Yin, L; Xia, J S; Zapf, V S; Sullivan, N S; Paduan-Filho, A
2008-10-31
In this work, we demonstrate field-induced Bose-Einstein condensation (BEC) in the organic compound NiCl2-4SC(NH2)_{2} using ac susceptibility measurements down to 1 mK. The Ni S=1 spins exhibit 3D XY antiferromagnetism between a lower critical field H_{c1} approximately 2 T and a upper critical field H_{c2} approximately 12 T. The results show a power-law temperature dependence of the phase transition line H_{c1}(T)-H_{c1}(0)=aT;{alpha} with alpha=1.47+/-0.10 and H_{c1}(0)=2.053 T, consistent with the 3D BEC universality class. Near H_{c2}, a kink was found in the phase boundary at approximately 150 mK.
Gravitational waves as a new probe of Bose-Einstein condensate Dark Matter
NASA Astrophysics Data System (ADS)
Dev, P. S. Bhupal; Lindner, Manfred; Ohmer, Sebastian
2017-10-01
There exists a class of ultralight Dark Matter (DM) models which could give rise to a Bose-Einstein condensate (BEC) in the early universe and behave as a single coherent wave instead of individual particles in galaxies. We show that a generic BEC-DM halo intervening along the line of sight of a gravitational wave (GW) signal could induce an observable change in the speed of GWs, with the effective refractive index depending only on the mass and self-interaction of the constituent DM particles and the GW frequency. Hence, we propose to use the deviation in the speed of GWs as a new probe of the BEC-DM parameter space. With a multi-messenger approach to GW astronomy and/or with extended sensitivity to lower GW frequencies, the entire BEC-DM parameter space can be effectively probed by our new method in the near future.
Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.
Shimoda, Shinji; Hisamoto, Satomi; Harada, Kenichi; Iwasaka, Sho; Chong, Yong; Nakamura, Minoru; Bekki, Yuki; Yoshizumi, Tomoharu; Shirabe, Ken; Ikegami, Toru; Maehara, Yoshihiko; He, Xiao-Song; Gershwin, M Eric; Akashi, Koichi
2015-12-01
The hallmark of primary biliary cirrhosis (PBC) is the presence of autoreactive T- and B-cell responses that target biliary epithelial cells (BECs). Biliary cell cytotoxicity is dependent upon initiation of innate immune responses followed by chronic adaptive, as well as bystander, mechanisms. Critical to these mechanisms are interactions between natural killer (NK) cells and BECs. We have taken advantage of the ability to isolate relatively pure viable preparations of liver-derived NK cells, BECs, and endothelial cells, and studied interactions between NK cells and BECs and focused on the mechanisms that activate autoreactive T cells, their dependence on interferon (IFN)-γ, and expression of BEC major histocompatibility complex (MHC) class I and II molecules. Here we show that at a high NK/BEC ratio, NK cells are cytotoxic for autologous BECs, but are not dependent on autoantigen, yet still activate autoreactive CD4(+) T cells in the presence of antigen presenting cells. In contrast, at a low NK/BEC ratio, BECs are not lysed, but IFN-γ production is induced, which facilitates expression of MHC class I and II molecules on BEC and protects them from lysis upon subsequent exposure to autoreactive NK cells. Furthermore, IFN-γ secreted from NK cells after exposure to autologous BECs is essential for this protective function and enables autoreactive CD4(+) T cells to become cytopathic. NK cell-mediated innate immune responses are likely critical at the initial stage of PBC, but also facilitate and maintain the chronic cytopathic effect of autoantigen-specific T cells, essential for progression of disease. © 2015 by the American Association for the Study of Liver Diseases.
Analytical theory of mesoscopic Bose-Einstein condensation in an ideal gas
NASA Astrophysics Data System (ADS)
Kocharovsky, Vitaly V.; Kocharovsky, Vladimir V.
2010-03-01
We find the universal structure and scaling of the Bose-Einstein condensation (BEC) statistics and thermodynamics (Gibbs free energy, average energy, heat capacity) for a mesoscopic canonical-ensemble ideal gas in a trap with an arbitrary number of atoms, any volume, and any temperature, including the whole critical region. We identify a universal constraint-cutoff mechanism that makes BEC fluctuations strongly non-Gaussian and is responsible for all unusual critical phenomena of the BEC phase transition in the ideal gas. The main result is an analytical solution to the problem of critical phenomena. It is derived by, first, calculating analytically the universal probability distribution of the noncondensate occupation, or a Landau function, and then using it for the analytical calculation of the universal functions for the particular physical quantities via the exact formulas which express the constraint-cutoff mechanism. We find asymptotics of that analytical solution as well as its simple analytical approximations which describe the universal structure of the critical region in terms of the parabolic cylinder or confluent hypergeometric functions. The obtained results for the order parameter, all higher-order moments of BEC fluctuations, and thermodynamic quantities perfectly match the known asymptotics outside the critical region for both low and high temperature limits. We suggest two- and three-level trap models of BEC and find their exact solutions in terms of the cutoff negative binomial distribution (which tends to the cutoff gamma distribution in the continuous limit) and the confluent hypergeometric distribution, respectively. Also, we present an exactly solvable cutoff Gaussian model of BEC in a degenerate interacting gas. All these exact solutions confirm the universality and constraint-cutoff origin of the strongly non-Gaussian BEC statistics. We introduce a regular refinement scheme for the condensate statistics approximations on the basis of the infrared universality of higher-order cumulants and the method of superposition and show how to model BEC statistics in the actual traps. In particular, we find that the three-level trap model with matching the first four or five cumulants is enough to yield remarkably accurate results for all interesting quantities in the whole critical region. We derive an exact multinomial expansion for the noncondensate occupation probability distribution and find its high-temperature asymptotics (Poisson distribution) and corrections to it. Finally, we demonstrate that the critical exponents and a few known terms of the Taylor expansion of the universal functions, which were calculated previously from fitting the finite-size simulations within the phenomenological renormalization-group theory, can be easily obtained from the presented full analytical solutions for the mesoscopic BEC as certain approximations in the close vicinity of the critical point.
ERIC Educational Resources Information Center
Oesterle, Susan, Ed.; Allan, Darien, Ed.; Liljedahl, Peter, Ed.
2013-01-01
This submission contains the Proceedings of the 2012 Annual Meeting of the Canadian Mathematics Education Study Group (CMESG), held at Laval University in Québec City, Québec. The CMESG is a group of mathematicians and mathematics educators who meet annually to discuss mathematics education issues at all levels of learning. The aims of the Study…
Bose-Einstein condensation of dark matter axions.
Sikivie, P; Yang, Q
2009-09-11
We show that cold dark matter axions thermalize and form a Bose-Einstein condensate (BEC). We obtain the axion state in a homogeneous and isotropic universe, and derive the equations governing small axion perturbations. Because they form a BEC, axions differ from ordinary cold dark matter in the nonlinear regime of structure formation and upon entering the horizon. Axion BEC provides a mechanism for the production of net overall rotation in dark matter halos, and for the alignment of cosmic microwave anisotropy multipoles.
Walsh, Jennifer R; Hebert, Angel; Byrd-Bredbenner, Carol; Carey, Gale; Colby, Sarah; Brown-Esters, Onikia N; Greene, Geoffrey; Hoerr, Sharon; Horacek, Tanya; Kattelmann, Kendra; Kidd, Tandalayo; Koenings, Mallory; Phillips, Beatrice; Shelnutt, Karla P; White, Adrienne A
2012-01-01
To develop and test the validity of the Behavior, Environment, and Changeability Survey (BECS) for identifying the importance and changeability of nutrition, exercise, and stress management behavior and related aspects of the environment. A cross-sectional, online survey of the BECS and selected validated instruments. Ten state universities. A convenience sample of college students (n = 1,283), ages 18-24 years. Principal component analysis was used to confirm a 6-component structure of the BECS in 2 independent samples for the purpose of cross-validation. Internal consistency was measured and construct and criterion-related analyses were conducted to test the reliability and validity of the BECS subscales. Six components representing 34 BECS items were revealed from the original 69 items and explained 64% of the total variance. Six scales were retained, and internal consistency of each ranged from α = .82 to .93. BECS Nutrition Behavior and Nutrition Changeability scale scores were highest for participants in action/maintenance Stages of Change for fruit and vegetable intake. There is strong support for the use of the BECS when planning health programs to gain insight into behavior that young adults are willing to improve, specifically related to nutrition, exercise, and sleep. Copyright © 2012 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.
Inflationary Quasiparticle Creation and Thermalization Dynamics in Coupled Bose-Einstein Condensates
NASA Astrophysics Data System (ADS)
Posazhennikova, Anna; Trujillo-Martinez, Mauricio; Kroha, Johann
2016-06-01
A Bose gas in a double-well potential, exhibiting a true Bose-Einstein condensate (BEC) amplitude and initially performing Josephson oscillations, is a prototype of an isolated, nonequilibrium many-body system. We investigate the quasiparticle (QP) creation and thermalization dynamics of this system by solving the time-dependent Keldysh-Bogoliubov equations. We find avalanchelike QP creation due to a parametric resonance between BEC and QP oscillations, followed by slow, exponential relaxation to a thermal state at an elevated temperature, controlled by the initial excitation energy of the oscillating BEC above its ground state. The crossover between the two regimes occurs because of an effective decoupling of the QP and BEC oscillations. This dynamics is analogous to elementary particle creation in models of the early universe. The thermalization in our setup occurs because the BEC acts as a grand canonical reservoir for the quasiparticle system.
Posazhennikova, Anna; Trujillo-Martinez, Mauricio; Kroha, Johann
2016-06-03
A Bose gas in a double-well potential, exhibiting a true Bose-Einstein condensate (BEC) amplitude and initially performing Josephson oscillations, is a prototype of an isolated, nonequilibrium many-body system. We investigate the quasiparticle (QP) creation and thermalization dynamics of this system by solving the time-dependent Keldysh-Bogoliubov equations. We find avalanchelike QP creation due to a parametric resonance between BEC and QP oscillations, followed by slow, exponential relaxation to a thermal state at an elevated temperature, controlled by the initial excitation energy of the oscillating BEC above its ground state. The crossover between the two regimes occurs because of an effective decoupling of the QP and BEC oscillations. This dynamics is analogous to elementary particle creation in models of the early universe. The thermalization in our setup occurs because the BEC acts as a grand canonical reservoir for the quasiparticle system.
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome.
Maiuri, Maria Chiara; Criollo, Alfredo; Kroemer, Guido
2010-02-03
Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins control 'self eating' in mammalian cells remain elusive. Beclin 1 (Bec1), the mammalian orthologue of yeast Atg6, is part of the class III phosphatidylinositol 3-kinase (PI3K) complex that induces autophagy. The first among an increasing number of Bec1-interacting proteins that has been identified is the anti-apoptotic protein Bcl-2. The dissociation of Bec1 from Bcl-2 is essential for its autophagic activity, and Bcl-2 only inhibits autophagy when it is present in the endoplasmic reticulum (ER). A paper in this issue of the EMBO Journal has identified a novel protein, NAF-1 (nutrient-deprivation autophagy factor-1), that binds Bcl-2 at the ER. NAF-1 is a component of the inositol-1,4,5 trisphosphate (IP3) receptor complex, which contributes to the interaction of Bcl-2 with Bec1 and is required for Bcl-2 to functionally antagonize Bec1-mediated autophagy. This work provides mechanistic insights into how autophagy- and apoptosis-regulatory molecules crosstalk at the ER.
Otto, Simon J G; Carson, Carolee A; Finley, Rita L; Thomas, M Kate; Reid-Smith, Richard J; McEwen, Scott A
2014-11-01
A stochastic model was used to estimate the number of human cases of ceftiofur-resistant Salmonella enterica serovar Heidelberg in Québec and Ontario attributable to chicken consumption and excess cases attributable to human prior antimicrobial consumption. The annual mean incidence of S. Heidelberg (Québec/Ontario) decreased from 70/62 cases per 100 000 in 2004 to 29/30 cases per 100 000 in 2007 (Québec)/2008 (Ontario), increasing to 59/45 cases per 100 000 in 2011. The annual mean incidence of ceftiofur-resistant cases from chicken decreased from 8/7 cases per 100 000 in 2004 to 1/1 cases per 100 000 in 2007 (Québec)/2008 (Ontario), increasing to 7/5 cases per 100 000 in 2011. The annual mean total number of excess ceftiofur-resistant cases from chicken attributable to human prior antimicrobial consumption (Québec/Ontario) decreased from 71/123 in 2004 to 6/24 in 2007 (Québec)/2008 (Ontario), but increased to 62/91 in 2011. This model will support future work to determine the increased severity, mortality and healthcare costs for ceftiofur-resistant Salmonella Heidelberg infections. These results provide a basis for the evaluation of future public health interventions to address antimicrobial resistance. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
NASA Astrophysics Data System (ADS)
Endo, Charles-Anica; Emond, Claude; Battista, Renaldo; Parizeau, Marie-Hélène; Beaudry, Catherine
2011-07-01
The spectacular progress made by nanosciences and nanotechnologies elicits as much hope and fear. Consequently, a great number of research and training initiatives on the ethical, environmental, economic, legal and social issues regarding nanotechnology development (Ne3LS) are emerging worldwide. In Québec, Canada, a Task Force was mandated by NanoQuébec to conceive a Ne3LS research and training strategy to assess those issues. This Task Force brought together experts from universities, governments or industry working in nanosciences and nanotechnologies or in Ne3LS. Their resulting action plan, made public in November 2006, contained several recommendations, including the creation of a knowledge network (Ne3LS Network). In the following years, after consulting with numerous key players concerned with the possible impacts of nanosciences and nanotechnologies in Québec, the Ne3LS Network was launched in January 2010 in partnership with the Fonds québécois de la recherche sur la nature et les technologies, the Fonds québécois de la recherche sur la société et la culture and the Fonds de la recherche en santé du Québec, NanoQuébec, the Institut de recherche Robert-Sauvé en santé et en sécurité du travail as well as the University of Montreal. Its objectives are to 1) Foster the development of Ne3LS research activities (grants and fellowships); 2) Spearhead the Canadian and international Ne3LS network; 3) Take part in the training of researchers and experts; 4) Encourage the creation of interactive tools for the general public; 5) Facilitate collaboration between decision-makers and experts; 6) Involve the scientific community through a host of activities (symposium, conferences, thematic events); 7) Build multidisciplinary research teams to evaluate the impact of nanotechnology.
Can a supersonically expanding Bose-Einstein Condensates be used to study cosmological inflation?
NASA Astrophysics Data System (ADS)
Banik, Swarnav; Eckel, Stephen; Kumar, Avinash; Jacobson, Ted; Spielman, Ian; Campbell, Gretchen
2017-04-01
The massive scale of the universe makes the experimental study of cosmological inflation difficult. This has led to an interest in developing analogous systems using table top experiments. Here, we present the basic features of an expanding universe by drawing parallels with an expanding toroidal Bose Einstein Condensate (BEC) of 23Na atoms. The toroidal BEC serves as the background vacuum and phonons are the analogue to photons in the expanding universe. We study the dynamics of phonons in both non-expanding and expanding condensates and measure dissipation using the structure factor. We demonstrate red shifting of phonons and quasi-particle production similar to pre-heating after the inflation of universe. At the end of expansion, we also observe spontaneous non-zero winding numbers in the ring. Using Monte-Carlo simulations, we predict the widths of the resulting winding number distribution, which agree well with our experimental findings.
Universality of magnetic-field-induced Bose-Einstein condensation of magnons
NASA Astrophysics Data System (ADS)
Shirasawa, Kazuki; Kurita, Nobuyuki; Tanaka, Hidekazu
2017-10-01
CsFeBr3 is an S =1 hexagonal antiferromagnet that has a singlet ground state owing to its large easy-plane single-ion anisotropy. The critical behavior of the magnetic-field-induced phase transition for a magnetic field parallel to the c axis, which can be described by the Bose-Einstein condensation (BEC) of magnons under the U (1 ) symmetry, was investigated via magnetization and specific heat measurements down to 0.1 K. For the specific heat measurement, we have developed a method of effectively suppressing the torque acting on a sample with strong anisotropy that uses the spin dimer compound Ba2CoSi2O6Cl2 with large and anisotropic Van Vleck paramagnetism. The temperature dependence of the transition field Hc(T ) was found to follow the power-law Hc(T ) -Hc∝Tϕ with a critical exponent of ϕ =1.50 ±0.02 and critical field of Hc=2.60 T . This result verifies the universality of the three-dimensional BEC of magnons described by ϕBEC=3 /2 .
A new apparatus for studies of quantized vortex dynamics in dilute-gas Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Newman, Zachary L.
The presence of quantized vortices and a high level of control over trap geometries and other system parameters make dilute-gas Bose-Einstein condensates (BECs) a natural environment for studies of vortex dynamics and quantum turbulence in superfluids, primary interests of the BEC group at the University of Arizona. Such research may lead to deeper understanding of the nature of quantum fluid dynamics and far-from-equilbrium phenomena. Despite the importance of quantized vortex dynamics in the fields of superfluidity, superconductivity and quantum turbulence, direct imaging of vortices in trapped BECs remains a significant technical challenge. This is primarily due to the small size of the vortex core in a trapped gas, which is typically a few hundred nanometers in diameter. In this dissertation I present the design and construction of a new 87Rb BEC apparatus with the goal of studying vortex dynamics in trapped BECs. The heart of the apparatus is a compact vacuum chamber with a custom, all-glass science cell designed to accommodate the use of commercial high-numerical-aperture microscope objectives for in situ imaging of vortices. The designs for the new system are, in part, based on prior work in our group on in situ imaging of vortices. Here I review aspects of our prior work and discuss some of the successes and limitations that are relevant to the new apparatus. The bulk of the thesis is used to described the major subsystems of the new apparatus which include the vacuum chamber, the laser systems, the magnetic transfer system and the final magnetic trap for the atoms. Finally, I demonstrate the creation of a BEC of ˜ 2 x 106 87Rb atoms in our new system and show that the BEC can be transferred into a weak, spherical, magnetic trap with a well defined magnetic field axis that may be useful for future vortex imaging studies.
Pasquali, Christian; Stolz, Daiana; Tamm, Michael
2017-01-01
Background Bronchial epithelial cells (BEC) are primary target for Rhinovirus infection through attaching to cell membrane proteins. OM-85, a bacterial extract, improves recovery of asthma and COPD patients after viral infections, but only part of the mechanism was addressed, by focusing on defined immune cells. Objective We therefore determined the effect of OM-85 on isolated primary human BEC of controls (n = 8), asthma patients (n = 10) and COPD patients (n = 9). Methods BEC were treated with OM-85 alone (24 hours) or infected with Rhinovirus. BEC survival was monitored by manual cell counting and Rhinovirus replication by lytic activity. Immuno-blotting and ELISA were used to determine the expression of Rhinovirus interacting proteins: intracellular adhesion molecule (ICAM), major histocompatibility complex class II (MHC-2), complement component C1q receptor (C1q-R), inducible T-Cell co-stimulator (ICOS), its ligand ICOSL, and myeloid differentiation primary response gene 88 (Myd88); as well as for signal transducers Erk1/2, p38, JNK mitogen activated protein kinases MAPK), and cAMP. Results OM-85 significantly reduced Rhinovirus-induced BEC death and virus replication. OM-85 significantly increased the expression of virus interacting proteins C1q-R and β-defensin in all 3 probes and groups, which was prevented by either Erk1/2 MAPK or cAMP inhibition. In addition, OM-85 significantly reduced Rhinovirus induced expression of ICAM1 involving p38 MAPK. In BEC OM-85 had no significant effect on the expression of ICOS, ICOSL and MHC-2 membrane proteins nor on the adaptor protein MyD88. Conclusion The OM-85-induced increased of C1q-R and β-defensin, both important for antigen presentation and phagocytosis, supports its activity in host cell’s defence against Rhinovirus infection. PMID:29182620
Roth, Michael; Pasquali, Christian; Stolz, Daiana; Tamm, Michael
2017-01-01
Bronchial epithelial cells (BEC) are primary target for Rhinovirus infection through attaching to cell membrane proteins. OM-85, a bacterial extract, improves recovery of asthma and COPD patients after viral infections, but only part of the mechanism was addressed, by focusing on defined immune cells. We therefore determined the effect of OM-85 on isolated primary human BEC of controls (n = 8), asthma patients (n = 10) and COPD patients (n = 9). BEC were treated with OM-85 alone (24 hours) or infected with Rhinovirus. BEC survival was monitored by manual cell counting and Rhinovirus replication by lytic activity. Immuno-blotting and ELISA were used to determine the expression of Rhinovirus interacting proteins: intracellular adhesion molecule (ICAM), major histocompatibility complex class II (MHC-2), complement component C1q receptor (C1q-R), inducible T-Cell co-stimulator (ICOS), its ligand ICOSL, and myeloid differentiation primary response gene 88 (Myd88); as well as for signal transducers Erk1/2, p38, JNK mitogen activated protein kinases MAPK), and cAMP. OM-85 significantly reduced Rhinovirus-induced BEC death and virus replication. OM-85 significantly increased the expression of virus interacting proteins C1q-R and β-defensin in all 3 probes and groups, which was prevented by either Erk1/2 MAPK or cAMP inhibition. In addition, OM-85 significantly reduced Rhinovirus induced expression of ICAM1 involving p38 MAPK. In BEC OM-85 had no significant effect on the expression of ICOS, ICOSL and MHC-2 membrane proteins nor on the adaptor protein MyD88. The OM-85-induced increased of C1q-R and β-defensin, both important for antigen presentation and phagocytosis, supports its activity in host cell's defence against Rhinovirus infection.
Beclometasone oral--DOR BioPharma.
2007-01-01
orBec is an oral enteric-coated tablet formulation of the corticosteroid beclometasone, which has been developed by Enteron Pharmaceuticals, a subsidiary of Corporate Technology Development (now DOR BioPharma). orBec is being developed for the treatment of gastrointestinal graft-versus-host disease (GVHD) and an NDA has been filed in the US. DOR BioPharma has also filed an MAA in Europe for the same indication.orBec is designed to reduce the need for systemic immunosuppressive drugs, thereby improving the outcome of bone marrow and stem cell transplantation.DOR BioPharma may seek a marketing partner in the US and elsewhere for orBec in GVHD and will seek a partner for other potential indications of the drug.In December 2001, Corporate Technology Development was acquired by Endorex Corporation (now DOR BioPharma). In October 1998, Enteron Pharmaceuticals (DOR BioPharma) entered into an exclusive, worldwide, royalty bearing license agreement with George B. McDonald, MD, including the right to grant sublicenses, for the rights to the intellectual property and know-how relating to orBec. In January 2007, DOR BioPharma received $US3 million under a non-binding letter of intent from Sigma-Tau Pharmaceuticals. The agreement grants Sigma-Tau an exclusive right to negotiate terms and conditions for a possible business transaction or strategic alliance regarding orBec and potentially other DOR pipeline compounds until 1 March 2007. Under the terms of the agreement, Sigma-Tau purchased $US1 million of DOR's common stock, with an additional $US2 million paid in cash. If no agreement is reached by 1 March 2007, DOR will return the $US2 million to Sigma-Tau within 60 days. DOR BioPharma received an unsolicited proposal from Cell Therapeutics, Inc. to acquire DOR BioPharma in January 2007. Because of the non-binding agreement already signed with Sigma-Tau, DOR BioPharma's board of directors cannot consider Cell Therapeutics' merger proposal at this time. orBec has been filed for approval in the US for the treatment of gastrointestinal GVHD. The US FDA accepted the NDA filing and has established a target date of 21 July 2007 for completion of review of the NDA. In November 2006, the EMEA determined that the MAA for orBec for the treatment of gastrointestinal GVHD is complete and that the review process has begun. The data provided in the MAA and NDA submissions demonstrate that orBec safely provides a lower risk of mortality compared with the current standard of care. Both filings are supported by data from two randomised, double-blinded, placebo-controlled clinical trials. The first was a 129-patient pivotal phase III clinical trial for orBec conducted at 16 bone marrow/stem cell transplant centres in the US and France. The second trial was a 60-patient phase II clinical trial conducted at the Fred Hutchinson Cancer Research Centre. In the primary endpoint of its pivotal trial, time to treatment failure through day 50, orBec failed to achieve statistical significance (p-value 0.1177). However, orBec did achieve statistical significance in the secondary endpoints of time to treatment failure through day 80, and a reduction in mortality compared with placebo. In this trial, patient survival at the prespecified endpoint of 200 days post-transplant showed a statistically significant 66% reduction in mortality among patients randomised to orBec. DOR BioPharma believes the primary endpoint was not achieved due to a higher than expected rate of treatment failures during the initial 10 days in both treatment groups. The mortality benefit in favour of orBec was confirmed in a retrospective analysis of the phase II study, in which there was a 55% reduction in mortality at 200 days post-transplant. At 1 year after randomisation, there were relatively consistent 51% and 45% reductions in the risk of mortality among patients randomised to orBec in both the phase III and phase II studies, respectively.DOR BioPharma is also conducting a phase II clinical trial to investigate orBec in the prevention of gastrointestinal GVHD. DOR BioPharma has executed an exclusive licence agreement with the University of Texas Medical Branch at Galveston for the use of oral luminally active anti-inflammatory drugs, such as orBec, for the treatment of irritable bowel syndrome.
NASA Astrophysics Data System (ADS)
Liu, Li-Wei; Gengzang, Duo-Jie; An, Xiu-Jia; Wang, Pei-Yu
2018-03-01
We propose a novel technique of generating multiple optomechanically induced transparency (OMIT) of a weak probe field in hybrid optomechanical system. This system consists of a cigar-shaped Bose–Einstein condensate (BEC), trapped inside each high finesse Fabry-Pérot cavity. In the resolved sideband regime, the analytic solutions of the absorption and the dispersion spectrum are given. The tunneling strength of the two resonators and the coupling parameters of the each BEC in combination with the cavity field have the appearance of three distinct OMIT windows in the absorption spectrum. Furthermore, whether there is BEC in each cavity is a key factor in the number of OMIT windows determination. The technique presented may have potential applications in quantum engineering and quantum information networks. Project supported by the National Natural Science Foundation of China (Grant Nos. 11564034, 11105062, and 21663026) and the Scientific Research Funds of College of Electrical Engineering, Northwest University, China (Grant No. xbmuyjrc201115).
JILA BEC/Ultracold Atoms Homepage
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Inequality and mortality: demographic hypotheses regarding advanced and peripheral capitalism.
Gregory, J W; Piché, V
1983-01-01
This paper analyzes mortality differences between social classes and between advanced and peripheral regions of the world economy. The demographic analysis of mortality is integrated with the study of political economy, which emphasizes the entire process of social reproduction. As part of this dialectic model, both the struggle of the working class to improve health and the interest of capital in maximizing profits are examined. Data from Québec and Upper Volta are used to illustrate the hypothesis that substantially higher mortality rates exist for the working class compared with the bourgeoisie and in the less developed peripheral regions compared with the more developed regions.
ERIC Educational Resources Information Center
Richard, Gabrielle; Vallerand, Olivier; Petit, Marie-Pier; Charbonneau, Amélie
2015-01-01
To fight homophobia in schools in Québec, many teachers rely on community organizations such as the Groupe de Recherche et d'Intervention Sociale (Research and Social Intervention Group) to address sexual diversity in class. This article documents major outcomes of these workshops as seen by students. Students identified topics related to…
Investigation of Kibble-Zurek Quench Dynamics in a Spin-1 Ferromagnetic BEC
NASA Astrophysics Data System (ADS)
Anquez, Martin; Robbins, Bryce; Hoang, Thai; Yang, Xiaoyun; Land, Benjamin; Hamley, Christopher; Chapman, Michael
2014-05-01
We study the temporal evolution of spin populations in small spin-1 87Rb condensates following a slow quench. A ferromagnetic spin-1 BEC exhibits a second-order gapless (quantum) phase transition due to a competition between the magnetic and collisional spin interaction energies. The dynamics of slow quenches through the critical point are predicted to exhibit universal power-law scaling as a function of quench speed. In spatially extended condensates, these excitations are revealed as spatial spin domains. In small condensates, the excitations are manifest in the temporal evolution of the spin populations, illustrating a Kibble-Zurek type scaling. We will present the results of our investigation and compare them to full quantum simulations of the system.
Biometrics Enabling Capability Increment 1 (BEC Inc 1)
2016-03-01
2016 Major Automated Information System Annual Report Biometrics Enabling Capability Increment 1 (BEC Inc 1) Defense Acquisition Management...Phone: 227-3119 DSN Fax: Date Assigned: July 15, 2015 Program Information Program Name Biometrics Enabling Capability Increment 1 (BEC Inc 1) DoD...therefore, no Original Estimate has been established. BEC Inc 1 2016 MAR UNCLASSIFIED 4 Program Description The Biometrics Enabling Capability (BEC
Task Accomplishment in an Air Force Maintenance Environment.
1981-02-01
organization theory courses, both graduate and undergr’ad- uate, since coming to Western Carolina University. Dr. Kane is active within the university and...1972, 1963,4) state that the location of the organisms is never unimpnctant or accidental becZause behavior and place concatenate in-to lawful, iiuncti...not a viable approach to co.-mpare extreme behavior wiLhout creating additionol work. First, the hc,-t organization would not permit that; second, the
Schmidt, Sarah M; Kuhn, Hannah; Micali, Cristina; Liller, Corinna; Kwaaitaal, Mark; Panstruga, Ralph
2014-08-01
Filamentous phytopathogens, such as fungi and oomycetes, secrete effector proteins to establish successful interactions with their plant hosts. In contrast with oomycetes, little is known about effector functions in true fungi. We used a bioinformatics pipeline to identify Blumeria effector candidates (BECs) from the obligate biotrophic barley powdery mildew pathogen, Blumeria graminis f. sp. hordei (Bgh). BEC1-BEC5 are expressed at different time points during barley infection. BEC1, BEC2 and BEC4 have orthologues in the Arabidopsis thaliana-infecting powdery mildew fungus Golovinomyces orontii. Arabidopsis lines stably expressing the G. orontii BEC2 orthologue, GoEC2, are more susceptible to infection with the non-adapted fungus Erysiphe pisi, suggesting that GoEC2 contributes to powdery mildew virulence. For BEC3 and BEC4, we identified thiopurine methyltransferase, a ubiquitin-conjugating enzyme, and an ADP ribosylation factor-GTPase-activating protein (ARF-GAP) as potential host targets. Arabidopsis knockout lines of the respective HvARF-GAP orthologue (AtAGD5) allowed higher entry levels of E. pisi, but exhibited elevated resistance to the oomycete Hyaloperonospora arabidopsidis. We hypothesize that ARF-GAP proteins are conserved targets of powdery and downy mildew effectors, and we speculate that BEC4 might interfere with defence-associated host vesicle trafficking. © 2013 BSPP AND JOHN WILEY & SONS LTD.
Jin, Lifang; Ji, Shaohui; Sun, Aijing
2013-06-01
Efficient culture of primary biliary epithelial cells (BECs) from adult liver is useful for both experimental studies and clinical applications of tissue engineering. However, an effective culture system for long-term proliferation of adult BECs is still unachieved. Laboratory rabbit has been used in a large number of studies; however, there are no reports of BECs from normal adult rabbit. As little as 5 g of normal rabbit liver tissue were minced, digested, and then clonally cultured in medium containing FBS and ITS. Cells were characterized by cell morphology, immunoassaying, and growth rate assay. Different combination of growth factors and substrates, including Y-27632 and Matrigel, were employed to assess their effect on cell proliferation. In the primary culture, the BECs cellular sheets consisting of cuboidal cells, as well as fibroblast-like cells and other hepatic cells, emerged with time of culture. The BECs cellular sheets were then manually split into cells clumps for further characterization. The subcultured cells had typical cell morphology of cholangiocytes, expressed the specific markers of BECs, including GGT, cytokeratin (CK18), and CK19, and possessed the capacity to form duct-like structure in three-dimensional Matrigel. Y-27632 and Matrigel-treated BECs had a steady growth rate as well as colony-formation capacity. The BECs were maintained in Y-27632 and Matrigel culture system for more than 3 mo. This is the first example, to our knowledge, of the successful culture of BECs from normal adult rabbit liver. Furthermore, our results indicate that treatment of BECs with Y-27632 and Matrigel is a simple method for efficient output of BECs.
Two genetically distinct bovine enteric caliciviruses (BEC) have been identified: the Norwalk-like-viruses (NLV), which are genetically related to human NLV, and the distinct NB-like BEC, which is most closely related to Sapporo-like viruses and lagoviruses, but potentially may ...
Smart timber bridge on geosynthetic reinforced soil (GRS) abutments
Adam Senalik; James P. Wacker; Travis K. Hosteng; John Hermanson
2017-01-01
Recently, Buchanan County, Iowa, has cooperated with the U.S. Federal Highway Administration (FHWA), USDA Forest Service, Forest Products Laboratory (FPL), and Iowa State Universityâs Bridge Engineering Center (ISUâBEC) to initiate a project involving the construction and monitoring of a glued-laminated (glulam) timber superstructure on geosynthetic reinforced soil (...
Ginzburg-Landau expansion in strongly disordered attractive Anderson-Hubbard model
NASA Astrophysics Data System (ADS)
Kuchinskii, E. Z.; Kuleeva, N. A.; Sadovskii, M. V.
2017-07-01
We have studied disordering effects on the coefficients of Ginzburg-Landau expansion in powers of superconducting order parameter in the attractive Anderson-Hubbard model within the generalized DMFT+Σ approximation. We consider the wide region of attractive potentials U from the weak coupling region, where superconductivity is described by BCS model, to the strong coupling region, where the superconducting transition is related with Bose-Einstein condensation (BEC) of compact Cooper pairs formed at temperatures essentially larger than the temperature of superconducting transition, and a wide range of disorder—from weak to strong, where the system is in the vicinity of Anderson transition. In the case of semielliptic bare density of states, disorder's influence upon the coefficients A and B of the square and the fourth power of the order parameter is universal for any value of electron correlation and is related only to the general disorder widening of the bare band (generalized Anderson theorem). Such universality is absent for the gradient term expansion coefficient C. In the usual theory of "dirty" superconductors, the C coefficient drops with the growth of disorder. In the limit of strong disorder in BCS limit, the coefficient C is very sensitive to the effects of Anderson localization, which lead to its further drop with disorder growth up to the region of the Anderson insulator. In the region of BCS-BEC crossover and in BEC limit, the coefficient C and all related physical properties are weakly dependent on disorder. In particular, this leads to relatively weak disorder dependence of both penetration depth and coherence lengths, as well as of related slope of the upper critical magnetic field at superconducting transition, in the region of very strong coupling.
Analyses of Third Order Bose-Einstein Correlation by Means of Coulomb Wave Function
DOE Office of Scientific and Technical Information (OSTI.GOV)
Biyajima, Minoru; Mizoguchi, Takuya; Suzuki, Naomichi
2006-04-11
In order to include a correction by the Coulomb interaction in Bose-Einstein correlation (BEC), the wave function for the Coulomb scattering were introduced in the quantum optical approach to BEC in the previous work. If we formulate the amplitude written by Coulomb wave functions according to the diagram for BEC in the plane wave formulation, the formula for 3{pi} -BEC becomes simpler than that of our previous work. We re-analyze the raw data of 3{pi} -BEC by NA44 and STAR Collaborations by this formula. Results are compared with the previous ones.
Santa Cruz, Vicente; Liu, Hanlin; Kaphalia, Lata; Kanz, Mary F.
2007-01-01
Methylenedianiline (DAPM) is considered a cholangiodestructive toxicant in vivo. Increases in biliary inorganic phosphate (Pi) and glucose occur prior to biliary epithelial cell (BEC) injury, which could be due to increased paracellular permeability and/or impairment of Pi and glucose uptake by BEC. To evaluate these possibilities, we induced mild injury [loss of BEC from major bile ducts (6 h), ultrastructural alterations in BEC mitochondria and Golgi cisternae (3 h), and striking increases in biliary Pi and glucose (3–6 h)] with 25 mg DAPM/kg and then assessed temporal alterations in tight junction (TJ) permeability by measuring bile to plasma (B:P) ratios of [3H]-inulin. Parameters maintained by hepatocytes in bile were unchanged (bile flow, bile acids, bilirubin) or only transiently perturbed (protein, glutathione). Minimal elevations in B:P ratios of inulin occurred temporally later (4 h) in DAPM-treated rats than increases in biliary Pi and glucose. To confirm a direct effect of DAPM on BEC TJs, we measured transepithelial resistance (TER) and bi-ionic potentials of BEC monolayers prior to and after exposure to pooled (4 to 6) bile samples collected from untreated rats (Basal Bile) or rats treated with 50 mg DAPM/ kg (DAPM-Bile). BEC TJs were found to be cation selective. Exposure to DAPM-Bile for 1 h decreased TERs by ~35% and decreased charge selectivity of BEC TJs while exposure to Basal Bile had no effects. These observations indicate that DAPM-Bile impairs paracellular permeability of BEC in vitro. Further, our in vivo model suggests that increases in paracellular permeability induced by DAPM are localized to BEC because bile flow and constituents excreted by hepatocytes were unchanged; BEC damage was temporally correlated with increases in biliary Pi and glucose; and elevations in B:P ratios of inulin were delayed and minimal. PMID:17178199
Preterm birth in the Inuit and First Nations populations of Québec, Canada, 1981-2008.
Auger, Nathalie; Fon Sing, Mélanie; Park, Alison L; Lo, Ernest; Trempe, Normand; Luo, Zhong-Cheng
2012-03-24
To evaluate preterm birth (PTB) for Inuit and First Nations vs. non-Indigenous populations in the province of Québec, Canada. Retrospective cohort study. We evaluated singleton live births for Québec residents, 1981-2008 (n = 2,310,466). Municipality of residence (Inuit-inhabited, First Nations-inhabited, rest of Québec) and language (Inuit, First Nations, French/English) were used to identify Inuit and First Nations births. The outcome was PTB (<37 completed weeks). Cox proportional hazards regression was employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) of PTB, adjusting for maternal age, education, marital status, parity and birth year. PTB rates were higher for Inuit language speakers in Inuit-inhabited areas and the rest of Québec compared with French/English speakers in the rest of Québec, and disparities persisted over time. Relative to French/English speakers in the rest of Québec, Inuit language speakers in the rest of Québec had the highest risk of PTB (HR 1.98, 95% CI: 1.62-2.41). The risk was also elevated for Inuit language speakers in Inuit-inhabited areas, though to a lesser extent (HR 1.29, 95% CI: 1.18-1.41). In contrast, First Nations language speakers in First Nations-inhabited areas and the rest of Québec had similar or lower risks of PTB relative to French/English speakers in the rest of Québec. Inuit populations, especially those outside Inuit-inhabited areas, have persistently elevated risks of PTB, indicating a need for strategies to prevent PTB in this population.
Preterm birth in the Inuit and First Nations populations of Québec, Canada, 1981–2008
Auger, Nathalie; Sing, Mélanie Fon; Park, Alison L.; Lo, Ernest; Trempe, Normand; Luo, Zhong-Cheng
2012-01-01
Objectives To evaluate preterm birth (PTB) for Inuit and First Nations vs. non-Indigenous populations in the province of Québec, Canada. Study design Retrospective cohort study. Methods We evaluated singleton live births for Québec residents, 1981–2008 (n =2,310,466). Municipality of residence (Inuit-inhabited, First Nations-inhabited, rest of Québec) and language (Inuit, First Nations, French/English) were used to identify Inuit and First Nations births. The outcome was PTB (<37 completed weeks). Cox proportional hazards regression was employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) of PTB, adjusting for maternal age, education, marital status, parity and birth year. Results PTB rates were higher for Inuit language speakers in Inuit-inhabited areas and the rest of Québec compared with French/English speakers in the rest of Québec, and disparities persisted over time. Relative to French/English speakers in the rest of Québec, Inuit language speakers in the rest of Québec had the highest risk of PTB (HR 1.98, 95% CI: 1.62–2.41). The risk was also elevated for Inuit language speakers in Inuit-inhabited areas, though to a lesser extent (HR 1.29, 95% CI: 1.18–1.41). In contrast, First Nations language speakers in First Nations-inhabited areas and the rest of Québec had similar or lower risks of PTB relative to French/English speakers in the rest of Québec. Conclusions Inuit populations, especially those outside Inuit-inhabited areas, have persistently elevated risks of PTB, indicating a need for strategies to prevent PTB in this population. PMID:22456035
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kira, M., E-mail: mackillo.kira@physik.uni-marburg.de
Atomic Bose–Einstein condensates (BECs) can be viewed as macroscopic objects where atoms form correlated atom clusters to all orders. Therefore, the presence of a BEC makes the direct use of the cluster-expansion approach–lucrative e.g. in semiconductor quantum optics–inefficient when solving the many-body kinetics of a strongly interacting Bose. An excitation picture is introduced with a nonunitary transformation that describes the system in terms of atom clusters within the normal component alone. The nontrivial properties of this transformation are systematically studied, which yields a cluster-expansion friendly formalism for a strongly interacting Bose gas. Its connections and corrections to the standard Hartree–Fock–Bogoliubov approachmore » are discussed and the role of the order parameter and the Bogoliubov excitations are identified. The resulting interaction effects are shown to visibly modify number fluctuations of the BEC. Even when the BEC has a nearly perfect second-order coherence, the BEC number fluctuations can still resolve interaction-generated non-Poissonian fluctuations. - Highlights: • Excitation picture expresses interacting Bose gas with few atom clusters. • Semiconductor and BEC many-body investigations are connected with cluster expansion. • Quantum statistics of BEC is identified in terms of atom clusters. • BEC number fluctuations show extreme sensitivity to many-body correlations. • Cluster-expansion friendly framework is established for an interacting Bose gas.« less
Haine, Denis; Delgado, Hector; Cue, Roger; Sewalem, Asheber; Wade, Kevin; Lacroix, René; Lefebvre, Daniel; Arsenault, Julie; Bouchard, Émile; Dubuc, Jocelyn
2017-09-01
Several health disorders, such as milk fever, displaced abomasum, and mastitis, as well as impaired reproductive performance, are known risk factors for the removal of affected cows from a dairy herd. While cow-level risk factors are well documented in the literature, herd-level associations have been less frequently investigated. The objective of this study was to investigate the effect of cow- and herd-level determinants on variations in culling risk in Québec dairy herds: whether herd influences a cow's culling risk. For this, we assessed the influence of herd membership on cow culling risk according to displaced abomasum, milk fever, and retained placenta. A retrospective longitudinal study was conducted on data from dairy herds in the Province of Québec, Canada, by extracting health information events from the dairy herd health management software used by most Québec dairy producers and their veterinarians. Data were extracted for all lactations starting between January 1st and December 31st, 2010. Using multilevel logistic regression, we analysed a total of 10,529 cows from 201 herds that met the inclusion criteria. Milk fever and displaced abomasum were demonstrated to increase the cow culling risk. A minor general herd effect was found for the culling risk (i.e. an intra-class correlation of 1.0% and median odds ratio [MOR] of 1.20). The proportion of first lactation cows was responsible for this significant, but weak herd effect on individual cow culling risk, after taking into account the cow-level factors. On the other hand, the herd's average milk production was a protective factor. The planning and management of forthcoming replacement animals has to be taken into consideration when assessing cow culling risks and herd culling rates. Copyright © 2017 Elsevier B.V. All rights reserved.
Comparison of different pairing fluctuation approaches to BCS-BEC crossover
DOE Office of Scientific and Technical Information (OSTI.GOV)
Levin, Kathryn; Chen Qijin; Zhejiang Institute of Modern Physics and Department of Physics, Zhejiang University, Hangzhou, Zhejiang 310027
2010-02-15
The subject of BCS-Bose-Einstein condensation (BEC) crossover is particularly exciting because of its realization in ultracold atomic Fermi gases and its possible relevance to high temperature superconductors. In this paper we review the body of theoretical work on this subject, which represents a natural extension of the seminal papers by Leggett and by Nozieres and Schmitt-Rink (NSR). The former addressed only the ground state, now known as the 'BCS-Leggett' wave-function, and the key contributions of the latter pertain to calculations of the superfluid transition temperature T{sub c}. These two papers have given rise to two main and, importantly, distinct, theoreticalmore » schools in the BCS-BEC crossover literature. The first of these extends the BCS-Leggett ground state to finite temperature and the second extends the NSR scheme away from T{sub c} both in the superfluid and normal phases. It is now rather widely accepted that these extensions of NSR produce a different ground state than that first introduced by Leggett. This observation provides a central motivation for the present paper which seeks to clarify the distinctions in the two approaches. Our analysis shows how the NSR-based approach views the bosonic contributions more completely but treats the fermions as 'quasi-free'. By contrast, the BCS-Leggett based approach treats the fermionic contributions more completely but treats the bosons as 'quasi-free'. In a related fashion, the NSR-based schemes approach the crossover between BCS and BEC by starting from the BEC limit and the BCS-Leggett based scheme approaches this crossover by starting from the BCS limit. Ultimately, one would like to combine these two schemes. There are, however, many difficult problems to surmount in any attempt to bridge the gap in the two theory classes. In this paper we review the strengths and weaknesses of both approaches. The flexibility of the BCS-Leggett based approach and its ease of handling make it widely used in T=0 applications, although the NSR-based schemes tend to be widely used at T{ne}0. To reach a full understanding, it is important in the future to invest effort in investigating in more detail the T=0 aspects of NSR-based theory and at the same time the T{ne}0 aspects of BCS-Leggett theory.« less
From polariton condensates to highly photonic quantum degenerate states of bosonic matter
Aßmann, Marc; Tempel, Jean-Sebastian; Veit, Franziska; Bayer, Manfred; Rahimi-Iman, Arash; Löffler, Andreas; Höfling, Sven; Reitzenstein, Stephan; Worschech, Lukas; Forchel, Alfred
2011-01-01
Bose–Einstein condensation (BEC) is a thermodynamic phase transition of an interacting Bose gas. Its key signatures are remarkable quantum effects like superfluidity and a phonon-like Bogoliubov excitation spectrum, which have been verified for atomic BECs. In the solid state, BEC of exciton–polaritons has been reported. Polaritons are strongly coupled light-matter quasiparticles in semiconductor microcavities and composite bosons. However, they are subject to dephasing and decay and need external pumping to reach a steady state. Accordingly the polariton BEC is a nonequilibrium process of a degenerate polariton gas in self-equilibrium, but out of equilibrium with the baths it is coupled to and therefore deviates from the thermodynamic phase transition seen in atomic BECs. Here we show that key signatures of BEC can even be observed without fulfilling the self-equilibrium condition in a highly photonic quantum degenerate nonequilibrium system. PMID:21245353
Yonogi, Shinya; Kanki, Masashi; Ohnishi, Takahiro; Shiono, Masami; Iida, Tetsuya; Kumeda, Yuko
2016-08-01
Clostridium perfringens causes food-borne gastroenteritis following the consumption of contaminated food by producing C. perfringens enterotoxin (CPE) in the intestines. Recently, we reported a novel enterotoxin, binary enterotoxin of C. perfringens (BEC) in C. perfringens isolates, which caused two disease outbreaks in Japan. Consequently, in the event of food poisoning outbreaks caused by C. perfringens, it is now necessary to screen for both the cpe and becAB genes by diagnostic PCR. Here, we present a simple multiplex PCR method for simultaneous detection of cpe, becAB and a C. perfringens control locus, phospholipase C (plc). Applying this method, we investigated the prevalence of cpe- or becAB-carrying C. perfringens strains in human stool and bovine rectum swab samples. Using a total of 169 isolates, we found that the percentage of becAB-carrying strains was very small (0.59%), one-tenth that of cpe-carrying strains. The simple method presented in this study with high specificity and sensitivity to C. perfringens will be a useful tool to survey the global prevalence of becAB-carrying C. perfringens strains. Copyright © 2016 Elsevier B.V. All rights reserved.
Fast machine-learning online optimization of ultra-cold-atom experiments.
Wigley, P B; Everitt, P J; van den Hengel, A; Bastian, J W; Sooriyabandara, M A; McDonald, G D; Hardman, K S; Quinlivan, C D; Manju, P; Kuhn, C C N; Petersen, I R; Luiten, A N; Hope, J J; Robins, N P; Hush, M R
2016-05-16
We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates (BEC). BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our 'learner' discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system.
Fast machine-learning online optimization of ultra-cold-atom experiments
Wigley, P. B.; Everitt, P. J.; van den Hengel, A.; Bastian, J. W.; Sooriyabandara, M. A.; McDonald, G. D.; Hardman, K. S.; Quinlivan, C. D.; Manju, P.; Kuhn, C. C. N.; Petersen, I. R.; Luiten, A. N.; Hope, J. J.; Robins, N. P.; Hush, M. R.
2016-01-01
We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates (BEC). BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our ‘learner’ discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system. PMID:27180805
Magnon condensation and spin superfluidity
NASA Astrophysics Data System (ADS)
Bunkov, Yury M.; Safonov, Vladimir L.
2018-04-01
We consider the Bose-Einstein condensation (BEC) of quasi-equilibrium magnons which leads to spin superfluidity, the coherent quantum transfer of magnetization in magnetic material. The critical conditions for excited magnon density in ferro- and antiferromagnets, bulk and thin films, are estimated and discussed. It was demonstrated that only the highly populated region of the spectrum is responsible for the emergence of any BEC. This finding substantially simplifies the BEC theoretical analysis and is surely to be used for simulations. It is shown that the conditions of magnon BEC in the perpendicular magnetized YIG thin film is fulfillied at small angle, when signals are treated as excited spin waves. We also predict that the magnon BEC should occur in the antiferromagnetic hematite at room temperature at much lower excited magnon density compared to that of ferromagnetic YIG. Bogoliubov's theory of Bose-Einstein condensate is generalized to the case of multi-particle interactions. The six-magnon repulsive interaction may be responsible for the BEC stability in ferro- and antiferromagnets where the four-magnon interaction is attractive.
Collision of impurities with Bose–Einstein condensates
NASA Astrophysics Data System (ADS)
Lingua, F.; Lepori, L.; Minardi, F.; Penna, V.; Salasnich, L.
2018-04-01
Quantum dynamics of impurities in a bath of bosons is a long-standing problem in solid-state, plasma, and atomic physics. Recent experimental and theoretical investigations with ultracold atoms have focused on this problem, studying atomic impurities immersed in an atomic Bose–Einstein condensate (BEC) and for various relative coupling strengths tuned by the Fano‑Feshbach resonance technique. Here, we report extensive numerical simulations on a closely related problem: the collision between a bosonic impurity consisting of a few 41K atoms and a BEC of 87Rb atoms in a quasi one-dimensional configuration and under a weak harmonic axial confinement. For small values of the inter-species interaction strength (regardless of its sign), we find that the impurity, which starts from outside the BEC, simply causes the BEC cloud to oscillate back and forth, but the frequency of oscillation depends on the interaction strength. For intermediate couplings, after a few cycles of oscillation the impurity is captured by the BEC, and strongly changes its amplitude of oscillation. In the strong interaction regime, if the inter-species interaction is attractive, a local maximum (bright soliton) in the BEC density occurs where the impurity is trapped; if, instead, the inter-species interaction is repulsive, the impurity is not able to enter the BEC cloud and the reflection coefficient is close to one. However, if the initial displacement of the impurity is increased, the impurity is able to penetrate the cloud, leading to the appearance of a moving hole (dark soliton) in the BEC.
Quantum fluctuations in the BCS-BEC crossover of two-dimensional Fermi gases
DOE Office of Scientific and Technical Information (OSTI.GOV)
He, Lianyi; Lu, Haifeng; Cao, Gaoqing
2015-08-14
We present a theoretical study of the ground state of the BCS-BEC crossover in dilute two-dimensional Fermi gases. While the mean-field theory provides a simple and analytical equation of state, the pressure is equal to that of a noninteracting Fermi gas in the entire BCS-BEC crossover, which is not consistent with the features of a weakly interacting Bose condensate in the BEC limit and a weakly interacting Fermi liquid in the BCS limit. The inadequacy of the two-dimensional mean-field theory indicates that the quantum fluctuations are much more pronounced than those in three dimensions. In this work, we show thatmore » the inclusion of the Gaussian quantum fluctuations naturally recovers the above features in both the BEC and the BCS limits. In the BEC limit, the missing logarithmic dependence on the boson chemical potential is recovered by the quantum fluctuations. Near the quantum phase transition from the vacuum to the BEC phase, we compare our equation of state with the known grand canonical equation of state of two-dimensional Bose gases and determine the ratio of the composite boson scattering length a B to the fermion scattering length a 2D. We find a B ≃ 0.56a 2D, in good agreement with the exact four-body calculation. As a result, we compare our equation of state in the BCS-BEC crossover with recent results from the quantum Monte Carlo simulations and the experimental measurements and find good agreements.« less
Epidemiologic studies have linked exposures to particulate matter (PM) and increased pulmonary mortality and morbidity. Bronchial epithelial cells (BEC) are the primary target of PM. PM exposure induces a wide array of biological responses in BEC. Primary human BEC, however, need...
Influence of silicon oxide on the performance of TiN bottom electrode in phase change memory
NASA Astrophysics Data System (ADS)
Gao, Dan; Liu, Bo; Xu, Zhen; Wang, Heng; Xia, Yangyang; Wang, Lei; Zhu, Nanfei; Li, Ying; Zhan, Yipeng; Song, Zhitang; Feng, Songlin
2016-10-01
The stability of TiN which is the preferred bottom electrode contact (BEC) of phase change memory (PCM) due to its low thermal conductivity and suitable electrical conductivity, is very essential to the reliability of PCM devices. In this work, in order to investigate the effect of high aspect ratio process (HARP) SiO2 on the performance of TiN, both TiN/SiO2, TiN/SiN thin films and TiN BEC device structures are analyzed. By combining transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS), we found that the TiN would be oxidized after the deposition of HARP SiO2 and there exist a thin ( 4 nm) oxidation interfacial layer between TiN and SiO2. Electrical measurements were performed on the 1R PCM test-key die with 7 nm and 10 nm BEC-only cells. The statistical initial resistances of BEC have wide distribution and it is confirmed that the non-uniform oxidation of TiN BEC affects the astringency of the resistance of TiN BEC. The experimental results help to optimize the process of TiN BEC, and SiN is recommended as a better choice as the linear layer.
Modulated amplitude waves in collisionally inhomogeneous Bose Einstein condensates
NASA Astrophysics Data System (ADS)
Porter, Mason A.; Kevrekidis, P. G.; Malomed, Boris A.; Frantzeskakis, D. J.
2007-05-01
We investigate the dynamics of an effectively one-dimensional Bose-Einstein condensate (BEC) with scattering length a subjected to a spatially periodic modulation, a=a(x)=a(x+L). This “collisionally inhomogeneous” BEC is described by a Gross-Pitaevskii (GP) equation whose nonlinearity coefficient is a periodic function of x. We transform this equation into a GP equation with a constant coefficient and an additional effective potential and study a class of extended wave solutions of the transformed equation. For weak underlying inhomogeneity, the effective potential takes a form resembling a superlattice, and the amplitude dynamics of the solutions of the constant-coefficient GP equation obey a nonlinear generalization of the Ince equation. In the small-amplitude limit, we use averaging to construct analytical solutions for modulated amplitude waves (MAWs), whose stability we subsequently examine using both numerical simulations of the original GP equation and fixed-point computations with the MAWs as numerically exact solutions. We show that “on-site” solutions, whose maxima correspond to maxima of a(x), are more robust and likely to be observed than their “off-site” counterparts.
Sawada, Seiko; Harada, Kenichi; Isse, Kumiko; Sato, Yasunori; Sasaki, Motoko; Kaizaki, Yasuharu; Nakanuma, Yasuni
2007-10-01
Xanthogranulomatous cholecystitis (XGC) is characterized by the infiltration of numerous foamy macrophages. Bacterial infection is thought to be involved in the pathogenesis of XGC. Using XGC and cultured murine biliary epithelial cells (BEC), the participation of E. coli and the role of the scavenger receptor class A (SCARA), as well as chemokine(C-X-C motif) ligand 16 (CXCL16) and its receptor chemokine(C-X-C motif) receptor 6 (CXCR6), were examined in the pathogenesis of XGC. E. coli components and genes were detected in XGC on immunohistochemistry and polymerase chain reaction (PCR), respectively. SCARA-recognizing E. coli was found in foamy macrophages aggregated in xanthogranulomatous lesions. CXCL16, which functions as a membrane-bound molecule and soluble chemokine to induce adhesion and migration of CXCR6(+) cells, was detected on gallbladder epithelia, and CXCR6(+)/CD8(+) T cells and CXCR6(+)/CD68(+) macrophages were also accumulated. In cultured BEC, CXCL16 mRNA and secreted soluble CXCL16 were constantly detected and upregulated by treatment with E. coli and lipopolysaccharide through Toll-like receptor 4. These suggest that SCARA in macrophages is involved in the phagocytosis of E. coli followed by foamy changes and that bacterial infection causes the upregulation of CXCL16 in gallbladder epithelia, leading to the chemoattraction of macrophages via CXCL16-CXCR6 interaction and formation of the characteristic histology of XGC.
ERIC Educational Resources Information Center
Walsh, Jennifer R.; Hebert, Angel; Byrd-Bredbenner, Carol; Carey, Gale; Colby, Sarah; Brown-Esters, Onikia N.; Greene, Geoffrey; Hoerr, Sharon; Horacek, Tanya; Kattelmann, Kendra; Kidd, Tandalayo; Koenings, Mallory; Phillips, Beatrice; Shelnutt, Karla P.; White, Adrienne A.
2012-01-01
Objective: To develop and test the validity of the Behavior, Environment, and Changeability Survey (BECS) for identifying the importance and changeability of nutrition, exercise, and stress management behavior and related aspects of the environment. Design: A cross-sectional, online survey of the BECS and selected validated instruments. Setting:…
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-07
... Alberta Investment Management Corporation, Caisse de d[eacute]p[ocirc]t et placement du Qu[eacute]bec... Capital Markets Inc., Fonds de solidarit[eacute] des travailleurs du Qu[eacute]bec (F.T.Q.), GMP Capital... (Qu[eacute]bec), Alberta Securities Commission, British Columbia Securities Commission, Competition...
Bose-Einstein Condensates in 1D Optical Lattices: Nonlinearity and Wannier-Stark Spectra
NASA Astrophysics Data System (ADS)
Arimondo, Ennio; Ciampini, Donatella; Morsch, Oliver
The development of powerful laser cooling and trapping techniques has made possible the controlled realization of dense and cold gaseous samples, thus opening the way for investigations in the ultracold temperature regimes not accessible with conventional techniques. A Bose-Einstein condensate (BEC) represents a peculiar gaseous state where all the particles reside in the same quantum mechanical state. Therefore BECs exhibit quantum mechanical phe-nomena on a macroscopic scale with a single quantum mechanical wavefunction describing the external degrees of freedom. That control of the external degrees of freedom is combined with a precise control of the internal degrees. The BEC investigation has become a very active area of research in contem-porary physics. The BEC study encompasses different subfields of physics, i.e., atomic and molecular physics, quantum optics, laser spectroscopy, solid state physics. Atomic physics and laser spectroscopy provide the methods for creating and manipulating the atomic and molecular BECs. However owing to the interactions between the particles composing the condensate and to the configuration of the external potential, concepts and methods from solid state physics are extensively used for BEC description.
Hidden multiparticle excitation in a weakly interacting Bose-Einstein condensate
NASA Astrophysics Data System (ADS)
Watabe, Shohei
2018-03-01
We investigate multiparticle excitation effect on a collective density excitation as well as a single-particle excitation in a weakly interacting Bose-Einstein condensate (BEC). We find that although the weakly interacting BEC offers weak multiparticle excitation spectrum at low temperatures, this multiparticle excitation effect may not remain hidden, but emerges as bimodality in the density response function through the single-particle excitation. Identification of spectra in the BEC between the single-particle excitation and the density excitation is also assessed at nonzero temperatures, which has been known to be unique nature in the BEC at absolute zero temperature.
Cooling of a Bose-Einstein Condensate by Spin Distillation.
Naylor, B; Maréchal, E; Huckans, J; Gorceix, O; Pedri, P; Vernac, L; Laburthe-Tolra, B
2015-12-11
We propose and experimentally demonstrate a new cooling mechanism leading to purification of a Bose-Einstein condensate (BEC). Our scheme starts with a BEC polarized in the lowest energy spin state. Spin excited states are thermally populated by lowering the single particle energy gap set by the magnetic field. Then, these spin-excited thermal components are filtered out, which leads to an increase of the BEC fraction. We experimentally demonstrate such cooling for a spin 3 ^{52}Cr dipolar BEC. Our scheme should be applicable to Na or Rb, with the perspective to reach temperatures below 1 nK.
Gagnon, Bruno; Nadeau, Lyne; Scott, Susan; Dumont, Serge; MacDonald, Neil; Aubin, Michèle; Mayo, Nancy
2015-07-01
In Canada, governments have increased spending on home care to promote better end-of-life care. In the province of Québec, Canada, home palliative care (PC) services (HPCS) are provided by Public Local Community-Based Health Care Service providers (Centres Locaux de Services Communautaires [CLSC]) with universal coverage. Accordingly, there should be no regional variations of these services and their effect on quality of end-of-life PC (QEoLPC) indicators. To test if all the CLSCs provided the same level of HPCS to cancer patients in the province of Québec, Canada, and the association between level of HPCS and QEoLPC indicators. Characteristics of 52,316 decedents with cancer were extracted from administrative databases between 2003 and 2006. Two gender-specific "adjusted performance of CLSCs in delivering HPCS" models were created using gender-specific hierarchical regression adjusted for patient and CLSC neighborhood characteristics. Using the same approach, the strength of the association between the adjusted performance of CLSCs in delivering HPCS and the QEoLPC indicators was estimated. Overall, 27,255 (52.1%) decedents had at least one HPCS. Significant variations in the adjusted performance of CLSC in delivering HPCS were found. Higher performance led to a lower proportion of men having more than one emergency room visit during the last month of life (risk ratio [RR] 0.924; 95% CI 0.867-0.985), and for women, a higher proportion dying at home (RR 2.255; 95% CI 1.703-2.984) and spending less time in hospital (RR 0.765; 95% CI 0.692-0.845). Provision of HPCS remained limited in Québec, but when present, they were associated with improved QEoLPC indicators. Copyright © 2015 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
Otieno, Monicah A; Bhaskaran, Vasanthi; Janovitz, Evan; Callejas, Yimer; Foster, William B; Washburn, William; Megill, John R; Lehman-McKeeman, Lois; Gemzik, Brian
2017-02-01
The objective of this work was to investigate the mechanisms of hepatobiliary toxicity caused by thienopyrimidone MCHR1 antagonists using BMS-773174 as a tool molecule. Co-administration of the pan CYP inhibitor 1-aminobenzotriazole with BMS-773174 prevented hepatobiliary damage, and direct delivery of the diol metabolite BMS-769750 caused hepatobiliary toxicity, identifying the diol and possibly its downstream hydroxyacid (BMS-800754) metabolite as the toxic species. Rat liver gene expression revealed treatment-related changes in hepatic transporters and induction of oval cell-specific genes including deleted malignant tumor 1 (Dmbt1). The metabolites did not alter hepatic transporter activities, suggesting that transporter-mediated cholestasis was not involved. Because injury to biliary epithelium can result in adaptive hyperplasia, rat biliary epithelial cells (BECs) were isolated and exposed to the oxidative metabolites. BMS-769750 was cytotoxic to BECs, but not rat hepatocytes, suggesting a role of the diol in biliary epithelial injury. BMS-800754 was cytotoxic to rat hepatocytes therefore its contribution to hepatocyte injury in rats is a possibility. Induction of Dmbt1 in rat BECs was investigated because of its role in hepatic progenitor cell differentiation/proliferation during injury. Dmbt1 mRNA was induced by BMS-769750, but not BMS-800754 in BECs; this induction and cellular injury was confirmed with diol metabolites formed by other compounds with the same hepatobiliary liability. In conclusion, hepatobiliary injury by thienopyrimidinone MCHR1 antagonists was driven through a CYP-mediated bioactivation pathway. Induction of Dmbt1 mRNA coupled with cellular injury suggests that injury of biliary epithelium may be the first step toward an adaptive proliferative response causing BDH by these compounds. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Educational Reevaluation, Political Transformation: Québec and Higher Education
ERIC Educational Resources Information Center
Unger, Zoe
2013-01-01
This paper considers the history of Québec's higher education system and the reforms that have contributed to the role of education in the province. Québec's education system has repeatedly been a site for social and political transformation; most recently, reevaluation of education's role in the province has revealed a tension between…
Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration.
Ko, Sungjin; Choi, Tae-Young; Russell, Jacquelyn O; So, Juhoon; Monga, Satdarshan P S; Shin, Donghun
2016-02-01
During liver regeneration, hepatocytes are derived from pre-existing hepatocytes. However, if hepatocyte proliferation is compromised, biliary epithelial cells (BECs) become the source of new hepatocytes. We recently reported on a zebrafish liver regeneration model in which BECs extensively contribute to hepatocytes. Using this model, we performed a targeted chemical screen to identify important factors that regulate BEC-driven liver regeneration, the mechanisms of which remain largely unknown. Using Tg(fabp10a:CFP-NTR) zebrafish, we examined the effects of 44 selected compounds on BEC-driven liver regeneration. Liver size was assessed by fabp10a:DsRed expression; liver marker expression was analyzed by immunostaining, in situ hybridization and quantitative PCR. Proliferation and apoptosis were also examined. Moreover, we used a mouse liver injury model, choline-deficient, ethionine-supplemented (CDE) diet. We identified 10 compounds that affected regenerating liver size. Among them, only bromodomain and extraterminal domain (BET) inhibitors, JQ1 and iBET151, blocked both Prox1 and Hnf4a induction in BECs. BET inhibition during hepatocyte ablation blocked BEC dedifferentiation into hepatoblast-like cells (HB-LCs). Intriguingly, after JQ1 washout, liver regeneration resumed, indicating temporal, but not permanent, perturbation of liver regeneration by BET inhibition. BET inhibition after hepatocyte ablation suppressed the proliferation of newly generated hepatocytes and delayed hepatocyte maturation. Importantly, Myca overexpression, in part, rescued the proliferation defect. Furthermore, oval cell numbers in mice fed CDE diet were greatly reduced upon JQ1 administration, supporting the zebrafish findings. BET proteins regulate BEC-driven liver regeneration at multiple steps: BEC dedifferentiation, HB-LC proliferation, the proliferation of newly generated hepatocytes, and hepatocyte maturation. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Mueller, Tobias; Beutler, Claudia; Picó, Almudena Hurtado; Shibolet, Oren; Pratt, Daniel S; Pascher, Andreas; Neuhaus, Peter; Wiedenmann, Bertram; Berg, Thomas; Podolsky, Daniel K
2011-11-01
Pattern recognition receptors (PRRs) orchestrate the innate immune defence in human biliary epithelial cells (BECs). Tight control of PRR signalling provides tolerance to physiological amounts of intestinal endotoxins in human bile to avoid constant innate immune activation in BECs. We wanted to determine whether inappropriate innate immune responses to intestinal endotoxins contribute to the development and perpetuation of chronic biliary inflammation. We examined PRR-mediated innate immune responses and protective endotoxin tolerance in primary BECs isolated from patients with primary sclerosing cholangitis (PSC), alcoholic liver disease and patients without chronic liver disease. Expression studies comprised northern blots, RT-PCR, Western blots and immunocytochemistry. Functional studies comprised immuno-precipitation Western blots, FACS for endotoxin uptake, and NF-κB activation assays and ELISA for secreted IL-8 and tumour necrosis factor (TNF)-α. Primary BECs from explanted PSC livers showed reversibly increased TLR and NOD protein expression and activation of the MyD88/IRAK signalling complex. Consecutively, PSC BECs exhibited inappropriate innate immune responses to endotoxins and did not develop immune tolerance after repeated endotoxin exposures. This endotoxin hyper-responsiveness was probably because of the stimulatory effect of abundantly expressed IFN-γ and TNF-α in PSC livers, which stimulated TLR4-mediated endotoxin signalling in BECs, leading to increased TLR4-mediated endotoxin incorporation and impaired inactivation of the TLR4 signalling cascade. As TNF-α inhibition partly restored protective innate immune tolerance, endogenous TNF-α secretion probably contributed to inappropriate endotoxin responses in BECs. Inappropriate innate immune responses to intestinal endotoxins and subsequent endotoxin intolerance because of enhanced PRR signalling in BECs probably contribute to chronic cholangitis. © 2011 John Wiley & Sons A/S.
Tomizawa, Yutaka; Iyer, Prasad G; Wongkeesong, Louis M; Buttar, Navtej S; Lutzke, Lori S; Wu, Tsung-Teh; Wang, Kenneth K
2013-01-01
AIM: To investigate a classification of endocytoscopy (ECS) images in Barrett’s esophagus (BE) and evaluate its diagnostic performance and interobserver variability. METHODS: ECS was applied to surveillance endoscopic mucosal resection (EMR) specimens of BE ex-vivo. The mucosal surface of specimen was stained with 1% methylene blue and surveyed with a catheter-type endocytoscope. We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation. The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS. RESULTS: Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures (two images per each classification) into one of four histopathologic categories as follows: (1) BEC1-squamous epithelium; (2) BEC2-BE without dysplasia; (3) BEC3-BE with dysplasia; and (4) BEC4-esophageal adenocarcinoma (EAC) in BE. Accuracy of diagnosis in staff physicians and clinical fellows were, respectively, 100% and 99.4% for BEC1, 95.8% and 83.0% for BEC2, 91.7% and 83.0% for BEC3, and 95.8% and 98.3% for BEC4. Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897, respectively. CONCLUSION: This is the first study to investigate classification system of ECS in BE. This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. PMID:24379583
Coherent quantum depletion of an interacting atom condensate
Kira, M.
2015-01-01
Sufficiently strong interactions promote coherent quantum transitions in spite of thermalization and losses, which are the adversaries of delicate effects such as reversibility and correlations. In atomic Bose–Einstein condensates (BECs), strong atom–atom interactions can eject atoms from the BEC to the normal component, yielding quantum depletion instead of temperature depletion. A recent experiment has already been verified to overcome losses. Here I show that it also achieves coherent quantum-depletion dynamics in a BEC swept fast enough from weak to strong atom–atom interactions. The elementary coherent process first excites the normal component into a liquid state that evolves into a spherical shell state, where the atom occupation peaks at a finite momentum to shield 50% of the BEC atoms from annihilation. The identified coherent processes resemble ultrafast semiconductor excitations expanding the scope of BEC explorations to many-body non-equilibrium studies. PMID:25767044
NASA Astrophysics Data System (ADS)
Stein, Rüdiger; Kucera, Michal; Walter, Maren; de Vernal, Anne
2015-04-01
Due to a complex set of feedback processes collectively known as "polar amplification", the Arctic realm is expected to experience a greater-than-average response to global climate forcing. The cascades of feedback processes that connect the Arctic cryosphere, ocean and atmosphere remain incompletely constrained by observations and theory and are difficult to simulate in climate models. Our capacity to predict the future of the region and assess the impacts of Arctic change processes on global and regional environments hinges on the availability of interdisciplinary experts with strong international experience and understanding of the science/society interface. This is the basis of the International Research Training Group "Processes and impacts of climate change in the North Atlantic Ocean and the Canadian Arctic - ArcTrain", which was initiated in 2013. ArcTrain aims to educate PhD students in an interdisciplinary environment that combines paleoclimatology, physical oceanography, remote sensing and glaciology with comprehensive Earth system modelling, including sea-ice and ice-sheet components. The qualification program for the PhD students includes joint supervision, mandatory research residences at partner institutions, field courses on land and on sea (Floating University), annual meetings and training workshops and a challenging structured training in expert skills and transferrable skills. Its aim is to enhance the career prospects and employability of the graduates in a challenging international job market across academic and applied sectors. ArcTrain is a collaborative project at the University of Bremen and the Alfred Wegener Institute for Polar and Marine Research in Bremerhaven. The German part of the project is designed to continue for nine years and educate three cohorts of twelve PhD students each. The Canadian partners comprise a consortium of eight universities led by the GEOTOP cluster at the Université du Québec à Montréal and including Dalhousie University, McGill University, Memorial University of Newfoundland, University of Alberta, University of British Columbia, University of Calgary and Université du Québec à Rimouski. Further details about ArcTrain are available at: https://www.marum.de/ArcTrain.html
[Towards Professionalization : the Editorial Discourse of Québec Pharmacy magazine, 1960-2013 ].
Savard, Pierre-André; Meunier-Sirois, Alexandre; Marando, Nancy; Bussières, Jean-François
2016-12-01
The second half of the twentieth century and the beginning of the 2000s marked deep changes in the practice of pharmacy in Quebec. The editorials of Québec Pharmacie journal attest these changes on a 50-year period by relating power relationships, conflicts, problems and solutions that concerned pharmacists. This article proposes to analyze the editorial discourse of Québec Pharmacie journal between 1960 and 2013, and to grasp the evolution of the speech. To do so, we analyze the major topics addressed by the editorialists. It appears that Québec Pharmacie’s editorialists aimed the professionalization of pharmacy.
Choi, Tae-Young; Ninov, Nikolay; Stainier, Didier Y R; Shin, Donghun
2014-03-01
Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of hepatocyte ablation can be controlled. Hepatocytes were depleted by administration of metronidazole to Tg(fabp10a:CFP-NTR) animals. We traced the origin of regenerating hepatocytes using short-term lineage-tracing experiments, as well as the inducible Cre/loxP system; specifically, we utilized both a BEC tracer line Tg(Tp1:CreER(T2)) and a hepatocyte tracer line Tg(fabp10a:CreER(T2)). We also examined BEC and hepatocyte proliferation and liver marker gene expression during liver regeneration. BECs gave rise to most of the regenerating hepatocytes in larval and adult zebrafish after severe hepatocyte depletion. After hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subsequently differentiated into highly proliferative hepatocytes that restored the liver mass. This process was impaired in zebrafish wnt2bb mutants; in these animals, hepatocytes regenerated but their proliferation was greatly reduced. BECs contribute to regenerating hepatocytes after substantial hepatocyte depletion in zebrafish, thereby leading to recovery from severe liver damage. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.
Effective equations for matter-wave gap solitons in higher-order transversal states.
Mateo, A Muñoz; Delgado, V
2013-10-01
We demonstrate that an important class of nonlinear stationary solutions of the three-dimensional (3D) Gross-Pitaevskii equation (GPE) exhibiting nontrivial transversal configurations can be found and characterized in terms of an effective one-dimensional (1D) model. Using a variational approach we derive effective equations of lower dimensionality for BECs in (m,n(r)) transversal states (states featuring a central vortex of charge m as well as n(r) concentric zero-density rings at every z plane) which provides us with a good approximate solution of the original 3D problem. Since the specifics of the transversal dynamics can be absorbed in the renormalization of a couple of parameters, the functional form of the equations obtained is universal. The model proposed finds its principal application in the study of the existence and classification of 3D gap solitons supported by 1D optical lattices, where in addition to providing a good estimate for the 3D wave functions it is able to make very good predictions for the μ(N) curves characterizing the different fundamental families. We have corroborated the validity of our model by comparing its predictions with those from the exact numerical solution of the full 3D GPE.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hanai, Ryo; Littlewood, Peter B.; Ohashi, Yoji
2017-09-01
We present a stability analysis on a driven-dissipative electron-hole condensate in the BCS (Bardeen-Cooper-Schrieffer)-BEC (Bose-Einstein-condensation)-crossover region. Extending the combined BCS-Leggett theory with the generalized random phase approximation (GRPA) to the non-equilibrium case by employing the Keldysh formalism, we show that the pumping-and-decay of carriers causes a depairing effect on excitons. This phenomenon gives rise to an attractive interaction between excitons in the BEC regime, as well as a supercurrent that anomalously flows anti-parallel to ∇θ(r) (where θ(r) is the phase of the condensate) in the BCS regime, both leading to dynamical instabilities of an exciton-BEC.
NASA Astrophysics Data System (ADS)
Pi, E. I.; Siegel, E.
2010-03-01
Siegel[AMS Natl.Mtg.(2002)-Abs.973-60-124] digits logarithmic- law inversion to ONLY BEQS BEC:Quanta/Bosons=#: EMP-like SEVERE VULNERABILITY of ONLY #-networks(VS.ANALOG INvulnerability) via Barabasi NP(VS.dynamics[Not.AMS(5/2009)] critique);(so called)``quantum-computing''(QC) = simple-arithmetic (sansdivision);algorithmiccomplexities:INtractibility/UNdecidabi lity/INefficiency/NONcomputability/HARDNESS(so MIScalled) ``noise''-induced-phase-transition(NIT)ACCELERATION:Cook-Levin theorem Reducibility = RG fixed-points; #-Randomness DEFINITION via WHAT? Query(VS. Goldreich[Not.AMS(2002)] How? mea culpa)= ONLY MBCS hot-plasma v #-clumping NON-random BEC; Modular-Arithmetic Congruences = Signal x Noise PRODUCTS = clock-model; NON-Shor[Physica A,341,586(04)]BEC logarithmic-law inversion factorization: Watkins #-theory U statistical- physics); P=/=NP C-S TRIVIAL Proof: Euclid!!! [(So Miscalled) computational-complexity J-O obviation(3 millennia AGO geometry: NO:CC,``CS'';``Feet of Clay!!!'']; Query WHAT?:Definition: (so MIScalled)``complexity''=UTTER-SIMPLICITY!! v COMPLICATEDNESS MEASURE(S).
Okazaki, K; Ito, Y; Ota, Y; Kotani, Y; Shimojima, T; Kiss, T; Watanabe, S; Chen, C-T; Niitaka, S; Hanaguri, T; Takagi, H; Chainani, A; Shin, S
2014-02-28
Conventional superconductivity follows Bardeen-Cooper-Schrieffer(BCS) theory of electrons-pairing in momentum-space, while superfluidity is the Bose-Einstein condensation(BEC) of atoms paired in real-space. These properties of solid metals and ultra-cold gases, respectively, are connected by the BCS-BEC crossover. Here we investigate the band dispersions in FeTe(0.6)Se(0.4)(Tc = 14.5 K ~ 1.2 meV) in an accessible range below and above the Fermi level(EF) using ultra-high resolution laser angle-resolved photoemission spectroscopy. We uncover an electron band lying just 0.7 meV (~8 K) above EF at the Γ-point, which shows a sharp superconducting coherence peak with gap formation below Tc. The estimated superconducting gap Δ and Fermi energy [Symbol: see text]F indicate composite superconductivity in an iron-based superconductor, consisting of strong-coupling BEC in the electron band and weak-coupling BCS-like superconductivity in the hole band. The study identifies the possible route to BCS-BEC superconductivity.
Progress towards broadband Raman quantum memory in Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Saglamyurek, Erhan; Hrushevskyi, Taras; Smith, Benjamin; Leblanc, Lindsay
2017-04-01
Optical quantum memories are building blocks for quantum information technologies. Efficient and long-lived storage in combination with high-speed (broadband) operation are key features required for practical applications. While the realization has been a great challenge, Raman memory in Bose-Einstein condensates (BECs) is a promising approach, due to negligible decoherence from diffusion and collisions that leads to seconds-scale memory times, high efficiency due to large atomic density, the possibility for atom-chip integration with micro photonics, and the suitability of the far off-resonant Raman approach with storage of broadband photons (over GHz) [5]. Here we report our progress towards Raman memory in a BEC. We describe our apparatus recently built for producing BEC with 87Rb atoms, and present the observation of nearly pure BEC with 5x105 atoms at 40 nK. After showing our initial characterizations, we discuss the suitability of our system for Raman-based light storage in our BEC.
NASA Astrophysics Data System (ADS)
Liu, Chao-Fei; Juzeliūnas, Gediminas; Liu, W. M.
2017-02-01
Atomic-molecular Bose-Einstein condensates (BECs) offer brand new opportunities to revolutionize quantum gases and probe the variation of fundamental constants with unprecedented sensitivity. The recent realization of spin-orbit coupling (SOC) in BECs provides a new platform for exploring completely new phenomena unrealizable elsewhere. In this study, we find a way of creating a Rashba-Dresselhaus SOC in atomic-molecular BECs by combining the spin-dependent photoassociation and Raman coupling, which can control the formation and distribution of a different type of topological excitation—carbon-dioxide-like skyrmion. This skyrmion is formed by two half-skyrmions of molecular BECs coupling with one skyrmion of atomic BECs, where the two half-skyrmions locate at both sides of one skyrmion. Carbon-dioxide-like skyrmion can be detected by measuring the vortices structures using the time-of-flight absorption imaging technique in real experiments. Furthermore, we find that SOC can effectively change the occurrence of the Chern number in k space, which causes the creation of topological spin textures from some separated carbon-dioxide-like monomers each with topological charge -2 to a polymer chain of the skyrmions. This work helps in creating dual SOC atomic-molecular BECs and opens avenues to manipulate topological excitations.
Mallory, Kristina; Van Gorder, Robert A
2015-07-01
Stationary solutions for the cubic nonlinear Schrödinger equation modeling Bose-Einstein condensates (BECs) confined in three spatial dimensions by general forms of a potential are studied through a perturbation method and also numerically. Note that we study both repulsive and attractive BECs under similar frameworks in order to deduce the effects of the potentials in each case. After outlining the general framework, solutions for a collection of specific confining potentials of physical relevance to experiments on BECs are provided in order to demonstrate the approach. We make several observations regarding the influence of the particular potentials on the behavior of the BECs in these cases, comparing and contrasting the qualitative behavior of the attractive and repulsive BECs for potentials of various strengths and forms. Finally, we consider the nonperturbative where the potential or the amplitude of the solutions is large, obtaining various qualitative results. When the kinetic energy term is small (relative to the nonlinearity and the confining potential), we recover the expected Thomas-Fermi approximation for the stationary solutions. Naturally, this also occurs in the large mass limit. Through all of these results, we are able to understand the qualitative behavior of spherical three-dimensional BECs in weak, intermediate, or strong confining potentials.
NASA Astrophysics Data System (ADS)
Huffmann, Master; Siegel, Edward Carl-Ludwig
2013-03-01
Newcomb-Benford(NeWBe)-Siegel log-law BEC Digit-Physics Network/Graph-Physics Barabasi et.al. evolving-``complex''-networks/graphs BEC JAMMING DOA attacks: Amazon(weekends: Microsoft I.E.-7/8(vs. Firefox): Memorial-day, Labor-day,...), MANY U.S.-Banks:WF,BoA,UB,UBS,...instantiations AGAIN militate for MANDATORY CONVERSION to PARALLEL ANALOG FAULT-TOLERANT but slow(er) SECURITY-ASSURANCE networks/graphs in parallel with faster ``sexy'' DIGITAL-Networks/graphs:``Cloud'', telecomm: n-G,..., because of common ACHILLES-HEEL VULNERABILITY: DIGITS!!! ``In fast-hare versus slow-tortoise race, Slow-But-Steady ALWAYS WINS!!!'' (Zeno). {Euler [#s(1732)] ∑- ∏()-Riemann[Monats. Akad. Berlin (1859)] ∑- ∏()- Kummer-Bernoulli (#s)}-Newcomb [Am.J.Math.4(1),39 (81) discovery of the QUANTUM!!!]-{Planck (01)]}-{Einstein (05)]-Poincar e [Calcul Probabilités,313(12)]-Weyl[Goett. Nach.(14); Math.Ann.77,313(16)]-(Bose (24)-Einstein(25)]-VS. -Fermi (27)-Dirac(27))-Menger [Dimensiontheorie(29)]-Benford [J.Am. Phil.Soc.78,115(38)]-Kac[Maths Stats.-Reason. (55)]- Raimi [Sci.Am.221,109(69)]-Jech-Hill [Proc.AMS,123,3,887(95)] log-function
Characterization of household food insecurity in Québec: food and feelings.
Hamelin, Anne-Marie; Beaudry, Micheline; Habicht, Jean-Pierre
2002-01-01
This study was undertaken to understand food insecurity from the perspective of households who experienced it. The results of group interviews and personal interviews with 98 low-income households from urban and rural areas in and around Québec City, Canada, elicited the meaning of "enough food" for the households and the range of manifestations of food insecurity. Two classes of manifestations characterized the experience of food insecurity: (1) its core characteristics: a lack of food encompassing the shortage of food, the unsuitability of both food and diet and a preoccupation with continuity in access to enough food; and a lack of control of households over their food situation; and (2) a related set of potential reactions: socio-familial perturbations, hunger and physical impairment, and psychological suffering. The results substantiate the existence of food insecurity among Québecers and confirm that the nature of this experience is consistent with many of the core components identified in upstate New York. This study underlines the monotony of the diet, describes the feeling of alienation, differentiates between a lack of food and the reactions that it engenders, and emphasizes the dynamic nature of the experience.
Entanglement, nonlocality and multi-particle quantum correlations
NASA Astrophysics Data System (ADS)
Reid, Margaret D.
2018-04-01
This paper contributes to the proceedings of the Latin-American School of Physics (ELAF-2017) on Quantum Correlations, and is a brief review of quantum entanglement and nonlocality. In such a brief review, only some topics can be covered. The emphasis is on those topics relevant that may be relevant to detecting multi-particle quantum correlations arising in atomic and Bose-Einstein condensate (BEC) experiments. The paper is divided into five sections. In the first section, the historical papers of Einstein-Podolsky-Rosen (EPR), Bell, Schrodinger and Greenberger-Zeilinger-Horne (GHZ) are described in a tutorial fashion. This is followed by an introduction to entanglement and density operators. A discussion of the classes of nonlocality is given in the third section, including the modern interpretation of the correlations of the EPR paradox experiments, known as EPR steering correlations. The fourth section covers the detection and generation of so-called continuous variable entanglement and EPR steering. Various known criteria are derived with the details of the proofs given for tutorial purposes. The final section focuses on the criteria and methods that have been useful to detect quantum correlation in BEC or atomic systems. Recent results relating spin squeezing with quantum correlations, including entanglement and EPR steering, are summarised.
Yonogi, Shinya; Matsuda, Shigeaki; Kawai, Takao; Yoda, Tomoko; Harada, Tetsuya; Kumeda, Yuko; Gotoh, Kazuyoshi; Hiyoshi, Hirotaka; Nakamura, Shota; Kodama, Toshio
2014-01-01
Clostridium perfringens is a causative agent of food-borne gastroenteritis for which C. perfringens enterotoxin (CPE) has been considered an essential factor. Recently, we experienced two outbreaks of food-borne gastroenteritis in which non-CPE producers of C. perfringens were strongly suspected to be the cause. Here, we report a novel enterotoxin produced by C. perfringens isolates, BEC (binary enterotoxin of C. perfringens). Culture supernatants of the C. perfringens strains showed fluid-accumulating activity in rabbit ileal loop and suckling mouse assays. Purification of the enterotoxic substance in the supernatants and high-throughput sequencing of genomic DNA of the strains revealed BEC, composed of BECa and BECb. BECa and BECb displayed limited amino acid sequence similarity to other binary toxin family members, such as the C. perfringens iota toxin. The becAB genes were located on 54.5-kb pCP13-like plasmids. Recombinant BECb (rBECb) alone had fluid-accumulating activity in the suckling mouse assay. Although rBECa alone did not show enterotoxic activity, rBECa enhanced the enterotoxicity of rBECb when simultaneously administered in suckling mice. The entertoxicity of the mutant in which the becB gene was disrupted was dramatically decreased compared to that of the parental strain. rBECa showed an ADP-ribosylating activity on purified actin. Although we have not directly evaluated whether BECb delivers BECa into cells, rounding of Vero cells occurred only when cells were treated with both rBECa and rBECb. These results suggest that BEC is a novel enterotoxin of C. perfringens distinct from CPE, and that BEC-producing C. perfringens strains can be causative agents of acute gastroenteritis in humans. Additionally, the presence of becAB on nearly identical plasmids in distinct lineages of C. perfringens isolates suggests the involvement of horizontal gene transfer in the acquisition of the toxin genes. PMID:24664508
Theory of a Nearly Two-Dimensional Dipolar Bose Gas
2016-05-11
temperatures, and when roton excitations are present. Further, BECs in nearly 2D geometries take the form of quasi -condensates, or BECs with finite spatial...extent. Quasi -condensates behave like BECs on shorter length scales, but not on longer length scales. The project incorporates the presence of a quasi ... Quasi -Condensate 23 J. Superfluidity 25 III. Results 26 A. Three Dimensions with Contact Interactions 26 B. Two Dimensions with Contact Interactions
NASA Astrophysics Data System (ADS)
St-Onge, Guillaume; Veiga-Pires, Cristina; Solignac, Sandrine
2011-05-01
IODP logoECORD logo The European Consortium for Ocean Drilling Program (ECORD), the Canadian Consortium for Ocean Drilling (CCOD), the Network of the Universités du Québec (UQ), the Université du Québec à Montréal (UQAM) and GEOTOP sponsored, in 2010, a summer school entitled 'Ocean and climate changes in polar and sub-polar environments'. This summer school took place from 27 June to 12 July in Rimouski, Québec city and Montréal (Quebec, Canada) and was attended by nineteen students and postdoctoral fellows from seven countries: Canada, France, Germany, UK, Serbia, Portugal and the USA. Lectures, hands-on laboratory exercises and laboratory visits were conducted at the Institut des Sciences de la Mer de Rimouski (ISMER), Institut National de la Recherche Scientifique - Centre Eau Terre Environnement (INRS-ETE) and UQAM, in addition to two field trips and a short geological and geophysical cruise on board the R/V Coriolis II in the St Lawrence Estuary and Saguenay Fjord. During the summer school, more than twenty researchers gave lectures on the use of several paleoceanographic and geophysical techniques to reconstruct ocean and climate changes in polar and sub-polar environments. Some of these lectures are presented as short review papers in this volume. They are intended to portray a brief, but state-of-the-art overview of an array of techniques applied to Arctic and sub-Arctic environments, as well as the geological background information needed by the summer school participants to put the scientific expedition and fieldwork into context. The volume begins with a view on the great challenges and key issues to be addressed in the Arctic Ocean (Stein) in the forthcoming years and is followed by a review (O'Regan) on Late Cenozoic paleoceanography of the Central Arctic. The two subsequent papers (St-Onge et al and de Vernal et al) deal with the oceanographic, paleoceanographic and geological context of the Saguenay Fjord, and St Lawrence Estuary and Gulf. The subsequent set of papers review the use of planktonic foraminifers (Eynaud), diatoms (Crosta) and dinocysts (de Vernal and Rochon) in polar or sub-polar environments. These articles are followed by a paper on transfer functions (Guiot) summarizing the different approaches used to reconstruct past environmental conditions from micropaleontological proxy data. Two papers on geochemical and isotopic proxies are then presented and related to either foraminifera isotopic records (Hillaire-Marcel) in high northern latitudes or changes in ocean circulation and weathering inputs derived from radiogenic isotopes (Frank). The volume concludes with a paper on the application of visible/near infrared derivative spectroscopy to Arctic sediments (Ortiz). All the papers published in this volume benefited from the reviews of at least two reviewers, whom we thank for their valuable time and comments. We also thank the crew of the Coriolis II, and the many scientists, participants and volunteers who contributed to the summer school and made it a great success. In addition to GEOTOP and UQAM, the following institutions contributed to the organization of the summer school: ISMER, INRS-ETE, the Geological Survey of Canada, and REFORMAR. Finally, we thank Hélène Gaonac'h (UQAM) for coordinating the summer school and Anne de Vernal (UQAM) for her leadership throughout the summer school. Editors Guillaume St-Onge Canada Research Chair in Marine Geology, Institut des sciences de la mer de Rimouski (ISMER) & GEOTOP Research Center, 310 allée des Ursulines, Rimouski, Québec, Canada, G5L 3A1 Cristina Veiga-Pires FCMA - CIMA, Universidade do Algarve, Campus de Gambelas, 8000-117 Faro, Portugal Sandrine Solignac GEOTOP, Université du Québec à Montréal, PO Box 8888, succursale 'centre ville' Montréal, QC, H3C 3P8 Canada Scientists who contributed to the summer school: Hans Asnong (UQAM/GEOTOP, Canada) Gilles Bellefleur (Geological Survey of Canada-Ottawa, Canada) Anne de Vernal (UQAM/GEOTOP, Canada) Mathieu Duchesne (Geological Survey of Canada-Québec, Canada) Frédérique Eynaud (EPOC/Universite Bordeaux I, France) Pierre Francus (INRS-ETE/GEOTOP, Canada) Martin Frank (IFM-GEOMAR, Germany) Yves Gélinas (Concordia/GEOTOP, Canada) Joël Guiot (CEREGE, France) Claude Hillaire-Marcel (UQAM/GEOTOP, Canada) Patrick Lajeunesse (University Laval, Canada) Jean-François Lemieux (Courant Institute of Mathematical Sciences, New York University, USA) Guillaume Massé (LOCEAN/Institut Pierre-Simon Laplace, France) Matt O'Regan (Cardiff University, UK) Joseph Ortiz (Kent State University, USA) Frank Rack (University Nebraska-Lincoln, USA/ANDRILL Science Management Office) Taoufik Radi (UQAM/GEOTOP, Canada) André Rochon (ISMER-UQAR/GEOTOP, Canada) Ruediger Stein (Alfred Wegener Institute, Germany) Guillaume St-Onge (ISMER-UQAR/GEOTOP, Canada) Bjorn Sundby (ISMER-UQAR, Canada) GEOTOP logoUQAM UQAR logoINRS logo Universite de Quebec logoGeological Survey of Canada logo
GPELab, a Matlab toolbox to solve Gross-Pitaevskii equations II: Dynamics and stochastic simulations
NASA Astrophysics Data System (ADS)
Antoine, Xavier; Duboscq, Romain
2015-08-01
GPELab is a free Matlab toolbox for modeling and numerically solving large classes of systems of Gross-Pitaevskii equations that arise in the physics of Bose-Einstein condensates. The aim of this second paper, which follows (Antoine and Duboscq, 2014), is to first present the various pseudospectral schemes available in GPELab for computing the deterministic and stochastic nonlinear dynamics of Gross-Pitaevskii equations (Antoine, et al., 2013). Next, the corresponding GPELab functions are explained in detail. Finally, some numerical examples are provided to show how the code works for the complex dynamics of BEC problems.
Jain, Vaibhav; Raina, Shikha; Gheware, Atish Prabhakar; Singh, Rita; Rehman, Rakhshinda; Negi, Vinny; Murray Stewart, Tracy; Mabalirajan, Ulaganathan; Mishra, Adarsh Kumar; Casero, Robert A; Agrawal, Anurag; Ghosh, Balaram
2018-05-05
Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored. Though high levels of polyamines, mainly spermine, have been found in asthma and co-morbidity, their role in airway epithelial injury and the cause of their altered levels in asthma has not been explored. We measured key polyamine metabolic enzymes in lung samples from normal and asthmatic subjects and in mice with OVA-induced allergic airway inflammation (AAI). Polyamine metabolism was modulated using pharmacologic/genetic modulators. Epithelial stress and apoptosis were measured by TSLP levels and TUNEL assay, respectively. We found loss of the polyamine catabolic enzymes spermidine/spermine-N (1)-acetyltransferase-1 (SAT1) and spermine oxidase (SMOX) predominantly in bronchial epithelial cells (BECs) of human asthmatic lung samples and mice with AAI. In naïve mice, SAT1 or SMOX knockdown led to airway hyper-responsiveness, remodeling and BEC apoptosis. Conversely, in mice with AAI, overexpression of either SAT1 or SMOX alleviated asthmatic features and reduced TSLP levels and BEC apoptosis. Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them. Spermine accumulation in lungs correlated with BEC apoptosis, and spermine treatment caused apoptosis of human BEAS-2B cells in vitro. Spermine induces BEC injury. Induction of polyamine catabolism may represent a novel therapeutic approach for asthma via reversing BEC stress. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Pichavant, Muriel; Charbonnier, Anne-Sophie; Taront, Solenne; Brichet, Anne; Wallaert, Benoît; Pestel, Joel; Tonnel, André-Bernard; Gosset, Philippe
2005-04-01
Airway dendritic cells (DCs) are crucial for allergen-induced sensitization and inflammation in allergic asthma. After allergen challenge, an increased number of DCs is observed in airway epithelium from patients with allergy. Because Der p 1, a cysteine protease allergen from Dermatophagoides pteronyssinus , induces chemokine production by bronchial epithelial cells (BECs), the purpose of this investigation was to evaluate the capacity of BEC exposed to Der p 1 to recruit DCs. Chemotactic activity of BEAS-2B, a bronchial epithelial cell line, and BECs from nonatopic controls and patients with allergic asthma was evaluated on the migration of precursors, immature and mature monocyte-derived DCs (MDDCs), and CD34 + -derived Langerhans cells (LCs). C-C chemokine ligand (CCL)-2, CCL5, and C-X-C chemokine ligand 10 production by BEAS-2B and BEC was increased after Der p 1 exposure, whereas the proenzyme proDer p 1 devoid of enzymatic activity had no effect. Der p 1 stimulation of BEAS-2B and BEC from both groups increased significantly the recruitment of MDDC precursors, depending on CCL2, CCL5, and C-X-C chemokine ligand 10 production. In a reconstituted polarized epithelium, apical application of Der p 1 enhanced MDDC precursor migration into the epithelial layer. Moreover, Der p 1 stimulation of BEC from patients with asthma but not from controls increased the migration of LC precursors, mainly dependent on CCL20 secretion. No migration of immature and mature DCs was observed. These data confirmed that BECs participate in the homeostasis of the DC network present within the bronchial epithelium through the secretion of chemokines. In allergic asthma, upregulation of CCL20 production induced LC recruitment, the role of which remains to be determined.
Anti-inflammatory effects of antibacterials on human bronchial epithelial cells
2009-01-01
Background Human Bronchial epithelial cells (hu-BEC) have been claimed to play a significant role in the pathogenesis of chronic inflammatory airway diseases like COPD. In this context IL-8 and GM-CSF have been shown to be key cytokines. Some antibiotics which are routinely used to treat lower respiratory tract infections have been shown to exert additional immunomodulatory or anti-inflammatory effects. We investigated whether these effects can also be detected in hu-BEC. Methods Hu-BEC obtained from patients undergoing lung resections were transferred to air-liquid-interface (ALI) culture. These cultures were incubated with cefuroxime (CXM, 10-62.5 mg/l), azithromycin (AZM, 0.1-1.5 mg/l), levofloxacin (LVX, 1-8 mg/l) and moxifloxacin (MXF, 1-16 mg/l). The spontaneous and TNF-α (10 ng/ml) induced expression and release of IL-8 and GM-CSF were measured using PCR and ELISA in the absence or presence of these antibiotics. Results The spontaneous IL-8 and GM-CSF release was significantly reduced with MXF (8 mg/l) by 37 ± 20% and 45 ± 31%, respectively (both p < 0.01). IL-8 release in TNF-α stimulated hu-BEC decreased by 16 ± 8% (p < 0.05) with AZM (1.5 mg/l). With MXF a concentration dependent decrease of IL-8 release was noted up to 39 ± 7% (p < 0.05). GM-CSF release from TNF-α stimulated hu-BEC was maximally decreased by 35 ± 24% (p < 0.01) with MXF (4 mg/l). Conclusion Using ALI cultures of hu-BEC we observed differential effects of antibiotics on spontaneous and TNF-α induced cytokine release. Our data suggest that MXF and AZM, beyond bactericidal effects, may attenuate the inflammatory process mediated by hu-BEC. PMID:19788749
Interference, focusing and excitation of ultracold atoms
NASA Astrophysics Data System (ADS)
Kandes, M. C.; Fahy, B. M.; Williams, S. R.; Tally, C. H., IV; Bromley, M. W. J.
2011-05-01
One of the pressing technological challenges in atomic physics is to go orders-of-magnitude beyond the limits of photon-based optics by harnessing the wave-nature of dilute clouds of ultracold atoms. We have developed parallelised algorithms to perform numerical calculations of the Gross-Pitaevskii equation in up to three dimensions and with up to three components to simulate Bose-Einstein condensates. A wide-ranging array of the physics associated with atom optics-based systems will be presented including BEC-based Sagnac interferometry in circular waveguides, the focusing of BECs using Laguerre-Gauss beams, and the interactions between BECs and Ince-Gaussian laser beams and their potential applications. One of the pressing technological challenges in atomic physics is to go orders-of-magnitude beyond the limits of photon-based optics by harnessing the wave-nature of dilute clouds of ultracold atoms. We have developed parallelised algorithms to perform numerical calculations of the Gross-Pitaevskii equation in up to three dimensions and with up to three components to simulate Bose-Einstein condensates. A wide-ranging array of the physics associated with atom optics-based systems will be presented including BEC-based Sagnac interferometry in circular waveguides, the focusing of BECs using Laguerre-Gauss beams, and the interactions between BECs and Ince-Gaussian laser beams and their potential applications. Performed on computational resources via NSF grants PHY-0970127, CHE-0947087 and DMS-0923278.
An IMU-Aided Body-Shadowing Error Compensation Method for Indoor Bluetooth Positioning
Deng, Zhongliang
2018-01-01
Research on indoor positioning technologies has recently become a hotspot because of the huge social and economic potential of indoor location-based services (ILBS). Wireless positioning signals have a considerable attenuation in received signal strength (RSS) when transmitting through human bodies, which would cause significant ranging and positioning errors in RSS-based systems. This paper mainly focuses on the body-shadowing impairment of RSS-based ranging and positioning, and derives a mathematical expression of the relation between the body-shadowing effect and the positioning error. In addition, an inertial measurement unit-aided (IMU-aided) body-shadowing detection strategy is designed, and an error compensation model is established to mitigate the effect of body-shadowing. A Bluetooth positioning algorithm with body-shadowing error compensation (BP-BEC) is then proposed to improve both the positioning accuracy and the robustness in indoor body-shadowing environments. Experiments are conducted in two indoor test beds, and the performance of both the BP-BEC algorithm and the algorithms without body-shadowing error compensation (named no-BEC) is evaluated. The results show that the BP-BEC outperforms the no-BEC by about 60.1% and 73.6% in terms of positioning accuracy and robustness, respectively. Moreover, the execution time of the BP-BEC algorithm is also evaluated, and results show that the convergence speed of the proposed algorithm has an insignificant effect on real-time localization. PMID:29361718
An IMU-Aided Body-Shadowing Error Compensation Method for Indoor Bluetooth Positioning.
Deng, Zhongliang; Fu, Xiao; Wang, Hanhua
2018-01-20
Research on indoor positioning technologies has recently become a hotspot because of the huge social and economic potential of indoor location-based services (ILBS). Wireless positioning signals have a considerable attenuation in received signal strength (RSS) when transmitting through human bodies, which would cause significant ranging and positioning errors in RSS-based systems. This paper mainly focuses on the body-shadowing impairment of RSS-based ranging and positioning, and derives a mathematical expression of the relation between the body-shadowing effect and the positioning error. In addition, an inertial measurement unit-aided (IMU-aided) body-shadowing detection strategy is designed, and an error compensation model is established to mitigate the effect of body-shadowing. A Bluetooth positioning algorithm with body-shadowing error compensation (BP-BEC) is then proposed to improve both the positioning accuracy and the robustness in indoor body-shadowing environments. Experiments are conducted in two indoor test beds, and the performance of both the BP-BEC algorithm and the algorithms without body-shadowing error compensation (named no-BEC) is evaluated. The results show that the BP-BEC outperforms the no-BEC by about 60.1% and 73.6% in terms of positioning accuracy and robustness, respectively. Moreover, the execution time of the BP-BEC algorithm is also evaluated, and results show that the convergence speed of the proposed algorithm has an insignificant effect on real-time localization.
2007-09-01
immunofluorescence (IFM) and light microscopy. Samples were fixed in forma- lin, stained with immunofluorescent dyes (as described below) or spore stain ( malachite ...BEC. Adherence was assessed by microscopic observation of the infected cells stained with malachite green and counterstaining of the BEC. For enzymatic...this significant difference, BEC infected with spores were stained with malachite green and counter- stained with Wright-Giemsa (Fig. 1B and C). This
NASA Astrophysics Data System (ADS)
Pisani, L.; Perali, A.; Pieri, P.; Strinati, G. Calvanese
2018-01-01
The problem of the theoretical description of the critical temperature Tc of a Fermi superfluid dates back to the work by Gorkov and Melik-Barkhudarov (GMB), who addressed it for a weakly coupled (dilute) superfluid in what would today be referred to as the (extreme) BCS (weak-coupling) limit of the BCS-BEC crossover. The point made in this context by GMB was that particle-particle (pairing) excitations, which are responsible for superfluidity to occur below Tc, and particle-hole excitations, which give rise to screening also in a normal system, get effectively disentangled from each other in the BCS limit, thus yielding a reduction by a factor of 2.2 of the value of Tc obtained when neglecting screening effects. Subsequent work on this topic, that was aimed at extending the original GMB argument away from the BCS limit with diagrammatic methods, has tout court kept this disentangling between pairing and screening throughout the BCS-BEC crossover, without realizing that the conditions for it to be valid are soon violated away from the BCS limit. Here, we reconsider this problem from a more general perspective and argue that pairing and screening are intrinsically entangled with each other along the whole BCS-BEC crossover but for the BCS limit considered by GMB, with the particle-hole excitations soon transmuting into particle-particle excitations away from this limit. We substantiate our argument by performing a detailed numerical calculation of the GMB diagrammatic contribution suitably extended to the whole BCS-BEC crossover, where the full wave-vector and frequency dependence occurring in the repeated in-medium two-particle scattering is duly taken into account. Our numerical calculations are tested against analytic results available in both the BCS and BEC limits, and the contribution of the GMB diagrammatic term to the scattering length of composite bosons in the BEC limit is highlighted. We calculate Tc throughout the BCS-BEC crossover and find that it agrees quite well with quantum Monte Carlo calculations and experimental data available in the unitarity regime.
NASA Astrophysics Data System (ADS)
Reed, Don
With the announcement of the recent successful production of a Bose-Einstein condensate (BEC) of photons, a circle has been completed which started in 1925 with the vision of Albert Einstein and Satyendra Nath Bose - a sustained macroscopic condensed state of matter where all atoms are in the same lowest quantum state. The creation of an all-optical BEC, involving a surprisingly straightforward "tabletop" method which bypasses the normally requisite laser/evaporative cooling equipment and ultra-high vacuum chambers necessary for production of the standard delicate atomic BEC, elevates this phenomenon to a new level well beyond its current perception as mere laboratory curiosity. Accordingly, this development certainly heralds eventual incorporation of atomic and photon BECs as standard operating components of energy-efficient mechanical, optical and electrical systems, implying novel ingenious engineering protocols amenable to all the tools of non-linear and quantum optics. Pointing towards such a promising technological future are the suggestion that a photon BEC could serve as a new high-energy ultra-violet (UV) laser photon source, as well as the recent unprecedented implementation of a closed-loop atom circuit (toroidal atomic BEC) demonstrating precise control of superfluid current flow, forecasting the coveted development of an atomic SQUID. Perhaps more significantly, the new highly robust and manageable optical BEC will allow heretofore unfathomable precise probing of the atomic and nano-levels of nature, affording novel high-quality testing procedures of the major foundations of quantum mechanics itself. Such a primary advancement, providing a clearer glimpse into the microscopic realms, may present us as never before with an unprecedented view of the quantum engine that underpins physical reality itself and help place the contextual nature of entanglement and quantum superposition on a firmer foundation. Thus, further progress in achieving mastery over the precise flexible manipulation of BEC states could demonstrate that quantum contextuality might be an unsuspected over-arching archetypal principle in nature, leading to new insight in regards to the interpretation of quantum mechanics as applied to all levels of nature. Moreover, it will be shown that this concealed and hence heretofore unsuspected contextual aspect of natural laws, as exemplified by the dynamics underlying BEC structure, could be brought to bear to account for physical anomalies inexplicable using current paradigms, such as the claimed energy yields from low-energy nuclear reactions (as represented by the so-called process of "cold fusion"), making this phenomenon more tractable and rendered less controversial.
Number-squeezed and fragmented states of strongly interacting bosons in a double well
NASA Astrophysics Data System (ADS)
Corbo, Joel C.; DuBois, Jonathan L.; Whaley, K. Birgitta
2017-11-01
We present a systematic study of the phenomena of number squeezing and fragmentation for a repulsive Bose-Einstein condensate (BEC) in a three-dimensional double-well potential over a range of interaction strengths and barrier heights, including geometries that exhibit appreciable overlap in the one-body wave functions localized in the left and right wells. We compute the properties of the condensate with numerically exact, full-dimensional path-integral ground-state (PIGS) quantum Monte Carlo simulations and compare with results obtained from using two- and eight-mode truncated basis models. The truncated basis models are found to agree with the numerically exact PIGS simulations for weak interactions, but fail to correctly predict the amount of number squeezing and fragmentation exhibited by the PIGS simulations for strong interactions. We find that both number squeezing and fragmentation of the BEC show nonmonotonic behavior at large values of interaction strength a . The number squeezing shows a universal scaling with the product of number of particles and interaction strength (N a ), but no such universal behavior is found for fragmentation. Detailed analysis shows that the introduction of repulsive interactions not only suppresses number fluctuations to enhance number squeezing, but can also enhance delocalization across wells and tunneling between wells, each of which may suppress number squeezing. This results in a dynamical competition whose resolution shows a complex dependence on all three physical parameters defining the system: interaction strength, number of particles, and barrier height.
Subsonic and Supersonic Effects in Bose-Einstein Condensate
NASA Technical Reports Server (NTRS)
Zak, Michail
2003-01-01
A paper presents a theoretical investigation of subsonic and supersonic effects in a Bose-Einstein condensate (BEC). The BEC is represented by a time-dependent, nonlinear Schroedinger equation that includes terms for an external confining potential term and a weak interatomic repulsive potential proportional to the number density of atoms. From this model are derived Madelung equations, which relate the quantum phase with the number density, and which are used to represent excitations propagating through the BEC. These equations are shown to be analogous to the classical equations of flow of an inviscid, compressible fluid characterized by a speed of sound (g/Po)1/2, where g is the coefficient of the repulsive potential and Po is the unperturbed mass density of the BEC. The equations are used to study the effects of a region of perturbation moving through the BEC. The excitations created by a perturbation moving at subsonic speed are found to be described by a Laplace equation and to propagate at infinite speed. For a supersonically moving perturbation, the excitations are found to be described by a wave equation and to propagate at finite speed inside a Mach cone.
Ultrathin Graphene-Protein Supercapacitors for Miniaturized Bioelectronics.
Mosa, Islam M; Pattammattel, Ajith; Kadimisetty, Karteek; Pande, Paritosh; El-Kady, Maher F; Bishop, Gregory W; Novak, Marc; Kaner, Richard B; Basu, Ashis K; Kumar, Challa V; Rusling, James F
2017-09-06
Nearly all implantable bioelectronics are powered by bulky batteries which limit device miniaturization and lifespan. Moreover, batteries contain toxic materials and electrolytes that can be dangerous if leakage occurs. Herein, an approach to fabricate implantable protein-based bioelectrochemical capacitors (bECs) employing new nanocomposite heterostructures in which 2D reduced graphene oxide sheets are interlayered with chemically modified mammalian proteins, while utilizing biological fluids as electrolytes is described. This protein-modified reduced graphene oxide nanocomposite material shows no toxicity to mouse embryo fibroblasts and COS-7 cell cultures at a high concentration of 1600 μg mL -1 which is 160 times higher than those used in bECs, unlike the unmodified graphene oxide which caused toxic cell damage even at low doses of 10 μg mL -1 . The bEC devices are 1 μm thick, fully flexible, and have high energy density comparable to that of lithium thin film batteries. COS-7 cell culture is not affected by long-term exposure to encapsulated bECs over 4 d of continuous charge/discharge cycles. These bECs are unique, protein-based devices, use serum as electrolyte, and have the potential to power a new generation of long-life, miniaturized implantable devices.
NASA Astrophysics Data System (ADS)
Boshier, Malcolm; Ryu, Changhyun; Blackburn, Paul; Blinova, Alina; Henderson, Kevin
2014-05-01
The painted potential is a time-averaged optical dipole potential which is able to create arbitrary and dynamic two dimensional potentials for Bose Einstein condensates (BECs). This poster reports three recent experiments using this technique. First, we have realized the dc atom SQUID geometry of a BEC in a toroidal trap with two Josephson junctions. We observe Josephson effects, measure the critical current of the junctions, and find dynamic behavior that is in good agreement with the simple Josephson equations for a tunnel junction with the ideal sinusoidal current-phase relation expected for the parameters of the experiment. Second, we have used free expansion of a rotating toroidal BEC to create matter wave Bessel beams, which are of interest because perfect Bessel beams (plane waves with amplitude profiles described by Bessel functions) propagate without diffraction. Third, we have realized the basic circuit elements necessary to create complex matter wave circuits. We launch BECs at arbitrary velocity along straight waveguides, propagate them around curved waveguides and stadium-shaped waveguide traps, and split them coherently at y-junctions that can also act as switches. Supported by LANL/LDRD.
Composite cryogels for lysozyme purification.
Baydemir, Gözde; Türkoğlu, Emir Alper; Andaç, Müge; Perçin, Işık; Denizli, Adil
2015-01-01
Beads-embedded novel composite cryogel was synthesized to purify lysozyme (Lyz) from chicken egg white. The poly(hydroxyethyl methacrylate-N-methacryloyl-L-phenylalanine) (PHEMAPA) beads of smaller than 5 µm size were synthesized by suspension polymerization and then embedded into a poly(hydroxyethyl methacrylate) (PHEMA)-based cryogel column. The PHEMAPA bead-embedded cryogel (BEC) column was characterized by swelling tests, scanning electron microscopy (SEM), surface area measurements by the Brunauer-Emmett-Teller (BET) method, elemental analysis, and flow dynamics. The specific surface area of the PHEMAPA BEC was found as 41.2 m(2) /g using BET measurements. Lyz-binding experiments were performed using aqueous solutions in different conditions such as initial Lyz concentration, pH, flow rate, temperature, and NaCl concentration of an aqueous medium. The PHEMAPA BEC column could be used after 10 adsorption-desorption studies without any significant loss in adsorption capacity of Lyz. The PHEMAPA BEC column was used to purify Lyz from chicken egg white, and gel electrophoresis was used to estimate the purity of Lyz. The chromatographic application of the PHEMAPA BEC column was also performed using fast protein liquid chromatography. © 2014 International Union of Biochemistry and Molecular Biology, Inc.
NASA Astrophysics Data System (ADS)
Parish, Meera M.
2015-09-01
This chapter presents the crossover from the Bardeen-Cooper-Schrieffer (BCS) state of weakly correlated pairs of fermions to the Bose-Einstein condensation (BEC) of diatomic molecules in the atomic Fermi gas. Our aim is to provide a pedagogical review of the BCS-BEC crossover, with an emphasis on the basic concepts, particularly those that are not generally known or are difficult to find in the literature. We shall not attempt to give an exhaustive survey of current research in the limited space here; where possible, we will direct the reader to more extensive reviews.
The Weak-Coupling of Bose-Einstein Condensates
NASA Astrophysics Data System (ADS)
Zhou, Xiao-Ji; Ma, Zao-Yuan; Chen, Xu-Zong; Wang, Yi-Qiu
2003-04-01
The coherent characteristics of four trapped Bose-Einstein condensates (BEC) conjunct one by one in a ring shape which is divided by two far off-resonant lasers, are studied. Four coupled Gross-Pitaevskii equations are used to describe the dynamics of the system. Two kinds of self-trapping effects are discussed in the coupled BECs, and the phase diagrams for different initial conditions and different coupling strengths are discussed. This study can be used to determine interaction parameters between atoms in BEC. The project supported by National Natural Science Foundation of China under Grant No. 60271003
Riel, Jessica; Messing, Karen
2011-01-01
Québec teachers have been identified as having a high level of stress and having difficulties with work-family balancing (WFB). An analysis of their work activity was done to identify task elements that could be changed. Work of 15 teachers was observed and 20 other teachers were interviewed. Ergonomic analysis, a mixed method that combines qualitative analysis with some quantitative data: 87 hours' observation; 15 interviews. Environmental parameters were recorded in 8 classrooms and in two faculty workrooms. Working postures were recorded. Teachers were subject to numerous demands in an often inadequate environment. A new management practice required teachers to spend 300 min/week outside class but in school, where their work could be monitored. The timed and scheduled tasks could not be done in the rooms provided due to overcrowding, inadequate physical environment, and lack of access to computers and telephones. Time at home decreased but work done at home did not. The physical environment of teaching impacts teaching activity. Work organization that treats a complex, results-oriented task as if it could be well represented by the number of supervised minutes spent on it can be problematic. WFB should be considered when work is re-organized.
A nucleon-pair and boson coexistent description of nuclei
NASA Astrophysics Data System (ADS)
Dai, Lianrong; Pan, Feng; Draayer, J. P.
2017-07-01
We study a mixture of s-bosons and like-nucleon pairs with the standard pairing interaction outside an inert core. Competition between the nucleon-pairs and s-bosons is investigated in this scenario. The robustness of the BCS-BEC coexistence and crossover phenomena are examined through an analysis of pf-shell nuclei with realistic single-particle energies, in which two configurations with Pauli blocking of nucleon-pair orbits due to the formation of the s-bosons is taken into account. When the nucleon-pair orbits are considered to be independent of the s-bosons, the BCS-BEC crossover becomes smooth, with the number of the s-bosons noticeably more than that of the nucleon-pairs near the half-shell point, a feature that is demonstrated in the pf-shell for several values of the standard pairing interaction strength. As a further test of the robustness of the BCS-BEC coexistence and crossover phenomena in nuclei, results are given for values of even-even 102-130Sn with 100Sn taken as a core and valence neutron pairs confined within the 1d 5/2, 0g 7/2, 1d 3/2, 2s 1/2, 1h 11/2 orbits in the nucleon-pair orbit and the s-boson independent approximation. The results indicate that the B(E2) values are reproduced well. Supported by National Natural Science Foundation of China (11375080, 11675071), the U.S. National Science Foundation (OCI-0904874 and ACI-1516338), U. S. Department of Energy (DE-SC0005248), the Southeastern Universities Research Association, the China-U. S. Theory Institute for Physics with Exotic Nuclei (CUSTIPEN) (DE-SC0009971), and the LSU-LNNU joint research program (9961) is acknowledged
NASA Astrophysics Data System (ADS)
Rinott, Shahar; Ribak, Amit; Chashka, Khanan; Randeria, Mohit; Kanigel, Amit
The crossover from Bardeen-Cooper-Schrieffer (BCS) superconductivity to Bose-Einstein condensation (BEC) was never realized in quantum materials. It is difficult to realize because, unlike in ultra cold atoms, one cannot tune the pairing interaction. We realize the BCS-BEC crossover in a nearly compensated semimetal Fe1+ySexTe1-x by tuning the Fermi energy ɛF via chemical doping, which permits us to systematically change Δ /ɛF from 0 . 16 to 0 . 50 , where Δ is the superconducting (SC) gap. We use angle-resolved photoemission spectroscopy to measure the Fermi energy, the SC gap and characteristic changes in the SC state electronic dispersion as the system evolves from a BCS to a BEC regime. Our results raise important questions about the crossover in multi-band superconductors which go beyond those addressed in the context of cold atoms.
NASA Astrophysics Data System (ADS)
Lyons, M.; Siegel, Edward Carl-Ludwig
2011-03-01
Weiss-Page-Holthaus[Physica A,341,586(04); http://arxiv.org/abs/cond-mat/0403295] number-FACTORIZATION VIA BEQS BEC VS.(?) Shor-algorithm, strongly-supporting Watkins' [www.secamlocal.ex.ac.uk/people/staff/mrwatkin/] Intersection of number-theory "pure"-maths WITH (Statistical)-Physics, as Siegel[AMS Joint.Mtg.(02)-Abs.973-60-124] Benford logarithmic-law algebraic-INVERSION to ONLY BEQS with d=0 digit P (d = 0) > = oogapFULBEC ! ! ! SiegelRiemann - hypothesisproofviaRayleigh [ Phil . Trans . CLXI (1870) ] - Polya [ Math . Ann . (21) ] - [ Random - WalksElectric - Nets . , MAA (81) ] - nderson [ PRL (58) ] - localization - Siegel [ Symp . Fractals , MRSFallMtg . (89) - 5 - papers ! ! ! ] FUZZYICS = CATEGORYICS : [ LOCALITY ]- MORPHISM / CROSSOVER / AUTMATHCAT / DIM - CAT / ANTONYM- > (GLOBALITY) FUNCTOR / SYNONYM / concomitancetonoise = / Fluct . - Dissip . theorem / FUNCTOR / SYNONYM / equivalence / proportionalityto = > generalized - susceptibilitypower - spectrum [ FLAT / FUNCTIONLESS / WHITE ]- MORPHISM / CROSSOVER / AUTMATHCAT / DIM - CAT / ANTONYM- > HYPERBOLICITY/ZIPF-law INEVITABILITY) intersection with ONLY BEQS BEC).
Semi-classical dynamics of superradiant Rayleigh scattering in a Bose-Einstein condensate
NASA Astrophysics Data System (ADS)
Müller, J. H.; Witthaut, D.; le Targat, R.; Arlt, J. J.; Polzik, E. S.; Hilliard, A. J.
2016-10-01
Due to its coherence properties and high optical depth, a Bose-Einstein condensate [BEC] provides an ideal setting to investigate collective atom-light interactions. Superradiant light scattering [SLS] in a BEC is a fascinating example of such an interaction. It is an analogous process to Dicke superradiance, in which an electronically inverted sample decays collectively, leading to the emission of one or more light pulses in a well-defined direction. Through time-resolved measurements of the superradiant light pulses emitted by an end-pumped BEC, we study the close connection of SLS with Dicke superradiance. A 1D model of the system yields good agreement with the experimental data and shows that the dynamics result from the structures that build up in the light and matter-wave fields along the BEC. This paves the way for exploiting the atom-photon correlations generated by the superradiance.
Vortex Lattices in the Bose-Fermi Superfluid Mixture.
Jiang, Yuzhu; Qi, Ran; Shi, Zhe-Yu; Zhai, Hui
2017-02-24
In this Letter we show that the vortex lattice structure in the Bose-Fermi superfluid mixture can undergo a sequence of structure transitions when the Fermi superfluid is tuned from the BCS regime to the BEC regime. This is due to the difference in the vortex core structure of a Fermi superfluid in the BCS regime and in the BEC regime. In the BCS regime the vortex core is nearly filled, while the density at the vortex core gradually decreases until it empties out in the BEC regime. Therefore, with the density-density interaction between the Bose and the Fermi superfluids, interaction between the two sets of vortex lattices gets stronger in the BEC regime, which yields the structure transition of vortex lattices. In view of the recent realization of this superfluid mixture and vortices therein, our theoretical predication can be verified experimentally in the near future.
Kairouz, Sylvia; Paradis, Catherine; Nadeau, Louise; Tovar, Marie-Line; Pousset, Maud
2016-12-01
Few empirical studies have examined the relationships between differing regulatory approaches and patterns of gambling behaviors. This article reports on a correlational cross-cultural comparison of differences in the regulatory approaches and gambling behavior among general adult populations in France and Québec, Canada. We drew data from two large population surveys conducted in France and Québec (N=27 653 and N=11 888, respectively). We found diverging and converging aspects of government regulatory policies. Statistical analyses demonstrated significantly higher participation rates and prevalence of 'assiduous gamblers' in Québec. In France, among assiduous gamblers, the proportion of moderate-risk and probable pathological gamblers is significantly higher. Future research should examine environmental conditions and varying gambling offerings, as well as gambling regulation, to determine their potential influence on gambling behaviors.
NASA Astrophysics Data System (ADS)
Cao, Gaoqing; He, Lianyi; Huang, Xu-Guang
2017-12-01
We present a theoretical study of the finite-temperature Kosterlitz-Thouless (KT) and vortex-antivortex lattice (VAL) melting transitions in two-dimensional Fermi gases with p - or d -wave pairing. For both pairings, when the interaction is tuned from weak to strong attractions, we observe a quantum phase transition from the Bardeen-Cooper-Schrieffer (BCS) superfluidity to the Bose-Einstein condensation (BEC) of difermions. The KT and VAL transition temperatures increase during this BCS-BEC transition and approach constant values in the deep BEC region. The BCS-BEC transition is characterized by the nonanalyticities of the chemical potential, the superfluid order parameter, and the sound velocities as functions of the interaction strength at both zero and finite temperatures; however, the temperature effect tends to weaken the nonanalyticities compared to the zero-temperature case. The effect of mismatched Fermi surfaces on the d -wave pairing is also studied.
NASA Astrophysics Data System (ADS)
van Wyk, Pieter; Inotani, Daisuke; Ohashi, Yoji
2018-03-01
We theoretically investigate the specific heat at constant volume C V in the BCS(Bardeen-Cooper-Schrieffer)-BEC(Bose-Einstein-condensation)-crossover regime of an ultracold Fermi gas, below the superfluid phase transition temperature T c. Within the strong-coupling framework developed by Nozières and Schmitt-Rink, we show that the temperature dependence of C V drastically changes as one passes through the crossover region, and is sensitive to strong fluctuations in the Cooper channel near the unitarity limit. We also compare our results to a recent experiment on a 6Li unitary Fermi gas. Since fluctuation effects are a crucial key in the BCS-BEC-crossover phenomenon, our results would be helpful in considering how the fermionic BCS superfluid changes into BEC with increasing the interaction strength, from the viewpoint of specific heat.
Magneto-optical Phase Transition in a Nanostructured Co/Pd Thin Film
NASA Astrophysics Data System (ADS)
Nwokoye, Chidubem; Bennett, Lawrence; Della Torre, Edward; Siddique, Abid; Zhang, Ming; Wagner, Michael; Narducci, Frank
Interest in the study of magnetism in nanostructures at low temperatures is growing. We report work that extends the magnetics experiments in that studied Bose-Einstein Condensation (BEC) of magnons in confined nanostructures. We report experimental investigation of the magneto-optical properties, influenced by photon-magnon interactions, of a Co/Pd thin film below and above the magnon BEC temperature. Comparison of results from SQUID and MOKE experiments revealed a phase transition temperature in both magnetic and magneto-optical properties of the material that is attributed to the magnon BEC. Recent research in magnonics has provided a realization scheme for developing magnon BEC qubit gates for a quantum computing processor. Future research work will explore this technology and find ways to apply quantum computing to address some computational challenges in communication systems. We recognize financial support from the Naval Air Systems Command Section 219 grant.
Pairing fluctuations and the superfluid density through the BCS-BEC crossover
DOE Office of Scientific and Technical Information (OSTI.GOV)
Taylor, E.; Griffin, A.; Fukushima, N.
2006-12-15
We derive an expression for the superfluid density of a uniform two-component Fermi gas through the BCS-BEC crossover in terms of the thermodynamic potential in the presence of an imposed superfluid flow. Treating the pairing fluctuations in a Gaussian approximation following the approach of Nozieres and Schmitt-Rink, we use this definition of {rho}{sub s} to obtain an explicit result which is valid at finite temperatures and over the full BCS-BEC crossover. It is crucial that the BCS gap {delta}, the chemical potential {mu}, and {rho}{sub s} all include the effect of fluctuations at the same level in a self-consistent manner.more » We show that the normal fluid density {rho}{sub n}{identical_to}n-{rho}{sub s} naturally separates into a sum of contributions from Fermi BCS quasiparticles ({rho}{sub n}{sup F}) and Bose collective modes ({rho}{sub n}{sup B}). The expression for {rho}{sub n}{sup F} is just Landau's formula for a BCS Fermi superfluid but now calculated over the BCS-BEC crossover. The expression for the Bose contribution {rho}{sub n}{sup B} is more complicated and only reduces to Landau's formula for a Bose superfluid in the extreme BEC limit, where all the fermions have formed stable Bose pairs and the Bogoliubov excitations of the associated molecular Bose condensate are undamped. In a companion paper, we present numerical calculations of {rho}{sub s} using an expression equivalent to the one derived in this paper, over the BCS-BEC crossover, including unitarity, and at finite temperatures.« less
2009-10-08
differentially pumped two-cell vacuum system. A gas of Rb atoms, provided by SAES dispensers, fills a glass cell where laser cooling and magneto - optic ...mask [Fig. 1(b)] that was imaged onto the center of the trap . The sum of the magnetic and optical potentials created a triple-well trap , with three... Simulations of BEC growth in a toroidal trap show vortices (as in (b),(c)) and persistent currents. 4 The merging of experimental capabilities. [ongoing work
Onsager Vortex Formation in Two-component Bose-Einstein Condensates
NASA Astrophysics Data System (ADS)
Han, Junsik; Tsubota, Makoto
2018-06-01
We numerically study the dynamics of quantized vortices in two-dimensional two-component Bose-Einstein condensates (BECs) trapped by a box potential. For one-component BECs in a box potential, it is known that quantized vortices form Onsager vortices, which are clusters of same-sign vortices. We confirm that the vortices of the two components spatially separate from each other — even for miscible two-component BECs — suppressing the formation of Onsager vortices. This phenomenon is caused by the repulsive interaction between vortices belonging to different components, hence, suggesting a new possibility for vortex phase separation.
Core structure of two-dimensional Fermi gas vortices in the BEC-BCS crossover region
DOE Office of Scientific and Technical Information (OSTI.GOV)
Madeira, Lucas; Gandolfi, Stefano; Schmidt, Kevin E.
2017-05-02
We report T = 0 diffusion Monte Carlo results for the ground-state and vortex excitation of unpolarized spin-1/2 fermions in a two-dimensional disk. We investigate how vortex core structure properties behave over the BEC-BCS crossover. We calculate the vortex excitation energy, density pro les, and vortex core properties related to the current. We nd a density suppression at the vortex core on the BCS side of the crossover and a depleted core on the BEC limit. Size-effect dependencies in the disk geometry were carefully studied.
Quantum Hall effect with small numbers of vortices in Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Byrnes, Tim; Dowling, Jonathan P.
2015-08-01
When vortices are displaced in Bose-Einstein condensates (BECs), the Magnus force gives the system a momentum transverse in the direction to the displacement. We show that BECs in long channels with vortices exhibit a quantization of the current response with respect to the spatial vortex distribution. The quantization originates from the well-known topological property of the phase around a vortex; it is an integer multiple of 2 π . In a way similar to that of the integer quantum Hall effect, the current along the channel is related to this topological phase and can be extracted from two experimentally measurable quantities: the total momentum of the BEC and the spatial distribution. The quantization is in units of m /2 h , where m is the mass of the atoms and h is Planck's constant. We derive an exact vortex momentum-displacement relation for BECs in long channels under general circumstances. Our results present the possibility that the configuration described here can be used as a novel way of measuring the mass of the atoms in the BEC using a topological invariant of the system. If an accurate determination of the plateaus are experimentally possible, this gives the possibility of a topological quantum mass standard and precise determination of the fine structure constant.
NASA Astrophysics Data System (ADS)
Timmermans, Eddy; Blinova, Alina; Boshier, Malcolm
2013-05-01
Polarons (particles that interact with the self-consistent deformation of the host medium that contains them) self-localize when strongly coupled. Dilute Bose-Einstein condensates (BECs) doped with neutral distinguishable atoms (impurities) and armed with a Feshbach-tuned impurity-boson interaction provide a unique laboratory to study self-localized polarons. In nature, self-localized polarons come in two flavors that exhibit qualitatively different behavior: In lattice systems, the deformation is slight and the particle is accompanied by a cloud of collective excitations as in the case of the Landau-Pekar polarons of electrons in a dielectric lattice. In natural fluids and gases, the strongly coupled particle radically alters the medium, e.g. by expelling the host medium as in the case of the electron bubbles in superfluid helium. We show that BEC-impurities can self-localize in a bubble, as well as in a Landau-Pekar polaron state. The BEC-impurity system is fully characterized by only two dimensionless coupling constants. In the corresponding phase diagram the bubble and Landau-Pekar polaron limits correspond to large islands separated by a cross-over region. The same BEC-impurity species can be adiabatically Feshbach steered from the Landau-Pekar to the bubble regime. This work was funded by the Los Alamos LDRD program.
Disorder effects in the evolution from BCS to BEC superfluidity
NASA Astrophysics Data System (ADS)
Han, Li; de Melo, Carlos A. R. Sa
2009-03-01
We discuss the effects of disorder on the critical temperature of superfluids during the evolution from BCS to BEC. For s-wave superfluids we find that the critical temperature is weakly affected by disorder in the BCS regime as described in Anderson’s theorem, even less affected by disorder at zero chemical potential (near unitarity), but strongly affected by disorder in the BEC regime, where Anderson's theorem does not apply. This suggests that the superfluid is more robust to the effects of disorder at the interaction parameter where the chemical potential vanishes (close to unitarity). We construct a three dimensional phase diagram of critical temperature, disorder and interaction parameter [1], and show that there are regions of localized superfluidity, as well as insulating regions due to Anderson localization of fermions (BCS regime) and molecular bosons (BEC regime). The phase diagram for higher angular momentum (e.g. p-wave and d-wave) is also analyzed, where the effects of disorder are much more dramatic in the BCS regime in comparison to the s-wave case because pair breaking is strong, while the disorder effects in BEC regime are similar to what occurs in the s-wave case. [1] Li Han, C. A. R. Sa de Melo, arXiv:0812.xxxx
The BCS-BEC crossover: From ultra-cold Fermi gases to nuclear systems
NASA Astrophysics Data System (ADS)
Strinati, Giancarlo Calvanese; Pieri, Pierbiagio; Röpke, Gerd; Schuck, Peter; Urban, Michael
2018-04-01
This report addresses topics and questions of common interest in the fields of ultra-cold gases and nuclear physics in the context of the BCS-BEC crossover. By this crossover, the phenomena of Bardeen-Cooper-Schrieffer (BCS) superfluidity and Bose-Einstein condensation (BEC), which share the same kind of spontaneous symmetry breaking, are smoothly connected through the progressive reduction of the size of the fermion pairs involved as the fundamental entities in both phenomena. This size ranges, from large values when Cooper pairs are strongly overlapping in the BCS limit of a weak inter-particle attraction, to small values when composite bosons are non-overlapping in the BEC limit of a strong inter-particle attraction, across the intermediate unitarity limit where the size of the pairs is comparable with the average inter-particle distance. The BCS-BEC crossover has recently been realized experimentally, and essentially in all of its aspects, with ultra-cold Fermi gases. This realization, in turn, has raised the interest of the nuclear physics community in the crossover problem, since it represents an unprecedented tool to test fundamental and unanswered questions of nuclear many-body theory. Here, we focus on the several aspects of the BCS-BEC crossover, which are of broad joint interest to both ultra-cold Fermi gases and nuclear matter, and which will likely help to solve in the future some open problems in nuclear physics (concerning, for instance, neutron stars). Similarities and differences occurring in ultra-cold Fermi gases and nuclear matter will then be emphasized, not only about the relative phenomenologies but also about the theoretical approaches to be used in the two contexts. Common to both contexts is the fact that at zero temperature the BCS-BEC crossover can be described at the mean-field level with reasonable accuracy. At finite temperature, on the other hand, inclusion of pairing fluctuations beyond mean field represents an essential ingredient of the theory, especially in the normal phase where they account for precursor pairing effects. After an introduction to present the key concepts of the BCS-BEC crossover, this report discusses the mean-field treatment of the superfluid phase, both for homogeneous and inhomogeneous systems, as well as for symmetric (spin- or isospin-balanced) and asymmetric (spin- or isospin-imbalanced) matter. Pairing fluctuations in the normal phase are then considered, with their manifestations in thermodynamic and dynamic quantities. The last two Sections provide a more specialized discussion of the BCS-BEC crossover in ultra-cold Fermi gases and nuclear matter, respectively. The separate discussion in the two contexts aims at cross communicating to both communities topics and aspects which, albeit arising in one of the two fields, share a strong common interest.
Southern Québec in Late Winter
2002-02-27
These images of Canada Québec province were acquired by NASA Terra satelliteon March 4, 2001.The region forests are a mixture of coniferous and hardwood trees, and ugar-shack festivities are held at this time of year to celebrate the beginning o
Testing the Bose-Einstein Condensate dark matter model at galactic cluster scale
DOE Office of Scientific and Technical Information (OSTI.GOV)
Harko, Tiberiu; Liang, Pengxiang; Liang, Shi-Dong
The possibility that dark matter may be in the form of a Bose-Einstein Condensate (BEC) has been extensively explored at galactic scale. In particular, good fits for the galactic rotations curves have been obtained, and upper limits for the dark matter particle mass and scattering length have been estimated. In the present paper we extend the investigation of the properties of the BEC dark matter to the galactic cluster scale, involving dark matter dominated astrophysical systems formed of thousands of galaxies each. By considering that one of the major components of a galactic cluster, the intra-cluster hot gas, is describedmore » by King's β-model, and that both intra-cluster gas and dark matter are in hydrostatic equilibrium, bound by the same total mass profile, we derive the mass and density profiles of the BEC dark matter. In our analysis we consider several theoretical models, corresponding to isothermal hot gas and zero temperature BEC dark matter, non-isothermal gas and zero temperature dark matter, and isothermal gas and finite temperature BEC, respectively. The properties of the finite temperature BEC dark matter cluster are investigated in detail numerically. We compare our theoretical results with the observational data of 106 galactic clusters. Using a least-squares fitting, as well as the observational results for the dark matter self-interaction cross section, we obtain some upper bounds for the mass and scattering length of the dark matter particle. Our results suggest that the mass of the dark matter particle is of the order of μ eV, while the scattering length has values in the range of 10{sup −7} fm.« less
Clarke, Douglas N.; Al Ahmad, Abraham; Lee, Boyeon; Parham, Christi; Auckland, Lisa; Fertala, Andrezj; Kahle, Michael; Shaw, Courtney S.; Roberts, Jill; Bix, Gregory J.
2012-01-01
Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α5β1 integrin, identify the downstream signal transduction pathway, and further investigate the functional significance of resultant VEGF release. Interestingly, we found that the LG3 portion of DV, which has been suggested to possess most of DV’s angio-modulatory activity outside of the brain, binds poorly to α5β1 and induces less BEC proliferation compared to full length DV. Additionally, we implicate DV’s DGR sequence as an important element for the interaction of DV with α5β1. Furthermore, we investigated the importance of AKT and ERK signaling in DV-induced VEGF expression and secretion. We show that DV increases the phosphorylation of ERK, which leads to subsequent activation and stabilization of eIF4E and HIF-1α. Inhibition of ERK activity by U0126 suppressed DV-induced expression and secretion of VEGR in BECs. While DV was capable of phosphorylating AKT we show that AKT phosphorylation does not play a role in DV’s induction of VEGF expression or secretion using two separate inhibitors, LY294002 and Akt IV. Lastly, we demonstrate that VEGF activity is critical for DV increases in BEC proliferation, as well as angiogenesis in a BEC-neuronal co-culture system. Collectively, our findings expand our understanding of DV’s mechanism of action on BECs, and further support its potential as a novel stroke therapy. PMID:23028886
Hernández-Zavala, Araceli; Valenzuela, Olga L; Matousek, Tomás; Drobná, Zuzana; Dĕdina, Jirí; García-Vargas, Gonzalo G; Thomas, David J; Del Razo, Luz M; Stýblo, Miroslav
2008-12-01
The concentration of arsenic in urine has been used as a marker of exposure to inorganic As (iAs). Relative proportions of urinary metabolites of iAs have been identified as potential biomarkers of susceptibility to iAs toxicity. However, the adverse effects of iAs exposure are ultimately determined by the concentrations of iAs metabolites in target tissues. In this study we examined the feasibility of analyzing As species in cells that originate in the urinary bladder, a target organ for As-induced cancer in humans. Exfoliated bladder epithelial cells (BECs) were collected from urine of 21 residents of Zimapan, Mexico, who were exposed to iAs in drinking water. We determined concentrations of iAs, methyl-As (MAs), and dimethyl-As (DMAs) in urine using conventional hydride generation-cryotrapping-atomic absorption spectrometry (HG-CT-AAS). We used an optimized HG-CT-AAS technique with detection limits of 12-17 pg As for analysis of As species in BECs. All urine samples and 20 of 21 BEC samples contained detectable concentrations of iAs, MAs, and DMAs. Sums of concentrations of these As species in BECs ranged from 0.18 to 11.4 ng As/mg protein and in urine from 4.8 to 1,947 ng As/mL. We found no correlations between the concentrations or ratios of As species in BECs and in urine. These results suggest that urinary levels of iAs metabolites do not necessarily reflect levels of these metabolites in the bladder epithelium. Thus, analysis of As species in BECs may provide a more effective tool for risk assessment of bladder cancer and other urothelial diseases associated with exposures to iAs.
77 FR 58787 - Airworthiness Directives; Bombardier, Inc. Airplanes
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2012-09-24
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-19
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-31
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Network-Physics(NP) Bec DIGITAL(#)-VULNERABILITY Versus Fault-Tolerant Analog
NASA Astrophysics Data System (ADS)
Alexander, G. K.; Hathaway, M.; Schmidt, H. E.; Siegel, E.
2011-03-01
Siegel[AMS Joint Mtg.(2002)-Abs.973-60-124] digits logarithmic-(Newcomb(1881)-Weyl(1914; 1916)-Benford(1938)-"NeWBe"/"OLDbe")-law algebraic-inversion to ONLY BEQS BEC:Quanta/Bosons= digits: Synthesis reveals EMP-like SEVERE VULNERABILITY of ONLY DIGITAL-networks(VS. FAULT-TOLERANT ANALOG INvulnerability) via Barabasi "Network-Physics" relative-``statics''(VS.dynamics-[Willinger-Alderson-Doyle(Not.AMS(5/09)]-]critique); (so called)"Quantum-computing is simple-arithmetic(sans division/ factorization); algorithmic-complexities: INtractibility/ UNdecidability/ INefficiency/NONcomputability / HARDNESS(so MIScalled) "noise"-induced-phase-transitions(NITS) ACCELERATION: Cook-Levin theorem Reducibility is Renormalization-(Semi)-Group fixed-points; number-Randomness DEFINITION via WHAT? Query(VS. Goldreich[Not.AMS(02)] How? mea culpa)can ONLY be MBCS "hot-plasma" versus digit-clumping NON-random BEC; Modular-arithmetic Congruences= Signal X Noise PRODUCTS = clock-model; NON-Shor[Physica A,341,586(04)] BEC logarithmic-law inversion factorization:Watkins number-thy. U stat.-phys.); P=/=NP TRIVIAL Proof: Euclid!!! [(So Miscalled) computational-complexity J-O obviation via geometry.
Quantum decoherence of phonons in Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Howl, Richard; Sabín, Carlos; Hackermüller, Lucia; Fuentes, Ivette
2018-01-01
We apply modern techniques from quantum optics and quantum information science to Bose-Einstein condensates (BECs) in order to study, for the first time, the quantum decoherence of phonons of isolated BECs. In the last few years, major advances in the manipulation and control of phonons have highlighted their potential as carriers of quantum information in quantum technologies, particularly in quantum processing and quantum communication. Although most of these studies have focused on trapped ion and crystalline systems, another promising system that has remained relatively unexplored is BECs. The potential benefits in using this system have been emphasized recently with proposals of relativistic quantum devices that exploit quantum states of phonons in BECs to achieve, in principle, superior performance over standard non-relativistic devices. Quantum decoherence is often the limiting factor in the practical realization of quantum technologies, but here we show that quantum decoherence of phonons is not expected to heavily constrain the performance of these proposed relativistic quantum devices.
Ames, Kristina; Da Cunha, Dayse S; Gonzalez, Brenda; Konta, Marina; Lin, Feng; Shechter, Gabriel; Starikov, Lev; Wong, Sara; Bülow, Hannes E; Meléndez, Alicia
2017-03-20
The decision of stem cells to proliferate and differentiate is finely controlled. The Caenorhabditis elegans germline provides a tractable system for studying the mechanisms that control stem cell proliferation and homeostasis [1-4]. Autophagy is a conserved cellular recycling process crucial for cellular homeostasis in many different contexts [5], but its function in germline stem cell proliferation remains poorly understood. Here, we describe a function for autophagy in germline stem cell proliferation. We found that autophagy genes such as bec-1/BECN1/Beclin1, atg-16.2/ATG16L, atg-18/WIPI1/2, and atg-7/ATG7 are required for the late larval expansion of germline stem cell progenitors in the C. elegans gonad. We further show that BEC-1/BECN1/Beclin1 acts independently of the GLP-1/Notch or DAF-7/TGF-β pathways but together with the DAF-2/insulin IGF-1 receptor (IIR) signaling pathway to promote germline stem cell proliferation. Similar to DAF-2/IIR, BEC-1/BECN1/Beclin1, ATG-18/WIPI1/2, and ATG-16.2/ATG16L all promote cell-cycle progression and are negatively regulated by the phosphatase and tensin homolog DAF-18/PTEN. However, whereas BEC-1/BECN1/Beclin1 acts through the transcriptional regulator SKN-1/Nrf1, ATG-18/WIPI1/2 and ATG-16.2/ATG16L exert their function through the DAF-16/FOXO transcription factor. In contrast, ATG-7 functions in concert with the DAF-7/TGF-β pathway to promote germline proliferation and is not required for cell-cycle progression. Finally, we report that BEC-1/BECN1/Beclin1 functions non-cell-autonomously to facilitate cell-cycle progression and stem cell proliferation. Our findings demonstrate a novel non-autonomous role for BEC-1/BECN1/Beclin1 in the control of stem cell proliferation and cell-cycle progression, which may have implications for the understanding and development of therapies against malignant cell growth in the future. Copyright © 2017 Elsevier Ltd. All rights reserved.
Development and validation of parenting measures for body image and eating patterns in childhood.
Damiano, Stephanie R; Hart, Laura M; Paxton, Susan J
2015-01-01
Evidence-based parenting interventions are important in assisting parents to help their children develop healthy body image and eating patterns. To adequately assess the impact of parenting interventions, valid parent measures are required. The aim of this study was to develop and assess the validity and reliability of two new parent measures, the Parenting Intentions for Body image and Eating patterns in Childhood (Parenting Intentions BEC) and the Knowledge Test for Body image and Eating patterns in Childhood (Knowledge Test BEC). Participants were 27 professionals working in research or clinical treatment of body dissatisfaction or eating disorders, and 75 parents of children aged 2-6 years, who completed the measures via an online questionnaire. Seven scenarios were developed for the Parenting Intentions BEC to describe common experiences about the body and food that parents might need to respond to in front of their child. Parents ranked four behavioural intentions, derived from the current literature on parenting risk factors for body dissatisfaction and unhealthy eating patterns in children. Two subscales were created, one representing positive behavioural intentions, the other negative behavioural intentions. After piloting a larger pool of items, 13 statements were used to construct the Knowledge Test BEC. These were designed to be factual statements about the influence of parent language, media, family meals, healthy eating, and self-esteem on child eating and body image. The validity of both measures was tested by comparing parent and professional scores, and reliability was assessed by comparing parent scores over two testing occasions. Compared with parents, professionals reported significantly higher scores on the Positive Intentions subscale and significantly lower on the Negative Intentions subscale of the Parenting Intentions BEC; confirming the discriminant validity of six out of the seven scenarios. Test-retest reliability was also confirmed as parent scores on the two Parenting Intentions subscales did not differ over time. Eleven out of the 13 Knowledge Test items demonstrated sufficient discriminant validity and test-retest reliability. Overall, results indicated that the six-scenario Parenting Intentions BEC and the 11-item Knowledge Test BEC are valid and reliable measures for parents of young children.
Dispersion Engineering of Bose-Einstein Condensates
NASA Astrophysics Data System (ADS)
Khamehchi, Mohammad Amin
The subject of this dissertation is engineering the dispersion relation for dilute Bose-Einstein condensates (BECs). When a BEC is immersed into suitably tailored laser fields its dispersion can be strongly modified. Prominent examples for such laser fields include optical lattice geometries and Raman dressing fields. The ability to engineer the dispersion of a BEC allows for the investigation of a range of phenomena related to quantum hydrodynamics and condensed matter. In the first context, this dissertation studies the excitation spectrum of a spin-orbit coupled (SOC) BEC. The spin-orbit coupling is generated by " dressing" the atoms with two Raman laser fields. The excitation spectrum has a Roton-like feature that can be altered by tuning the Raman laser parameters. It is demonstrated that the Roton mode can be softened, but it does not reach the ground state energy for the experimental conditions we had. Furthermore, the expansion of SOC BECs in 1D is studied by relaxing the trap allowing the BEC to expand in the SOC direction. Contrary to the findings for optical lattices, it is observed that the condensate partially occupies quasimomentum states with negative effective mass, and therefore an abrupt deceleration is observed although the mean field force is along the direction of expansion. In condensed-matter systems, a periodic lattice structure often plays an important role. In this context, an alternative to the Raman dressing scheme can be realized by coupling the s- and p- bands of a static optical lattice via a weak moving lattice. The bands can be treated as pseudo-spin states. It is shown that similar to the dispersion relation of a Raman dressed SOC, the quasimomentum of the ground state is different from zero. Coherent coupling of the SOC dispersion minima can lead to the realization of the stripe phase even though it is not the thermodynamic ground state of the system. Along the lines of studying the hydrodynamics of BECs, three novel multicomponent solitonic states are realized. It is shown that the solitons are structurally stable and the oscillation of vector dark-anti-dark solitons is studied in a weak harmonic trap.
Demircigil, Gonca Çakmak; Erdem, Onur; Gaga, Eftade O; Altuğ, Hicran; Demirel, Gülçin; Özden, Özlem; Arı, Akif; Örnektekin, Sermin; Döğeroğlu, Tuncay; van Doorn, Wim; Burgaz, Sema
2014-01-01
There is an increasing attempt in the world to determine the exposures of children to environmental chemicals. To analyze the genotoxic effect of air pollution, micronucleus (MN) assay was carried out in buccal epithelial cells (BECs) of children living in an urban city of Turkey. Children from two schools at urban-traffic and suburban sites were investigated in summer and winter seasons for the determination of BEC-MN frequency (per mille) and frequency of BEC with MN (per mille). The same children were also recruited for lung function measurements within a MATRA project ("Together Towards Clean Air in Eskisehir and Iskenderun") Measured NO2 and SO2 concentrations did not exceed the European Union (EU) limit levels either in urban-traffic or suburban regions. Higher O3 concentrations were measured in the suburban site especially in the summer period. Particulate matter (PM2.5 and PM10) levels which did not differ statistically between two regions were above the EU limits in general. Although BEC-MN frequencies of children living in the suburban sites were higher in general, the difference between two regions was not significant either in the summer or winter periods. BEC-MN frequencies of the urban-traffic children were found to be significantly higher in summer period (mean ± SD, 2.68 ± 1.99) when compared to winter period (1.64 ± 1.59; p = 0.004). On the other hand, no seasonality was observed for the suburban children. Similar results have been obtained in the BEC frequency with MN in our study. In summer, BEC-MN frequencies were significantly increased with the decrease in pulmonary function levels based on forced expiratory flow between 25 and 75% of vital capacity (FEF25-75%) levels (p < 0.05). As a conclusion, children living in urban-traffic and suburban areas in the city of Eskişehir exhibited similar genotoxicity. Seasonal variation in genotoxicity may be interpreted as relatively high ozone levels and increasing time spent at outdoors in the summer.
Scaranelo, Anabel M; Carrillo, Maria Claudia; Fleming, Rachel; Jacks, Lindsay M; Kulkarni, Supriya R; Crystal, Pavel
2013-06-01
To perform semiautomated quantitative analysis of the background enhancement (BE) in a cohort of patients with newly diagnosed breast cancer and to correlate it with mammographic breast density and menstrual cycle. Informed consent was waived after the research ethics board approved this study. Results of 177 consecutive preoperative breast magnetic resonance (MR) examinations performed from February to December 2009 were reviewed; 147 female patients (median age, 48 years; range, 26-86 years) were included. Ordinal values of BE and breast density were described by two independent readers by using the Breast Imaging Reporting and Data System lexicon. The BE coefficient (BEC) was calculated thus: (SI2 · 100/SI1) - 100, where SI is signal intensity, SI2 is the SI enhancement measured in the largest anteroposterior dimension in the axial plane 1 minute after the contrast agent injection, and SI1is the SI before contrast agent injection. BEC was used for the quantitative analysis of BE. Menstrual cycle status was based on the last menstrual period. The Wilcoxon rank-sum or Kruskal-Wallis test was used to compare quantitative assessment groups. Cohen weighted κ was used to evaluate agreement. Of 147 patients, 68 (46%) were premenopausal and 79 (54%) were postmenopausal. The quantitative BEC was associated with the menstrual status (BEC in premenopausal women, 31.48 ± 20.68 [standard deviation]; BEC in postmenopausal women, 25.65 ± 16.74; P = .02). The percentage of overall BE was higher when the MR imaging was performed in women in the inadequate phase of the cycle (<35 days, not 7-14 days; mean BEC, 35.7) compared with women in the postmenopausal group (P = .001). Premenopausal women had significantly higher BEC when compared with postmenopausal women (P = .03). There was no significant difference in the percentage of BE between breast density groups. Premenopausal women with breast cancer, and specifically women in the inadequate phase of the cycle, presented with higher quantitative BE than postmenopausal women. No association was found between BE and breast density.
Drewlo, Sascha; Brämer, Christian O.; Madkour, Mohamed; Mayer, Frank; Steinbüchel, Alexander
2001-01-01
On complex medium Escherichia coli strains carrying hybrid plasmid pBEC/EE:11.0, pSKBEC/BE:9.0, pSKBEC/PP:3.3, or pSKBEC/PP:2.4 harboring genomic DNA of Ralstonia eutropha HF39 produced a blue pigment characterized as indigo by several chemical and spectroscopic methods. A 1,251-bp open reading frame (bec) was cloned and sequenced. The deduced amino acid sequence of bec showed only weak similarities to short-chain acyl-coenzyme A dehydrogenases, and the gene product catalyzed formation of indoxyl, a reactive preliminary stage for production of indigo. PMID:11282658
Dynamics of nonautonomous rogue waves in Bose-Einstein condensate
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zhao, Li-Chen, E-mail: zhaolichen3@163.com
2013-02-15
We study rogue waves of Bose-Einstein condensate (BEC) analytically in a time-dependent harmonic trap with a complex potential. Properties of the nonautonomous rogue waves are investigated analytically. It is reported that there are possibilities to 'catch' rogue waves through manipulating nonlinear interaction properly. The results provide many possibilities to manipulate rogue waves experimentally in a BEC system. - Highlights: Black-Right-Pointing-Pointer One more generalized rogue wave solutions are presented. Black-Right-Pointing-Pointer Present one possible way to catch a rouge wave. Black-Right-Pointing-Pointer Properties of rogue waves are investigated analytically for the first time. Black-Right-Pointing-Pointer Provide many possibilities to manipulate rogue waves in BEC.
Quantum synchronization of chaotic oscillator behaviors among coupled BEC-optomechanical systems
NASA Astrophysics Data System (ADS)
Li, Wenlin; Li, Chong; Song, Heshan
2017-03-01
We consider and theoretically analyze a Bose-Einstein condensate (BEC) trapped inside an optomechanical system consisting of single-mode optical cavity with a moving end mirror. The BEC is formally analogous to a mirror driven by radiation pressure with strong nonlinear coupling. Such a nonlinear enhancement can make the oscillator display chaotic behavior. By establishing proper oscillator couplings, we find that this chaotic motion can be synchronized with other oscillators, even an oscillator network. We also discuss the scheme feasibility by analyzing recent experiment parameters. Our results provide a promising platform for the quantum signal transmission and quantum logic control, and they are of potential applications in quantum information processing and quantum networks.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hanai, R.; Littlewood, P. B.; Ohashi, Y.
2016-03-01
We theoretically investigate a Bose-condensed exciton gas out of equilibrium. Within the framework of the combined BCS-Leggett strong-coupling theory with the non-equilibrium Keldysh formalism, we show how the Bose-Einstein condensation (BEC) of excitons is suppressed to eventually disappear, when the system is in the non-equilibrium steady state. The supply of electrons and holes from the bath is shown to induce quasi-particle excitations, leading to the partial occupation of the upper branch of Bogoliubov single-particle excitation spectrum. We also discuss how this quasi-particle induction is related to the suppression of exciton BEC, as well as the stability of the steady state.
Fifteen years of cold matter on the atom chip: promise, realizations, and prospects
Keil, Mark; Amit, Omer; Zhou, Shuyu; Groswasser, David; Japha, Yonathan; Folman, Ron
2016-01-01
Here we review the field of atom chips in the context of Bose–Einstein Condensates (BEC) as well as cold matter in general. Twenty years after the first realization of the BEC and 15 years after the realization of the atom chip, the latter has been found to enable extraordinary feats: from producing BECs at a rate of several per second, through the realization of matter-wave interferometry, and all the way to novel probing of surfaces and new forces. In addition, technological applications are also being intensively pursued. This review will describe these developments and more, including new ideas which have not yet been realized. PMID:27499585
Attractive Hubbard model with disorder and the generalized Anderson theorem
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kuchinskii, E. Z., E-mail: kuchinsk@iep.uran.ru; Kuleeva, N. A., E-mail: strigina@iep.uran.ru; Sadovskii, M. V., E-mail: sadovski@iep.uran.ru
Using the generalized DMFT+Σ approach, we study the influence of disorder on single-particle properties of the normal phase and the superconducting transition temperature in the attractive Hubbard model. A wide range of attractive potentials U is studied, from the weak coupling region, where both the instability of the normal phase and superconductivity are well described by the BCS model, to the strong-coupling region, where the superconducting transition is due to Bose-Einstein condensation (BEC) of compact Cooper pairs, formed at temperatures much higher than the superconducting transition temperature. We study two typical models of the conduction band with semi-elliptic and flatmore » densities of states, respectively appropriate for three-dimensional and two-dimensional systems. For the semi-elliptic density of states, the disorder influence on all single-particle properties (e.g., density of states) is universal for an arbitrary strength of electronic correlations and disorder and is due to only the general disorder widening of the conduction band. In the case of a flat density of states, universality is absent in the general case, but still the disorder influence is mainly due to band widening, and the universal behavior is restored for large enough disorder. Using the combination of DMFT+Σ and Nozieres-Schmitt-Rink approximations, we study the disorder influence on the superconducting transition temperature T{sub c} for a range of characteristic values of U and disorder, including the BCS-BEC crossover region and the limit of strong-coupling. Disorder can either suppress T{sub c} (in the weak-coupling region) or significantly increase T{sub c} (in the strong-coupling region). However, in all cases, the generalized Anderson theorem is valid and all changes of the superconducting critical temperature are essentially due to only the general disorder widening of the conduction band.« less
The Pedagogical Practices of Québec High School Teachers Relative to Sexual Diversity
ERIC Educational Resources Information Center
Richard, Gabrielle
2015-01-01
This article explores the ways in which teachers describe their pedagogical and intervention practices relative to sexual diversity in Québec (Canada). Three variables closely associated with teachers who report inclusive practices emerge: experiential training (based on the experience of a lesbian, gay, or bisexual [LGB] teacher), contact…
Economic Understanding and BEC National Level Students. Research Papers in Economics Education.
ERIC Educational Resources Information Center
King, Barrie
The implementation of a unified national system of non-degree courses in business administration, the Business Economic Council (BEC) courses, replaced the ordinary national diploma and certificate courses in business administration in British colleges in the 1970's. Widespread faculty concern that these new courses have not been providing…
Thinking Interculturally: Decolonizing History and Citizenship Education in Québec
ERIC Educational Resources Information Center
DesRoches, Sarah J.
2016-01-01
The main objective of this article is to offer an alternative discursive framework for teaching history and citizenship education in Québec, Canada. Enabling a more inclusive discussion around how citizenship is constructed, thinking interculturally allows us begin thinking about practical ways in which citizenship and history education might…
A projection gradient method for computing ground state of spin-2 Bose–Einstein condensates
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wang, Hanquan, E-mail: hanquan.wang@gmail.com; Yunnan Tongchang Scientific Computing and Data Mining Research Center, Kunming, Yunnan Province, 650221
In this paper, a projection gradient method is presented for computing ground state of spin-2 Bose–Einstein condensates (BEC). We first propose the general projection gradient method for solving energy functional minimization problem under multiple constraints, in which the energy functional takes real functions as independent variables. We next extend the method to solve a similar problem, where the energy functional now takes complex functions as independent variables. We finally employ the method into finding the ground state of spin-2 BEC. The key of our method is: by constructing continuous gradient flows (CGFs), the ground state of spin-2 BEC can bemore » computed as the steady state solution of such CGFs. We discretized the CGFs by a conservative finite difference method along with a proper way to deal with the nonlinear terms. We show that the numerical discretization is normalization and magnetization conservative and energy diminishing. Numerical results of the ground state and their energy of spin-2 BEC are reported to demonstrate the effectiveness of the numerical method.« less
Shock Waves in a Bose-Einstein Condensate
NASA Technical Reports Server (NTRS)
Kulikov, Igor; Zak, Michail
2005-01-01
A paper presents a theoretical study of shock waves in a trapped Bose-Einstein condensate (BEC). The mathematical model of the BEC in this study is a nonlinear Schroedinger equation (NLSE) in which (1) the role of the wave function of a single particle in the traditional Schroedinger equation is played by a space- and time-dependent complex order parameter (x,t) proportional to the square root of the density of atoms and (2) the atoms engage in a repulsive interaction characterized by a potential proportional to | (x,t)|2. Equations that describe macroscopic perturbations of the BEC at zero temperature are derived from the NLSE and simplifying assumptions are made, leading to equations for the propagation of sound waves and the transformation of sound waves into shock waves. Equations for the speeds of shock waves and the relationships between jumps of velocity and density across shock fronts are derived. Similarities and differences between this theory and the classical theory of sound waves and shocks in ordinary gases are noted. The present theory is illustrated by solving the equations for the example of a shock wave propagating in a cigar-shaped BEC.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Watanabe, Ryota; Tsuchiya, Shunji; CREST
2010-10-15
We investigate single-particle excitations and strong-coupling effects in the BCS-BEC crossover regime of a superfluid Fermi gas. Including phase and amplitude fluctuations of the superfluid order parameter within a T-matrix theory, we calculate the superfluid density of states (DOS), as well as single-particle spectral weight, over the entire BCS-BEC crossover region below the superfluid transition temperature T{sub c}. We clarify how the pseudogap in the normal state evolves into the superfluid gap, as one passes through T{sub c}. While the pseudogap in DOS continuously evolves into the superfluid gap in the weak-coupling BCS regime, the superfluid gap in the crossovermore » region is shown to appear in DOS after the pseudogap disappears below T{sub c}. In the phase diagram with respect to the temperature and interaction strength, we determine the region where strong pairing fluctuations dominate over single-particle properties of the system. Our results would be useful for the study of strong-coupling phenomena in the BCS-BEC crossover regime of a superfluid Fermi gas.« less
Novel LRPPRC Mutation in a Boy With Mild Leigh Syndrome, French-Canadian Type Outside of Québec.
Han, Velda Xinying; Tan, Teresa S; Wang, Furene S; Tay, Stacey Kiat-Hong
2017-01-01
Leigh syndrome, French-Canadian type is unique to patients from a genetic isolate in the Saguenay-Lac-Saint-Jean region of Québec. It has also been recently described in 10 patients with LRPPRC mutation outside of Québec. It is an autosomal recessive genetic disorder with fatal metabolic crisis and severe neurological morbidity in infancy caused by LRPPRC mutation. The authors report a boy with a novel LRPPRC compound heterozygous missense mutations c.3130C>T, c.3430C>T, and c.4078G>A found on whole-exome sequencing which correlated with isolated cytochrome c-oxidase deficiency found in skeletal muscle. LRPPRC mutation is a rare cause of cytochrome c-oxidase-deficient form of Leigh syndrome outside of Québec. Our patient broadens the spectrum of phenotypes of Leigh syndrome, French-Canadian type. LRPPRC mutation should be considered in children with early childhood neurodegenerative disorder, even in the absence of metabolic crisis. Early evaluation with whole-exome sequencing is useful for early diagnosis and for genetic counseling.
An effective public health program to reduce urban heat islands in Québec, Canada.
Beaudoin, Mélanie; Gosselin, Pierre
2016-09-01
In 2005, the Government of the Province of Québec, Canada, adopted the Climate Change Action Plan for 2006 - 2012. The Institut national de santé publique du Québec (National Institute of Public Health of Québec), charged with implementing the health adaptation component of the Plan, worked to mitigate urban heat islands (UHI) by funding and evaluating 40 pilot projects. These projects explored different methods of fighting UHIs by greening cities in a participative and mobilizing approach led mainly by non-governmental organizations and municipalities. An assessment of temperatures before and after implementing various methods demonstrated that some actions enabled significant gains of coolness and more efficiently mitigated heat (reduction of concrete/asphalt surfaces, increasing vegetation, etc.). An assessment of quality of life showed that projects were positively received by users, especially by those living in vulnerable situations. A lifecycle analysis showed that from the environmental perspective, UHI mitigation measures that do not require fertilization or maintenance are preferable. Finally, communication efforts that raise awareness of UHI and mitigation are of significant importance to program success.
NASA Astrophysics Data System (ADS)
Nakamura, K.
Bose-Einstein condensate(BEC) provides a nice stage when the nonlinearSchrödinger equation plays a vital role. We study the dynamics of multi-component repulsive BEC in 2 dimensions with harmonic traps by using the nonlinear Schrödinger (or Gross-Pitaevskii) equation. Firstly we consider a driven two-component BEC with each component trapped in different vertical positions. The appropriate tuning of the oscillation frequency of the magnetic field leads to a striking anti-gravity transport of BEC. This phenomenon is a manifestation of macroscopic non-adiabatic tunneling in a system with two internal(electronic) degrees of freedom. The dynamics splits into a fast complex spatio-temporal oscillation of each condensate wavefunctions together with a slow levitation of the total center of mass. Secondly, we examine the three-component repulsive BEC in 2 dimensions in a harmonic trap in the absence of magnetic field, and construct a model of conservative chaos based on a picture of vortex molecules. We obtain an effective nonlinear dynamics for three vortex cores, which represents three charged particles under the uniform magnetic field with the repulsive inter-particle potential quadratic in the inter-vortex distance r_{ij} on short scale and logarithmic in r_{ij} on large scale. The vortices here acquire the inertia in marked contrast to the standard theory of point vortices since Onsager. We then explore ``the chaos in the three-body problem" in the context of vortices with inertia.
Superfluid density and condensate fraction in the BCS-BEC crossover regime at finite temperatures
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fukushima, N.; Ohashi, Y.; Faculty of Science and Technology, Keio University, Hiyoshi, Yokohama 223
2007-03-15
The superfluid density is a fundamental quantity describing the response to a rotation as well as in two-fluid collisional hydrodynamics. We present extensive calculations of the superfluid density {rho}{sub s} in the BCS-BEC crossover regime of a uniform superfluid Fermi gas at finite temperatures. We include strong-coupling or fluctuation effects on these quantities within a Gaussian approximation. We also incorporate the same fluctuation effects into the BCS single-particle excitations described by the superfluid order parameter {delta} and Fermi chemical potential {mu}, using the Nozieres-Schmitt-Rink approximation. This treatment is shown to be necessary for consistent treatment of {rho}{sub s} over themore » entire BCS-BEC crossover. We also calculate the condensate fraction N{sub c} as a function of the temperature, a quantity which is quite different from the superfluid density {rho}{sub s}. We show that the mean-field expression for the condensate fraction N{sub c} is a good approximation even in the strong-coupling BEC regime. Our numerical results show how {rho}{sub s} and N{sub c} depend on temperature, from the weak-coupling BCS region to the BEC region of tightly bound Cooper pair molecules. In a companion paper [Phys. Rev. A 74, 063626 (2006)], we derive an equivalent expression for {rho}{sub s} from the thermodynamic potential, which exhibits the role of the pairing fluctuations in a more explicit manner.« less
Nielsen, Simone S E; Siupka, Piotr; Georgian, Ana; Preston, Jane E; Tóth, Andrea E; Yusof, Siti R; Abbott, N Joan; Nielsen, Morten S
2017-09-24
The aim of this protocol presents an optimized procedure for the purification and cultivation of pBECs and to establish in vitro blood-brain barrier (BBB) models based on pBECs in mono-culture (MC), MC with astrocyte-conditioned medium (ACM), and non-contact co-culture (NCC) with astrocytes of porcine or rat origin. pBECs were isolated and cultured from fragments of capillaries from the brain cortices of domestic pigs 5-6 months old. These fragments were purified by careful removal of meninges, isolation and homogenization of grey matter, filtration, enzymatic digestion, and centrifugation. To further eliminate contaminating cells, the capillary fragments were cultured with puromycin-containing medium. When 60-95% confluent, pBECs growing from the capillary fragments were passaged to permeable membrane filter inserts and established in the models. To increase barrier tightness and BBB characteristic phenotype of pBECs, the cells were treated with the following differentiation factors: membrane permeant 8-CPT-cAMP (here abbreviated cAMP), hydrocortisone, and a phosphodiesterase inhibitor, RO-20-1724 (RO). The procedure was carried out over a period of 9-11 days, and when establishing the NCC model, the astrocytes were cultured 2-8 weeks in advance. Adherence to the described procedures in the protocol has allowed the establishment of endothelial layers with highly restricted paracellular permeability, with the NCC model showing an average transendothelial electrical resistance (TEER) of 1249 ± 80 Ω cm 2 , and paracellular permeability (Papp) for Lucifer Yellow of 0.90 10 -6 ± 0.13 10 -6 cm sec -1 (mean ± SEM, n=55). Further evaluation of this pBEC phenotype showed good expression of the tight junctional proteins claudin 5, ZO-1, occludin and adherens junction protein p120 catenin. The model presented can be used for a range of studies of the BBB in health and disease and, with the highly restrictive paracellular permeability, this model is suitable for studies of transport and intracellular trafficking.
Wells, Shannon R; Jennings, Merilyn H; Rome, Courtney; Hadjivassiliou, Vicky; Papas, Konstantinos A; Alexander, Jonathon S
2010-07-01
Vitamin E, a micronutrient (comprising alpha-, beta-, gamma- and delta-tocopherols, alpha-, beta-, gamma- and delta-tocotrienols), has documented antioxidant and non-antioxidant effects, some of which inhibit inflammation and angiogenesis. We compared the abilities of alpha-, gamma- and delta-tocopherols to regulate human blood cytotoxicity (BEC) and lymphatic endothelial cytotoxicity (LEC), proliferation, invasiveness, permeability, capillary formation and suppression of TNF-alpha-induced VCAM-1 as in vitro models of inflammatory angiogenesis. alpha-, gamma- and delta-tocopherols were not toxic to either cell type up to 40 microM. In BEC, confluent cell density was decreased by all concentrations of delta- and gamma-tocopherol (10-40 microM) but not by alpha-tocopherol. LEC showed no change in cell density in response to tocopherols. delta-Tocopherol (40 microM), but not other isomers, decreased BEC invasiveness. In LEC, all doses of gamma-tocopherol, as well as the highest dose of alpha-tocopherol (40 microM), decreased cell invasiveness. delta-Tocopherol had no effect on LEC invasiveness at any molarity. delta-Tocopherol dose dependently increased cell permeability at 48 h in BEC and LEC; alpha- and gamma-tocopherols showed slight effects. Capillary tube formation was decreased by high dose (40 microM) concentrations of alpha-, gamma- and delta-tocopherol, but showed no effects with smaller doses (10-20 microM) in BEC. gamma-Tocopherol (10-20 microM) and alpha-tocopherol (10 microM), but not delta-tocopherol, increased LEC capillary tube formation. Lastly, in BEC, alpha-, gamma- and delta-tocopherol each dose-dependently reduced TNF-alpha-induced expression of VCAM-1. In LEC, there was no significant change to TNF-alpha-induced VCAM-1 expression with any concentration of alpha-, gamma- or delta-tocopherol. These data demonstrate that physiological levels (0-40 microM) of alpha-, gamma- and delta-tocopherols are nontoxic and dietary tocopherols, especially delta-tocopherol, can limit several BEC and LEC endothelial behaviors associated with angiogenesis. Tocopherols may therefore represent important nutrient-signals that limit cell behaviors related to inflammation/angiogenesis, which when deficient, may predispose individuals to risks associated with elevated angiogenesis such as inflammation and cancer; further differences seen from the tocopherols may be due to their blood or lymphatic cell origin. (c) 2010 Elsevier Inc. All rights reserved.
Guertin, Sophie; Lemieux, Karine-Sylvie; Makhoulian, Natalie; Michaud, Sébastien; Patry, Rose-Marie; Côté, Anne-Andrée; Gagnon, Fabien; Ayotte, Pierre; Bolduc, Stéphane
2011-01-01
Résumé Objectifs : La majorité des études effectuées au cours des dernières décennies ont mis en évidence une augmentation du nombre de cas de cryptorchidie et d’hypospadias entre 1970 et 1990. De plus, l’importante variabilité géographique de ces anomalies est bien décrite. Cette étude vise à mesurer la prévalence à la naissance de la cryptorchidie et de l’hypospadias au Québec, à vérifier si ces anomalies sont en augmentation et à en évaluer la répartition interrégionale. Méthode : Une étude épidémiologique descriptive a été réalisée à partir du nombre de garçons de cinq ans et moins hospitalisés pour une cryptorchidie ou un hypospadias au Québec de 1989 à 2004 selon les données du fichier administratif d’hospitalisation MED-ÉCHO. Les données sur les naissances provenaient de l’Institut de la statistique du Québec. Résultats : La prévalence annuelle moyenne pour 1000 naissances vivantes de sexe masculin est de 19,1 (IC à 95 % : 18,8–19,4) pour la cryptorchidie et 11,4 (IC à 95 % 11,1–11,6) pour l’hypospadias au Québec. Au cours de la période étudiée, la prévalence de cryptorchidie a légèrement diminué, alors que celle de l’hypospadias est demeurée stable. Comparativement à la province du Québec, des régions présentent une prévalence significativement différente de cryptorchidie et/ou d’hypospadias. . Conclusion : Au Québec, la prévalence de cryptorchidie est en légère diminution alors que celle de l’hypospadias est stable. Des variations régionales significatives sont observables. D’autres études sont nécessaires afin d’évaluer l’hypothèse d’un lien avec les contaminants environnementaux en émergence. L’implantation d’un système de surveillance des anomalies congénitales permettrait une représentation plus valide de la situation. PMID:21672476
Guertin, Sophie; Lemieux, Karine-Sylvie; Makhoulian, Natalie; Michaud, Sébastien; Patry, Rose-Marie; Côté, Anne-Andrée; Gagnon, Fabien; Ayotte, Pierre; Bolduc, Stéphane
2011-06-01
RéSUMé: : La majorité des études effectuées au cours des dernières décennies ont mis en évidence une augmentation du nombre de cas de cryptorchidie et d'hypospadias entre 1970 et 1990. De plus, l'importante variabilité géographique de ces anomalies est bien décrite. Cette étude vise à mesurer la prévalence à la naissance de la cryptorchidie et de l'hypospadias au Québec, à vérifier si ces anomalies sont en augmentation et à en évaluer la répartition interrégionale. MéTHODE :: Une étude épidémiologique descriptive a été réalisée à partir du nombre de garçons de cinq ans et moins hospitalisés pour une cryptorchidie ou un hypospadias au Québec de 1989 à 2004 selon les données du fichier administratif d'hospitalisation MED-ÉCHO. Les données sur les naissances provenaient de l'Institut de la statistique du Québec. RéSULTATS :: La prévalence annuelle moyenne pour 1000 naissances vivantes de sexe masculin est de 19,1 (IC à 95 % : 18,8-19,4) pour la cryptorchidie et 11,4 (IC à 95 % 11,1-11,6) pour l'hypospadias au Québec. Au cours de la période étudiée, la prévalence de cryptorchidie a légèrement diminué, alors que celle de l'hypospadias est demeurée stable. Comparativement à la province du Québec, des régions présentent une prévalence significativement différente de cryptorchidie et/ou d'hypospadias. . : Au Québec, la prévalence de cryptorchidie est en légère diminution alors que celle de l'hypospadias est stable. Des variations régionales significatives sont observables. D'autres études sont nécessaires afin d'évaluer l'hypothèse d'un lien avec les contaminants environnementaux en émergence. L'implantation d'un système de surveillance des anomalies congénitales permettrait une représentation plus valide de la situation.
Jacob, Steve; Ouvrard, Laurence; Bélanger, Jean-François
2011-05-01
Participatory evaluation has been developing over the last several years, particularly in the social sector. Concurrently, research on the effects of evaluation has evolved significantly. Recently, one type of result has been the object of particular attention: the effects and lessons directly attributable to the evaluative process, or process use. Analyses generally underline the direct link between participatory approaches and this type of result. However, few empirical studies testing this concept are available. Our analysis aims to enrich evaluative research on this theme and is founded on a case study of a participatory evaluation project on practices carried out in a social services organization (Centre Jeunesse de Québec--Institut universitaire [Québec Youth Centre--University Institute, Canada]). The results of our analysis show that the evaluative process favours participant learning and has had several direct and indirect effects on the practices of the involved clinical teams. The results also demonstrate the existence of a link between the intensity of actor participation (individuals, groups) and process use. Both constraining factors and factors favourable to participation and the development of the evaluative process are identified, and avenues for improvement are suggested to accentuate the effects of process use. Copyright © 2010 Elsevier Ltd. All rights reserved.
Gamifying quantum research: harnessing human intuition
NASA Astrophysics Data System (ADS)
Sherson, Jacob
In the emerging field of citizen science ordinary citizens have already contributed to research in as diverse fields as astronomy, protein and RNA folding, and neuron mapping by playing online games. In the www.scienceathome.org project, we have extended this democratized research to the realm of quantum physics by gamifying a class of challenges related to optimization of gate operations in a quantum computer. The games have been played by more than 150,000 players and perhaps surprisingly we observe that a large fraction of the players outperform state-of-the-art optimization algorithms. With a palette of additional games within cognitive science, behavioral economics, and corporate innovation we investigate the general features of individual and collaborative problem solving to shed additional light on the process of human intuition and innovation and potentially develop novel models of artificial intelligence. We have also developed and tested in classrooms educational games within classical and quantum physics and mathematics at high-school and university level. The games provide individualized learning and enhance motivation for the core curriculum by actively creating links to modern research challenges, see eg. Finally, we have recently launched our new democratic lab: an easily accessible remote interface for our ultra-cold atoms experiment allowing amateur scientists, students, and research institutions world-wide to perform state-of-the-art quantum experimentation. In first tests, nearly a thousand players helped optimize the production of our BEC and discovered novel efficient strategies.
Online teaching of inflammatory skin pathology by a French-speaking International University Network
2014-01-01
Introduction Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Québec, Switzerland and Ivory Coast. Method One of the first steps of the project was to build a learning module on inflammatory skin pathology for interns and residents in pathology and dermatology. A pathology resident from Québec spent 6 weeks in France and Switzerland to develop the contents and build the module on an e-learning Moodle platform under the supervision of two dermatopathologists. The learning module contains text, interactive clinical cases, tests with feedback, virtual slides, images and clinical photographs. For that module, the virtual slides are decentralized in 2 universities (Bordeaux and Paris 7). Each university is responsible of its own slide scanning, image storage and online display with virtual slide viewers. Results The module on inflammatory skin pathology includes more than 50 web pages with French original content, tests and clinical cases, links to over 45 virtual images and more than 50 microscopic and clinical photographs. The whole learning module is being revised by four dermatopathologists and two senior pathologists. It will be accessible to interns and residents in the spring of 2014. The experience and knowledge gained from that work will be transferred to the next international resident whose work will be aimed at creating lung and breast pathology learning modules. Conclusion The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting pathology education through the use of multi-media technology including whole slide imaging. PMID:25564778
Perron, Emilie; Battistella, Maxime; Vergier, Béatrice; Fiche, Maryse; Bertheau, Philippe; Têtu, Bernard
2014-01-01
Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Québec, Switzerland and Ivory Coast. One of the first steps of the project was to build a learning module on inflammatory skin pathology for interns and residents in pathology and dermatology. A pathology resident from Québec spent 6 weeks in France and Switzerland to develop the contents and build the module on an e-learning Moodle platform under the supervision of two dermatopathologists. The learning module contains text, interactive clinical cases, tests with feedback, virtual slides, images and clinical photographs. For that module, the virtual slides are decentralized in 2 universities (Bordeaux and Paris 7). Each university is responsible of its own slide scanning, image storage and online display with virtual slide viewers. The module on inflammatory skin pathology includes more than 50 web pages with French original content, tests and clinical cases, links to over 45 virtual images and more than 50 microscopic and clinical photographs. The whole learning module is being revised by four dermatopathologists and two senior pathologists. It will be accessible to interns and residents in the spring of 2014. The experience and knowledge gained from that work will be transferred to the next international resident whose work will be aimed at creating lung and breast pathology learning modules. The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting pathology education through the use of multi-media technology including whole slide imaging.
ERIC Educational Resources Information Center
Rabah, Jihan
2015-01-01
This paper investigated teachers' and educational consultants' perceptions of ICT integration in Québec English Schools, specifically with regards to the benefits and challenges of ICT integration therein. 23 teachers and educational consultants from seven different school boards participated in the focus group sessions. Results revealed higher…
[10 years of feminist intervention in Quebec: statement and perspectives].
Bourgon, M; Corbeil, C
1990-05-01
The authors start off by reviewing the origins and principal characteristics of feminist therapy as it appeared in the United States at the end of the 1960s. Following this step are analyzed the conditions for the emergence of feminist intervention in Québec and its specificity, terms commonly used by Québec practicians when describing their work among women. Emphasis is placed on the analysis of feminist intervention in institutional environments due to its remarkable development over the last few years. The article concisely presents the two main theoretical approaches that inspire the intervention, namely the socio-behavioral approach and the awareness approach. Following a brief overview of feminist intervention in Québec, the authors raise questions about its future.
NASA Astrophysics Data System (ADS)
Andy, H.; Blarquez, O.; Grondin, P.
2017-12-01
Facing the depletion of the wood resource in Québec and possible threats such as climate change, actors of the forest sector urge the need for a scientific frame to the forest management. A set of reference conditions has been developed for defining management targets that will help to keep forests within their natural range of variability according to the preindustrial period (XIX-XX centuries). Those reference conditions are based on the stands age-class distribution under a given fire regime that enable to define the percentage of old-growth forest (>100 years) to be maintained in a landscape. For the western spruce-moss domain in Québec, the fire return interval (FRI) is equal to 150 years resulting in a target of 48% of old-growth forests. Yet, this target supposes that the environment and the ecosystem processes are homogeneous for an entire bioclimatic domain of 175 000 km2. By using a Redundancy Analysis (RDA) on modern inventories data on natural and human disturbances; climate and physical variables and forest composition, we were able to distinguish 5 main zones where interactions between stands and their environment are homogeneous and where local management targets could be developed. We then used 10 published sedimentary pollens and charcoal series in order to reconstruct the holocene fire and vegetation dynamics for those zones. Vegetation deduced from the analysis of the pollen diagrams showed that the long-term vegetation dynamics are zone specific indicating that the modern forest composition is a result of the Holocene trajectories occurring within each zone. Charcoals series were statistically analyzed for past fire detection and long-term FRI reconstruction. They suggest that for the entire territory the holocene FRI range from 174 to 265 years resulting in old-growth forests percentage within 44 and 65% depending on the zone. Hence, we conclude that current management targets should be revised to fit more with local forests ecosystem variability at the landscape scale and that reference condition should be supplemented with data on the long-term fire dynamics and forest composition variability.
Measurement of gender inequality in neighbourhoods of Québec, Canada
2011-01-01
Introduction Few studies have measured gender inequality at levels lower than the country. We sought to develop neighbourhood indicators of gender inequality, and assess their ability to capture variability in gender inequality across Québec, Canada. Methods Aggregate 2001 census data for 11,564 neighbourhoods were obtained for men and women. Twelve indicators of gender inequality representing demographic/household characteristics, education, income, work/leisure, and political participation were selected. Neighbourhood-level gender inequality scores were computed for each indicator, and examined across parts of Québec (metropolitan areas, mid-sized cities, rural areas). Monte Carlo simulations were used to assess the ability of indicators to capture heterogeneity in gender inequality across neighbourhoods. Results Male-dominant neighbourhood-level gender inequality tended to be present for average employment income, labour force participation, employment rate, and employment in managerial positions. Female-dominant gender inequality tended to be present for divorce, single-headed households, and participation in unpaid housework, child and elderly care. Neighbourhood-level gender inequality tended to vary across metropolitan areas, mid-sized cities, and rural areas. Gender inequality scores also varied within these geographic areas. For example, there was greater income-related gender inequality in high than low income neighbourhoods. Monte Carlo simulations suggested that the variation in gender inequality across neighbourhoods was greater than expected with chance alone. Conclusion Neighbourhood-level gender inequality tended to be present in Québec, and varied across parts of the province. Greater awareness of and research on neighbourhood-level gender inequality may be warranted to inform gender policies in Québec and other nations. PMID:22087586
Measurement of gender inequality in neighbourhoods of Québec, Canada.
Tamambang, Lum; Auger, Nathalie; Lo, Ernest; Raynault, Marie-France
2011-11-16
Few studies have measured gender inequality at levels lower than the country. We sought to develop neighbourhood indicators of gender inequality, and assess their ability to capture variability in gender inequality across Québec, Canada. Aggregate 2001 census data for 11,564 neighbourhoods were obtained for men and women. Twelve indicators of gender inequality representing demographic/household characteristics, education, income, work/leisure, and political participation were selected. Neighbourhood-level gender inequality scores were computed for each indicator, and examined across parts of Québec (metropolitan areas, mid-sized cities, rural areas). Monte Carlo simulations were used to assess the ability of indicators to capture heterogeneity in gender inequality across neighbourhoods. Male-dominant neighbourhood-level gender inequality tended to be present for average employment income, labour force participation, employment rate, and employment in managerial positions. Female-dominant gender inequality tended to be present for divorce, single-headed households, and participation in unpaid housework, child and elderly care. Neighbourhood-level gender inequality tended to vary across metropolitan areas, mid-sized cities, and rural areas. Gender inequality scores also varied within these geographic areas. For example, there was greater income-related gender inequality in high than low income neighbourhoods. Monte Carlo simulations suggested that the variation in gender inequality across neighbourhoods was greater than expected with chance alone. Neighbourhood-level gender inequality tended to be present in Québec, and varied across parts of the province. Greater awareness of and research on neighbourhood-level gender inequality may be warranted to inform gender policies in Québec and other nations.
ERIC Educational Resources Information Center
April, Daniel; Bouchamma, Yamina
2017-01-01
In the province of Québec, Canada, school principals are obligated by law to ensure pedagogical supervision. This law, the Public Education Act (Government of Québec, 2017), also advocates a contractual Results-Based Management approach (RBM). We examined how the practices and perceptions of these supervisors influence the implementation of this…
The Professional Stance of Ethics and Religious Culture Teachers in Québec
ERIC Educational Resources Information Center
Estivalèzes, Mireille
2017-01-01
In September 2008, a new Ethics and Religious Culture programme was implemented in Québec's elementary and secondary schools. One of the main pedagogical challenges of this new course has been the requirement that teachers adopt a professional stance of impartiality. Teachers must refrain from sharing their points of view, so as not to influence…
ERIC Educational Resources Information Center
Aydin, Abdullah
2013-01-01
This study aims to identify constructivist learner roles in acquisitions in the secondary education chemistry curriculum of the province of Québec/Canada. This research used document analysis as a qualitative research method. According to our findings; the "learner roles" in curriculum correspond with the "student roles"…
NASA Astrophysics Data System (ADS)
Sakhel, Roger R.; Sakhel, Asaad R.; Ghassib, Humam B.; Balaz, Antun
2016-03-01
We investigate numerically conditions for order and chaos in the dynamics of an interacting Bose-Einstein condensate (BEC) confined by an external trap cut off by a hard-wall box potential. The BEC is stirred by a laser to induce excitations manifesting as irregular spatial and energy oscillations of the trapped cloud. Adding laser stirring to the external trap results in an effective time-varying trapping frequency in connection with the dynamically changing combined external+laser potential trap. The resulting dynamics are analyzed by plotting their trajectories in coordinate phase space and in energy space. The Lyapunov exponents are computed to confirm the existence of chaos in the latter space. Quantum effects and trap anharmonicity are demonstrated to generate chaos in energy space, thus confirming its presence and implicating either quantum effects or trap anharmonicity as its generator. The presence of chaos in energy space does not necessarily translate into chaos in coordinate space. In general, a dynamic trapping frequency is found to promote chaos in a trapped BEC. An apparent means to suppress chaos in a trapped BEC is achieved by increasing the characteristic scale of the external trap with respect to the condensate size.
Riel, Jessica; Major, Marie-Eve
2017-11-01
In partnership with the largest teachers' union confederation in Québec ( Centrale des syndicats du Québec), two qualitative research studies that integrate gender were conducted in the teaching community. These ergonomic studies advocated a participatory approach involving interviews and observations with high school teachers (thirty-five) and female teachers responsible for vocational training in trades with predominantly male clientele (twelve). The results revealed that gender influences work success by reducing the operational leeway available for female teachers to carry out their work and protect their health. In both studies, it was difficult to discuss these results with the teachers, especially with female teachers. Resistance, even denial, was present among high school teachers, while, in vocational training, resignation and a feeling of helplessness were observed. These reactions demonstrate that taking gender into account in prevention poses particular challenges that need to be addressed in order to promote equality between women and men in workplaces.
Vortex based information storage in Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Dutton, Zachary; Ruostekoski, Janne
2004-05-01
Recent demonstrations of coherent optical storage in atomic clouds [1,2] have opened up new possibilities for both classical and quantum information storage. In parallel, there have been advances in the generation of Laguerre-Gaussian (LG) modes with angular momentum (optical vortices)[3] and applications of these modes to quantum information architectures based on a alphabets larger than the traditional two-state systems. Here we theoretically consider the storage of such LG modes in atomic Rb-87 Bose-Einstein condensates (BECs). An LG mode writes its vortex phase pattern into a two-component BEC vortex state. The angular momentum information can then be stored in the BEC and then efficiently read back onto the optical field by switching a control field on. We study the fidelity of the writing, storage, and read-out processes. We also consider applying this method to to the transfer of more complicated states, such as two-component vortex lattices, between two spatially distinct BECs. 1. C. Liu, Z. Dutton, C.H. Behroozi, and L.V. Hau, Nature 409, 490 (2001). 2. D.F. Phillips, A. Fleischhauer, A. Mair, R.L. Walsworth, and M.D. Lukin, Phys. Rev. Lett. 86, 783 (2001). 3. A. Vaziri, Gregor Weihs, and A. Zeilinger, cond-mat/0111033.
Particle scattering by harmonically trapped Bose and Fermi gases
NASA Astrophysics Data System (ADS)
Bhattacharya, Ankita; Das, Samir; Biswas, Shyamal
2018-04-01
We have analytically explored the quantum phenomenon of particle scattering by harmonically trapped Bose and Fermi gases with the short ranged Fermi–Huang {δ }p3 interactions (Fermi 1936 Ric. Sci. 7 13; Huang and Yang 1957 Phys. Rev. 105 767) interactions among the incident particle and the scatterers. We have predicted differential scattering cross-sections and their temperature dependence in this regard. Coherent scattering even by a single boson or fermion in the finite geometry gives rise to new tool of determining energy eigenstate of the scatterer. Our predictions on the differential scattering cross-sections can be tested within the present day experimental setups, specially, for (i) 3D harmonically trapped interacting Bose–Einstein condensate (BEC), (ii) BECs in a double well, and (iii) BECs in an optical lattice.
Multicomponent Electron-Hole Superfluidity and the BCS-BEC Crossover in Double Bilayer Graphene
NASA Astrophysics Data System (ADS)
Conti, S.; Perali, A.; Peeters, F. M.; Neilson, D.
2017-12-01
Superfluidity in coupled electron-hole sheets of bilayer graphene is predicted here to be multicomponent because of the conduction and valence bands. We investigate the superfluid crossover properties as functions of the tunable carrier densities and the tunable energy band gap Eg. For small band gaps there is a significant boost in the two superfluid gaps, but the interaction-driven excitations from the valence to the conduction band can weaken the superfluidity, even blocking the system from entering the Bose-Einstein condensate (BEC) regime at low densities. At a given larger density, a band gap Eg˜80 - 120 meV can carry the system into the strong-pairing multiband BCS-BEC crossover regime, the optimal range for realization of high-Tc superfluidity.
Cham, B E; Daunter, B; Evans, R A
1991-09-01
A cream formulation containing high concentrations (10%) of a standard mixture of solasodine glycosides (BEC) has been shown to be effective in the treatment of malignant and benign human skin tumours. We now report that a preparation (Curaderm) which contains very low concentrations of BEC (0.005%) is effective in the treatment of keratoses, basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin of humans. In an open study, clinical and histological observations indicated that all lesions (56 keratoses, 39 BCCs and 29 SCCs) treated with Curaderm had regressed. A placebo formulation had no effect on a smaller number of treated lesions. Curaderm had no adverse effect on the liver, kidneys or haematopoietic system.
NASA Astrophysics Data System (ADS)
Guo, Yujin; Zeng, Xiaoyu; Zhou, Huan-Song
2018-01-01
We consider a nonlinear Schrödinger system arising in a two-component Bose-Einstein condensate (BEC) with attractive intraspecies interactions and repulsive interspecies interactions in R2. We get ground states of this system by solving a constrained minimization problem. For some kinds of trapping potentials, we prove that the minimization problem has a minimizer if and only if the attractive interaction strength ai (i = 1 , 2) of each component of the BEC system is strictly less than a threshold a*. Furthermore, as (a1 ,a2) ↗ (a* ,a*), the asymptotical behavior for the minimizers of the minimization problem is discussed. Our results show that each component of the BEC system concentrates at a global minimum of the associated trapping potential.
A Summary of Image Understanding Research at the University of Massachusetts.
1983-10-01
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Magnon Bose-Einstein condensation and spin superfluidity.
Bunkov, Yuriy M; Volovik, Grigory E
2010-04-28
Bose-Einstein condensation (BEC) is a quantum phenomenon of formation of a collective quantum state in which a macroscopic number of particles occupy the lowest energy state and thus is governed by a single wavefunction. Here we highlight the BEC in a magnetic subsystem--the BEC of magnons, elementary magnetic excitations. The magnon BEC is manifested as the spontaneously emerging state of the precessing spins, in which all spins precess with the same frequency and phase even in an inhomogeneous magnetic field. The coherent spin precession was observed first in superfluid (3)He-B and this domain was called the homogeneously precessing domain (HPD). The main feature of the HPD is the induction decay signal, which ranges over many orders of magnitude longer than is prescribed by the inhomogeneity of magnetic field. This means that spins precess not with a local Larmor frequency, but coherently with a common frequency and phase. This BEC can also be created and stabilized by continuous NMR pumping. In this case the NMR frequency plays the role of a magnon chemical potential, which determines the density of the magnon condensate. The interference between two condensates has also been demonstrated. It was shown that HPD exhibits all the properties of spin superfluidity. The main property is the existence of a spin supercurrent. This spin supercurrent flows separately from the mass current. Transfer of magnetization by the spin supercurrent by a distance of more than 1 cm has been observed. Also related phenomena have been observed: the spin current Josephson effect; the phase-slip processes at the critical current; and the spin current vortex--a topological defect which is the analog of a quantized vortex in superfluids and of an Abrikosov vortex in superconductors; and so on. It is important to mention that the spin supercurrent is a magnetic phenomenon, which is not directly related to the mass superfluidity of (3)He: it is the consequence of a specific antiferromagnetic ordering in superfluid (3)He. Several different states of coherent precession have been observed in (3)He-B: the homogeneously precessing domain (HPD); a persistent signal formed by Q-balls at very low temperatures; coherent precession with fractional magnetization; and two new modes of coherent precession in compressed aerogel. In compressed aerogel the coherent precession has been also found in (3)He-A. We demonstrate that the coherent precession of magnetization is a true BEC of magnons, with the magnon interaction term in the Gross-Pitaevskii equation being provided by spin-orbit coupling which is different for different states of the magnon BEC.
ERIC Educational Resources Information Center
Lefrançois, David; Ethier, Marc-André; Cambron-Prémont, Amélie
2017-01-01
Purpose: The Québec Ministry of Education has introduced--as of September 2017--a new mandatory course focusing on financial literacy and addressing such issues as credit scores, loans, taxes and budgets. This announcement has created intense educational debate on the "raison d'être" and content of the course. This article will summarise…
Fleet, Richard; Poitras, Julien; Archambault, Patrick; Tounkara, Fatoumata Korika; Chauny, Jean-Marc; Ouimet, Mathieu; Gauthier, Josée; Dupuis, Gilles; Tanguay, Alain; Lévesque, Jean-Frédéric; Simard-Racine, Geneviève; Haggerty, Jeannie; Légaré, France
2015-12-23
Rural emergency departments (EDs) constitute crucial safety nets for the 20% of Canadians who live in rural areas. Pilot data suggests that the province of Québec appears to provide more comprehensive access to services than do other provinces. A difference that may be attributable to provincial policy/guidelines "the provincial ED management Guide". The aim of this study was to provide a detailed description of rural EDs in Québec and utilization of the provincial ED management Guide. We selected EDs offering 24/7 medical coverage, with hospitalization beds, located in rural or small towns. We collected data via telephone, paper, and online surveys with rural ED/hospital staff. Data were also collected from Québec's Ministry of Health databases and from Statistics Canada. We computed descriptive statistics, ANOVA and t-tests were used to examine the relationship between ED census, services and inter-facility transfer requirements. A total of 23 of Québec's 26 rural EDs (88%) consented to participate in the study. The mean annual ED visits was 18 813 (Standard Deviation = 6 151). Thirty one percent of ED physicians were recent graduates with fewer than 5 years of experience. Only 6 % had residency training or certification in emergency medicine. Teams have good local access (24/7) to diagnostic equipment such as CT scanner (74%), intensive unit care (78%) and general surgical services (78%), but limited access to other consultants. Sixty one percent of participants have reported good knowledge of the provincial ED management Guide, but only 23% of them have used the guidelines. Furthermore, more than 40% of EDs were more than 300 km from levels 1 to 2 trauma centers, and only 30% had air transport access. Rural EDs in Québec are staffed by relatively new graduates working as solo physicians in well-resourced and moderately busy (by rural standards) EDs. The provincial ED management Guide may have contributed to this model of service attribution. However, the majority of rural ED staff report limited knowledge or use of the provincial ED management Guide and increased efforts at disseminating this Guide are warranted.
Roudnicky, Filip; Dieterich, Lothar C; Poyet, Cedric; Buser, Lorenz; Wild, Peter; Tang, Dave; Camenzind, Peter; Ho, Chien Hsien; Otto, Vivianne I; Detmar, Michael
2017-06-01
Bladder cancer is a frequently recurring disease with a very poor prognosis once progressed to invasive stages, and tumour-associated blood vessels play a crucial role in this process. In order to identify novel biomarkers associated with progression, we isolated blood vascular endothelial cells (BECs) from human invasive bladder cancers and matched normal bladder tissue, and found that tumour-associated BECs greatly up-regulated the expression of insulin receptor (INSR). High expression of INSR on BECs of invasive bladder cancers was significantly associated with shorter progression-free and overall survival. Furthermore, increased expression of the INSR ligand IGF-2 in invasive bladder cancers was associated with reduced overall survival. INSR may therefore represent a novel biomarker to predict cancer progression. Mechanistically, we observed pronounced hypoxia in human bladder cancer tissue, and found a positive correlation between the expression of the hypoxia marker gene GLUT1 and vascular INSR expression, indicating that hypoxia drives INSR expression in tumour-associated blood vessels. In line with this, exposure of cultured BECs and human bladder cancer cell lines to hypoxia led to increased expression of INSR and IGF-2, respectively, and IGF-2 increased BEC migration through the activation of INSR in vitro. Taken together, we identified vascular INSR expression as a potential biomarker for progression in bladder cancer. Furthermore, our data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Isse, Kumiko; Lesniak, Andrew; Grama, Kedar; Maier, John; Specht, Susan; Castillo-Rama, Marcela; Lunz, John; Roysam, Badrinath; Michalopoulos, George; Demetris, Anthony J.
2012-01-01
Routine light microscopy identifies two distinct epithelial cell populations in normal human livers: hepatocytes and biliary epithelial cells (BEC). Considerable epithelial diversity, however, arises during disease states when a variety of hepatocyte-BEC hybrid cells appear. This has been attributed to activation and differentiation of putative hepatic progenitor cells (HPC) residing in the Canals of Hering and/or metaplasia of pre-existing mature epithelial cells. A novel analytic approach consisting of multiplex labeling, high resolution whole slide imaging (WSI), and automated image analysis was used to determine if more complex epithelial cell phenotypes pre-existed in normal adult human livers, which might provide an alternative explanation for disease-induced epithelial diversity. “Virtually digested” WSI enabled quantitative cytometric analyses of individual cells displayed in a variety of formats (e.g. scatter plots) while still tethered to the WSI and tissue structure. We employed biomarkers specifically-associated with mature epithelial forms (HNF4α for hepatocytes, CK19 and HNF1β for BEC) and explored for the presence of cells with hybrid biomarker phenotypes. Results showed abundant hybrid cells in portal bile duct BEC, canals of Hering, and immediate periportal hepatocytes. These bi-potential cells likely serve as a reservoir for the epithelial diversity of ductular reactions, appearance of hepatocytes in bile ducts, and the rapid and fluid transition of BEC to hepatocytes, and vice versa. Conclusion Novel imaging and computational tools enable increased information extraction from tissue samples and quantify the considerable pre-existent hybrid epithelial diversity in normal human liver. This computationally-enabled tissue analysis approach offers much broader potential beyond the results presented here. PMID:23150208
Hybrid Optical-Magnetic Traps for Studies of 2D Quantum Turbulence in Bose-Einstein Condensates
NASA Astrophysics Data System (ADS)
Myers, Jessica Ann
Turbulence appears in most natural and man-made flows. However, the analysis of turbulence is particularly difficult. Links between microscopic fluid dynamics and statistical signatures of turbulence appear unobtainable from the postulates of fluid dynamics making turbulence one of the most important unsolved theoretical problems in physics. Two-dimensional quantum turbulence (2DQT), an emerging field of study, involves turbulence in two-dimensional (2D) flows in superfluids, such as Bose-Einstein condensates (BECs). In 2D superfluids, a turbulent state can be characterized by a disordered distribution of numerous vortex cores. The question of how to effectively and efficiently generate turbulent states in superfluids is a fundamental question in the field of quantum turbulence. Therefore, experimental studies of vortex nucleation and the onset of turbulence in a superfluid are important for achieving a deeper understanding of the overall problem of turbulence. My PhD dissertation involves the study of vortex nucleation and the onset of turbulence in quasi-2D BECs. First, I discuss experimental apparatus advancements that now enable BECs to be created in a hybrid optical-magnetic trap, an atom trapping configuration conducive to 2DQT experiments. Next, I discuss the design and construction of a quantum vortex microscope and initial vortex detection tests. Finally, I present the first experiments aimed at studying 2DQT carried out in the updated apparatus. Thermal counterflow in superfluid helium, in which the normal and superfluid components flow in opposite directions, is known to create turbulence in the superfluid. However, this phenomenon has not been simulated or studied in dilute-gas BECs as a possible vortex nucleation method. In this dissertation, I present preliminary data from the first experiments aimed at understanding thermal counterflow turbulence in dilute-gas BECs.
Matson, Liana M; Grahame, Nicholas J
2013-11-01
Multiple lines of high alcohol-preferring (HAP) mice were selectively bred for their intake of 10% ethanol (v/v) during 24-hour daily access over a 4-week period, with the highest drinking lines exhibiting intakes in excess of 20 g/kg/day. We observed circadian drinking patterns and resulting blood ethanol concentrations (BECs) in the HAP lines. We also compared the drinking rhythms and corresponding BECs of the highest drinking HAP lines to those of the C57BL/6J (B6) inbred strain. Adult male and female crossed HAP (cHAP), HAP replicate lines 1, 2, 3 and B6 mice had free-choice access to 10% ethanol and water for 3 weeks prior to bi-hourly assessments of intake throughout the dark portion of the light-dark cycle. All HAP lines reached and maintained a rate of alcohol intake above the rate at which HAP1 mice metabolize alcohol, and BECs were consistent with this finding. Further, cHAP and HAP1 mice maintained an excessive level of intake throughout the dark portion of the cycle, accumulating mean BEC levels of 261.5 ± 18.09 and 217.9 ± 25.02 mg/dl, respectively. B6 mice drank comparatively modestly, and did not accumulate high BEC levels (53.63 + 8.15 mg/dl). Free-choice drinking demonstrated by the HAP1 and cHAP lines may provide a unique opportunity for modeling the excessive intake that often occurs in alcohol-dependent individuals, and allow for exploration of predisposing factors for excessive consumption, as well as the development of physiological, behavioral and toxicological outcomes following alcohol exposure. © 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.
Temperature Dependence of the Upper Critical Field in Disordered Hubbard Model with Attraction
NASA Astrophysics Data System (ADS)
Kuchinskii, E. Z.; Kuleeva, N. A.; Sadovskii, M. V.
2017-12-01
We study disorder effects upon the temperature behavior of the upper critical magnetic field in an attractive Hubbard model within the generalized DMFT+Σ approach. We consider the wide range of attraction potentials U—from the weak coupling limit, where superconductivity is described by BCS model, up to the strong coupling limit, where superconducting transition is related to Bose-Einstein condensation (BEC) of compact Cooper pairs, formed at temperatures significantly higher than superconducting transition temperature, as well as the wide range of disorder—from weak to strong, when the system is in the vicinity of Anderson transition. The growth of coupling strength leads to the rapid growth of H c2( T), especially at low temperatures. In BEC limit and in the region of BCS-BEC crossover H c2( T), dependence becomes practically linear. Disordering also leads to the general growth of H c2( T). In BCS limit of weak coupling increasing disorder lead both to the growth of the slope of the upper critical field in the vicinity of the transition point and to the increase of H c2( T) in the low temperature region. In the limit of strong disorder in the vicinity of the Anderson transition localization corrections lead to the additional growth of H c2( T) at low temperatures, so that the H c2( T) dependence becomes concave. In BCS-BEC crossover region and in BEC limit disorder only slightly influences the slope of the upper critical field close to T c . However, in the low temperature region H c2 ( T may significantly grow with disorder in the vicinity of the Anderson transition, where localization corrections notably increase H c2 ( T = 0) also making H c2( T) dependence concave.
[Prof. Włodzimierz Kuryłowicz (MD) (1910-1991)--100th anniversary of birthday].
Kurzatkowski, Wiesław; Staniszewska, Monika; Madaliński, Kazimierz; Juśkiewicz, Ewa
2010-01-01
The death of Professor Włodzimierz Kuryłowicz on February 21, 1991 at the age of 80 was a great loss that is especially felt by all those who have been involved in the research of antibiotics. He is remembered as one of pioneers of the antibiotic era. Prof. W. Kuryłowicz was born September 26, 1910 in Lvov. He received his MD from the Jan Kazimierz University in Lvov. Following posts as an Associate Professor of Microbiology at Lvov and as a research bacteriologist at the National Institute of Hygiene in Warsaw he became a Professor of Microbiology at that Institute. He was Director of the Institute from 1964 to 1980. More than 270 of this works regarded such topics as: antibiotic biogenesis and biosynthesis, numerical taxonomy of Streptomyces spp., evaluation of BCG and microbial fine structure. Prof. W. Kuryłowicz was a recipient of the National Prize Award for scientific guidance in construction of the first antibiotic industry in Poland, and the National Prize Award for the co-authorship of the monograph "Antibiotics - Origin, Nature and Properties". He was also recipient of Doctorates honoris causa of: Nicolas Copernicus Medical University in Poland; University of Oslo; University of Lille; Medical University of Debrecen, Hungary; University of Liège, Belgium; Federal University of Pernambuco, Recife, Brazil; University of Quèbec, Canada; University of Münster, Germany.
An efficient nonlinear Feshbach engine
NASA Astrophysics Data System (ADS)
Li, Jing; Fogarty, Thomás; Campbell, Steve; Chen, Xi; Busch, Thomas
2018-01-01
We investigate a thermodynamic cycle using a Bose-Einstein condensate (BEC) with nonlinear interactions as the working medium. Exploiting Feshbach resonances to change the interaction strength of the BEC allows us to produce work by expanding and compressing the gas. To ensure a large power output from this engine these strokes must be performed on a short timescale, however such non-adiabatic strokes can create irreversible work which degrades the engine’s efficiency. To combat this, we design a shortcut to adiabaticity which can achieve an adiabatic-like evolution within a finite time, therefore significantly reducing the out-of-equilibrium excitations in the BEC. We investigate the effect of the shortcut to adiabaticity on the efficiency and power output of the engine and show that the tunable nonlinearity strength, modulated by Feshbach resonances, serves as a useful tool to enhance the system’s performance.
Bai, Xiao-Dong; Zhang, Mei; Xiong, Jun; Yang, Guo-Jian; Deng, Fu-Guo
2015-11-24
We investigate the formation of discrete breathers (DBs) and the dynamics of the mixture of two-species Bose-Einstein condensates (BECs) in open boundary optical lattices using the discrete nonlinear Schrödinger equations. The results show that the coupling of intra- and interspecies interaction can lead to the existence of pure single-species DBs and symbiotic DBs (i.e., two-species DBs). Furthermore, we find that there is a selective distillation phenomenon in the dynamics of the mixture of two-species BECs. One can selectively distil one species from the mixture of two-species BECs and can even control dominant species fraction by adjusting the intra- and interspecies interaction in optical lattices. Our selective distillation mechanism may find potential application in quantum information storage and quantum information processing based on multi-species atoms.
Bai, Xiao-Dong; Zhang, Mei; Xiong, Jun; Yang, Guo-Jian; Deng, Fu-Guo
2015-01-01
We investigate the formation of discrete breathers (DBs) and the dynamics of the mixture of two-species Bose-Einstein condensates (BECs) in open boundary optical lattices using the discrete nonlinear Schrödinger equations. The results show that the coupling of intra- and interspecies interaction can lead to the existence of pure single-species DBs and symbiotic DBs (i.e., two-species DBs). Furthermore, we find that there is a selective distillation phenomenon in the dynamics of the mixture of two-species BECs. One can selectively distil one species from the mixture of two-species BECs and can even control dominant species fraction by adjusting the intra- and interspecies interaction in optical lattices. Our selective distillation mechanism may find potential application in quantum information storage and quantum information processing based on multi-species atoms. PMID:26597592
Bose-Einstein Condensation of Long-Lifetime Polaritons in Thermal Equilibrium.
Sun, Yongbao; Wen, Patrick; Yoon, Yoseob; Liu, Gangqiang; Steger, Mark; Pfeiffer, Loren N; West, Ken; Snoke, David W; Nelson, Keith A
2017-01-06
The experimental realization of Bose-Einstein condensation (BEC) with atoms and quasiparticles has triggered wide exploration of macroscopic quantum effects. Microcavity polaritons are of particular interest because quantum phenomena such as BEC and superfluidity can be observed at elevated temperatures. However, polariton lifetimes are typically too short to permit thermal equilibration. This has led to debate about whether polariton condensation is intrinsically a nonequilibrium effect. Here we report the first unambiguous observation of BEC of optically trapped polaritons in thermal equilibrium in a high-Q microcavity, evidenced by equilibrium Bose-Einstein distributions over broad ranges of polariton densities and bath temperatures. With thermal equilibrium established, we verify that polariton condensation is a phase transition with a well-defined density-temperature phase diagram. The measured phase boundary agrees well with the predictions of basic quantum gas theory.
Feedback control of an interacting Bose-Einstein condensate using phase-contrast imaging
NASA Astrophysics Data System (ADS)
Szigeti, S. S.; Hush, M. R.; Carvalho, A. R. R.; Hope, J. J.
2010-10-01
The linewidth of an atom laser is limited by density fluctuations in the Bose-Einstein condensate (BEC) from which the atom laser beam is outcoupled. In this paper we show that a stable spatial mode for an interacting BEC can be generated using a realistic control scheme that includes the effects of the measurement backaction. This model extends the feedback theory, based on a phase-contrast imaging setup, presented by Szigeti, Hush, Carvalho, and Hope [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.80.013614 80, 013614 (2009)]. In particular, it is applicable to a BEC with large interatomic interactions and solves the problem of inadequacy of the mean-field (coherent state) approximation by utilizing a fixed number state approximation. Our numerical analysis shows the control to be more effective for a condensate with a large nonlinearity.
Feedback control of an interacting Bose-Einstein condensate using phase-contrast imaging
DOE Office of Scientific and Technical Information (OSTI.GOV)
Szigeti, S. S.; Hush, M. R.; Carvalho, A. R. R.
2010-10-15
The linewidth of an atom laser is limited by density fluctuations in the Bose-Einstein condensate (BEC) from which the atom laser beam is outcoupled. In this paper we show that a stable spatial mode for an interacting BEC can be generated using a realistic control scheme that includes the effects of the measurement backaction. This model extends the feedback theory, based on a phase-contrast imaging setup, presented by Szigeti, Hush, Carvalho, and Hope [Phys. Rev. A 80, 013614 (2009)]. In particular, it is applicable to a BEC with large interatomic interactions and solves the problem of inadequacy of the mean-fieldmore » (coherent state) approximation by utilizing a fixed number state approximation. Our numerical analysis shows the control to be more effective for a condensate with a large nonlinearity.« less
Superradiance and dynamical instability in an illuminated BEC
NASA Astrophysics Data System (ADS)
Lunden, William; Amato-Grill, Jesse; Dimitrova, Ivana; Jepsen, Niklas; Ketterle, Wolfgang
2017-04-01
An elongated, trapped Bose-Einstein condensate illuminated by an off-resonant laser beam has been used as a platform to observe superradiant Rayleigh scattering for almost two decades. We now consider the case of an elongated BEC illuminated by a pair of non-interfering, off-resonant lasers, and explore the dynamics of the coupled light-matter system in the short-time regime (i.e., times on the order of the inverse of the single-photon recoil frequency). In particular, we look for signatures of a proposed dynamical instability in the coupled system which spontaneously breaks the translational symmetry of both the BEC density and the total light field's intensity profile along the long axis of the trap. We also explore the relative roles of the spontaneous light force and the dipole force in both superradiance and this dynamical instability.
Non-destructive imaging of spinor Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Samson, E.; Vinit, Anshuman; Raman, Chandra
2013-05-01
We present a non-destructive differential imaging technique that enables the observation of the spatial distribution of the magnetization in a spinor Bose-Einstein condensate (BEC) through a Faraday rotation protocol. In our procedure, we utilize a linearly polarized, far-detuned laser beam as our imaging probe, and upon interaction with the condensate, the beam's polarization direction undergoes Faraday rotation. A differential measurement of the orthogonal polarization components of the rotated beam provides a spatial map of the net magnetization density within the BEC. The non-destructive aspect of this method allows for continuous imaging of the condensate. This imaging technique will prove useful in experimental BEC studies, such as spatially resolved magnetometry using ultracold atoms, and non-destructive imaging of non-equilibrium behavior of antiferromagnetic spinor condensates. This work was supported by the DARPA QuASAR program through a grant from ARO.
Remote entanglement between a single atom and a Bose-Einstein condensate.
Lettner, M; Mücke, M; Riedl, S; Vo, C; Hahn, C; Baur, S; Bochmann, J; Ritter, S; Dürr, S; Rempe, G
2011-05-27
Entanglement between stationary systems at remote locations is a key resource for quantum networks. We report on the experimental generation of remote entanglement between a single atom inside an optical cavity and a Bose-Einstein condensate (BEC). To produce this, a single photon is created in the atom-cavity system, thereby generating atom-photon entanglement. The photon is transported to the BEC and converted into a collective excitation in the BEC, thus establishing matter-matter entanglement. After a variable delay, this entanglement is converted into photon-photon entanglement. The matter-matter entanglement lifetime of 100 μs exceeds the photon duration by 2 orders of magnitude. The total fidelity of all concatenated operations is 95%. This hybrid system opens up promising perspectives in the field of quantum information. © 2011 American Physical Society
Zika virus crosses an in vitro human blood brain barrier model.
Alimonti, Judie B; Ribecco-Lutkiewicz, Maria; Sodja, Caroline; Jezierski, Anna; Stanimirovic, Danica B; Liu, Qing; Haqqani, Arsalan S; Conlan, Wayne; Bani-Yaghoub, Mahmud
2018-05-15
Zika virus (ZIKV) is a flavivirus that is highly neurotropic causing congenital abnormalities and neurological damage to the central nervous systems (CNS). In this study, we used a human induced pluripotent stem cell (iPSC)-derived blood brain barrier (BBB) model to demonstrate that ZIKV can infect brain endothelial cells (i-BECs) without compromising the BBB barrier integrity or permeability. Although no disruption to the BBB was observed post-infection, ZIKV particles were released on the abluminal side of the BBB model and infected underlying iPSC-derived neural progenitor cells (i-NPs). AXL, a putative ZIKV cellular entry receptor, was also highly expressed in ZIKV-susceptible i-BEC and i-NPs. This iPSC-derived BBB model can help elucidate the mechanism by which ZIKV can infect BECs, cross the BBB and gain access to the CNS.
LENR BEC Clusters on and below Wires through Cavitation and Related Techniques
NASA Astrophysics Data System (ADS)
Stringham, Roger; Stringham, Julie
2011-03-01
During the last two years I have been working on BEC cluster densities deposited just under the surface of wires, using cavitation, and other techniques. If I get the concentration high enough before the clusters dissipate, in addition to cold fusion related excess heat (and other effects, including helium-4 formation) I anticipate that it may be possible to initiate transient forms of superconductivity at room temperature.
Investigation of the coupling of the momentum distribution of a BEC with its collective of modes
NASA Astrophysics Data System (ADS)
Henn, Emanuel; Tavares, Pedro; Fritsch, Amilson; Vivanco, Franklin; Telles, Gustavo; Bagnato, Vanderlei
In our group we have a strong research line on quantum turbulence and the general investigation of Bose-Einstein condensates (BEC) subjected to oscillatory excitations. Inside this research line we investigate first the behavior of the normal modes of the BEC under this excitation and observe a non-linear behavior in the amplitude of the quadrupolar mode. Also, inside this same procedure of investigation we study the momentum distribution of a BEC to understand if it is possible to extract Kolmogorov like excitation spectra which would point to a turbulent state of matter. The condensate is perturbed, and we let it evolve in-trap after which we perform standard time-of- flight absorption imaging. The momentum distribution is extracted and analyzed as a function of the in-trap free evolution time for a 2D projected cloud. We show that the momentum distribution has its features varying periodically with the same frequency as the quadrupolar mode displayed by the atomic gas hinting at a strong coupling of both. The main consequence of that one cannot be assertive about the quantitative features of the extract spectrum of momentum and we can only rely on its qualitative features. Financial Support: FAPESP, CNPq.
NASA Astrophysics Data System (ADS)
Buick, Otto; Falcon, Pat; Alexander, G.; Siegel, Edward Carl-Ludwig
2013-03-01
Einstein[Dover(03)] critical-slowing-down(CSD)[Pais, Subtle in The Lord; Life & Sci. of Albert Einstein(81)] is Siegel CyberWar denial-of-access(DOA) operations-research queuing theory/pinning/jamming/.../Read [Aikido, Aikibojitsu & Natural-Law(90)]/Aikido(!!!) phase-transition critical-phenomenon via Siegel DIGIT-Physics (Newcomb[Am.J.Math. 4,39(1881)]-{Planck[(1901)]-Einstein[(1905)])-Poincare[Calcul Probabilités(12)-p.313]-Weyl [Goett.Nachr.(14); Math.Ann.77,313 (16)]-{Bose[(24)-Einstein[(25)]-Fermi[(27)]-Dirac[(1927)]}-``Benford''[Proc.Am.Phil.Soc. 78,4,551 (38)]-Kac[Maths.Stat.-Reasoning(55)]-Raimi[Sci.Am. 221,109 (69)...]-Jech[preprint, PSU(95)]-Hill[Proc.AMS 123,3,887(95)]-Browne[NYT(8/98)]-Antonoff-Smith-Siegel[AMS Joint-Mtg.,S.-D.(02)] algebraic-inversion to yield ONLY BOSE-EINSTEIN QUANTUM-statistics (BEQS) with ZERO-digit Bose-Einstein CONDENSATION(BEC) ``INTERSECTION''-BECOME-UNION to Barabasi[PRL 876,5632(01); Rev.Mod.Phys.74,47(02)...] Network /Net/GRAPH(!!!)-physics BEC: Strutt/Rayleigh(1881)-Polya(21)-``Anderson''(58)-Siegel[J.Non-crystalline-Sol.40,453(80)
Bose-Einstein condensation in the relativistic ideal Bose gas.
Grether, M; de Llano, M; Baker, George A
2007-11-16
The Bose-Einstein condensation (BEC) critical temperature in a relativistic ideal Bose gas of identical bosons, with and without the antibosons expected to be pair-produced abundantly at sufficiently hot temperatures, is exactly calculated for all boson number densities, all boson point rest masses, and all temperatures. The Helmholtz free energy at the critical BEC temperature is lower with antibosons, thus implying that omitting antibosons always leads to the computation of a metastable state.
Chaotic vortex filaments in a Bose–Einstein condensate and in superfluid helium
NASA Astrophysics Data System (ADS)
Nemirovskii, S. K.
2018-05-01
A statement of the quantum turbulence problem in both a Bose–Einstein condensate (BEC) and superfluid helium is formulated. In superfluid helium use is made of a so-called vortex filament method, in which quantum vortices are represented by stringlike objects, i.e. vortex lines. The dynamics of the vortex lines is determined by deterministic equations of motion, supplemented by random reconnections. Unlike He II, the laws of the dynamics of quantum vortices in BEC are based on the nonlinear Schrödinger equation. This makes it possible to obtain a microscopic description of the collision of vortices, the structure of a vortex filament, etc. A comparative analysis of these complementary approaches is carried out. It is shown that there are some features that do not automatically transfer the results obtained for BEC to vortices in He II and vice versa.
Strong-Coupling Effects and Shear Viscosity in an Ultracold Fermi Gas
NASA Astrophysics Data System (ADS)
Kagamihara, D.; Ohashi, Y.
2017-06-01
We theoretically investigate the shear viscosity η , as well as the entropy density s, in the normal state of an ultracold Fermi gas. Including pairing fluctuations within the framework of a T-matrix approximation, we calculate these quantities in the Bardeen-Cooper-Schrieffer (BCS)-Bose-Einstein condensation (BEC) crossover region. We also evaluate η / s, to compare it with the lower bound of this ratio, conjectured by Kovtun, Son, and Starinets (KSS bound). In the weak-coupling BCS side, we show that the shear viscosity η is remarkably suppressed near the superfluid phase transition temperature Tc, due to the so-called pseudogap phenomenon. In the strong-coupling BEC side, we find that, within the neglect of the vertex corrections, one cannot correctly describe η . We also show that η / s decreases with increasing the interaction strength, to become very close to the KSS bound, \\hbar /4π kB, on the BEC side.
NASA Astrophysics Data System (ADS)
Wang, Lin-Xue; Dai, Chao-Qing; Wen, Lin; Liu, Tao; Jiang, Hai-Feng; Saito, Hiroki; Zhang, Shou-Gang; Zhang, Xiao-Fei
2018-06-01
We explore the effects of system parameters on the dynamics of ring dark solitons (RDSs) and vortices followed by the collapse of RDSs in a two-component Bose-Einstein condensate (BEC). The system exhibits complicated dynamical behaviors, which are quite different from those in a scalar BEC. For two shallow RDSs with equal initial depths, the dynamical trajectories of generated vortex dipoles are similar to those in a scalar BEC, but the time for vortex dipoles to perform a periodic motion is increased. In particular, there exists a critical depth, above which vortex dipoles first move along the vertical direction and then preform complicated dynamics, including their rearrangement and recombination. Finally, we consider the case of unequal initial depths and find that the number of created vortices is determined by the depth of the shallow RDS, while their initial moving direction is determined by the deeper one.
NASA Astrophysics Data System (ADS)
Xu, Donghong; Xue, Fei
2017-12-01
We theoretically study cooling of flexural modes of a mechanical oscillator by Bose-Einstein-condensate (BEC) atoms (Rb87) trapped in a magnetic trap. The mechanical oscillator with a tiny magnet attached on one of its free ends produces an oscillating magnetic field. When its oscillating frequency matches certain hyperfine Zeeman energy of Rb87 atoms, the trapped BEC atoms are coupled out of the magnetic trap by the mechanical oscillator, flying away from the trap with stolen energy from the mechanical oscillator. Thus the mode temperature of the mechanical oscillator is reduced. The mode temperature of the steady state of mechanical oscillator, measured by the mean steady-state phonon number in the flexural mode of the mechanical oscillator, is analyzed. It is found that ground state (phonon number less than 1) may be accessible with optimal parameters of the hybrid system of mechanical oscillator and trapped BEC atoms.
Singular Atom Optics with Spinor BECs
NASA Astrophysics Data System (ADS)
Schultz, Justin T.; Hansen, Azure; Bigelow, Nicholas P.
2015-05-01
We create and study singular spin textures in pseudo-spin-1/2 BECs. A series of two-photon Raman interactions allows us to not only engineer the spinor wavefunction but also perform the equivalent of atomic polarimetry on the BEC. Adapting techniques from optical polarimetry, we can image two-dimensional maps of the atomic Stokes parameters, thereby fully reconstructing the atomic wavefunction. In a spin-1/2 system, we can represent the local spin superposition with ellipses in a Cartesian basis. The patterns that emerge from the major axes of the ellipses provide fingerprints of the singularities that enable us to classify them as lemons, stars, saddles, or spirals similar to classification schemes for singularities in singular optics, condensed matter, and liquid crystals. These techniques may facilitate the study of geometric Gouy phases in matter waves as well as provide an avenue for utilizing topological structures as quantum gates.
NASA Astrophysics Data System (ADS)
Borgh, Magnus O.; Ruostekoski, Janne
2016-05-01
We demonstrate that multiple interaction-dependent defect core structures as well as dynamics of non-Abelian vortices can be realized in the biaxial nematic (BN) phase of a spin-2 atomic Bose-Einstein condensate (BEC). An experimentally simple protocol may be used to break degeneracy with the uniaxial nematic phase. We show that a discrete spin-space symmetry in the core may be reflected in a breaking of its spatial symmetry. The discrete symmetry of the BN order parameter leads to non-commuting vortex charges. We numerically simulate reconnection of non-Abelian vortices, demonstrating formation of the obligatory rung vortex. In addition to atomic BECs, non-Abelian vortices are theorized in, e.g., liquid crystals and cosmic strings. Our results suggest the BN spin-2 BEC as a prime candidate for their realization. We acknowledge financial support from the EPSRC.
Demetris, A J; III, John G Lunz; Specht, Susan; Nozaki, Isao
2006-01-01
Basic and translational wound healing research in the biliary tree lag significantly behind similar studies on the skin and gastrointestinal tract. This is at least partly attributable to lack of easy access to the biliary tract for study. But clinical relevance, more interest in biliary epithelial cell (BEC) pathophysiology, and widespread availability of BEC cultures are factors reversing this trend. In the extra-hepatic biliary tree, ineffectual wound healing, scarring and stricture development are pressing issues. In the smallest intra-hepatic bile ducts either impaired BEC proliferation or an exuberant response can contribute to liver disease. Chronic inflammation and persistent wound healing reactions in large and small bile ducts often lead to liver cancer. General concepts of wound healing as they apply to the biliary tract, importance of cellular processes dependent on IL-6/gp130/STAT3 signaling pathways, unanswered questions, and future directions are discussed. PMID:16773708
Messing, K; Seifert, A M; Escalona, E
1997-01-01
Primary school teachers in Québec suffer psychological distress, as shown by the Québec Health Survey (M. Gervais, 1993; Santè Québec, 1995). The authors applied and extended the French model (F. Guérin, A. Laville, F. Daniellou, J. Duraffourg, & A. Kerguelen, 1991) of analysis of work activity to observing classroom teaching (14 women in 10 classrooms for a total of 48 hr 24 min) to identify stressful elements. The authors observed a rapid sequence of actions, eye fixations of short duration, little physical or mental relaxation, multiple simultaneous activities, and uncomfortable temperature and humidity levels. Teachers use many strategies to teach, to create a learning environment, and to maintain attention in classrooms under adverse conditions. Examination of these strategies led to recommendations to improve relations between the teachers and their supervisors and to make the classroom an easier place to teach.
{sup 85}Rb tunable-interaction Bose-Einstein condensate machine
DOE Office of Scientific and Technical Information (OSTI.GOV)
Altin, P. A.; Robins, N. P.; Doering, D.
We describe our experimental setup for creating stable Bose-Einstein condensates (BECs) of {sup 85}Rb with tunable interparticle interactions. We use sympathetic cooling with {sup 87}Rb in two stages, initially in a tight Ioffe-Pritchard magnetic trap and subsequently in a weak, large-volume, crossed optical dipole trap, using the 155 G Feshbach resonance to manipulate the elastic and inelastic scattering properties of the {sup 85}Rb atoms. Typical {sup 85}Rb condensates contain 4x10{sup 4} atoms with a scattering length of a=+200a{sub 0}. Many aspects of the design presented here could be adapted to other dual-species BEC machines, including those involving degenerate Fermi-Bose mixtures.more » Our minimalist apparatus is well suited to experiments on dual-species and spinor Rb condensates, and has several simplifications over the {sup 85}Rb BEC machine at JILA, which we discuss at the end of this article.« less
Quasiparticle lifetime in a mixture of Bose and Fermi superfluids.
Zheng, Wei; Zhai, Hui
2014-12-31
In this Letter, we study the effect of quasiparticle interactions in a Bose-Fermi superfluid mixture. We consider the lifetime of a quasiparticle of the Bose superfluid due to its interaction with quasiparticles in the Fermi superfluid. We find that this damping rate, i.e., the inverse of the lifetime, has quite a different threshold behavior at the BCS and the BEC side of the Fermi superfluid. The damping rate is a constant near the threshold momentum in the BCS side, while it increases rapidly in the BEC side. This is because, in the BCS side, the decay process is restricted by the constraint that the fermion quasiparticle is located near the Fermi surface, while such a restriction does not exist in the BEC side where the damping process is dominated by bosonic quasiparticles of the Fermi superfluid. Our results are related to the collective mode experiment in the recently realized Bose-Fermi superfluid mixture.
Cosmology with a stiff matter era
NASA Astrophysics Data System (ADS)
Chavanis, Pierre-Henri
2015-11-01
We consider the possibility that the Universe is made of a dark fluid described by a quadratic equation of state P =K ρ2 , where ρ is the rest-mass density and K is a constant. The energy density ɛ =ρ c2+K ρ2 is the sum of two terms: a rest-mass term ρ c2 that mimics "dark matter" (P =0 ) and an internal energy term u =K ρ2=P that mimics a "stiff fluid" (P =ɛ ) in which the speed of sound is equal to the speed of light. In the early universe, the internal energy dominates and the dark fluid behaves as a stiff fluid (P ˜ɛ , ɛ ∝a-6). In the late universe, the rest-mass energy dominates and the dark fluid behaves as pressureless dark matter (P ≃0 , ɛ ∝a-3). We provide a simple analytical solution of the Friedmann equations for a universe undergoing a stiff matter era, a dark matter era, and a dark energy era due to the cosmological constant. This analytical solution generalizes the Einstein-de Sitter solution describing the dark matter era, and the Λ CDM model describing the dark matter era and the dark energy era. Historically, the possibility of a primordial stiff matter era first appeared in the cosmological model of Zel'dovich where the primordial universe is assumed to be made of a cold gas of baryons. A primordial stiff matter era also occurs in recent cosmological models where dark matter is made of relativistic self-gravitating Bose-Einstein condensates (BECs). When the internal energy of the dark fluid mimicking stiff matter is positive, the primordial universe is singular like in the standard big bang theory. It expands from an initial state with a vanishing scale factor and an infinite density. We consider the possibility that the internal energy of the dark fluid is negative (while, of course, its total energy density is positive), so that it mimics anti-stiff matter. This happens, for example, when the BECs have an attractive self-interaction with a negative scattering length. In that case, the primordial universe is nonsingular and bouncing like in loop quantum cosmology. At t =0 , the scale factor is finite and the energy density is equal to zero. The universe first has a phantom behavior where the energy density increases with the scale factor, then a normal behavior where the energy density decreases with the scale factor. For the sake of generality, we consider a cosmological constant of arbitrary sign. When the cosmological constant is positive, the Universe asymptotically reaches a de Sitter regime where the scale factor increases exponentially rapidly with time. This can account for the accelerating expansion of the Universe that we observe at present. When the cosmological constant is negative (anti-de Sitter), the evolution of the Universe is cyclic. Therefore, depending on the sign of the internal energy of the dark fluid and on the sign of the cosmological constant, we obtain analytical solutions of the Friedmann equations describing singular and nonsingular expanding, bouncing, or cyclic universes.
Statefinder analysis of the superfluid Chaplygin gas model
DOE Office of Scientific and Technical Information (OSTI.GOV)
Popov, V.A., E-mail: vladipopov@mail.ru
2011-10-01
The statefinder indices are employed to test the superfluid Chaplygin gas (SCG) model describing the dark sector of the universe. The model involves Bose-Einstein condensate (BEC) as dark energy (DE) and an excited state above it as dark matter (DM). The condensate is assumed to have a negative pressure and is embodied as an exotic fluid with the Chaplygin equation of state. Excitations forms the normal component of superfluid. The statefinder diagrams show the discrimination between the SCG scenario and other models with the Chaplygin gas and indicates a pronounced effect of the DM equation of state and an indirectmore » interaction between their two components on statefinder trajectories and a current statefinder location.« less
Statefinder analysis of the superfluid Chaplygin gas model
NASA Astrophysics Data System (ADS)
Popov, V. A.
2011-10-01
The statefinder indices are employed to test the superfluid Chaplygin gas (SCG) model describing the dark sector of the universe. The model involves Bose-Einstein condensate (BEC) as dark energy (DE) and an excited state above it as dark matter (DM). The condensate is assumed to have a negative pressure and is embodied as an exotic fluid with the Chaplygin equation of state. Excitations forms the normal component of superfluid. The statefinder diagrams show the discrimination between the SCG scenario and other models with the Chaplygin gas and indicates a pronounced effect of the DM equation of state and an indirect interaction between their two components on statefinder trajectories and a current statefinder location.
Forming impressions from English and French first names: is there an in-group effect in Québec?
Heuvelink, Christine; McKelvie, Stuart; Drumheller, Andrea
2012-02-01
Using the Name Connotation Profile, English Canadian and French Canadian university students rated their impressions of people with English or French first names. Both the English and French students formed a more favorable impression of people who had names from their own linguistic group. These results are consistent with social identity theory, according to which people define themselves in part by groups to which they belong, with the contact hypothesis, according to which people feel more positively towards those with whom they have interacted more, and perhaps with the mere exposure effect, according to which liking for an object increases with the frequency with which it is presented.
NASA Astrophysics Data System (ADS)
Braun, Marco; Chaumont, Diane
2013-04-01
Using climate model output to explore climate change impacts on hydrology requires several considerations, choices and methods in the post treatment of the datasets. In the effort of producing a comprehensive data base of climate change scenarios for over 300 watersheds in the Canadian province of Québec, a selection of state of the art procedures were applied to an ensemble comprising 87 climate simulations. The climate data ensemble is based on global climate simulations from the Coupled Model Intercomparison Project - Phase 3 (CMIP3) and regional climate simulations from the North American Regional Climate Change Assessment Program (NARCCAP) and operational simulations produced at Ouranos. Information on the response of hydrological systems to changing climate conditions can be derived by linking climate simulations with hydrological models. However, the direct use of raw climate model output variables as drivers for hydrological models is limited by issues such as spatial resolution and the calibration of hydro models with observations. Methods for downscaling and bias correcting the data are required to achieve seamless integration of climate simulations with hydro models. The effects on the results of four different approaches to data post processing were explored and compared. We present the lessons learned from building the largest data base yet for multiple stakeholders in the hydro power and water management sector in Québec putting an emphasis on the benefits and pitfalls in choosing simulations, extracting the data, performing bias corrections and documenting the results. A discussion of the sources and significance of uncertainties in the data will also be included. The climatological data base was subsequently used by the state owned hydro power company Hydro-Québec and the Centre d'expertise hydrique du Québec (CEHQ), the provincial water authority, to simulate future stream flows and analyse the impacts on hydrological indicators. While this submission focuses on the production of climatic scenarios for application in hydrology, the submission « The (cQ)2 project: assessing watershed scale hydrological changes for the province of Québec at the 2050 horizon, a collaborative framework » by Catherine Guay describes how Hydro-Québec and CEHQ put the data into use.
Li, Dan; Zhu, Lian; Liu, Yu; Yin, Zongqi; Liu, Yi; Liu, Fangjun; He, Aijuan; Feng, Shaoqing; Zhang, Yixin; Zhang, Zhiyong; Zhang, Wenjie; Liu, Wei; Cao, Yilin; Zhou, Guangdong
2017-05-01
In vivo niche plays an important role in regulating differentiation fate of stem cells. Due to lack of proper chondrogenic niche, stable cartilage regeneration of bone marrow stromal cells (BMSCs) in subcutaneous environments is always a great challenge. This study explored the feasibility that chondrocyte sheet created chondrogenic niche retained chondrogenic phenotype of BMSC engineered cartilage (BEC) in subcutaneous environments. Porcine BMSCs were seeded into biodegradable scaffolds followed by 4weeks of chondrogenic induction in vitro to form BEC, which were wrapped with chondrocyte sheets (Sheet group), acellular small intestinal submucosa (SIS, SIS group), or nothing (Blank group) respectively and then implanted subcutaneously into nude mice to trace the maintenance of chondrogenic phenotype. The results showed that all the constructs in Sheet group displayed typical cartilaginous features with abundant lacunae and cartilage specific matrices deposition. These samples became more mature with prolonged in vivo implantation, and few signs of ossification were observed at all time points except for one sample that had not been wrapped completely. Cell labeling results in Sheet group further revealed that the implanted BEC directly participated in cartilage formation. Samples in both SIS and Blank groups mainly showed ossified tissue at all time points with partial fibrogenesis in a few samples. These results suggested that chondrocyte sheet could create a chondrogenic niche for retaining chondrogenic phenotype of BEC in subcutaneous environment and thus provide a novel research model for stable ectopic cartilage regeneration based on stem cells. In vivo niche plays an important role in directing differentiation fate of stem cells. Due to lack of proper chondrogenic niche, stable cartilage regeneration of bone marrow stromal cells (BMSCs) in subcutaneous environments is always a great challenge. The current study demonstrated that chondrocyte sheet generated by high-density culture of chondrocytes in vitro could cearte a chondrogenic niche in subcutaneous environment and efficiently retain the chondrogenic phenotype of in vitro BMSC engineered cartilage (vitro-BEC). Furthermore, cell tracing results revealed that the regenerated cartilage mainly derived from the implanted vitro-BEC. The current study not only proposes a novel research model for microenvironment simulation but also provides a useful strategy for stable ectopic cartilage regeneration of stem cells. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
A half-century analysis of landscape dynamics in southern Québec, Canada.
Jobin, Benoît; Latendresse, Claudie; Baril, Alain; Maisonneuve, Charles; Boutin, Céline; Côté, Dominique
2014-04-01
We studied landscape dynamics for three time periods (<1950, 1965, and 1997) along a gradient of agricultural intensity from highly intensive agriculture to forested areas in southern Québec. Air photos were analyzed to obtain long-term information on land cover (crop and habitat types) and linear habitats (hedgerows and riparian habitats) and landscape metrics were calculated to quantify changes in habitat configuration. Anthropogenic areas increased in all types of landscapes but mostly occurred in the highly disturbed cash crop dominated landscape. Perennial crops (pasture and hayfields) were largely converted into annual crops (corn and soybean) between 1965 and 1997. The coalescence of annual crop fields resulted in a more homogeneous agricultural landscape. Old fields and forest cover was consistently low and forest fragmentation remained stable through time in the intensive agriculture landscapes. However, forest cover increased and forest fragmentation receded in the forest-dominated landscapes following farm abandonment and the transition of old fields into forests. Tree-dominated hedgerows and riparian habitats increased in areas with intensive agriculture. Observed changes in land cover classes are related to proximate factors, such as surficial deposits and topography. Agriculture intensification occurred in areas highly suitable for agriculture whereas farm abandonment was observed in poor-quality agriculture terrains. Large-scale conversion of perennial crops into annual crops along with continued urbanization exerts strong pressures on residual natural habitats and their inhabiting wildlife. The afforestation process occurring in the more forested landscapes along with the addition of tree-dominated hedgerows and riparian habitats in the agriculture-dominated landscapes should improve landscape ecological value.
Onsager vortex formation in two-component Bose–Einstein condensates in two-dimensional traps
NASA Astrophysics Data System (ADS)
Han, Junsik; Tsubota, Makoto
2018-03-01
We study numerically the dynamics of quantized vortices in two-dimensional one-component and two-component Bose–Einstein condensates (BECs) trapped by a harmonic and box potentials. In two-component miscible BECs, we confirmed the tendency of the formation of Onsager vortices in both traps. The vortices in one component separate spatially from those in the other component, which comes from their intercomponent-coupling. We also discuss the decay of the number of vortices.
Kozak, Gosia K; Pearl, David L; Parkman, Julia; Reid-Smith, Richard J; Deckert, Anne; Boerlin, Patrick
2009-09-01
Sulfonamide-resistant Escherichia coli and Salmonella isolates from pigs and chickens in Ontario and Québec were screened for sul1, sul2, and sul3 by PCR. Each sul gene was distributed differently across populations, with a significant difference between distribution in commensal E. coli and Salmonella isolates and sul3 restricted mainly to porcine E. coli isolates.
Kozak, Gosia K.; Pearl, David L.; Parkman, Julia; Reid-Smith, Richard J.; Deckert, Anne; Boerlin, Patrick
2009-01-01
Sulfonamide-resistant Escherichia coli and Salmonella isolates from pigs and chickens in Ontario and Québec were screened for sul1, sul2, and sul3 by PCR. Each sul gene was distributed differently across populations, with a significant difference between distribution in commensal E. coli and Salmonella isolates and sul3 restricted mainly to porcine E. coli isolates. PMID:19633109
Thermo-optically induced interactions in photon Bose-Einstein Condensates
NASA Astrophysics Data System (ADS)
Alaeian, Hadiseh; Bartels, Clara; Weitz, Martin
Bose-Einstein condensation (BEC), a new state of matter, emerges when the de Broglie wavelength of bosons becomes larger than the particle separation, leading to a macroscopic occupation of the system ground state. Followed by the first experimental demonstrations of BEC in cold atomic gases, this phase transition has been observed in other bosonic gases, as polaritons and phonons. The most recent one, photon BEC, is a promising candidate for a new generation of coherent photon sources. Due to their infancy, however, many of their properties are still unknown or only partly explored. In this talk I will present my latest results on the implications of photon interactions in photon BECs. In particular, I will investigate the effect of a thermo-optic non-linearity, leading to spatially non-local and delayed interactions. Starting from the steady state behavior, I will explore the spectrum of elementary excitations as a small perturbation. Moreover, I will discuss the resulting effective photon dispersion, manifesting various properties including possible superfluidity, as well as roton and maxon modes. The implications of physical parameters as absorption, number of photons in the condensate, and cavity trap on the dispersion will be discussed. The results of this study shed new light on the implication of interactions in photonic many-body systems. Hadiseh Alaeian acknowledges the generous support from Alexander von Humboldt Foundation.
Vortex creation during magnetic trap manipulations of spinor Bose-Einstein condensates
DOE Office of Scientific and Technical Information (OSTI.GOV)
Itin, A. P.; Space Research Institute, RAS, Moscow; Morishita, T.
2006-06-15
We investigate several mechanisms of vortex creation during splitting of a spinor Bose-Einstein condensate (BEC) in a magnetic double-well trap controlled by a pair of current carrying wires and bias magnetic fields. Our study is motivated by a recent MIT experiment on splitting BECs with a similar trap [Y. Shin et al., Phys. Rev. A 72, 021604 (2005)], where an unexpected fork-like structure appeared in the interference fringes indicating the presence of a singly quantized vortex in one of the interfering condensates. It is well known that in a spin-1 BEC in a quadrupole trap, a doubly quantized vortex ismore » topologically produced by a 'slow' reversal of bias magnetic field B{sub z}. Since in the experiment a doubly quantized vortex had never been seen, Shin et al. ruled out the topological mechanism and concentrated on the nonadiabatic mechanical mechanism for explanation of the vortex creation. We find, however, that in the magnetic trap considered both mechanisms are possible: singly quantized vortices can be formed in a spin-1 BEC topologically (for example, during the magnetic field switching-off process). We therefore provide a possible alternative explanation for the interference patterns observed in the experiment. We also present a numerical example of creation of singly quantized vortices due to 'fast' splitting; i.e., by a dynamical (nonadiabatic) mechanism.« less
Yao, Yu-Qin; Li, Ji; Han, Wei; Wang, Deng-Shan; Liu, Wu-Ming
2016-01-01
The intrinsic nonlinearity is the most remarkable characteristic of the Bose-Einstein condensates (BECs) systems. Many studies have been done on atomic BECs with time- and space- modulated nonlinearities, while there is few work considering the atomic-molecular BECs with space-modulated nonlinearities. Here, we obtain two kinds of Jacobi elliptic solutions and a family of rational solutions of the atomic-molecular BECs with trapping potential and space-modulated nonlinearity and consider the effect of three-body interaction on the localized matter wave solutions. The topological properties of the localized nonlinear matter wave for no coupling are analysed: the parity of nonlinear matter wave functions depends only on the principal quantum number n, and the numbers of the density packets for each quantum state depend on both the principal quantum number n and the secondary quantum number l. When the coupling is not zero, the localized nonlinear matter waves given by the rational function, their topological properties are independent of the principal quantum number n, only depend on the secondary quantum number l. The Raman detuning and the chemical potential can change the number and the shape of the density packets. The stability of the Jacobi elliptic solutions depends on the principal quantum number n, while the stability of the rational solutions depends on the chemical potential and Raman detuning. PMID:27403634
NASA Astrophysics Data System (ADS)
Palmer, Christopher D.; Lewis, Miles E.; Geraghty, Ciaran M.; Barbosa, Fernando; Parsons, Patrick J.
2006-08-01
A biomonitoring method for the determination of Pb, Cd, and Hg at background levels in whole blood by inductively coupled plasma-mass spectrometry is described. While this method was optimized for assessing Pb, Cd and Hg at environmental levels, it also proved suitable for assessing concentrations associated with occupational exposure. The method requires as little as 200 μl of blood that is diluted 1 + 49 for direct analysis in the inductively coupled plasma-mass spectrometer. Method performance is compared to well-established AAS methods. Initial method validation was accomplished using National Institute of Standards and Technology (NIST) Standard Reference Material 966, Toxic Metals in Bovine Blood. Method detection limits (3s) are 0.05 μg dl - 1 for Pb, 0.09 μg l - 1 for Cd; and 0.17 μg l - 1 for Hg. Repeatability ranged from 1.4% to 2.8% for Pb; 3% to 10% for Cd; and 2.6% to 8.8% for Hg. In contrast, AAS method detection limits were 1 μg dl - 1 , 0.54 μg l - 1 , and 0.6 μg l - 1 , for Pb, Cd, and Hg, respectively. Further performance assessments were conducted over a 2-year period via participation in four international External Quality Assessment Schemes (EQAS) operated specifically for toxic metals in blood. This includes schemes operated by (a) the New York State Department of Health's Wadsworth Center, Albany, NY, USA (b) L'Institut National de Santé Publique du Québec, Centre de Toxicologie du Québec, Canada, (c) Friedrich-Alexander University, Erlangen, Germany, and (d) the University of Surrey, Guildford, UK Trace Elements scheme. The EQAS data reflect analytical performance for blind samples analyzed independently by both inductively coupled plasma-mass spectrometry and AAS methods.
The Quest for World Class Universities in China: Critical Reflections
ERIC Educational Resources Information Center
Ngok, Kinglun; Guo, Weiqing
2008-01-01
Building world-class universities has become a national policy priority in China since then-President Jiang Zemin announced in May 1998 that China must have several world-class universities of international advanced level. This article aims to offer critical reflections on the policy in relation to building world-class universities in China. It…
NASA Astrophysics Data System (ADS)
Baez, Joao-Joan; Lapidaryus, Michelle; Siegel, Edward Carl-Ludwig
2013-03-01
Riemann-hypothesis physics-proof combines: Siegel-Antono®-Smith[AMS Joint Mtg.(2002)- Abs.973-03-126] digits on-average statistics HIll[Am. J. Math 123, 3, 887(1996)] logarithm-function's (1,0)- xed-point base =units =scale-invariance proven Newcomb [Am. J. Math. 4, 39(1881)]-Weyl[Goett. Nachr.(1914); Math. Ann.7, 313(1916)]-Benford[Proc. Am. Phil. Soc. 78, 4, 51(1938)]-law [Kac,Math. of Stat.-Reasoning(1955); Raimi, Sci. Am. 221, 109(1969)] algebraic-inversion to ONLY Bose-Einstein quantum-statistics(BEQS) with digit d = 0 gapFUL Bose-Einstein Condensation(BEC) insight that digits are quanta are bosons because bosons are and always were quanta are and always were digits, via Siegel-Baez category-semantics tabular list-format matrix truth-table analytics in Plato-Aristotle classic ''square-of-opposition'' : FUZZYICS =CATEGORYICS/Category-Semantics, with Goodkind Bose-Einstein Condensation (BEC) ABOVE ground-state with/and Rayleigh(cut-limit of ''short-cut method''1870)-Polya(1922)-''Anderson''(1958) localization [Doyle and Snell,Random-Walks and Electrical-Networks, MAA(1981)-p.99-100!!!] in Brillouin[Wave-Propagation in Periodic-Structures(1946) Dover(1922)]-Hubbard-Beeby[J.Phys.C(1967)] Siegel[J.Nonxline-Sol.40,453(1980)] generalized-disorder collective-boson negative-dispersion mode-softening universality-principle(G...P) first use of the ``square-of-opposition'' in physics since Plato and Aristote!!!
Bulk-edge correspondence in topological transport and pumping
NASA Astrophysics Data System (ADS)
Imura, Ken-Ichiro; Yoshimura, Yukinori; Fukui, Takahiro; Hatsugai, Yasuhiro
2018-03-01
The bulk-edge correspondence (BEC) refers to a one-to-one relation between the bulk and edge properties ubiquitous in topologically nontrivial systems. Depending on the setup, BEC manifests in different forms and govern the spectral and transport properties of topological insulators and semimetals. Although the topological pump is theoretically old, BEC in the pump has been established just recently [1] motivated by the state-of-the-art experiments using cold atoms [2, 3]. The center of mass (CM) of a system with boundaries shows a sequence of quantized jumps in the adiabatic limit associated with the edge states. Despite that the bulk is adiabatic, the edge is inevitably non-adiabatic in the experimental setup or in any numerical simulations. Still the pumped charge is quantized and carried by the bulk. Its quantization is guaranteed by a compensation between the bulk and edges. We show that in the presence of disorder the pumped charge continues to be quantized despite the appearance of non-quantized jumps.
NASA Astrophysics Data System (ADS)
Yao, Yu-Qin; Han, Wei; Li, Ji; Liu, Wu-Ming
2018-05-01
Nonlinearity is one of the most remarkable characteristics of Bose–Einstein condensates (BECs). Much work has been done on one- and two-component BECs with time- or space-modulated nonlinearities, while there is little work on spinor BECs with space–time-modulated nonlinearities. In the present paper we investigate localized nonlinear waves and dynamical stability in spinor Bose–Einstein condensates with nonlinearities dependent on time and space. We solve the three coupled Gross–Pitaevskii equations by similarity transformation and obtain two families of exact matter wave solutions in terms of Jacobi elliptic functions and the Mathieu equation. The localized states of the spinor matter wave describe the dynamics of vector breathing solitons, moving breathing solitons, quasi-breathing solitons and resonant solitons. The results show that one-order vector breathing solitons, quasi-breathing solitons, resonant solitons and the moving breathing solitons ψ ±1 are all stable, but the moving breathing soliton ψ 0 is unstable. We also present the experimental parameters to realize these phenomena in future experiments.
NASA Astrophysics Data System (ADS)
Sakhel, Asaad R.; Sakhel, Roger R.
2018-02-01
We examine the dynamics of a one-dimensional harmonically trapped Bose-Einstein condensate (BEC), induced by the addition of a dimple trap whose depth oscillates with time. For this purpose, the Lagrangian variational method (LVM) is applied to provide the required analytical equations. The goal is to provide an analytical explanation for the quasiperiodic oscillations of the BEC size at resonance, that is additional to the one given by Adhikari (J Phys B At Mol Opt Phys 36:1109, 2003). It is shown that LVM is able to reproduce instabilities in the dynamics along the same lines outlined by Lellouch et al. (Phys Rev X 7:021015, 2017). Moreover, it is found that at resonance the energy dynamics display ordered oscillations, whereas at off-resonance they tend to be chaotic. Further, by using the Poincare-Lindstedt method to solve the LVM equation of motion, the resulting solution is able to reproduce the quasiperiodic oscillations of the BEC.
Gap Solitons of Superfluid Fermi Gas in FS Optical Lattices
NASA Astrophysics Data System (ADS)
Chen, Yan; Zhang, Ke-Zhi; He, Yong-Lin; Liu, Zhen-Lai; Zhu, Liao
2018-01-01
By employing the mean-field theory and hydrodynamic scheme, we study the gap solitons of superfluid Fermi gas in Fourier-Synthesized(FS) optical lattices. By means of numerical methods and variational approximation, the atomic interaction, the chemical potential, the potential depth of the lattice and relative phase of the Fermi system are derived along the Bose-Enstein condensation(BEC)side to the Bardeen-Cooper-Schrieffer (BCS)side. It means that the condition exciting gap solitons is obtained. Moreover, we analyze the fundamental gap soltions of the superfluid Fermi gas. It is found that the relative phase α impacts greatly on the properties of fundamental gap solitons for superfluid Fermi gas. Especially, the nonlinearity interaction term g decreases with α. Add, due to Fermi pressure, curvature changes of g in the BEC limit( γ = 1, here, γ is a function of an interaction parameter) is larger than that at unitary ( γ = 2/3). Spatial distribution of gap solitons exhibit very obvious different when the system transit from the BEC side to BCS side.
ERIC Educational Resources Information Center
Rubin, Mark; Wright, Chrysalis L.
2015-01-01
The present research tested the hypotheses that (a) working-class students have fewer friends at university than middle-class students and (b) this social class difference occurs because working-class students tend to be older than middle-class students. A sample of 376 first-year undergraduate students from an Australian university completed an…
Getting Students to Read before Class: Innovation in a University in Chile
ERIC Educational Resources Information Center
McGinn, Noel F.; Schiefelbein, Ernesto
2015-01-01
Reading before class has been demonstrated to improve student learning. This article describes the installation and effectiveness of a strategy to encourage student class preparation. The strategy, called the Class-to-Class Method, has been implemented in a large private university in Chile. The university hopes that this innovation will reduce…
Maynard, Serge; Campbell, Emily; Boodhoo, Katie; Gauthier, Gail; Xenocostas, Spyridoula; Charney, Dara A.
2015-01-01
Background and Objectives: In 2007, the Québec Ministry of Health issued a policy document that specifically mandated the development of addiction treatment services including screening, brief interventions and referral (SBIR) to be delivered by primary healthcare clinics throughout Québec. The current study examined the level of implementation of SBIR one year following the end of the mandate (2007–2012). Approach: Semi-structured interviews were conducted with 45 participants from 21 primary health and social service centres throughout the province. Qualitative analysis was used to evaluate the level of success each centre had in implementing SBIR and to identify organizational measures that contributed to successful implementation. Results: The results show that Québec primary health and social service centres had limited success in their efforts to integrate SBIR into their services. A comparative analysis of the centres, categorized according to their level of implementation, revealed the presence of significant organizational- and staff-level factors, including the creation of formal action plans that were conducive to the successful implementation of SBIR in primary care. Conclusion: The findings highlight the importance of offering support and guidance, as well as a menu of specific practices that are likely to assist primary health and social services centres to implement SBIR. At the organizational level, the adoption of local action plans and formal service trajectories offers a framework that allows for horizontal and vertical integration of new practices. PMID:26742118
Maynard, Serge; Campbell, Emily; Boodhoo, Katie; Gauthier, Gail; Xenocostas, Spyridoula; Charney, Dara A; Gill, Kathryn
2015-11-01
In 2007, the Québec Ministry of Health issued a policy document that specifically mandated the development of addiction treatment services including screening, brief interventions and referral (SBIR) to be delivered by primary healthcare clinics throughout Québec. The current study examined the level of implementation of SBIR one year following the end of the mandate (2007-2012). Semi-structured interviews were conducted with 45 participants from 21 primary health and social service centres throughout the province. Qualitative analysis was used to evaluate the level of success each centre had in implementing SBIR and to identify organizational measures that contributed to successful implementation. The results show that Québec primary health and social service centres had limited success in their efforts to integrate SBIR into their services. A comparative analysis of the centres, categorized according to their level of implementation, revealed the presence of significant organizational- and staff-level factors, including the creation of formal action plans that were conducive to the successful implementation of SBIR in primary care. The findings highlight the importance of offering support and guidance, as well as a menu of specific practices that are likely to assist primary health and social services centres to implement SBIR. At the organizational level, the adoption of local action plans and formal service trajectories offers a framework that allows for horizontal and vertical integration of new practices. Copyright © 2015 Longwoods Publishing.
Kovalev, Vadim M; Tse, Wang-Kong
2017-11-22
We develop a microscopic theory for the relaxation dynamics of an optically pumped two-level system (TLS) coupled to a bath of weakly interacting Bose gas. Using Keldysh formalism and diagrammatic perturbation theory, expressions for the relaxation times of the TLS Rabi oscillations are derived when the boson bath is in the normal state and the Bose-Einstein condensate (BEC) state. We apply our general theory to consider an irradiated quantum dot coupled with a boson bath consisting of a two-dimensional dipolar exciton gas. When the bath is in the BEC regime, relaxation of the Rabi oscillations is due to both condensate and non-condensate fractions of the bath bosons for weak TLS-light coupling and pre dominantly due to the non-condensate fraction for strong TLS-light coupling. Our theory also shows that a phase transition of the bath from the normal to the BEC state strongly influences the relaxation rate of the TLS Rabi oscillations. The TLS relaxation rate is approximately independent of the pump field frequency and monotonically dependent on the field strength when the bath is in the low-temperature regime of the normal phase. Phase transition of the dipolar exciton gas leads to a non-monotonic dependence of the TLS relaxation rate on both the pump field frequency and field strength, providing a characteristic signature for the detection of BEC phase transition of the coupled dipolar exciton gas.
Amato, Russell J.; Hulin, Mary W.; Winsauer, Peter J.
2012-01-01
Dehydroepiandrosterone (DHEA), 7-keto DHEA, and several comparison drugs (ethanol, chlordiazepoxide, rauwolscine, and RO15-4513) were administered to male rats responding under a multiple schedule of food and ethanol presentation to determine their selectively for decreasing ethanol-maintained responding. DHEA and 7-keto DHEA significantly decreased both ethanol- and food-maintained responding, compared to control, while also decreasing blood ethanol concentration (BEC). Acute ethanol administration also decreased responding for both food and ethanol; however, ethanol-maintained responding was more potently decreased than food-maintained responding. BEC remained relatively stable after increasing ethanol doses. Among the other drugs tested, RO15-4513 was the most selective for decreasing ethanol-maintained responding compared to food-maintained responding, and it decreased BECs as ethanol-maintained responding decreased. The largest dose of rauwolscine significantly decreased responding for food, while not affecting ethanol-maintained responding compared to control. Low to intermediate doses of rauwolscine produced small, non-significant increases in ethanol-maintained responding and BECs. Chlordiazepoxide produced significant decreases in food-maintained responding and the dose of ethanol presented, but only at the highest dose tested. Although DHEA and 7-keto DHEA did not decrease ethanol-maintained responding as selectively as ethanol or RO15-4513 under the multiple schedule, these neurosteroids may be valuable pharmacological tools in the development of new treatments for alcohol abuse and dependence. PMID:22473025
Topological vortex formation in a Bose-Einstein condensate under gravitational field
NASA Astrophysics Data System (ADS)
Kawaguchi, Yuki; Nakahara, Mikio; Ohmi, Tetsuo
2004-10-01
Topological phase imprinting is a unique technique for vortex formation in a Bose-Einstein condensate (BEC) of an alkali-metal gas, in that it does not involve rotation: the BEC is trapped in a quadrupole field with a uniform bias field which is reversed adiabatically leading to vortex formation at the center of the magnetic trap. The scenario has been experimentally verified by Leanhardt employing Na23 atoms. Recently similar experiments have been conducted by Hirotani in which a BEC of Rb87 atoms was used. In the latter experiments the authors found that fine-tuning of the field reverse time Trev is required to achieve stable vortex formation. Otherwise, they often observed vortex fragmentation or a condensate without a vortex. It is shown in this paper that this behavior can be attributed to the heavy mass of the Rb atom. The confining potential, which depends on the eigenvalue mB of the hyperfine spin F along the magnetic field, is now shifted by the gravitational field perpendicular to the vortex line. Then the positions of two weak-field-seeking states with mB=1 and 2 deviate from each other. This effect is more prominent for BECs with a heavy atomic mass, for which the deviation is greater and, moreover, the Thomas-Fermi radius is smaller. We found, by solving the Gross-Pitaevskii equation numerically, that two condensates interact in a very complicated way leading to fragmentation of vortices, unless Trev is properly tuned.
Time-of-flight expansion of binary Bose–Einstein condensates at finite temperature
NASA Astrophysics Data System (ADS)
Lee, K. L.; Jørgensen, N. B.; Wacker, L. J.; Skou, M. G.; Skalmstang, K. T.; Arlt, J. J.; Proukakis, N. P.
2018-05-01
Ultracold quantum gases provide a unique setting for studying and understanding the properties of interacting quantum systems. Here, we investigate a multi-component system of 87Rb–39K Bose–Einstein condensates (BECs) with tunable interactions both theoretically and experimentally. Such multi-component systems can be characterized by their miscibility, where miscible components lead to a mixed ground state and immiscible components form a phase-separated state. Here we perform the first full simulation of the dynamical expansion of this system including both BECs and thermal clouds, which allows for a detailed comparison with experimental results. In particular we show that striking features emerge in time-of-flight (TOF) for BECs with strong interspecies repulsion, even for systems which were separated in situ by a large gravitational sag. An analysis of the centre of mass positions of the BECs after expansion yields qualitative agreement with the homogeneous criterion for phase-separation, but reveals no clear transition point between the mixed and the separated phases. Instead one can identify a transition region, for which the presence of a gravitational sag is found to be advantageous. Moreover, we analyse the situation where only one component is condensed and show that the density distribution of the thermal component also shows some distinct features. Our work sheds new light on the analysis of multi-component systems after TOF and will guide future experiments on the detection of miscibility in these systems.
Strategic Approach for Developing World-Class Universities in Egypt
ERIC Educational Resources Information Center
Ahmed, Hanaa Ouda Khadri
2015-01-01
In the past decade, the term "world-class university" "WCU"--also called "globally competitive universities", "world-class", "elite", or "flagship" universities--has become a catch phrase, not simply for improving the quality of learning and research in higher education but also, more…
Delorme, S.; Houde, I.; Deschênes, L.
2003-01-01
We conducted a seroepidemiologic study to determine the prevalence of anti-human herpesvirus 8 antibodies in a renal transplant population at Hôtel-Dieu de Québec Hospital. Testing for immunoglobulin G antibodies against lytic and latent antigens was performed on serum samples from 150 renal transplant patients. Human immunodeficiency virus-positive patients with confirmed Kaposi's sarcoma were used as positive controls. None of the renal transplant patients tested positive. PMID:14605164
Towards a Semantic Web of Community, Content and Interactions
2005-09-01
importance of setting goals and deadlines as a means to achieving progress on the nebulous road to a dissertation. Jim Herbsleb sparked my interest in...RDF, such as Turtle [Bec04], a text syntax for RDF, and N-Triples [GDB04]. 45 </dc:creator> <dc:title>The Semantic Web: An Introduction</dc:title...2):22–41, 1990. 2.2.2 [Bec04] Dave Beckett. Turtle –terse rdf triple language. http://www.ilrt.bris.ac.uk/discovery/2004/01/ turtle /, January 2004. 4
Canonical ensemble ground state and correlation entropy of Bose-Einstein condensate
NASA Astrophysics Data System (ADS)
Svidzinsky, Anatoly; Kim, Moochan; Agarwal, Girish; Scully, Marlan O.
2018-01-01
Constraint of a fixed total number of particles yields a correlation between the fluctuation of particles in different states in the canonical ensemble. Here we show that, below the temperature of Bose-Einstein condensation (BEC), the correlation part of the entropy of an ideal Bose gas is cancelled by the ground-state contribution. Thus, in the BEC region, the thermodynamic properties of the gas in the canonical ensemble can be described accurately in a simplified model which excludes the ground state and assumes no correlation between excited levels.
Social Class, Identity and the "Good" Student: Negotiating University Culture
ERIC Educational Resources Information Center
Pearce, Jane; Down, Barry; Moore, Elizabeth
2008-01-01
Through the use of narrative portraits this paper discusses social class and identity, as working-class university students perceive them. With government policy encouraging wider participation rates from under-represented groups of people within the university sector, working-class students have found themselves to be the objects of much…
Bacillus Calmette-Guérin (BCG) vaccination patterns in the province of Québec, Canada, 1956-1974.
Rousseau, Marie-Claude; Conus, Florence; Kâ, Khady; El-Zein, Mariam; Parent, Marie-Élise; Menzies, Dick
2017-08-24
In the province of Québec, Canada, the Bacillus Calmette-Guérin (BCG) vaccine was offered to newborns and school-age children from the 1950s to mid-1970s in an organized tuberculosis prevention program. We aimed to describe the annual rates of skin test administration, proportion of skin tests that were positive, and rates of BCG vaccination from 1956 to 1974 according to age, sex, and administrative region. For rates, numerators were extracted from the Québec BCG Vaccination Registry whereas population denominators were obtained from the Canadian Census and governmental publications. Time trends were assessed with linear regression. A total of 2,755,336 skin tests and 2,531,366 BCG vaccinations were administered. Yearly rates of skin tests, routinely administered before vaccination among all except newborns, were highest among children aged 5-9 (9.3 per 100) and 10-14years (7.9 per 100). The proportion of positive skin tests varied greatly by age, ranging from 10.2% among children <1year to 67.2% among adults ≥20years. The vast majority of individuals who had a negative skin test were subsequently vaccinated, whereas those with a positive result were not, as per recommended guidelines. The average annual vaccination rate was highest among children aged <1year (43.8 per 100) and 5-9year-olds (6.9 per 100). There were salient differences in immunization rates, including positive skin tests and vaccinations, across administrative regions but no difference by sex. This is the first comprehensive description of the tuberculosis prevention program in Québec which offered free, non-mandatory BCG vaccination. Our results confirm that the targeted groups, newborns and school-age children, were preferentially reached. Socioeconomic, demographic, and organizational factors may explain regional differences in immunization rates. Beyond presenting a historical context for this vaccination campaign, our findings are relevant to contemporary uses of the Québec BCG Vaccination Registry in epidemiological research. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
Viazis, Stelios; Akhtar, Mastura; Feirtag, Joellen; Diez-Gonzalez, Francisco
2011-02-01
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 has been recognized as a major foodborne pathogen responsible for frequent gastroenteritis outbreaks. Phages and essential oils can be used as a natural antimicrobial method to reduce bacterial pathogens from the food supply. The objective of this study was to determine the effect of a bacteriophage cocktail, BEC8, alone and in combination with the essential oil trans-cinnameldehyde (TC) on the viability of a mixture of EHEC O157:H7 strains applied on whole baby romaine lettuce and baby spinach leaves. The EHEC O157:H7 strains used were Nal(R) mutants of EK27, ATCC 43895, and 472. Exponentially growing cells from tryptic soy (TS) broth cultures were spot inoculated on leaves and dried. EHEC cells were placed at low, medium, and high inoculum levels (10(4), 10(5), and 10(6) CFU/mL, respectively). Appropriate controls, BEC8 (approx. 10(6) PFU/leaf), and TC (0.5% v/v) were applied on treated leaves. The leaves were incubated at 4, 8, 23, and 37 °C in Petri dishes with moistened filter papers. EHEC survival was determined using standard plate count on nalidixic acid (50 μg/mL) Sorbitol MacConkey agar. No survivors were detected when both leaves were treated with BEC8 or TC individually at low inoculum levels after 24 h at 23 and 37 °C. When the EHEC inoculum size increased and/or incubation temperature decreased, the efficacy of BEC8 and TC decreased. However, when the two treatments were combined, no survivors were detected after 10 min at all temperatures and inoculum levels on both leafy greens. These results indicated that the BEC8/TC combination was highly effective against EHEC on both leafy greens. This combination could potentially be used as an antimicrobial to inactivate EHEC O157:H7 and reduce their incidence in the food chain. Copyright © 2010 Elsevier Ltd. All rights reserved.
Freel, Kelle C; Charron, Guillaume; Leducq, Jean-Baptiste; Landry, Christian R; Schacherer, Joseph
2015-10-01
A thorough sampling of maple, oak, birch, and apple tree bark in North America yielded a set of isolates that represent a yeast species not yet formally described. The strains obtained were all isolated from the Canadian province of Québec. These four isolates have identical electrophoretic karyotypes, distinct from other species of the genus Lachancea, and are most closely related to the formally recognized species Lachancea thermotolerans according to the D1/D2 domain of the LSU rDNA gene and 5.8S–ITS region. Previous studies revealed the existence of a population of strains closely related to L. thermotolerans, with unique D1/D2 sequences and the ability to grow on melibiose, which is also true for these isolates. The sequences obtained here (for the D1/D2, and 5.8S–ITS region) are identical among the four strains, and in a phylogenetic analysis of the D1/D2 region, the strains form a distinct clade with the previously described population closely related to L. thermotolerans, composed of isolates from Japan, as well as from the provinces of Ontario and Québec in Canada. On the basis of select physiological and phylogenetic characteristics, a novel ascosporogenous yeast species, Lachancea quebecensis sp. nov., is proposed. The type strain LL11_022T ( = CBS 14138T = CLIB 1763T = UCDFST 15-106T) was isolated from maple tree bark in the Station Duchesnay, QC region of Québec, Canada. The MycoBank number is MB811749.
Topological vortex formation in a Bose-Einstein condensate under gravitational field
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kawaguchi, Yuki; Ohmi, Tetsuo; Nakahara, Mikio
2004-10-01
Topological phase imprinting is a unique technique for vortex formation in a Bose-Einstein condensate (BEC) of an alkali-metal gas, in that it does not involve rotation: the BEC is trapped in a quadrupole field with a uniform bias field which is reversed adiabatically leading to vortex formation at the center of the magnetic trap. The scenario has been experimentally verified by Leanhardt et al. employing {sup 23}Na atoms. Recently similar experiments have been conducted by Hirotani et al. in which a BEC of {sup 87}Rb atoms was used. In the latter experiments the authors found that fine-tuning of the fieldmore » reverse time T{sub rev} is required to achieve stable vortex formation. Otherwise, they often observed vortex fragmentation or a condensate without a vortex. It is shown in this paper that this behavior can be attributed to the heavy mass of the Rb atom. The confining potential, which depends on the eigenvalue m{sub B} of the hyperfine spin F along the magnetic field, is now shifted by the gravitational field perpendicular to the vortex line. Then the positions of two weak-field-seeking states with m{sub B}=1 and 2 deviate from each other. This effect is more prominent for BECs with a heavy atomic mass, for which the deviation is greater and, moreover, the Thomas-Fermi radius is smaller. We found, by solving the Gross-Pitaevskii equation numerically, that two condensates interact in a very complicated way leading to fragmentation of vortices, unless T{sub rev} is properly tuned.« less
NASA Astrophysics Data System (ADS)
Ghasemian, E.; Tavassoly, M. K.
2017-09-01
In this paper we consider a system consisting of a number of two-level atoms in a Bose-Einstein condensate (BEC) and a single-mode quantized field, which interact with each other in the presence of two different damping sources, i.e. cavity and atomic reservoirs. The reservoirs which we consider here are thermal and squeezed vacuum ones corresponding to field and atom modes. Strictly speaking, by considering both types of reservoirs for each of the atom and field modes, we investigate the quantum dynamics of the interacting bosons in the system. Then, via solving the quantum Langevin equations for such a dissipative BEC system, we obtain analytical expressions for the time dependence of atomic population inversion, mean atom as well as photon number and quadrature squeezing in the field and atom modes. Our investigations demonstrate that for modeling the real physical systems, considering the dissipation effects is essential. Also, numerical calculations which are presented show that the atomic population inversion, the mean number of atoms in the BEC and the photons in the cavity possess damped oscillatory behavior due to the presence of reservoirs. In addition, non-classical squeezing effects in the field quadrature can be observed especially when squeezed vacuum reservoirs are taken into account. As an outstanding property of this model, we may refer to the fact that one can extract the atom-field coupling constant from the frequency of oscillations in the mentioned quantities such as atomic population inversion.
Constraints on Bose-Einstein-condensed axion dark matter from the Hi nearby galaxy survey data
NASA Astrophysics Data System (ADS)
Li, Ming-Hua; Li, Zhi-Bing
2014-05-01
One of the leading candidates for dark matter is the axion or axionlike particle in the form of a Bose-Einstein condensate (BEC). In this paper, we present an analysis of 17 high-resolution galactic rotation curves from the Hi nearby galaxy survey (THINGS) data [F. Walter et al., Astron. J. 136, 2563 (2008)] in the context of the axionic Bose-Einstein condensed dark matter model. Assuming a repulsive two-body interaction, we solve the nonrelativistic Gross-Pitaevskii equation for N gravitationally trapped bosons in the Thomas-Fermi approximation. We obtain the maximum possible radius R and the mass profile M(r) of a dilute axionic Bose-Einstein condensed gas cloud. A standard least- χ2 method is employed to find the best-fit values of the total mass M of the axion BEC and its radius R. The local mass density of BEC axion dark matter is ρa ≃0.02 GeV /cm3, which agrees with that presented by Beck [C. Beck, Phys. Rev. Lett. 111, 231801 (2013)]. The axion mass ma we obtain depends not only on the best-fit value of R, but also on the s-wave scattering length a (ma∝a1/3). The transition temperature Ta of an axion BEC on galactic scales is also estimated. Comparing the calculated Ta with the ambient temperature of galaxies and galaxy clusters implies that a ˜10-3 fm. The corresponding axion mass is ma≃0.58 meV. We compare our results with others.
Scott, Danny W.; Paradis, Manon
1990-01-01
Dermatological disorders accounted for 18.8% and 15.2%, respectively, of all the dogs and cats examined at the Small Animal Clinic, University of Montreal, Saint-Hyacinthe, during a one-year period. In dogs, the most common groups of dermatological disorders encountered were bacterial folliculitis and furunculosis, allergic dermatitis, endocrinopathy, neoplasia, ectoparasitism, and immune-mediated dermatitis. The most common primary final diagnoses were bacterial folliculitis and furunculosis, atopy, food hypersensitivity, flea bite hypersensitivity, hyperadrenocorticism, and hypothyroidism. Breed predispositions were found for several canine dermatoses: bacterial folliculitis and furunculosis (collie, German shepherd, golden retriever, Newfoundland), atopy (boxer, golden retriever), food hypersensitivity (boxer, German shepherd), hyperadrenocorticism (miniature poodle), hypothyroidism (Doberman pinscher, Gordon setter), castration-responsive alopecia (chow chow), demodicosis (Old English sheepdog), and idiopathic pruritus (pit bull terrier). In cats, the most common dermatoses were abscesses, otodectic mange, cheyletiellosis, flea bite hypersensitivity, atopy, flea infestation, neoplasia, and food hypersensitivity. Himalayan and Persian cats accounted for 50% of the cases of cheyletiellosis and 75% of the cases of dermatophytosis, respectively. Hereditary primary seborrhea oleosa was seen only in Persian cats. PMID:17423707
Aad, G.; Abbott, B.; Abdallah, J.; ...
2015-10-01
The paper presents studies of Bose–Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range pT> 100 MeV and |η|< 2.5 in proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 μb -1, 190 μb -1 and 12.4 nb -1 for 0.9 TeV, 7 TeV minimum-bias and 7 TeV high-multiplicity data samples, respectively. The multiplicity dependence of the BEC parameters characterizing the correlation strength and the correlation source size are investigated for charged-particle multiplicities of up to 240. Amore » saturation effect in the multiplicity dependence of the correlation source size parameter is observed using the high-multiplicity 7 TeV data sample. In conclusion, the dependence of the BEC parameters on the average transverse momentum of the particle pair is also investigated.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Aad, G.; Abbott, B.; Abdallah, J.
The paper presents studies of Bose–Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range pT> 100 MeV and |η|< 2.5 in proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 μb -1, 190 μb -1 and 12.4 nb -1 for 0.9 TeV, 7 TeV minimum-bias and 7 TeV high-multiplicity data samples, respectively. The multiplicity dependence of the BEC parameters characterizing the correlation strength and the correlation source size are investigated for charged-particle multiplicities of up to 240. Amore » saturation effect in the multiplicity dependence of the correlation source size parameter is observed using the high-multiplicity 7 TeV data sample. In conclusion, the dependence of the BEC parameters on the average transverse momentum of the particle pair is also investigated.« less
Asymmetry of bifurcated features in radio pulsar profiles
NASA Astrophysics Data System (ADS)
Dyks, J.; Rudak, B.
2012-03-01
High-quality integrated radio profiles of some pulsars contain bifurcated, highly symmetric emission components (BECs). They are observed when our line of sight traverses through a split-fan shaped emission beam. It is shown that for oblique cuts through such a beam, the features appear asymmetric at nearly all frequencies, except for a single 'frequency of symmetry'νsym, at which both peaks in the BEC have the same height. Around νsym, the ratio of flux in the two peaks of a BEC evolves in a way resembling the multifrequency behaviour of J1012+5307. Because of the inherent asymmetry resulting from the oblique traverse of the sightline, each minimum in double notches can be modelled independently. Such a composed model reproduces the double notches of B1929+10 if the fitted function is the microscopic beam of curvature radiation in the orthogonal polarization mode. These results confirm our view that some of the double components in radio pulsar profiles directly reveal the microscopic nature of the emitted radiation beam as the microbeam of the curvature radiation polarized orthogonally to the trajectory of electrons.
Vida, Stephen; Durocher, Martin; Ouarda, Taha B M J; Gosselin, Pierre
2012-11-01
This study examined whether the number of emergency department visits for "mental and psychosocial problems" varies with temperature or humidity. The number of visits in three geographic areas of Québec were examined as a function of temperature and humidity by using routinely collected May-September data for 1995-2007 (N=347,552 visits). Data for two age groups (under age 65 and age 65 and older) were examined. Incidence rate ratios for mean temperature and humidity were estimated by using Poisson regression and generalized additive models. The number of visits tended to increase with increasing mean temperature. At 22.5 °C (72.5 °F) and 25 °C (77.0 °F), the number was usually significantly higher than average. Visits increased with humidity in the younger age group. Results suggest increased use of emergency departments for mental and psychosocial problems with higher mean temperature and humidity, especially in metropolitan areas and in southern Québec. Climate change may make this effect increasingly important.
Bose-Einstein Condensation and Bose Glasses in an S = 1 Organo-metallic quantum magnet
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zapf, Vivien
2012-06-01
I will speak about Bose-Einstein condensation (BEC) in quantum magnets, in particular the compound NiCl2-4SC(NH2)2. Here a magnetic field-induced quantum phase transition to XY antiferromagnetism can be mapped onto BEC of the spins. The tuning parameter for BEC transition is the magnetic field rather than the temperature. Some interesting phenomena arise, for example the fact that the mass of the bosons that condense can be strongly renormalized by quantum fluctuations. I will discuss the utility of this mapping for both understanding the nature of the quantum magnetism and testing the thermodynamic limit of Bose-Einstein Condensation. Furthermore we can dope themore » system in a clean and controlled way to create the long sought-after Bose Glass transition, which is the bosonic analogy of Anderson localization. I will present experiments and simulations showing evidence for a new scaling exponent, which finally makes contact between theory and experiments. Thus we take a small step towards the difficult problem of understanding the effect of disorder on bosonic wave functions.« less
Gauvin, Lise; Steiger, Howard
2012-08-01
We examined the population reach, acceptability, and perceived potential of an initiative that developed a promotional tool for a healthy body image, the Québec Charter for a Healthy and Diverse Body Image. The Charter, developed through consensus building by a multisectoral, government-led task force, outlined actions to be undertaken by organizations or citizens to reduce media pressures favoring thinness. Six months after the Charter's launch, we surveyed 1003 Québec residents aged 18 years or older about their knowledge of the Charter, their willingness to adhere to it, and their perceptions of its potential. After minimal prompting, more than 35% of respondents recognized the Charter. About 33.7% were very favorable toward personally adhering to the Charter and 32.7% perceived the Charter as having high potential to sensitize people to negative consequences of disordered eating. Women showed greater likelihood and people with lesser education showed lower likelihood of spontaneous recognition. An initiative involving the creation of a body image Charter reaches a substantial portion of adults and is viewed as acceptable and potentially influential.
Tunable-Range, Photon-Mediated Atomic Interactions in Multimode Cavity QED
NASA Astrophysics Data System (ADS)
Vaidya, Varun D.; Guo, Yudan; Kroeze, Ronen M.; Ballantine, Kyle E.; Kollár, Alicia J.; Keeling, Jonathan; Lev, Benjamin L.
2018-01-01
Optical cavity QED provides a platform with which to explore quantum many-body physics in driven-dissipative systems. Single-mode cavities provide strong, infinite-range photon-mediated interactions among intracavity atoms. However, these global all-to-all couplings are limiting from the perspective of exploring quantum many-body physics beyond the mean-field approximation. The present work demonstrates that local couplings can be created using multimode cavity QED. This is established through measurements of the threshold of a superradiant, self-organization phase transition versus atomic position. Specifically, we experimentally show that the interference of near-degenerate cavity modes leads to both a strong and tunable-range interaction between Bose-Einstein condensates (BECs) trapped within the cavity. We exploit the symmetry of a confocal cavity to measure the interaction between real BECs and their virtual images without unwanted contributions arising from the merger of real BECs. Atom-atom coupling may be tuned from short range to long range. This capability paves the way toward future explorations of exotic, strongly correlated systems such as quantum liquid crystals and driven-dissipative spin glasses.
Partnership as a new strategy in mental health policy: the case of Québec.
Boudreau, F
1991-01-01
The notion of partnership is increasingly adopted as a sine qua non for the successful resolution of strategic problems in the field of human services. In this paper, I examine Québec's recent mental health policy and its operational definition of the concept. I then suggest some of the roots and reasons behind this province's adoption of le partenariat as the basis for policy. I suggest that it is a response to four key strategic problems: (1) the exhaustion of resources and allocation of losses; (2) the loss of faith in government and the consequent need to redefine the role of the state; (3) the loss of faith in professional knowledge and the increasingly forceful voice of alternative and "psychiatric survivor" groups; (4) the problem of overload in pluralist and competitive democracy and, related to this, the ubiquitous search for consensus and frictionless solutions. I conclude that in adopting the language of partnership, policymakers in Québec and elsewhere are being seduced by the possibilities of neocorporatist ideas applied to the management of human services.
The second law of thermodynamics and quantum heat engines: Is the law strictly enforced?
NASA Astrophysics Data System (ADS)
Keefe, Peter D.
2010-01-01
A quantum heat engine is a construct having a working medium which is cyclically processed through a pair of control variables of state involving a Bose-Einstein condensation (BEC) in which a heat input is converted into a work output. Of interest is a first species of quantum heat engine in which the working medium is macroscopic in the sense the size scale is sufficiently large that the BEC is not volumetrically coherent. In this first species of quantum heat engine, near Carnot efficiencies may be possible. Of particular interest is a second species of quantum heat engine in which the working medium is mesoscopic in the sense that the size scale is sufficiently small that the BEC is volumetrically coherent. In this second species of quantum heat engine, the resulting in-process non-equilibrium condition affects the finally arrived at control variables of state such that Carnot efficiencies and beyond may be possible. A Type I superconductor is used to model the first and second species of quantum heat engine.
Quantum Landau damping in dipolar Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Mendonça, J. T.; Terças, H.; Gammal, A.
2018-06-01
We consider Landau damping of elementary excitations in Bose-Einstein condensates (BECs) with dipolar interactions. We discuss quantum and quasiclassical regimes of Landau damping. We use a generalized wave-kinetic description of BECs which, apart from the long-range dipolar interactions, also takes into account the quantum fluctuations and the finite-energy corrections to short-range interactions. Such a description is therefore more general than the usual mean-field approximation. The present wave-kinetic approach is well suited for the study of kinetic effects in BECs, such as those associated with Landau damping, atom trapping, and turbulent diffusion. The inclusion of quantum fluctuations and energy corrections changes the dispersion relation and the damping rates, leading to possible experimental signatures of these effects. Quantum Landau damping is described with generality, and particular examples of dipolar condensates in two and three dimensions are studied. The occurrence of roton-maxon excitations, and their relevance to Landau damping, are also considered in detail. The present approach is mainly based on a linear perturbative procedure, but the nonlinear regime of Landau damping, which includes atom trapping and atom diffusion, is also briefly discussed.
Brazil's Exception to the World-Class University Movement
ERIC Educational Resources Information Center
Alperin, Juan Pablo
2013-01-01
The continued importance of university rankings has only served to fuel the growth of the "world-class" university movement. There is a growing impression that, in a globalised and interconnected world, no country can do without a world-class university. No country, that is, except Brazil. While Brazil has the resources necessary to…
Thoughts on the Role of Government in the Development of World-Class Universities in China
ERIC Educational Resources Information Center
Guangcai, Yan
2011-01-01
Looking at the rise of world-class universities through history, creating an institutional environment in which universities are relatively autonomous, while also ensuring effective material support from the government is essential for the formation of world-class universities. It is worth examining the deteriorating academic environment in China…
Numerical simulation code for self-gravitating Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Madarassy, Enikő J. M.; Toth, Viktor T.
2013-04-01
We completed the development of simulation code that is designed to study the behavior of a conjectured dark matter galactic halo that is in the form of a Bose-Einstein Condensate (BEC). The BEC is described by the Gross-Pitaevskii equation, which can be solved numerically using the Crank-Nicholson method. The gravitational potential, in turn, is described by Poisson’s equation, that can be solved using the relaxation method. Our code combines these two methods to study the time evolution of a self-gravitating BEC. The inefficiency of the relaxation method is balanced by the fact that in subsequent time iterations, previously computed values of the gravitational field serve as very good initial estimates. The code is robust (as evidenced by its stability on coarse grids) and efficient enough to simulate the evolution of a system over the course of 109 years using a finer (100×100×100) spatial grid, in less than a day of processor time on a contemporary desktop computer. Catalogue identifier: AEOR_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEOR_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 5248 No. of bytes in distributed program, including test data, etc.: 715402 Distribution format: tar.gz Programming language: C++ or FORTRAN. Computer: PCs or workstations. Operating system: Linux or Windows. Classification: 1.5. Nature of problem: Simulation of a self-gravitating Bose-Einstein condensate by simultaneous solution of the Gross-Pitaevskii and Poisson equations in three dimensions. Solution method: The Gross-Pitaevskii equation is solved numerically using the Crank-Nicholson method; Poisson’s equation is solved using the relaxation method. The time evolution of the system is governed by the Gross-Pitaevskii equation; the solution of Poisson’s equation at each time step is used as an initial estimate for the next time step, which dramatically increases the efficiency of the relaxation method. Running time: Depends on the chosen size of the problem. On a typical personal computer, a 100×100×100 grid can be solved with a time span of 10 Gyr in approx. a day of running time.
Côté-Lussier, Carolyn; Fitzpatrick, Caroline; Séguin, Louise; Barnett, Tracie A
2015-07-01
This study applied socioecological and cumulative risk exposure frameworks to test the hypotheses that 1) the experience of poverty is associated with feeling less safe at school, and 2) feeling less safe is associated with engaging in poorer weight-related behaviors, as well as an increased probability of being overweight or obese. Data were from the ongoing Québec Longitudinal Study of Child Development, initiated in 1998 with a population-based cohort of 2,120 Québec (Canada) infants 5 months of age and their parent or primary caregiver. Measures of youths' (age, 13 years) self-reported feelings of safety, screen time, physical activity, and objectively assessed not overweight/obese (70%), overweight (22%), and obese (8%) weight status were collected in 2011. Family poverty trajectory from birth was assessed by using latent growth modeling. As hypothesized, exposure to poverty was associated with feeling less safe at school and, in turn, with an increased probability of being overweight or obese. The association was most pronounced for youths who experienced chronic poverty. Compared with youths who experienced no poverty and felt unsafe, those who experienced chronic poverty and felt unsafe were nearly 18% more likely to be obese (9.2% vs. 11.2%). Although feeling unsafe was associated with screen time, screen time did not predict weight status. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Command and Control (C2) Agility (Agilite du commandement et du controle (C2))
2014-10-01
de la rigueur et de l’emploi des méthodes de mesure et d’amélioration de l’agilité du C2. Le spectre des missions... Control and Intelligence (C2I) Section DRDC Valcartier 2459 de la Bravoure Road Québec (Québec) G3J 1X5 CANADA Email: Micheline.Belanger@drdc...Agilité du commandement et du contrôle (C2) (STO-TR-SAS-085) Synthèse L’agilité est la capacité à effectuer avec succès, s’occuper de
UHV-compatible magnetic material for atom optics
NASA Astrophysics Data System (ADS)
Hopkins, S. A.; Hinds, E. A.; Boshier, M. G.
Magnetic videotape is of great interest for trapping and guiding cold atomic vapors, but was hitherto considered unsuitable for manipulating Bose-Einstein condensates (BEC) because of the presumed evolution of gas under vacuum. We have studied the outgassing in vacuum of the most promising tape, Ampex 398 Betacam SP. We find that after cleaning in ethanol and baking for 200 h at 100 °C the magnetic patterns are undisturbed and the outgassing is remarkably small: 4×10-10 Torrls-1cm-2, due mostly to hydrogen. This makes the tape exceedingly attractive for manipulation of BEC.
Rotational fluxons of Bose-Einstein condensates in coplanar double-ring traps
DOE Office of Scientific and Technical Information (OSTI.GOV)
Brand, J.; Institute of Natural Sciences, Massey University; Haigh, T. J.
Rotational analogs to magnetic fluxons in conventional Josephson junctions are predicted to emerge in the ground state of rotating tunnel-coupled annular Bose-Einstein condensates (BECs). Such topological condensate-phase structures can be manipulated by external potentials. We determine conditions for observing macroscopic quantum tunneling of a fluxon. Rotational fluxons in double-ring BECs can be created, manipulated, and controlled by external potentials in different ways than is possible in the solid-state system, thus rendering them a promising candidate system for studying and utilizing quantum properties of collective many-particle degrees of freedom.
Sickle cell disease caused by Hb S/Québec-CHORI: treatment with hydroxyurea and response.
Tubman, Venée N; Bennett, Carolyn M; Luo, Hong-yuan; Chui, David H K; Heeney, Matthew M
2007-08-01
Sickle hemoglobin (Hb S;betaGlu 6 Val) is due to an A>T transversion in codon 6 of the beta-globin gene. Other variant hemoglobins mimic Hb A, S, or C on newborn screening and clinical laboratory diagnostic tools, thus making their correct identification potentially difficult. Sickling disorders can result in individuals who are compound heterozygous for beta-globin mutations (e.g., Hb SC, HbSO(Arab)). The authors report a second case of HbS/Québec-CHORI, a severe compound heterozygous sickling disorder and their experience managing this patient with hydroxyurea.
[The blood-brain barrier in ageing persons].
Haaning, Nina; Damsgaard, Else Marie; Moos, Torben
2018-03-26
Brain capillary endothelial cells (BECs) form the ultra-tight blood-brain barrier (BBB). The permeability of the BBB increases with increasing age and neurovascular and neurodegenerative diseases. Major defects of the BBB can be initiated by increased permeability to plasma proteins in small arteriosclerotic arteries and release of proteins from degenerating neurons into the brain extracellular space. These proteins deposit in perivascular spaces, and subsequently negatively influence the BECs leading to decreased expression of barrier proteins. Detection of BBB defects by the use of non-invasive techniques is relevant for clinical use in settings with advanced age and severe brain disorders.
Atom chip microscopy: A novel probe for strongly correlated materials
NASA Astrophysics Data System (ADS)
Kasch, Brian; Naides, Matthew; Turner, Richard; Ray, Ushnish; Lev, Benjamin
2010-03-01
Atom chip technology---substrates supporting micron-sized current-carrying wires that create magnetic microtraps near surfaces for thermal or degenerate gases of neutral atoms---will enable single-shot, large area detection of magnetic flux below the 10-7 flux quantum level. By harnessing the extreme sensitivity of Bose-Einstein condensates (BECs) to external perturbations, cryogenic atom chips could provide a magnetic flux detection capability that surpasses all other techniques by a factor of 10^2--10^3. We describe the merits of atom chip microscopy, our Rb BEC and atom chip apparatus, and prospects for imaging strongly correlated condensed matter materials.
University Students' Problem Posing Abilities and Attitudes towards Mathematics.
ERIC Educational Resources Information Center
Grundmeier, Todd A.
2002-01-01
Explores the problem posing abilities and attitudes towards mathematics of students in a university pre-calculus class and a university mathematical proof class. Reports a significant difference in numeric posing versus non-numeric posing ability in both classes. (Author/MM)
Antimicrobial use on Canadian dairy farms.
Saini, V; McClure, J T; Léger, D; Dufour, S; Sheldon, A G; Scholl, D T; Barkema, H W
2012-03-01
Antimicrobial use (AMU) data are critical for formulating policies for containing antimicrobial resistance. The present study determined AMU on Canadian dairy farms and characterized variation in AMU based on herd-level factors such as milk production, somatic cell count, herd size, geographic region and housing type. Drug use data were collected on 89 dairy herds in 4 regions of Canada, Alberta, Ontario, Québec, and the Maritime provinces (Prince Edward Island, New Brunswick, and Nova Scotia) for an average of 540 d per herd. Dairy producers and farm personnel were asked to deposit empty drug containers into specially provided receptacles. Antimicrobial use was measured as antimicrobial drug use rate (ADUR), with the unit being number of animal defined-daily doses (ADD)/1,000 cow-days. Antimicrobial drug use rates were determined at farm, region, and national level. Combined ADUR of all antimicrobial classes was 14.35 ADD/1,000 cow-days nationally. National level ADUR of the 6 most commonly used antimicrobial drug classes, cephalosporins, penicillins, penicillin combinations, tetracyclines, trimethoprim-sulfonamide combinations, and lincosamides were 3.05, 2.56, 2.20, 1.83, 0.87, and 0.84 ADD/1,000 cow-days, respectively. Dairy herds in Ontario were higher users of third-generation cephalosporins (ceftiofur) than in Québec. Alberta dairy herds were higher users of tetracyclines in comparison to Maritimes. Antimicrobial drug use rate was higher via systemic route as compared with intramammary and other routes of administration (topical, oral, and intrauterine). The ADUR of antimicrobials used intramammarily was higher for clinical mastitis treatment than dry cow therapy. For dry cow therapy, penicillin ADUR was greater than ADUR of first-generation cephalosporins. For clinical mastitis treatment, ADUR of intramammary penicillin combinations was greater than ADUR of cephapirin. Herd-level milk production was positively associated with overall ADUR, ADUR of systemically administered ceftiofur, cephapirin administered for dry cow therapy, and pirlimycin administered for clinical mastitis treatment. Herd size and ADUR of systemically administered ceftiofur were also positively associated. In conclusion, β-lactams were most commonly used on Canadian dairy farms. Among antimicrobials of very high importance in human medicine, the use of fluoroquinolones was rare, whereas third-generation cephalosporins and penicillin combinations containing colistin were used very frequently on Canadian dairy farms. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
Time and Money Explain Social Class Differences in Students' Social Integration at University
ERIC Educational Resources Information Center
Rubin, Mark; Wright, Chrysalis L.
2017-01-01
Working-class students tend to be less socially integrated at university than middle-class students. The present research investigated two potential reasons for this working-class social exclusion effect. First, working-class students may have fewer finances available to participate in social activities. Second, working-class students tend to be…
Hong, Gyong Hwa; Kwon, Hyouk-Soo; Moon, Keun-Ai; Park, So Young; Park, Sunjoo; Lee, Kyoung Young; Ha, Eun Hee; Kim, Tae-Bum; Moon, Hee-Bom; Lee, Heung Kyu; Cho, You Sook
2016-03-01
Recruitment and activation of dendritic cells (DCs) in the lungs are critical for Th2 responses in asthma, and CCL20 secreted from bronchial epithelial cells (BECs) is known to influence the recruitment of DCs. Because asthma is a disease that is closely associated with oxidative stress, we hypothesized that clusterin, an oxidative stress regulatory molecule, may have a role in the development of allergic airway inflammation. The aim of this study was to examine whether clusterin regulates CCL20 production from the BECs and the subsequent DC recruitment in the lungs. To verify the idea, clusterin knockout (Clu(-/-)), clusterin heterogeneous (Clu(+/-)), and wild-type mice were exposed intranasally to house dust mite (HDM) extract to induce allergic airway inflammation. We found that the total number of immune cells in bronchoalveolar lavage fluid and the lung was increased in Clu(-/-) and Clu(+/-) mice. Of these immune cells, inflammatory DCs (CD11b(+)CD11c(+)) and Ly6C(high) monocyte populations in the lung were significantly increased, which was accompanied by increased levels of various chemokines, including CCL20 in bronchoalveolar lavage fluid, and increased oxidative stress markers in the lung. Moreover, HDM-stimulated human BECs with either up- or downregulated clusterin expression showed that CCL20 secretion was negatively associated with clusterin expression. Interestingly, clusterin also reduced the level of intracellular reactive oxygen species, which is related to induction of CCL20 expression after HDM stimulation. Thus, the antioxidant property of clusterin is suggested to regulate the expression of CCL20 in BECs and the subsequent recruitment of inflammatory DCs in the airway. Copyright © 2016 by The American Association of Immunologists, Inc.
Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activation.
Romberger, Debra J; Heires, Art J; Nordgren, Tara M; Souder, Chelsea P; West, William; Liu, Xiang-de; Poole, Jill A; Toews, Myron L; Wyatt, Todd A
2015-08-15
Workers exposed to aerosolized dust present in concentrated animal feeding operations (CAFOs) are susceptible to inflammatory lung diseases, such as chronic obstructive pulmonary disease. Extracts of dust collected from hog CAFOs [hog dust extract (HDE)] are potent stimulators of lung inflammatory responses in several model systems. The observation that HDE contains active proteases prompted the present study, which evaluated the role of CAFO dust proteases in lung inflammatory processes and tested whether protease-activated receptors (PARs) are involved in the signaling pathway for these events. We hypothesized that the damaging proinflammatory effect of HDE is due, in part, to the proteolytic activation of PARs, and inhibiting the proteases in HDE or disrupting PAR activation would attenuate HDE-mediated inflammatory indexes in bronchial epithelial cells (BECs), in mouse lung slices in vitro, and in a murine in vivo exposure model. Human BECs and mouse lung slice cultures stimulated with 5% HDE released significantly more of each of the cytokines measured (IL-6, IL-8, TNF-α, keratinocyte-derived chemokine/CXC chemokine ligand 1, and macrophage inflammatory protein-2/CXC chemokine ligand 2) than controls, and these effects were markedly diminished by protease inhibition. Inhibition of PARs also blunted the HDE-induced cytokine release from BECs. In addition, protease depletion inhibited HDE-induced BEC intracellular PKCα and PKCε activation. C57BL/6J mice administered 12.5% HDE intranasally, either once or daily for 3 wk, exhibited increased total cellular and neutrophil influx, bronchial alveolar fluid inflammatory cytokines, lung histopathology, and inflammatory scores compared with mice receiving protease-depleted HDE. These data suggest that proteases in dust from CAFOs are important mediators of lung inflammation, and these proteases and their receptors may provide novel targets for therapeutic intervention in CAFO dust-induced airways disease.
Cecconi, Elva; Incerti, Guido; Capozzi, Fiore; Adamo, Paola; Bargagli, Roberto; Benesperi, Renato; Candotto Carniel, Fabio; Favero-Longo, Sergio Enrico; Giordano, Simonetta; Puntillo, Domenico; Ravera, Sonia; Spagnuolo, Valeria; Tretiach, Mauro
2018-05-01
In biomonitoring, the knowledge of background element content (BEC) values is an essential pre-requisite for the correct assessment of pollution levels. Here, we estimated the BEC values of a highly performing biomonitor, the epiphytic lichen Pseudevernia furfuracea, by means of a careful review of literature data, integrated by an extensive field survey. Methodologically homogeneous element content datasets, reflecting different exposure conditions across European and extra-European countries, were compiled and comparatively analysed. Element content in samples collected in remote areas was compared to that of potentially enriched samples, testing differences between medians for 25 elements. This analysis confirmed that the former samples were substantially unaffected by anthropogenic contributions, and their metrics were therefore proposed as a first overview at supra-national background level. We also showed that bioaccumulation studies suffer a huge methodological variability. Limited to original field data, we investigated the background variability of 43 elements in 62 remote Italian sites, characterized in GIS environment for anthropization, land use, climate and lithology at different scale resolution. The relationships between selected environmental descriptors and BEC were tested using Principal Component Regression (PCR) modelling. Elemental composition resulted significantly dependent on land use, climate and lithology. In the case of lithogenic elements, regression models correctly reproduced the lichen content throughout the country at randomly selected sites. Further descriptors should be identified only for As, Co, and V. Through a multivariate approach we also identified three geographically homogeneous macro-regions for which specific BECs were provided for use as reference in biomonitoring applications. Copyright © 2017 Elsevier B.V. All rights reserved.
Wang, Xiaohua; Zhao, Hua; Shi, Lei; Xu, Fangsen
2014-01-01
Low boron (B) seriously limits the growth of oilseed rape (Brassica napus L.), a high B demand species that is sensitive to low B conditions. Significant genotypic variations in response to B deficiency have been observed among B. napus cultivars. To reveal the genetic basis for B efficiency in B. napus, quantitative trait loci (QTLs) for the plant growth traits, B uptake traits and the B efficiency coefficient (BEC) were analyzed using a doubled haploid (DH) population derived from a cross between a B-efficient parent, Qingyou 10, and a B-inefficient parent, Westar 10. A high-density genetic map was constructed based on single nucleotide polymorphisms (SNPs) assayed using Brassica 60 K Infinium BeadChip Array, simple sequence repeats (SSRs) and amplified fragment length polymorphisms (AFLPs). The linkage map covered a total length of 2139.5 cM, with 19 linkage groups (LGs) and an average distance of 1.6 cM between adjacent markers. Based on hydroponic evaluation of six B efficiency traits measured in three separate repeated trials, a total of 52 QTLs were identified, accounting for 6.14–46.27% of the phenotypic variation. A major QTL for BEC, qBEC-A3a, was co-located on A3 with other QTLs for plant growth and B uptake traits under low B stress. Using a subset of substitution lines, qBEC-A3a was validated and narrowed down to the interval between CNU384 and BnGMS436. The results of this study provide a novel major locus located on A3 for B efficiency in B. napus that will be suitable for fine mapping and marker-assisted selection breeding for B efficiency in B. napus. PMID:25375356
Matifat, E; Perreault, K; Gagné, M; Léveillé, M; Desmeules, F
2018-06-01
To improve the efficiency of the health care system, new interprofessional models of care are emerging. In 2015, two provincial professional colleges, regulating the practice of physiotherapists and that of pharmacists in the province of Québec, Canada, developed a new interprofessional model of care. This model is designed to guide non-prescription medication recommendations by physiotherapists treating patients in primary care with neuromusculoskeletal disorders (NMSKD) with the collaboration of pharmacists. To assess Québec physiotherapists' interests to use this model and explore their opinions concerning their ability to recommend non-prescription medications to patients in primary care with NMSKD. An email invitation to complete an electronic survey was sent in February 2016 to all the Ordre professionnel de la physiothérapie du Québec's registered physiotherapists. The survey included a questionnaire with 31 questions divided into 5 sections. Descriptive analyses and Chi-square tests (χ 2 ) were performed to compare proportions (%) across demographic and clinical characteristics. Two hundred twenty-five physiotherapists completed the full survey. Of these, 70% of respondents knew of the model of care, but only 15% had previously used it. Perceived workload increase was one major reason reported for this lack of use (51%). Most of the respondents had a positive perception of this model and interactions with pharmacists and were confident regarding their ability to safely recommend medication (63%). However, 63% believed that further training was necessary to enable physiotherapists to provide efficient and safe non-prescription medication recommendations to patients with NMSKD. Overall, physiotherapists have a positive perception of this model, but there remain opportunities for increased integration into practice. Most respondents believe that additional training is required regarding non-prescription medication recommendations. © 2018 John Wiley & Sons, Ltd.
Superfluid transition temperature in a trapped gas of Fermi atoms with a Feshbach resonance
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ohashi, Y.; Institute of Physics, University of Tsukuba, Ibaraki 305; Griffin, A.
2003-03-01
We investigate strong-coupling effects on the superfluid phase transition in a gas of Fermi atoms with a Feshbach resonance. The Feshbach resonance describes a composite quasiboson that can give rise to an additional pairing interaction between the Fermi atoms. This attractive interaction becomes stronger as the threshold energy 2{nu} of the Feshbach resonance two-particle bound state is lowered. In a recent paper, we showed that in the uniform Fermi gas, this tunable pairing interaction naturally leads to a crossover from a BCS state to a Bose-Einstein condensate (BEC) of the Nozieres and Schmitt-Rink kind, in which the BCS-type superfluid phasemore » transition continuously changes into the BEC type as the threshold energy is decreased. In this paper, we extend our previous work by including the effect of a harmonic trap potential, treated within the local-density approximation. We also give results for both weak and strong coupling to the Feshbach resonance. We show that the BCS-BEC crossover phenomenon strongly modifies the shape of the atomic density profile at the superfluid phase-transition temperature T{sub c}, reflecting the change of the dominant particles going from Fermi atoms to composite bosons. In the BEC regime, these composite bosons are shown to first appear well above T{sub c}. We also discuss the 'phase diagram' above T{sub c} as a function of the tunable threshold energy 2{nu}. We introduce a characteristic temperature T*(2{nu}) describing the effective crossover in the normal phase from a Fermi gas of atoms to a gas of stable molecules.« less
Mondal, Nandan Kumar; Ghosh, Sreenita; Ray, Manas Ranjan
2011-04-03
Genotoxicity of glue sniffing/huffing and tobacco use has been examined in 302 street boys (median age 13 years) and 50 age-matched control school boys who were neither tobacco nor glue users. All the street boys were tobacco users. In addition, 155 were addicted to gasp an industrial adhesive popularly known as 'Golden glue'. Micronucleus (MN) frequency was determined as a measure of chromosomal breakage in exfoliated buccal epithelial cells (BECs) and DNA double strand breaks were quantitatively assessed by counting γ-H2AX foci using immunofluorescence microscopy. Micronucleated cell frequencies (MCFs) in BEC of glue non-addicted (only tobacco) and addicted (tobacco plus glue) street boys were 1.87 ± 1.06‰ and 4.04 ± 2.55‰ respectively, which were significantly higher than that of control (0.32 ± 0.11‰, p<0.0001). Similarly, the numbers γ-H2AX foci in nuclei of BEC were 2.3- and 5.2-times more than control in glue non-addicted and addicted street boys respectively (p<0.0001). Spearman's rank correlation revealed a strong positive association between years of glue addiction with MCFs and γ-H2AX foci numbers, and the association between glue addiction and chromosomal and DNA damage remained positive and significant after controlling income, spending on addiction and loss of appetite as potential confounders in multivariate logistic regression analysis. Thus, addiction to tobacco among the street children in India is associated with chromosomal and DNA damage in BECs and the severity of these changes is significantly increased by the habit of sniffing/huffing of industrial glue. Copyright © 2011 Elsevier B.V. All rights reserved.
The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium.
Fu, Xiao Wen; Rekow, Stephen S; Spindel, Eliot R
2012-10-15
Our laboratory has previously reported that bronchial epithelial cells (BEC) express a regulatory cascade of classic neurotransmitters and receptors that communicate in an almost neuronal-like manner to achieve physiological regulation. In this paper we show that the similarity between neurotransmitter signaling in neurons and BEC extends to the level of transmitter receptor allosteric modulators. Lynx1 is a member of the ly-6/three-finger superfamily of proteins, many of which modulate receptor signaling activity. Lynx1 specifically has been shown to modulate nicotinic acetylcholine receptor (nAChR) function in neurons by altering receptor sensitivity and desensitization. We now report that lynx1 forms a complex with α7 nAChR in BEC and serves to negatively regulate α7 downstream signaling events. Treatment of primary cultures of BEC with nicotine increased levels of nAChR subunits and that increase was potentiated by lynx1 knockdown. Lynx1 knockdown also potentiated the nicotine-induced increase in GABA(A) receptors (GABA(A)R) and MUC5AC mRNA expression, and that effect was blocked by α7 antagonists and α7 knockdown. In parallel with the increases in nAChR, GABA(A)R, and mucin mRNA levels, lynx1 knockdown also increased levels of p-Src. Consistent with this, inhibition of Src signaling blocked the ability of the lynx1 knockdown to increase basal and nicotine-stimulated GABA(A)R and mucin mRNA expression. Thus lynx1 appears to act as a negative modulator of α7 nAChR-induced events by inhibiting Src activation. This suggests that lynx1 agonists or mimetics are a potentially important therapeutic target to develop new therapies for smoking-related diseases characterized by increased mucin expression.
ERIC Educational Resources Information Center
Thomsen, Jens Peter; Munk, Martin D.; Eiberg-Madsen, Misja; Hansen, Gro Inge
2013-01-01
This article studies the educational strategies adopted by university students from different class backgrounds in a Scandinavian welfare regime. Studies show distinct differences among classes relating to economic considerations, risk-averse behavior, and patterns of socialization among university students. We investigate these differences…
Supreme Court rules on disability discrimination.
Elliott, R
2000-01-01
On 3 May 2000, the Supreme Court of Canada released a unanimous decision involving the interpretation of the term "handicap" in Québec's anti-discrimination legislation in three complaints filed with the province's human rights commission. While none of the cases involved HIV-related discrimination, the Court's strong decision is of definite benefit in protecting and promoting the rights of people with HIV/AIDS, particularly for those living in Québec. The decision recognizes that people are protected against discrimination based on disability even if their condition does not give rise to any functional limitation and the discrimination is based on the perception that they are disabled.
Unconventional field induced phases in a quantum magnet formed by free radical tetramers
NASA Astrophysics Data System (ADS)
Saúl, Andrés; Gauthier, Nicolas; Askari, Reza Moosavi; Côté, Michel; Maris, Thierry; Reber, Christian; Lannes, Anthony; Luneau, Dominique; Nicklas, Michael; Law, Joseph M.; Green, Elizabeth Lauren; Wosnitza, Jochen; Bianchi, Andrea Daniele; Feiguin, Adrian
2018-02-01
We report experimental and theoretical studies on the magnetic and thermodynamic properties of NIT-2Py, a free radical based organic magnet. From magnetization and specific-heat measurements we establish the temperature versus magnetic field phase diagram which includes two Bose-Einstein condensates (BEC) and an infrequent half-magnetization plateau. Calculations based on density functional theory demonstrate that magnetically this system can be mapped to a quasi-two-dimensional structure of weakly coupled tetramers. Density matrix renormalization group calculations show the unusual characteristics of the BECs where the spins forming the low-field condensate are different than those participating in the high-field one.
Investigations of quantum pendulum dynamics in a spin-1 BEC
NASA Astrophysics Data System (ADS)
Hoang, Thai; Gerving, Corey; Land, Ben; Anquez, Martin; Hamley, Chris; Chapman, Michael
2013-05-01
We investigate the quantum spin dynamics of a spin-1 BEC initialized to an unstable critical point of the dynamical phase space. The subsequent evolution of the collective states of the system is analogous to an inverted simple pendulum in the quantum limit and yields non-classical states with quantum correlations. For short evolution times in the low depletion limit, we observe squeezed states and for longer times beyond the low depletion limit we observe highly non-Gaussian distributions. C.D. Hamley, C.S. Gerving, T.M. Hoang, E.M. Bookjans, and M.S. Chapman, ``Spin-Nematic Squeezed Vacuum in a Quantum Gas,'' Nature Physics 8, 305-308 (2012).
NASA Astrophysics Data System (ADS)
Rouhani, Hassan; Leconte, Robert
2018-06-01
Climate change will affect precipitation and flood regimes. It is anticipated that the Probable Maximum Precipitation (PMP) and Probable Maximum Flood (PMF) will be modified in a changing climate. This paper aims to quantify and analyze climate change influences on PMP and PMF in three watersheds with different climatic conditions across the province of Québec, Canada. Output data from the Canadian Regional Climate Model (CRCM) was used to estimate PMP and Probable Maximum Snow Accumulation (PMSA) in future climate projections, which was then used to force the SWAT hydrological model to estimate PMF. PMP and PMF values were estimated for two time horizons each spanning 30 years: 1961-1990 (recent past) and 2041-2070 (future). PMP and PMF were separately analyzed for two seasons: summer-fall and spring. Results show that PMF in the watershed located in southern Québec would remain unchanged in the future horizon, but the trend for the watersheds located in the northeastern and northern areas of the province is an increase of up to 11%.
He, Aijuan; Liu, Lina; Luo, Xusong; Liu, Yu; Liu, Yi; Liu, Fangjun; Wang, Xiaoyun; Zhang, Zhiyong; Zhang, Wenjie; Liu, Wei; Cao, Yilin; Zhou, Guangdong
2017-01-13
Functional reconstruction of large osteochondral defects is always a major challenge in articular surgery. Some studies have reported the feasibility of repairing articular osteochondral defects using bone marrow stromal cells (BMSCs) and biodegradable scaffolds. However, no significant breakthroughs have been achieved in clinical translation due to the instability of in vivo cartilage regeneration based on direct cell-scaffold construct implantation. To overcome the disadvantages of direct cell-scaffold construct implantation, the current study proposed an in vitro cartilage regeneration strategy, providing relatively mature cartilage-like tissue with superior mechanical properties. Our strategy involved in vitro cartilage engineering, repair of osteochondral defects, and evaluation of in vivo repair efficacy. The results demonstrated that BMSC engineered cartilage in vitro (BEC-vitro) presented a time-depended maturation process. The implantation of BEC-vitro alone could successfully realize tissue-specific repair of osteochondral defects with both cartilage and subchondral bone. Furthermore, the maturity level of BEC-vitro had significant influence on the repaired results. These results indicated that in vitro cartilage regeneration using BMSCs is a promising strategy for functional reconstruction of osteochondral defect, thus promoting the clinical translation of cartilage regeneration techniques incorporating BMSCs.
Scaling up the precision in a ytterbium Bose-Einstein condensate interferometer
NASA Astrophysics Data System (ADS)
McAlpine, Katherine; Plotkin-Swing, Benjamin; Gochnauer, Daniel; Saxberg, Brendan; Gupta, Subhadeep
2016-05-01
We report on progress toward a high-precision ytterbium (Yb) Bose-Einstein condensate (BEC) interferometer, with the goal of measuring h/m and thus the fine structure constant α. Here h is Planck's constant and m is the mass of a Yb atom. The use of the non-magnetic Yb atom makes our experiment insensitive to magnetic field noise. Our chosen symmetric 3-path interferometer geometry suppresses errors from vibration, rotation, and acceleration. The precision scales with the phase accrued due to the kinetic energy difference between the interferometer arms, resulting in a quadratic sensitivity to the momentum difference. We are installing and testing the laser pulses for large momentum transfer via Bloch oscillations. We will report on Yb BEC production in a new apparatus and progress toward realizing the atom optical elements for high precision measurements. We will also discuss approaches to mitigate two important systematics: (i) atom interaction effects can be suppressed by creating the BEC in a dynamically shaped optical trap to reduce the density; (ii) diffraction phase effects from the various atom-optical elements can be accounted for through an analysis of the light-atom interaction for each pulse.
Transport in a capacitive ultracold atomtronic circuit
NASA Astrophysics Data System (ADS)
Eller, Benjamin; Warren, Kayla; Eckel, Stephen; Clark, Charles; Edwards, Mark
2016-05-01
A recent NIST experiment studied the transport of a gaseous Bose-Einstein condensate (BEC) confined in an atomtronic ``dumbbell'' circuit. The optically created condensate potential consisted of a tight harmonic potential in the vertical direction confining the BEC to a horizontial plane. The horizontal potential consisted of two cylindrical wells separated by a channel produced by a harmonic oscillator potential transverse to the line joining the wells. The BEC, formed in the ``source'' well, was released to flow toward the ``drain'' well. We modeled this system with the Gross-Pitaevskii (GP) equation and found good agreement with the data provided that the channel potential is carefully reproduced. The GP simulations show behavior, not detectable in the experiment, that atoms can jump out of the dumbbell area after filling up the drain well. We describe the GP evolution of this system with a model RCL circuit having a time-dependent resistance. This resistance exhibits a strong connection to the time-dependence of the atom loss in the drain. We also studied and present the dependence of the R and L parameters of this model circuit on the channel shape. Supported by NSF Grant PHY-1413768 and ARO Atomtronics MURI.
Steiger, Howard
2012-01-01
Objectives. We examined the population reach, acceptability, and perceived potential of an initiative that developed a promotional tool for a healthy body image, the Québec Charter for a Healthy and Diverse Body Image. The Charter, developed through consensus building by a multisectoral, government-led task force, outlined actions to be undertaken by organizations or citizens to reduce media pressures favoring thinness. Methods. Six months after the Charter’s launch, we surveyed 1003 Québec residents aged 18 years or older about their knowledge of the Charter, their willingness to adhere to it, and their perceptions of its potential. Results. After minimal prompting, more than 35% of respondents recognized the Charter. About 33.7% were very favorable toward personally adhering to the Charter and 32.7% perceived the Charter as having high potential to sensitize people to negative consequences of disordered eating. Women showed greater likelihood and people with lesser education showed lower likelihood of spontaneous recognition. Conclusions. An initiative involving the creation of a body image Charter reaches a substantial portion of adults and is viewed as acceptable and potentially influential. PMID:22698056
Actual and perceived impacts of tobacco regulation on restaurants and firms.
Crémieux, P Y; Ouellette, P
2001-03-01
To examine the actual and anticipated costs of a law regulating workplace smoking and smoking in restaurants, taking into consideration observed and anticipated infrastructure costs, lost productivity, increased absenteeism, and loss of clientele. A survey of 401 Québec restaurants and 600 Québec firms conducted by the Québec Ministry of Health before the enactment of the law was used to derive costs incurred by those who had already complied and anticipated by those that did not. Direct and indirect costs associated with tobacco regulation at work and in restaurants were minimal. Annualised infrastructure costs amounted to less than 0.0002% of firm revenues and 0.15% of restaurant revenues. Anticipated costs were larger and amounted to 0.0004% of firm revenues and 0.41% of restaurant revenues. Impacts on productivity, absenteeism, and restaurant patronage were widely anticipated but not observed in currently compliant establishments. Firms and restaurants expected high costs to result from strict tobacco regulation because of infrastructure costs, decreased productivity, and decreased patronage. That none of these were actually observed suggests that policy makers should discount industry claims that smoking regulations impose undue economic hardship.
Exotic superfluidity and pairing phenomena in atomic Fermi gases in mixed dimensions.
Zhang, Leifeng; Che, Yanming; Wang, Jibiao; Chen, Qijin
2017-10-11
Atomic Fermi gases have been an ideal platform for simulating conventional and engineering exotic physical systems owing to their multiple tunable control parameters. Here we investigate the effects of mixed dimensionality on the superfluid and pairing phenomena of a two-component ultracold atomic Fermi gas with a short-range pairing interaction, while one component is confined on a one-dimensional (1D) optical lattice whereas the other is in a homogeneous 3D continuum. We study the phase diagram and the pseudogap phenomena throughout the entire BCS-BEC crossover, using a pairing fluctuation theory. We find that the effective dimensionality of the non-interacting lattice component can evolve from quasi-3D to quasi-1D, leading to strong Fermi surface mismatch. Upon pairing, the system becomes effectively quasi-two dimensional in the BEC regime. The behavior of T c bears similarity to that of a regular 3D population imbalanced Fermi gas, but with a more drastic departure from the regular 3D balanced case, featuring both intermediate temperature superfluidity and possible pair density wave ground state. Unlike a simple 1D optical lattice case, T c in the mixed dimensions has a constant BEC asymptote.
Nonlocal equation for the superconducting gap parameter
NASA Astrophysics Data System (ADS)
Simonucci, S.; Strinati, G. Calvanese
2017-08-01
The properties are considered in detail of a nonlocal (integral) equation for the superconducting gap parameter, which is obtained by a coarse-graining procedure applied to the Bogoliubov-de Gennes (BdG) equations over the whole coupling-versus-temperature phase diagram associated with the superfluid phase. It is found that the limiting size of the coarse-graining procedure, which is dictated by the range of the kernel of this integral equation, corresponds to the size of the Cooper pairs over the whole coupling-versus-temperature phase diagram up to the critical temperature, even when Cooper pairs turn into composite bosons on the BEC side of the BCS-BEC crossover. A practical method is further implemented to solve numerically this integral equation in an efficient way, which is based on a novel algorithm for calculating the Fourier transforms. Application of this method to the case of an isolated vortex, throughout the BCS-BEC crossover and for all temperatures in the superfluid phase, helps clarifying the nature of the length scales associated with a single vortex and the kinds of details that are in practice disposed off by the coarse-graining procedure on the BdG equations.
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Thompson, A S; Thomsen, L A; Thomson, E; Thomson, M; Thong, W M; Thun, R P; Tian, F; Tibbetts, M J; Tikhomirov, V O; Tikhonov, Yu A; Timoshenko, S; Tiouchichine, E; Tipton, P; Tisserant, S; Todorov, T; Todorova-Nova, S; Toggerson, B; Tojo, J; Tokár, S; Tokushuku, K; Tollefson, K; Tolley, E; Tomlinson, L; Tomoto, M; Tompkins, L; Toms, K; Topilin, N D; Torrence, E; Torres, H; Torró Pastor, E; Toth, J; Touchard, F; Tovey, D R; Tran, H L; Trefzger, T; Tremblet, L; Tricoli, A; Trigger, I M; Trincaz-Duvoid, S; Tripiana, M F; Trischuk, W; Trocmé, B; Troncon, C; Trottier-McDonald, M; Trovatelli, M; True, P; Trzebinski, M; Trzupek, A; Tsarouchas, C; Tseng, J C-L; Tsiareshka, P V; Tsionou, D; Tsipolitis, G; Tsirintanis, N; Tsiskaridze, S; Tsiskaridze, V; Tskhadadze, E G; Tsukerman, I I; Tsulaia, V; Tsuno, S; Tsybychev, D; Tudorache, A; Tudorache, V; Tuna, A N; Tupputi, S A; Turchikhin, S; Turecek, D; Turra, R; Tuts, P M; Tykhonov, A; Tylmad, M; Tyndel, M; Uchida, K; Ueda, I; Ueno, R; Ughetto, M; Ugland, M; Uhlenbrock, M; Ukegawa, F; Unal, G; Undrus, A; Unel, G; Ungaro, F C; Unno, Y; Unverdorben, C; Urbaniec, D; Urquijo, P; Usai, G; Usanova, A; Vacavant, L; Vacek, V; Vachon, B; Valencic, N; Valentinetti, S; Valero, A; Valery, L; Valkar, S; Valladolid Gallego, E; Vallecorsa, S; Valls Ferrer, J A; Van Den Wollenberg, W; Van Der Deijl, P C; van der Geer, R; van der Graaf, H; Van Der Leeuw, R; van der Ster, D; van Eldik, N; van Gemmeren, P; Van Nieuwkoop, J; van Vulpen, I; van Woerden, M C; Vanadia, M; Vandelli, W; Vanguri, R; Vaniachine, A; Vannucci, F; Vardanyan, G; Vari, R; Varnes, E W; Varol, T; Varouchas, D; Vartapetian, A; Varvell, K E; Vazeille, F; Vazquez Schroeder, T; Veatch, J; Veloso, F; Velz, T; Veneziano, S; Ventura, A; Ventura, D; Venturi, M; Venturi, N; Venturini, A; Vercesi, V; Verducci, M; Verkerke, W; Vermeulen, J C; Vest, A; Vetterli, M C; Viazlo, O; Vichou, I; Vickey, T; Vickey Boeriu, O E; Viehhauser, G H A; Viel, S; Vigne, R; Villa, M; Villaplana Perez, M; Vilucchi, E; Vincter, M G; Vinogradov, V B; Virzi, J; Vivarelli, I; Vives Vaque, F; Vlachos, S; Vladoiu, D; Vlasak, M; Vogel, A; Vogel, M; Vokac, P; Volpi, G; Volpi, M; von der Schmitt, H; von Radziewski, H; von Toerne, E; Vorobel, V; Vorobev, K; Vos, M; Voss, R; Vossebeld, J H; Vranjes, N; Vranjes Milosavljevic, M; Vrba, V; Vreeswijk, M; Vu Anh, T; Vuillermet, R; Vukotic, I; Vykydal, Z; Wagner, P; Wagner, W; Wahlberg, H; Wahrmund, S; Wakabayashi, J; Walder, J; Walker, R; Walkowiak, W; Wall, R; Waller, P; Walsh, B; Wang, C; Wang, C; Wang, F; Wang, H; Wang, H; Wang, J; Wang, J; Wang, K; Wang, R; Wang, S M; Wang, T; Wang, X; Wanotayaroj, C; Warburton, A; Ward, C P; Wardrope, D R; Warsinsky, M; Washbrook, A; Wasicki, C; Watkins, P M; Watson, A T; Watson, I J; Watson, M F; Watts, G; Watts, S; Waugh, B M; Webb, S; Weber, M S; Weber, S W; Webster, J S; Weidberg, A R; Weigell, P; Weinert, B; Weingarten, J; Weiser, C; Weits, H; Wells, P S; Wenaus, T; Wendland, D; Weng, Z; Wengler, T; Wenig, S; Wermes, N; Werner, M; Werner, P; Wessels, M; Wetter, J; Whalen, K; White, A; White, M J; White, R; White, S; Whiteson, D; Wicke, D; Wickens, F J; Wiedenmann, W; Wielers, M; Wienemann, P; Wiglesworth, C; Wiik-Fuchs, L A M; Wijeratne, P A; Wildauer, A; Wildt, M A; Wilkens, H G; Will, J Z; Williams, H H; Williams, S; Willis, C; Willocq, S; Wilson, A; Wilson, J A; Wingerter-Seez, I; Winklmeier, F; Winter, B T; Wittgen, M; Wittig, T; Wittkowski, J; Wollstadt, S J; Wolter, M W; Wolters, H; Wosiek, B K; Wotschack, J; Woudstra, M J; Wozniak, K W; Wright, M; Wu, M; Wu, S L; Wu, X; Wu, Y; Wulf, E; Wyatt, T R; Wynne, B M; Xella, S; Xiao, M; Xu, D; Xu, L; Yabsley, B; Yacoob, S; Yakabe, R; Yamada, M; Yamaguchi, H; Yamaguchi, Y; Yamamoto, A; Yamamoto, K; Yamamoto, S; Yamamura, T; Yamanaka, T; Yamauchi, K; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, U K; Yang, Y; Yanush, S; Yao, L; Yao, W-M; Yasu, Y; Yatsenko, E; Yau Wong, K H; Ye, J; Ye, S; Yeletskikh, I; Yen, A L; Yildirim, E; Yilmaz, M; Yoosoofmiya, R; Yorita, K; Yoshida, R; Yoshihara, K; Young, C; Young, C J S; Youssef, S; Yu, D R; Yu, J; Yu, J M; Yu, J; Yuan, L; Yurkewicz, A; Yusuff, I; Zabinski, B; Zaidan, R; Zaitsev, A M; Zaman, A; Zambito, S; Zanello, L; Zanzi, D; Zeitnitz, C; Zeman, M; Zemla, A; Zengel, K; Zenin, O; Ženiš, T; Zerwas, D; Zevi Della Porta, G; Zhang, D; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, X; Zhang, Z; Zhao, Z; Zhemchugov, A; Zhong, J; Zhou, B; Zhou, L; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, N I; Zimmermann, C; Zimmermann, R; Zimmermann, S; Zimmermann, S; Zinonos, Z; Ziolkowski, M; Zobernig, G; Zoccoli, A; Zur Nedden, M; Zurzolo, G; Zutshi, V; Zwalinski, L
The paper presents studies of Bose-Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range [Formula: see text] 100 MeV and [Formula: see text] 2.5 in proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 [Formula: see text]b[Formula: see text], 190 [Formula: see text]b[Formula: see text] and 12.4 nb[Formula: see text] for 0.9 TeV, 7 TeV minimum-bias and 7 TeV high-multiplicity data samples, respectively. The multiplicity dependence of the BEC parameters characterizing the correlation strength and the correlation source size are investigated for charged-particle multiplicities of up to 240. A saturation effect in the multiplicity dependence of the correlation source size parameter is observed using the high-multiplicity 7 TeV data sample. The dependence of the BEC parameters on the average transverse momentum of the particle pair is also investigated.
Sandau, Courtney D; Ayotte, Pierre; Dewailly, Eric; Duffe, Jason; Norstrom, Ross J
2002-01-01
Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is high because of marine-food-based diets--Nunavik (Inuit people) and the Lower North Shore of the Gulf of St. Lawrence (subsistence fishermen)--and a southern Québec urban center where PCB exposure is at background levels (Québec City). The main chlorinated phenolic compound in all regions was PCP. Concentrations of PCP were not significantly different among regions (geometric mean concentration 1,670 pg/g, range 628-7,680 pg/g wet weight in plasma). The ratio of PCP to polychlorinated biphenyl congener number 153 (CB153) concentration ranged from 0.72 to 42.3. Sum HO-PCB (sigma HO-PCBs) concentrations were different among regions, with geometric mean concentrations of 553 (range 238-1,750), 286 (103-788), and 234 (147-464) pg/g wet weight plasma for the Lower North Shore, Nunavik, and the southern Québec groups, respectively. Lower North Shore samples also had the highest geometric mean concentration of sum PCBs (sum of 49 congeners; sigma PCBs), 2,710 (525-7,720) pg/g wet weight plasma. sigma PCB concentrations for Nunavik samples and southern samples were 1,510 (309-6,230) and 843 (290-1,650) pg/g wet weight plasma. Concentrations (log transformed) of sigma HO-PCBs and sigma PCBs were significantly correlated (r = 0.62, p < 0.001), as were concentrations of all major individual HO-PCB congeners and individual PCB congeners. In Nunavik and Lower North Shore samples, free thyroxine (T4) concentrations (log transformed) were negatively correlated with the sum of quantitated chlorinated phenolic compounds (sum PCP and sigma HO-PCBs; r = -0.47, p = 0.01, n = 20) and were not correlated with any PCB congeners or sigma PCBs. This suggests that PCP and HO-PCBs are possibly altering thyroid hormone status in newborns, which could lead to neurodevelopmental effects in infants. Further studies are needed to examine the effects of chlorinated phenolic compounds on thyroid hormone status in newborns. PMID:11940460
All-optical spinor Bose-Einstein condensation and the spinor dynamics-driven atom laser
NASA Astrophysics Data System (ADS)
Lundblad, Nathan Eric
Optical trapping as a viable means of exploring the physics of ultracold dilute atomic gases has revealed a new spectrum of physical phenomena. In particular, macroscopic and sudden occupation of the ground state below a critical temperature---a phenomenon known as Bose-Einstein condensation---has become an even richer system for the study of quantum mechanics, ultracold collisions, and many-body physics in general. Optical trapping liberates the spin degree of the BEC, making the order parameter vectorial ('spinor BEC'), as opposed to the scalar order of traditional magnetically trapped condensates. The work described within is divided into two main efforts. The first encompasses the all-optical creation of a Bose-Einstein condensate in rubidium vapor. An all-optical path to spinor BEC (as opposed to transfer to an optical trap from a magnetic trap condensate) was desired both for the simplicity of the experimental setup and also for the potential gains in speed of creation; evaporative cooling, the only known path to dilute-gas condensation, works only as efficiently as the rate of elastic collisions in the gas, a rate that starts out much higher in optical traps. The first all-optical BEC was formed elsewhere in 2001; the years following saw many groups worldwide seeking to create their own version. Our own all-optical spinor BEC, made with a single-beam dipole trap formed by a focused CO2 laser, is described here, with particular attention paid to trap loading, measurement of trap parameters, and the use of a novel 780 nm high-power laser system. The second part describes initial experiments performed with the nascent condensate. The spinor properties of the condensate are documented, and a measurement is made of the density-dependent rate of spin mixing in the condensate. In addition, we demonstrate a novel dual-beam atom laser formed by outcoupling oppositely polarized components of the condensate, whose populations have been coherently evolved through spin dynamics. We drive coherent spin-mixing evolution through adiabatic compression of the initially weak trap. Such dual beams, nominally number-correlated through the angular momentum-conserving collision 2m0 ⇋ m+1 + m-1 have been proposed as tools to explore entanglement and squeezing in Bose-Einstein condensates.
Étude des déterminants individuels de l’adoption du dossier de santé électronique du Québec
Mezni, H; M-P, Gagnon; Duplantie, J
2016-01-01
Résumé Objectif Selon des études précédentes, les dossiers de santé électroniques peuvent améliorer l’efficacité, la sécurité et la qualité de la prise en charge médicale. Cependant, les prestataires de soins restent réticents quant à son utilisation, ce qui limite son impact sur le système de santé. La présente étude avait pour objectif d’évaluer les perceptions des médecins face au dossier de santé du Québec. Méthodes À partir d’une revue de la littérature sur les facteurs influençant l’adoption des nouvelles technologies de l’information et des communications (NTIC) en général et de la cybersanté en particulier, nous avons élaboré un questionnaire semi-structuré. Au total, 12 médecins utilisateurs potentiels du dossier de santé du Québec (DSQ) ont complété et retourné le questionnaire. Par la suite, nous avons opéré une analyse thématique de contenu, suivie par une théorisation des concepts obtenus. Résultats L’intention d’adopter le DSQ est influencée positivement par l’utilité perçue, la facilité d’utilisation perçue, la démonstrabilité des résultats, la compatibilité du système avec la pratique et l’autoefficacité informatique perçue par les médecins. Inversement, la résistance au changement influence négativement l’adoption du DSQ par les médecins. Conclusion L’identification des déterminants de l’adoption du dossier de santé du Québec est cruciale pour les responsables du secteur de la santé au Québec. Il sera ainsi possible de saisir les attentes des utilisateurs potentiels et d’ajuster les stratégies d’implantation en vue de favoriser une meilleure intégration de cette technologie dans les pratiques médicales. PMID:27867453
A Machine Learning Ensemble Classifier for Early Prediction of Diabetic Retinopathy.
S K, Somasundaram; P, Alli
2017-11-09
The main complication of diabetes is Diabetic retinopathy (DR), retinal vascular disease and it leads to the blindness. Regular screening for early DR disease detection is considered as an intensive labor and resource oriented task. Therefore, automatic detection of DR diseases is performed only by using the computational technique is the great solution. An automatic method is more reliable to determine the presence of an abnormality in Fundus images (FI) but, the classification process is poorly performed. Recently, few research works have been designed for analyzing texture discrimination capacity in FI to distinguish the healthy images. However, the feature extraction (FE) process was not performed well, due to the high dimensionality. Therefore, to identify retinal features for DR disease diagnosis and early detection using Machine Learning and Ensemble Classification method, called, Machine Learning Bagging Ensemble Classifier (ML-BEC) is designed. The ML-BEC method comprises of two stages. The first stage in ML-BEC method comprises extraction of the candidate objects from Retinal Images (RI). The candidate objects or the features for DR disease diagnosis include blood vessels, optic nerve, neural tissue, neuroretinal rim, optic disc size, thickness and variance. These features are initially extracted by applying Machine Learning technique called, t-distributed Stochastic Neighbor Embedding (t-SNE). Besides, t-SNE generates a probability distribution across high-dimensional images where the images are separated into similar and dissimilar pairs. Then, t-SNE describes a similar probability distribution across the points in the low-dimensional map. This lessens the Kullback-Leibler divergence among two distributions regarding the locations of the points on the map. The second stage comprises of application of ensemble classifiers to the extracted features for providing accurate analysis of digital FI using machine learning. In this stage, an automatic detection of DR screening system using Bagging Ensemble Classifier (BEC) is investigated. With the help of voting the process in ML-BEC, bagging minimizes the error due to variance of the base classifier. With the publicly available retinal image databases, our classifier is trained with 25% of RI. Results show that the ensemble classifier can achieve better classification accuracy (CA) than single classification models. Empirical experiments suggest that the machine learning-based ensemble classifier is efficient for further reducing DR classification time (CT).
Georgetown University and Hampton University Prostate Cancer Undergraduate Fellowship Program
2014-09-01
HU-GU Fellow Summer 2013 HU Class of 2015 Kimiko Krieger HU-GU Fellow Summer 2013 HU Class of 2014 Nathan Wilson HU-GU Fellow Summer 2013 HU Class...Tiffany Lumpkin HU-GU Fellow Summer 2010 Class of 2012; Johns Hopkins MS Biotechnology 2013 Zerin Scales HU-GU Fellow Summer 2010 Class of 2013
News from Online: More Spectroscopy
NASA Astrophysics Data System (ADS)
Sweeney Judd, Carolyn
1999-09-01
Absorption (one of three tools) (http://mc2.cchem.berkeley.edu/Chem1A/solar/applets/absorption/ index.html).
Evaporative cooling in a Bose-Einstein condensation ( http://www.colorado.edu/physics/2000/applets/bec.html). Let's start with the spectrum--the electromagnetic spectrum, of course. Go to the EMSpectrum Explorer at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/EMSpectrum /emspectrum.html. Not only do you get information about wavelength, frequency, and energy, but you also get a handy converter that will calculate frequency, wavelength, and energy when one value is entered. And there is more. For example, clicking on red light of 680 nanometers reveals that mitochondria, the power plants of cells, are about the same size as this wavelength, which is also used for photosynthesis. Interesting food for thought! From the EMSpectrum Explorer, go to the Light and Energy page at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/index.html for three Colors of Light Tools. The Color from Emission tool ( http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/emission/index.html) illustrates additive color by mixing differing amounts of Red, Blue, and Green light. Then look at the Color from Absorption tool at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/absorption/index.html. The image from the applet shows the white beam and three filters. Take out the blue, green, and red components by altering the scroll bars or text boxes. The third tool, Removing Color with a Single Filter from Colored Light at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/single/index.html, uses a single filter to take out various colors. Excellent for explaining the theory behind the operation of a basic spectrometer. The Light and Energy tools module, which received support from the National Science Foundation, has been developed under the direction of the ChemLinks Coalition--headed by Beloit College; and The ModularChem Consortium, MC2, headed by the University of California at Berkeley. The Project Director is Marco Molinaro from the University of California at Berkeley; the Project Manager is Susan Walden; Susan Ketchner and Leighanne McConnaughey are also members of the team for this excellent teaching site. For your information, all of the applets will soon be moving, along with the MC2 site, but the old addresses will still work. The next place to explore is Physics 2000 at http://www.colorado.edu/physics/2000/introduction.html. The introductory graphic is a harbinger of good things to come: move the negatively charged particle and see the water molecule spin in response to the position of the charged particle. One goal of the Physics 2000 Educational Initiative is to make physics more accessible to students and people of all ages. Sounds like a good goal for all sciences! One of the first sections is called Einstein's Legacy. Here you can find spectral lines explained in terms of team colors for rival football squads ( http://www.colorado.edu/physics/2000/quantumzone/index.html). Choose from 20 elements to see characteristic emission spectra. The cartoon teachers and students help explain emission spectra. Great applets compare the Bohr atom and the Schrödinger model as well as emission and absorption ( http://www.colorado.edu/physics/2000/quantumzone/schroedinger.html). Einstein's Legacy has many topics: X-rays and CAT Scans, Electromagnetic Waves and Particles, the Quantum Atom, Microwave Ovens, Lasers, and TV & Laptop Screens. Several topics also have sections for the advanced student. One of those advanced sections is part of the second major section of Physics 2000: The Atomic Lab. Two topics are Interference Experiments and Bose-Einstein Condensate. An applet illustrating Laser Cooling is at http://www.colorado.edu/physics/2000/bec/lascool1.html. Next go on to Evaporative Cooling at http://www.colorado.edu/physics/2000/bec/evap_cool.html. The cartoon professors begin the explanation with a picture of steam rising from a cup of hot coffee. Next is an applet with atoms in a parabolic magnetic trap at http://www.colorado.edu/physics/2000/applets/bec.html. The height of the magnetic trap can be changed in order to allow for escape of the most energetic atoms, resulting in cooling so that the Bose-Einstein Condensate is formed. Physics 2000 demands robust computing power. Check the system requirements on the introductory screen before venturing too far into this site. Martin V. Goldman, from the University of Colorado at Boulder, is the Director of Physics 2000, which received support from the Colorado Commission on Higher Education and the National Science Foundation. David Rea is the Technical Director, and many others help make this excellent site possible. Mark your calendars: October 31 through December 3, 1999! Bookmark this site-- http://www.ched-ccce.org/confchem/1999/d/index.html --and sign up. The Winter 1999 CONFCHEM Online Conference will focus on Developments in Spectroscopy and Innovative Strategies for Teaching Spectroscopy in the Undergraduate Curriculum. Scott Van Bramer of Widener University is the conference chair. Experts will present six papers, each to be followed by online discussions. CONFCHEM Online Conferences are sponsored by the American Chemical Society Division of Chemical Education's Committee on Computers in Chemical Education (CCCE). Several Online Conferences are held each year--all are well worth your time. World Wide Web Addresses EMSpectrum Explorer http://mc2.cchem.berkeley.edu/chemcnx/light_energy/EMSpectrum/emspectrum.html Light and Energy http://mc2.cchem.berkeley.edu/chemcnx/light_energy/index.html Emission Spectrum Java Applet http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/emission/index.html Absorption Java Applet http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/absorption/index.html Removing Color with a Single Filter from Colored Light http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/single/index.html Physics 2000 http://www.colorado.edu/physics/2000/introduction.html Einstein's Legacy: Spectral lines http://www.colorado.edu/physics/2000/quantumzone/index.html Einstein's: Schrödinger's Atom http://www.colorado.edu/physics/2000/quantumzone /schroedinger.html The Atomic Lab: Laser Cooling http://www.colorado.edu/physics/2000/bec/lascool1.html The Atomic Lab: Evaporative Cooling in a BoseEinstein Condensation http://www.colorado.edu/physics/2000/bec/evap_cool.html The Winter 1999 CONFCHEM Online Conference will focus on Developments in Spectroscopy and Innovative Strategies for Teaching Spectroscopy in the Undergraduate Curriculum http://www.ched-ccce.org/confchem/1999/d/index.html access date for all sites: July 1999
ERIC Educational Resources Information Center
Rodriguez-Pomeda, Jesus; Casani, Fernando
2016-01-01
Although well-renowned universities attempt to differentiate themselves from other universities, little research has been undertaken on the principal themes involved in the concept of the world-class university (WCU) as presented in speeches by members of WCUs. These discourses are a key tool in universities' attempt to shape the competitive…
Gagnon, Alain; Smith, Ken R; Tremblay, Marc; Vézina, Hélène; Paré, Paul-Philippe; Desjardins, Bertrand
2009-01-01
Frontier populations provide exceptional opportunities to test the hypothesis of a trade-off between fertility and longevity. In such populations, mechanisms favoring reproduction usually find fertile ground, and if these mechanisms reduce longevity, demographers should observe higher postreproductive mortality among highly fertile women. We test this hypothesis using complete female reproductive histories from three large demographic databases: the Registre de la population du Québec ancien (Université de Montréal), which covers the first centuries of settlement in Quebec; the BALSAC database (Université du Québec à Chicoutimi), including comprehensive records for the Saguenay-Lac-St-Jean (SLSJ) in Quebec in the nineteenth and twentieth centuries; and the Utah Population Database (University of Utah), including all individuals who experienced a vital event on the Mormon Trail and their descendants. Together, the three samples allow for comparisons over time and space, and represent one of the largest set of natural fertility cohorts used to simultaneously assess reproduction and longevity. Using survival analyses, we found a negative influence of parity and a positive influence of age at last child on postreproductive survival in the three populations, as well as a significant interaction between these two variables. The effect sizes of all these parameters were remarkably similar in the three samples. However, we found little evidence that early fertility affects postreproductive survival. The use of Heckman's procedure assessing the impact of mortality selection during reproductive ages did not appreciably alter these results. We conclude our empirical investigation by discussing the advantages of comparative approaches. 2009 Wiley-Liss, Inc.
Lu, Pengxin; Parker, William H; Cherry, Marilyn; Colombo, Steve; Parker, William C; Man, Rongzhou; Roubal, Ngaire
2014-01-01
Intraspecific assisted migration (ISAM) through seed transfer during artificial forest regeneration has been suggested as an adaptation strategy to enhance forest resilience and productivity under future climate. In this study, we assessed the risks and benefits of ISAM in white spruce based on long-term and multilocation, rangewide provenance test data. Our results indicate that the adaptive capacity and growth potential of white spruce varied considerably among 245 range-wide provenances sampled across North America; however, the results revealed that local populations could be outperformed by nonlocal ones. Provenances originating from south-central Ontario and southwestern Québec, Canada, close to the southern edge of the species' natural distribution, demonstrated superior growth in more northerly environments compared with local populations and performed much better than populations from western Canada and Alaska, United States. During the 19–28 years between planting and measurement, the southern provenances have not been more susceptible to freezing damage compared with local populations, indicating they have the potential to be used now for the reforestation of more northerly planting sites; based on changing temperature, these seed sources potentially could maintain or increase white spruce productivity at or above historical levels at northern sites. A universal response function (URF), which uses climatic variables to predict provenance performance across field trials, indicated a relatively weak relationship between provenance performance and the climate at provenance origin. Consequently, the URF from this study did not provide information useful to ISAM. The ecological and economic importance of conserving white spruce genetic resources in south-central Ontario and southwestern Québec for use in ISAM is discussed. PMID:25360273
Lu, Pengxin; Parker, William H; Cherry, Marilyn; Colombo, Steve; Parker, William C; Man, Rongzhou; Roubal, Ngaire
2014-06-01
Intraspecific assisted migration (ISAM) through seed transfer during artificial forest regeneration has been suggested as an adaptation strategy to enhance forest resilience and productivity under future climate. In this study, we assessed the risks and benefits of ISAM in white spruce based on long-term and multilocation, rangewide provenance test data. Our results indicate that the adaptive capacity and growth potential of white spruce varied considerably among 245 range-wide provenances sampled across North America; however, the results revealed that local populations could be outperformed by nonlocal ones. Provenances originating from south-central Ontario and southwestern Québec, Canada, close to the southern edge of the species' natural distribution, demonstrated superior growth in more northerly environments compared with local populations and performed much better than populations from western Canada and Alaska, United States. During the 19-28 years between planting and measurement, the southern provenances have not been more susceptible to freezing damage compared with local populations, indicating they have the potential to be used now for the reforestation of more northerly planting sites; based on changing temperature, these seed sources potentially could maintain or increase white spruce productivity at or above historical levels at northern sites. A universal response function (URF), which uses climatic variables to predict provenance performance across field trials, indicated a relatively weak relationship between provenance performance and the climate at provenance origin. Consequently, the URF from this study did not provide information useful to ISAM. The ecological and economic importance of conserving white spruce genetic resources in south-central Ontario and southwestern Québec for use in ISAM is discussed.
Strategic Planning towards a World-Class University
NASA Astrophysics Data System (ADS)
Usoh, E. J.; Ratu, D.; Manongko, A.; Taroreh, J.; Preston, G.
2018-02-01
Strategic planning with a focus on world-class university status is an option that cannot be avoided by universities today to survive and succeed in competition as a provider of higher education. The objective of this research is to obtain exploratory research results on the strategic plans of universities that are prepared to generate world-class university status. This research utilised exploratory qualitative research method and data was collected by in-depth interviews method. Interview transcripts were analyzed by using thematic content analysis through NVivo software analysis and manual systems. The main finding of interview shows that most interviewees agreed that UNIMA has been engaged in strategic planning. Contribution from faculties and schools are acknowledged and inform the planning process. However, a new model of strategic planning should be adopted by UNIMA due to the shift towards a “corporate university”. The finding results from documents, literature review and interview were the addition of world-class university characteristics and features to current strategic planning of UNIMA and how to upgrade by considering to use the characteristics and features towards world-class university.
Dark lump excitations in superfluid Fermi gases
NASA Astrophysics Data System (ADS)
Xu, Yan-Xia; Duan, Wen-Shan
2012-11-01
We study the linear and nonlinear properties of two-dimensional matter-wave pulses in disk-shaped superfluid Fermi gases. A Kadomtsev—Petviashvili I (KPI) solitary wave has been realized for superfluid Fermi gases in the limited cases of Bardeen—Cooper—Schrieffer (BCS) regime, Bose—Einstein condensate (BEC) regime, and unitarity regime. One-lump solution as well as one-line soliton solutions for the KPI equation are obtained, and two-line soliton solutions with the same amplitude are also studied in the limited cases. The dependence of the lump propagating velocity and the sound speed of two-dimensional superfluid Fermi gases on the interaction parameter are investigated for the limited cases of BEC and unitarity.
Thermodynamics and Dynamics of Bose condensation in a quasi-homogeneous gas
NASA Astrophysics Data System (ADS)
Navon, Nir; Schmidutz, Tobias; Gotlibovych, Igor; Gaunt, Alexander; Robert-de-Saint-Vincent, Martin; Smith, Robert; Hadzibabic, Zoran
2014-05-01
We present an experimental study of the thermodynamics and dynamics of Bose-Einstein condensation (BEC) in an optical-box trap. We first characterize the critical point for BEC, and observe saturation of the thermal component in a partially condensed cloud, in agreement with Einstein's textbook picture of a purely statistical phase transition. We also observed the quantum Joule-Thomson effect, namely isoenthalpic cooling of a non-interacting gas. We then investigate the dynamics of Bose condensation in the box potential following a rapid temperature quench through the phase transition, and focus on the time-evolution of the condensed fraction, the coherence length and the mean-field shift, that we probe via Bragg spectroscopy.
NASA Astrophysics Data System (ADS)
Saberi-Pouya, S.; Zarenia, M.; Perali, A.; Vazifehshenas, T.; Peeters, F. M.
2018-05-01
Excitonic superfluidity in double phosphorene monolayers is investigated using the BCS mean-field equations. Highly anisotropic superfluidity is predicted where we found that the maximum superfluid gap is in the Bose-Einstein condensate (BEC) regime along the armchair direction and in the BCS-BEC crossover regime along the zigzag direction. We estimate the highest Kosterlitz-Thouless transition temperature with maximum value up to ˜90 K with onset carrier densities as high as 4 ×1012cm-2 . This transition temperature is significantly larger than what is found in double electron-hole few-layers graphene. Our results can guide experimental research toward the realization of anisotropic condensate states in electron-hole phosphorene monolayers.
Bose-Einstein condensate of rigid rotor molecules
NASA Astrophysics Data System (ADS)
Jones, Evan; Smith, Joseph; Rittenhouse, Seth; Peden, Brandon; Wilson, Ryan
2017-04-01
We study the ground state phases of a quasi-two-dimensional Bose-Einstein condensate (BEC) of dipolar rigid rotor molecules subject to a DC electric field. In the high-field limit, this system acquires the properties of the fully polarized dipolar BEC, which exhibits a roton-maxon excitation spectrum, and has been thoroughly studied in the theoretical literature. In the weak-field limit, however, qualitatively new physics emerges due to the competition between the (weak) applied field and internal electric fields, which are produced by the molecules themselves. We characterize the ground states of this system, and study its unique dielectric properties. We gratefully acknowledge support from the National Science Foundation under Grant No. PHYS-1516421.
Class and University Education: Inter-Generational Patterns in Canada. NALL Working Paper.
ERIC Educational Resources Information Center
Livingstone, D. W.; Stowe, Susan
Young people from lower class origins continue to face major barriers to university education in Canada. This paper documents both substantial inter-generational class mobility and continuing inequalities in formal educational attainments by class origins. While Canada now has the world's higher educational attainments in its youth cohort and has…
ERIC Educational Resources Information Center
Choi, Sheena
2010-01-01
This case study of Yanbian University, a Korean minority university in China, examines the challenges faced, strategies employed, and resources mobilized by a minority university in its attempt to become a world-class university. Specifically, this case study focuses on how the University is attempting to reach its goals within the context of the…
ERIC Educational Resources Information Center
Liu, Lu; Liu, Zhimin
2016-01-01
Due to certainty recognition in ranking systems, the commonly included top 100 universities are regarded as the Universally Acknowledged World-Class Universities (UAWCUs). From three university rankings-THEs, QS and ARWU from 2010 to 2015, the following conclusions can be drawn from this study: Firstly, 56 universities are commonly ranked in the…
Following the Leader? Network Models of "World-Class" Universities on Twitter
ERIC Educational Resources Information Center
Shields, Robin
2016-01-01
Much research on higher education has discussed the positional competition induced by global rankings and the complementary concept of "world-class" universities. This paper investigates the network of social media communication between globally ranked universities. Specifically, it examines whether universities seek to preserve and…
Wei, Xuemei; Liu, Zhen
2018-05-15
BACKGROUND Physical education (PE) is part of the curriculum in Chinese universities. The psychological burden, or anxiety levels, for students in PE classes, can result from several factors, including teaching content, teaching environment, and the organization of the teaching methods. The aim of this study was to assess the psychological burden on students in PE classes in Chinese universities. MATERIAL AND METHODS The study included 400 students (200 men and 200 women) from a Chinese university, who participated in PE classes. The distribution of the levels of psychological burden associated with PE was assessed using subjective measurements and a fuzzy comprehensive evaluation method that to provide an integrated framework combining the results of judgments made at multiple stages of the evaluation process. RESULTS Of the 400 study participants who attended PE classes, 61.5% of male students and 47.5% of female students coped well or very well when dealing with the perceived psychological burden; 33.5% of male students and 42.5% of female students reported a medium level of psychological burden. Few students reported a high level of psychological burden associated with PE classes. The average psychological burden in female students was greater than for male students who participated in PE classes. CONCLUSIONS The combination of subjective measurement of the psychological burden associated with PE classes by university students in China, combined with a fuzzy comprehensive evaluation method showed that female university students might require more support than male students to overcome any psychological burden associated with PE classes.
ERIC Educational Resources Information Center
Chan, Roy Yew-Hung
2011-01-01
This comparative research examined the effects of student involvement and college environment on students' learning and living experience delivered by two aspiring world-class universities in Hong Kong and Shanghai. Few studies have shown how the levels of student involvement and college environment can benefit students at world-class institution.…
Ground state of the time-independent Gross Pitaevskii equation
NASA Astrophysics Data System (ADS)
Dion, Claude M.; Cancès, Eric
2007-11-01
We present a suite of programs to determine the ground state of the time-independent Gross-Pitaevskii equation, used in the simulation of Bose-Einstein condensates. The calculation is based on the Optimal Damping Algorithm, ensuring a fast convergence to the true ground state. Versions are given for the one-, two-, and three-dimensional equation, using either a spectral method, well suited for harmonic trapping potentials, or a spatial grid. Program summaryProgram title: GPODA Catalogue identifier: ADZN_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADZN_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 5339 No. of bytes in distributed program, including test data, etc.: 19 426 Distribution format: tar.gz Programming language: Fortran 90 Computer: ANY (Compilers under which the program has been tested: Absoft Pro Fortran, The Portland Group Fortran 90/95 compiler, Intel Fortran Compiler) RAM: From <1 MB in 1D to ˜10 MB for a large 3D grid Classification: 2.7, 4.9 External routines: LAPACK, BLAS, DFFTPACK Nature of problem: The order parameter (or wave function) of a Bose-Einstein condensate (BEC) is obtained, in a mean field approximation, by the Gross-Pitaevskii equation (GPE) [F. Dalfovo, S. Giorgini, L.P. Pitaevskii, S. Stringari, Rev. Mod. Phys. 71 (1999) 463]. The GPE is a nonlinear Schrödinger-like equation, including here a confining potential. The stationary state of a BEC is obtained by finding the ground state of the time-independent GPE, i.e., the order parameter that minimizes the energy. In addition to the standard three-dimensional GPE, tight traps can lead to effective two- or even one-dimensional BECs, so the 2D and 1D GPEs are also considered. Solution method: The ground state of the time-independent of the GPE is calculated using the Optimal Damping Algorithm [E. Cancès, C. Le Bris, Int. J. Quantum Chem. 79 (2000) 82]. Two sets of programs are given, using either a spectral representation of the order parameter [C.M. Dion, E. Cancès, Phys. Rev. E 67 (2003) 046706], suitable for a (quasi) harmonic trapping potential, or by discretizing the order parameter on a spatial grid. Running time: From seconds in 1D to a few hours for large 3D grids
Myocardial infarction in Québec rural and urban populations between 1995 and 1997.
Loslier, Julie; Vanasse, Alain; Niyonsenga, Théophile; Courteau, Josiane; Orzanco, Gabriela; Hemiari, Abbas
2007-01-01
There is abundant evidence of health inequities between urban and rural populations. The purpose of this paper is to describe the socioeconomic characteristics of Québec urban and rural populations and the relation between rurality and incidence of myocardial infarction (MI), care management and outcomes. Socioeconomic data by census subdivisions were available from the 1996 Canadian census, representing 7,137,245 individuals. Data on patients with MI were taken from the provincial administrative health database (MED-ECHO), which is managed by the Ministry of Health and contains clinical and demographic information collected when patients are released from acute care hospitals in Québec. We included a total of 37,678 cases compiled over the 3 years of follow-up in the analyses. Residents of rural areas with low urban influence have higher MI incidence rates than all of the other populations in the study. In comparison with urban populations, their observed rural counterparts are at a disadvantage with regard to education, employment and income. Although angioplasty and coronary artery bypass graft surgery rates were higher in more urban areas, the survival rate was lower than in rural areas. This study revealed geographic heterogeneity of MI incidence, revascularization rates and survival rates among urban and rural populations.
Gauthier-Ouellet, M.; Dionne, M.; Caron, F.; King, T.L.; Bernatchez, L.
2009-01-01
Mixed-stock fisheries refer to the exploitation of admixed fish stocks coming from different origins. We identified the North American origin of 2835 Atlantic salmon (Salmo salar) in the Greenland mixed-stock fishery during 11 years (1995-2006) at three localities using 13 microsatellites. The study included 52 baseline populations representing nine genetically distinct regional groups. The contribution of each group ranged from <1% (Maine) to 40% (Southern Qu??bec). Decreasing temporal contributions were observed for Southern Qu??bec (-22.0%) and New Brunswick (-17.4%), whereas an increasing contribution for Labrador (+14.9%) was observed during the time course of the study. The estimated regional contribution to the Greenland fishery was significantly correlated to the number of multi-sea-winter salmon regionally produced in 2002 (r = 0.79) and 2004 (r = 0.92). No difference in contribution was found between the three Greenland sampling localities. Ungava and Southern Qu??bec regions showed the highest mortality estimates caused by the fishery, ranging from 12.10% to 18.08%, for both years tested. No regional group was overrepresented in landings compared with their respective productivity. Yet, management precautions should still be taken as the fishery strongly selects large females, which could have evolutionary impacts on populations over the long term.
NASA Astrophysics Data System (ADS)
Matte, Dominic; Thériault, Julie M.; Laprise, René
2018-05-01
Winter weather events with temperatures near 0°C are often associated with freezing rain. They can have major impacts on the society by causing power outages and disruptions to the transportation networks. Despite the catastrophic consequences of freezing rain, very few studies have investigated how their occurrences could evolve under climate change. This study aims to investigate the change of freezing rain and ice pellets over southern Québec using regional climate modeling at high resolution. The fifth-generation Canadian Regional Climate Model with climate scenario RCP 8.5 at 0.11° grid mesh was used. The precipitation types such as freezing rain, ice pellets or their combination are diagnosed using five methods (Cantin and Bachand, Bourgouin, Ramer, Czys and, Baldwin). The occurrences of the diagnosed precipitation types for the recent past (1980-2009) are found to be comparable to observations. The projections for the future scenario (2070-2099) suggested a general decrease in the occurrences of mixed precipitation over southern Québec from October to April. This is mainly due to a decrease in long-duration events (≥6 h ). Overall, this study contributes to better understand how the distribution of freezing rain and ice pellets might change in the future using high-resolution regional climate model.
Stability of matter-wave solitons in optical lattices
NASA Astrophysics Data System (ADS)
Ali, Sk. Golam; Roy, S. K.; Talukdar, B.
2010-08-01
We consider localized states of both single- and two-component Bose-Einstein condensates (BECs) confined in a potential resulting from the superposition of linear and nonlinear optical lattices and make use of Vakhitov-Kolokolov criterion to investigate the effect of nonlinear lattice on the stability of the soliton solutions in the linear optical lattice (LOL). For the single-component case we show that a weak nonlinear lattice has very little effect on the stability of such solitons while sufficiently strong nonlinear optical lattice (NOL) squeezes them to produce narrow bound states. For two-component condensates we find that when the strength of the NOL (γ1) is less than that of the LOL (V0) a relatively weak intra-atomic interaction (IAI) has little effect on the stability of the component solitons. This is true for both attractive and repulsive IAI. A strong attractive IAI, however, squeezes the BEC solitons while a similar repulsive IAI makes the component solitons wider. For γ1 > V0, only a strong attractive IAI squeezes the BEC solitons but the squeezing effect is less prominent than that found for γ1 < V0. We make useful checks on the results of our semianalytical stability analysis by solving the appropriate Gross-Pitaevskii equations numerically.
Effect of Detergents on Galactoside Binding by Melibiose Permeases.
Amin, Anowarul; Hariharan, Parameswaran; Chae, Pil Seok; Guan, Lan
2015-09-29
The effect of various detergents on the stability and function of the melibiose permeases of Escherichia coli (MelBEc) and Salmonella typhimurium (MelBSt) was studied. In n-dodecyl-β-d-maltoside (DDM) or n-undecyl-β-d-maltoside (UDM), WT MelBSt binds melibiose with an affinity similar to that in the membrane. However, with WT MelBEc or MelBSt mutants (Arg141 → Cys, Arg295 → Cys, or Arg363 → Cys), galactoside binding is not detected in these detergents, but binding to the phosphotransferase protein IIA(Glc) is maintained. In the amphiphiles lauryl maltose neopentyl glycol (MNG-3) or glyco-diosgenin (GDN), galactoside binding with all of the MelB proteins is observed, with slightly reduced affinities. MelBSt is more thermostable than MelBEc, and the thermostability of either MelB is largely increased in MNG-3 or GDN. Therefore, the functional defect with DDM or UDM likely results from the relative instability of the sensitive MelB proteins, and stability, as well as galactoside binding, is retained in MNG-3 or GDN. Furthermore, isothermal titration calorimetry of melibiose binding with MelBSt shows that the favorable entropic contribution to the binding free energy is decreased in MNG-3, indicating that the conformational dynamics of MelB is restricted in this detergent.
Effect of detergents on galactoside binding by melibiose permeases
Amin, Anowarul; Hariharan, Parameswaran; Chae, Pil Seok; Guan, Lan
2015-01-01
The effect of various detergents on the stability and function of melibiose permeases of Escherichia coli (MelBEc) or Salmonella typhimurium (MelBSt) were studied. In n-dodecyl-β-d-maltoside (DDM) or n-undecyl-β-d-maltoside (UDM), WT MelBSt binds melibiose with an affinity similar to that in the membrane. However, with WT MelBEc or MelBSt mutants (Arg141→Cys, Arg295→Cys or Arg363→Cys), galactoside binding is not detected in these detergents, but binding to the phosphotransferase protein IIAGlc is maintained. In the amphiphiles lauryl maltose neopentyl glycol (MNG-3) or glyco-diosgenin (GDN), galactoside binding with all the MelB proteins is observed, with slightly reduced affinities. MelBSt is more thermostable than MelBEc, and the thermostability of either MelB is largely increased in MNG-3 or GDN. Therefore, the functional defect with DDM or UDM likely results from relative instability of the sensitive MelB proteins, and stability, as well as galactoside binding, is retained in MNG-3 or GDN. Furthermore, isothermal titration calorimetry of melibiose binding with MelBSt shows that the favorable entropic contribution to the binding free energy is decreased in MNG-3, indicating that the conformational dynamics of MelB is restricted in this detergent. PMID:26352464
Workplace psychological harassment: Gendered exposures and implications for policy.
Lippel, Katherine; Vézina, Michel; Bourbonnais, Renée; Funes, Amélie
2016-01-01
This article reports on the results of an empirical study of working conditions including psychological harassment (workplace bullying) in the province of Québec, Canada, the first North American jurisdiction to regulate psychological harassment in its labor legislation. All empirical data provided in this article was drawn from the Québec Survey on Working, Employment and Occupational Health and Safety Conditions, conducted through 5071 telephone interviews of a representative sample of Québec workers, including the self-employed. Here we focus on employees, and provide bivariate and multivariate analyses. All analyses were stratified by gender. We provide a portrait of exposure to psychological harassment, and exposure to other psychosocial factors in the workplace associated with exposure to psychological harassment. Results show associations between exposure to psychological harassment and negative health measures including psychological distress, symptoms of depression, traumatic work accidents, musculoskeletal disorders and negative perception of health status. We report on steps taken by employees to put an end to the harassment. Gender similarities and differences in exposure, associated risk factors, health measures and strategies are presented and discussed in light of the legal context in which the study took place. We conclude with recommendations for prevention strategies that take into consideration the gender composition of the workplace. Copyright © 2016 Elsevier Ltd. All rights reserved.
Tunable Bistability in Hybrid Bose-Einstein Condensate Optomechanics
Yasir, Kashif Ammar; Liu, Wu-Ming
2015-01-01
Cavity-optomechanics, a rapidly developing area of research, has made a remarkable progress. A stunning manifestation of optomechanical phenomena is in exploiting the mechanical effects of light to couple the optical degree of freedom with mechanical degree of freedom. In this report, we investigate the controlled bistable dynamics of such hybrid optomechanical system composed of cigar-shaped Bose-Einstein condensate (BEC) trapped inside high-finesse optical cavity with one moving-end mirror and is driven by a single mode optical field. The numerical results provide evidence for controlled optical bistability in optomechanics using transverse optical field which directly interacts with atoms causing the coupling of transverse field with momentum side modes, exited by intra-cavity field. This technique of transverse field coupling is also used to control bistable dynamics of both moving-end mirror and BEC. The report provides an understanding of temporal dynamics of moving-end mirror and BEC with respect to transverse field. Moreover, dependence of effective potential of the system on transverse field has also been discussed. To observe this phenomena in laboratory, we have suggested a certain set of experimental parameters. These findings provide a platform to investigate the tunable behavior of novel phenomenon like electromagnetically induced transparency and entanglement in hybrid systems. PMID:26035206
NASA Astrophysics Data System (ADS)
Li, Chuan-Hsun; Blasing, David; Chen, Yong
2017-04-01
In cold atom systems, spin excitations have been shown to be a sensitive probe of interactions and quantum statistical effects, and can be used to study spin transport in both Fermi and Bose gases. In particular, spin-dipole mode (SDM) is a type of excitation that can generate a spin current without a net mass current. We present recent measurements and analysis of SDM in a disorder-free, interacting three-dimensional (3D) 87Rb Bose-Einstein condensate (BEC) by applying spin-dependent synthetic electric fields to actuate head-on collisions between two BECs of different spin states. We experimentally study and compare the behaviors of the system following SDM excitations in the presence as well as absence of synthetic 1D spin-orbit coupling (SOC). We find that in the absence of SOC, SDM is relatively weakly damped, accompanied with collision-induced thermalization which heats up the atomic cloud. However, in the presence of SOC, we find that SDM is more strongly damped with reduced thermalization, and observe excitation of a quadrupole mode that exhibits BEC shape oscillation even after SDM is damped out. Such a mode conversion bears analogies with the Beliaev coupling process or the parametric frequency down conversion of light in nonlinear optics.
Metastability versus collapse following a quench in attractive Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Golde, Jake; Ruhl, Joanna; Olshanii, Maxim; Dunjko, Vanja; Datta, Sumita; Malomed, Boris A.
2018-05-01
We consider a Bose-Einstein condensate (BEC) with attractive two-body interactions in a cigar-shaped trap, initially prepared in its ground state for a given negative scattering length, which is quenched to a larger absolute value of the scattering length. Using the mean-field approximation, we compute numerically, for an experimentally relevant range of aspect ratios and initial strengths of the coupling, two critical values of quench. One corresponds to the weakest attraction strength, the quench to which causes the system to collapse before completing even a single return from the narrow configuration (pericenter) in its breathing cycle. The other is a similar critical point for the occurrence of collapse before completing two returns. In the latter case, we also compute the limiting value, as we keep increasing the strength of the postquench attraction towards its critical value, of the time interval between the first two pericenters. We also use a Gaussian variational model to estimate the critical quenched attraction strength below which the system is stable against the collapse for long times. These time intervals and critical attraction strengths, apart from being fundamental properties of nonlinear dynamics of self-attractive BECs, may provide clues to the design of upcoming experiments that are trying to create robust BEC breathers.
Dabigatran abrogates brain endothelial cell permeability in response to thrombin
Hawkins, Brian Thomas; Gu, Yu-Huan; Izawa, Yoshikane; del Zoppo, Gregory John
2015-01-01
Atrial fibrillation (AF) increases the risk and severity of thromboembolic stroke. Generally, antithrombotic agents increase the hemorrhagic risk of thromboembolic stroke. However, significant reductions in thromboembolism and intracerebral hemorrhage have been shown with the antithrombin dabigatran compared with warfarin. As thrombin has been implicated in microvessel injury during cerebral ischemia, we hypothesized that dabigatran decreases the risk of intracerebral hemorrhage by direct inhibition of the thrombin-mediated increase in cerebral endothelial cell permeability. Primary murine brain endothelial cells (mBECs) were exposed to murine thrombin before measuring permeability to 4-kDa fluorescein isothiocyanate-dextran. Thrombin increased mBEC permeability in a concentration-dependent manner, without significant endothelial cell death. Pretreatment of mBECs with dabigatran completely abrogated the effect of thrombin on permeability. Neither the expressions of the endothelial cell β1-integrins nor the tight junction protein claudin-5 were affected by thrombin exposure. Oxygen-glucose deprivation (OGD) also increased permeability; this effect was abrogated by treatment with dabigatran, as was the additive effect of thrombin and OGD on permeability. Taken together, these results indicate that dabigatran could contribute to a lower risk of intracerebral hemorrhage during embolism-associated ischemia from AF by protection of the microvessel permeability barrier from local thrombin challenge. PMID:25669912
NASA Astrophysics Data System (ADS)
Lombardi, G.; Van Alphen, W.; Klimin, S. N.; Tempere, J.
2017-09-01
In the present article the snake instability mechanism for dark solitons in superfluid Fermi gases is studied in the context of a recently developed effective field theory [S. N. Klimin et al., Eur. Phys. J. B 88, 122 (2015), 10.1140/epjb/e2015-60213-4]. This theoretical treatment has proven to be suitable to study stable dark solitons in quasi-one-dimensional setups across the BEC-BCS crossover. In this paper the nodal plane of the stable soliton solution is perturbed by adding a transverse modulation. The numerical solution of the system of coupled nonlinear differential equations describing the amplitude of the perturbation leads to an estimate of the growth rate and characteristic length scale of the instability, which are calculated for a wide range of interaction regimes and compared to other theoretical predictions. The behavior of the maximum transverse size that the atomic cloud can have in order to preserve the stability is described across the BEC-BCS crossover. The analysis of the effects of spin imbalance on this critical length reveals a stabilization of the soliton with increasing imbalance and therefore provides the experimental community with a method to achieve the realization of stable solitons in real three-dimensional configurations, without reducing the system dimensionality.
Fibonacci family of dynamical universality classes.
Popkov, Vladislav; Schadschneider, Andreas; Schmidt, Johannes; Schütz, Gunter M
2015-10-13
Universality is a well-established central concept of equilibrium physics. However, in systems far away from equilibrium, a deeper understanding of its underlying principles is still lacking. Up to now, a few classes have been identified. Besides the diffusive universality class with dynamical exponent [Formula: see text], another prominent example is the superdiffusive Kardar-Parisi-Zhang (KPZ) class with [Formula: see text]. It appears, e.g., in low-dimensional dynamical phenomena far from thermal equilibrium that exhibit some conservation law. Here we show that both classes are only part of an infinite discrete family of nonequilibrium universality classes. Remarkably, their dynamical exponents [Formula: see text] are given by ratios of neighboring Fibonacci numbers, starting with either [Formula: see text] (if a KPZ mode exist) or [Formula: see text] (if a diffusive mode is present). If neither a diffusive nor a KPZ mode is present, all dynamical modes have the Golden Mean [Formula: see text] as dynamical exponent. The universal scaling functions of these Fibonacci modes are asymmetric Lévy distributions that are completely fixed by the macroscopic current density relation and compressibility matrix of the system and hence accessible to experimental measurement.
Paths for World-Class Universities in Agricultural Science
ERIC Educational Resources Information Center
Liu, Zhimin; Kipchumba, Simon Kibet; Liu, Lu
2016-01-01
The top-ranking world-class universities in agricultural science denote those universities which are globally popular with agriculture-related subjects. The paper synthesizes the results of three different ranking scales (NTU, QS and ARWU) of top 50 universities in agriculture subject in 2013. The overlapped parts have been synchronized to derive…
Krizbai, István A.; Gasparics, Ákos; Nagyőszi, Péter; Fazakas, Csilla; Molnár, Judit; Wilhelm, Imola; Bencs, Rita; Rosivall, László; Sebe, Attila
2015-01-01
Cancer progression towards metastasis follows a defined sequence of events described as the metastatic cascade. For extravasation and transendothelial migration metastatic cells interact first with endothelial cells. Yet the role of endothelial cells during the process of metastasis formation and extravasation is still unclear, and the interaction between metastatic and endothelial cells during transendothelial migration is poorly understood. Since tumor cells are well known to express TGF-β, and the compact endothelial layer undergoes a series of changes during metastatic extravasation (cell contact disruption, cytoskeletal reorganization, enhanced contractility), we hypothesized that an EndMT may be necessary for metastatic extravasation. We demonstrate that primary cultured rat brain endothelial cells (BEC) undergo EndMT upon TGF-β1 treatment, characterized by the loss of tight and adherens junction proteins, expression of fibronectin, β1-integrin, calponin and α-smooth muscle actin (SMA). B16/F10 cell line conditioned and activated medium (ACM) had similar effects: claudin-5 down-regulation, fibronectin and SMA expression. Inhibition of TGF-β signaling during B16/F10 ACM stimulation using SB-431542 maintained claudin-5 levels and mitigated fibronectin and SMA expression. B16/F10 ACM stimulation of BECs led to phosphorylation of Smad2 and Smad3. SB-431542 prevented SMA up-regulation upon stimulation of BECs with A2058, MCF-7 and MDA-MB231 ACM as well. Moreover, B16/F10 ACM caused a reduction in transendothelial electrical resistance, enhanced the number of melanoma cells adhering to and transmigrating through the endothelial layer, in a TGF-β-dependent manner. These effects were not confined to BECs: HUVECs showed TGF-β-dependent SMA expression when stimulated with breast cancer cell line ACM. Our results indicate that an EndMT may be necessary for metastatic transendothelial migration, and this transition may be one of the potential mechanisms occurring during the complex phenomenon known as metastatic extravasation. PMID:25742314
Sasaki, Motoko; Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni
2012-03-01
Given autophagy is involved in the pathogenesis in primary biliary cirrhosis (PBC), we examined an involvement of p62 sequestosome-1 (p62), a specific cargo for autophagy, in the process of autophagy and cellular senescence in PBC. We examined immunohistochemically the expression of p62 in livers taken from patients with PBC (n = 46) and control livers (n = 78) and its colocalization with microtubule-associated proteins-light chain 3β (LC3), lysosome-associated membrane protein-1 (LAMP-1) and senescent markers (p16(INK) (4a) and p21(WAF) (1/Cip1) ). We examined the expression of p62 and LC3 in cultured biliary epithelial cells (BECs) treated with various stress. The effect of p62 knockdown with siRNA on stress-induced autophagy and cellular senescence was also assessed. The expression of p62 was specifically seen in cytoplasmic aggregates in BECs in the inflamed and damaged small bile ducts (SBDs) in PBC, when compared with non-inflamed ones in PBC and in control livers (P < 0.01). The co-expression of p62 with LC3, LAMP-1 and senescent markers was seen in the inflamed SBDs in PBC, but the intracytoplasmic localization was different. The expression of p62 and LC3 was significantly upregulated in BECs treated with various stress (P < 0.01) and pretreatment with bafilomycin A1 enhanced the accumulation of p62-positive aggregates in BECs with serum deprivation. The knockdown of p62 decreased stress-induced autophagy and cellular senescence. The aggregation of p62 is specifically increased in the damage bile ducts in PBC and may reflect dysfunctional autophagy, followed by cellular senescence in the pathogenesis of bile duct lesions in PBC. © 2011 John Wiley & Sons A/S.
BCS-BEC crossover and quantum hydrodynamics in p-wave superfluids with a symmetry of the A1 phase
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kagan, M. Yu., E-mail: kagan@kapitza.ras.ru; Efremov, D. V.
2010-03-15
We solve the Leggett equations for the BCS-BEC crossover in a three dimensional resonance p-wave superfluid with the symmetry of the A1 phase. We calculate the sound velocity, the normal density, and the specific heat for the BCS domain ({mu} > 0), for the BEC domain ({mu} < 0), and close to the important point {mu} = 0 in the 100% polarized case. We find the indications of a quantum phase transition close to the point {mu}(T = 0) = 0. Deep in the BCS and BEC domains, the crossover ideas of Leggett, Nozieres, and Schmitt-Rink work quite well. Wemore » discuss the spectrum of orbital waves, the paradox of intrinsic angular momentum and the complicated problem of chiral anomaly in the BCS A1 phase at T = 0. We present two different approaches to the chiral anomaly, based on supersymmetric hydrodynamics and on the formal analogy with the Dirac equation in quantum electrodynamics. We evaluate the damping of nodal fermions due to different decay processes in the superclean case at T = 0 and find that a ballistic regime {omega}{tau} >> 1 occurs. We propose to use aerogel or nonmagnetic impurities to reach the hydrodynamic regime {omega}{tau} << 1 at T = 0. We discuss the concept of the spectral flow and exact cancelations between time derivatives of anomalous and quasiparticle currents in the equation for the total linear momentum conservation. We propose to derive and solve the kinetic equation for the nodal quasiparticles in both the hydrodynamic and ballistic regimes to demonstrate this cancelation explicitly. We briefly discuss the role of the other residual interactions different from damping and invite experimentalists to measure the spectrum and damping of orbital waves in the A phase of {sup 3}He at low temperatures.« less
An Analysis of the Perceptions and Resources of Large University Classes
ERIC Educational Resources Information Center
Cash, Ceilidh Barlow; Letargo, Jessa; Graether, Steffen P.; Jacobs, Shoshanah R.
2017-01-01
Large class learning is a reality that is not exclusive to the first-year experience at midsized, comprehensive universities; upper-year courses have similarly high enrollment, with many class sizes greater than 200 students. Research into the efficacy and deficiencies of large undergraduate classes has been ongoing for more than 100 years, with…
NASA Astrophysics Data System (ADS)
Lowney, Joseph Daniel
Methods to generate, manipulate, and measure optical and atomic fields with global or local angular momentum have a wide range of applications in both fundamental physics research and technology development. In optics, the engineering of angular momentum states of light can aid studies of orbital angular momentum (OAM) exchange between light and matter. The engineering of optical angular momentum states can also be used to increase the bandwidth of optical communications or serve as a means to distribute quantum keys, for example. Similar capabilities in Bose-Einstein condensates are being investigated to improve our understanding of superfluid dynamics, superconductivity, and turbulence, the last of which is widely considered to be one of most ubiquitous yet poorly understood subjects in physics. The first part of this two-part dissertation presents an analysis of techniques for measuring and manipulating quantized vortices in BECs. The second part of this dissertation presents theoretical and numerical analyses of new methods to engineer the OAM spectra of optical beams. The superfluid dynamics of a BEC are often well described by a nonlinear Schrodinger equation. The nonlinearity arises from interatomic scattering and enables BECs to support quantized vortices, which have quantized circulation and are fundamental structural elements of quantum turbulence. With the experimental tools to dynamically manipulate and measure quantized vortices, BECs are proving to be a useful medium for testing the theoretical predictions of quantum turbulence. In this dissertation we analyze a method for making minimally destructive in situ observations of quantized vortices in a BEC. Secondly, we numerically study a mechanism to imprint vortex dipoles in a BEC. With these advancements, more robust experiments of vortex dynamics and quantum turbulence will be within reach. A more complete understanding of quantum turbulence will enable principles of microscopic fluid flow to be related to the statistical properties of turbulence in a superfluid. In the second part of this dissertation we explore frequency mixing, a subset of nonlinear optical processes in which one or more input optical beam(s) are converted into one or more output beams with different optical frequencies. The ability of parametric nonlinear processes such as second harmonic generation or parametric amplification to manipulate the OAM spectra of optical beams is an active area of research. In a theoretical and numerical investigation, two complimentary methods for sculpting the OAM spectra are developed. The first method employs second harmonic generation with two non-collinear input beams to develop a broad spectrum of OAM states in an optical field. The second method utilizes parametric amplification with collinear input beams to develop an OAM-dependent gain or attenuation, termed dichroism for OAM, to effectively narrow the OAM spectrum of an optical beam. The theoretical principles developed in this dissertation enhance our understanding of how nonlinear processes can be used to engineer the OAM spectra of optical beams and could serve as methods to increase the bandwidth of an optical signal by multiplexing over a range of OAM states.
ERIC Educational Resources Information Center
Guangkuan, Xie
2013-01-01
Strategic planning plays an important but sometimes controversial role in higher education. This paper examines how strategic planning works in Chinese universities, using Peking University as a case study. This essay discusses the rationale for why Peking University (PKU) decided to pursue status as a world-class university along with objectives…
Nearing World-Class: Singapore's Two Universities in QSWUR 2015/16
ERIC Educational Resources Information Center
Soh, Kaycheng
2016-01-01
Many universities strive to become world-class and two of Singapore's universities are almost there, being ranked 12th and 13th in the QSWUR 2015/16. This study looked into the details of indicator rankings and found that the two universities are comparable to those in the top 10 universities in the same ranking in practically all indicators with…
The Global Quest to Build World-Class Universities: Toward a Social Justice Agenda
ERIC Educational Resources Information Center
Rhoads, Robert A.; Li, Shuai; Ilano, Lauren
2014-01-01
This chapter provides a critical perspective on the global quest to build world-class universities (WCUs), including global "ranking mania," excessive emphasis on university branding, and the attending threats to the traditional public good mission of the university. Alternatively, we offer suggestions on how rankings may be used to…
Teenage Expectations of Going to University: The EBB and Flow of Influences from 14 to 18
ERIC Educational Resources Information Center
Winterton, Mandy Teresa; Irwin, Sarah
2012-01-01
The expansion of higher education in the UK has been accompanied by ongoing class related inequalities in expectations about, and access to, university. In the context of detailed research into middle-class and working-class experiences and difference, there have been calls for more detailed analysis of internal class diversity, and for…
Krug, L M; Grant, S C; Miller, V A; Ng, K K; Kris, M G
1999-10-01
In the last 25 years, treatment for small cell lung cancer (SCLC) has improved with advances in chemotherapy and radiotherapy. Standard chemotherapy regimens can yield 80% to 90% response rates and some cures when combined with thoracic irradiation in limited-stage patients. Nonetheless, small cell lung cancer has a high relapse rate due to drug resistance; this has resulted in poor survival for most patients. Attacking this problem requires a unique approach to eliminate resistant disease remaining after induction therapy. This review will focus on three potential strategies: high-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination.
Horizon in random matrix theory, the Hawking radiation, and flow of cold atoms.
Franchini, Fabio; Kravtsov, Vladimir E
2009-10-16
We propose a Gaussian scalar field theory in a curved 2D metric with an event horizon as the low-energy effective theory for a weakly confined, invariant random matrix ensemble (RME). The presence of an event horizon naturally generates a bath of Hawking radiation, which introduces a finite temperature in the model in a nontrivial way. A similar mapping with a gravitational analogue model has been constructed for a Bose-Einstein condensate (BEC) pushed to flow at a velocity higher than its speed of sound, with Hawking radiation as sound waves propagating over the cold atoms. Our work suggests a threefold connection between a moving BEC system, black-hole physics and unconventional RMEs with possible experimental applications.
Berke, Ethan M; Vernez-Moudon, Anne
2014-06-01
As research examining the effect of the built environment on health accelerates, it is critical for health and planning researchers to conduct studies and make recommendations in the context of a robust theoretical framework. We propose a framework for built environment change (BEC) related to improving health. BEC consists of elements of the built environment, how people are exposed to and interact with them perceptually and functionally, and how this exposure may affect health-related behaviours. Integrated into this framework are the legal and regulatory mechanisms and instruments that are commonly used to effect change in the built environment. This framework would be applicable to medical research as well as to issues of policy and community planning.
Induced interaction in a Fermi gas with a BEC-BCS crossover
DOE Office of Scientific and Technical Information (OSTI.GOV)
Yu Zengqiang; Huang Kun; Yin Lan
2009-05-15
We study the effect of the induced interaction on the superfluid transition temperature of a Fermi gas with a Bose-Einstein condensation-Bardeen-Cooper-Schrieffer (BEC-BCS) crossover. The Gorkov-Melik-Barkhudarov theory about the induced interaction is extended from the BCS side to the entire crossover and the pairing fluctuation is treated in the approach by Nozieres and Schmitt-Rink. At unitarity, the induced interaction reduces the transition temperature by about 20%. In the BCS limit, the transition temperature is reduced by a factor of about 2.22, as found by Gorkov and Melik-Barkhudarov. Our result shows that the effect of the induced interaction is important both onmore » the BCS side and in the unitary region.« less
Three-dimensional vortex-bright solitons in a spin-orbit-coupled spin-1 condensate
NASA Astrophysics Data System (ADS)
Gautam, Sandeep; Adhikari, S. K.
2018-01-01
We demonstrate stable and metastable vortex-bright solitons in a three-dimensional spin-orbit-coupled three-component hyperfine spin-1 Bose-Einstein condensate (BEC) using numerical solution and variational approximation of a mean-field model. The spin-orbit coupling provides attraction to form vortex-bright solitons in both attractive and repulsive spinor BECs. The ground state of these vortex-bright solitons is axially symmetric for weak polar interaction. For a sufficiently strong ferromagnetic interaction, we observe the emergence of a fully asymmetric vortex-bright soliton as the ground state. We also numerically investigate moving solitons. The present mean-field model is not Galilean invariant, and we use a Galilean-transformed mean-field model for generating the moving solitons.
NASA Astrophysics Data System (ADS)
Nwokoye, Chidubem; Della Torre, Edward; Bennett, Lawrence; Siddique, Abid; Narducci, Frank A.
2015-04-01
Magneto-optic Kerr effect, MOKE, is used to observe the complex rotation of the polarization plane of linearly polarized incident light reflected from the surface of a magnetic material. The rotation is directly related to the surface magnetization of the material. We report work that extends the experiments in that studied Bose-Einstein Condensation (BEC) of magnons in confined nanostructures. We report the MOKE experimental results of an investigation of surface magnetic remanence and coercivity on a Co/Pt ferromagnetic thin film at low-temperatures. Our findings are explained and are attributed to the BEC of confined magnons in the Co/Pt thin film. We recognize financial support from the Naval Air Systems Command Section 219 grant.
ERIC Educational Resources Information Center
Karlinski, Jean
2007-01-01
The University of British Columbia's Planning and Institutional Research office prepared a research report for the BC Council on Admissions and Transfer (BCCAT) on the BC university graduating class of 1996 five years later. The report compared the outcomes for those students who were admitted to SFU, UBC, UNBC, and UVic as BC direct entry with…
Fibonacci family of dynamical universality classes
Popkov, Vladislav; Schadschneider, Andreas; Schmidt, Johannes; Schütz, Gunter M.
2015-01-01
Universality is a well-established central concept of equilibrium physics. However, in systems far away from equilibrium, a deeper understanding of its underlying principles is still lacking. Up to now, a few classes have been identified. Besides the diffusive universality class with dynamical exponent z=2, another prominent example is the superdiffusive Kardar−Parisi−Zhang (KPZ) class with z=3/2. It appears, e.g., in low-dimensional dynamical phenomena far from thermal equilibrium that exhibit some conservation law. Here we show that both classes are only part of an infinite discrete family of nonequilibrium universality classes. Remarkably, their dynamical exponents zα are given by ratios of neighboring Fibonacci numbers, starting with either z1=3/2 (if a KPZ mode exist) or z1=2 (if a diffusive mode is present). If neither a diffusive nor a KPZ mode is present, all dynamical modes have the Golden Mean z=(1+5)/2 as dynamical exponent. The universal scaling functions of these Fibonacci modes are asymmetric Lévy distributions that are completely fixed by the macroscopic current density relation and compressibility matrix of the system and hence accessible to experimental measurement. PMID:26424449
A Great Leap Forward to Excellence in Research at Seoul National University, 1994-2006
ERIC Educational Resources Information Center
Kim, Ki-Seok
2007-01-01
This paper addresses to the question of how to empower research competence of a kind which would lead a peripheral university like SNU to becoming a world-class university. There have been noticeable achievements in building competitive, first class universities in many developing nations, particularly in Asian countries. This paper will examine…
Global Rankings, World-Class Universities and Dilemma in Higher Education Policy in India
ERIC Educational Resources Information Center
Tilak, Jandhyala B. G.
2016-01-01
Global university rankings and world-class universities have become buzzwords almost in every country. Both exercise positive and not-so-positive impact on higher education systems. Universities everywhere are trying hard to improve their status and global rankings. The article reviews some of the important issues related to these two strongly…
In the Shadow of Celebrity? World-Class University Policies and Public Value in Higher Education
ERIC Educational Resources Information Center
Cremonini, Leon; Westerheijden, Don F.; Benneworth, Paul; Dauncey, Hugh
2014-01-01
The growing popularity of the concept of world-class universities raises the question of whether investing in such universities is a worthwhile use of public resources. Does concentrating public resources on the most excellent universities improve the overall quality of a higher education system, especially if definitions of excellence and…
ERIC Educational Resources Information Center
Dysterheft, Jennifer; Chaparro, Gioella; Rice, Laura; Rice, Ian
2018-01-01
The purpose of this study was to determine whether university students with physical disabilities (SWD) gained similar benefits from recreational physical activity participation as able-bodied (AB) university students as reported in the literature. Researchers designed an inclusive, university-offered aquatic exercise class for SWD. Six SWD…
ERIC Educational Resources Information Center
Danielsson, Anna T.
2014-01-01
This article explores how the doing of social class and gender can intersect with the learning of science, through case studies of two male, working-class university students' constitutions of identities as physics students. In doing so, I challenge the taken-for-granted notion that male physics students have an unproblematic relation to…
Informal Learning: A Lived Experience in a University Musicianship Class
ERIC Educational Resources Information Center
Mok, Annie O.
2017-01-01
This study investigates how a class of university music students who engaged in a "lived" experience of informal learning adopted methods and strategies to complete a self-learning "aural copying" performance assignment in a musicianship class in Hong Kong. Data were collected from observations of the performances and the…
Texture Mixing via Universal Simulation
2005-08-01
classes and universal simulation. Based on the well-known Lempel and Ziv (LZ) universal compression scheme, the universal type class of a one...length that produce the same tree (dictionary) under the Lempel - Ziv (LZ) incre- mental parsing defined in the well-known LZ78 universal compression ...the well known Lempel - Ziv parsing algorithm . The goal is not just to synthesize mixed textures, but to understand what texture is. We are currently
ERIC Educational Resources Information Center
Intsiful, Emmanuel; Maassen, Peter
2017-01-01
Despite its seemingly subjective and ambiguous nature, the notion of a World Class University (WCU) appears both established and widely discussed in higher education discourses over the last decade. At the same time, some scholars have argued that the notion does not fit or refer to universities in Africa. In the year 2010, the University of Ghana…
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bijnen, R. M. W. van; Department of Physics and Astronomy, McMaster University, Hamilton, Ontario L8S 4M1; Parker, N. G.
We present a general method for obtaining the exact static solutions and collective excitation frequencies of a trapped Bose-Einstein condensate (BEC) with dipolar atomic interactions in the Thomas-Fermi regime. The method incorporates analytic expressions for the dipolar potential of an arbitrary polynomial density profile, thereby reducing the problem of handling nonlocal dipolar interactions to the solution of algebraic equations. We comprehensively map out the static solutions and excitation modes, including non-cylindrically-symmetric traps, and also the case of negative scattering length where dipolar interactions stabilize an otherwise unstable condensate. The dynamical stability of the excitation modes gives insight into the onsetmore » of collapse of a dipolar BEC. We find that global collapse is consistently mediated by an anisotropic quadrupolar collective mode, although there are two trapping regimes in which the BEC is stable against quadrupole fluctuations even as the ratio of the dipolar to s-wave interactions becomes infinite. Motivated by the possibility of a fragmented condensate in a dipolar Bose gas due to the partially attractive interactions, we pay special attention to the scissors modes, which can provide a signature of superfluidity, and identify a long-range restoring force which is peculiar to dipolar systems. As part of the supporting material for this paper we provide the computer program used to make the calculations, including a graphical user interface.« less
Comparing women's assessment of midwifery and medical care in Québec, Canada.
De Koninck, M; Blais, R; Joubert, P; Gagnon, C
2001-01-01
In 1990, the province of Québec, Canada, adopted a law that authorized the evaluation of the practice of midwifery through pilot projects before its legalization. A key objective of this evaluation, as defined by the law, was the documentation of women's assessment of maternity care, especially with regard to humanization and continuity of care. Two to 3 months after birth, 933 midwifery clients and 1,000 physicians' clients, matched on several characteristics, responded to a mailed questionnaire (response rates were 93% and 76%, respectively). Results showed that women from both groups were generally satisfied with the care they received, although women who received midwifery care were assessed as more positive on every issue surveyed. Objective measures supported impressions that were also confirmed through qualitative data analysis: midwifery clients had a greater number of and longer prenatal visits, their care was perceived to be more personalized, and a greater number of midwives' clients breastfed their infants. However, the interpretation of these results must take into account that the two groups had different personal expectations and values with regard to health and health care. These findings are enlightening in evaluating women's needs, expectations, and satisfaction with health care services and should be included in future development of maternity care, including idwifery services, in Québec and other locations.
NASA Astrophysics Data System (ADS)
Kim, Yeong E.; Koltick, David S.; Reifenberger, Ronald G.; Zubarev, Alexander L.
2006-02-01
Most of experimental results of low-energy nuclear reaction (LENR) reported so far cannot be reproduced on demand. There have been persistent experimental results indicating that the LENR and transmutation processes in condensed matters (LENRTPCM) are surface phenomena rather than bulk phenomena. Recently proposed Bose-Einstein condensation (BEC) mechanism may provide a suitable theoretical description of the surface phenomena. New experiments are proposed and described for testing the BEC mechanism for LENR and transmutation processes in micro- and nano-scale traps. (1) We propose the use of micro- or nano-porous conducting materials as a cathode in electrolysis experiments with heavy water with or without Li in order to stabilize the active surface spots and to enhance the effect for the purpose of improving the reproducibility of excess heat generation and nuclear emission. (2) We propose new experimental tests of the BEC mechanism by measuring the pressure and temperature dependence of LENR events using deuterium gas and these deuterated metals with or without Li. If the LENRTPCM are surface phenomena, the proposed use of micro-/nano-scale porous materials is expected to enhance and scale up the LENRTPCM effects by many order of magnitude, and thus may lead to better reproductivity and theoretical understanding of the phenomena.
Chen, Qijin
2016-01-01
BCS–Bose-Einstein condensation (BEC) crossover is effected by increasing pairing strength between fermions from weak to strong in the particle-particle channel, and has attracted a lot of attention since the experimental realization of quantum degenerate atomic Fermi gases. Here we study the effect of the (often dropped) particle-hole channel on the zero T gap Δ(0), superfluid transition temperature Tc, the pseudogap at Tc, and the mean-field ratio 2Δ(0)/, from BCS through BEC regimes, using a pairing fluctuation theory which includes self-consistently the contributions of finite-momentum pairs and features a pseudogap in single particle excitation spectrum. Summing over the infinite particle-hole ladder diagrams, we find a complex dynamical structure for the particle-hole susceptibility χph, and conclude that neglecting the self-energy feedback causes a serious over-estimate of χph. While our result in the BCS limit agrees with Gor’kov et al., the particle-hole channel effect becomes more complex and pronounced in the crossover regime, where χph is reduced by both a smaller Fermi surface and a big (pseudo)gap. Deep in the BEC regime, the particle-hole channel contributions drop to zero. We predict a density dependence of the magnetic field at the Feshbach resonance, which can be used to quantify χph and test different theories. PMID:27183875
Dukes, Thomas W.; Labonté, Bertrand
1991-01-01
Quarantine, as a means of preventing disease importation, has been used for people and animals since the mid-19th century in Canada. The first animal quarantine facility in North America was established at Lévis, Québec in 1876. This quarantine station existed at Lévis until 1982 when it was closed and the function moved to Mirabel, Québec, near the International Airport. Veterinarians were in charge during the life of the Lévis Quarantine Station and some were also in charge of the Port of Quebec or a nearby District Office prior to the 1950's. In 1884 and 1886 the value of such a facility was illustrated in preventing the entry into Canada of contagious bovine pleuropneumonia and a vesicular disease. It was described in 1933 as “undoubtedly our most important quarantine station” and a year's operating costs as “trifling in comparison to losses which could occur if a foreign plague invaded this country”. This facility's history also illustrated the close veterinary and human medical cooperation during the early days of organized veterinary medicine in Canada. The station was an example for the establishment of other such facilities in North America. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6. PMID:17423811
Maziade, M; Gingras, N; Rouleau, N; Poulin, S; Jomphe, V; Paradis, M-E; Mérette, C; Roy, M-A
2008-02-01
The follow-up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of a BP parent (HRBP) who had an extremely loaded family history. The sample (average age of 17.5, SD 4.5) consisted of 54 high-risk offspring (HR) having one parent affected by a DSM-IV SZ or BP. The parents descended from 21 multigenerational families that constitute a quasi-total sample of such kindred in eastern Québec. The HRs were administered a lifetime best estimate DSM-IV diagnosis. We observed that the rates, the diversity of diagnoses, the high comorbidity, the severity and the age of onset of the clinical diagnoses tended to be similar with those already reported in the offspring of affected parents with a low familial loading. Although the sample size was small, HRSZ and HRBP also tended to show similarities in their clinical status. Overall, taking into account methodological limitations, the observation early in life of some shared characteristics among HRSZ and HRBP in terms of non-psychotic diagnosis may be congruent with the accumulating evidence that several phenotypic features are shared in adulthood by the two major psychoses.
A three-layer magnetic shielding for the MAIUS-1 mission on a sounding rocket
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kubelka-Lange, André, E-mail: andre.kubelka@zarm.uni-bremen.de; Herrmann, Sven; Grosse, Jens
Bose-Einstein-Condensates (BECs) can be used as a very sensitive tool for experiments on fundamental questions in physics like testing the equivalence principle using matter wave interferometry. Since the sensitivity of these experiments in ground-based environments is limited by the available free fall time, the QUANTUS project started to perform BEC interferometry experiments in micro-gravity. After successful campaigns in the drop tower, the next step is a space-borne experiment. The MAIUS-mission will be an atom-optical experiment that will show the feasibility of experiments with ultra-cold quantum gases in microgravity in a sounding rocket. The experiment will create a BEC of 10{supmore » 5} {sup 87}Rb-atoms in less than 5 s and will demonstrate application of basic atom interferometer techniques over a flight time of 6 min. The hardware is specifically designed to match the requirements of a sounding rocket mission. Special attention is thereby spent on the appropriate magnetic shielding from varying magnetic fields during the rocket flight, since the experiment procedures are very sensitive to external magnetic fields. A three-layer magnetic shielding provides a high shielding effectiveness factor of at least 1000 for an undisturbed operation of the experiment. The design of this magnetic shielding, the magnetic properties, simulations, and tests of its suitability for a sounding rocket flight are presented in this article.« less
A three-layer magnetic shielding for the MAIUS-1 mission on a sounding rocket.
Kubelka-Lange, André; Herrmann, Sven; Grosse, Jens; Lämmerzahl, Claus; Rasel, Ernst M; Braxmaier, Claus
2016-06-01
Bose-Einstein-Condensates (BECs) can be used as a very sensitive tool for experiments on fundamental questions in physics like testing the equivalence principle using matter wave interferometry. Since the sensitivity of these experiments in ground-based environments is limited by the available free fall time, the QUANTUS project started to perform BEC interferometry experiments in micro-gravity. After successful campaigns in the drop tower, the next step is a space-borne experiment. The MAIUS-mission will be an atom-optical experiment that will show the feasibility of experiments with ultra-cold quantum gases in microgravity in a sounding rocket. The experiment will create a BEC of 10(5) (87)Rb-atoms in less than 5 s and will demonstrate application of basic atom interferometer techniques over a flight time of 6 min. The hardware is specifically designed to match the requirements of a sounding rocket mission. Special attention is thereby spent on the appropriate magnetic shielding from varying magnetic fields during the rocket flight, since the experiment procedures are very sensitive to external magnetic fields. A three-layer magnetic shielding provides a high shielding effectiveness factor of at least 1000 for an undisturbed operation of the experiment. The design of this magnetic shielding, the magnetic properties, simulations, and tests of its suitability for a sounding rocket flight are presented in this article.
Ten years of integrated care: backwards and forwards. The case of the province of Québec, Canada
Vedel, Isabelle; Monette, Michele; Beland, François; Monette, Johanne; Bergman, Howard
2011-01-01
Introduction Québec’s rapidly growing elderly and chronically ill population represents a major challenge to its healthcare delivery system, attributable in part to the system’s focus on acute care and fragmented delivery. Description of policy practice Over the past few years, reforms have been implemented at the provincial policy level to integrate hospital-based, nursing home, homecare and social services in 95 catchment areas. Recent organizational changes in primary care have also resulted in the implementation of family medicine groups and network clinics. Several localized initiatives were also developed to improve integration of care for older persons or persons with chronic diseases. Conclusion and discussion Québec has a history of integration of health and social services at the structural level. Recent evaluations of the current reform show that the care provided by various institutions in the healthcare system is becoming better integrated. The Québec health care system nevertheless continues to face three important challenges in its management of chronic diseases: implementing the reorganization of primary care, successfully integrating primary and secondary care at the clinical level, and developing effective governance and change management. Efforts should focus on strengthening primary care by implementing nurse practitioners, developing a shared information system, and achieving better collaboration between primary and secondary care. PMID:21677842
Conradson, Steven D.; Gilbertson, Steven M.; Daifuku, Stephanie L.; ...
2015-10-16
Bose-Einstein condensates (BECs) composed of polarons would be an advance because they would combine coherently charge, spin, and a crystal lattice. Following our earlier report of unique structural and spectroscopic properties, we now identify potentially definitive evidence for polaronic BECs in photo- and chemically doped UO 2(+x) on the basis of exceptional coherence in the ultrafast time dependent terahertz absorption and microwave spectroscopy results that show collective behavior including dissipation patterns whose precedents are condensate vortex and defect disorder and condensate excitations. Furthermore, that some of these signatures of coherence in an atom-based system extend to ambient temperature suggests amore » novel mechanism that could be a synchronized, dynamical, disproportionation excitation, possibly via the solid state analog of a Feshbach resonance that promotes the coherence. Such a mechanism would demonstrate that the use of ultra-low temperatures to establish the BEC energy distribution is a convenience rather than a necessity, with the actual requirement for the particles being in the same state that is not necessarily the ground state attainable by other means. Interestingly, a macroscopic quantum object created by chemical doping that can persist to ambient temperature and resides in a bulk solid would be revolutionary in a number of scientific and technological fields.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Conradson, Steven D.; Gilbertson, Steven M.; Daifuku, Stephanie L.
Bose-Einstein condensates (BECs) composed of polarons would be an advance because they would combine coherently charge, spin, and a crystal lattice. Following our earlier report of unique structural and spectroscopic properties, we now identify potentially definitive evidence for polaronic BECs in photo- and chemically doped UO 2(+x) on the basis of exceptional coherence in the ultrafast time dependent terahertz absorption and microwave spectroscopy results that show collective behavior including dissipation patterns whose precedents are condensate vortex and defect disorder and condensate excitations. Furthermore, that some of these signatures of coherence in an atom-based system extend to ambient temperature suggests amore » novel mechanism that could be a synchronized, dynamical, disproportionation excitation, possibly via the solid state analog of a Feshbach resonance that promotes the coherence. Such a mechanism would demonstrate that the use of ultra-low temperatures to establish the BEC energy distribution is a convenience rather than a necessity, with the actual requirement for the particles being in the same state that is not necessarily the ground state attainable by other means. Interestingly, a macroscopic quantum object created by chemical doping that can persist to ambient temperature and resides in a bulk solid would be revolutionary in a number of scientific and technological fields.« less
Messing, Karen
2017-11-01
The University of Québec in Montréal has agreements with trade unions providing access to university resources. Researchers involved in this program worked in partnership with union women's and health and safety committees for more than twenty years. Not all studies succeeded in improving women's working conditions. One joint project involved observational studies of tasks done by health-care workers, complemented by interviews and questionnaires. We found that task assignments, movements, postures, and work-related musculoskeletal disorders varied by gender/sex and made recommendations for change. However, issues of pay equity, spending on health care, and contracting-out of "ancillary work" were salient. Researchers learned that in the absence of changes in power relationships in the workplace, women may be disadvantaged by denial as well as by exaggeration of female-male differences. Men may also be at risk when their gender is invisible. We suggest some feminist approaches to workplace solutions and some pathways for research. Résumé L'Université du Québec à Montréal a signé avec des centrales syndicales des ententes leur donnant un accès à des ressources universitaires. Des chercheures ont travaillé en partenariat avec des comités syndicaux de condition des femmes et de santé-sécurité au travail pendant plus de 25 ans, mais ce ne sont pas toutes les études qui ont abouti à des améliorations. Un projet concernait des observations du travail d'employé.e.s du secteur de la santé, dont les tâches, mouvements, et postures variaient selon le genre/sexe. Nous avons recommandé des transformations, mais des enjeux d'équité salariale, de coûts et de sous-traitance y ont fait obstacle. Les chercheures ont appris qu'en l'absence de transformation des rapports de pouvoir au travail, le déni des différences hommes-femmes, autant que leur exagération, peut désavantager les travailleuses (et les travailleurs). Nous suggérons des approches féministes aux solutions pour le milieu de travail, ainsi que des pistes de recherche.
ERIC Educational Resources Information Center
Käyhkö, Mari
2015-01-01
In Finland, the financial status of a family does not in general place any restrictions on a person's studies. However, in spite of equality of opportunity, class as a cultural and social issue is a significant factor guiding the education of young people. In the article, I analyse women with a working-class background studying at university,…
Commonwealth Degrees from Class to Equivalence: Changing to Grade Point Averages in the Caribbean
ERIC Educational Resources Information Center
Bastick, Tony
2004-01-01
British Commonwealth universities inherited the class system for classifying degrees. However, increasing global marketization has brought with it increasing demands for student exchanges, particularly with universities in North America. Hence, Commonwealth universities are considering adopting grade point averages (GPAs) for degree classification…
The Compressed Video Experience.
ERIC Educational Resources Information Center
Weber, John
In the fall semester 1995, Southern Arkansas University- Magnolia (SAU-M) began a two semester trial delivering college classes via a compressed video link between SAU-M and its sister school Southern Arkansas University Tech (SAU-T) in Camden. As soon as the University began broadcasting and receiving classes, it was discovered that using the…
ERIC Educational Resources Information Center
McBride, Ron E.; Xiang, Ping
2013-01-01
Three hundred and sixty-one students participating in university physical activity classes completed questionnaires assessing perceived health and self-regulated learning. In addition, 20 students (11 men; 9 women) were interviewed about their reasons for enrolling, participation and goals in the class. Results indicated the students endorsed…
ERIC Educational Resources Information Center
McBride, Ron E.; Altunsöz, Irmak Hürmeriç; Su, Xiaoxia; Xiang, Ping; Demirhan, Giyasettin
2016-01-01
The purpose of this study was to explore motivational indicators of self-regulated learning (SRL) and the relationship between self-regulation (SR) and perceived health among university students enrolled in physical activity (PA) classes. One hundred thirty-one Turkish students participating in physical education activity classes at two…
Challenges in Understanding Photosynthesis in a University Introductory Biosciences Class
ERIC Educational Resources Information Center
Södervik, Ilona; Virtanen, Viivi; Mikkilä-Erdmann, Mirjamaija
2015-01-01
University students' understanding of photosynthesis was examined in a large introductory biosciences class. The focus of this study was to first examine the conceptions of photosynthesis among students in class and then to investigate how a certain type of text could enhance students' understanding of photosynthesis. The study was based on pre-…
ERIC Educational Resources Information Center
Yilmaz, Idris
2013-01-01
The present study aims to identify pre-service physical education teachers' class management profiles, teachers' self-efficacy and the relationship between their class management profiles and teacher self-efficacy beliefs. The universe comprised junior and senior students studying physical education teaching at six different universities (Ahi…
Teaching Large Sections of a Business Communication Course: A Multicase Study
ERIC Educational Resources Information Center
Wright, Carol
2017-01-01
The purpose of this research is to examine specific examples of how business communication courses are delivered in large, face-to-face university classes to discover implications of these large courses. This case study reviewed four classes from two different midsized universities whose classes range from 48 to 300 students. Findings suggest…
Sun, Wen-Rong; Wang, Lei
2018-01-01
To show the existence and properties of matter rogue waves in an F =1 spinor Bose-Einstein condensate (BEC), we work on the three-component Gross-Pitaevskii (GP) equations. Via the Darboux-dressing transformation, we obtain a family of rational solutions describing the extreme events, i.e. rogue waves. This family of solutions includes bright-dark-bright and bright-bright-bright rogue waves. The algebraic construction depends on Lax matrices and their Jordan form. The conditions for the existence of rogue wave solutions in an F =1 spinor BEC are discussed. For the three-component GP equations, if there is modulation instability, it is of baseband type only, confirming our analytic conditions. The energy transfers between the waves are discussed.
Josephson effects in a Bose–Einstein condensate of magnons
DOE Office of Scientific and Technical Information (OSTI.GOV)
Troncoso, Roberto E., E-mail: r.troncoso.c@gmail.com; Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Casilla 487-3, Santiago; Núñez, Álvaro S., E-mail: alnunez@dfi.uchile.cl
A phenomenological theory is developed, that accounts for the collective dynamics of a Bose–Einstein condensate of magnons. In terms of such description we discuss the nature of spontaneous macroscopic interference between magnon clouds, highlighting the close relation between such effects and the well known Josephson effects. Using those ideas, we present a detailed calculation of the Josephson oscillations between two magnon clouds, spatially separated in a magnonic Josephson junction. -- Highlights: •We presented a theory that accounts for the collective dynamics of a magnon-BEC. •We discuss the nature of macroscopic interference between magnon-BEC clouds. •We remarked the close relation betweenmore » the above phenomena and Josephson’s effect. •We remark the distinctive oscillations that characterize the Josephson oscillations.« less
Scattering length of composite bosons in the three-dimensional BCS-BEC crossover
NASA Astrophysics Data System (ADS)
Salasnich, L.; Bighin, G.
2015-03-01
We study the zero-temperature grand potential of a three-dimensional superfluid made of ultracold fermionic alkali-metal atoms in the BCS-BEC crossover. In particular, we analyze the zero-point energy of both fermionic single-particle excitations and bosonic collective excitations. The bosonic elementary excitations, which are crucial to obtain a reliable equation of state in the Bose-Einstein condensate regime, are obtained with a low-momentum expansion up to the forth order of the quadratic (Gaussian) action of the fluctuating pairing field. By performing a cutoff regularization and renormalization of Gaussian fluctuations, we find that the scattering length aB of composite bosons, bound states of fermionic pairs, is given by aB=(2 /3 ) aF , where aF is the scattering length of fermions.
NASA Astrophysics Data System (ADS)
Sun, Wen-Rong; Wang, Lei
2018-01-01
To show the existence and properties of matter rogue waves in an F=1 spinor Bose-Einstein condensate (BEC), we work on the three-component Gross-Pitaevskii (GP) equations. Via the Darboux-dressing transformation, we obtain a family of rational solutions describing the extreme events, i.e. rogue waves. This family of solutions includes bright-dark-bright and bright-bright-bright rogue waves. The algebraic construction depends on Lax matrices and their Jordan form. The conditions for the existence of rogue wave solutions in an F=1 spinor BEC are discussed. For the three-component GP equations, if there is modulation instability, it is of baseband type only, confirming our analytic conditions. The energy transfers between the waves are discussed.
Horizon in Random Matrix Theory, the Hawking Radiation, and Flow of Cold Atoms
DOE Office of Scientific and Technical Information (OSTI.GOV)
Franchini, Fabio; Kravtsov, Vladimir E.
2009-10-16
We propose a Gaussian scalar field theory in a curved 2D metric with an event horizon as the low-energy effective theory for a weakly confined, invariant random matrix ensemble (RME). The presence of an event horizon naturally generates a bath of Hawking radiation, which introduces a finite temperature in the model in a nontrivial way. A similar mapping with a gravitational analogue model has been constructed for a Bose-Einstein condensate (BEC) pushed to flow at a velocity higher than its speed of sound, with Hawking radiation as sound waves propagating over the cold atoms. Our work suggests a threefold connectionmore » between a moving BEC system, black-hole physics and unconventional RMEs with possible experimental applications.« less
Chladni solitons and the onset of the snaking instability for dark solitons in confined superfluids.
Muñoz Mateo, A; Brand, J
2014-12-19
Complex solitary waves composed of intersecting vortex lines are predicted in a channeled superfluid. Their shapes in a cylindrical trap include a cross, spoke wheels, and Greek Φ, and trace the nodal lines of unstable vibration modes of a planar dark soliton in analogy to Chladni's figures of membrane vibrations. The stationary solitary waves extend a family of solutions that include the previously known solitonic vortex and vortex rings. Their bifurcation points from the dark soliton indicating the onset of new unstable modes of the snaking instability are predicted from scale separation for Bose-Einstein condensates (BECs) and superfluid Fermi gases across the BEC-BCS crossover, and confirmed by full numerical calculations. Chladni solitons could be observed in ultracold gas experiments by seeded decay of dark solitons.
Aging experiences of older immigrant women in Québec (Canada): From deskilling to liberation.
Charpentier, Michèle; Quéniart, Anne
2017-01-01
This article examines experiences of aging of older immigrant women. The data are based on qualitative research that was conducted in Québec, Canada with 83 elderly women from different ethnocultural backgrounds (Arab, African, Haitian, Japanese, Chinese, Portuguese, Romanian, etc.). The results on how such immigrant women deal with material conditions of existence such as deskilling, aging alone, being more economically independent, and the combined effects of liberation from social and family norms associated with age and gender in the light of the migration route, will be presented. For the majority, migration opened up possibilities for personal development and self-affirmation. The findings demonstrated the relevance of the intersectional approach in understanding the complexity and social conditionings of women's experiences of aging.
Magic tilt angle for stabilizing two-dimensional solitons by dipole-dipole interactions
NASA Astrophysics Data System (ADS)
Chen, Xing-You; Chuang, You-Lin; Lin, Chun-Yan; Wu, Chien-Ming; Li, Yongyao; Malomed, Boris A.; Lee, Ray-Kuang
2017-10-01
In the framework of the Gross-Pitaevskii equation, we study the formation and stability of effectively two-dimensional solitons in dipolar Bose-Einstein condensates (BECs), with dipole moments polarized at an arbitrary angle θ relative to the direction normal to the system's plane. Using numerical methods and the variational approximation, we demonstrate that unstable Townes solitons, created by the contact attractive interaction, may be completely stabilized (with an anisotropic shape) by the dipole-dipole interaction (DDI), in the interval θcr<θ ≤π /2 . The stability boundary θcr weakly depends on the relative strength of the DDI, remaining close to the magic angle θm=arccos(1 /√{3 }) . The results suggest that DDIs provide a generic mechanism for the creation of stable BEC solitons in higher dimensions.
Chladni Solitons and the Onset of the Snaking Instability for Dark Solitons in Confined Superfluids
NASA Astrophysics Data System (ADS)
Muñoz Mateo, A.; Brand, J.
2014-12-01
Complex solitary waves composed of intersecting vortex lines are predicted in a channeled superfluid. Their shapes in a cylindrical trap include a cross, spoke wheels, and Greek Φ , and trace the nodal lines of unstable vibration modes of a planar dark soliton in analogy to Chladni's figures of membrane vibrations. The stationary solitary waves extend a family of solutions that include the previously known solitonic vortex and vortex rings. Their bifurcation points from the dark soliton indicating the onset of new unstable modes of the snaking instability are predicted from scale separation for Bose-Einstein condensates (BECs) and superfluid Fermi gases across the BEC-BCS crossover, and confirmed by full numerical calculations. Chladni solitons could be observed in ultracold gas experiments by seeded decay of dark solitons.
NASA Astrophysics Data System (ADS)
Park, Su-Chan
2017-09-01
The one-dimensional pair contact process with diffusion (PCPD), an interacting particle system with diffusion, pair annihilation, and creation by pairs, has defied consensus about the universality class to which it belongs. An argument by Hinrichsen [Physica A 361, 457 (2006), 10.1016/j.physa.2005.06.101] claims that freely diffusing particles in the PCPD should play the same role as frozen particles when it comes to the critical behavior. Therefore, the PCPD is claimed to have the same critical phenomena as a model with infinitely many absorbing states that belongs to the directed percolation (DP) universality class. To investigate if diffusing particles are really indistinguishable from frozen particles in the sense of the renormalization group, we study numerically a variation of the PCPD by introducing a nonorder field associated with infinitely many absorbing states. We find that a crossover from the PCPD to DP occurs due to the nonorder field. By studying a similar model, we exclude the possibility that the mere introduction of a nonorder field to one model can entail a nontrivial crossover to another model in the same universality class, thus we attribute the observed crossover to the difference of the universality class of the PCPD from the DP class.
ERIC Educational Resources Information Center
Tian, Mei; Lu, Genshu
2017-01-01
This study explores the challenges faced by young lecturers in managerial transformation in elite Chinese academic institutions which aim to develop into world-class universities. Drawing on data from in-depth interviews, the paper discusses how a group of lecturers on tenure-track contracts at a research university in China perceived the impacts…
NASA Astrophysics Data System (ADS)
Hoefer, Mark A.
This thesis examines nonlinear wave phenomena, in two physical systems: a Bose-Einstein condensate (BEC) and thin film ferromagnets where the magnetization dynamics are excited by the spin momentum transfer (SMT) effect. In the first system, shock waves generated by steep gradients in the BEC wavefunction are shown to be of the disperse type. Asymptotic and averaging methods are used to determine shock speeds and structure in one spatial dimension. These results are compared with multidimensional numerical simulations and experiment showing good, qualitative agreement. In the second system, a model of magnetization dynamics due to SMT is presented. Using this model, nonlinear oscillating modes---nano-oscillators---are found numerically and analytically using perturbative methods. These results compare well with experiment. A Bose-Einstein condensate (BEC) is a quantum fluid that gives rise to interesting shock wave nonlinear dynamics. Experiments depict a BEC that exhibits behavior similar to that of a shock wave in a compressible gas, e.g. traveling fronts with steep gradients. However, the governing Gross-Pitaevskii (GP) equation that describes the mean field of a BEC admits no dissipation hence classical dissipative shock solutions do not explain the phenomena. Instead, wave dynamics with small dispersion is considered and it is shown that this provides a mechanism for the generation of a dispersive shock wave (DSW). Computations with the GP equation are compared to experiment with excellent agreement. A comparison between a canonical 1D dissipative and dispersive shock problem shows significant differences in shock structure and shock front speed. Numerical results associated with laboratory experiments show that three and two-dimensional approximations are in excellent agreement and one dimensional approximations are in qualitative agreement. The interaction of two DSWs is investigated analytically and numerically. Using one dimensional DSW theory it is argued that the experimentally observed blast waves may be viewed as dispersive shock waves. A nonlinear mathematical model of spin-wave excitation using a point contact in a thin ferromagnetic film is introduced. This work incorporates a recently proposed spin-torque contribution to classical magnetodynamic theory with a variable coefficient terra in the magnetic torque equation. Large-amplitude magnetic solitary waves are computed, which help explain recent spin-torque experiments. Numerical simulations of the full nonlinear model predict excitation frequencies in excess of 0.2 THz for contact diameters smaller than 6 nm. Simulations also predict a saturation and red shift of the frequency at currents large enough to invert the magnetization tinder the point contact. In the weak nonlinear limit, the theory is approximated by a cubic complex Ginzburg-Landau type equation. The mode's nonlinear frequency shift is found by use of perturbation techniques, whose results agree with those of direct numerical simulations.
Matson, Liana; Liangpunsakul, Suthat; Crabb, David; Buckingham, Amy; Ross, Ruth Ann; Halcomb, Meredith; Grahame, Nicholas
2013-02-01
Crossed high alcohol preferring (cHAP) mice were selectively bred from a cross of the HAP1 × HAP2 replicate lines, and we demonstrate blood ethanol concentrations (BECs) during free-choice drinking that are reminiscent of those observed in alcohol-dependent humans. Therefore, this line may provide an unprecedented opportunity to learn about the consequences of excessive voluntary ethanol (EtOH) consumption, including metabolic tolerance and liver pathology. Cytochrome p450 2E1 (CYP2E1) induction plays a prominent role in driving both metabolic tolerance and EtOH-induced liver injury. In this report, we sought to characterize cHAP drinking by assessing whether pharmacologically relevant BEC levels are sustained throughout the active portion of the light-dark cycle. Given that cHAP intakes and BECs are similar to those observed in mice given an EtOH liquid diet, we assessed whether free-choice exposure results in metabolic tolerance, hepatic enzyme induction, and hepatic steatosis. In experiment 1, blood samples were taken across the dark portion of a 12:12 light-dark cycle to examine the pattern of EtOH accumulation in these mice. In experiments 1 and 2, mice were injected with EtOH following 3 to 4 weeks of access to water or 10% EtOH and water, and blood samples were taken to assess metabolic tolerance. In experiment 3, 24 mice had 4 weeks of access to 10% EtOH and water or water alone, followed by necropsy and hepatological assessment. In experiment 1, cHAP mice mean BEC values exceeded 80 mg/dl at all sampling points and approached 200 mg/dl during the middle of the dark cycle. In experiments 1 and 2, EtOH-exposed mice metabolized EtOH faster than EtOH-naïve mice, demonstrating metabolic tolerance (p < 0.05). In experiment 3, EtOH-drinking mice showed greater expression of hepatic CYP2E1 than water controls, consistent with the development of metabolic tolerance (p < 0.05). EtOH access altered neither hepatic histology nor levels of alcohol dehydrogenase and aldehyde dehydrogenase. These results demonstrate that excessive intake by cHAP mice results in sustained BECs throughout the active period, leading to the development of metabolic tolerance and evidence of CYP2E1 induction. Together, these results provide additional support for the cHAP mice as a highly translational rodent model of alcoholism. Copyright © 2012 by the Research Society on Alcoholism.
ERIC Educational Resources Information Center
Gibson, Jane Whitney
2008-01-01
The author taught three MBA Human Resource Management classes in the spring term of 2007 at a large private university in Florida. Two of the classes were taught in a 100% online format while the third was taught off campus in a university-owned building in Orlando where students met in a face-to-face, weekend setting. This traditional class was…
A person-centered approach to individualizing a school-based universal preventive intervention.
Caldwell, Linda L; Bradley, Stephanie; Coffman, Donna
2009-01-01
This manuscript focuses on how individualized components may be embedded within a universal preventive intervention (TimeWise: Taking Charge of Leisure Time) to make program delivery more effective. Leisure related variables (motivation, boredom/interest and peer and parental influence) were used to suggest ways to individualize the program. Latent Class Analysis was used to develop individualized risk and strength profiles of adolescents (N = 617). Comparisons were made between a treatment and control group. Four classes were identified: undifferentiated high, intrinsic motivation, extrinsic motivation/amotivation, undifferentiated low. These classes were related to substance use. Membership in the intrinsic class was associated with intervention group while the extrinsic class was related to the control group. Results were useful in suggesting ways to tailor a universal prevention program.
The ethnic roots of class universalism: rethinking the "Russian" revolutionary elite.
Riga, Liliana
2008-11-01
This article retrieves the ethnic roots that underlie a universalist class ideology. Focusing empirically on the emergence of Bolshevism, it provides biographical analysis of the Russian Revolution's elite, finding that two-thirds were ethnic minorities from across the Russian Empire. After exploring class and ethnicity as intersectional experiences of varying significance to the Bolsheviks' revolutionary politics, this article suggests that socialism's class universalism found affinity with those seeking secularism in response to religious tensions, a universalist politics where ethnic violence and sectarianism were exclusionary, and an ethnically neutral and tolerant "imperial" imaginary where Russification and geopolitics were particularly threatening or imperial cultural frameworks predominated. The claim is made that socialism's class universalism was as much a product of ethnic particularism as it was constituted by it.
Reaching the Students: A New Approach to Enhancing Science Literacy
NASA Astrophysics Data System (ADS)
McNamara, B. J.; Burnham, C. C.
2002-05-01
Most NSF supported programs directed at improving science literacy among university students who are not majoring in SMET normally target instruction in introductory science or math classes. Unfortunately these efforts seldom reach the vast majority of students at a university because students can fulfil their science requirement by taking several other classes or class sections that are not impacted by the NSF program. Ideally it would be desirable to address the issues of science literacy and science anxiety among non-science majors in a single class that is required of essentially all undergraduates. We describe such a program which is being tested at NMSU. The targeted class is the university's freshman level English class. The idea behind this effort is to provide students with the skills they will need to be successful in their science classes in a less threatening humanities environment. We describe the problems that this approach raises, suggest solutions to these problems, and then discuss the overall status of this effort.
Exploring University Teacher Perceptions about Out-of-Class Teamwork
ERIC Educational Resources Information Center
Ruiz-Esparza Barajas, Elizabeth; Medrano Vela, Cecilia Araceli; Zepeda Huerta, Jesús Helbert Karim
2016-01-01
This study reports on the first stage of a larger joint research project undertaken by five universities in Mexico to explore university teachers' thinking about out-of-class teamwork. Data from interviews were analyzed using open and axial coding. Although results suggest a positive perception towards teamwork, the study unveiled important…
World-Class Higher Education and the Emerging Chinese Model of the University
ERIC Educational Resources Information Center
Li, Jun
2012-01-01
China's recent quest to develop world-class universities is a significant phenomenon within the worldwide transformation of tertiary education. Taking a cultural approach and drawing on empirical findings, this article investigates the emerging Chinese model of the university, considering its key features and contributions to global communities.…
Perceptions of University Assessment and Feedback among Post-16 School Pupils
ERIC Educational Resources Information Center
Jones, Harriet; Yeoman, Kay; Gaskell, Emma; Prendergast, John
2017-01-01
The transition between school and university can be problematic for students. Understanding students' expectations about the system they are entering is crucial in effecting a smooth transition. The school system involves small classes, often with teachers who know their students well. In contrast, university involves large class sizes and a…
Inverted Teaching: Applying a New Pedagogy to a University Organic Chemistry Class
ERIC Educational Resources Information Center
Christiansen, Michael A.
2014-01-01
Inverted teaching, not to be confused with hybrid learning, is a relatively new pedagogy in which lecture is shifted outside of class and traditional homework is done in class. Though some inverted teaching (IT) designs have been published in different fields, peer-reviewed reports in university chemistry remain quite rare. To that end, herein is…
The Hurdles to Being World Class: Narrative Analysis of the World-Class University Project in Korea
ERIC Educational Resources Information Center
Jang, Deok-Ho; Ryu, Kiung; Yi, Pilnam; Craig, Daniel A.
2016-01-01
This study examines the Korean Government's policy scheme of setting up the World-Class University (WCU) Project by investigating the perceptions of major actors, including WCU scholars and government officials. In-depth interviews were held with 18 WCU scholars and three government officials. Our findings suggest that the limits of the…
ERIC Educational Resources Information Center
Crozier, Gill; Reay, Diane; Clayton, John; Colliander, Lori; Grinstead, Jan
2008-01-01
In the context of widening participation policies, polarisation of types of university recruitment and a seemingly related high drop-out rate amongst first generation, working class students, we focus on the provision offered by the universities to their students. We discuss how middle class and working class student experiences compare across…
Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice.
Rhodes, Justin S; Best, Karyn; Belknap, John K; Finn, Deborah A; Crabbe, John C
2005-01-31
Because of intrinsic differences between humans and mice, no single mouse model can represent all features of a complex human trait such as alcoholism. It is therefore necessary to develop partial models. One important feature is drinking to the point where blood ethanol concentration (BEC) reaches levels that have measurable affects on physiology and/or behavior (>1.0 mg ethanol/ml blood). Most models currently in use examine relative oral self-administration from a bottle containing alcohol versus one containing water (two-bottle preference drinking), or oral operant self-administration. In these procedures, it is not clear when or if the animals drink to pharmacologically significant levels because the drinking is episodic and often occurs over a 24-h period. The aim of this study was to identify the optimal parameters and evaluate the reliability of a very simple procedure, taking advantage of a mouse genotype (C57BL/6J) that is known to drink large quantities of ethanol. We exchanged for the water bottle a solution containing ethanol in tap water for a limited period, early in the dark cycle, in the home cage. Mice regularly drank sufficient ethanol to achieve BEC>1.0 mg ethanol/ml blood. The concentration of ethanol offered (10%, 20% or 30%) did not affect consumption in g ethanol/kg body weight. The highest average BEC ( approximately 1.6 mg/ml) occurred when the water-to-ethanol switch occurred 3 h into the dark cycle, and when the ethanol was offered for 4 rather than 2 h. Ethanol consumption was consistent within individual mice, and reliably predicted BEC after the period of ethanol access. C57BL/6J mice from three sources provided equivalent data, while DBA/2J mice drank much less than C57BL/6J in this test. We discuss advantages of the model for high-throughput screening assays where the goal is to find other genotypes of mice that drink excessively, or to screen drugs for their efficacy in blocking excessive drinking.
Spatially indirect excitons in coupled quantum wells
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lai, Chih-Wei Eddy
2004-03-01
Microscopic quantum phenomena such as interference or phase coherence between different quantum states are rarely manifest in macroscopic systems due to a lack of significant correlation between different states. An exciton system is one candidate for observation of possible quantum collective effects. In the dilute limit, excitons in semiconductors behave as bosons and are expected to undergo Bose-Einstein condensation (BEC) at a temperature several orders of magnitude higher than for atomic BEC because of their light mass. Furthermore, well-developed modern semiconductor technologies offer flexible manipulations of an exciton system. Realization of BEC in solid-state systems can thus provide new opportunitiesmore » for macroscopic quantum coherence research. In semiconductor coupled quantum wells (CQW) under across-well static electric field, excitons exist as separately confined electron-hole pairs. These spatially indirect excitons exhibit a radiative recombination time much longer than their thermal relaxation time a unique feature in direct band gap semiconductor based structures. Their mutual repulsive dipole interaction further stabilizes the exciton system at low temperature and screens in-plane disorder more effectively. All these features make indirect excitons in CQW a promising system to search for quantum collective effects. Properties of indirect excitons in CQW have been analyzed and investigated extensively. The experimental results based on time-integrated or time-resolved spatially-resolved photoluminescence (PL) spectroscopy and imaging are reported in two categories. (i) Generic indirect exciton systems: general properties of indirect excitons such as the dependence of exciton energy and lifetime on electric fields and densities were examined. (ii) Quasi-two-dimensional confined exciton systems: highly statistically degenerate exciton systems containing more than tens of thousands of excitons within areas as small as (10 micrometer) 2 were observed. The spatial and energy distributions of optically active excitons were used as thermodynamic quantities to construct a phase diagram of the exciton system, demonstrating the existence of distinct phases. Optical and electrical properties of the CQW sample were examined thoroughly to provide deeper understanding of the formation mechanisms of these cold exciton systems. These insights offer new strategies for producing cold exciton systems, which may lead to opportunities for the realization of BEC in solid-state systems.« less
Cortés-Vieyra, Ricarda; Silva-García, Octavio; Oviedo-Boyso, Javier; Huante-Mendoza, Alejandro; Bravo-Patiño, Alejandro; Valdez-Alarcón, Juan J; Finlay, B Brett; Baizabal-Aguirre, Víctor M
2015-01-01
Glycogen synthase kinase 3 (GSK3) is a constitutively active regulatory enzyme that is important in cancer, diabetes, and cardiovascular, neurodegenerative, and psychiatric diseases. While GSK3α is usually important in neurodegenerative and psychiatric diseases GSK3β is fundamental in the inflammatory response caused by bacterial components. Peptidoglycan (PGN), one of the most abundant cell-wall structures of Gram-positive bacteria, is an important inducer of inflammation. To evaluate whether inhibition of GSK3α and GSK3β activity in bovine endothelial cells (BEC) regulates the expression of the pro-inflammatory cytokine IL-12p40, we treated BEC with SDS-purified PGN from Staphylococcus aureus. We found that PGN triggered a TLR2/PI3K/Akt-dependent phosphorylation of GSK3α at Ser21, GSK3β at Ser9, and NF-κB p65 subunit (p65) at Ser536, and the phosphorylation of GSK3α was consistently higher than that of GSK3β. The expression of IL-12p40 was inhibited in BEC stimulated with PGN and pre-treated with a specific neutralizing anti-TLR2 antibody that targets the extracellular domain of TLR2 or by the addition of Akt-i IV (an Akt inhibitor). Inhibition of GSK3α and GSK3β with LiCl or SB216763 induced an increase in IL-12p40 mRNA and protein. The effect of each isoform on IL-12p40 expression was evaluated by siRNA-gene expression silencing of GSK3α and GSK3β. GSK3α gene silencing resulted in a marked increase in IL-12p40 mRNA and protein while GSK3β gene silencing had the opposite effect on IL-12p40 expression. These results indicate that the TLR2/PI3K/Akt-dependent inhibition of GSK3α activity also plays an important role in the inflammatory response caused by stimulation of BEC with PGN from S. aureus.
An Analysis of a First-Year Class on the Self-Efficacy of University Students in Japan
ERIC Educational Resources Information Center
Shin, Kimie; Nakagami, Masafumi
2015-01-01
This study aimed to examine the effect of the first-year class in Japanese universities on developing students' self-efficacy. An analysis of the class design based on the theory of self-efficacy implies that such courses are primarily intended to develop students' self-efficacy by putting them through enactive mastery experiences. In addition,…
ERIC Educational Resources Information Center
Saul, Jeffery M.; Deardorff, Duane L.; Abbott, David S.; Allain, Rhett J.; Beichner, Robert J.
The Student-Centered Activities for Large Enrollment University Physics (SCALE-UP) project at North Carolina State University (NCSU) is developing a curriculum to promote learning through in-class group activities in introductory physics classes up to 100 students. The authors are currently in Phase II of the project using a specially designed…
Online, Bigger Classes May Be Better Classes
ERIC Educational Resources Information Center
Parry, Marc
2010-01-01
In his work as a professor, Stephen Downes used to feel that he was helping those who least needed it. His students at places like the University of Alberta already had a leg up in life and could afford the tuition. When a colleague suggested they co-teach an online class in learning theory at the University of Manitoba, in 2008, Downes welcomed…
ERIC Educational Resources Information Center
Hoisch, Thomas D.; Bowie, James I.
2010-01-01
In order to guide the formulation of strategies for recruiting undergraduates into the geology program at Northern Arizona University, we surveyed 783 students in introductory geology classes and 23 geology majors in their junior and senior years. Our analysis shows that ~7% of students in the introductory classes are possible candidates for…
ERIC Educational Resources Information Center
Blanco Ramírez, Gerardo
2016-01-01
This article presents an argument for re-reading Jean Baudrillard's ideas considering their potential contribution to the sociology of higher education, particularly in relation to contemporary debates about "world-class" universities. In order to apply Baudrillard's ideas, China's commitment to the development of "world-class"…
Building the World-Class Research Universities: A Case Study of China
ERIC Educational Resources Information Center
Huang, Futao
2015-01-01
The purpose of this study is to analyze how China has strived to develop its world-class research universities and what are distinguishing characteristics of China's efforts to form these universities for the last decades. This study begins with a review of literature and research questions. It then touches on the background and rationale of…
The Visions of World-Class Universities
ERIC Educational Resources Information Center
Slyusarenko, Olena
2015-01-01
The visions of the top 26 world-class universities of the first 30 in the Shanghai ranking list have been evaluated and compared with the missions of the world's top 20 universities. Applying the content analysis, a group of 48 keywords, which describe the essence of these visions, has been revealed. The average amount of keywords in one vision is…
Producing superfluid circulation states using phase imprinting
NASA Astrophysics Data System (ADS)
Kumar, Avinash; Dubessy, Romain; Badr, Thomas; De Rossi, Camilla; de Goër de Herve, Mathieu; Longchambon, Laurent; Perrin, Hélène
2018-04-01
We propose a method to prepare states of given quantized circulation in annular Bose-Einstein condensates (BEC) confined in a ring trap using the method of phase imprinting without relying on a two-photon angular momentum transfer. The desired phase profile is imprinted on the atomic wave function using a short light pulse with a tailored intensity pattern generated with a spatial light modulator. We demonstrate the realization of "helicoidal" intensity profiles suitable for this purpose. Due to the diffraction limit, the theoretical steplike intensity profile is not achievable in practice. We investigate the effect of imprinting an intensity profile smoothed by a finite optical resolution onto the annular BEC with a numerical simulation of the time-dependent Gross-Pitaevskii equation. This allows us to optimize the intensity pattern for a given target circulation to compensate for the limited resolution.
Entanglement and nonlocality in multi-particle systems
NASA Astrophysics Data System (ADS)
Reid, Margaret D.; He, Qiong-Yi; Drummond, Peter D.
2012-02-01
Entanglement, the Einstein-Podolsky-Rosen (EPR) paradox and Bell's failure of local-hiddenvariable (LHV) theories are three historically famous forms of "quantum nonlocality". We give experimental criteria for these three forms of nonlocality in multi-particle systems, with the aim of better understanding the transition from microscopic to macroscopic nonlocality. We examine the nonlocality of N separated spin J systems. First, we obtain multipartite Bell inequalities that address the correlation between spin values measured at each site, and then we review spin squeezing inequalities that address the degree of reduction in the variance of collective spins. The latter have been particularly useful as a tool for investigating entanglement in Bose-Einstein condensates (BEC). We present solutions for two topical quantum states: multi-qubit Greenberger-Horne-Zeilinger (GHZ) states, and the ground state of a two-well BEC.
Zhu, Zengwei; McDonald, R. D.; Shekhter, A.; ...
2017-05-04
Here, the excitonic insulator phase has long been predicted to form in proximity to a band gap opening in the underlying band structure. The character of the pairing is conjectured to crossover from weak (BCS-like) to strong coupling (BEC-like) as the underlying band structure is tuned from the metallic to the insulating side of the gap opening. Here we report the high-magnetic field phase diagram of graphite to exhibit just such a crossover. By way of comprehensive angle-resolved magnetoresistance measurements, we demonstrate that the underlying band gap opening occurs inside the magnetic field-induced phase, paving the way for a systematicmore » study of the BCS-BEC-like crossover by means of conventional condensed matter probes.« less
NASA Astrophysics Data System (ADS)
Levin, Kathryn
2009-05-01
In this talk we summarize our theoretical understanding of the atomic Fermi superfluids with an emphasis on understanding current experiments. We compare and contrast different theoretical approaches for dealing with finite temperature, and discuss their respective implications for these trapped gases. Armed with a basic picture of the thermodynamics we turn to a variety of different measurements based on radio frequency spectroscopy, including both momentum integrated and momentum resolved experiments. As recently reviewed in arXiv 0810.1940 and 0810.1938, we show how a broad range of experimental phenomena can be accomodated within our natural extension of the BCS-Leggett ground state to finite temperature, and briefly touch on the applicability of BCS-BEC crossover theory to the high temperature superconductors. Co-authors: Qijin Chen, Yan He and Chih-Chun Chien
Electrochemical hydrogenation of thiophene on SPE electrodes
NASA Astrophysics Data System (ADS)
Huang, Haiyan; Yuan, Penghui; Yu, Ying; Chung, Keng H.
2017-01-01
Electrochemical reduction desulfurization is a promising technology for petroleum refining which is environmental friendly, low cost and able to achieve a high degree of automation. Electrochemical hydrogenation of thiophene was performed in a three-electrode system which SPE electrode was the working electrode. The electrochemical desulfurization was studied by cyclic voltammetry and bulk electrolysis with coulometry (BEC) techniques. The results of cyclic voltammetry showed that the electrochemical hydrogenation reduction reaction occurred at -0.4V. The BEC results showed that the currents generated from thiophene hydrogenation reactions increased with temperature. According to Arrhenius equation, activation energy of thiophene electrolysis was calculated and lower activation energy value indicated it was diffusion controlled reaction. From the products of electrolytic reactions, the mechanisms of electrochemical hydrogenation of thiophene were proposed, consisting of two pathways: openingring followed by hydrogenation, and hydrogenation followed by ring opening.
NASA Astrophysics Data System (ADS)
Preibus-Norquist, R. N. C.-Grover; Bush-Romney, G. W.-Willard-Mitt; Dimon, J. P.; Adelson-Koch, Sheldon-Charles-David-Sheldon; Krugman-Axelrod, Paul-David; Siegel, Edward Carl-Ludwig; D. N. C./O. F. P./''47''%/50% Collaboration; R. N. C./G. O. P./''53''%/49% Collaboration; Nyt/Wp/Cnn/Msnbc/Pbs/Npr/Ft Collaboration; Ftn/Fnc/Fox/Wsj/Fbn Collaboration; Lb/Jpmc/Bs/Boa/Ml/Wamu/S&P/Fitch/Moodys/Nmis Collaboration
2013-03-01
``Models''? CAVEAT EMPTOR!!!: ``Toy Models Too-Often Yield Toy-Results''!!!: Goldenfeld[``The Role of Models in Physics'', in Lects.on Phase-Transitions & R.-G.(92)-p.32-33!!!]: statistics(Silver{[NYTimes; Bensinger, ``Math-Geerks Clearly-Defeated Pundits'', LATimes, (11/9/12)])}, polls, politics, economics, elections!!!: GRAPH/network/net/...-PHYSICS Barabasi-Albert[RMP (02)] (r,t)-space VERSUS(???) [Where's the Inverse/ Dual/Integral-Transform???] (Benjamin)Franklin(1795)-Fourier(1795; 1897;1822)-Laplace(1850)-Mellin (1902) Brillouin(1922)-...(k,)-space, {Hubbard [The World According to Wavelets,Peters (96)-p.14!!!/p.246: refs.-F2!!!]},and then (2) Albert-Barabasi[]Bose-Einstein quantum-statistics(BEQS) Bose-Einstein CONDENSATION (BEC) versus Bianconi[pvt.-comm.; arXiv:cond-mat/0204506; ...] -Barabasi [???] Fermi-Dirac
NASA Astrophysics Data System (ADS)
Vitali, Ettore; Shi, Hao; Qin, Mingpu; Zhang, Shiwei
2017-12-01
Experiments with ultracold atoms provide a highly controllable laboratory setting with many unique opportunities for precision exploration of quantum many-body phenomena. The nature of such systems, with strong interaction and quantum entanglement, makes reliable theoretical calculations challenging. Especially difficult are excitation and dynamical properties, which are often the most directly relevant to experiment. We carry out exact numerical calculations, by Monte Carlo sampling of imaginary-time propagation of Slater determinants, to compute the pairing gap in the two-dimensional Fermi gas from first principles. Applying state-of-the-art analytic continuation techniques, we obtain the spectral function and the density and spin structure factors providing unique tools to visualize the BEC-BCS crossover. These quantities will allow for a direct comparison with experiments.
Gauss Seidel-type methods for energy states of a multi-component Bose Einstein condensate
NASA Astrophysics Data System (ADS)
Chang, Shu-Ming; Lin, Wen-Wei; Shieh, Shih-Feng
2005-01-01
In this paper, we propose two iterative methods, a Jacobi-type iteration (JI) and a Gauss-Seidel-type iteration (GSI), for the computation of energy states of the time-independent vector Gross-Pitaevskii equation (VGPE) which describes a multi-component Bose-Einstein condensate (BEC). A discretization of the VGPE leads to a nonlinear algebraic eigenvalue problem (NAEP). We prove that the GSI method converges locally and linearly to a solution of the NAEP if and only if the associated minimized energy functional problem has a strictly local minimum. The GSI method can thus be used to compute ground states and positive bound states, as well as the corresponding energies of a multi-component BEC. Numerical experience shows that the GSI converges much faster than JI and converges globally within 10-20 steps.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zhu, Zengwei; McDonald, R. D.; Shekhter, A.
Here, the excitonic insulator phase has long been predicted to form in proximity to a band gap opening in the underlying band structure. The character of the pairing is conjectured to crossover from weak (BCS-like) to strong coupling (BEC-like) as the underlying band structure is tuned from the metallic to the insulating side of the gap opening. Here we report the high-magnetic field phase diagram of graphite to exhibit just such a crossover. By way of comprehensive angle-resolved magnetoresistance measurements, we demonstrate that the underlying band gap opening occurs inside the magnetic field-induced phase, paving the way for a systematicmore » study of the BCS-BEC-like crossover by means of conventional condensed matter probes.« less
Vincent, Caroline; Usongo, Valentine; Berry, Chrystal; Tremblay, Denise M; Moineau, Sylvain; Yousfi, Khadidja; Doualla-Bell, Florence; Fournier, Eric; Nadon, Céline; Goodridge, Lawrence; Bekal, Sadjia
2018-08-01
Salmonella enterica serovar Heidelberg (S. Heidelberg) is one of the top serovars causing human salmonellosis. This serovar ranks second and third among serovars that cause human infections in Québec and Canada, respectively, and has been associated with severe infections. Traditional typing methods such as PFGE do not display adequate discrimination required to resolve outbreak investigations due to the low level of genetic diversity of isolates belonging to this serovar. This study evaluates the ability of four whole genome sequence (WGS)-based typing methods to differentiate among 145 S. Heidelberg strains involved in four distinct outbreak events and sporadic cases of salmonellosis that occurred in Québec between 2007 and 2016. Isolates from all outbreaks were indistinguishable by PFGE. The core genome single nucleotide variant (SNV), core genome multilocus sequence typing (MLST) and whole genome MLST approaches were highly discriminatory and separated outbreak strains into four distinct phylogenetic clusters that were concordant with the epidemiological data. The clustered regularly interspaced short palindromic repeats (CRISPR) typing method was less discriminatory. However, CRISPR typing may be used as a secondary method to differentiate isolates of S. Heidelberg that are genetically similar but epidemiologically unrelated to outbreak events. WGS-based typing methods provide a highly discriminatory alternative to PFGE for the laboratory investigation of foodborne outbreaks. Copyright © 2018 Elsevier Ltd. All rights reserved.
Field-induced superconducting phase of FeSe in the BCS-BEC cross-over
Kasahara, Shigeru; Watashige, Tatsuya; Hanaguri, Tetsuo; Kohsaka, Yuhki; Yamashita, Takuya; Shimoyama, Yusuke; Mizukami, Yuta; Endo, Ryota; Ikeda, Hiroaki; Aoyama, Kazushi; Terashima, Taichi; Uji, Shinya; Wolf, Thomas; von Löhneysen, Hilbert; Shibauchi, Takasada; Matsuda, Yuji
2014-01-01
Fermi systems in the cross-over regime between weakly coupled Bardeen–Cooper–Schrieffer (BCS) and strongly coupled Bose–Einstein-condensate (BEC) limits are among the most fascinating objects to study the behavior of an assembly of strongly interacting particles. The physics of this cross-over has been of considerable interest both in the fields of condensed matter and ultracold atoms. One of the most challenging issues in this regime is the effect of large spin imbalance on a Fermi system under magnetic fields. Although several exotic physical properties have been predicted theoretically, the experimental realization of such an unusual superconducting state has not been achieved so far. Here we show that pure single crystals of superconducting FeSe offer the possibility to enter the previously unexplored realm where the three energies, Fermi energy εF, superconducting gap Δ, and Zeeman energy, become comparable. Through the superfluid response, transport, thermoelectric response, and spectroscopic-imaging scanning tunneling microscopy, we demonstrate that εF of FeSe is extremely small, with the ratio Δ/εF∼1(∼0.3) in the electron (hole) band. Moreover, thermal-conductivity measurements give evidence of a distinct phase line below the upper critical field, where the Zeeman energy becomes comparable to εF and Δ. The observation of this field-induced phase provides insights into previously poorly understood aspects of the highly spin-polarized Fermi liquid in the BCS-BEC cross-over regime. PMID:25378706
Wood, Megan A; Bukowski, William M; Santo, Jonathan B
2017-01-01
A two-wave longitudinal study of 380 preadolescents (M age = 10.87) from largely middle-class schools in Montréal, Québec, Canada, assessed the hypothesis that friendship security, but not friendship intimacy, moderates the stability of anxiety during adolescence. This central but largely overlooked question about peer relations concerns which aspects of friendship account for the effects of friendship on emotional adjustment. Anxiety and friendship quality were measured via self-report questionnaires, employing the Network of Relationships Inventory for security and intimacy items. An index of friendship durability, which combined reciprocity and stability within first- and second-best friendship choices, was derived from sociometric measures. A latent variable path analysis examined with structural equation modeling showed that anxiety was less stable for children who perceived their friendships as secure. The moderating effect of intimacy was statistically nonsignificant. A follow-up analysis showed that the effects of security did not result from friendship durability. These findings provide support for the long-standing but previously unaddressed hypothesis that security, rather than intimacy, accounts for friendship's effect on anxiety reduction during early adolescence.
Kamstra, Rhiannon; Azoulay, Laurent; Steele, Russell; Klein, Marina B; Greenaway, Christina
2016-12-01
Rates of hospitalization due to chronic hepatitis C virus (HCV) are increasing in Canada and the United States. A large proportion of immigrants originate from countries with intermediate to high HCV prevalence but are not screened for HCV post-arrival and may therefore have increased risks of liver-related complications and hospitalization. We conducted a retrospective cohort study of reported HCV cases in Québec, Canada, from 1998 to 2007 that were linked to administrative health databases. Outcomes included all-cause and liver-related hospitalizations and in-hospital days in immigrants compared with nonimmigrants adjusted for age, sex, and comorbidities. We identified 20 139 HCV cases; 9% (N = 1821) were immigrants. At diagnosis, immigrants were older (47.6 vs 43.2 years) and more likely to have hepatocellular carcinoma (HCC; 0.93% vs 0.31%), while nonimmigrants were 2- to 10-fold more likely to have substance use-related comorbidities. Mean time to HCV diagnosis after arrival was 9.8 years. Nonimmigrants had higher rates of all-cause hospitalization (adjusted rate ratio [95% confidence interval], 1.42 [1.35-1.47]), driven by mental illness and injury and/or poisoning. Unadjusted liver-related hospitalization rates were similar between cohorts. After adjustment, immigrant status was associated with lower rates of liver-related hospitalization (0.68 [.53-.88]). Higher burden of all-cause hospitalization in nonimmigrants likely reflects more prevalent behavioral comorbidities. Similar liver-related hospitalization rates appear to be driven by older age in immigrants who were more likely to have HCC at diagnosis possibly reflecting delayed HCV diagnosis. These findings suggest that earlier screening and treatment in immigrants could play an important role in preventing HCV complications in this population. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
ERIC Educational Resources Information Center
Winther, Sven F.; And Others
The 1963 Freshman class at the University of New Mexico was studied through June, 1968, for performance patterns in relation to overall performance, high school grade-point average, male-female, Spanish surnames and non-Spanish surnames. In addition to university furnished data, questionnaires were submitted to a stratified random sample of…
Can BRICS Build Ivory Towers of Excellence? Giving New Meaning to World-Class Universities
ERIC Educational Resources Information Center
David, Solomon Arulraj; Motala, Shireen
2017-01-01
This paper aims to map the landscape of higher education transformation in the BRICS (Brazil, Russia, India, China and South Africa) nations while exploring the status of BRICS nations in some of the global university rankings and analysing their potential to give new meaning to notions such as excellent and world-class universities. The study…
UAVSAR Radar Imagery of Boreal Forests Around Quebec City, Canada
2009-09-01
JPL Uninhabited Aerial Vehicle Synthetic Aperture Radar collected this composite radar image around Québec City, Canada, during an 11-day campaign to study the structure of temperate and boreal forests.
NASA Technical Reports Server (NTRS)
Trevino, Robert C.
2009-01-01
The Texas Space Grant Consortium (TSGC) and the Exploration Systems Mission Directorate (ESMD) both have programs that present design challenges for university senior design classes that offer great opportunities for educational outreach and workforce development. These design challenges have been identified by NASA engineers and researchers as real design problems faced by the Constellation Program in its exploration missions and architecture. Student teams formed in their senior design class select and then work on a design challenge for one or two semesters. The senior design class follows the requirements set by their university, but it must also comply with the Accreditation Board for Engineering and Technology (ABET) in order to meet the class academic requirements. Based on a one year fellowship at a TSGC university under the NASA Administrator's Fellowship Program (NAFP) and several years of experience, results and metrics are presented on the NASA Design Challenge Program.
NASA Astrophysics Data System (ADS)
Isalie, J.; Codben, Druid; Seidwinder, Gruald; Heiller, Ereich; Young, Muddlekent; Stuntley, Hugene; Siegel, L. E. E.; Deliesie, Charlatan
2014-03-01
Ageism discrimination sociological-dysfunctionality crowdlynching shames physics pretentions of intellectual honesty and ethics! Extension to other departments:philo.,psych.,geo.,maths shames claims of honest education:BU,HU,NEU,UW,SDSU,ICTP/SISSA. Defrauding overdebted students, would be ``sciences'' become alas mere séances! Witness:70 year old Edward Siegel,PhD(70) firsts:multiband Hubbard-model decades pre-``Emery'' with Rosen/Feynman[IBM Conf.Comp./Math.(86)] trendy/ hyped ``Q-computing'' in ANN AI, google search-engine Page-Brin adaption; pre-trendy nanophysics [PSS(a) 11, 45(72);Scripta Met.13,913(79)];decade-earlier GMR discoverer[JMMM 7,312(78)] pre ``Fert''-``Gruenberg'' decade-earlier acoustic-emission F =ma rediscovery in Bak/BNL-hyped SOC; FUZZYICS Aristotle SoO rediscovery eliminating jargonial-obfuscation plaguing physics via implementation of Cohen-Stewart[Collapse of Chaos:Discovering Simplicity in ``Complex'' World] called for compl-icity/ simple-xity both simultaneously automaticallybig-`data'disambiguation via HoT;AMS Joint Mtg.(02) proofs:FLT;P ≠NPBSD conj.,Riemann-hypothesis as BEC; Benford's-law inversion discovering digits = bosons; (87) Majorana-fermion & HDM discoverer in complex-quantum-statistics in fractal-dimensions; ``it's a jack-in-the-box'' universe cosmology.
Shock wave loading of a magnetic guide
NASA Astrophysics Data System (ADS)
Kindt, L.
2011-10-01
The atom laser has long been a holy grail within atom physics and with the creation of an atom laser we hope to bring a similar revolution in to the field of atom optics. With the creation of the Bose-Einstein Condensate (BEC) in 1995 the path to an atom laser was initiated. An atom laser is continues source of BEC. In a Bose condensate all the atoms occupy the same quantum state and can be described by the same wave function and phase. With an atom laser the De Broglie wavelength of atoms can be much smaller than the wavelength of light. Due to the ultimate control over the atoms the atom laser is very interesting for atom optics, lithography, metrology, etching and deposition of atoms on a surface. All previous atom lasers have been created from atoms coupled out from an existing Bose-Einstein Condensate. There are different approaches but common to them all is that the duration of the output of the atom laser is limited by the size of the initial BEC and they all have a low flux. This leaves the quest to build a continuous high flux atom laser. An alternative approach to a continuous BEC beam is to channel a continuous ultra cold atomic beam into a magnetic guide and then cool this beam down to degeneracy. Cooling down a continuous beam of atoms faces three large problems: The collision rate has to be large enough for effective rethermalization, since evaporative cooling in 2D is not as effective as in 3D and a large thermal conductivity due to atoms with a high angular momentum causes heating downstream in the guide. We have built a 4 meter magnetic guide that is placed on a downward slope with a magnetic barrier in the end. In the guide we load packets of ultra cold rubidium atoms with a frequency rate large enough for the packets to merge together to form a continuous atomic beam. The atomic beam is supersonic and when the beam reaches the end barrier it will return and collide with itself. The collisions lowers the velocity of the beam into subsonic velocities and a shock wave is created between the two velocity regions. In order to conserve number of particle, momentum and enthalpy the density of the atomic beam passing through the shock wave must increase. We have build such a shock wave in an atomic beam and observed the density increase due to this. As an extra feature having a subsonic beam on a downward slope adds an extra density increase due to gravitational compression. Loading ultra cold atoms into a 3D trap from the dense subsonic beam overcomes the problem with 2D cooling and thermal conductivity. This was done and evaporative cooling was applied creating an unprecedented large number rubidium BEC.
NASA Astrophysics Data System (ADS)
Ludwig, Ralf
2010-05-01
Adapting to the impacts of climate change is certainly one of the major challenges in water resources management over the next decades. Adaptation to climate change risks is most crucial in this domain, since projected increase in mean air temperature in combination with an expected increase in the temporal variability of precipitation patterns will contribute to pressure on current water availability, allocation and management practices. The latter often involve the utilization of valuable infrastructure, such as dams, reservoirs and water intakes, for which adaptation options must by developed over long-term and often dynamic planning horizons. Research to establish novel methodologies for improved adaptation to climate change is thus very important and only beginning to emerge in regional watershed management. The presented project Q-BIC³, funded by the Bavarian Minstry for the Environment and the Québec Ministère du Développement économique, de l'Innovation et de l'Exportation, aims to develop and apply a newly designed spectrum of tools to support the improved assessment of adaptation options to climate change in regional watershed management. It addresses in particular selected study sites in Québec and Bavaria. The following key issues have been prioritized within Q-BIC³: i) The definition of potential adaptation options in the context of climate change for pre-targeted water management key issues using a subsequent and logical chain of modelling tools (climate, hydrological and water management modeling tools) ii) The definition of an approach that accounts for hydrological projection uncertainties in the search for potential adaptation options in the context of climate change iii) The investigation of the required complexity in hydrological models to estimate climate change impacts and to develop specific adaptation options for Québec and Bavaria watersheds. iv) The development and prototyping of a regionally transferable and modular modelling system for integrated watershed management under climate change conditions. The study sites under investigation, namely the Haut-Saint Francois and Gatineau watersheds in Québec and the Isar and Regnitz catchments in Bavaria, are under heavy anthropogenic use. Intense dam and reservoir operations and even water transfer systems are in place to satisfy multi-purpose demands on available water resources. These are imposing extreme modifications to the natural flow regimes. In the first phase of the project, climatic forcing, stemming from an ensemble of selected GCM and RCM runs, is applied to a variety of hydrological models with different complexity. The derived projections of future hydrological conditions serve to investigate, whether current operation rules and/or existing infrastructure needs to be adapted to a changing environment. First findings demonstrate the large uncertainties associated to the model chain outputs, but also indicate that related adaptation is indispensable to meet the challenges of the rapidly changing man-environment systems.
ERIC Educational Resources Information Center
Chang, Dian-fu; Wu, Cheng-ta; Ching, Gregory S.; Tang, Chia-wei
2009-01-01
The recent rise in globalization has brought forth a global wave of academic competitiveness, which has taken its strongest hold in East Asia. In order to attain world class status, Taiwan's Ministry of Education (MoE) initiated a project called Plan to Develop First-class Universities and Top-level Research Centers. The project is often coined…
Rubin, Mark; Kelly, Benjamin M
2015-10-05
This study tested a novel explanation for the positive relation between social class and mental health among university students. Students with a higher social class were expected to have experienced more authoritative and less authoritarian parenting styles; these parenting styles were expected to lead to greater friendship and social integration at university; and greater friendship and integration were expected to lead to better mental health. To test this model, the researchers asked 397 Australian undergraduate students to complete an online survey. The research used a cross-sectional correlational design, and the data was analysed using bootstrapped multiple serial mediation tests. Consistent with predictions, parenting style, general friendship and support, and social integration at university mediated the relation between social class and mental health. The present results suggest that working-class parenting styles may inhibit the development of socially-supportive friendships that protect against mental health problems. The potential effectiveness of interventions based on (a) social integration and (b) parenting style is discussed. Future research in this area should employ a longitudinal research design in order to arrive at clearer causal conclusions about the relations between social class, parenting styles, friendship, social integration, and mental health.
[Exploring some clinical aspects of the issue of Québec paternity.].
Martinat, S
1985-01-01
This article is part of a P.R.D. Research in Clinical Psychology on the father and, on a broader base, on Fatherhood ir} Quebec. The research was initiated in 1979 by the Department of Psychology of Quebec University jointly with the creation of a research laboratory around the theme "the role of the father in the Quebec society in evolution". The question of the father's place and functions in the society of Quebec is raised. The emphasis of the maternal presence in the relationship between parents and children is examined as well as the function of certain cultural traditions, religious ones in particular, in the resolution of certain problems of fatherhood. According to the author, the socio-cultural past of Quebec has a distinct influence on the problem of fatherhood. In a Quebec family the father is traditionally absent and a figure of authority. What is the situation today? Some clinical examples taken from the research are used to illustrate better certain aspects of the paternal dynamics.
ERIC Educational Resources Information Center
Hou, Angela Yung Chi; Morse, Robert; Chiang, Chung-Lin
2012-01-01
Since the start of the twenty-first century, university rankings have become internationalized. Global rankings have a variety of uses, levels of popularity and rationales and they are here to stay. An examination of the results of the current global ranking reveals that well-reputed world-class universities are amongst the top ranked ones. A…
Stephens, Nicole M; Fryberg, Stephanie A; Markus, Hazel Rose; Johnson, Camille S; Covarrubias, Rebecca
2012-06-01
American universities increasingly admit first-generation college students whose parents do not have 4-year degrees. Once admitted, these students tend to struggle academically, compared with continuing-generation students--students who have at least 1 parent with a 4-year degree. We propose a cultural mismatch theory that identifies 1 important source of this social class achievement gap. Four studies test the hypothesis that first-generation students underperform because interdependent norms from their mostly working-class backgrounds constitute a mismatch with middle-class independent norms prevalent in universities. First, assessing university cultural norms, surveys of university administrators revealed that American universities focus primarily on norms of independence. Second, identifying the hypothesized cultural mismatch, a longitudinal survey revealed that universities' focus on independence does not match first-generation students' relatively interdependent motives for attending college and that this cultural mismatch is associated with lower grades. Finally, 2 experiments at both private and public universities created a match or mismatch for first-generation students and examined the performance consequences. Together these studies revealed that representing the university culture in terms of independence (i.e., paving one's own paths) rendered academic tasks difficult and, thereby, undermined first-generation students' performance. Conversely, representing the university culture in terms of interdependence (i.e., being part of a community) reduced this sense of difficulty and eliminated the performance gap without adverse consequences for continuing-generation students. These studies address the urgent need to recognize cultural obstacles that contribute to the social class achievement gap and to develop interventions to address them. 2012 APA, all rights reserved
Crystallized and amorphous vortices in rotating atomic-molecular Bose-Einstein condensates
Liu, Chao-Fei; Fan, Heng; Gou, Shih-Chuan; Liu, Wu-Ming
2014-01-01
Vortex is a topological defect with a quantized winding number of the phase in superfluids and superconductors. Here, we investigate the crystallized (triangular, square, honeycomb) and amorphous vortices in rotating atomic-molecular Bose-Einstein condensates (BECs) by using the damped projected Gross-Pitaevskii equation. The amorphous vortices are the result of the considerable deviation induced by the interaction of atomic-molecular vortices. By changing the atom-molecule interaction from attractive to repulsive, the configuration of vortices can change from an overlapped atomic-molecular vortices to carbon-dioxide-type ones, then to atomic vortices with interstitial molecular vortices, and finally into independent separated ones. The Raman detuning can tune the ratio of the atomic vortex to the molecular vortex. We provide a phase diagram of vortices in rotating atomic-molecular BECs as a function of Raman detuning and the strength of atom-molecule interaction. PMID:24573303
Time series analysis of atmospheric mercury in Kuujjuarapik/Whapmagoostui (Québec)
NASA Astrophysics Data System (ADS)
Poissant, L.; Pilote, M.
2003-05-01
Recent mercury depletion events observed in the Arctic have opened the horizon to numerous new aspects on mercury fate and cycling in the environment. Total Gaseous Mercury and other Atmospheric Mercury speciations are measured in Kuujjuarapik/Whapmagoostui (Lat.: 55.30°N; Long.: 77.73°O) along the Hudson Bay (Québec) with Tekran 2537A, 1130 and 1135 units. The former is measured since August 1999 whereas the latter are measured during springtime periods over the last three years. Mercury Depletion Events are observed at this low latitude région. MDEs are observed between February and April and are occurring during both the day and nighttime periods. Typically, MDE in Kuujjuarapik are related to air temperature. During MDEs, a significant speciation conversion from Hg, to RGM and TPM is operating. However, ratios of TPM to RGM conversion are variable in time.
Jiang, Jian-Hua; John, Sajeev
2014-01-01
Semiconductor-microcavity polaritons are composite quasiparticles of excitons and photons, emerging in the strong coupling regime. As quantum superpositions of matter and light, polaritons have much stronger interparticle interactions compared with photons, enabling rapid equilibration and Bose-Einstein condensation (BEC). Current realizations based on 1D photonic structures, such as Fabry-Pérot microcavities, have limited light-trapping ability resulting in picosecond polariton lifetime. We demonstrate, theoretically, above-room-temperature (up to 590 K) BEC of long-lived polaritons in MoSe2 monolayers sandwiched by simple TiO2 based 3D photonic band gap (PBG) materials. The 3D PBG induces very strong coupling of 40 meV (Rabi splitting of 62 meV) for as few as three dichalcogenide monolayers. Strong light-trapping in the 3D PBG enables the long-lived polariton superfluid to be robust against fabrication-induced disorder and exciton line-broadening. PMID:25503586
DOE Office of Scientific and Technical Information (OSTI.GOV)
Tsuchiya, Shunji; Ohashi, Yoji; CREST
2010-09-15
We investigate the photoemission-type spectrum in a cold Fermi gas which was recently measured by the JILA group [Stewart et al., Nature (London) 454, 744 (2008)]. This quantity gives us very useful information about single-particle properties in the BCS-BEC crossover. In this paper, including pairing fluctuations within a T-matrix theory, as well as effects of a harmonic trap within the local density approximation, we show that spatially inhomogeneous pairing fluctuations due to the trap potential are an important key to understanding the observed spectrum. In the crossover region, while strong pairing fluctuations lead to the so-called pseudogap phenomenon in themore » trap center, such strong-coupling effects are found to be weak around the edge of the gas. Our results including this effect are shown to agree well with the recent photoemission data of the JILA group.« less
Integrated coherent matter wave circuits
Ryu, C.; Boshier, M. G.
2015-09-21
An integrated coherent matter wave circuit is a single device, analogous to an integrated optical circuit, in which coherent de Broglie waves are created and then launched into waveguides where they can be switched, divided, recombined, and detected as they propagate. Applications of such circuits include guided atom interferometers, atomtronic circuits, and precisely controlled delivery of atoms. We report experiments demonstrating integrated circuits for guided coherent matter waves. The circuit elements are created with the painted potential technique, a form of time-averaged optical dipole potential in which a rapidly moving, tightly focused laser beam exerts forces on atoms through theirmore » electric polarizability. Moreover, the source of coherent matter waves is a Bose–Einstein condensate (BEC). Finally, we launch BECs into painted waveguides that guide them around bends and form switches, phase coherent beamsplitters, and closed circuits. These are the basic elements that are needed to engineer arbitrarily complex matter wave circuitry.« less
Solitons and rogue waves in spinor Bose-Einstein condensates
NASA Astrophysics Data System (ADS)
Li, Sitai; Prinari, Barbara; Biondini, Gino
2018-02-01
We present a general classification of one-soliton solutions as well as families of rogue-wave solutions for F =1 spinor Bose-Einstein condensates (BECs). These solutions are obtained from the inverse scattering transform for a focusing matrix nonlinear Schrödinger equation which models condensates in the case of attractive mean-field interactions and ferromagnetic spin-exchange interactions. In particular, we show that when no background is present, all one-soliton solutions are reducible via unitary transformations to a combination of oppositely polarized solitonic solutions of single-component BECs. On the other hand, we show that when a nonzero background is present, not all matrix one-soliton solutions are reducible to a simple combination of scalar solutions. Finally, by taking suitable limits of all the solutions on a nonzero background we also obtain three families of rogue-wave (i.e., rational) solutions.
Solitons and rogue waves in spinor Bose-Einstein condensates.
Li, Sitai; Prinari, Barbara; Biondini, Gino
2018-02-01
We present a general classification of one-soliton solutions as well as families of rogue-wave solutions for F=1 spinor Bose-Einstein condensates (BECs). These solutions are obtained from the inverse scattering transform for a focusing matrix nonlinear Schrödinger equation which models condensates in the case of attractive mean-field interactions and ferromagnetic spin-exchange interactions. In particular, we show that when no background is present, all one-soliton solutions are reducible via unitary transformations to a combination of oppositely polarized solitonic solutions of single-component BECs. On the other hand, we show that when a nonzero background is present, not all matrix one-soliton solutions are reducible to a simple combination of scalar solutions. Finally, by taking suitable limits of all the solutions on a nonzero background we also obtain three families of rogue-wave (i.e., rational) solutions.
Satellite tracking and earth dynamics research programs
NASA Technical Reports Server (NTRS)
1982-01-01
The SAO laser site in Arequipa continued routine operations throughout the reporting period except for the months of March and April when upgrading was underway. The laser in Orroral Valley was operational through March. Together with the cooperating stations in Wettzell, Grasse, Kootwikj, San Fernando, Helwan, and Metsahove the laser stations obtained a total of 37,099 quick-look observations on 978 passes of BE-C, Starlette, and LAGEOS. The Network continued to track LAGEOS at highest priority for polar motion and Earth rotation studies, and for other geophysical investigations, including crustal dynamics, Earth and ocean tides, and the general development of precision orbit determination. The Network performed regular tracking of BE-C and Starlette for refined determinations of station coordinate and the Earth's gravity field and for studies of solid earth dynamics. Monthly statistics of the passes and points are given by station and by satellite.
Room temperature current injection polariton light emitting diode with a hybrid microcavity.
Lu, Tien-Chang; Chen, Jun-Rong; Lin, Shiang-Chi; Huang, Si-Wei; Wang, Shing-Chung; Yamamoto, Yoshihisa
2011-07-13
The strong light-matter interaction within a semiconductor high-Q microcavity has been used to produce half-matter/half-light quasiparticles, exciton-polaritons. The exciton-polaritons have very small effective mass and controllable energy-momentum dispersion relation. These unique properties of polaritons provide the possibility to investigate the fundamental physics including solid-state cavity quantum electrodynamics, and dynamical Bose-Einstein condensates (BECs). Thus far the polariton BEC has been demonstrated using optical excitation. However, from a practical viewpoint, the current injection polariton devices operating at room temperature would be most desirable. Here we report the first realization of a current injection microcavity GaN exciton-polariton light emitting diode (LED) operating under room temperature. The exciton-polariton emission from the LED at photon energy 3.02 eV under strong coupling condition is confirmed through temperature-dependent and angle-resolved electroluminescence spectra.
NASA Astrophysics Data System (ADS)
Hirata, Satoshi; Kurita, Nobuyuki; Yamada, Motoki; Tanaka, Hidekazu
2017-05-01
K2CuF4 is magnetically described as a spin-1/2 , quasi-two-dimensional (2D), square-lattice XXZ ferromagnet with weak easy-plane anisotropy. The magnetic ordering for an applied magnetic field H parallel to the c axis is equivalent to the Bose-Einstein condensation (BEC) of lattice bosons, as discussed by Matsubara and Matsuda [T. Matsubara and H. Matsuda, Prog. Theor. Phys. 16, 569 (1956), 10.1143/PTP.16.569]. Magnetization and specific-heat measurements were performed to obtain the temperature versus magnetic field phase diagram for H ∥c . The phase boundary between polarized and ordered phases was found to be expressed by the power law Hc(T ) -Hc(0 ) ∝Tϕ with exponent ϕ ≈1.0 in a wide temperature range, in agreement with the theory of quasi-2D BEC.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Uchino, Shun; Kobayashi, Michikazu; Ueda, Masahito
2010-06-15
We develop Bogoliubov theory of spin-1 and spin-2 Bose-Einstein condensates (BECs) in the presence of a quadratic Zeeman effect, and derive the Lee-Huang-Yang (LHY) corrections to the ground-state energy, pressure, sound velocity, and quantum depletion. We investigate all the phases of spin-1 and spin-2 BECs that can be realized experimentally. We also examine the stability of each phase against quantum fluctuations and the quadratic Zeeman effect. Furthermore, we discuss a relationship between the number of symmetry generators that are spontaneously broken and that of Nambu-Goldstone (NG) modes. It is found that in the spin-2 nematic phase there are special Bogoliubovmore » modes that have gapless linear dispersion relations but do not belong to the NG modes.« less
BEC-BCS crossover and the liquid-gas phase transition in hot and dense nuclear matter
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jin Meng; Urban, Michael; Schuck, Peter
2010-08-15
The effect of nucleon-nucleon correlations in symmetric nuclear matter at finite temperature is studied beyond BCS theory. Starting from a Hartree-Fock description of nuclear matter with the Gogny effective interaction, we add correlations corresponding to the formation of preformed pairs and scattering states above the superfluid critical temperature within the in-medium T-matrix approach, which is analogous to the Nozieres-Schmitt-Rink theory. We calculate the critical temperature for a BEC superfluid of deuterons, of a BCS superfluid of nucleons, and in the crossover between these limits. The effect of the correlations on thermodynamic properties (equation of state, energy, entropy) and the liquid-gasmore » phase transition is discussed. Our results show that nucleon-nucleon correlations beyond BCS play an important role for the properties of nuclear matter, especially in the low-density region.« less
Modified many-body wave function for BCS-BEC crossover in Fermi gases
DOE Office of Scientific and Technical Information (OSTI.GOV)
Tan, Shina; Levin, K.
2006-10-15
We present a many-body formalism for BCS-BEC crossover, which represents a modification of the Bardeen-Cooper-Schrieffer-Leggett ground state to include four-fermion and higher correlations. In the Bose-Einstein condensate regime, we show how our approach contains the four-fermion behavior of Petrov et al. and associated scattering length a{sub dd} at short distances and, second, reduces to composite-boson Bogoliubov physics at long distances. It reproduces the Lee-Yang term, whose numerical value is also fixed by a{sub dd}. We have also examined the next term beyond the Lee-Yang correction in a phenomenological fashion, building on cloud size data and collective mode experiments, although onemore » has to view this phenomenological analysis with some caution since experiments are in a state of flux and are performed close to unitarity.« less
Pairing induced superconductivity in holography
NASA Astrophysics Data System (ADS)
Bagrov, Andrey; Meszena, Balazs; Schalm, Koenraad
2014-09-01
We study pairing induced superconductivity in large N strongly coupled systems at finite density using holography. In the weakly coupled dual gravitational theory the mechanism is conventional BCS theory. An IR hard wall cut-off is included to ensure that we can controllably address the dynamics of a single confined Fermi surface. We address in detail the interplay between the scalar order parameter field and fermion pairing. Adding an explicitly dynamical scalar operator with the same quantum numbers as the fermion-pair, the theory experiences a BCS/BEC crossover controlled by the relative scaling dimensions. We find the novel result that this BCS/BEC crossover exposes resonances in the canonical expectation value of the scalar operator. This occurs not only when the scaling dimension is degenerate with the Cooper pair, but also with that of higher derivative paired operators. We speculate that a proper definition of the order parameter which takes mixing with these operators into account stays finite nevertheless.
Structural investigation of re-deposited layers in JET
NASA Astrophysics Data System (ADS)
Likonen, J.; Vainonen-Ahlgren, E.; Khriachtchev, L.; Coad, J. P.; Rubel, M.; Renvall, T.; Arstila, K.; Hole, D. E.; Contributors to the EFDA-JET Work-programme
2008-07-01
JET Mk-II Gas Box divertor tiles exposed in 1998-2001 have been analysed with various ion beam techniques, secondary ion mass spectrometry (SIMS) and Raman spectroscopy. Inner divertor wall tiles removed in 2001 were covered with a duplex film. The inner layer was very rich in metallic impurities, with Be/C ˜ 1 and H-isotopes only present at low concentrations. The outer layer contained higher concentrations of D than normal for plasma-facing surfaces in JET (D/C ˜ 0.4), and Be/C ˜ 0.14. Raman and SIMS analyses show that the deposited films on inner divertor tiles are hydrogenated amorphous carbon with low sp 3 fractions. The deposits have polymeric structure and low density. Both Raman scattering and SIMS indicate that films on inner divertor wall Tiles 1 and 3, and on floor Tile 4 have some differences in the chemical structure of the deposited films
Bloch-Siegert shift in an interacting Bose-Einstein condensate
NASA Astrophysics Data System (ADS)
Zhang, Jinyi; Eigen, Christoph; Lopes, Raphael; Garratt, Sam; Rousso, David; Smith, Robert P.; Hadzibabic, Zoran; Navon, Nir
2017-04-01
The Bloch-Siegert shift (BSS) is a paradigmatic frequency shift that arises from the nonlinear response of a two-level system (TLS) subjected to strong driving fields. When a TLS is driven by a linearly polarized field, the co-rotating-wave component leads to the famous Rabi oscillations. By contrast the co-rotating-wave component, whose role is usually neglected in a weak driving, leads to a frequency shift of the TLS resonance frequency. This phenomenon is encountered in various areas, from quantum optics to nuclear magnetic resonance.Here, we investigate the BSS in a box-trapped 87 Rb Bose-Einstein condensate (BEC) driven by a strong oscillating magnetic field gradient. By tuning the chemical potential of the gas, we investigate how the BSS evolves from the ideal shift of the two lowest energy levels of a single particle in a box to the unexplored shift of long-wavelength collective excitations of the interacting BEC.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ryu, C.; Boshier, M. G.
An integrated coherent matter wave circuit is a single device, analogous to an integrated optical circuit, in which coherent de Broglie waves are created and then launched into waveguides where they can be switched, divided, recombined, and detected as they propagate. Applications of such circuits include guided atom interferometers, atomtronic circuits, and precisely controlled delivery of atoms. We report experiments demonstrating integrated circuits for guided coherent matter waves. The circuit elements are created with the painted potential technique, a form of time-averaged optical dipole potential in which a rapidly moving, tightly focused laser beam exerts forces on atoms through theirmore » electric polarizability. Moreover, the source of coherent matter waves is a Bose–Einstein condensate (BEC). Finally, we launch BECs into painted waveguides that guide them around bends and form switches, phase coherent beamsplitters, and closed circuits. These are the basic elements that are needed to engineer arbitrarily complex matter wave circuitry.« less
Nakayama, Rumiko; Nakanishi, Yoshifumi; Nagahama, Fumiyo; Nakajima, Makoto
2015-06-01
The present study examined the influence of interpersonal motivation on university adjustment in freshman students enrolled in a First Year Experience (FYE) class. An interpersonal motivation scale and a university adjustment (interpersonal adjustment and academic adjustment) scale were administered twice to 116 FYE students; data from the 88 students who completed both surveys were analyzed. Results from structural equation modeling indicated a causal relationship between interpersonal, motivation and university adjustment: interpersonal adjustment served as a mediator between academic adjustment and interpersonal motivation, the latter of which was assessed using the internalized motivation subscale of the Interpersonal Motivation Scale as well as the Relative Autonomy Index, which measures the autonomy in students' interpersonal attitudes. Thus, revising the FYE class curriculum to include approaches to lowering students' feelings of obligation and/or anxiety in their interpersonal interactions might improve their adjustment to university.
Integrating Creativity into Online University Classes
ERIC Educational Resources Information Center
Muirhead, Brent
2007-01-01
In this article, the author provides a concise discussion on creativity, defining the term, sharing theoretical background information and offering insights into promoting creativity in online university classes. Emphasis will be placed on relevant ways to integrate creativity into instructional activities across the academic disciplines. He…
Built Environment Predictors of Active Travel to School Among Rural Adolescents
Dalton, Madeline A.; Longacre, Meghan R.; Drake, Keith M.; Gibson, Lucinda; Adachi-Mejia, Anna M.; Swain, Karin; Xie, Haiyi; Owens, Peter M.
2011-01-01
Background Most studies of active travel to school (ATS) have been conducted in urban or suburban areas and focused on young children. Little is known about ATS among rural adolescents. Purpose Describe adolescent ATS in two predominantly rural states and determine if school neighborhood built environment characteristics (BECs) predict ATS after adjusting for school and individual characteristics. Methods Sixteen BECs were assessed through census data and onsite observations of 45 school neighborhoods in 2007. ATS and individual characteristics were assessed through telephone surveys with 1552 adolescents and their parents between 2007 and 2008. Active travelers were defined as those who walked/cycled to/from school >= 1 day/week. Hierarchic linear modeling was used for analysis, conducted in 2009. Results Slightly less than half (n=735) of the sample lived within 3 miles of school, of whom 388 (52.8%) were active travelers. ATS frequency varied by season, ranging from a mean of 1.7 (SD=2.0) days/week in the winter to 3.7 (SD=1.6) in the spring. Adolescents who attended schools in highly dense residential neighborhoods with sidewalks were most likely to be active travelers. ATS frequency was greater in school neighborhoods with high residential and intersection densities, on-street parking, food outlets, and taller and continuous buildings with small setbacks. Conclusions BECs that support safe travel may be necessary to allow for ATS, whereas ATS frequency among adolescents may be influenced by a wider variety of design characteristics. Additional strategies to promote ATS and physical activity are needed in rural areas due to long commuting distances for many students. PMID:21335262
NASA Technical Reports Server (NTRS)
Berkowitz, Dan E.; White, Ron; Li, Dechun; Minhas, Khalid M.; Cernetich, Amy; Kim, Soonyul; Burke, Sean; Shoukas, Artin A.; Nyhan, Daniel; Champion, Hunter C.;
2003-01-01
BACKGROUND: Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system, the biochemical mechanisms remain controversial. L-arginine, the NO synthase (NOS) precursor, is also a substrate for arginase. We tested the hypotheses that arginase reciprocally regulates NOS by modulating L-arginine bioavailability and that arginase is upregulated in aging vasculature, contributing to depressed endothelial function. METHODS AND RESULTS: Inhibition of arginase with (S)-(2-boronoethyl)-L-cysteine, HCl (BEC) produced vasodilation in aortic rings from young (Y) adult rats (maximum effect, 46.4+/-9.4% at 10(-5) mol/L, P<0.01). Similar vasorelaxation was elicited with the additional arginase inhibitors N-hydroxy-nor-L-arginine (nor-NOHA) and difluoromethylornithine (DFMO). This effect required intact endothelium and was prevented by 1H-oxadiazole quinoxalin-1-one (P<0.05 and P<0.001, respectively), a soluble guanylyl cyclase inhibitor. DFMO-elicited vasodilation was greater in old (O) compared with Y rat aortic rings (60+/-6% versus 39+/-6%, P<0.05). In addition, BEC restored depressed L-arginine (10(-4) mol/L)-dependent vasorelaxant responses in O rings to those of Y. Arginase activity and expression were increased in O rings, whereas NOS activity and cyclic GMP levels were decreased. BEC and DFMO suppressed arginase activity and restored NOS activity and cyclic GMP levels in O vessels to those of Y. CONCLUSIONS: These findings demonstrate that arginase modulates NOS activity, likely by regulating intracellular L-arginine availability. Arginase upregulation contributes to endothelial dysfunction of aging and may therefore be a therapeutic target.
Shen, Xiao-Fei; Teng, Yan; Sha, Kai-Hui; Wang, Xin-Yuan; Yang, Xiao-Long; Guo, Xiao-Juan; Ren, Lai-Bin; Wang, Xiao-Ying; Li, Jingyu; Huang, Ning
2016-11-12
Uropathogenic Escherichia coli (UPEC), the primary uropathogen, adhere to and invade bladder epithelial cells (BECs) to establish a successful urinary tract infection (UTI). Emerging antibiotic resistance requires novel nonantibiotic strategies. Our previous study indicated that luteolin attenuated adhesive and invasive abilities as well as cytotoxicity of UPEC on T24 BECs through down-regulating UPEC virulence factors. The aims of this study were to investigate the possible function of the flavonoid luteolin and the mechanisms by which luteolin functions in UPEC-induced bladder infection. Firstly, obvious reduction of UPEC invasion but not adhesion were observed in luteolin-pretreated 5637 and T24 BECs sa well as mice bladder via colony counting. The luteolin-mediated suppression of UPEC invasion was linked to elevated levels of intracellular cAMP induced by inhibiting the activity of cAMP-phosphodiesterases (cAMP-PDEs), which resulting activation of protein kinase A, thereby negatively regulating Rac1-GTPase-mediated actin polymerization. Furthermore, p38 MAPK was primarily and ERK1/2 was partially involved in luteolin-mediated suppression of UPEC invasion and actin polymerization, as confirmed with chemical activators of p38 MAPK and ERK1/2. These data suggest that luteolin can protect bladder epithelial cells against UPEC invasion. Therefore, luteolin or luteolin-rich products as dietary supplement may be beneficial to control the UPEC-related bladder infections, and cAMP-PDEs may be a therapy target for UTIs treatment. © 2016 BioFactors, 42(6):674-685, 2016. © 2016 International Union of Biochemistry and Molecular Biology.
Levels and trends in cigarette contraband in Canada
Guindon, G Emmanuel; Burkhalter, Robin; Brown, K Stephen
2017-01-01
Background There is overwhelming evidence that increases in tobacco taxes reduce tobacco use, save lives and increase government tax revenue. High taxes, however, create an incentive to devise ways to avoid or evade tobacco taxes through contraband tobacco. The associated consequences are significant and call for an accurate measurement of contraband's magnitude. However, its illegal nature makes the levels and trends in contraband intrinsically difficult to measure accurately. Objective To examine levels and trends in cigarette contraband in Canada. Methods We employed 2 approaches: first, we contrasted estimates of tax-paid cigarettes sales with consumption estimates based on survey data; second, we used data from several individual-level surveys that examined smokers' purchasing and use behaviours. We placed a particular emphasis on the provinces of Québec and Ontario because existing research suggests that cigarette contraband levels are far higher than in any other province. Results The estimates presented show a clear upward trend from the early 2000s in cigarette contraband in Québec and Ontario followed by, on the whole, a decreasing trend from about 2007 to 2009. None of the data presented provide support to the narrative that cigarette contraband has been increasing in recent years. Of note are Québec estimates which suggest relatively low levels of cigarette contraband since 2010, at levels no higher than in the early 2000s. Conclusions The data presented suggest that policies to tackle cigarette contraband introduced from the mid-2000s to late 2000s, at both federal and provincial levels, may have dampened the demand for contraband cigarettes. PMID:27601454
The Advantages of Hybrid 4DEnVar in the Context of the Forecast Sensitivity to Initial Conditions
NASA Astrophysics Data System (ADS)
Song, Hyo-Jong; Shin, Seoleun; Ha, Ji-Hyun; Lim, Sujeong
2017-11-01
Hybrid four-dimensional ensemble variational data assimilation (hybrid 4DEnVar) is a prospective successor to three-dimensional variational data assimilation (3DVar) in operational weather prediction centers currently developing a new weather prediction model and those that do not operate adjoint models. In experiments using real observations, hybrid 4DEnVar improved Northern Hemisphere (NH; 20°N-90°N) 500 hPa geopotential height forecasts up to 5 days in a NH summer month compared to 3DVar, with statistical significance. This result is verified against ERA-Interim through a Monte Carlo test. By a regression analysis, the sensitivity of 5 day forecast is associated with the quality of the initial condition. The increased analysis skill for midtropospheric midlatitude temperature and subtropical moisture has the most apparent effect on forecast skill in the NH including a typhoon prediction case. Through attributing the analysis improvements by hybrid 4DEnVar separately to the ensemble background error covariance (BEC), its four-dimensional (4-D) extension, and climatological BEC, it is revealed that the ensemble BEC contributes to the subtropical moisture analysis, whereas the 4-D extension does to the midtropospheric midlatitude temperature. This result implies that hourly wind-mass correlation in 6 h analysis window is required to extract the potential of hybrid 4DEnVar for the midlatitude temperature analysis to the maximum. However, the temporal ensemble correlation, in hourly time scale, between moisture and another variable is invalid so that it could not work for improving the hybrid 4DEnVar analysis.
Simon, Liz; Siggins, Robert; Winsauer, Peter; Brashear, Meghan; Ferguson, Tekeda; Mercante, Don; Song, Kejing; Vande Stouwe, Curtis; Nelson, Steve; Bagby, Gregory; Amedee, Angela; Molina, Patricia E
2018-02-01
Alcohol use disorder (AUD) is a frequent comorbidity among people living with HIV/AIDS (PLWHA). Alcohol consumption is a significant predictor of nonadherence to antiretroviral therapy (ART), as well as worsening immunological and virological indicators among PLWHA. Clinical studies indicate that higher viral loads increase sensitivity to alcohol in PLWHA. The factors that influence alcohol kinetics after HIV infection and initiation of ART are not well understood, limiting the information upon which interventions can be designed to ameliorate the impact of alcohol misuse on this vulnerable patient population. To better understand the relationship between viral load and alcohol kinetics, we measured changes in doses of intragastric ethanol administration to achieve target blood ethanol concentration (BEC) in a rhesus macaque model of chronic binge alcohol (CBA) administration and acute changes following a single acute binge dose of alcohol (ABA) pre- and post-simian immunodeficiency virus (SIV) infection, and following ART initiation. Our results from CBA (14 months)-administered SIV-infected male macaques showed that, following ART initiation, macaques required higher doses of alcohol to achieve a target peak BEC compared with non-ART-treated SIV-infected macaques. In animals given ABA, we found prolonged duration of elevated BEC and decreased elimination rate of alcohol that was not corrected following 7 weeks of ART. These findings suggest that binge drinking associated with AUD could negatively interact with HIV infection and enhance disease progression. These findings further support the need for implementation of behavioral or therapeutic interventions to decrease alcohol consumption to improve the quality of life in PLWHA.
Seroconversion for cytomegalovirus infection in a cohort of pregnant women in Québec, 2010-2013.
Lamarre, V; Gilbert, N L; Rousseau, C; Gyorkos, T W; Fraser, W D
2016-06-01
Cytomegalovirus (CMV) is the leading cause of congenital infection and non-genetic sensorineural hearing loss in children. There are no recent data on the incidence of CMV infection during pregnancy in Canada. This present study was undertaken to determine the seroprevalence of CMV IgG antibodies and the rate of seroconversion in a cohort of pregnant women in the province of Québec, Canada. We used serum samples and questionnaire data collected as part of the 3D Pregnancy and Birth Cohort Study (2010-2013) conducted in Québec, Canada. CMV IgG antibodies were determined in serum samples collected at the first and third trimesters. Associations between independent variables and seroprevalence were assessed using logistic regression, and associations with seroconversions, by Poisson regression. Of 1938 pregnant women tested, 40·4% were seropositive for CMV at baseline. Previous CMV infection was associated with: working as a daycare educator, lower education, lower income, having had children, first language other than French or English, and being born outside Canada or the United States. Of the 1122 initially seronegative women, 24 (2·1%) seroconverted between their first and third trimesters. The seroconversion rate was 1·4 [95% confidence interval (CI) 0·9-2·1]/10 000 person-days at risk or 3·9 (95% CI 2·5-5·9)/100 pregnancies (assuming a 280-day gestation). The high proportion of pregnant women susceptible to CMV infection (nearly 60%) and the subsequent rate of seroconversion are of concern.
The impacts of mandatory service on students in service-learning classes.
Dienhart, Carolyn; Maruyama, Geoffrey; Snyder, Mark; Furco, Andrew; McKay, Monica Siems; Hirt, Laurel; Huesman, Ronald
2016-01-01
This naturalistic study examined differences in students' motivations for elective versus required service-learning (SL) classes. Students in two successive academic years' cohorts were surveyed by the SL center at a large Midwestern university. Analyses compared classes differing in requirements for community-based service. Students required to participate in community service as part of a class within a program required for admission to a university were less likely to: want to be involved in future community work; enroll in another SL class; and recommend their class, compared to other groups of students, including others from classes in which SL was required as part of the program in which students were enrolled. These findings suggest that students' motivations to participate in community-engaged activities are not shaped simply by whether or not community engagement is required in SL classes, but also by other factors including how the engagement opportunity is contextualized.
Improving driver decisions and performance in high-speed, multilane, complex conditions.
DOT National Transportation Integrated Search
2009-01-01
In an effort to reduce fatalities resulting from traffic collisions, Californias Strategic Highway Safety Plan identified : 16 Challenge Areas under the State Highway Safety Plan. Improper driving decisions about the right of way and : turning bec...
Saini, V; McClure, J T; Scholl, D T; DeVries, T J; Barkema, H W
2012-04-01
Surveillance of antimicrobial use and resistance is needed to manage antimicrobial resistance in bacteria. In this study, data were collected on antimicrobial use and resistance in Staphylococcus aureus (n=562), isolated from intramammary infections and (sub)clinical mastitis cases on 89 dairy farms in 4 regions of Canada [Alberta, Ontario, Québec, and the Maritime Provinces (Prince Edward Island, Nova Scotia, and New Brunswick)]. Dairy producers were asked to deposit empty drug containers into specially provided receptacles, and antimicrobial drug use rate was calculated to quantify antimicrobial use. Minimum inhibitory concentrations were determined using the Sensititer bovine mastitis plate system (TREK Diagnostic Systems Inc., Cleveland, OH), containing antimicrobials commonly used for mastitis treatment and control. Multivariable logistic regression models were built to determine herd-level risk factors of penicillin, ampicillin, pirlimycin, penicillin-novobiocin combination, tetracycline and sulfadimethoxine resistance in Staph. aureus isolates. Intramammary administration of the penicillin-novobiocin combination for dry cow therapy was associated with penicillin and ampicillin resistance [odds ratio (OR): 2.17 and 3.10, respectively]. Systemic administration of penicillin was associated with penicillin resistance (OR: 1.63). Intramammary administration of pirlimycin for lactating cow mastitis treatment was associated with pirlimycin resistance as well (OR: 2.07). Average herd parity was associated with ampicillin and tetracycline resistance (OR: 3.88 and 0.02, respectively). Average herd size was also associated with tetracycline resistance (OR: 1.02). Dairy herds in the Maritime region had higher odds of penicillin and lower odds of ampicillin resistance than dairy herds in Québec (OR: 2.18 and 0.19, respectively). Alberta dairy herds had lower odds of ampicillin and sulfadimethoxine resistance than dairy herds in Québec (OR: 0.04 and 0.08, respectively). Ontario dairy herds had lower odds of tetracycline and sulfadimethoxine resistance than dairy herds in Québec (OR: 0.05 and 0.33, respectively). Herd-level use of certain antimicrobials administered for mastitis treatment and control, such as intramammary penicillin and pirlimycin as well as systemically administered penicillin and florfenicol, was positively associated with antimicrobial resistance in bovine mastitis pathogens in the field conditions. Differences in antimicrobial resistance outcomes across 4 regions of Canada were observed. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
Blais, Lucie; Vilain, Anne; Kettani, Fatima-Zohra; Forget, Amélie; Lalonde, Geneviève; Beauchesne, Marie-France; Ducharme, Francine M; Lemière, Catherine
2014-01-01
Objectives and hypotheses Adherence to inhaled corticosteroids (ICS) is a major issue in asthma. This study aimed to estimate the accuracy of the days’ supply and number of refills allowed, variables recorded in Québec claims databases and used to estimate adherence, and to develop correction factors, if required. We hypothesised that the accuracy of the days’ supply for ICS would be low whereas the accuracy of the number of refills allowed would be high. Setting 40 community pharmacies in Québec (Canada) and a medication registry. Participants We collected data for 1108 ICS original prescriptions stored in the 40 pharmacies (sample 1), and we obtained a second sample of 2676 ICS prescriptions selected from reMed, a medication registry (sample 2). Primary and secondary outcomes We estimated the concordance of the days’ supply and number of refills between Québec claims databases and the original prescription from sample 1. We developed a correction factor for the days’ supply in sample 1 and validated it in sample 2. Analyses were stratified by age: 0–11 and 12–64 years. Results In sample 1, the concordance for the days’ supply was 39.6% (95% CI 37.6% to 41.6%) in those aged 0–11 years and 56% (54.9% to 57.2%) in those aged 12–64 years. The concordance increased to 59.4% (58.2% to 60.5%) in those aged 0–11 years and 74.2% (73.5% to 74.9%) in those aged 12–64 years after applying the correction factors in sample 2. The concordance for the refills allowed was 92.1% (91% to 93.1%) in those aged 0–11 years and 93.1% (92.5% to 93.7%) in those aged 12–64 years in sample 1. Conclusions The accuracy of the days’ supply was moderate among those aged 0–11 years and substantial among those aged 12–64 years after applying the correction factors. The accuracy of the number of refills was almost perfect in both groups. PMID:25432902
An interview with Peter H. Buschang.
Buschang, Peter H; dos Santos-Pinto, Ary; Araújo, Eustáquio; Ribeiro, Gerson Luiz Ulema; Jacob, Helder Baldi; Gandini Júnior, Luiz Gonzaga
2014-01-01
Dr. Peter Buschang is regent professor and director of orthodontic research. He has been at Texas A&M University Baylor College of Dentistry since 1988. Dr. Buschang received his PhD in 1980 from the University of Texas at Austin; he spent 3 years as a NIDR postdoctoral fellow at the University of Connecticut, and five years as a FRSQ scholar at the University of Montreal. Every year, Dr. Buschang teaches in 16 different courses, 7 of which he directs. In addition to more than 100 lecture hours per year, he spends hundreds of hours mentoring students. For his teaching efforts, Dr. Buschang was awarded the Robert E. Gaylord Award of Excellence in Orthodontic education in 1992, 1998, 2004, and 2010. He also gives 1-2 day evidence-based CE courses throughout the world. The residents he has taught recently honored him by pledging to fund the Peter H. Buschang Endowed Professorship of Orthodontics. His research interests pertain to craniofacial growth and assessment of treatment effects. Dr. Buschang has been funded regularly over the years by the Medical Research Council of Canada, Fonds de le Recherche en Santé du Québec, the NIH, and the American Association of Orthodontics Foundation. He has mentored over 140 Master's and PhD students, and 49 dental students. Dr. Buschang has published over 250 peer-reviewed articles, 15 book chapters and 198 abstracts. He has given over 150 invited talks and lectures in 14 different countries. For his work with the American Board of Orthodontics, Dr. Buschang was awarded the Earl E. and Wilma S. Shepard Award. Dr. Buschang is the only non-orthodontist ever to have been made an honorary member of both the American Association of Orthodontics (2005) and the Edward H. Angle Society of Orthodontics (2009), the two most prestigious orthodontic groups.
The Opinions about Relationship between Students and Teachers in the Class of Hands-on
NASA Astrophysics Data System (ADS)
Pigultong, M.
2018-02-01
This research has the purpose to study on 1) Relationship between Students and Teachers in the Class of Hands - on and 2) Class Management at Rajamangala University of Technology Thanyaburi. The research consists of collecting information from 400 students who have valid student status in 2016 at Rajamangala University of Technology Thanyaburi. This research uses content analysis technique, Average (-X) and Standard Deviation to interpret the information. The results of the research focus on 2 topics 1) The Human relationship between Students and Teachers. The samples group had high expectations of human relationship (x=3.87). 2) Class Management. The samples group had high expectations of Class Management (x=3.88).
Assessing a New Approach to Class-Based Affirmative Action
ERIC Educational Resources Information Center
Gaertner, Matthew N.
2011-01-01
In November, 2008, Colorado and Nebraska voted on amendments that sought to end race-based affirmative action at public universities. In anticipation of the vote, Colorado's flagship public institution--The University of Colorado at Boulder (CU)--explored statistical approaches to support class-based affirmative action. This paper details CU's…
Economies of Scale and Large Classes
ERIC Educational Resources Information Center
Saiz, Martin
2014-01-01
Making classes larger saves money--and public universities across the country have found it a useful strategy to balance their budgets after decades of state funding cuts and increases to infrastructure costs. Where this author teaches, in the College of Social and Behavioral Sciences at California State University, Northridge (CSUN),…
ERIC Educational Resources Information Center
Lane, Erin S.; Harris, Sara E.
2015-01-01
The authors developed a classroom observation protocol for quantitatively measuring student engagement in large university classes. The Behavioral Engagement Related to instruction (BERI) protocol can be used to provide timely feedback to instructors as to how they can improve student engagement in their classrooms.
Universal Design for Learning in Teaching Large Lecture Classes
ERIC Educational Resources Information Center
Dean, Tereza; Lee-Post, Anita; Hapke, Holly
2017-01-01
To augment traditional lecture with instructional tools that provide options for content representation, learner engagement, and learning expression, we followed the Universal Design for Learning (UDL) principles to design and implement a learning environment for teaching and learning in large lecture classes. To this end, we incorporated four…
Assessing a New Approach to Class-Based Affirmative Action
ERIC Educational Resources Information Center
Gaertner, Matthew Newman
2011-01-01
In November, 2008, Colorado and Nebraska voted on amendments that sought to end race-based affirmative action at public universities in those states. In anticipation of the vote, the University of Colorado at Boulder (CU) explored statistical approaches to support class-based (i.e., socioeconomic) affirmative action. This dissertation introduces…
Teaching Reading in Foreign Language Classes: A Bibliography.
ERIC Educational Resources Information Center
Greenewald, M. Jane
This bibliography of articles, books, and ERIC documents on the teaching of reading in foreign language classes is intended for university content reading specialists, reading coordinators and consultants, secondary and university foreign language teachers, and methodologists in foreign language education. More than 95 sources are listed in the…
Participant Analysis of a Multi-Class, Multi-State, On-Line, Discussion List.
ERIC Educational Resources Information Center
Knupfer, Nancy Nelson; And Others
As interest in distance education increases, many university instructors are experimenting with listserv discussion within their courses. Six educational technology professors at four universities initiated a listserv discussion group within their various classes for 52 graduate students. Discussion topics were four general themes within…
ERIC Educational Resources Information Center
Markert, Ronald J.
Medical specialty choice and reasons for change among those Wright State University students who switched their choice between entry and graduation were studied, based on questionnaire findings. For the class of 1982, 35 of the 70 students chose as their eventual specialty their preference at entry to medical school. Primary care specialties…
RATIONALE: Epidemiologic studies report associations between ambient air pollution particulate matter (PM) and various indices of cardiopulmonary morbidity and mortality. A leading hypothesis contends that smaller ultrafine (UF) particles induce a greater physiologic response bec...
77 FR 40826 - Airworthiness Directives; Bombardier, Inc. Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-11
... Bombardier, Inc., 400 C[ocirc]te-Vertu Road West, Dorval, Qu[eacute]bec H4S 1Y9, Canada; telephone 514-855... information identified in this AD, contact Bombardier, Inc., 400 C[ocirc]te-Vertu Road West, Dorval, Qu[eacute...
Evaluation/modification of IDOT foundation piling design and construction policy.
DOT National Transportation Integrated Search
2009-03-01
The Illinois Department of Transportation (IDOT) estimates pile lengths based on a static analysis method; : however, the final length of the pile is determined with a dynamic formula based on the pile driving resistance : exhibited in the field. Bec...
Soil water sensor response to bulk electrical conductivity
USDA-ARS?s Scientific Manuscript database
Soil water monitoring using electromagnetic (EM) sensors can facilitate observations of water content at high temporal and spatial resolutions. These sensors measure soil dielectric permittivity (Ka) which is largely a function of volumetric water content. However, bulk electrical conductivity BEC c...
Universality in quantum chaos and the one-parameter scaling theory.
García-García, Antonio M; Wang, Jiao
2008-02-22
The one-parameter scaling theory is adapted to the context of quantum chaos. We define a generalized dimensionless conductance, g, semiclassically and then study Anderson localization corrections by renormalization group techniques. This analysis permits a characterization of the universality classes associated to a metal (g-->infinity), an insulator (g-->0), and the metal-insulator transition (g-->g(c)) in quantum chaos provided that the classical phase space is not mixed. According to our results the universality class related to the metallic limit includes all the systems in which the Bohigas-Giannoni-Schmit conjecture holds but automatically excludes those in which dynamical localization effects are important. The universality class related to the metal-insulator transition is characterized by classical superdiffusion or a fractal spectrum in low dimensions (d < or = 2). Several examples are discussed in detail.
Social Class and Elite University Education: A Bourdieusian Analysis
ERIC Educational Resources Information Center
Martin, Nathan Douglas
2010-01-01
The United States experienced a tremendous expansion of higher education after the Second World War. However, this expansion has not led to a substantial reduction to class inequalities at elite universities, where the admissions process is growing even more selective. In his classic studies of French education and society, Pierre Bourdieu…
Embracing the Exit: Assessment, Trust, and the Teaching of Writing
ERIC Educational Resources Information Center
Eng, Joseph
2006-01-01
Historically, the Composition Program at Eastern Washington University (EWU), a comprehensive university in Cheney, WA, required a single essay sample from each composition student as the final exit exam; in practice, a student passed or failed the course based on an in-class argumentative essay, written in three consecutive class periods. Such a…
ERIC Educational Resources Information Center
King, Samuel O.; Robinson, Carol L.
2009-01-01
University classes in Mathematics are traditionally perceived to be uninspiring and devoid of active student-lecturer communication. Large undergraduate classes further compound the difficulty of engaging students and enabling viable student-lecturer feedback. At the Mathematics Education Centre, Loughborough University, some staff members have…
Students' Perceptions of the Learning Environment in Tertiary Science Classrooms in Myanmar
ERIC Educational Resources Information Center
Khine, Myint Swe; Fraser, Barry J.; Afari, Ernest; Oo, Zeya; Kyaw, Thein Thein
2018-01-01
We investigated students' perceptions of their science classroom environments with the use of the What Is Happening In this Class? (WIHIC) questionnaire at the university level in Myanmar. The translated questionnaire was administered to 251 students in first-year science classes at a university. Both exploratory factor analysis and confirmatory…
Introduction of Interactive Learning into French University Physics Classrooms
ERIC Educational Resources Information Center
Rudolph, Alexander L.; Lamine, Brahim; Joyce, Michael; Vignolles, Hélène; Consiglio, David
2014-01-01
We report on a project to introduce interactive learning strategies (ILS) to physics classes at the Université Pierre et Marie Curie, one of the leading science universities in France. In Spring 2012, instructors in two large introductory classes, first-year, second-semester mechanics, and second-year introductory electricity and magnetism,…
Incivility among Group Mates in English Classes at a Japanese Women's University
ERIC Educational Resources Information Center
Jacobs, George M.; Kimura, Harumi; Greliche, Nicolas
2016-01-01
Incivilities are words and actions that may be perceived as impolite. This article reports a study of perceptions of and experiences with incivilities during group activities in English class. Participants were 119 students at a women's university in Japan. They completed the Pair/Groupwork Incivility Scale, a Japanese-language instrument, which…
ERIC Educational Resources Information Center
Meekums, Bonnie; Wathen, Cristen C.; Koltz, Rebecca L.
2017-01-01
The purpose of this research was to explore the experience and implementation of a cross-cultural (UK/USA) student videoconference. Participating students were video recorded while participating in a videoconference between a USA University's class Counselling Theories II and a UK University's class, Becoming a Reflective Practitioner 2A. Students…
Easy Implementation of Internet-Based Whiteboard Physics Tutorials
ERIC Educational Resources Information Center
Robinson, Andrew
2008-01-01
The requirement for a method of capturing problem solving on a whiteboard for later replay stems from my teaching load, which includes two classes of first-year university general physics, each with relatively large class sizes of approximately 80-100 students. Most university-level teachers value one-to-one interaction with the students and find…
Winning Is Everything: The Intersection of Academics and Athletics at Prestige University
ERIC Educational Resources Information Center
Clayton, Ashley B.; Grantham, Ashley; McGurrin, Daniel P.; Paparella, Paul; Pellegrino, Lauren N.
2015-01-01
For years, football and basketball players at Prestige University were earning college credit for classes that never existed. The students were enrolled in fake courses, known as "ghost classes," with no formal instruction or required meeting times and requiring only a single term paper. Faculty, staff, and administrators were complicit…
Promoting Interaction through Blogging in Language Classrooms
ERIC Educational Resources Information Center
Gunduz, Muge
2016-01-01
This study aims to explore the university students' perception on integration of blogging in EFL classes. In this study, the participants were first year university students (n=103) who created their group blogs in order to share their blog entries during their oral communication classes. Students interacted with their peers via blogs simply by…
Pedagogical Perspectives on Using Films in Foreign Language Classes. SFC Monograph #4.
ERIC Educational Resources Information Center
Casanave, Christine Pearson, Ed.; Simons, J. David, Ed.
This collection of articles on use of films in second language instruction, particularly for teaching English as a second language (ESL) in Japanese colleges and universities, includes: "Whole Movies and Engaged Response in the Japanese University ESL Classroom" (David P. Shea); "Films in English Class: Going Beyond a Content…
Transitioning an Adult-Serving University to a Blended Learning Model
ERIC Educational Resources Information Center
Korr, Jeremy; Derwin, Ellen Baker; Greene, Kimberly; Sokoloff, William
2012-01-01
While many institutions deliver some classes in blended format, Brandman University transitioned all of its face-to-face classes to blended delivery, using a model tailored to the needs of adult learners. This article provides research supporting the ways that blended learning principles align with key principles of andragogy. The article provides…
Enhancing the Introductory Astronomical Experience with the Use of a Tablet and Telescope
ERIC Educational Resources Information Center
Gill, Robert M.; Burin, Michael J.
2013-01-01
College and university general education (GE) classes are designed to broaden the understanding of all college and university students in areas outside their major interest. However, most GE classes are lecture type and do not facilitate hands-on experimental or observational activities related to the specific subject matter. Utilizing astronomy…
ERIC Educational Resources Information Center
Chakrani, Brahim; Huang, Jason L.
2014-01-01
This article investigates overt language attitudes and linguistic practices among French-taught university students in Morocco, showing the relationship between language behavior and attitudes. The results reveal a class-based divide in respondents' patterns of language use, in their support of the French monolingual sanitized classroom, and in…
"Mooving" to a Virtual Curriculum.
ERIC Educational Resources Information Center
LaRoe, R. John
Three writing classes at the University of Missouri (freshman, sophomore, and senior) spent much or most of the semester on the virtual campus of the Diversity University (DU) MOO (multi-user object oriented). The freshman class wrote one paper on Internet exploration, another on their favorite Internet destination, and for the third were given a…
Widening Participation and the Media Student Experience
ERIC Educational Resources Information Center
Devas, Angela
2011-01-01
Despite an increase in higher education uptake in the UK, participation rates for working class students remain low. When working-class students attend university, they are often attracted to lower status universities to enrol in new subject areas, such as media studies. This study uses Bourdieu's theory of stratification, and its reproduction via…
Collaboration or Cooperation? Analyzing Group Dynamics and Revision Processes in Wikis
ERIC Educational Resources Information Center
Arnold, Nike; Ducate, Lara; Kost, Claudia
2012-01-01
This study examines the online writing and revision behaviors of university language learners. In small groups, 53 intermediate German students from three classes at three different universities created wiki pages with background information about a novel read in class. All meaning- and language-related revisions were analyzed to determine whether…
Labour Universities: Physical Education and the Indoctrination of the Working Class
ERIC Educational Resources Information Center
Delgado-Granados, Patricia; Ramírez-Macías, Gonzalo
2014-01-01
This paper explores the role of physical education in Labour Universities (1955-1978) during Franco's regime as an instrument of indoctrination and declassing of the working class. The conclusions obtained after the study and the analysis of various primary sources indicate that, initially, physical education was used as an instrument of…
ERIC Educational Resources Information Center
Jack, Anthony Abraham
2016-01-01
How do undergraduates engage authority figures in college? Existing explanations predict class-based engagement strategies. Using in-depth interviews with 89 undergraduates at an elite university, I show how undergraduates with disparate precollege experiences differ in their orientations toward and strategies for engaging authority figures in…
[Evaluation of a virtual class on lifelong health care for women].
Park, Jeong Sook; Yang, Jin Hyang
2006-12-01
This study was to evaluate a virtual class, 'lifelong health care for women', for female university students. The research design was one group pre-post design. A pretest and posttest were conducted to measure CMI, perceived health status, health promoting lifestyle, and knowledge related to women's health. The subjects of this study were 74 female students in 3 universities, and they were provided with the virtual class by K university consortium for 16 weeks. Data was analyzed by descriptive and paired t-test. There were statistically significant differences in CMI (t=3.367, p=.001), perceived health status (t=-2.788, p=.007), and knowledge related to women's health (t=-10,432, p=.000) between the pretest and posttest. However, there was not a statistically significant difference in a health promoting lifestyle (t=-1.431, p=.157) between the pretest and posttest. These results suggest that a virtual class on lifelong health care for women is an effective method in decreasing health problems, and improving perceived health status and knowledge related to women's health by female university students.
Two Universality Classes for the Many-Body Localization Transition
NASA Astrophysics Data System (ADS)
Khemani, Vedika; Sheng, D. N.; Huse, David A.
2017-08-01
We provide a systematic comparison of the many-body localization (MBL) transition in spin chains with nonrandom quasiperiodic versus random fields. We find evidence suggesting that these belong to two separate universality classes: the first dominated by "intrinsic" intrasample randomness, and the second dominated by external intersample quenched randomness. We show that the effects of intersample quenched randomness are strongly growing, but not yet dominant, at the system sizes probed by exact-diagonalization studies on random models. Thus, the observed finite-size critical scaling collapses in such studies appear to be in a preasymptotic regime near the nonrandom universality class, but showing signs of the initial crossover towards the external-randomness-dominated universality class. Our results provide an explanation for why exact-diagonalization studies on random models see an apparent scaling near the transition while also obtaining finite-size scaling exponents that strongly violate Harris-Chayes bounds that apply to disorder-driven transitions. We also show that the MBL phase is more stable for the quasiperiodic model as compared to the random one, and the transition in the quasiperiodic model suffers less from certain finite-size effects.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Pihlman, M.; Dirks, D.H.
1990-01-03
The Lawrence Livermore National Laboratory (LLNL) encourages its employees to remotely attend classes given by Stanford University, University of California at Davis, and the National Technological University (NTU). To improve the quality of education for LLNL employees, we are cooperating with Stanford University in upgrading the Stanford Instructional Television Network (SITN). A dedicated high-speed communication link (Tl) between Stanford and LLNL will be used for enhanced services such as videoconferencing, real time classnotes distribution, and electronic distribution of homework assignments. The new network will also allow students to take classes from their offices with the ability to ask the professormore » questions via an automatically dialed telephone call. As part of this upgrade, we have also proposed a new videoconferencing based classroom environment where students taking remote classes would feel as though they are attending the live class. All paperwork would be available in near real time and students may converse normally with, and see, other remote students as though they were all in the same physical location. We call this the Virtual Classroom.'' 1 ref., 6 figs.« less
The NRAO Observing for University Classes Program
NASA Astrophysics Data System (ADS)
Cannon, John M.; Van Moorsel, Gustaaf A.
2017-01-01
The NRAO "Observing for University Classes" program is a tremendous resource for instructors of courses in observational astronomy. As a service to the astronomical and educational communities, the NRAO offers small amounts of observing time on the Very Large Array (VLA) and the Very Long Baseline Array to such instructors. The data can be used by students and faculty to demonstrate radio astronomy theory with modern data products. Further, the results may lead to publication; this is a unique opportunity for faculty members to integrate research into the classroom. Previous experience with NRAO facilities is required for instructors; individuals without radio astronomy experience can take advantage of other NRAO educational opportunities (e.g., the Synthesis Imaging Workshop) prior to using the program. No previous experience with radio astronomy data is required for students; this is the primary target audience of the program. To demonstrate concept, this poster describes three different VLA observing programs that have been completed using the "Observing for University Classes" resource at Macalester College; undergraduate students have published the results of all three of these programs. Other recent "Observing for University Classes" programs are also described.
Constellation Program Design Challenges as Opportunities for Educational Outreach- Lessons Learned
NASA Technical Reports Server (NTRS)
Trevino, Robert C.
2010-01-01
The Texas Space Grant Consortium (TSGC) and the NASA Exploration Systems Mission Directorate (ESMD) Education Office both have programs that present design challenges for university senior design classes that offer great opportunities for educational outreach and workforce development. These design challenges have been identified by NASA engineers and scientists as actual design problems faced by the Constellation Program in its exploration missions and architecture. Student teams formed in their senior design class select and then work on a design challenge for one or two semesters. The senior design class follows the requirements set by their university, but it must also comply with the Accreditation Board for Engineering and Technology (ABET) in order to meet the class academic requirements. Based on a one year fellowship at a TSGC university under the NASA Administrator's Fellowship Program (NAFP) and several years of experience, lessons learned are presented on the NASA Design Challenge Program.
The Influence of Circadian Type, Time of Day and Class Difficulty on Students' Grades
ERIC Educational Resources Information Center
McElroy, Todd; Mosteller, Lynn
2006-01-01
Introduction: In this paper we investigate how students' class grades are affected by individual differences in circadian rhythm, class time-of-day and class difficulty. Method: Using a sample of university students, we assessed morningness and eveningness personality type, and then obtained students recalled classes as well as their…
Gravel, Anne Renée; Riel, Jessica; Messing, Karen
2017-11-01
Women's workplaces should guarantee healthy pregnancies while supporting pregnant women as workers. In Québec (Canada), a pregnant worker exposed to a "danger" for herself or her fetus may ask her employer to be reassigned to other work appropriate to her skills. This approach differs from other regulatory contexts in North America in that protection of fetal and maternal health is embedded in the health and safety legislation. The advantage is that the pregnant worker is guaranteed access to her full salary, but some may question whether specific provisions for pregnant women single out such women and produce risks for their careers or, conversely, pregnancy should receive even more special consideration. These questions are discussed using the results of a qualitative analysis of interviews with pregnant nurses, their supervisors, and their union representatives in ten hospitals in Québec. We think that the management of pregnancy under this legislation generally protects health, but that, in the absence of true employer commitment to the health of all workers, undue burdens may be placed upon other members of the work team. Résumé Les lieux de travail des femmes devraient garantir des grossesses saines tout en soutenant les femmes enceintes en tant que travailleurs. Au Québec (Canada), une travailleuse enceinte exposée à un danger pour elle-même ou son ftus peut demander à son employeur d'être réaffectée à d'autres tãches sans danger et adaptéches à ses compétences. Cette approche diffère des autres contextes réglementaires en Amérique du Nord en ce sens que la protection de la santé foetale et maternelle est intégrée dans la législation sur la santé et la sécurité. Certains peuvent se demander si des dispositions spécifiques pour les femmes enceintes singularisent ces travailleuses et contribuent à la précarisation de leur emploi. Ou, à l'inverse, si la grossesse devrait recevoir une considération encore plus spéciale. Ces questions sont discutées à la lumière du récit d infirmières enceintes, de gestionnaires et de représentants syndicaux responsables des dossiers de conciliation travail-grossesse dans dix hôpitaux du Québec. Nous constatons que la gestion de la grossesse en vertu de cette législation est généralement protectrice de la santé, mais qu'en l'absence d'un véritable engagement de l'employeur envers la santé de tous les travailleurs, des charges excessives peuvent être imposées aux autres membres de l'équipe de travail.
Universal and adapted vocabularies for generic visual categorization.
Perronnin, Florent
2008-07-01
Generic Visual Categorization (GVC) is the pattern classification problem which consists in assigning labels to an image based on its semantic content. This is a challenging task as one has to deal with inherent object/scene variations as well as changes in viewpoint, lighting and occlusion. Several state-of-the-art GVC systems use a vocabulary of visual terms to characterize images with a histogram of visual word counts. We propose a novel practical approach to GVC based on a universal vocabulary, which describes the content of all the considered classes of images, and class vocabularies obtained through the adaptation of the universal vocabulary using class-specific data. The main novelty is that an image is characterized by a set of histograms - one per class - where each histogram describes whether the image content is best modeled by the universal vocabulary or the corresponding class vocabulary. This framework is applied to two types of local image features: low-level descriptors such as the popular SIFT and high-level histograms of word co-occurrences in a spatial neighborhood. It is shown experimentally on two challenging datasets (an in-house database of 19 categories and the PASCAL VOC 2006 dataset) that the proposed approach exhibits state-of-the-art performance at a modest computational cost.
DOT National Transportation Integrated Search
2000-11-09
On Thursday, November 9, 2000, the Benefits, Evaluation and Costs (BEC) Committee of ITS America hosted a workshop entitled International Workshop on ITS Benefits: How Evaluation Results Are Used in Transportation Decision-Making in Turin, Ital...
Gaboury, Isabelle; Johnson, Noémie; Robin, Christine; Luc, Mireille; O'Connor, Daniel; Patenaude, Johane; Pélissier-Simard, Luce; Xhignesse, Marianne
2016-12-01
To determine whether medical training prepares FPs to meet the requirements of the Collège des médecins du Québec for their role in advising patients on the use of complementary and alternative medicine (CAM). Secondary analysis of survey results. Quebec. Family physicians and GPs in active practice. Perceptions of the role of the physician as an advisor on CAM; level of comfort responding to questions and advising patients on CAM; frequency with which patients ask their physicians about CAM; personal position on CAM; and desire for training on CAM. The response rate was 19.5% (195 respondents of 1000) and the sample appears to be representative of the target population. Most respondents (85.8%) reported being asked about CAM several times a month. A similar proportion (86.7%) believed it was their role to advise patients on CAM. However, of this group, only 33.1% reported being able to do so. There is an association between an urban practice and knowledge of the advisory role of physicians. More than three-quarters of respondents expressed interest in receiving additional training on CAM. There is a gap between the training that Quebec physicians receive on CAM and their need to meet legal and ethical obligations designed to protect the public where CAM products and therapies are concerned. One solution might be more thorough training on CAM to help physicians meet the Collège des médecins du Québec requirements. Copyright© the College of Family Physicians of Canada.
Human influenza is more effective than avian influenza at antiviral suppression in airway cells.
Hsu, Alan Chen-Yu; Barr, Ian; Hansbro, Philip M; Wark, Peter A
2011-06-01
Airway epithelial cells are the initial site of infection with influenza viruses. The innate immune responses of airway epithelial cells to infection are important in limiting virus replication and spread. However, relatively little is known about the importance of this innate antiviral response to infection. Avian influenza viruses are a potential source of future pandemics; therefore, it is critical to examine the effectiveness of the host antiviral system to different influenza viruses. We used a human influenza (H3N2) and a low-pathogenic avian influenza (H11N9) to assess and compare the antiviral responses of Calu-3 cells. After infection, H3N2 replicated more effectively than the H11N9 in Calu-3 cells. This was not due to differential expression of sialic acid residues on Calu-3 cells, but was attributed to the interference of host antiviral responses by H3N2. H3N2 induced a delayed antiviral signaling and impaired type I and type III IFN induction compared with the H11N9. The gene encoding for nonstructural (NS) 1 protein was transfected into the bronchial epithelial cells (BECs), and the H3N2 NS1 induced a greater inhibition of antiviral responses compared with the H11N9 NS1. Although the low-pathogenic avian influenza virus was capable of infecting BECs, the human influenza virus replicated more effectively than avian influenza virus in BECs, and this was due to a differential ability of the two NS1 proteins to inhibit antiviral responses. This suggests that the subversion of human antiviral responses may be an important requirement for influenza viruses to adapt to the human host and cause disease.
Barry, Mamadou S; Auger, Nathalie; Burrows, Stephanie
2012-06-01
To determine the age and cause groups contributing to absolute and relative socio-economic inequalities in paediatric mortality, hospitalisation and tumour incidence over time. Deaths (n= 9559), hospitalisations (n= 834,932) and incident tumours (n= 4555) were obtained for five age groupings (<1, 1-4, 5-9, 10-14, 15-19 years) and four periods (1990-1993, 1994-1997, 1998-2001, 2002-2005) for Québec, Canada. Age- and cause-specific morbidity and mortality rates for males and females were calculated across socio-economic status decile based on a composite deprivation score for 89 urban communities. Absolute and relative measures of inequality were computed for each age and cause. Mortality and morbidity rates tended to decrease over time, as did absolute and relative socio-economic inequalities for most (but not all) causes and age groups, although precision was low. Socio-economic inequalities persisted in the last period and were greater on the absolute scale for mortality and hospitalisation in early childhood, and on the relative scale for mortality in adolescents. Four causes (respiratory, digestive, infectious, genito-urinary diseases) contributed to the majority of absolute inequality in hospitalisation (males 85%, females 98%). Inequalities were not pronounced for cause-specific mortality and not apparent for tumour incidence. Socio-economic inequalities in Québec tended to narrow for most but not all outcomes. Absolute socio-economic inequalities persisted for children <10 years, and several causes were responsible for the majority of inequality in hospitalisation. Public health policies and prevention programs aiming to reduce socio-economic inequalities in paediatric health should account for trends that differ across age and cause of disease. © 2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
Maziade, Pierre-Jean; Marcoux, J André
1997-01-01
Une étude rétrospective a été faite dans le but de réviser l’épidémiologie, les facteurs de risque, les manifestations cliniques et l’évolution des cas d’infection à Listeria monocytogenes en Estrie, Québec de 1976–1995. Les patients ont été repérés à partir des cultures positives et du diagnostic donné par le Service des maladies infectieuses du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Québec. Un total de 12 patients ont fait partie de l’étude. La septicémie non reliée à la grossesse (4/12) et la méningite (6/12) ont été les deux présentations cliniques majeures. Il y avait 1 cas de listériose de grossesse et 1 cas de granulomatosis infanti septica. Dix patients avaient au moins une condition prédisposante. Un seul décès a été attribué à l’infection à L monocytogenes. Des séquelles neurologiques ont été observées chez la moitié des patients avec méningite tandis qu’aucune séquelle a été notée chez ceux avec septicémie. En conclusion, la listériose est une maladie de patients âgés et immunocompromis. La présentation clinique et l’évolution ne sont pas différentes de ce qui a déjà été rapporté dans d’autres régions industrialisées. PMID:22514474
Xiang, Zhao; Liang, Zhang; Yanfeng, Huang; Leitao, Kang
2017-10-01
Nodal may play an important role in the development of cancers. The present study was designed to determine the effects of Nodal induced by respiratory syncytial virus (RSV) infection on the occurrence and development of lung cancer and the underlying mechanisms. After verification of RSV infection by observation of cytopathic effect and indirect immunofluorescence, real-time PCR, Western blot and methylation assays were used to verify the influence of RSV on Nodal expression. Then, a Nodal overexpressed vector was constructed and the effects of Nodal on the proliferation and apoptosis of bronchial epithelial cells (BECs) and epithelial-mesenchymal transition (EMT) were assayed by flow cytometry and Western blot, respectively. Moreover, Lefty and pSmad2/3 were assayed by Western blot and Cyclin D1, CDK4, c-myc and Bcl-2 induced by Nodal overepression or RSV infection were also assayed by real-time PCR. The results showed that Nodal over expression and demethylation of the promoter were observed in BECs after RSV infection. Activation of Nodal promoted proliferation, colony formation and EMT and inhibited apoptosis of BECs. Nodal also promoted malignant change by promoting expression of cyclin D1 and related-dependent kinase and inhibiting apoptosis. Besides, RSV infection inhibited Lefty expression and promoted the activation of pSmad2/3. RSV also promoted Cyclin D1, CDK4, c-myc and Bcl-2 expression through the activation of pSmad2/3. Our data showed that persistence of RSV promoted the proliferation, epithelial-mesenchymal transition and expression of oncogenes through Nodal signaling, which may be associated with the occurrence and development of lung cancers.
Zhao, Yingxin; Jamaluddin, Mohammad; Zhang, Yueqing; Sun, Hong; Ivanciuc, Teodora; Garofalo, Roberto P.; Brasier, Allan R.
2017-01-01
Lower respiratory tract infections (LRTIs) from Respiratory Syncytial Virus (RSV) are due, in part, to secreted signals from lower airway cells that modify immune response and trigger airway remodeling. To understand this process, we applied an unbiased quantitative proteomics analysis of the RSV-induced epithelial secretory response in cells representative of the trachea (hBECs) vs small airway bronchiolar cells (hSAECs). A workflow was established using telomerase- immortalized human epithelial cells that revealed highly reproducible cell type-specific differences in both secreted proteins and nanoparticles (exosomes). Approximately one-third of secretome proteins are exosomal, with the remainder from lysosomal and vacuolar compartments. We applied this workflow to three independently derived primary human cultures from trachea (phBECs) vs bronchioles (phSAECs). 577 differentially expressed proteins from control supernatants and 966 differentially expressed proteins from RSV-infected cell supernatants were identified at a 1% false discovery rate (FDR). Fifteen proteins unique to RSV-infected phBECs were regulated by epithelial-specific ets homology factor (EHF). 106 proteins unique to RSV-infected hSAECs were regulated by the transcription factor NFκB. In this latter group, we validated the differential expression of Chemokine (C-C Motif) Ligand 20 (CCL20)/macrophage-inducible protein (MIP)3α, thymic stromal lymphopoietin (TSLP) and chemokine (CC) ligand 3-like 1(CCL3-L1) because of their roles in Th2 polarization. CCL20/MIP3α was the most active mucin-inducing factor in the RSV-infected hSAEC secretome, and was differentially expressed in smaller airways in a mouse model of RSV infection. These studies provide insights into the complexity of innate responses, and regional differences in epithelial secretome participating in RSV LRTI-induced airway remodeling. PMID:28258195