The Permian-Triassic granitoids in Bayan Obo, North China Craton: A geochemical and geochronological study

NASA Astrophysics Data System (ADS)

Ling, Ming-Xing; Zhang, Hong; Li, He; Liu, Yu-Long; Liu, Jian; Li, Lin-Qing; Li, Cong-Ying; Yang, Xiao-Yong; Sun, Weidong

2014-03-01

Granitoids near the Bayan Obo giant rare earth element (REE) deposit at the north margin of the North China Craton (NCC), the world's largest light REE (LREE) deposit, have been taken by some authors as the key factors that controlled the mineralization. In contrast, others proposed that the REE deposit has been partially destructed by these granitoids. Here we report systematic studies on geochronology and geochemical characteristics of granitoids of different distances from the orebodies, to investigate the genesis and their relationship to the giant Bayan Obo deposit. Granitoids studied here, including granites and quartz monzonites, are peraluminous with A/CNK = 0.99-1.11, LREE enriched and heavy REE (HREE) depleted, with variable REE concentrations (total REE = 54-330 ppm) and large negative Eu anomaly (δEu = 0.19-0.70). The REE patterns are distinct from those of ore-bearing dolomites. Some samples have slightly higher LREE concentrations, which may have been contaminated by the orebodies during intrusion. Trace elements of the granitoids are characterized by positive Pb anomaly, strong negative Ti anomaly and Nb, Ta and Sr anomalies. The granites exhibit negative Ba anomaly. The granitoids plot within the post-collision granite field in the Pearce diagram, which is consistent with the tectonic regime. The quartz monzonites and one granite have A-type granite characteristics and belong to the A2 subgroup. Zircons in these granitoids have high Th/U values, which are typical for magmatic zircons. High precision U-Pb dating for these zircons by secondary ion mass spectrometry (SIMS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) yields Permian-Triassic 206Pb/238U ages ranging from 243.2 to 293.8 Ma. The formation of the granitoids is > 55 Ma later than the latest ore forming age. The zircons have low La concentrations (0.02-12 ppm), high (Sm/La)N (0.8-685) and Ce/Ce* (1.4-80). The Ti-in-zircon temperature of the granitoids ranges from 590 to 770 °C. All these evidences suggest that the granitoids have no contribution to the formation of the Bayan Obo deposit. Granitoids that are close to the orebodies had limited interaction with it and gained some LREE-enriched characteristics during magmatisms. Nevertheless, their effects to the orebodies are subtle. All the granitoids formed in a post-collisional tectonic regime at convergent margins, which is consistent with plate subduction during the closure of the Palaeo-Asian Ocean, which started in the Neoproterozoic and lasted until the Carboniferous/Permian.

Harnessing the power of microbial nanowires.

PubMed

Reguera, Gemma

2018-05-27

The reduction of iron oxide minerals and uranium in model metal reducers in the genus Geobacter is mediated by conductive pili composed primarily of a structurally divergent pilin peptide that is otherwise recognized, processed and assembled in the inner membrane by a conserved Type IVa pilus apparatus. Electronic coupling among the peptides is promoted upon assembly, allowing the discharge of respiratory electrons at rates that greatly exceed the rates of cellular respiration. Harnessing the unique properties of these conductive appendages and their peptide building blocks in metal bioremediation will require understanding of how the pilins assemble to form a protein nanowire with specialized sites for metal immobilization. Also important are insights into how cells assemble the pili to make an electroactive matrix and grow on electrodes as biofilms that harvest electrical currents from the oxidation of waste organic substrates. Genetic engineering shows promise to modulate the properties of the peptide building blocks, protein nanowires and current-harvesting biofilms for various applications. This minireview discusses what is known about the pilus material properties and reactions they catalyse and how this information can be harnessed in nanotechnology, bioremediation and bioenergy applications. © 2018 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

The Bayan Obo iron-rare-earth-niobium deposits, Inner Mongolia, China

USGS Publications Warehouse

Drew, Lawrence J.; Qingrun, Meng; Weijun, Sun

1990-01-01

The plate tectonic setting, regional geology and certain aspects of the economic geology of the iron-rare-earth-niobium ore bodies at Bayan Obo, Inner Mongolia, China, were studied by a team of geologists from the Tianjin Geologic Research Academy and the U.S. Geological Survey between 1987 and 1989. These ore bodies were formed by hydrothermal replacement of Middle Proterozoic dolomite in an intra-continental rift setting. A variety of veins and/or dikes that have a carbonatitelike mineralogy cut the footwall clastic rocks and migmatites. A stockwork of veins occurs at several locations in the footwall. The hanging wall is a shale that has been converted to a K-metasomatite and has microcrystalline potassium feldspar as its principal constituent. This shale served as a sealing caprock that contained the chemical solutions that reacted with the dolomite and created the enormous concentration of mineralized rock in an 18-kilometer-long syncline. The rocks that host these ore bodies and the associated mineralized areas occur today as roof pendants in granitoid rocks of Permian age that were emplaced during a continent-to-continent collision during that period.

Investigating Heavy Metal Pollution in Mining Brownfield and Its Policy Implications: A Case Study of the Bayan Obo Rare Earth Mine, Inner Mongolia, China

NASA Astrophysics Data System (ADS)

Pan, Yuxue; Li, Haitao

2016-04-01

The rapid urbanization of China and associated demand for land resources necessitates remediation, redevelopment, and reclamation of contaminated soil. Before these measures are taken, a basic investigation and inventory of heavy metal (HM) pollution levels in contaminated soil is necessary for establishing and implementing the redevelopment plan. In the present study, to identify the policy implications of inventorying and mapping HM pollution of soil in brownfields throughout China, the Bayan Obo giant rare earth element (REE)-Nb-Fe ore deposit of Baotou in Inner Mongolia, China, which is the largest REE mineral deposit in the world, was taken as a case study. Soil samples from 24 sites in Bayan Obo mining area (MA) and 76 sites in mine tailing area (TA) were collected for determining contents of soil HMs (Cr, Cd, Pb, Cu, and Zn). The results showed that the average concentrations of Cr, Cd, Pb, Cu, and Zn in both MA and TA were all higher than their corresponding background values for Inner Mongolia but lower than the Class II criteria of the National Soil Quality Standards of China (GB 15618—1995). Enrichment factor (EF) analysis of the soil samples indicated that the soil in the brownfield sites was highly enriched with Cr, Cd, Pb, Cu, and Zn compared to the corresponding background values. In MA, the EF for Cd was the highest among the studied elements, while in TA, the EF for Cr (3.45) was the highest, closely followed by the EF for Cd (3.34). The potential ecological risk index (RI) indicated a moderate potential ecological risk from the studied HMs in MA and a low potential ecological risk in TA, and the results of RI also suggested that the soil was most heavily polluted by Cd. According to the spatial distribution maps of HM, contamination hot-spots were primarily located near mining-related high-pollution plants. Based on the results, policy recommendations are proposed related to brownfield management in urban planning.

Investigating Heavy Metal Pollution in Mining Brownfield and Its Policy Implications: A Case Study of the Bayan Obo Rare Earth Mine, Inner Mongolia, China.

PubMed

Pan, Yuxue; Li, Haitao

2016-04-01

The rapid urbanization of China and associated demand for land resources necessitates remediation, redevelopment, and reclamation of contaminated soil. Before these measures are taken, a basic investigation and inventory of heavy metal (HM) pollution levels in contaminated soil is necessary for establishing and implementing the redevelopment plan. In the present study, to identify the policy implications of inventorying and mapping HM pollution of soil in brownfields throughout China, the Bayan Obo giant rare earth element (REE)-Nb-Fe ore deposit of Baotou in Inner Mongolia, China, which is the largest REE mineral deposit in the world, was taken as a case study. Soil samples from 24 sites in Bayan Obo mining area (MA) and 76 sites in mine tailing area (TA) were collected for determining contents of soil HMs (Cr, Cd, Pb, Cu, and Zn). The results showed that the average concentrations of Cr, Cd, Pb, Cu, and Zn in both MA and TA were all higher than their corresponding background values for Inner Mongolia but lower than the Class II criteria of the National Soil Quality Standards of China (GB 15618-1995). Enrichment factor (EF) analysis of the soil samples indicated that the soil in the brownfield sites was highly enriched with Cr, Cd, Pb, Cu, and Zn compared to the corresponding background values. In MA, the EF for Cd was the highest among the studied elements, while in TA, the EF for Cr (3.45) was the highest, closely followed by the EF for Cd (3.34). The potential ecological risk index (RI) indicated a moderate potential ecological risk from the studied HMs in MA and a low potential ecological risk in TA, and the results of RI also suggested that the soil was most heavily polluted by Cd. According to the spatial distribution maps of HM, contamination hot-spots were primarily located near mining-related high-pollution plants. Based on the results, policy recommendations are proposed related to brownfield management in urban planning.

Tectonic Divisions Based on Gravity Data and Earthquake Distribution Characteristics in the North South Seismic Belt, China

NASA Astrophysics Data System (ADS)

Tian, T.; Zhang, J.; Jiang, W.

2017-12-01

The North South Seismic Belt is located in the middle of China, and this seismic belt can be divided into 12 tectonic zones, including the South West Yunnan (I), the Sichuan Yunnan (II), the Qiang Tang (III), the Bayan Har (IV), the East Kunlun Qaidam (V), the Qi Lian Mountain (VI), the Tarim(VII), the East Alashan (VIII), the East Sichuan (IX), the Ordos(X), the Middle Yangtze River (XI) and the Edge of Qinghai Tibet Block (XII) zone. Based on the Bouguer Gravity data calculated from the EGM2008 model, the Euler deconvolution was used to obtain the edge of tectonic zone to amend the traditional tectonic divisions. In every tectonic zone and the whole research area, the logarithm of the total energy of seismic was calculated. The Time Series Analysis (TSA) for all tectonic zones and the whole area were progressed in R, and 12 equal divisions were made (A1-3, B1-3, C1-3, D1-3) by latitude and longitude as a control group. A simple linear trend fitting of time was used, and the QQ figure was used to show the residual distribution features. Among the zones according to Gravity anomalies, I, II and XII show similar statistical characteristic, with no earthquake free year (on which year there was no earthquake in the zone), and it shows that the more seismic activity area is more similar in statistical characteristic as the large area, no matter how large the zone is or how many earthquakes are in the zone. Zone IV, V, IX, III, VII and VIII show one or several seismic free year during 1970s (IV, V and IX) and 1980s (III, VII and VIII), which may implicate the earthquake activity were low decades ago or the earthquake catalogue were not complete in these zones, or both. Zone VI, X and XI show many earthquake free years even in this decade, which means in these zones the earthquake activity were very low even if the catalogue were not complete. In the control group, the earthquake free year zone appeared random and independent of the seismic density, and in all equal divided zones with seismic free years, the seismic free years all appeared in 1970s, which only related to the incompleteness of the earthquake catalogue in the west area of China. In conclusion, the tectonic divisions based on Gravity anomalies can provide a more efficient way to add space factor in the time series analysis with specific tectonic implications.

A Complete Handbook on Backyward and Commercial Rabbit Production = Sa Kalusugan ng Bayan Rabbit Ang Alagaan. Appropriate Technologies for Development. Reprint R-41.

ERIC Educational Resources Information Center

Sicwaten, Juan B.; Stahl, Diane

This handbook on rabbit raising, prepared for use by Peace Corps volunteers, attempts to share information gained by rabbit raisers in the Philippines along with information gathered from academic sources. The manual provides step-by-step information on how to begin and carry out a program of rabbit production. The 15 sections of the guide cover…

Sr-Nd-Pb isotope systematics of the Permian volcanic rocks in the northern margin of the Alxa Block (the Shalazhashan Belt) and comparisons with the nearby regions: Implications for a Permian rift setting?

NASA Astrophysics Data System (ADS)

Shi, Guanzhong; Wang, Hua; Liu, Entao; Huang, Chuanyan; Zhao, Jianxin; Song, Guangzeng; Liang, Chao

2018-04-01

The petrogenesis of the Permian magmatic rocks in the Shalazhashan Belt is helpful for us to understand the tectonic evolution of the Central Asian Orogenic Belt (CAOB) in the northern margin of the Alxa Block. The Permian volcanic rocks in the Shalazhashan Belt include basalts, trachyandesites and trachydacites. Our study shows that two basalt samples have negative εNd(t) values (-5.4 to -1.5) and higher radiogenic Pb values, which are relevant to the ancient subcontinental lithospheric mantle. One basalt sample has positive εNd(t) value (+10) representing mafic juvenile crust and is derived from depleted asthenosphere. The trachyandesites are dated at 284 ± 3 Ma with εNd(t) = +2.7 to +8.0; ISr = 0.7052 to 0.7057, and they are generated by different degrees of mixing between mafic magmas and crustal melts. The trachydacites have high εNd(t) values and slightly higher ISr contents, suggesting the derivation from juvenile sources with crustal contamination. The isotopic comparisons of the Permian magmatic rocks of the Shalazhashan Belt, the Nuru-Langshan Belt (representing the northern margin of the Alxa Block), the Solonker Belt (Mandula area) and the northern margin of the North China Craton (Bayan Obo area) indicate that the radiogenic isotopic compositions have an increasingly evolved trend from the south (the northern margins of the Alxa Block and the North China Craton) to the north (the Shalazhashan Belt and the Solonker Belt). Three end-member components are involved to generate the Permian magmatic rocks: the ancient subcontinental lithospheric mantle, the mafic juvenile crust or newly underplated mafic rocks that were originated from depleted asthenosphere, and the ancient crust. The rocks correlative with the mafic juvenile crust or newly underplated mafic rocks are predominantly distributed along the Shalazhashan Belt and the Solonker Belt, and the rocks derived from ancient, enriched subcontinental lithospheric mantle are mainly distributed along the northern margins of the Alxa Block and the North China Craton. The magmatic rock types, isotopic features and their temporal, spatial distributions suggest an extensional regime probably related to rifting.

JPRS Report, East Asia, Southeast Asia

DTIC Science & Technology

1988-05-03

Bayan Chief on Impact , Criticism of Efforts ’.’.’.’."’." 39 Election Official Says Postponement Geared To Defeat Rebel Candidates """ŕ"! 43...duplicating machines, 22 typewriters, three televi- sion sets, one video deck, four radio cassettes, two cameras, 23 elephants , 24 horses/mules, 1,451...daw (Navy) vessels are on constant patrol and 132 fish- poaching vessels, 111 black-market vessels and 1,409 fish poachers were seized between 21

Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction.

PubMed

Woerly, Eric M; Roy, Jahnabi; Burke, Martin D

2014-06-01

The inherent modularity of polypeptides, oligonucleotides and oligosaccharides has been harnessed to achieve generalized synthesis platforms. Importantly, like these other targets, most small-molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This suggests that many small molecules also possess inherent modularity commensurate with systematic building block-based construction. Supporting this hypothesis, here we report that the polyene motifs found in >75% of all known polyene natural products can be synthesized using just 12 building blocks and one coupling reaction. Using the same general retrosynthetic algorithm and reaction conditions, this platform enabled both the synthesis of a wide range of polyene frameworks that covered all of this natural-product chemical space and the first total syntheses of the polyene natural products asnipyrone B, physarigin A and neurosporaxanthin b-D-glucopyranoside. Collectively, these results suggest the potential for a more generalized approach to making small molecules in the laboratory.

Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction

NASA Astrophysics Data System (ADS)

Woerly, Eric M.; Roy, Jahnabi; Burke, Martin D.

2014-06-01

The inherent modularity of polypeptides, oligonucleotides and oligosaccharides has been harnessed to achieve generalized synthesis platforms. Importantly, like these other targets, most small-molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This suggests that many small molecules also possess inherent modularity commensurate with systematic building block-based construction. Supporting this hypothesis, here we report that the polyene motifs found in >75% of all known polyene natural products can be synthesized using just 12 building blocks and one coupling reaction. Using the same general retrosynthetic algorithm and reaction conditions, this platform enabled both the synthesis of a wide range of polyene frameworks that covered all of this natural-product chemical space and the first total syntheses of the polyene natural products asnipyrone B, physarigin A and neurosporaxanthin β-D-glucopyranoside. Collectively, these results suggest the potential for a more generalized approach to making small molecules in the laboratory.

Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design.

PubMed

Okesola, Babatunde O; Mata, Alvaro

2018-05-21

Nature is enriched with a wide variety of complex, synergistic, and highly functional protein-based multicomponent assemblies. As such, nature has served as a source of inspiration for using multicomponent self-assembly as a platform to create highly ordered, complex, and dynamic protein and peptide-based nanostructures. Such an assembly system relies on the initial interaction of distinct individual building blocks leading to the formation of a complex that subsequently assembles into supramolecular architectures. This approach not only serves as a powerful platform for gaining insight into how proteins co-assemble in nature but also offers huge opportunities to harness new properties not inherent in the individual building blocks. In the past decades, various multicomponent self-assembly strategies have been used to extract synergistic properties from proteins and peptides. This review highlights the updates in the field of multicomponent self-assembly of proteins and peptides and summarizes various strategies, including covalent conjugation, ligand-receptor interactions, templated/directed assembly and non-specific co-assembly, for driving the self-assembly of multiple proteins and peptide-based building blocks into functional materials. In particular, we focus on peptide- or protein-containing multicomponent systems that, upon self-assembly, enable the emergence of new properties or phenomena. The ultimate goal of this review is to highlight the importance of multicomponent self-assembly in protein and peptide engineering, and to advocate its growth in the fields of materials science and nanotechnology.

Improvement of a block co-polymer (PS-b-PDMS) template etch profile using amorphous carbon layer

NASA Astrophysics Data System (ADS)

Oh, JiSoo; Oh, Jong Sik; Sung, DaIn; Yim, SoonMin; Song, SeungWon; Yeom, GeunYoung

2017-03-01

Block copolymers (BCPs) are consisted of at least two types of monomers which have covalent bonding. One of the widely investigated BCPs is polystyrene-block-polydimethylsiloxane (PS-b-PDMS), which is used as an alternative patterning method for various deep nanoscale devices due to its high Flory-Huggins interaction parameter (χ), such as optical devices and transistors, replacing conventional photolithography. As an alternate or supplementary nextgeneration lithography technology to extreme ultraviolet lithography (EUVL), BCP lithography utilizing the DSA of BCP has been actively studied. However, the nanoscale BCP mask material is easily damaged by the plasma and has a very low etch selectivity over bottom semiconductor materials, because it is composed of polymeric materials even though it contains Si in PDMS. In this study, an amorphous carbon layer (ACL) was inserted as a hardmask material between BCP and materials to be patterned, and, by using O2 plasmas, the characteristics of dry etching of ACL for high aspect ratio (HAR) using a 10 nm PDMS pattern were investigated. The results showed that, by using a PS-b-PDMS pattern with an aspect ratio of 0.3 0.9:1, a HAR PDMS/ACL double layer mask with an aspect ratio of 10:1 could be fabricated. In addition, by the optimization of the plasma etch process, ACL masks with excellent sidewall roughness (SWR,1.35 nm) and sidewall angle (SWA, 87.9˚) could be fabricated.

Synthesis of most polyene natural product motifs using just twelve building blocks and one coupling reaction

PubMed Central

Woerly, Eric M.; Roy, Jahnabi; Burke, Martin D.

2014-01-01

The inherent modularity of polypeptides, oligonucleotides, and oligosaccharides has been harnessed to achieve generalized building block-based synthesis platforms. Importantly, like these other targets, most small molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This suggests that many small molecules also possess inherent modularity commensurate with systematic building block-based construction. Supporting this hypothesis, here we report that the polyene motifs found in >75% of all known polyene natural products can be synthesized using just 12 building blocks and one coupling reaction. Using the same general retrosynthetic algorithm and reaction conditions, this platform enabled the synthesis of a wide range of polyene frameworks covering all of this natural product chemical space, and first total syntheses of the polyene natural products asnipyrone B, physarigin A, and neurosporaxanthin β-D-glucopyranoside. Collectively, these results suggest the potential for a more generalized approach for making small molecules in the laboratory. PMID:24848233

Investigation of Crew Restraint System Biomechanics.

DTIC Science & Technology

1982-05-01

46FAMRL-TR-81 -103 SINVESTIGATION OF CREW RESTRAINT SYSTEM BIOMECHANICS NORMWAN S. PHILLIPS ROBERT A. THOMSON IRA B. FISCUS UNIVERSITY OF DA YTON RESEARCH...Escape System Biomechanics 20. ABSTRACT (Continue on reverse side If necessary and identify by block number) .Experimental data were collected and...properties and harness characteristics were included in the model. The analytical model was also used with biomechanical data for the rhesus monkey

Right-Sizing Intervention: The Philippines, El Salvador, and the Future of American Foreign Internal Defense

DTIC Science & Technology

2013-06-01

version of the title Hukbong Bayan Laban sa Hapon, or “People’s Anti- Japanese Army.” The Hukbalahap originated as a resistance movement during the... Japanese occupation, but continued to fight against the government, primarily over land-tenancy issues that will be detailed in chapter four. 5 Like...The Uses and Limits of Small Scale Military Interventions, 23. 25 This critique even has an analogue in fiction and cinema . See The Quiet

Southeastward increase of the late Quaternary slip-rate of the Xianshuihe fault, eastern Tibet. Geodynamic and seismic hazard implications

NASA Astrophysics Data System (ADS)

Bai, Mingkun; Chevalier, Marie-Luce; Pan, Jiawei; Replumaz, Anne; Leloup, Philippe Hervé; Métois, Marianne; Li, Haibing

2018-03-01

The left-lateral strike-slip Xianshuihe fault system located in the eastern Tibetan Plateau is considered as one of the most tectonically active intra-continental fault system in China, along which more than 20 M > 6.5 and more than 10 M > 7 earthquakes occurred since 1700. Therefore, studying its activity, especially its slip rate at different time scales, is essential to evaluate the regional earthquake hazard. Here, we focus on the central segment of the Xianshuihe fault system, where the Xianshuihe fault near Kangding city splays into three branches: the Selaha, Yalahe and Zheduotang faults. In this paper we use precise dating together with precise field measurements of offsets to re-estimate the slip rate of the fault that was suggested without precise age constraints. We studied three sites where the active Selaha fault cuts and left-laterally offsets moraine crests and levees. We measured horizontal offsets of 96 ± 20 m at Tagong levees (TG), 240 ± 15 m at Selaha moraine (SLH) and 80 ± 5 m at Yangjiagou moraine (YJG). Using 10Be cosmogenic dating, we determined abandonment ages at Tagong, Selaha and Yangjiagou of 12.5 (+ 2.5 / - 2.2) ka, 22 ± 2 ka, and 18 ± 2 ka, respectively. By matching the emplacement age of the moraines or levees with their offsets, we obtain late Quaternary horizontal average slip-rates of 7.6 (+ 2.3 / - 1.9) mm/yr at TG and 10.7 (+ 1.3 / - 1.1) mm/yr at SLH, i.e., 5.7-12 mm/yr or between 9.6 and 9.9 mm/yr assuming that the slip rate should be constant between the nearby TG and SLH sites. At YJG, we obtain a lower slip rate of 4.4 ± 0.5 mm/yr, most likely because the parallel Zheduotang fault shares the slip rate at this longitude, therefore suggesting a ∼5 mm/yr slip rate along the Zheduotang fault. The ∼10 mm/yr late Quaternary rate along the Xianshuihe fault is higher than that along the Ganzi fault to the NW (6-8 mm/yr). This appears to be linked to the existence of the Longriba fault system that separates the Longmenshan and Bayan Har blocks north of the Xianshuihe fault system. A higher slip rate along the short (∼60 km) and discontinuous Selaha fault compared to that along the long (∼300 km) and linear Ganzi fault suggests a high hazard for a M > 6 earthquake in the Kangding area in the near future, which could devastate that densely populated city.

A new Triassic shortening-extrusion tectonic model for Central-Eastern Asia: Structural, geochronological and paleomagnetic investigations in the Xilamulun Fault (North China)

NASA Astrophysics Data System (ADS)

Zhao, Pan; Faure, Michel; Chen, Yan; Shi, Guanzhong; Xu, Bei

2015-09-01

At the northern margin of the North China Block (NCB), the Xilamulun Fault (XMF) is a key belt to decipher the tectonic evolution of Central-Eastern Asia, as it records the Paleozoic final closure of the Paleo-Asian Ocean, and localizes a Late Triassic intracontinental deformation. In this study, structural analysis, 40Ar-39Ar dating, and paleomagnetic studies were performed to investigate the kinematics of the XMF and to further discuss its Triassic geodynamic significance in the Central-Eastern Asia framework after the Paleozoic Central Asian Orogenic evolution. The structural analyses reveal two phases of ductile deformation. The first one (D1), which displays N-verging and E-W trending folds, is related to the Early Paleozoic collisional event between the NCB and the Songliao-Hunshandake Block (SHB). The second phase (D2) displays a high-angle foliation and a pervasive sub-horizontal E-W stretching lineation with kinematic criteria indicative of dextral strike-slip shearing. The 40Ar-39Ar dating on mylonitic granite places the main shearing event around 227-209 Ma. This D2 shearing is coeval with that of the dextral strike-slip Bayan Obo-Chifeng Fault (BCF) and the Chicheng-Fengning-Longhua Fault to the south, which together constitute a dextral shearing fault system on the northern margin of the NCB during the Late Triassic. The paleomagnetic study performed on the Middle Permian Guangxingyuan pluton, located between the XMF and BCF, documents a local clockwise rotation of this pluton with respect to the NCB and SHB. Our multidisciplinary study suggests an NNW-SSE shortening and strike-slip shearing dominated tectonic setting on the northern margin of the NCB during the Late Triassic. Combining the contemporaneous dextral strike-slip movements of the XMF and BCF in northern China and the sinistral strike-slip movement of East Gobi Fault (EGF) in southeastern Mongolia with the large-scale tectonic framework, a Late Triassic NNW-SSE shortening-eastward extrusion tectonic model for Central-Eastern Asia is firstly proposed. The NNW-SSE shortening results in the eastward extrusion of the continental wedge bounded by the BCF and EGF, which is accommodated by the different kinematic patterns of the southern (XMF and BCF) and northwestern (EGF) bounding faults. This shortening-extrusion tectonic framework is tentatively interpreted as the result of the far field forces associated with three Late Triassic lithosphere-scale convergences in East Asia: i) northward intracontinental subduction between the NCB and South China Block, ii) collision of the Qiangtang Block with the Qaidam Block, and iii) southward subduction of the Mongol-Okhotsk Ocean beneath the Mongolia Block.

A new Triassic shortening-extrusion tectonic model for Central-EasternAsia: Structural, geochronological and paleomagnetic investigations in the Xilamulun Fault (North China)

NASA Astrophysics Data System (ADS)

Zhao, Pan; Faure, Michel; Chen, Yan; Xu, Bei

2017-04-01

At the northern margin of the North China Block (NCB), the Xilamulun Fault (XMF) is a key belt to decipher the tectonic evolution of Central-Eastern Asia, as it records the Paleozoic final closure of the Paleo-Asian Ocean, and localizes a Late Triassic intracontinental deformation. In this study, structural analysis, 40Ar-39Ar dating, and paleomagnetic studies were performed to investigate the kinematics of the XMF and to further discuss its Triassic geodynamic significance in the Central-Eastern Asia framework after the Paleozoic Central Asian Orogenic evolution. The structural analyses reveal two phases of ductile deformation. The first one (D1), which displays N-verging and E-W trending folds, is related to the Early Paleozoic collisional event between the NCB and the Songliao-Hunshandake Block (SHB). The second phase (D2) displays a high-angle foliation and a pervasive sub-horizontalE-W stretching lineation with kinematic criteria indicative of dextral strike-slip shearing. The 40Ar-39Ar dating on mylonitic granite places the main shearing event around 227-209 Ma. This D2 shearing is coeval with that of the dextral strike-slip Bayan Obo-Chifeng Fault (BCF) and the Chicheng-Fengning-Longhua Fault to the south, which together constitute a dextral shearing fault system on the northern margin of the NCB during the Late Triassic. The paleomagnetic study performed on the Middle Permian Guangxingyuan pluton, located between the XMF and BCF, documents a local clockwise rotation of this pluton with respect to the NCB and SHB. Our multidisciplinary study suggests anNNW-SSE shortening and strike-slip shearing dominated tectonic setting on the northern margin of the NCB during the Late Triassic. Combining the contemporaneous dextral strike-slip movements of the XMF and BCF in northern China and the sinistral strike-slip movement of East Gobi Fault (EGF) in southeastern Mongolia with the large-scale tectonic framework, a Late Triassic NNW-SSE shortening-eastward extrusion tectonic model for Central-Eastern Asia is firstly proposed. The NNW-SSE shortening results in the eastward extrusion of the continental wedge bounded by the BCF and EGF, which is accommodated by the different kinematic patterns of the southern (XMF and BCF) and northwestern (EGF) bounding faults. This shortening-extrusion tectonic framework is tentatively interpreted as the result of the far field forces associated with three Late Triassic lithosphere-scale convergences in East Asia: i)northward intracontinental subduction between the NCB and South China Block, ii)collision of the Qiangtang Block with the Qaidam Block, and iii)southward subduction of the Mongol-Okhotsk Ocean beneath the Mongolia Block.

Anomalous abundance and redistribution patterns of rare earth elements in soils of a mining area in Inner Mongolia, China.

PubMed

Wang, Lingqing; Liang, Tao

2016-06-01

The Bayan Obo Mine, the largest rare earth element (REE) deposit ever found in the world, has been mined for nearly 60 years for iron and rare earth elements. To assess the influences of mining activities on geochemical behavior of REEs in soils, 27 surface soil samples and three soil profile samples were collected from different directions in the vicinity of the mine area. The total concentrations of REEs in surface soils varied from 149.75 to 18,891.81 mg kg(-1) with an average value of 1906.12 mg kg(-1), which was apparently higher than the average values in China (181 mg kg(-1)). The order of the average concentrations of individual REEs in surface soils was similar to that in Bayan Obo ores, which confirmed that the concentration and distribution of REEs in the soils was influenced by the mining activities. The concentrations of single REE in the soil profiles showed a similar trend with depth with an increase at 0-25 cm section, then decreased and remained relatively stable in the deep part. The normalized curves inclined to the right side, showing the conspicuous fractionation between the light and heavy REEs, which supported by the North American Shale Composite (NASC) and Post-Archean Australian Shale (PAAS) normalized concentration ratios calculated for selected elements (La N /Yb N , La N /Sm N , Gd N /Yb N ). Slight positive Ce anomaly and negative Eu anomaly were also observed.

Safety Assessment of TACOM’s Ride Motion Simulator

DTIC Science & Technology

1990-01-24

level (1300 to 1800 psi). 24 Step 16. Pressurize the system by moving the main pressure switch to "ON." Wait for the roll, pitch, and yaw error signals...the appropriate seat/shoulder/safety belts and harnesses. Carefully, help the test subject dismount. Step 41. Flip the main pressure switch on the...Dismount the test subject. Step 6. Move the main pressure switch to the "OFF" position. This will block any hydraulic flow to the system. Step 7. Move the

Summary of the Ahankashan Area of Interest

USGS Publications Warehouse

Drew, Lawrence J.; Sutphin, David M.; Mars, John C.; Bogdanow, Anya K.

2015-09-15

This report summarizes and interprets results of the work in the Ahankashan Area of Interest in northwestern Afghanistan and four study areas—the Ahankashan Prospect Area, Syahsang-Kushkak, Taghab-Soni, and Zakak-e ‘Olya—delineated for their potential undiscovered mineral occurrences with specific emphasis on porphyry copper and related occurrence types. The Area of Interest is underlain by rocks of three different geologic domains that cross from east to west—the Band-e-Bayan Block/Central Pamirs Domain in the south, the Hindu Kush Domain in the Paropamisus Mountains, and the Afghan Turkestan Domain in the north. The domains are sutured remnants of Tethyan tectonic elements. Interpretation of the geologic maps indicates the presence of thrust faults, strike-slip faults, and granitic intrusions emplaced in ground prepared by faulting. Thrust faulting was followed by strike-slip faulting and then followed by magmatic intrusions. Advanced Spaceborne Thermal Emission and Reflection Radiometer data were used to map minerals that have been altered by hydrothermal fluids typically associated with mineralization to delineate new potential occurrences of copper, gold, and silver. Propylitic-, argillic-, and phyllic-altered intrusive rocks are found in the area, as well as very minor amounts of hydrothermal silica-rich rocks. This area of interest is vastly underexplored and contains only seven known mineral occurrences, of which the Ahankashan copper (gold) skarn occurrence is the best known. Gold has been found in stream sediments near the Ahankashan skarn, in the Taghab-Soni study area, and possibly other parts of the Area of Interest, suggesting potential for at least small-scale placer occurrences.

Testing an attachment method for solar-powered tracking devices on a long-distance migrating shorebird

USGS Publications Warehouse

Chan, Ying-Chi; Brugge, Martin; Tibbitts, T. Lee; Dekinga, Anne; Porter, Ron; Klaassen, Raymond H. G.; Piersma, Theunis

2016-01-01

Small solar-powered satellite transmitters and GPS data loggers enable continuous, multi-year, and global tracking of birds. What is lacking, however, are reliable methods to attach these tracking devices to small migratory birds so that (1) flight performance is not impacted and (2) tags are retained during periods of substantial mass change associated with long-distance migration. We developed a full-body harness to attach tags to Red Knots (Calidris canutus), a medium-sized shorebird (average mass 124 g) that undertakes long-distance migrations. First, we deployed dummy tags on captive birds and monitored them over a complete migratory fattening cycle (February–July 2013) during which time they gained and lost 31–110 g and underwent a pre-alternate moult of body feathers. Using each individual’s previous year fattening and moult data in captivity as controls, we compared individual mass and moult differences between years between the tagged and reference groups, and concluded that the attachment did not impact mass and moult cycles. However, some birds shed feathers under the tags and under the polyester harness line commonly used in avian harnesses. Feather shedding was alleviated by switching to smoothed-bottom tags and monofilament harness lines. To field-trial this design, we deployed 5-g satellite transmitters on ten Red Knots released on 3 October 2013 in the Dutch Wadden Sea. Bird movements and tag performance appeared normal. However, nine tags stopped transmitting 11–170 days post-release which was earlier than expected. We attribute this to bird mortality rather than failure of the attachments or transmitters and suggest that the extra weight and drag caused by the tag and its feather-blocking shield increased the chance of depredation by the locally common Peregrine Falcons (Falco peregrinus). Our results demonstrate that species- and place-specific contexts can strongly determine tagging success. While captive trials are an important first step in developing an attachment method, field trials are essential to fully assess attachment designs.

KRAS as a Therapeutic Target.

PubMed

McCormick, Frank

2015-04-15

KRAS proteins play a major role in human cancer, but have not yielded to therapeutic attack. New technologies in drug discovery and insights into signaling pathways that KRAS controls have promoted renewed efforts to develop therapies through direct targeting of KRAS itself, new ways of blocking KRAS processing, or by identifying targets that KRAS cancers depend on for survival. Although drugs that block the well-established downstream pathways, RAF-MAPK and PI3K, are being tested in the clinic, new efforts are under way to exploit previously unrecognized vulnerabilities, such as altered metabolic networks, or novel pathways identified through synthetic lethal screens. Furthermore, new ways of suppressing KRAS gene expression and of harnessing the immune system offer further hope that new ways of treating KRAS are finally coming into view. These issues are discussed in this edition of CCR Focus. ©2015 American Association for Cancer Research.

Redox Catalysis Facilitates Lignin Depolymerization

PubMed Central

2017-01-01

Lignin is a recalcitrant and underexploited natural feedstock for aromatic commodity chemicals, and its degradation generally requires the use of high temperatures and harsh reaction conditions. Herein we present an ambient temperature one-pot process for the controlled oxidation and depolymerization of this potent resource. Harnessing the potential of electrocatalytic oxidation in conjugation with our photocatalytic cleavage methodology, we have developed an operationally simple procedure for selective fragmentation of β-O-4 bonds with excellent mass recovery, which provides a unique opportunity to expand the existing lignin usage from energy source to commodity chemicals and synthetic building block source. PMID:28691074

Flight performance, energetics and water turnover of tippler pigeons with a harness and dorsal load

USGS Publications Warehouse

Gessaman, J.A.; Workman, G.W.; Fuller, M.R.

1991-01-01

We measured carbon dioxide production and water efflux of 12 tippler pigeons (Columba spp.) during seven experimental flights using the doubly labeled water (DLW) method. Prior to the experiment birds were randomly assigned to one of two groups. One group flew as controls (no load or harness) on all seven flights. The other group wore a harness on two flights, a dorsal load/harness package (weighing about 5% of a bird's mass) on two flights, and they were without a load in three flights. Flight duration of pigeons with only a harness and with a dorsal load/harness package was 21 and 26% less, respectively, than the controls. Pigeons wearing a harness, or wearing a dorsal load/harness package lost water 50-90%, and 57-100% faster, respectively, than control pigeons. The mean CO2 production of pigeons wearing a harness or a load/harness package was not significantly different than pigeons without a harness or load. The small sample sizes and large variability in DLW measuremets precluded a good test of the energetic cost of flying with a harness and dorsal load.

Flight performance energetics and water turnovers of Tippler Pigeons with a harness and doorsal load

USGS Publications Warehouse

Gessaman, James A.; Workman, Gar W.; Fuller, Mark R.

1991-01-01

We measured carbon dioxide production and water efflux of 12 tippler pigeons (Columba spp.) during seven experimental flights using the doubly labeled water (DLW) method. Prior to the experiment birds were randomly assigned to one of two groups. One group flew as controls (no load or harness) on all seven flights. The other group wore a harness on two flights, a dorsal load/harness package (weighing about 5% of a birda??s mass) on two flights, and they were without a load in three flights. Plight duration of pigeons with only a harness and with a dorsal load/harness package was 21 and 26% less, respectively, than the controls. Pigeons wearing a harness, or wearing a dorsal load/harness package lost water 50-90%, and 57-100% faster, respectively, than control pigeons. The mean CO, production of pigeons wearing a harness or a load/harness package was not significantly different than pigeons without a harness or load. The small sample sizes and large variability in DLW measurements precluded a good test of the energetic cost of flying with a harness and dorsal load.

Stationary and non-stationary extreme value modeling of extreme temperature in Malaysia

NASA Astrophysics Data System (ADS)

Hasan, Husna; Salleh, Nur Hanim Mohd; Kassim, Suraiya

2014-09-01

Extreme annual temperature of eighteen stations in Malaysia is fitted to the Generalized Extreme Value distribution. Stationary and non-stationary models with trend are considered for each station and the Likelihood Ratio test is used to determine the best-fitting model. Results show that three out of eighteen stations i.e. Bayan Lepas, Labuan and Subang favor a model which is linear in the location parameter. A hierarchical cluster analysis is employed to investigate the existence of similar behavior among the stations. Three distinct clusters are found in which one of them consists of the stations that favor the non-stationary model. T-year estimated return levels of the extreme temperature are provided based on the chosen models.

Application of Markov chain model to daily maximum temperature for thermal comfort in Malaysia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nordin, Muhamad Asyraf bin Che; Hassan, Husna

2015-10-22

The Markov chain’s first order principle has been widely used to model various meteorological fields, for prediction purposes. In this study, a 14-year (2000-2013) data of daily maximum temperatures in Bayan Lepas were used. Earlier studies showed that the outdoor thermal comfort range based on physiologically equivalent temperature (PET) index in Malaysia is less than 34°C, thus the data obtained were classified into two state: normal state (within thermal comfort range) and hot state (above thermal comfort range). The long-run results show the probability of daily temperature exceed TCR will be only 2.2%. On the other hand, the probability dailymore » temperature within TCR will be 97.8%.« less

Ada (Trade Name) Compiler Validation Summary Report: Harris Corporation. Harris Ada Compiler, Version 3.1. Harris H1200.

DTIC Science & Technology

1987-06-03

F TADADS I 3- bi. I A - I EEOM "O.VPAGE:N(..4-A I . RE 12. GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER 4. TITLE (andSubtitle) 5. TYPE OF REPORT...reverse side if necessary and identify by block number) See Attached / 1 DD 10"m 1473 EDITION OF I NOV 65 IS OBSOLETE 1 JAN 73 S/N 0102-LF-014-6601...States Government (Ada Joint Program Office). i 4 AVF Control Number: AVF-VSR-8C.0787 87-01 -07-HAR Ada® COMPILER VALIDATION SUMMARY REPORT: Harris

The Optical Harness: a light-weight EMI-immune replacement for legacy electrical wiring harnesses

NASA Astrophysics Data System (ADS)

Stark, Jason B.; Jackson, B. Scott; Trethewey, William

2006-05-01

Electrical wiring harnesses have been used to interconnect control and communication equipment in mobile platforms for over a century. Although they have served this function successfully, they have three problems that are inherent in their design: they are mechanically heavy and stiff, and they are prone to electrical faults, including arcing and Electro-Magnetic Interference (EMI), and they are difficult to maintain when faults occur. These properties are all aspects of the metallic conductors used to build the harnesses. The Optical Harness TM is a photonic replacement for the legacy electrical wiring harness. The Optical Harness TM uses light-weight optical fiber to replace signal wires in an electrical harness. The original electrical connections to the equipment remain, making the Optical Harness TM a direct replacement for the legacy wiring harness. In the backshell of each connector, the electrical signals are converted to optical, and transported on optical fiber, by a deterministic, redundant and fault-tolerant optical network. The Optical Harness TM: * Provides weight savings of 40-50% and unsurpassed flexibility, relative to legacy signal wiring harnesses; * Carries its signals on optical fiber that is free from arcing, EMI, RFI and susceptibility to HPM weapons; * Is self-monitoring during operation, providing non-intrusive predictive and diagnostic capabilities.

On-Orbit Evaluation of a New Treadmill Harness for Improved Crewmember Comfort and Load Distribution

NASA Technical Reports Server (NTRS)

Perusek, G. P.; Sheehan, C. C.; Savina, M. C.; Owings, T. M.; Davis, B. L.; Ryder, J. W.

2011-01-01

The current design of the International Space Station (ISS) Treadmill Harness has been reported to cause pain and discomfort to crewmembers during exercise. The Harness Station Development Test Objective (SDTO) provided participating crewmembers (n = 6) with a new harness design, the "Glenn Harness," to evaluate for comfort and loading as compared to the current Treadmill Harness. A novel suite of load-sensing instrumentation was developed to noninvasively measure load distribution and provided a first-ever quantification of actual dynamic loads during treadmill exercise. In addition, crew debriefs provided feedback on harness preference and overall impressions. Conclusions: Post-flight analysis in returned Glenn Harnesses (n = 3) showed minimal wear and tear. Four of the six subjects found the Glenn Harness to be more comfortable in this on-orbit, side-by-side comparison as measured by the crew comfort questionnaire and crew debriefs. Specific areas for improvement have been identified, and forward recommendations will be provided to the Human Research Program. The protocol developed for the SDTO provided valuable insight into crew comfort issues, design improvements, and loading preferences for exercise harnessing, which lays the groundwork for better harnessing systems and training protocols.

Chloroquine Engages the Immune System to Eradicate Irradiated Breast Tumors in Mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratikan, Josephine Anna; Sayre, James William; Schaue, Dörthe, E-mail: dschaue@mednet.ucla.edu

2013-11-15

Purpose: This study used chloroquine to direct radiation-induced tumor cell death pathways to harness the antitumor activity of the immune system. Methods and Materials: Chloroquine given immediately after tumor irradiation increased the cure rate of MCaK breast cancer in C3H mice. Chloroquine blocked radiation-induced autophagy and drove MCaK cells into a more rapid apoptotic and more immunogenic form of cell death. Results: Chloroquine treatment made irradiated tumor vaccines superior at inducing strong interferon gamma-associated immune responses in vivo and protecting mice from further tumor challenge. In vitro, chloroquine slowed antigen uptake and degradation by dendritic cells, although T-cell stimulation wasmore » unaffected. Conclusions: This study illustrates a novel approach to improve the efficacy of breast cancer radiation therapy by blocking endosomal pathways, which enhances radiation-induced cell death within the field and drives antitumor immunity to assist therapeutic cure. The study illuminates and merges seemingly disparate concepts regarding the importance of autophagy in cancer therapy.« less

Integration of a Copper-Containing Biohybrid (CuHARS) with Cellulose for Subsequent Degradation and Biomedical Control

PubMed Central

Karan, Anik; Darder, Margarita; Kansakar, Urna; Norcross, Zach

2018-01-01

We previously described the novel synthesis of a copper high-aspect ratio structure (CuHARS) biohybrid material using cystine. While extremely stable in water, CuHARS is completely (but slowly) degradable in cellular media. Here, integration of the CuHARS into cellulose matrices was carried out to provide added control for CuHARS degradation. Synthesized CuHARS was concentrated by centrifugation and then dried. The weighed mass was re-suspended in water. CuHARS was stable in water for months without degradation. In contrast, 25 μg/mL of the CuHARS in complete cell culture media was completely degraded (slowly) in 18 days under physiological conditions. Stable integration of CuHARS into cellulose matrices was achieved through assembly by mixing cellulose micro- and nano-fibers and CuHARS in an aqueous (pulp mixture) phase, followed by drying. Additional materials were integrated to make the hybrids magnetically susceptible. The cellulose-CuHARS composite films could be transferred, weighed, and cut into usable pieces; they maintained their form after rehydration in water for at least 7 days and were compatible with cell culture studies using brain tumor (glioma) cells. These studies demonstrate utility of a CuHARS-cellulose biohybrid for applied applications including: (1) a platform for biomedical tracking and (2) integration into a 2D/3D matrix using natural products (cellulose). PMID:29693569

75 FR 63422 - Airworthiness Directives; Embraer-Empresa Brasileira de Aeronautica S.A. Model EMB-500 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... chafing between the same harness and the oxygen tubing. The chafing of the wiring harness against the oxygen tubing could lead to a short circuit of the wiring harness and a subsequent fire in the airplane... harness and the oxygen tubing. The chafing of the wiring harness against the oxygen tubing could lead to a...

Behavior of sandhill cranes harnessed with different satellite transmitters

USGS Publications Warehouse

Olsen, Glenn H.; Ellis, D.H.; Landfried, S.E.; Miller, L.H.; Klugman, S.S.; Fuller, M.R.; Vermillion, C.H.

1992-01-01

The effectiveness of various attachment methods and designs of platform transmitting terminals (PTT's) was tested on captive sandhill cranes (Grus canadensis) at the Patuxent Wildlife Research Center, Laurel, Maryland, during 1989-91. Combinations of attachment and transmitter designs included neoprene cord harness with batteries separate from the transmitter (2 harness designs), Teflon ribbon harness with batteries incorporated into the transmitter package (4 transmitter models), and a package attached directly to the bird with epoxy glue only. Physical effects seen on cranes wearing PTT's ranged from skin lacerations (caused by rubbing of harness material) to no observed effects (other than feather wear). The most successful harness material and design utilized a Teflon ribbon harness with the 4 ribbon ends from the transmitter forming a neck loop and a body loop joined at the sternum. Time spent by sandhill cranes performing most activities did not change after transmitter attachment using this harness method.

Intelligent electrical harness connector assembly using Bell Helicopter Textron's 'Wire Harness Automated Manufacturing System'

NASA Astrophysics Data System (ADS)

Springer, D. W.

Bell Helicopter Textron, Incorporated (BHTI) installed two Digital Equipment Corporation PDP-11 computers and an American Can Inc. Ink Jet printer in 1980 as the cornerstone of the Wire Harness Automated Manufacturing System (WHAMS). WHAMS is based upon the electrical assembly philosophy of continuous filament harness forming. This installation provided BHTI with a 3 to 1 return-on-investment by reducing wire and cable identification cycle time by 80 percent and harness forming, on dedicated layout tooling, by 40 percent. Yet, this improvement in harness forming created a bottle neck in connector assembly. To remove this bottle neck, BHTI has installed a prototype connector assembly cell that integrates the WHAMS' data base and innovative computer technologies to cut harness connector assembly cycle time. This novel connector assembly cell uses voice recognition, laser identification, and animated computer graphics to help the electrician in the correct assembly of harness connectors.

Miniature Release Mechanism or Diminutive Assembly for Nanosatellite Deployables (DANY)

NASA Technical Reports Server (NTRS)

Santos Soto, Luis H. (Inventor); Hesh, Scott V. (Inventor); Hudeck, John D. (Inventor)

2017-01-01

Miniature release mechanisms constrain objects, such as deployables during the launch of space vehicles, such as small satellites and nanosatellites, and enable the release of the objects once a desired destination is reached by the space vehicle. Constraint and release of the objects are achieved by providing a secure threaded interface that may be released by the release mechanisms. The release mechanisms include a housing structure; a release block can include a threaded interface; one or more retracting pins; one or more release springs; a breakable link, such as a plastic link; a cable harness clamp; and a circuit board. The release mechanism can be 0.1875 inches (approximately 4.8 mm) thick.

Arresting Evolution.

PubMed

Bull, James J; Barrick, Jeffrey E

2017-12-01

Evolution in the form of selective breeding has long been harnessed as a useful tool by humans. However, rapid evolution can also be a danger to our health and a stumbling block for biotechnology. Unwanted evolution can underlie the emergence of drug and pesticide resistance, cancer, and weeds. It makes live vaccines and engineered cells inherently unreliable and unpredictable, and therefore potentially unsafe. Yet, there are strategies that have been and can possibly be used to stop or slow many types of evolution. We review and classify existing population genetics-inspired methods for arresting evolution. Then, we discuss how genome editing techniques enable a radically new set of approaches to limit evolution. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Negative Rotation Cinch Strap.

DTIC Science & Technology

This project discloses an improved unitary parachute torso harness, having a single fastening means, wherein an auxillary tightening strap is...attached to the groin straps of said harness. Said auxillary straps are used to prevent torso rotation or harness slippage and to prevent harness elongation

Moving Large Wiring-Harness Boards

NASA Technical Reports Server (NTRS)

Shepherd, Samuel D.; Gurman, Isaac

1990-01-01

Carrier for wiring-harness fabrication boards enables lone operator to move board easily and safely. Holds harness while operator fabricating, while being stored, and being transported to equipment frame for mounting. When positioned for assembly of wiring harness, board and carrier give operator easy and convenient access to wires and cables, when positioned for transfer of wiring harness to or from storage area, carrier holds board securely while moved by one person.

14 CFR 125.211 - Seat and safety belts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... emergency exit. (f) Each occupant of a seat equipped with a shoulder harness must fasten the shoulder harness during takeoff and landing, except that, in the case of crewmembers, the shoulder harness need not be fastened if the crewmember cannot perform his required duties with the shoulder harness fastened...

Which is the better forecasting model? A comparison between HAR-RV and multifractality volatility

NASA Astrophysics Data System (ADS)

Ma, Feng; Wei, Yu; Huang, Dengshi; Chen, Yixiang

2014-07-01

In this paper, by taking the 5-min high frequency data of the Shanghai Composite Index as example, we compare the forecasting performance of HAR-RV and Multifractal volatility, Realized volatility, Realized Bipower Variation and their corresponding short memory model with rolling windows forecasting method and the Model Confidence Set which is proved superior to SPA test. The empirical results show that, for six loss functions, HAR-RV outperforms other models. Moreover, to make the conclusions more precise and robust, we use the MCS test to compare the performance of their logarithms form models, and find that the HAR-log(RV) has a better performance in predicting future volatility. Furthermore, by comparing the two models of HAR-RV and HAR-log(RV), we conclude that, in terms of performance forecasting, the HAR-log(RV) model is the best model among models we have discussed in this paper.

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

Application of a modified harness design for attachment of radio transmitters to shorebirds

USGS Publications Warehouse

Sanzenbacher, Peter M.; Haig, Susan M.; Oring, Lewis W.

2000-01-01

Radio transmitter attachment methodology is important to the design of radio telemetry studies. In 1998, we attached 5 transmitters to a captive population of Western Sandpipers (Calidris mauri) and 7 transmitters to wild Killdeer (Charadriusv ociferus) using a modified version of the Rappole and Tipton (1991) figure-8 leg-loop harness. Captive birds fitted with harnesses did not exhibit quantifiable differences in behavior relative to control birds. Based on initial success in using the leg-loop harnesses, we used harnesses to attach transmitters in the wild to 30 Killdeer and 49 Dunlin (Calidris alpina) during the winters of 1998-1999 and 1999-2000. This was part of a study on movements of wintering shorebirds in the Willamette Valley of Oregon, USA. Wild birds showed no adverse effects of the harnesses.Thus, the described harness is a practical method for attachment of transmitters to shorebirds. Advantages of this harness method include a reduction in handling time at capture, elimination of the need to clip feathers for attachment, and increased transmitter retention time.

[Vascular thrombosis and pulmonary thrombo-embolism due to harness suspension].

PubMed

Pisati, G; Cerri, S; Achille, G; Rossi, G; Lorenzi, G

2007-01-01

In many sports (such as rock-climbing and caving) and working activities (e.g., construction and maintenance of buildings, pruning of lung-trunked trees, abseiling in wells) people run the risk of falling from a height. To prevent the effects of any potential fall, personalprotection devices consisting of at least a body holding device (i.e. a harness of some type), a lanyard and a reliable anchor are used. Reporting on the occurrence of vascular thrombosis in subjects undergoing prolonged hanging in a harness, either for work or recreation. We investigated patients treated for vascular thrombosis in our hospital in the last 5 years to identify subjects with frequent use of a harness. We identified a 36-year-old rock-climber who developed pulmonary thrombo-embolism and infarction 5 days after he had been wearing a harness for 12 hours consecutively, and a 32 year-old worker who often used a harness to fix wire-nettings to prevent rocks falling from steep places and suffered thrombosis of the left superficial femoral artery. A feature of both cases was the considerable length of time spent hanging in the harness and the absence of alternative risk factors for thrombosis. Prolonged hanging in a harness can be dangerous in itself because it can produce vascular thrombosis. Reduction of intravascular blood flow (stasis) and compression of the femoral veins by harness groin straps were the likely pathogenetic mechanisms of the described diseases. The importance is stressed of prevention, which must be based on planned regular breaks in the hanging position, checking on the fit and comfort level of the harness before it is first used, as well as medical surveillance of the subjects who spend prolonged periods in a harness for work or recreation.

Modeling annual extreme temperature using generalized extreme value distribution: A case study in Malaysia

NASA Astrophysics Data System (ADS)

Hasan, Husna; Salam, Norfatin; Kassim, Suraiya

2013-04-01

Extreme temperature of several stations in Malaysia is modeled by fitting the annual maximum to the Generalized Extreme Value (GEV) distribution. The Augmented Dickey Fuller (ADF) and Phillips Perron (PP) tests are used to detect stochastic trends among the stations. The Mann-Kendall (MK) test suggests a non-stationary model. Three models are considered for stations with trend and the Likelihood Ratio test is used to determine the best-fitting model. The results show that Subang and Bayan Lepas stations favour a model which is linear for the location parameters while Kota Kinabalu and Sibu stations are suitable with a model in the logarithm of the scale parameters. The return level is the level of events (maximum temperature) which is expected to be exceeded once, on average, in a given number of years, is obtained.

Copper diffusion and mechanical toughness at Cu-silica interfaces glued with polyelectrolyte nanolayers

NASA Astrophysics Data System (ADS)

Gandhi, D. D.; Singh, A. P.; Lane, M.; Eizenberg, M.; Ramanath, G.

2007-04-01

We demonstrate the use of polyallylamine hydrochloride (PAH)-polystyrene sulfonate (PSS) nanolayers to block Cu transport into silica. Cu/PSS-PAH/SiO2 structures show fourfold enhancement in device failure times during bias thermal annealing at 200 °C at an applied electric field of 2 MV/cm, when compared with structures with pristine Cu-SiO2 interfaces. Although the bonding at both Cu-PSS and PAH-SiO2 interfaces are strong, the interfacial toughness measured by the four-point bend tests is ˜2 Jm-2. Spectroscopic analysis of fracture surfaces reveals that weak electrostatic bonding at the PSS-PAH interface is responsible for the low toughness. Similar behavior is observed for Cu-SiO2 interfaces modified with other polyelectrolyte bilayers that inhibit Cu diffusion. Thus, while strong bonding at Cu-barrier and barrier-dielectric interfaces may be sufficient for blocking copper transport across polyelectrolyte bilayers, strong interlayer molecular bonding is a necessary condition for interface toughening. These findings are of importance for harnessing MNLs for use in future device wiring applications.

78 FR 14442 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... certain serial number (S/N) N2 sensor harnesses. This AD requires replacement of the same S/N harnesses, and requires replacement of additional S/N N2 sensor harnesses. This AD was prompted by corrosion detected in affected N2 sensor harnesses. We are issuing this AD to prevent inadvertent activation of the...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... fasten and unfasten that person's safety belt and, if installed, shoulder harness. (2) No pilot may cause...

Registration of two double rust resistant germplasms, HA-R12 and HA-R13 for confection sunflower

USDA-ARS?s Scientific Manuscript database

The confection sunflower (Helianthus annuus L.) germplasms HA-R12 (Reg. No. ______, PI 673104) and HA-R13 (Reg. No. ______, PI 673105) were developed by the USDA-ARS, Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station, and released in Jul...

Registration of two confection sunflower germplasm Lines, HA-R10 and HA-R11, Resistant to sunflower rust

USDA-ARS?s Scientific Manuscript database

Two confection sunflower (Helianthus annuus L.) germplasm lines, HA-R10 (Reg. No.xxx, PI670043) and HA-R11 (Reg. No.xxx, PI670044) were developed by the USDA-ARS Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station and released December, 20...

JWST ISIM Harness Thermal Evaluation

NASA Technical Reports Server (NTRS)

Kobel, Mark; Glazer, Stuart; Tuttle, Jim; Martins, Mario; Ruppel, Sean

2008-01-01

The James Webb Space Telescope (JWST) will be a large infrared telescope with a 6.5-meter primary mirror. Launch is planned for 2013. JWST wl1 be the premier observatory of the next decade serving thousands of astronomers worldwide. The Integrated Science Instrument Module (ISIM) is the unit that will house thc four main JWST instruments. The ISIM enclosure passively cooled to 37 Kelvin and has a tightly managed thermal budget. A significant portion of the ISIM heat load is due to parasitic heat gains from the instrument harnesses. These harnesses provide a thermal path from the Instrument Electronics Control (IEC) to the ISIM. Because of the impact of this load to the ISIM thermal design, understanding the harness parasitic heat gains is critical. To this effect, a thermal test program has been conducted in order to characterize these parasitic loads and verify harness thermal models. Recent parasitic heat loads tests resulted in the addition of a dedicated multiple stage harness radiator. In order for the radiator to efficiently reject heat from the harness, effective thermal contact conductance values for multiple harnesses had to be determined. This presentation will describe the details and the results of this test program.

Positioning bars for large wire harnesses

NASA Technical Reports Server (NTRS)

Glessner, J. R.

1978-01-01

By tying positioning bars to harness, its configuration can be preserved during transport, thus facilitating installation. Harness can also be showed temporarily by placing hanging hooks on end of bar.

Low-frequency Radio Observatory on the Lunar Surface (LROLS)

NASA Astrophysics Data System (ADS)

MacDowall, Robert; Network for Exploration and Space Science (NESS)

2018-06-01

A radio observatory on the lunar surface will provide the capability to image solar radio bursts and other sources. Radio burst imaging will improve understanding of radio burst mechanisms, particle acceleration, and space weather. Low-frequency observations (less than ~20 MHz) must be made from space, because lower frequencies are blocked by Earth’s ionosphere. Solar radio observations do not mandate an observatory on the farside of the Moon, although such a location would permit study of less intense solar bursts because the Moon occults the terrestrial radio frequency interference. The components of the lunar radio observatory array are: the antenna system consisting of 10 – 100 antennas distributed over a square kilometer or more; the system to transfer the radio signals from the antennas to the central processing unit; electronics to digitize the signals and possibly to calculate correlations; storage for the data until it is down-linked to Earth. Such transmission requires amplification and a high-gain antenna system or possibly laser comm. For observatories on the lunar farside a satellite or other intermediate transfer system is required to direct the signal to Earth. On the ground, the aperture synthesis analysis is completed to display the radio image as a function of time. Other requirements for lunar surface systems include the power supply, utilizing solar arrays with batteries to maintain the system at adequate thermal levels during the lunar night. An alternative would be a radioisotope thermoelectric generator requiring less mass. The individual antennas might be designed with their own solar arrays and electronics to transmit data to the central processing unit, but surviving lunar night would be a challenge. Harnesses for power and data transfer from the central processing unit to the antennas are an alternative, but a harness-based system complicates deployment. The concept of placing the antennas and harnesses on rolls of polyimide and rolling them out may be a solution for solar radio observations, but it probably does not provide a sufficiently-uniform beam for other science targets.

Genomic and Network Patterns of Schizophrenia Genetic Variation in Human Evolutionary Accelerated Regions

PubMed Central

Xu, Ke; Schadt, Eric E.; Pollard, Katherine S.; Roussos, Panos; Dudley, Joel T.

2015-01-01

The population persistence of schizophrenia despite associated reductions in fitness and fecundity suggests that the genetic basis of schizophrenia has a complex evolutionary history. A recent meta-analysis of schizophrenia genome-wide association studies offers novel opportunities for assessment of the evolutionary trajectories of schizophrenia-associated loci. In this study, we hypothesize that components of the genetic architecture of schizophrenia are attributable to human lineage-specific evolution. Our results suggest that schizophrenia-associated loci enrich in genes near previously identified human accelerated regions (HARs). Specifically, we find that genes near HARs conserved in nonhuman primates (pHARs) are enriched for schizophrenia-associated loci, and that pHAR-associated schizophrenia genes are under stronger selective pressure than other schizophrenia genes and other pHAR-associated genes. We further evaluate pHAR-associated schizophrenia genes in regulatory network contexts to investigate associated molecular functions and mechanisms. We find that pHAR-associated schizophrenia genes significantly enrich in a GABA-related coexpression module that was previously found to be differentially regulated in schizophrenia affected individuals versus healthy controls. In another two independent networks constructed from gene expression profiles from prefrontal cortex samples, we find that pHAR-associated schizophrenia genes are located in more central positions and their average path lengths to the other nodes are significantly shorter than those of other schizophrenia genes. Together, our results suggest that HARs are associated with potentially important functional roles in the genetic architecture of schizophrenia. PMID:25681384

Are we ignoring neutral and negative human-animal relationships in zoos?

PubMed

Hosey, Geoff; Melfi, Vicky

2015-01-01

Human-animal interactions (HAI), which may lead to human-animal relationships (HAR), may be positive, neutral, or negative in nature. Zoo studies show that visitors may be stressful, may have no effect, or may be enriching. There is also evidence that good HARs set up between animals and their keepers can have positive effects on animal welfare. However, we need to know more about negative HARs, and as a first step we attempt to do this here by considering cases where animals attack people in the zoo. Due to the sensitivity and rarity of these events data appear sparse and unsystematically collected. Here, information available in the public domain about the circumstances of these attacks has been collated to test hypotheses about negative HAIs derived from a model of zoo HARs. The limited data presented here broadly support the zoo HAR model, and suggest that attacks usually happen in unusual circumstances, where there may be a failure by the animal to recognise the HAR, or where the relationship, if there is one, does not hold; and give some support to the prediction that exposure to many keepers may impair the development of a positive HAR. This study may provide useful information for the zoo community to proactively collect systematic standardised records, which will enable a fuller understanding of zoo HARs, upon which appropriate measures might be adopted to build better zoo HARs, which are likely to positively impact zoo animal welfare, and reduce these rare incidences further. © 2014 Wiley Periodicals, Inc.

Virginia Department of Transportation HAR Operational Guidelines

DOT National Transportation Integrated Search

1995-08-01

These guidelines have been developed to help Virginia Department of Transportation (VDOT) personnel effectively operate highway advisory radio (HAR) systems. Operators should continually bear in mind that it is of paramount importance that HAR messag...

Proterozoic low-Ti iron-oxide deposits in New York and New Jersey: relation to Fe-oxide (Cu-U-Au-rare earth element) deposits and tectonic implications

USGS Publications Warehouse

Foose, M.P.; McLelland, J.M.

1995-01-01

Low-Ti iron-oxide deposits in exposed Grenville-age rocks of New York and New Jersey belong to a distinct class of iron-oxide (Cu-U-Au-rare earth element [REE]) deposits that includes similar iron deposits in southeastern Missouri and the Kiruna district of Sweden, the giant Olympic Dam U-Cu-Au-Ag deposit (Australia), and the Bayan Obo REE-Nb deposit (China). Most of the New York-New Jersey deposits exhibit features consistent with a hydrothermal origin and define a regionally significant metallogenic event that provides important clues to the evolution of this part of the Grenville orogen. In the Adirondacks, the tectonic setting of these deposits is consistent with postorogenic uplift and extensive crustal melting at 1070-1050 Ma that was accompanied by late tectonic to posttectonic deposition of iron. -Authors

Region IV Transit Workshop: Harnessing the Private Sector

DOT National Transportation Integrated Search

1988-09-01

This Report constitutes the Proceedings of the Region IV Transit Workshop: : Harnessing the Private Sector. Included in this document is a general report of : the activities of the Workshop. : The purpose ot the Region IV Transit Workshop: Harnessing...

[Binding interaction of harpagoside and bovine serum albumin: spectroscopic methodologies and molecular docking].

PubMed

Cao, Tuan-Wu; Huang, Wen-Bing; Shi, Jian-Wei; He, Wei

2018-03-01

Scrophularia ningpoensis has exhibited a variety of biological activities and been used as a pharmaceutical product for the treatment of inflammatory ailment, rheumatoid arthritis, osteoarthritis and so on. Harpagoside (HAR) is considerer as a main bioactive compound in this plant. Serum albumin has important physiological roles in transportation, distribution and metabolism of many endogenous and exogenous substances in body. It is of great significance to study the interaction mechanism between HAR and bovine serum albumin (BSA). The mechanism of interaction between HAR and BSA was investigated using 2D and 3D fluorescence, synchronous florescence, ultraviolet spectroscopy and molecular docking. According to the analysis of fluorescence spectra, HAR could strongly quench the fluorescence of BSA, and the static quenching process indicated that the decrease in the quenching constant was observed with the increase in temperature. The magnitude of binding constants (KA) was more than 1×10⁵ L·mol⁻¹, and the number of binding sites(n) was approximate to 1. The thermodynamic parameters were calculated through analysis of fluorescence data with Stern-Volmer and Van't Hoff equation. The calculated enthalpy change (ΔH) and entropy change (ΔS) implied that the main interaction forces of HAR with BSA were the bonding interaction between van der Waals forces and hydrogen. The negative values of energy (ΔG) demonstrated that the binding of HAR with BSA was a spontaneous and exothermic process. The binding distance(r) between HAR and BSA was calculated to be about 2.80 nm based on the theory of Frster's non-radiation energy transfer, which indicated that energy is likely to be transfer from BSA to HAR. Both synchronous and 3D florescence spectroscopy clearly revealed that the microenvironment and conformation of BSA changed during the binding interaction between HAR and BSA. The molecular docking analysis revealed HAR is more inclined to BSA and human serum albumin (HSA) in subdomain ⅡA (Sudlow's site I). This study will provide valuable information for understanding the action mechanism of HAR. Copyright© by the Chinese Pharmaceutical Association.

MSFC inspections of installed polyimide wire

NASA Technical Reports Server (NTRS)

Landers, Joe C.

1994-01-01

An alert was issued because of the arc-tracking possibilities of installed polyimide wire harnesses. MSFC undertook a program to try to enhance the safety and reliability of these harnesses. Photographs are presented showing the need for inspections of installed wiring harnesses.

Hybrid Toffoli gate on photons and quantum spins

PubMed Central

Luo, Ming-Xing; Ma, Song-Ya; Chen, Xiu-Bo; Wang, Xiaojun

2015-01-01

Quantum computation offers potential advantages in solving a number of interesting and difficult problems. Several controlled logic gates, the elemental building blocks of quantum computer, have been realized with various physical systems. A general technique was recently proposed that significantly reduces the realization complexity of multiple-control logic gates by harnessing multi-level information carriers. We present implementations of a key quantum circuit: the three-qubit Toffoli gate. By exploring the optical selection rules of one-sided optical microcavities, a Toffoli gate may be realized on all combinations of photon and quantum spins in the QD-cavity. The three general controlled-NOT gates are involved using an auxiliary photon with two degrees of freedom. Our results show that photons and quantum spins may be used alternatively in quantum information processing. PMID:26568078

Hybrid Toffoli gate on photons and quantum spins.

PubMed

Luo, Ming-Xing; Ma, Song-Ya; Chen, Xiu-Bo; Wang, Xiaojun

2015-11-16

Quantum computation offers potential advantages in solving a number of interesting and difficult problems. Several controlled logic gates, the elemental building blocks of quantum computer, have been realized with various physical systems. A general technique was recently proposed that significantly reduces the realization complexity of multiple-control logic gates by harnessing multi-level information carriers. We present implementations of a key quantum circuit: the three-qubit Toffoli gate. By exploring the optical selection rules of one-sided optical microcavities, a Toffoli gate may be realized on all combinations of photon and quantum spins in the QD-cavity. The three general controlled-NOT gates are involved using an auxiliary photon with two degrees of freedom. Our results show that photons and quantum spins may be used alternatively in quantum information processing.

Impact of Harness Attachment Point on Kinetics and Kinematics During Sled Towing.

PubMed

Bentley, Ian; Atkins, Steve J; Edmundson, Christopher J; Metcalfe, John; Sinclair, Jonathan K

2016-03-01

Resisted sprint training is performed in a horizontal direction and involves similar muscles, velocities, and ranges of motion (ROM) to those of normal sprinting. Generally, sleds are attached to the athletes through a lead (3 m) and harness; the most common attachment points are the shoulder or waist. At present, it is not known how the different harness point's impact on the kinematics and kinetics associated with sled towing (ST). The aim of the current investigation was to examine the kinetics and kinematics of shoulder and waist harness attachment points in relation to the acceleration phase of ST. Fourteen trained men completed normal and ST trials, loaded at 10% reduction of sprint velocity. Sagittal plane kinematics from the trunk, hip, knee, and ankle were measured, together with stance phase kinetics (third footstrike). Kinetic and kinematic parameters were compared between harness attachments using one-way repeated-measures analysis of variance. The results indicated that various kinetic differences were present between the normal and ST conditions. Significantly greater net horizontal mean force, net horizontal impulses, propulsive mean force, and propulsive impulses were measured (p < 0.05). Interestingly, the waist harness also led to greater net horizontal impulse when compared with the shoulder attachment (p < 0.001). In kinematic terms, ST conditions significantly increased peak flexion in hip, knee, and ankle joints compared with the normal trials (p < 0.05). Results highlighted that the shoulder harness had a greater impact on trunk and knee joint kinematics when compared with the waist harness (p < 0.05). In summary, waist harnesses seem to be the most suitable attachment point for the acceleration phase of sprinting. Sled towing with these attachments resulted in fewer kinematic alterations and greater net horizontal impulse when compared with the shoulder harness. Future research is necessary in order to explore the long-term adaptations of these acute changes.

Effects of firefighters' self-contained breathing apparatus' weight and its harness design on the physiological and subjective responses.

PubMed

Bakri, Ilham; Lee, Joo-Young; Nakao, Kouhei; Wakabayashi, Hitoshi; Tochihara, Yutaka

2012-01-01

To examine the effects of firefighters' self-contained breathing apparatus' (SCBA) weight and its harness design on the physiological and subjective responses, eight male students performed treadmill exercise under four conditions: the 8 kg firefighter protective clothing (PC) (Control), the PC + an 11 kg SCBA with an old harness (Test A), the PC + a 6.4 kg SCBA with an old harness (Test B) and the PC + a 6.4 kg SCBA with a new harness (Test C), at ambient temperatures (T(a)) of 22°C and 32°C. Besides highlighting the fact that a heavy SCBA had a significant effect on the oxygen consumption and metabolic rate, this experiment also found that in a T(a) of 32°C, in particular, the combined effect of 4.7 kg lighter SCBA and new harness design could reduce metabolic rate and improved subjective muscle fatigue and thermal discomfort. An effort to alleviate the physiological and subjective burden of firefighters by reducing the weight of SCBA and by using the new harness design has provided satisfactory results in reduced oxygen consumption and in improved subjective responses in a hot air environment.

The benefits of the use of shoulder harness in general aviation aircraft.

DOT National Transportation Integrated Search

1972-02-01

The installation and use of shoulder harnesses is a practical and relatively inexpensive solution to the problem of maintaining separation between man and machine during an aircraft crash sequence. The addition of shoulder harness to the tiedown chai...

42 CFR 84.196 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Chemical Cartridge Respirators § 84.196 Harnesses; installation and construction; minimum...

Spring control of wire harness loops

NASA Technical Reports Server (NTRS)

Curcio, P. J.

1979-01-01

Negator spring control guides wire harness between movable and fixed structure. It prevents electrical wire harness loop from jamming or being severed as wire moves in response to changes in position of aircraft rudder. Spring-loaded coiled cable controls wire loop regardless of rudder movement.

SSME Electrical Harness and Cable Development and Evolution

NASA Technical Reports Server (NTRS)

Abrams, Russ; Heflin, Johnny; Burns, Bob; Camper, Scott J.; Hill, Arthur J.

2010-01-01

The Space Shuttle Main Engine (SSME) electrical harness and cable system consists of the various interconnecting devices necessary for operation of complex rocket engine functions. Thirty seven harnesses incorporate unique connectors, backshell adapters, conductors, insulation, shielding, and physical barriers for a long maintenance-free life while providing the means to satisfy performance requirements and to mitigate adverse environmental influences. The objective of this paper is to provide a description of the SSME electrical harness and cable designs as well as the development history and lessons learned.

Damping Models for Shear-Deformable Beam with Applications to Spacecraft Wiring Harness

DTIC Science & Technology

2014-10-28

AFRL-RV-PS- TR-2014-0189 AFRL-RV-PS- TR-2014-0189 DAMPING MODELS FOR SHEAR-DEFORMABLE BEAM WITH APPLICATIONS TO SPACECRAFT WIRING HARNESS ...Feb 2012 4. TITLE AND SUBTITLE Damping Models for Shear-Deformable Beam with Applications to Spacecraft Wiring Harness 5a. CONTRACT NUMBER FA9453-12...behavior of wiring harnesses . The emphasis in this project will be on the extension of the shear-beam damping model to the Timoshenko beam, a beam model

Heritability and factors associated with number of harness race starts in the Spanish Trotter horse population.

PubMed

Solé, M; Valera, M; Gómez, M D; Sölkner, J; Molina, A; Mészáros, G

2017-05-01

Longevity/durability is a relevant trait in racehorses. Genetic analysis and knowledge of factors that influence number of harness race starts would be advantageous for both horse welfare and the equine industry. To perform a genetic analysis on harness racing using number of races as a measure of longevity/durability and to identify factors associated with career length in Spanish Trotter Horses (STH). Longitudinal study. Performance data (n = 331,970) on the STH population for harness racing at national level between 1990 and 2014 were used. A grouped data model was fitted to assess factors influencing the risk of ending harness racing career and to estimate the heritability and breeding values for total number of harness races starts as an indicator of horses' longevity and durability. The model included sex, age at first race and first start earnings as time-independent effects, and the calendar year, driver, trainer, racetrack category and season of competition as time-dependent effects. Across the whole dataset, the average number of harness races horses achieved in Spain was 54.7 races, and this was associated with the horses' sex, age at first race and first start earnings, calendar year, driver, racetrack category, and season. The heritability estimated (0.17 ± 0.01) for number of harness race starts indicates that a beneficial response to direct genetic selection can be expected. Data on horses' health status were not available. Horses' total number of harness race starts is a promising tool for genetic analysis and the evaluation of racing longevity and durability. The estimated heritability provides evidence to support the application of genetic selection of total career number of races to improve longevity/durability of STH. © 2016 EVJ Ltd.

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity.

PubMed

Frisoni, Giovanni B; Jack, Clifford R; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G; deToledo-Morrell, Leyla; Geerlings, Mirjam I; Kaye, Jeffrey; Killiany, Ronald J; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; Pasqualetti, Patrizio; Duchesne, Simon; Duvernoy, Henri; Boccardi, Marina

2015-02-01

An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

PubMed Central

Frisoni, Giovanni B.; Jack, Clifford R.; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S.; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J.; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G.; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G.; deToledo-Morrell, Leyla; Geerlings, Mirjam I.; Kaye, Jeffrey; Killiany, Ronald J.; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C.; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C.; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; Pasqualetti, Patrizio; Duchesne, Simon; Duvernoy, Henri; Boccardi, Marina

2015-01-01

Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). Conclusions The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. PMID:25267715

Methylation controls the low temperature induction of flowering in Arabidopsis.

PubMed

Dennis, E S; Bilodeau, P; Burn, J; Finnegan, E J; Genger, R; Helliwell, C; Kang, B J; Sheldon, C C; Peacock, W J

1998-01-01

Control of the transition to flowering is critical for reproductive success of a plant. Studies in Arabidopsis have led us to suggest how this species has harnessed the environmental cue of a period of low temperature to ensure flowering occurs at an appropriate time. We propose that Arabidopsis has both vernalization-independent and vernalization-dependent pathways for the initiation of inflorescence development in the shoot apex. The vernalization-independent pathway may be concerned with the supply of carbohydrate to the shoot apex. In late flowering ecotypes which respond to vernalization the vernalization-independent pathway is blocked by the action of two dominant repressors of flowering, FRI and FLC, which interact to produce very late flowering plants which respond strongly to vernalization. We have isolated a gene which may correspond to FLC. We suggest the vernalization-dependent pathway, which may be concerned with apical GA biosynthesis, is blocked by methylation of a gene critical for flowering. This gene may correspond to that encoding kaurenoic acid hydroxylase (KAH), an enzyme catalysing a step in the GA biosynthetic pathway. Under this scheme vernalization causes unblocking of this pathway by demethylation possibly of the KAH gene and consequent biosynthesis of active GAs in the apex.

Conversion of amides to esters by the nickel-catalysed activation of amide C-N bonds.

PubMed

Hie, Liana; Fine Nathel, Noah F; Shah, Tejas K; Baker, Emma L; Hong, Xin; Yang, Yun-Fang; Liu, Peng; Houk, K N; Garg, Neil K

2015-08-06

Amides are common functional groups that have been studied for more than a century. They are the key building blocks of proteins and are present in a broad range of other natural and synthetic compounds. Amides are known to be poor electrophiles, which is typically attributed to the resonance stability of the amide bond. Although amides can readily be cleaved by enzymes such as proteases, it is difficult to selectively break the carbon-nitrogen bond of an amide using synthetic chemistry. Here we demonstrate that amide carbon-nitrogen bonds can be activated and cleaved using nickel catalysts. We use this methodology to convert amides to esters, which is a challenging and underdeveloped transformation. The reaction methodology proceeds under exceptionally mild reaction conditions, and avoids the use of a large excess of an alcohol nucleophile. Density functional theory calculations provide insight into the thermodynamics and catalytic cycle of the amide-to-ester transformation. Our results provide a way to harness amide functional groups as synthetic building blocks and are expected to lead to the further use of amides in the construction of carbon-heteroatom or carbon-carbon bonds using non-precious-metal catalysis.

The angle of shoulder slope in normal males as a factor in shoulder-harness design.

DOT National Transportation Integrated Search

1965-03-01

In order to establish criteria for more comfortable shoulder-harness design, this study was conducted to determine the angle of slope of the top of the shoulders where poorly fitting shoulder harness may produce discomfort and, occasionally, function...

42 CFR 84.133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air Respirators § 84.133 Harnesses; installation and construction; minimum requirements...

Introduction of hand-assisted retroperitoneoscopic living donor nephrectomy at Karolinska University Hospital Huddinge.

PubMed

Gjertsen, H; Sandberg, A-K A; Wadström, J; Tydén, G; Ericzon, B-G

2006-10-01

Living donor kidney transplantation accounts for about 50% of the total number of renal transplantations at our center. From 1999 through 2005, 75 out of 220 living donor nephrectomies were performed with a laparoscopic technique (LLDN). In June 2005, we introduced the technique of hand-assisted retroperitoneoscopic nephrectomy (HARS) for living donors. Since the introduction until the end of 2005, 11 out of 18 living donor nephrectomies (LDN) were performed with HARS. Reduced operation time was observed for the HARS group (mean, 166 minutes) compared with the LLDN (mean, 244 minutes). Two grafts showed delayed function, one in the LLND group and one in the HARS group. No major perioperative or postoperative complications were observed in the HARS group, whereas one patient who underwent LLDN developed severe pancreatitis. So far in our hands HARS is a fast and safe procedure with results comparable with open LDN. Compared to LLDN, we experienced reduced operation time together with the advantage of retroperitoneal access.

An examination of shoulder kinematics and kinetics when using a commercial trunk harness while sheep shearing.

PubMed

Gregory, Diane E; Milosavljevic, Stephan; Pal, Poonam; Callaghan, Jack P

2008-01-01

Sheep shearing is a very physically demanding occupation, especially on the low back, such that many commercial harnesses have been developed to help reduce the load on the back. Such harnesses have been shown to significantly reduce peak and cumulative low back loads; however, the effect that these harnesses have on the shoulders, which are also highly involved during sheep shearing, has not been previously examined. The purpose of this study was to examine the shoulder postures and cumulative shoulder moments of 12 New Zealand sheep shearers. The use of the trunk harness reduced the percentage of time spent in shoulder flexion greater than 90 degrees and the time spent in shoulder abduction greater than 45 degrees as well as reduced the cumulative net joint flexor, abductor, and adductor shoulder moments by a minimum of 21%, 14%, and 42%, respectively. Therefore, the use of a commercial trunk harness to reduce low back injury may also help to reduce the risk of shoulder injury while sheep shearing.

Loss of Consciousness During Single Sling Helicopter Hoist Rescue Resulting in a Fatal Fall.

PubMed

Biles, Jessie; Garner, Alan A

2016-09-01

Although harness suspension trauma has been documented since the 1960s, especially in the mountaineering setting, there is little robust medical research into the area. Helicopter hoist rescue shares similar risks and is reserved for those cases that cannot be accessed safely by other routes, where extrication may be hazardous or will take an unreasonable amount of time. The single sling or chest harness used for hoist rescue is a single harness around the upper torso and is easier and quicker to apply than a stretcher. However, the risks of a chest harness need to be balanced against the patient's condition, the environment, aircraft performance, and the urgency of the rescue. We report an adult male falling 80 ft to his death while being hoisted into a rescue helicopter for a likely fractured ankle. A single rescue sling harness technique was used, but the patient became unconscious, slipped out of the harness, and fell. He had significant comorbidities, including cardiomyopathy, obstructive sleep apnea, morbid obesity, and diabetes. A decrease in cardiac output secondary to thoracic compression was the presumed cause for his loss of consciousness and the potential physiological mechanisms and modifying factors are discussed. Further research into harness suspension trauma is required. Stretcher, double point harnesses, or rescue baskets are likely safer methods of hoisting, especially in a medically compromised patient. Biles J, Garner AA. Loss of consciousness during single sling helicopter hoist rescue resulting in a fatal fall. Aerosp Med Hum Perform. 2016; 87(9):821-824.

Lumbar spine disc heights and curvature: upright posture vs. supine compression harness

NASA Technical Reports Server (NTRS)

Lee, Shi-Uk; Hargens, Alan R.; Fredericson, Michael; Lang, Philipp K.

2003-01-01

INTRODUCTION: Spinal lengthening in microgravity is thought to cause back pain in astronauts. A spinal compression harness can compress the spine to eliminate lengthening but the loading condition with harness is different than physiologic conditions. Our purpose was to compare the effect of spine compression with a harness in supine position on disk height and spinal curvature in the lumbar spine to that of upright position as measured using a vertically open magnetic resonance imaging system. METHODS: Fifteen healthy subjects volunteered. On day 1, each subject lay supine for an hour and a baseline scan of the lumbar spine was performed. After applying a load of fifty percent of body weight with the harness for thirty minutes, the lumbar spine was scanned again. On day 2, after a baseline scan, a follow up scan was performed after kneeling for thirty minutes within the gap between two vertically oriented magnetic coils. Anterior and posterior disk heights, posterior disk bulging, and spinal curvature were measured from the baseline and follow up scans. RESULTS: Anterior disk heights increased and posterior disk heights decreased compared with baseline scans both after spinal compression with harness and upright posture. The spinal curvature increased by both loading conditions of the spine. DISCUSSION: The spinal compression with specially designed harness has the same effect as the physiologic loading of the spine in the kneeling upright position. The harness shows some promise as a tool to increase the diagnostic capabilities of a conventional MR system.

Characterizing the Three-Dimensional Structure of Block Copolymers via Sequential Infiltration Synthesis and Scanning Transmission Electron Tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Segal-Peretz, Tamar; Winterstein, Jonathan; Doxastakis, Manolis

Understanding and controlling the three-dimensional structure of block copolymer (BCP) thin films is critical for utilizing these materials for sub-20 nm nanopatterning in semiconductor devices, as well as in membranes and solar cell applications. Combining an atomic layer deposition (ALD) based technique for enhancing the contrast of BCPs in transmission electron microscopy (TEM) together with scanning TEM (STEM) tomography reveals and characterizes the three-dimensional structures of poly(styrene-block-methyl methacrylate) (PS-b-PMMA) thin films with great clarity. Sequential infiltration synthesis (SIS), a block-selective technique for growing inorganic materials in BCPs films in ALD, and an emerging tool for enhancing the etch contrast ofmore » BCPs, was harnessed to significantly enhance the high-angle scattering from the polar domains of BCP films in the TEM. The power of combining SIS and STEM tomography for three dimensional (3D) characterization of BCPs films was demonstrated with the following cases: self-assembled cylindrical, lamellar, and spherical PS-PMMA thin films. In all cases, STEM tomography has revealed 3D structures that were hidden underneath the surface, including: 1) the 3D structure of defects in cylindrical and lamellar phases, 2) non-perpendicular 3D surface of grain boundaries in the cylindrical phase, and 3) the 3D arrangement of spheres in body centered cubic (BCC) and hexagonal closed pack (HCP) morphologies in the spherical phase. The 3D data of the spherical morphologies was compared to coarse-grained simulations and assisted in validating the simulations’ parameters. STEM tomography of SIS-treated BCP films enables the characterization of the exact structure used for pattern transfer, and can lead to better understating of the physics which is utilized in BCP lithography.« less

Timing of the final closure of the Paleo-Asian Ocean in the Alxa Terrane: Constraints from geochronology and geochemistry of Late Carboniferous to Permian gabbros and diorites

NASA Astrophysics Data System (ADS)

Liu, Qian; Zhao, Guochun

2017-04-01

The Alxa Terrane is a crucial place situated between the North China Craton to the east and the Tarim Craton to the west. The Late Paleozoic magmatic record in the Alxa Terrane places important constraints on the timing of the final closure of the middle segment of the Paleo-Asian Ocean (PAO). In this study, new LA-ICPMS zircon U-Pb dating results reveal ca. 300-268 Ma gabbros and diorites in the Bayan Nuru area in the eastern part of the Alxa Terrane. The 300 Ma gabbros show plagioclase accumulations with anorthite compositions (An92-95), arc-like geochemical affinities with relative enrichment in large ionic lithophile elements and depletion in high field strength elements (e.g., Ti, Nb and Ta), as well as negative Hf(t) (-6.01 to -1.75) and Nd(t) (-9.5 to -7.1) values and high initial 87Sr/86Sr ratios (0.707157-0.707220). These features indicate a magma source of an enriched lithospheric mantle metasomatized by high fluid activities. In comparison, the 280-268 Ma gabbros and diorites also have arc-like geochemical affinities but show increasingly evolved isotope compositions, implying more sediment inputs. Compiled zircon ɛHf(t) and whole-rock ɛNd(t) values of the magmatic rocks in the Alxa Terrane decrease from the Late Carboniferous to the Early Permian, and increase from the Middle Permian to the Triassic. The considerably large spread in ɛHf(t) and ɛNd(t) values at ca. 280-265 Ma likely reflects a tectonic switch from a subduction setting to a post-collisional setting, corresponding to the timing of the final closure of the PAO in the Alxa Terrane. Thus, the PAO progressively closed from west to east along the northern margin of the Tarim Craton, the Alxa Terrane, and then the northern margin of the North China Craton during Late Carboniferous to Middle Triassic time. This work was financially supported by a NSFC Project (41190075) entitled "Final Closure of the Paleo-Asian ocean and Reconstruction of East Asian Blocks in Pangea", the fifth research project in the NSFC Major Program (41190070) "Reconstruction of East Asian Blocks in Pangea", a Hong Kong RGC GRF (HKU7063/13P and 17301915), NSFC General Projects (41230207 and 41390441) and a HKU Seed Funding Programme for Basic Research (201311159126).

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

75 FR 51701 - Airworthiness Directives; Learjet Inc. Model 45 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... configuration of the engine and alternator wire harnesses, and the starter/generator wire bundles. For certain... necessary. For certain airplanes, inspecting for clearance between the wire harnesses and the hydraulic and... wire harnesses and the starter/generator wire bundles. (2) Do a detailed inspection for chafing damage...

Symmetry-adapted perturbation theory interaction energy decomposition for some noble gas complexes

NASA Astrophysics Data System (ADS)

Cukras, Janusz; Sadlej, Joanna

2008-06-01

This Letter contains a study of the interaction energy in HArF⋯N 2 and HArF⋯P 2 complexes. Symmetry-adapted perturbation theory (SAPT) has been applied to analyze the electrostatic, induction, dispersion and exchange contributions to the total interaction energy. The interaction energy has also been obtained by supermolecular method at the MP2, MP4, CCSD, CCSD(T) levels. The interaction energy for the studied complexes results from a partial cancelation of large attractive electrostatic, induction, dispersion terms by a strong repulsive exchange contribution. The induction and dispersion effects proved to be crucial in establishing the preference for the colinear HArF⋯N 2 and HArF⋯P 2 structures and shift direction of νHAr stretching vibrations.

Structural changes and out-of-sample prediction of realized range-based variance in the stock market

NASA Astrophysics Data System (ADS)

Gong, Xu; Lin, Boqiang

2018-03-01

This paper aims to examine the effects of structural changes on forecasting the realized range-based variance in the stock market. Considering structural changes in variance in the stock market, we develop the HAR-RRV-SC model on the basis of the HAR-RRV model. Subsequently, the HAR-RRV and HAR-RRV-SC models are used to forecast the realized range-based variance of S&P 500 Index. We find that there are many structural changes in variance in the U.S. stock market, and the period after the financial crisis contains more structural change points than the period before the financial crisis. The out-of-sample results show that the HAR-RRV-SC model significantly outperforms the HAR-BV model when they are employed to forecast the 1-day, 1-week, and 1-month realized range-based variances, which means that structural changes can improve out-of-sample prediction of realized range-based variance. The out-of-sample results remain robust across the alternative rolling fixed-window, the alternative threshold value in ICSS algorithm, and the alternative benchmark models. More importantly, we believe that considering structural changes can help improve the out-of-sample performances of most of other existing HAR-RRV-type models in addition to the models used in this paper.

Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry.

PubMed

Wolf, Dominik; Bocchetta, Martina; Preboske, Gregory M; Boccardi, Marina; Grothe, Michel J

2017-08-01

A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple atlas-based morphometry approach for automated calculation of HarP-compliant hippocampal volumes within SPM software. Individual tracings showed very high agreement among the four expert tracers (pairwise Jaccard indices 0.82-0.87). Automatically calculated hippocampal volumes were highly correlated (r L/R  = 0.89/0.91) with gold standard volumes in the HarP benchmark data set (N = 135 MRIs), with a mean volume difference of 9% (standard deviation 7%). The consensual HarP hippocampus labels in the MNI152 template can serve as a reference standard for automated image analyses involving MNI standard space normalization. Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Design and Analyses of High Aspect Ratio Nozzles for Distributed Propulsion Acoustic Measurements

NASA Technical Reports Server (NTRS)

Dippold, Vance F., III

2016-01-01

A series of three convergent, round-to-rectangular high aspect ratio (HAR) nozzles were designed for acoustic testing at the NASA Glenn Research Center Nozzle Acoustic Test Rig (NATR). The HAR nozzles had exit area aspect ratios of 8:1, 12:1, and 16:1. The nozzles were designed to mimic a distributed propulsion system array with a slot nozzle. The nozzle designs were screened using Reynolds-Averaged Navier-Stokes (RANS) simulations. In addition to meeting the geometric constraints required for testing in the NATR, the HAR nozzles were designed to be free of flow features that would produce unwanted noise (e.g., flow separations) and to have uniform flow at the nozzle exit. Multiple methods were used to generate HAR nozzle designs. The final HAR nozzle designs were generated in segments using a computer code that parameterized each segment. RANS screening simulations showed that intermediate nozzle designs suffered flow separation, a normal shockwave at the nozzle exit (caused by an aerodynamic throat produced by boundary layer growth), and non-uniform flow at the nozzle exit. The RANS simulations showed that the final HAR nozzle designs were free of flow separations, but were not entirely successful at producing a fully uniform flow at the nozzle exit. The final designs suffered a pair of counter-rotating vortices along the outboard walls of the nozzle. The 16:1 aspect ratio HAR nozzle had the least uniform flow at the exit plane; the 8:1 aspect ratio HAR nozzles had a fairly uniform flow at the nozzle exit plane.

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

Harnessing the Power of Information Technology: Open Business Models in Higher Education

ERIC Educational Resources Information Center

Sheets, Robert G.; Crawford, Stephen

2012-01-01

Higher education is under enormous pressure to improve outcomes and reduce costs. Information technology can help achieve these goals, but only if it is properly harnessed. This article argues that one key to harnessing information technology is business model innovation that results in more "open" and "unbundled" operations in learning and…

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

78 FR 57784 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-20

... certain wire harness located in the tail cone has wiring of a narrower gauge than design requires. This AD requires replacing the affected wire harness. We are issuing this AD to prevent damage to the affected... production aeroplane, it has been discovered that wires in harness 5877VB, installed in the Tail Cone...

75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... pump wire harness assembly is routed within the tire burst area and that installing and routing a new and longer auxiliary hydraulic pump wire harness assembly outside the tire burst area will minimize... general visual inspection of the wire harness protective sleeving dimensions, which are related...

Divide and Conquer-Based 1D CNN Human Activity Recognition Using Test Data Sharpening †

PubMed Central

Yoon, Sang Min

2018-01-01

Human Activity Recognition (HAR) aims to identify the actions performed by humans using signals collected from various sensors embedded in mobile devices. In recent years, deep learning techniques have further improved HAR performance on several benchmark datasets. In this paper, we propose one-dimensional Convolutional Neural Network (1D CNN) for HAR that employs a divide and conquer-based classifier learning coupled with test data sharpening. Our approach leverages a two-stage learning of multiple 1D CNN models; we first build a binary classifier for recognizing abstract activities, and then build two multi-class 1D CNN models for recognizing individual activities. We then introduce test data sharpening during prediction phase to further improve the activity recognition accuracy. While there have been numerous researches exploring the benefits of activity signal denoising for HAR, few researches have examined the effect of test data sharpening for HAR. We evaluate the effectiveness of our approach on two popular HAR benchmark datasets, and show that our approach outperforms both the two-stage 1D CNN-only method and other state of the art approaches. PMID:29614767

Divide and Conquer-Based 1D CNN Human Activity Recognition Using Test Data Sharpening.

PubMed

Cho, Heeryon; Yoon, Sang Min

2018-04-01

Human Activity Recognition (HAR) aims to identify the actions performed by humans using signals collected from various sensors embedded in mobile devices. In recent years, deep learning techniques have further improved HAR performance on several benchmark datasets. In this paper, we propose one-dimensional Convolutional Neural Network (1D CNN) for HAR that employs a divide and conquer-based classifier learning coupled with test data sharpening. Our approach leverages a two-stage learning of multiple 1D CNN models; we first build a binary classifier for recognizing abstract activities, and then build two multi-class 1D CNN models for recognizing individual activities. We then introduce test data sharpening during prediction phase to further improve the activity recognition accuracy. While there have been numerous researches exploring the benefits of activity signal denoising for HAR, few researches have examined the effect of test data sharpening for HAR. We evaluate the effectiveness of our approach on two popular HAR benchmark datasets, and show that our approach outperforms both the two-stage 1D CNN-only method and other state of the art approaches.

Manufacture and quality control of interconnecting wire hardnesses, Volume 1

NASA Technical Reports Server (NTRS)

1972-01-01

A standard is presented for manufacture, installation, and quality control of eight types of interconnecting wire harnesses. The processes, process controls, and inspection and test requirements reflected are based on acknowledgment of harness design requirements, acknowledgment of harness installation requirements, identification of the various parts, materials, etc., utilized in harness manufacture, and formulation of a typical manufacturing flow diagram for identification of each manufacturing and quality control process, operation, inspection, and test. The document covers interconnecting wire harnesses defined in the design standard, including type 1, enclosed in fluorocarbon elastomer convolute, tubing; type 2, enclosed in TFE convolute tubing lines with fiberglass braid; type 3, enclosed in TFE convolute tubing; and type 5, combination of types 3 and 4. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated.

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

75 FR 47201 - Airworthiness Directives; Eurocopter France Model EC 130 B4 Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-05

... each electrical harness for chaffing, tears, holes, or other damage at the location of each attachment... electrical harness for any chaffing, tear, hole, or other damage at the location of each attachment screw and... harness for chaffing, a tear, a hole, or other damage at the location of each attachment screw as depicted...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

75 FR 30274 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... installed on wire harnesses of the tail tank fuel transfer pumps, and to determine if damaged wires are... a permanent modification of the wire harnesses if metallic transitions are not installed, which... harnesses of the tail tank fuel transfer pumps, and to determine if damaged wires are present; and repair...

75 FR 81433 - Airworthiness Directives; Airbus Model A321-211, -212, -231, and -232 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... join individual electrical wires in the Wing Tank harness installations to in-tank equipment on QT... are used to join individual electrical wires in the Wing Tank harness installations to in-tank... electrical wires in the Wing Tank harness installations to in-tank equipment on QT circuit. The failure of a...

Alternative Fuels Data Center: Fair Oaks Farm Harnesses the Power of

Science.gov Websites

Natural Gas from Cow Manure Fair Oaks Farm Harnesses the Power of Natural Gas from Cow Manure Natural Gas from Cow Manure on Facebook Tweet about Alternative Fuels Data Center: Fair Oaks Farm Harnesses the Power of Natural Gas from Cow Manure on Twitter Bookmark Alternative Fuels Data Center: Fair

75 FR 28478 - Airworthiness Directives; Eurocopter France (ECF) Model AS332L1 and AS332L2 Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... fully tilted the seat shoulder harness could become jammed between the seat and bulkhead. This condition, if not corrected, could result in the shoulder harness binding and causing the inertial reel to... seat backrest is fully tilted, there is a risk of the shoulder harness jamming between the seat and...

75 FR 20423 - Fuji Heavy Industries USA, Inc., Receipt of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... power supply to the lamp. The Company said that ``installation of the wiring harness to the... subsupplier such that tension was put on the wiring harness connector'' which can cause it to come loose. To correct this problem, the Company has re-routed the wiring harness to ``push'' rather than ``pull'' on the...

Reliability and Validity of the Zephyr[TM] BioHarness[TM] to Measure Respiratory Responses to Exercise

ERIC Educational Resources Information Center

Hailstone, Jono; Kilding, Andrew E.

2011-01-01

The Zephyr[TM] BioHarness[TM] (Zephyr Technology, Auckland, New Zealand) is a wireless physiological monitoring system that has the ability to measure respiratory rate unobtrusively. However, the ability of the BioHarness[TM] to accurately and reproducibly determine respiratory rate across a range of intensities is currently unknown. The aim of…

Wire harness twisting aid

NASA Technical Reports Server (NTRS)

Casey, E. J.; Commadore, C. C.; Ingles, M. E.

1980-01-01

Long wire bundles twist into uniform spiral harnesses with help of simple apparatus. Wires pass through spacers and through hand-held tool with hole for each wire. Ends are attached to low speed bench motor. As motor turns, operator moves hand tool away forming smooth twists in wires between motor and tool. Technique produces harnesses that generate less radio-frequency interference than do irregularly twisted cables.

Manufacturing and quality control of interconnecting wire harnesses, Volume 4

NASA Technical Reports Server (NTRS)

1972-01-01

The document covers interconnecting wire harnesses defined in the design standard, including type 8, flat conductor cable. Volume breadth covers installations of groups of harnesses in a major assembly and the associated post installation inspections and electrical tests. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into this document.

Circuit For Control Of Electromechanical Prosthetic Hand

NASA Technical Reports Server (NTRS)

Bozeman, Richard J., Jr.

1995-01-01

Proposed circuit for control of electromechanical prosthetic hand derives electrical control signals from shoulder movements. Updated, electronic version of prosthesis, that includes two hooklike fingers actuated via cables from shoulder harness. Circuit built around favored shoulder harness, provides more dexterous movement, without incurring complexity of computer-controlled "bionic" or hydraulically actuated devices. Additional harness and potentiometer connected to similar control circuit mounted on other shoulder. Used to control stepping motor rotating hand about prosthetic wrist to one of number of angles consistent with number of digital outputs. Finger-control signals developed by circuit connected to first shoulder harness transmitted to prosthetic hand via sliprings at prosthetic wrist joint.

Effects of backpack radiotags on female northern pintails wintering in California

USGS Publications Warehouse

Fleskes, Joseph P.

2003-01-01

To test whether backpack radiotags impacted the wintering biology of northern pintails (Anas acuta), I attached spear-suture (SSU, n=82 in 1993) or harness (HAR, n=337 in 1991-1993) backpack radiotags to female Hatch-Year (HY) and After-Hatch-Year (AHY) pintails after their autumn arrival in California. I evaluated impacts of radiotags on 1) wintering population distribution; 2) flock status, flock size, and body mass at harvest; and 3) August-March survival. I also compared retention of SSU and HAR following attachment. Distribution, flock status, and flock size at harvest of HAR, SSU, and unmarked (UMK) pintails were similar. However, harvest mass of HAR pintails averaged 1 33 g (SE=25 g) less than UMK pintails; loss tended to be greatest for heavier HY females in 1 993. Daily survival rates during 1 993-1 994 of HAR vs. SSU pintails were similar for both HY (0.9979 vs. 0.9974) and AHY (0.9988 vs. 0.9986) female pintails. Retention ranged from 30-1 58 days (x=81 d, SE=5 d) for the 37 SSU that I confirmed as being shed; all other SSU failed 1-month studies due to poor retention past a month.

Formation of the world's largest REE deposit through protracted fluxing of carbonatite by subduction-derived fluids

PubMed Central

Ling, Ming-Xing; Liu, Yu-Long; Williams, Ian S.; Teng, Fang-Zhen; Yang, Xiao-Yong; Ding, Xing; Wei, Gang-Jian; Xie, Lu-Hua; Deng, Wen-Feng; Sun, Wei-Dong

2013-01-01

Rare Earth Elements (REE) are essential to modern society but the origins of many large REE deposits remain unclear. The U-Th-Pb ages, chemical compositions and C, O and Mg isotopic compositions of Bayan Obo, the world's largest REE deposit, indicate a protracted mineralisation history with unusual chemical and isotopic features. Coexisting calcite and dolomite are in O isotope disequilibrium; some calcitic carbonatite samples show highly varied δ26Mg which increases with increasing Si and Mg; and ankerite crystals show decreases in Fe and REE from rim to centre, with highly varied REE patterns. These and many other observations are consistent with an unusual mineralisation process not previously considered; protracted fluxing of calcitic carbonatite by subduction-released high-Si fluids during the closure of the Palaeo-Asian Ocean. The fluids leached Fe and Mg from the mantle wedge and scavenged REE, Nb and Th from carbonatite, forming the deposit through metasomatism of overlying sedimentary carbonate.

Analysis of the Source System of Nantun Group in Huhehu Depression of Hailar Basin

NASA Astrophysics Data System (ADS)

Li, Yue; Li, Junhui; Wang, Qi; Lv, Bingyang; Zhang, Guannan

2017-10-01

Huhehu Depression will be the new battlefield in Hailar Basin in the future, while at present it’s in a low exploration level. The study about the source system of Nantun group is little, so fine depiction of the source system would be significant to sedimentary system reconstruction, the reservoir distribution and prediction of favorable area. In this paper, it comprehensive uses of many methods such as ancient landform, light and heavy mineral combination, seismic reflection characteristics, to do detailed study about the source system of Nantun group in different views and different levels. The results show that the source system in Huhehu Depression is from the east of Xilinbeir bulge and the west of Bayan Moutain uplift, which is surrounded by basin. The slope belt is the main source, and the southern bulge is the secondary source. The distribution of source system determines the distribution of sedimentary system and the regularity of the distribution of sand body.

Pattern of homicidal deaths autopsied at Penang Hospital, Malaysia, 2007-2009: a preliminary study.

PubMed

Bhupinder, S; Kumara, T K; Syed, A M

2010-12-01

This article describes the homicide pattern in Penang Island, Malaysia over a three-year period (2007-2009). 65 homicide autopsies were performed at the Department of Forensic Medicine, Penang Hospital over the study period. The homicide rates ranged from 0.01 to 0.09/1000 population, the highest being in the Indian ethnic group. The majority (37%) of victims were in the 20-39 years age group. The male: female ratio was 3:1. The majority of deaths were caused by blunt instruments (46%), followed by stab/slash wounds (25%) and asphyxiation (12%). 63% of homicides occurred in areas served by the police stations at Jalan Patani (23.1%), Sg. Nibong (16.9%), Central (12.3%) and Bayan Lepas (10.9%). 56 (86%) victims were brought in dead to the hospital, while 9 (14%) died after admission. Most (39%) incidences occurred in the morning. The methods of homicide were different from Kuala Lumpur, another highly urbanised area of Malaysia.

Immunotherapy and gene therapy as novel treatments for cancer

PubMed Central

Rangel-Sosa, Martha Montserrat; Aguilar-Córdova, Estuardo

2017-01-01

Abstract The immune system interacts closely with tumors during the disease development and progression to metastasis. The complex communication between the immune system and the tumor cells can prevent or promote tumor growth. New therapeutic approaches harnessing protective immunological mechanisms have recently shown very promising results. This is performed by blocking inhibitory signals or by activating immunological effector cells directly. Immune checkpoint blockade with monoclonal antibodies directed against the inhibitory immune receptors CTLA-4 and PD-1 has emerged as a successful treatment approach for patients with advanced melanoma. Ipilimumab is an anti-CTLA-4 antibody which demonstrated good results when administered to patients with melanoma. Gene therapy has also shown promising results in clinical trials. Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor. The development of new treatment strategies or combination of available innovative therapies to improve cell cytotoxic T lymphocytes trafficking into the tumor mass and the production of inhibitory molecules blocking tumor tissue immune-tolerance are crucial to improve the efficacy of cancer therapy. PMID:29213157

Forecasting the value-at-risk of Chinese stock market using the HARQ model and extreme value theory

NASA Astrophysics Data System (ADS)

Liu, Guangqiang; Wei, Yu; Chen, Yongfei; Yu, Jiang; Hu, Yang

2018-06-01

Using intraday data of the CSI300 index, this paper discusses value-at-risk (VaR) forecasting of the Chinese stock market from the perspective of high-frequency volatility models. First, we measure the realized volatility (RV) with 5-minute high-frequency returns of the CSI300 index and then model it with the newly introduced heterogeneous autoregressive quarticity (HARQ) model, which can handle the time-varying coefficients of the HAR model. Second, we forecast the out-of-sample VaR of the CSI300 index by combining the HARQ model and extreme value theory (EVT). Finally, using several popular backtesting methods, we compare the VaR forecasting accuracy of HARQ model with other traditional HAR-type models, such as HAR, HAR-J, CHAR, and SHAR. The empirical results show that the novel HARQ model can beat other HAR-type models in forecasting the VaR of the Chinese stock market at various risk levels.

A Regulatory Pathway, Ecdysone-Transcription Factor Relish-Cathepsin L, Is Involved in Insect Fat Body Dissociation

PubMed Central

Zhang, Yao; Lu, Yu-Xuan; Liu, Jian; Yang, Cui; Feng, Qi-Li; Xu, Wei-Hua

2013-01-01

Insect fat body is the organ for intermediary metabolism, comparable to vertebrate liver and adipose tissue. Larval fat body is disintegrated to individual fat body cells and then adult fat body is remodeled at the pupal stage. However, little is known about the dissociation mechanism. We find that the moth Helicoverpa armigera cathepsin L (Har-CL) is expressed heavily in the fat body and is released from fat body cells into the extracellular matrix. The inhibitor and RNAi experiments demonstrate that Har-CL functions in the fat body dissociation in H. armigera. Further, a nuclear protein is identified to be transcription factor Har-Relish, which was found in insect immune response and specifically binds to the promoter of Har-CL gene to regulate its activity. Har-Relish also responds to the steroid hormone ecdysone. Thus, the dissociation of the larval fat body is involved in the hormone (ecdysone)-transcription factor (Relish)-target gene (cathepsin L) regulatory pathway. PMID:23459255

Harnessing the Power of Light to See and Treat Breast Cancer

DTIC Science & Technology

2010-10-01

Harnessing the power of light to see and treat breast cancer PRINCIPAL INVESTIGATOR: Nirmala Ramanujam, Ph.D...NUMBER Harnessing the power of light to see and treat breast cancer . 5b. GRANT NUMBER W81XWH-09-1-0410 5c. PROGRAM ELEMENT NUMBER 6...optical contrast to develop novel strategies that focus on two breast cancer applications: tumor margin assessment and prediction of response to neo

Evaluation of Cable Harness Post-Installation Testing. Part B

NASA Technical Reports Server (NTRS)

King, M. S.; Iannello, C. J.

2011-01-01

The Cable Harness Post-Installation Testing Report was written in response to an action issued by the Ares Project Control Board (PCB). The action for the Ares I Avionics & Software Chief Engineer and the Avionics Integration and Vehicle Systems Test Work Breakdown Structure (WBS) Manager in the Vehicle Integration Office was to develop a set of guidelines for electrical cable harnesses. Research showed that post-installation tests have been done since the Apollo era. For Ares I-X, the requirement for post-installation testing was removed to make it consistent with the avionics processes used on the Atlas V expendable launch vehicle. Further research for the report involved surveying government and private sector launch vehicle developers, military and commercial aircraft, spacecraft developers, and harness vendors. Responses indicated crewed launch vehicles and military aircraft perform post-installation tests. Key findings in the report were as follows: Test requirements identify damage, human-rated vehicles should be tested despite the identification of statistically few failures, data does not support the claim that post-installation testing damages the harness insulation system, and proper planning can reduce overhead associated with testing. The primary recommendation of the report is for the Ares projects to retain the practice of post-fabrication and post-installation cable harness testing.

Sharp-Tip Silver Nanowires Mounted on Cantilevers for High-Aspect-Ratio High-Resolution Imaging.

PubMed

Ma, Xuezhi; Zhu, Yangzhi; Kim, Sanggon; Liu, Qiushi; Byrley, Peter; Wei, Yang; Zhang, Jin; Jiang, Kaili; Fan, Shoushan; Yan, Ruoxue; Liu, Ming

2016-11-09

Despite many efforts to fabricate high-aspect-ratio atomic force microscopy (HAR-AFM) probes for high-fidelity, high-resolution topographical imaging of three-dimensional (3D) nanostructured surfaces, current HAR probes still suffer from unsatisfactory performance, low wear-resistivity, and extravagant prices. The primary objective of this work is to demonstrate a novel design of a high-resolution (HR) HAR AFM probe, which is fabricated through a reliable, cost-efficient benchtop process to precisely implant a single ultrasharp metallic nanowire on a standard AFM cantilever probe. The force-displacement curve indicated that the HAR-HR probe is robust against buckling and bending up to 150 nN. The probes were tested on polymer trenches, showing a much better image fidelity when compared with standard silicon tips. The lateral resolution, when scanning a rough metal thin film and single-walled carbon nanotubes (SW-CNTs), was found to be better than 8 nm. Finally, stable imaging quality in tapping mode was demonstrated for at least 15 continuous scans indicating high resistance to wear. These results demonstrate a reliable benchtop fabrication technique toward metallic HAR-HR AFM probes with performance parallel or exceeding that of commercial HAR probes, yet at a fraction of their cost.

Advances and limitations of visual conditioning protocols in harnessed bees.

PubMed

Avarguès-Weber, Aurore; Mota, Theo

2016-10-01

Bees are excellent invertebrate models for studying visual learning and memory mechanisms, because of their sophisticated visual system and impressive cognitive capacities associated with a relatively simple brain. Visual learning in free-flying bees has been traditionally studied using an operant conditioning paradigm. This well-established protocol, however, can hardly be combined with invasive procedures for studying the neurobiological basis of visual learning. Different efforts have been made to develop protocols in which harnessed honey bees could associate visual cues with reinforcement, though learning performances remain poorer than those obtained with free-flying animals. Especially in the last decade, the intention of improving visual learning performances of harnessed bees led many authors to adopt distinct visual conditioning protocols, altering parameters like harnessing method, nature and duration of visual stimulation, number of trials, inter-trial intervals, among others. As a result, the literature provides data hardly comparable and sometimes contradictory. In the present review, we provide an extensive analysis of the literature available on visual conditioning of harnessed bees, with special emphasis on the comparison of diverse conditioning parameters adopted by different authors. Together with this comparative overview, we discuss how these diverse conditioning parameters could modulate visual learning performances of harnessed bees. Copyright © 2016 Elsevier Ltd. All rights reserved.

Pharmacological modulation of aversive responsiveness in honey bees

PubMed Central

Tedjakumala, Stevanus R.; Aimable, Margaux; Giurfa, Martin

2014-01-01

Within a honey bee colony, individuals performing different tasks exhibit different sensitivities to noxious stimuli. Noxious-stimulus sensitivity can be quantified in harnessed bees by measuring the sting extension response (SER) to a series of increasing voltages. Biogenic amines play a crucial role in the control of insect responsiveness. Whether or not these neurotransmitters affect the central control of aversive responsiveness, and more specifically of electric-shock responsiveness, remains unknown. Here we studied the involvement of the biogenic amines octopamine, dopamine and serotonin, and of the ecdysteroid 20-hydroxyecdisone in the central control of sting responsiveness to electric shocks. We injected pharmacological antagonists of these signaling pathways into the brain of harnessed bees and determined the effect of blocking these different forms of neurotransmission on shock responsiveness. We found that both octopamine and 20-hydroxyecdisone are dispensable for shock responsiveness while dopamine and serotonin act as down-regulators of sting responsiveness. As a consequence, antagonists of these two biogenic amines induce an increase in shock responsiveness to shocks of intermediate voltage; serotonin, can also increase non-specific responsiveness. We suggest that different classes of dopaminergic neurons exist in the bee brain and we define at least two categories: an instructive class mediating aversive labeling of conditioned stimuli in associative learning, and a global gain-control class which down-regulates responsiveness upon perception of noxious stimuli. Serotonergic signaling together with down-regulating dopaminergic signaling may play an essential role in attentional processes by suppressing responses to irrelevant, non-predictive stimuli, thereby allowing efficient behavioral performances. PMID:24431993

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.

PubMed

Abbott, Jamie A; Guth, Ethan; Kim, Cindy; Regan, Cathy; Siu, Victoria M; Rupar, C Anthony; Demeler, Borries; Francklyn, Christopher S; Robey-Bond, Susan M

2017-07-18

Histidyl-tRNA synthetase (HARS) is a highly conserved translation factor that plays an essential role in protein synthesis. HARS has been implicated in the human syndromes Charcot-Marie-Tooth (CMT) Type 2W and Type IIIB Usher (USH3B). The USH3B mutation, which encodes a Y454S substitution in HARS, is inherited in an autosomal recessive fashion and associated with childhood deafness, blindness, and episodic hallucinations during acute illness. The biochemical basis of the pathophysiologies linked to USH3B is currently unknown. Here, we present a detailed functional comparison of wild-type (WT) and Y454S HARS enzymes. Kinetic parameters for enzymes and canonical substrates were determined using both steady state and rapid kinetics. Enzyme stability was examined using differential scanning fluorimetry. Finally, enzyme functionality in a primary cell culture was assessed. Our results demonstrate that the Y454S substitution leaves HARS amino acid activation, aminoacylation, and tRNA His binding functions largely intact compared with those of WT HARS, and the mutant enzyme dimerizes like the wild type does. Interestingly, during our investigation, it was revealed that the kinetics of amino acid activation differs from that of the previously characterized bacterial HisRS. Despite the similar kinetics, differential scanning fluorimetry revealed that Y454S is less thermally stable than WT HARS, and cells from Y454S patients grown at elevated temperatures demonstrate diminished levels of protein synthesis compared to those of WT cells. The thermal sensitivity associated with the Y454S mutation represents a biochemical basis for understanding USH3B.

Probing the accuracy and precision of Hirshfeld atom refinement with HARt interfaced with Olex2.

PubMed

Fugel, Malte; Jayatilaka, Dylan; Hupf, Emanuel; Overgaard, Jacob; Hathwar, Venkatesha R; Macchi, Piero; Turner, Michael J; Howard, Judith A K; Dolomanov, Oleg V; Puschmann, Horst; Iversen, Bo B; Bürgi, Hans-Beat; Grabowsky, Simon

2018-01-01

Hirshfeld atom refinement (HAR) is a novel X-ray structure refinement technique that employs aspherical atomic scattering factors obtained from stockholder partitioning of a theoretically determined tailor-made static electron density. HAR overcomes many of the known limitations of independent atom modelling (IAM), such as too short element-hydrogen distances, r ( X -H), or too large atomic displacement parameters (ADPs). This study probes the accuracy and precision of anisotropic hydrogen and non-hydrogen ADPs and of r ( X -H) values obtained from HAR. These quantities are compared and found to agree with those obtained from (i) accurate neutron diffraction data measured at the same temperatures as the X-ray data and (ii) multipole modelling (MM), an established alternative method for interpreting X-ray diffraction data with the help of aspherical atomic scattering factors. Results are presented for three chemically different systems: the aromatic hydro-carbon rubrene (orthorhombic 5,6,11,12-tetra-phenyl-tetracene), a co-crystal of zwitterionic betaine, imidazolium cations and picrate anions (BIPa), and the salt potassium hydrogen oxalate (KHOx). The non-hydrogen HAR-ADPs are as accurate and precise as the MM-ADPs. Both show excellent agreement with the neutron-based values and are superior to IAM-ADPs. The anisotropic hydrogen HAR-ADPs show a somewhat larger deviation from neutron-based values than the hydrogen SHADE-ADPs used in MM. Element-hydrogen bond lengths from HAR are in excellent agreement with those obtained from neutron diffraction experiments, although they are somewhat less precise. The residual density contour maps after HAR show fewer features than those after MM. Calculating the static electron density with the def2-TZVP basis set instead of the simpler def2-SVP one does not improve the refinement results significantly. All HARs were performed within the recently introduced HARt option implemented in the Olex2 program. They are easily launched inside its graphical user interface following a conventional IAM.

Minimizing marker mass and handling time when attaching radio-transmitters and geolocators to small songbirds

USGS Publications Warehouse

Streby, Henry M.; McAllister, Tara L.; Peterson, Sean M.; Kramer, Gunnar R.; Lehman, Justin A.; Andersen, David E.

2015-01-01

Radio-transmitters and light-level geolocators are currently small enough for use on songbirds weighing <15 g. Various methods are used to attach these markers to larger songbirds, but with small birds it becomes especially important to minimize marker mass and bird handling time. Here, we offer modifications to harness materials and marker preparation for transmitters and geolocators, and we describe deployment methods that can be safely completed in 20–60 s per bird. We describe a 0.5-mm elastic sewing thread harness for radio-transmitters that allows nestlings, fledglings, and adults to be marked with the same harness size and reliably falls off to avoid poststudy effects. We also describe a 0.5-mm jewelry cord harness for geolocators that provides a firm fit for >1 yr. Neither harness type requires plastic or metal tubes, rings, or other attachment fixtures on the marker, nor do they require crimping beads, epoxy, scissors, or tying knots while handling birds. Both harnesses add 0.03 g to the mass of markers for small wood-warblers (Parulidae). This minimal additional mass is offset by trimming transmitter antennas or geolocator connection nodes, resulting in no net mass gain for transmitters and 0.02 g added for geolocators compared with conventional harness methods that add >0.40 g. We and others have used this transmitter attachment method with several small songbird species, with no effects on adult and fledgling behavior and survival. We have used this geolocator attachment method on 9-g wood-warblers with no effects on return rates, return dates, territory fidelity, and body mass. We hope that these improvements to the design and deployment of the leg-loop harness method will enable the safe and successful use of these markers, and eventually GPS and other tags, on similarly small songbirds.

Probing the accuracy and precision of Hirshfeld atom refinement with HARt interfaced with Olex2

PubMed Central

Fugel, Malte; Hathwar, Venkatesha R.; Turner, Michael J.; Howard, Judith A. K.

2018-01-01

Hirshfeld atom refinement (HAR) is a novel X-ray structure refinement technique that employs aspherical atomic scattering factors obtained from stockholder partitioning of a theoretically determined tailor-made static electron density. HAR overcomes many of the known limitations of independent atom modelling (IAM), such as too short element–hydrogen distances, r(X—H), or too large atomic displacement parameters (ADPs). This study probes the accuracy and precision of anisotropic hydrogen and non-hydrogen ADPs and of r(X—H) values obtained from HAR. These quantities are compared and found to agree with those obtained from (i) accurate neutron diffraction data measured at the same temperatures as the X-ray data and (ii) multipole modelling (MM), an established alternative method for interpreting X-ray diffraction data with the help of aspherical atomic scattering factors. Results are presented for three chemically different systems: the aromatic hydro­carbon rubrene (orthorhombic 5,6,11,12-tetra­phenyl­tetracene), a co-crystal of zwitterionic betaine, imidazolium cations and picrate anions (BIPa), and the salt potassium hydrogen oxalate (KHOx). The non-hydrogen HAR-ADPs are as accurate and precise as the MM-ADPs. Both show excellent agreement with the neutron-based values and are superior to IAM-ADPs. The anisotropic hydrogen HAR-ADPs show a somewhat larger deviation from neutron-based values than the hydrogen SHADE-ADPs used in MM. Element–hydrogen bond lengths from HAR are in excellent agreement with those obtained from neutron diffraction experiments, although they are somewhat less precise. The residual density contour maps after HAR show fewer features than those after MM. Calculating the static electron density with the def2-TZVP basis set instead of the simpler def2-SVP one does not improve the refinement results significantly. All HARs were performed within the recently introduced HARt option implemented in the Olex2 program. They are easily launched inside its graphical user interface following a conventional IAM. PMID:29354269

Spatially resolved, substrate-induced rectification in C 60 bilayers on copper

DOE PAGES

Smerdon, J. A.; Darancet, P.; Guest, J. R.

2017-02-22

Here, we demonstrate rectification ratios ( RR) of ≳1000 at biases of 1.3 V in bilayers of C 60 deposited on copper. Using scanning tunneling spectroscopy and first-principles calculations, we show that the strong coupling between C 60 and the Cu(111) surface leads to the metallization of the bottom C 60 layer, while the molecular orbitals of the top C60 are essentially unaffected. Due to this substrate-induced symmetry breaking and to a tunneling transport mechanism, the system behaves as a hole-blocking layer, with a spatial dependence of the onset voltage on intra-layer coordination. Together with previous observations of strong electron-blockingmore » character of pentacene/C 60 bilayers on Cu(111), this work further demonstrates the potential of strongly hybridized, C 60-coated electrodes to harness the electrical functionality of molecular components.« less

Reinventing solid state electronics: Harnessing quantum confinement in bismuth thin films

NASA Astrophysics Data System (ADS)

Gity, Farzan; Ansari, Lida; Lanius, Martin; Schüffelgen, Peter; Mussler, Gregor; Grützmacher, Detlev; Greer, J. C.

2017-02-01

Solid state electronics relies on the intentional introduction of impurity atoms or dopants into a semiconductor crystal and/or the formation of junctions between different materials (heterojunctions) to create rectifiers, potential barriers, and conducting pathways. With these building blocks, switching and amplification of electrical currents and voltages are achieved. As miniaturisation continues to ultra-scaled transistors with critical dimensions on the order of ten atomic lengths, the concept of doping to form junctions fails and forming heterojunctions becomes extremely difficult. Here, it is shown that it is not needed to introduce dopant atoms nor is a heterojunction required to achieve the fundamental electronic function of current rectification. Ideal diode behavior or rectification is achieved solely by manipulation of quantum confinement using approximately 2 nm thick films consisting of a single atomic element, the semimetal bismuth. Crucially for nanoelectronics, this approach enables room temperature operation.

Harnessing Students' Interest in Physics with Their Own Video Games

NASA Astrophysics Data System (ADS)

Like, Christopher

2011-04-01

Many physics teachers assign projects where students are asked to measure real-world motion. One purpose of this student-centered activity is to cultivate the relevance of physics in their lives. Typical project topics may include measuring the speed of a student's fastball and calculating how much reaction time batters are given. Another student may find the trajectory of her dive off the blocks at the pool and its effect on race time. Leaving the experimental design to the student's imagination allows for a variety of proposals ranging from stopwatches to highly technical video analysis. The past few years have shown an increase in students' eagerness to tackle the physics behind the motion of virtual characters and phenomena in their own video games. This paper puts forth a method of analyzing the physics behind bringing the games students are playing for enjoyment into the physics classroom.

Towards a better life for the young workers. An education project in Malaysia.

PubMed

Knutsen, K

1978-06-01

Attention in this discussion focuses on Malaysia's education project, the Young Workers Community Education Project (YWCEP). At the Community Hall of Bayan Lepas, the YWCEP Center, about 60 local residents with more than half of them young industrial workers, are gathered for a half day forum on a Sunday morning. The subject is the current statewide industrial development program and its socioeconomic implications for the local community. The 2nd scene is at the Project Center on a Wednesday afternoon. 1 of 3 conversational English classes is in session. The 3rd scene is a bus carrying more than 30 young workers on a trip. The final scene is at a hostel provided by 1 of the factories for its workers. It is an opportunity for young workers to talk about their problems at work and to seek information on the ongoing activities sponsored by the Project. At first glance these programs and activities appear the same as those organized by similar service groups throughout industrial complexes in Malaysia over the past 5-10 years. What makes the YWCEP different and exciting is the approach to the problem of facilitating "A Better Life for Young Workers." The Project views the lives of the workers as a whole. This is reflected in the project design which attempts to relate the economic, the social, and the environmental dimensions of their lives in 1 integrated net of work modules. 1 basic goal of the Project is to facilitate individual participation in group activities, since this has been identified as a crucial need of the target group. The YWCEP is based on the conviction that the participants themselves must be involved at all levels of the Project operation, including planning and evaluation. The Project aims at being instrumental in bridging the gap between the young workers and the rest of the community. The YWCEP was conceived as a positive response to the many problems created by the rapid industrialization in the Bayan Lepas area of Penang in the early 1970s. The Federation of Family Planning Associations conducted a survey in 1974 to examine the situation with the objective of suggesting possible remedial action. In December 1975 a pilot community service project was launched, confirming the need for such a project. YWCEP was launched in 1977 and is now fully operational. It has gained the cooperation and respect of the young workers.

Compliant walker

NASA Technical Reports Server (NTRS)

Kerley, James J. (Inventor); Eklund, Wayne D. (Inventor); Crane, J. Allen (Inventor)

1992-01-01

A compliant walker is provided for humans having limited use of their legs and lower back. It includes an upright wheel frame which at least partially surrounds an upright user wearing a partial body harness. It is attached to the frame by means of cable compliant apparatus consisting of sets of cable segments and angle bracket members connected between opposite side members of the frame and adjacent side portions of the harness. Novelty is believed to exist in the combination of a wheeled frame including a side support structure, a body harness, and compliance means connecting the body harness to the side support structure for flexibility holding and supporting a person in a substantially upright position when the user sags in the frame when taking weight off the lower extremities.

Effects of satellite transmitters on captive and wild mallards

USGS Publications Warehouse

Kesler, Dylan C.; Raedeke, Andrew H.; Foggia, Jennifer R.; Beatty, William S.; Webb, Elisabeth B.; Humburg, Dale D.; Naylor, Luke W.

2014-01-01

Satellite telemetry has become a leading method for studying large-scale movements and survival in birds, yet few have addressed potential effects of the larger and heavier tracking equipment on study subjects. We simultaneously evaluated effects of satellite telemetry equipment on captive and wild mallards (Anas platyrhynchos) to assess impacts on behavior, body mass, and movement. We randomly assigned 55 captive ducks to one of 3 treatment groups, including a standard body harness group, a modified harness group, and a control group. Ducks in the control group were not fitted with equipment, whereas individuals in the other 2 groups were fitted with dummy transmitters attached with a Teflon ribbon harness or with a similar harness constructed of nylon cord. At the conclusion of the 14-week captive study, mean body mass of birds in the control group was 40–105 g (95% CI) greater than birds with standard harnesses, and 28–99 g (95% CI) greater than birds with modified harnesses. Further, results of focal behavior observations indicated ducks with transmitters were less likely to be in water than control birds. We also tested whether movements of wild birds marked with a similar Teflon harness satellite transmitter aligned with population movements reported by on-the-ground observers who indexed local abundances of mid-continent mallards throughout the non-breeding period. Results indicated birds marked with satellite transmitters moved concurrently with the larger unmarked population. Our results have broad implications for field research and suggest that investigators should consider potential for physiological and behavioral effects brought about by tracking equipment. Nonetheless, results from wild ducks indicate satellite telemetry has the potential to provide useful movement data.

Development of termination and utilization concepts for flat conductor cables. Volume 2: Utilization of small gage wire round conductor cables

NASA Technical Reports Server (NTRS)

1972-01-01

The practical use of small-gage round wire for electrical wiring in manned air and space vehicle environments is discussed. The investigation consisted on a study of wire construction and candidate wire harness concepts, fabrication of small-gage wire harnesses, and verification of promising configurations by laboratory evaluation. The wire constructions selected for harness fabrication are described. Results of the laboratory evaluation are included.

Design methodology: edgeless 3D ASICs with complex in-pixel processing for pixel detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fahim Farah, Fahim Farah; Deptuch, Grzegorz W.; Hoff, James R.

The design methodology for the development of 3D integrated edgeless pixel detectors with in-pixel processing using Electronic Design Automation (EDA) tools is presented. A large area 3 tier 3D detector with one sensor layer and two ASIC layers containing one analog and one digital tier, is built for x-ray photon time of arrival measurement and imaging. A full custom analog pixel is 65μm x 65μm. It is connected to a sensor pixel of the same size on one side, and on the other side it has approximately 40 connections to the digital pixel. A 32 x 32 edgeless array withoutmore » any peripheral functional blocks constitutes a sub-chip. The sub-chip is an indivisible unit, which is further arranged in a 6 x 6 array to create the entire 1.248cm x 1.248cm ASIC. Each chip has 720 bump-bond I/O connections, on the back of the digital tier to the ceramic PCB. All the analog tier power and biasing is conveyed through the digital tier from the PCB. The assembly has no peripheral functional blocks, and hence the active area extends to the edge of the detector. This was achieved by using a few flavors of almost identical analog pixels (minimal variation in layout) to allow for peripheral biasing blocks to be placed within pixels. The 1024 pixels within a digital sub-chip array have a variety of full custom, semi-custom and automated timing driven functional blocks placed together. The methodology uses a modified mixed-mode on-top digital implementation flow to not only harness the tool efficiency for timing and floor-planning but also to maintain designer control over compact parasitically aware layout. The methodology uses the Cadence design platform, however it is not limited to this tool.« less

Design methodology: edgeless 3D ASICs with complex in-pixel processing for pixel detectors

NASA Astrophysics Data System (ADS)

Fahim, Farah; Deptuch, Grzegorz W.; Hoff, James R.; Mohseni, Hooman

2015-08-01

The design methodology for the development of 3D integrated edgeless pixel detectors with in-pixel processing using Electronic Design Automation (EDA) tools is presented. A large area 3 tier 3D detector with one sensor layer and two ASIC layers containing one analog and one digital tier, is built for x-ray photon time of arrival measurement and imaging. A full custom analog pixel is 65μm x 65μm. It is connected to a sensor pixel of the same size on one side, and on the other side it has approximately 40 connections to the digital pixel. A 32 x 32 edgeless array without any peripheral functional blocks constitutes a sub-chip. The sub-chip is an indivisible unit, which is further arranged in a 6 x 6 array to create the entire 1.248cm x 1.248cm ASIC. Each chip has 720 bump-bond I/O connections, on the back of the digital tier to the ceramic PCB. All the analog tier power and biasing is conveyed through the digital tier from the PCB. The assembly has no peripheral functional blocks, and hence the active area extends to the edge of the detector. This was achieved by using a few flavors of almost identical analog pixels (minimal variation in layout) to allow for peripheral biasing blocks to be placed within pixels. The 1024 pixels within a digital sub-chip array have a variety of full custom, semi-custom and automated timing driven functional blocks placed together. The methodology uses a modified mixed-mode on-top digital implementation flow to not only harness the tool efficiency for timing and floor-planning but also to maintain designer control over compact parasitically aware layout. The methodology uses the Cadence design platform, however it is not limited to this tool.

An experimental apparatus to simulate body-powered prosthetic usage: Development and preliminary evaluation.

PubMed

Gao, Fan; Rodriguez, Johanan; Kapp, Susan

2016-06-01

Harness fitting in the body-powered prosthesis remains more art than science due to a lack of consistent and quantitative evaluation. The aim of this study was to develop a mechanical, human-body-shaped apparatus to simulate body-powered upper limb prosthetic usage and evaluate its capability of quantitative examination of harness configuration. The apparatus was built upon a torso of a wooden mannequin and integrated major mechanical joints to simulate terminal device operation. Sensors were used to register cable tension, cable excursion, and grip force simultaneously. The apparatus allowed the scapula to move up to 127 mm laterally and the load cell can measure the cable tension up to 445 N. Our preliminary evaluation highlighted the needs and importance of investigating harness configurations in a systematic and controllable manner. The apparatus allows objective, systematic, and quantitative evaluation of effects of realistic harness configurations and will provide insightful and working knowledge on harness fitting in upper limb amputees using body-powered prosthesis. © The International Society for Prosthetics and Orthotics 2015.

Shoulder harnesses

DOT National Transportation Integrated Search

1979-06-01

This bibliography represents literature acquired since the establishment of the National Highway Traffic Safety Administration (NHTSA) concerning the development and use of shoulder harnesses in motor vehicles. It is comprised of NHTSA contract repor...

Left hepatectomy combined with hepatic artery resection for hilar cholangiocarcinoma: A retrospective cohort study.

PubMed

Peng, Chihan; Li, Chuan; Wen, Tianfu; Yan, Lvnan; Li, Bo

2016-08-01

To investigate the efficacy of our technique and policy on left hepatectomy (LH) with hepatic artery resection but without arterial reconstruction (HAR) in selected patients with hilar cholangiocarcinoma. From May 2005 to May 2012, 61 patients with hilar cholangiocarcinoma underwent left hepatectomy. These patients were divided into two groups: the LH with HAR group (n = 26) and the LH alone group (n = 35), based on whether hepatic artery resection was performed. We evaluated the serum total and direct bilirubin on postoperative day 7, length of hospital stay after surgery, postoperative complications, long-term postoperative survival and disease-free survival. The improvement in jaundice after surgery was comparable between the two groups (P = 0.837). There were no significant differences in the rates of postoperative complications or mortality between the LH with HAR group and the LH group (P = 0.654 and no assessment, respectively). The cumulative 1-, 2-, 3- and 5-year survival rates were 61.5%, 49%, 40.8% and 30.6% and 71.4%, 58.7%, 51.3% and 38.5%, respectively, in the LH with HAR group and the LH group (P = 0.383, including perioperative deaths). The cumulative 1-, 2-, 3- and 5-year disease-free survival rates were 61.9%, 41.6%, 29.7% and 14.8% and 58.2%, 50.7%, 44.3% and 23.6% in the LH with HAR group and the LH group, respectively (P = 0.695, including perioperative deaths). The postoperative complication rate was higher in patients with severe jaundice than those with non-severe jaundice, but no significant difference was detected (56.3% (9/16) vs. 46.7% (46.7%), P = 0.804). Similarly, 18.8% (3/16) postoperative mortality was found in patients with severe jaundice, compared to 4.4% (2/45) in those with non-severe jaundice. The difference was not significant (P = 0.139). For the cumulative 1-, 2-, 3- and 5-year survival and cumulative 1-, 2-, 3- and 5-year disease-free survival rates, patients with severe jaundice had poorer outcomes than those with non-severe jaundice (56.3%, 43.8%, 35% and 26.3% vs. 66.7%, 58.8%, 52.2% and 41.8%, P = 0.317; 50%, 42.9%, 35.7% and 13.4% vs. 63.8%, 54%, 35.6% and 21.3%, P = 0.753). Left hepatectomy combined with hepatic artery resection and no reconstruction for hilar cholangiocarcinoma is recommended when the following conditions are satisfied: 1) Bismuth-Corlette I, II, or IIIb hilar cholangiocarcinoma; 2) the tumor has infiltrated the hepatic artery with disappearance or markedly reduced arterial flow as detected by intraoperative ultrasound; 3) the color of the liver by visual observation does not change when the hepatic artery has been blocked for 5 min; and 4) removal of the tumor-infiltrated hepatic artery increases the probability of R0 resection for hilar cholangiocarcinoma. For obstructive jaundice from hilar cholangiocarcinoma, we recommend bile duct drainage before resection in patients with elevated preoperative serum TB. Copyright © 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

Cushion System for Multi-Use Child Safety Seat

NASA Technical Reports Server (NTRS)

Dabney, Richard W. (Inventor); Elrod, Susan V. (Inventor)

2007-01-01

A cushion system for use with a child safety seat has a plurality of bladders assembled to form a seat cushion that cooperates with the seat's safety harness. One or more sensors coupled to the safety harness sense tension therein and generate a signal indicative of the tension. Each of the bladders is individually pressurized by a pressurization system to define a support configuration of the seat cushion. The pressurization system is disabled when tension in the safety harness has attained a threshold level.

Cushion system for multi-use child safety seat

NASA Technical Reports Server (NTRS)

Elrod, Susan V. (Inventor); Dabney, Richard W. (Inventor)

2007-01-01

A cushion system for use with a child safety seat has a plurality of bladders assembled to form a seat cushion that cooperates with the seat's safety harness. One or more sensors coupled to the safety harness sense tension therein and generate a signal indicative of the tension. Each of the bladders is individually pressurized by a pressurization system to define a support configuration of the seat cushion. The pressurization system is disabled when tension in the safety harness has attained a threshold level.

Advanced air revitalization for optimized crew and plant environments

NASA Technical Reports Server (NTRS)

Lee, M. G.; Grigger, David J.; Brown, Mariann F.

1991-01-01

The Hybrid Air Revitalization System (HARS) closed ecosystem concept presented encompasses electrochemical CO2 and O2 separators, in conjunction with a mechanical condenser/separator for maintaining CO2, O2, and humidity levels in crew and plant habitats at optimal conditions. HARS requires no expendables, and allows flexible process control on the bases of electrochemical cell current, temperature, and airflow rate variations. HARS capacity can be easily increased through the incorporation of additional chemical cells. Detailed system flowcharts are provided.

Harnessing vision for computation.

PubMed

Changizi, Mark

2008-01-01

Might it be possible to harness the visual system to carry out artificial computations, somewhat akin to how DNA has been harnessed to carry out computation? I provide the beginnings of a research programme attempting to do this. In particular, new techniques are described for building 'visual circuits' (or 'visual software') using wire, NOT, OR, and AND gates in a visual 6modality such that our visual system acts as 'visual hardware' computing the circuit, and generating a resultant perception which is the output.

Improving highway advisory radio predictability and performance

DOT National Transportation Integrated Search

2011-01-01

Highway Advisory Radio (HAR) stations, sometimes referred to as Travelers Information Stations (TIS), : allow highway agencies to broadcast important messages about traffic, weather and roadway conditions to : motorists. Caltrans has deployed HAR ...

42 CFR 84.201 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of pressure over the entire area in contact with the face. (2) Facepieces for single-use vinyl... face. (b) Mouthpieces shall be equipped where applicable, with an adjustable and replaceable harness...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2010 CFR

2010-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2013 CFR

2013-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2014 CFR

2014-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2011 CFR

2011-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2012 CFR

2012-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

Human Activity Recognition Supported on Indoor Localization: A Systematic Review.

PubMed

Cerón, Jesús; López, Diego M

2018-01-01

The number of older adults is growing worldwide. This has a social and economic impact in all countries because of the increased number of older adults affected by chronic diseases, health emergencies, and disabilities, representing at the end high cost for the health system. To face this problem, the Ambient Assisted Living (AAL) domain has emerged. Its main objective is to extend the time that older adults can live independently in their homes. AAL is supported by different fields and technologies, being Human Activity Recognition (HAR), control of vital signs and location tracking the three of most interest during the last years. To perform a systematic review about Human Activity Recognition (HAR) approaches supported on Indoor Localization (IL) and vice versa, describing the methods they have used, the accuracy they have obtained and whether they have been directed towards the AAL domain or not. A systematic review of six databases was carried out (ACM, IEEE Xplore, PubMed, Science Direct and Springer). 27 papers were found. They were categorised into three groups according their approach: paper focus on 1. HAR, 2. IL, 3. HAR and IL. A detailed analysis of the following factors was performed: type of methods and technologies used for HAR, IL and data fusion, as well as the precision obtained for them. This systematic review shows that the relationship between HAR and IL has been very little studied, therefore providing insights of its potential mutual support to provide AAL solutions.

Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig.

PubMed

Moroni, Maria; Elliott, Thomas B; Deutz, Nicolaas E; Olsen, Cara H; Owens, Rossitsa; Christensen, Christine; Lombardini, Eric D; Whitnall, Mark H

2014-05-01

To characterize acute radiation syndrome (ARS) sequelae at doses intermediate between the bone marrow (H-ARS) and full gastrointestinal (GI-ARS) syndrome. Male minipigs, approximately 5 months old, 9-12 kg in weight, were irradiated with Cobalt-60 (total body, bilateral gamma irradiation, 0.6 Gy/min). Endpoints were 10-day survival, gastrointestinal histology, plasma citrulline, bacterial translocation, vomiting, diarrhea, vital signs, systemic inflammatory response syndrome (SIRS), febrile neutropenia (FN). We exposed animals to doses (2.2-5.0 Gy) above those causing H-ARS (1.6-2.0 Gy), and evaluated development of ARS. Compared to what was observed during H-ARS (historical data: Moroni et al. 2011a , 2011c ), doses above 2 Gy produced signs of increasingly severe pulmonary damage, faster deterioration of clinical conditions, and faster increases in levels of C-reactive protein (CRP). In the range of 4.6-5.0 Gy, animals died by day 9-10; signs of the classic GI syndrome, as measured by diarrhea, vomiting and bacterial translocation, did not occur. At doses above 2 Gy we observed transient reduction in circulating citrulline levels, and animals exhibited earlier depletion of blood elements and faster onset of SIRS and FN. An accelerated hematopoietic subsyndrome (AH-ARS) is observed at radiation doses between those producing H-ARS and GI-ARS. It is characterized by early onset of SIRS and FN, and greater lung damage, compared to H-ARS.

Feasibility study of a 270V dc flat cable aircraft electrical power distributed system

NASA Astrophysics Data System (ADS)

Musga, M. J.; Rinehart, R. J.

1982-01-01

This report documents the efforts of a one man-year feasibility study to evaluate the usage of flat conductors in place of conventional round wires for a 270 volt direct current aircraft power distribution system. This study consisted of designing electrically equivalent power distribution harnesses in flat conductor configurations for a currently operational military aircraft. Harness designs were established for installation in aircraft airframes which are: (1) All metal, or (2) All composite, or (3) a mixture of both. Flat cables have greater surface areas for heat transfer allowing higher current densities and therefore lighter weight conductors, than with round wires. Flat cables are less susceptible to electromagnetic effects. However, these positive factors are partially offset by installation and maintenance difficulties. This study concludes that the extent of these difficulties can be adequately limited with appropriate modification to present installation and maintenance practices. A comparative analysis of the flat and the round conductor power distribution harnesses was made for weight, cost, maintenance and reliability. The knowledge gained from the design and comparative analysis phases was used to generate design criteria for flat power cable harnesses and to identify and prioritize flat cable harness components and associated production tooling which require development.

Highway Advisory Radio Message Development Guide, Final Report

DOT National Transportation Integrated Search

1982-10-01

HIGHWAY ADVISORY RADIO (HAR) PROVIDES TRAFFIC OPERATING AGENCIES WITH THE CAPABILITY TO COMMUNICATE TRAFFIC AND TRAVEL RELATED INFORMATION TO MOTORISTS USING THE VEHICLE'S AM RADIO RECEIVER. THIS REPORT PRESENTS RECOMMENDED HAR MESSAGE DEVELOPMENT PR...

HARNESS END OF ELECTRIC TURBINE IN LOWER LEVEL OF HYDROELECTRIC ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HARNESS END OF ELECTRIC TURBINE IN LOWER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

42 CFR 84.151 - Harness test; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... concrete floor without disarranging the harness or exerting a pull on the facepiece. (5) The arrangement... manner that prevents a pull equivalent to dragging the maximum length of the hose over a concrete floor...

Versatile polyion complex micelles for peptide and siRNA vectorization to engineer tolerogenic dendritic cells.

PubMed

Mebarek, Naila; Vicente, Rita; Aubert-Pouëssel, Anne; Quentin, Julie; Mausset-Bonnefont, Anne-Laure; Devoisselle, Jean-Marie; Jorgensen, Christian; Bégu, Sylvie; Louis-Plence, Pascale

2015-05-01

Dendritic cells (DCs) are professional antigen-presenting cells that play a critical role in maintaining the balance between immunity and tolerance and, as such are a promising immunotherapy tool to induce immunity or to restore tolerance. The main challenge to harness the tolerogenic properties of DCs is to preserve their immature phenotype. We recently developed polyion complex micelles, formulated with double hydrophilic block copolymers of poly(methacrylic acid) and poly(ethylene oxide) blocks and able to entrap therapeutic molecules, which did not induce DC maturation. In the current study, the intrinsic destabilizing membrane properties of the polymers were used to optimize endosomal escape property of the micelles in order to propose various strategies to restore tolerance. On the first hand, we showed that high molecular weight (Mw) copolymer-based micelles were efficient to favor the release of the micelle-entrapped peptide into the endosomes, and thus to improve peptide presentation by immature (i) DCs. On the second hand, we put in evidence that low Mw copolymer-based micelles were able to favor the cytosolic release of micelle-entrapped small interfering RNAs, dampening the DCs immunogenicity. Therefore, we demonstrate the versatile use of polyionic complex micelles to preserve tolerogenic properties of DCs. Altogether, our results underscored the potential of such micelle-loaded iDCs as a therapeutic tool to restore tolerance in autoimmune diseases. Copyright © 2015 Elsevier B.V. All rights reserved.

Subject Load-Harness Interaction During Zero-Gravity Treadmill Exercise

NASA Technical Reports Server (NTRS)

McCrory, Jean L.; Baron, Heidi A.; Derr, Janice A.; Davis, Brian L.; Cavanagh, Peter R.

1996-01-01

When astronauts exercise on orbit, a subject load device (SLD) must be used to return the subject back to the supporting surface. The load in the SLD needs to be transferred the body by a harness which typically distributes this load between the pelvis and We shoulders. Through the use of a zero-gravity simulator, this research compared subject comfort and ground reaction forces during treadmill running at three levels of subject load (60%,80%, and 100% of body weight) in two harness designs ("shoulder only" and "waist "and shoulder ").

Flat conductor cable design, manufacture, and installation

NASA Technical Reports Server (NTRS)

Angele, W.; Hankins, J. D.

1973-01-01

Pertinent information for hardware selection, design, manufacture, and quality control necessary for flat conductor cable interconnecting harness application is presented. Comparisons are made between round wire cable and flat conductor cable. The flat conductor cable interconnecting harness systems show major cost, weight, and space savings, plus increased system performance and reliability. The design application section includes electrical characteristics, harness design and development, and a full treatise on EMC considerations. Manufacturing and quality control sections pertain primarily to the developed conductor-contact connector system and special flat conductor cable to round wire cable transitions.

Locomotion in simulated microgravity: gravity replacement loads

NASA Technical Reports Server (NTRS)

McCrory, Jean L.; Baron, Heidi A.; Balkin, Sandy; Cavanagh, Peter R.

2002-01-01

BACKGROUND: When an astronaut walks or runs on a treadmill in microgravity, a subject load device (SLD) is used to return him or her back to the treadmill belt. The gravity replacement load (GRL) in the SLD is transferred, via a harness, to the pelvis and/or the shoulders. This research compared comfort and ground reaction forces during treadmill running in a microgravity locomotion simulator at GRLs of 60%, 80%, and 100% of body weight (BW). Two harness designs (shoulder springs only (SSO) and waist and shoulder springs (WSS)) were used. HYPOTHESES: 1) The 100% BW gravity replacement load conditions would be comfortably tolerated and would result in larger ground reaction forces and loading rates than the lower load conditions, and 2) the WSS harness would be more comfortable than the SSO harness. METHODS: Using the Penn State Zero Gravity Locomotion Simulator (ZLS), 8 subjects ran at 2.0 m x s(-1) (4.5 mph) for 3 min at each GRL setting in each harness. Subjective ratings of harness comfort, ground reaction forces, and GRL data were collected during the final minute of exercise. RESULTS: The 100% BW loading conditions were comfortably tolerated (2.3 on a scale of 0-10), although discomfort increased as the GRL increased. There were no overall differences in perceived comfort between the two harnesses. The loading rates (27.1, 33.8, 39.1 BW x s(-1)) and the magnitudes of the first (1.0, 1.4, 1.6 BW) and second (1.3, 1.7, 1.9 BW) peaks of the ground reaction force increased with increasing levels (60, 80, 100% BW respectively) of GRL. CONCLUSIONS: Subjects were able to tolerate a GRL of 100% BW well. The magnitude of the ground reaction force peaks and the loading rate is directly related to the magnitude of the GRL.

Relative contributions of crust and mantle to generation of Campanian high-K calc-alkaline I-type granitoids in a subduction setting, with special reference to the Harşit Pluton, Eastern Turkey

NASA Astrophysics Data System (ADS)

Karsli, Orhan; Dokuz, Abdurrahman; Uysal, Ibrahim; Aydin, Faruk; Chen, Bin; Kandemir, Raif; Wijbrans, Jan

2010-10-01

We present elemental and Sr-Nd-Pb isotopic data for the magmatic suite (~79 Ma) of the Harşit pluton, from the Eastern Pontides (NE Turkey), with the aim of determining its magma source and geodynamic evolution. The pluton comprises granite, granodiorite, tonalite and minor diorite (SiO2 = 59.43-76.95 wt%), with only minor gabbroic diorite mafic microgranular enclaves in composition (SiO2 = 54.95-56.32 wt%), and exhibits low Mg# (<46). All samples show a high-K calc-alkaline differentiation trend and I-type features. The chondrite-normalized REE patterns are fractionated [(La/Yb) n = 2.40-12.44] and display weak Eu anomalies (Eu/Eu* = 0.30-0.76). The rocks are characterized by enrichment of LILE and depletion of HFSE. The Harşit host rocks have weak concave-upward REE patterns, suggesting that amphibole and garnet played a significant role in their generation during magma segregation. The host rocks and their enclaves are isotopically indistinguishable. Sr-Nd isotopic data for all of the samples display I Sr = 0.70676-0.70708, ɛ Nd(79 Ma) = -4.4 to -3.3, with T DM = 1.09-1.36 Ga. The lead isotopic ratios are (206Pb/204Pb) = 18.79-18.87, (207Pb/204Pb) = 15.59-15.61 and (208Pb/204Pb) = 38.71-38.83. These geochemical data rule out pure crustal-derived magma genesis in a post-collision extensional stage and suggest mixed-origin magma generation in a subduction setting. The melting that generated these high-K granitoidic rocks may have resulted from the upper Cretaceous subduction of the Izmir-Ankara-Erzincan oceanic slab beneath the Eurasian block in the region. The back-arc extensional events would have caused melting of the enriched subcontinental lithospheric mantle and formed mafic magma. The underplating of the lower crust by mafic magmas would have played a significant role in the generation of high-K magma. Thus, a thermal anomaly induced by underplated basic magma into a hot crust would have caused partial melting in the lower part of the crust. In this scenario, the lithospheric mantle-derived basaltic melt first mixed with granitic magma of crustal origin at depth. Then, the melts, which subsequently underwent a fractional crystallization and crustal assimilation processes, could ascend to shallower crustal levels to generate a variety of rock types ranging from diorite to granite. Sr-Nd isotope modeling shows that the generation of these magmas involved ~65-75% of the lower crustal-derived melt and ~25-35% of subcontinental lithospheric mantle. Further, geochemical data and the Ar-Ar plateau age on hornblende, combined with regional studies, imply that the Harşit pluton formed in a subduction setting and that the back-arc extensional period started by least ~79 Ma in the Eastern Pontides.

Zero-g simulation system for therapeutic application

NASA Technical Reports Server (NTRS)

Dane, D. H.

1971-01-01

System aids in therapeutic retraining of damaged muscles or functions as walking support during therapy. Articulated harness assembly contains patient, suspension system supports harness assembly in such a way as to counterbalance exertion of external forces on patient.

Summary of the CTS Transient Event Counter data after one year of operation. [Communication Technology Satellite

NASA Technical Reports Server (NTRS)

Stevens, N. J.; Klinect, V. W.; Gore, J. V.

1977-01-01

The environmental charging of satellite surfaces during geomagnetic substorms is the apparent cause of a significant number of anomalous events occurring on geosynchronous satellites since the early 1970's. Electromagnetic pulses produced in connection with the differential charging of insulators can couple into the spacecraft harness and cause electronic switching anomalies. An investigation conducted to determine the response of the spacecraft surfaces to substorm particle fluxes makes use of a harness transient detector. The harness transient detector, called the Transient Event Counter (TEC) was built and integrated into the Canadian-American Communications Technology Satellite (CTS). A description of the TEC and its operational characteristics is given and the obtained data are discussed. The data show that the satellite surfaces appear to be charged to the point that discharges occur and that the discharge-induced transients couple into the wire harnesses.

Design Process Improvement for Electric CAR Harness

NASA Astrophysics Data System (ADS)

Sawatdee, Thiwarat; Chutima, Parames

2017-06-01

In an automobile parts design company, the customer satisfaction is one of the most important factors for product design. Therefore, the company employs all means to focus its product design process based on the various requirements of customers resulting in high number of design changes. The objective of this research is to improve the design process of the electric car harness that effects the production scheduling by using Fault Tree Analysis (FTA) and Failure Mode and Effect Analysis (FMEA) as the main tools. FTA is employed for root cause analysis and FMEA is used to ranking a High Risk Priority Number (RPN) which is shows the priority of factors in the electric car harness that have high impact to the design of the electric car harness. After the implementation, the improvements are realized significantly since the number of design change is reduced from 0.26% to 0.08%.

Simulated weightlessness - Effects on bioenergetic balance

NASA Technical Reports Server (NTRS)

Jordan, J. P.; Sykes, H. A.; Crownover, J. C.; Schatte, C. L.; Simmons, J. B., II; Jordan, D. P.

1980-01-01

As a prelude to a flight experiment, an attempt was made to separate energy requirements associated with gravity from all other metabolic needs. The biological effects of weightlessness were simulated by suspending animals in a harness so that antigravity muscles were not supporting the body. Twelve pairs of rats were allowed to adapt to wearing a harness for 5 d. Experimental animals were then suspended in harness for 7 d followed by recovery for 7 d. Control animals were harnessed but never suspended. Oxygen consumption, carbon dioxide production and rate of (C-14)O2 expiration from radio-labeled glucose were monitored on selected days. Food intake and body mass were recorded daily. Metabolic rate decreased in experimental animals during 7 d of suspension and returned to normal during recovery. Although some of the metabolic changes may have related to variation in food intake, simulated weightlessness appears to directly affect bioenergetic balance.

Safety harness

DOEpatents

Gunter, Larry W.

1993-01-01

A safety harness to be worn by a worker, especially a worker wearing a plastic suit thereunder for protection in a radioactive or chemically hostile environment, which safety harness comprises a torso surrounding portion with at least one horizontal strap for adjustably securing the harness about the torso, two vertical shoulder straps with rings just forward of the of the peak of the shoulders for attaching a life-line and a pair of adjustable leg supporting straps releasibly attachable to the torso surrounding portion. In the event of a fall, the weight of the worker, when his fall is broken and he is suspended from the rings with his body angled slightly back and chest up, will be borne by the portion of the leg straps behind his buttocks rather than between his legs. Furthermore, the supporting straps do not restrict the air supplied through hoses into his suit when so suspended.

Preliminary report on the CTS transient event counter performance through the 1976 spring eclipse season

NASA Technical Reports Server (NTRS)

Stevens, N. J.; Levell, R. R.; Klinect, V. W.

1976-01-01

The transient event counter (TEC), senses and counts transients having a voltage rise of greater than five volts in three separate wire harnesses: the attitude control harness, the solar array instrumentation harness and the solar array power harness. The operational characteristics of TEC are defined and the preliminary results obtained through the first 90 days of operation including the spring 1976 eclipse season are presented. The results show that the Communications Technology Satellite was charged to the point where discharges occurred. The discharge induced transients did not cause any anomalous events in spacecraft operation. The data indicate that discharges can occur at any time during the day without preference to any local time quadrant. The number of discharges occurring in the one second sample interval are greater than anticipated. The compilation and review of the data is continuing.

Mobility of rare earth element in hydrothermal process and weathering product: a review

NASA Astrophysics Data System (ADS)

Lintjewas, L.; Setiawan, I.

2018-02-01

The Rare Earth Element (REE), consists of La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Lu, Ho, Er, Tm, Yb, are important elements to be used as raw materials of advanced technology such as semiconductors, magnets, and lasers. The research of REE in Indonesia has not been done. Several researches were conducted on granitic rocks and weathering product such as Bangka, Sibolga, West Kalimantan, West Sulawesi and Papua. REE can be formed by hydrothermal processes such as Bayan Obo, South China. The REE study on active hydrothermal system (geothermal) in this case also has the potential to produce mineral deposits. The purpose of this review paper is to know the mobility of REE on hydrothermal process and weathering products. Mobility of REE in the hydrothermal process can change the distribution patterns and REE content such as Ce, Eu, La, Lu, Nd, Sm, and Y. Another process besides the hydrothermal is weathering process. REE mobility is influenced by weathering products, where the REE will experience residual and secondary enrichment processes in heavier minerals.

Evaluation of a smartphone human activity recognition application with able-bodied and stroke participants.

PubMed

Capela, N A; Lemaire, E D; Baddour, N; Rudolf, M; Goljar, N; Burger, H

2016-01-20

Mobile health monitoring using wearable sensors is a growing area of interest. As the world's population ages and locomotor capabilities decrease, the ability to report on a person's mobility activities outside a hospital setting becomes a valuable tool for clinical decision-making and evaluating healthcare interventions. Smartphones are omnipresent in society and offer convenient and suitable sensors for mobility monitoring applications. To enhance our understanding of human activity recognition (HAR) system performance for able-bodied and populations with gait deviations, this research evaluated a custom smartphone-based HAR classifier on fifteen able-bodied participants and fifteen participants who suffered a stroke. Participants performed a consecutive series of mobility tasks and daily living activities while wearing a BlackBerry Z10 smartphone on their waist to collect accelerometer and gyroscope data. Five features were derived from the sensor data and used to classify participant activities (decision tree). Sensitivity, specificity and F-scores were calculated to evaluate HAR classifier performance. The classifier performed well for both populations when differentiating mobile from immobile states (F-score > 94 %). As activity recognition complexity increased, HAR system sensitivity and specificity decreased for the stroke population, particularly when using information derived from participant posture to make classification decisions. Human activity recognition using a smartphone based system can be accomplished for both able-bodied and stroke populations; however, an increase in activity classification complexity leads to a decrease in HAR performance with a stroke population. The study results can be used to guide smartphone HAR system development for populations with differing movement characteristics.

Earth Observations taken by the Expedition 13 crew

NASA Image and Video Library

2006-09-07

ISS013-E-78506 (7 Sept. 2006) --- Sand dunes near Mongolia's Har Lake are featured in this image photographed by an Expedition 13 crewmember on the International Space Station. Har (or Black) Lake is located in the western part of the country within the Valley of Lakes--part of a system of closed basins that stretches across central Asia. According to scientists, these basins are the remnants of larger paleolakes that had begun to shrink in size by approximately five thousand years ago as regional climate became drier. Today, the Valley of Lakes is an important ecological resource for study of steppe grasslands, and as resting points for large numbers of migratory birds. Portions of the basin are designated as national parks or other protected areas, and Har Lake itself is an ecotourism destination (usually by horseback). This oblique view captures the dynamic nature of the landscape of Har Lake. The lake is encircled by sand dune fields which encroach on the lower slopes of the Tobhata Mountains to the west and south. Gaps in the mountains have been exploited by sand dunes moving eastward (indicating westerly winds) -- the most striking example being a series of dunes entering Har Lake along its southwestern shoreline. Here, the dune forms reflect the channeling of winds through the break in the mountain ridgeline, leading to dune crests oriented transverse to northwesterly winds. Another well-developed line of dunes is visible between Har and Baga Lakes. While these dunes appear to cut across a lake surface, the dunes have in fact moved across a narrow stream channel.

Harnessing Energy from the Sun for Six Billion People

ScienceCinema

Nocera, Daniel

2018-05-24

Daniel Nocera, a Massachusetts Institute of Technology professor whose recent research focuses on solar-powered fuels, presents a Brookhaven Science Associates Distinguished Lecture, titled "Harnessing Energy from the Sun for Six Billion People -- One at a Time."

Harnessing Power from Tides: State of the Art.

ERIC Educational Resources Information Center

Ryan, Paul R.

1979-01-01

Discussed is the current, world-wide status of tidal energy as a potential power source. Potential sites and global tidal power prospects are identified. New engineering concepts relevant to the harnessing of tidal power are identified and described. (BT)

77 FR 21100 - Change in Bank Control Notices; Formations of, Acquisitions by, and Mergers of Bank Holding...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-09

... Nichols, Washington, DC; to acquire voting shares of HarVest Bancorp, Inc., Gaithersburg, Maryland, and thereby indirectly acquire voting shares of HarVest Bank of Maryland, Rockville, Maryland. Comments on...

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

PubMed Central

Li, Shu-Ping; Wang, Yu-Wen; Qi, Sheng-Lan; Zhang, Yun-Peng; Deng, Gang; Ding, Wen-Zheng; Ma, Chao; Lin, Qi-Yan; Guan, Hui-Da; Liu, Wei; Cheng, Xue-Mei; Wang, Chang-Hong

2018-01-01

The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity, antioxidant, anti-inflammatory, and many others, and have great potential for treating Alzheimer’s disease (AD). However, studies have showed that the two compounds have similar structures and in vitro AChE inhibitory activities but with significant difference in bioavailability. The objective of this study was to comparatively investigate the effects of HAL and HAR in memory deficits of scopolamine-induced mice. In the present study, mice were pretreated with HAL (2, 5, and 10 mg/kg), HAR (10, 20, and 30 mg/kg) and donepezil (5 mg/kg) by intragastrically for 7 days, and were daily intraperitoneal injected with scopolamine (1 mg/kg) to induce memory deficits and then subjected to behavioral evaluation by Morris water maze. To further elucidate the underlying mechanisms of HAL and HAR in improving learning and memory, the levels of various biochemical factors and protein expressions related to cholinergic function, oxidative stress, and inflammation were examined. The results showed that HAL and HAR could effectively ameliorate memory deficits in scopolamine-induced mice. Both of them exhibited an enhancement in cholinergic function by inhibiting AChE and inducing choline acetyltransferase (ChAT) activities, and antioxidant defense via increasing the antioxidant enzymes activities of superoxide dismutase and glutathione peroxidase, and reducing maleic diadehyde production, and anti-inflammatory effects through suppressing myeloperoxidase, tumor necrosis factor α, and nitric oxide as well as modulation of critical neurotransmitters such as acetylcholine (ACh), choline (Ch), L-tryptophan (L-Trp), 5-hydroxytryptamine (5-HT), γ-aminobutyric acid (γ-GABA), and L-glutamic acid (L-Glu). Furthermore, the regulations of HAL on cholinergic function, inflammation, and neurotransmitters were more striking than those of HAR, and HAL manifested a comparable antioxidant capacity to HAR. Remarkably, the effective dosage of HAL (2 mg/kg) was far lower than that of HAR (20 mg/kg), which probably due to the evidently differences in the bioavailability and metabolic stability of the two analogs. Taken together, all these results revealed that HAL may be a promising candidate compound with better anti-amnesic effects and pharmacokinetic characteristics for the treatments of AD and related diseases. PMID:29755345

NCCS Regression Test Harness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tharrington, Arnold N.

2015-09-09

The NCCS Regression Test Harness is a software package that provides a framework to perform regression and acceptance testing on NCCS High Performance Computers. The package is written in Python and has only the dependency of a Subversion repository to store the regression tests.

76 FR 6136 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... Beach, California; to acquire voting shares of HarVest BanCorp, Inc., Gaithersburg, Maryland, and thereby indirectly acquire voting shares of HarVest Bank of Maryland, Rockville, Maryland. Board of...

Evaluating the High Asia Reanalysis (HAR) using Gauge-based and Satellite Precipitation Data over High Mountain Asia

NASA Astrophysics Data System (ADS)

Pangaluru, K.; Velicogna, I.; Ciraci, E.; Mohajerani, Y.

2017-12-01

The Indus, Ganges and Brahmaputra (IGB) basins supply water for both domestic and agricultural demands, the latter of which is the mainstay of Indian economy. Here, we use high-resolution Asia Refined Analysis (HAR) rainfall datasets to study the spatial and temporal behavior of rainfall over the mountainous areas of the Indus, Ganges and Brahmaputra (IGB) over the period from 2001 to 2014. The validation of High Asia Refined Analysis (HAR) precipitation data is carried out with observational (GPCP, CRU and CPC) and satellite (TRMM_3B43) datasets for the period. We find that the relative differences between the HAR model and the satellite and gauge-based datasets varies between -9% and 67% for the seasonal mean and between 1% and 26% for the annual mean for all basins. The correlation between the HAR model and the observational datasets lies between 0.5 and 0.9 for all seasons. Spatial variations and monthly magnitudes of gridded precipitation trends are calculated by using the Mann-Kendall (MK) test and the Thei-Sen approach (TSA) respectively. We found significant positive trends precipitation grids over the IGB basins in the annual and monsoon season time frames, as opposed to winter and falls seasons.

Wireless Self-Acquistion of 12-Lead ECG via Android Smart Phone

NASA Technical Reports Server (NTRS)

Schlegel, Todd T.

2012-01-01

Researchers at NASA s Johnson Space Center and at Orbital Research, Inc. (a NASA SBIR grant recipient) have recently developed a dry-electrode harness that allows for self-acquisition of resting 12-lead ECGs by minimally trained laypersons. When used in conjunction with commercial wireless (e.g., Bluetooth(TM) or 802.11-enabled) 12-lead ECG devices and custom smart phone-based software, the collected 12-lead ECG data can also immediately be forwarded from any geographic location within cellular range to the user s physician(s) of choice. The system can also be used to immediately forward to central receiving stations 12-lead ECG data collected during space flight or during activities in any remote terrestrial location supported by an internet or cellular phone infrastructure. The main novel aspects of the system are first, the dry-electrode 12-lead ECG harness itself, and second, an accompanying Android(TM) smart phone-based wireless 12-lead ECG capability. The ECG harness nominally employs dry electrodes manufactured by Orbital Research, Inc, recently cleared through the Food and Drug Administration (FDA). However, other dry electrodes that are not yet FDA cleared, for example those recently developed by Nanosonic, Inc as part of another NASA SBIR grant, can also be used. The various advantageous features of the harness include: 1) laypersons can be quickly instructed on its correct use, remotely if necessary; 2) all tangled "leadwire spaghetti" is eliminated, as is the common clinical problem of "leadwire reversal"; 3) all adhesives and disposables are also eliminated, the harness being fully reusable; if multiple individuals intend to use use the same harness, then standard antimicrobial wipes can be employed to sterilize the dry electrodes (and harness surface if needed) between users; 5) padded cushions at the lateral sides of the torso function to press the left arm (LA) and right arm (RA) dry electrodes mounted on the cushions against sideward or downward-rested arms of the subject; 6) sufficient distal placement of the arm electrodes achieves good electrode abutment to the arms without the need for adhesives, straps, bands, bracelets, or gloves; 7) padding over the sternum avoids "tenting" in the V1 through V3 (and, when present, the V3R) electrode positions; 8) easy-to-don, one-piece design with an adjustable, front-side single point of connection and an adjustable shoulder strap; and 9) Lund or "modified Lund" placement of the dry electrodes, the results of which more effectively reproduce results from "standard" 12-lead ECG placements than do results from Mason-Likar placements. The main limitation of the harness is that "one size does not fit all", meaning that an appropriately sized harness (small, medium, large, etc) must be chosen on the basis of an individual's size. To facilitate the use of the harness with inexpensive, commodity-grade cell phones and tablet devices, 12-lead ECG software is also being developed to accompany the harness for wireless use with Android. For this part of the project, NASA has teamed with TopCoder, Inc and the Harvard-affiliated NASA Tournament Lab in sponsoring java-based software programming contests through TopCoder. While ECG signals from the harness can already be wirelessly received and thoroughly processed (locally or remotely) by commercial-grade conventional (as well as advanced) 12-lead ECG software running on Microsoft Windows(TM), the Android-based software, once completed, will "cast a wider net" by allowing for a greater percentage of cell phone owners to participate in inexpensive, store-and-forward recordings of 12-lead ECGs worldwide, including for example Android cell phone users in many remote, third-world locations. At the time of writing, the Android 12-lead ECG software platform consists of a basic but expanding graphical user interface and accompanying software that: 1) wirelessly receives the 12-lead ECG data stream from a Bluetooth-based, FDA-cleared 12-leaCG device attached to the harness; 2) locally stores the same data in binary format to the SD card on the Android cell phone; and 3) makes the data stream in available in real time, for now to TopCoder's java programming contestants.

Program for improved electrical harness documentation and fabrication

NASA Technical Reports Server (NTRS)

1971-01-01

Computer program provides automated print-out of harness interconnection table and automated cross-check of reciprocal pin/connector assignments, and improves accuracy and reliability of final documented data. Programs and corresponding library tapes are successfully and continuously employed on Nimbus spacecraft programs.

Manufacturing and quality control of interconnecting wire harnesses, Volume 2

NASA Technical Reports Server (NTRS)

1972-01-01

Interconnecting wire harnesses defined in the design standard are considered, including type 4, open bundle (not enclosed). Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into the document.

Motion performance and mooring system of a floating offshore wind turbine

NASA Astrophysics Data System (ADS)

Zhao, Jing; Zhang, Liang; Wu, Haitao

2012-09-01

The development of offshore wind farms was originally carried out in shallow water areas with fixed (seabed mounted) structures. However, countries with limited shallow water areas require innovative floating platforms to deploy wind turbines offshore in order to harness wind energy to generate electricity in deep seas. The performances of motion and mooring system dynamics are vital to designing a cost effective and durable floating platform. This paper describes a numerical model to simulate dynamic behavior of a new semi-submersible type floating offshore wind turbine (FOWT) system. The wind turbine was modeled as a wind block with a certain thrust coefficient, and the hydrodynamics and mooring system dynamics of the platform were calculated by SESAM software. The effect of change in environmental conditions on the dynamic response of the system under wave and wind loading was examined. The results indicate that the semi-submersible concept has excellent performance and SESAM could be an effective tool for floating wind turbine design and analysis.

Epigenetic Reprogramming of the Type III Interferon Response Potentiates Antiviral Activity and Suppresses Tumor Growth

PubMed Central

Ding, Siyuan; Khoury-Hanold, William; Iwasaki, Akiko; Robek, Michael D.

2014-01-01

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-specific antiviral immunity, the molecular mechanisms responsible for this confined receptor expression remain elusive. Here, we demonstrate that the histone deacetylase (HDAC) repression machinery mediates transcriptional silencing of the unique IFN-λ receptor subunit (IFNLR1) in a cell-type-specific manner. Importantly, HDAC inhibitors elevate receptor expression and restore sensitivity to IFN-λ in previously nonresponsive cells, thereby enhancing protection against viral pathogens. In addition, blocking HDAC activity renders nonresponsive cell types susceptible to the pro-apoptotic activity of IFN-λ, revealing the combination of HDAC inhibitors and IFN-λ to be a potential antitumor strategy. These results demonstrate that the type III IFN response may be therapeutically harnessed by epigenetic rewiring of the IFN-λ receptor expression program. PMID:24409098

Steps toward a globally available malaria vaccine: harnessing the potential of algae for future low cost vaccines.

PubMed

Jones, Carla S; Mayfield, Stephen P

2013-01-01

Malaria is an infectious disease that threatens half of the world's population. This debilitating disease is caused by infection from parasites of the genus Plasmodium. Insecticides, bed nets and drug therapies have lowered the prevalence and death rate associated with malaria but this disease continues to plague many populations around the world. In recent years, many organizations have suggested developing methods for a complete eradication of malaria. The most straightforward and effective method for this potential eradication will be through the development of a low-cost vaccine. To achieve eradication, it will be necessary to develop new vaccine candidates and novel systems for both the production and delivery of these vaccines. Recently, the green algae Chlamydomonas reinhardtii has been used for the recombinant expression of malaria vaccine candidates including the transmission blocking vaccine candidate Pfs48/45. Here, we discuss the potential of this research on the future development of a low-cost malaria vaccine candidate.

Microwave a.c. conductivity of domain walls in ferroelectric thin films

DOE PAGES

Tselev, Alexander; Yu, Pu; Cao, Ye; ...

2016-05-31

Ferroelectric domain walls are of great interest as elementary building blocks for future electronic devices due to their intrinsic few-nanometre width, multifunctional properties and field-controlled topology. To realize the electronic functions, domain walls are required to be electrically conducting and addressable non-destructively. However, these properties have been elusive because conducting walls have to be electrically charged, which makes them unstable and uncommon in ferroelectric materials. Here we reveal that spontaneous and recorded domain walls in thin films of lead zirconate and bismuth ferrite exhibit large conductance at microwave frequencies despite being insulating at d.c. We explain this effect by morphologicalmore » roughening of the walls and local charges induced by disorder with the overall charge neutrality. a.c. conduction is immune to large contact resistance enabling completely non-destructive walls read-out. Finally, this demonstrates a technological potential for harnessing a.c. conduction for oxide electronics and other materials with poor d.c. conduction, particularly at the nanoscale.« less

Microwave a.c. conductivity of domain walls in ferroelectric thin films

PubMed Central

Tselev, Alexander; Yu, Pu; Cao, Ye; Dedon, Liv R.; Martin, Lane W.; Kalinin, Sergei V.; Maksymovych, Petro

2016-01-01

Ferroelectric domain walls are of great interest as elementary building blocks for future electronic devices due to their intrinsic few-nanometre width, multifunctional properties and field-controlled topology. To realize the electronic functions, domain walls are required to be electrically conducting and addressable non-destructively. However, these properties have been elusive because conducting walls have to be electrically charged, which makes them unstable and uncommon in ferroelectric materials. Here we reveal that spontaneous and recorded domain walls in thin films of lead zirconate and bismuth ferrite exhibit large conductance at microwave frequencies despite being insulating at d.c. We explain this effect by morphological roughening of the walls and local charges induced by disorder with the overall charge neutrality. a.c. conduction is immune to large contact resistance enabling completely non-destructive walls read-out. This demonstrates a technological potential for harnessing a.c. conduction for oxide electronics and other materials with poor d.c. conduction, particularly at the nanoscale. PMID:27240997

Cerebral collaterals and collateral therapeutics for acute ischemic stroke.

PubMed

Winship, Ian R

2015-04-01

Cerebral collaterals are vascular redundancies in the cerebral circulation that can partially maintain blood flow to ischemic tissue when primary conduits are blocked. After occlusion of a cerebral artery, anastomoses connecting the distal segments of the MCA with distal branches of the ACA and PCA (known as leptomeningeal or pial collaterals) allow for partially maintained blood flow in the ischemic penumbra and delay or prevent cell death. However, collateral circulation varies dramatically between individuals, and collateral extent is significant predictor of stroke severity and recanalization rate. Collateral therapeutics attempt to harness these vascular redundancies by enhancing blood flow through pial collaterals to reduce ischemia and brain damage after cerebral arterial occlusion. While therapies to enhance collateral flow remain relatively nascent neuroprotective strategies, experimental therapies including inhaled NO, transient suprarenal aortic occlusion, and electrical stimulation of the parasympathetic sphenopalatine ganglion show promise as collateral therapeutics with the potential to improve treatment of acute ischemic stroke. © 2014 John Wiley & Sons Ltd.

Quality of harness fit for normal and low birthweight infants observed among newborns in infant car seats.

PubMed

Brown, Julie; Sinn, John Kam Hung; Chua, Aileen; Clarke, Elizabeth Clare

2017-04-01

Child restraint fit is important for crash protection. For newborns, standards universally require a rear-facing restraint and some upper limit on size, but historically there has been no specification of a lower design limit and there is concern over whether low birthweight infants (LBW) are adequately restrained. The aim of this study was to determine the quality of harness fit for newborns of low and normal weight in a range of modern child restraints. A convenience sample of infants (1.657-4.455 kg) were recruited from the postnatal ward and special care nursery <1 week from discharge. Infants (n=84) were assessed for harness fit in rear-facing-only restraints, convertible rear/forward restraints and a subset were assessed in a restraint specifically designed to accommodate LBW infants. Measures of harness fit were based on shoulder strap, crotch strap and buckle positioning. Less than 20% of infants achieved good harness fit, regardless of whether they were categorised as low (<2.5 kg) or normal weight. Rear-facing-only restraints were less likely to provide good fit than convertible restraints, in all measures of fit other than shoulder strap width. The proportions of infants achieving good fit were greater in the restraint designed for LBW infants than other restraint types. Poor accommodation continues to be a problem for LBW infants but is rectified in specifically designed restraints. Better specification of harness configuration for all rearward-facing restraints may be required to ensure adequate accommodation of normal birthweight infants. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Automatic recognition of falls in gait-slip training: Harness load cell based criteria.

PubMed

Yang, Feng; Pai, Yi-Chung

2011-08-11

Over-head-harness systems, equipped with load cell sensors, are essential to the participants' safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7m walkway. Each trial was monitored with a motion capture system, bilateral ground reaction force (GRF), harness force, and video recording. The fall trials were first unambiguously indentified with careful visual inspection of all video records. The recoveries without balance loss (in which subjects' trailing foot landed anteriorly to the slipping foot) were also first fully recognized from motion and GRF analyses. These analyses then set the gold standard for the outcome recognition with load cell measurements. Logistic regression analyses based on young subjects' data revealed that the peak load cell force was the best predictor of falls (with 100% accuracy) at the threshold of 30% body weight. On the other hand, the peak moving average force of load cell across 1s period, was the best predictor (with 100% accuracy) separating recoveries with backward balance loss (in which the recovery step landed posterior to slipping foot) from harness assistance at the threshold of 4.5% body weight. These threshold values were fully verified using the data from older adults (100% accuracy in recognizing falls). Because of the increasing popularity in the perturbation training coupling with the protective over-head-harness system, this new criterion could have far reaching implications in automatic outcome recognition during the movement therapy. Copyright © 2011 Elsevier Ltd. All rights reserved.

AUTOMATIC RECOGNITION OF FALLS IN GAIT-SLIP: A HARNESS LOAD CELL BASED CRITERION

PubMed Central

Yang, Feng; Pai, Yi-Chung

2012-01-01

Over-head-harness systems, equipped with load cell sensors, are essential to the participants’ safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7-m walkway. Each trial was monitored with a motion capture system, bilateral ground reaction force (GRF), harness force and video recording. The fall trials were first unambiguously indentified with careful visual inspection of all video records. The recoveries without balance loss (in which subjects’ trailing foot landed anteriorly to the slipping foot) were also first fully recognized from motion and GRF analyses. These analyses then set the gold standard for the outcome recognition with load cell measurements. Logistic regression analyses based on young subjects’ data revealed that peak load cell force was the best predictor of falls (with 100% accuracy) at the threshold of 30% body weight. On the other hand, the peak moving average force of load cell across 1-s period, was the best predictor (with 100% accuracy) separating recoveries with backward balance loss (in which the recovery step landed posterior to slipping foot) from harness assistance at the threshold of 4.5% body weight. These threshold values were fully verified using the data from older adults (100% accuracy in recognizing falls). Because of the increasing popularity in the perturbation training coupling with the protective over-head-harness system, this new criterion could have far reaching implications in automatic outcome recognition during the movement therapy. PMID:21696744

Post Hoc Analyses of Anxiety Measures in Adult Patients With Generalized Anxiety Disorder Treated With Vilazodone

PubMed Central

Khan, Arif; Durgam, Suresh; Tang, Xiongwen; Ruth, Adam; Mathews, Maju; Gommoll, Carl P.

2016-01-01

Objective To investigate vilazodone, currently approved for major depressive disorder in adults, for generalized anxiety disorder (GAD). Method Three randomized, double-blind, placebo-controlled studies showing positive results for vilazodone (2,040 mg/d) in adult patients with GAD (DSM-IV-TR) were pooled for analyses; data were collected from June 2012 to March 2014. Post hoc outcomes in the pooled intent-to-treat population (n = 1,462) included mean change from baseline to week 8 in Hamilton Anxiety Rating Scale (HARS) total score, psychic and somatic anxiety subscale scores, and individual item scores; HARS response (≥ 50% total score improvement) and remission (total score ≤ 7) at week 8; and category shifts, defined as HARS item score ≥ 2 at baseline (moderate to very severe symptoms) and score of 0 at week 8 (no symptoms). Results The least squares mean difference was statistically significant for vilazodone versus placebo in change from baseline to week 8 in HARS total score (−1.83, P < .0001) and in psychic anxiety (−1.21, P < .0001) and somatic anxiety (−0.63, P < .01) subscale scores; differences from placebo were significant on 11 of 14 HARS items (P < .05). Response rates were higher with vilazodone than placebo (48% vs 39%, P < .001), as were remission rates (27% vs 21%, P < .01). The percentage of patients who shifted to no symptoms was significant for vilazodone on several items: anxious mood, tension, intellectual, depressed mood, somatic-muscular, somatic-sensory, cardiovascular, respiratory, and autonomic symptoms (P < .05). Conclusions Treatment with vilazodone versus placebo was effective in adult GAD patients, with significant differences between treatment groups found on both psychic and somatic HARS items. Trial Registration ClinicalTrials.gov identifiers: NCT01629966, NCT01766401, NCT01844115. PMID:27486544

Post Hoc Analyses of Anxiety Measures in Adult Patients With Generalized Anxiety Disorder Treated With Vilazodone.

PubMed

Khan, Arif; Durgam, Suresh; Tang, Xiongwen; Ruth, Adam; Mathews, Maju; Gommoll, Carl P

2016-01-01

To investigate vilazodone, currently approved for major depressive disorder in adults, for generalized anxiety disorder (GAD). Three randomized, double-blind, placebo-controlled studies showing positive results for vilazodone (2,040 mg/d) in adult patients with GAD (DSM-IV-TR) were pooled for analyses; data were collected from June 2012 to March 2014. Post hoc outcomes in the pooled intent-to-treat population (n = 1,462) included mean change from baseline to week 8 in Hamilton Anxiety Rating Scale (HARS) total score, psychic and somatic anxiety subscale scores, and individual item scores; HARS response (≥ 50% total score improvement) and remission (total score ≤ 7) at week 8; and category shifts, defined as HARS item score ≥ 2 at baseline (moderate to very severe symptoms) and score of 0 at week 8 (no symptoms). The least squares mean difference was statistically significant for vilazodone versus placebo in change from baseline to week 8 in HARS total score (-1.83, P < .0001) and in psychic anxiety (-1.21, P < .0001) and somatic anxiety (-0.63, P < .01) subscale scores; differences from placebo were significant on 11 of 14 HARS items (P < .05). Response rates were higher with vilazodone than placebo (48% vs 39%, P < .001), as were remission rates (27% vs 21%, P < .01). The percentage of patients who shifted to no symptoms was significant for vilazodone on several items: anxious mood, tension, intellectual, depressed mood, somatic-muscular, somatic-sensory, cardiovascular, respiratory, and autonomic symptoms (P < .05). Treatment with vilazodone versus placebo was effective in adult GAD patients, with significant differences between treatment groups found on both psychic and somatic HARS items. ClinicalTrials.gov identifiers: NCT01629966, NCT01766401, NCT01844115.

42 CFR 84.173 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE... construction; minimum requirements. (a) Each respirator shall, where necessary, be equipped with a suitable...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

Harnessing Collaborative Annotations on Online Formative Assessments

ERIC Educational Resources Information Center

Lin, Jian-Wei; Lai, Yuan-Cheng

2013-01-01

This paper harnesses collaborative annotations by students as learning feedback on online formative assessments to improve the learning achievements of students. Through the developed Web platform, students can conduct formative assessments, collaboratively annotate, and review historical records in a convenient way, while teachers can generate…

Manufacture and quality control of interconnecting wire harnesses

NASA Technical Reports Server (NTRS)

1973-01-01

Four-volume series of documents has been prepared as standard reference. Each volume may be used separately and covers wire and cable preparation as well as harness fabrication and installation. Series should be useful addition to libraries of manufactures of electrical and electronic equipment.

SRB Altitude Switch Assembly Wire Harness Failure

NASA Technical Reports Server (NTRS)

Blanche, Jim

2002-01-01

This paper presents an assessment of two wire harness failures that had occurred in Solid Rocket Booster Altitude Switch Assemblies S/N 200001 and S/N 20002. A list of modifications to EDU #4 and modification of qualification units 2000001 and 2000002 are also presented.

High-aspect-ratio microstructures with versatile slanting angles on silicon by uniform metal-assisted chemical etching

NASA Astrophysics Data System (ADS)

Li, Liyi; Zhang, Cheng; Tuan, Chia-Chi; Chen, Yun; Wong, C.-P.

2018-05-01

High-aspect-ratio (HAR) microstructures on silicon (Si) play key roles in photonics and electromechanical devices. However, it has been challenging to fabricate HAR microstructures with slanting profiles. Here we report successful fabrication of uniform HAR microstructures with controllable slanting angles on (1 0 0)-Si by slanted uniform metal-assisted chemical etching (SUMaCE). The trenches have width of 2 µm, aspect ratio greater than 20:1 and high geometric uniformity. The slanting angles can be adjusted between 2-70° with respect to the Si surface normal. The results support a fundamental hypothesis that under the UMaCE condition, the preferred etching direction is along the normal of the thin film catalysts, regardless of the relative orientation of the catalyst to Si substrates or the crystalline orientation of the substrates. The SUMaCE method paves the way to HAR 3D microfabrication with arbitrary slanting profiles inside Si.

A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice

PubMed Central

Kamm, Gretel B.; López-Leal, Rodrigo; Lorenzo, Juan R.; Franchini, Lucía F.

2013-01-01

The developmental brain gene NPAS3 stands out as a hot spot in human evolution because it contains the largest number of human-specific, fast-evolving, conserved, non-coding elements. In this paper we studied 2xHAR142, one of these elements that is located in the fifth intron of NPAS3. Using transgenic mice, we show that the mouse and chimp 2xHAR142 orthologues behave as transcriptional enhancers driving expression of the reporter gene lacZ to a similar NPAS3 expression subdomain in the mouse central nervous system. Interestingly, the human 2xHAR142 orthologue drives lacZ expression to an extended expression pattern in the nervous system. Thus, molecular evolution of 2xHAR142 provides the first documented example of human-specific heterotopy in the forebrain promoted by a transcriptional enhancer and suggests that it may have contributed to assemble the unique properties of the human brain. PMID:24218632

Innovation in the Harnessing and Transfer of Technology: The Gran Mariscal de Ayacucho Foundation

ERIC Educational Resources Information Center

Lerner de Almea, Ruth

1977-01-01

Discusses the background, organization, success, problems, and functions of the Gran Mariscal de Ayacucho Foundation, Caracas, Venezuela, for producing human resources for the harnessing of scientific technology. The fellowship program supports study by students both at home and abroad. (SL)

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

Sea floor topography and backscatter intensity of the Historic Area Remediation Site (HARS), offshore of New York, based on multibeam surveys conducted in 1996, 1998, and 2000

USGS Publications Warehouse

Butman, Bradford; Danforth, W.W.; Knowles, S.C.; May, Brian; Serrett, Laurie

2000-01-01

An area offshore of Sandy Hook, New Jersey, has been used extensively for disposal of dredged and other materials, derived from the New York/New Jersey Harbor and surrounding areas, since the late 1800's (Figure 1). Between 1976 and 1995, the New York Bight Dredged Material Disposal Site, also known as the Mud Dump Site (Figure 2), received on average about 6 million cubic yards of material each year from federal and private maintenance dredging and from harbor deepening activities (Massa and others, 1996). In September 1997 the Mud Dump Site (MDS) was closed as an official ocean disposal site by the U.S. Environmental Protection Agency (http://www.epa.gov/), and the MDS and surrounding areas were designated as the Historic Area Remediation Site (HARS). The HARS is subdivided into a Primary Remediation Area (PRA, subdivided into 9 cells), a Buffer Zone, and a No-Discharge Zone (Figure 2). The sea floor of the HARS, approximately 9 square nautical miles in area, is being remediated by placing at least a one-meter cap of Category I (clean) dredged material on top of the existing surface sediments that exhibit varying degrees of degradation. (See http://www.nan.usace.army.mil/business/prjlinks/dmmp/benefic/hars.htm)(Category I sediments have no potential short or long-term impacts and are acceptable for unrestricted ocean disposal (EPA, 1996)). About 1.1 million cubic yards of dredged material for remediation was placed in the HARS in 1999, and 2.5 million cubic yards in 2000. Three multibeam echosounder surveys were carried out to map the topography and surficial geology of the HARS. The surveys were conducted November 23 - December 3, 1996, October 26 - November 11, 1998, and April 6 - 30, 2000. The surveys were carried out as part of a larger survey of the Hudson Shelf Valley and adjacent shelf (Butman and others, 1998, (http://pubs.usgs.gov/openfile/of98-616/). This report presents maps showing topography, shaded relief, and backscatter intensity (a measure of sea floor texture and roughness) at a scale of 1:25,000. Comparison of the topography and backscatter intensity from the three surveys show changes in topography and surficial sediment properties resulting from placement of dredged material in 1996 and 1997 prior to closure of the Mud Dump Site, as well as placement of capping material for remediation of the HARS. The surficial geology and sediments of the HARS and the surrounding region are described in Butman and others (1998), (http://pubs.usgs.gov/openfile/of98-616/, Schwab and others (1997, 2000, http://pubs.usgs.gov/openfile/of00-295/). A history of waste disposal in the New York Bight region is presented in Massa and others (1996).

Harnessing Technology to Support Learning

ERIC Educational Resources Information Center

Richardson, Tony; Ecclesfield, Nigel; Lewis, Christine

2008-01-01

In April 2008, one sees the start of the consultation on the second phase of the government's e-strategy for education, published in 2005 as "Harnessing technology: transforming learning and children's services." This follows hard on the heels of the progress report and implementation plan for the technology strategy for further…

The Belem Framework for Action: Harnessing the Power and Potential of Adult Learning and Education for a Viable Future

ERIC Educational Resources Information Center

Adult Learning, 2012

2012-01-01

This article presents the Belem Framework for Action. This framework focuses on harnessing the power and potential of adult learning and education for a viable future. This framework begins with a preamble on adult education and towards lifelong learning.

Manufacture and quality control of interconnecting wire harnesses, Volume 3

NASA Technical Reports Server (NTRS)

1972-01-01

The document covers interconnecting wire harnesses defined in the design standard, including type 6, enclosed in TFE heat shrink tubing; and type 7, flexible armored. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into this document.

Experimental impact protection with advanced restraint systems : preliminary primate with air bag and inertia reel/inverted-y yoke torso harness.

DOT National Transportation Integrated Search

1969-02-01

Both the inverted-Y yoke torso harness with inertia reel and the air- bag restraint system have had extensive independent development for some time by several engineering and research organizations for both aviation and ground vehicle occupant protec...

Harnessing Linguistic Variation to Improve Education. Rethinking Education. Volume 5

ERIC Educational Resources Information Center

Yiakoumetti, Androula, Ed.

2012-01-01

This volume brings together research carried out in a variety of geographic and linguistic contexts including Africa, Asia, Australia, Canada, the Caribbean, Europe and the United States and explores efforts to incorporate linguistic diversity into education and to "harness" this diversity for learners' benefit. It challenges the largely…

77 FR 11791 - Airworthiness Directives; Saab AB, Saab Aerosystems Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... installation wiring. For the reasons described above, this [EASA] AD requires a one- time [detailed] inspection... installation, and if corrosion is found repairing each affected harness braid or replacing each affected component and/or wiring harness. We are proposing this AD to detect and correct corrosion of critical system...

77 FR 29855 - Airworthiness Directives; Saab AB, Saab Aerosystems Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... electronic installation wiring. For the reasons described above, this [EASA] AD requires a one- time... corrosion of the electrical and electronics installation, and if corrosion is found repairing each affected harness braid or replacing each affected component and/or wiring harness. We are issuing this AD to detect...

Development of an intervention program to encourage shoulder harness use and aircraft retrofit in general aviation aircraft : phases I and II.

DOT National Transportation Integrated Search

1995-01-01

This report describes a study of shoulder harness installation and use rates in general aviation aircraft. Observations were made at six geographically separate areas to determine estimates of current installation and use rates. An expert panel was e...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

Harness the Power of Technology

ERIC Educational Resources Information Center

Duncan, Arne

2011-01-01

Today, U.S. educators are teaching in the midst of a technological revolution. Technology promises to provide innovative solutions in the nation's classrooms, just as it has transformed the way people communicate, socialize, and conduct business. In this article, the author argues that now is the time to harness technology to revolutionize the way…

Personalizing Learning through the Use of Technology

ERIC Educational Resources Information Center

Robinson, Carol; Sebba, Judy

2010-01-01

In March 2005, the Department for Education and Skills published its e-strategy, Harnessing Technology (DfES, 2005, Harnessing technology: Transforming Learning and Children's Services). Within this, two of its key objectives were: firstly to transform teaching and learning, and help to improve outcomes for children and young people, through…

Reliable Wiring Harness

NASA Technical Reports Server (NTRS)

Gaspar, Kenneth C.

1987-01-01

New harness for electrical wiring includes plugs that do not loosen from vibration. Ground braids prevented from detaching from connectors and constrained so braids do not open into swollen "birdcage" sections. Spring of stainless steel encircles ground braid. Self-locking connector contains ratchet not only preventing connector from opening, but tightens when vibrated.

Reliability in fiber optic cable harness manufacturing

NASA Astrophysics Data System (ADS)

McCoy, Bruce M.

Key aspects of manufacturing cable harnesses for aircraft and spacecraft that incorporate optical fiber/cables along with traditional wiring are discussed. Issues regarding feasibility of automation of assembly processes, manual assembly, testing, installation, quality assurance, reliability and maintainability are addressed. Training procedures, formal training programs, and their results are reviewed.

78 FR 28725 - Airworthiness Directives; Spectrolab Nightsun XP Searchlight

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... helicopter and remaining attached solely by the internal cable harness, or separating totally. This condition... Searchlight/ Gimbal could disconnect from the helicopter and remain attached solely by the internal cable harness or separate totally, resulting in damage to the helicopter or injury to persons on the ground...

77 FR 13993 - Airworthiness Directives; Spectrolab Nightsun XP Searchlight

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-08

.../Gimbal could disconnect from the helicopter and remain attached solely by the internal cable harness or... from the helicopter and remaining attached soley by the internal cable harness, or separating totally... incorporates two positive locking mechanisms: a torque value and safety wire applied to the nut. These locking...

African goat improvement project: A feed the future initiative harnessing geneticdiversity for conservation, disease resistance, and improved productivity

USDA-ARS?s Scientific Manuscript database

AFRICAN GOAT IMPROVEMENT PROJECT: A FEED THE FUTURE INITIATIVE HARNESSING GENETIC DIVERSITY FOR CONSERVATION, DISEASE RESISTANCE, AND IMPROVED PRODUCTIVITY Food production systems in Africa depend heavily on the use of locally adapted animals. These animals are of agricultural, cultural, and econom...

Parallel efficient rate control methods for JPEG 2000

NASA Astrophysics Data System (ADS)

Martínez-del-Amor, Miguel Á.; Bruns, Volker; Sparenberg, Heiko

2017-09-01

Since the introduction of JPEG 2000, several rate control methods have been proposed. Among them, post-compression rate-distortion optimization (PCRD-Opt) is the most widely used, and the one recommended by the standard. The approach followed by this method is to first compress the entire image split in code blocks, and subsequently, optimally truncate the set of generated bit streams according to the maximum target bit rate constraint. The literature proposes various strategies on how to estimate ahead of time where a block will get truncated in order to stop the execution prematurely and save time. However, none of them have been defined bearing in mind a parallel implementation. Today, multi-core and many-core architectures are becoming popular for JPEG 2000 codecs implementations. Therefore, in this paper, we analyze how some techniques for efficient rate control can be deployed in GPUs. In order to do that, the design of our GPU-based codec is extended, allowing stopping the process at a given point. This extension also harnesses a higher level of parallelism on the GPU, leading to up to 40% of speedup with 4K test material on a Titan X. In a second step, three selected rate control methods are adapted and implemented in our parallel encoder. A comparison is then carried out, and used to select the best candidate to be deployed in a GPU encoder, which gave an extra 40% of speedup in those situations where it was really employed.

Gesture’s role in speaking, learning, and creating language

PubMed Central

Goldin-Meadow, Susan; Alibali, Martha Wagner

2013-01-01

When speakers talk, they gesture. The goal of this chapter is to understand the contribution that these gestures make to how we communicate and think. Gesture can play a role in communication and thought at many timespans. We explore, in turn, gesture’s contribution to how language is produced and understood in the moment; its contribution to how we learn language and other cognitive skills; and its contribution to how language is created over generations, over childhood, and on-the-spot. We find that the gestures speakers produce when they talk are integral to communication and can be harnessed in a number of ways. (1) Gesture reflects speakers’ thoughts, often their unspoken thoughts, and thus can serve as a window onto cognition. Encouraging speakers to gesture can thus provide another route for teachers, clinicians, interviewers, etc., to better understand their communication partners. (2) Gesture can change speakers’ thoughts. Encouraging gesture thus has the potential to change how students, patients, witnesses, etc., think about a problem and, as a result, alter the course of learning, therapy, or an interchange. (3) Gesture provides building blocks that can be used to construct a language. By watching how children and adults who do not already have a language put those blocks together, we can observe the process of language creation first hand. Our hands are with us at all times and thus provide researchers and learners with an ever-present tool for understanding how we talk and think. PMID:22830562

Gesture's role in speaking, learning, and creating language.

PubMed

Goldin-Meadow, Susan; Alibali, Martha Wagner

2013-01-01

When speakers talk, they gesture. The goal of this review is to investigate the contribution that these gestures make to how we communicate and think. Gesture can play a role in communication and thought at many timespans. We explore, in turn, gesture's contribution to how language is produced and understood in the moment; its contribution to how we learn language and other cognitive skills; and its contribution to how language is created over generations, over childhood, and on the spot. We find that the gestures speakers produce when they talk are integral to communication and can be harnessed in a number of ways. (a) Gesture reflects speakers' thoughts, often their unspoken thoughts, and thus can serve as a window onto cognition. Encouraging speakers to gesture can thus provide another route for teachers, clinicians, interviewers, etc., to better understand their communication partners. (b) Gesture can change speakers' thoughts. Encouraging gesture thus has the potential to change how students, patients, witnesses, etc., think about a problem and, as a result, alter the course of learning, therapy, or an interchange. (c) Gesture provides building blocks that can be used to construct a language. By watching how children and adults who do not already have a language put those blocks together, we can observe the process of language creation. Our hands are with us at all times and thus provide researchers and learners with an ever-present tool for understanding how we talk and think.

Cooperative fault-tolerant distributed computing U.S. Department of Energy Grant DE-FG02-02ER25537 Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sunderam, Vaidy S.

2007-01-09

The Harness project has developed novel software frameworks for the execution of high-end simulations in a fault-tolerant manner on distributed resources. The H2O subsystem comprises the kernel of the Harness framework, and controls the key functions of resource management across multiple administrative domains, especially issues of access and allocation. It is based on a “pluggable” architecture that enables the aggregated use of distributed heterogeneous resources for high performance computing. The major contributions of the Harness II project result in significantly enhancing the overall computational productivity of high-end scientific applications by enabling robust, failure-resilient computations on cooperatively pooled resource collections.

Evaluation of Human and AutomationRobotics Integration Needs for Future Human Exploration Missions

NASA Technical Reports Server (NTRS)

Marquez, Jessica J.; Adelstein, Bernard D.; Ellis, Stephen; Chang, Mai Lee; Howard, Robert

2016-01-01

NASA employs Design Reference Missions (DRMs) to define potential architectures for future human exploration missions to deep space, the Moon, and Mars. While DRMs to these destinations share some components, each mission has different needs. This paper focuses on the human and automation/robotic integration needs for these future missions, evaluating them with respect to NASA research gaps in the area of space human factors engineering. The outcomes of our assessment is a human and automation/robotic (HAR) task list for each of the four DRMs that we reviewed (i.e., Deep Space Sortie, Lunar Visit/Habitation, Deep Space Habitation, and Planetary), a list of common critical HAR factors that drive HAR design.

DURIP: Electrokinetic Injection and Separation System for Analysis of Protein and Peptide Transport, Adsorption and Kinetics Instrumentation Proposal

DTIC Science & Technology

2015-03-18

both the electric double layer that forms at a solid-liquid interface as well as the biomolecules themselves, we can harness the coupled physics of...the biomolecules themselves, we can harness the coupled physics of complex biological fluids in nanofluidic channels towards unique, efficient

Compliant Walker

NASA Technical Reports Server (NTRS)

Kerley, James J.; Eklund, Wayne; Crane, Alan

1992-01-01

Walker supports person with limited use of legs and back. Enables person to stand upright, move with minimum load, and rest at will taking weight off legs. Consists of wheeled frame with body harness connected compliantly to side structures. Harness supports wearer upright when wearer relaxes and takes weight off lower extremities. Assumes partial to full body weight at user's discretion.

Harnessing ICT Potential: The Adoption and Analysis of ICT Systems for Enhancing the Student Learning Experience

ERIC Educational Resources Information Center

Dawson, Shane; Heathcote, Liz; Poole, Gary

2010-01-01

Purpose: This paper aims to examine how effective higher education institutions have been in harnessing the data capture mechanisms from their student information systems, learning management systems and communication tools for improving the student learning experience and informing practitioners of the achievement of specific learning outcomes.…

The Facebook-in-Action: Challenging, Harnessing and Enhancing Students Class Assignments and Projects

ERIC Educational Resources Information Center

Saifudin, Adam Mohd; Yacob, Aizan; Saad, Rohaizah

2016-01-01

Issues of universities students harnessing and capitalizing the usage of Facebook for their own learning capabilities and effective thinking is always the focus of education scholars, in assessing the quality class assignments and projects produced by them. Therefore, Facebook is now becoming unbearable influence since the internet activation in…

Using Discussion Methods to Inspire Diversity: Harnessing Social & Cultural Capital

ERIC Educational Resources Information Center

Raison, Brian; Gordon, Beverly

2012-01-01

How can you better harness the powerful social capital that exists within diverse individuals, families, businesses, and schools to make positive impacts in your community? What could you add to your next meeting--a Chamber strategic planning session, an employee wellness program, a non-profit board development--to better connect participants with…

14 CFR 91.313 - Restricted category civil aircraft: Operating limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

...-category civil airplane manufactured after July 18, 1978, unless an approved shoulder harness is installed for each front seat. The shoulder harness must be designed to protect each occupant from serious head injury when the occupant experiences the ultimate inertia forces specified in § 23.561(b)(2) of this...

14 CFR 91.313 - Restricted category civil aircraft: Operating limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

...-category civil airplane manufactured after July 18, 1978, unless an approved shoulder harness is installed for each front seat. The shoulder harness must be designed to protect each occupant from serious head injury when the occupant experiences the ultimate inertia forces specified in § 23.561(b)(2) of this...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 91.313 - Restricted category civil aircraft: Operating limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-category civil airplane manufactured after July 18, 1978, unless an approved shoulder harness is installed for each front seat. The shoulder harness must be designed to protect each occupant from serious head injury when the occupant experiences the ultimate inertia forces specified in § 23.561(b)(2) of this...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 91.313 - Restricted category civil aircraft: Operating limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

...-category civil airplane manufactured after July 18, 1978, unless an approved shoulder harness is installed for each front seat. The shoulder harness must be designed to protect each occupant from serious head injury when the occupant experiences the ultimate inertia forces specified in § 23.561(b)(2) of this...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 91.313 - Restricted category civil aircraft: Operating limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

...-category civil airplane manufactured after July 18, 1978, unless an approved shoulder harness is installed for each front seat. The shoulder harness must be designed to protect each occupant from serious head injury when the occupant experiences the ultimate inertia forces specified in § 23.561(b)(2) of this...

Harnessing the Power of Interactivity for Instruction.

ERIC Educational Resources Information Center

Borsook, Terry K.

Arguing that what sets the computer apart from all other teaching devices is its potential for interactivity, this paper examines the concept of interactivity and explores ways in which its power can be harnessed and put to work. A discussion of interactivity in human-to-human communication sets a context within which to view human/computer…

14 CFR 91.105 - Flight crewmembers at stations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... crewmember of a U.S.-registered civil aircraft shall, during takeoff and landing, keep his or her shoulder... at the crewmember's station is not equipped with a shoulder harness; or (2) The crewmember would be unable to perform required duties with the shoulder harness fastened. [Doc. No. 18334, 54 FR 34294, Aug...

14 CFR 91.105 - Flight crewmembers at stations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... crewmember of a U.S.-registered civil aircraft shall, during takeoff and landing, keep his or her shoulder... at the crewmember's station is not equipped with a shoulder harness; or (2) The crewmember would be unable to perform required duties with the shoulder harness fastened. [Doc. No. 18334, 54 FR 34294, Aug...

77 FR 33125 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... along the wing leading edge and the inboard end rib of the wing leading edge due to insufficient clearance. This proposed AD would require inspecting the wire harness along the leading edge for chafing... to detect and correct chafing damage to the wire harness along the wing leading edge which, if not...

Harnessing the power of big data: infusing the scientific method with machine learning to transform ecology

USDA-ARS?s Scientific Manuscript database

Most efforts to harness the power of big data for ecology and environmental sciences focus on data and metadata sharing, standardization, and accuracy. However, many scientists have not accepted the data deluge as an integral part of their research because the current scientific method is not scalab...

Accelerations and Passenger Harness Loads Measured in Full-Scale Light-Airplane Crashes

NASA Technical Reports Server (NTRS)

Eiband, A. Martin; Simpkinson, Scott H.; Black, Dugald O.

1953-01-01

Full-scale light-airplane crashes simulating stall-spin accidents were conducted to determine the decelerations to which occupants are exposed and the resulting harness forces encountered in this type of accident. Crashes at impact speeds from 42 to 60 miles per hour were studied. The airplanes used were of the familiar steel-tube, fabric-covered, tandem, two-seat type. In crashes up to an impact speed of 60 miles per hour, crumpling of the forward fuselage structure prevented the maximum deceleration at the rear-seat location from exceeding 26 to 33g. This maximum g value appeared independent of the impact speed. Restraining forces in the seatbelt - shoulder-harness combination reached 5800 pounds. The rear-seat occupant can survive crashes of the type studied at impact speeds up to 60 miles per hour, if body movement is restrained by an adequate seatbelt-shoulder-harness combination so as to prevent injurious contact with obstacles normally present in the cabin. Inwardly collapsing cabin structure, however, is a potential hazard in the higher-speed crashes.

Effects of Caudal Elevation on Testicular Function in Rats: Separation of Effects on Spermatogenesis and Steroidogenesis

NASA Technical Reports Server (NTRS)

Deaver, D. R.; Amann, R. P.; Hammerstedt, R. H.; Ball, R.; Veeramachaneni, D. N. R.; Musacchia, X. J.

1992-01-01

A variety of biologic processes are perturbed when exposed to microgravity (space flight) for more than 7 days, including testicular function. Suspension of rats in a special harness (caudal elevation) to induce thoracic pooling of blood fluids and remove the support function of the hind limbs is used to mimic, on earth, the effects of microgravity encountered during space flight. Typically, this induces cryptorchidism in male rats. Three experiments were conducted to differentiate the effects of caudal elevation (30 deg angle) and anatomic location of testes on spermatogenesis and steroidogenesis. Rats were subjected to caudal elevation for 7 days using either a tail harness or a whole-body harness. Testes of rats fell into the abdominal cavity when a tail harness was used, but ligation of the iguinal canal prevented this repositioning. For rats with abdominal testes, testicular weight was reduced (P less than 0.05) and histology of testes was abnormal; the number of spermatids per gram parenchyma was lower (P less than 0.05) in tail-suspended rats compared with control rats.

Many human accelerated regions are developmental enhancers

PubMed Central

Capra, John A.; Erwin, Genevieve D.; McKinsey, Gabriel; Rubenstein, John L. R.; Pollard, Katherine S.

2013-01-01

The genetic changes underlying the dramatic differences in form and function between humans and other primates are largely unknown, although it is clear that gene regulatory changes play an important role. To identify regulatory sequences with potentially human-specific functions, we and others used comparative genomics to find non-coding regions conserved across mammals that have acquired many sequence changes in humans since divergence from chimpanzees. These regions are good candidates for performing human-specific regulatory functions. Here, we analysed the DNA sequence, evolutionary history, histone modifications, chromatin state and transcription factor (TF) binding sites of a combined set of 2649 non-coding human accelerated regions (ncHARs) and predicted that at least 30% of them function as developmental enhancers. We prioritized the predicted ncHAR enhancers using analysis of TF binding site gain and loss, along with the functional annotations and expression patterns of nearby genes. We then tested both the human and chimpanzee sequence for 29 ncHARs in transgenic mice, and found 24 novel developmental enhancers active in both species, 17 of which had very consistent patterns of activity in specific embryonic tissues. Of these ncHAR enhancers, five drove expression patterns suggestive of different activity for the human and chimpanzee sequence at embryonic day 11.5. The changes to human non-coding DNA in these ncHAR enhancers may modify the complex patterns of gene expression necessary for proper development in a human-specific manner and are thus promising candidates for understanding the genetic basis of human-specific biology. PMID:24218637

Hepatic Artery Resection for Bismuth Type III and IV Hilar Cholangiocarcinoma: Is Reconstruction Always Required?

PubMed

Hu, Hai-Jie; Jin, Yan-Wen; Zhou, Rong-Xing; Shrestha, Anuj; Ma, Wen-Jie; Yang, Qin; Wang, Jun-Ke; Liu, Fei; Cheng, Nan-Sheng; Li, Fu-Yu

2018-03-06

The objective of the study is to examine the feasibility of hepatic artery resection (HAR) without subsequent reconstruction (RCS) in specified patients of Bismuth type III and IV hilar cholangiocarcinoma. We retrospectively reviewed 63 patients who underwent hepatic artery resection for Bismuth type III and IV hilar cholangiocarcinoma. These patients were subsequently enrolled into two groups based on whether the artery reconstruction was conducted. Postoperative morbidity and mortality, and long-term survival outcome were compared between the two groups. There were 29 patients in HAR group and 34 patients in the HAR + RCS group. Patients with hepatic artery reconstruction tended to have longer operative time (545.6 ± 143.1 min vs. 656.3 ± 192.8 min; P = 0.013) and smaller tumor size (3.0 ± 1.1 cm vs. 2.5 ± 0.9 cm; P = 0.036). The R0 resection margin was comparable between the HAR group and HAR + RCS group (86.2 vs. 85.3%; P > 0.05). Twelve patients (41.4%) with 24 complications in HAR group and 13 patients (38.2%) with 25 complications in HAR + RCS group were recorded (P = 0.799). The postoperative hepatic failure rate (13.8 vs. 5.9%) and postoperative mortality rate (3.4% vs. 2.9%) were also comparable between the two groups. In the HAR group, the overall 1-, 3-, and 5-year survival rates were 72, 41, and 19%, respectively; while in the HAR + RCS group, the overall 1-, 3-, and 5-year survival rates were 79, 45, and 25%, respectively (P = 0.928). Hepatic artery resection without reconstruction is also a safe and feasible surgical procedure for highly selected cases of Bismuth type III and IV hilar cholangiocarcinoma.

High Speed Link Radiated Emission Reduction

NASA Astrophysics Data System (ADS)

Bisognin, P.; Pelissou, P.; Cissou, R.; Giniaux, M.; Vargas, O.

2016-05-01

To control the radiated emission of high-speed link and associated unit, the current approach is to implement overall harness shielding on cables bundles. This method is very efficient in the HF/ VHF (high frequency/ very high frequency) and UHF (ultra-high frequency) ranges when the overall harness shielding is properly bonded on EMC back-shell. Unfortunately, with the increasing frequency, the associated half wavelength matches with the size of Sub-D connector that is the case for the L band. Therefore, the unit connectors become the main source of interference emission. For the L-band and S-band, the current technology of EMC back-shell leaves thin aperture matched with the L band half wavelength and therefore, the shielding effectiveness is drastically reduced. In addition, overall harness shielding means significant increases of the harness mass.Airbus D&S Toulouse and Elancourt investigated a new solution to avoid the need of overall harness shielding. The objective is to procure EM (Electro-Magnetic) clean unit connected to cables bundles free of any overall harness shielding. The proposed solution is to implement EMC common mode filtering on signal interfaces directly on unit PCB as close as possible the unit connector.Airbus D&S Elancourt designed and manufactured eight mock-ups of LVDS (Low Voltage Differential Signaling) interface PCBs' with different solutions of filtering. After verification of the signal integrity, three mock-ups were retained (RC filter and two common mode choke coil) in addition to the reference one (without EMC filter).Airbus D&S Toulouse manufactured associated LVDS cable bundles and integrated the RX (Receiver) and TX (Transmitter) LVDS boards in shielded boxes.Then Airbus D&S performed radiated emission measurement of the LVDS links subassemblies (e.g. RX and TX boxes linked by LVDS cables) according to the standard test method. This paper presents the different tested solutions and main conclusions on the feasibility of such approach.

An Active Heater Control Concept to Meet IXO Type Mirror Module Thermal-Structural Distortion Requirement

NASA Technical Reports Server (NTRS)

Choi, Michael

2013-01-01

Flight mirror assemblies (FMAs) of large telescopes, such as the International X-ray Observatory (IXO), have very stringent thermal-structural distortion requirements. The spatial temperature gradient requirement within a FMA could be as small as 0.05 C. Con ventionally, heaters and thermistors are attached to the stray light baffle (SLB), and centralized heater controllers (i.e., heater controller boards located in a large electronics box) are used. Due to the large number of heater harnesses, accommodating and routing them is extremely difficult. The total harness length/mass is very large. This innovation uses a thermally conductive pre-collimator to accommodate heaters and a distributed heater controller approach. It minimizes the harness length and mass, and reduces the problem of routing and accommodating them. Heaters and thermistors are attached to a short (4.67 cm) aluminum portion of the pre-collimator, which is thermally coupled to the SLB. Heaters, which have a very small heater power density, and thermistors are attached to the exterior of all the mirror module walls. The major portion (23.4 cm) of the pre-collimator for the middle and outer modules is made of thin, non-conductive material. It minimizes the view factors from the FMA and heated portion of the precollimator to space. It also minimizes heat conduction from one end of the FMA to the other. Small and multi-channel heater controllers, which have adjustable set points and internal redundancy, are used. They are mounted to the mechanical support structure members adjacent to each module. The IXO FMA, which is 3.3 m in diameter, is an example of a large telescope. If the heater controller boards are centralized, routing and accommodating heater harnesses is extremely difficult. This innovation has the following advantages. It minimizes the length/mass of the heater harness between the heater controllers and heater circuits. It reduces the problem of routing and accommodating the harness on the FMA. It reduces the risk of X-ray attenuation caused by the heater harness. Its adjustable set point capability eliminates the need for survival heater circuits. The operating mode heater circuits can also be used as survival heater circuits. In the non-operating mode, a lower set point is used.

Application of the hybrid ANFIS models for long term wind power density prediction with extrapolation capability.

PubMed

Hossain, Monowar; Mekhilef, Saad; Afifi, Firdaus; Halabi, Laith M; Olatomiwa, Lanre; Seyedmahmoudian, Mehdi; Horan, Ben; Stojcevski, Alex

2018-01-01

In this paper, the suitability and performance of ANFIS (adaptive neuro-fuzzy inference system), ANFIS-PSO (particle swarm optimization), ANFIS-GA (genetic algorithm) and ANFIS-DE (differential evolution) has been investigated for the prediction of monthly and weekly wind power density (WPD) of four different locations named Mersing, Kuala Terengganu, Pulau Langkawi and Bayan Lepas all in Malaysia. For this aim, standalone ANFIS, ANFIS-PSO, ANFIS-GA and ANFIS-DE prediction algorithm are developed in MATLAB platform. The performance of the proposed hybrid ANFIS models is determined by computing different statistical parameters such as mean absolute bias error (MABE), mean absolute percentage error (MAPE), root mean square error (RMSE) and coefficient of determination (R2). The results obtained from ANFIS-PSO and ANFIS-GA enjoy higher performance and accuracy than other models, and they can be suggested for practical application to predict monthly and weekly mean wind power density. Besides, the capability of the proposed hybrid ANFIS models is examined to predict the wind data for the locations where measured wind data are not available, and the results are compared with the measured wind data from nearby stations.

Application of the hybrid ANFIS models for long term wind power density prediction with extrapolation capability

PubMed Central

Mekhilef, Saad; Afifi, Firdaus; Halabi, Laith M.; Olatomiwa, Lanre; Seyedmahmoudian, Mehdi; Stojcevski, Alex

2018-01-01

In this paper, the suitability and performance of ANFIS (adaptive neuro-fuzzy inference system), ANFIS-PSO (particle swarm optimization), ANFIS-GA (genetic algorithm) and ANFIS-DE (differential evolution) has been investigated for the prediction of monthly and weekly wind power density (WPD) of four different locations named Mersing, Kuala Terengganu, Pulau Langkawi and Bayan Lepas all in Malaysia. For this aim, standalone ANFIS, ANFIS-PSO, ANFIS-GA and ANFIS-DE prediction algorithm are developed in MATLAB platform. The performance of the proposed hybrid ANFIS models is determined by computing different statistical parameters such as mean absolute bias error (MABE), mean absolute percentage error (MAPE), root mean square error (RMSE) and coefficient of determination (R2). The results obtained from ANFIS-PSO and ANFIS-GA enjoy higher performance and accuracy than other models, and they can be suggested for practical application to predict monthly and weekly mean wind power density. Besides, the capability of the proposed hybrid ANFIS models is examined to predict the wind data for the locations where measured wind data are not available, and the results are compared with the measured wind data from nearby stations. PMID:29702645

Harnessing Technology for Promoting Undergraduate Art Education: A Novel Model That Streamlines Learning between Classroom, Museum, and Home

ERIC Educational Resources Information Center

Kali, Yael; Sagy, Ornit; Kuflik, Tsvi; Mogilevsky, Orit; Maayan-Fanar, Emma

2015-01-01

We report on the development and evaluation of an innovative instructional model, which harnesses advanced technologies and local resources (an in-campus museum), to support undergraduate-level art history students in developing the skills required for analyzing artwork. Theory suggests that analyzing artwork requires theoretical knowledge and…

Improving Students' Educational Experience by Harnessing Digital Technology: elgg in the ODL Environment

ERIC Educational Resources Information Center

Tung, Lai Cheng

2013-01-01

Given the rising popularity of both open and distance learning (ODL) and social networking tools, it seems logical to merge and harness these two popular technologies with the goal of improving student educational experience. The integration seems to hold tremendous promise for the open and distance learning mode. To reduce the gap in the…

14 CFR 29.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... serious injury in an emergency landing as a result of the inertial factors specified in § 29.561(b) and dynamic conditions specified in § 29.562. (b) Each occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious...

14 CFR 29.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... serious injury in an emergency landing as a result of the inertial factors specified in § 29.561(b) and dynamic conditions specified in § 29.562. (b) Each occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious...

14 CFR 29.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... serious injury in an emergency landing as a result of the inertial factors specified in § 29.561(b) and dynamic conditions specified in § 29.562. (b) Each occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious...

14 CFR 29.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... serious injury in an emergency landing as a result of the inertial factors specified in § 29.561(b) and dynamic conditions specified in § 29.562. (b) Each occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious...

78 FR 71028 - Combi USA, Inc., Denial of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... based on its own dynamic testing of the Coccoro and Zeus 360 child restraint systems. According to Combi... under any circumstances, as the forces acting on the harness system in dynamic testing are less than 22... on the harness system when subjected to FMVSS No. 213 and NCAP crash pulse dynamic testing, the...

Registration of a male fertility restorer oilseed sunflower germplasm HA-R9 resistant to sunflower rust

USDA-ARS?s Scientific Manuscript database

The sunflower (Helianthus annuus L.) germplasm HA-R9 (Reg. No.xxx, PI 667595) was developed by the USDA-ARS, Sunflower and Plant Biology Research Unit in collaboration with the Agricultural Experiment Station of North Dakota State University and released in January, 2013. Sunflower rust (caused by P...

Nylon shock absorber prevents injury to parachute jumpers

NASA Technical Reports Server (NTRS)

Mandel, J. A.

1966-01-01

Nylon shock absorbers reduce the canopy-opening shock of a parachute to a level that protects the wearer from injury. A shock absorber is mounted on each of the four risers between the shroud lines and the harness. Because of their size and location, they pose no problem in repacking the chute and harness after a jump.

Hopkins installs wire harnesses

NASA Image and Video Library

2013-11-24

ISS038-E-008291 (24 Nov. 2013) --- NASA astronaut Michael Hopkins, Expedition 38 flight engineer, installs wire harnesses in the International Space Station?s Harmony node to support the installation of Ethernet video cables for the station?s local area network. These new cables will provide Ethernet connectivity to the visiting vehicles that dock to Harmony?s Earth-facing port.

Thermal and Electrical Conductivity Measurements of Cda 510 Phosphor Bronze

NASA Astrophysics Data System (ADS)

Tuttle, J.; Canavan, E.; DiPirro, M.

2010-04-01

Many cryogenic systems use electrical cables containing phosphor bronze wire. While phosphor bronze's electrical and thermal conductivity values have been published, results vary among different phosphor bronze formulations. The James Webb Space Telescope (JWST) will use several phosphor bronze wire harnesses containing a specific formulation (CDA 510, annealed temper). These harnesses dominate the heat conducted into the JWST instrument stage, and approximately half of the harness conductance is due to the phosphor bronze wires. Since the JWST radiators are expected to keep the instruments at their operating temperature with limited cooling margin, it is important to know the thermal conductivity of the actual alloy being used. We describe an experiment that measured its electrical and thermal conductivity between 4 and 295 Kelvin.

GENERATION OF TWO NOVEL CELL LINES THAT STABLY EXPRESS HAR AND FIREFLY LUCIFERASE GENES FOR ENDOCRINE SCREENING

EPA Science Inventory

Generation of Two Novel Cell Lines that Stably Express hAR and Firefly Luciferase Genes for Endocrine Screening
K.L. Bobseine*1, W.R. Kelce2, P.C. Hartig*1, and L.E. Gray, Jr.1
1USEPA, NHEERL, Reproductive Toxicology Division, RTP, NC, 2Searle, Reproductive Toxicology Divi...

Transformation of Participation and Learning: Three Case Studies of Young Learners Harnessing Mobile Technologies for Seamless Science Learning

ERIC Educational Resources Information Center

Toh, Yancy; So, Hyo-Jeong; Seow, Peter; Chen, Wenli

2017-01-01

The main goal of this research is to understand how young children use mobile technology such as smartphones to traverse different learning contexts and harness a constellation of resources to make sense of their science learning in daily lives. We adopted Rogoff's sociocultural lens of transformation of participation that helps us understand how…

Harnessing the crowd to accelerate molecular medicine research.

PubMed

Smith, Robert J; Merchant, Raina M

2015-07-01

Crowdsourcing presents a novel approach to solving complex problems within molecular medicine. By leveraging the expertise of fellow scientists across the globe, broadcasting to and engaging the public for idea generation, harnessing a scalable workforce for quick data management, and fundraising for research endeavors, crowdsourcing creates novel opportunities for accelerating scientific progress. Copyright © 2015 Elsevier Ltd. All rights reserved.

Harnessing Sparse and Low-Dimensional Structures for Robust Clustering of Imagery Data

ERIC Educational Resources Information Center

Rao, Shankar Ramamohan

2009-01-01

We propose a robust framework for clustering data. In practice, data obtained from real measurement devices can be incomplete, corrupted by gross errors, or not correspond to any assumed model. We show that, by properly harnessing the intrinsic low-dimensional structure of the data, these kinds of practical problems can be dealt with in a uniform…

Harnessing the Potential of ICTs: Literacy and Numeracy Programmes Using Radio, TV, Mobile Phones, Tablets and Computers. 2nd Edition

ERIC Educational Resources Information Center

Hanemann, Ulrike, Ed.; Scarpino, Cassandra, Ed.

2016-01-01

The UNESCO Institute for Lifelong Learning (UIL) has published a second edition of "Harnessing the Potential of ICTs: Literacy and Numeracy Programmes Using Radio, TV, Mobile Phones, Tablets and Computers." This compilation of case studies from all world regions presents promising literacy and numeracy programmes that use information and…

CJ concept for advanced aircraft wiring

NASA Technical Reports Server (NTRS)

Redslob, J.

1972-01-01

The techniques and hardware are described which were developed for facilitating the use of flexible flat conductor cable (FFCC) in commercial air transports. The system was designed as an evolutionary transition from the current round wire harnessing to the use of FFCC harnesses. The equipment discussed includes the pressure crimp barrel designed for terminating FFCC, reel-fed applicator, cable connectors and adaptors, and equipment racks.

76 FR 62656 - Airworthiness Directives; Saab AB, Saab Aerosystems Model 340A (SAAB/SF340A) and SAAB 340B Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... MLG's separation bolt harness for broken wires and corroded connectors, and any applicable corrective... unsafe condition as: In 2003, a number of reports had been received concerning broken wires and corroded... expected results; therefore, an improved separation bolt harness having part number (P/N) 7292520-691 has...

75 FR 28475 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and Model A340-300...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... unsafe condition as: In the door 2 area, the hat-racks are supplied with a basic wire harness which includes ``Oxygen Masks'' activation. In case of a monument installation, the respective non-used hat- rack... door 2 area, the hat-racks are supplied with a basic wire harness which includes ``Oxygen Masks...

Space Technology for the Fire Department

NASA Technical Reports Server (NTRS)

1986-01-01

A National Bureau of Standards/NASA project directed by Johnson resulted in a lightweight breathing system including face mask, frame, harness and air bottle marketed by Scott Aviation. Aluminum composite material was used; frame and harness were easier to put on and take off. Today every major manufacturer of breathing apparatus incorporates NASA technology in some form, and inhalation injuries have been reduced.

Usability issues concerning child restraint system harness design.

PubMed

Rudin-Brown, Christina M; Kumagai, Jason K; Angel, Harry A; Iwasa-Madge, Kim M; Noy, Y Ian

2003-05-01

A study was conducted to assess usability issues relating to child restraint system (CRS) harness design. Four convertible child restraint systems representing a wide variety of design features were used. Forty-two participants installed two child test dummies in both forward- and rear-facing configurations either inside or outside a test vehicle. Observer-scored checklists determined the degree to which each harness was installed correctly. Participant-scored questionnaires evaluated the 'ease-of-use' of various design features. While the percentage of correct installations exceeded 83% for all designs when installed in the forward-facing configuration, in the rear-facing position (that intended for children under 9-10 kg), there was a significant (between 65 and 89%) percentage of incorrect installations for all models. This finding is of particular interest and may be indicative of a more generalized problem with 'convertible' CRS designs when they are used in the rear-facing configuration. Furthermore, while certain design features were perceived by users as providing significantly better protection in the event of a collision, these also tended to be the features that were misused most often. The benefits and costs of various design features are discussed, and a method to test harness design usability is presented.

Effects of harness-attached transmitters on premigration and reproduction of Brant

USGS Publications Warehouse

Ward, David H.; Flint, Paul L.

1995-01-01

Radio transmitters are an important tool in waterfowl ecology studies, but little is known about their effects on free-ranging geese. We attached transmitters to female brant (Branta bernicla nigricans) to investigate migration schedules at a fall staging area, return rates to nesting grounds, and nesting rates of returning females in subsequent breeding seasons. Radio-tagged females (n = 62) carried either 35-g back-mounted transmitters attached with ribbon harnesses, or 26- or 32-g back-mounted transmitters affixed with plastic-coated wire harnesses (Dwyer 1972). Arrival and departure schedules at Izembek Lagoon, Alaska, did not differ (P > 0.05) between radio-tagged females and the entire population in 1987-89. Color-banded females with transmitters returned to the breeding colony in subsequent nesting seasons (1988-92) at a lower (P ≤ 0.003) rate (≤4%) than color-banded females without transmitters (57-83%). The 1 returning color-banded female with a transmitter did not breed, while an average 90% of the returning color-banded females without transmitters nested in subsequent breeding seasons (P = 0.005). Back-mounted, harness-attached transmitters may bias data in studies of waterfowl behavior, productivity, and survival.

Mapping the Sea Floor of the Historic Area Remediation Site (HARS) Offshore of New York City

USGS Publications Warehouse

Butman, Bradford

2002-01-01

The area offshore of New York City has been used for the disposal of dredged material for over a century. The area has also been used for the disposal of other materials such as acid waste, industrial waste, municipal sewage sludge, cellar dirt, and wood. Between 1976 and 1995, the New York Bight Dredged Material Disposal Site, also known as the Mud Dump Site (MDS), received on average about 6 million cubic yards of dredged material annually. In September 1997 the MDS was closed as a disposal site, and it and the surrounding area were designated as the Historic Area Remediation Site (HARS). The sea floor of the HARS, approximately 9 square nautical miles in area, currently is being remediated by placing a minimum 1-m-thick cap of clean dredged material on top of the surficial sediments that are contaminated from previous disposal of dredged and other materials. The U.S. Geological Survey (USGS) is working cooperatively with the U.S. Army Corps of Engineers (USACE) to map the sea floor geology of the HARS and changes in the characteristics of the surficial sediments over time.

High-Speed Additive Manufacturing Through High-Aspect-Ratio Nozzles

NASA Astrophysics Data System (ADS)

Shaw, Leon; Islam, Mashfiqul; Li, Jie; Li, Ling; Ayub, S. M. Imran

2018-03-01

The feasibility of layer-by-layer manufacturing through high-aspect-ratio (HAR) nozzles for microextrusion of paste to deposit planes has been investigated. Various conditions for paste extrusion, including nozzle moving speed, piston speed, extrusion rate, and distance between the nozzle tip and substrate, have been evaluated. By linking various microextrusion parameters together with the aid of a critical distance concept derived from microextrusion using circular nozzles and addressing the extrusion delay in response to the change of the piston speed and air pocket problems properly, we successfully microextruded single planes, multilayer objects, and larger planes made of multiple smaller planes side by side through HAR nozzles. It is further demonstrated that the X- Y dimensions of an extruded plane in the steady-state extrusion stage are determined by the nozzle travel distance and the length of the HAR nozzle opening if microextrusion is conducted with proper conditions. However, the height of the extruded plane is not only determined by the microextrusion conditions, but also affected by the drying shrinkage of the paste after microextrusion. This demonstration of the feasibility of using a HAR nozzle machine opens the door to manufacture of multimaterial, multilayer devices with high productivity in the near future.

Effects of radio transmitters on migrating wood thrushes

USGS Publications Warehouse

Powell, L.A.; Krementz, D.G.; Lang, J.D.; Conroy, M.J.

1998-01-01

We quantified the effects of radio transmitters on Wood Thrushes (Hylocichla mustelina) using 4 yr of banding and telemetry data from Piedmont National Wildlife Refuge, Georgia. Flight performance models suggest that the 1.6-g transmitter shortens the migratory range of Wood Thrushes by only 60 km, and the estimated migratory range is adequate to accomplish migration even with limited fat stores. We used two strengths of line, 5- and 9-kg test-strength braided Dacron, to attach the transmitters using the thigh-harness method. We recaptured 13 returning radio-marked Wood Thrushes, seven of which were still marked. Six of the seven birds marked with the 5-kg test harnesses lost their transmitters within 1 yr while all six of the 9-kg test harnesses were still attached up to 21 mo later. Radio-marking did not reduce the return rates of adults and immatures, and the transmitters did not cause radio-marked birds to lose more mass than banded-only birds. Wood Thrushes can successfully carry a transmitter during migration with no detectable negative effects. We recommend continued use of the thigh-harness method, but we encourage the use of 5-kg cotton line.

Research progress and harnessing method of soil and water loss in Pisha Sandstone region

NASA Astrophysics Data System (ADS)

Xiao, P. Q.; Yang, C. X.; Jing, C. R.

2018-05-01

Pisha Sandstone region is the most vulnerable and the most dramatic area of soil erosion, severe soil erosion on the ecological bases of China’s energy security constitutes a serious challenge. Research progress of soil erosion in pisha Sandstone region was reviewed based on the need of soil and water ecological construction in Pisha Sandstone region and harnessing the yellow river including soil erosion mechanism, soil erosion dynamic monitoring and soil erosion simulation assessments. Meanwhile, the latest progress of soil and water conservation measures was analyzed, and the existing problems and future harnessing measures of soil and water loss were discussed. This study is to explore the comprehensive management method and provide scientific theory for constructing soil and water conservation project in Pisha Sandstone region.

Thermal and Electrical Conductivity Measurements of CDA 510 Phosphor Bronze

NASA Technical Reports Server (NTRS)

Tuttle, James E.; Canavan, Edgar; DiPirro, Michael

2009-01-01

Many cryogenic systems use electrical cables containing phosphor bronze wire. While phosphor bronze's electrical and thermal conductivity values have been published, there is significant variation among different phosphor bronze formulations. The James Webb Space Telescope (JWST) will use several phosphor bronze wire harnesses containing a specific formulation (CDA 510, annealed temper). The heat conducted into the JWST instrument stage is dominated by these harnesses, and approximately half of the harness conductance is due to the phosphor bronze wires. Since the JWST radiators are expected to just keep the instruments at their operating temperature with limited cooling margin, it is important to know the thermal conductivity of the actual alloy being used. We describe an experiment which measured the electrical and thermal conductivity of this material between 4 and 295 Kelvin.

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases

PubMed Central

Puffenberger, Erik G.; Jinks, Robert N.; Sougnez, Carrie; Cibulskis, Kristian; Willert, Rebecca A.; Achilly, Nathan P.; Cassidy, Ryan P.; Fiorentini, Christopher J.; Heiken, Kory F.; Lawrence, Johnny J.; Mahoney, Molly H.; Miller, Christopher J.; Nair, Devika T.; Politi, Kristin A.; Worcester, Kimberly N.; Setton, Roni A.; DiPiazza, Rosa; Sherman, Eric A.; Eastman, James T.; Francklyn, Christopher; Robey-Bond, Susan; Rider, Nicholas L.; Gabriel, Stacey; Morton, D. Holmes; Strauss, Kevin A.

2012-01-01

The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children. Among the Plain people, we have used single nucleotide polymorphism (SNP) microarrays to genetically map recessive disorders to large autozygous haplotype blocks (mean = 4.4 Mb) that contain many genes (mean = 79). For some, uninformative mapping or large gene lists preclude disease-gene identification by Sanger sequencing. Seven such conditions were selected for exome sequencing at the Broad Institute; all had been previously mapped at the CSC using low density SNP microarrays coupled with autozygosity and linkage analyses. Using between 1 and 5 patient samples per disorder, we identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. Our results reveal the power of coupling new genotyping technologies to population-specific genetic knowledge and robust clinical data. PMID:22279524

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

PubMed

Harrington, Lucas B; Doxzen, Kevin W; Ma, Enbo; Liu, Jun-Jie; Knott, Gavin J; Edraki, Alireza; Garcia, Bianca; Amrani, Nadia; Chen, Janice S; Cofsky, Joshua C; Kranzusch, Philip J; Sontheimer, Erik J; Davidson, Alan R; Maxwell, Karen L; Doudna, Jennifer A

2017-09-07

CRISPR-Cas9 proteins function within bacterial immune systems to target and destroy invasive DNA and have been harnessed as a robust technology for genome editing. Small bacteriophage-encoded anti-CRISPR proteins (Acrs) can inactivate Cas9, providing an efficient off switch for Cas9-based applications. Here, we show that two Acrs, AcrIIC1 and AcrIIC3, inhibit Cas9 by distinct strategies. AcrIIC1 is a broad-spectrum Cas9 inhibitor that prevents DNA cutting by multiple divergent Cas9 orthologs through direct binding to the conserved HNH catalytic domain of Cas9. A crystal structure of an AcrIIC1-Cas9 HNH domain complex shows how AcrIIC1 traps Cas9 in a DNA-bound but catalytically inactive state. By contrast, AcrIIC3 blocks activity of a single Cas9 ortholog and induces Cas9 dimerization while preventing binding to the target DNA. These two orthogonal mechanisms allow for separate control of Cas9 target binding and cleavage and suggest applications to allow DNA binding while preventing DNA cutting by Cas9. Copyright © 2017 Elsevier Inc. All rights reserved.

Membrane Fusion Proteins as Nanomachines

NASA Astrophysics Data System (ADS)

Tamm, Lukas

2009-03-01

Membrane fusion is key to fertilization, virus infection, and neurotransmission. Specific proteins work like nanomachines to stitch together fluid, yet highly ordered lipid bilayers. The energy gained from large exothermic conformational changes of these proteins is utilized to fuse lipid bilayers that do not fuse spontaneously. Structural studies using x-ray crystallography and NMR spectroscopy have yielded detailed information about architecture and inner workings of these molecular machines. The question now is: how is mechanical energy gained from such protein transformations harnessed to transform membrane topology? To answer this question, we have determined that a boomerang-shaped structure of the influenza fusion peptide is critical to generate a high-energy binding intermediate in the target membrane and to return the ``boomerang'' to its place of release near the viral membrane for completion of the fusion cycle. In presynaptic exocytosis, receptor and acceptor SNAREs are zippered to form a helical bundle that is arrested shortly before the membrane. Ca binding to interlocked synaptotagmin releases the fusion block. Structural NMR and single molecule fluorescence data are combined to arrive at and further refine this picture.

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

PubMed Central

Rohle, Dan; Popovici-Muller, Janeta; Palaskas, Nicolaos; Turcan, Sevin; Grommes, Christian; Campos, Carl; Tsoi, Jennifer; Clark, Owen; Oldrini, Barbara; Komisopoulou, Evangelia; Kunii, Kaiko; Pedraza, Alicia; Schalm, Stefanie; Silverman, Lee; Miller, Alexandra; Wang, Fang; Yang, Hua; Chen, Yue; Kernytsky, Andrew; Rosenblum, Marc K.; Liu, Wei; Biller, Scott A.; Su, Shinsan M.; Brennan, Cameron W.; Chan, Timothy A.; Graeber, Thomas G.; Yen, Katharine E.; Mellinghoff, Ingo K.

2013-01-01

The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One potential drug target is isocitrate dehydrogenase 1 (IDH1), which is mutated in multiple human cancers. Here, we examine the role of mutant IDH1 in fully transformed cells with endogenous IDH1 mutations. A selective R132H-IDH1 inhibitor (AGI-5198) identified through a high-throughput screen blocked, in a dose-dependent manner, the ability of the mutant enzyme (mIDH1) to produce R-2-hydroxyglutarate (R-2HG). Under conditions of near-complete R-2HG inhibition, the mIDH1 inhibitor induced demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation. Blockade of mIDH1 impaired the growth of IDH1-mutant—but not IDH1–wild-type—glioma cells without appreciable changes in genome-wide DNA methylation. These data suggest that mIDH1 may promote glioma growth through mechanisms beyond its well-characterized epigenetic effects. PMID:23558169

Polyhedral Boranes: A Versatile Building Block for Nanoporous Materials

NASA Astrophysics Data System (ADS)

Clingerman, Daniel Jon

The studies described in this dissertation examine several new concepts related to polyhedral boranes and their applications towards the synthesis of novel nanoporous materials. The unique thermal and chemical robustness, rigidity, quasi-spherical geometry, and high boron content of polyhedral boranes are explored to generate materials not possible with typical organic synthons. Aside from the fundamental synthetic work, this work was also aimed at solving larger global issues such as energy storage and new routes to therapeutics. Chapter 2 highlights the discovery of the first highly porous carborane-based metal-organic framework, where the spherical nature of the carborane increases volumetric surface area without reducing pore volume. Chapter 3 examines the first tritopic carborane-based ligand and the stabilizing effect the rigid, sterically bulky carboranyl groups have on highly porous topologies not stable with typical organic ligands. Chapters 4 and 5 describe the use of polyhedral borane-based ligands as a means to influence and generate unexpected topologies. Lastly, chapter 6 explores using a simple carborane-based ligand that harnesses the power of coordination-driven assembly to rapidly generate a high boron-containing supramolecular cuboctahedron.

Correlation of Radiation Dose Estimates by DIC with the METREPOL Hematological Classes of Disease Severity.

PubMed

Port, M; Pieper, B; Dörr, H D; Hübsch, A; Majewski, M; Abend, M

2018-05-01

The degree of severity of hematologic acute radiation syndrome (HARS) may vary across the range of radiation doses, such that dose alone may be a less reliable predictor of clinical course. We sought to elucidate the relationship between absorbed dose and risk of clinically relevant HARS in humans. We used the database SEARCH (System for Evaluation and Archiving of Radiation Accidents based on Case Histories), which contains the histories of radiation accident victims. From 153 cases we extracted data on dose estimates using the dicentric assay to measure individual biological dosimetry. The data were analyzed according to the corresponding hematological response categories of clinical significance (H1-4). These categories are derived from the medical treatment protocols for radiation accident victims (METREPOL) and represent the clinical outcome of HARS based on severity categories ranging from 1-4. In addition, the category H0 represents a post-exposure hematological response that is within the normal range for nonexposed individuals. Age at exposure, gender and ethnicity were considered as potential confounders in unconditional cumulative logistic regression analysis. In most cases, victims were Caucasian (82.4%) and male (92.8%), who originated from either the Chernobyl (69.3%) or Goiânia (10.5%) accident, and nearly 60% were aged 20-40 years at time of exposure. All individuals were whole-body exposed (mean 3.8 Gy, stdev ±3.1), and single exposures were predominantly reported (79%). Seventy percent of victims in category H0 were exposed to ≤1 Gy, with rapidly decreasing proportions of H0 seen at doses up to 5 Gy. There were few HARS H4 cases reported at exposed dose of 1-2 Gy, while 82% of H4 cases received doses of >5 Gy. HARS H1-3 cases varied among dose ranges from 1-5 Gy. In summary, single whole-body radiation doses <1 Gy and >5 Gy corresponded in general with H0 and H3-4, respectively, and this was consistent with medical expectations. This underlines the usefulness of dose estimates for HARS prediction. However, whole-body doses between 1-5 Gy poorly corresponded to HARS H1-3. The dose range of 1-5 Gy was of limited value for medical decision-making regarding, e.g., hospitalization for H2-3, but not H1 and treatment decisions that differ between H1-3. Also, there were some H0 cases at high doses and H2-4 cases at low doses, thereby challenging an individual recommendation based solely on dose.

Harnessing the Potential of Additive Manufacturing

DTIC Science & Technology

2016-12-01

manufacturing age, which is dominated by standards for materials, processes and process control. Conventional manufacturing is based upon a design that is...documented either in a drawing or a computer-aided design (CAD) file. The manufacturing team then develops a docu- mented public or private process for...31 Defense AT&L: November-December 2016 Harnessing the Potential of Additive Manufacturing Bill Decker Decker is director of Technology

Detecting Contaminated Drinking Water: Harnessing Consumer Complaints

DTIC Science & Technology

2004-11-10

indicators of contaminated water, before effected people seek medical assistance. One of the most important qualities of drinking water consumers is...of people exposed to the contaminated water. 9. Consumer complaints can be helpful in determining the location of and isolating contaminated...Water: Harnessing Consumer Complaints Andrew J. Whelton 1 , Andrea M. Dietrich 2 , Gary A. Burlingame 3 , Margaret F. Cooney 1 1 U.S. Army

Hello World: Harnessing social media for the Rosetta mission

NASA Astrophysics Data System (ADS)

Baldwin, E.; Mignone, C.; O'Flaherty, K. S.; Homfeld, A.-M.; Bauer, M.; McCaughrean, M. J.

2015-10-01

The European Space Agency's (ESA) comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. By harnessing a range of platforms for communicating the key messages of this unprecedented space adventure as the spacecraft reached its destination ten years later, a wide range of new audiences were reached and could follow this once-in-a-lifetime mission.

MicroRNA Expression for Early Prediction of Late Occurring Hematologic Acute Radiation Syndrome in Baboons.

PubMed

Port, Matthias; Herodin, Francis; Valente, Marco; Drouet, Michel; Ullmann, Reinhard; Doucha-Senf, Sven; Lamkowski, Andreas; Majewski, Matthäus; Abend, Michael

2016-01-01

For effective medical management of radiation-exposed persons after a radiological/nuclear event, blood-based screening measures in the first few days that could predict hematologic acute radiation syndrome (HARS) are needed. For HARS severity prediction, we used microRNA (miRNA) expression changes measured on days one and two after irradiation in a baboon model. Eighteen baboons underwent different patterns of partial or total body irradiation, corresponding to an equivalent dose of 2.5 or 5 Gy. According to changes in blood cell counts (BCC) the surviving baboons (n = 17) exhibited mild (H1-2, n = 4) or more severe (H2-3, n = 13) HARS. In a two Stage study design we screened 667 miRNAs using a quantitative real-time polymerase chain reaction (qRT-PCR) platform. In Stage II we validated candidates where miRNAs had to show a similar regulation (up- or down-regulated) and a significant 2-fold miRNA expression difference over H0. Seventy-two candidate miRNAs (42 for H1-2 and 30 for H2-3) were forwarded for validation. Forty-two of the H1-2 miRNA candidates from the screening phase entered the validation step and 20 of them showed a statistically significant 2-4 fold up-regulation relative to the unexposed reference (H0). Fifteen of the 30 H2-3 miRNAs were validated in Stage II. All miRNAs appeared 2-3 fold down-regulated over H0 and allowed an almost complete separation of HARS categories; the strongest candidate, miR-342-3p, showed a sustained and 10-fold down-regulation on both days 1 and 2. In summary, our data support the medical decision making of the HARS even within the first two days after exposure where diagnostic tools for early medical decision are required but so far missing. The miRNA species identified and in particular miR-342-3p add to the previously identified mRNAs and complete the portfolio of identified mRNA and miRNA transcripts for HARS prediction and medical management.

Comparison of Piezo-material based Energy Transduction Systems for Artificial Nanoswimmer

NASA Astrophysics Data System (ADS)

Nain, S.; Rathore, J. S.; Sharma, N. N.

2018-04-01

The energy harnessing is a process of obtaining energy from the surrounding environment and converting into electrical energy. In the last two decades, there has been a plenteous study in energy harnessing. Now a day, energy harnessing using piezoelectric materials has drawn attention of researchers due to low cost, flexibility and light weight. The benefits of piezoelectric material can be utilized by designing a self-powered device for artificial nanoswimmer. Some of the ceramics which displays the piezoelectric effect are lead-zirconate-titanate (PZT), lead-titanate (PbTiO2), lead-zirconate (PbZrO3) and Barium Titanate (BaTiO3). PZT is most extensively used piezoelectric material in the field of energy harnessing but it is brittle in nature. Lead based piezoelectric materials are toxic in nature and may not suitable for in-vivo biomedical applications. To eradicate this problem, researchers are interested in synthesizing lead free piezoelectric material such as Aluminium Nitride (AIN), Barium Titanate (BaTiO3) and Polyvinylidenefluoride (PVDF). The biocompatibility of PVDF makes it appropriate to be used for energy harnessing in human body for applications like on board powering of nanoswimmer for various disease detection and drug delivery. In this paper, a cantilever beam is being simulated in COMSOL to study electric potential generated on the surface of beam made of different piezoelectric materials such as AIN, PVDF and PZT due to fluidic pressure, which will be utilized as energy for actuation of artificial nanoswimmer. Piezo-based cantilever beams have been compared and maximum electric potential is being observed in PVDF based beam. PVDF seems most promising piezoelectric material for in-vivo biomedical application and it is readily available.

Failed Pavlik harness treatment for DDH as a risk factor for avascular necrosis.

PubMed

Tiruveedhula, Madhu; Reading, Isabel C; Clarke, Nicholas M P

2015-03-01

Avascular necrosis (AVN) of the femoral head is an irreversible complication seen in the treatment of developmental dysplasia of hip (DDH) with the Pavlik harness. Its incidence is reported to be low after successful reduction of the hip but high if the hip is not concentrically relocated. We aim to investigate its incidence after failed Pavlik harness treatment. We prospectively followed up a group of children who failed Pavlik harness treatment for DDH treated at our institution by the senior author between 1988 and 2001 and compared their rates of AVN with a group of children who presented late and hence were treated surgically. AVN was graded as described by Kalamchi and MacEwen and only grade 2 to 4 AVN was considered significant and included in the analysis. Thirty-seven hips were included in the failed Pavlik group (group 1) and 86 hips in the no Pavlik group (group 2). Ten hips in group 1 developed AVN (27%), whereas only 7 hips in group 2 (8%) developed AVN; the odds of developing AVN after failed Pavlik treatment was 4.7 (95% confidence interval, 1.3-14.1) (P=0.009) with a relative risk of 3.32 (range, 1.37 to 8.05). There was no statistically significant association observed with duration of splintage and severity of AVN (Spearman's correlation, -0.46; P=0.18). However, there was a positive correlation noted with age at presentation and severity of AVN. Therefore, we advise close monitoring of hips in the Pavlik harness and discontinue its use if the hips are not reduced within 3 weeks. Level III.

The pubo-femoral distance decreases with Pavlik harness treatment for developmental dysplasia of the hip in newborns.

PubMed

Maranho, Daniel Augusto; Donati, Felipe Nunes; Dalto, Vitor Faeda; Nogueira-Barbosa, Marcello Henrique

2017-09-01

To evaluate the evolution of the ultrasonographic pubo-femoral distance (PFD) before and after Pavlik harness treatment for developmental dysplasia of the hip (DDH) in newborns. Twenty-five patients (16.7 ± 10.4 days; 19 females, six males) diagnosed with DDH and treated using the Pavlik harness were included. Eighteen patients had bilateral, and seven unilateral DDH, with a total of 43 dysplastic hips. The seven non-dysplastic hips in unilateral cases were used for comparison. The PFD was measured in the coronal and axial planes with the hip flexed to approximately 90°, before and after an average of 93 days of treatment. The femoral head coverage was assessed in the coronal plane, and correlated with PFD values. In dysplastic hips, the mean PFD decreased from 6.1 ± 1.8 mm to 3.0 ± 0.7 mm in the axial (adjusted difference, 2.9 mm; p < 0.01), and from 5.9 ± 2.0 to 3.0 ± 0.6 mm in the coronal plane (adjusted difference 2.7 mm; p < 0.01). The femoral head coverage increased from 30.8 to 62.1%, and the mean differences of femoral head coverage and PFD were significantly correlated (p < 0.001). There was no difference between treated dysplastic and non-dysplastic hips. There was high intra- and inter-observer agreement for PFD measurements. The PFD decreased significantly after DDH treatment using the Pavlik harness in newborns, and showed significant correlation with the femoral head coverage improvement. PFD might be a reliable tool for monitoring DDH treatment in newborns treated using the Pavlik harness.

Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.

PubMed

Chua, Hui Lin; Plett, P Artur; Sampson, Carol H; Katz, Barry P; Carnathan, Gilbert W; MacVittie, Thomas J; Lenden, Keith; Orschell, Christie M

2014-01-01

In an effort to expand the worldwide pool of available medical countermeasures (MCM) against radiation, the PEGylated G-CSF (PEG-G-CSF) molecules Neulasta and Maxy-G34, a novel PEG-G-CSF designed for increased half-life and enhanced activity compared to Neulasta, were examined in a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS), along with the lead MCM for licensure and stockpiling, G-CSF. Both PEG-G-CSFs were shown to retain significant survival efficacy when administered as a single dose 24 h post-exposure, compared to the 16 daily doses of G-CSF required for survival efficacy. Furthermore, 0.1 mg kg of either PEG-G-CSF affected survival of lethally-irradiated mice that was similar to a 10-fold higher dose. The one dose/low dose administration schedules are attractive attributes of radiation MCM given the logistical challenges of medical care in a mass casualty event. Maxy-G34-treated mice that survived H-ARS were examined for residual bone marrow damage (RBMD) up to 9 mo post-exposure. Despite differences in Sca-1 expression and cell cycle position in some hematopoietic progenitor phenotypes, Maxy-G34-treated mice exhibited the same degree of hematopoietic stem cell (HSC) insufficiency as vehicle-treated H-ARS survivors in competitive transplantation assays of 150 purified Sca-1+cKit+lin-CD150+cells. These data suggest that Maxy-G34, at the dose, schedule, and time frame examined, did not mitigate RBMD but significantly increased survival from H-ARS at one-tenth the dose previously tested, providing strong support for advanced development of Maxy-G34, as well as Neulasta, as MCM against radiation.

Relative prevalence of upper respiratory tract obstructive disorders in two breeds of harness racehorses (185 cases: 1998-2006).

PubMed

Strand, E; Fjordbakk, C T; Sundberg, K; Spangen, L; Lunde, H; Hanche-Olsen, S

2012-09-01

Two genetically and phenotypically distinct horse breeds are used for harness racing in Scandinavia: the Standardbred (SB) and Coldblooded Trotter. These racehorses have identical environmental, management and racing conditions. Therefore, this study was undertaken to identify and compare the relative prevalence of upper respiratory tract (URT) obstructive disorders in these 2 breeds. To determine whether these 2 phenotypically different breeds of harness racehorses have different predispositions for URT disorders. Retrospective study of 88 Norwegian Coldblooded Trotters (NCT) and 97 SBs referred to this hospital for URT evaluation between 1998 and 2006. Case records of all horses diagnosed with an URT disorder during resting endoscopy, and all horses undergoing high-speed treadmill videoendoscopy (HSTV) with one or more periods of induced poll flexion were evaluated. The relative prevalence of URT disorders between the 2 breeds was analysed using a Fisher's exact test. There was a significant (P<0.05) breed predisposition regarding 6 URT disorders. Bilateral dynamic laryngeal collapse associated with poll flexion and flaccid epiglottis was significantly more frequent in the NCT. Alar fold collapse and nasopharyngeal collapse were significantly more frequent in SBs. Epiglottic entrapment and nasal flutter were only diagnosed in the SBs. Dynamic disorders were more common than resting disorders in both breeds. URT obstructive disorders (dynamic laryngeal collapse associated with poll flexion, flaccid epiglottis, pharyngeal collapse, alar fold collapse, nasal flutter and epiglottic entrapment) are breed related, indicating an anatomic or functional cause. Periods of induced poll flexion during HSTV was essential to declare harness racehorses free of URT disorders. Further anatomic or physiological studies comparing these breeds could potentially provide insight into the pathogenesis of certain URT obstructive disorders. Induced poll flexion should be included in routine HSTV examinations of all harness racehorses. © 2011 EVJ Ltd.

Computer-Aided Engineering Of Cabling

NASA Technical Reports Server (NTRS)

Billitti, Joseph W.

1989-01-01

Program generates data sheets, drawings, and other information on electrical connections. DFACS program, centered around single data base, has built-in menus providing easy input of, and access to, data for all personnel involved in system, subsystem, and cabling. Enables parallel design of circuit-data sheets and drawings of harnesses. Also recombines raw information to generate automatically various project documents and drawings, including index of circuit-data sheets, list of electrical-interface circuits, lists of assemblies and equipment, cabling trees, and drawings of cabling electrical interfaces and harnesses. Purpose of program to provide engineering community with centralized data base for putting in, and gaining access to, functional definition of system as specified in terms of details of pin connections of end circuits of subsystems and instruments and data on harnessing. Primary objective to provide instantaneous single point of interchange of information, thus avoiding

Ultra-high aspect ratio replaceable AFM tips using deformation-suppressed focused ion beam milling.

PubMed

Savenko, Alexey; Yildiz, Izzet; Petersen, Dirch Hjorth; Bøggild, Peter; Bartenwerfer, Malte; Krohs, Florian; Oliva, Maria; Harzendorf, Torsten

2013-11-22

Fabrication of ultra-high aspect ratio exchangeable and customizable tips for atomic force microscopy (AFM) using lateral focused ion beam (FIB) milling is presented. While on-axis FIB milling does allow high aspect ratio (HAR) AFM tips to be defined, lateral milling gives far better flexibility in terms of defining the shape and size of the tip. Due to beam-induced deformation, it has so far not been possible to define HAR structures using lateral FIB milling. In this work we obtain aspect ratios of up to 45, with tip diameters down to 9 nm, by a deformation-suppressing writing strategy. Several FIB milling strategies for obtaining sharper tips are discussed. Finally, assembly of the HAR tips on a custom-designed probe as well as the first AFM scanning is shown.

Engineering and experimental analyses of the tensile loads applied during strength testing of direct bonded orthodontic brackets.

PubMed

Katona, T R; Chen, J

1994-08-01

The stress levels within the cement layer (hence, the apparent strength) of a direct bonded orthodontic bracket depends, to a large extent, on the alignment of the tensile loads that are applied to the specimen. The purpose of this analysis was to determine how the construction of a ligature wire harness affects the alignment of the applied loads. Tensile tests conducted on a modified bracket/cement system showed large variations in the force-elongation curve profiles. An engineering model was developed to explain these deviations. The results indicate that it is virtually impossible to evenly apply tensile loads to the bracket. It was also proposed that long harnesses constructed with thin ligature wire, prestressing the harness, and lubrication may reduce some of the effects of unavoidable load-bracket misalignment.

Characterization of WY 14,643 and its Complex with Aldose Reductase

PubMed Central

Sawaya, Michael R.; Verma, Malkhey; Balendiran, Vaishnavi; Rath, Nigam P.; Cascio, Duilio; Balendiran, Ganesaratnam K.

2016-01-01

The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements of the equilibrium dissociation constants, Kd, of oxidized (hAR•NADP+) and reduced (hAR•NADPH) holoenzyme complexes display a 2-fold difference between them. Kd values for the dissociation of WY 14,643 from the oxidized (hAR•NADP+•WY 14,643) and reduced (hAR•NADPH•WY 14,643) ternary complexes are comparable to each other. The ternary complex structure of hAR•NADP+•WY 14,643 reveals the first structural evidence of a fibrate class drug binding to hAR. These observations demonstrate how fibrate molecules such as WY 14,643, besides being valued as agonists for PPAR, also inhibit hAR. PMID:27721416

Pakistan’s Law Enforcement Agencies -- Harnessing their Potential to Combat Terrorism

DTIC Science & Technology

2008-12-01

can be easily varied, and that has been a common phenomenon in the recent past . 55 maintaining law and order in the province.145 This force...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for pubic release; distribution is unlimited PAKISTAN’S LAW ...REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE: Pakistan’s Law Enforcement Agencies - Harnessing their Potential to Combat

Harnessing the Power of Vision. Ten Steps to Creating a Strategic Vision and Action Plan for Your Community. Preparing Your Community for the 21st Century Series.

ERIC Educational Resources Information Center

Peterson, Mark

This extension education publication contains insights and tools to help community members develop a strategic vision and action plan for their community. Presented first are an executive summary and an introduction that includes 10 reasons for a strategic visioning process. The first section, which deals with harnessing the power of vision,…

Effect of Bypass Capacitor in Common-mode Noise Reduction Technique for Automobile PCB

NASA Astrophysics Data System (ADS)

Uno, Takanori; Ichikawa, Kouji; Mabuchi, Yuichi; Nakamura, Atushi

In this letter, we studied the use of common mode noise reduction technique for in-vehicle electronic equipment, each comprising large-scale integrated circuit (LSI), printed circuit board (PCB), wiring harnesses, and ground plane. We have improved the model circuit of the common mode noise that flows to the wire harness to add the effect of by-pass capacitors located near an LSI.

High-Density Terminal Box for Testing Wire Harness

NASA Technical Reports Server (NTRS)

Pierce, W. B.; Collins, W. G.

1982-01-01

Compact terminal box provides access to complex wiring harnesses for testing. Box accommodates more than twice as many wires as previous boxes. Box takes in wires via cable connectors and distributes them to contacts on box face. Instead of separate insulated jacks in metal face panel, box uses pairs of small military-standard metal sockets in precision-drilled plastic panel. Shorting plug provides continuity for wires when not being tested.

MIT-Skywalker: considerations on the Design of a Body Weight Support System.

PubMed

Gonçalves, Rogério Sales; Krebs, Hermano Igo

2017-09-06

To provide body weight support during walking and balance training, one can employ two distinct embodiments: support through a harness hanging from an overhead system or support through a saddle/seat type. This paper presents a comparison of these two approaches. Ultimately, this comparison determined our selection of the body weight support system employed in the MIT-Skywalker, a robotic device developed for the rehabilitation/habilitation of gait and balance after a neurological injury. Here we will summarize our results with eight healthy subjects walking on the treadmill without any support, with 30% unloading supported by a harness hanging from an overhead system, and with a saddle/seat-like support system. We compared the center of mass as well as vertical and mediolateral trunk displacements across different walking speeds and support. The bicycle/saddle system had the highest values for the mediolateral inclination, while the overhead harness body weight support showed the lowest values at all speeds. The differences were statistically significant. We selected the bicycle/saddle system for the MIT-Skywalker. It allows faster don-and-doff, better centers the patient to the split treadmill, and allows all forms of training. The overhead harness body weight support might be adequate for rhythmic walking training but limits any potential for balance training.

The interstellar formation and spectra of the noble gas, proton-bound HeHHe+, HeHNe+ and HeHAr+ complexes

NASA Astrophysics Data System (ADS)

Stephan, Cody J.; Fortenberry, Ryan C.

2017-07-01

The sheer interstellar abundance of helium makes any bound molecules or complexes containing it of potential interest for astrophysical observation. This work utilizes high-level and trusted quantum chemical techniques to predict the rotational, vibrational and rovibrational traits of HeHHe+, HeHNe+ and HeHAr+. The first two are shown to be strongly bound, while HeHAr+ is shown to be more of a van der Waals complex of argonium with a helium atom. In any case, the formation of HeHHe+ through reactions of HeH+ with HeH3+ is exothermic. HeHHe+ exhibits the quintessentially bright proton-shuttle motion present in all proton-bound complexes in the 7.4 micron range making it a possible target for telescopic observation at the mid-/far-Infrared crossover point and a possible tracer for the as-of-yet unobserved helium hydride cation. Furthermore, a similar mode in HeHNe+ can be observed to the blue of this close to 6.9 microns. The brightest mode of HeHAr+ is dimmed due the reduced interaction of the helium atom with the central proton, but this fundamental frequency can be found slightly to the red of the Ar-H stretch in the astrophysically detected argonium cation.

MODELING H-ARS USING HEMATOLOGICAL PARAMETERS: A COMPARISON BETWEEN THE NON-HUMAN PRIMATE AND MINIPIG.

PubMed

Bolduc, David L; Bünger, Rolf; Moroni, Maria; Blakely, William F

2016-12-01

Multiple hematological biomarkers (i.e. complete blood counts and serum chemistry parameters) were used in a multivariate linear-regression fit to create predictive algorithms for estimating the severity of hematopoietic acute radiation syndrome (H-ARS) using two different species (i.e. Göttingen Minipig and non-human primate (NHP) (Macacca mulatta)). Biomarker data were analyzed prior to irradiation and between 1-60 days (minipig) and 1-30 days (NHP) after irradiation exposures of 1.6-3.5 Gy (minipig) and 6.5 Gy (NHP) 60 Co gamma ray doses at 0.5-0.6 Gy min -1 and 0.4 Gy min -1 , respectively. Fitted radiation risk and injury categorization (RRIC) values and RRIC prediction percent accuracies were compared between the two models. Both models estimated H-ARS severity with over 80% overall predictive power and with receiver operating characteristic curve area values of 0.884 and 0.825. These results based on two animal radiation models support the concept for the use of a hematopoietic-based algorithm for predicting the risk of H-ARS in humans. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Quantitative assessment of human body shape using Fourier analysis

NASA Astrophysics Data System (ADS)

Friess, Martin; Rohlf, F. J.; Hsiao, Hongwei

2004-04-01

Fall protection harnesses are commonly used to reduce the number and severity of injuries. Increasing the efficiency of harness design requires the size and shape variation of the user population to be assessed as detailed and as accurately as possible. In light of the unsatisfactory performance of traditional anthropometry with respect to such assessments, we propose the use of 3D laser surface scans of whole bodies and the statistical analysis of elliptic Fourier coefficients. Ninety-eight male and female adults were scanned. Key features of each torso were extracted as a 3D curve along front, back and the thighs. A 3D extension of Elliptic Fourier analysis4 was used to quantify their shape through multivariate statistics. Shape change as a function of size (allometry) was predicted by regressing the coefficients onto stature, weight and hip circumference. Upper and lower limits of torso shape variation were determined and can be used to redefine the design of the harness that will fit most individual body shapes. Observed allometric changes are used for adjustments to the harness shape in each size. Finally, the estimated outline data were used as templates for a free-form deformation of the complete torso surface using NURBS models (non-uniform rational B-splines).

Quick-disconnect harness system for helmet-mounted displays

NASA Astrophysics Data System (ADS)

Bapu, P. T.; Aulds, M. J.; Fuchs, Steven P.; McCormick, David M.

1992-10-01

We have designed a pilot's harness-mounted, high voltage quick-disconnect connectors with 62 pins, to transmit voltages up to 13.5 kV and video signals with 70 MHz bandwidth, for a binocular helmet-mounted display system. It connects and disconnects with power off, and disconnects 'hot' without pilot intervention and without producing external sparks or exposing hot embers to the explosive cockpit environment. We have implemented a procedure in which the high voltage pins disconnect inside a hermetically-sealed unit before the physical separation of the connector. The 'hot' separation triggers a crowbar circuit in the high voltage power supplies for additional protection. Conductor locations and shields are designed to reduce capacitance in the circuit and avoid crosstalk among adjacent circuits. The quick- disconnect connector and wiring harness are human-engineered to ensure pilot safety and mobility. The connector backshell is equipped with two hybrid video amplifiers to improve the clarity of the video signals. Shielded wires and coaxial cables are molded as a multi-layered ribbon for maximum flexibility between the pilot's harness and helmet. Stiff cabling is provided between the quick-disconnect connector and the aircraft console to control behavior during seat ejection. The components of the system have been successfully tested for safety, performance, ergonomic considerations, and reliability.

NREL at 40: It All Started With a Desire to Harness the Sun | News | NREL

Science.gov Websites

(PV) industry. Their job was to ultimately develop new solar technology and to chart a path toward its of reliability for PV modules and systems, helping bolster consumer and investor confidence in solar With a Desire to Harness the Sun July 5, 2017 Photo of PV panels under a bright blue sky. A PV array on

European Science Notes Information Bulletin Reports on Current European/ Middle Eastern Science

DTIC Science & Technology

1988-08-01

problems, and infrastructure and in- terfacing requirements. Development of Finite Element Software for Transputer-Based Parallel Processors ...Introduction will it be possible to harness these processors together to work on a common problem. The feasibility study at the UK’s Kent University for One of...the many problems in harnessing the power development of a distributed supercomputer is being of a large number of processors on a single problem is

Integration Evaluation of the Advanced Mission Extender Device Max

DTIC Science & Technology

2014-04-04

Figure 9. Pressure on collecting tube due to restraint harness design in left pilot seat of CH-47. The rating scores for comfort and functionality in...collecting tube due to restraint harness design in left pilot seat of CH-47. .......... 16  v Table of contents (continued) List of...USAF in 2009. The upgrades to the AMXDmax® included more automation, improvements to battery life, male cup comfort and collection bag design , plus a

Cable tester

NASA Astrophysics Data System (ADS)

Rammage, Robert L.

1990-10-01

A device for sequentially testing the plurality of connectors in a wiring harness is disclosed. The harness is attached to the tester by means of adapter cables and a rotary switch is used to sequentially, individually test the connectors by passing a current through the connector. If the connector is unbroken, a light will flash to show it is electrically sound. The adapters allow a large number of cable configurations to be tested using a single tester configuration.

Improving the crashworthiness of general aviation aircraft by crash injury investigations.

PubMed

Kirkham, W R

1982-04-01

An aircraft accident investigation program correlates injuries to occupants with the severity of impacts and structural changes in the crash. Findings brought to the attention of aircraft manufacturers have led to specific aircraft being made more crash-worthy. The finding of a failure in a shoulder harness attachment led to the strengthening of the attachment brace. The way a shoulder harness was joined to a lapbelt was modified following a noted failure. The finding of fractures of lapbelt and shoulder harness cable tiedowns led to the use of stronger cables and modification of the installation. Other findings resulted in a shoulder strap guide being placed on an inertia reel and a side-mounted seat being modified. Described also are three seat-related features which, although meeting FAA standards, during the dynamics of a crash may lack desirable energy attenuation. These findings illustrate the value of aircraft crash injury correlations.

Power Distribution for Cryogenic Instruments at 6-40K The James Webb Space Telescope Case

NASA Technical Reports Server (NTRS)

Rumler, Peter; Lundquist, Ray; Alvarez, Jose Lorenzo; Sincell, Jeff; Tuttle, Jim

2011-01-01

The Integrated Science Instrument Module (ISIM) of the James Webb Space Telescope (JWST) operates its instruments passively cooled at around 40 Kelvin (K), with a warm Instrument Electronic Compartment (IEC) at 300K attached to it. From the warm electronics all secondary signal and power harnesses have to bridge this 300-40K temperature difference and minimize the power dissipation and parasitic heat leak into the cold region. After an introduction of the ISIM with its instruments, the IEC with the electronics, and the harness architecture with a special radiator, this paper elaborates on the cryogenic wire selection and tests performed to establish current de-rating rules for different wire types. Finally failure modes are analyzed for critical instrument interfaces that could inject excessive currents and heat into the harness and cold side, and several solutions for the removal of such failures are presented.

Theoretical Study of Decomposition Pathways for HArF and HKrF

NASA Technical Reports Server (NTRS)

Chaban, Galina M.; Lundell, Jan; Gerber, R. Benny; Kwak, Donchan (Technical Monitor)

2002-01-01

To provide theoretical insights into the stability and dynamics of the new rare gas compounds HArF and HKrF, reaction paths for decomposition processes HRgF to Rg + HF and HRgF to H + Rg + F (Rg = Ar, Kr) are calculated using ab initio electronic structure methods. The bending channels, HRgF to Rg + HF, are described by single-configurational MP2 and CCSD(T) electronic structure methods, while the linear decomposition paths, HRgF to H + Rg + F, require the use of multi-configurational wave functions that include dynamic correlation and are size extensive. HArF and HKrF molecules are found to be energetically stable with respect to atomic dissociation products (H + Rg + F) and separated by substantial energy barriers from Rg + HF products, which ensure their kinetic stability. The results are compatible with experimental data on these systems.

Hybrid Alfven resonant mode generation in the magnetosphere-ionosphere coupling system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hiraki, Yasutaka; Watanabe, Tomo-Hiko

2012-10-15

Feedback unstable Alfven waves involving global field-line oscillations and the ionospheric Alfven resonator (IAR) were comprehensively studied to clarify their properties of frequency dispersion, growth rate, and eigenfunctions. It is discovered that a new mode called here the hybrid Alfven resonant (HAR) mode can be destabilized in the magnetosphere-ionosphere coupling system with a realistic Alfven velocity profile. The HAR mode found in a high frequency range over 0.3 Hz is caused by coupling of IAR modes with strong dispersion and magnetospheric cavity resonances. The harmonic relation of HAR eigenfrequencies is characterized by a constant frequency shift from those of IARmore » modes. The three modes are robustly found even if effects of two-fluid process and ionospheric collision are taken into account and thus are anticipated to be detected by magnetic field observations in a frequency range of 0.3-1 Hz in auroral and polar-cap regions.« less

Power Distribution For Cryogenic Instruments At 6-40K The James Webb Space Telescope Case

NASA Astrophysics Data System (ADS)

Rumler, Peter; Lundquist, Ray; Alvarez, Jose Lorenzo; Sincell, Jeff; Tuttle, Jim

2011-10-01

The Integrated Science Instrument Module (ISIM) of the James Webb Space Telescope (JWST) operates its instruments passively cooled at around 40 Kelvin (K), with a warm Instrument Electronic Compartment (IEC) at 300K attached to it. From the warm electronics all secondary signal and power harnesses have to bridge this 300-40K temperature difference and minimize the power dissipation and parasitic heat leak into the cold region. After an introduction of the ISIM with its instruments, the IEC with the electronics, and the harness architecture with a special radiator, this paper elaborates on the cryogenic wire selection and tests performed to establish current de-rating rules for different wire types. Finally failure modes are analyzed for critical instrument interfaces that could inject excessive currents and heat into the harness and cold side, and several solutions for the removal of such failures are presented.

World Bank: harnessing civil society expertise in undertaking and disseminating research findings.

PubMed

Simms, Ben

2013-01-01

The UK Consortium on AIDS and International Development was an essential partner to the evaluation leaders in harnessing the contribution and expertise of civil society. This article describes what the partnership entailed, the additional value it brought and how civil society might use the evaluation findings both as a tool for advocacy and a means for improving its own engagement with the individuals directly affected by HIV and with those who care for them.

The Enhancement of Concurrent Processing through Functional Programming Languages.

DTIC Science & Technology

1984-06-01

ta * functional programming languages allow us to harness the pro- cessing power of computers with hundreds or even thousands of DD I 1473 EDITION OF...that it might be the best way to make imperative library", programs into functional ones which are well suited to concurrent processing. Accession For...statements in their code. We assert that functional programming languajes allok us to harness the processing power of computers with hundre4s or even

76 FR 56284 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and Model A340-200 and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... describes the unsafe condition as: It was noticed in production that the distance between the wire harnesses 5376VB/2M and 5377VB/1M which are above the left-hand (LH) and right-hand (RH) door 4, and the air... production that the distance between the wire harnesses 5376VB/2M and 5377VB/1M which are above the left-hand...

Status of the JWST Science Instrument Payload

NASA Technical Reports Server (NTRS)

Greenhouse, Matt

2016-01-01

The James Webb Space Telescope (JWST) Integrated Science Instrument Module (ISIM) system consists of five sensors (4 science): Mid-Infrared Instrument (MIRI), Near Infrared Imager and Slitless Spectrograph (NIRISS), Fine Guidance Sensor (FGS), Near InfraRed Camera (NIRCam), Near InfraRed Spectrograph (NIRSpec); and nine instrument support systems: Optical metering structure system, Electrical Harness System; Harness Radiator System, ISIM Electronics Compartment, ISIM Remote Services Unit, Cryogenic Thermal Control System, Command and Data Handling System, Flight Software System, Operations Scripts System.

EMPReSS: European mouse phenotyping resource for standardized screens.

PubMed

Green, Eain C J; Gkoutos, Georgios V; Lad, Heena V; Blake, Andrew; Weekes, Joseph; Hancock, John M

2005-06-15

Standardized phenotyping protocols are essential for the characterization of phenotypes so that results are comparable between different laboratories and phenotypic data can be related to ontological descriptions in an automated manner. We describe a web-based resource for the visualization, searching and downloading of standard operating procedures and other documents, the European Mouse Phenotyping Resource for Standardized Screens-EMPReSS. Direct access: http://www.empress.har.mrc.ac.uk e.green@har.mrc.ac.uk.

A depth video sensor-based life-logging human activity recognition system for elderly care in smart indoor environments.

PubMed

Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin

2014-07-02

Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital.

A Depth Video Sensor-Based Life-Logging Human Activity Recognition System for Elderly Care in Smart Indoor Environments

PubMed Central

Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin

2014-01-01

Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital. PMID:24991942

Embedding human annoyance rate models in wireless smart sensors for assessing the influence of subway train-induced ambient vibration

NASA Astrophysics Data System (ADS)

Sun, Ke; Zhang, Wei; Ding, Huaping; Kim, Robin E.; Spencer, Billie F., Jr.

2016-10-01

The operation of subway trains induces ambient vibrations, which may cause annoyance and other adverse effects on humans, eventually leading to physical, physiological, and psychological problems. In this paper, the human annoyance rate (HAR) models, used to assess the human comfort under the subway train-induced ambient vibrations, were deduced and the calibration curves for 5 typical use circumstances were addressed. An autonomous measurement system, based on the Imote2, wireless smart sensor (WSS) platform, plus the SHM-H, high-sensitivity accelerometer board, was developed for the HAR assessment. The calibration curves were digitized and embedded in the computational core of the WSS unit. Experimental validation was conducted, using the developed system on a large underground reinforced concrete frame structure adjoining the subway station. The ambient acceleration of both basement floors was measured; the embedded computation was implemented and the HAR assessment results were wirelessly transmitted to the central server, all by the WSS unit. The HAR distributions of the testing areas were identified, and the extent to which both basements will be influenced by the close-up subway-train’s operation, in term of the 5 typical use circumstances, were quantitatively assessed. The potential of the WSS-based autonomous system for the fast environment impact assessment of the subway train-induced ambient vibration was well demonstrated.

Stress polishing demonstrator for ELT M1 segments and industrialization

NASA Astrophysics Data System (ADS)

Hugot, Emmanuel; Bernard, Anaïs.; Laslandes, Marie; Floriot, Johan; Dufour, Thibaut; Fappani, Denis; Combes, Jean Marc; Ferrari, Marc

2014-07-01

After two years of research and development under ESO support, LAM and Thales SESO present the results of their experiment for the fast and accurate polishing under stress of ELT 1.5 meter segments as well as the industrialization approach for mass production. Based on stress polishing, this manufacturing method requires the conception of a warping harness able to generate extremely accurate bending of the optical surface of the segments during the polishing. The conception of the warping harness is based on finite element analysis and allowed a fine tuning of each geometrical parameter of the system in order to fit an error budget of 25nm RMS over 300μm of bending peak to valley. The optimisation approach uses the simulated influence functions to extract the system eigenmodes and characterise the performance. The same approach is used for the full characterisation of the system itself. The warping harness has been manufactured, integrated and assembled with the Zerodur 1.5 meter segment on the LAM 2.5meter POLARIS polishing facility. The experiment consists in a cross check of optical and mechanical measurements of the mirrors bending in order to develop a blind process, ie to bypass the optical measurement during the final industrial process. This article describes the optical and mechanical measurements, the influence functions and eigenmodes of the system and the full performance characterisation of the warping harness.

Using HIV Surveillance Registry Data to Re-Link Persons to Care: The RSVP Project in San Francisco

PubMed Central

Buchacz, Kate; Chen, Miao-Jung; Parisi, Maree Kay; Yoshida-Cervantes, Maya; Antunez, Erin; Delgado, Viva; Moss, Nicholas J.; Scheer, Susan

2015-01-01

Background Persons with unsuppressed HIV viral load (VL) who disengage from care may experience poor clinical outcomes and potentially transmit HIV. We assessed the feasibility and yield of using the San Francisco Department of Public Health (SFDPH) enhanced HIV surveillance system (eHARS) to identify and re-engage such persons in care. Methods Using SFDPH eHARS data as of 4/20/2012 (index date), we selected HIV-infected adults who were alive, had no reported VL or CD4 cell count results in the past nine months (proxy for “out-of-care”) and a VL >200 copies/mL drawn nine to 15 months earlier. We prioritized cases residing locally for investigation, and used information from eHARS and medical and public health databases to contact them for interview and referral to the SFDPH linkage services (LINCS). Twelve months later, we matched-back to eHARS data to assess how HIV laboratory reporting delays affected original eligibility, and if persons had any HIV laboratory results performed and reported within 12 months after index date (‘new labs’). Results Among 434 eligible persons, 282 were prioritized for investigation, of whom 75 (27%) were interviewed, 79 (28%) could not be located, and 48 (17%) were located out of the area. Among the interviewed, 54 (72%) persons accepted referral to LINCS. Upon match-back to eHARS data, 324 (75%) in total were confirmed as eligible, including 221 (78%) of the investigated; most had new labs. Conclusions Among the investigated persons presumed out-of-care, we interviewed and offered LINCS referral to about one-quarter, demonstrating the feasibility but limited yield of our project. Matching to updated surveillance data revealed that a substantial minority did not disengage from care and that most re-engaged in HIV care. Verifying persons’ HIV care status with medical providers and improving timeliness of transfer and cross-jurisdictional sharing of HIV laboratory data may aid future efforts. PMID:25748668

Hirshfeld atom refinement.

PubMed

Capelli, Silvia C; Bürgi, Hans-Beat; Dittrich, Birger; Grabowsky, Simon; Jayatilaka, Dylan

2014-09-01

Hirshfeld atom refinement (HAR) is a method which determines structural parameters from single-crystal X-ray diffraction data by using an aspherical atom partitioning of tailor-made ab initio quantum mechanical molecular electron densities without any further approximation. Here the original HAR method is extended by implementing an iterative procedure of successive cycles of electron density calculations, Hirshfeld atom scattering factor calculations and structural least-squares refinements, repeated until convergence. The importance of this iterative procedure is illustrated via the example of crystalline ammonia. The new HAR method is then applied to X-ray diffraction data of the dipeptide Gly-l-Ala measured at 12, 50, 100, 150, 220 and 295 K, using Hartree-Fock and BLYP density functional theory electron densities and three different basis sets. All positions and anisotropic displacement parameters (ADPs) are freely refined without constraints or restraints - even those for hydrogen atoms. The results are systematically compared with those from neutron diffraction experiments at the temperatures 12, 50, 150 and 295 K. Although non-hydrogen-atom ADPs differ by up to three combined standard uncertainties (csu's), all other structural parameters agree within less than 2 csu's. Using our best calculations (BLYP/cc-pVTZ, recommended for organic molecules), the accuracy of determining bond lengths involving hydrogen atoms from HAR is better than 0.009 Å for temperatures of 150 K or below; for hydrogen-atom ADPs it is better than 0.006 Å(2) as judged from the mean absolute X-ray minus neutron differences. These results are among the best ever obtained. Remarkably, the precision of determining bond lengths and ADPs for the hydrogen atoms from the HAR procedure is comparable with that from the neutron measurements - an outcome which is obtained with a routinely achievable resolution of the X-ray data of 0.65 Å.

Hirshfeld atom refinement

PubMed Central

Capelli, Silvia C.; Bürgi, Hans-Beat; Dittrich, Birger; Grabowsky, Simon; Jayatilaka, Dylan

2014-01-01

Hirshfeld atom refinement (HAR) is a method which determines structural parameters from single-crystal X-ray diffraction data by using an aspherical atom partitioning of tailor-made ab initio quantum mechanical molecular electron densities without any further approximation. Here the original HAR method is extended by implementing an iterative procedure of successive cycles of electron density calculations, Hirshfeld atom scattering factor calculations and structural least-squares refinements, repeated until convergence. The importance of this iterative procedure is illustrated via the example of crystalline ammonia. The new HAR method is then applied to X-ray diffraction data of the dipeptide Gly–l-Ala measured at 12, 50, 100, 150, 220 and 295 K, using Hartree–Fock and BLYP density functional theory electron densities and three different basis sets. All positions and anisotropic displacement parameters (ADPs) are freely refined without constraints or restraints – even those for hydrogen atoms. The results are systematically compared with those from neutron diffraction experiments at the temperatures 12, 50, 150 and 295 K. Although non-hydrogen-atom ADPs differ by up to three combined standard uncertainties (csu’s), all other structural parameters agree within less than 2 csu’s. Using our best calculations (BLYP/cc-pVTZ, recommended for organic molecules), the accuracy of determining bond lengths involving hydrogen atoms from HAR is better than 0.009 Å for temperatures of 150 K or below; for hydrogen-atom ADPs it is better than 0.006 Å2 as judged from the mean absolute X-ray minus neutron differences. These results are among the best ever obtained. Remarkably, the precision of determining bond lengths and ADPs for the hydrogen atoms from the HAR procedure is comparable with that from the neutron measurements – an outcome which is obtained with a routinely achievable resolution of the X-ray data of 0.65 Å. PMID:25295177

Effects of adolescent treatment with nicotine, harmane, or norharmane in male Sprague-Dawley rats.

PubMed

Goodwin, Amy K; Lantz-McPeak, Susan M; Robinson, Bonnie L; Law, C Delbert; Ali, Syed F; Ferguson, Sherry A

2015-01-01

The initiation of tobacco use occurs most often in adolescence and may be especially detrimental as the adolescent brain is undergoing substantial development. In addition to nicotine, there are over 9000 other compounds present in tobacco products, including the β-carbolines harmane and norharmane. The present study aimed to determine the long-term effects of adolescent exposure to nicotine (NIC), harmane (HAR), or norharmane (NOR) on locomotor activity, learning and memory, anxiety-like behavior, motor coordination, and monoamine/metabolite concentrations in the striatum and nucleus accumbens of male Sprague-Dawley rats. Beginning on postnatal day (PND) 27 and continuing through PND 55, subjects received twice daily intraperitoneal injections of 1ml/kg saline (CON), 0.5mg NIC/kg, 0.5mg HAR/kg, or 0.5mg NOR/kg. Body weight, food, and water intake were measured daily (PNDs 27-96). Locomotor activity was assessed on PND 40 or 41, PND 55, and PNDs 81 and 82. Other behaviors (anxiety-like behavior, motor coordination, and spatial learning and memory) were assessed at least 25 days after drug exposure ended (PNDs 80-91). On PND 97, subjects were decapitated and the striatum and nucleus accumbens were dissected and frozen for analysis. NIC treatment significantly decreased food intake, but did not alter locomotor activity during or after treatment. HAR and NOR treatment, however, caused significant open field hypoactivity. Motor coordination, water maze performance, and concentrations of monoamines and metabolites in the striatum and nucleus accumbens were unaltered by any drug treatment. These results indicate a long-lasting effect on activity levels from adolescent HAR or NOR treatment; however, there were few long-lasting NIC effects. Given the paucity of data describing effects of HAR or NOR exposure, these data should encourage additional studies of these tobacco constituents as well as constituent combination studies. Published by Elsevier Inc.

SURVIVAL EFFICACY OF THE PEGYLATED G-CSFS MAXY-G34 AND NEULASTA IN A MOUSE MODEL OF LETHAL H-ARS, AND RESIDUAL BONE MARROW DAMAGE IN TREATED SURVIVORS

PubMed Central

Chua, Hui Lin; Plett, P. Artur; Sampson, Carol H.; Katz, Barry P.; Carnathan, Gilbert W.; MacVittie, Thomas J.; Lenden, Keith; Orschell, Christie M.

2013-01-01

In an effort to expand the worldwide pool of available medical countermeasures (MCM) against radiation, the PEGylated G-CSF (PEG-G-CSF) molecules Neulasta and Maxy-G34, a novel PEG-G-CSF designed for increased half-life and enhanced activity compared to Neulasta, were examined in a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS), along with the lead MCM for licensure and stockpiling, G-CSF. Both PEG-G-CSFs were shown to retain significant survival efficacy when administered as a single dose 24hr post-exposure, compared to the 16 daily doses of G-CSF required for survival efficacy. Furthermore, 0.1 mg kg−1 of either PEG-G-CSF effected survival of lethally-irradiated mice that was similar to a 10-fold higher dose. The one dose/low dose administration schedules are attractive attributes of radiation MCM given the logistical challenges of medical care in a mass casualty event. Maxy-G34-treated mice that survived H-ARS were examined for residual bone marrow damage (RBMD) up to 9mo post-exposure. Despite differences in Sca-1 expression and cell cycle position in some hematopoietic progenitor phenotypes, Maxy-G34-treated mice exhibited the same degree of hematopoietic stem cell (HSC) insufficiency as vehicle treated H-ARS survivors in competitive transplantation assays of 150 purified Sca-1+cKit+lin-CD150+ cells. These data suggest that Maxy-G34, at the dose, schedule, and time frame examined, did not mitigate RBMD, but significantly increased survival from H-ARS at one-tenth the dose previously tested, providing strong support for advanced development of Maxy-G34, as well as Neulasta, as MCM against radiation. PMID:24276547

Water for Agriculture in a Vulnerable Delta: A Case Study of Indian Sundarban

NASA Astrophysics Data System (ADS)

Das, S.; Bhadra, T.; Hazra, S.

2015-12-01

Indian Sundarban lies in the south-western part of the Ganges-Brahmaputra Delta and supports a 4.43 million strong population. The agrarian economy of Sundarban is dominated by rainfed subsistence rice farming. Unavailability of upstream fresh water, high salinity of river water of up to 32ppt, soil salinity ranging between 2dSm-1 to 19dSm-1, small land holdings of per capita 840 sq. metre and inadequate irrigation facilities are serious constraints for agricultural production in Sundarban. This paper assesses Cropping Intensity, Irrigation Intensity and Man-Cropland Ratio from Agriculture Census (2010-11) data and estimates the seasonal water demand for agriculture in different blocks of Sundarban. The research exposes the ever increasing population pressure on agriculture with an average Man Cropland Ratio of 1745 person/sq.km. In 2010-2011, the average cropping intensity was 129.97% and the irrigation intensity was 20.40%. The highest cropping and irrigation intensity have been observed in the inland blocks where shallow ground water is available for agriculture on the contrary, the lowest values have been observed in the southern blocks, due to existence of saline shallow ground water. The annual water demand for agriculture in Sundarban has been estimated as 2784 mcm. Available water from 70000 freshwater tanks and around 8000 numbers of shallow tube wells are not sufficient to meet the agricultural water demand. Existing irrigation sources and rainfall of 343 mcm fall far short of the water demand of 382 mcm during peak dry Season. Unavailability of fresh water restricts the food production, which endangers the food security of 87.5% of the people in Sundarban. To ensure the food security in changing climatic condition, expansion of irrigation network and harnessing of new water sources are essential. Large scale rainwater harvesting, rejuvenation and re-connection of disconnected river channels, artificial recharge within shallow aquifer to bring down its salinity can be some of the major policy options to meet the water demand for agriculture in Sundarban.

Distribution features and controls of heavy metals in surface sediments from the riverbed of the Ningxia-Inner Mongolian reaches, Yellow River, China.

PubMed

Guan, Qingyu; Wang, Lei; Pan, Baotian; Guan, Wenqian; Sun, Xiazhong; Cai, Ao

2016-02-01

Fifty-six riverbed surface sediment (RSS) samples were collected along the Ningxia-Inner Mongolian reaches of the Yellow River (NIMYR). These samples were analyzed to determine their heavy metal concentrations (Co, Cr, Ni, Cu, V and Zn), grain sizes, sediment sources and the causes of their heavy metal contamination. The cumulative distribution functions of the heavy metals in RSS of these reaches are plotted to identify the geochemical baseline level (GBL) of each element and determine the average background concentration of each heavy metal. Principal component analysis and hierarchical cluster analysis are conducted based on the grain sizes of RSS, and the samples are classified into two groups: coarse grained samples (CGS) and fine grained samples (FGS). The degree of heavy metal contamination for each sample is identified by its enrichment factor (EF). The results reveal that the coarse particle component (medium sand and coarse sand) in the bed materials is chiefly from the bordering deserts along the Yellow River. The clay and silt in the bed materials chiefly originate from the upper reaches of the Yellow River, and the fine sand is identified as a hybrid sediment derived from the upper reaches of the Yellow River and the bordering deserts. The CGS primarily appear in the reaches bordering deserts, and the sites are near the confluence of gullies and the Yellow River. The FGS are located adjacent to cities with especially strong industrial activity such as Wuhai, Bayan Nur, Baotou and Togtoh. The Cr, Ni, Cu, V and Zn concentrations (mg kg(-1)) are 84.34 ± 49.46, 30.21 ± 7.90, 25.01 ± 7.61, 73.17 ± 18.92 and 55.62 ± 18.93 in the FGS and 65.07 ± 19.51, 23.86 ± 6.84, 18.04 ± 3.8, 53.47 ± 10.57 and 34.89 ± 9.19 in the CGS respectively, and the concentrations of Co in the CGS (213.40 ± 69.71) are notably higher than in the FGS (112.02 ± 48.87) and greater than the Co GBL (210). The most contaminated samples in the NIMYR are adjacent to the cities of Wuhai (EF(Cr) = 5.19; EF(Ni) = 1.96), Bayan Nur (EF(Cr) = 5.88; EF(Ni )= 2.08) and Baotou (EF(Cu) = 1.55; EF(Zn) = 1.68) where the Cr, Ni, Cu, V and Zn concentrations are above the correlated GBLs (85, 34, 27, 75 and 62 mg kg(-1), respectively), which are mostly affected by industrial processes, and samples that are only moderately contaminated by heavy metals are found in the reaches bordering desert (Wuhai-Baotou) because contaminated sediments are diluted by uncontaminated desert sand. In contrast, all of the Cu, Cr, Ni, V and Zn concentrations in RSS of the Qingtongxia-Wuhai reach are lower than the correlated GBLs of elements. Copyright © 2015 Elsevier Ltd. All rights reserved.

Leverage effect, economic policy uncertainty and realized volatility with regime switching

NASA Astrophysics Data System (ADS)

Duan, Yinying; Chen, Wang; Zeng, Qing; Liu, Zhicao

2018-03-01

In this study, we first investigate the impacts of leverage effect and economic policy uncertainty (EPU) on future volatility in the framework of regime switching. Out-of-sample results show that the HAR-RV including the leverage effect and economic policy uncertainty with regimes can achieve higher forecast accuracy than RV-type and GARCH-class models. Our robustness results further imply that these factors in the framework of regime switching can substantially improve the HAR-RV's forecast performance.

The relevance of netnography to the harness of Romanian health care electronic word-of-mouth.

PubMed

Bratucu, R; Gheorghe, I R; Radu, A; Purcarea, V L

2014-09-15

Nowadays, consumers use the computer mediated communication to make purchase decisions on a large variety of products and services. Since health care services are archetypal by nature, consumers in this field are one of the most encountered users of electronic word-of-mouth. The objective of this paper is to explain and support the necessity of adopting a different qualitative method when electronic word of mouth is harnessed on health care dedicated forums, that is, netnography.

The relevance of netnography to the harness of Romanian health care electronic word-of-mouth

PubMed Central

Bratucu, R; Gheorghe, IR; Radu, A; Purcarea, VL

2014-01-01

Abstract Nowadays, consumers use the computer mediated communication to make purchase decisions on a large variety of products and services. Since health care services are archetypal by nature, consumers in this field are one of the most encountered users of electronic word-of-mouth. The objective of this paper is to explain and support the necessity of adopting a different qualitative method when electronic word of mouth is harnessed on health care dedicated forums, that is, netnography. PMID:25408755

ASCAN Helms with instructor during Elgin AFB water survival training

NASA Technical Reports Server (NTRS)

1990-01-01

1990 Group 13 Astronaut Candidate (ASCAN) Susan J. Helms, wearing helmet with oxygen mask and inflated life jacket, is assisted by training instructor during water survival exercises at Elgin Air Force Base (AFB) in Pensacola, Florida. Helms looks on as the instructor adjusts her parachute harness. When ready, Helms will be dropped from the harness into the pool (in background) to simulate a water landing after T-38 ejection. ASCANs participated in the exercises from 08-14-90 through 08-17-90.

ASCAN Helms with instructor during Elgin AFB water survival training

NASA Image and Video Library

1990-09-20

1990 Group 13 Astronaut Candidate (ASCAN) Susan J. Helms, wearing helmet with oxygen mask and inflated life jacket, is assisted by training instructor during water survival exercises at Elgin Air Force Base (AFB) in Pensacola, Florida. Helms looks on as the instructor adjusts her parachute harness. When ready, Helms will be dropped from the harness into the pool (in background) to simulate a water landing after T-38 ejection. ASCANs participated in the exercises from 08-14-90 through 08-17-90.

Filter line wiring designs in aircraft

NASA Astrophysics Data System (ADS)

Rowe, Richard M.

1990-10-01

The paper presents a harness design using a filter-line wire technology and appropriate termination methods to help meet high-energy radiated electromagnetic field (HERF) requirements for protection against the adverse effects of EMI on electrical and avionic systems. Filter-line interconnect harnessing systems discussed consist of high-performance wires and cables; when properly wired they suppress conducted and radiated EMI above 100 MHz. Filter-line termination devices include backshell adapters, braid splicers, and shield terminators providing 360-degree low-impedance terminations and enhancing maintainability of the system.

Advances in immunotherapeutic strategies for colorectal cancer commentary on: tumoral immune cell exploitation in colorectal cancer metastases can be targeted effectively by anti-CCR5 therapy in cancer patients by Halama et al.

PubMed

Deming, Dustin A

2016-01-01

Colorectal cancer is a leading cause of cancer-related death in the United States, despite recent advances in treatment strategies. The immune system has been implicated in the pathogenesis of colorectal cancer, with numerous studies identifying either antagonistic or pro-tumorigenic effects of infiltrating immune cells. Therapeutic strategies harnessing the immune system to target cancers have evolved expediently over the last 5 years, especially the use of checkpoint inhibitors. Recently, a subset of patients whose colorectal cancers harbor a deficiency in mismatch repair proteins have demonstrated dramatic and durable response to checkpoint blockade. Unfortunately, the vast majority of colorectal cancers are mismatch repair proficient and resistant to these inhibitors. The tumor microenvironment has been implicated in the resistance to checkpoint block and ways to overcome these resistance mechanisms would be a major advance for the treatment of colorectal cancer. Here we provide commentary on a manuscript from Halama et al. examining CCL5/CCR5 as an immune biomarker and the potential role of anti-CCR5 agents for the treatment of patients with colorectal cancer.

Self-assembled micro-organogels for 3D printing silicone structures.

PubMed

O'Bryan, Christopher S; Bhattacharjee, Tapomoy; Hart, Samuel; Kabb, Christopher P; Schulze, Kyle D; Chilakala, Indrasena; Sumerlin, Brent S; Sawyer, W Gregory; Angelini, Thomas E

2017-05-01

The widespread prevalence of commercial products made from microgels illustrates the immense practical value of harnessing the jamming transition; there are countless ways to use soft, solid materials that fluidize and become solid again with small variations in applied stress. The traditional routes of microgel synthesis produce materials that predominantly swell in aqueous solvents or, less often, in aggressive organic solvents, constraining ways that these exceptionally useful materials can be used. For example, aqueous microgels have been used as the foundation of three-dimensional (3D) bioprinting applications, yet the incompatibility of available microgels with nonpolar liquids, such as oils, limits their use in 3D printing with oil-based materials, such as silicone. We present a method to make micro-organogels swollen in mineral oil, using block copolymer self-assembly. The rheological properties of this micro-organogel material can be tuned, leveraging the jamming transition to facilitate its use in 3D printing of silicone structures. We find that the minimum printed feature size can be controlled by the yield stress of the micro-organogel medium, enabling the fabrication of numerous complex silicone structures, including branched perfusable networks and functional fluid pumps.

The Banana Genome Hub

PubMed Central

Droc, Gaëtan; Larivière, Delphine; Guignon, Valentin; Yahiaoui, Nabila; This, Dominique; Garsmeur, Olivier; Dereeper, Alexis; Hamelin, Chantal; Argout, Xavier; Dufayard, Jean-François; Lengelle, Juliette; Baurens, Franc-Christophe; Cenci, Alberto; Pitollat, Bertrand; D’Hont, Angélique; Ruiz, Manuel; Rouard, Mathieu; Bocs, Stéphanie

2013-01-01

Banana is one of the world’s favorite fruits and one of the most important crops for developing countries. The banana reference genome sequence (Musa acuminata) was recently released. Given the taxonomic position of Musa, the completed genomic sequence has particular comparative value to provide fresh insights about the evolution of the monocotyledons. The study of the banana genome has been enhanced by a number of tools and resources that allows harnessing its sequence. First, we set up essential tools such as a Community Annotation System, phylogenomics resources and metabolic pathways. Then, to support post-genomic efforts, we improved banana existing systems (e.g. web front end, query builder), we integrated available Musa data into generic systems (e.g. markers and genetic maps, synteny blocks), we have made interoperable with the banana hub, other existing systems containing Musa data (e.g. transcriptomics, rice reference genome, workflow manager) and finally, we generated new results from sequence analyses (e.g. SNP and polymorphism analysis). Several uses cases illustrate how the Banana Genome Hub can be used to study gene families. Overall, with this collaborative effort, we discuss the importance of the interoperability toward data integration between existing information systems. Database URL: http://banana-genome.cirad.fr/ PMID:23707967

Self-assembled micro-organogels for 3D printing silicone structures

PubMed Central

O’Bryan, Christopher S.; Bhattacharjee, Tapomoy; Hart, Samuel; Kabb, Christopher P.; Schulze, Kyle D.; Chilakala, Indrasena; Sumerlin, Brent S.; Sawyer, W. Gregory; Angelini, Thomas E.

2017-01-01

The widespread prevalence of commercial products made from microgels illustrates the immense practical value of harnessing the jamming transition; there are countless ways to use soft, solid materials that fluidize and become solid again with small variations in applied stress. The traditional routes of microgel synthesis produce materials that predominantly swell in aqueous solvents or, less often, in aggressive organic solvents, constraining ways that these exceptionally useful materials can be used. For example, aqueous microgels have been used as the foundation of three-dimensional (3D) bioprinting applications, yet the incompatibility of available microgels with nonpolar liquids, such as oils, limits their use in 3D printing with oil-based materials, such as silicone. We present a method to make micro-organogels swollen in mineral oil, using block copolymer self-assembly. The rheological properties of this micro-organogel material can be tuned, leveraging the jamming transition to facilitate its use in 3D printing of silicone structures. We find that the minimum printed feature size can be controlled by the yield stress of the micro-organogel medium, enabling the fabrication of numerous complex silicone structures, including branched perfusable networks and functional fluid pumps. PMID:28508071

Use of Lentiviral Particles As a Cell Membrane-Based mFasL Delivery System for In Vivo Treatment of Inflammatory Arthritis.

PubMed

Rodríguez-Frade, José M; Guedán, Anabel; Lucas, Pilar; Martínez-Muñoz, Laura; Villares, Ricardo; Criado, Gabriel; Balomenos, Dimitri; Reyburn, Hugh T; Mellado, Mario

2017-01-01

During budding, lentiviral particles (LVP) incorporate cell membrane proteins in the viral envelope. We explored the possibility of harnessing this process to generate LVP-expressing membrane proteins of therapeutic interest and studied the potential of these tools to treat different pathologies. Fas-mediated apoptosis is central to the maintenance of T cell homeostasis and prevention of autoimmune processes. We prepared LVP that express murine FasL on their surface. Our data indicate that mFasL-bearing LVP induce caspase 3 and 9 processing, cytochrome C release, and significantly more cell death than control LVP in vitro . This cytotoxicity is blocked by the caspase inhibitor Z-VAD. Analysis of the application of these reagents for the treatment of inflammatory arthritis in vivo suggests that FasL-expressing LVP could be useful for therapy in autoimmune diseases such as rheumatoid arthritis, where there is an excess of Fas-expressing activated T cells in the joint. LVP could be a vehicle not only for mFasL but also for other membrane-bound proteins that maintain their native conformation and might mediate biological activities.

Exploitation of necroptosis for treatment of caspase-compromised cancers.

PubMed

Cho, Young Sik; Park, Hey Li

2017-08-01

Programmed necrosis, or necroptosis, is a type of specialized cell death with necrotic characteristics, including the loss of membrane integrity and swollen organelles in dying cells. However, unlike simple necrosis, it may be induced as an alternative form of cell death when apoptosis is blocked and it is mediated in an orchestrated manner, similar to apoptosis, by a series of signaling molecules. Necroptosis-associated proteins and their specific small molecules have been extensively identified in order to illuminate the underlying mechanisms by which necroptosis is activated through a novel signaling pathway. However, the biological significance of necroptosis, which is known as a secondary route of apoptosis, remains under debate. Concurrent with these concerns, the clinical application of necroptosis has been cautiously proposed to treat necroptosis-associated diseases, and to overcome resistance to anticancer drugs. Accordingly, the present review will highlight the harnessing of necroptosis for anticancer therapy. To this end, the state-of-the art technique of necroptosis as a cancer therapy will be briefly described, and then its potential for clinical purposes will be delineated. For a further understanding of necroptosis, the present review begins with a basic introduction to necroptosis and its multifaceted physiological consequences.

Exploitation of necroptosis for treatment of caspase-compromised cancers

PubMed Central

Cho, Young Sik; Park, Hey Li

2017-01-01

Programmed necrosis, or necroptosis, is a type of specialized cell death with necrotic characteristics, including the loss of membrane integrity and swollen organelles in dying cells. However, unlike simple necrosis, it may be induced as an alternative form of cell death when apoptosis is blocked and it is mediated in an orchestrated manner, similar to apoptosis, by a series of signaling molecules. Necroptosis-associated proteins and their specific small molecules have been extensively identified in order to illuminate the underlying mechanisms by which necroptosis is activated through a novel signaling pathway. However, the biological significance of necroptosis, which is known as a secondary route of apoptosis, remains under debate. Concurrent with these concerns, the clinical application of necroptosis has been cautiously proposed to treat necroptosis-associated diseases, and to overcome resistance to anticancer drugs. Accordingly, the present review will highlight the harnessing of necroptosis for anticancer therapy. To this end, the state-of-the art technique of necroptosis as a cancer therapy will be briefly described, and then its potential for clinical purposes will be delineated. For a further understanding of necroptosis, the present review begins with a basic introduction to necroptosis and its multifaceted physiological consequences. PMID:28789335

Heterogeneous autoregressive model with structural break using nearest neighbor truncation volatility estimators for DAX.

PubMed

Chin, Wen Cheong; Lee, Min Cherng; Yap, Grace Lee Ching

2016-01-01

High frequency financial data modelling has become one of the important research areas in the field of financial econometrics. However, the possible structural break in volatile financial time series often trigger inconsistency issue in volatility estimation. In this study, we propose a structural break heavy-tailed heterogeneous autoregressive (HAR) volatility econometric model with the enhancement of jump-robust estimators. The breakpoints in the volatility are captured by dummy variables after the detection by Bai-Perron sequential multi breakpoints procedure. In order to further deal with possible abrupt jump in the volatility, the jump-robust volatility estimators are composed by using the nearest neighbor truncation approach, namely the minimum and median realized volatility. Under the structural break improvements in both the models and volatility estimators, the empirical findings show that the modified HAR model provides the best performing in-sample and out-of-sample forecast evaluations as compared with the standard HAR models. Accurate volatility forecasts have direct influential to the application of risk management and investment portfolio analysis.

Human Activity Recognition by Combining a Small Number of Classifiers.

PubMed

Nazabal, Alfredo; Garcia-Moreno, Pablo; Artes-Rodriguez, Antonio; Ghahramani, Zoubin

2016-09-01

We consider the problem of daily human activity recognition (HAR) using multiple wireless inertial sensors, and specifically, HAR systems with a very low number of sensors, each one providing an estimation of the performed activities. We propose new Bayesian models to combine the output of the sensors. The models are based on a soft outputs combination of individual classifiers to deal with the small number of sensors. We also incorporate the dynamic nature of human activities as a first-order homogeneous Markov chain. We develop both inductive and transductive inference methods for each model to be employed in supervised and semisupervised situations, respectively. Using different real HAR databases, we compare our classifiers combination models against a single classifier that employs all the signals from the sensors. Our models exhibit consistently a reduction of the error rate and an increase of robustness against sensor failures. Our models also outperform other classifiers combination models that do not consider soft outputs and an Markovian structure of the human activities.

Concept of internal structural controls for evaluation of inactive synthetic peptide analogs: synthesis of [Orn13,14]apamin and its guanidination to an apamin derivative with full neurotoxic activity.

PubMed Central

Cosand, W L; Merrifield, R B

1977-01-01

The importance of arginine residues 13 and 14 in the bee venom neurotoxin, apamin, was teste by the synthesis of replacement analogs. [13,14-di-Ndelta-trifluoroacetylornithine]Apamin was synthesized by the solid phase method on a benzhydrylamine resin. It was deprotected to [13,14-diornithine]apamin, which was then guanidinated to produce the 4-homoarginine-13,14-diarginine analog, [Har4]apamin. Neither the trifluoroacetylornithine analog nor the ornithine analog produced any detectable symptoms when injected intravenously into mice. However, the synthetic [Har4]apamin exhibited the full neurotoxic activity of native apamin and of [Har4]apamin derived from the natural toxin. This provided an internal structural control for the correctness of the primary structure of the inactive synthetic analogs and strengthened the conclusion that one, or both, of the arginine residues plays an important role in the action of apamin. Images PMID:268626

Hydrodynamic modeling and feasibility study of harnessing tidal power at the Bay of Fundy

NASA Astrophysics Data System (ADS)

Chang, Jen

Due to rising fuel costs and environmental concerns, energy generation from alternative power source has become one of the most important issues in energy policy. Tidal power is one of the alternative energy sources. The tidal range at the Bay of Fundy is the largest in the world (approximately 16 meters). It represents a prime location for harnessing tidal power using the daily rising and ebbing tide. In this study, a two dimensional finite element model has been developed and applied to simulate the tidal responses, including water level and flow velocity, in the Bay of Fundy region. The simulation results are used to choose the suitable location for energy development and to predict possible energy generated from different types of generation methods. Fluid motion is assumed to be governed by the shallow water equation since the wave length associated with tide is much longer than the water depth in the Bay of Fundy. By using a real time series of water elevation at the entrance of the bay, the computer model finds tidal response for each node in the study area, which is then verified by the observation record from several tidal gauge stations inside the bay. This study shows that the at-site cost of the energy for barrage type tidal power plants is around 0.065 to 0.097 per kWh at the recommended Shepody Bay, Cumberland Basin, and Cobequid Bay. The cost of energy for the current turbine type tidal power plants is 0.13/kWh to 0.24/kWh at the area with highest current velocity. Compared with the recent bill of the local power company, the at-site unit cost of energy from the barrage type of tidal power plant is feasible, but the environmental concerns of channel blocking by barrage present a formidable constraint. For the current turbine type of tidal power plant, even the most suitable sites are not financially feasible under current technology, but this type of power generation may become feasible as oil prices continue to increase and more efficient turbines become available.

Network harness: bundles of routes in public transport networks

NASA Astrophysics Data System (ADS)

Berche, B.; von Ferber, C.; Holovatch, T.

2009-12-01

Public transport routes sharing the same grid of streets and tracks are often found to proceed in parallel along shorter or longer sequences of stations. Similar phenomena are observed in other networks built with space consuming links such as cables, vessels, pipes, neurons, etc. In the case of public transport networks (PTNs) this behavior may be easily worked out on the basis of sequences of stations serviced by each route. To quantify this behavior we use the recently introduced notion of network harness. It is described by the harness distribution P(r, s): the number of sequences of s consecutive stations that are serviced by r parallel routes. For certain PTNs that we have analyzed we observe that the harness distribution may be described by power laws. These power laws indicate a certain level of organization and planning which may be driven by the need to minimize the costs of infrastructure and secondly by the fact that points of interest tend to be clustered in certain locations of a city. This effect may be seen as a result of the strong interdependence of the evolutions of both the city and its PTN. To further investigate the significance of the empirical results we have studied one- and two-dimensional models of randomly placed routes modeled by different types of walks. While in one dimension an analytic treatment was successful, the two dimensional case was studied by simulations showing that the empirical results for real PTNs deviate significantly from those expected for randomly placed routes.

Induced compression wood formation in Douglas fir (Pseudotsuga menziesii) in microgravity

NASA Technical Reports Server (NTRS)

Kwon, M.; Bedgar, D. L.; Piastuch, W.; Davin, L. B.; Lewis, N. G.

2001-01-01

In the microgravity environment of the Space Shuttle Columbia (Life and Microgravity Mission STS-78), were grown 1-year-old Douglas fir and loblolly pine plants in a NASA plant growth facility. Several plants were harnessed (at 45 degrees ) to establish if compression wood biosynthesis, involving altered cellulose and lignin deposition and cell wall structure would occur under those conditions of induced mechanical stress. Selected plants were harnessed at day 2 in orbit, with stem sections of specific plants harvested and fixed for subsequent microscopic analyses on days 8, 10 and 15. At the end of the total space mission period (17 days), the remaining healthy harnessed plants and their vertical (upright) controls were harvested and fixed on earth. All harnessed (at 45 degrees ) plant specimens, whether grown at 1 g or in microgravity, formed compression wood. Moreover, not only the cambial cells but also the developing tracheid cells underwent significant morphological changes. This indicated that the developing tracheids from the primary cell wall expansion stage to the fully lignified maturation stage are involved in the perception and transduction of the stimuli stipulating the need for alteration of cell wall architecture. It is thus apparent that, even in a microgravity environment, woody plants can make appropriate corrections to compensate for stress gradients introduced by mechanical bending, thereby enabling compression wood to be formed. The evolutionary implications of these findings are discussed in terms of "variability" in cell wall biosynthesis.

Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS)

NASA Astrophysics Data System (ADS)

Harper, Conner C.; Elliott, Andrew G.; Lin, Haw-Wei; Williams, Evan R.

2018-06-01

A general method for in situ measurements of the energy of individual ions trapped and weighed using charge detection mass spectrometry (CDMS) is described. Highly charged (> 300 e), individual polyethylene glycol (PEG) ions are trapped and oscillate within an electrostatic trap, producing a time domain signal. A segmented Fourier transform (FT) of this signal yields the temporal evolution of the fundamental and harmonic frequencies of ion motion throughout the 500-ms trap time. The ratio of the fundamental frequency and second harmonic (HAR) depends on the ion energy, which is an essential parameter for measuring ion mass in CDMS. This relationship is calibrated using simulated ion signals, and the calibration is compared to the HAR values measured for PEG ion signals where the ion energy was also determined using an independent method that requires that the ions be highly charged (> 300 e). The mean error of 0.6% between the two measurements indicates that the HAR method is an accurate means of ion energy determination that does not depend on ion size or charge. The HAR is determined dynamically over the entire trapping period, making it possible to observe the change in ion energy that takes place as solvent evaporates from the ion and collisions with background gas occur. This method makes it possible to measure mass changes, either from solvent evaporation or from molecular fragmentation (MSn), as well as the cross sections of ions measured using CDMS.

The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: a prospective study.

PubMed

Cicek, Ismet Esra; Cicek, Erdinc; Kayhan, Fatih; Uguz, Faruk; Erayman, Ibrahim; Kurban, Sevil; Yerlikaya, F Hümeyra; Kaya, Nazmiye

2014-03-01

The aim of the study was to research the relationship between interferon (IFN) induced depression and sociodemographic characteristics, neurotrophic factors and oxidative stress. Sixty four cases, 34 with Chronic Hepatitis B (CHB) and 30 with Chronic Hepatitis C (CHC), were included in the study. The patients were assessed with Structured Clinical Interview for DSM-IV (SCID-I), Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS) at baseline on the 2nd and 6th weeks of treatment. S100 calcium binding protein B (S100B), brain-derived neurotrophic factor (BDNF), total antioxidant status (TAS) and total oxidative stress (TOS) levels were measured at the same visits. In total, 20 patients were diagnosed with major depression (MD) on the sixth week. A significant relationship was found between depression developed after IFN therapy and baseline HARS scores and the type of IFN-α. When the pretreatment levels of HDRS, HARS, S100B, BDNF, TAS, and TOS were compared to those after treatment on the 2nd week, there was a significant increase in HDRS and HARS levels and a significant decrease in the levels of S100B and BDNF. No significant change was determined for TAS and TOS levels. Our study suggests that the pathogenesis of IFN induced depression may involve neurotrophic factors. Copyright © 2014 Elsevier Inc. All rights reserved.

Uneven drive rates of the scanning telescope: Apollo 16 mission

NASA Technical Reports Server (NTRS)

1972-01-01

An investigation was made into the cause or causes of uneven drive rates during operation of the Apollo 16 scanning telescope. It was suggested that such erratic behavior was caused by either changes in the characteristics noise level of the optics counter on the panels or the repositioning process by the computer or zero optics mode. Test results show the anomaly was not caused by either of the above suggestions, instead they were caused by a broken socket spring in the telescope harness. New harnesses will be manufactured for future flights.

Restraint harness performance during flight maneuvers: a parametric study.

PubMed

Du, Cheng-Fei; Liu, Xiao-Yu; Wang, Li-Zhen; Liu, Song-Yang; Fan, Yu-Bo

2015-05-01

Modern super agile fighter aircraft are capable of producing an increasing multiaxial acceleration environment which can adversely affect the pilot. An evaluation of the performance of the restraint system during flight maneuvers will benefit restraint designs and, thus, the safety of pilots. A finite element model of a mannequin with PCU-15/P harness restraint was used in this study to investigate how the factors, such as strap material stiffness, friction, and belt tension, affect the performance of restraint systems during impact along the -Gx, -Gy, and -Gz directions. The corresponding maximum displacement of the mannequin's torso was computed. The mannequin moved beyond 74 mm sideways. The change in friction coefficient (FC) from 0.1 to 0.4 decreased the displacement of the lower torso by less than 6.7%. The displacement of the torso decreased as the stiffness of the strap or tension increased. Displacement decreased by 9.3%, 6.0%, and 2.7% for the lower torso under the Gx impact, as the tightening force increased from 20 N to 80 N gradually. However, this changed slightly when the stiffness arrived at 1 E or the tension increased to 60 N. PCU-15/P harness has the poorest performance during side impact and friction plays an unimportant role in affecting its performance. The stiffness of the webbing used in the PCU-15/P harness is sufficiently high. The lap belt has more effect on limiting the movement of the pilot than the shoulder straps, and a tension of 60 N during the adjustment may be enough for conventional flight maneuvers.

Developmental dysplasia of the hip in the newborn: A systematic review

PubMed Central

Gulati, Vivek; Eseonu, Kelechi; Sayani, Junaid; Ismail, Nizar; Uzoigwe, Chika; Choudhury, Muhammed Zaki; Gulati, Pooja; Aqil, Adeel; Tibrewal, Saket

2013-01-01

Developmental dysplasia of the hip (DDH) denotes a wide spectrum of conditions ranging from subtle acetabular dysplasia to irreducible hip dislocations. Clinical diagnostic tests complement ultrasound imaging in allowing diagnosis, classification and monitoring of this condition. Classification systems relate to the alpha and beta angles in addition to the dynamic coverage index (DCI). Screening programmes for DDH show considerable geographic variation; certain risk factors have been identified which necessitate ultrasound assessment of the newborn. The treatment of DDH has undergone significant evolution, but the current gold standard is still the Pavlik harness. Duration of Pavlik harness treatment has been reported to range from 3 to 9.3 mo. The beta angle, DCI and the superior/lateral femoral head displacement can be assessed via ultrasound to estimate the likelihood of success. Success rates of between 7% and 99% have been reported when using the harness to treat DDH. Avascular necrosis remains the most devastating complication of harness usage with a reported rate of between 0% and 28%. Alternative non-surgical treatment methods used for DDH include devices proposed by LeDamany, Frejka, Lorenz and Ortolani. The Rosen splint and Wagner stocking have also been used for DDH treatment. Surgical treatment for DDH comprises open reduction alongside a combination of femoral or pelvic osteotomies. Femoral osteotomies are carried out in cases of excessive anteversion or valgus deformity of the femoral neck. The two principal pelvic osteotomies most commonly performed are the Salter osteotomy and Pemberton acetabuloplasty. Serious surgical complications include epiphyseal damage, sciatic nerve damage and femoral neck fracture. PMID:23610749

Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS).

PubMed

Harper, Conner C; Elliott, Andrew G; Lin, Haw-Wei; Williams, Evan R

2018-06-02

A general method for in situ measurements of the energy of individual ions trapped and weighed using charge detection mass spectrometry (CDMS) is described. Highly charged (> 300 e), individual polyethylene glycol (PEG) ions are trapped and oscillate within an electrostatic trap, producing a time domain signal. A segmented Fourier transform (FT) of this signal yields the temporal evolution of the fundamental and harmonic frequencies of ion motion throughout the 500-ms trap time. The ratio of the fundamental frequency and second harmonic (HAR) depends on the ion energy, which is an essential parameter for measuring ion mass in CDMS. This relationship is calibrated using simulated ion signals, and the calibration is compared to the HAR values measured for PEG ion signals where the ion energy was also determined using an independent method that requires that the ions be highly charged (> 300 e). The mean error of 0.6% between the two measurements indicates that the HAR method is an accurate means of ion energy determination that does not depend on ion size or charge. The HAR is determined dynamically over the entire trapping period, making it possible to observe the change in ion energy that takes place as solvent evaporates from the ion and collisions with background gas occur. This method makes it possible to measure mass changes, either from solvent evaporation or from molecular fragmentation (MS n ), as well as the cross sections of ions measured using CDMS. Graphical Abstract.

Carbothermic reduction behaviors of Ti-Nb-bearing Fe concentrate from Bayan Obo ore in China

NASA Astrophysics Data System (ADS)

Wang, Guang; Du, Ya-xing; Wang, Jing-song; Xue, Qing-guo

2018-01-01

To support the development of technology to utilize low-grade Ti-Nb-bearing Fe concentrate, the reduction of the concentrate by coal was systematically investigated in the present paper. A liquid phase formed when the Ti-Nb-bearing Fe concentrate/coal composite pellet was reduced at temperatures greater than 1100°C. The addition of CaCO3 improved the reduction rate when the slag basicity was less than 1.0 and inhibited the formation of the liquid phase. Mechanical milling obviously increased the metallization degree compared with that of the standard pellet when reduced under the same conditions. Evolution of the mineral phase composition and microstructure of the reduced Ti-Nb-bearing Fe concentrate/coal composite pellet at 1100°C were analyzed by X-ray diffraction and scanning electron microscopy-energy-dispersive spectroscopy. The volume shrinkage value of the reduced Ti-Nb-bearing Fe concentrate/coal composite pellet with a basicity of 1.0 was approximately 35.2% when the pellet was reduced at 1100°C for 20 min, which enhanced the external heat transfer to the lower layers when reduced in a practical rotary hearth furnace. The present work provides key parameters and mechanism understanding for the development of carbothermic reduction technology of a Ti-Nb-bearing Fe concentrate incorporated in a pyrometallurgical utilization flow sheet.

Fabrication of high aspect ratio structure and its releasing for silicon on insulator MEMS/MOEMS device application

NASA Astrophysics Data System (ADS)

Fan, Ji; Zhang, Wen Ting; Liu, Jin Quan; Wu, Wen Jie; Zhu, Tao; Tu, Liang Cheng

2015-04-01

We systematically investigate the fabrication and dry-release technology for a high aspect ratio (HAR) structure with vertical and smooth silicon etching sidewalls. One-hundred-micrometer silicon on insulator (SOI) wafers are used in this work. By optimizing the process parameters of inductively coupled plasma deep reactive-ion etching, a HAR (˜25∶1) structure with a microtrench width of 4 μm has been demonstrated. A perfect etching profile has been obtained in which the structures present an almost perfect verticality of 0.10 μm and no sidewall scallops. The root-mean square roughness of silicon sidewalls is 20 to 29 nm. An in situ dry-release method using notching effect is employed after etching. By analysis, we found that the final notch length is typically an aspect-ratio-dependent process. The structure designed in this work has been successfully released by this in situ dry-release method, and the released bottom roughness effectively prohibits the stiction mechanism. The results demonstrate potential applications for design and fabrication of HAR SOI MEMS/MOEMS.

New Padded Harness for Self-Acquisition of Resting 12-Lead ECGs

NASA Technical Reports Server (NTRS)

Schlegel, T. T.; Rood, A. T.

2011-01-01

We have developed a dry-electrode harness that permits easy, rapid, and unsupervised self-acquisition of resting 12-lead ECGs without the use of any disposables. Various other advantageous features of the harness include: 1) padded or inflatable cushions at the lateral sides of the torso that function to press the left arm (LA) and right arm (RA) dry electrodes mounted on cushions against sideward (as shown in the Figure below) or downward-rested arms of the subject; 2) sufficient distal placement of the arm electrodes with good abutment and without the need for adhesives, straps, bands, bracelets, or gloves on the arms; 3) padding over the sternum to avoid "tenting" in the V1 through V3 (and V3R, when present) electrode positions; 4) easy-to-don, one-piece design with an adjustable single point of connection and an adjustable shoulder strap; and 5) Lund or "modified Lund" placement of the dry electrodes, the results of which more effectively reproduce results from "standard" 12-lead ECG placements than do results from Mason-Likar lead placements.

Development of an ethanol model using social insects: IV. Influence of ethanol on the aggression of Africanized honey bees (Apis mellifera L.).

PubMed

Abramson, Charles I; Place, Aaron J; Aquino, Italo S; Fernandez, Andrea

2004-06-01

Experiments were designed to determine whether ethanol influenced aggression in honey bees. Two experiments are reported. In Exp. 1, harnessed honey bees were fed a 1%, 5%, 10%, or 20% ethanol solution. Two control groups received either a sucrose solution only or no pretreatment, respectively. The dependent variable was the number of sting extensions over 10 min. Analysis showed that aggression in harnessed bees was not influenced by prior ethanol consumption. Because there was some suspicion that the extension of the sting apparatus may be hindered by harnessing, and the authors wanted to use a design that increased ecological validity, Exp. 2 was conducted with free-flying bees. Sucrose or 20% ethanol solutions were placed in front of beehives, and the number of stings on a leather patch dangled in front of the hive served as the dependent variable. The experiment was terminated after 5 hr. because bees exposed to ethanol became dangerously aggressive. A unique aspect of the study was that Africanized honey bees were used.

vvtools v. 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drake, Richard R.

Vvtools is a suite of testing tools, with a focus on reproducible verification and validation. They are written in pure Python, and contain a test harness and an automated process management tool. Users of vvtools can develop suites of verification and validation tests and run them on small to large high performance computing resources in an automated and reproducible way. The test harness enables complex processes to be performed in each test and even supports a one-level parent/child dependency between tests. It includes a built in capability to manage workloads requiring multiple processors and platforms that use batch queueing systems.

Techniques and instrumentation effort for whale migration tracking

NASA Technical Reports Server (NTRS)

Goodman, R. M.; Norris, K. S.; Hobbs, L.; Gibson, R. J.; Dougherty, E.; Palladino, J.

1975-01-01

The following aspects of a research program concerned with tracking gray whales were documented: (1) design, fabrication and testing of a girdle-type harness and associated gear (release mechanism, tracking transmitter, xenon flasher), (2) design, fabrication and testing of instrumentation packs (subminiature recorder, sensor, electronics), (3) field preparations for the January-February 1974 expedition off Mexico, (4) travel arrangements, (5) preliminary field report (capture and handling of juvenile whales, instrumentation and housing tests, harness abrasion and chafing, respiration measurements, sea tracking, distribution, number, and behavior of whales at Lopez Mateos), (6) review, data reduction, and analysis of results.

KENNEDY SPACE CENTER, FLA. - Jeff Thon, an SRB mechanic with United Space Alliance, is fitted with a harness to test a vertical solid rocket booster propellant grain inspection technique. Thon will be lowered inside a mockup of two segments of the SRBs. The inspection of segments is required as part of safety analysis.

NASA Image and Video Library

2003-09-11

KENNEDY SPACE CENTER, FLA. - Jeff Thon, an SRB mechanic with United Space Alliance, is fitted with a harness to test a vertical solid rocket booster propellant grain inspection technique. Thon will be lowered inside a mockup of two segments of the SRBs. The inspection of segments is required as part of safety analysis.

KSC-07pd2606

NASA Image and Video Library

2007-09-28

KENNEDY SPACE CENTER, FLA. -- Astronaut Leopold Eyharts, who represents the European Space Agency, tries on a harness in the Orbiter Processing Facility. Eyharts will be traveling to the International Space Station to join the Expedition 16 crew as a flight engineer. The crew is at Kennedy to take part in a crew equipment interface test, or CEIT, which helps familiarize them with equipment and payloads for the mission. Among the activities standard to a CEIT are harness training, inspection of the thermal protection system and camera operation for planned extravehicular activities, or EVAs. STS-122 is targeted for launch in December. Photo credit: NASA/Kim Shiflett

KSC-07pd2605

NASA Image and Video Library

2007-09-28

KENNEDY SPACE CENTER, FLA. -- Members of the STS-122 crew take part in harness training in the Orbiter Processing Facility at NASA's Kennedy Space Center. Seen from left are Mission Specialists Stanley Love and Leland Melvin and Pilot Alan Poindexter. The crew is at Kennedy to take part in a crew equipment interface test, or CEIT, which helps familiarize them with equipment and payloads for the mission. Among the activities standard to a CEIT are harness training, inspection of the thermal protection system and camera operation for planned extravehicular activities, or EVAs. STS-122 is targeted for launch in December. Photo credit: NASA/Kim Shiflett

Harnessing the Risk-Related Data Supply Chain: An Information Architecture Approach to Enriching Human System Research and Operations Knowledge

NASA Technical Reports Server (NTRS)

Buquo, Lynn E.; Johnson-Throop, Kathy A.

2011-01-01

An Information Architecture facilitates the understanding and, hence, harnessing of the human system risk-related data supply chain which enhances the ability to securely collect, integrate, and share data assets that improve human system research and operations. By mapping the risk-related data flow from raw data to useable information and knowledge (think of it as a data supply chain), the Human Research Program (HRP) and Space Life Science Directorate (SLSD) are building an information architecture plan to leverage their existing, and often shared, IT infrastructure.

Red Plague Control Plan (RPCP)

NASA Technical Reports Server (NTRS)

Cooke, Robert W.

2010-01-01

SCOPE: Prescribes the minimum requirements for the control of cuprous / cupric oxide corrosion (a.k.a. Red Plague) of silver-coated copper wire, cable, and harness assemblies. PURPOSE: Targeted for applications where exposure to assembly processes, environmental conditions, and contamination may promote the development of cuprous / cupric oxide corrosion (a.k.a. Red Plague) in silver-coated copper wire, cable, and harness assemblies. Does not exclude any alternate or contractor-proprietary documents or processes that meet or exceed the baseline of requirements established by this document. Use of alternate or contractor-proprietary documents or processes shall require review and prior approval of the procuring NASA activity.

Feature selection for wearable smartphone-based human activity recognition with able bodied, elderly, and stroke patients.

PubMed

Capela, Nicole A; Lemaire, Edward D; Baddour, Natalie

2015-01-01

Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations.

Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol.

PubMed

Boccardi, Marina; Bocchetta, Martina; Morency, Félix C; Collins, D Louis; Nishikawa, Masami; Ganzola, Rossana; Grothe, Michel J; Wolf, Dominik; Redolfi, Alberto; Pievani, Michela; Antelmi, Luigi; Fellgiebel, Andreas; Matsuda, Hiroshi; Teipel, Stefan; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B

2015-02-01

The European Alzheimer's Disease Consortium and Alzheimer's Disease Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used as the standard of truth to train new tracers, and to validate automated segmentation algorithms. Training requires large and representative data sets of segmented hippocampi. This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms. Sixty-eight 1.5 T and 67 3 T volumetric structural ADNI scans from different subjects, balanced by age, medial temporal atrophy, and scanner manufacturer, were segmented by five qualified HarP tracers whose absolute interrater intraclass correlation coefficients were 0.953 and 0.975 (left and right). Labels were validated as HarP compliant through centralized quality check and correction. Hippocampal volumes (mm(3)) were as follows: controls: left = 3060 (standard deviation [SD], 502), right = 3120 (SD, 897); mild cognitive impairment (MCI): left = 2596 (SD, 447), right = 2686 (SD, 473); and Alzheimer's disease (AD): left = 2301 (SD, 492), right = 2445 (SD, 525). Volumes significantly correlated with atrophy severity at Scheltens' scale (Spearman's ρ = <-0.468, P = <.0005). Cerebrospinal fluid spaces (mm(3)) were as follows: controls: left = 23 (32), right = 25 (25); MCI: left = 15 (13), right = 22 (16); and AD: left = 11 (13), right = 20 (25). Five subjects (3.7%) presented with unusual anatomy. This work provides reference hippocampal labels for the training and certification of automated segmentation algorithms. The publicly released labels will allow the widespread implementation of the standard segmentation protocol. Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Early bioenergetic evolution

PubMed Central

Sousa, Filipa L.; Thiergart, Thorsten; Landan, Giddy; Nelson-Sathi, Shijulal; Pereira, Inês A. C.; Allen, John F.; Lane, Nick; Martin, William F.

2013-01-01

Life is the harnessing of chemical energy in such a way that the energy-harnessing device makes a copy of itself. This paper outlines an energetically feasible path from a particular inorganic setting for the origin of life to the first free-living cells. The sources of energy available to early organic synthesis, early evolving systems and early cells stand in the foreground, as do the possible mechanisms of their conversion into harnessable chemical energy for synthetic reactions. With regard to the possible temporal sequence of events, we focus on: (i) alkaline hydrothermal vents as the far-from-equilibrium setting, (ii) the Wood–Ljungdahl (acetyl-CoA) pathway as the route that could have underpinned carbon assimilation for these processes, (iii) biochemical divergence, within the naturally formed inorganic compartments at a hydrothermal mound, of geochemically confined replicating entities with a complexity below that of free-living prokaryotes, and (iv) acetogenesis and methanogenesis as the ancestral forms of carbon and energy metabolism in the first free-living ancestors of the eubacteria and archaebacteria, respectively. In terms of the main evolutionary transitions in early bioenergetic evolution, we focus on: (i) thioester-dependent substrate-level phosphorylations, (ii) harnessing of naturally existing proton gradients at the vent–ocean interface via the ATP synthase, (iii) harnessing of Na+ gradients generated by H+/Na+ antiporters, (iv) flavin-based bifurcation-dependent gradient generation, and finally (v) quinone-based (and Q-cycle-dependent) proton gradient generation. Of those five transitions, the first four are posited to have taken place at the vent. Ultimately, all of these bioenergetic processes depend, even today, upon CO2 reduction with low-potential ferredoxin (Fd), generated either chemosynthetically or photosynthetically, suggesting a reaction of the type ‘reduced iron → reduced carbon’ at the beginning of bioenergetic evolution. PMID:23754820

Hirshfeld atom refinement for modelling strong hydrogen bonds.

PubMed

Woińska, Magdalena; Jayatilaka, Dylan; Spackman, Mark A; Edwards, Alison J; Dominiak, Paulina M; Woźniak, Krzysztof; Nishibori, Eiji; Sugimoto, Kunihisa; Grabowsky, Simon

2014-09-01

High-resolution low-temperature synchrotron X-ray diffraction data of the salt L-phenylalaninium hydrogen maleate are used to test the new automated iterative Hirshfeld atom refinement (HAR) procedure for the modelling of strong hydrogen bonds. The HAR models used present the first examples of Z' > 1 treatments in the framework of wavefunction-based refinement methods. L-Phenylalaninium hydrogen maleate exhibits several hydrogen bonds in its crystal structure, of which the shortest and the most challenging to model is the O-H...O intramolecular hydrogen bond present in the hydrogen maleate anion (O...O distance is about 2.41 Å). In particular, the reconstruction of the electron density in the hydrogen maleate moiety and the determination of hydrogen-atom properties [positions, bond distances and anisotropic displacement parameters (ADPs)] are the focus of the study. For comparison to the HAR results, different spherical (independent atom model, IAM) and aspherical (free multipole model, MM; transferable aspherical atom model, TAAM) X-ray refinement techniques as well as results from a low-temperature neutron-diffraction experiment are employed. Hydrogen-atom ADPs are furthermore compared to those derived from a TLS/rigid-body (SHADE) treatment of the X-ray structures. The reference neutron-diffraction experiment reveals a truly symmetric hydrogen bond in the hydrogen maleate anion. Only with HAR is it possible to freely refine hydrogen-atom positions and ADPs from the X-ray data, which leads to the best electron-density model and the closest agreement with the structural parameters derived from the neutron-diffraction experiment, e.g. the symmetric hydrogen position can be reproduced. The multipole-based refinement techniques (MM and TAAM) yield slightly asymmetric positions, whereas the IAM yields a significantly asymmetric position.

Feature Selection for Wearable Smartphone-Based Human Activity Recognition with Able bodied, Elderly, and Stroke Patients

PubMed Central

2015-01-01

Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations. PMID:25885272

High-throughput genotyping-by-sequencing facilitates molecular tagging of a novel rust resistance gene, R 15 , in sunflower (Helianthus annuus L.).

PubMed

Ma, G J; Song, Q J; Markell, S G; Qi, L L

2018-07-01

A novel rust resistance gene, R 15 , derived from the cultivated sunflower HA-R8 was assigned to linkage group 8 of the sunflower genome using a genotyping-by-sequencing approach. SNP markers closely linked to R 15 were identified, facilitating marker-assisted selection of resistance genes. The rust virulence gene is co-evolving with the resistance gene in sunflower, leading to the emergence of new physiologic pathotypes. This presents a continuous threat to the sunflower crop necessitating the development of resistant sunflower hybrids providing a more efficient, durable, and environmentally friendly host plant resistance. The inbred line HA-R8 carries a gene conferring resistance to all known races of the rust pathogen in North America and can be used as a broad-spectrum resistance resource. Based on phenotypic assessments of 140 F 2 individuals derived from a cross of HA 89 with HA-R8, rust resistance in the population was found to be conferred by a single dominant gene (R 15 ) originating from HA-R8. Genotypic analysis with the currently available SSR markers failed to find any association between rust resistance and any markers. Therefore, we used genotyping-by-sequencing (GBS) analysis to achieve better genomic coverage. The GBS data showed that R 15 was located at the top end of linkage group (LG) 8. Saturation with 71 previously mapped SNP markers selected within this region further showed that it was located in a resistance gene cluster on LG8, and mapped to a 1.0-cM region between three co-segregating SNP makers SFW01920, SFW00128, and SFW05824 as well as the NSA_008457 SNP marker. These closely linked markers will facilitate marker-assisted selection and breeding in sunflower.

Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display.

PubMed

Brindle, Nicholas P J; Sale, Julian E; Arakawa, Hiroshi; Buerstedde, Jean-Marie; Nuamchit, Teonchit; Sharma, Shikha; Steele, Kathryn H

2013-11-15

Tie2 is a receptor tyrosine kinase that is essential for the development and maintenance of blood vessels through binding the soluble ligands angiopoietin 1 (Ang1) and 2 (Ang2). Ang1 is constitutively produced by perivascular cells and is protective of the adult vasculature. Ang2 plays an important role in blood vessel formation and is normally expressed during development. However, its re-expression in disease states, including cancer and sepsis, results in destabilization of blood vessels contributing to the pathology of these conditions. Ang2 is thus an attractive therapeutic target. Here we report the directed evolution of a ligand trap for Ang2 by harnessing the B cell somatic hypermutation machinery and coupling this to selectable cell surface display of a Tie2 ectodomain. Directed evolution produced an unexpected combination of mutations resulting in loss of Ang1 binding but maintenance of Ang2 binding. A soluble form of the evolved ectodomain binds Ang2 but not Ang1. Furthermore, the soluble evolved ectodomain blocks Ang2 effects on endothelial cells without interfering with Ang1 activity. Our study has created a novel Ang2 ligand trap and provided proof of concept for combining surface display and exogenous gene diversification in B cells for evolution of a non-immunoglobulin target.

Simulation games that integrate research, entertainment, and learning around ecosystem services

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costanza, Robert; Chichakly, Karim; Dale, Virginia

Humans currently spend over 3 billion person-hours per week playing computer games. Most of these games are purely for entertainment, but use of computer games for education has also expanded dramatically. At the same time, experimental games have become a staple of social science research but have depended on relatively small sample sizes and simple, abstract situations, limiting their range and applicability. If only a fraction of the time spent playing computer games could be harnessed for research, it would open up a huge range of new opportunities. We review the use of games in research, education, and entertainment andmore » develop ideas for integrating these three functions around the idea of ecosystem services valuation. This approach to valuation can be seen as a version of choice modeling that allows players to generate their own scenarios taking account of the trade-offs embedded in the game, rather than simply ranking pre-formed scenarios. We outline a prototype game called Lagom Island to test the proposition that gaming can be used to reveal the value of ecosystem services. Ultimately, our prototype provides a potential pathway and functional building blocks for approaching the relatively untapped potential of games in the context of ecosystem services research.« less

Simulation games that integrate research, entertainment, and learning around ecosystem services

DOE PAGES

Costanza, Robert; Chichakly, Karim; Dale, Virginia; ...

2014-11-07

Humans currently spend over 3 billion person-hours per week playing computer games. Most of these games are purely for entertainment, but use of computer games for education has also expanded dramatically. At the same time, experimental games have become a staple of social science research but have depended on relatively small sample sizes and simple, abstract situations, limiting their range and applicability. If only a fraction of the time spent playing computer games could be harnessed for research, it would open up a huge range of new opportunities. We review the use of games in research, education, and entertainment andmore » develop ideas for integrating these three functions around the idea of ecosystem services valuation. This approach to valuation can be seen as a version of choice modeling that allows players to generate their own scenarios taking account of the trade-offs embedded in the game, rather than simply ranking pre-formed scenarios. We outline a prototype game called Lagom Island to test the proposition that gaming can be used to reveal the value of ecosystem services. Ultimately, our prototype provides a potential pathway and functional building blocks for approaching the relatively untapped potential of games in the context of ecosystem services research.« less

ClusterCAD: a computational platform for type I modular polyketide synthase design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eng, Clara H.; Backman, Tyler W H; Bailey, Constance B.

Here, we present ClusterCAD, a web-based toolkit designed to leverage the collinear structure and deterministic logic of type I modular polyketide synthases (PKSs) for synthetic biology applications. The unique organization of these megasynthases, combined with the diversity of their catalytic domain building blocks, has fueled an interest in harnessing the biosynthetic potential of PKSs for the microbial production of both novel natural product analogs and industrially relevant small molecules. However, a limited theoretical understanding of the determinants of PKS fold and function poses a substantial barrier to the design of active variants, and identifying strategies to reliably construct functional PKSmore » chimeras remains an active area of research. In this work, we formalize a paradigm for the design of PKS chimeras and introduce ClusterCAD as a computational platform to streamline and simplify the process of designing experiments to test strategies for engineering PKS variants. ClusterCAD provides chemical structures with stereochemistry for the intermediates generated by each PKS module, as well as sequence- and structure-based search tools that allow users to identify modules based either on amino acid sequence or on the chemical structure of the cognate polyketide intermediate. ClusterCAD can be accessed at https://clustercad.jbei.org and at http://clustercad.igb.uci.edu.« less

Conversion of Amides to Esters by the Nickel-Catalyzed Activation of Amide C–N Bonds

PubMed Central

Hie, Liana; Fine Nathel, Noah F.; Shah, Tejas K.; Baker, Emma L.; Hong, Xin; Yang, Yun-Fang; Liu, Peng; Houk, K. N.; Garg, Neil K.

2015-01-01

Amides are common functional groups that have been well studied for more than a century.1 They serve as the key building blocks of proteins and are present in an broad range of other natural and synthetic compounds. Amides are known to be poor electrophiles, which is typically attributed to resonance stability of the amide bond.1,2 Whereas Nature can easily cleave amides through the action of enzymes, such as proteases,3 the ability to selectively break the C–N bond of an amide using synthetic chemistry is quite difficult. In this manuscript, we demonstrate that amide C–N bonds can be activated and cleaved using nickel catalysts. We have used this methodology to convert amides to esters, which is a challenging and underdeveloped transformation. The reaction methodology proceeds under exceptionally mild reaction conditions, and avoids the use of a large excess of an alcohol nucleophile. Density functional theory (DFT) calculations provide insight into the thermodynamics and catalytic cycle of this unusual transformation. Our results provide a new strategy to harness amide functional groups as synthons and are expected fuel the further use of amides for the construction of carbon–heteroatom or carbon–carbon bonds using non-precious metal catalysis. PMID:26200342

Maximum Potential of the Car Cabin Temperature in the Outdoor Parking Conditions as a Source of Energy in Thermoelectric Generator

NASA Astrophysics Data System (ADS)

Sunawar, A.; Garniwa, I.

2017-03-01

Cars using the principle of converting heat energy into mechanical energy, but a lot of wasted heat energy not entirely transformed into mechanical energy, studies have been conducted that converts the heat energy into electrical energy using the principle thermoelectrically. However, there are many other energies that can be harnessed from the car, such as when the car is parked in the sun or driving in the heat of the sun, the temperature in the cabin can reach 80 degrees Celsius. The heat can be harmful to humans and the children immediately into the vehicle, as well as for the goods stored in the cabin if it contains toxins can evaporate because of the heat and dangerous. The danger can be prevented by reducing the heat in the cabin and transform into other forms of energy such as electricity. By providing a temperature difference of 40 degrees on the cold side of the module can be acquired electricity thermoelectrically up to 0.17W for one of its module, if it is made a module block the energy produced is enough to lower the temperature and charge batteries for further cooling. This study will use experiment method to get the maximum drop in temperature in the car cabin

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers

PubMed Central

LaBelle, James L.; Katz, Samuel G.; Bird, Gregory H.; Gavathiotis, Evripidis; Stewart, Michelle L.; Lawrence, Chelsea; Fisher, Jill K.; Godes, Marina; Pitter, Kenneth; Kung, Andrew L.; Walensky, Loren D.

2012-01-01

Cancer cells subvert the natural balance between cellular life and death, achieving immortality through pathologic enforcement of survival pathways and blockade of cell death mechanisms. Pro-apoptotic BCL-2 family proteins are frequently disarmed in relapsed and refractory cancer through genetic deletion or interaction-based neutralization by overexpressed antiapoptotic proteins, resulting in resistance to chemotherapy and radiation treatments. New pharmacologic strategies are urgently needed to overcome these formidable apoptotic blockades. We harnessed the natural killing activity of BCL-2–interacting mediator of cell death (BIM), which contains one of the most potent BH3 death domains of the BCL-2 protein family, to restore BH3-dependent cell death in resistant hematologic cancers. A hydrocarbon-stapled peptide modeled after the BIM BH3 helix broadly targeted BCL-2 family proteins with high affinity, blocked inhibitory antiapoptotic interactions, directly triggered proapoptotic activity, and induced dose-responsive and BH3 sequence–specific cell death of hematologic cancer cells. The therapeutic potential of stapled BIM BH3 was highlighted by the selective activation of cell death in the aberrant lymphoid infiltrates of mice reconstituted with BIM-deficient bone marrow and in a human AML xenograft model. Thus, we found that broad and multimodal targeting of the BCL-2 family pathway can overcome pathologic barriers to cell death. PMID:22622039

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Luca, A., E-mail: antonio.deluca@fis.unical.it; Dhama, R.; Rashed, A. R.

We report on the broadband resonant energy transfer processes observed in dye doped gold nanoshells, consisting of spherical particles with a dielectric core (SiO{sub 2}) covered by a thin gold shell. The silica core has been doped with rhodamine B molecules in order to harness a coherent plasmon-exciton coupling between chromophores and plasmonic shell. This plasmon-exciton interplay depends on the relative spectral position of their bands. Here, we present a simultaneous double strong coupling plasmon-exciton and exciton-plasmon. Indeed, experimental observations reveal of a transmittance enhancement as function of the gain in a wide range of optical wavelengths (about 100 nm), whilemore » scattering cross sections remains almost unmodified. These results are accompanied by an overall reduction of chromophore fluorescence lifetimes that are a clear evidence of nonradiative energy transfer processes. The increasing of transmission in the range of 630–750 nm is associated with a striking enhancement of the extinction cross-section in the 510–630 nm spectral region. In this range, the system assumes super-absorbing features. This double behavior, as well as the broadband response of the presented system, represents a promising step to enable a wide range of electromagnetic properties and fascinating applications of plasmonic nanoshells as building blocks for advanced optical materials.« less

ClusterCAD: a computational platform for type I modular polyketide synthase design

DOE PAGES

Eng, Clara H.; Backman, Tyler W H; Bailey, Constance B.; ...

2017-10-11

Here, we present ClusterCAD, a web-based toolkit designed to leverage the collinear structure and deterministic logic of type I modular polyketide synthases (PKSs) for synthetic biology applications. The unique organization of these megasynthases, combined with the diversity of their catalytic domain building blocks, has fueled an interest in harnessing the biosynthetic potential of PKSs for the microbial production of both novel natural product analogs and industrially relevant small molecules. However, a limited theoretical understanding of the determinants of PKS fold and function poses a substantial barrier to the design of active variants, and identifying strategies to reliably construct functional PKSmore » chimeras remains an active area of research. In this work, we formalize a paradigm for the design of PKS chimeras and introduce ClusterCAD as a computational platform to streamline and simplify the process of designing experiments to test strategies for engineering PKS variants. ClusterCAD provides chemical structures with stereochemistry for the intermediates generated by each PKS module, as well as sequence- and structure-based search tools that allow users to identify modules based either on amino acid sequence or on the chemical structure of the cognate polyketide intermediate. ClusterCAD can be accessed at https://clustercad.jbei.org and at http://clustercad.igb.uci.edu.« less

Neutrophil mobilization by surface-glycan altered Th17-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss.

PubMed

Settem, Rajendra P; Honma, Kiyonobu; Sharma, Ashu

2014-01-01

Alveolar bone (tooth-supporting bone) erosion is a hallmark of periodontitis, an inflammatory disease that often leads to tooth loss. Periodontitis is caused by a select group of pathogens that form biofilms in subgingival crevices between the gums and teeth. It is well-recognized that the periodontal pathogen Porphyromonas gingivalis in these biofilms is responsible for modeling a microbial dysbiotic state, which then initiates an inflammatory response destructive to the periodontal tissues and bone. Eradication of this pathogen is thus critical for the treatment of periodontitis. Previous studies have shown that oral inoculation in mice with an attenuated strain of the periodontal pathogen Tannerella forsythia altered in O-glycan surface composition induces a Th17-linked mobilization of neutrophils to the gingival tissues. In this study, we sought to determine if immune priming with such a Th17-biasing strain would elicit a productive neutrophil response against P. gingivalis. Our data show that inoculation with a Th17-biasing T. forsythia strain is effective in blocking P. gingivalis-persistence and associated alveolar bone loss in mice. This work demonstrates the potential of O-glycan modified Tannerella strains or their O-glycan components for harnessing Th17-mediated immunity against periodontal and other mucosal pathogens.

Layer-by-layer assembly of nanostructured composites: Mechanics and applications

NASA Astrophysics Data System (ADS)

Podsiadlo, Paul

The development of efficient methods for preparation of nanometer-sized materials and our evolving ability to manipulate the nanoscale objects have brought about a scientific and technological revolution called: nanotechnology. This revolution has been especially driven by discovery of unique nanoscale properties of the nanomaterials which are governed by their inherent size. Today, the total societal impact of nanotechnology is expected to be greater than the combined influences that the silicon integrated circuit, medical imaging, computer-aided engineering, and man-made polymers have had in the last century. Many nanomaterials were also found to possess exceptional mechanical properties. This led to tremendous interest into developing composite materials by exploiting the mechanical properties of these building blocks. In spite of a tremendous volume of work done in the field, preparation of such nanocomposites (NCs) has proven to be elusive due to inability of traditional "top-down" fabrication approaches to effectively harness properties of the nano-scale building blocks. This thesis focuses on preparation of organic/inorganic and solely organic NCs via a bottom-up nano-manufacturing approach called the layer-by-layer (LBL) assembly. Two natural and inexpensive nanoscale building blocks are explored: nanosheets of Na+-montmorillonite clay (MTM) and rod-shaped nanocrystals of cellulose (CNRs). In the first part of the thesis, we present results from systematic study of mechanics of MTM-based NCs. Different compositions are explored with a goal of understanding the nanoscale mechanics. Ultimately, development of a transparent composite with record-high strength and stiffness is presented. In the second part, we present results from LBL assembly of the CNRs. We demonstrate feasibility of assembly and mechanical properties of the resulting films. We also demonstrate preparation of LBL films with anti- reflective properties from tunicate (a sea animal) CNRs. In the final part, we show preparation of high toughness and hierarchically organized NCs using two concepts: "exponential" LBL (e-LBL) assembly and charged polyurethanes. We show preparation of novel e-LBL structures and highly flexible LBL multilayers. We also demonstrate preparation of macro-scale composites from hierarchical, post-assembly consolidation of LBL sheets. This last result represents a potential paradigm change in the practice of LBL assembly by enabling transformation of the thin-films into macro-scale structures.

NASA's Space Launch System: Moving Toward the Launch Pad

NASA Technical Reports Server (NTRS)

Creech, Stephen D.; May, Todd A.

2013-01-01

The National Aeronautics and Space Administration's (NASA's) Space Launch System (SLS) Program, managed at the Marshall Space Flight Center (MSFC), is making progress toward delivering a new capability for human space flight and scientific missions beyond Earth orbit. Designed with the goals of safety, affordability, and sustainability in mind, the SLS rocket will launch the Orion Multi-Purpose Crew Vehicle (MPCV), equipment, supplies, and major science missions for exploration and discovery. Supporting Orion's first autonomous flight to lunar orbit and back in 2017 and its first crewed flight in 2021, the SLS will evolve into the most powerful launch vehicle ever flown via an upgrade approach that will provide building blocks for future space exploration. NASA is working to deliver this new capability in an austere economic climate, a fact that has inspired the SLS team to find innovative solutions to the challenges of designing, developing, fielding, and operating the largest rocket in history. This paper will summarize the planned capabilities of the vehicle, the progress the SLS Program has made in the 2 years since the Agency formally announced its architecture in September 2011, the path it is following to reach the launch pad in 2017 and then to evolve the 70 metric ton (t) initial lift capability to 130-t lift capability after 2021. The paper will explain how, to meet the challenge of a flat funding curve, an architecture was chosen that combines the use and enhancement of legacy systems and technology with strategic new developments that will evolve the launch vehicle's capabilities. This approach reduces the time and cost of delivering the initial 70 t Block 1 vehicle, and reduces the number of parallel development investments required to deliver the evolved 130 t Block 2 vehicle. The paper will outline the milestones the program has already reached, from developmental milestones such as the manufacture of the first flight hardware, to life-cycle milestones such as the vehicle's Preliminary Design Review (PDR). The paper will also discuss the remaining challenges both in delivering the 70-t vehicle and in evolving its capabilities to the 130-t vehicle, and how NASA plans to accomplish these goals. As this paper will explain, SLS is making measurable progress toward becoming a global infrastructure asset for robotic and human scouts of all nations by harnessing business and technological innovations to deliver sustainable solutions for space exploration.

Harnessing collaborative technology to accelerate achievement of chronic disease management objectives for Canada.

PubMed

Thompson, Leslee J; Healey, Lindsay; Falk, Will

2007-01-01

Morgan and colleagues put forth a call to action for the transformation of the Canadian healthcare system through the adoption of a national chronic disease prevention and management (CDPM) strategy. They offer examples of best practices and national solutions including investment in clinical information technologies to help support improved care and outcomes. Although we acknowledge that the authors propose CDPM solutions that are headed in the right direction, more rapid deployment of solutions that harness the potential of advanced collaborative technologies is required. We provide examples of how technologies that exist today can help to accelerate the achievement of some key CDPM objectives.

Filgrastim for the treatment of hematopoietic acute radiation syndrome.

PubMed

Farese, A M; MacVittie, T J

2015-09-01

The U.S. Food and Drug Administration (FDA) recently approved Neupogen(®) (filgrastim) for the treatment of patients with radiation-induced myelosuppression following a radiological/nuclear incident. It is the first medical countermeasure currently approved by the FDA for this indication under the criteria of the FDA "animal rule". This article summarizes the consequences of high-dose radiation exposure, a description of the hematopoietic acute radiation syndrome (H-ARS), the use of hematopoietic growth factors in radiation accident victims and current available treatments for H-ARS with an emphasis on the use of Neupogen in this scenario. Copyright 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

Does the OVX matter for volatility forecasting? Evidence from the crude oil market

NASA Astrophysics Data System (ADS)

Lv, Wendai

2018-02-01

In this paper, I investigate that whether the OVX and its truncated parts with a certain threshold can significantly help in forecasting the oil futures price volatility basing on the Heterogeneous Autoregressive model of Realized Volatility (HAR-RV). In-sample estimation results show that the OVX has a significantly positive impact on futures volatility. The impact of large OVX on future volatility has slightly powerful compared to the small ones. Moreover, the HARQ-RV model outperforms the HAR-RV in predicting the oil futures volatility. More importantly, the decomposed OVX have more powerful in forecasting the oil futures price volatility compared to the OVX itself.

"Hello, World!" Harnessing Social Media for the Rosetta Mission

NASA Astrophysics Data System (ADS)

Baldwin, E.; Mignone, C.; Scuka, D.; Homfeld, A. M.; Ranero, K.; Rolfe, E.; Bennett, M.; Schepers, A.; O'Flaherty, K. S.; Bauer, M.; McCaughrean, M.

2016-03-01

The European Space Agency's comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. As it reached its destination ten years later, new audiences were reached and inspired by this once-in-a-lifetime event by harnessing a range of outlets for communicating the key messages. These included traditional online platforms, such as news websites, blogs, and Livestream, as well as Twitter, Facebook, Instagram, Flickr, YouTube, Google+ and SoundCloud. In this article, we outline the role social media channels played in making Rosetta one of the European Space Agency's biggest communication and public engagement successes.

Features of the solar array drive mechanism for the space telescope

NASA Technical Reports Server (NTRS)

Hostenkamp, R. G.

1985-01-01

The solar array drive mechanism for the Space Telescope embodies several features not customarily found on solar array drives. Power and signal transfer is achieved by means of a flexible wire harness for which the chosen solution, consisting of 168 standard wires, is described. The torque performance data of the harness over its temperature range are presented. The off load system which protects the bearings from the launch loads is released by a trigger made from Nitinol, the memory alloy. The benefits of memory alloy and the caveats for the design are briefly discussed. The design of the off load system is described and test experience is reported.

NASA requirements and applications environments for electrical power wiring

NASA Technical Reports Server (NTRS)

Stavnes, Mark W.; Hammoud, Ahmad N.

1992-01-01

Serious problems can occur from insulation failures in the wiring harnesses of aerospace vehicles. In most recorded incidents, the failures have been identified to be the result of arc tracking, the propagation of an arc along wiring bundles through degradation of insulation. Propagation of the arc can lead to the loss of the entire wiring harness and the functions which it supports. While an extensive database of testing for arc track resistant wire insulations has been developed for aircraft applications, the counterpart requirements for spacecraft are very limited. The electrical, thermal, mechanical, chemical, and operational requirements for specification and testing of candidate wiring systems for spacecraft applications is presented.

Deaf Workers in Restaurant, Retail, and Hospitality Sector Employment: Harnessing Research to Promote Advocacy.

PubMed

Stokar, Hayley

2017-01-01

A quarter-century after the passage of the Americans with Disabilities Act (ADA, 1990 ), workplace accommodation is still a struggle for deaf employees and their managers. Many challenges are the result of communication barriers that can be overcome through much needed-although often absent-advocacy and training. This article highlights the literature on the employment of deaf individuals in the United States service industries of food service, retail, and hospitality conducted from 2000 to 2016. Exploring dimensions of both hiring and active workplace accommodation, suggestions are made for how social work advocates can harness information and strengthen their approaches for educating managers and supporting workers.

Business-IT Alignment in Trade Facilitation: A Case Study

NASA Astrophysics Data System (ADS)

Adaba, Godfried; Rusu, Lazar; El-Mekawy, Mohamed

In the information age, no organization can thrive without harnessing the power of IT. The effective deployment of IT to achieve business goals and gain competitive advantage requires the alignment of business and IT strategies of organizations. Using the Strategic Alignment Maturity model, this paper evaluates strategic alignment maturity of Customs Excise Preventive service, a frontline public organization charged with trade facilitation in Ghana. Strategic alignment maturity is at level 3; which implies the existence of an established process to leverage IT for efficiency and effectiveness. Efforts are required to strengthen alignment and fully harness the potential of IT to facilitate trade in Ghana.

The Impact of Harness Impedance on Hall Thruster Discharge Oscillations

NASA Technical Reports Server (NTRS)

Pinero, Luis R.

2017-01-01

Hall thrusters exhibit characteristic discharge voltage and current oscillations during steady-state operation. The lower frequency breathing-mode current oscillations are inherent to each thruster and could impact thruster operation and power processing unit (PPU) design. The design of the discharge output filter, in particular, the output capacitor is important because it supplies the high peak current oscillations that the thruster demands. However, space-rated, high-voltage capacitors are not readily available and can have significant mass and volume. So, it is important for a PPU designer to know what is the minimum amount of capacitance required to operate a thruster. Through Simulation Program with Integrated Circuit Emphasis modeling and electrical measurements on the Hall Effect Rocket with Magnetic Shielding thruster, it was shown that the harness impedance between the power supply and the thruster is the main contributor towards generating voltage ripple at the thruster. Also, increasing the size of the discharge filter capacitor, as previously implemented during thruster tests, does not reduce the voltage oscillations. The electrical characteristics of the electrical harness between the discharge supply and the thruster is crucial to system performance and could have a negative impact on performance, life and operation.

Fibre optics in the SMOS mission

NASA Astrophysics Data System (ADS)

Kudielka, K.; Benito-Hernández, F. J.; Rits, W.; Martin-Neira, M.

2017-11-01

Launched on November 2nd, 2009, SMOS (Soil Moisture, Ocean Salinity) is the second Earth Explorer Opportunity mission developed as part of ESA's Living Planet Programme. It demonstrates a completely new type of instrument - a large, deployable synthetic-aperture microwave radiometer [1]. RUAG Space, Switzerland, as a subcontractor of EADS Astrium, Spain, has provided the instrument's fibreoptic harness, which interconnects the central data processor with all 69 microwave receivers, as well as 12 auxiliary units on board. For reasons explained in Section 3, SMOS is the first European mission extensively using both fibre-optic clock distribution and data transmission in space. In Section 2, we present an overview of the scientific goals of SMOS, and describe the payload's basic function. There from we derive the rationale and the design of the fibre-optic harness (Section 3). In Section 4 all development, manufacturing, and test activities are summarised, which culminated in the successful delivery of all flight units to EADS Astrium by October 2006. We present the major test results obtained with the flight harness (Section 5), and conclude with a short summary of the higher-level activities, which lead to successful launch and commissioning of the SMOS satellite (Section 6).

Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon.

PubMed

Cheng, Feiyue; Gong, Luyao; Zhao, Dahe; Yang, Haibo; Zhou, Jian; Li, Ming; Xiang, Hua

2017-11-20

Research on CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated protein) systems has led to the revolutionary CRISPR/Cas9 genome editing technique. However, for most archaea and half of bacteria, exploitation of their native CRISPR-Cas machineries may be more straightforward and convenient. In this study, we harnessed the native type I-B CRISPR-Cas system for precise genome editing in the polyploid haloarchaeon Haloarcula hispanica. After testing different designs, the editing tool was optimized to be a single plasmid that carries both the self-targeting mini-CRISPR and a 600-800 bp donor. Significantly, chromosomal modifications, such as gene deletion, gene tagging or single nucleotide substitution, were precisely introduced into the vast majority of the transformants. Moreover, we showed that simultaneous editing of two genomic loci could also be readily achieved by one step. In summary, our data demonstrate that the haloarchaeal CRISPR-Cas system can be harnessed for genome editing in this polyploid archaeon, and highlight the convenience and efficiency of the native CRISPR-based genome editing strategy. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

The Impact of Harness Impedance on Hall Thruster Discharge Oscillations

NASA Technical Reports Server (NTRS)

Pinero, Luis R.

2017-01-01

Hall thrusters exhibit characteristic discharge voltage and current oscillations during steady-state operation. The lower frequency breathing-mode current oscillations are inherent to each thruster and could impact thruster operation and PPU design. The design of the discharge output filter, in particular, the output capacitor is important because it supplies the high peak current oscillations that the thruster demands. However, space-rated, high-voltage capacitors are not readily available and can have significant mass and volume. So, it is important for a PPU designer to know what is the minimum amount of capacitance required to operate a thruster. Through SPICE modeling and electrical measurements on the Hall Effect Rocket with Magnetic Shielding (HERMeS) thruster, it was shown that the harness impedance between the power supply and the thruster is the main contributor towards generating voltage ripple at the thruster. Also, increasing the size of the discharge filter capacitor, as previously implemented during thruster tests, does not reduce the voltage oscillations. The electrical characteristics of the electrical harness between the discharge supply and the thruster is crucial to system performance and could have a negative impact on performance, life and operation.

Cryogenic on-orbit liquid depot storage acquisition and transfer (COLD-SAT) experiment subsystem instrumentation and wire harness design report

NASA Technical Reports Server (NTRS)

Edwards, Lawrence G.

1994-01-01

Subcritical cryogens such as liquid hydrogen (LH2) and liquid oxygen (LO2) are required for space based transportation propellant, reactant, and life support systems. Future long-duration space missions will require on-orbit systems capable of long-term cryogen storage and efficient fluid transfer capabilities. COLD-SAT, which stands for cryogenic orbiting liquid depot-storage acquisition and transfer, is a free-flying liquid hydrogen management flight experiment. Experiments to determine optimum methods of fluid storage and transfer will be performed on the COLD-SAT mission. The success of the mission is directly related to the type and accuracy of measurements made. The instrumentation and measurement techniques used are therefore critical to the success of the mission. This paper presents the results of the COLD-SAT experiment subsystem instrumentation and wire harness design effort. Candidate transducers capable of fulfilling the COLD-SAT experiment measurement requirements are identified. Signal conditioning techniques, data acquisition requirements, and measurement uncertainty analysis are presented. Electrical harnessing materials and wiring techniques for the instrumentation designed to minimize heat conduction to the cryogenic tanks and provide optimum measurement accuracy are listed.

Harnessing our very life.

PubMed

Wills, Peter R; Williams, David L F; Trussell, Denys; Mann, L R B

2013-01-01

The Aristotelian ideas of nature (physis) and technology (techné) are taken as a starting point for understanding what it would mean for technology to be truly living. Heidegger's critique of the conflation of scientific and technological thinking in the current era is accepted as demonstrating that humanity does not have a deep enough appreciation of the nature of life to harness its essence safely. Could the vision of harnessing life be realized, which we strongly doubt, living technology would give selected humans transforming powers that could be expected to exacerbate, rather than solve, current global problems. The source of human purposefulness, and hence of both technology and ethics, is identified in nature's emergent capability to instantiate informational representations in material forms. Ethics that are properly grounded in an appreciation of intrinsic value, especially that of life, demand that proposals to give humanity the capabilities of living technology address the social, political, economic, and environmental problems inherent in its development and potential deployment. Before any development is embarked on, steps must be taken to avoid living technology, whatever the term eventually designates, becoming available for destructive or antisocial purposes such as those that might devastate humanity or irrevocably damage the natural world.

The assessment of global thermo-energy performances of existing district heating systems optimized by harnessing renewable energy sources

NASA Astrophysics Data System (ADS)

Şoimoşan, Teodora M.; Danku, Gelu; Felseghi, Raluca A.

2017-12-01

Within the thermo-energy optimization process of an existing heating system, the increase of the system's energy efficiency and speeding-up the transition to green energy use are pursued. The concept of multi-energy district heating system, with high harnessing levels of the renewable energy sources (RES) in order to produce heat, is expected to be the key-element in the future urban energy infrastructure, due to the important role it can have in the strategies of optimizing and decarbonizing the existing district heating systems. The issues that arise are related to the efficient integration of different technologies of harnessing renewable energy sources in the energy mix and to the increase of the participation levels of RES, respectively. For the holistic modeling of the district heating system, the concept of the energy hub was used, where the synergy of different primary forms of entered energy provides the system a high degree energy security and flexibility in operation. The optimization of energy flows within the energy hub allows the optimization of the thermo-energy district system in order to approach the dual concept of smart city & smart energy.

Sensor/Transducer Bus Alternatives for Space derived from Automotive Networks

NASA Astrophysics Data System (ADS)

Heyer, H.-V.

2004-06-01

Both automotive and space industry have major constraints concerning cable and harness. As in a satellite, the dry mass of the harness in the empty car is about 3.3% of the total car mass and the harness costs are about 12% of the total production cost. So a lot of new architectural communication and power distribution concepts are needed to reduce these drawbacks. One of the possible solutions is the use of distributed bus systems which contains in a decentralized topology busses such as CAN, TTCAN or FLEX-RAY for hard-real-time applications, MOST for fast video communication via optical fiber cabling and fire wire IEEE1394 as backbone.For the general purpose sensor/actuator tasks a simple robust one-wire bus has been defined, the Local Interconnect Network (LIN) bus. This bus is an open standard which is supported by several semiconductor manufactures. The bus was firstly introduced in 1999 and has now reached an acceptable maturity with version 2.0 turning out to be quite interesting as sensor / transducer bus for space applications.This presentation will focus on the LIN Bus and present an overview of that bus.

Source and path identification of metals pollution in a mining area by PMF and rare earth element patterns in road dust.

PubMed

Tian, Shuhan; Liang, Tao; Li, Kexin; Wang, Lingqing

2018-08-15

To better assess pollution and offer efficient protection for local residents, it is necessary to both conduct an exhaustive investigation into pollution levels and quantify its contributing sources and paths. As it is the biggest light rare earth element (REE) reserve in the world, Bayan Obo deposit releases large amounts of heavy metals into the surrounding environment. In this study, road dust from zones located at different distances to the mining area was collected and sieved using seven sizes. This allowed for subsequent analysis of size-dependent influences of mining activities. A receptor model was used to quantitatively assess mine contributions. REE distribution patterns and other REE parameters were compared with those in airborne particulates and the surrounding soil to analyze pollution paths. Results showed that 27 metals were rated as moderately to extremely polluted (2

The Population Size of the Lesser Bandicoot (Bandicota bengalensis) in Three Markets in Penang, Malaysia

PubMed Central

Khairuddin, Nurul Liyana; Raghazli, Razlina; Sah, Shahrul Anuar Mohd; Shafie, Nur Juliani; Azman, Nur Munira

2011-01-01

A study of the population size of Bandicota bengalensis rats in three markets in Penang was conducted from April 2004 through May 2005. Taman Tun Sardon Market (TTS), Batu Lanchang Market (BTLG) and Bayan Lepas Market (BYNLP) were surveyed. Six sampling sessions were conducted in each market for four consecutive nights per session. The total captures of B. bengalensis in TTS, BTLG and BYNLP were 92%, 73% and 89% respectively. The total population of B. bengalensis in TTS was estimated as 265.4 (with a 95% confidence interval of 180.9–424.2). The total population at BTLG was estimated as 69.9 (with a 95% confidence interval of 35.5–148.9). At BYNLP, the total population was estimated as 134.7 (with a 95% confidence interval of 77.8–278.4). In general, adult male rats were captured most frequently at each site (55.19%), followed by adult females (31.69%), juvenile males (9.84%) and juvenile females (3.27%). The results showed that the number of rats captured at each site differed significantly according to sex ratio and maturity (χ2 = 121.45, df = 3, p<0.01). Our results suggest that the population sizes found by the study may not represent the actual population size in each market owing to the low numbers of rats recaptured. This finding might have resulted from the variety of foods available in the markets. PMID:24575219

Classical conditioning of proboscis extension in harnessed Africanized honey bee queens (Apis mellifera L.).

PubMed

Aquino, Italo S; Abramson, Charles I; Soares, Ademilson E E; Fernandes, Andrea Cardoso; Benbassat, Danny

2004-06-01

Experiments are reported on learning in virgin Africanized honey bee queens (Apis mellifera L.). Queens restrained in a "Pavlovian harness" received a pairing of hexanal odor with a 1.8-M feeding of sucrose solution. Compared to explicitly unpaired controls, acquisition was rapid in reaching about 90%. Acquisition was also rapid in queens receiving an unconditioned stimulus of "bee candy" or an unconditioned stimulus administered by worker bees. During extinction the conditioned response declines. The steepest decline was observed in queens receiving an unconditioned stimulus of bee candy. These findings extend previous work on learning of Afrianized honey bee workers to a population of queen bees.

Harnessing dendritic cells in inflammatory skin diseases

PubMed Central

Chu, Chung-Ching; Di Meglio, Paola; Nestle, Frank O.

2011-01-01

The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. PMID:21295490

Imidazolium-labeled glycosides as probes to harness glycosyltransferase activity in human breast milk† †Electronic supplementary information (ESI) available: Full experimental and characterization data for all compounds, including NMR spectra and LC-MS traces. See DOI: 10.1039/c7ob00550d

PubMed Central

Sittel, I.

2017-01-01

Imidazolium-labeled (ITag-) glycosides are used to harness the glycosyltransferase activity directly from human breast milk. The covalently attached ionic labels provide a bifunctional chemical handle that is used to monitor reaction progress by MS, as well as aid in product purification from complex mixtures. The technology is exemplified in the synthesis of biologically relevant oligosaccharide analogs, LacNAc-ITag, ITag-Lewisx and ITag-Lewisa, in a matter of days from human breast milk without having to isolate specific enzymes. PMID:28401975

Demonstration of a Nano-Enabled Space Power System

NASA Technical Reports Server (NTRS)

Raffaelle, Ryne; Hunter, Roger C.; Baker, Christopher

2017-01-01

The Nano-Enabled Space Power System will demonstrate power systems with nanomaterial-enhanced components as are placement for CubeSat power generation, transmission, and storage. Successful flights of these nano-power systems will accelerate the use of this revolutionary technology in the aerospace industry. The use of nano materials in solar cells, wire harnesses,and lithium ion batteries can increase the device performance without significantly altering the devices physical dimensions or the devices operating range (temperature,voltage, current). In many cases, the use of nanomaterials widens the viable range of operating conditions, such as increased depth of discharge of lithium ion batteries, tunable bandgaps in solar cells, and increased flexure tolerance of wire harnesses.

A 3D Model to Compute Lightning and HIRF Coupling Effects on Avionic Equipment of an Aircraft

NASA Astrophysics Data System (ADS)

Perrin, E.; Tristant, F.; Guiffaut, C.; Terrade, F.; Reineix, A.

2012-05-01

This paper describes the 3D FDTD model of an aircraft developed to compute the lightning and HIRF (High Intentity Radiated Fields) coupling effects on avionic equipment and all the wire harness associated. This virtual prototype aims at assisting the aircraft manufacturer during the lightning and HIRF certification processes. The model presented here permits to cover a frequency range from lightning spectrum to the low frequency HIRF domain, i.e. 0 to 100 MHz. Moreover, the entire aircraft, including the frame, the skin, the wire harness and the equipment are taken into account in only one model. Results obtained are compared to measurements on a real aircraft.

A battery-less photo-detector enabled with simultaneous ferroelectric sensing and energy harnessing mechanism

NASA Astrophysics Data System (ADS)

Lai, Szu Cheng; Yao, Kui; Chen, Yi Fan

2013-08-01

A self-sustainable mechanism for simultaneously sensing and harnessing photon energy was proposed and implemented to create a battery-less and wire-less ultraviolet sensor made of ferroelectric lead lanthanum zirconate titanate thin film with in-plane polarization configuration. The mechanism involved accumulating and storing the photovoltaic charge, and transferring the stored charge via a piezoelectric switch to a radio frequency transmitter. The time-interval between the radio frequency pulses generated by the transmitter was inversely proportional to the photo-intensity. The sustainability of the operation was ascribed to the low leakage, high photovoltage, and linear current-voltage characteristics of ferroelectric sensing material instead of semiconductors.

Training Classifiers with Shadow Features for Sensor-Based Human Activity Recognition.

PubMed

Fong, Simon; Song, Wei; Cho, Kyungeun; Wong, Raymond; Wong, Kelvin K L

2017-02-27

In this paper, a novel training/testing process for building/using a classification model based on human activity recognition (HAR) is proposed. Traditionally, HAR has been accomplished by a classifier that learns the activities of a person by training with skeletal data obtained from a motion sensor, such as Microsoft Kinect. These skeletal data are the spatial coordinates (x, y, z) of different parts of the human body. The numeric information forms time series, temporal records of movement sequences that can be used for training a classifier. In addition to the spatial features that describe current positions in the skeletal data, new features called 'shadow features' are used to improve the supervised learning efficacy of the classifier. Shadow features are inferred from the dynamics of body movements, and thereby modelling the underlying momentum of the performed activities. They provide extra dimensions of information for characterising activities in the classification process, and thereby significantly improve the classification accuracy. Two cases of HAR are tested using a classification model trained with shadow features: one is by using wearable sensor and the other is by a Kinect-based remote sensor. Our experiments can demonstrate the advantages of the new method, which will have an impact on human activity detection research.

Training Classifiers with Shadow Features for Sensor-Based Human Activity Recognition

PubMed Central

Fong, Simon; Song, Wei; Cho, Kyungeun; Wong, Raymond; Wong, Kelvin K. L.

2017-01-01

In this paper, a novel training/testing process for building/using a classification model based on human activity recognition (HAR) is proposed. Traditionally, HAR has been accomplished by a classifier that learns the activities of a person by training with skeletal data obtained from a motion sensor, such as Microsoft Kinect. These skeletal data are the spatial coordinates (x, y, z) of different parts of the human body. The numeric information forms time series, temporal records of movement sequences that can be used for training a classifier. In addition to the spatial features that describe current positions in the skeletal data, new features called ‘shadow features’ are used to improve the supervised learning efficacy of the classifier. Shadow features are inferred from the dynamics of body movements, and thereby modelling the underlying momentum of the performed activities. They provide extra dimensions of information for characterising activities in the classification process, and thereby significantly improve the classification accuracy. Two cases of HAR are tested using a classification model trained with shadow features: one is by using wearable sensor and the other is by a Kinect-based remote sensor. Our experiments can demonstrate the advantages of the new method, which will have an impact on human activity detection research. PMID:28264470

Water gate array for current flow or tidal movement pneumatic harnessing system

DOEpatents

Gorlov, Alexander M.

1991-01-01

The invention, which provides a system for harnessing power from current flow or tidal movement in a body of water, comprises first and second hydro-pneumatic chambers each having ingress and egress below the water surface near the river or ocean floor and water gates operative to open or seal the ports to the passage of water. In an exemplary embodiment, the gates are sychronized by shafts so that the ingress ports of each chamber are connected to the egress ports of each other chamber. Thus, one set of gates is closed, while the other is open, thereby allowing water to flow into one chamber and build air pressure therein and allowing water to flow out of the other chamber and create a partial vacuum therein. A pipe connects the chambers, and an air turbine harnesses the air movement within the pipe. When water levels are equilibrated, the open set of gates is closed by a counterweight, and the other set is allowed to open by natural force of the water differential. The water gates may be comprised of a plurality of louvers which are ganged for simultaneous opening and closing. The system is designed to operate with air turbines or other pneumatic devices. Its design minimizes construction cost and environmental impact, yet provides a clean renewable energy source.

Remote Sensing to Estimate Saturation Differences of Chosen Building Materials Using Terrestrial Laser Scanner

NASA Astrophysics Data System (ADS)

Suchocki, Czesław; Katzer, Jacek; Panuś, Arkadiusz

2017-06-01

Terrestrial Laser Scanner (TLS) method which is commonly used for geodetic applications has a great potential to be successfully harnessed for multiple civil engineering applications. One of the most promising uses of TLS in construction industry is remote sensing of saturation of building materials. A research programme was prepared in order to prove that harnessing TLS for such an application is viable. Results presented in the current paper are a part of a much larger research programme focused on harnessing TLS for remote sensing of saturation of building materials. The paper describes results of the tests conducted with an impulse scanner Leica C-10. Tests took place both indoors (in a stable lab conditions) and outdoors (in a real environment). There were scanned specimens of the most popular building materials in Europe. Tested specimens were dried and saturated (including capillary rising moisture). One of the tests was performed over a period of 95 hours. Basically, a concrete specimen was scanned during its setting and hardening. It was proven that absorption of a laser signal is influenced by setting and hardening of concrete. Outdoor tests were based on scanning real buildings with partially saturated facades. The saturation assessment was based on differences of values of intensity. The concept proved to be feasible and technically realistic.

The Role of Heart-Rate Variability Parameters in Activity Recognition and Energy-Expenditure Estimation Using Wearable Sensors.

PubMed

Park, Heesu; Dong, Suh-Yeon; Lee, Miran; Youn, Inchan

2017-07-24

Human-activity recognition (HAR) and energy-expenditure (EE) estimation are major functions in the mobile healthcare system. Both functions have been investigated for a long time; however, several challenges remain unsolved, such as the confusion between activities and the recognition of energy-consuming activities involving little or no movement. To solve these problems, we propose a novel approach using an accelerometer and electrocardiogram (ECG). First, we collected a database of six activities (sitting, standing, walking, ascending, resting and running) of 13 voluntary participants. We compared the HAR performances of three models with respect to the input data type (with none, all, or some of the heart-rate variability (HRV) parameters). The best recognition performance was 96.35%, which was obtained with some selected HRV parameters. EE was also estimated for different choices of the input data type (with or without HRV parameters) and the model type (single and activity-specific). The best estimation performance was found in the case of the activity-specific model with HRV parameters. Our findings indicate that the use of human physiological data, obtained by wearable sensors, has a significant impact on both HAR and EE estimation, which are crucial functions in the mobile healthcare system.

Design of a noninvasive face mask for ocular occlusion in rats and assessment in a visual discrimination paradigm.

PubMed

Hager, Audrey M; Dringenberg, Hans C

2012-12-01

The rat visual system is structured such that the large (>90 %) majority of retinal ganglion axons reach the contralateral lateral geniculate nucleus (LGN) and visual cortex (V1). This anatomical design allows for the relatively selective activation of one cerebral hemisphere under monocular viewing conditions. Here, we describe the design of a harness and face mask allowing simple and noninvasive monocular occlusion in rats. The harness is constructed from synthetic fiber (shoelace-type material) and fits around the girth region and neck, allowing for easy adjustments to fit rats of various weights. The face mask consists of soft rubber material that is attached to the harness by Velcro strips. Eyeholes in the mask can be covered by additional Velcro patches to occlude either one or both eyes. Rats readily adapt to wearing the device, allowing behavioral testing under different types of viewing conditions. We show that rats successfully acquire a water-maze-based visual discrimination task under monocular viewing conditions. Following task acquisition, interocular transfer was assessed. Performance with the previously occluded, "untrained" eye was impaired, suggesting that training effects were partially confined to one cerebral hemisphere. The method described herein provides a simple and noninvasive means to restrict visual input for studies of visual processing and learning in various rodent species.

Plug-and-play design approach to smart harness for modular small satellites

NASA Astrophysics Data System (ADS)

Mughal, M. Rizwan; Ali, Anwar; Reyneri, Leonardo M.

2014-02-01

A typical satellite involves many different components that vary in bandwidth demand. Sensors that require a very low data rate may reside on a simple two- or three-wire interface such as I2C, SPI, etc. Complex sensors that require high data rate and bandwidth may reside on an optical interface. The AraMiS architecture is an enhanced capability architecture with different satellite configurations. Although keeping the low-cost and COTS approach of CubeSats, it extends the modularity concept as it also targets different satellite shapes and sizes. But modularity moves beyond the mechanical structure: the tiles also have thermo-mechanical, harness and signal-processing functionalities. Further modularizing the system, every tile can also host a variable number of small sensors, actuators or payloads, connected using a plug-and-play approach. Every subsystem is housed in a small daughter board and is supplied, by the main tile, with power and data distribution functions, power and data harness, mechanical support and is attached and interconnected with space-grade spring-loaded connectors. The tile software is also modular and allows a quick adaptation to specific subsystems. The basic software for the CPU is properly hardened to guarantee high level of radiation tolerance at very low cost.