resistance (SVR). Further invasive studies of cardiac function and SVR, and post-mortem histology, are required to better describe this syndrome and to establish the role of vasopressors and high-dose atropine in therapy. PMID:19003596

  7. Outline of occupational chromium poisoning in China.

    PubMed

    Yang, Yuan; Liu, Hong; Xiang, Xian-hong; Liu, Fu-you

    2013-06-01

    The present study analyzed the feature of occupational chromium poisoning in China since the 1980s. The collected data were acquired from 18 previous surveys of chromium poisoning in 14 cities of China. The method of risk assessment was applied to calculate the relative risk and 95% CI, p < 0.05 was considered as a significant risk. The results showed that nasal disease was the most common sign of occupational chromium poisoning, and the prevalence rate of nasal disease was 17.83% in total population of 6,998. Further, the risk analysis showed that occupational chromium poisoning led to an increased risk of lung or liver cancer in male workers due to the definite carcinogenicity of hexavalent chromium. Significantly, an increased risk of spontaneous or threatened abortion was also found in female workers. In conclusion, these studies suggest that early detection of impaired reproductive function or impaired lung or liver function in female or male workers is essential for controlling occupational chromium poisoning in China. PMID:23604023

  8. An accidental poisoning with mitragynine.

    PubMed

    Karinen, Ritva; Fosen, Jan Toralf; Rogde, Sidsel; Vindenes, Vigdis

    2014-12-01

    An increasing number of drugs of abuse are sold word wide over the internet. Names like "legal highs", "herbal highs" etc. give the impression that these are safe products, although the risk of fatal reactions might be substantial. Leaves from the plant Mitragyna speciosa, contain active compounds like mitragynine and 7-hydroxymitragynine. It has been reported that the potency of 7-hydroxymitragynine at the μ-opioid receptor is 30 times higher than that of mitragynine and 17 times higher than that of morphine. Case reports regarding poisoning with Kratom are reported, but the toxic or lethal ranges for the concentrations of the active substances have not been established, and concentrations of 7-hydroxymitragynine have not been reported previously. We present a case report where a middle aged man was found dead at home. The deceased had a history of drug abuse and mental illness for several years. At autopsy, there were no significant pathological findings. Post-mortem analysis of peripheral blood revealed: zopiclone 0.043mg/L, citalopram 0.36mg/L and lamotrigine 5.4mg/L, i.e. concentrations regularly seen after therapeutic ingestion of these drugs. Additionally mitragynine 1.06mg/L and 7-hydroxymitragynine 0.15mg/L were detected in blood and both also in urine. The high concentrations of mitragynine and 7-hydroxymitragynine indicate that the cause of death is intoxication by these substances; and the circumstances point toward the manner of death being accidental. We recommend that both mitragynine and 7-hydroxymitragynine are analyzed for in cases with suspected Kratom intoxication. PMID:25453780

  9. Fatal pediatric poisoning from leaded paint--Wisconsin, 1990

    SciTech Connect

    Not Available

    1991-03-29

    Although fatal lead poisoning among children occurs rarely in the United States, it represents a medical and public health emergency. This report summarizes the investigation of a child who died from poisoning associated with ingestion of lead-based paint.

  10. [The most popular poisons from Graeco-Roman world].

    PubMed

    Siek, Bartlomiej; Rys, Anna; Sein Anand, Jacek

    2013-01-01

    Article presents the most popular antique poisons. Information from encyclopaedic literature and literary texts of the Roman Empire period has been compared with the etymology of the names of some poisons of plant and animal origin.

  11. 77 FR 64997 - Advisory Committee on Childhood Lead Poisoning Prevention

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... HUMAN SERVICES Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning... scientific knowledge and technological developments and their practical implications for childhood lead poisoning prevention efforts. The committee also reviews and reports regularly on childhood lead...

  12. The essential role of a poison center in handling an outbreak of barium carbonate poisoning.

    PubMed

    Deng, J F; Jan, I S; Cheng, H S

    1991-04-01

    Acute barium salt poisoning may cause acute hypokalemia and result in respiratory paralysis and ventricular tachyarrhythmias. The early nonspecific gastrointestinal symptoms of barium poisoning due to food contamination could be confused with other benign food poisonings. Early diagnosis and initiation of intensive supportive care is essential. We report an outbreak of acute barium carbonate poisoning, occurring at a family reunion party, which resulted in 9 hospital admissions. All of the victims initially developed nausea, vomiting, abdominal colic, dizziness and watery diarrhea followed by numbness of the face and distal extremities 1-2 h after ingesting fried flour-coated sweet potatoes. The flour was later confirmed to be contaminated with barium carbonate. One person died in the emergency room with a serum potassium level of 0.8 mEq/L. Two other victims developed ventricular tachycardia and respiratory paralysis but completely recovered with the treatment advice provided by the poison center. The poison center was successful in helping to make the correct diagnosis in a timely manner, immediately distribute the treatment protocol, and coordinate the laboratory confirmation of barium carbonate poisoning.

  13. Zebrafish Models for Human Acute Organophosphorus Poisoning.

    PubMed

    Faria, Melissa; Garcia-Reyero, Natàlia; Padrós, Francesc; Babin, Patrick J; Sebastián, David; Cachot, Jérôme; Prats, Eva; Arick Ii, Mark; Rial, Eduardo; Knoll-Gellida, Anja; Mathieu, Guilaine; Le Bihanic, Florane; Escalon, B Lynn; Zorzano, Antonio; Soares, Amadeu M V M; Raldúa, Demetrio

    2015-10-22

    Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning.

  14. A review of lead poisoning in swans

    USGS Publications Warehouse

    Blus, L.J.

    1994-01-01

    Nearly 10,000 swans of six species or subspecies from 14 countries have died from poisoning caused by lead that originated from ingestion of fishing weights, shotgun pellets (shot), or contaminated vegetation or sediments associated with mining and smelting wastes. Lead contamination in mute swans in England caused local population declines during the late 1970s and 1980s. More tundra swans died from lead poisoning than any other species. The extreme record involved an estimated 7200 tundra swans that died over five winters at one locality in North Carolina. The recent legislation to ban lead fishing weights in most of England and Wales and recent replacement of lead shot with steel shot for waterfowl hunting in the United States and a few areas of Europe, including Denmark, are expected to reduce the incidence of lead poisoning in swans.

  15. Poisoned after Dinner: Dolma with Datura Stramonium.

    PubMed

    Disel, Nezihat Rana; Yilmaz, Mustafa; Kekec, Zeynep; Karanlik, Meryem

    2015-03-01

    Datura stramonium, which is also known as Thorn Apple or Jimson Weed, is an alkaloid containing plant that is entirely toxic. The active toxic constituents of the plant are atropine, scopolamine and hyoscyamine. It has been abused worldwide for hundreds of years because of its hallucinogenic properties. Previous reports have shown that herbal medication overdose and accidental food contamination are ways it can cause poisoning. Herein we present a family that had three of its members poisoned after eating a traditional meal "dolma" made of datura flowers. None had fatal complications and all were discharged healthy. Datura stromonium may be used accidentally as a food ingredient. Since its poisonous effects are not known, people should be informed and warned about the effects of this plant. PMID:27437523

  16. Zebrafish Models for Human Acute Organophosphorus Poisoning.

    PubMed

    Faria, Melissa; Garcia-Reyero, Natàlia; Padrós, Francesc; Babin, Patrick J; Sebastián, David; Cachot, Jérôme; Prats, Eva; Arick Ii, Mark; Rial, Eduardo; Knoll-Gellida, Anja; Mathieu, Guilaine; Le Bihanic, Florane; Escalon, B Lynn; Zorzano, Antonio; Soares, Amadeu M V M; Raldúa, Demetrio

    2015-01-01

    Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning. PMID:26489395

  17. Iguana bites reported to Texas poison centers.

    PubMed

    Forrester, Mathias B

    2010-09-01

    Although thousands of iguanas are kept as pets in the United States, information on their bites is limited. The intent of this investigation was to describe the pattern of iguana bites reported to Texas poison centers. Iguana bites reported during 1998-2008 were identified. The distribution of cases by various factors was determined. Of 59 total bites, 71% were managed on-site, 17% of the patients were at or en route to a health care facility when the poison center was contacted, and 10% were referred to a health care facility. The medical outcome was no effect in 9% of the cases, minor effect in 24%, moderate effect in 2%, not followed but minimal effects possible in 64%, and unable to follow but potentially toxic in 2%. Most iguana bites reported to Texas poison centers did not result in serious effects and were managed on-site.

  18. Fatal parathion poisoning in Sierra Leone

    PubMed Central

    Etzel, R. A.; Forthal, D. N.; Hill, R. H.; Demby, A.

    1987-01-01

    In May and June 1986, 49 persons in Sierra Leone were acutely poisoned by the organothiophosphate insecticide, parathion. Fourteen people died. Illness occurred in three episodes at two different locations that were 44 km apart. A study of 21 cases and 22 household controls was undertaken to explore which factors were associated with the development of the symptoms. Cases were more likely than controls to have eaten bread in the 4 hours before becoming ill (odds ratio, 12.7; 95% confidence interval, 2.4-83.8). Scrapings of residue from the floor of the truck that had brought the wheat flour from the mill to the general store where the baker purchased it were positive for parathion, suggesting that the flour had been contaminated during transport. Pesticide poisoning is a common problem in the developing world, and public health measures such as restricting the use of parathion may help to prevent fatal poisonings. PMID:3501344

  19. Zebrafish Models for Human Acute Organophosphorus Poisoning

    PubMed Central

    Faria, Melissa; Garcia-Reyero, Natàlia; Padrós, Francesc; Babin, Patrick J.; Sebastián, David; Cachot, Jérôme; Prats, Eva; Arick II, Mark; Rial, Eduardo; Knoll-Gellida, Anja; Mathieu, Guilaine; Le Bihanic, Florane; Escalon, B. Lynn; Zorzano, Antonio; Soares, Amadeu M.V.M; Raldúa, Demetrio

    2015-01-01

    Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning. PMID:26489395

  20. From the battlefields to the states: the road to recovery. The role of Landstuhl Regional Medical Center in US military casualty care.

    PubMed

    Tenuta, Joachim J

    2006-01-01

    The transformation of the modern battlefield with respect to weaponry, modes of transportation, enemy capabilities and location, as well as technological advances, has greatly altered the tactical approach to the mission. Combat casualty care must continually evolve in response to the differences in types of injury, the number and triage of casualties, timing of treatment, and location of care. These battlefield changes have been demonstrated on a large scale in the global war on terrorism, which includes the military operations in Afghanistan and Iraq. The medical response has kept pace with this 21st-century conflict. Even in the new environment of armed conflict and with the advent of new technologies, the principles of managing orthopaedic combat casualties remain clear: preservation of life and limb, skeletal stabilization, and aggressive wound débridement. For United States service members wounded in the current conflicts, Landstuhl Regional Medical Center is a crucial stop along the road to recovery. PMID:17003206

  1. Using Poison Center Data for Postdisaster Surveillance

    PubMed Central

    Wolkin, Amy; Schnall, Amy H.; Law, Royal; Schier, Joshua

    2015-01-01

    The role of public health surveillance in disaster response continues to expand as timely, accurate information is needed to mitigate the impact of disasters. Health surveillance after a disaster involves the rapid assessment of the distribution and determinants of disaster-related deaths, illnesses, and injuries in the affected population. Public health disaster surveillance is one mechanism that can provide information to identify health problems faced by the affected population, establish priorities for decision makers, and target interventions to meet specific needs. Public health surveillance traditionally relies on a wide variety of data sources and methods. Poison center (PC) data can serve as data sources of chemical exposures and poisonings during a disaster. In the US, a system of 57 regional PCs serves the entire population. Poison centers respond to poison-related questions from the public, health care professionals, and public health agencies. The Centers for Disease Control and Prevention (CDC) uses PC data during disasters for surveillance of disaster-related toxic exposures and associated illnesses to enhance situational awareness during disaster response and recovery. Poison center data can also be leveraged during a disaster by local and state public health to supplement existing surveillance systems. Augmenting traditional surveillance data (ie, emergency room visits and death records) with other data sources, such as PCs, allows for better characterization of disaster-related morbidity and mortality. Poison center data can be used during a disaster to detect outbreaks, monitor trends, track particular exposures, and characterize the epidemiology of the event. This timely and accurate information can be used to inform public health decision making during a disaster and mitigate future disaster-related morbidity and mortality. PMID:25205009

  2. Levothyroxine Poisoning - Symptoms and Clinical Outcome.

    PubMed

    Nygaard, Birgitte; Saedder, Eva A; Dalhoff, Kim; Wikkelsoe, Mette; Jürgens, Gesche

    2015-10-01

    Levothyroxine (LT), T4, poisoning is rarely associated with a severe outcome. However, cases with significant complications have been reported. The aim of this study was to identify factors associated with symptoms of poisoning including late-onset symptoms. All enquiries to the Danish Poison Information Centre (DPIC) concerning LT poisoning between March 2007 and September 2012 were reviewed and the following parameters were recorded: age, dose, time from ingestion, multiple drug intake and symptoms. To evaluate the frequency of late-onset symptoms, a subgroup of patients without initial symptoms were contacted. A total of 181 patients were registered (112 children). Ingested LT dose ranged from 10 to 9000 mcg (median 275 mcg). A total of 29 of 181 (16%) patients were symptomatic at the time of enquiry, and there was no difference in ingested LT dose between asymptomatic and symptomatic patients, neither in children nor in adults (age 16-92 years) (p < 0.68 and p < 0.47, respectively). In total, 153 of 181 (85%) patients did not have symptoms of poisoning at the time of enquiry; however, in 9 of 21 (43%) patients, we were able to contact, late-onset symptoms existed. In none of the cases, hospital contact was needed and there were no reports of long-term sequelae. Acute LT poisoning often follows a benign course. The occurrence of symptoms appears not to be dose dependent. Late-onset symptoms seem to be common. However, all symptoms resolved spontaneously without need of medical care.

  3. Management of acute organophosphorus pesticide poisoning

    PubMed Central

    Eddleston, Michael; Buckley, Nick A; Eyer, Peter; Dawson, Andrew H

    2008-01-01

    Summary Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000 people every year. Unintentional poisoning kills far fewer people but is a problem in places where highly toxic organophosphorus pesticides are available. Medical management is difficult, with case fatality generally more than 15%. We describe the limited evidence that can guide therapy and the factors that should be considered when designing further clinical studies. 50 years after first use, we still do not know how the core treatments—atropine, oximes, and diazepam—should best be given. Important constraints in the collection of useful data have included the late recognition of great variability in activity and action of the individual pesticides, and the care needed cholinesterase assays for results to be comparable between studies. However, consensus suggests that early resuscitation with atropine, oxygen, respiratory support, and fluids is needed to improve oxygen delivery to tissues. The role of oximes is not completely clear; they might benefit only patients poisoned by specific pesticides or patients with moderate poisoning. Small studies suggest benefit from new treatments such as magnesium sulphate, but much larger trials are needed. Gastric lavage could have a role but should only be undertaken once the patient is stable. Randomised controlled trials are underway in rural Asia to assess the effectiveness of these therapies. However, some organophosphorus pesticides might prove very difficult to treat with current therapies, such that bans on particular pesticides could be the only method to substantially reduce the case fatality after poisoning. Improved medical management of organophosphorus poisoning should result in a reduction in worldwide deaths from suicide. PMID:17706760

  4. The poisonous rocks of Kärkevagge

    NASA Astrophysics Data System (ADS)

    Darmody, R. G.; Allen, C. E.; Thorn, C. E.; Dixon, J. C.

    2001-11-01

    The black schist in Kärkevagge, Swedish Lapland has been reported to weather easily and produce a poisonous effect on vegetation. This research was an investigation of that phenomenon as part of a larger study of weathering in Kärkevagge. In July 1999, soil and plant samples were collected downslope of a "poisonous" boulder. Samples from the adjacent unaffected slope served as references. Biomass, plant elemental composition, and soil fertility were determined. Most plants within 1.4 m downslope of the poison boulder were dead, and effects on plant growth could be seen to about 6 m. Plants near the boulder had elevated levels of K, B, Al, Cd, Se, and Fe, and lower levels of Ca, Mn, and Ba compared to reference plants. In the soil near the poison boulder, extractable S, Cd, and Fe and salt contents were greater, while pH and extractable Cl, P, Ca, Mg, K, Ba, Ni, and Cr were lower than in the reference soil. At 10 m downslope of the boulder, soil and plant chemistry was more similar to the reference materials, but some effects were still noted. Elemental analyses of the poison boulder and soil revealed no particular plant toxins, although contents of Fe and S were higher and Ca lower than in reference materials. We believe the poison is sulfuric acid, which forms as a consequence of pyrite oxidation. The dark color of the boulder is consistent with a pyrite-bearing lithology and other field observations and laboratory analyses support the hypothesis. Coatings on local rocks include jarosite, gypsum, and copiapite, secondary minerals associated with pyrite oxidation and weathering accelerated by sulfuric acid. Radiocarbon dating indicates that the rock fell off the cliff some time before 245 14C years BP.

  5. Using poison center data for postdisaster surveillance.

    PubMed

    Wolkin, Amy; Schnall, Amy H; Law, Royal; Schier, Joshua

    2014-10-01

    The role of public health surveillance in disaster response continues to expand as timely, accurate information is needed to mitigate the impact of disasters. Health surveillance after a disaster involves the rapid assessment of the distribution and determinants of disaster-related deaths, illnesses, and injuries in the affected population. Public health disaster surveillance is one mechanism that can provide information to identify health problems faced by the affected population, establish priorities for decision makers, and target interventions to meet specific needs. Public health surveillance traditionally relies on a wide variety of data sources and methods. Poison center (PC) data can serve as data sources of chemical exposures and poisonings during a disaster. In the US, a system of 57 regional PCs serves the entire population. Poison centers respond to poison-related questions from the public, health care professionals, and public health agencies. The Centers for Disease Control and Prevention (CDC) uses PC data during disasters for surveillance of disaster-related toxic exposures and associated illnesses to enhance situational awareness during disaster response and recovery. Poison center data can also be leveraged during a disaster by local and state public health to supplement existing surveillance systems. Augmenting traditional surveillance data (ie, emergency room visits and death records) with other data sources, such as PCs, allows for better characterization of disaster-related morbidity and mortality. Poison center data can be used during a disaster to detect outbreaks, monitor trends, track particular exposures, and characterize the epidemiology of the event. This timely and accurate information can be used to inform public health decision making during a disaster and mitigate future disaster-related morbidity and mortality.

  6. Prognostic Factors in Cholinesterase Inhibitor Poisoning

    PubMed Central

    Sun, In O; Yoon, Hyun Ju; Lee, Kwang Young

    2015-01-01

    Background Organophosphates and carbamates are insecticides that are associated with high human mortality. The purpose of this study is to investigate the prognostic factors affecting survival in patients with cholinesterase inhibitor (CI) poisoning. Material/Methods This study included 92 patients with CI poisoning in the period from January 2005 to August 2013. We divided these patients into 2 groups (survivors vs. non-survivors), compared their clinical characteristics, and analyzed the predictors of survival. Results The mean age of the included patients was 56 years (range, 16–88). The patients included 57 (62%) men and 35 (38%) women. When we compared clinical characteristics between the survivor group (n=81, 88%) and non-survivor group (n=11, 12%), there were no differences in renal function, pancreatic enzymes, or serum cholinesterase level, except for serum bicarbonate level and APACHE II score. The serum bicarbonate level was lower in non-survivors than in survivors (12.45±2.84 vs. 18.36±4.73, P<0.01). The serum APACHE II score was higher in non-survivors than in survivors (24.36±5.22 vs. 12.07±6.67, P<0.01). The development of pneumonia during hospitalization was higher in non-survivors than in survivors (n=9, 82% vs. n=31, 38%, P<0.01). In multiple logistic regression analysis, serum bicarbonate concentration, APACHE II score, and pneumonia during hospitalization were the important prognostic factors in patients with CI poisoning. Conclusions Serum bicarbonate and APACHE II score are useful prognostic factors in patients with CI poisoning. Furthermore, pneumonia during hospitalization was also important in predicting prognosis in patients with CI poisoning. Therefore, prevention and active treatment of pneumonia is important in the management of patients with CI poisoning. PMID:26411989

  7. Hematologic effects of heavy metal poisoning.

    PubMed

    Ringenberg, Q S; Doll, D C; Patterson, W P; Perry, M C; Yarbro, J W

    1988-09-01

    Heavy metal poisoning can cause a variety of hematologic disorders. Exposure to heavy metals is ubiquitous in the industrial environment and must be considered in the differential diagnosis of many types of anemia. The heavy metals most commonly associated with hematologic toxicity are arsenic and its derivative arsine, copper, gold, lead, and zinc. A few distinctive clinical features characterize the hematologic manifestations of many occult heavy metal poisonings. These features have a limited differential diagnosis. A knowledge of these clinical features can assist the astute clinician in making the correct diagnosis.

  8. Paralytic Shellfish Poisoning: A Case Series

    PubMed Central

    Hurley, William; Wolterstorff, Cameron; MacDonald, Ryan; Schultz, Debora

    2014-01-01

    We describe a case series of seven patients presenting to an emergency department with symptoms of paralytic shellfish poisoning. They developed varying degrees of nausea, vomiting, diarrhea, weakness, ataxia and paresthesias after eating mussels harvested from a beach near their resort. Four patients were admitted to the hospital, one due to increasing respiratory failure requiring endotracheal intubation and the remainder for respiratory monitoring. All patients made a full recovery, most within 24 hours. The ability to recognize and identify paralytic shellfish poisoning and manage its complications are important to providers of emergency medicine. PMID:25035737

  9. Pharmacologic Strategies for Treatment of Poisonings.

    PubMed

    Roberts, Eric; Gooch, Michael D

    2016-03-01

    Poisoning is the leading cause of injury-related mortality in the United States. Data suggest that nonmedical use of pharmaceuticals is increasing, along with a proportional increase in subsequent adverse events. The widespread use of illegal drugs contributes to the challenge, because these drugs may produce a wide array of clinical presentations that warrant time-critical recognition and treatment. Common legal and illegal poisonings highlighting clinical presentations in terms of toxidromes as a means of categorically recognizing these emergencies is the focus of this article. To optimize outcomes for situations such as these, pharmacologic considerations are discussed and explored. PMID:26897424

  10. Important poisonous plants in tibetan ethnomedicine.

    PubMed

    Ma, Lijuan; Gu, Ronghui; Tang, Li; Chen, Ze-E; Di, Rong; Long, Chunlin

    2015-01-01

    Tibetan ethnomedicine is famous worldwide, both for its high effectiveness and unique cultural background. Many poisonous plants have been widely used to treat disorders in the Tibetan medicinal system. In the present review article, some representative poisonous plant species are introduced in terms of their significance in traditional Tibetan medicinal practices. They are Aconitum pendulum, Strychnos nux-vomica, Datura stramonium and Anisodus tanguticus, for which the toxic chemical constituents, bioactivities and pharmacological functions are reviewed herein. The most important toxins include aconitine, strychnine, scopolamine, and anisodamine. These toxic plants are still currently in use for pain-reduction and other purposes by Tibetan healers after processing. PMID:25594733

  11. Ciguatera-like poisoning in the Mediterranean.

    PubMed

    Raikhlin-Eisenkraft, B; Finkelstein, Y; Spanier, E

    1988-12-01

    A case of group poisoning from the consumption of the fish Sarpa salpa, caught in the Mediterranean coastal waters of Israel, is presented. Mullets and rabbitfish caught at the same site caused no harm. This is the third case of ciguatera poisoning in the region and the first to be transferred by a fish which is not a Red Sea immigrant. It implies that toxic algae dinoflagellates, originating from the Red Sea, crossed the Suez Canal and found their way to the Mediterranean coastal waters.

  12. ["Junk-food"-intervention in poisoning delusion].

    PubMed

    Schwerthöffer, Dirk; Bäuml, Josef

    2007-11-01

    Case report about a 29-year old US-American patient who suddenly flew to Germany due to a schizoaffektive disorder. During a stay in our psychiatric hospital she refused food, liquid and medication because of fear of being poisoned. After four days her general condition had worsened rapidly so that parenteral nutrition was discussed. Surprisingly her poisoning delusion could be overcome by offering American "Junk-Food". From this moment on compliance in taking of medication improved too, so that renormalisation of her condition was achieved. PMID:17160755

  13. Important Poisonous Plants in Tibetan Ethnomedicine

    PubMed Central

    Ma, Lijuan; Gu, Ronghui; Tang, Li; Chen, Ze-E; Di, Rong; Long, Chunlin

    2015-01-01

    Tibetan ethnomedicine is famous worldwide, both for its high effectiveness and unique cultural background. Many poisonous plants have been widely used to treat disorders in the Tibetan medicinal system. In the present review article, some representative poisonous plant species are introduced in terms of their significance in traditional Tibetan medicinal practices. They are Aconitum pendulum, Strychnos nux-vomica, Datura stramonium and Anisodus tanguticus, for which the toxic chemical constituents, bioactivities and pharmacological functions are reviewed herein. The most important toxins include aconitine, strychnine, scopolamine, and anisodamine. These toxic plants are still currently in use for pain-reduction and other purposes by Tibetan healers after processing. PMID:25594733

  14. [Venomous and poisonous animals--I. Overview].

    PubMed

    Chippaux, J P; Goyffon, M

    2006-06-01

    Venomous animals that are able to innoculate or inject venom and poisonous animals that cannot inject venom but are toxic when ingested belong to all zoological groups. They can be encountered worldwide in any ecosystem on land and at sea but they are more common and more dangerous in tropical areas. This first article of a series to appear in the next issues of Medecine Tropicale presents an overview of species involved in envenomations and poisonings. In addition to a brief reviewing geographic risks and circumstances in which bites, stings or ingestion occur, some information is provided about antivenim therapy, the only etiological treatment.

  15. Important poisonous plants in tibetan ethnomedicine.

    PubMed

    Ma, Lijuan; Gu, Ronghui; Tang, Li; Chen, Ze-E; Di, Rong; Long, Chunlin

    2015-01-14

    Tibetan ethnomedicine is famous worldwide, both for its high effectiveness and unique cultural background. Many poisonous plants have been widely used to treat disorders in the Tibetan medicinal system. In the present review article, some representative poisonous plant species are introduced in terms of their significance in traditional Tibetan medicinal practices. They are Aconitum pendulum, Strychnos nux-vomica, Datura stramonium and Anisodus tanguticus, for which the toxic chemical constituents, bioactivities and pharmacological functions are reviewed herein. The most important toxins include aconitine, strychnine, scopolamine, and anisodamine. These toxic plants are still currently in use for pain-reduction and other purposes by Tibetan healers after processing.

  16. [The viper--Finland's only poisonous snake].

    PubMed

    Vuori, Arno

    2011-01-01

    The viper (Vipera berus) is the most common poisonous snake in Europe, and the only one in Finland. In viper bites, highly varying amounts of venom end up into the victim, whereby prediction of the progression of symptoms of poisoning is very difficult. A severe clinical picture must always be anticipated. The size of the victim has also an effect on the outcome. Adequate monitoring and when necessary, massive fluid therapy are essential in the treatment. Due to possible kidney damage, anti-inflammatory drugs are not recommended. Severe or rapidly progressing symptoms require the use of an antidote.

  17. [Recommendations for the prevention of poisoning].

    PubMed

    Mintegi, S; Esparza, M J; González, J C; Rubio, B; Sánchez, F; Vila, J J; Yagüe, F; Benítez, M T

    2015-12-01

    Poisoning is the fifth leading cause of death from unintentional injury in the WHO European region, while Spain is in the group with a lower rate. Most involuntary poisonings occur in young children while they are at the home, due to unintentional ingestion of therapeutic drugs or household products. Of these, a large percentage is stored in non-original containers and/or within reach of children. In this article, the Committee on Safety and Non-Intentional Injury Prevention in Childhood of the Spanish Association of Pediatrics provides a series of recommendations, educational as well as legal, to prevent such cases.

  18. 21 CFR 509.6 - Added poisonous or deleterious substances.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Added poisonous or deleterious substances. 509.6...-PACKAGING MATERIAL General Provisions § 509.6 Added poisonous or deleterious substances. (a) Use of an added... approved under the criteria of section 409 of the act, or when the added poisonous or deleterious...

  19. Gastrolobium spp. poisoning in sheep: A case report

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This report describes the history and investigation of a suspected plant poisoning event in Western Australia where fifteen sheep died. One of the poisoned sheep was necropsied and gross and microscopic pathology of the poisoned sheep is described. Monofluoroacetate was detected in rumen contents ...

  20. Childhood Lead Poisoning: A Disease for the History Texts.

    ERIC Educational Resources Information Center

    Needleman, Herbert L.

    1991-01-01

    Discusses the mounting evidence for the neurological damage of childhood lead poisoning. Argues that ignoring lead poisoning is more expensive than preventing it. Reviews a recent plan to eradicate lead poisoning and the sociological factors that may impede its implementation. (CJS)

  1. Statistics and Epidemiology of Lead Poisoning (FY 72-L1).

    ERIC Educational Resources Information Center

    Morrison, John H., Jr.; And Others

    This report is the first in a quarterly series which will contain statistics and epidemiologic notes on lead poisoning at both the national and local levels. This report contains (a) statistics on childhood lead poisoning; (b) a status report on the Community Lead Poisoning Data System, which was designed to assist local lead control programs and…

  2. Childhood Lead Poisoning. Rhode Island KIDS COUNT Issue Brief.

    ERIC Educational Resources Information Center

    Harrington, Ann-Marie, Ed.; Walsh, Catherine Boisvert, Ed.; Bryant, Elizabeth Burke, Ed.

    1997-01-01

    One of the most common pediatric health problems is childhood lead poisoning. This report examines the preventable problem of lead poisoning. The report describes childhood lead poisoning as both a health problem to which infants and young children are most susceptible, and as a housing problem. More than half the housing units in Rhode Island…

  3. Childhood Lead Poisoning: Developing Prevention Programs and Mobilizing Resources.

    ERIC Educational Resources Information Center

    Rochow, K. W. James

    The current approach to dealing with childhood lead poisoning has led to repeated diagnoses of poisoning because such children are treated and then returned to their hazardous environments. This handbook describes in detail the program requirements for effective childhood lead poisoning prevention programs at the local level based on the…

  4. Fight Homemade Poisons: Home Food Care and Preservation.

    ERIC Educational Resources Information Center

    Keller, Rosanne

    One of a series of instructional materials produced by the Literacy Council of Alaska, this booklet provides information about food poisoning. Using a simplified vocabulary and shorter sentences, it explains the various kinds of food poisoning, how people get food poisoning, and how to prevent it. (FL)

  5. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  6. 14 CFR 137.39 - Economic poison dispensing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Economic poison dispensing. 137.39 Section... AIRCRAFT OPERATIONS Operating Rules § 137.39 Economic poison dispensing. (a) Except as provided in... economic poison that is registered with the U.S. Department of Agriculture under the Federal...

  7. 14 CFR 137.39 - Economic poison dispensing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Economic poison dispensing. 137.39 Section... AIRCRAFT OPERATIONS Operating Rules § 137.39 Economic poison dispensing. (a) Except as provided in... economic poison that is registered with the U.S. Department of Agriculture under the Federal...

  8. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  9. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  10. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  11. 49 CFR 172.555 - POISON INHALATION HAZARD placard.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false POISON INHALATION HAZARD placard. 172.555 Section... REQUIREMENTS, AND SECURITY PLANS Placarding § 172.555 POISON INHALATION HAZARD placard. (a) Except for size and color, the POISON INHALATION HAZARD placard must be as follows: ER22JY97.025 (b) In addition...

  12. 14 CFR 137.39 - Economic poison dispensing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Economic poison dispensing. 137.39 Section... AIRCRAFT OPERATIONS Operating Rules § 137.39 Economic poison dispensing. (a) Except as provided in... economic poison that is registered with the U.S. Department of Agriculture under the Federal...

  13. 14 CFR 137.39 - Economic poison dispensing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Economic poison dispensing. 137.39 Section... AIRCRAFT OPERATIONS Operating Rules § 137.39 Economic poison dispensing. (a) Except as provided in... economic poison that is registered with the U.S. Department of Agriculture under the Federal...

  14. 49 CFR 172.555 - POISON INHALATION HAZARD placard.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON INHALATION HAZARD placard. 172.555 Section... REQUIREMENTS, AND SECURITY PLANS Placarding § 172.555 POISON INHALATION HAZARD placard. (a) Except for size and color, the POISON INHALATION HAZARD placard must be as follows: ER22JY97.025 (b) In addition...

  15. 49 CFR 172.555 - POISON INHALATION HAZARD placard.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false POISON INHALATION HAZARD placard. 172.555 Section... REQUIREMENTS, AND SECURITY PLANS Placarding § 172.555 POISON INHALATION HAZARD placard. (a) Except for size and color, the POISON INHALATION HAZARD placard must be as follows: ER22JY97.025 (b) In addition...

  16. 49 CFR 172.555 - POISON INHALATION HAZARD placard.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false POISON INHALATION HAZARD placard. 172.555 Section... REQUIREMENTS, AND SECURITY PLANS Placarding § 172.555 POISON INHALATION HAZARD placard. (a) Except for size and color, the POISON INHALATION HAZARD placard must be as follows: ER22JY97.025 (b) In addition...

  17. 49 CFR 172.555 - POISON INHALATION HAZARD placard.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false POISON INHALATION HAZARD placard. 172.555 Section... REQUIREMENTS, AND SECURITY PLANS Placarding § 172.555 POISON INHALATION HAZARD placard. (a) Except for size and color, the POISON INHALATION HAZARD placard must be as follows: ER22JY97.025 (b) In addition...

  18. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  19. Species susceptibility to locoweed poisoning and evaluation of chicks as a small animal model of poisoning

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Locoweed poisoning has largely been attributed to the effects of mannosidase inhibiting swainsonine. However, there are many plants that contain mixtures of swainsonine and other glycosidase inhibiting alkaloids such as calystegines, castanospermine, and other minor alkaloids or metabolites like le...

  20. The management and outcome of open fractures of the femur sustained on the battlefield over a ten-year period.

    PubMed

    Bennett, P M; Sargeant, I D; Myatt, R W; Penn-Barwell, J G

    2015-06-01

    This is a retrospective study of survivors of recent conflicts with an open fracture of the femur. We analysed the records of 48 patients (48 fractures) and assessed the outcome. The median follow up for 47 patients (98%) was 37 months (interquartile range 19 to 53); 31 (66%) achieved union; 16 (34%) had a revision procedure, two of which were transfemoral amputation (4%). The New Injury Severity Score, the method of fixation, infection and the requirement for soft-tissue cover were not associated with a poor outcome. The degree of bone loss was strongly associated with a poor outcome (p = 0.00204). A total of four patients developed an infection; two with S. aureus, one with E. coli and one with A. baumannii. This study shows that, compared with historical experience, outcomes after open fractures of the femur sustained on the battlefield are good, with no mortality and low rates of infection and late amputation. The degree of bone loss is closely associated with a poor outcome. PMID:26033067

  1. The airborne network definition project: a network architecture effort for future battlefield networks that enable network-centric warfare

    NASA Astrophysics Data System (ADS)

    Ganguly, Bishwaroop; Finn, Steven; McLamb, Jeffrey; Bynoe, Wayne; Veytser, Leonid; Pedan, Igor; Mineweaser, Jeremy; Davidson, Steven

    2007-04-01

    The Airborne Network Definition (AND) project had the goal of creating and testing a robust, efficient network architecture networking all elements of the battlefield. This effort has since been generalized to fit the goals of the Mobile Edge Network System Architecture (MENSA) effort. The network is designed to be self-contained, attaching to fixed backbone infrastructure whenever possible. The fundamental building block of the architecture is the Small Combat Network (SCN), which integrates heterogeneous ground and air platforms, facilitating collaborative applications such as Blue Force Tracking, Cooperative Sensing and Targeting. The architecture uses the concept of an IP core to network unlike domains (radio types) and to connect the SCN to the backbone and the Global Information Grid (GIG). This paper describes the requirements of the network and outlines the technical design of the SCN architecture. We present step-by-step descriptions of a communication on the SCN which highlights some of the key features of the architecture. We present results of a simulation that applies our proposed architecture to realistic warfighting scenarios. Results show that the architecture enables cooperative applications and point to future work that will design and evaluate a deployable AN network architecture.

  2. Characterization of infrared imaging performance within a general statistical framework for environmental impacts on battlefield signals and sensing

    NASA Astrophysics Data System (ADS)

    Wilson, D. Keith; Borden, Christopher T.; Bettencourt, Elizabeth S.; Yamamoto, Kenneth K.

    2013-05-01

    The Environmental Awareness for Sensor and Emitter Employment (EASEE) software models the impacts of terrain and weather on a diverse range of battlefield sensing systems. The goal is to provide mission planning tools that realistically capture complex environmental factors impacting sensor performance, yet are simple enough for users with little specialized training. This paper describes incorporation of infrared (IR) modeling into EASEE, and the subsequent challenges of supporting imaging sensors within a framework that had previously evolved primarily for non-imaging sensors, such as acoustic and seismic. The design requires independently interchangeable modules for signature generation, propagation, and signal processing. Sensor performance metrics, such as probability of detection, are characterized statistically rather than through simulation of actual images. Some key enhancements needed to support imaging sensors were: (1) geometric models for targets, (2) packaging of multiple attributes representing target image properties (radiance, projected area, and spatial spectrum), (3) explicitly distinguishing between signals for the background, target of interest, and nuisance targets, and (4) calculation of apparent temperature differences (as opposed to incoherent energy summation). Target signatures are generated using MuSES (Multi-Service Electro-optic Signature), whereas the IR background properties are generated using FASST (Fast All-Season Soil STrength) and numerical weather prediction models. Propagation is handled primarily with MODTRAN (MODerate resolution atmospheric TRANsmission), although simpler models such as a line-of-sight calculation can also be employed. The Johnson criteria were added to the available library of detection algorithms.

  3. Predicting Outcome in Acute Organophosphorus Poisoning with a Poison Severity Score or the Glasgow Coma Scale

    PubMed Central

    Davies, James O. J.; Eddleston, Michael; Buckley, Nick A.

    2008-01-01

    Background: Organophosphorus pesticide poisoning kills around 200,000 people each year, principally due to self poisoning in the Asia-Pacific region. Aim: We wished to assess whether patients at high risk of death could be identified accurately using clinical parameters soon after hospital admission. Design: We evaluated the usefulness of the International Program on Chemical Safety Poison Severity Score (IPCS PSS) and the Glasgow Coma Score (GCS) prospectively for predicting death in patients poisoned by organophosphorus pesticides. Methods: Data were collected as part of a multicentre cohort study in Sri Lanka. Study doctors saw all patients on admission, collecting data on pulse, blood pressure, pupil size, need for intubation, and GCS. Results: 1365 patients with a history of acute organophosphorus poisoning were included. Receiver operating characteristic (ROC) curves were calculated for the IPCS PSS and GCS on admission. The IPCS PSS and GCS had similar ROC area under the curves (AUC) and best cut points as determined by Youden's index (AUC/sensitivity/specificity 0.81/0.78/0.79 for IPCS PSS ≥ grade 2 and 0.84/0.79/0.79 for GCS ≤13). The predictive value varied with the pesticide ingested, being more accurate for dimethoate poisoning and less accurate for fenthion poisoning (GCS AUC 0.91 compared to 0.69). Conclusions: GCS and the IPCS PSS were similarly effective at predicting outcome. Patients presenting with a GCS ≤ 13 need intensive monitoring and treatment. However, the identity of the organophosphate must be taken into account since the half of all patients who died from fenthion poisoning only had mild symptoms at presentation. PMID:18319295

  4. Acute poisoning: understanding 90% of cases in a nutshell

    PubMed Central

    Greene, S; Dargan, P; Jones, A

    2005-01-01

    The acutely poisoned patient remains a common problem facing doctors working in acute medicine in the United Kingdom and worldwide. This review examines the initial management of the acutely poisoned patient. Aspects of general management are reviewed including immediate interventions, investigations, gastrointestinal decontamination techniques, use of antidotes, methods to increase poison elimination, and psychological assessment. More common and serious poisonings caused by paracetamol, salicylates, opioids, tricyclic antidepressants, selective serotonin reuptake inhibitors, benzodiazepines, non-steroidal anti-inflammatory drugs, and cocaine are discussed in detail. Specific aspects of common paediatric poisonings are reviewed. PMID:15811881

  5. [Food poisoning caused by Bacillus cereus].

    PubMed

    Doğanay, M; Bakici, M Z

    1985-10-01

    An outbreak of food poisoning was observed in Sivas on March 27, 1985 involving 25 patients who work at the same place. Clinical picture was characterized with nausea, abdominal pain and watery diarrhea. B. cereus was isolated from the stool of 4 patients. No other enteropathogens were found.

  6. Food poisonings by ingestion of cyprinid fish.

    PubMed

    Asakawa, Manabu; Noguchi, Tamao

    2014-01-28

    Raw or dried gallbladders of cyprinid fish have long been ingested as a traditional medicine in the Asian countries, particularly in China, for ameliorating visual acuity, rheumatism, and general health; however, sporadic poisoning incidences have occurred after their ingestion. The poisoning causes complex symptoms in patients, including acute renal failure, liver dysfunction, paralysis, and convulsions of limbs. The causative substance for the poisoning was isolated, and its basic properties were examined. The purified toxin revealed a minimum lethal dose of 2.6 mg/20 g in mouse, when injected intraperitoneally. The main symptoms were paralysis and convulsions of the hind legs, along with other neurological signs. Liver biopsy of the euthanized mice clearly exhibited hepatocytes necrosis and infiltration of neutrophils and lymphocytes, suggesting the acute dysfunction of the liver. Blood tests disclosed the characteristics of acute renal failure and liver injury. Infrared (IR) spectrometry, fast atom bombardment (FAB) mass spectrometry, and 1H- and 13C-nuclear magnetic resonance (NMR) analysis indicated, a molecular formula of C27H48O8S, containing a sulfate ester group for the toxin. Thus, we concluded that the structure of carp toxin to be 5α-cyprinol sulfate (5α-cholestane-3α, 7α, 12α, 26, 27-pentol 26-sulfate). This indicated that carp toxin is a nephro- and hepato- toxin, which could be the responsible toxin for carp bile poisoning in humans.

  7. Acute Poisoning in Children in Bahia, Brazil.

    PubMed

    Rodrigues Mendonça, Dilton; Menezes, Marta Silva; Matos, Marcos Antônio Almeida; Rebouças, Daniel Santos; Filho, Jucelino Nery da Conceição; de Assis, Reginara Souza; Carneiro, Leila

    2016-01-01

    Acute poisoning is a frequent accident in childhood, particularly in children under 4 years of age. This was a descriptive study with data collected from standardized forms of the Poison Control Center and patient record charts. All the cases of acute poisoning in children aged 0 to 14 years during the period 2008 to 2012 were selected. The variables studied comprised characteristics of the events and toxic agents, clinical development, and outcome. A total of 657 cases of acute poisoning, with higher frequency in the age-group from 1 to 4 years (48.7%) and male sex (53.4%), were recorded. The occurrences were accidental in 92% of the cases, and 5.8% were due to suicide attempts. Among the toxic agents, medications (28.5%), venomous animals (19.3%), nonvenomous animals (10%), household cleaning products (9.0%), and raticide agents (8.7%) predominated. The majority of cases were characterized as light (73.5%) and around 18% required hospitalization, and there was low lethality (0.5%). PMID:27335994

  8. Fatal diphenhydramine poisoning in a dog

    PubMed Central

    Buchweitz, John P.; Raverty, Stephen A.; Johnson, Margaret B.; Lehner, Andreas F.

    2014-01-01

    We report a fatal diphenhydramine poisoning of a 10-year-old, male poodle-cross dog with pre-existing conditions and suspected co-ingestion of ethanol. This case illustrates that diphenhydramine overdose can be fatal in certain circumstances and that analytical toxicology may play an important role in animal death investigations. PMID:25392554

  9. Fatal diphenhydramine poisoning in a dog.

    PubMed

    Buchweitz, John P; Raverty, Stephen A; Johnson, Margaret B; Lehner, Andreas F

    2014-11-01

    We report a fatal diphenhydramine poisoning of a 10-year-old, male poodle-cross dog with pre-existing conditions and suspected co-ingestion of ethanol. This case illustrates that diphenhydramine overdose can be fatal in certain circumstances and that analytical toxicology may play an important role in animal death investigations.

  10. Poisoning by Indigofera lespedezioides in horses

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Poisoning by Indigofera lespedezioides is reported in horses in the state of Roraima, northern Brazil. The main clinical signs are anorexia, sleepiness, unsteady gait, severe ataxia, weakness, stumbling, and progressive weight loss. To induce the disease experimentally, a 7-year-old horse was introd...

  11. Poisonous Plants. LC Science Tracer Bullet.

    ERIC Educational Resources Information Center

    Carter, Constance, Comp.

    There are a number of sources of information on the more than 700 species of plants, ferns, horsetails, and fungi that can cause toxic, though rarely fatal, reactions in humans and animals. This guide is intended for those who wish to review published materials on poisonous plants in the collections of the Library of Congress. It is not intended…

  12. Potato poisoning - green tubers and sprouts

    MedlinePlus

    ... sprouts URL of this page: //medlineplus.gov/ency/article/002875.htm Potato plant poisoning - green tubers and sprouts To use the ... green tubers or new sprouts of the potato plant. This article is for information only. DO NOT use it ...

  13. Acute Poisoning in Children in Bahia, Brazil

    PubMed Central

    Rodrigues Mendonça, Dilton; Menezes, Marta Silva; Matos, Marcos Antônio Almeida; Rebouças, Daniel Santos; Filho, Jucelino Nery da Conceição; de Assis, Reginara Souza; Carneiro, Leila

    2016-01-01

    Acute poisoning is a frequent accident in childhood, particularly in children under 4 years of age. This was a descriptive study with data collected from standardized forms of the Poison Control Center and patient record charts. All the cases of acute poisoning in children aged 0 to 14 years during the period 2008 to 2012 were selected. The variables studied comprised characteristics of the events and toxic agents, clinical development, and outcome. A total of 657 cases of acute poisoning, with higher frequency in the age-group from 1 to 4 years (48.7%) and male sex (53.4%), were recorded. The occurrences were accidental in 92% of the cases, and 5.8% were due to suicide attempts. Among the toxic agents, medications (28.5%), venomous animals (19.3%), nonvenomous animals (10%), household cleaning products (9.0%), and raticide agents (8.7%) predominated. The majority of cases were characterized as light (73.5%) and around 18% required hospitalization, and there was low lethality (0.5%). PMID:27335994

  14. Carbon monoxide poisoning associated with narghile use.

    PubMed

    Cavus, Umut Yucel; Rehber, Zehra Hamiyet; Ozeke, Ozcan; Ilkay, Erdogan

    2010-05-01

    The case history is presented of a healthy 25-year-old man who was admitted to hospital after two syncopal episodes caused by carbon monoxide poisoning after smoking narghile. Clinicians should be aware of this association when they evaluate syncope in the emergency department, especially in narghile users. PMID:20442182

  15. Acute Oral Poisoning Due to Chloracetanilide Herbicides

    PubMed Central

    Seok, Su-Jin; Choi, Sang-Cheon; Yang, Jong-Oh; Lee, Eun-Young; Song, Ho-Yeon; Hong, Sae-Yong

    2012-01-01

    Chloracetanilide herbicides (alachlor, butachlor, metachlor) are used widely. Although there are much data about chronic low dose exposure to chloracetanilide in humans and animals, there are few data about acute chloracetanilide poisoning in humans. This study investigated the clinical feature of patients following acute oral exposure to chloracetanilide. We retrospectively reviewed the data on the patients who were admitted to two university hospitals from January 2006 to December 2010. Thirty-five patients were enrolled. Among them, 28, 5, and 2 cases of acute alachlor, metachlor, butachlor poisoning were included. The mean age was 49.8 ± 15.4 yr. The poison severity score (PSS) was 17 (48.6%), 10 (28.6%), 5 (14.3%), 2 (5.7%), and 1 (2.9%) patients with a PSS of 0, 1, 2, 3, and 4, respectively. The age was higher for the symptomatic patients (1-4 PSS) than that for the asymptomatic patients (0 PSS) (43.6 ± 15.2 vs 55.7 ± 13.5). The arterial blood HCO3 ¯ was lower in the symptomatic patients (1-4 PSS) than that in the asymptomatic patients (0 PSS). Three patients were a comatous. One patient died 24 hr after the exposure. In conclusion, although chloracetanilide poisoning is usually of low toxicity, elder patients with central nervous system symptoms should be closely monitored and cared after oral exposure. PMID:22323855

  16. Acute oral poisoning due to chloracetanilide herbicides.

    PubMed

    Seok, Su-Jin; Choi, Sang-Cheon; Gil, Hyo-Wook; Yang, Jong-Oh; Lee, Eun-Young; Song, Ho-Yeon; Hong, Sae-Yong

    2012-02-01

    Chloracetanilide herbicides (alachlor, butachlor, metachlor) are used widely. Although there are much data about chronic low dose exposure to chloracetanilide in humans and animals, there are few data about acute chloracetanilide poisoning in humans. This study investigated the clinical feature of patients following acute oral exposure to chloracetanilide. We retrospectively reviewed the data on the patients who were admitted to two university hospitals from January 2006 to December 2010. Thirty-five patients were enrolled. Among them, 28, 5, and 2 cases of acute alachlor, metachlor, butachlor poisoning were included. The mean age was 49.8 ± 15.4 yr. The poison severity score (PSS) was 17 (48.6%), 10 (28.6%), 5 (14.3%), 2 (5.7%), and 1 (2.9%) patients with a PSS of 0, 1, 2, 3, and 4, respectively. The age was higher for the symptomatic patients (1-4 PSS) than that for the asymptomatic patients (0 PSS) (43.6 ± 15.2 vs 55.7 ± 13.5). The arterial blood HCO₃⁻ was lower in the symptomatic patients (1-4 PSS) than that in the asymptomatic patients (0 PSS). Three patients were a comatous. One patient died 24 hr after the exposure. In conclusion, although chloracetanilide poisoning is usually of low toxicity, elder patients with central nervous system symptoms should be closely monitored and cared after oral exposure.

  17. Lead poisoning of a marbled godwit

    USGS Publications Warehouse

    Locke, L.N.; Smith, M.R.; Windingstad, R.M.; Martin, S.J.

    1991-01-01

    A thin adult female marbled godwit (Limosa fedoa) found dead at Benton Lake National Wildlife Refuge, Montana, was found to have 17 ingested lead shot in its gizzard. Its liver contained 51.7 ppm lead (wet weight). Based on these necropsy findings a diagnosis of lead poisoning was made.

  18. Selected Bibliography on Lead Poisoning in Children.

    ERIC Educational Resources Information Center

    Lin-Fu, Jane S., Comp.

    This comprehensive bibliography was prepared in response to the growing interest in the problem of childhood lead poisoning. Most of the papers noted are from the pediatric literature and include only those published in English. A limited number of papers on experiments in laboratory animals are cited. Documents are grouped under several general…

  19. [Acute poisoning by pesticides in children].

    PubMed

    Leveau, P

    2016-07-01

    Acute pesticide poisoning in children is rare but potentially serious. Some clinical patterns (toxidromes) are suggestive of the drug class: cholinergic crisis for organophosphate or carbamate insecticides; neurological syndrome for rodenticides; digestive and respiratory syndrome for herbicides. Treatment is symptomatic and only a few patients are treated with an antidote: atropine and pralidoxime for organophosphate insecticides, vitamin K for anticoagulant rodenticides. PMID:27266642

  20. "The Most Poisonous Force in Technology"

    ERIC Educational Resources Information Center

    Carnevale, Dan

    2007-01-01

    Walt Mossberg, personal-technology columnist for "The Wall Street Journal," highlighted technology trends in his speech to a group of college presidents and other administrators. Mr. Mossberg touched a nerve when he called information-technology departments of large organizations, including colleges, "the most regressive and poisonous force in…

  1. Poisoning by Indigofera lespedezioides in horses.

    PubMed

    Lima, Everton F; Riet-Correa, Franklin; Gardner, Dale R; Barros, Severo S; Medeiros, Rosane M T; Soares, Mauro P; Riet-Correa, Gabriela

    2012-09-01

    Poisoning by Indigofera lespedezioides is reported in horses in the state of Roraima, northern Brazil. The main clinical signs are anorexia, sleepiness, unsteady gait, severe ataxia, weakness, stumbling, and progressive weight loss. To induce the disease experimentally, a 7-year-old horse was introduced in a small paddock invaded by the plant. The first nervous signs were observed 44 days from the start of grazing. The animal was euthanized on day 59. No significant gross lesions were observed upon necropsies of the experimental horse as well as one spontaneously affected horse. Upon histologic examination neuronal lipofuscinosis was observed in the brain, cerebellum, and spinal cord. Wallerian-type degeneration was observed on some mesencephalic tracts. Neuronal and axonal degeneration and lipofuscinosis were observed on electron microscopy examination. Indospicine was detected in four samples of I. lespedezioides with concentrations ranging from 63 to 1178 μg/g whereas nitro toxins could be detected in only one of the samples at a concentration of 2.5 mg/g. In conclusion, poisoning by I. lespedezioides is very similar to those poisonings by Indigofera linnaei and Indigofera hendecaphylla. Based on the preponderance of indospince and lack of nitro toxins in the samples it is proposed that indospicine is the toxic compound responsible for the poisoning.

  2. Sulfate as a precursor of catalyst poisoning

    SciTech Connect

    Mador, I.L.; Rosan, A.M.; Crissey, R.K.

    1984-05-01

    The poisoning of noble metal catalysts of hydrogenation reactions by sulfur in various forms is discussed. The specific reaction investigated was the hydrogenation of phenol to cyclohexanone over palladium. Catalyst pretreatments with NaHSO/sub 4/, PdSO/sub 4/, H/sub 2/, and He produced catalyst activities varying from inactive to unimpaired.

  3. Psychiatric Hospitalization after Deliberate Self-Poisoning

    ERIC Educational Resources Information Center

    Carter, Gregory L.; Safranko, Ivan; Lewin, Terry J.; Whyte, Ian M.; Bryant, Jennifer L.

    2006-01-01

    The decision for psychiatric hospitalization after deliberate self-poisoning (DSP) is not well understood. This study, a longitudinal cohort study of 3,148 consecutive DSP patients found 920 (29.2%) subjects were referred for psychiatric hospitalization, 576 (18.3%) on involuntary basis. A logistic regression analysis showed increased risk for:…

  4. Parathion poisoning of Mississippi kites in Oklahoma

    USGS Publications Warehouse

    Franson, J. Christian

    1994-01-01

    Parathion(phosphorothioic acid O, O-diethyl O-[4-nitrophenyl] ester) is a broad spectrum organophosphorus insecticide, used on a variety of crops and occasionally for mosquito control, and is highly toxic to birds (Smith 1987). Intentional poisoning with parathion is reported to have killed more than 8000 red-winged blackbirds (Agelaius phoeniceus), common grackles (Quiscalus quiscula), brown-headed cowbirds (Molothrus ater) and European starlings (Sturnus vulgaris) in two separate instances (Stone et al. 1984). Use of parathion on wheat fields has resulted in the mortality of about 1600 Canada geese (Branta canadensis) and other waterfowl in one instance (White et al. 1982) and about 200 Canada geese in another (Flickinger et al. 1991). More than 200 laughing gulls (Larus atricilla) died near cotton fields treated with parathion (White et al. 1979). Secondary poisoning of raptors resulting from the consumption of prey exposed to parathion, has been reported experimentally and in the field. Stone et al. (1984) found two dead red-tailed hawks (Buteo jamaicensis), a Cooper's hawk (Accipiter cooperii) and an American kestrel (Falco sparverius) that had fed on blackbirds killed by parathion. One of four American kestrels died after being fed cricket frogs (Acris crepitans) that had been exposed to 10ppm parathion for 96 hr (Fleming et al. 1982). The Mississippi kite (Ictinia mississippensis) is highly insectivorous (Brown and Amadon 1968) and is thus subject to secondary poisoning resulting from consumption of insects exposed to pesticides. I report here an instance of secondary parathion poisoning in wild Mississippi kites.

  5. A systematic review of aluminium phosphide poisoning.

    PubMed

    Mehrpour, Omid; Jafarzadeh, Mostafa; Abdollahi, Mohammad

    2012-03-01

    Every year, about 300,000 people die because of pesticide poisoning worldwide. The most common pesticide agents are organophosphates and phosphides, aluminium phosphide (AlP) in particular. AlP is known as a suicide poison that can easily be bought and has no effective antidote. Its toxicity results from the release of phosphine gas as the tablet gets into contact with moisture. Phosphine gas primarily affects the heart, lungs, gastrointestinal tract, and kidneys. Poisoning signs and symptoms include nausea, vomiting, restlessness, abdominal pain, palpitation, refractory shock, cardiac arrhythmias, pulmonary oedema, dyspnoea, cyanosis, and sensory alterations. Diagnosis is based on clinical suspicion, positive silver nitrate paper test to phosphine, and gastric aspirate and viscera biochemistry. Treatment includes early gastric lavage with potassium permanganate or a combination with coconut oil and sodium bicarbonate, administration of charcoal, and palliative care. Specific therapy includes intravenous magnesium sulphate and oral coconut oil. Moreover, acidosis can be treated with early intravenous administration of sodium bicarbonate, cardiogenic shock with fluid, vasopresor, and refractory cardiogenic shock with intra-aortic baloon pump or digoxin. Trimetazidine may also have a useful role in the treatment, because it can stop ventricular ectopic beats and bigeminy and preserve oxidative metabolism. This article reviews the epidemiological, toxicological, and clinical/pathological aspects of AlP poisoning and its management.

  6. Food Poisonings by Ingestion of Cyprinid Fish

    PubMed Central

    Asakawa, Manabu; Noguchi, Tamao

    2014-01-01

    Raw or dried gallbladders of cyprinid fish have long been ingested as a traditional medicine in the Asian countries, particularly in China, for ameliorating visual acuity, rheumatism, and general health; however, sporadic poisoning incidences have occurred after their ingestion. The poisoning causes complex symptoms in patients, including acute renal failure, liver dysfunction, paralysis, and convulsions of limbs. The causative substance for the poisoning was isolated, and its basic properties were examined. The purified toxin revealed a minimum lethal dose of 2.6 mg/20 g in mouse, when injected intraperitoneally. The main symptoms were paralysis and convulsions of the hind legs, along with other neurological signs. Liver biopsy of the euthanized mice clearly exhibited hepatocytes necrosis and infiltration of neutrophils and lymphocytes, suggesting the acute dysfunction of the liver. Blood tests disclosed the characteristics of acute renal failure and liver injury. Infrared (IR) spectrometry, fast atom bombardment (FAB) mass spectrometry, and 1H- and 13C-nuclear magnetic resonance (NMR) analysis indicated, a molecular formula of C27H48O8S, containing a sulfate ester group for the toxin. Thus, we concluded that the structure of carp toxin to be 5α-cyprinol sulfate (5α-cholestane-3α, 7α, 12α, 26, 27-pentol 26-sulfate). This indicated that carp toxin is a nephro- and hepato- toxin, which could be the responsible toxin for carp bile poisoning in humans. PMID:24476713

  7. Poisonous Plants of the United States

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Poisonous plants cause significant economic losses to the livestock industry throughout the world from death losses, abortions, birth defects, increased veterinary care, and other related factors. This chapter is not intended to be all-inclusive, but provides current research information on importan...

  8. Variability in the management of lithium poisoning.

    PubMed

    Roberts, Darren M; Gosselin, Sophie

    2014-01-01

    Three patterns of lithium poisoning are recognized: acute, acute-on-chronic, and chronic. Intravenous fluids with or without an extracorporeal treatment are the mainstay of treatment; their respective roles may differ depending on the mode of poisoning being treated. Recommendations for treatment selection are available but these are based on a small number of observational studies and their uptake by clinicians is not known. Clinician decision-making in the treatment of four cases of lithium poisoning was assessed at a recent clinical toxicology meeting using an audience response system. Variability in treatment decisions was evident in addition to discordance with published recommendations. Participants did not consistently indicate that hemodialysis was the first-line treatment, instead opting for a conservative approach, and continuous modalities were viewed favorably; this is in contrast to recommendations in some references. The development of multidisciplinary consensus guidelines may improve the management of patients with lithium poisoning but prospective randomized controlled trials are required to more clearly define the role of extracorporeal treatments.

  9. Carbon Monoxide Poisoning in an Elementary School

    ERIC Educational Resources Information Center

    Comfort, Robert J.; Daveler, Jay

    1977-01-01

    Described is an investigation conducted by municipal inspection and code enforcement personnel following an episode of carbon monoxide poisoning among elementary school children in a small eastern Pennsylvania community in 1975. The need for a reevaluation of existing building code standards is emphasized. (BT)

  10. Naturally Occurring Fish Poisons from Plants

    ERIC Educational Resources Information Center

    Cannon, Jonathan G.; Burton, Robert A.; Wood, Steven G.; Owen, Noel L.

    2004-01-01

    The fish poisons derived from plants used throughout the world, not only as piscicides but also for a range of other uses, including insecticident and in folk medicines, is presented. The aim of this review is to provide a useful background for students interested in natural products.

  11. Status epilepticus: An association with pyrethroid poisoning

    PubMed Central

    Panwar, Mamta; Usha, Ganapathy; Kumath, Manish

    2013-01-01

    This report describes a 35 year old male who presented with seizures after consuming 4-5 bottles of “ALL-OUT” a commercial composition of pyrethroid used as insecticides. Our case report supports authors reporting an association of pyrethroid poisoning with status epilepticus. PMID:23983421

  12. [A CASE OF SEVERE AMLODIPINE POISONING].

    PubMed

    Spasova, A P; Loginov, A V; Jurovickij, V L; Barysheva, O Yu; Strategopulo, V A

    2015-01-01

    The article is devoted to the actual problem--poisoning by calcium channel blockers. The case of the departure of the patient amlodipine, clinical picture, treatment and its effectiveness. In the discussion described pharmacological characteristics of the group of calcium channel blockers, mechanisms of development syndromes developing in this type of shipment and pathogenetic approach to therapy.

  13. Renal Failure Prevalence in Poisoned Patients

    PubMed Central

    Arefi, Mohammad; Taghaddosinejad, Fakhroddin; Salamaty, Peyman; Soroosh, Davood; Ashraf, Hami; Ebrahimi, Mohsen

    2014-01-01

    Background: Renal failure is an important adverse effect of drug poisoning. Determining the prevalence and etiology of this serious side effect could help us find appropriate strategies for the prevention of renal failure in most affected patients. Objectives: The present study is aimed to identify drugs that induce renal failure and also to find the prevalence of renal failure in patients referred to emergency departments with the chief complaint of drug poisoning, in order to plan better therapeutic strategies to minimize the mortality associated with drug poisoning induced renal failure. Patients and Methods: This cross-sectional study surveyed 1500 poisoned patients referred to the Emergency Department of Baharloo Hospital in Tehran during 2010. Demographic data including age and gender as well as clinical data including type of medication, duration of hospital stay, and presence of renal failure were recorded. Mann-Whitney U test and chi-squared statistics were used to analyze the results. Results: A total number of 435 patients were poisoned with several drugs, 118 patients were intoxicated with sedative-hypnotic drugs, 279 patients were exposed to opium, and 478 patients were administered to other drugs. The method of intoxication included oral 84.3%, injective 9%, inhalation 4.3% and finally a combination of methods 2.3%. Laboratory results revealed that 134 cases had renal failure and 242 had rhabdomyolysis. The incidence of rhabdomyolysis and renal failure increased significantly with age, and also with time of admission to the hospital. Renal failure was reported in 25.1% of patients exposed to opium, vs. 18.2% of patients poisoned with aluminum phosphide, 16.7% of those with organophosphate, 8% with multiple drugs, 6.7% with alcohol, heavy metals and acids, and 1.7% with sedative hypnotics. Conclusions: Based on the findings of this study, there is a high probability of renal failure for patients poisoned with drugs such as opium, aluminum phosphide

  14. Recent Advances in the Clinical Management of Lead Poisoning.

    PubMed

    Kianoush, Sina; Sadeghi, Mahmood; Balali-Mood, Mahdi

    2015-01-01

    Lead poisoning is a historic universal disease. Acute or chronic lead exposure may cause reversible or even permanent damages in human beings. Environmental lead exposure is a global health concern in children. Occupational lead poisoning is still a health issue, particularly in developing countries. During the last decades, new methods and medications have been advocated for the prevention and treatment of lead poisoning. This review deals mainly with recent developments in the management of lead poisoning. Sources of lead exposure are introduced, and methods for the primary prevention of lead poisoning are discussed. Details for the screening of adults and children are also explained to serve as a practical guideline for the secondary prevention. Standard chelation therapy in different groups and up-to-date less toxic new medications for the treatment of lead poisoning are finally discussed. Our published clinical research on the therapeutic effects of garlic tablets in mild to moderate occupational lead poisoning will also be discussed.

  15. The Pittsburgh Poison Center and its member hospital network.

    PubMed

    Dean, B S; Krenzelok, E P

    1986-02-01

    When a poison information call involves a case that requires medical intervention, the staff of poison information specialists refer the poisoned patient to the emergency department of the nearest member hospital. This regionalization of treatment involving poison exposures eliminates the necessity of having an emergent patient rushed long distances to receive prompt and effective care. Facsimile terminals provide an efficacious method of enhancing communication of toxicology information to our member hospital treatment centers. A poison center is able to electronically transmit copies of written documents such as newly published journal articles or treatment protocols directly to the emergency department of the treating hospital. In turn, the facsimile terminal can confidentially transmit a copy of a poisoned victim's emergency record to the poison center. Data collection and documentation is strengthened. Transmission and receiving is accomplished within minutes. PMID:3705433

  16. Clinical symptomatology and management of mushroom poisoning.

    PubMed

    Köppel, C

    1993-12-01

    Among poisonous mushrooms, a small number may cause serious intoxication and even fatalities in man. Humans may become symptomatic after a mushroom meal for rather different reasons: (1) ingestion of mushrooms containing toxins, (2) large amounts of mushrooms may be hard to digest, (3) immunological reactions to mushroom-derived antigens, (4) ingestion of mushrooms causing ethanol intolerance, and (5) vegetative symptoms may occur whenever a patient realizes that there might be a possibility of ingestion of a toxic mushroom after a mushroom meal. Based on the classes of toxins and their clinical symptoms, seven different types of mushroom poisoning can be distinguished: (1) phalloides, (2) orellanus, (3) gyromitra, (4) muscarine, (5) pantherina, (6) psilocybin, and (7) gastrointestinal mushroom syndrome. Two other entities of adverse reactions to mushrooms are (8) coprinus and (9) paxillus syndrome. Phalloides, orellanus, gyromitra and paxillus syndrome may lead to serious poisoning, which generally requires treatment of the patient in an intensive care unit. Diagnosis of mushroom poisoning is primarily based on anamnestic data, identification of mushrooms from leftovers of the mushroom meal, spore analysis, and/or chemical analysis. Therapeutic strategies include primary detoxification by induced emesis, gastric lavage and activated charcoal, secondary detoxification, symptomatic treatment and rarely specific antidotes. Owing to progressing fulminant hepatic failure, lethality associated with phalloides syndrome is still high (5-20%). Basic treatment includes administration of silibinin and penicillin G, although controlled studies on its therapeutic efficacy are still lacking. In serious phalloides syndrome, orthotopic liver transplantation has to be considered. Fortunately, the prognosis in most other mushroom poisonings is excellent.

  17. Battlefield Utility of Antipersonnel Landmines and Proposed Alternatives (Analysis in Support of the NATO SAS-023 APM Study)

    SciTech Connect

    Crandley, J F; Greenwalt, R J; Magnoli, D E; Randazzo, A S

    2002-02-05

    This study consists of work done in support of the U.S. delegation to the NATO SAS-023 Antipersonnel Landmine Study Group, supplemented by additional work done for the U.S. Office of the Secretary of Defense Antipersonnel Landmine Alternative Concept Exploration Program (Track III). It explores the battlefield utility of current antipersonnel landmines (APL) in both pure and mixed APL/antitank minefields and evaluates the value of military suggested non-materiel alternatives. The historical record is full of examples where the presence (or absence) of antipersonnel landmines made a critical difference in battle. The current generation of military thinkers and writers lack any significant combat experience employing either mixed or antipersonnel minefields, which leaves a critical gap in available expert advice for policy and decision-makers. Because of this lack of experienced-based professional military knowledge, Lawrence Livermore National Laboratory analyzed the employment of antipersonnel landmines in tactical mixed minefields and in protective antipersonnel minefields. The scientific method was employed where hypotheses were generated from the tactics and doctrine of the antipersonnel landmine era and tested in a simulation laboratory. A high-resolution, U.S. Joint Forces Command combat simulation model (the Joint Conflict and Tactical Simulation--JCATS) was used as the laboratory instrument. A realistic European scenario was obtained from a multi-national USAREUR exercise and was approved by the SAS-023 panel members. Additional scenarios were provided by U.S. CINC conferences and were based on Southwest Asia and Northeast Asia. Weapons data was obtained from the U.S. family of Joint Munitions Effectiveness Manuals. The U.S. Army Materiel Systems Analysis Agency conducted a limited verification and validation assessment of JCATS for purposes of this study.

  18. Mutagenicity monitoring following battlefield exposures: Longitudinal study of HPRT mutations in Gulf War I veterans exposed to depleted uranium.

    PubMed

    Albertini, Richard J; Vacek, Pamela M; Carter, Elizabeth W; Nicklas, Janice A; Squibb, Katherine S; Gucer, Patricia W; Engelhardt, Susan M; McDiarmid, Melissa A

    2015-08-01

    A total of 70 military Veterans have been monitored for HPRT T-cell mutations in five separate studies at 2-year intervals over an 8-year period. Systemic depleted uranium (DU) levels were measured at the time of each study by determining urinary uranium (uU) excretion. Each HPRT study included 30-40 Veterans, several with retained DU-containing shrapnel. Forty-nine Veterans were evaluated in multiple studies, including 14 who were in all five studies. This permitted a characterization of the HPRT mutation assay over time to assess the effects of age, smoking and non-selected cloning efficiencies, as well as the inter- and intra-individual variability across time points. Molecular analyses identified the HPRT mutation and T-cell receptor (TCR) gene rearrangement in 1,377 mutant isolates. An unexpected finding was that in vivo clones of HPRT mutant T-cells were present in some Veterans, and could persist over several years of the study. The calculated HPRT mutant frequencies (MFs) were repeatedly elevated in replicate studies in three outlier Veterans with elevated urinary uranium excretion levels. However, these three outlier Veterans also harbored large and persistent in vivo HPRT mutant T-cell clones, each of which was represented by a single founder mutation. Correction for in vivo clonality allowed calculation of HPRT T-cell mutation frequencies (MutFs). Despite earlier reports of DU associated increases in HPRT MFs in some Veterans, the results presented here demonstrate that HPRT mutations are not increased by systemic DU exposure. Additional battlefield exposures were also evaluated for associations with HPRT mutations and none were found.

  19. Force Protection Joint Experiment (FPJE) Battlefield Anti-Intrusion System (BAIS) sensors data analysis and filtering metrics

    NASA Astrophysics Data System (ADS)

    Barngrover, C. M.; Laird, R. T.; Kramer, T. A.; Cruickshanks, J. R.; Cutler, S. H.

    2009-04-01

    The FPJE was an experiment to consider the best way to develop and evaluate a system of systems approach to Force Protection. It was sponsored by Physical Security Equipment Action Group (PSEAG) and Joint Program Manager - Guardian (JPM-G), and was managed by the Product Manager - Force Protection Systems (PM-FPS). The experiment was an effort to utilize existing technical solutions from all branches of the military in order to provide more efficient and effective force protection. The FPJE consisted of four separate Integration Assessments (IA), which were intended as opportunities to assess the status of integration, automation and fusion efforts, and the effectiveness of the current configuration and "system" components. The underlying goal of the FPJE was to increase integration, automation, and fusion of the many different sensors and their data to provide enhanced situational awareness and a common operational picture. One such sensor system is the Battlefield Anti-Intrusion System (BAIS), which is a system of seismic and acoustic unmanned ground sensors. These sensors were originally designed for employment by infantry soldiers at the platoon level to provide early warning of personnel and vehicle intrusion in austere environments. However, when employed around airfields and high traffic areas, the sensitivity of these sensors can cause an excessive number of detections. During the second FPJE-IA all of the BAIS detections and the locations of all Opposing Forces were logged and analyzed to determine the accuracy rate of the sensors. This analysis revealed that with minimal filtering of detections, the number of false positives and false negatives could be reduced substantially to manageable levels while using the sensors within extreme operational acoustic and seismic noise conditions that are beyond the design requirements.

  20. Fischer-Tropsch fuel for use by the U.S. military as battlefield-use fuel of the future

    SciTech Connect

    Delanie Lamprecht

    2007-06-15

    The United States Department of Defense (DoD) has been interested in low-sulfur, environmentally cleaner Fischer-Tropsch (FT) fuels since 2001 because they want to be less dependent upon foreign crude oil and ensure the security of the supply. A three-phase Joint Battlefield-Use Fuel of the Future (BUFF) program was initiated to evaluate, demonstrate, certify, and implement turbine fuels produced from alternative energy resources for use in all of its gas turbine and diesel engine applications. Sasol Synfuels International (Pty) Ltd. and Sasol Chevron Holdings Ltd., among others, were invited to participate in the program with the objective to supply the DoD with a FT BUFF that conforms to Jet Propulsion 8 (JP-8) and JP-5 fuel volatility and low-temperature fluidity requirements. Although the DoD is more interested in coal-to-liquid (CTL) technology, the product from a gas-to-liquid (GTL) Products Work-Up Demonstration Unit in Sasolburg, South Africa, was used to evaluate (on a bench scale) the possibility of producing a BUFF fraction from the Sasol Slurry Phase Distillate (Sasol SPD) low-temperature FT (LTFT) process and Chevron Isocracking technology. It was concluded from the study that the production of a synthetic FT BUFF is feasible using the Sasol SPD LTFT technology together with the current Chevron isocracking technology. The product yield for a BUFF conforming to JP-8 requirements is 30 vol % of the fractionator feed, whereas the product yield for a BUFF conforming to the JP-5 volatility requirement is slightly less than 22 vol % of the fractionator feed. Also concluded from the study was that the end point of the Sasol SPD LTFT BUFF will be restricted by the freezing point requirement of the DoD and not the maximum viscosity requirement. One would therefore need to optimize the hydrocracking process conditions to increase the Sasol SPD LTFT BUFF product yield. 16 refs., 8 figs., 6 tabs.