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Sample records for bergsj amer cati

  1. Lobomycosis in Colombian Amer Indian patients.

    PubMed

    Rodríguez-Toro, G; Tellez, N

    1992-10-01

    Several foci of lobomycosis among Colombian Amer Indians population were described in the Casanare region of Colombia, near the Orinoco river on the Colombian-Venezuelan border. This paper reports 16 new patients. The prevalence of Lobo's disease was 8.5% in the Amoruas tribe. Nodular lesions were located on the elbow, scapular and lumbar regions, knees, feet and legs. Leg lesions were especially numerous, were confluent and tended to ulcerate. All cases were confirmed histologically. Two Negro patients were also described. The cases bring the total number of confirmed patients with lobomycosis in Colombia to 41. Twenty-five of these were Amer Indian patients from tribes living in the Orinoco and Amazon basins of the country.

  2. AmerHis: the first switchboard in space

    NASA Astrophysics Data System (ADS)

    Wittig, Manfred; Petz, Felix; Zeppenfeldt, Frank; Pirio, Stephane; Davis, Ian; Balley, Jean-Pierre; Casas, Jose Maria; Pallaschke, Siegmar; Hapgood, Mike

    2005-02-01

    AmerHis is an advanced satellite communication system based around Alcatel's 9343 DVB On-Board Processor. The technology offered by AmerHis provides the means to help to bridge the digital divide in developing regions of the world, with a special emphasis on institutional applications such as telemedicine.

  3. CATIE: Tropical Agricultural Research and Higher Education Center. http://www.catie.ac.cr

    ERIC Educational Resources Information Center

    Applied Environmental Education and Communication, 2004

    2004-01-01

    This article features CATIE (Centro Agronomico Tropical de Investigacion y Ensenanza), a tropical agricultural research and higher education center. CATIE's mission is to be instrumental in poverty reduction and rural development in the American tropics, by promoting diversified and competitive agriculture and sustainable management of natural…

  4. CATIE: Tropical Agricultural Research and Higher Education Center. http://www.catie.ac.cr

    ERIC Educational Resources Information Center

    Applied Environmental Education and Communication, 2004

    2004-01-01

    This article features CATIE (Centro Agronomico Tropical de Investigacion y Ensenanza), a tropical agricultural research and higher education center. CATIE's mission is to be instrumental in poverty reduction and rural development in the American tropics, by promoting diversified and competitive agriculture and sustainable management of natural…

  5. Lace plant ethylene receptors, AmERS1a and AmERS1c, regulate ethylene-induced programmed cell death during leaf morphogenesis.

    PubMed

    Rantong, Gaolathe; Evans, Rodger; Gunawardena, Arunika H L A N

    2015-10-01

    The lace plant, Aponogeton madagascariensis, is an aquatic monocot that forms perforations in its leaves as part of normal leaf development. Perforation formation occurs through developmentally regulated programmed cell death (PCD). The molecular basis of PCD regulation in the lace plant is unknown, however ethylene has been shown to play a significant role. In this study, we examined the role of ethylene receptors during perforation formation. We isolated three lace plant ethylene receptors AmERS1a, AmERS1b and AmERS1c. Using quantitative PCR, we examined their transcript levels at seven stages of leaf development. Through laser-capture microscopy, transcript levels were also determined in cells undergoing PCD and cells not undergoing PCD (NPCD cells). AmERS1a transcript levels were significantly lower in window stage leaves (in which perforation formation and PCD are occurring) as compared to all other leaf developmental stages. AmERS1a and AmERS1c (the most abundant among the three receptors) had the highest transcript levels in mature stage leaves, where PCD is not occurring. Their transcript levels decreased significantly during senescence-associated PCD. AmERS1c had significantly higher transcript levels in NPCD compared to PCD cells. Despite being significantly low in window stage leaves, AmERS1a transcripts were not differentially expressed between PCD and NPCD cells. The results suggested that ethylene receptors negatively regulate ethylene-controlled PCD in the lace plant. A combination of ethylene and receptor levels determines cell fate during perforation formation and leaf senescence. A new model for ethylene emission and receptor expression during lace plant perforation formation and senescence is proposed.

  6. Mona M. Amer: APA/APAGS award for distinguished graduate student in professional psychology.

    PubMed

    2006-11-01

    Presents the citation of Mona M. Amer, who received the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology "for her outstanding and innovative leadership in addressing the mental health needs of Muslim and Arab Americans." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved).

  7. Exome sequencing reveals AMER1 as a frequently mutated gene in colorectal cancer

    PubMed Central

    Sanz-Pamplona, Rebeca; Lopez-Doriga, Adriana; Paré-Brunet, Laia; Lázaro, Kira; Bellido, Fernando; Alonso, M. Henar; Aussó, Susanna; Guinó, Elisabet; Beltrán, Sergi; Castro-Giner, Francesc; Gut, Marta; Sanjuan, Xavier; Closa, Adria; Cordero, David; Morón-Duran, Francisco D.; Soriano, Antonio; Salazar, Ramón; Valle, Laura; Moreno, Victor

    2015-01-01

    PURPOSE Somatic mutations occur at early stages of adenoma and accumulate throughout colorectal cancer (CRC) progression. The aim of this study was to characterize the mutational landscape of stage II tumors and to search for novel recurrent mutations likely implicated in CRC tumorigenesis. DESIGN The exomic DNA of 42 stage II, microsatellite stable, colon tumors and their paired mucosae were sequenced. Other molecular data available in the discovery dataset (gene expression, methylation, and CNV) was used to further characterize these tumors. Additional datasets comprising 553 CRC samples were used to validate the discovered mutations. RESULTS As a result, 4,886 somatic single nucleotide variants (SNVs) were found. Almost all SNVs were private changes, with few mutations shared by more than one tumor, thus revealing tumor-specific mutational landscapes. Nevertheless, these diverse mutations converged into common cellular pathways such as cell cycle or apoptosis. Among this mutational heterogeneity, variants resulting in early stop-codons in the AMER1 (also known as FAM123B or WTX) gene emerged as recurrent mutations in CRC. Loses of AMER1 by other mechanisms apart from mutations such as methylation and copy number aberrations were also found. Tumors lacking this tumor suppressor gene exhibited a mesenchymal phenotype characterized by inhibition of the canonical Wnt pathway. CONCLUSION In silico and experimental validation in independent datasets confirmed the existence of functional mutations in AMER1 in approximately 10% of analyzed CRC tumors. Moreover, these tumors exhibited a characteristic phenotype. PMID:26071483

  8. Impact of the CATIE findings on state mental health policy.

    PubMed

    Parks, Joseph J; Radke, Alan Q; Tandon, Rajiv

    2008-05-01

    The authors, who are medical directors of three state mental health agencies and members of the Medical Directors' Council of the National Association of State Mental Health Program Directors (NASMHPD), describe the impact on public mental health policy of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). Before publication of the CATIE results, the preponderance of information indicated substantial and broad-ranging advantages of second-generation antipsychotics over first-generation agents. State mental health authorities focused on improving access to and increasing utilization of the newer agents. In many states, expenditures for these agents accounted for 10% of the total pharmacy budget of the Medicaid program. After CATIE, state policy makers have had to take a more critical look at the data and formulate more nuanced approaches. The authors summarize policy recommendations of the NASMHPD Medical Directors' Council, which reviewed efficacy studies of antipsychotics and formulated a position statement. The recommendations cover three broad areas of policy. First, neither complete open access for all patients at all times nor a uniform fail-first trial of a first-generation antipsychotic is an optimal approach. A more nuanced middle ground is necessary. Second, excessive emphasis on the cost of second-generation antipsychotics has led to a lack of focus on optimizing use of all antipsychotic medication in usual practice. More research and management attention must be focused on improving how these medications are prescribed for individual patients. Third, more resources should be invested in clinical trials that more clearly and accurately reflect current practice.

  9. Child Attitude Toward Illness Scale (CATIS): A systematic review of the literature.

    PubMed

    Ramsey, Rachelle R; Ryan, Jamie L; Fedele, David A; Mullins, Larry L; Chaney, John M; Wagner, Janelle L

    2016-06-01

    The objective of this study was to systematically review the literature utilizing the Child Attitude Toward Illness Scale (CATIS) as a measure of illness attitudes within pediatric chronic illness, including epilepsy, and provide recommendations for its use. This review includes an examination of the psychometric properties of the CATIS and the relationship between the CATIS and psychological, academic, behavioral, and illness variables. Electronic searches were conducted using Medline and PsychINFO to identify twenty-two relevant publications. The CATIS was identified as a reliable and valid self-report assessment tool across chronic illnesses, including pediatric epilepsy. Although originally developed for children ages 8-12, the CATIS has demonstrated reliability and validity in youth ages 8-22. The CATIS scores were reliably associated with cognitive appraisal variables and internalizing symptoms. Initial support exists for the relation between illness attitudes and externalizing behavior, academic functioning, and psychosocial care needs. Mixed findings were reported with regard to the relation between illness attitudes and demographic and disease variables, as well as both social and family functioning. The CATIS is a psychometrically sound self-report instrument for measuring illness attitudes and demonstrates clinical utility for examining adjustment outcomes across chronic illnesses, particularly pediatric epilepsy. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Behavioural changes and muscle strength in Rattus norvegicus experimentally infected with Toxocara cati and T. canis.

    PubMed

    Santos, S V; Moura, J V L; Lescano, S A Z; Castro, J M; Ribeiro, M C S A; Chieffi, P P

    2015-07-01

    Toxocara canis and Toxocara cati are nematode parasites in dogs and cats, respectively, transmitted by ingestion of embryonated eggs, transmammary and transplacental (T. canis) routes and paratenic host predation. Many parasites use mechanisms that change the behaviour of their hosts to ensure continued transmission. Several researchers have demonstrated behavioural changes in mouse models as paratenic hosts for T. canis. However, there have been no studies on behavioural changes in laboratory rats (Rattus norvegicus) experimentally infected with T. cati. This study investigated behavioural changes and muscle strength in male and female rats experimentally infected with T. cati or T. canis in acute and chronic phases of infection. Regardless of sex, rats infected with T. cati showed a greater decrease in muscle strength 42 days post infection compared to rats infected with T. canis. However, behavioural changes were only observed in female rats infected with T. canis.

  11. Soil radon dynamics in the Amer fault zone: An example of very high seasonal variations.

    PubMed

    Moreno, V; Bach, J; Font, Ll; Baixeras, C; Zarroca, M; Linares, R; Roqué, C

    2016-01-01

    Soil radon levels of the Amer fault zone have been measured for a 4 year-period with the aim of checking seasonal fluctuations obtained in previous studies and to understand radon origin and dynamics. In this manuscript additional results are presented: updated continuous and integrated soil radon measurements, radionuclide content of soil materials and a detailed analysis of an urban profile by means of the electrical resistivity imaging technique and punctual soil radon, thoron and CO2 measurements. Integrated and continuous measurements present a wide range of values, [0.2-151.6] kBq m(-3) for radon, [4.5-39.6] kBq m(-3) for thoron and [4.0-71.2] g m(-2) day(-1) for CO2. The highest soil radon levels in the vicinity of the Amer fault (>40 kBq m(-3)) are found close to the fractured areas and present very important fluctuations repeated every year, with values in summer much higher than in winter, confirming previous studies. The highest radon values, up to 150 kBq m(-3), do not have a local origin because the mean value of radium concentration in this soil (19 ± 5 Bq kg(-1)) could not explain these values. Then soil radon migration through the fractures, influenced by atmospheric parameters, is assumed to account for such a high seasonal fluctuation. As main conclusion, in fractured areas, seasonal variations of soil radon concentration can be very important even in places where average soil radon concentration and radium content are not especially high. In these cases the migration capability of the soil is given not by intrinsic permeability but by the fracture structure. Potential risk estimation based on soil radon concentration and intrinsic permeability must be complemented with geological information in fractured systems.

  12. Sensitivity and specificity of the amer dizziness diagnostic scale (adds) for patients with vestibular disorders.

    PubMed

    Al Saif, Amer; Alsenany, Samira

    2015-01-01

    [Purpose] To investigate the sensitivity and specificity of a newly developed diagnostic tool, the Amer Dizziness Diagnostic Scale (ADDS), to evaluate and differentially diagnose vestibular disorder and to identify the strengths and weaknesses of the scale and its usefulness in clinical practice. [Subjects and Methods] Two hundred subjects of both genders (72 males, 128 females) aged between 18 to 60 (49.5±7.8) who had a history of vertigo and/or dizziness symptoms for this previous two weeks or less were recruited for the study. All subjects were referred by otolaryngologists, neurologists or family physicians in and around Jeddah, Kingdom of Saudi Arabia. On the first clinic visit, all the patients were evaluated once using the ADDS, following which they underwent routine testing of clinical signs and symptoms, audiometry, and a neurological examination, coupled with tests of Vestibulo-Ocular Reflex function, which often serves as the "gold standard" for determining the probability of a vestibular deficit. [Results] The results show that the ADDS strongly correlated with "true-positive" and "true-negative" responses for determining the probability of a vestibular disorder (r =0.95). A stepwise linear regression was conducted and the results indicate that the ADDS was a significant predictor of "true-positive" and "true-negative" responses in vestibular disorders (R(2) =0.90). Approximately 90% of the variability in the vestibular gold standard test was explained by its relationship to the ADDS. Moreover, the ADDS was found to have a sensitivity of 96% and a specificity of 96%. [Conclusion] This study showed that the Amer Dizziness Diagnostic Scale has high sensitivity and specificity and that it can be used as a method of differential diagnosis for patients with vestibular disorders.

  13. Results of Phase 3 of the CATIE Schizophrenia Trial

    PubMed Central

    Stroup, T. Scott; Lieberman, Jeffrey A.; McEvoy, Joseph P.; Davis, Sonia M.; Swartz, Marvin S.; Keefe, Richard S.E.; Miller, Alexander L.; Rosenheck, Robert A.; Hsiao, John K.

    2009-01-01

    Objective The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study examined the comparative effectiveness of antipsychotic treatments for individuals with chronic schizophrenia. Patients who had discontinued antipsychotic treatment in phases 1 and 2 were eligible for phase 3, in which they selected one of nine antipsychotic regimens with the help of their study doctor. We describe the characteristics of the patients who selected each treatment option and their outcomes. Method Two hundred and seventy patients entered phase 3. The open-label treatment options were monotherapy with oral aripiprazole, clozapine, olanzapine, perphenazine, quetiapine, risperidone, ziprasidone, long-acting injectable fluphenazine decanoate, or a combination of any two of these treatments. Results Few patients selected fluphenazine decanoate (n=9) or perphenazine (n=4). Similar numbers selected each of the other options (range 33–41). Of the seven common choices, those who selected clozapine and combination antipsychotic treatment were the most symptomatic, and those who selected aripiprazole and ziprasidone had the highest body mass index. Symptoms improved for all groups, although the improvements were modest for the groups starting with relatively mild levels of symptoms. Side effect profiles of the medications varied considerably but medication discontinuations due to intolerability were rare (7% overall). Conclusions Patients and their doctors made treatment selections based on clinical factors, including severity of symptoms, response to prior treatments, and physical health status. Fluphenazine decanoate was rarely used among those with evidence of treatment non-adherence and clozapine was underutilized for those with poor previous response. Combination antipsychotic treatment warrants further study. PMID:19027269

  14. Differential serodiagnostics of Toxocara canis and Toxocara cati--is it possible?

    PubMed

    Poulsen, C S; Skov, S; Yoshida, A; Skallerup, P; Maruyama, H; Thamsborg, S M; Nejsum, P

    2015-04-01

    One of the most common zoonotic helminth infections is caused by species in the genus Toxocara, particularly Toxocara canis and T. cati (Syn. T. mystax). However, their relative contribution to toxocarosis in humans remains largely unknown because causative larvae are seldom recovered and uncertainties regarding the validity of existing serological assays. In this study, we used sera from a pig model experimentally infected with T. canis and T. cati to evaluate whether a Western blot could discriminate between the two species. No proteins were observed that could be used as a diagnostic tool. In addition, a heterogenic protein pattern between individual hosts was found, which was most pronounced in the T. cati-infected pigs. There is therefore an urgent need to optimize and validate current methods or develop new species-specific serological methods in order to implement appropriate control measures.

  15. Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis.

    PubMed

    Janecek, Elisabeth; Waindok, Patrick; Bankstahl, Marion; Strube, Christina

    2017-05-01

    Neuroinvasive larvae of the worldwide occurring zoonotic roundworms Toxocara canis and T. cati may induce neurotoxocarosis (NT) in humans, provoking a variety of symptoms including cognitive deficits as well as neurological dysfunctions. An association with neuropsychological disorders has been discussed. Similar symptoms have been described in T. canis-infected mice, whereas data on T. cati-induced NT are rare. Therefore, it was aimed to obtain insights into the impact on neurobehaviour as well as progression of neurological symptoms and behavioural alterations during the course of NT directly comparing T. canis- and T. cati-infected mice as models for human NT. C57BL/6 mice were orally infected with 2000 embryonated T. canis or T. cati eggs, respectively, the control group received tap water. Mice were screened weekly for neurobehavioural alterations and memory function starting one day prior infection until 97 days post infection (pi; T. canis-infection) and day 118 pi (T. cati-infection, uninfected control). Mostly motoric and neurological parameters were affected in T. canis-infected mice starting day 20 pi with severe progression accompanied by stereotypical circling. In contrast, T. cati-infected mice mostly showed reduced response to sudden sound stimulus (indicator for excitability) and flight behaviour starting day 6 pi. Interestingly, enhanced grooming behaviour was observed exclusively in T. cati-infected mice, indicating a possible role of neurotransmitter dysregulation. Reduced exploratory behaviour and memory impairment was observed in both infection groups with delayed onset and less severe progression in T. cati- compared to T. canis-infected mice. Results highlight the need to consider T. cati beside T. canis as causative agent of human NT. Findings provide valuable hints towards differences in key regulatory mechanisms during T. canis- and T. cati-induced NT, contributing to a comprehensive picture and consequently a broader understanding of NT

  16. First report of Toxocara cati in the domestic land snail Rumina decollata.

    PubMed

    Cardillo, Natalia; Prous, Cintia Gonzalez; Krivokapich, Silvio; Pittaro, Mariana; Ercole, Mariano; Perez, Matías; Pasqualetti, Mariana; Fariña, Fernando; Rosa, Adriana; Gatti, Graciana; Ribicich, Mabel

    The prospective role of the land snail Rumina decollata as a potential paratenic host of Toxocara cati for domestic cats was studied. R. decollata specimens and cats' feces were collected from the open spaces of a Buenos Aires city hospital. Cats' feces were analyzed and snails were digested to identify T. cati stages, by morphological and molecular analyses. T. cati larval eggs were recovered from 23.5% (4/17) of the sampled feces. Twenty percent of snail pools (5/25) were confirmed to be positive for Toxocara spp. third larval stage (L3) by PCR. The mean value of total larvae recovered per gram of snail in all positive pools was 5.1, with a maximum 33 L3/pool. This is the first report of T. cati infective larvae in R. decollata domestic snail as a paratenic host, since the relationship between infection in snails and in cats' feces could be demonstrated in a common environment. Copyright © 2016 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Toxocara cati (Nematoda: Ascarididae) in Didelphis albiventris (Marsupialia: Didelphidae) from Brazil: a case of pseudoparasitism.

    PubMed

    Pinto, Hudson Alves; Mati, Vitor Luís Tenório; Melo, Alan Lane de

    2014-01-01

    Eggs of Toxocara cati were found in the feces of Didelphis albiventris from a peridomestic urban environment in Brazil. Negative fecal tests following short-term captivity of the opossums, as well as the absence of ascaridids during necropsy, suggest the occurrence of pseudoparasitism. Implications of the findings for the epidemiology of toxocariasis are discussed.

  18. Comparison of outcomes for African Americans, Hispanics, and Non-Hispanic Whites in the CATIE study.

    PubMed

    Arnold, Jodi Gonzalez; Miller, Alexander L; Cañive, José M; Rosenheck, Robert A; Swartz, Marvin S; Mintz, Jim

    2013-06-01

    Medication outcome literature in schizophrenia across racial-ethnic groups is sparse, with inconsistent findings. The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study provided an opportunity for exploratory analyses of racial-ethnic outcomes. The study objective was to examine race-ethnicity outcomes for CATIE's main outcome (study discontinuation) and secondary outcomes. CATIE participants included whites (non-Hispanic) (N=722), African Americans (N=506), and Hispanics (N=170). Survival analyses and mixed-effects regression modeling were conducted, with adjustment for baseline sociodemographic differences and baseline scores of the secondary outcomes. Racial-ethnic groups had unique patterns of outcomes. Hispanics were much more likely to discontinue for lack of efficacy from perphenazine (64% versus 42% non-Hispanic whites and 24% African Americans) and ziprasidone (71% versus 40% non-Hispanic whites and 24% African Americans); Hispanics' quality of life also declined on these medications. Non-Hispanic whites were more likely to discontinue for lack of efficacy in general (averaging olanzapine, quetiapine, and risperidone discontinuation rates). African Americans were less likely to continue after the first phase (32% continuing versus 40% for non-Hispanic whites and 41% Hispanics). Discontinuations were driven by research burden, personal issues, and unspecified loss to follow-up. Non-Hispanic whites had higher depression scores during the follow-up period. African Americans had fewer side effects. CATIE results did not show disparities favoring non-Hispanic whites. CATIE may have provided state-of-the-art treatment and thus reduced disparate treatments observed in community clinics. African Americans discontinued even after consideration of socioeconomic differences. Why perphenazine and ziprasidone may be less effective with Hispanics should be explored.

  19. Implementing a computer-assisted telephone interview (CATI) system to increase colorectal cancer screening: a process evaluation.

    PubMed

    White, Mary Jo; Stark, Jennifer R; Luckmann, Roger; Rosal, Milagros C; Clemow, Lynn; Costanza, Mary E

    2006-06-01

    Computer-assisted telephone interviewing (CATI) systems used by telephone counselors (TCs) may be efficient mechanisms to counsel patients on cancer and recommended preventive screening tests in order to extend a primary care provider's reach to his/her patients. The implementation process of such a system for promoting colorectal (CRC) cancer screening using a computer-assisted telephone interview (CATI) system is reported in this paper. The process evaluation assessed three components of the intervention: message production, program implementation and audience reception. Of 1181 potentially eligible patients, 1025 (87%) patients were reached by the TCs and 725 of those patients (71%) were eligible to receive counseling. Five hundred eighty-two (80%) patients agreed to counseling. It is feasible to design and use CATI systems for prevention counseling of patients in primary care practices. CATI systems have the potential of being used as a referral service by primary care providers and health care organizations for patient education.

  20. Occurrence of Thelazia callipaeda and Toxocara cati in an imported European lynx (Lynx lynx) in Japan.

    PubMed

    El-Dakhly, Khaled; Abo El-Hadid, Shawky; Shimizu, Hirofumi; El-Nahass, Shaymaa; Murai, Atsuko; Sakai, Hiroki; Yanai, Tokuma

    2012-09-01

    A necropsy was performed on an adult European lynx, Lynx lynx (Linnaeus, 1758), held in captivity until its death, to determine level of parasitism. Examination of the eyes revealed the oriental eyeworm, Thelazia callipaeda, in the conjunctival sac and the third eyelid of both eyes. The species was confirmed by location and morphology. Intact worms were fixed, mounted, and identified. Examination of the alimentary tract revealed the common ascaroid nematode, Toxocara cati. Species was confirmed by the arrow-like anterior end. One hundred and forty-one adult worms were collected. The presence of these nematodes indicated the importance of eliminating the contact of zoo animals with Amiota spp. vectors and to prevent contamination with the infective T. cati eggs.

  1. The effects of benzimidazoles on the larval stage of Toxocara cati in experimentally infected chickens.

    PubMed

    Oryan, A; Sadjjani, S M; Azizi, S

    2009-04-01

    Toxocara cati (T. cati) and Toxocara canis (T. canis), roundworms of cats and dogs, are zoonotic parasites that cause visceral and ocular larval migrans in human beings. Humans and other paratenic hosts are infected by ingesting the infective Toxocara eggs from contaminated soil, unwashed hands, contaminated raw vegetables or ingestion of under-cooked organs and muscle tissues of infected paratenic hosts such as chickens, cattle and sheep. It has been shown that the seroprevalence of toxocariasis in the rural and urban children of southern Iran is high and more than 50% of cats of this area are also infected with T. cati. It is stated that consumption of raw chicken meat resulted in visceral toxocariasis. It is possible that poultry reared outdoors and feeding in open range system, gain Toxocara eggs from soil and or by eating infected earthworms as paratenic host. The aim of the present study was to investigate the effects of albendazole and febendazole in experimentally infected chickens with eggs of T. cati by histopathological and digestive methods. Pathologic lesions were observed only in the untreated group and larvae were detected in brain of 3 chickens of this group by squash method. No larva was observed at histopathological level in liver, lungs, brain, cardiac and skeletal muscles and other examined organs of either treated or untreated animals. No lesion was seen in other tissues of the infected untreated chickens. Treatment resulted in disappearance of the larvae and disappearance of the gross and histopathologic abnormalities from their organs. No detectable difference was observed in chemosusceptibility of the two drugs.

  2. Experimental infection with Toxocara cati in pigs: migratory pattern and pathological response in early phase.

    PubMed

    Sommerfelt, Irma Estela; Duchene, Adriana; Daprato, Betina; Lopez, Clara María; Cardillo, Natalia; Franco, Aníbal Juan

    2014-01-01

    Experimental inoculations of approximately 100,000 infective Toxocara cati larval eggs were done in twelve pigs. The T. cati eggs used for inoculation were collected from cat's feces. Another group of three pigs served as an uninfected control. Groups of infected pigs were euthanized at seven, 14, 21, and 28 days post-inoculation (dpi). Tissue samples were taken for digestion and histopathology changes in early phase. The number of larvae recovered from the lungs peaked at seven and 14 dpi and were also present at 21, and 28 dpi. Larvae of T. cati were present in the lymph nodes of the small and large intestine at seven, 14, and 28 dpi and at seven, 14, 21, and 28 dpi respectively. In other studied tissues, no larvae or less than one larva per gram was detected. The pathological response observed in the liver and lungs at seven and 14 dpi, showed white spots on the liver surface and areas of consolidation were observed in the lungs. The lungs showed an inflammatory reaction with larvae in center at 28 dpi. In the liver we observed periportal and perilobular hepatitis. The lymph nodes of the intestines displayed eosinophil lymphadenitis with reactive centers containing parasitic forms in some of them. The granulomatous reaction was not observed in any tissues. The role of the other examined tissues had less significance. The relevance of this parasite as an etiological agent that leads to disease in paratenic hosts is evident.

  3. High infectivity of Toxocara cati larvae from muscles of experimentally infected rats.

    PubMed

    Taira, Kensuke; Yanagida, Tomonori; Akazawa, Naoko; Saitoh, Yasuhide

    2013-09-23

    The organ distribution of Toxocara cati larvae in albino rats Rattus norvegicus (n=6/group) experimentally inoculated with 1000 embryonated eggs was examined 1, 2, 3, 7, 30, 90, and 180 days post inoculation (dpi), and the infectivity of recovered larvae was evaluated by bioassay in mice. The intestines, liver, lungs, muscles (carcass) and other organs (heart, brain, spleen, kidneys and genital organs) were digested for larval recovery. Larvae were recovered from all rats, with the mean number of recovered larvae ranging from 13.3 at 1 dpi to 135.6 at 90 dpi. Most of the larvae recovered were detected in the intestines (56.3%) and liver (43.8%) at 1 dpi; liver (21.6%) and lungs (69.6%) at 2 dpi; muscles (45.9%) and lungs (36.9%) at 3 dpi. Subsequently, most of larvae were recovered from muscles at 7 dpi (92.5%), 30 dpi (97.8%), 90 dpi (99.4%) and 180 dpi (99.1%). In the mouse bioassay, 43.8% of 90-day-old larvae and 43.0% of 180-day-old larvae recovered from rats established in mice. The present study demonstrated that T. cati larvae persist predominantly in rat muscles and nearly half of them retain infective for at least half a year. The results indicate that R. norvegicus may be a suitable paratenic host of T. cati under natural conditions.

  4. Contamination, distribution and pathogenicity of Toxocara canis and T. cati eggs from sandpits in Tokyo, Japan.

    PubMed

    Macuhova, K; Akao, N; Fujinami, Y; Kumagai, T; Ohta, N

    2013-09-01

    The contamination, distribution and pathogenicity of Toxocara canis and T. cati eggs in sandpits in the Tokyo metropolitan area, Japan, are described. A total of 34 sandpits were examined, 14 of which were contaminated with T. cati eggs, as assessed by the floatation method and polymerase chain reaction (PCR) analysis. Two naturally contaminated sandpits were investigated to determine the vertical and horizontal distribution of eggs, and an inverse relationship between the sand depth and number of eggs was observed. To examine the pathogenicity of the eggs, three ICR mice were inoculated with 300 eggs, which were recovered from sandpits. The mice exhibited eosinophilia in the peripheral blood and IgG antibody production in the sera after 3 weeks of infection. Most migrating larvae were recovered from carcasses, although three were found in the brains of two infected mice. These three larvae were determined to be T. canis by PCR, revealing that not only T. cati, but also T. canis eggs could be found in sandpits and, further, that eggs recovered from sandpits have the ability to invade a paratenic host.

  5. Modified method to enhanced recovery of Toxocara cati larvae for the purposes of diagnostic and therapeutic.

    PubMed

    Zibaei, Mohammad; Uga, Shoji

    2016-10-01

    Human toxocariasis, extraintestinal-migration of Toxocara species, is a worldwide helminthic zoonosis in many places of the undeveloped countries. Toxocara cati is one of the common helminths in cats and it is a potentially preventable disease. Its diagnosis and treatment depend on the demonstration of specific excretory-secretory Toxocara antibodies from Toxocara larvae by immunological assays. This study provides a simple manual technique which can be performed in any laboratory for recovering a large number of Toxocara cati larvae from the thick-shelled eggs. The devices that are required contain a manual homogenizer and a filter membrane of 40 μm mesh; the rest of materials and solutions is standard laboratory ware. In the modified method the larval yields were 2.7 times higher (3000 larval/ml) and the time spent in performing the modified method was shorter (75 min). Further benefits over already techniques are the easy and repeatable, inexpensive and convenient materials, simplicity to perform and require less time for recovery of Toxocara cati larvae for subsequent cultivation and harvest of the larval excretory-secretory antigens for diagnostic or treatment purposes. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. EXPERIMENTAL INFECTION WITH Toxocara cati IN PIGS: MIGRATORY PATTERN AND PATHOLOGICAL RESPONSE IN EARLY PHASE

    PubMed Central

    Sommerfelt, Irma Estela; Duchene, Adriana; Daprato, Betina; Lopez, Clara María; Cardillo, Natalia; Franco, Aníbal Juan

    2014-01-01

    Experimental inoculations of approximately 100,000 infective Toxocara cati larval eggs were done in twelve pigs. The T. cati eggs used for inoculation were collected from cat's feces. Another group of three pigs served as an uninfected control. Groups of infected pigs were euthanized at seven, 14, 21, and 28 days post-inoculation (dpi). Tissue samples were taken for digestion and histopathology changes in early phase. The number of larvae recovered from the lungs peaked at seven and 14 dpi and were also present at 21, and 28 dpi. Larvae of T. cati were present in the lymph nodes of the small and large intestine at seven, 14, and 28 dpi and at seven, 14, 21, and 28 dpi respectively. In other studied tissues, no larvae or less than one larva per gram was detected. The pathological response observed in the liver and lungs at seven and 14 dpi, showed white spots on the liver surface and areas of consolidation were observed in the lungs. The lungs showed an inflammatory reaction with larvae in center at 28 dpi. In the liver we observed periportal and perilobular hepatitis. The lymph nodes of the intestines displayed eosinophil lymphadenitis with reactive centers containing parasitic forms in some of them. The granulomatous reaction was not observed in any tissues. The role of the other examined tissues had less significance. The relevance of this parasite as an etiological agent that leads to disease in paratenic hosts is evident. PMID:25076437

  7. The AMERE project: Enabling real-time detection of radiation effects in individual cells in deep space

    NASA Astrophysics Data System (ADS)

    De Vos, Winnok H.; Meesen, Geert; Szpirer, Cedric; Scohy, Sophie; Cherukuri, Chaitanya; Evrard, Olivier; Hutsebaut, Xavier; Beghuin, Didier

    2012-12-01

    A major concern for long-term deep space missions is the detrimental impact of cosmic radiation on human health. Especially the presence of high-energy particles of high atomic mass (HZE) represents a serious threat. To contribute to a fundamental understanding of space radiation effects and to help improving risk assessment for humans on the Moon, the ESA Lunar Lander mission model payload includes a package dedicated to cell-based radiobiology experiments in the form of an Autonomous Microscope for Examination of Radiation Effects (AMERE). The purpose of this setup is to enable real-time visualization of DNA damage repair in living cells after traversal of HZE particles on the Moon. To assess the feasibility of this challenging experiment, we have analysed the biological and technological demands. In this article, we discuss the experimental concept, the biological considerations and describe the implications for system design.

  8. Flotation and adherence characteristics of Toxocara canis and T. cati and a reliable method for recovering Toxocara eggs from soil.

    PubMed

    Kleine, Annika; Janecek, Elisabeth; Waindok, Patrick; Strube, Christina

    2016-08-30

    Toxocara canis and T. cati are worldwide distributed intestinal nematodes of canids and felids and pose a threat to public health due to possible clinical manifestations in humans. Different methods for detection of Toxocara eggs in soil have been described, but conducted studies deal with egg recovery rates of T. canis or "Toxocara spp." only whereas T. cati egg recovery has not been taken into consideration. Thus, flotation properties in sodium chloride solution and adherence characteristics to different substrates possibly coming into contact with Toxocara eggs before or during purification from soil were evaluated for both, T. canis and T. cati eggs. No significant difference was observed in flotation characteristics, but comparison of adherence properties revealed significantly less adherence of T. cati eggs on almost all evaluated substrates ("sand", side sealed bags, glass beaker, centrifuge tube) and different washing solutions (tap water, Tween(®) 80, Triton™ X-100). Mean adhesion rates of T. cati eggs ranged from 15.9% to 68.9%, those of T. canis eggs from 28.3% to 83.9%. While adherence of T. cati eggs on any substrate was significantly reduced when rinsing with Tween(®) 80 solution, no effect on T. canis eggs could be observed. Generally, Toxocara eggs adhere better on plastic than on glass. Evaluation of a method including only non-hazardous substances for purification of Toxocara eggs from soil resulted in a statistically significant higher recovery rate of T. canis (42.6% recovered eggs) compared to T. cati eggs (30.9% recovered eggs). As these percentages are above average for described methods to recover Toxocara eggs from soil, the presented method is considered reliable for prevalence studies.

  9. Adult Toxocara cati infections in U.S. children: report of four cases.

    PubMed

    Eberhard, M L; Alfano, E

    1998-09-01

    We report four cases of passage of subadult or adult Toxocara cati worms by young children ages 20 months to seven years. Worms were expelled rectally in two cases and in two cases they were vomited. A single worm was passed in two cases, three worms in one case, and 15 worms in the fourth case. All worms that were available for study were identified as T. cati by morphologic criteria, including the arrow-shaped cervical alae and the digitiform shape of the male tail. None of the four children exhibited clinical signs of ocular or visceral larva migrans, and in two cases where serum samples were available, neither child had a titer to Toxocara. These results further the argument that these children acquired the worms through the ingestion of immature worms passed by infected cats, not through the ingestion of infective eggs. Although the children were generally not ill as a result of these unusual infections, it does serve to reinforce the public health issue that potential serious consequences can occur where children have exposure to an environment that has been contaminated with cat feces, or, more specifically, infective eggs, and could become infected with larval forms of Toxocara.

  10. Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample.

    PubMed

    Brandl, E J; Tiwari, A K; Zai, C C; Nurmi, E L; Chowdhury, N I; Arenovich, T; Sanches, M; Goncalves, V F; Shen, J J; Lieberman, J A; Meltzer, H Y; Kennedy, J L; Müller, D J

    2016-08-01

    Antipsychotic-induced weight gain (AIWG) is a common side effect with a high genetic contribution. We reanalyzed genome-wide association study (GWAS) data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) selecting a refined subset of patients most suitable for AIWG studies. The final GWAS was conducted in N=189 individuals. The top polymorphisms were analyzed in a second cohort of N=86 patients. None of the single-nucleotide polymorphisms was significant at the genome-wide threshold of 5x10(-8). We observed interesting trends for rs9346455 (P=6.49x10(-6)) upstream of OGFRL1, the intergenic variants rs7336345 (P=1.31 × 10(-5)) and rs1012650 (P=1.47 × 10(-5)), and rs1059778 (P=1.49x10(-5)) in IBA57. In the second cohort, rs9346455 showed significant association with AIWG (P=0.005). The combined meta-analysis P-value for rs9346455 was 1.09 × 10(-7). Our reanalysis of the CATIE GWAS data revealed interesting new variants associated with AIWG. As the functional relevance of these polymorphisms is yet to be determined, further studies are needed.The Pharmacogenomics Journal advance online publication, 1 September 2015; doi:10.1038/tpj.2015.59.

  11. A comparative histopathology, serology and molecular study, on experimental ocular toxocariasis by Toxocara cati in Mongolian gerbils and Wistar rats.

    PubMed

    Zibaei, Mohammad; Sadjjadi, Seyed Mahmoud; Karamian, Mehdi; Uga, Shoji; Oryan, Ahmad; Jahadi-Hosseini, Seyed Hamidreza

    2013-01-01

    The aim of this study was to compare the performance of three in-house diagnostic tests, that is, histopathology, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR), for the diagnosis after experimental infection with Toxocara cati. Twenty Mongolian gerbils and Wistar rats were divided into ten groups (n = 2/group). Toxocara cati infections were established in Mongolian gerbils and Wistar rats by administering doses of 240 and 2500 embryonated Toxocara cati eggs by gavage, respectively. Tissue sections were stained with Haematoxylin and Eosin and observed under the light microscope. Sera and vitreous fluid collected from separate infected groups were tested against Toxocara cati antigens, for 92 days postinfection. Genomic DNA was extracted from formalin-fixed paraffin-embedded (FFPE) blocks, and aqueous fluids belong to the animals. The histopathology test gave negative results among the groups of animals examined between 5 and 92 days postinfection. The ELISA results showed that anti-Toxocara antibodies have risen between 7 and 61 days postinfection in sera and vitreous fluid in the animals infected, respectively. Analysis of PCR products revealed positive band (660 bp) in the orbital tissue infected Mongolian gerbils at 5 days postinfection. Of the three evaluated methods, the PCR could be recommended for scientific and laboratory diagnoses of toxocariasis in experimentally infected animals.

  12. Detection and molecular characterization of ascarid nematode infection (Toxascaris leonina and Toxocara cati) in captive Asiatic lions (Panthera leo persica).

    PubMed

    Pawar, Rahul Mohanchandra; Lakshmikantan, Uthandaraman; Hasan, Shakir; Poornachandar, Anantula; Shivaji, Sisinthy

    2012-03-01

    The objective of this study was to investigate the ascarid infection in Asiatic lions using scat samples, based on microscopic analysis, PCR amplification of the ITS-2 region of ribosomal DNA and sequence analysis of the amplicons. Microscopic analysis indicated the presence of eggs of Toxascaris leonina in eleven of the sixteen scat samples analysed and in one of these eleven scats eggs of Toxocara cati were also detected. In five of the scats eggs were not detectable. The presence of T. leonina in all the infected samples was also confirmed by PCR amplification of the ITS-2 of ribosomal RNA gene and five of these also showed amplicons corresponding to T. cati, respectively. Toxocara canis infection was not observed in any of the scat samples. Nucleotide sequence analysis of the ITS-2 region indicated 97% to 99% similarity with T. leonina and T. cati, respectively. To our knowledge, this is the first molecular characterization of ascarid infection in captive Asiatic lions from a zoological garden of India. This study also indicates that Asiatic lions are more prone to infection either with T. leonina or T. cati and the parasite is not host specific.

  13. A Toxocara cati eggs concentration method from cats' faeces, for experimental and diagnostic purposes.

    PubMed

    Cardillo, N; Sommerfelt, I; Fariña, F; Pasqualetti, M; Pérez, M; Ercole, M; Rosa, A; Ribicich, M

    2014-09-01

    Toxocariosis is a zoonotic parasite infection worldwide distributed, now considered a neglected disease associated to poverty. For experimental infection in animals and to develop the diagnosis in humans it is necessary to obtain large number of Toxocara spp. larval eggs. Toxocara cati eggs recovered percentage from faeces of infected cats was determined employing a novel egg concentration method. The McMaster egg counting technique and the concentration method were applied on 20 positive cats' sample faeces obtained from naturally infected cats. The mean percentage of eggs recovered by the concentration method was 24.37% higher than the count obtained by McMaster egg counting technique. The main advantage of this method is that it can be obtained a small final volume with a high number of recovered eggs and a good quality inoculum for experimental and diagnostic purposes. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Chemical characterization and biological activity of Macfadyena unguis-cati (Bignoniaceae).

    PubMed

    Duarte, D S; Dolabela, M F; Salas, C E; Raslan, D S; Oliveiras, A B; Nenninger, A; Wiedemann, B; Wagner, H; Lombardi, J; Lopes, M T

    2000-03-01

    Macfadyena unguis-cati (L.) has been widely used in folk medicine as an anti-inflammatory, antimalarial and antivenereal. The purpose of this study was to chemically characterize the main plant components, and to evaluate the biological properties of some of the fractions derived from leaves (MACb) and liana (MACa) of this plant. Chemical characterization allowed the identification of the compounds corymboside, vicenin-2, quercitrin, chlorogenic acid, isochlorogenic acid, lupeol, beta-sitosterol, beta-sitosterylglucoside, allantoin and lapachol. The biological screening of fractions and/or purified substances derived from fractions revealed antitumoral and antitrypanosomal activities in fractions MACa/lapachol and MACb/MACb21, respectively. The anti-lipoxygenase and anti-cyclooxygenase effect seen in fractions MACa and MACb showed a partial correlation with the anti-inflammatory property attributed to this plant.

  15. Toxocara cati larva migrans in domestic pigs--detected at slaughterhouse control in Norway.

    PubMed

    Davidson, Rebecca K; Mermer, Anna; Øines, Øivind

    2012-11-21

    Routine Trichinella meat inspection at the slaughterhouse detected one larva in a pooled batch of 100 pig samples. The larva was sent to the Norwegian Veterinary Institute (NVI) for species identification.Morphological examination revealed that the larva was not Trichinella spp. Molecular analysis was performed. PCR and sequencing of 5S/ITS identified the larva as Toxocara cati. A second round of digests was carried out at the meat inspection laboratory, in smaller batches to try to identify the infected animal. No further larvae were detected and it was not possible to identify which of the 100 animals the larva had come from. This is the first time that Toxocara cati has been reported in slaughterhouse pigs in Norway.Although the infected individual could not be identified, the meat originated from one of six potential farms. A small survey regarding rodent control and cats was sent to each of these farms. Cats had restricted access to food storage areas (two farms reported that cats had access) whilst none of the farms allowed cats into the production housing. Cats were, however, present on all the farms (mostly stray cats of unknown health status). Half of the farms also reported seeing rodents in the pig housing during the previous six months and half reported finding rodents in the feed and straw storage areas. We were unable to narrow down the source of infection - however contamination of food or bedding material, with cat faeces or infected rodents, in addition to the presence of infected rodents in pig housing remain potential routes of infection.

  16. A systematic method for estimating individual responses to treatment with antipsychotics in CATIE

    PubMed Central

    Adkins, Daniel E.; McClay, Joseph; Lieberman, Jeffrey; Sullivan, Patrick F.

    2009-01-01

    Objective In addition to comparing drug treatment groups, the wealth of genetic and clinical data collected in the Clinical Antipsychotic Trials of Intervention Effectiveness study offers tremendous opportunities to study individual differences in response to treatment with antipsychotics. A major challenge, however, is how to estimate the individual responses to treatments. For this purpose, we propose a systematic method that condenses all information collected during the trials in an optimal, empirical fashion. Method Our method comprises three steps. First, we test how to best model treatment effects over time. Next, we screen many covariates to select those that will further improve the precision of the individual treatment effect estimates which, for example, improves power to detect predictors of individual treatment response. Third, Best Linear Unbiased Predictors (BLUPs) of the random effects are used to estimate for each individual a treatment effect based on the model empirically indicated to best fit the data. We illustrate our method for the Positive and Negative Syndrome Scale (PANSS). Results A model assuming it takes on average about 30 days for a treatment to exert an effect that will then remain about the same for the rest of the trial showed the best fit to the data. Of all screened covariates, only two improved the precision of the individual treatment effect estimates. A comparison with more traditional post- minus pre-treatment symptom scores showed that our model based treatment effect estimates were a) more precise because they use all data collected during the trial rather than just two data points, and b) less sensitive to biases created by using the same baseline to calculate multiple treatment effects in CATIE. Conclusions We demonstrate that treatment effects can be estimated in a way that condenses all information collected in an optimal, empirical fashion. We expect the proposed method to be valuable for other clinical outcomes in

  17. Duplex quantitative real-time PCR assay for the detection and discrimination of the eggs of Toxocara canis and Toxocara cati (Nematoda, Ascaridoidea) in soil and fecal samples

    PubMed Central

    2012-01-01

    Background Toxocarosis is a zoonotic disease caused by Toxocara canis (T. canis) and/or Toxocara cati (T. cati), two worldwide distributed roundworms which are parasites of canids and felids, respectively. Infections of humans occur through ingestion of embryonated eggs of T. canis or T. cati, when playing with soils contaminated with dogs or cats feces. Accordingly, the assessment of potential contamination of these areas with these roundworms eggs is paramount. Methods A duplex quantitative real-time PCR (2qPCR) targeting the ribosomal RNA gene internal transcribed spacer (ITS2) has been developed and used for rapid and specific identification of T. canis and T. cati eggs in fecal and soil samples. The assay was set up on DNA samples extracted from 53 adult worms including T. canis, T. cati, T. leonina, Ascaris suum (A. suum) and Parascaris equorum (P. equorum). The assay was used to assess the presence of T. cati eggs in several samples, including 12 clean soil samples spiked with eggs of either T. cati or A. suum, 10 actual soil samples randomly collected from playgrounds in Brussels, and fecal samples from cats, dogs, and other animals. 2qPCR results on dogs and cats fecal samples were compared with results from microscopic examination. Results 2qPCR assay allowed specific detection of T. canis and T. cati, whether adult worms, eggs spiked in soil or fecal samples. The 2qPCR limit of detection (LOD) in spiked soil samples was 2 eggs per g of soil for a turnaround time of 3 hours. A perfect concordance was observed between 2qPCR assay and microscopic examination on dogs and cats feces. Conclusion The newly developed 2qPCR assay can be useful for high throughput prospective or retrospective detection of T.canis and/or T. cati eggs in fecal samples as well as in soil samples from playgrounds, parks and sandpits. PMID:23216873

  18. Influence of land use and meteorological factors on the spatial distribution of Toxocara canis and Toxocara cati eggs in soil in urban areas.

    PubMed

    Gao, Xiang; Wang, Hongbin; Li, Jianxin; Qin, Hongyu; Xiao, Jianhua

    2017-01-15

    Soil which has been contaminated by Toxocara spp. eggs is considered as one of the main infection sources of Toxocariasis in animals and humans. The present study conducted a detailed investigation into the spatial patterns of Toxocara canis (T. canis) and Toxocara cati (T. cati) eggs in soil in urban area of northeastern Mainland China, and assessed the inter-relationships between meteorological factors, land use and the distribution of the Toxocara spp. eggs. Polymerase chain reaction (PCR) was used for the determination of T. canis and T. cati eggs contamination in soil samples. Between April 2014 and May 2015, 9420 soil samples were subjected to PCR examination and 7027 sheep (74.6%) were determined to be positive for T. canis and T. cati eggs. Subsequently, we evaluated the effect of land use, and meteorological factors on the spatial distribution of T. canis and T. cati eggs based on a maximum entropy model. Jackknife analysis revealed that the area of residential land, wood and grass land and precipitation may influence the occurrence of T. canis and T. cati eggs in soil. Our findings indicate that land use and meteorological factors may be important variables affecting transmission of Toxocariasis and should be taken into account in the development of future surveillance programmes for Toxocariasis.

  19. Application and bioactive properties of CaTI, a trypsin inhibitor from Capsicum annuum seeds: membrane permeabilization, oxidative stress and intracellular target in phytopathogenic fungi cells.

    PubMed

    Silva, Marciele S; Ribeiro, Suzanna Ff; Taveira, Gabriel B; Rodrigues, Rosana; Fernandes, Katia Vs; Carvalho, André O; Vasconcelos, Ilka Maria; Mello, Erica Oliveira; Gomes, Valdirene M

    2017-08-01

    During the last few years, a growing number of antimicrobial peptides have been isolated from plants and particularly from seeds. Recent results from our laboratory have shown the purification of a new trypsin inhibitor, named CaTI, from chilli pepper (Capsicum annuum L.) seeds. This study aims to evaluate the antifungal activity and mechanism of action of CaTI on phytopathogenic fungi and detect the presence of protease inhibitors in other species of this genus. Our results show that CaTI can inhibit the growth of the phytopathogenic fungi Colletotrichum gloeosporioides and C. lindemuthianum. CaTI can also permeabilize the membrane of all tested fungi. When testing the inhibitor on its ability to induce reactive oxygen species, an induction of reactive oxygen species (ROS) and nitric oxide (NO) particularly in Fusarium species was observed. Using CaTI coupled to fluorescein isothiocyanate (FITC), it was possible to determine the presence of the inhibitor inside the hyphae of the Fusarium oxysporum fungus. The search for protease inhibitors in other Capsicum species revealed their presence in all tested species. This paper shows the antifungal activity of protease inhibitors such as CaTI against phytopathogenic fungi. Antimicrobial peptides, among which the trypsin protease inhibitor family stands out, are present in different species of the genus Capsicum and are part of the chemical arsenal that plants use to defend themselves against pathogens. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  20. Production of Toxocara cati TES-120 Recombinant Antigen and Comparison with its T. canis Homolog for Serodiagnosis of Toxocariasis.

    PubMed

    Zahabiun, Farzaneh; Sadjjadi, Seyed Mahmoud; Yunus, Muhammad Hafiznur; Rahumatullah, Anizah; Moghaddam, Mohammad Hosein Falaki; Saidin, Syazwan; Noordin, Rahmah

    2015-08-01

    Toxocariasis is a cosmopolitan zoonotic disease caused by the infective larvae of Toxocara canis and T. cati. Diagnosis in humans is usually based on clinical symptoms and serology. Immunoglobulin G (IgG)-enzyme-linked immunosorbent assay kits using T. canis excretory-secretory (TES) larval antigens are commonly used for serodiagnosis. Differences in the antigens of the two Toxocara species may influence the diagnostic sensitivity of the test. In this study, T. cati recombinant TES-120 (rTES-120) was cloned, expressed, and compared with its T. canis homolog in an IgG4-western blot. The diagnostic sensitivity and specificity of T. cati rTES-120 were 70% (33/47) and 100% (39/39), respectively. T. canis rTES-120 showed 57.4% sensitivity and 94.4% specificity. When the results of assays using rTES-120 of both species were considered, the diagnostic sensitivity was 76%. This study shows that using antigens from both Toxocara species may improve the serodiagnosis of toxocariasis.

  1. Production of Toxocara cati TES-120 Recombinant Antigen and Comparison with its T. canis Homolog for Serodiagnosis of Toxocariasis

    PubMed Central

    Zahabiun, Farzaneh; Sadjjadi, Seyed Mahmoud; Yunus, Muhammad Hafiznur; Rahumatullah, Anizah; Moghaddam, Mohammad Hosein Falaki; Saidin, Syazwan; Noordin, Rahmah

    2015-01-01

    Toxocariasis is a cosmopolitan zoonotic disease caused by the infective larvae of Toxocara canis and T. cati. Diagnosis in humans is usually based on clinical symptoms and serology. Immunoglobulin G (IgG)-enzyme-linked immunosorbent assay kits using T. canis excretory–secretory (TES) larval antigens are commonly used for serodiagnosis. Differences in the antigens of the two Toxocara species may influence the diagnostic sensitivity of the test. In this study, T. cati recombinant TES-120 (rTES-120) was cloned, expressed, and compared with its T. canis homolog in an IgG4-western blot. The diagnostic sensitivity and specificity of T. cati rTES-120 were 70% (33/47) and 100% (39/39), respectively. T. canis rTES-120 showed 57.4% sensitivity and 94.4% specificity. When the results of assays using rTES-120 of both species were considered, the diagnostic sensitivity was 76%. This study shows that using antigens from both Toxocara species may improve the serodiagnosis of toxocariasis. PMID:26033026

  2. Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats.

    PubMed

    Reinemeyer, C R; Charles, S D; Buch, J; Settje, T; Altreuther, G; Cruthers, L; McCall, J W; Young, D R; Epe, C

    2005-10-01

    Eleven controlled studies were conducted in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid nematodes Toxocara cati and Toxascaris leonina. Infections were induced by administration of larvated ascarid eggs, and stage-specific efficacy was evaluated by treating cats at scheduled intervals post-inoculation. All studies featured random allocation to treatment groups, placebo-treated control animals and assessment of outcome measures by masked personnel. The product (emodepside+praziquantel topical solution) was 100% effective against mature adults and immature adult T. cati. In addition, it was 96.8% effective against third stage larvae and at least 99.4% effective against fourth stage larvae of T. cati, respectively. Efficacy against mature, immature adult and L4 stages of T. leonina exceeded 93.4%, but regulatory "adequacy of infection" criteria were not met in some studies. No adverse reactions to treatment were noted in cats treated with the emodepside+praziquantel topical solution.

  3. Clinical determinants of life satisfaction in chronic schizophrenia: data from the CATIE study.

    PubMed

    Fervaha, Gagan; Agid, Ofer; Takeuchi, Hiroyoshi; Foussias, George; Remington, Gary

    2013-12-01

    Quality of life is seen as an important outcome variable for patients with schizophrenia. However, the precise definition of this construct varies and has often been used to define health-related domains. The present study sought to focus on global life satisfaction as a key subjective domain and determine its relationship with clinical variables. The study sample included 1437 patients with chronic schizophrenia who participated in the Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE) study. Patients were evaluated with a comprehensive battery of assessments capturing symptoms, cognition and medication side effects, among other variables. Life satisfaction was evaluated with a global self-report item. Greater depressive symptoms were the most robust indicator of worse life satisfaction. Lower life satisfaction was also associated with poorer psychosocial functioning, greater symptoms of anxiety, apathy and more negative attitudes toward medication. Taken together, these variables explained 20% of the variance in life satisfaction scores. Positive symptoms and other medication side effects also negatively influenced life satisfaction scores. These results affirm that clinical variables have an adverse effect on the overall subjective well-being of patients with schizophrenia. The relatively small amount of variance explained, though, argues for a better understanding of those other variables that contribute to life satisfaction. © 2013 Elsevier B.V. All rights reserved.

  4. Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and larval stages of Toxocara cati in cats.

    PubMed

    Knaus, Martin; Baker, Christine F; Reinemeyer, Craig R; Chester, S Theodore; Rosentel, Joseph; Rehbein, Steffen

    2014-04-28

    The efficacy of a novel topical combination of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v), and praziquantel 8.3% (w/v) (BROADLINE(®), Merial) was evaluated against adult and larval Toxocara cati in four controlled studies. All studies included experimentally infected, purpose-bred, short-haired cats. In two studies, 22 or 20 cats harbouring patent infections as confirmed by pre-treatment faecal examination, were included. Within each study, cats were allocated to one of two groups: control or treated. In a further two studies, 30 cats were included in each; cats were allocated to one of three groups: control, treated when T. cati were expected to be either migrating third and/or fourth-stage larvae, or treated when T. cati were expected to be fourth-stage larvae. Cats allocated to the treated groups received a single topical application of the combination product at 0.12 mL/kg bodyweight (10mg fipronil+12 mg (S)-methoprene+0.5mg eprinomectin+10mg praziquantel per kg). For parasite recovery and count, cats were euthanized humanely at different intervals after treatment. In the studies targeting adult T. cati, ascarids were recovered from all controls (range 1-150) while only two worms were isolated from one treated cat. Thus, the efficacy of the novel combination was 99.4% and 100% against adult T. cati. For studies targeting larval T. cati, up to 21 worms were recovered from each of seven or eight of the control cats per study. No T. cati were recovered from the treated cats in two studies, corresponding to 100% efficacy against both, migrating third and/or fourth-stage larvae and luminal fourth-stage larvae. All cats accepted the treatment well and no adverse experiences or other health problems were observed throughout the studies.

  5. Morphological variability of Demodex cati in a feline immunodeficiency virus-positive cat.

    PubMed

    Taffin, Elien R L; Casaert, Stijn; Claerebout, Edwin; Vandekerkhof, Thomas J J; Vandenabeele, Sophie

    2016-12-01

    CASE DESCRIPTION A 17-year-old FIV-positive cat was evaluated because of weight loss during the preceding few months. The cat had a weight loss of 0.5 kg (1.1 lb) during the last month. Because of its FIV-positive status, the cat was confined indoors. CLINICAL FINDINGS A large nonpruritic area of alopecia with hyperpigmentation and comedones was present on the right lateral aspect of the neck. The chin had diffuse alopecia and comedones. Mild alopecia was present on the dorsal aspect of the muzzle. Trichography and microscopic examination of acetate tape imprint preparations and skin scrapings revealed a very morphologically heterogeneous population of Demodex mites. Micrometry of adult mites revealed a broad range of body lengths (92.68 to 245.94 μm), which suggested that as many as 3 Demodex spp might be present in the skin lesions of this cat. TREATMENT AND OUTCOME Owing to its concurrent disease, no treatment was initiated for the demodicosis, and the cat died spontaneously 14 days after the evaluation. Sequence analysis of the 16S rRNA gene of collected mites was performed. Analysis revealed that the 16S rRNA gene sequence of collected mites appeared 100% identical to the Demodex cati 16S rRNA gene sequence deposited in GenBank (JX193759). A similarity of 79.2% and 74.4% was found when the 16S rRNA gene sequence of collected mites was compared with that of Demodex gatoi (JX981921) and Demodex felis (KF052995), respectively. CLINICAL RELEVANCE Demodicosis in cats is often associated with underlying disease. In cats, FIV infection may lead to an altered immune response and induce species polymorphism of Demodex mites.

  6. Longitudinal consent-related abilities among research participants with schizophrenia: Results from the CATIE study

    PubMed Central

    Stroup, T. Scott; Appelbaum, Paul S.; Gu, Hongbin; Hays, Spencer; Swartz, Marvin S.; Keefe, Richard S.E.; Kim, Scott; Manschreck, Theo; Boshes, Roger; McEvoy, Joseph P.; Lieberman, Jeffrey A.

    2011-01-01

    Objective Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a trial they may not be able to judge and protect their interests. If reduced abilities are common or can be predicted, special protections can be targeted appropriately. Method We examined longitudinal consent-related abilities of participants in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia study using the MacArthur Competence Assessment Tool-Clinical Research (MacCAT-CR) at protocol-specified times over 18 months. Results Of 1,158 research participants in this analysis, most (n= 650, 56%) had a stable pattern of MacCAT-CR Understanding scores, 235 (20%) improved substantially with no evidence of decline, 273 (24%) had at least one assessment with substantial worsening. During the course of the trial, 43 (4%) fell below the initial threshold for adequate capacity, which was predicted by lower Understanding scores, more severe positive symptoms, and poorer neurocognitive functioning at baseline, and by increases in negative symptoms and deteriorating global status. Conclusions Most participants in this long-term study had stable or improved consent-related abilities, but almost one-fourth experienced substantial worsening and 4% of participants fell below the study’s capacity threshold for enrollment. Clinical investigators should monitor with special care individuals with marginal capacity or higher levels of psychotic symptoms at study entry and those who exhibit clinical worsening during a study. PMID:21561740

  7. Loop-mediated isothermal amplification assay for detection and discrimination of Toxocara canis and Toxocara cati eggs directly from sand samples.

    PubMed

    Macuhova, K; Kumagai, T; Akao, N; Ohta, N

    2010-12-01

    We developed a novel and simple method, using loop-mediated isothermal amplification (LAMP), for the detection and discrimination of Toxocara canis and Toxocara cati eggs. The new method employs 4 steps: (1) concentration of Toxocara eggs in a small amount of sand; (2) dissolution of the proteinaceous membrane of eggs and simultaneously separation of them from the sand using NaClO treatment; (3) extraction of DNA using NaOH treatment; and (4) detection of T. canis / T. cati DNA using a LAMP assay. All these steps are fast, easy to perform, and do not require expensive equipment or reagents. The novel method was tested both experimentally and in a field study. In the laboratory, we could reliably detect as few as 3 T. canis eggs in artificially contaminated sand, if the experiment was repeated twice. In the field trial, we were able to detect T. cati DNA from 4 natural sandpits having moderate to heavy contamination, although not in a single lightly contaminated sandpit. All of the examined sandpits were found to be contaminated with eggs of T. cati, but none appeared to contain T. canis. Our new method could extract DNA from T. canis and T. cati eggs directly from sand samples as well as detect and distinguish these 2 species in a few easy steps, with markedly reduced time and expense.

  8. Efficacy of a new spot-on formulation of selamectin plus sarolaner against Ancylostoma tubaeforme and Toxocara cati in cats.

    PubMed

    Geurden, Thomas; Vatta, Adriano F; Slootmans, Nathalie; King, Vickie L; Lin, Dan; McTier, Tom; Rugg, Douglas

    2017-04-01

    The efficacy of a new spot-on formulation of selamectin plus sarolaner for cats was evaluated against induced infections with Ancylostoma tubaeforme (hookworm) and Toxocara cati (roundworm). Five laboratory studies were conducted using adult, purpose-bred cats. Four of the studies were designed to evaluate efficacy of the combination against A. tubaeforme, the dose-limiting gastrointestinal nematode species for selamectin. In two of these studies non-interference between selamectin and sarolaner was also evaluated. The fifth study evaluated efficacy of the combination against mixed infections of A. tubaeforme and T. cati. The hookworm isolates in three studies were of US origin, as was the roundworm isolate. In the two remaining studies, cats were inoculated with a hookworm isolate of European origin. Cats were inoculated with 150 (±50) to 200 (±50) infective hookworm larvae 30-42days prior to treatment and with 400 infective roundworm eggs 60days prior to treatment. Cats were ranked by pre-treatment faecal egg counts and randomly allocated to different treatment groups. In all studies, cats were treated at the minimum label dose to provide 6.0mg selamectin per kg bodyweight. All animals were euthanized 7-10days after treatment for worm counts. Efficacy was calculated based on the reduction of the geometric mean worm counts in the treated groups versus the placebo-treated control groups. The efficacy against adult hookworms was 99.2%, 94.3% and 100% in three of these studies, and was lower in the remaining two studies. The efficacy against T. cati was 100%. Furthermore, non-interference between sarolaner and selamectin was demonstrated. Thus, a single topical application of the new spot-on formulation of selamectin plus sarolaner at the minimum label dose is effective in the treatment of adult hookworm and roundworm infections in cats. Copyright © 2017 Zoetis Services LLC. Published by Elsevier B.V. All rights reserved.

  9. Prevalence of Toxocara cati and other parasites in cats' faeces collected from the open spaces of public institutions: Buenos Aires, Argentina.

    PubMed

    Sommerfelt, I E; Cardillo, N; López, C; Ribicich, M; Gallo, C; Franco, A

    2006-09-10

    Toxocarosis is a worldwide parasitic infection that affects both cats and dogs. Toxocara cati (Schrank, 1788) syn. Toxocara mystax (Zeder, 1800) prevalence was studied in faeces from stray cats collected from the open spaces of public institutions of Buenos Aires city, both building and surrounding open spaces are fenced off. Of the 465 samples obtained from March to June of 2005, 58.3% were found to have parasite eggs. The following parasites were identified from the 271 positive samples: T. cati (61.2%), Cystoisospora spp. (20.3%), Trichuris spp. (17.0%), Toxascaris leonina (15.1%), Ancylostoma spp. (14%) and Aelurostrongylus abstrusus (2.6%). T. cati prevalence was 35.7% (95% confidence interval: 31.2-40.1), with a 42.2% single isolations. The most frequent combination was T. cati and Cystoisospora spp. (9%). More than half the areas studied showed over 40% prevalence. Seventy-one percent of the collected samples were fresh with a variable moist consistency and 29% were older with a dry consistency. A statistically significant association was found between sample consistency and presence of parasites (chi2 = 10.81; p = 0.001) as also between sample consistency and presence of T. cati (chi2 = 11.27; p = 0.0007). Moist consistencies were significantly different from the rest: consistency (wet or dry) versus parasites (z = 1.95; p = 0.02) (95% confidence interval: 0.004-0.203); consistency (wet or dry) versus T. cati (z = 3.25; p = 0.0006) (95% confidence interval: 0.075-0.254). The cat population that inhabits these public green spaces contaminates the environment, thus transforming them into dangerous spaces with a variable rate for the human population that spends time in these places.

  10. Restrictive symptomatic inclusion criteria create barriers to clinical research in schizophrenia negative symptoms: an analysis of the CATIE dataset.

    PubMed

    Dunayevich, Eduardo; Chen, Chao-Yin; Marder, Stephen R; Rabinowitz, Jonathan

    2014-10-01

    Persistent negative symptoms are an important area of clinical research. However, there is limited consensus on how to define positive and negative symptom severity thresholds for inclusion in clinical trials. From the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset we evaluated the performance of varying baseline negative and positive symptom thresholds on baseline symptom severity, change from baseline, and negative symptom variance attributable to positive symptom change. In CATIE, we first identified the group of subjects lacking an exacerbation prior to study enrollment. Six subsets with varying baseline positive and negative symptom thresholds were then identified. Baseline characteristics were summarized; negative and positive symptom change from baseline through month 3 was calculated both as crude change and change adjusted for corresponding baseline scores. Sensitivity analyses and correlations were calculated to assess the extent to which negative symptom variance was attributable to positive symptom change. More restrictive baseline symptom severity thresholds yielded a considerably smaller sample size and higher negative and lower positive symptoms at baseline. Unadjusted negative symptom change was greater with more restrictive criteria; when adjusted for baseline severity the magnitude of change was comparable across subsets. The amount of variance in negative symptom change attributed to positive symptom change was also comparable across subsets. The use of restrictive positive and negative symptom thresholds yields a marked decrease in eligible sample size with no clear improvement in adjusted negative symptom change or amount of variance associated with positive symptom change. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  11. The Effects of Land use on Soil Properties and Runoff Response at the CATIE Farm, Turrialba, Costa Rica.

    NASA Astrophysics Data System (ADS)

    Toohey, R.; Brooks, E. S.; Jones, J.; Boll, J.

    2006-12-01

    Runoff response in humid tropical areas often is assumed to occur due to infiltration excess. Rainfall intensities in these areas can be monstruous. However, at the Centro Agronómico Tropical de Investigación y Enseñanza (CATIE) farm near Turrialba in Costa Rica, we have observed that volcanically derived soils have very high infiltration capacities, depending on the land use type, suggesting that saturation excess overland flow mechanism are important in explaining the runoff response. In this study we compared field-scale (1-6 ha) runoff response of four different types of prominent land use on the CATIE farm: forest, a coffee agroforestry system, sugar cane, and pasture. The research site is located at approximately 650 masl in deep soils on the tropical wet Caribbean slope of Costa Rica. Hydrograph analysis of observed runoff data suggest that the runoff mechanism in forest, coffee and sugar cane sites depends much more on the amount of soil storage (e.g. saturated-excess overland flow) than in the pasture site. The pasture site exhibits more of an infiltration-excess response. In this presentation we present differences in several soil properties that correlate with land use. We simulated measured runoff responses using the Soil Moisture Routing (SMR) model in this high rainfall, deep soil environment because of its ability to simulate saturation-excess overland flow and lateral flows.

  12. [A comparison of soil contamination with Toxocara canis and Toxocara cati eggs in rural and urban areas of Wielkopolska district in 2000-2005].

    PubMed

    Mizgajska-Wiktor, Hanna; Jarosz, Wojciech

    2007-01-01

    The aim of the studies was to compare the degree of soil contamination with Toxocara canis and T. cati eggs in rural and urban areas depending on time of sampling and type of places examined. Material and methods. Over 2000-2005 a total of 538 soil samples from 3 villages and 368 from Poznań city (Poland) areas were examined for Toxocara spp. eggs. In spring 418 samples in rural areas and 184 samples in urban areas were collected and in autumn 120 and 184 respectively. The samples were examined using flotation technique in saturated sodium nitrate. The discrimination of T. canis and T. cati eggs was based on the size of eggs and transparency of shell layers. Results. The contamination of soil with Toxocara eggs was higher in the urban areas (19.8% positive samples) than in the rural ones (15.6% positive samples) and city or village-backyards were most heavily contaminated. Both, in the villages and in the city, the degree of soil contamination with eggs in spring and autumn was similar (17.6 and 14.8% positive samples respectively). T. cati eggs were much more prevalent in urban areas (97% of all eggs recovered) while T. canis in rural areas (84% of all recovered eggs). The share of T. canis and T. cati eggs in soil contamination did not depend on the time of sampling.

  13. Microarray gene expression analysis reveals major differences between Toxocara canis and Toxocara cati neurotoxocarosis and involvement of T. canis in lipid biosynthetic processes.

    PubMed

    Janecek, Elisabeth; Wilk, Esther; Schughart, Klaus; Geffers, Robert; Strube, Christina

    2015-06-01

    Toxocara canis and Toxocara cati are globally occurring intestinal nematodes of dogs and cats with a high zoonotic potential. Migrating larvae in the CNS of paratenic hosts, including humans, may cause neurotoxocarosis resulting in a variety of neurological symptoms. Toxocara canis exhibits a stronger affinity to the CNS than T. cati, causing more severe neurological symptoms in the mouse model. Pathomechanisms of neurotoxocarosis as well as host responses towards the respective parasite are mostly unknown. Therefore, the aim of this study was to characterise the pathogenesis at a transcriptional level using whole genome microarray expression analysis and identify differences and similarities between T. canis- and T. cati-infected brains. Microarray analysis was conducted in cerebra and cerebella of infected C57Bl/6J mice 42daysp.i. revealing more differentially transcribed genes for T. canis- than T. cati-infected brains. In cerebra and cerebella of T. canis-infected mice, a total of 2304 and 1954 differentially transcribed genes, respectively, were identified whereas 113 and 760 differentially transcribed genes were determined in cerebra and cerebella of T. cati-infected mice. Functional annotation analysis revealed major differences in host responses in terms of significantly enriched biological modules. Up-regulated genes were mainly associated with the terms "immune and defence response", "sensory perception" as well as "behaviour/taxis" retrieved from the Gene Ontology database. These observations indicate a strong immune response in both infection groups with T. cati-infected brains revealing less severe reactions. Down-regulated genes in T. canis-infected cerebra and cerebella revealed a significant enrichment for the Gene Ontology term "lipid/cholesterol biosynthetic process". Cholesterol is a highly abundant and important component in the brain, representing several functions. Disturbances of synthesis as well as concentration changes may lead to

  14. Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse.

    PubMed

    Janecek, Elisabeth; Beineke, Andreas; Schnieder, Thomas; Strube, Christina

    2014-04-22

    Infective larvae of the worldwide occurring zoonotic roundworm T. canis exhibit a marked affinity to the nervous tissues of paratenic hosts. In humans, most cases of neurotoxocarosis are considered to be caused by larvae of T. canis as T. cati larvae have rarely been found in the CNS in previous studies. However, direct comparison of studies is difficult as larval migration depends on a variety of factors including mouse strains and inoculation doses. Therefore, the present study aims to provide a direct comparison of both roundworm species in mice as a model for paratenic hosts with specific focus on the CNS during the acute and chronic phase of disease to provide a basis for further studies dealing with neurotoxocarosis. C57Bl/6J mice were infected with 2000 embryonated T. canis and T. cati eggs, respectively as well as Balb/c mice infected with T. cati eggs only. On 8 time points post infection, organs were removed and microscopically examined for respective larvae. Special focus was put on the CNS, including analysis of larval distribution in the cerebrum and cerebellum, right and left hemisphere as well as eyes and spinal cord. Additionally, brains of all infection groups as well as uninfected controls were examined histopathologically to characterize neurostructural damage. Significant differences in larval distribution were observed between and within the infection groups during the course of infection. As expected, significantly higher recovery rates of T. canis than T. cati larvae were determined in the brain. Surprisingly, significantly more T. canis larvae could be found in cerebra of infected mice whereas T. cati larvae were mainly located in the cerebellum. Structural damage in brain tissue could be observed in all infection groups, being more severe in brains of T. canis infected mice. The data obtained provides an extensive characterization of migrational routes of T. canis and T. cati in the paratenic host mouse in direct comparison. Even though to

  15. Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse

    PubMed Central

    2014-01-01

    Background Infective larvae of the worldwide occurring zoonotic roundworm T. canis exhibit a marked affinity to the nervous tissues of paratenic hosts. In humans, most cases of neurotoxocarosis are considered to be caused by larvae of T. canis as T. cati larvae have rarely been found in the CNS in previous studies. However, direct comparison of studies is difficult as larval migration depends on a variety of factors including mouse strains and inoculation doses. Therefore, the present study aims to provide a direct comparison of both roundworm species in mice as a model for paratenic hosts with specific focus on the CNS during the acute and chronic phase of disease to provide a basis for further studies dealing with neurotoxocarosis. Methods C57Bl/6J mice were infected with 2000 embryonated T. canis and T. cati eggs, respectively as well as Balb/c mice infected with T. cati eggs only. On 8 time points post infection, organs were removed and microscopically examined for respective larvae. Special focus was put on the CNS, including analysis of larval distribution in the cerebrum and cerebellum, right and left hemisphere as well as eyes and spinal cord. Additionally, brains of all infection groups as well as uninfected controls were examined histopathologically to characterize neurostructural damage. Results Significant differences in larval distribution were observed between and within the infection groups during the course of infection. As expected, significantly higher recovery rates of T. canis than T. cati larvae were determined in the brain. Surprisingly, significantly more T. canis larvae could be found in cerebra of infected mice whereas T. cati larvae were mainly located in the cerebellum. Structural damage in brain tissue could be observed in all infection groups, being more severe in brains of T. canis infected mice. Conclusions The data obtained provides an extensive characterization of migrational routes of T. canis and T. cati in the paratenic host

  16. Treatment of naturally Notoedres cati-infested cats with a combination of imidacloprid 10 % / moxidectin 1 % Spot-on (Advocate® / Advantage® Multi, Bayer).

    PubMed

    Hellmann, Klaus; Petry, Gabriele; Capari, Balazs; Cvejic, Dejan; Krämer, Friederike

    2013-08-01

    Notoedric mange (feline scabies) is a rare, but highly contagious disease of cats and kittens caused by Notoedres cati (N. cati), which can infest other animals and also humans. The study objective was to determine the efficacy and safety of 10 % imidacloprid/ 1 % moxidectin (Advocate®/Advantage® Multi spot-on for cats) against natural N. cati infestation in cats. Sixteen cats were randomly assigned to treatment group or negative control using pre-treatment mite counts. The treatment group received a single spot on treatment of the investigational veterinary product (IVP) according to label instructions. The control group stayed untreated. Five cats from the negative control were treated with the IVP at the end of the study and observed for 28 days to increase the treatment group. Skin scrapings and mite counts were performed 28 days post treatment (p.t.). Notoedric skin lesion assessments with clinical scoring were performed regularly. Five animals had to be removed prematurely from the study population due to different reasons. The number of viable N. cati mites in all treated animals 28 days p.t. was zero compared with 2.8 ± 3.0 in the negative control, being significantly lower for treated cats (p = 0.0019, Wilcoxon test). The resulting efficacy was 100 %. Clinical cure based on skin lesion assessment was achieved 28 days p.t. in 100 % of all treated animals completing 28 study days. The IVP was well tolerated and applied at the minimal therapeutic dose (10 mg imidacloprid/1 mg moxidectin/kg body weight) a high therapeutic efficacy in curing N. cati infestations and feline scabies clinical symptoms was recorded.

  17. Treatment of third-stage larvae of Toxocara cati with milbemycin oxime plus praziquantel tablets and emodepside plus praziquantel spot-on formulation in experimentally infected cats.

    PubMed

    Wolken, Sonja; Böhm, Claudia; Schaper, Roland; Schnieder, Thomas

    2012-11-01

    Toxocara cati is the most prevalent gastrointestinal helminth in cats worldwide, with cats of all ages at risk of infection. An anthelminthic treatment that not only affects the gut-dwelling stages of this parasite but is also effective against developmental stages in the tissue has the advantage that the pathology caused by migrating larvae is minimized and the need for repeated treatments is reduced. This study was conducted to evaluate the efficacy of milbemycin oxime/praziquantel tablets (Milbemax®, Novartis) against third-stage larvae of T. cati in comparison to a spot-on formulation of emodepside and praziquantel (Profender®, Bayer). Twenty-four kittens were experimentally infected with T. cati and randomly allocated to three study groups. Treatments were performed at the minimum therapeutic dosage 5 days after the experimental infection. The development of patent infections was monitored and all cats were dewormed 50 days post-infection. Efficacies were calculated based on counts of excreted worms in the treated groups compared to a negative control group. Seven of the eight cats in the negative control group developed a patent T. cati infection and all cats were excreting worms at the end of the study (geometric mean worm count 18.1). No efficacy could be observed for the milbemycin oxime-treated animals. All cats developed a patent infection and excreted worms (geometric mean worm count 27.7). The treatment with Profender® was 98.5 % effective against L3 of T. cati. One cat developed a patent infection and was excreting worms at the end of the study (geometric mean worm count 0.3). No adverse reactions were noted in either treatment group.

  18. Loparite, a rare-earth ore (Ce, Na, Sr, Ca)(Ti, Nb, Ta, Fe+3)O3

    USGS Publications Warehouse

    Hedrick, J.B.; Sinha, S.P.; Kosynkin, V.D.

    1997-01-01

    The mineral loparite (Ce, NA, Sr, Ca)(Ti, Nb, Ta, Fe+3)O3 is the principal ore of the light-group rare-earth elements (LREE) in Russia. The complex oxide has a perovskite (ABO3) structure with coupled substitutions, polymorphism, defect chemistry and a tendency to become metamict. The A site generally contains weakly bonded, easily exchanged cations of the LREE, Na and Ca. The B site generally contains smaller, highly charged cations of Ti, Nb or Fe+3. Mine production is from Russia's Kola Peninsula. Ore is beneficiated to produce a 95% loparite concentrate containing 30% rare-earth oxides. Loparite concentrate is refined by either a chlorination process or acid decomposition process to recover rare-earths, titanium, niobium and tantalum. Rare-earths are separated by solvent extraction and selective precipitation/dissolution. The concentrate is processed at plants in Russia, Estonia and Kazakstan.

  19. Loparite, a rare-earth ore (Ce, Na, Sr, Ca)(Ti, Nb, Ta, Fe+3)O3

    USGS Publications Warehouse

    Hedrick, James B.; Sinha, Shyama P.; Kosynkin, Valery D.

    1997-01-01

    The mineral loparite (Ce, NA, Sr, Ca)(Ti, Nb, Ta, Fe+3)O3 is the principal ore of the light-group rare-earth elements (LREE) in Russia. The complex oxide has a perovskite (ABO3) structure with coupled substitutions, polymorphism, defect chemistry and a tendency to become metamict. The A site generally contains weakly bonded, easily exchanged cations of the LREE, Na and Ca. The B site generally contains smaller, highly charged cations of Ti, Nb or Fe+3. Mine production is from Russia's Kola Peninsula. Ore is beneficiated to produce a 95% loparite concentrate containing 30% rare-earth oxides. Loparite concentrate is refined by either a chlorination process or acid decomposition process to recover rare-earths, titanium, niobium and tantalum. Rare-earths are separated by solvent extraction and selective precipitation/dissolution. The concentrate is processed at plants in Russia, Estonia and Kazakstan.

  20. Serological evidence of exposure to Herpes Simplex Virus type 1 is associated with cognitive deficits in the CATIE schizophrenia sample.

    PubMed

    Yolken, Robert H; Torrey, E Fuller; Lieberman, Jeffrey A; Yang, Shuojia; Dickerson, Faith B

    2011-05-01

    Cognitive impairment is a core feature of schizophrenia. Previous studies have indicated that exposure to neurotropic infectious agents such as Herpes Simplex Virus type 1 may contribute to cognitive deficits and neuroanatomical abnormalities in individuals with schizophrenia. We examined the association between exposure to neurotropic infectious agents and cognitive function in 1308 participants in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial. This sample included all of the individuals in the CATIE trial for whom baseline blood samples were available. Cognition was evaluated at baseline by a test battery which yielded composite scores in the domains of processing speed, verbal memory, vigilance, reasoning, and working memory as well as a summary neurocognitive score. Solid phase immunoassay techniques were used to measure IgG class antibodies to Herpes Simplex Virus type 1 (HSV-1), Herpes Simplex Virus type 2 (HSV-2), Cytomegalovirus (CMV), and to Toxoplasma gondii (T gondii) in the sera of the study individuals. We found a significant association between the neurocognitive summary score and antibodies to HSV-1 but not to HSV-2, CMV, or T. gondii. There was also a significant association between HSV-1 exposure and the Verbal Memory, Vigilance, and Processing Speed composite scores. HSV-1 may modulate the neurocognitive function of individuals with schizophrenia through its ability to establish latency in the central nervous system and undergo periodic reactivation. A better understanding of the role of HSV-1 may lead to better methods of treatment for the cognitive impairments associated with schizophrenia. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. Prevention of Lactogenic Toxocara cati Infections in Kittens by Application of an Emodepside/Praziquantel Spot-on (Profender®) to the Pregnant Queen.

    PubMed

    Böhm, Claudia; Petry, Gabriele; Schaper, Roland; Wolken, Sonja; Strube, Christina

    2015-08-01

    This study aimed to evaluate the efficacy of an emodepside 2.1 % (w/v)/praziquantel 8.6 % (w/v) topical solution (Profender® spot-on for cats) in the prevention of lactogenic Toxocara cati infections. A controlled test was performed with two groups of 8 cats with confirmed pregnancy. All cats were infected with daily doses of 2000 T. cati eggs for 10 consecutive days starting 50 days post conception to produce an acute infection. Treatment was performed 60 days post conception. Queens in the treatment group received the emodepside/praziquantel solution at the minimum therapeutic dose (3 mg/kg emodepside and 12 mg/kg praziquantel), while the control group was treated with a placebo spot-on. Efficacy was evaluated 56 days post partum by necropsy of one randomly selected kitten of each litter and comparison of the worm burdens between the study groups. Additionally the necropsy results were supported by quantification of worms expelled with the faeces after deworming of the remaining kittens and all queens. The treatment in late pregnancy resulted in an efficacy of 98.7 % (p < 0.0001). All necropsied control kittens were infected (geometric mean 30.6). Seven of 8 kittens from treated mothers were free of T. cati (geometric mean 0.4). Worm counts after deworming reflected the results obtained at necropsy. No side effects of the treatment were observed. It is concluded that treatment with an emodepside/praziquantel spot-on solution during late pregnancy effectively prevents lactogenic transmission of T. cati to the offspring. The study design facilitated the generation of reliable data, while at the same time a minimum number of animals was sacrificed.

  2. Distribution and dynamics of soil contamination with Toxocara canis and Toxocara cati eggs in Poland and prevention measures proposed after 20 years of study.

    PubMed

    Mizgajska-Wiktor, Hanna; Jarosz, Wojciech; Fogt-Wyrwas, Renata; Drzewiecka, Agnieszka

    2017-01-30

    The studies conducted in the years 1994-2013 allowed to determine the distribution of Toxocara spp. eggs in the soil of different types of urban and rural areas in Poland and to establish seasonal and multi-year dynamics of soil contamination with T. cati and T. canis eggs. Out of 3309 soil samples examined, 14.9% contained the eggs and the average density was 3.43 eggs/100g of soil. The level of soil contamination was the highest in cities, lower in villages, and lowest in small towns. In urban areas eggs of T. cati were found more frequently than of T. canis, while in rural areas the opposite was true. Both, in urban and rural areas, the sites most heavily contaminated with Toxocara spp. eggs were household surroundings (backyards). Recreation areas (parks, playgrounds, lake beaches) were significantly less contaminated. In older parts of Poznań, in backyards, soil contamination with the eggs was generally high each month, being lowest in July and highest in December and the prevalence of T. cati eggs was much higher than of T. canis. The prevention policy introduced in the city thus far - paying great attention to dog faeces but not to cats was unsatisfactory. After 18 years of such policy, the number of Toxocara spp. eggs dropped significantly but it was not a linear phenomenon - the intensity of soil contamination fluctuated. To be more effective, preventive measures should be preceded with discrimination of T. canis and T. cati eggs recovered in the soil and for this purpose the new molecular techniques should be applied. A survey conducted in the population in 2010 showed that people's awareness on the significance of pets in the transmission of dangerous zoonoses to humans was unsatisfactory. We recommend to expand the knowledge of the subject among the populace.

  3. Development and validation of a fecal PCR assay for Notoedres cati and application to notoedric mange cases in bobcats (Lynx rufus) in Northern California, USA.

    PubMed

    Stephenson, Nicole; Clifford, Deana; Worth, S Joy; Serieys, Laurel E K; Foley, Janet

    2013-04-01

    Notoedric mange in felids is a devastating disease caused by a hypersensitivity reaction to the mite Notoedres cati. The burrowing of the mite causes intense pruritis resulting in self-mutilation, secondary bacterial infection, and often death of affected felids if left untreated. Our understanding of how notoedric mange is maintained in felid populations, and the true geographic extent of infestations, has been hampered because wild felids are elusive and, thus, traditional diagnostic methods are difficult to implement. To create a noninvasive diagnostic test, we developed and validated a novel PCR assay to detect N. cati DNA in fecal samples of bobcats (Lynx rufus) and used this assay to investigate a recent outbreak of mange in northern California, United States. Although the fecal PCR assay was 100% specific and could detect as few as 1.9 mites/200 μg of feces, it had a moderate sensitivity of 52.6%, potentially due to intermittent shedding of mites in feces or fecal PCR inhibitors. In a field investigation, 12% (95% confidence interval [CI]: 0.06, 0.23) of fecal samples (n=65) collected from Rancho San Antonia County Park and Open Space Preserve in Santa Clara County, California were PCR-positive for N. cati. When this estimate was adjusted for test sensitivity, the corrected proportion for fecal samples containing N. cati was 23% (95% CI: 0.14, 0.36), suggesting widespread mange in this area. This novel PCR assay will be an important tool to assess the distribution and spread of notoedric mange in bobcats and could be validated to test other wild felids such as mountain lions (Puma concolor). The assay could also be used to detect notoedric mange in domestic cats (Felis catus), particularly feral cats, which may also suffer from mange and could represent an important contributor to mange in periurban bobcat populations.

  4. Toxocara eggs shed by dogs and cats and their molecular and morphometric species-specific identification: is the finding of T. cati eggs shed by dogs of epidemiological relevance?

    PubMed

    Fahrion, A S; Schnyder, M; Wichert, B; Deplazes, P

    2011-04-19

    Intestinal infections with Toxocara cati and Toxocara canis in their definitive host (felids and canids, respectively) are diagnosed by egg identification in faeces using coproscopical techniques. The Toxocara species is assumed to comply with the species from which the examined faeces were obtained, i.e. T. cati in cats and T. canis in dogs. We isolated and measured Toxocara eggs from faecal samples of 36 cats and 35 dogs from Switzerland and identified the Toxocara species by PCR. Amongst the isolates originating from dogs, 24 (68.5%) were determined as T. canis and 11 (31.5%) as T. cati. In all samples originating from cats, only T. cati was identified. Based on PCR identification, eggs of T. canis (n=241) and T. cati (n=442) were measured, revealing statistically significant different (p<0.001) mean sizes of 62.3 by 72.7 μm for T. cati and 74.8 by 86.0 μm for T. canis eggs. Considering that coprophagy is not unusual for dogs, a considerable percentage of Toxocara infections coproscopically diagnosed in dogs, as well as assumptions on anthelminthic resistance in regularly treated dogs, might in fact relate to intestinal passages of eggs following the uptake of other animals' faeces.

  5. Seroprevalences of antibodies against Bartonella henselae and Toxoplasma gondii and fecal shedding of Cryptosporidium spp, Giardia spp, and Toxocara cati in feral and pet domestic cats.

    PubMed

    Nutter, Felicia B; Dubey, J P; Levine, Jay F; Breitschwerdt, Edward B; Ford, Richard B; Stoskopf, Michael K

    2004-11-01

    To compare seroprevalences of antibodies against Bartonella henselae and Toxoplasma gondii and fecal shedding of Cryptosporidium spp, Giardia spp, and Toxocara cati in feral and pet domestic cats. Prospective cross-sectional serologic and coprologic survey. 100 feral cats and 76 pet domestic cats from Randolph County, NC. Blood and fecal samples were collected and tested. Percentages of feral cats seropositive for antibodies against B. henselae and T. gondii (93% and 63%, respectively) were significantly higher than percentages of pet cats (75% and 34%). Percentages of feral and pet cats with Cryptosporidium spp (7% of feral cats; 6% of pet cats), Giardia spp (6% of feral cats; 5% of pet cats), and T. cati ova (21% of feral cats; 18% of pet cats) in their feces were not significantly different between populations. Results of CBCs and serum biochemical analyses were not significantly different between feral and pet cats, except that feral cats had a significantly lower median PCV and significantly higher median neutrophil count. Results suggested that feral and pet cats had similar baseline health status, as reflected by results of hematologic and serum biochemical testing and similar prevalences of infection with Cryptosporidium spp, Giardia spp, and T. cati. Feral cats did have higher seroprevalences of antibodies against B. henselae and T. gondii than did pet cats, but this likely was related to greater exposure to vectors of these organisms.

  6. The relationship between suicide and violence in schizophrenia: Analysis of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset

    PubMed Central

    Witt, Katrina; Hawton, Keith; Fazel, Seena

    2014-01-01

    Background Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. Aims The aim of this study is to investigate whether suicidal behaviors, including suicidal ideation, threats, and attempts, are significantly associated with increased violence risk in individuals with schizophrenia. Method Data for these analyses were obtained from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial, a randomized controlled trial of antipsychotic medication in 1460 adults with schizophrenia. Univariate Cox regression analyses were used to calculate hazard ratios (HRs) for suicidal ideation, threats, and attempts. Multivariate analyses were conducted to adjust for common confounding factors, including: age, alcohol or drug misuse, major depression, antisocial personality disorder, depression, hostility, positive symptom, and poor impulse control scores. Tests of discrimination, calibration, and reclassification assessed the incremental predictive validity of suicidal behaviors for the prediction of violence risk. Results Suicidal threats and attempts were significantly associated with violence in both males and females with schizophrenia with little change following adjustment for common confounders. Only suicidal threats, however, were associated with a significant increase in incremental validity beyond age, diagnosis with a comorbid substance use disorder, and recent violent behavior. Conclusions Suicidal threats are independently associated with violence risk in both males and females with schizophrenia, and may improve violence risk prediction. PMID:24581550

  7. The relationship between suicide and violence in schizophrenia: analysis of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset.

    PubMed

    Witt, Katrina; Hawton, Keith; Fazel, Seena

    2014-04-01

    Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. The aim of this study is to investigate whether suicidal behaviors, including suicidal ideation, threats, and attempts, are significantly associated with increased violence risk in individuals with schizophrenia. Data for these analyses were obtained from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial, a randomized controlled trial of antipsychotic medication in 1460 adults with schizophrenia. Univariate Cox regression analyses were used to calculate hazard ratios (HRs) for suicidal ideation, threats, and attempts. Multivariate analyses were conducted to adjust for common confounding factors, including: age, alcohol or drug misuse, major depression, antisocial personality disorder, depression, hostility, positive symptom, and poor impulse control scores. Tests of discrimination, calibration, and reclassification assessed the incremental predictive validity of suicidal behaviors for the prediction of violence risk. Suicidal threats and attempts were significantly associated with violence in both males and females with schizophrenia with little change following adjustment for common confounders. Only suicidal threats, however, were associated with a significant increase in incremental validity beyond age, diagnosis with a comorbid substance use disorder, and recent violent behavior. Suicidal threats are independently associated with violence risk in both males and females with schizophrenia, and may improve violence risk prediction. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  8. Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia

    PubMed Central

    HILL, S. KRISTIAN; SWEENEY, JOHN A.; HAMER, ROBERT M.; KEEFE, RICHARD S.E.; PERKINS, DIANA O.; GU, HONGBIN; MCEVOY, JOSEPH P.; LIEBERMAN, JEFFREY A.

    2011-01-01

    Efficient and reliable assessments of cognitive treatment effects are essential for the comparative evaluation of procognitive effects of pharmacologic therapies. Yet, no studies have addressed the sensitivity and efficiency with which neurocognitive batteries evaluate cognitive abilities before and after treatment. Participants were primarily first episode schizophrenia patients who completed baseline (n = 367) and 12-week (n = 219) assessments with the BACS (Brief Assessment of Cognition in Schizophrenia) and CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) neuropsychological batteries in a clinical trial comparing olanzapine, quetiapine, and risperidone. Exploratory factor analysis revealed that performance on both batteries was characterized by a single factor of generalized cognitive deficit for both baseline performance and cognitive change after treatment. Both batteries estimated similar levels of change following treatment, although the BACS battery required half the administration time. Because a unitary factor characterized baseline cognitive abilities in early psychosis as well as cognitive change after treatment with atypical antipsychotic medications, short batteries such as the BACS may efficiently provide sufficient assessment of procognitive treatment effects with antipsychotic medications. Assessment of cognitive effects of adjunctive therapies targeting specific cognitive domains or impairments may require more extensive testing of the domains targeted to maximize sensitivity for detecting specific predicted cognitive outcomes. PMID:18282319

  9. Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia.

    PubMed

    Hill, S Kristian; Sweeney, John A; Hamer, Robert M; Keefe, Richard S E; Perkins, Diana O; Gu, Hongbin; McEvoy, Joseph P; Lieberman, Jeffrey A

    2008-03-01

    Efficient and reliable assessments of cognitive treatment effects are essential for the comparative evaluation of procognitive effects of pharmacologic therapies. Yet, no studies have addressed the sensitivity and efficiency with which neurocognitive batteries evaluate cognitive abilities before and after treatment. Participants were primarily first episode schizophrenia patients who completed baseline (n = 367) and 12-week (n = 219) assessments with the BACS (Brief Assessment of Cognition in Schizophrenia) and CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) neuropsychological batteries in a clinical trial comparing olanzapine, quetiapine, and risperidone. Exploratory factor analysis revealed that performance on both batteries was characterized by a single factor of generalized cognitive deficit for both baseline performance and cognitive change after treatment. Both batteries estimated similar levels of change following treatment, although the BACS battery required half the administration time. Because a unitary factor characterized baseline cognitive abilities in early psychosis as well as cognitive change after treatment with atypical antipsychotic medications, short batteries such as the BACS may efficiently provide sufficient assessment of procognitive treatment effects with antipsychotic medications. Assessment of cognitive effects of adjunctive therapies targeting specific cognitive domains or impairments may require more extensive testing of the domains targeted to maximize sensitivity for detecting specific predicted cognitive outcomes.

  10. Evaluation of “Subject Advocate” Procedures in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Study

    PubMed Central

    Stroup, T Scott; Appelbaum, Paul S

    2006-01-01

    Because the decision-making capacity of individuals with schizophrenia may fluctuate, additional protections for such persons who enroll in long-term research studies may be needed. For the NIMH-sponsored Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia study, new procedures were developed to help ensure an objective assessment of a patient's continued participation in the study if decision-making capacity lapsed. Each research participant had a subject advocate who could recommend that the subject be withdrawn from the study if capacity lapsed and continued participation was not in the subject's best interest. The main goals of the procedures were to protect the interests of subjects and to prevent unnecessary dropouts. We surveyed research personnel regarding the effectiveness and implementation of the procedures. Responses were received from 73 personnel at 49 research sites, representing 70% of possible respondents and 91% of eligible sites. A majority of respondents were favorably disposed toward subject advocates, and though most reported that the procedures had no discernible effect on study recruitment, subject autonomy, or subject retention, for those who reported an impact, it was almost always positive. Some respondents reported that the procedures helped by engaging family members and promoting a positive view of schizophrenia research. A majority thought that similar arrangements would be useful in future longitudinal research studies. Nonspecific benefits included good public relations and engagement of family members. Improved training regarding the procedures may be needed to achieve specific goals of enhanced patient autonomy and retention in the study. PMID:16282635

  11. Effect of antipsychotic medication on overall life satisfaction among individuals with chronic schizophrenia: findings from the NIMH CATIE study.

    PubMed

    Fervaha, Gagan; Agid, Ofer; Takeuchi, Hiroyoshi; Foussias, George; Remington, Gary

    2014-07-01

    The field of schizophrenia is redefining optimal outcome, moving beyond clinical remission to a more comprehensive model including functional recovery and improved subjective well-being. Although numerous studies have evaluated subjective outcomes within the domain of subjective quality of life in patients with schizophrenia, less is known about global evaluations of subjective well-being. This study examined the effects of antipsychotic medication on overall life satisfaction in patients with chronic schizophrenia. Data were drawn from the Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE) study, where participants with a DSM-IV diagnosis of schizophrenia were randomized to receive olanzapine, perphenazine, quetiapine, risperidone or ziprasidone under double-blind conditions (N=753). The primary outcome measure was prospective change in subjectively evaluated overall life satisfaction scores following 12 months of antipsychotic treatment. Psychopathology, medication side effects and functional status were also evaluated, among other variables. Patients experienced modest improvements in overall life satisfaction (d=0.22, p<0.001), with no differences between antipsychotic medications (all tests, p>0.05). Change in severity of positive, negative, and depressive symptoms as well as functional status each demonstrated a small, albeit statistically significant, association with change in life satisfaction (r=0.10-0.21, p׳s<0.01). In a multivariate regression model, change in clinical symptoms and functional status had limited independent predictive value for change in life satisfaction scores (explained variance <3%). These data suggest that despite antipsychotic medications being effective for symptom-based psychopathology, such clinical effectiveness does not necessarily translate to improved general satisfaction with life. Clinicians should be aware that these two domains are not inextricably linked. Copyright © 2014 Elsevier B.V. and ECNP. All

  12. Characterization of soluble acyl-ACP desaturases from Camelina sativa, Macadamia tetraphylla and Dolichandra unguis-cati.

    PubMed

    Rodríguez, Manuel Fernando Rodríguez; Sánchez-García, Alicia; Salas, Joaquín J; Garcés, Rafael; Martínez-Force, Enrique

    2015-04-15

    Acyl-acyl carrier protein (ACP) desaturases (EC 1.14.19.2) are soluble enzymes that catalyse the insertion of a double bond into saturated fatty acid bound in saturated acyl chains bound to ACP in higher plants, producing cis-monounsaturated fatty acids. Three types of soluble acyl-ACP desaturases have been described: Δ(9)-acyl-ACP, Δ(6)-acyl-ACP and Δ(4)-acyl-ACP desaturases, which differ in the substrate specificity and the position in which the double bond is introduced. In the present work, Camelina sativa (CsSAD), Macadamia tetraphylla (MtSAD) and Dolichandra unguis-cati (DuSAD) desaturases were cloned, sequenced and characterized. Single copies of CsSAD, MtSAD and DuSAD with three, one and two different alleles, respectively, were found. The corresponding mature proteins were heterologously expressed in Escherichia coli for biochemical characterization in protein extracts. The recombinant CsSAD enzyme showed 300-fold higher specificity towards 18:0-ACP than 16:0-ACP. Similar profile exhibited MtSAD although the differences in the specificity were lower, around 170-fold higher for 18:0-ACP than 16:0-ACP. Furthermore, DuSAD presented a profile showing preference towards 16:0-ACP against 18:0-ACP, around twice more, being so a Δ(9) palmitoyl-ACP desaturase. Also, we reported the expression profile of CsSAD, which showed the highest levels of expression in expanding tissues that typically are very active in lipid biosynthesis such as developing seed endosperm. Moreover, the possibility to express a new desaturase in C. sativa (oilseed crop that store high levels of oil and is easy to transform) to create a new line rich in short monounsaturated fatty acid is discussed. Copyright © 2015 Elsevier GmbH. All rights reserved.

  13. Efficacy of a milbemycin oxime-praziquantel combination product against adult and immature stages of Toxocara cati in cats and kittens after induced infection.

    PubMed

    Schenker, R; Bowman, D; Epe, C; Cody, R; Seewald, W; Strehlau, G; Junquera, P

    2007-04-10

    Two studies were performed to examine the efficacy of milbemycin oxime against fourth-stage larvae or adults of Toxocara cati. In the study to determine efficacy against fourth-stage larvae, 20 domestic shorthair cats were inoculated with 500 embryonated eggs. Four weeks after inoculation, the animals were allocated to two groups, and cats in one group were treated with medicated tablets containing 4 mg milbemycin oxime and 10mg praziquantel (MILBEMAX) and cats in the other group with placebo tablets. Seven days after treatment the animals were euthanatized and necropsied for worm counting. The number of worms found was significantly (p=0.0002) lower in cats treated with medicated tablets than in cats treated with placebo tablets. The reduction in the number of worms was 96.53%. In the study to determine efficacy against mature adult worms, 13 kittens were inoculated with T. cati embryonated eggs. On day 45 after inoculation and after the infection had been confirmed through faecal examinations for 11 out of the 13 animals, the 11 infected animals were allocated to two groups and treated as in the first study. Seven days after treatment, all animals were euthanatized and necropsied for worm counting. The number of worms found was significantly (p=0.0043) lower in kittens treated with medicated tablets than in kittens treated with placebo tablets. The reduction in the number of worms was 95.90%. No adverse effects were recorded during either study. It is concluded that the milbemycin oxime-praziquantel tablets that were used are efficacious for the control of T. cati infections in cats.

  14. Efficacy of Procox® oral suspension for dogs (0.1% emodepside and 2% toltrazuril) against experimental nematode (Toxocara cati and Ancylostoma tubaeforme) infections in cats.

    PubMed

    Petry, Gabriele; Kruedewagen, Eva; Bach, Thomas; Gasda, Nadine; Krieger, Klemens J

    2011-08-01

    Two exploratory studies were performed to determine the optimum therapeutic dose of Procox(®) for the removal of experimental infection with mature adult Toxocara (T.) cati and Ancylostoma (A.) tubaeforme in kittens. Procox(®) is a new oral suspension containing a combination of the nematocidal and coccidiocidal active principles emodepside (0.1 %) and toltrazuril (2 %).In the first study, 18 eight-weeks-old kittens were inoculated with 450 L3 larvae of T. cati. 56 days after infection, the kittens were allocated to three treatment groups and were treated with 0.5 mg emodepside/kg body weight (group 1), 0.25 mg emodepside/kg body weight (group 2) and 0.1 mg emodepside/kg body weight (group 3), respectively. In the second study, 10 eight-weeks-old kittens were inoculated with 350 L3 larvae of A. tubaeforme. Four weeks after infection, the kittens were allocated to two treatment groups and were treated with 0.1 mg emodepside/kg body weight (group 1) or 0.25 mg emodepside/kg body weight (group 2). In both studies, all kittens received a reference treatment with Drontal(®) (230 mg pyrantel embonate and 20 mg praziquantel per tablet) at the recommended dose of one tablet/4 kg body weight 5 days after treatment with Procox(®). Anthelmintic efficacy was calculated by reduction in worm numbers expelled with the faeces following treatment with Procox(®) as compared with faecal worm numbers after reference treatment with Drontal(®), by thus avoiding necropsy of the animals.In the T. cati study, emodepside was at 99.9 %, 100 % and 96.5 % effective at a dosage of 0.5 mg, 0.25 mg and 0.1 mg per kg body weight, respectively. Against A. tubaeforme emodepside was at 95.7 % and 100 % effective at a dosage of 0.1 mg and 0.25 mg per kg body weight. No adverse events were seen during either study.It can be concluded that Procox(®) is efficacious for the control of mature adult T. cati and A. tubaeforme infections in cats at a single-dose rate of 0.25 mg emodepside/kg body

  15. caTIES: a grid based system for coding and retrieval of surgical pathology reports and tissue specimens in support of translational research.

    PubMed

    Crowley, Rebecca S; Castine, Melissa; Mitchell, Kevin; Chavan, Girish; McSherry, Tara; Feldman, Michael

    2010-01-01

    The authors report on the development of the Cancer Tissue Information Extraction System (caTIES)--an application that supports collaborative tissue banking and text mining by leveraging existing natural language processing methods and algorithms, grid communication and security frameworks, and query visualization methods. The system fills an important need for text-derived clinical data in translational research such as tissue-banking and clinical trials. The design of caTIES addresses three critical issues for informatics support of translational research: (1) federation of research data sources derived from clinical systems; (2) expressive graphical interfaces for concept-based text mining; and (3) regulatory and security model for supporting multi-center collaborative research. Implementation of the system at several Cancer Centers across the country is creating a potential network of caTIES repositories that could provide millions of de-identified clinical reports to users. The system provides an end-to-end application of medical natural language processing to support multi-institutional translational research programs.

  16. Intraspecific variation between the ITS sequences of Toxocara canis, Toxocara cati and Toxascaris leonina from different host species in south-western Poland.

    PubMed

    Fogt-Wyrwas, R; Mizgajska-Wiktor, H; Pacoń, J; Jarosz, W

    2013-12-01

    Some parasitic nematodes can inhabit different definitive hosts, which raises the question of the intraspecific variability of the nematode genotype affecting their preferences to choose particular species as hosts. Additionally, the issue of a possible intraspecific DNA microheterogeneity in specimens from different parts of the world seems to be interesting, especially from the evolutionary point of view. The problem was analysed in three related species - Toxocara canis, Toxocara cati and Toxascaris leonina - specimens originating from Central Europe (Poland). Using specific primers for species identification, internal transcribed spacer (ITS)-1 and ITS-2 regions were amplified and then sequenced. The sequences obtained were compared with sequences previously described for specimens originating from other geographical locations. No differences in nucleotide sequences were established in T. canis isolated from two different hosts (dogs and foxes). A comparison of ITS sequences of T. canis from Poland with sequences deposited in GenBank showed that the scope of intraspecific variability of the species did not exceed 0.4%, while in T. cati the differences did not exceed 2%. Significant differences were found in T. leonina, where ITS-1 differed by 3% and ITS-2 by as much as 7.4% in specimens collected from foxes in Poland and dogs in Australia. Such scope of differences in the nucleotide sequence seems to exceed the intraspecific variation of the species.

  17. Hostility in schizophrenia: An integrated analysis of the combined Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and the European First Episode Schizophrenia Trial (EUFEST) studies

    PubMed Central

    Volavka, J.; Van Dorn, R.A.; Citrome, L.; Kahn, R.S.; Fleischhacker, W.W.; Czobor, P.

    2016-01-01

    Phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study enrolled a sample of 1493 chronic schizophrenia patients. The European First Episode Schizophrenia Trial (EUFEST) enrolled 498 patients. We have combined these two samples to study the effects of hostility on study discontinuation as well as to examine correlates and predictors of hostility. Individual data from 1154 patients with complete data were used for analyses. Survival analysis demonstrated that higher hostility was associated with earlier all-cause treatment discontinuation. Furthermore, regression analysis indicated that increased hostility was associated with more severe positive symptoms, lower adherence to pharmacological treatment, younger age, impaired insight, and more drug or alcohol consumption. The clinical implications of the results point to the importance of establishing therapeutic alliance while managing patient’s symptoms of hostility with antipsychotics such as olanzapine combined with psychosocial interventions to improve insight and reduce substance use. PMID:26657597

  18. Association of prominent positive and prominent negative symptoms and functional health, well-being, healthcare-related quality of life and family burden: a CATIE analysis.

    PubMed

    Rabinowitz, Jonathan; Berardo, Carmen Galani; Bugarski-Kirola, Dragana; Marder, Stephen

    2013-11-01

    There is an increased interest in evaluating the impact of core symptoms of schizophrenia, both positive and negative, on functioning and burden of disease. To examine the extent to which prominent positive and prominent negative symptoms impact functional health, well-being, health-related quality of life (HRQoL), and family burden. Data on symptomatology, HRQoL, and resource use from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) were analyzed (n=1447). Patients were divided into four groups based on the Positive and Negative Syndrome Scale (PANSS) using published criteria as having (a) neither prominent positive nor prominent negative symptoms (n=575; 39.7%); (b) only prominent negative symptoms (n=274; 18.9%); (c) only prominent positive symptoms (n=295; 20.4%); or (d) both prominent positive and negative symptoms (n=303; 20.9%). Differences were examined for overall significance between the groups and for a linear trend. There was a significant linear decline in the outcome measures with each subsequent symptom group, with the combination of prominent positive and negative symptoms incrementing the decline further on quality-adjusted life-years derived from the PANSS, Short-Form-12, Index of Functioning, HRQoL measures, and number of workdays missed by caregiver during the month prior to CATIE (all p<0.001). Both prominent positive and prominent negative symptoms of schizophrenia are independently associated with significant decline in functionality, HRQoL, and caregiver lost workdays. An increased burden is observed in patients with highest symptomatology. Further research is needed to determine predictors of poor outcomes and burden of schizophrenia. © 2013. Published by Elsevier B.V. All rights reserved.

  19. Lung histopathology, radiography, high-resolution computed tomography, and bronchio-alveolar lavage cytology are altered by Toxocara cati infection in cats and is independent of development of adult intestinal parasites.

    PubMed

    Dillon, A Ray; Tillson, D M; Hathcock, J; Brawner, B; Wooldridge, A; Cattley, R; Welles, B; Barney, S; Lee-Fowler, T; Botzman, L; Sermersheim, M; Garbarino, R

    2013-04-15

    This study presents clinical findings after oral ingestion of Toxocara cati eggs which resulted in rapid pulmonary lung migration and parenchymal disease, noted on clinically relevant diagnostic methods. Further, the study investigated the efficacy of pre-infection applications of preventative medication on larval migration through the lungs. A third aim of the study was to determine if adult cats infected with T. cati developed lung disease. Cats in infected groups were administered five oral doses of L3 T. cati larvae. Four-month-old specific pathogen free (SPF) kittens were divided into three groups (six per group): an infected untreated group, an uninfected untreated control group, and an infected treated group (topical moxidectin and imidacloprid, Advantage Multi for Cats, Bayer Healthcare LLC). Six 2- to 3-year-old adult multiparous female SPF cats were an infected untreated adult group. The cats were evaluated by serial CBCs, bronchial-alveolar lavage (BAL), fecal examinations, thoracic radiographs, and thoracic computed tomography (CT) scans and were euthanized 65 days after the initial infection. Adult T. cati were recovered in infected untreated kittens (5/6) and infected untreated adults (5/6) in numbers consistent with natural infections. Eggs were identified in the feces of most but not all cats with adult worm infections. No adult worms were identified in the uninfected controls or the infected treated group. All cats in the infected groups, including treated cats and untreated cats without adult worms, had lung pathology based on evaluation of radiography, CT scans, and histopathology. The infected cats demonstrated a transient peripheral eosinophilia and marked eosinophilic BAL cytology, but normal bronchial reactivity based on in vivo CT and in vitro ring studies. Lung lesions initially identified by CT on day 11 were progressive. Thoracic radiographs in infected cats had a diffuse bronchial-interstitial pattern and enlarged pulmonary arteries

  20. Thermal tolerance and potential distribution of Carvalhotingis visenda (Hemiptera: Tingidae), a biological control agent for cat's claw creeper, Macfadyena unguis-cati (Bignoniaceae).

    PubMed

    Dhileepan, K; Bayliss, D; Treviño, M

    2010-04-01

    The specialist tingid, Carvalhotingis visenda, is a biological control agent for cat's claw creeper, Macfadyena unguis-cati (Bignoniaceae). Cat's claw creeper is an invasive liana with a wide climatic tolerance, and for biological control to be effective the tingid must survive and develop over a range of temperatures. We evaluated the effect of constant temperatures (0-45 degrees C) on the survival and development of C. visenda. Adults showed tolerance for wider temperature ranges (0-45 degrees C), but oviposition, egg hatching and nymphal development were all affected by both high (>30 degrees C) and low (<20 degrees C) temperatures. Temperatures between 20 degrees C and 30 degrees C are the most favourable for adult survival, oviposition, egg hatching and nymphal development. The ability of adults and nymphs to survive for a few days at high (40 degrees C and 45 degrees C) and low (0 degrees C and 5 degrees C) temperatures suggest that extreme temperature events, which usually occur for short durations (hours) in cat's claw creeper infested regions in Queensland and New South Wales states are not likely to affect the tingid population. The potential number of generations (egg to adult) the tingid can complete in a year in Australia ranged from three to eight, with more generations in Queensland than in New South Wales.

  1. Enzyme-linked immunosorbent assays for coproantigen detection of Ancylostoma caninum and Toxocara canis in dogs and Toxocara cati in cats.

    PubMed

    Elsemore, David A; Geng, Jinming; Cote, Jennifer; Hanna, Rita; Lucio-Forster, Araceli; Bowman, Dwight D

    2017-09-01

    We report the development and field validation of 2 ELISAs for the detection of Ancylostoma caninum or Toxocara canis coproantigens in the feces of dogs with experimental and natural infections, and evidence of cross-reactivity with respective feline counterparts. A. caninum-specific coproantigens were detected in feces of experimentally infected dogs starting at 9 d post-infection (dpi), whereas eggs were not seen until 23 dpi. T. canis-specific coproantigens were detected in 3 of 5 experimentally infected dogs by 31 dpi, and 4 of the 5 animals by 38 dpi. T. canis eggs were seen in feces of 4 of the 5 animals by 38 dpi. One dog had delayed coproantigen detection and low egg output. Additionally, 817 canine and 183 feline fecal samples from naturally infected animals tested by flotation were subjected to coproantigen ELISA testing. Of these 1,000 canine and feline samples, 13 and 23 samples, respectively, were positive for "hookworm" or "roundworm" eggs; 19 and 26 samples were ELISA positive, respectively. The T. canis ELISA detected T. cati coproantigen in cat fecal samples. Discrepant ELISA and flotation results were obtained for 16 hookworm- and 13 roundworm-positive samples. Re-examination of the egg-positive, ELISA-negative samples indicated several instances of possible misidentification or coprophagy, whereas detection of antigen in samples without egg observations is likely a reflection of true infection status with egg shedding below detection levels. There is good indication, based on accumulated field data, that these antigen tests also detect other hookworm and ascarid species.

  2. Estudio teórico de la distribución catiónica en la capa octaédrica de silicatos laminares

    NASA Astrophysics Data System (ADS)

    Hernández-Laguna, A.

    Los silicatos laminares son unos minerales de gran extensión en la corteza de nuestro y otros planetas, y se ha detectado su presencia en masas de partículas de polvo interplanatario. Están formados por láminas estructuradas en una capa tetraedros de sílice y una de octaédros de oxihidroxido de aluminio. Según el número de capas y la disposición aparecen distintos minerales. Además, también pueden aparecer distintos minerales como consecuencia de la substitución isomórfica de cationes en la capas, en particular, Al(III) por Si en la capa tetraédrica y Fe(III) y/o Mg(II) por Al(III) en la octaédrica. Cuando el catión substituyente presenta un estado de oxidación más bajo que al que substituye genera carga negativa que tiene que neutralizarse con cationes que se disponen en el espacio interlaminar. En este trabajo vamos a estudiar, mediante distintos métodos computacionales, las distribuciones de dichos cationes de substitución en la capa octaédrica de silicatos laminares 2:1 (dos capas tetraédricas y en medio una octaédrica), en particular, en los minerales esmectitas e ilitas. En primer lugar, estudiaremos la distribución de dichos cationes en la capa octaédrica en un modelo de gas reticular por el método de Monte Carlo, minimizando el número de pares de cationes Al, Fe y Mg de nuestro modelo con respecto a los procedentes de resultados espectroscópicos de muestras de minerales. Posteriormente, y mediante un modelo de potenciales empíricos, estudiamos la energética de las distribuciones binarias en dichos minerales, generando unos potenciales de interacción intercambio a dos y tres cationes (extrapolables a cualquier filosilicato) que son la base para una investigación Monte Carlo-"simulated-annealing" en la que se encuentran las transiciones de fase y las estructuras ordenadas, dependiendo dichas estructuras y la temperatura de cambio de fase de la de la naturaleza y concentración de los cationes de substitución. También se han

  3. Visceral larva migrans—an immunofluorescent examination of rabbit and human sera for antibodies to the ES antigens of the second stage larvae of Toxocara canis, Toxocara cati and Toxascaris leonina (Nematoda)

    PubMed Central

    Hogarth-Scott, R. S.

    1966-01-01

    Precipitates were demonstrated in vitro at the orifices of the second stage larvae of Toxocara canis and T. cati when placed in sera derived from rabbits infected with these nematodes. Cross-reactions occurred between these two species. Furthermore, these precipitates occurring at the oral, excretory pore and the anal orifices of these larvae were shown to be of a specific antibody nature by the use of the direct fluorescent antibody (Coons) staining technique. The second stage larvae of Toxascaris leonina did not react in this way when examined in the above-mentioned experimental system, or in sera or globulins derived from rabbits infected with T. leonina. Human sera, taken from clinically suspect cases of visceral larva migrans, were examined in this manner (q.v.). Comparable results were obtained, and it was possible to determine whether fluorescent antibodies were present, and to use this information as an aid to the clinical diagnosis of this disease. The significance of these findings in relation to the aetiology, pathogenesis and immuno-diagnosis of visceral larva migrans is discussed. ImagesFIG. 1FIG. 2FIG. 3FIG. 4FIG. 5FIG. 6 PMID:5327555

  4. Common Aperture Techniques for Imaging Electro-Optical Sensors (CATIES).

    DTIC Science & Technology

    1980-02-01

    Feedback for the servo electronics and LED readout display signals are also obtained from these reference potentiometer voltages. The motor drive circuitry...Object Seoaration: .1927 inches IMA r;I;SEI’ARATION EFI. = 196 1/0 EFL SPEC. TN(󈧏t*..’) (1NCHIRS) *"(INCHES) VNtIV .031 31.53 31.5+0.63 N1󈧈 .01025

  5. Native AmerIndian Theor(h)etoric: The Periphery Speaks.

    ERIC Educational Resources Information Center

    Powell, Malea D.

    Rhetoric scholars must open space for the unheard counter-stories of American Indians, which exist alongside the echo of American-ness that implicates all people in this country. As the scholarly discourse of the academy itself is situated within a framework of the American narrative of conquest and imperialism, scholars must recognize that they…

  6. Genetic structure of faucet snail, Bithynia tentaculata populations in North Americal based on microsattelite markers

    USGS Publications Warehouse

    Perez, Kathryn E.; Werren, Rebecca L.; Lynum, Christopher A.; Hartman, Levi A.; Majoros, Gabor; Cole, Rebecca A.

    2016-01-01

    Bithynia tentaculata is believed to have been extirpated from North America during the last glacial maximum. It was reintroduced into North America via the Great Lakes basin in the 1800’s and has recently been expanding its geographic range. This snail serves as intermediate host for three trematodes that cause extensive recurring morbidity and mortality events in migratory water birds along the Mississippi River. Using twelve microsatellite loci for ~200 individual snails from 11 populations in North America and Europe, we examined one of the three major geographic regions from which founding populations into the Great Lakes typically originate. Our data supports a single recolonization of North America into the Great Lakes Basin followed by subsequent introduction events from the Great Lakes to other large watersheds in North America. However, additional watersheds in Europe require sampling to confirm this result. No populations with genetic signatures indicative of North American glacial relics were found. The initial invasion of North America was likely not from the Ponto-Caspian basin, the usual source of freshwater invasive species to the Laurentian Great Lakes.

  7. Preliminary Inventories: Vietnam War Collection, 23rd Infantry (Americal) Division, 1967-1971.

    DTIC Science & Technology

    1982-07-01

    too 0in06s WWuS "M USES eased ~.. Somd osm -dbdrV EIQDA Records Managemnt Division s.m-m 11S * now isral The Adjutant Cenerl’s Office NINE UAYU3U(Ch P ...Records Management Division 1 July 1982 Department of the Am (DARO-AMR- P ) 14 NUMBER OF PAGES Alexandria. Virginia 22331 203 14 MONITORING AGENCY NAME...A AODREII 19ferinI 1 CoR&Idbd 0Mmid) IS. SECURITY CLASS. W. SN. uqpslj Programs Branch (Records Management Division) Department of the Army (DAG-AMR- P

  8. A novel AMER1 frameshift mutation in a girl with osteopathia striata with cranial sclerosis.

    PubMed

    Enomoto, Yumi; Tsurusaki, Yoshinori; Harada, Noriaki; Aida, Noriko; Kurosawa, Kenji

    2017-10-09

    Osteopathia striata with cranial sclerosis (OSCS) (MIM #300373) is a rare X-linked dominant bone dysplasia characterized by cranial sclerosis and linear striations in the long bones of females, and fetal or neonatal lethality in affected males. This article is protected by copyright. All rights reserved.

  9. Detection and Avoidance of Mines and Boobytraps in South Vietnam -- Training and Tactical Procedures of the Americal Infantry Division

    DTIC Science & Technology

    1968-03-01

    ami Lcail». About the only thing you car. do when you first spot o!ie Is everybody just hit the ground because where you spot one there are quite...more. So, you spot one and you hit the ground. Normally the squad leader will be up there before the platoon leader or company commander gets there...You’ll find some mer; who have stumbled into four or five of them, and will never spot one . You make ammo bearers out of the men who can’t spot a

  10. All Prime Contract Awards by State or Country, Place, and Contractor. Part 22 (Aua Amer-Honduras)

    DTIC Science & Technology

    1990-01-01

    I 0-4NC4 d N N .4 N Y NNN N4 -I4 * w O-tN 4 I c.4 IE >4 E(N E C. > Eu E N ENNN E N 100Q EUQ a I0t cam a 2 02z z o ZZZ* o2 =Z =ZZZ* 02 022* 02 6 cor...40 0 4000 0 * 0 1 1 0~ 4C 0 00 0 C 0 00 0 00 W 1 00IN Coo .- 0 4 *.4) -0 4 *4 .4 0 0 04 I rn- 4 Wn i- 00 en en in en in Wne W W 11 I0. td p- 04 or-en

  11. Materials Data on CaTi4O8 (SG:8) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-09-30

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  12. Providing Sufficient Opportunity to Learn: A Response to Grehaigne, Caty and Godbout

    ERIC Educational Resources Information Center

    Slade, Dennis G.; Webb, Louisa A.; Martin, Andrew J.

    2015-01-01

    Background: Over the last 30 years, traditional skill-based game teaching models have gradually been supplemented by instruction under an inclusive banner of "Teaching Games for Understanding" (TGfU). This approach focuses on developing tactical understanding through modified games and a philosophy that places the learner rather than the…

  13. Materials Data on CaTi4(PO4)6 (SG:148) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2016-02-04

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  14. Providing Sufficient Opportunity to Learn: A Response to Grehaigne, Caty and Godbout

    ERIC Educational Resources Information Center

    Slade, Dennis G.; Webb, Louisa A.; Martin, Andrew J.

    2015-01-01

    Background: Over the last 30 years, traditional skill-based game teaching models have gradually been supplemented by instruction under an inclusive banner of "Teaching Games for Understanding" (TGfU). This approach focuses on developing tactical understanding through modified games and a philosophy that places the learner rather than the…

  15. Materials Data on Ca(TiS2)8 (SG:164) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-09-30

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  16. Land use as a Parameter of Distributed Hydrological Modeling at the CATIE Farm, Turrialba, Costa Rica.

    NASA Astrophysics Data System (ADS)

    Toohey, R.; Boll, J.; Brooks, E.; Jones, J.

    2007-05-01

    As distributed hydrological models continue to develop, their amount of spatial detail requires the evaluation of a larger set of variables. Deforestation is often cited as a principal cause of changing hydrological regimes in the tropics. However, many studies debate the exact mechanism of change. Also, much of the tropics have been permanently deforested for agricultural expansion. Therefore, in this study we instrumented fields (1-6 ha) of four common land uses (forest, coffee agroforestry, sugar cane, and pasture) with meteorological stations, soil moisture probes, and H-flumes. Additional field measurements have shown differences in bulk density, saturated hydraulic conductivity, and soil moisture dynamics between land uses. Hydrograph analysis suggests that the pasture site responds differently to rainfall than the other land uses. Runoff from the pasture site results in higher intensity, greater volume, and shorter duration runoff events than the other land uses. However, the other land uses respond more frequently with lower maximum event intensities, lower volumes and longer durations. In the forest and coffee sites, soil moisture dynamics suggest the importance of lateral preferential flow paths due to root influenced soil structure for runoff response. Therefore, while vertical Ksat values may be greater at all sites than most rainfall intensities, lateral Ksat values may differ significantly between sites. Field measurements and the distributed physically based Soil Moisture Routing (SMR) model are being used test hypotheses, and direct further field research. These results will prove important to understand hydrological connectivity in fragmented landscapes, and the potential recovery of hydrological services within a typical humid tropical environment.

  17. Materials Data on CaTi4O9 (SG:85) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2014-09-30

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  18. Latent class analysis of discordance between results of drug use assessments in the CATIE data

    PubMed Central

    Johnson, Kiersten L.; Desmarais, Sarah L.; Swartz, Marvin S.; Van Dorn, Richard A.

    2016-01-01

    Objective The primary aim is to examine concordant/discordant results of drug use assessments in adults with schizophrenia. Methods Latent class analysis and multinomial logistic regression were used to examine concordance/discordance between drug use measures and identify characteristics differentiating participants across classes. Results Four classes – non-users, users, probable users, and RIA discordant –fit best. Age, sex, race/ethnicity, and psychiatric symptoms differed significantly across classes. Conclusions Findings showed that discordance between results occurs at non-trivial rates and is, in part, attributable to individual characteristics. Results suggest the need for strategies to limit discordance and improve detection of drug use in adults with schizophrenia. PMID:25476120

  19. Drug and alcohol trajectories among adults with schizophrenia: Data from the CATIE Study

    PubMed Central

    Van Dorn, Richard A.; Desmarais, Sarah L.; Tueller, Stephen J.; Jolley, Jennifer M.; Johnson, Kiersten L.; Swartz, Marvin S.

    2013-01-01

    Objective The primary aim is to describe drug and alcohol trajectories in adults with schizophrenia. Method Growth mixture models were used to examine disordered and non-disordered use and abstinence in the Clinical Antipsychotic Trials of Intervention Effectiveness trial. Results Five classes—always abstinent; fluctuating use, abuse, and occasional abstinence; occasional (ab)use; stopped (ab)use; abusing—fit best. Overlap exists between always abstinent drug and alcohol classes; less overlap exists across other classes. Conclusion There is heterogeneity in drug and alcohol use among adults with schizophrenia. The lack of overlap between classes, save always abstinent, suggests modeling drug and alcohol use separately. PMID:23726721

  20. 2007. Two genes from Phaseolus coccineus L. confer resistance to Bean golden yellow mosaic virus in common bean. J. Amer. Soc. Hort. Sci. 132:530-533

    USDA-ARS?s Scientific Manuscript database

    Bean golden yellow mosaic virus (BGYMV), caused by a whitefly (Bemisia spp.) transmitted geminivirus, is an important disease that can limit common bean (Phaseolus vulgaris L.) production in Central America, the Caribbean and southern Florida. Only a few genes are currently deployed in BGYMV resista...

  1. Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial

    PubMed Central

    Chen, Li-Hua; Zhong, Chongke; Xu, Tan; Xu, Tian; Peng, Yanbo; Wang, Aili; Wang, Jinchao; Peng, Hao; Li, Qunwei; Ju, Zhong; Geng, Deqin; Zhang, Jintao; Li, Yongqiu; Zhang, Yonghong; He, Jiang

    2016-01-01

    The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored. Here, we investigated these associations in a prospective study from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline UA levels were measured in 3284 acute ischemic stroke patients. Primary outcome was defined as a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months. UA levels were significantly higher in men than women (310.6 ± 96.1 vs 257.5 ± 89.9 μmol/L, P < 0.001). The association between serum UA and the primary outcome was appreciably modified by sex (P-interaction = 0.007). After multivariate adjustment, a high serum UA was associated with a decreased risk of primary outcome in men [odds ratio (OR), 0.63; 95% confidence interval (CI), 0.44–0.91; P-trend = 0.01] but not in women (OR, 1.29; 95% CI, 0.83–2.01; P-trend = 0.15), when two extreme quartiles were compared. Subgroup and sensitivity analyses further confirmed these sex-specific findings. Our study indicated that there was a sex-specific association between serum UA and prognosis of acute ischemic stroke. Elevated serum UA was positively associated with better prognosis in men, but not in women. PMID:27901117

  2. Exposure to Echinococcus multilocularis, Toxocara canis, and Toxocara cati in Austria: a nationwide cross-sectional seroprevalence study.

    PubMed

    Poeppl, W; Herkner, H; Tobudic, S; Faas, A; Mooseder, G; Burgmann, H; Auer, H

    2013-11-01

    Despite emerging risks for the spread of zoonotic diseases, data on human exposure to Echinococcus multilocularis and Toxocara spp., the causative parasites of the two most important helminthozoonoses in Central Europe, are limited. To investigate risk factors and exposure, we conducted a nationwide, cross-sectional serological study in 1046 healthy individuals, of which 425 were soldiers and 621 were civilians. Serum samples and information on possible risk factors for exposure, including previous foreign military assignments, residential area, animal contact, and regular outdoor activities, were obtained. Immunoglobulin G antibodies against Echinococcus multilocularis and Toxocara spp. were examined with an enzyme-linked immunosorbent assay (ELISA). Samples reactive in the ELISA for antibodies against Echinococcus multilocularis were considered positive only after confirmation by western blot. Overall, 66 (6.3%) individuals tested positive in the serologic screening for Toxocara spp. Occupational animal contact was the only risk factor significantly associated with a higher risk for being seropositive. None of the individuals were positive for antibodies against Echinococcus multilocularis. In conclusion, the present study demonstrates that exposure to Toxocara spp. is widespread in Austria and occupational animal contact is a risk factor for seropositivity.

  3. Materials Data on CaTi2(CuO4)2 (SG:14) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2014-09-30

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  4. Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling.

    PubMed

    Brauburger, Katharina; Akyildiz, Senem; Ruppert, Jan G; Graeb, Michael; Bernkopf, Dominic B; Hadjihannas, Michel V; Behrens, Jürgen

    2014-02-01

    The adenomatous polyposis coli (APC) membrane recruitment (Amer) family proteins Amer1/Wilms tumour gene on the X chromosome and Amer2 are binding partners of the APC tumour suppressor protein, and act as negative regulators in the Wnt signalling cascade. So far, nothing has been known about the third member of the family, Amer3. Here we show that Amer3 binds to the armadillo repeat domain of APC, similarly to Amer1 and Amer2. Amer3 also binds to the Wnt pathway regulator conductin/axin2. Furthermore, we identified Amer1 as binding partner of Amer3. Whereas Amer1 and Amer2 are linked to the plasma membrane by an N-terminal membrane localization domain, Amer3 lacks this domain. Amer3 localizes to the cytoplasm and nucleus of epithelial cells, and this is dependent on specific nuclear import and export sequences. Functionally, exogenous Amer3 enhances the expression of a β-catenin/T-cell factor-dependent reporter gene, and knockdown of endogenous Amer3 reduces Wnt target gene expression in colorectal cancer cells. Thus, Amer3 acts as an activator of Wnt signalling, in contrast to Amer1 and Amer2, which are inhibitors, suggesting a nonredundant role of Amer proteins in the regulation of this pathway. Our data, together with those of previous studies, provide a comprehensive picture of similarities and differences within the Amer protein family. © 2013 FEBS.

  5. Exceptionally High Piezoelectric Coefficient and Low Strain Hysteresis in Grain-Oriented (Ba, Ca)(Ti, Zr)O3 through Integrating Crystallographic Texture and Domain Engineering.

    PubMed

    Liu, Yingchun; Chang, Yunfei; Li, Fei; Yang, Bin; Sun, Yuan; Wu, Jie; Zhang, Shantao; Wang, Ruixue; Cao, Wenwu

    2017-09-06

    Both low strain hysteresis and high piezoelectric performance are required for practical applications in precisely controlled piezoelectric devices and systems. Unfortunately, enhanced piezoelectric properties were usually obtained with the presence of a large strain hysteresis in BaTiO3 (BT)-based piezoceramics. In this work, we propose to integrate crystallographic texturing and domain engineering strategies into BT-based ceramics to resolve this challenge. [001]c grain-oriented (Ba0.94Ca0.06)(Ti0.95Zr0.05)O3 (BCTZ) ceramics with a texture degree as high as 98.6% were synthesized by templated grain growth. A very high piezoelectric coefficient (d33) of 755 pC/N, and an extremely large piezoelectric strain coefficient (d33* = 2027 pm/V) along with an ultralow strain hysteresis (Hs) of 4.1% were simultaneously achieved in BT-based systems for the first time, which are among the best values ever reported on both lead-free and lead-based piezoceramics. The exceptionally high piezoelectric response is mainly from the reversible contribution, and can be ascribed to the piezoelectric anisotropy, the favorable domain configuration, and the formation of smaller sized domains in the BCTZ textured ceramics. This study paves a new pathway to develop lead-free piezoelectrics with both low strain hysteresis and high piezoelectric coefficient. More importantly, it represents a very exciting discovery with potential application of BT-based ceramics in high-precision piezoelectric actuators.

  6. Structural properties of CaTi 1-x(Nb 2/3Li 2/3) xO 3-δ (CNLTO) and CaTi 1-x(Nb 1/2Ln 1/2) xO 3 (Ln=Fe (CNFTO), Bi (CNBTO)), modified dielectric ceramics for microwave applications

    NASA Astrophysics Data System (ADS)

    Costa, R. C. S.; Bruno Costa, A. D. S.; Freire, F. N. A.; Santos, M. R. P.; Almeida, J. S.; Sohn, R. S. T. M.; Sasaki, J. M.; Sombra, A. S. B.

    2009-05-01

    This paper presents an investigation of the structural characteristics of Nb 1/2Bi 1/2 (CNBTO), Nb 1/2Fe 1/2 (CNFTO) and Nb 2/3Li 1/3 (CNLTO) substitution into the B-site of calcium titanate ceramics. The modified CaTiO 3 (CTO) ceramics were prepared by the conventional solid-state method. The compounds were investigated, by X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDXS). The X-ray analysis shows that all samples have an orthorhombic structure. The refinement analysis of all samples were also performed and discussed in this paper. For all studied samples, a Raman mode at 805 cm -1 was detected and its intensity increases as the substitution increases. The dielectric permittivity and loss at microwave frequencies (MW) were investigated. The CNLTO phase, present the highest dielectric constant ( k=35.8) at 3.9 GHz with loss (tg α=7×10 -3). The lowest value of k=25.7 ( f=4.8 GHz) and tg α=3×10 -3, was obtained for the CNFTO phase. These measurements confirm the possible use of such material for microwave devices like dielectric resonator antennas.

  7. 75 FR 11890 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Interviewing (CATI) interface. The results of the survey shall be used for inpatient quality indicators (IQI...-programmed Computer-Assisted Telephone Interviewing (CATI) interface. Responses collected by Web will be...

  8. Quadrennial Review of Military Compensation (6th). Executive Summary. Volumes 1 thru 1C, and Volumes 2 thru 3

    DTIC Science & Technology

    1988-08-01

    the Idebat. on whiioh cat"Ovy. of ulte su Aor mporris the most coat-o1fective, and there have* been no easy anwr p either side ofd th 1:mquation. The... Native white Black Asian American Unknown Total Kale: None Asian Amer Indian Hispanic Other Unknown Subtotal. Female: None Asian Amer Indian Hispanic...Incentive Type By Component (Officers) Native White Black Asian American Unknown Total Noae: None Asian Amer Indian Hispanic Other Unknown Subtotal

  9. Environmental Support to Space Launch

    DTIC Science & Technology

    2006-05-31

    Bull. Amer. Meteor . Soc. 77, 2295-2305. - S. Businger, and M. Kaplan, 1997: Nowcasting convective activity for Space Shuffle landings during...at the Eastern Range and Kennedy Space Center. Preprints, Sixth Conference on Aviation Weather Systems, Dallas, TX, Amer. Meteor ., Soc., 135-140. Case...Meteorological Observations and Instrumentation, Long Beach, CA, Amer. Meteor . Soc., paper 7.1. Hazen, D., W. P. Roeder, B. Boyd, J. Lorens, and T

  10. A new species, Toxocara lyncis, in the caracal (Lynx caracal).

    PubMed

    Macchioni, G

    1999-12-01

    Toxocara lyncis, sp. n. is described from Lynx caracal in Somalia. It most closely resembles T. cati, the only species of Toxocara reported from L. caracal. It differs from T. cati in the comparative length of the spicules and the esophagus, and in the shape of the cervical alae. Cervical alae have a nearly uniform width along their length in T. lyncis, while they are narrow anteriorly and broad posteriorly forming an arrow head shaped cephalic end in T. cati.

  11. 21 CFR 520.903d - Febantel-praziquantel paste.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...), whipworms (Trichuris vulpis), ascarids (Toxocara canis and Toxascaris leonina), and tapeworms (Dipylidium...), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis). (3) Limitations. Do...

  12. 21 CFR 520.903d - Febantel-praziquantel paste.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...), whipworms (Trichuris vulpis), ascarids (Toxocara canis and Toxascaris leonina), and tapeworms (Dipylidium...), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis). (3) Limitations. Do...

  13. 21 CFR 520.903d - Febantel-praziquantel paste.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...), whipworms (Trichuris vulpis), ascarids (Toxocara canis and Toxascaris leonina), and tapeworms (Dipylidium...), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis). (3) Limitations. Do...

  14. 21 CFR 520.903d - Febantel-praziquantel paste.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...), whipworms (Trichuris vulpis), ascarids (Toxocara canis and Toxascaris leonina), and tapeworms (Dipylidium...), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis). (3) Limitations. Do...

  15. 21 CFR 520.903d - Febantel-praziquantel paste.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...), whipworms (Trichuris vulpis), ascarids (Toxocara canis and Toxascaris leonina), and tapeworms (Dipylidium...), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis). (3) Limitations. Do...

  16. 21 CFR 524.1146 - Imidacloprid and moxidectin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...); kills adult fleas and treats flea infestations (Ctenocephalides felis). (2) Cats—(i) Amount. Topically... (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations...

  17. 21 CFR 524.1146 - Imidacloprid and moxidectin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...); kills adult fleas and treats flea infestations (Ctenocephalides felis). (2) Cats—(i) Amount. Topically... (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations...

  18. 21 CFR 524.1146 - Imidacloprid and moxidectin.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...); kills adult fleas and treats flea infestations (Ctenocephalides felis). (2) Cats—(i) Amount. Topically... (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations...

  19. 21 CFR 524.1146 - Imidacloprid and moxidectin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...); kills adult fleas and treats flea infestations (Ctenocephalides felis). (2) Cats—(i) Amount. Topically... (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations...

  20. Selective Observation of Elastic-Body Resonances via Their Ringing in Transient Acoustic Scattering.

    DTIC Science & Technology

    1984-09-12

    evident but have not been discussed by him. Subsequent studies of pulse scattering from rigid spheres by Rudgers 3 , or from elastic 4 cylinders by Veksler...Lucite 1.182 2680 1380 1. J. J. Faran, J "" - -’,:. Amer. 23, 405 (1951) 2. R. Hicklinc, J. ,w.L t. Soc. Amer. 34, 1582 (1962). 3. A. J. Rudgers , J

  1. Female Combat Medics Fight Every Day & Earn Respect

    ERIC Educational Resources Information Center

    Alberts, Mike

    2007-01-01

    Temperatures exceeded 115 degrees on July 11 during the five-hour mission in the city of Amerli. More than 50 soldiers were on site and tensions were high; Amerli was the scene of a massive suicide truck bombing just four days earlier. Soldiers kept alert but visibly struggled under the weight of dozens of pounds of battle gear. Throughout the…

  2. Female Combat Medics Fight Every Day & Earn Respect

    ERIC Educational Resources Information Center

    Alberts, Mike

    2007-01-01

    Temperatures exceeded 115 degrees on July 11 during the five-hour mission in the city of Amerli. More than 50 soldiers were on site and tensions were high; Amerli was the scene of a massive suicide truck bombing just four days earlier. Soldiers kept alert but visibly struggled under the weight of dozens of pounds of battle gear. Throughout the…

  3. A Three-Component Seismic Refraction Survey in Northwestern Arizona

    DTIC Science & Technology

    1989-01-31

    United States. Amer. J. of ScL 272:97-118. 19. Burchflel, B.C. and Davis. G.A. (1975) Nature and Controls of the Cordilleran Orogenesis , Western United...1975) Nature and Controls of the Cordilleran Orogenesis , Western United States - Extensions of an Earlier Synthesis, Amer. J. of ScL 275-k275. 20

  4. A Study of the Halogenation of Aliphatic Hydrocarbons and Derivatives Thereof

    DTIC Science & Technology

    1961-08-01

    Arlingt 12, Virginia. This report has been released to the Office of Technical Services, U. S. Department of Com- merce, Washington 25, D. C. for sale ...J.Amer.Chem.Soc., 1928, 50, 1427. 17. Fargher and Perkin, J.Chem.Soc., 1914, 1_0, 1353. 18. Henne, J.Amer.Chem.Soc., 1938, 60, 1569. 19. Edgell and

  5. Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.

    PubMed

    Griffin, Nicholas W; Ahern, Philip P; Cheng, Jiye; Heath, Andrew C; Ilkayeva, Olga; Newgard, Christopher B; Fontana, Luigi; Gordon, Jeffrey I

    2017-01-11

    Ensuring that gut microbiota respond consistently to prescribed dietary interventions, irrespective of prior dietary practices (DPs), is critical for effective nutritional therapy. To address this, we identified DP-associated gut bacterial taxa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or without dietary restrictions (AMER). When transplanted into gnotobiotic mice, AMER and CRON microbiota responded predictably to CRON and AMER diets but with variable response strengths. An individual's microbiota is connected to other individuals' communities ("metacommunity") by microbial exchange. Sequentially cohousing AMER-colonized mice with two different groups of CRON-colonized mice simulated metacommunity effects, resulting in enhanced responses to a CRON diet intervention and changes in several metabolic features in AMER animals. This response was driven by an influx of CRON DP-associated taxa. Certain DPs may impair responses to dietary interventions, necessitating the introduction of diet-responsive bacterial lineages present in other individuals and identified using the strategies described.

  6. MNDO-Estimations of the Standard Enthalpy of Formation of Some Binary Sulfur-Nitrogen Compounds and Their Derivatives.

    DTIC Science & Technology

    1982-02-01

    1976, 31, 403. Adkins, R. R.; Turner, A. G., J. Amer. Chem. Soc., 1978, 100, 1383. Bhattacharyya, A. A.; Battacharyya , A.; Turner, A. G., Inorg. Chim...Pratt, D . W.; Myers, R. J., J. Amer. Chem. Soc., 1969, 91, 6623. For S2N 2 open chain; this is a likely inter- mediate in the polymerization of...Amer. Chem. Soc., 1977, 99, 4899. Bingham, R.; Dewar, M.J.S.; Lo, D . H., ibid, 1975, 97, 1285, 194, 1302, 1307. 6 6. Pople, J. A.; Nesbet, R. K., Chem

  7. 75 FR 17396 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... vaccine component against scrub typhus'', Inventors: Wei Mei Ching and Chien Chung Chao, issued May 13... material'', Inventors: Amer Tiba, David Charlton, and James Ragain, issued January 29, 2010; 7,673,746...

  8. Science off the Sphere: Space Balloonacy

    NASA Image and Video Library

    In his off duty time, NASA Astronaut Don Pettit cools down with some microgravity water balloon experiments aboard the International Space Station. Through a partnership between NASA and the Americ...

  9. Contributions to the Mosquito Fauna of Southeast Asia. VII. Genus Aedeomyia Theobald in Southeast Asia

    DTIC Science & Technology

    1970-01-01

    Cdomyia Aedes africana Anophele s Azolla catasticta Centropus crassipes Eichhornia furfurea Lepiothauma Lepisthauma M yr iophyllum... crassipes (Standfast & Barrow 1968: 427). Hamon (1966: 372) records aflicana with 6 Contrib. Amer. Ent. Inst., vol. 6, no. 2, 1970 dense Pistiu

  10. The Horizontal Extent of Lightning Based on Altitude and Atmospheric Temperature

    DTIC Science & Technology

    2007-11-02

    forecast, continue to follow existing guidance for maintaining … 5 NM [nautical mile] separation from heavy rain showers .” The first question that...positive cloud-to-ground lightning. Mon. Wea. Rev., 118, 470-487. Glickman, T. S., Ed., 2000: Glossary of Meteorology. Amer. Meteor . Soc., 855 pp...and interpretation of three- dimensional lightning flash information. Proc. 80th Amer. Meteor . Soc. Meeting, Long Beach, CA. NASA, cited 2001

  11. Severe Weather Forecasting for Laughlin AFB, TX

    DTIC Science & Technology

    2007-03-01

    showers is assumed to be of weaker intensity, while DMC that culminates in thunderstorms is assumed to be of stronger intensity.” Deep moist convection...FL, Amer. Meteor . Soc., 547-550. ______, R. E. Jewell, and H. E. Brooks, 2002: Comparison between observed convective cloud base heights and...11th Conf. on Severe Local Storms, Kansas City, MO, Amer. Meteor . Soc., 397-402. 80 _____, F. Caracena and M. Magnano, 1985: Temporal evolution of

  12. Climate Analysis of Lightning Launch Commit Criteria for Kennedy Space Center and Cape Canaveral Air Force Station

    DTIC Science & Technology

    2010-03-01

    showers and thunderstorms across the Florida Peninsula including at KSC/CCAFS (Hodanish et al. 1997). 7 3. Summer (Jun-Aug) The Bermuda High...Lightning Data, Atlanta, GA, Amer. Meteor . Soc., 9 pp. Earth Systems Research Laboratory (ESRL), cited 2010. [Accessed online at http...S., Ed., 2000: Glossary of Meteorology. 2d ed. Amer. Meteor . Soc., 855 pp. Goetz, E. C., 2001: Descriptive and conditional climatology for specific

  13. Environmental Aspects of Artificial Aeration and Oxygenation of Reservoirs: A Review of Theory, Techniques, and Experiences.

    DTIC Science & Technology

    1982-05-01

    pumping. (W. H. Irwin, J. M. Symons, and G. G. Robeck). J. Sanit . Eng. Div., Amer. Soc. Civil Eng. 93:141-143. American Water Works Association. 1971...quality. Proc. Symp. on Effects of Storage on Water Quality, Water Res. Centre, Medmenham, England . Bernhardt, H. 1967. Aeration of Wahnbach Reservoir...Cox Hollow Lake, Wisconsin, following destratification. J. Sanit . Eng. Div., Amer. Soc. Civil Eng. 95:929-940. Brock, T.D. 1973. Lower pH limit for the

  14. Smoothest Local Interpolation Formulas for Equally Spaced Data.

    DTIC Science & Technology

    1981-08-01

    REFERENCES [1] T. N. E. Greville, The general theory of osculatx’ry interpolation, Trans. Actuar . Soc. Amer., 45 (1944), 202-265. [2] T. N. E...1969. [31 T. N. E. Greville and H. Vaughan, Polynomial interpolation in terms of symbolic operators, Trans. Soc. Actuar ., 6 (1954), 413-476. [4] R...Henderson, A practical interpolation formula, Trans. Actuar . Soc. Amer., 9 (1906), 211-224. [5] W. A. Jenkins, Graduation based on a modification of

  15. The Coordinated Noninvasive Studies (CNS) Project. Phase 1. Appendices

    DTIC Science & Technology

    1991-12-01

    sounds : absolute -nd relative ear advantages. Journal of the Acoustical So;ety of Americ 71, 701-707. Lauter, J.L. (1983) Stimulus characteristics ...71-74. 1980 "Dichotic identification of complex sounds ," to Acoustical Society of America, Atlanta. Abstract: J Acoust Soc Amer 67: S100. 1981...establishing a baseline for experiments on brain asymmetries and complex sounds in the CNS Project" (with E. Plante), to Acoustical Society of

  16. Expect the Unexpected: A Case of Isolated Eosinophilic Meningitis in Toxocariasis

    PubMed Central

    Sick, Christian; Hennerici, Michael G.

    2014-01-01

    We present the case of a young police officer suffering from headache without other neurological symptoms caused by isolated eosinophilic meningitis, which resulted from an infection with Toxocara cati, along with a discussion of the differential diagnosis. PMID:25535488

  17. 75 FR 16737 - Proposed Information Collection; Comment Request; Generic Clearance for Questionnaire Pretesting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... interviews, focus groups, respondent debriefing, behavior coding of respondent/interviewer interaction, and..., face-to- face, paper-and-pencil, CATI, CAPI, Internet, or IVR. III. Data OMB Number: 0607-0725. Form...

  18. Toxocariasis (For Parents)

    MedlinePlus

    ... an infection caused by the larvae of parasitic worms — Toxocara canis and Toxocara cati — that usually live ... intestines of dogs and cats. Eggs from the worms pass into the feces of dogs and cats ...

  19. HINTS Puerto Rico: Final Report

    Cancer.gov

    This final report describes HINTS implementation in Puerto Rico. The report addresses sampling; staffing, training and management of data collection; calling protocol; findings from the CATI Operations, and sample weights.

  20. [The spread of nematodes from Toxocara genus in the world].

    PubMed

    Borecka, Anna

    2010-01-01

    Twenty seven species belong to the genus Toxocara. Most of the species infect Carnivora from families: Canidae, Felidae, Viverridae, Procyonidae, Mustelidae and Herpestidae. The most widespread species are: T. canis, T. cati and T. vitulorum. The life cycle of Toxocara spp. is connected with young animals and adults with the lowered immune response. Three of the Toxocara species: T. canis, T. cati and T. pteropodis are the aetiological agents of human toxocariasis.

  1. The Army Communications Objectives Measurement System (ACOMS): Parental User’s Manual

    DTIC Science & Technology

    1988-07-01

    position and distinctive advantages vis-a-vis civilian alternatives (i.e., college and civilian employment). This information helps the Army make...interviews, and (b) information regarding the flow and control of the instruments administered to respondents. Questionnaire wording is broadly defined...questions, or predetermined selection criteria. Like skip patterns, CATI checks control the flow of the interview. However, CATI checks can be used

  2. A comparison of survey techniques on sensitive sexual behavior in Italy.

    PubMed

    Caltabiano, Marcantonio; Dalla-Zuanna, Gianpiero

    2013-01-01

    This article compares two national surveys carried out through the most commonly used procedures in Italy: CATI (computer-assisted telephone interviews) and SAQ-FI (self-answered questionnaires following interviews). Both surveys ask two identical questions concerning sensitive sexual behavior: early age at first intercourse and same-sex attraction. The SAQ-FI survey had both unit non-response and item non-response rates much lower than the CATI survey. Moreover, in the CATI survey, the groups with highest item non-response rates were also the groups with the lowest proportions of early intercourse and homosexual attraction. In addition, a differential analysis of the respondents produced diverse results for the two surveys. This is especially true of results by gender for same-sex attraction: Such behavior is more common among men (3.1%) than women (2.9%), according to the CATI survey, whereas the opposite is true of the SAQ-FI survey (6.1% of men vs. 7.7% women). In Italy at the beginning of the 21st century, CATI surveys reveal a lower level of early intercourse and same-sex attraction than SAQ-FI surveys. This article argues that the CATI survey underestimates the true level of these sensitive sexual behaviors in the Italian population.

  3. Differential gene expression by Moniliophthora roreri while overcoming cacao tolerance in the field.

    PubMed

    Bailey, Bryan A; Melnick, Rachel L; Strem, Mary D; Crozier, Jayne; Shao, Jonathan; Sicher, Richard; Phillips-Mora, Wilberth; Ali, Shahin S; Zhang, Dapeng; Meinhardt, Lyndel

    2014-09-01

    Frosty pod rot (FPR) of Theobroma cacao (cacao) is caused by the hemibiotrophic fungus Moniliophthora roreri. Cacao clones tolerant to FPR are being planted throughout Central America. To determine whether M. roreri shows a differential molecular response during successful infections of tolerant clones, we collected field-infected pods at all stages of symptomatology for two highly susceptible clones (Pound-7 and CATIE-1000) and three tolerant clones (UF-273, CATIE-R7 and CATIE-R4). Metabolite analysis was carried out on clones Pound-7, CATIE-1000, CATIE-R7 and CATIE-R4. As FPR progressed, the concentrations of sugars in pods dropped, whereas the levels of trehalose and mannitol increased. Associations between symptoms and fungal loads and some organic and amino acid concentrations varied depending on the clone. RNA-Seq analysis identified 873 M. roreri genes that were differentially expressed between clones, with the primary difference being whether the clone was susceptible or tolerant. Genes encoding transcription factors, heat shock proteins, transporters, enzymes modifying membranes or cell walls and metabolic enzymes, such as malate synthase and alternative oxidase, were differentially expressed. The differential expression between clones of 43 M. roreri genes was validated by real-time quantitative reverse transcription polymerase chain reaction. The expression profiles of some genes were similar in susceptible and tolerant clones (other than CATIE-R4) and varied with the biotrophic/necrotropic shift. Moniliophthora roreri genes associated with stress metabolism and responses to heat shock and anoxia were induced early in tolerant clones, their expression profiles resembling that of the necrotrophic phase. Moniliophthora roreri stress response genes, induced during the infection of tolerant clones, may benefit the fungus in overcoming cacao defense mechanisms. © 2014 BSPP AND JOHN WILEY & SONS LTD.

  4. Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence: A Case of the Emperor's New Clothes?

    PubMed Central

    Jayaram, Mahesh; Rattehalli, Ranganath D.; Adams, Clive E.

    2012-01-01

    Advent of “atypical” antipsychotics has spawned new trials in the recent years and the number of such trial reports has been increasing exponentially. As clinicians we have been led to believe that “atypicals” are better than “typicals” despite the odd dissenting voice in academic and clinical circles. This has been largely ignored until the publication of two landmark, independent, pragmatic trials, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS), which proved that thoughtfully chosen “typical” antipsychotics were as good as the newer “atypicals.” We pooled “leaving the study early data” from Cochrane Reviews that existed before CATIE and CUtLASS and added data from CATIE and CUtLASS to the pool for a “before and after” comparison. Addition of CATIE and CUtLASS data only led to narrowing of the already existing confidence intervals, merely increasing precision, and decreasing the risk of Type II error. Perhaps surprisingly, CATIE and CUtLASS when pooled with the already existing data showed us that we had chosen to turn a blind eye to findings that already existed. This leads clinicians to question as to whether, in future, we need to feel less guilty about crying out early on that the emperor has no clothes on. PMID:22966441

  5. Ascarid infestation in captive Siberian tigers in China.

    PubMed

    Peng, Zhiwei; Liu, Shijie; Hou, Zhijun; Xing, Mingwei

    2016-08-15

    The Siberian tiger is endangered and is listed by the International Union for the Conservation of Nature; the captive environment is utilized to maintain Siberian tiger numbers. Little information regarding the prevalence of parasites in Siberian tigers is available. A total of 277 fecal samples of Siberian tigers were analyzed in this study. The microscopic analysis indicated the presence of ascarid eggs of Toxascaris leonina and Toxocara cati. The ascarid infection rate was 67.5% in Siberian tigers. The internal transcribed spacer-1 (ITS-1) phylogenetic analysis indicated that T. leonina belonged to Toxascaris and that Toxo. cati belonged to Toxocara. The infestation rate and intensity of T. leonina were higher than those of Toxo. cati. One-way analysis of variance showed that the presence of T. leonina was significantly associated with age (P<0.05). Temperature changes also influenced T. leonina and Toxo. cati infestation, and a rise in temperature caused an increase in the number of T. leonina and Toxo. cati eggs. This study provides a better understanding of ascarid infestation among the captive Siberian tigers and is helpful for the prevention of the spread of infectious parasitic diseases among other tigers in the zoo. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Capsicum annuum L. trypsin inhibitor as a template scaffold for new drug development against pathogenic yeast.

    PubMed

    Ribeiro, Suzanna F F; Silva, Marciele S; Da Cunha, Maura; Carvalho, André O; Dias, Germana B; Rabelo, Guilherme; Mello, Erica O; Santa-Catarina, Claudete; Rodrigues, Rosana; Gomes, Valdirene M

    2012-03-01

    A 6,000 Da peptide, named CaTI, was isolated from Capsicum annuum L. seeds and showed potent inhibitory activity against trypsin and chymotrypsin. The aim of this study was to determine the effect of CaTI on Saccharomyces cerevisiae, Candida albicans, Candida tropicalis and Kluyveromyces marxiannus cells. We observed that CaTI inhibited the growth of S. cerevisiae, K. marxiannus as well as C. albicans and induced cellular agglomeration and the release of cytoplasmic content. No effect on growth was observed in C. tropicalis but morphological changes were noted. In the spot assay, different degrees of sensitivity were shown among the strains and concentrations tested. Scanning electron microscopy showed that S. cerevisiae, K. marxiannus and C. albicans, in the presence of CaTI, exhibited morphological alterations, such as the formation of pseudohyphae, cellular aggregates and elongated forms. We also show that CaTI induces the generation of nitric oxide and interferes in a dose-dependent manner with glucose-stimulated acidification of the medium mediated by H(+)-ATPase of S. cerevisiae cells.

  7. Opening Switch Research on a Plasma Focus VI.

    DTIC Science & Technology

    1988-02-26

    and Control Nucl. Fusion Res., 121 (IAEA, Vienna, 1969). 35. V. F. D’yachenko and V. S. Imshennik, Sov . Phys . JETP 29, 947 (1969). 36. D. E. Potter...20. Phys . JETP Lett . 15, 232 (1972). 20. K. Boulais, G. Gerdin, and F. Venneri, Bult. Amer. Phys . Soc. 31, 1456 (1986). 21. F. Venneri, H. Krompholz...IAEA, 1985 ). 8. T. Oppenlaender, G. Pross, G. Decker and M. Truck, Plasma Phys . 19, 1075 (1977). 9. D. L. Jassby, Trans. Amer. Nucl. Soc. 30, 61

  8. Campaigns and Operations: Selected Bibliographies

    DTIC Science & Technology

    1989-04-01

    D769.295 Cronin, Francis D. Under the Southern Cross: the Saga of the .A5C7 Americal Division. Washington: Combat Forces Press, 1951. 432 pp. (See...341-389; see also index: Leyte) v.5 D)769.295 Cronin, lFrancis D. Under the Southern Cross; The Saga of the Americal .A5C7 Division. Washington: Combat...1964. 392 pp. (See pages 269-305, General Erich Ludendorff) I)K260 Charques, Richard I). ’he Twilight of Imperial Russia. London: Oxford .C37

  9. Deterministic Models of Channel Headwall Erosion: Initiation and Propagation

    DTIC Science & Technology

    1991-06-14

    Port Ocean Div., Amer. Soc. Civil Engr. 106(WW3):369-389. Beltaos , S . 1976 Oblique impingement of plane turbulent jets. J. Hydr. Div. Amer. Soc. Civil...Engrs. 102(HY9): 1177-1192. Beltaos , S . and Rajaratnam. 1973. Plane turbulent impinging jets. J. Hydr. Res. 11:29-59. Bradford, J. M. and R. F. Priest...June 14, 1991 FINAL 7!5T Oy7- /%faq 4. TITLE AND SUBTITLE S . FUNDING NUMB ERS Deterministic Models of Channel Headwall Erosion: Initiation and

  10. A Hybrid Method for Paraxial Beam Propagation in Multimode Optical Waveguides.

    DTIC Science & Technology

    1980-01-01

    generalization to waveguides of circular symmetry. P-I REFERENCES [1] D. Marcuse , Theory of Dielectric Optical Waveguides. New York: Academic Press, 1974, ch...Gaussian beams in multimode fiber guides," J. Opt. Soc. Amer. vol. 68 , pp. 989-993 (1978). [5] M.D. Feit and J.A. Fleck, "Light propagation in graded...1978). [22] R. Ulrich and T. Kamiya, "Resolution of self-images in planar optical waveguides," J. Opt. Soc. Amer. vol. 68 , pp, 583-592 (1978). [23

  11. Identification of a third feline Demodex species through partial sequencing of the 16S rDNA and frequency of Demodex species in 74 cats using a PCR assay.

    PubMed

    Ferreira, Diana; Sastre, Natalia; Ravera, Iván; Altet, Laura; Francino, Olga; Bardagí, Mar; Ferrer, Lluís

    2015-08-01

    Demodex cati and Demodex gatoi are considered the two Demodex species of cats. However, several reports have identified Demodex mites morphologically different from these two species. The differentiation of Demodex mites is usually based on morphology, but within the same species different morphologies can occur. DNA amplification/sequencing has been used effectively to identify and differentiate Demodex mites in humans, dogs and cats. The aim was to develop a PCR technique to identify feline Demodex mites and use this technique to investigate the frequency of Demodex in cats. Demodex cati, D. gatoi and Demodex mites classified morphologically as the third unnamed feline species were obtained. Hair samples were taken from 74 cats. DNA was extracted; a 330 bp fragment of the 16S rDNA was amplified and sequenced. The sequences of D. cati and D. gatoi shared >98% identity with those published on GenBank. The sequence of the third unnamed species showed 98% identity with a recently published feline Demodex sequence and only 75.2 and 70.9% identity with D. gatoi and D. cati sequences, respectively. Demodex DNA was detected in 19 of 74 cats tested; 11 DNA sequences corresponded to Demodex canis, five to Demodex folliculorum, three to D. cati and two to Demodex brevis. Three Demodex species can be found in cats, because the third unnamed Demodex species is likely to be a distinct species. Apart from D. cati and D. gatoi, DNA from D. canis, D. folliculorum and D. brevis was found on feline skin. © 2015 ESVD and ACVD.

  12. Salicylic acid is a modulator of catalase isozymes in chickpea plants infected with Fusarium oxysporum f. sp. ciceri.

    PubMed

    Gayatridevi, S; Jayalakshmi, S K; Sreeramulu, K

    2012-03-01

    The relationship between salicylic acid level catalases isoforms chickpea cv. ICCV-10 infected with Fusarium oxysporum f. sp. ciceri was investigated. Pathogen-treated chickpea plants showed high levels of SA compared with the control. Two isoforms of catalases in shoot extract (CAT-IS and CAT-IIS) and single isoform in root extract (CAT-R) were detected in chickpea. CAT-IS and CAT-R activities were inhibited in respective extracts treated with pathogen whereas, CAT-IIS activity was not inhibited. These isoforms were purified and their kinetic properties studied in the presence or absence of SA. The molecular mass determined by SDS-PAGE of CAT-IS, CAT-IIS and CAT-R was found to be 97, 40 and 66 kDa respectively. Kinetic studies indicated that Km and V(max) of CAT-IS were 0.2 mM and 300 U/mg, 0.53 mM and 180 U/mg for CAT-IIS and 0.25 mM and 280 U/mg for CAT-R, respectively. CAT-IS and CAT-R were found to be more sensitive to SA and 50% of their activities were inhibited at 6 and 4 μM respectively, whereas CAT-IIS was insensitive to SA up to 100 μM. Quenching of the intrinsic tryptophan fluorescence of purified catalases were used to quantitate SA binding; the estimated K(d) value for CAT-IS, CAT-IIS and CAT-R found to be 2.3 μM, 3.1 mM and 2.8 μM respectively. SA is a modulator of catalase isozymes activity, supports its role in establishment of SAR in chickpea plants infected with the pathogen.

  13. Notoedric mange in two free-ranging North American racoons (Procyon lotor) in Japan.

    PubMed

    Ninomiya, Hiroyoshi; Ogata, Munetsugu

    2002-04-01

    Mange was diagnosed in two North American racoons (Procyon lotor) at Kamakura City in Kanagawa Prefecture, Japan. The mites were identified morphologically as Notoedres cati. Mite infestation affected the skin over the extremities and tail, and was characterized by moderate alopecia and erythematous dermatosis. Histopathologically, the affected skin showed marked epidermal hyperplasia and mites located within the parakeratotic stratum corneum. A slight dermal inflammatory response consisting principally of mononuclear cells was observed. N. cati mites were demonstrated in their tunnels using scanning electron microscopy (SEM). This is the first report of notoedric mange in racoons.

  14. Measurements at Los Alamos National Laboratory Plutonium Facility in Support of Global Security Mission Space

    SciTech Connect

    Stange, Sy; Mayo, Douglas R.; Herrera, Gary D.; McLaughlin, Anastasia D.; Montoya, Charles M.; Quihuis, Becky A.; Trujillo, Julio B.; Van Pelt, Craig E.; Wenz, Tracy R.

    2012-07-13

    The Los Alamos National Laboratory Plutonium Facility at Technical Area (TA) 55 is one of a few nuclear facilities in the United States where Research & Development measurements can be performed on Safeguards Category-I (CAT-I) quantities of nuclear material. This capability allows us to incorporate measurements of CAT-IV through CAT-I materials as a component of detector characterization campaigns and training courses conducted at Los Alamos. A wider range of measurements can be supported. We will present an overview of recent measurements conducted in support of nuclear emergency response, nuclear counterterrorism, and international and domestic safeguards. This work was supported by the NNSA Office of Counterterrorism.

  15. POLICY OPTIONS TO REVERSE THE DECLINE OF WILD PACIFIC SALMON

    EPA Science Inventory

    The primary goal of the Salmon 2100 Project was to identify practical options that have a high probability of maintaining biologically significant, sustainable populations of wild salmon in the Pacific Northwest and California. Wild salmon recovery efforts in western North Americ...

  16. A complete plastid phylogeny of Daucus – concordance to nuclear results, and markers necessary for phylogenetic resolution

    USDA-ARS?s Scientific Manuscript database

    Premise of study: Our purposes were to (1) obtain a well-resolved plastid counterpart to the 94 gene nuclear ortholog gene phylogeny of Arbizu et al. (2014, Amer. J. Bot. 101:1666-1685; and Syst. Bot., in press), and (2) to investigate various classes and numbers of plastid markers necessary for a c...

  17. ARMA Estimators of Probability Densities with Exponential or Regularly Varying Fourier Coefficients.

    DTIC Science & Technology

    1987-06-01

    of the smoothing parameter of fn (’m) (see Hart 1985 and Diggle and Hall 1986 for more on this subject). The integrated squared errors of the cross...Statist. 5 530-535. Diggle , P.J. and Hall, P. (1986). The selection of terms in an orthogonal series density estimator. J. Amer. Statist. Assoc. 81 230-233

  18. Robust Fixed-Structure Control

    DTIC Science & Technology

    1994-10-30

    Deterministic Foundation for Statistical Energy Analysis ," J. Sound Vibr., to appear. 1.96 D. S. Bernstein and S. P. Bhat, "Lyapunov Stability, Semistability...S. Bernstein, "Power Flow, Energy Balance, and Statistical Energy Analysis for Large Scale, Interconnected Systems," Proc. Amer. Contr. Conf., pp

  19. Hurricane Isabel (2003): New Insights into the Physics of Intense Storms. Part 2. Extreme Localized Wind

    DTIC Science & Technology

    2006-10-01

    NCAR GPS drop- windsonde. Bull. Amer. Meteor. Soc., 80, 407–420. Jorgensen, D. P., P. H. Hildebrand, and C. L. Frush, 1983: Feasibility test of an...Hurricane Erin. Mon. Wea. Rev., 134, 1036–1038. Black, M. L., R. W. Burpee , and F. D. Marks, 1996: Vertical motion characteristics of tropical cyclones

  20. Ecological Assessment of the Effects of Army Training Activities on a Desert Ecosystem. National Training Center, Fort Irwin, California

    DTIC Science & Technology

    1985-06-01

    Quantum Evolution," Evolution, Vol. 21 (1967), pp 201-209. 6. Axelrod, D. I., "Edaphic Aridity as a Factor in Angiosperm Evolution," Amer. Natur., Vol...Raven, P. H., and D. I. Axelrod, " Angiosperm Biogeography and Past Continental Movements," Ann. Missouri Bot. Gard., Vol. 61 (1974), pp 539-673. 97

  1. Catalog and Illustrated Review of the Subgenus Melanoconion of Culex (Diptera: Culicidae) (Contributions of the American Entomological Institute. Volume 27, Number 2, 1992)

    DTIC Science & Technology

    1992-01-01

    de Entomologia Taxonomica, Division de Endemias Rurales, Maracay, Venezuela Section de Entomologia, Departamento de Parasitologia y Microbiologia ...Paulo, Brazil Faculdade de Saude Publica, Universidade de Sao Paulo, Brazil Instituto National de Microbiologia , Carlos G. Malbran, Buenos Aires...Publication de la 84 Contrib. Amer. Ent. Inst., Vol. 27, No. 2, 1992 Division de Endemias Rurales, Direction de Malariologia y Saneamiento Ambiental

  2. A Simple Method to Find out when an Ordinary Differential Equation Is Separable

    ERIC Educational Resources Information Center

    Cid, Jose Angel

    2009-01-01

    We present an alternative method to that of Scott (D. Scott, "When is an ordinary differential equation separable?", "Amer. Math. Monthly" 92 (1985), pp. 422-423) to teach the students how to discover whether a differential equation y[prime] = f(x,y) is separable or not when the nonlinearity f(x, y) is not explicitly factorized. Our approach is…

  3. Tolerance of Swallowworts (Vincetoxicum spp.) to multiple years of artificial defoliation and clipping

    USDA-ARS?s Scientific Manuscript database

    The European vines, pale swallowwort (Vincetoxicum rossicum) and black swallowwort (V. nigrum), are invading various habitats in northeastern North America. It is unclear how these plants might respond to potential biological control agents, as they experience little herbivore damage in North Americ...

  4. Summer Research of Factors Influencing High School Student’s Choice of Careers in Defense Related Engineering.

    DTIC Science & Technology

    1979-05-01

    Amer. Ind. Hicks, Dwain P.O. Box 951 Tularosa, NM 88352 Tularosa Other Jaramillo , Elaine 1611 Delgado Bpln. NM 17nO ? u4.... -I a. ,~. ,- u Figure II...it Is" Electronics C. Group Pictures In Engineering Ruben Cervantes 10:45 D. Campus Tour Tim Leonard E. Parking Info. Dr. a n FEC 203 Mary Ellen

  5. Extending Regional Seismic Travel Time (RSTT) Tomography to New Regions

    DTIC Science & Technology

    2011-09-01

    Seism . Soc. Am. 59, 1365–1398. Flanagan, M. P., D. A. Dodge, and S. C. Myers (2008). GT merge process: Version 2.0, LLNL technical report, LLNL-TR...Validation of regional and teleseismic travel-time models by relocating ground-truth events, Bull. Seism . Soc. Amer. 94: 897–919. Zhao, L.-S. (1993

  6. Archaeological Investigations at Site 45-OK-11, Chief Joseph Dam Project, Washington.

    DTIC Science & Technology

    1984-01-01

    dentition (Krantz 1959). Urss amer[canus (black bear), arctos (grizzly bear) -- 5 elements. Both species of bear are native to Washington state, Black... dentition associated with age in pronghorn antelope. Journal of Wildlife Management 26(1):1-18. Dunnell, R.C. 1971 Systematics in prehistory. Free Press, New

  7. Notice of release of sugarcane variety HoCP 04-838

    USDA-ARS?s Scientific Manuscript database

    The release of high-yielding varieties to growers is important to the sustainability of all commodity industries. To that end, the Agricultural Research Service of the United States Department of Agriculture, the Louisiana Agricultural Experiment Station of the LSU Agricultural Center, and the Amer...

  8. Notice of release of sugarcane variety Ho 05-961

    USDA-ARS?s Scientific Manuscript database

    The release of high-yielding varieties to growers is important to the sustainability of all commodity industries. To that end, the Agricultural Research Service of the United States Department of Agriculture, the Louisiana Agricultural Experiment Station of the LSU Agricultural Center, and the Amer...

  9. Grazing moderates increases in C3 grass abundance over seven decades across a soil texture gradient in shortgrass steppe

    USDA-ARS?s Scientific Manuscript database

    Questions: How does long-term grazing exclusion influence plant community composition in a semiarid grassland? Can spatial variation in the effects of grazing exclusion be explained by variation in soil texture? Location: The shortgrass steppe of northeastern Colorado, USA, located in the North Amer...

  10. Education through Art after the Second World War: A Critical Review of Art Education in South Korea

    ERIC Educational Resources Information Center

    Kim, Hyungsook

    2014-01-01

    This article examines how progressive education was introduced to South Korea after the Second World War and takes a closer look at critical studies of this history. It argues that the America-led progressive education policies, which focused on art education, were an uncritical adaptation of the superpower's educational ideology and did not…

  11. Multi-year evaluation of mating disruption treatments against gypsy moth

    Treesearch

    Patrick C. Tobin; Kevin W. Thorpe; Laura M. Blackburn

    2007-01-01

    Mating disruption is the use of synthetic pheromone flakes that are aerially applied to foliage with the goal of interfering with male gypsy moths? ability to locate females and mate. Mating disruption is the primary tactic against gypsy moth used in the Gypsy Moth Slow-the-Spread Project (STS) [Tobin et al. 2004. Amer. Entomol. 50:200].

  12. Highly pathogenic avian influenza virus and generation of novel reassortants, United States, 2014-2015

    USDA-ARS?s Scientific Manuscript database

    Asian highly pathogenic avian influenza A(H5N8) viruses spread into North America in 2014 during autumn bird migration. Complete genome sequencing and phylogenetic analysis of 32 H5 viruses identified novel H5N1, H5N2, and H5N8 viruses that emerged in late 2014 through reassortment with North Americ...

  13. Structure of large-angle grain boundaries in metals and ceramic oxides

    SciTech Connect

    Balluffi, R.W.; Bristowe, P.D.; Brokman, A.

    1982-08-01

    Recent progress in the understanding of grain boundary structure in metals and ceramic oxides is critically reviewed with emphasis on both experimental and theoretical work. The review essentially updates an earlier review presented at the 1979 Fall Meeting: i.e., R.W. Balluffi, P.D. Bristowe and C.P. Sun, J. Amer. Ceram. Soc. 64, 25 (1981).

  14. ESTIMATION OF CRITICAL LOADS OF ACIDITY FOR LAKESIN NORTHEASTERN UNITED STATES AND EASTERN CANADA

    EPA Science Inventory

    The New England Governors and Eastern Canadian Premiers (NEG/ECP) adopted the Acid Rain Action Plan in June 1998, and issued a series of action items to support its work toward a reduction of sulfur dioxide (SO2) and nitrogen oxide (NOx ) emissions in northeastern North Americ...

  15. Near-surface geophysical characterization of Holocene faults conducive to geothermal flow near Pyramid Lake, Nevada

    SciTech Connect

    Dudley, Colton; Dorsey, Alison; Louie, John; Schwering, Paul; Pullammanappallil, Satish

    2016-08-01

    Colton Dudley, Alison Dorsey, Paul Opdyke, Dustin Naphan, Marlon Ramos, John Louie, Paul Schwering, and Satish Pullammanappallil, 2013, Near-surface geophysical characterization of Holocene faults conducive to geothermal flow near Pyramid Lake, Nevada: presented at Amer. Assoc. Petroleum Geologists, Pacific Section Annual Meeting, Monterey, Calif., April 19-25.

  16. DoD-Wide Intelligence Career Development Program. General Intelligence Personnel

    DTIC Science & Technology

    1988-07-01

    Philippines, Thailand, Indonesia , Japan, Burma) FREE WORLD FREE WORLD LATIN AMERICA LAT AMER MIDDLE EAST MID EAST (Cyprus, Greece, Egypt, Iran, Iraq, Lebanon...Japanese. Javanese 4-81 PART 4 LANGUAGE PROFIC. ENCY LEVELS AND CODES (For Speaking, Reading, Oral Comprehension and Writing) Level Code N one

  17. Political-Military Trends in Italy, Greece, and Spain

    DTIC Science & Technology

    2005-12-01

    years, a product of EU policy, and to some extent, political convenience. The Basque country and Catalonia are the leading cases, supported by a...the "War of 1898", as they call the Spanish-American War, and Amer- ica’s rise to global power is linked in Spanish intellectual history with Spain’s

  18. Advances in the Consolidated Storm Prediction for Aviation (CoSPA)

    DTIC Science & Technology

    2010-01-01

    since 2008. The forecast system builds upon technologies of the Corridor Integrated Weather System (CIWS; Evans and Ducot 2006) and the 6-hour forecast...Meteorology, Amer. Meteor. Soc., Portland, Oregon, 132-135. Evans, J. E., and E. R. Ducot , 2006: Corridor Integrated Weather System. Lincoln Laboratory

  19. Use of Visual Techniques in Therapy for Developmental Apraxia of Speech.

    ERIC Educational Resources Information Center

    Shelton, Ivy Skaife; Garves, Mary Mertes

    1985-01-01

    The paper describes the development of Signed Target Phoneme (STP) Therapy, using the hand shapes of the Americal Manual Alphabet to cue phonemes. Adding STP to traditional therapy methods with a five-year-old boy diagnosed as having developmental apraxia of speech revealed a positive relationship between application of STP procedures and a more…

  20. How Errors in Component Reliability Affect System Reliability.

    DTIC Science & Technology

    1987-07-01

    maximal s-t flow > z = 0, one can determine p(X) in 0(1Vjlogjlj) time if G is planar. See Itai and Shiloach (1979). The fastest known algorithm for a...sums of bounded random variables, J. Amer. Statist. Assoc., 58, 13-29. 7. Itai , A. and Shiloach, Y. (1979). Maximum flow in planar networks, SIAM J

  1. Large scale three dimensional P velocity structure beneath the Western U. S, and the lost Farallon plate

    SciTech Connect

    Romanowicz, B.A.

    1980-05-01

    The results of a recent large scale three-dimensional study of P velocity beneath North Americal are analyzed from the point of view of the search for the fossil Farallon plate in the mantle beneath the western edge of the North American continent.

  2. Direct Visual and Radar Methods for the Detection, Quantification, and Prediction of Bird Migration.

    DTIC Science & Technology

    1980-04-30

    Lack 1960b; Nisbet and Drury 1968; Richardson 1971, 1974a); four concern only fall migration (Lack 1963a, Gruys- Casimir 1965, Able 1973, Richardson...llth Wea. Radar Conf., Boston. Amer. Meteor. Soc. pp. 6-9. Griffin, D. R. 1974. Bird migration. NY, Dover Reprints. 180 p. Gruys- Casimir , E. M. 1965. On

  3. Global Journal of Computer Science and Technology. Volume 1.2

    ERIC Educational Resources Information Center

    Dixit, R. K.

    2009-01-01

    Articles in this issue of "Global Journal of Computer Science and Technology" include: (1) Input Data Processing Techniques in Intrusion Detection Systems--Short Review (Suhair H. Amer and John A. Hamilton, Jr.); (2) Semantic Annotation of Stock Photography for CBIR Using MPEG-7 standards (R. Balasubramani and V. Kannan); (3) An Experimental Study…

  4. The Structure of Ta3N5 at 16K by Time-of-Flight Neutron Diffraction

    DTIC Science & Technology

    1991-05-30

    Moureu & Hamblet , 1937) . It is reported to have the pseudobrookite (Fe2TiO5) structure. Although the unit cell was originally given as metrically...Neutron Scattering Center, Los Alamos, NM 87545. Moureu, H. & Hamblet , C. H. (1937) . J. Amer. Chem. Soc. 59, 33-40. Mueller, M. H. (1977) . Scripta

  5. Measurement of the Complex Reflectivity of Submerged Thin Plates at Oblique Incidence Angles Using the Two-Sensor Intensity Technique

    DTIC Science & Technology

    1990-08-01

    was the beginning point for many of the subsequent studies concerning the parametric array. In 1956, Ingard and Pridmore-Brown[14] studied the...London) A211, pp. 564, 1952; A222, pp. 1, 1954. 14. Ingard , K.U. and Pridmore-Brown, D.C., "Scattering of Sound by Sound," J. Acoust. Soc. Amer

  6. China’s Global Activism: Strategy, Drivers, and Tools

    DTIC Science & Technology

    2006-10-01

    touched ground in South Amer- ica. Brazilian President Luiz Inacio Lula da Silva and Argentine President Nestor Kirch- ner both led major business...delegations to China earlier in 2004. Da Silva attended the opening of the Beijing offices of the Brazil- ian state oil firm Petrobras , which signed a

  7. Steps Ahead: Adaptation of physical activity and dietary guidelines for reducing unhealthy weight gain in the Lower Misissippi Delta

    USDA-ARS?s Scientific Manuscript database

    The purpose of our study was to test the effectiveness of adapting the Dietary Guidelines for Americans (2010) (DG), with and without a physical activity (PA) component, in reducing weight gain in the Lower Mississippi Delta region (LMD) of the United States. A sample of 121 White and African-Americ...

  8. Culture Wars: Air Force Culture and Civil-Military Relations

    DTIC Science & Technology

    2013-08-01

    into the civil-military implications of this founda- tional legislation is certainly needed. Another tectonic plate moving slowly beneath our feet is the...service? Lastly, there are tectonic movements in place that could be changing Amer- ican civil-military relations in slow but steady ways. For example

  9. Results of a Deep-Tow Multichannel Survey on the Bermuda Rise

    DTIC Science & Technology

    1988-11-01

    spacing) array are towed at full ocean depths [ Gholson and Fagot, 1983]. The design goal for DTAGS is to obtain high-resolution estimates of the structure...western Bermuda t; -A3 Rise, Geol. Soc. Amer Bull., Part 1, 91, 731-740, 1980. Gholson , N. H. and M. G. Fagot, A deep-towed sound source and hydrophone

  10. Poleline Road Disposal Area Remedial Investigation, Fort Richardson, Alaska. Technical Plan

    DTIC Science & Technology

    1991-08-01

    la- of water produced from the Potomac-Raritan- • rs of relatively low permeability, which may Magothy aquifer system are coming through the act as...Potomac-Raritan- Magothy v’ range anmd *.D, dimensiorletis drawdown, equal to CrT,s/ aquifer system in New Jersey (absrtract). Geo. permf- Q.;Soc. Amer

  11. Notes on the Use of Dempster-Shafer and Fuzzy Reasoning to Fuse Identity Attribute Data

    DTIC Science & Technology

    1992-08-01

    8217)onfsibilitv of the ••J)in(tor aublj.’lhin. nd Marketing , AGPS. inquiries should be directed to the .LVthmm,,er. AiS rr’.. ServA,1.ut GC,’- a £i.:ice, CPO Box...amerer distrihution fli cartier frcquency. (Note the curves are only schematics) .. .................................. 13 2 Emitter parameter

  12. The Development and Application of Advanced Video and Microcomputer- Based Command and Control (C2) Systems

    DTIC Science & Technology

    1982-12-01

    video recorders; microcomputers; spatial data management; shared data microcomputer software design; 6502 Microprocessor; APPLE II M AUSTRAC -T (CaeUE...maintain a key role in supporting the continued development of the technology. In 1979, work began at the Computer Corporation of Amer- ica to

  13. 100 Companies Receiving the Largest Dollar Volume of Prime Contract Awards, Fiscal Year 1993

    DTIC Science & Technology

    1993-01-01

    MOTOROLA INC 205,255 CODEX CORPORATION 22,540 MOTOROLA COMMUNICATIONS & ELEC 51,442 MOTOROLA COMPUTER SYSTEMS INC 170 MOTOROLA GMBH 705 MOTOROLA INC...MAGNAVOX GOVT & INDSTRL ELCTR 190,359 PHILIPS ELECTRONIC INSTRUMENTS 273 PHILIPS ELECTRONICS NORTH AMER 1,890 PHILIPS LIGHTING CO 223 PHILIPS MEDICAL

  14. Transforming Censored Samples and Testing Fit.

    DTIC Science & Technology

    2014-09-26

    independent U(0,1) sample. Any fixed permutation of this independent -1 sample could then be transformed with R . Theoretically this is a valid...Fit Techniques. New York: Marcel Dekker. [2] Dudewicz, R.J. and Van der Meulan, E.C., (1981). Entropy based tests of uniformity. J. Amer. Statist. Assoc

  15. The Effect of Langmuir Circulation and Breaking Waves on Subsurface Turbulence for Realistic Wind and Wave Conditions

    DTIC Science & Technology

    2010-07-21

    deepening, are only consistent with observations if LC effects are included in the model (Fig. 1&2; Kukulka et al., 2009). As in the investigation by Gerbi ...and Collaborators (2007), The coupled boundary layers and air-sea transfer experiment in low winds, Bull. Amer. Meteorol. Soc, 88 (3), 341-356. Gerbi

  16. The Power to Declare War: The Ultimate Check on Presidential Power

    DTIC Science & Technology

    2012-03-07

    Florida and operations in South America to include Peru and Argentina.67 In 1846, President Polk dispatched forces to disputed territory in Texas...Appendix A. Text of Formal Declarations of War Passed by the United States of Amer ica .98 War with Great Britain 1812 (Act of Jun. 18, 1812, ch

  17. Cocaine and Instability in Africa: Lessons from Latin America and the Caribbean (Africa Security Brief, Number 5, July 2010)

    DTIC Science & Technology

    2010-07-01

    originated from South Amer- ica . Its cargo added to the mounting cocaine traffic from Latin America that transships West Africa on AFRICA SECURITY...security. Cocaine traffic has provided a vital financial re- source to insurgency groups as well. Recent reports from Peru indicate that the military

  18. Psychosocial mechanisms linking the social environment to mental health in African Americans

    USDA-ARS?s Scientific Manuscript database

    Resource-poor social environments predict poor health, but the mechanisms and processes linking the social environment to psychological health and well-being remain unclear. This study explored psychosocial mediators of the association between the social environment and mental health in African Amer...

  19. Rotationally Symmetric Operators for Surface Interpolation

    DTIC Science & Technology

    1981-11-01

    Computational Geometry for design and rianufacture , Fills Horwood, Chichester UK, 1979. [111 Gladwell 1. and Wait. R. (eds.). Survey of numerical...an object from a single view," Artificial Intelligence 17 (1981), 409-460. [21] Knuth 1). E. "Mathematical typography ," Bull. Amer. Math. Soc. (new

  20. Spectral Analysis of Sound Propagation in Stratified Fluids.

    DTIC Science & Technology

    1980-04-01

    Kodaira, K., The eigenvalue problem for ordinary differential equations of the second order and Heisenberg’s theory of S- matrices , Amer. J. Math. 71...Transient electromagnetic wave propagation in a r dielectric waveguide, Istituto Nazionale di Alta Matematica , 4 Symposia Mathematica XVIII, 239-277

  1. ESTIMATION OF CRITICAL LOADS OF ACIDITY FOR LAKESIN NORTHEASTERN UNITED STATES AND EASTERN CANADA

    EPA Science Inventory

    The New England Governors and Eastern Canadian Premiers (NEG/ECP) adopted the Acid Rain Action Plan in June 1998, and issued a series of action items to support its work toward a reduction of sulfur dioxide (SO2) and nitrogen oxide (NOx ) emissions in northeastern North Americ...

  2. Sitochroa palealis: a Palearctic pyraustine moth (Pyraloidea: Crambidae) newly introduced to North America

    USDA-ARS?s Scientific Manuscript database

    Sitochroa palealis (Denis & Schiffermüller) is recorded from North America for the first time. Adults were collected in Illinois, Indiana, Michigan and Wisconsin. The capture of larvae and adults in four states over a six-year period is strong evidence that S. palealis is established in North Americ...

  3. Development of a fish assemblage tolerance index for the National Rivers and Streams Assessment

    EPA Science Inventory

    Whittier et al (Trans. Amer. Fish. Soc. 136:254-271) developed an assemblage tolerance index (ATI) for stream fishes in the western US based on quantitative tolerance values developed for individual fish and amphibian species. The ATI is conceptually similar to the Hilsenhoff Bi...

  4. Distributed Estimation using Bayesian Consensus Filtering

    DTIC Science & Technology

    2014-06-06

    performance,” in 48th IEEE Conf. Decision Control, (Shanghai, China), pp. 7036–7042, December 2009. [18] M. H. DeGroot , Probability and Statistics...programming,” Autonomous Robots, vol. 16, pp. 49–79, January 2004. [24] M. H. DeGroot , “Reaching a consensus,” J. Amer. Statistical Assoc., vol. 69

  5. Targets of an invasive species: Oviposition preference and larval performance of Cactoblastis cactorum on 14 North American Opuntioid cacti

    USDA-ARS?s Scientific Manuscript database

    Cactoblastis cactorum (Lepidoptera: Pyralidae), the cactus moth, is a well-known biological control agent for cactus species of the genus Opuntia. The arrival of the moth in Florida and its subsequent spread through the southeastern United States poses a threat to opuntioid diversity in North Americ...

  6. Evaluation of Cross-Correlation Methods on a Massive Scale for Accurate Relocation of Seismic Events

    DTIC Science & Technology

    2005-09-28

    MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) Air Force Research Laboratory AFRLfVSBYE 29 Randolph Road Hanscom AFB, MA 01731...double-difference location: application to the 1999 Xiuyan China, sequence, Bull. Seism. Soc. Amer. 94: 867-879. Schaff, D. P., and P. G. Richards (2004b

  7. The Theory of Planned Behavior as It Predicts Potential Intention to Seek Mental Health Services for Depression among College Students

    ERIC Educational Resources Information Center

    Bohon, Lisa M.; Cotter, Kelly A.; Kravitz, Richard L.; Cello, Philip C.; Fernandez y Garcia, Erik

    2016-01-01

    Background: Between 9.5% and 31.3% of college students suffer from depression ("American college health association national college health assessment II: reference group executive summary spring 2013." "Amer. Coll. Health Assoc." 2013; Eagan K, Stolzenberg EB, Ramirez JJ, Aragon, MC, Suchard, RS, Hurtado S. "The American…

  8. To treat or not to treat: Diminishing effectiveness of emamectin benzoate tree injections in ash trees heavily infested by emerald ash borer

    Treesearch

    Charles E. Flower; Jennifer E. Dalton; Kathleen S. Knight; Marie Brikha; Miquel A. Gonzalez-Meler

    2015-01-01

    Emerald ash borer (EAB), a non-native invasive tree-boring beetle, is the primary agent behind thewidespread mortality of ash trees (Fraxinus spp.) in both natural forests and urban areas of North Amer-ica. While a variety of insecticide options have been adopted for protection against EAB attacks, little hasbeen reported on the success of...

  9. Boundary-Value Problem for Two-Dimensional Fluctuations in Boundary Layers

    DTIC Science & Technology

    1985-07-01

    inviscid analysis by P. Durbin "Distortion of turbulence by a constant-shear layer adjacent to a wall," private communication (1977). (l.2e) 2-D...vortices near a boundary," ~ of the Americ~ p ~ ~ , Volume 20, Number 9 (November 1975). 21. Hultgren, Lennart S. and Gustavsson, L. Hakan, " Algebraic

  10. Development of a fish assemblage tolerance index for the National Rivers and Streams Assessment

    EPA Science Inventory

    Whittier et al (Trans. Amer. Fish. Soc. 136:254-271) developed an assemblage tolerance index (ATI) for stream fishes in the western US based on quantitative tolerance values developed for individual fish and amphibian species. The ATI is conceptually similar to the Hilsenhoff Bi...

  11. Estimating North American background ozone in U.S. surface air with two independent global models: Variability, uncertainties, and recommendations

    EPA Science Inventory

    Accurate estimates for North American background (NAB) ozone (O3) in surface air over the United States are needed for setting and implementing an attainable national O3 standard. These estimates rely on simulations with atmospheric chemistry-transport models that set North Amer...

  12. Education through Art after the Second World War: A Critical Review of Art Education in South Korea

    ERIC Educational Resources Information Center

    Kim, Hyungsook

    2014-01-01

    This article examines how progressive education was introduced to South Korea after the Second World War and takes a closer look at critical studies of this history. It argues that the America-led progressive education policies, which focused on art education, were an uncritical adaptation of the superpower's educational ideology and did not…

  13. Steady Flows Drawn from a Stably Stratified Reservoir.

    DTIC Science & Technology

    1981-03-01

    Orkney, J. C. 1955 Experiments on the flow of water from a reservoir through an open horizontal channel. Part I. The production of a uniform... Houille Blanche 4, 44-55. Huber, D. G. 1960 Irrotational motion of two fluid strata towards a line sink. J. Eng. Mech., Proc. Amer. Soc. Civ. Engrs

  14. A Simple Method to Find out when an Ordinary Differential Equation Is Separable

    ERIC Educational Resources Information Center

    Cid, Jose Angel

    2009-01-01

    We present an alternative method to that of Scott (D. Scott, "When is an ordinary differential equation separable?", "Amer. Math. Monthly" 92 (1985), pp. 422-423) to teach the students how to discover whether a differential equation y[prime] = f(x,y) is separable or not when the nonlinearity f(x, y) is not explicitly factorized. Our approach is…

  15. Molecular Characterization of the Citrus Huanglongbing (HLB) associated bacterium Candidatus Liberibacter

    USDA-ARS?s Scientific Manuscript database

    Candidatus Liberibacter is a a-protobacterium associated with citrus Huanglongbing (HLB), a serious threat to citrus production world-wide. We have developed a modified technique to acquire uncharacterized genomic sequences of Candidatus Liberibacter asiaticus (Las), Ca. L. africanus and Ca. L. amer...

  16. Cold-Induced Changes in Arterial Sensitivity

    DTIC Science & Technology

    1991-05-01

    1981 ;263- 271. 25. Cannon, W.B., A. Querido , S.W. Britton and E.M. Bright. Studies on the conditions of activity in endocrine glands. Amer. J. Physiol...Naval Health Research Center P.O. Box 85122 San Diego , CA 92138-9174 Commander U.S. Army Biomedical Research and Development Laboratory Fort Detrick

  17. 12 CFR 220.119 - Applicability of margin requirements to credit extended to corporation in connection with...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., the statutory definition seems to include the particular transaction. See Roberts v. Eaton (CA 2 1954... purpose may conflict with the literal words. U.S. v. Amer. Trucking Ass'ns, 310 U.S. 534, 543 (1940); 2... indebtedness security and (2) voluntary retirement of an equity security. (h) For the reasons indicated above...

  18. 12 CFR 220.119 - Applicability of margin requirements to credit extended to corporation in connection with...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., the statutory definition seems to include the particular transaction. See Roberts v. Eaton (CA 2 1954... purpose may conflict with the literal words. U.S. v. Amer. Trucking Ass'ns, 310 U.S. 534, 543 (1940); 2... indebtedness security and (2) voluntary retirement of an equity security. (h) For the reasons indicated above...

  19. 12 CFR 220.119 - Applicability of margin requirements to credit extended to corporation in connection with...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... seems to include the particular transaction. See Roberts v. Eaton (CA 2 1954) 212 F. 2d 82, and cases... with the literal words. U.S. v. Amer. Trucking Ass'ns, 310 U.S. 534, 543 (1940); 2 Sutherland... and (2) voluntary retirement of an equity security. (h) For the reasons indicated above, it is the...

  20. 12 CFR 220.119 - Applicability of margin requirements to credit extended to corporation in connection with...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... seems to include the particular transaction. See Roberts v. Eaton (CA 2 1954) 212 F. 2d 82, and cases... with the literal words. U.S. v. Amer. Trucking Ass'ns, 310 U.S. 534, 543 (1940); 2 Sutherland... and (2) voluntary retirement of an equity security. (h) For the reasons indicated above, it is the...

  1. The Mechanism of Blood Function and Production After Injury.

    DTIC Science & Technology

    1980-02-01

    The etiology of the anemia ... a- r ults from protein deficiency is multifactorial and may be due to 5 a lack of micronutrients or inadequate...Anemia associated with protein deficiency . Semi.Hematol. 7(1): 55, 1970. 2. Altman, P.L., Dittmer, D.S., eds.: Biology Data Book. Fed.Amer.Soc. Exp.Biol

  2. Estimating North American background ozone in U.S. surface air with two independent global models: Variability, uncertainties, and recommendations

    EPA Science Inventory

    Accurate estimates for North American background (NAB) ozone (O3) in surface air over the United States are needed for setting and implementing an attainable national O3 standard. These estimates rely on simulations with atmospheric chemistry-transport models that set North Amer...

  3. Eye Movements and Spatial Pattern Vision.

    DTIC Science & Technology

    1985-02-28

    the gross form of Kelly’s grating stabilization data replicates in our lab using a similar eyetracker, different subjects and improved methods. 7.0 2...spatiotemporal threshold surface. J. Opt. Soc. Amer., 69, 1340-1349. Kelly, D. H. (1981) Disappearance of stabilized chromatic gratings. Scince , 214, 1257-12587

  4. Rehabilitation of cheatgrass-infested rangelands: management

    USDA-ARS?s Scientific Manuscript database

    This is the final part of a three part series specifically addressing lessons learned concerning the management of rehabilitated cheatgrass-infested rangelands. Steve Novak and Richard Mack reported in 2003 that they found no evidence of outcrossing in 2,000 cheatgrass seedlings from 60 North Americ...

  5. POLICY OPTIONS TO REVERSE THE DECLINE OF WILD PACIFIC SALMON

    EPA Science Inventory

    The primary goal of the Salmon 2100 Project was to identify practical options that have a high probability of maintaining biologically significant, sustainable populations of wild salmon in the Pacific Northwest and California. Wild salmon recovery efforts in western North Americ...

  6. An Investigation of Atmospheric Dynamics through Their Effects on Mesospheric Optical Emission.

    DTIC Science & Technology

    1987-03-23

    continuous variation in the phase of the response in between (Thome, [1968], Testud & Francois (1971), Klostermeyer (1972 a,b) Porter and Than (1974...Walterscheid, Trans. Amer. Geophys. Union, 66, 97, (1985). 23. Testud , J. and P. Francois, J. Atmos. Terr. Phys. 33, 765, (1971). 24. Thame, G.D., J

  7. U.S. Policy and Latin America in the 1990’s

    DTIC Science & Technology

    1992-01-01

    Century of Crisis and Challenge. 1961-1986. Lincoln: U of Nebraska P, 1988. (F 1418 .U715 1988) McClintock , Michael. American Connection. London: Zed...146 .P65 1987) Stallings, Barbara , and Robert R. Kaufman. Debt and Democracy in Latin Americ. Boulder: Westview, 1989. (HJ 8514.5 .D445 1989

  8. The Theory of Planned Behavior as It Predicts Potential Intention to Seek Mental Health Services for Depression among College Students

    ERIC Educational Resources Information Center

    Bohon, Lisa M.; Cotter, Kelly A.; Kravitz, Richard L.; Cello, Philip C.; Fernandez y Garcia, Erik

    2016-01-01

    Background: Between 9.5% and 31.3% of college students suffer from depression ("American college health association national college health assessment II: reference group executive summary spring 2013." "Amer. Coll. Health Assoc." 2013; Eagan K, Stolzenberg EB, Ramirez JJ, Aragon, MC, Suchard, RS, Hurtado S. "The American…

  9. Novel Semiconductors

    DTIC Science & Technology

    2006-11-30

    low-temperature synthesis method we recently developed, and (ii) the synthesis of defined molecular precursors of bimetallic oxides, thereby...Najarian, J. C. Weaver, and D.E. Morse. 2005. Functionalized gold nanoparticles mimic catalytic activity of a polysiloxane-synthesizing enzyme. Advanced...Biocatalytic synthesis of a nanostructured and crystalline bimetallic perovskite-like barium oxofluorotitanate at low temperature. J. Amer. Chem

  10. Characterization of an EPG waveform library for redbanded stink bug, Piezodorus guildinii (Westwood) (Hemiptera: Pentatomidae), on soybean plants

    USDA-ARS?s Scientific Manuscript database

    Studies were conducted with the redbanded stink bug, Piezodorus guildinii (Westwood), using AC-DC electropenetrography (EPG) to record feeding behaviors on vegetative (stem and leaflet) and reproductive (pod) tissues of soybean, Glycine max (L.). P. guildinii is a major pest of soybean in the Americ...

  11. Processing Waveforms as Trees for Pattern Recognition.

    DTIC Science & Technology

    1986-05-01

    patterns (after Ganong (15]) 5.7 ECG Classification As in the previous example, waveforms were simulated with additive colored gaussian noise. In order to...Principles and Techniques- (AAPG Course Note Series 13), Amer. Assoc. Pet. Geol., Tulsa, OK,p. 86, (1984). [15] W. F. Ganong , Review of Medical Physiology. Lange, Los Altos, CA. pp. 393-408, (1973). /

  12. Laurel wilt: A global threat to avocado production

    USDA-ARS?s Scientific Manuscript database

    Laurel wilt kills members of the Lauraceae plant family, including avocado. The disease has invaded much of the southeastern USA, and threatens avocado commerce and homeowner production in Florida, valuable germplasm in Miami (USDA-ARS), and major production and germplasm in California and MesoAmer...

  13. Colorado Technology Transfer Plan for Economic Development.

    ERIC Educational Resources Information Center

    Colorado Advanced Tech. Inst., Denver.

    Recognizing the importance of technology transfer to economic growth, the U.S. Economic Development Administration (EDA) provided the Colorado Advanced Technology Institute (CATI) with a grant to coordinate the development of a plan for using technology transfer in Colorado's economic development. The plan, outlined in this report, describes the…

  14. [ANIMAL TOXOCARIASIS IN A MEGALOPOLIS: EPIDEMIC ASPECTS].

    PubMed

    Panova, O A; Glamazdin, I G; Spiridonov, S E

    2015-01-01

    The prevalence of toxocariasis was studied among a population of domestic and stray dogs and cats. In a megalopolis, Toxocara invasion was 31.6% in a population of cats and 82 and 25.4% in that of puppies and dogs, respectively. A method was developed for the molecular genetic identification of T. cati and T. canis.

  15. [Ocular toxocariasis in a boy with idiopathic nephrotic syndrome - a case report].

    PubMed

    Antonowicz, Agnieszka; Skrzypczyk, Piotr; Kępa, Beata; Pańczyk-Tomaszewska, Małgorzata

    2016-10-19

    Toxocariasis is a common zoonosis caused by infection with Toxocara canis or cati larvae. Ocular toxocariasis is one of the forms of infestation found in 1/1,000 - 1/10,000 children. Children with idiopathic nephrotic syndrome (INS) are at high risk of infections, also parasitic infestations, which can, in turn, cause relapses of the disease.

  16. Notoedric mange in the Florida panther (Felis concolor coryi).

    PubMed

    Maehr, D S; Greiner, E C; Lanier, J E; Murphy, D

    1995-04-01

    Notoedric mange (Notoedres cati) was found in a neonate Florida panther (Felis concolor coryi) and presumably its mother on 22 June 1992 and 8 February 1993, respectively, in Collier County, Florida (USA). Both infestations were treated successfully with 0.2 mg/kg ivermectin. This is the first known case of notoedric mange in the endangered Florida panther.

  17. Understanding Pedagogical Design Capacity through Teachers' Narratives

    ERIC Educational Resources Information Center

    Davis, Elizabeth A.; Beyer, Carrie; Forbes, Cory T.; Stevens, Shawn

    2011-01-01

    Teachers need to develop the ability to adapt curriculum materials. Two elementary teachers, Maggie and Catie, were asked to write narratives about their use of and changes to particular reform-oriented science lesson plans. Maggie drew on her knowledge of and experiences with students, as well as other knowledge, experiences, and resources, to…

  18. CYANOBACTERIA PASSAGE DURING FILTER PERTURBATION EPISODES

    EPA Science Inventory

    Eight pilot-scale in-line filtration trials were performed to evaluate the passage of cyanobacterial cells through drinking water filters after sudden increases in hydraulic loading rates. Trials were performed at 30 C using two coagulant combinations (aluminum sulfate and cati...

  19. Zoonotic parasites of bobcats around human landscapes.

    PubMed

    Carver, Scott; Scorza, Andrea V; Bevins, Sarah N; Riley, Seth P D; Crooks, Kevin R; Vandewoude, Sue; Lappin, Michael R

    2012-09-01

    We analyzed Lynx rufus fecal parasites from California and Colorado, hypothesizing that bobcats shed zoonotic parasites around human landscapes. Giardia duodenalis, Cryptosporidium, Ancylostoma, Uncinaria, and Toxocara cati were shed. Toxoplasma gondii serology demonstrated exposure. Giardia and Cryptosporidium shedding increased near large human populations. Genotyped Giardia may indicate indirect transmission with humans.

  20. Coding Major Fields of Study.

    ERIC Educational Resources Information Center

    Bobbitt, L. G.; Carroll, C. D.

    The National Center for Education Statistics conducts surveys which require the coding of the respondent's major field of study. This paper presents a new system for the coding of major field of study. It operates on-line i a Computer Assisted Telephone Interview (CATI) environment and allows conversational checks to verify coding directly from…

  1. BENZO[A]PYRENE-7,8-QUINONE FORMS COVALENT-DNA ADDUCTS IN VITRO BUT NONE WERE DETECTED IN THE LUNGS OR LIVERS OF STRAIN A/J MICE IN VIVO

    EPA Science Inventory

    Benzo[a]pyrene (B[a]P) is a potent human and rodent lung carcinogen. This activity has been ascribed in part to the formation of B[a]P-7,8-dio1-9,10-epoxide (BPDE)-DNA adducts. Other carcinogenic mechanisms have been proposed: 1.] The induction of apurinic sites from radical cati...

  2. 77 FR 24684 - Proposed Information Collection; Comment Request; 2013-2015 American Community Survey Methods...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... conduct Computer-Assisted Telephone Interviews (CATI) or Computer-Assisted Personal Interviews (CAPI... Computer Audio Recorded Interviewing (CARI) technology to record portions of the interview related to the questions being tested for use in behavior coding. There will also be a Content Follow-up reinterview as...

  3. 78 FR 22511 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ... Community Survey. OMB Control Number: 0607-0810. Form Number(s): ACS-1, ACS-1(SP), ACS-1PR, ACS-1PR(SP), ACS CATI(HU), ACS CAPI(HU), ACS Internet (HU), ACS-1(GQ), ACS-1(GQ)(PR). Type of Request: Revision of a... Community Survey (ACS). The Census Bureau has developed a methodology to collect and update...

  4. 77 FR 53171 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... Community Survey Methods Panel Tests. OMB Control Number: 0607-0936 Form Number(s): ACS-1, ACS-1(SP), ACS-1PR, ACS-1PR(SP), ACS CATI(HU), ACS CAPI(HU), ACS (Internet). Type of Request: Revision of a currently... Budget (OMB) to conduct the American Community Survey (ACS) Methods Panel tests. The ACS...

  5. In Situ Clay Formation: Evaluation of a Proposed New Technology for Stable Containment Barriers

    DTIC Science & Technology

    2004-03-01

    Albuquerque, New Mexico 87185 and Livermore, California 94550 Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company...precipitaci6n homogenea. Parte11. Empleo de resinas cati6nicas en fase H+. Estud. Geol. Madrid 30, 281-287. Linares J. and F. Huertas (1971a) Kaolinite

  6. A Study of the Application of the Lognormal and Gamma Distributions to Corrective Maintenance Repair Time Data.

    DTIC Science & Technology

    1982-10-01

    assistance and patince; Professor D. P. Gaver as the second reader; the members of the Electricite de France , Rome Air Development Center and United Kingdom...P -98 F Artils Insi2c 4 ion Reoort. Volume JI qal y *bng, TRW Systems Group, May 16, 1978. 18. Private Communi-cati4on from J. Dore, Electricite

  7. Root-selective expression of "AtCAX4" and "AtCAX2" results in reduced lamina cadmium in field-grown "Nicotiana tabacum L"

    USDA-ARS?s Scientific Manuscript database

    To assess the impact of enhanced root vacuole cadmium (Cd) sequestration on leaf Cd accumulation under a low Cd dose, as generally occurs in agriculture, leaf Cd accumulation was examined in field-grown tobacco plants expressing genes encoding the high-capacity-Cd, tonoplast-localized, divalent cati...

  8. Establishing a 1991 Veterans Research Network to Improve Characterization of Gulf War Illness and Provide a National Resource for Veterans and Investigators

    DTIC Science & Technology

    2015-09-01

    a multifaceted survey research strategy to obtain current information on symptoms and medical conditions from a nationally representative sample of...epidemiology, survey research, case definition, research network 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES...the-art survey research strategy. This includes a Computer-Assisted Telephone Interview (CATI) survey of a nationally representative sample of

  9. [Scabies among the Zoo mammals].

    PubMed

    Zuchowska, E

    1991-01-01

    Scabies was observed in 9 species of mammals at the Zoological Garden of Lódź in years 1957-1989. Sarcoptes scabiei spp. was found in capybaras, tapirs and camelids. Notoedres cati was recorded from the siberian tiger, but Notoedres sp. from the Erinaceus europaeus. Scabies was also found in a wild dead Tapla europaea at the Zoo area.

  10. The People United Shall Never Be Divided: Reflections on Community, Collaboration, and Change

    ERIC Educational Resources Information Center

    de los Rios, Cati V.; Ochoa, Gilda L.

    2012-01-01

    Mounted on the walls, windows, and bookcases of Ms. Cati de los Rios's Pomona High School classroom are a multitude of faces, mainly heroes, martyrs, and leaders of Latina/o and African descent. These faces are a symbol of the countercultural and student-centered approach to education that occurs in her classroom. The mere presence of these…

  11. BENZO[A]PYRENE-7,8-QUINONE FORMS COVALENT-DNA ADDUCTS IN VITRO BUT NONE WERE DETECTED IN THE LUNGS OR LIVERS OF STRAIN A/J MICE IN VIVO

    EPA Science Inventory

    Benzo[a]pyrene (B[a]P) is a potent human and rodent lung carcinogen. This activity has been ascribed in part to the formation of B[a]P-7,8-dio1-9,10-epoxide (BPDE)-DNA adducts. Other carcinogenic mechanisms have been proposed: 1.] The induction of apurinic sites from radical cati...

  12. US EPA, Pesticide Product Label, (CHLORINATING ...

    EPA Pesticide Factsheets

    2011-04-21

    ... ''III .. ." fI.\\4 411111' •• '' l""v,AO""MINTAL HA'A.DII 'fI', ... UC'II.III •• k to ",".11 ••• .. Of '._ft. "f •• "', Of "" ... T'''JeII .'flweft' CatI"., M IIIKI'I" ... '1'1'0 '._ft. ...

  13. The People United Shall Never Be Divided: Reflections on Community, Collaboration, and Change

    ERIC Educational Resources Information Center

    de los Rios, Cati V.; Ochoa, Gilda L.

    2012-01-01

    Mounted on the walls, windows, and bookcases of Ms. Cati de los Rios's Pomona High School classroom are a multitude of faces, mainly heroes, martyrs, and leaders of Latina/o and African descent. These faces are a symbol of the countercultural and student-centered approach to education that occurs in her classroom. The mere presence of these…

  14. Cultural Capital and Transnational Parenting: The Case of Ghanaian Migrants in the United States

    ERIC Educational Resources Information Center

    Coe, Cati; Shani, Serah

    2015-01-01

    What does cultural capital mean in a transnational context? In this article, Cati Coe and Serah Shani illustrate through the case of Ghanaian immigrants to the United States that the concept of cultural capital offers many insights into immigrants' parenting strategies, but that it also needs to be refined in several ways to account for the…

  15. Sequence variation in mitochondrial cox1 and nad1 genes of ascaridoid nematodes in cats and dogs from Iran.

    PubMed

    Mikaeili, F; Mirhendi, H; Mohebali, M; Hosseini, M; Sharbatkhori, M; Zarei, Z; Kia, E B

    2015-07-01

    The study was conducted to determine the sequence variation in two mitochondrial genes, namely cytochrome c oxidase 1 (pcox1) and NADH dehydrogenase 1 (pnad1) within and among isolates of Toxocara cati, Toxocara canis and Toxascaris leonina. Genomic DNA was extracted from 32 isolates of T. cati, 9 isolates of T. canis and 19 isolates of T. leonina collected from cats and dogs in different geographical areas of Iran. Mitochondrial genes were amplified by polymerase chain reaction (PCR) and sequenced. Sequence data were aligned using the BioEdit software and compared with published sequences in GenBank. Phylogenetic analysis was performed using Bayesian inference and maximum likelihood methods. Based on pairwise comparison, intra-species genetic diversity within Iranian isolates of T. cati, T. canis and T. leonina amounted to 0-2.3%, 0-1.3% and 0-1.0% for pcox1 and 0-2.0%, 0-1.7% and 0-2.6% for pnad1, respectively. Inter-species sequence variation among the three ascaridoid nematodes was significantly higher, being 9.5-16.6% for pcox1 and 11.9-26.7% for pnad1. Sequence and phylogenetic analysis of the pcox1 and pnad1 genes indicated that there is significant genetic diversity within and among isolates of T. cati, T. canis and T. leonina from different areas of Iran, and these genes can be used for studying genetic variation of ascaridoid nematodes.

  16. Zoonotic Parasites of Bobcats around Human Landscapes

    PubMed Central

    Scorza, Andrea V.; Bevins, Sarah N.; Riley, Seth P. D.; Crooks, Kevin R.; VandeWoude, Sue; Lappin, Michael R.

    2012-01-01

    We analyzed Lynx rufus fecal parasites from California and Colorado, hypothesizing that bobcats shed zoonotic parasites around human landscapes. Giardia duodenalis, Cryptosporidium, Ancylostoma, Uncinaria, and Toxocara cati were shed. Toxoplasma gondii serology demonstrated exposure. Giardia and Cryptosporidium shedding increased near large human populations. Genotyped Giardia may indicate indirect transmission with humans. PMID:22718941

  17. 77 FR 11545 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... reinforce the importance of timely collection of data related to tobacco usage. The evolution of new... universe for this study is English-speaking U.S. residents aged 18-65. The sample frame will consist of a... complete an initial CATI survey consisting of a short series of simple demographic questions, general...

  18. 77 FR 35404 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... evaluation of public health programs. The evolution of completely new, completely mobile communications... 18- 65. The sample frame will consist of a national random digit dial sample of telephone numbers... complete an initial CATI survey consisting of a short series of simple demographic questions, general...

  19. Theoretical study of model compound I complexes of horseradish peroxidase and catalase.

    PubMed Central

    Du, P; Loew, G H

    1995-01-01

    Theoretical studies of the electronic structure and spectra of models for the ferric resting state and Compound I intermediates of horseradish peroxidase (HRP-I) and catalase (CAT-I) have been performed using the INDO-RHF/CI method. The goals of these studies were twofold: i) to determine whether the axial ligand of HRP is best described as imidazole or imidazolate, and ii) to address the long-standing question of whether HRP-I and CAT-I are a1u and a2u tau cation radicals. Only the imidazolate HRP-I model led to a calculated electronic spectra consistent with the experimentally observed significant reduction in the intensity of the Soret band compared with the ferric resting state. These results provide compelling evidence for significant proton transfer to the conserved Asp residue by the proximal histidine. The origin of the observed reduction of the Soret band intensity in HRP-I and CAT-I spectra has been examined and found to be caused by the mixing of charge transfer transitions into the predominantly porphyrin tau-tau transitions. For both HRP-I and CAT-I, the a1u porphyrin tau cation state is the lowest energy, and it is further stabilized by both the anionic form of the ligand and the porphyrin ring substituents of protoporphyrin-IX. The calculated values of quadrupole-splitting observed in the Mossbauer resonance of HRP-I and CAT-I are similar for the a1u and a2u tau cation radicals. Electronic spectrum of the a1u tau cation radical of HRP-I are more similar to the observed spectra, whereas the spectra of both a1u tau and a2u tau cation radicals of CAT-I resemble the observed spectra. These results also indicate the limitations of using any one observable property to try to distinguish between these states. Taken together, comparison of calculated and observed properties indicate that there is no compelling reason to invoke the higher energy a2u tau cation radical as the favored state in HRP-I and CAT-I. Both ground-state properties and electronic spectra

  20. Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl Coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils.

    PubMed

    González-Mañán, Daniel; Tapia, Gladys; Gormaz, Juan Guillermo; D'Espessailles, Amanda; Espinosa, Alejandra; Masson, Lilia; Varela, Patricia; Valenzuela, Alfonso; Valenzuela, Rodrigo

    2012-07-01

    High dietary intake of n-6 fatty acids in relation to n-3 fatty acids may generate health disorders, such as cardiovascular and other chronic diseases. Fish consumption rich in n-3 fatty acids is low in Latin America, it being necessary to seek other alternatives to provide α-linolenic acid (ALA), precursor of n-3 LCPUFA (EPA and DHA). Two innovative oils were assayed, chia (Salvia hispanica) and rosa mosqueta (Rosa rubiginosa). This study evaluated hepatic bioconversion of ALA to EPA and DHA, expression of PPAR-α, acyl-Coenzyme A oxidase 1 (ACOX1) and carnitine acyltransferase I (CAT-I), and accumulation of EPA and DHA in plasma and adipose tissue in Sprague-Dawley rats. Three experimental groups were fed 21 days: sunflower oil (SFO, control); chia oil (CO); rosa mosqueta oil (RMO). Fatty acid composition of total lipids and phospholipids from plasma, hepatic and adipose tissue was assessed by gas-liquid chromatography and TLC. Expression of PPAR-α (RT-PCR) and ACOX1 and CAT-I (Western blot). CO and RMO increased plasma, hepatic and adipose tissue levels of ALA, EPA and DHA and decreased n-6:n-3 ratio compared to SFO (p < 0.05, One-way ANOVA and Newman-Keuls test). CO increased levels of ALA and EPA compared to RMO (p < 0.05). No significant differences were observed for DHA levels. CO also increased the expression of PPAR-α, ACOX1 and CAT-I. Only CAT-I levels were increased by RO. CO and RMO may be a nutritional alternative to provide ALA for its bioconversion to EPA and DHA, and to increase the expression of PPAR-α, ACOX1 and CAT-I, especially CO-oil.

  1. JPRS Report China

    DTIC Science & Technology

    2007-11-02

    cab- inet adopted the following central policies: 1. Increase the openness of politics and reduce corrup- tion and its root causes. This measure ...opinion world- wide. The measures the Chinese Government took to put down the rebellion were entirely consistent with interna- tionally recognized... early 1980’s, it is quite difficult to bring about a peaceful solution to the conflicts in the Central Amer- ican region. Another opinion holds that

  2. JPRS Report Near East & South Asia, India.

    DTIC Science & Technology

    1993-06-24

    government in that enslavened portion of Kashmir has propagandized against India to its people. Since 1991 , Occupied Kashmir has made it its mission...when some object of hatred—in the case mentioned. Israel—was hit by some one—by Sadat for a few days in 1973, by Saddam for fewer still in 1991 —it...the Gulf Crisis, James Piscatori, editor. The Amer- ican Academy of Arts and Sciences, 1991 , provides many glimpses of the diverse responses of

  3. Runoff Prediction Uncertainty for Ungauged Agricultural Watersheds

    DTIC Science & Technology

    1990-12-01

    Saxton , K . E . (1981). "Soil water charac- teristics." Amer. Soc. Agric. Engrg. Paper No. 81-2510. Rawls , W . J ., Brakensiek, D. L., and... Saxton , K . E . (1982). "Estimation of soil water properties." Trans. ASAE, 25(5), 1316-1320, 1328. Rawls , W . J ., Brakensiek, D. L., and Soni, B. (1983...theory in hydrologic prac- tice, CEP8O-81HJM2, Engrg. Res. Ctr., HYDROWAR program, Colorado State Univ., Fort Collins, Colo. Rawls , W

  4. Investigations of Eurasian Seismic Sources and Upper Mantle Structure.

    DTIC Science & Technology

    1987-03-06

    from seismology, however. From a synthesis of thermobarometric data on kimberlite xenoliths, Boyd and Gurney [ 1986] argue that systematic, nearly...Inclusions in Kimberlites and Other Volcanics, edited by F.R. Boyd and H.O.A. Meyer, Amer. Geophys. Union, Washington, D.C., 1-14, 1979. 51 Jordan...O’Hara, 1975; Boyd and McCallister, 1976; Green and Liebermann, 1976]. Peridotite nodules from kimberlite pipes in cratonic areas are observed to

  5. A Survey of Probabilistic Methods for Dynamical Systems with Uncertain Parameters.

    DTIC Science & Technology

    1986-05-01

    J., "An Approach to the Theoretical Background of Statistical Energy Analysis Applied to Structural Vibration," Journ. Acoust. Soc. Amer., Vol. 69...1973, Sect. 8.3. 80. Lyon, R.H., " Statistical Energy Analysis of Dynamical Systems," M.I.T. Press, 1975. e) Late References added in Proofreading !! 81...Dowell, E.H., and Kubota, Y., "Asymptotic Modal Analysis and ’~ y C-" -165- Statistical Energy Analysis of Dynamical Systems," Journ. Appi. - Mech

  6. Chemical Tumor Promoters, Oncogenes and Growth Factors: Modulators of Gap Junctional Intercellular Communication

    DTIC Science & Technology

    1991-01-01

    Bennett and D.C. Spray, Cold Spring Harbor Laboratory, Cold Spring Harbor , NY, 1985, p. 289. 5. Madhukar, B.V., J.E. Trosko and C.C. Chang. in Cell...P.D. Hoerger. Cold Spring Harbor Labo- ratory, Cold Spring Harbor , N.Y., 1988. p. 139. 42. Lacey, S.W.. Amer. 1. Med. Sci. 29:39 (1986). 43

  7. Rising Dragon: Infrastructure Development and Chinese Influence in Vietnam

    DTIC Science & Technology

    2009-06-01

    Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and...and Aspiration," Contemporary Southeast Asia 27, no. 1 (April, 2005), 102–122. 5 Ralf Emmers , Maritime Disputes in the South China Sea: Strategic and...Press, 1999), 68–129.; Ramses Amer, "Assessing Sino-Vietnamese Relations through the Management of Contentious Issues," Contemporary Southeast Asia

  8. A Converse of the Mean Value Theorem Made Easy

    ERIC Educational Resources Information Center

    Mortici, Cristinel

    2011-01-01

    The aim of this article is to discuss some results about the converse mean value theorem stated by Tong and Braza [J. Tong and P. Braza, "A converse of the mean value theorem", Amer. Math. Monthly 104(10), (1997), pp. 939-942] and Almeida [R. Almeida, "An elementary proof of a converse mean-value theorem", Internat. J. Math. Ed. Sci. Tech. 39(8)…

  9. MR Imaging Based Treatment Planning for Radiotherapy of Prostate Cancer

    DTIC Science & Technology

    2007-02-01

    image- guided stereotactic localization in the hypofractionated treatment of lung cancer. Int. J. Rad. Oncol. Bio. Phys. 66: 738-747, 2006. Chapters...L, Ma C. Benefit of 3D image-guided stereotactic localization in the hypofractionated treatment of lung cancer. Proc. Medical Physics, 33(6), 1993...9. Amer AM, Mott J, Mackay RI, et al. Prediction of the benefits from dose-escalated hypofractionated intensity-modulated radiotherapy for

  10. Targeting Breast Cancer Vasculature

    DTIC Science & Technology

    2006-03-01

    Marra, M.A., Prange, C., Morin, P.J., Polyak , K., et al. (1999). A publicAmer, M.H. (1982). Chemotherapy and pattern of metastases in breast can...8217n8 Ftts tm. 492, 7177 3 Abdel-Ghant M. ?l dl. (1993) Trun@ted dip+lidyi peptidaa lv is a prteni dti-adhesion md anti-mebslasis pcptide for rat hread

  11. Hormonal Interference with Pheromone Systems in Parasitic Acarines, Especially Ixodid Ticks.

    DTIC Science & Technology

    1982-05-01

    1980. Sex pheromone gland of the Gypsy Moth Parasitoid, Apanteles melanoscelus. Revaluation and ultrastructural Survey. Ann. Entomol. Soc. Amer. 73...the noctuid moth Trichoplusia ni (Hubner), the sex pheromone gland is an eversible sac of glandular epi- thelium composed of tall columnar cells filled...pheromone is thought to pass, since no secretory ducts were found. In the red-banded leaf roller moth Argyro- taenia velutinana (Walker), the sex pheromone

  12. Effects of Mountain Ranges on Mesoscale Systems Development.

    DTIC Science & Technology

    1985-09-01

    and July should be suiiall; insolation is more intense in June, but ambient air (and soil) temperatures are warmer in July. In Figs. 1-24, convection...merging of these lines, making the case appear similar in many respects to the " derecho " as described by Johns and Hirt (1983). We note qualitatively... derecho ...A severe weather producing convective system. Preprints. 13th Conf. Severe Local Storms, Amer. Meteor. Soo., 17-20 October, Tulsa, Oklahoma

  13. A Finite Difference Approximation for a Coupled System of Nonlinear Size-Structured Populations

    DTIC Science & Technology

    2000-01-01

    are available. For a classical Lotka - Volterra competition model which is represented by a system of N di erential equations, conditions on the growth...Methods Appl. Sci., 9 (1999), 1379-1391. [5] S. Ahmed, Extinction of Species in Nonautonomous Lotka - Volterra Systems, Proc. Amer. Math. Soc., 127 (1999...Walter DeGruyter, Berlin, 1995. [7] S. Ahmed and F. Montes de Oca, Extinction in Nonautonomous T -periodic Lotka - Volterra System, Appl. Math. Comput

  14. Modeling and Evaluating the Environmental Degradation of UHTCs under Hypersonic Flow (Preprint)

    DTIC Science & Technology

    2014-02-01

    34Oxidation behavior of zirconium diboride silicon carbide produced by the spark plasma sintering method," J Amer. Ceram. Soc., 92 [9] 2046-2052...vehicles. It uses a plasma generated gas mixture which contains a high fraction of ionized atoms of oxygen and nitrogen. Recombination of the charged...species is catalyzed by the sample surface to release heat. The plasma is accelerated to high velocities (supersonic but not hypersonic) using an

  15. Probability and Statistics and Applications

    DTIC Science & Technology

    1977-07-01

    now being prepared as a technical report. 3. Other Research and Other Activities The paper by Glcscr and Kunte (1976), which was revised under the...of Variationl. J. Amer. Statist. Assoc. 71, 977-981. [20] Gleser, Leon Jay and Kunte , Sudhakar (1976). On Asymptotically Optimal Sequential Bayes...and Asymptotically Pointwise Optimal Stopping Rules. (Parts of this report were published in Gleser and Kunte (1976)). 364. Wolfson, D. B. Limit

  16. Depth Discrimination as a Function of Target and Background Chromatic Composition.

    DTIC Science & Technology

    1980-01-01

    E 1473 ITooN OF Nov e is OnsOLTE’ UNCLASSIFIED $ N 0102- LF- 01- 6601 SCURITY CLASIFICATION OF TWIS PAGE (Wh n Dee Slmio0e) SECURITY CLASSIFICArION OF...Westheimer. Factors involving accommodation responses of the human eye. J. opt. Soc. Amer., 1959, 49, 568-571 19 r I.f 1 -19- D I S T R I B U T IO N

  17. Extensions of a Theory of Networks and Learning: Outliers and Negative Examples

    DTIC Science & Technology

    1990-07-01

    Tikhonov and V. Y. Arsenin . Solutions of 11l- posed Problems . W. H. Winston, Washington, D.C., 1977 . [15] A. Verri and...regularization approach ( Tikhonov , 1963; Tikhonov and Arsenin , 1977 ; Morozov, 1984; Bertero, 1986) selects the function f that solves the variational problem of...8] J. L. Marroquin, S. Mitter, and T. Poggio. Probabilistic solution of ill - posed problems in computational vision. J. Amer. Stat. Assoc.,

  18. Robust Computation of Linear Models, or How to Find a Needle in a Haystack

    DTIC Science & Technology

    2012-02-17

    involve Monte Carlo simulation, nonlinear programming, etc. because the success of these approaches depends largely on parameter settings and providence...components: Primary theory and Monte Carlo . J. Amer. Statist. Assoc., 80(391):759–766, 1985. [Led01] M. Ledoux. The Concentration of Measure Phenomenon...Auton, A. Indap, K. S. King, S. Bergmann, M.R. Nelson, M. Stephens, and C. D. Bustamante . Genes mirror geography within Europe. Nature, 456(7218):98–101

  19. Second Colloquim on the Scattering of Ultrasonic Waves (Deuxieme Colloque sur la Diffusion des Ondes Ultrasonores).

    DTIC Science & Technology

    1985-01-29

    elastic plate imbedded in that fluid, is capable of exciting elastic Rayleigh and Lamb -type waves [21 in the plate . Such...resonances,’ fluid layers; elastic plates ; elastic targets; cavities; inclusions; surface waves ,’ helical waves ,’ resonance scattering theory," inhomo...and H. Uberall, Resonance theory of acoustic waves interacting with an elastic plate , J. Acoust. Soc. Amer., Vol. 66, p.1857-1866, 1979.

  20. Chemically Modified Electrodes. Part XX. Radiofrequency Plasma Polymerization of Vinylferrocene on Glassy Carbon and Platinum Electrodes.

    DTIC Science & Technology

    1980-01-29

    1978) 3222. 3 N. Oyama and F. C. Anson , J. Amer. Chem. Soc., 101 (1979) 739. 4 Symposium on Chemically Modified Electrodes, Extended Abstracts of...T. Hirotsu, J. Polym. Sci., Polym. Chem. Ed., 16 (1978) 229. 24 N. Oyama, A. P. Brown and F. C. Anson , J. Electroanal. Chem., 87 (1978) 435. 25 H...91232 Dr. Fred Saalfeld Mr. John Boyle Chemistry Division Materials Branch Naval Research Laboratory Naval Ship Engineering Center Washington, D.C

  1. Optimization of Lightning Warning Areas at Cape Canaveral/Kennedy Space Center

    DTIC Science & Technology

    2013-06-01

    Cumulus, to showers , to even thunderstorms in extreme events. In addition, while the thunderstorm enhancing vertical motion at the sea breeze front...Detection Network: post-upgrade status. Extended Abstracts, Second Conf. on the Meteorological Applications of Lightning Data, Atlanta, GA, Amer. Meteor ...duration in the continental United States: 1989-96. J. Appl. Meteor . 38, 1013–1019. Kirkwood, C. W., 1997: Strategic Decision Making. Wadsworth

  2. The Effects of a Remote Atoll and Lagoon on the Marine Boundary Layer

    DTIC Science & Technology

    2012-12-01

    showers . There is a dryer season from June through September that also sees slightly cooler temperatures. The most rain falls during the December...island of Phoenix, Arizona, J. Clim. Appl. Meteor ., 26, 712-716. Chambers, C. and T. Li, 2011: The effect of Hawaii’s big island on track and...structure of tropical cyclones passing to the south and west, Amer. Meteor . Soc., 139, 3609- 3627. Changnon, S. (Ed.), 1981: METROMEX: A Review and

  3. A Climatology of Mesoscale Wave Disturbances Seen in Mesonet Data During Storm-Fest

    DTIC Science & Technology

    2011-07-21

    that these values were influenced by the convection. (Moderate referring to convection greater in intensity than simple showers yet not to the degree...gravity waves: Results from two-dimensional numerical experiments. Quart. J. Meteor . Soc., 112, 899-925. Clarke, R. H., R. K. Smith, and D. G. Reid, 1981...Gould, and G. Granger, 1994: Zeb: Software for integration, display, and management of diverse environmental datasets. Bull. Amer. Meteor . Soc., 75, 783

  4. Optimization and Statistical Evaluation of GOES Cloud-Top Properties for Nowcasting Lightning Initiation

    DTIC Science & Technology

    2010-03-01

    work with. I sincerely appreciate their help and friendship. Finally, my family deserves a shower of gratitude for putting up with the countless...determined from satellite data. J. Appl. Meteor ., 18, 502–517. Byers, H.R., and R.R. Braham, 1948: Thunderstorm structure and circulation. J. Atmos. Sci...5, 71–86. Changnon, S. A., 2001: Thunderstorm rainfall in the conterminous United States. Bull. Amer. Meteor . Soc., 82, 1925-1940. ———— , 2003

  5. An Assessment of the Meteorological Conditions Leading to the NOAA WP-3D Engine Compressor Stalls of February 9, 2007, Due to Sea Salt Aerosol Particle Fouling

    DTIC Science & Technology

    2007-10-25

    brief rain shower . After reaching a minimum altitude of 275 m the engine was restarted and N42RF began a slow climb. Eventually engines #3 and #4...much engine efficiency was regained by the brief flight period in the rain shower while the engines were being restarted. Engineers further cautioned...Transfer Experiment, Bull. Amer. Meteor . Soc. 88, 357-374. Blanchard, D. C., A. H. Woodcock, and R. J. Cipriano (1984), The vertical distribution of

  6. The Impacts of Global Scale Climate Variations on Southwest Asia

    DTIC Science & Technology

    2006-03-01

    very sparse, and often falls in the form of convective showers , which often are difficult to predict. We split the six-month period of...solutions for heat induced tropical circulation. Quart. J. Roy. Meteor . Soc., 106, 447-462. Halpert, M. S., and C. F. Ropelewski, 1992: Surface...Coauthors, 1996: The NCEP/NCAR 40-year reanalysis project. Bull. Amer. Meteor . Soc. 77, 437-471. Kiladis, G. N. and H. F. Diaz, 1989: Global

  7. Normal coderivative for multifunctions and implicit function theorems

    NASA Astrophysics Data System (ADS)

    Lee, G. M.; Tam, N. N.; Yen, N. D.

    2008-02-01

    In the framework of the theory of normal coderivative for multifunctions, new implicit function theorems are obtained. The main tools of the proofs are the Ekeland variational principle, a nonsmooth version of Fermat's rule, a sum rule, and the differential estimate for marginal functions established by B.S. Mordukhovich and Y. Shao [B.S. Mordukhovich, Y. Shao, Nonsmooth sequential analysis in Asplund spaces, Trans. Amer. Math. Soc. 348 (1996) 1235-1280].

  8. Laboratory Validation of the Sand Fly Fever Virus Antigen Assay

    DTIC Science & Technology

    2015-12-01

    STATEMENT A. Approved for public release. 13. SUPPLEMENTARY NOTES Cleared, 88PA, Case # 2015-2928. J of Amer. Mosquito Control Assoc., 31(4):380–383...Arumowot virus, are transmitted by mosquitoes (Tesh 1988). The most clinically significant members of the SF virus group are RVFV, Toscana virus... mosquitoes , and RVFV can cause serious hemorrhagic disease or high fever in humans (Tomori and Fabiyi 1976, Tesh 1988); RVFV is of particular military

  9. Environmental Assessment During Intelligence Preparation of the Battlefield (IPB) - Evaluation of the TIC-Master Computer Program

    DTIC Science & Technology

    2012-04-01

    325412 Pharmaceutical Preparation Manufacturing 171 325413 In-Vitro Diagnostic Substance Manufacturing 22 325414 Biological Product (except Diagnostic...Paakonen S, Parent RA (1996a) The mobility and degradation of acrolein in agricultural canals treated with Magnacide H Herbicide. Chemosphere , 32:807–814...1994) The assessment of bioaccumulation. Chemosphere 29, pp. 1501– 1514. Grosjean D and Grosjean E (1994). in Amer Chem Soc, Div Environm Chem Preprint

  10. Primary and Secondary Vestibular Connections in the Brain Stem and Cerebellum: An Axoplasmic Transport Study in the Monkey and Cat

    DTIC Science & Technology

    1983-08-25

    cervical, thoracic and lumbar levels were cut at 40 um on a freezing microtome. Selected sections were treated by the method described above for HRP...spinal cord of the rhesus monkey: A correlation of the findings of cytoarchl- tectonics and sympathectomy with fiber degeneration following dorsal...Stein, B.M. and Carpenter, M.B., Central projections of spinal dorsal roots in the monkey. I. Cervical and upper thoracic dorsal roots, Amer. J. Anat

  11. Symbiosis in Marine Luminous Bacteria

    DTIC Science & Technology

    1993-01-01

    products of V. fischer ! gapA genes suggest that this approach is not only easier, but has considerably more resolution than our previous efforts, and...1992) Detection of the light organ symbiont Vibrio fischeri in Hawaiian seawater using lux gene probes. Appl. Environ. Microbiol. 58:942-947. 3. Lee, K...H., and E.G. Ruby (1993) Evidence of viable but non-culturable symbiotic Vibrio fischeri in Hawaiian seawater. Abstr. Gen. Meet. Amer. Soc

  12. Medical Entomology Studies - IV. The Subgenera Indusius and Edwardsedes of the Genus Aedes (Diptera: Culicidae) (Contributions of the American Entomological Institute. Volume 13, Number 1)

    DTIC Science & Technology

    1976-05-21

    a tooth, smaller one simple. Abdomen . Terga with several short setae, mostly along lateral and posterior margins. Genitalia. Tergum IX with apex...setae absent. HaZter. Pedicel pale; capi- tellum white scaled. Abdomen . Tergum I white scaled with a few brown 6 Contrib. Amer. Ent. Inst., vol. 13, no...pale brown setae on margin; remigial setae absent. HaZter. Pedicel pale; capitellum pale brown scaled. Abdomen . Badly rubbed, Tergum I brown scaled

  13. Digital Image Restoration Under a Regression Model - The Unconstrained, Linear Equality and Inequality Constrained Approaches

    DTIC Science & Technology

    1974-01-01

    provided the necessary motivation for the development of the field. In particular, the work developed at the Jet Propulsion Laboratory [1-2] demon ...illumination and a reflected component. The assumption that the image is described by an array of cells whose content is given by the Maxwell ...Frieden, "Restoring with Maximum Likelihood and Maximum Entropy , " J. Opt. Soc. Amer., vol. 62, No. 4, pp. 511-518, April 1972. R.S. Hershel

  14. Testing Experimental Compounds against American Cutaneous and Mucocutaneous Leishmaniasis

    DTIC Science & Technology

    1982-06-01

    et al. 1975. Imported mucocutaneous leishmaniasis in New York City. Report of a case treated with Amphotericin B. Amer. J. Med. 59: 444-447. 7...absorption. In: Dermatological Formulations : Percutaneous Absorption, Marcel Dekker, Inc. New York, pages 127-145. 36, Croft, SI .D. Neame, and C.A. Homewood...No. DAMD 17-80-C-0061 Cornell University Medical College New York, New York 10021 -- Approved for public release; distribution unlimited. SThe findings

  15. The U.S. Navy and the Cuban Missile Crisis

    DTIC Science & Technology

    1990-05-22

    Herbert Hoover laid the foundation for Franklin D . Roosevelt’s 1933 enunciation of the Good Neighbor Policy which was intended to reduce Americ.a’s...Critics of the plan continued to surface as D -day approached. Under Secretary of State Chester Bowles advised strongly against proceeding "with this...Democrat J . William Fulbright, who had caught wind of the planned invasion. He pleaded with Kennedy not to proceed with the operation, which he

  16. Estimating an Image’s Blur Kernel from Edge Intensity Profiles

    DTIC Science & Technology

    2012-08-01

    spectrum of applications, including consumer photography , surveillance, computer vision, remote sensing, medical, and astronomical imaging. Simple...an astronomical picture, where the image of a faint star could be used as an estimate of the PSF.” What is not well known and I have yet to find an...J. Schulz, “Multiframe blind deconvolution of astronomical images”, J. Optical Soc. Amer., 10, pg. 10641073, 1993. 35 [18] L. Yuan, J. Sun, L. Quan,H

  17. The Electrocatalytic Reduction of Carbon Dioxide Using Macrocycles of Nickel and Cobalt.

    DTIC Science & Technology

    1980-10-24

    and Busch, Daryl H., J. Amer. Chem. Soc. 1974, 96, 3109; Rillema , D . Paul , Endicott, John F., and Papaconstantinous, Elias, Inorg. Chem. 1971; 10, 1739...NUMBER or PAGES MOt RnS LA N21 NAE 5A6R) is. SECURITY CLASS. (of m ape) Unclassified IS& :ftAkU=ICAIOMOOWGAOIN@ Is. OISTRIDUTION STATEMENT (of d ...these complexes in nonaqueous solvents has been previously reported.5 Each complex . .. ik. d & -2- undergoes uncomplicated reversible or

  18. A Network Thermodynamic Framework for the Analysis and Control Design of Large-Scale Dynamical Systems

    DTIC Science & Technology

    2006-03-31

    control for operating room hypnosis and intefisive care unit sedation. 1.3. Goals of this Report The main goal of this report is to summarize the...significant hysteresis in the actuator response. Specifically, smart distributed actuators such as shape memory alloys, magnetostrictives, electrorheolog- ical...and J. M. Bailey, "Nonlinear adaptive control for inten- sive. care unit sedation and operating room hypnosis ," in Proc. Amer. Contr. Conf., pp. 1808

  19. Generalizability Theory: 1973-1980,

    DTIC Science & Technology

    1981-07-01

    study. In order to reduce a6 , n’ may be increased. This is analogous to the Spearman- Brown prophecy for- mula in classical theory and the standard error...were un- linked, and so applied the Spearman- Brown formula inappropriately. The more general questions that need to be addressed in further research are...December 1977 (b). - Algoritmas , Procedures, and Variance Components for Analysis of Variance (ACT Technical Bulletin No. 31), .owa City, Iowa: Amer

  20. Instantaneous Power Spectrum

    DTIC Science & Technology

    1990-03-01

    O.0) AMAX=O AMIN=AMAX DO 10 1=1,L DO 20 N=-?1,M IF ( ((14-N) .GE. 1) .AND. ((14-N) .LE. L) )THEN COFF (M+N+1)=DATA(I14N) + , (0. 54+0. 46*COS(2*PI*N...Time Spectral Histories ," Acoust. Soc. Amer. , Vol. 59, No. 2, pp. 381-388, February 1976. Lampard, D.G., "Generalization of the Wiener-Khintchine

  1. Property Screening and Evaluation of Ceramic Turbine Engine Materials

    DTIC Science & Technology

    1979-10-01

    doped with 1% MgO, 8% Y2 03, and 15% Y20 3 ) were of lower strength than the Norton NC-132 and NCX- 34 materials, Slow crick growth was in evidence...T.L. Francis and R.L. Coble, "Creep of Polycrystalline Silicon Carbide," Jour. Amer. Ceram. Soc., 51(2) pp. 115-6 (1968). 44. P.L. Farnsworth and R.L

  2. A Study of Strategic Lessons Learned in Vietnam. Volume VI. Conduct of the War. Book I. Operational Analyses

    DTIC Science & Technology

    1980-05-09

    Starlite ), the Mpirines first sealed off the peninsula and then attacked to clear it. After a tough two-day fight with a well-intrenched and concealed...amphibious operations was Operation Starlite , in which a landing on the beach of Van Tuong Peninsula was coordinated with a helicopter borne assault and...old Starlite battlefield. Bold Mariner was the largest Special Landing Force effort of the war. The operation was joined by the Americal Division in

  3. Guidelines for Terrestrial Ecosystem Survey.

    DTIC Science & Technology

    1980-05-01

    McIntosh, Robert P., The Forest of the Catskill Mountains , New York (Cornwallville, New York: Hope Farm Press, 1977), 27 pp. Parkhurst, Howard Elmore...1976. 67 Allen, Joel A., "On Mammals From the Santa Cruz Mountains ," Bulletin American Museum of Natural __His r (1893), pp 263-270. Allen, Joel Asaph... Mountain Region," Journal of Wildlife Management, Vol 22 (1958), pp 395-402. Howell, A. H., "Revision of the North American Ground Squirrels," N. Amer. Fauna

  4. Ternary Solid Phase Equilibria in the Systems (Ag,In,Au)-(Cd,He)-Te

    DTIC Science & Technology

    1988-07-22

    thermochemnical data. In closed thermodynamic systems Ag,In, and Au were shown to be stable with respect to stoichiometric CdTe and Ag, In reactive towards...compositions within Codes Avail and/or 2lit Specilal the six ternary systems. Thermodynamic calculations were performed using the data collected in... Thermodynamic Properties of the Elements, (Amer.Chem.Soc., Washington, D.C., 1956) 11) John H. Pugh, Masters Thesis, UCLA, 1986-unpublished. 12) W.G

  5. The Science and Politics of Ethnic Enumeration,

    DTIC Science & Technology

    1980-01-01

    of America pointed out to the Bureau that "The number of Taiwanese-Amer- icans in this country is approaching 100,000. . . . These inmigrants -14...as has been the case of immigrants to America . According to an idea articulated as early as 1782 and gaining currency throughout the 19th and early...20th centuries, America was destined to be a melting pot of immigrant ethnic groups, each losing its separate identity in a new blend that drew the

  6. HMX: 13 Week Toxicity Study in Mice by Dietary Administration

    DTIC Science & Technology

    1985-07-31

    all values fell within expected ranges. Statistically signifi- cant differences were occasionally obtained in PCV , IiMCH, MCV and HepatoQuick time...34 ~0 14- 0 4, (,;. .’,,,° CDC .4.4 ’-’ . tp n .. 00 .4 _.,,i I (A 4- 0)0 -44 -, 0 ,) _ -4 to 4 to 4o...et al, Volume: ( PCV ) Amer. J. Path., 24, 1016, (1954). % Absolute Values: Mean Cell "Volume: (MCV) fl Mean Cell Haemoglobin: Haematological Slide

  7. Constrained Regularization for Ill Posed Linear Operator Equations, with Applications in Meteorology and Medicine.

    DTIC Science & Technology

    1981-08-01

    Anderssen, DeHoog and Lukas (1980), Golberg (1978), Tihonov and Arsenin (1977), Twomey (1977), Nashed (1981). I I -9- 3. Cross validation for...reuse method with applications. J. Amer. Statist. Assoc., 70, 320-328. Golberg , M.A. (1978), ed. "Solution methods for integral equations, Theory and... Golberg , ed., Plenum Press, 183-194. Wahba, G. (1979b). Convergence rates of "thin plate" smoothing splines when the data are noisy in "Smoothing

  8. Effects of Ionizing Radiation on Auditory and Visual Thresholds

    DTIC Science & Technology

    1992-03-01

    intact organism. A direct assessment of functional alterations in the intact organism as a result of radiation exposure, however, can be provided by a...motor function in non-human primates. There are data (reviewed by Kimmeldorf and Hunt; ref 3) suggesting that alterations in auditory and visual...Old World monkeys (Cercopithecinae). Amer. J. Rhya. Anthrop ., 1973, X 357-364. 6. Fay, R.R. Auditory frequency discrimination in vertebrates. 1

  9. US Arms Transfer Policy for Latin America: Lifting the Ban on Fighter Aircraft

    DTIC Science & Technology

    1999-01-01

    not the only con tender for their upcom ing purchase of per haps as many as 60 fighters.41 During the 1998 Ferie In ter na cional del Aire y del Espa ...Source: Adam Isaac son and Jay Ol son,Just the Facts: A Civili an’s Guide to U.S. De fense and Se cu rity As sis tance to Latin Amer ica and the Car ib

  10. The Impact of Intensive Insulin Protocols and Restrictive Blood Transfusion Strategies on Glucose Measurement in American Burn Association (ABA) Verified Burn Centers

    DTIC Science & Technology

    2008-10-01

    by both studies, as was demonstrated by a survey conducted by Palmieri and Greenhalgh7 in which multiple centers reported using low transfusion...phenomenon, whereas others continue to use glucometers because of the lack of a viable alternative. Our hypothesis for this survey was that most Amer...obtained from the nurse in charge of the unit, when that person could be identified, or a staff nurse. A three-question survey was formulated and

  11. Time Resolved Flow Velocity and Concentration Measurements Using a Travelling Thermal Lens.

    DTIC Science & Technology

    2014-09-26

    R. J. Adrian and C. Yao, Appi . Opt. 24, 44 (1985). 5. E. J. Shaughnessy and J. B. Morton, J. Fluid Mechanics 80, 129 (1977). 6. A. E. Perry, T. T...Amer and R. Gerlach, Appi . Phys. Lett. 37, 519 (1980). 11. A. Rose, J. D. Pyrum, C. Muzny, G. 1. Salamo and R. Gupta, AppL. Opt. 21, 2663 (1982). 12. A

  12. Training, Muscle Fatigue and Stress Fractures.

    DTIC Science & Technology

    1992-07-29

    Ted & Micheli, L. (1988): Bone stress lesions in ballet dancers: Scintigraphic assessment. Amer. J. Radiology 150:851-855. Parfitt, A.M., Drezner...factors responsible for the stress fracture lesion . Over this period, the research has focussed exclusively on an animal model developed specifically...stimulates this debilitating condition. Previous work from our group suggests that the lesion is a product of tissue remodeling (intracortical porosis

  13. Standing Down a Joint Task Force

    DTIC Science & Technology

    1995-01-01

    maintains a small American military presence in Hon- duras at a facility known as Soto Cano Air Base. Joint Task Force-Bravo (JTF–B), directly...medivac heli- copter capability, and assists Hon- duras in counterdrug actions.1 Since the United States has no base leasing agreement, its military...example, SOUTHCOM points out that JTF–B contributes millions of dollars annu- ally to the local economy of Comay- agua and that the departure of Amer

  14. A Robust Estimator of the Difference between Location Parameters of Correlated Variables for Fragmentary Samples.

    DTIC Science & Technology

    1980-04-01

    E. J. (1961). Bivariate logistic distributions, J. Amer. Statist . Assoc. 56, 335-349. Cupta, A. K. and Rohatgi , V. K. (1979). Inference on the...Science, and Statistics Columbia, South Carolina 29208 4 4, AUG 1 5 1980 A 4111 *Research supported by the United States Air Force Office of Scientific...Carolina AREA & WORK UNIT NUMBERS Department of Mathematics, Compt Sci. & Statistics Columbia, SC 29208 61102F 2304/A5 II. CONTROLLING OFFICE NAME AND

  15. A Converse of the Mean Value Theorem Made Easy

    ERIC Educational Resources Information Center

    Mortici, Cristinel

    2011-01-01

    The aim of this article is to discuss some results about the converse mean value theorem stated by Tong and Braza [J. Tong and P. Braza, "A converse of the mean value theorem", Amer. Math. Monthly 104(10), (1997), pp. 939-942] and Almeida [R. Almeida, "An elementary proof of a converse mean-value theorem", Internat. J. Math. Ed. Sci. Tech. 39(8)…

  16. A Study of the Operator Expansion Method and its Application to Scattering from Randomly Rough Dirichlet Surfaces

    DTIC Science & Technology

    1994-06-01

    integrated optics [ Marcuse , 19821, as well as in ocean acoustics [DeSanto, 1979]. I Many applications emphasize the solution of the inverse problem: the...Berlin, 1980. Carsey, F. D. ed., Microwave Sensing of Sea Ice, Geophysical Monograph 68 , Amer- ican Geophysical Union, 1992. Chen, J. S., and A... Marcuse , D., Light Transmission Optics, Van Nostrand Reinhold, New York, 1982. 3 McDaniel, S.T., "Sea surface reverberation: A review," J. Acoust. Soc

  17. Scour Mechanics of Aggregate Obstacle Fields With Application to Mine Countermeasures

    DTIC Science & Technology

    2016-06-07

    farfield burial mechanisms are presently formulated by changes in the equilibrium bottom profiles associated with seasonal changes in wave climate ...Jenkins, 1998, “Erosion cycle of coastal drainage basins due to climate change ,” EOS, Amer. Geophys. Union Trans., vol. 79, no. 45, p. F371. Jenkins...Inman, D. L. & S. A. Jenkins, 1999, “ Climate change and the episodicity of sediment flux of small California rivers,” Jour. Geology, vol. 107, no. 3

  18. Metals Additive ManufacturingGreat Promise in Mitigating Shortages but Some Risks Remain

    DTIC Science & Technology

    2016-12-01

    Defense AT&L: November-December 2016 38 Metals Additive Manufacturing Great Promise in Mitigating Shortages but Some Risks Remain Drew Miller n...initiatives such as establishing “Amer- ica Makes”—the National Additive Manufacturing Innovation Institute—and funding some AM-related Manufacturing Tech...NIST) is funding research to pro- vide quality assurance of AM parts. The DoD Metals Additive Manufacturing Qualification and Certification Working

  19. Energy Efficiency of Sea and Air Vehicles.

    DTIC Science & Technology

    1978-08-30

    B-58 Hustler (G-97 at F-36) and B-70 Valkyrie (G-108 at F-35). The B-1 design datum is at G-86 and F-26. The Three Soviet bombers Beagle, Bison and...THRUST 20400 LB 90.7473 KN E= 4.69951 F= 18.4661 G= 86.7816 B-70 NO AMER VALKYRIE LENGTH 189 FT 57.6072 N WEIGHT 568300 LB 257781. KG 253.705 LT SPEED

  20. The Structure-Mapping Engine: Algorithm and Examples.

    DTIC Science & Technology

    1987-07-01

    08540 Ann Arbor. MI 48109 Dr Sherrie Gott AFHRL MODJ Dr Wayne Harvey Ms Julia S Hough BrooKs AFB TX 78235 SRI International Lawrence Eribaum Associates...Performance Lanoratory Department of Psychology Catholic University of Evanston IL 60201 Amer~ca Dr Wayne Gray Wasnington. DC 20064 Army Research Institute...22333 Norcross, GA 30092 Dr Sylvia A S Shafto Department of Computer Science Dr Lynne Recer Dr David Rumelhart Towson State University Department of

  1. Influence of Partial Coherence on Light Transmission and on Image Formation.

    DTIC Science & Technology

    1982-12-01

    characterization of light beams generated by Schell - model sources whose intensity distribution and degree of coherence are both Gaussian was found; it bears a...E. WOLF: "Radiation from Anisotropic Gaussian Schell - Model Sources" [Opt. Lett., 7, 256-258 (1982)]. 15. A. STARIKOV and E. WOLF: "Coherent-Miode...Representation of Gaussian Schell - Model Sources and of Their Radiation Fields" [J. Opt. Soc. Amer., 72, 923-928 (1982)]. 16. G.S. AGARWAL, A.T. FRIBERG

  2. Selected Bibliography on Optimizing Techniques in Statistics

    DTIC Science & Technology

    1981-08-01

    1958). Iterative solutions of likelihood equations, Biometrika 14, 128-130. Unland, A. W. and Smith , W. N. (1959). The use of Lagrange multipliers...373. IKubicek, M. Marek, M. and Eckert E. (1971). Quasilinearized regression, Technometrics 13 (3), 601-608. I Smith , F. B. and ham, D. F. (1971). Pm...parameter, J. Amer. Statist. Ass. 67, 641-646. Theobald , C. M. (1975). An inequality with application to nultivariate analysis, Bicmetrika 62, 461-466

  3. Mesoscale Surface Pressure and Temperature Features Associated with Bow Echoes

    DTIC Science & Technology

    2010-01-01

    contain several bowing segments. These multiple segments could occur at the same time and be located within the same bow, such as the serial derecho ...Examination of derecho environments using proximity soundings. Wea. Forecasting, 16, 329–342. Fovell, R. G., 2002: Upstream influence of numerically...Se- vere Local Storms, Hyannis, MA, Amer. Meteor. Soc., 4.6. Johns, R. H., and W. D. Hirt, 1987: Derechos : Widespread con- vectively induced

  4. Spatial Disorientation - A Perspective

    DTIC Science & Technology

    2003-02-01

    requirement of normal vestibular function in potential aviators. This led to the use of the Barany rotation test in the medical selection of pilots. Applicants...found no correlation between performance on the Barany test and flying ability. Indeed, experienced pilots were found, on average, to have a shorter...Ocker WC (1930) Blind Flying. J. Aviat. Med., 1, 132-150. Parsons RP & Segar LH (1918) Barany chair tests and flying ability. J. Amer. Med. Assoc

  5. Modeling of Mid-Frequency Reverberation in Very Shallow Water: A Green’s Function Approach and Application to TREX2013 Data Analysis

    DTIC Science & Technology

    2015-08-31

    inversion , TREX13 data analysis and model-data comparisons. Distribution Statement A: Approved for public release; distribution unlimited. 2...inputs. Also, it was suggested to consider analytical expressions for reverberation, methods of its inversion for environmental parameters, and...1913), “Physics-based inversion of multibeam sonar data for seafloor characterization”, J. Acoust. Soc. Amer., 134(4), Pt.2, p.4240. B.T. Hefner

  6. TIL: A Type-Directed Optimizing Compiler for ML.

    DTIC Science & Technology

    1996-02-29

    Conference on Program - ming Language Design and Implementation, Philadelphia, Pennsylvania, May 21-24, 1996. It is also published as Fox Memorandum...Conference on Programming Language Design and Implementation, pages 85-94, Atlanta, Georgia, June 1988. ACM. [14] A. Demers, M. Weiser, B. Hayes, H...on Programming Language Design and Implementation, pages 273-282, San Francisco, CA, June 1992. ACM. [16] Amer Diwan, David Tarditi, and Eliot Moss

  7. North Pacific - North American Circulation and Precipitation Anomalies Associated With the Madden-Julian Oscillation

    DTIC Science & Technology

    2006-03-01

    Amer. Meteor. Soc., 77, 1275-1277. Lorenz, D. J., and D. L. Hartmann, 2006: The effect of the MJO on the North American Monsoon . J. Climate ...extratropical wave train extending from southeast Asia into the NPNA region. ................................................ 92 Figure 55. Wheeler phase...extratropical wave train extending from southeast Asia into the NPNA region......................... 98 Figure 59. 200-hPa height anomaly for a composite of

  8. Eye Movements and Spatial Pattern Vision

    DTIC Science & Technology

    1989-07-15

    models to color, e.g., Land’s retinex model . It is now clear that the chromatic version of our model cannot be a mere replication of the achromatic model ...adaptation constancy mechanisms and simultaneous mechanisms. B. Model Development Our basic thresholded-gradient-integration model provided crude...publication of papers on our initial chromatic constancy measurements (J. Opt. Soc. Amer. A, 1986) and the thresholded-gradient-integration model

  9. Nanofiber-Based Bulk-Heterojunction Organic Solar Cells Using Coaxial Electrospinning

    DTIC Science & Technology

    2012-01-01

    Coates , W. L. Ma , D. Moses , A. J. Heeger , G. C. Bazan , Nat. Mater. 2007 , 6 , 497 – 500 . [ 29 ] J. K. Lee , W. L. Ma , C. J...Brabec , J. Yuen , J. S. Moon , J. Y. Kim , K. Lee , G. C. Bazan , A. J. Heeger , J. Amer. Chem. Soc. 2008 , 130 , 3619 – 3623...Heeger , G. C. Bazan , Acc. Chem. Res. 2009 , 42 , 1700 – 1708 . [ 3 ] A. J. Moulé , K. Meerholz , Adv. Funct. Mater. 2009 , 19

  10. Thermal Inactivation of Viruses

    DTIC Science & Technology

    1977-10-01

    Hammon. 1966. Studies on Japanese B encephalitis virus vaccines from tissue culture. VI. Development of a hamster kidney tissue culture inactivated... tissue culture passage, storage, temperature and drying on viability of SE polyoma virus. Exper. Biol. and Hed. Proc. of the Soc. for Exper. Biol...studies of heated tissue suspensions containing foot- and-mouth disease virus. Amer. J. Vet. Res. 20:510-521. Dupre’, M. V., and M. Frobisher. 1966

  11. 12 CFR 220.119 - Applicability of margin requirements to credit extended to corporation in connection with...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., was “purchasing” the 4,161 shares of its stock, within the meaning of that term as used in this part... use of credit; its outstanding stock was simply reduced by 4,161 shares. (f) The meaning of “sale” and... with the literal words. U.S. v. Amer. Trucking Ass'ns, 310 U.S. 534, 543 (1940); 2 Sutherland...

  12. Fine Scale Analysis of the Kinematic, Dynamic and Thermodynamic Features of a Multiple Microburst-Producing Storm

    DTIC Science & Technology

    1990-01-01

    LacaL Stnrms. San Antonio, Tx. Amer. Meteor. Soc., 272-275. Chong, M., P. Amayenc, G. Scialom, and J. Testud , 1987: A tropical squall line observed... Testud , 1983: Three-dimensional wind field analysis from dual-Doppler radar data. Part III: The boundary condition: An optimum determination based...Stephens, W. C. Bumgarner, and E. A. Mueller, 1978: Triple-Doppler observations of a convective storm. L Apl Meteor., 1L 1201-1212. Roux, F., J. Testud , M

  13. Algorithms for Robust Identification and Control of Large Space Structures. Phase 1.

    DTIC Science & Technology

    1988-05-14

    Variate Analysis," Proc. Amer. Control Conf., San Francisco, * pp. 445-451. LECTIQUE, J., Rault, A., Tessier, M., and Testud , J.L. (1978), "Multivariable...Rault, J.L. Testud , and J. Papon (1978), "Model Predictive Heuris- tic Control: Applications to Industrial Processes," Automatica, Vol. 14, pp. 413...Control ’. Conference, Minneapolis, MN, June. TESTUD , J.L. (1979), "Commande Numerique Multivariable du Ballon de Recupera- tion de Vapeur," Adersa/Gerbios

  14. Capacity Building and Financing Oral Health in the African and Middle East Region.

    PubMed

    Mumghamba, E G; Joury, E; Fatusi, O; Ober-Oluoch, J; Onigbanjo, R J; Honkala, S

    2015-07-01

    Many low- and middle-income countries do not yet have policies to implement effective oral health programs. A reason is lack of human and financial resources. Gaps between resource needs and available health funding are widening. By building capacity, countries aim to improve oral health through actions by oral health care personnel and oral health care organizations and their communities. Capacity building involves achieving measurable and sustainable results in training, research, and provision of care. Actions include advancement of knowledge, attitudes and skills, expansion of support, and development of cohesiveness and partnerships. The aim of this critical review is to review existing knowledge and identify gaps and variations between and within different income levels in relation to the capacity building and financing oral health in the African and Middle East region (AMER). A second aim is to formulate research priorities and outline a research agenda for capacity building and financing to improve oral health and reduce oral health inequalities in the AMER. The article focuses on capacity building for oral health and oral health financing in the AMER of the IADR. In many communities in the AMER, there are clear and widening gaps between the dental needs and the existing capacity to meet these needs in terms of financial and human resources. Concerted efforts are required to improve access to oral health care through appropriate financing mechanisms, innovative health insurance schemes, and donor support and move toward universal oral health care coverage to reduce social inequality in the region. It is necessary to build capacity and incentivize the workforce to render evidence-based services as well as accessing funds to conduct research on equity and social determinants of oral health while promoting community engagement and a multidisciplinary approach. © International & American Associations for Dental Research 2015.

  15. Basic Research in Electronics (JSEP)

    DTIC Science & Technology

    1989-12-31

    a huge lateral beam shift of the Goos Hanchen type has already been reported [15]. All these considerations indicate that the presence of nonlinear...effects which include not only large lateral beam displacements, but also focal and angular beam shifts , anomalous absorption phenomena and strong...pp. 549-574. [6] V. Shah and T. Tamir, "Absorption and lateral shift of beams incident upon lossy multilayered media", J. Opt. Soc. Amer. 73, pp. 37

  16. The KRAKEN Normal Mode Program

    DTIC Science & Technology

    1992-05-22

    Gaussian beam tracing referred to as geometric beam tracing. For those familiar with tradi- tional implementations of ray tracing, the results are often...and Homer P. Bucker, " Gaussian beam tracing for computing ocean acoustic fields," J. Acoust. Soc. Amer. 82, 1349-1359 (1987). The following programs...are used with BELLHOP: BELLHOP Main program for doing Gaussian beam tracing PLOTRAY Produces plots of central rays of beams ANGLES Given the source and

  17. Feasibility Study of Pharmacological Treatment to Reduce Morbidity and Mortality after Brain Injury.

    DTIC Science & Technology

    1987-05-01

    Electroconvulsive therapy in patients with Parkinsonism. Amer. J. Psychiat. 132:457. 43. Lowry O. H., Rosebrcugh N. S. , Farr A. C., Randall R. J. (1951). Protein...agonists and antagonists. Ii Farmaco Edizione Scientifica, 35, 535-550. 50. Modigh K., (1976). Long-term effects of electroconvulsive shock therapy on... electroconvulsive seizures (ECS) using a model of cortical contusion on recovery of beam-walking ability. Rats were given a single drug or saline injection (i.p

  18. Study in the Area of Satellite Meteorology. Volume 1. Mesoscale Weather Analysis and Prediction

    DTIC Science & Technology

    1974-11-01

    and E. J. Wiegman , "Study of Time-Lapse Processing for Dynamic Hydrologie Conditions," Final Report, NASA Contract NAS5-21841...J. Wiegman , R. G. Hadfield, and W. E. Evans, "Electronic System for Utilization of Satellite Cloud Pictures, " Bull. Amer...Photographs," S~mp Research Paper 71, University of Chicago, Chicago, Ill., 25 pp. (1968). 21. S. M. Serebreny, E. J. Wiegman , R. G. Hadfield, and W. E

  19. Physiological Adaptations of Arctic Mammals.

    DTIC Science & Technology

    1975-01-01

    simuttaneousLv with our own. one at the Amer- loan Society of Zoologists ’ meeting (1973). and one at the Federation Meeting (FASEB. 1974). The perspective on...Deirek Craighead Journal: The American Zoologist Status: In Press; one page Coordination with Program: This is an experiment of very long standing...the Office of Naval Research under contract # N00014-7S-C-063S (Subcontract ONR-455). Reference: American Zoologist 16: (in press) 1976. i . "- - , . o

  20. Existence of viscosity solutions of Hamilton-Jacobi equations

    NASA Astrophysics Data System (ADS)

    Souganidis, Panagiotis E.

    Equations of Hamilton-Jacobi type arise in many areas of application, including the calculus of variations, control theory and differential games. Recently M. G. Crandall and P.-L. Lions ( Trans. Amer. Math. Soc.277 (1983), 1-42) introduced the class of "viscosity" solutions of these equations and proved uniqueness within this class. This paper discusses the existence of these solutions under assumptions closely related to the ones which guarantee the uniqueness.

  1. Determinants of Oral Diseases in the African and Middle East Region.

    PubMed

    Chidzonga, M M; Carneiro, L C; Kalyanyama, B M; Kwamin, F; Oginni, F O

    2015-07-01

    Oral health policies must be developed that emphasize the role of social determinants in health and oral diseases. The aim of this report is to review literature on determinants of oral diseases and apply the concepts to promoting oral health in the African countries in the African and Middle East region (AMER). Structural and proximal determinants of oral diseases are common to those affected by other noncommunicable diseases (NCDs). Oral diseases are also heavily affected by issues of politics, poor health behaviors, underdeveloped health systems, and low oral health literacy. Wide-scale poverty exists in populations in the AMER. Oral health promotion and preventive oral health programs should therefore be integrated with those for general health and use the common risk factor approach (CRFA). Attempts should be made to improve the daily living conditions and reduce the incline of the social gradient. Oral health practitioners should use the CRFA when dealing with determinants of oral diseases and in the design of preventive oral health programs. The detrimental effects of the social determinants of health may be ameliorated by involving both the individual and community. Interventions in health promotion programs in the AMER need more research on the epidemiology of oral diseases and the role played by the social determinants of oral diseases, especially with regard to poverty. The high levels of poverty and low gross domestic product in most countries in the African region make it difficult to fund high-quality, affordable, accessible oral health services. © International & American Associations for Dental Research 2015.

  2. Comparison of Self-Reported Telephone Interviewing and Web-Based Survey Responses: Findings From the Second Australian Young and Well National Survey.

    PubMed

    Milton, Alyssa C; Ellis, Louise A; Davenport, Tracey A; Burns, Jane M; Hickie, Ian B

    2017-09-26

    Web-based self-report surveying has increased in popularity, as it can rapidly yield large samples at a low cost. Despite this increase in popularity, in the area of youth mental health, there is a distinct lack of research comparing the results of Web-based self-report surveys with the more traditional and widely accepted computer-assisted telephone interviewing (CATI). The Second Australian Young and Well National Survey 2014 sought to compare differences in respondent response patterns using matched items on CATI versus a Web-based self-report survey. The aim of this study was to examine whether responses varied as a result of item sensitivity, that is, the item's susceptibility to exaggeration on underreporting and to assess whether certain subgroups demonstrated this effect to a greater extent. A subsample of young people aged 16 to 25 years (N=101), recruited through the Second Australian Young and Well National Survey 2014, completed the identical items on two occasions: via CATI and via Web-based self-report survey. Respondents also rated perceived item sensitivity. When comparing CATI with the Web-based self-report survey, a Wilcoxon signed-rank analysis showed that respondents answered 14 of the 42 matched items in a significantly different way. Significant variation in responses (CATI vs Web-based) was more frequent if the item was also rated by the respondents as highly sensitive in nature. Specifically, 63% (5/8) of the high sensitivity items, 43% (3/7) of the neutral sensitivity items, and 0% (0/4) of the low sensitivity items were answered in a significantly different manner by respondents when comparing their matched CATI and Web-based question responses. The items that were perceived as highly sensitive by respondents and demonstrated response variability included the following: sexting activities, body image concerns, experience of diagnosis, and suicidal ideation. For high sensitivity items, a regression analysis showed respondents who were male

  3. Helminth fauna of Eurasian lynx (Lynx lynx) in Estonia.

    PubMed

    Valdmann, H; Moks, E; Talvik, H

    2004-04-01

    Thirty-seven carcasses of Eurasian lynx (Lynx lynx) collected and examined in Estonia during 1999-2001 had helminths. Parasites identified and their prevalence included Diphyllobothrium latum (5%), Taenia pisiformis (100%), Taenia laticollis (41%), Taenia hydatigena (3%), Taenia taeniaeformis (3%), Toxocara cati (68%), and Trichinella spp. (22%). The only significant relationships (P < or = 0.05) between occurrence of helminths and host age and sex were a greater number of T. pisiformis and T. laticollis in older than in youger male lynx, and older males had a greater number of species of helminth than did younger lynx. Sixty-one fecal samples collected during snow tracking of nine lynx were examined; eggs of T. cati were identified in 38 samples, and Capillaria spp were found in eight samples. This is the first systematic investigation of parasites of lynx in Estonia.

  4. Toxocara malaysiensis infection in domestic cats in Vietnam--An emerging zoonotic issue?

    PubMed

    Le, Thanh Hoa; Anh, Nguyen Thi Lan; Nguyen, Khue Thi; Nguyen, Nga Thi Bich; Thuy, Do Thi Thu; Gasser, Robin B

    2016-01-01

    Toxocara canis of canids is a parasitic nematode (ascaridoid) that infects humans and other hosts, causing different forms of toxocariasis. This species of Toxocara appears to be the most important cause of human disease, likely followed by Toxocara cati from felids. Although some studies from Malaysia and China have shown that cats can harbor another congener, T. malaysiensis, no information is available about this parasite for other countries. Moreover, the zoonotic potential of this parasite is unknown at this point. In the present study, we conducted the first investigation of domestic dogs and cats for Toxocara in Vietnam using molecular tools. Toxocara malaysiensis was identified as a common ascaridoid of domestic cats (in the absence of T. cati), and T. canis was commonly found in dogs. Together with findings from previous studies, the present results emphasize the need to explore the significance and zoonotic potential of T. malaysiensis in Vietnam and other countries where this parasite is endemic and prevalent in cats.

  5. Potential Applications of Cable Television (CATV) to the FEMA (Federal Emergency Management Agency) Communications Mission.

    DTIC Science & Technology

    1983-07-01

    8217D-RI31 326 POTENTIAL APPLICATIONS OF CABLE TELEVISION (CATY) TO i2 THE FEMA (FEDERAL EM.. (U) CONTROL ENERGY CORP BOSTON MR D D GILLIGAN ET AL. JUL...9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK AREA & WORK UNIT NUMBERS Control Energy Corporation 470 Atlantic...Avenue Boston, MA 02210 ______________ 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE Federal Emergency Management Agency July, 1983 OAM

  6. Water-free titania-bronze thin films with superfast lithium-ion transport.

    PubMed

    Zhang, Kui; Katz, Michael B; Li, Baihai; Kim, Sung Joo; Du, Xianfeng; Hao, Xiaoguang; Jokisaari, Jacob R; Zhang, Shuyi; Graham, George W; Van der Ven, Anton; Bartlett, Bart M; Pan, Xiaoqing

    2014-11-19

    Using pulsed laser deposition, TiO2 (-) B and its recently discovered variant Ca:TiO2 (-) B (CaTi5O11) are synthesized as highly crystalline thin films for the first time by a completely water-free process. Significant enhancement in the Li-ion battery performance is achieved by manipulating the crystal orientation of the films, used as anodes, with a demonstration of extraordinary structural stability under extreme conditions.

  7. Gastrointestinal parasites of cats in Denmark assessed by necropsy and concentration McMaster technique.

    PubMed

    Takeuchi-Storm, N; Mejer, H; Al-Sabi, M N S; Olsen, C S; Thamsborg, S M; Enemark, H L

    2015-12-15

    The large population of feral cats in Denmark may potentially transmit pathogens to household cats and zoonotic parasites to humans. A total of 99 euthanized cats; feral cats (n=92) and household cats with outdoor access (n=7), were collected from March to May 2014 from the Zealand region, Denmark. The sedimentation and counting technique (SCT) was used to isolate helminths and coproscopy was done by concentration McMaster technique (c-McMaster). Overall, 90.1% of the cats were infected and a total of 10 species were recorded by SCT: 5 nematode species: Toxocara cati (84.8%), Ollulanus tricuspis (13.1%), Aonchotheca putorii (7.1%), Paersonema spp. (3.0%), Strongyloides spp. (1.0%); 3 cestodes: Hydatigera taeniaeformis (36.4%), Mesocestoides sp. (3.0%), Dipylidium caninum (1.0%); and 2 trematodes: Cryptocotyle spp. (5.1%) and Pseudamphistomum truncatum (1.0%). O. tricuspis was the second most common gastrointestinal nematode of cats but had the highest intensity of infection. For T. cati, prevalence and worm burden were significantly higher in feral than household cats. No juvenile cats were infected with H. taeniaeformis, and age thus had a significant effect on prevalence and worm burdens of this species. Rural cats had a higher prevalence and worm burden of A. putorii than urban cats. By c-McMaster, ascarid, capillarid, strongylid or taeniid type eggs were found in 77.9% of the cats while Cystoisospora felis was found in 2.1%. The sensitivity of the c-McMaster was 82.5% for T. cati but 26.5% for taeniid eggs, using the SCT as gold standard. A positive correlation between faecal egg counts and worm burdens was seen for T. cati, but not for taeniid eggs (assumed to be H. taeniaeformis). Coprological examination also detected the eggs of extraintestinal Capillariidae species including Eucoleus aerophilus and Eucoleus boehmi, but further necropsy studies are needed to confirm these findings.

  8. Decontamination/Cleanup Operations for the Leaseback Area of Alabama Army Ammunition Plant, Alabama. Environmental Assessment.

    DTIC Science & Technology

    1981-08-01

    UNIT NUMBERS US Army Toxic and Hazardous Materials Agency Aberdeen Proving Ground, MD 21010 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE US...different fhu Controlling Office) IS. SECURITY CLASS. (of this report) Unclassi fied IS&. DECL ASSI FlCATI ON DOWNGRADING SCHEDULE 16. DISTRIBUTION... controlled length. These were transported by means of solvent recovery cars to the Solvent Re- covery Buildings. (2) In the Solvent Recovery

  9. 76 FR 36898 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... American Community Survey. OMB Control Number: 0607-0810. Form Number(s): ACS-I, ACS-I(SP), ACS-I(PR), ACS-I(PR)(SP), ACS- I(GQ), ACS-I(PR)(GQ), GQFQ, ACS CATI (HU), ACS CAP I (HU), ACS (HU) Reinterview, GQ... Community Survey (ACS). The Census Bureau has developed a methodology to collect and update every...

  10. RF Sytems in Space. Volume II. Space-Based Radar Analyses.

    DTIC Science & Technology

    1983-04-01

    phase compensation., If distortion is to - 16 .. . . .. . .. ....... ,.._ 2. If the ditrto error are....r.. td te-nt-o-...n...1_ be compensated, it must...TWdutCAL 4t Me~id4"f otb,~4* catiL au.t- -£IwU@F &aQtJU" L~ eUM &o ae 4-. . .. ... .. , -,I,-. FILMED

  11. Study of Aerospace Materials, Coatings, Adhesions and Processes. Aircraft Icing Processes. Volume 1.

    DTIC Science & Technology

    1984-09-14

    AP A160 413 STUDY OF AEROSPACE MATERIALS CATIS AD|SIOS A - PROCESSES AIRCRAFT IC.. (UI INSTITUbO NACIONAL DE TECNICA AEROESPACIAL MORID ISPAIN) E I...Approved for public release; distribution unlimited. Prepared for INSTITTTTO NACIONAL DE TECNICA AEROESPACIAL "Esteban Terradas". Torrejdn de Ardoz...ADDRESS il0. PROGRAM ELEMENT. PROJECT, TASKC Thstituto Naciorial Tecnica Aeroespacial Dto. Aerodindmica y Navegabilidad 2301 / D1 Torrejcn de Ardoz

  12. Endoparasites of Eurasian lynx (Lynx lynx) (Linnaeus, 1758) from an enclosure of Western Pomeranian Nature Society in Jablonowo

    PubMed

    Filip, Katarzyna J; Demiaszkiewicz, Aleksander W

    The aim of this study was to describe parasites of three lynx living in an enclosure of Western Pomeranian Nature Society in Jablonowo. During analysis of 3 gram faecal samples eggs of Toxascaris leonina, Toxocara cati, Ancylostoma sp. and oocysts of Cystoisospora felis were found. To our knowledge this is the first report of C. felis infection in lynx from Poland. Presented research show that wild cats in captivity are particularly exposed on parasitic infections and demand regular examination.

  13. Advances in molecular identification, taxonomy, genetic variation and diagnosis of Toxocara spp.

    PubMed

    Chen, Jia; Zhou, Dong-Hui; Nisbet, Alasdair J; Xu, Min-Jun; Huang, Si-Yang; Li, Ming-Wei; Wang, Chun-Ren; Zhu, Xing-Quan

    2012-10-01

    The genus Toxocara contains parasitic nematodes of human and animal health significance, such as Toxocara canis, Toxocara cati and Toxocara vitulorum. T. canis and T. cati are among the most prevalent parasites of dogs and cats with a worldwide distribution. Human infection with T. canis and T. cati, which can cause a number of clinical manifestations such as visceral larva migrans (VLMs), ocular larva migrans (OLMs), eosinophilic meningoencephalitis (EME), covert toxocariasis (CT) and neurotoxocariasis, is considered the most prevalent neglected helminthiasis in industrialized countries. The accurate identification Toxocara spp. and their unequivocal differentiation from each other and from other ascaridoid nematodes causing VLMs and OLMs has important implications for studying their taxonomy, epidemiology, population genetics, diagnosis and control. Due to the limitations of traditional (morphological) approaches for identification and diagnosis of Toxocara spp., PCR-based techniques utilizing a range of genetic markers in the nuclear and mitochondrial genomes have been developed as useful alternative approaches because of their high sensitivity, specificity, rapidity and utility. In this article, we summarize the current state of knowledge and advances in molecular identification, taxonomy, genetic variation and diagnosis of Toxocara spp. with prospects for further studies.

  14. Prevalence of intestinal parasites in private-household cats in Japan.

    PubMed

    Itoh, Naoyuki; Ikegami, Hiroshi; Takagi, Masahiro; Ito, Yoichi; Kanai, Kazutaka; Chikazawa, Seishiro; Hori, Yasutomo; Hoshi, Fumio; Higuchi, Seiichi

    2012-06-01

    The present study is the first national investigation of intestinal parasites in private-household cats in Japan. A total of 942 faecal samples were collected from private-household cats. Giardia species was assessed using an enzyme-linked immunosorbent assay kit and other intestinal parasites were identified microscopically. The overall prevalence of intestinal parasites was 10.1%; two protozoan parasites (Giardia species and Cystoisospora species) and five helminths (Toxocara cati, Toxascaris leonina, Ancylostoma tubaeforme, Taenia species and Spirometra erinacei) were detected. The total prevalence of intestinal parasite infection was significantly higher in cats aged ≤ 6 months old than in cats older than 6 months because of a significantly higher prevalence of Cystoisospora species and T cati. The total infection prevalence was higher among outdoor cats as a result of the significantly higher prevalence of T cati and S erinacei. Sex and faecal condition were not related to intestinal parasite infections. Regional differences were observed in Cystoisospora species and A tubaeforme.

  15. Toxocara canis: monoclonal antibodies to larval excretory-secretory antigens that bind with genus and species specificity to the cuticular surface of infective larvae.

    PubMed

    Bowman, D D; Mika-Grieve, M; Grieve, R B

    1987-12-01

    When maintained in culture, the infective-stage larvae of Toxocara canis produce a group of excretory-secretory antigens. Monoclonal antibodies to these antigens have been produced and partially characterized. Hybridomas were made using spleens from mice that had been given 250 embryonated eggs of T. canis followed by immunization with excretory-secretory antigens. Monoclonal antibodies were first screened against excretory-secretory antigens using an indirect enzyme-linked immunosorbent assay. Those antibodies positive in this assay were then screened against the surfaces of formalin-fixed, infective-stage larvae using an indirect fluorescent antibody assay. The two monoclonal antibodies showing fluorescence were also tested against the surfaces of infective-stage larvae of Toxocara cati, Baylisascaris procyonis, Toxascaris leonina, Ascaris suum, a Porrocaecum sp., and Dirofilaria immitis. One of these two antibodies bound to the surface of T. canis and T. cati while the other bound only to the surface of T. canis; neither were reactive with the other ascaridoid larvae or the larvae of D. immitis. Enzyme-linked immunoelectrotransfer blotting techniques were used to demonstrate that the cross-reactive antibody recognized antigens with molecular weights of about 200 kDa while the more specific monoclonal antibody recognized antigens with approximate molecular weights of 80 kDa. The specificity of these two antibodies for T. canis and T. cati should prove helpful in the development of more specific assays for the diagnosis of visceral and ocular larva migrans.

  16. High Prevalence of Covert Infection With Gastrointestinal Helminths in Cats.

    PubMed

    Little, Susan; Adolph, Chris; Downie, Kathryn; Snider, Tim; Reichard, Mason

    2015-01-01

    Fecal flotation is routinely used to identify feline helminth infections in clinical practice, but it is known to have limitations of sensitivity, particularly for cestodes. To determine the prevalence of helminths in a contemporary population of cats and evaluate the ability of fecal flotation to detect these infections, helminths were recovered from intestinal tracts removed from 116 adult cats humanely euthanized by an animal control shelter in northeastern Oklahoma. Results were compared to those of fecal flotation performed using both passive and centrifugal techniques. Helminths were identified in 78/116 (67.2%) cats, including Toxocara cati (48/116; 41.4%), Ancylostoma tubaeforme (8/116; 6.9%), Dipylidium caninum (40/116; 34.5%), and Taenia taeniaeformis (30/116; 25.9%). Cats with T. cati were significantly more likely to harbor T. taeniaeformis (P = .001) than cats without ascarids. Centrifugal fecal flotation with sugar solution identified 37/48 (77.1%) T. cati infections, 8/30 (26.7%) T. taeniaeformis infections, and no D. caninum infections. Proglottids were detected on external examination in 19.0% (12/63) of cats with cestodes. Cestodes were present in over half of the cats examined in this study, but the majority of these infections were not evident by the detection of external proglottids or recovery of characteristic stages on fecal flotation.

  17. Collecting household water usage data: telephone questionnaire or diary?

    PubMed Central

    2009-01-01

    Background Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban non-potable (non-drinking) water use. The primary objective of this study was to compare household water usage results obtained using two data collection tools, a computer assisted telephone interview (CATI) and a 7-day water activity diary, in order to assess the effect of different methodological survey approaches on derived exposure estimates. Costs and logistical aspects of each data collection tool were also examined. Methods A total of 232 households in an Australian dual reticulation scheme (where households are supplied with two grades of water through separate pipe networks) were surveyed about their water usage using both a CATI and a 7-day diary. Householders were questioned about their use of recycled water for toilet flushing, garden watering and other outdoor activities. Householders were also questioned about their water use in the laundry. Agreement between reported CATI and diary water usage responses was assessed. Results Results of this study showed that the level of agreement between CATI and diary responses was greater for more frequent water-related activities except toilet flushing and for those activities where standard durations or settings were employed. In addition, this study showed that the unit cost of diary administration was greater than for the CATI, excluding consideration of the initial selection and recruitment steps. Conclusion This study showed that it is possible to successfully 'remotely' coordinate diary completion providing that adequate instructions are given and that diary recording forms are well designed. In addition, good diary return rates can be achieved using a monetary incentive and the diary format

  18. Collecting household water usage data: telephone questionnaire or diary?

    PubMed

    O'Toole, Joanne E; Sinclair, Martha I; Leder, Karin

    2009-11-09

    Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban non-potable (non-drinking) water use. The primary objective of this study was to compare household water usage results obtained using two data collection tools, a computer assisted telephone interview (CATI) and a 7-day water activity diary, in order to assess the effect of different methodological survey approaches on derived exposure estimates. Costs and logistical aspects of each data collection tool were also examined. A total of 232 households in an Australian dual reticulation scheme (where households are supplied with two grades of water through separate pipe networks) were surveyed about their water usage using both a CATI and a 7-day diary. Householders were questioned about their use of recycled water for toilet flushing, garden watering and other outdoor activities. Householders were also questioned about their water use in the laundry. Agreement between reported CATI and diary water usage responses was assessed. Results of this study showed that the level of agreement between CATI and diary responses was greater for more frequent water-related activities except toilet flushing and for those activities where standard durations or settings were employed. In addition, this study showed that the unit cost of diary administration was greater than for the CATI, excluding consideration of the initial selection and recruitment steps. This study showed that it is possible to successfully 'remotely' coordinate diary completion providing that adequate instructions are given and that diary recording forms are well designed. In addition, good diary return rates can be achieved using a monetary incentive and the diary format allows for collective recording, rather

  19. Fixed point theorems for generalized contractions in ordered metric spaces

    NASA Astrophysics Data System (ADS)

    O'Regan, Donal; Petrusel, Adrian

    2008-05-01

    The purpose of this paper is to present some fixed point results for self-generalized contractions in ordered metric spaces. Our results generalize and extend some recent results of A.C.M. Ran, M.C. Reurings [A.C.M. Ran, MEC. Reurings, A fixed point theorem in partially ordered sets and some applications to matrix equations, Proc. Amer. Math. Soc. 132 (2004) 1435-1443], J.J. Nieto, R. Rodríguez-López [J.J. Nieto, R. Rodríguez-López, Contractive mapping theorems in partially ordered sets and applications to ordinary differential equations, Order 22 (2005) 223-239; J.J. Nieto, R. Rodríguez-López, Existence and uniqueness of fixed points in partially ordered sets and applications to ordinary differential equations, Acta Math. Sin. (Engl. Ser.) 23 (2007) 2205-2212], J.J. Nieto, R.L. Pouso, R. Rodríguez-López [J.J. Nieto, R.L. Pouso, R. Rodríguez-López, Fixed point theorem theorems in ordered abstract sets, Proc. Amer. Math. Soc. 135 (2007) 2505-2517], A. Petrusel, I.A. Rus [A. Petrusel, I.A. Rus, Fixed point theorems in ordered L-spaces, Proc. Amer. Math. Soc. 134 (2006) 411-418] and R.P. Agarwal, M.A. El-Gebeily, D. O'Regan [R.P. Agarwal, M.A. El-Gebeily, D. O'Regan, Generalized contractions in partially ordered metric spaces, Appl. Anal., in press]. As applications, existence and uniqueness results for Fredholm and Volterra type integral equations are given.

  20. Theoretical Studies Relating to the Interaction of Radiation with Matter: Atomic Collision Processes Occurring in the Presence of Radiation Fields

    DTIC Science & Technology

    1981-09-01

    A24, Seprember (1981). 10. L.M. Humphrey, P.F. Liao and P.R. Berman, J. Opt. Soc. Amer. 70 1612 (1980). 11. See, for example, J.F. Lam, D.G. Steel, R.A...Rev. Letts. 46, 111 (1981). -7- PHYSICAL REVIEW A , VOLUME 23 , NUMBER 5 MAY 1981 Analytic solutions to the two-state problem for a class of...gen- 23 2496 0 1981 The American Physical Society Supported by the U.S. Office of Naval Research Reproduction in v.!:cle cr i, r’,1t is permitted

  1. Lagerungsabhängige Durchlässigkeit von Kies-/Sand- und Glaskugelfilterschüttungen

    NASA Astrophysics Data System (ADS)

    Nillert, Peter; Bachmann, Andreas; Nillert, David

    2015-06-01

    The hydraulic conductivity of loose and dense samples of commercially available filter grain material from natural gravels and sands has been estimated from permeameter test results and using the formula of Fair & Hatch (Jour. Amer. Water Works Assoc. 25:1551-1565, 1933). Sand and gravel with grain sizes of 0.4-9 mm and glass beads for water filters with particle sizes from 0.25 to 10 mm were examined. The formula is based on a sum calculated from the grain size analysis of the filter grain and its packing density, characterized by the porosity or void ratio specified for these materials.

  2. Numerical Studies of the Georgia Coast Sea Breeze

    DTIC Science & Technology

    1996-12-09

    measured the height and strength of the sea breeze from a manned hot-air balloon over Coney Island , New York for a two week period in July and August...Meteor., 34, 1739-1761. Sherman, 0. T., 1880: Observations on the height of land and sea breezes, taken at Coney Island . Amer. J. Sci., 119, 300-302. Staff...breeze front at each hour. SAV is Savannah; SVN is Hunter Army Airfield; SSI is Saint Simons Island ; NEA is Brunswick; and LIY is Ft Stewart. From W

  3. Walter Reed Army Institute of Research Annual Progress Report, Fiscal Year 1980

    DTIC Science & Technology

    1980-10-01

    Ul*$CTIV~i IUPINATIONS a. KINGOf AWRD 4 0 . CUbA. AMY. 0. 9 PAN "* Walter Reed kX-my Instittute of R.’search WI*Walter Reed Army Institute of Researci...for dogs was designed and tested. Cooperative cardiovascular studies are continuing. Andlysis of 2- PAN -Cl ~I Combo-Pens demonstrated the presence of the...technique to problems in the serologic diagnosis of plague. Bull. Pan Amer. Hlth. Organ. 13(4): 399- 402, 1979. 2. Williams, J.E., Moussa, M.A., and

  4. Economic Competitiveness in the Post Cold War Environment

    DTIC Science & Technology

    1991-03-18

    1990, p. 6. 56. Glazer, p. 128. 57. I-bid., p. 130. 58. Pearl M. Kamer, The U.S. Econormyin Crises, p. 108. 59. Ibid.., p. 1oo. 60. Daniel F. Burton and...W.ashkn t. ..__Po-S.t_, 7 October 1990, pp. H1-H5. Burton, Daniel F.; Gotbaum, Victor; and Rohatyn, Felix G. Vision For The 1990s. U.S.Stratyandq The...To Worse." The Economist, Vol. 317, 17 November 1990, pp. 25-26. Detorizos, Michael; Lester, Richard; and Solow , Robert. Made in Amer.,_Rgai ni i e

  5. Measured Effects of Square-Wave Modulated RF Fields (450 and 3100 MHz) on Cardiac Pacemakers

    DTIC Science & Technology

    1974-12-01

    population. Top row; Stimtech 3821; G.E. A2075A; Medcor 3-70A Middle row: Amer. Opt. 281003, and 281143; Biotronik IDP-44 Bottom row; Medtronic...American Optical Model 281143 (Predicta)--N3 effects were observed under all conditions tested. Biotronik Model IDP-44--This model pacemaker cut off at...tests. Three other models (the Biotronik model IDP-44, Cordis model 133C7, and G. E. model A2072D) demon- strated no serious effects at 200 V/m

  6. Attenuation of Blast Waves Using Foam and Other Materials

    DTIC Science & Technology

    1988-11-01

    details of the foam struc- 47511978).11D. T. Blackstock, "Nonlinear Acoustics (Theoretical)," Amer,. Imps. Phys.lure. Handbook , edited by D. E. Gray...depths less than 25 is, (PLP.)ds = 0.28 ( Arrl /ao) -0.04 (16) In order to compare this with the data presented in Re. [ 1 ] (as shown in Fig. 9) it was...B. M. Doaratz, LLNL Explosives Handbook , University of California, UCRL- 52997, 1981. 6. N. Lewis, Personal communication, U.S. Environmental Hygiene

  7. Hemoglobin-Based Blood Substitutes and Enhanced Susceptibility to Bacterial Infections

    DTIC Science & Technology

    1994-03-08

    Report for Grant No. DAMD17-91-Z-1009, Page 5 John R. Mahoney, Ph.D. adjuvant strains, in spite of having different 0, K and M serotypes, may possess a ...Bunn, H. (1993). The use of hemoglobin as a blood substitute. Amer. I. Hematol. 42 112-117. Conn, C., Franklin, B., Freter, R., & KIuger, M . (1991...Immunol 21_, 609-620. Vuopio-Varkila, J., Karvonen, M ., & Saxen , H. (1988). Protective capacity of antibodies to outer-membrane components of

  8. HST Observations of Saturnian Satellites during the 1995 Ring Plane Crossings

    NASA Astrophysics Data System (ADS)

    McGhee, Colleen A.; Nicholson, Philip D.; French, Richard G.; Hall, Katherine J.

    2001-08-01

    In May, August, and November 1995, Hubble Space Telescope (HST) observations during Saturn's ring-plane crossings allowed us to view saturnian satellites normally hidden to Earth-based observers in the glare of the rings. New measurements of Janus, Epimetheus, Prometheus, and Pandora have been combined to form revised orbital solutions using all three HST data sets. These measurements and orbit fits are presented, as well as similar fits for the brighter satellites Mimas, Tethys, Enceladus, Dione, and Rhea. Observations of the Lagrangian satellites Telesto, Calypso, and Helene are also reported. While most satellites were found to be close to their expected positions based on previous orbital solutions (Nicholson et al. 1992, Icarus100, 464-484; Jacobson 1996, Bull. Amer. Astron. Soc.28, 1185; and Harper and Taylor 1993, Astron. Astrophys. 268, 326-349). Prometheus lagged behind its predicted longitude by 18.85°±0.04°. A systematic drift in Pandora's longitude of -1.85° relative to the Voyager ephemeris was observed between May and November. The new data on the coorbital satellites Janus and Epimetheus have resulted in a revised mass for Janus, ˜6% smaller than the previous value (Jacobson 1995, Bull. Amer. Astron. Soc.27, 1202). Subtraction of light from the edge-on rings has led to additional detections of objects S/1995-S1 and S3 (Bosh and Rivkin 1995, Science272, 518-521) in the May data, and S/1995-S5, S6, S7 (Nicholson et al. 1995, Bull. Amer. Astron. Soc. 27, 1202) and S/1995-S9 (Roddier et al. 1996) in the August images. S1 is identified with Atlas but leads its predicted position by ˜25°. S3 has an orbit consistent with that of the narrow F ring, but S5, S6, S7, and S9 now appear to orbit ˜530-950 km interior to this ring. S7 and S9 may even be coorbital with Prometheus. An object in the May images, possibly corresponding to S7, is also found to lie very close to Prometheus' orbit (˜800 km interior to the F ring), but no convincing detections of

  9. Outpatient Benzodiazepine Prescribing, Adverse Events, and Costs

    DTIC Science & Technology

    2005-05-01

    accidental injury. Am J Public Health 1990 Dec;80(12):1467–70. 12. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic...review and meta- analysis: I psychotropic drugs. J Amer Geriatr Soc 1999 Jan;47(1):30–9. 13. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in...medication use in older adults: results of a U.S. consensus panel of experts. Arch Intern Med 2003 Dec 8– 22;163(22):2716–24. 23. Tinetti ME, Liu WL

  10. Thermal and Oxidation Response of UHTC Leading Edge Samples Exposed to Simulated Hypersonic Flight Conditions (Postprint)

    DTIC Science & Technology

    2013-03-01

    for reusable application. The UHTC sample was electro discharge machined from SPS ( Spark Plasma Sintering ) processed material of composition 20 vol...Silicon Carbide Produced by the Spark Plasma Sintering Method,” J. Amer. Ceram. Soc., 92 [9] 2046–52 (2009). 16D. D. Jayaseelan, H. Jackson, E. Eakins...SiC–HfB2, as described in Ref. 15 The SiC sample was sintered SiC (Hexaloy SE, St Gobain, Niagara Falls, NY) that was machined (diamond ground) by a

  11. Viscosity solutions of Isaacs' equations and differential games with Lipschitz controls

    NASA Astrophysics Data System (ADS)

    Barron, E. N.; Evans, L. C.; Jensen, R.

    It is demonstrated that the upper and lower values of a two-person, zero-sum differential game solve the respective upper and lower Isaacs' equations in the viscosity sense (introduced by Crandall and Lions ( Trans. Amer. Math. Soc. 277 (1983) , 1-42). Since such solutions are unique, this yields a fairly simple proof that the game has value should the minimax condition hold. As a further application of viscosity techniques, a new and simpler proof that the upper and lower values can be approximated by the values of certain games with Lipschitz controls is given.

  12. Calculation of Source and Strucutral Parameters at Regional and Teleseismic Distances

    DTIC Science & Technology

    1987-02-28

    Williams, L.A.J., 1972. Geology of the Eastern Rift System; Geol. Soc. of Amer. Spec. Paper #136, 67 p. Barker, J.S. & Langston, CA., 1981. Inversion of...Parameters, Regional Wave Propagation, Waveguide Scattering, T-Matrix. Upper Mantle Structure. Australia . India 1». ABSTRACT (Continu* on nttftrt« if...8hort-Period ^ *nd near-regional seismograms from l?t:L^ 5 ~A ) ^ar^uake3 located 1« Australia and India. When the effect of crusta

  13. Prevention of Single Event Upsets in Microelectronics

    DTIC Science & Technology

    1991-08-01

    by 1’. W. Williams, North-Holland, New York, NY, 1986. 14. E. J. McCluskey , "A Survey of Design for Testability Scan Techniques," VLSIDesign, vol. 5...Science, vol. NS-31, pp. 1453-1460, Dec. 1984. 18. W. V. Quine , "The Problem of Simplifying Truth Functions", Amer. Math. Monthly, vol. 59, No. 8, pp...expected time complexity is greatly reduced to a polynomial. The reduction of the boolean expressions are achieved by using Quine -McClusky algorithm

  14. Interdisciplinary Program for Quantitative Flaw Definition.

    DTIC Science & Technology

    1978-01-01

    difficult to work with, since they are mixed -boundary-value problems. SC595.32SA In this report an approximate method is developed, which is based on...geometry is shown in Fig. 2. The displacement components of the incident longitidunal wave are (ui) inc = Aopiexp [iw(xjpj/cL-t)] (6) where pi are the...Soc. Amer., forthcoming. Freund, L.B. (1972). Surface waves guided by a slit in an elastic solid, J. Appl . Mech., 39, 1027. Gautesen, A.K., J.D

  15. Computational Studies of Energetic Nitramines

    DTIC Science & Technology

    1991-09-11

    P. Sjoberg, J. S. Murray, T. Brinck , and P. Politzer, Can. J. Chem., 68, 1440 (1990). 34. J. S. Murray, P. Lane, T. Brinck , P. Politzer and P...S. Murray, Trans Amer. Cryst. Assoc. 26, in press. 44. J. S. Murray, T. Brinck , M. E. Grice and P. Politzer, J. Mol. Struct. (Theochem), in press...28 45. J. S. Murray, T. Brinck and P. Politzer, J. Mol. Struct. (Theochem), in press. 46. J. M. Seminario, J. S. Murray and P. Politzer, in The

  16. Predicting Warm Season Nocturnal Cloud-To-Ground Lightning Near Cape Canaveral, Florida

    DTIC Science & Technology

    2008-12-19

    coast to time and location of air-mass showers . J. Meteor ., 11, 507-511. Harms, D. E., B. F. Boyd, R. M. Lucci, M. S. Hinson, and M. W. Maier, 1997...Florida peninsula. J. Meteor ., 5, 275-280. Camp, J. P., A. I. Watson, and H. E. Fuelberg, 1998: The diurnal distribution of lightning over north Florida...Local Storms, Norman, Oklahoma, Amer. Meteor . Soc., 321-326. Doswell, C. A., III, and J. A. Flueck, 1989: Forecasting and verifying in a field

  17. Airport Activity Statistics of Certificated Route Air Carriers: Calendar Year 1989

    DTIC Science & Technology

    1989-01-01

    HARRISBURG/YORK, PA. J(HARRISBURG INTERNATIONAL) 0.10 9244 9387 9172 443954 5336.82 1188.83 HILO , HAWAII, HAWAII (GENERAL LYMAN FIELD) ................. 0.14...DURANGOA PLATA COUNTY) AP-ASPEN AIRW AYS AYS_ Domt...... S 31537 38.81 2.11 2.11 40.92 NS 73 AS 31610 38.81 2.11 2.11 40.92 HP-AMERIC N WEST...Domestic ............. .8080 HAWAII HILO ,HAWAII S 0.14 (GENERAL LYMAN FIELD) AQ-ALOHA AIRLINES ..................................... Domestic ...... S

  18. Compilation of Reprints Number 64.

    DTIC Science & Technology

    1987-11-01

    Transport in the New Z=land 1stauM boundary CAMnM a determined by the ncesity to cliewv the same presur in each lar at the northern end of the islands as... transport between Australia and South Americ which can only ecw through the Indooesian pasage The distnbution of this transport among layers is set in the...driven surface currents that can ,H = A + Q0 (3.2) be composed of both a nondivergent part giving rise where to horizontal transport and a divergent part

  19. Active Control of Radiated Sound with Integrated Piezoelectric Composite Structures. Volume 3: Appendices (Concl.)

    DTIC Science & Technology

    1998-11-06

    L. I. Nass, Encyclopedia ofPVC (2nd Edition V. 1, V. 2 dnd V. 3), M. Dekker, Inc., New York, 1986. [8] B . J . Lazan , Damping of Materials and Members...Piezoelectric, Double-Amplifier Active- Skin, Part I. Analytical," B . D. Johnson and C. R. Fuller, submitted to J . Acoust. Soc. of Amer.(1998) 27. "Broadband...Control of Plate Radiation Using a Piezoelectric, Double-Amplifier Active- Skin, Part tI. Experimental," B . D. Johnson and C. R. Fuller, submitted to J

  20. Nanoscale Imaging of Molecular Adsorption

    DTIC Science & Technology

    1994-06-20

    LiAI2(OH)6 ÷X-.nH20,21 and for synthetic HT-like phases.22 This ordered arrangement is most likely a consequence of coulombic interactions within the...hydroxy-2-methoxy-benzenesulfonic acid (MBSA) on the surface of HT. This compound is of technological interest because of its utility in cosmetics ...J. Amer. Chem. Soc., 115, 11521-11535 (1993). 9 Figure Captions Figure 1: (a) Hexagonal HT crystals adhered to a freshly cleaved mica substrate by

  1. Annual AFOSR Chemistry Program Review (19th)

    DTIC Science & Technology

    1974-01-01

    organomercury compounds. Through decomposition of C6HsHgCX 2 Cl (where X is chlorine, fluorine or bromine) he has obtained CX 2 intermediates which add...34Ground States of -bonded Molecules. XVII. Fluorine Compounds," M. J. S. Dewar and D. H. Lo, J. Amer. Chem. Soc., 94, 15, 5296 (1972). "Ground...B. T. Nakata, and J. D. Park, J. Fluorine Chem., 1, 235 (1971). "Free-Radical Reactions of Silanes with 1,2-Dihalopolyfluorocycloalkenes," J. D. Park

  2. Chemistry Within Molecular Clusters

    DTIC Science & Technology

    1992-06-01

    Hermann, V.; Kay, B. D.; Castleman , A. W., Jr.; Chem. Phys. 1982, 72, 185. (10) Stephan, K.; Futrell, J. H.; Peterson, K. I.; Castleman , A. W., Jr...Wagner, H. E.; Djuric, N.; Mark, T. D. Int. J. Mass Spectrom. Ion Phys. 1962, 44, 167. (11) Echt, 0.; Morgan, S.; Dao, P. D.; Stanley, R. J.; Castleman , A...J. Amer. Chem. Soc. 1973, 95, 7939. Morgan, S.; Castleman , A. W., Jr. J. Phys. Chem. 1989, 93, 4544. Ibid., J. Am. Chem. Soc., 1987, 109, 2868. (14

  3. The Capital Budgeting Policies of the U. S. Shipbuilding Industry: An Analysis of Defense Industry Behavior

    DTIC Science & Technology

    1979-10-01

    Johns - Manville ) and one whose net worth was comparable in 1976 (Cluett Peabody). • One company whose asset base was comparable to Lockheed’s in 1967...AVERAGE2 30.2 ’ KODAK ARMCO SFERRY RAND JOHNS - MANVILLE CLCETt PEABODY AMER.CYANAMID SINGER-1’ N.A. N.A. N.A. N.A. N.A. M.A. N.A. 9 11 10 22 4 13 N.A. 10...JIM WALTER 8 23 CUMMINS 58 8 MARTIN MARIETTA 9 90 SQUIBB 851 KOPPERS 708 UNION CAMP 624 INT’L MINING 68 2 JOHNS MANVILLE 814 EMERSON ELEC

  4. Bimanes (1,5-Diazabicyclo(3.3.0)Octadiendiones). Laser Activity in syn- Bimanes

    DTIC Science & Technology

    1990-05-24

    bimanes (1,5-diazwbicyclo[3.3.0]octadien- 2,8-diones) as laser dyes. Kosower introduced a system of trivial nomenclature for the bi- manes based on...and Properties. Background Information. Variation in substitution patterns in syn-bimanes has re- mained limited. In the Kosower scheme for their...Pavlopoulos and Joseph H. Boyer, U.S. 4,799,230(1989). [6.] E. M. Kosower and B. Pazhenchevsky, J. Amer. Chem. Soc., 102, 1980, 4983. [7.] E. M. Kosower , B

  5. Center of Excellence in Biotechnology (Research)

    DTIC Science & Technology

    1993-03-01

    Salpeter 1986-87 "Studies on the Role of Ascorbic Acid in Regulating Acetylcholine Receptor Synthesis in vitro" E. Racker 1986-88 "Stimulation of...34Acetylcholine Receptor ca- subunit mRNA is Increased by Ascorbic Acid in Cloned L5 Muscle Cells: Northern Blot Analysis and in sire Hybridization...Muscle Cells is Independent of Increases in Collagen Secretion Induced by Ascorbic Acid ", Amer. J. Clin. Nutr., 5-4, 1184S-1187S. A.B. Shapiro, K.D

  6. Study of Inhibitors of Neu and Related Tyrosine-Specific Protein Kinases: Implications for the Treatment of Breast Cancer.

    DTIC Science & Technology

    1998-09-01

    C, Lorenzo, M. J., Ponder, B. A. J., Mayer, B. J. and Cantley, L. C. Nature 1995, 373, 536-539. 6. Kwon, Y.-G., Srinivasan, J., Mendelow , M., Lee, T...R., Pluskey, S., Salerno, A., and Lawrence, D. S. /. Biol. Chem. 1993 268, 10713-10716. 31 7. Kwon, Y.-G., Mendelow , M., and Lawrence, D. S...J. Biol. Chem.1994 268, 4839-4844. 8. Lee, T. R., Mendelow , M., Srinivasan, J., Kwon, Y.-G., and Lawrence, D. S. J. Amer. Chem Soc. 1993 115, 9888

  7. The Shock and Vibration Digest. Volume 15. Number 2

    DTIC Science & Technology

    1983-02-01

    Propallar nolia, Nolia pradlctlon An axparlmantal itudy of tha wund field of K-icala ganaral aviation propallari hat baan complotad. Tha rawlti of than...of Social Survey Data on Noiae Effects F.L.Hall and S.M.Taylor McMaster Univ., Hamilton, Ontario, L8S 4K1, Cana- da, J. Acoust. Soc. Amer., 72 (4...significantly from the structural behavior predicted by added mass, or Incompressible, representations of the fluid. 83-341 IneUatk Cyclic Analysis of Pin

  8. Thin Film Models of SMSI (Show Strong Metal-Support Interactions) Catalysts: Pt on Oxidized Titanium.

    DTIC Science & Technology

    1983-10-17

    on single cyrstal SrTiO and for Ni/TiO 34 3 systems. (4 ) Our work is in good agreement with Huizinga (2 6 ) who finds no differences in reduced and...oxidized Pt/T102 powder systems by XPS. Huizinga suggests that the conclusions drawn in the Pt/SrTiO, and Ni/TiO2 work mentioned above are the result of...14. Belton, J.M. White and E.L. Hance, Chemn. Phys. Lett., 90,261(1982). 25. J.A. Horsely, J. Amer. Chemn. Soc., 110,2870(1979). 26. T. Huizinga

  9. Shigella flexneri Invasion Plasmid Antigens B and C: Epitope Location and Characterization with Monoclonal Antibodies

    DTIC Science & Technology

    1988-11-01

    Sti S4a7 I I I 24 ’Da lpaC product- S Sq Sq PP SgrOtl S 8 LI-Il a paC rroduc I6d1,0 6 S Sq Sq PP ;. gril 7 c5l 0a. paC productI I S g S agS PP ,gtI54W? I...acilitate the biochemical and f’unctional anal\\ sex of the I paB (LIane s t) (-labheled molecula 1.1xxIk e ight imarke rs iAmerIsh11a Corp. . and lpaC

  10. Some Open Problems in Random Matrix Theory and the Theory of Integrable Systems. II

    NASA Astrophysics Data System (ADS)

    Deift, Percy

    2017-03-01

    We describe a list of open problems in random matrix theory and the theory of integrable systems that was presented at the conference Asymptotics in Integrable Systems, Random Matrices and Random Processes and Universality, Centre de Recherches Mathématiques, Montréal, June 7-11, 2015. We also describe progress that has been made on problems in an earlier list presented by the author on the occasion of his 60^{th} birthday in 2005 (see [Deift P., Contemp. Math., Vol. 458, Amer. Math. Soc., Providence, RI, 2008, 419-430, arXiv:0712.0849]).

  11. Aerosol Direct Fluorination Synthesis: Alkyl Halides I, Neopentyl Chloride and Bromide, Free Radicals versus Carbocations.

    DTIC Science & Technology

    1983-07-30

    2. (a) R. D. Bagnall, W. Bell and K. Pearson, J. Fluor . Chem., 1977, 9, 359-375. (b) R. E. Banks, R. N. Haszeldine and Walton, J. Chem. Soc., 1963...c) T. Abe and S. Nagase, J. Fluor . Chem., 1979, 13, 519-530. 4. M. Schmeisser, K. P. Ehlers and P. Sartori, Angew. Chem. (Int. Ed.), 1967, V 6, 627...Bollinger, J. Amer. Chem. Soc., 1968, 90, 947-53. 12. M. H. Habibi and L. C. Sams, J. Fluor . Chem., 1981, 18, 277-280. 13. Sadtler, Infrared #41640P

  12. 100 Companies Receiving the Largest Dollar Volume of Prime Contract Awards, Fiscal Year 1983

    DTIC Science & Technology

    1983-01-01

    CORP 84. NI INDUSTRIES 99. CUBIC CORP 53. NORTH AMER!CAN PHILIPS CORP 100. DIGITAL EOUIPMENT CORP 26. NORTHROP CORP 83. DUCHOSSOIS THRAL. GROUP INC 58...RESEARCH + ENGINEERING CO 40 RELIANCE ELECTRIC CO 1,484 TOTAL 874,215 0.68 50.57 26. NORTHROP CORP 729,741 NORTHROP SERVICES INC 8,086 NORTHROP WORLDWIDE...WHEELABRATOR FRYE 1,263 TOTAL 342,310 0.27 61.27 51. ROYAL DUTCH SHELL GROUP SHELL CHEMICAL INC 363 SHELL EASTERN PETROLEUM PTE LTC 120,140 SHELL

  13. The Effects Of Soldiers’ Loads on Postural Sway

    DTIC Science & Technology

    2004-12-01

    pack design and to develop exercise programs that improve Soldiers’ balance ( Tinetti et al., 1994). To maintain balance when standing and to avoid a...measure, we averaged the data across a volunteer’s ten trials under a condition to obtain a single score on each measure for each load condition...postural stability, heart rate, and perceived exertion, Amer. Ind. Hyg. Assoc. J., 52(10), 417-422. Tinetti , M.E., Baker, D.I., McAvay, G., Claus

  14. Syncom 4 deploy, LDEF retrieval highlight 10-day Columbia flight

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The objectives of Space Shuttle Mission STS-32 are described along with major flight activities, prelaunch and launch operations, trajectory sequence of events, and landing and post-landing operations. The primary objectives of STS-32 are the deployment of a Navy synchronous communications satellite (Syncom 4) and the retrieval of the Long Duration Exposure Facility (LDEF) launched from the Challenger in April 1984. Secondary STS-32 payloads include a protein crystal growth experiment, the Fluids Experiment Apparatus (FEA) for the investigation of microgravity materials processing, the Mesoscale Lighting Experiment, the Latitude-Longitude Locator Experiment, the Americal Flight Echocardiograph, and an experiment to investigate neurospora circadian rhythms in a microgravity environment.

  15. Hostile Coexistence: The Chinese Challenge to the United States

    DTIC Science & Technology

    1966-04-08

    naval and air power in the Western PaCi t iL, e quipped wi L m niclear weapons, could infl ict sc riol s dama ,ge on our strategic and induistriala...inglJuencetd are worketrs, stual,s, revoluitioina ry intl bcp- tnaIs, and certain minority groups, Irtitnlarly the negroes . As Cha irnan Mao recent ly tited...till it , t, Oppost, Racial Discrininat ion by tS Iiperiali,sm and Support t ie Americal NegrOes in TIlL’i r S t ruggIc Against Racia I Discriminat in

  16. Application of Gene Expression Analysis with Microarrays and Proteomics to the Problem of Hemorrhagic Shock and Resuscitation

    DTIC Science & Technology

    2004-09-01

    Care Medicine 1995; 23(8): 1319-26. 9. Shenkar R, Cohen AJ, Vestweber D, Miller YE, Tuder R, Abraham E: Hemorrhage and resuscitation alter the...expression of ICAM-1 and P-selectin in mice. J Inflamm 1995; 45(4): 248-59. 10. Shenkar R, Schwartz MD, Terada LS, Repine JE, Mccord J, Abraham E...Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo. Amer J Physiol-Lung Cell M Ph 1996; 14(5): L729-L735. 11. Shenkar R, Abraham E

  17. A Comparison of Radar Rainfall Estimates and Rain Gage Measurements during Two Denver Thunderstorms

    DTIC Science & Technology

    1992-01-01

    hail. J. Climate AppL. Meteor., 25, 1956-1958 Larson, L.W., and E.L. Peck, 1974: Accuracy of precipitation measurments and hydrologic modeling . Water...Conference on: Radar Meteorology, Amer. Meteor. Soc., 569-574. NEXRAD, 1982: NEXRAD technical requirements (NTR). NEXRAD Joint System Program Office...at gage 1720 were certainly significant for such a short time period. 64 -- I I I 8. *0 • Figure 5.1a. 8 8 Figure 5. 1. Ranal (m.o 6510 D eemndfo

  18. Model of High-Energy-Density Battery Based on SiC Schottky Diodes

    DTIC Science & Technology

    2006-10-01

    ARL -D J M MILLER ATTN AMSRD- ARL -CI-OK-T TECHL PUB (2 COPIES ) ATTN AMSRD- ARL -CI-OK-TL TECHL LIB (2 COPIES) ATTN AMSRD- ARL -SE-DE M LITZ ...Model of High-Energy-Density Battery Based on SiC Schottky Diodes by Yves Ngu, Marc Litz , and Bruce Geil ARL -TR-3981 Ocotber 2006...Spectrum September 2004, 36-41. 6. Litz , M .; et al. On-Demand High Energy Density Materials. Amer. Inst. of Aero. and Astro. 7. Litz , M

  19. A Comparison of Microstructure and Properties of Equivalent Strength Ingot Metallurgy and Powder Metallurgy 7XXX Aluminum Alloys.

    DTIC Science & Technology

    1981-08-01

    conjunction with other corrosion susceptibility evaluations. Rockwell B hardness testing was performed in accordance with ASTM Standard E18 -74 (Reference 286...M-T6 89 I/M-T73 85 P/M-T6 88 P/M-T73 84 (average of five tests) * ASTM E18 -74 TABLE 16 CONDUCTIVITY* DATA Material % IACS I/M-T6 32 I/M-T73 37 P/M-T6...282. 6. Dieter, op. cit., 409. 283. D. Voss, op. cit., 83. 284. W. Neenning, Int’l J. of Fract., 11, (1), (1975), 123. 286. ASTM STD E18 -74. Amer. Soc

  20. Effect of Contact Damage on the Strength of Ceramic Materials.

    DTIC Science & Technology

    1983-10-01

    RITT’ER, in I. Amer. Ceram. Soc. in press. "’Fracture Mechanics Applied to Brittle Materials", 7. D. B. MARSHALL and B. R. LAWN, A. Mater. Sci. ASTM ...Special Technical Publication 678, edited by 14 (1979) 2001. S. W. Freimian ( ASTM , Philadelphia, 1979) p. 202. 8. D. B. MARSHALL. B. R. LAWN and P. CHANTi...reducing the crack 37 size to the scale of the deformation zone E17] or of the microstructure E18 ). Systematic variations in the load dependence of

  1. The GRM7 gene, early response to risperidone, and schizophrenia: a genome-wide association study and a confirmatory pharmacogenetic analysis.

    PubMed

    Sacchetti, E; Magri, C; Minelli, A; Valsecchi, P; Traversa, M; Calza, S; Vita, A; Gennarelli, M

    2017-03-01

    The search for biomarkers of response to antipsychotic medications is hindered by difficulties inherent in the topic or related to persistent methodological difficulties, such as high rates of anticipated discontinuation and consequent distortions in the imputation of missing data. Because early response to antipsychotics represents a sufficiently reliable index of the subsequent treatment response in patients with schizophrenia, we undertook a real-world, genome-wide association study (GWAS) with the aim of identifying genetic predictors of response to risperidone after 2 weeks in 86 patients with schizophrenia. Limited to the associations reaching significance in the GWAS, confirmatory analysis relative to risperidone response over 9 months was also designed involving 97 patients (European only) enroled in the CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) genetic substudy. The GWAS revealed a significant association (false discovery rate 0.02) of the single-nucleotide polymorphism rs2133450 inside the GRM7 gene with Emsley's positive domain derived from the positive and negative syndrome scale (PANSS). Patients with the rs2133450 CC genotype presented poorer improvement in the positive domain over 2 weeks, with odds ratios of 12.68 (95% CI, 3.51-45.76) and 6.95 (95% confidence interval (CI), 2.37-20.37) compared with patients with the AA and AC genotypes, respectively. Compared with A homozygotes, rs2133450 C homozygotes enroled in the CATIE-derived confirmatory analysis showed less improvement in Emsley's positive, excited and depression domains, positive and general PANSS subtypes, and total PANSS after 9 months of treatment with risperidone. The original GWAS and the CATIE-derived confirmatory analysis support the proposal that the rs2133450 may have translational relevance as a predictor of response to risperidone.

  2. Parasite communities in stray cat populations from Lisbon, Portugal.

    PubMed

    Waap, H; Gomes, J; Nunes, T

    2014-12-01

    Stray cats live in high-density colonies in urban areas and pose a health hazard to household cats and humans. In Portugal, information on the parasitic fauna of stray cats is limited and relies mostly on results from faecal analysis. The present survey aimed to determine the prevalence, diversity and intensity of parasites in stray cats from the urban area of Lisbon by means of parasitological necropsy. Internal organs were collected from 162 cats captured in different areas of the city and systematically subjected to parasitological dissection. Helminths were identified by macro- and microscopic examination and protozoa by faecal floatation and sedimentation techniques. The overall prevalence of parasites was 90.7% (95% confidence interval (CI): 85.3-94.6%). A total of 12 parasite species was recorded: Cystoisospora felis (14.2%), Cystoisospora rivolta (46.3%), Sarcocystis sp. (1.2%), Ancylostoma tubaeforme (19.1%), Toxocara cati (38.3%), Ollulanus tricuspis (30.9%), Aelurostrongylus abstrusus (12.4%), Eucoleus aerophilus (0.6%), Taenia taeniaeformis (3.1%), Dipylidium caninum (53.1%), Joyeuxiella pasqualei (15.4%) and Diplopylidium nölleri (3.7%). Overall mean species richness was 2.36 ±  1.52. Helminth mean intensity was highest for O. tricuspis (285.8), followed by D. caninum (42.4), J. pasqualei (14.4), A. tubaeforme (8.1) and T. cati (5.9). The prevalence and variety of parasites found in our sampling are substantially higher than the numbers previously reported in Portugal. Some of the parasites, including T. cati and A. tubaeforme, are zoonotic, which emphasizes the need for parasite control strategies based on demographic containment of stray cat populations in urban areas to promote public health protection.

  3. Social encounter profiles of greater Melbourne residents, by location--a telephone survey.

    PubMed

    Rolls, David A; Geard, Nicholas L; Warr, Deborah J; Nathan, Paula M; Robins, Garry L; Pattison, Philippa E; McCaw, James M; McVernon, Jodie

    2015-11-02

    Models of infectious disease increasingly seek to incorporate heterogeneity of social interactions to more accurately characterise disease spread. We measured attributes of social encounters in two areas of Greater Melbourne, using a telephone survey. A market research company conducted computer assisted telephone interviews (CATIs) of residents of the Boroondara and Hume local government areas (LGAs), which differ markedly in ethnic composition, age distribution and household socioeconomic status. Survey items included household demographic and socio-economic characteristics, locations visited during the preceding day, and social encounters involving two-way conversation or physical contact. Descriptive summary measures were reported and compared using weight adjusted Wald tests of group means. The overall response rate was 37.6%, higher in Boroondara [n = 650, (46%)] than Hume [n = 657 (32%)]. Survey conduct through the CATI format was challenging, with implications for representativeness and data quality. Marked heterogeneity of encounter profiles was observed across age groups and locations. Household settings afforded greatest opportunity for prolonged close contact, particularly between women and children. Young and middle-aged men reported more age-assortative mixing, often with non-household members. Preliminary comparisons between LGAs suggested that mixing occurred in different settings. In addition, gender differences in mixing with household and non-household members, including strangers, were observed by area. Survey administration by CATI was challenging, but rich data were obtained, revealing marked heterogeneity of social behaviour. Marked dissimilarities in patterns of prolonged close mixing were demonstrated by gender. In addition, preliminary observations of between-area differences in socialisation warrant further evaluation.

  4. Gastrointestinal Helminths and Ectoparasites in the Stray Cats (Felidae: Felis catus) of Ahar Municipality, Northwestern Iran.

    PubMed

    Yakhchali, Mohammad; Hajipour, Nasser; Malekzadeh-Viayeh, Reza; Esmaeilnejad, Bijan; Nemati-Haravani, Taher; Fathollahzadeh, Mohammad; Jafari, Rasool

    2017-01-01

    The stray cats are considered as the sources of emerging humans and domestic livestock pathogens and the zoonoses of public health importance. The present study was aimed to elucidate intestinal helminth infections and infestation with ectoparasites of the stray cats of Ahar City, northwestern Iran. Totally, 51 stray cats were randomly trapped from different parts of the city between Mar and Nov 2013. The cats were assessed for ectoparasites by hair brushing, skin scraping, acetate tape preparation and othic swabs. They were euthanized and inspected for helminths infection. Overall prevalence of helminths and flea were 44/51 (86.3%) and 31/51 (60.78%), respectively. The infection rates were significantly different among different age groups (P<0.05). Of the 282 isolated helminths, three species of nematodes (Toxocara cati (86.3%), T. leonina (11.77%), Ancylostoma tubaeforme (5.9%)) and four species of cestodes (Taenia taeniaeformis (64.7%), Mesocestoides lineatus (49.02%), Dipylidium caninum (29.41%), T. hydatigena (19.6%)) were identified. The predominant infectious helminths in all the infected cats were T. cati (86.3% with egg per gram of feces 27.75±9). Of the 270 collected fleas, two species of Ctenocephalides felis (80%) and C. canis (20%) were notably frequent in the cats aged 2-3-year-old. The average number of fleas per each infected cat was recorded as 5.29, with no incidence of cross-infection. The results indicated the high rate of helminths infections and flea infestation in the urban stray cats of which Toxocara cati and Ctenocephalides felis may play important roles as zoonotic agents in the region.

  5. Effect of Second Generation Antipsychotics on Caregiver Burden in Alzheimer Disease

    PubMed Central

    Mohamed, Somaia; Rosenheck, Robert; Lyketsos, Constantine G.; Kaczyinski, Richard; Sultzer, David; Schneider, Lon S.

    2014-01-01

    Context Alzheimer disease (AD) imposes a severe burden upon patients and their caregivers. Severity of psychiatric symptoms and behavioral disturbances are important determinants of caregivers’ experience of burden. These symptoms may be improved with atypical antipsychotic treatment. Objective In this study we use data from the CATIE-AD trial to evaluate the effect of atypical antipsychotics as compared to placebo on the experiences of caregivers of outpatients with Alzheimer disease. Design We compared the effect of atypical antipsychotic drugs (olanzapine, risperidone or quetiapine) considered together as a group, to placebo, on experiences of caregivers of AD outpatients. We also evaluated whether improvement in patients’ psychiatric and behavioral symptoms mediated the relationship between drug treatment and caregiver burden. Setting CATIE-AD included outpatients in usual care settings, and assessed treatment effectiveness over a nine-month period. Participants Data from CATIE-AD participants who had at least one post-baseline outcome assessment, and from their caregivers, were examined in an intention-to-treat analysis (ITT) (N=361), and then in a phase 1 only analysis including only observations while on the initially randomized drug (N=153). Measures The Burden Interview, Beck Depression Inventory, and the NPI Caregiver Distress Scale were used to evaluate caregiver burden. Results In both ITT and phase 1-only analyses, caregivers of patients treated with second generation antipsychotics (SGAs) scored significantly lower than those on placebo on both the Burden Interview (p = 0.009) and the NPI Caregiver Distress Scale’s scores (p = 0.0209). These differences appeared to have been mediated by lower levels of agitation, hostility, and psychotic distortions. Conclusion In AD patients with symptoms of psychosis, agitation or aggressive behavior, medications can have a small but significant impact on caregiver burden. PMID:21939611

  6. Evaluation of Mechanisms to Improve Performance of Mobile Phone Surveys in Low- and Middle-Income Countries: Research Protocol.

    PubMed

    Gibson, Dustin G; Pariyo, George William; Wosu, Adaeze C; Greenleaf, Abigail R; Ali, Joseph; Ahmed, Saifuddin; Labrique, Alain B; Islam, Khaleda; Masanja, Honorati; Rutebemberwa, Elizeus; Hyder, Adnan A

    2017-05-05

    Mobile phone ownership and access have increased rapidly across low- and middle-income countries (LMICs) within the last decade. Concomitantly, LMICs are experiencing demographic and epidemiologic transitions, where non-communicable diseases (NCDs) are increasingly becoming leading causes of morbidity and mortality. Mobile phone surveys could aid data collection for prevention and control of these NCDs but limited evidence of their feasibility exists. The objective of this paper is to describe a series of sub-studies aimed at optimizing the delivery of interactive voice response (IVR) and computer-assisted telephone interviews (CATI) for NCD risk factor data collection in LMICs. These sub-studies are designed to assess the effect of factors such as airtime incentive timing, amount, and structure, survey introduction characteristics, different sampling frames, and survey modality on key survey metrics, such as survey response, completion, and attrition rates. In a series of sub-studies, participants will be randomly assigned to receive different airtime incentive amounts (eg, 10 minutes of airtime versus 20 minutes of airtime), different incentive delivery timings (airtime delivered before survey begins versus delivery upon completion of survey), different survey introductions (informational versus motivational), different narrative voices (male versus female), and different sampling frames (random digit dialing versus mobile network operator-provided numbers) to examine which study arms will yield the highest response and completion rates. Furthermore, response and completion rates and the inter-modal reliability of the IVR and CATI delivery methods will be compared. Research activities are expected to be completed in Bangladesh, Tanzania, and Uganda in 2017. This is one of the first studies to examine the feasibility of using IVR and CATI for systematic collection of NCD risk factor information in LMICs. Our findings will inform the future design and

  7. Evaluation of Mechanisms to Improve Performance of Mobile Phone Surveys in Low- and Middle-Income Countries: Research Protocol

    PubMed Central

    Wosu, Adaeze C; Greenleaf, Abigail R; Ali, Joseph; Ahmed, Saifuddin; Labrique, Alain B; Islam, Khaleda; Masanja, Honorati; Rutebemberwa, Elizeus; Hyder, Adnan A

    2017-01-01

    Background Mobile phone ownership and access have increased rapidly across low- and middle-income countries (LMICs) within the last decade. Concomitantly, LMICs are experiencing demographic and epidemiologic transitions, where non-communicable diseases (NCDs) are increasingly becoming leading causes of morbidity and mortality. Mobile phone surveys could aid data collection for prevention and control of these NCDs but limited evidence of their feasibility exists. Objective The objective of this paper is to describe a series of sub-studies aimed at optimizing the delivery of interactive voice response (IVR) and computer-assisted telephone interviews (CATI) for NCD risk factor data collection in LMICs. These sub-studies are designed to assess the effect of factors such as airtime incentive timing, amount, and structure, survey introduction characteristics, different sampling frames, and survey modality on key survey metrics, such as survey response, completion, and attrition rates. Methods In a series of sub-studies, participants will be randomly assigned to receive different airtime incentive amounts (eg, 10 minutes of airtime versus 20 minutes of airtime), different incentive delivery timings (airtime delivered before survey begins versus delivery upon completion of survey), different survey introductions (informational versus motivational), different narrative voices (male versus female), and different sampling frames (random digit dialing versus mobile network operator-provided numbers) to examine which study arms will yield the highest response and completion rates. Furthermore, response and completion rates and the inter-modal reliability of the IVR and CATI delivery methods will be compared. Results Research activities are expected to be completed in Bangladesh, Tanzania, and Uganda in 2017. Conclusions This is one of the first studies to examine the feasibility of using IVR and CATI for systematic collection of NCD risk factor information in LMICs. Our

  8. Gastrointestinal Helminths and Ectoparasites in the Stray Cats (Felidae: Felis catus) of Ahar Municipality, Northwestern Iran

    PubMed Central

    YAKHCHALI, Mohammad; HAJIPOUR, Nasser; MALEKZADEH-VIAYEH, Reza; ESMAEILNEJAD, Bijan; NEMATI-HARAVANI, Taher; FATHOLLAHZADEH, Mohammad; JAFARI, Rasool

    2017-01-01

    Background: The stray cats are considered as the sources of emerging humans and domestic livestock pathogens and the zoonoses of public health importance. The present study was aimed to elucidate intestinal helminth infections and infestation with ectoparasites of the stray cats of Ahar City, northwestern Iran. Methods: Totally, 51 stray cats were randomly trapped from different parts of the city between Mar and Nov 2013. The cats were assessed for ectoparasites by hair brushing, skin scraping, acetate tape preparation and othic swabs. They were euthanized and inspected for helminths infection. Results: Overall prevalence of helminths and flea were 44/51 (86.3%) and 31/51 (60.78%), respectively. The infection rates were significantly different among different age groups (P<0.05). Of the 282 isolated helminths, three species of nematodes (Toxocara cati (86.3%), T. leonina (11.77%), Ancylostoma tubaeforme (5.9%)) and four species of cestodes (Taenia taeniaeformis (64.7%), Mesocestoides lineatus (49.02%), Dipylidium caninum (29.41%), T. hydatigena (19.6%)) were identified. The predominant infectious helminths in all the infected cats were T. cati (86.3% with egg per gram of feces 27.75±9). Of the 270 collected fleas, two species of Ctenocephalides felis (80%) and C. canis (20%) were notably frequent in the cats aged 2-3-year-old. The average number of fleas per each infected cat was recorded as 5.29, with no incidence of cross-infection. Conclusion: The results indicated the high rate of helminths infections and flea infestation in the urban stray cats of which Toxocara cati and Ctenocephalides felis may play important roles as zoonotic agents in the region. PMID:28761492

  9. Ascarid infections of cats and dogs.

    PubMed

    Parsons, J C

    1987-11-01

    The ascarids Toxocara canis, Toxocara cati, and Toxascaris leonina are probably the most common gastrointestinal helminths encountered in small animal practice. Both T. canis and T. cati can cause serious disease in kittens and puppies; T. leonina is generally less pathogenic. Prenatal transmission assures that virtually all puppies are born infected with T. canis. Transmammary transmission is probably the major route of infection for kittens with T. cati. In addition, all three species of worm produce resistant eggs and use paratenic hosts to facilitate transmission. Much is now known about the complex biology and life history of T. canis. However, many questions, such as those concerning the mechanisms of larval survival within host tissues and of larval reactivation and migration during pregnancy, await further study. The mechanism of resistance to ascarid infections in cats and dogs has not been clearly defined. Ascariasis is traditionally thought to be a disease of young animals, with older animals being considered immune. However, at least in the case of T. canis, adult dogs can be repeatedly infected. A wide range of anthelmintics is available with extremely high efficacy against patent ascarid infections. The problem of prenatal infection with T. canis may be overcome by strategic use of the newer benzimidazole-carbamates, and the production of ascarid-free puppies now seems possible. However, complete larvicidal activity against somatic stages has not been convincingly demonstrated. Visceral larva migrans-like syndromes are now being recognized in dogs and cats. In addition, visceral larva migrans in children due to T. canis continues to be a significant zoonotic disease in North America and underscores the need for the veterinary profession to control ascarid infections in cats and dogs at every opportunity.

  10. Eosinophilic pneumonia due to toxocariasis: an adult case report.

    PubMed

    Demirci, Mustafa; Unlü, Mehmet; Fidan, Fatma; Kaya, Selçuk

    2012-01-01

    Toxocara is a roundworm, a common parasite of dogs (T. canis) and cats (T. cati). Toxocariasis or Visceral larva migrans (VLM) are diseases caused by the larvae of Toxocara sp., which may involve many organs, but pulmonary symptoms such as coughing and wheezing and allergic symptoms are seen in more than 80% of patients. It is known that, although the risk of infection is present, the worldwide diagnosis of toxocariasis is difficult since clinical and laboratory data provide insufficient evidence for the diagnosis. Nowadays, the diagnosis of toxocariasis is performed by serologic methods. We describe herein a case of toxocariasis with eosinophilic pneumonia that was diagnosed using serologic methods.

  11. Toxocariasis of the central nervous system: With report of two cases.

    PubMed

    Abir, Bouthouri; Malek, Mansour; Ridha, Mrissa

    2017-03-01

    Toxocariasis is a parasitic infection caused by the roundworms Toxocara canis or Toxocara cati, mostly due to accidental ingestion of embryonated eggs. Clinical manifestations vary and are classified according to the organs affected. Central nervous system involvement is an unusual complication. Here, we report two cases with neurological manifestations, in which there was cerebrospinal fluid (CSF) eosinophilia with marked blood eosinophilia and a positive serology for Toxocara both in serum and CSF. Improvement of signs and symptoms after specific treatment was observed in the two cases.

  12. Pulmonary toxocariasis: a case report and literature review.

    PubMed

    Ranasuriya, G; Mian, A; Boujaoude, Z; Tsigrelis, C

    2014-06-01

    Toxocariasis is a parasitic disease caused by Toxocara canis or T. cati. We report a patient with toxocariasis who presented with dyspnea, high-grade eosinophilia, and bilateral pulmonary nodules. To further characterize the pulmonary manifestations of toxocariasis, we have reviewed 11 previously published pulmonary toxocariasis cases. The most common pulmonary symptoms in our review were cough and dyspnea, and the most common finding on chest imaging was bilateral pulmonary nodules. Risk factors for Toxocara infection primarily included exposure to dogs. Most patients received albendazole and responded well. A high index of suspicion is needed to diagnose this otherwise preventable parasitic disease.

  13. Kassite from the Diamond Jo quarry, Magnet Cove, Hot Spring County, Arkansas: the problem of cafetite and kassite.

    USGS Publications Warehouse

    Evans, H.T.; Dwornik, E.J.; Milton, C.

    1986-01-01

    Small (<0.5 mm), brownish-pink platy rosettes and yellow spherules, in cavities in nepheline syenite at the Diamond Jo quarry, Magnet Cove, have been identified as kassite, CaTi2O4(OH)2, a mineral previously known only from the Kola Peninsula, USSR. The X-ray powder and single-crystal data and density of the Magnet Cove kassite correspond with those reported by earlier workers for cafetite, (Ca,Mg)(Fe,Al)2Ti4O12.4H2O, from Kola, but the chemical and physical properties correspond with those given in their description of kassite.-J.A.Z.

  14. Operation RANGER, Shots ABLE, BAKER, EASY, BAKER-2, FOX, 25 January-6 February 1951

    DTIC Science & Technology

    1982-02-26

    not instrumented A = Instrumented with film packets * = Instrumented with gold-foil neutron detector t - Isnummnted wth Victoen bakel thimble ion...03-423-00 7. AUTHOR(*) S. CONTRACT OR GRANT NUMSER( a ) Carl Haag, Stephen Rohrer, Robert Shepanek DNA 001-79-C-0473 S. P"-ORMING ORGANIZATION NAME AND...20305 182 IA. MONITORING AGEN•CY NAMt & ADDRESS(hI differnt f Canrolling Offce.) 15. SECURITY CL %SS. (of ths report) UNCLASSIFIED 1I5. DECL A $F1 CATI ON

  15. Mobile Phone Surveys for Collecting Population-Level Estimates in Low- and Middle-Income Countries: A Literature Review.

    PubMed

    Gibson, Dustin G; Pereira, Amanda; Farrenkopf, Brooke A; Labrique, Alain B; Pariyo, George W; Hyder, Adnan A

    2017-05-05

    National and subnational level surveys are important for monitoring disease burden, prioritizing resource allocation, and evaluating public health policies. As mobile phone access and ownership become more common globally, mobile phone surveys (MPSs) offer an opportunity to supplement traditional public health household surveys. The objective of this study was to systematically review the current landscape of MPSs to collect population-level estimates in low- and middle-income countries (LMICs). Primary and gray literature from 7 online databases were systematically searched for studies that deployed MPSs to collect population-level estimates. Titles and abstracts were screened on primary inclusion and exclusion criteria by two research assistants. Articles that met primary screening requirements were read in full and screened for secondary eligibility criteria. Articles included in review were grouped into the following three categories by their survey modality: (1) interactive voice response (IVR), (2) short message service (SMS), and (3) human operator or computer-assisted telephone interviews (CATI). Data were abstracted by two research assistants. The conduct and reporting of the review conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A total of 6625 articles were identified through the literature review. Overall, 11 articles were identified that contained 19 MPS (CATI, IVR, or SMS) surveys to collect population-level estimates across a range of topics. MPSs were used in Latin America (n=8), the Middle East (n=1), South Asia (n=2), and sub-Saharan Africa (n=8). Nine articles presented results for 10 CATI surveys (10/19, 53%). Two articles discussed the findings of 6 IVR surveys (6/19, 32%). Three SMS surveys were identified from 2 articles (3/19, 16%). Approximately 63% (12/19) of MPS were delivered to mobile phone numbers collected from previously administered household surveys. The majority of MPS (11

  16. McGhee-Tyson ANGB, Knoxville, Tennessee. Revised Uniform Summary of Surface Weather Obserations (RUSSWO). Parts A-F.

    DTIC Science & Technology

    1988-03-01

    8217JOURLY OBStavATIONIs OCT 7? - SEP Si SUMMARY OF OAT DATA: JAN 44 - SEP 07 TIME CON VERSION LST TO GMT: -5 Ave 1. 1 t~ CATI[ PRODUCED. OS NAP lose~lv.1 4F... TIME IRIUPSt IN ALL SUMMARIES SHOWING OIURNAL VARIATIONS, WE SUMMARIZE DATA USING TIE FOLLOWING EIGT S-FUR TIME PERIODS IN LOCAL STANDARD TIME : 0000...Tit STANDARD 3-4OUR TIME GROUPS BY MONTH. MONTS-LY AND ANNUALLY (ALL YEARS COMBINED). ATMOSP-RIC PPENOMENA SUMMARY 1. A PERCENTAGE FREQUENCY OF DAYS

  17. Does NATO Weaken the West.

    DTIC Science & Technology

    1988-04-01

    x:,... can see, _v’vl r-ped two right • :] definitions , eter,,.- . The U.S. saw detent- as_ bringing the Soviet Union "into the comm.r it, ,.-f...line in ideology, in Eastern Europe .. " more eco:om ic minded leaders in the East, and the Soviet Union easing their 1iht reign on the East to the...cati ni i :i .j - ) rl I.ets. (7:50-5<: Also, t-,e Europea n view of ’-he pipeline em-tui-go i_.: .it is harder for- ;nroF.en-r, than f :nr the ’hittd i

  18. Frobisher Bay, Baffin Island, Northwest Territories, Canada. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    DTIC Science & Technology

    1970-01-29

    to the National Technical Information Service (NTIS). This technical report has been reviewed and is aonroved for ouhl i cati on. WAYNE IMCOLLOM,h...ADDRESS 12 REPORT ::ATE U 29 JAN 70 Air Weather Service (MAC) 13 1 6 S6ER OF PA2ES Scott AFB IL 62225 14 .ONITORIN2. AGENCY NAUME 8 ADDRESS(,e .I,fl- I...N/A N/A N/A to Aug 50 USAF ITAC JMA I4 0-64A (OL.) MAC- Al It .- li, PAT ROCSI G DIVISION Revised ETAC/USAF AIR WEATIE SERVICE (MAC) UNIFORM SUMMARY

  19. The Reliability of a Computer-Assisted Telephone Interview Version of the Ohio State University Traumatic Brain Injury Identification Method.

    PubMed

    Cuthbert, Jeffrey P; Whiteneck, Gale G; Corrigan, John D; Bogner, Jennifer

    2016-01-01

    Provide test-retest reliability (>5 months) of the Ohio State University Traumatic Brain Injury Identification Method modified for use as a computer-assisted telephone interview (CATI) to capture traumatic brain injury (TBI) and other substantial bodily injuries among a representative sample of noninstitutionalized adults living in Colorado. Four subsamples of 50 individuals, including people with no major lifetime injury, a major lifetime injury but no TBI, TBI with no loss of consciousness, and TBI with loss of consciousness, were interviewed using the CATI Ohio State University Traumatic Brain Injury Identification Method between 6 and 18 months after an initial interview. Stratified random sample of Coloradans (n = 200) selected from a larger study of TBI. Cumulative, Severity and Age-related indices were assessed for long-term reliability. Cumulative indices were those that summed the total number of specific TBI severities across the lifetime; Severity indices included measures of the most severe type of injury incurred throughout the lifetime; and Age-related indices assessed the timing of specific injury types across the lifespan. Test-retest reliabilities ranged from poor to excellent. The indices demonstrating the greatest reliability were Severity measures, with intraclass correlations for ordinal indices ranging from 0.62 to 0.78 and Cohen κ ranging from 0.50 to 0.62. One Cumulative outcome demonstrated high reliability (0.70 for number of TBIs with loss of consciousness ≥30 minutes), while the remaining Cumulative outcomes demonstrated low reliability, ranging from 0.06 to 0.21. Age-related test-retest reliabilities were fair to poor, with intraclass correlations of 0.38 to 0.49 and Cohen κ of 0.32 and 0.34. The CATI-modified Ohio State University Traumatic Brain Injury Identification Method used in this study is an effective measure for evaluating the maximum TBI severity incurred throughout the lifetime within a general population survey. The

  20. Intestinal nematodes: biology and control.

    PubMed

    Epe, Christian

    2009-11-01

    A variety of nematodes occur in dogs and cats. Several nematode species inhabit the small and large intestines. Important species that live in the small intestine are roundworms of the genus Toxocara (T canis, T cati) and Toxascaris (ie, T leonina), and hookworms of the genus Ancylostoma (A caninum, A braziliense, A tubaeforme) or Uncinaria (U stenocephala). Parasites of the large intestine are nematodes of the genus Trichuris (ie, whipworms, T vulpis). After a comprehensive description of their life cycle and biology, which are indispensable for understanding and justifying their control, current recommendations for nematode control are presented and discussed thereafter.

  1. Alconbury RAF United Kingdom Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    DTIC Science & Technology

    1984-04-01

    AD A746 q13 ALCONBURY RAF UNITED KINGDOM REVISFD UNIFORM SUMMARY OF 1/5SURFACE WEAIER 0..(t0) AIR FORCE ENVIRONMENTAL I CNICAI APPI CATI(NS CENTER...PROCESSING DIVISION USAFETAC Air Weather Service ( MAC) 0SURFACL V, LI’. ILI, I.LRVATIONS F4 ALCOjIwURY RAF UK HSIA #0362 N 52 22 W 000 13 EIEV 16OFIT EGWZ...A RAIWOKUTNMBS Air Force Environmental Technical Appi. Center Scott AFS, IL 62225 1 1 CONTROLLING OFFICE NAME AND ADDRESS OZ. REPORT DATS USAFETAC

  2. Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS).

    PubMed

    Rabinowitz, Jonathan; Schooler, Nina R; Anderson, Ariana; Ayearst, Lindsay; Daniel, David; Davidson, Michael; Khan, Anzalee; Kinon, Bruce; Menard, Francois; Opler, Lewis; Opler, Mark; Severe, Joanne B; Williamson, David; Yavorsky, Christian; Zhao, Jun

    2017-03-08

    International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.

  3. Comparing different revisions of the Childhood Health Assessment Questionnaire to reduce the ceiling effect and improve score distribution: Data from a multi-center European cohort study of children with JIA

    PubMed Central

    2010-01-01

    Background The original version of the Childhood Health Assessment Questionnaire (CHAQ30orig) suffers from a ceiling effect and hence has reduced clinical validity. The purpose of this study was to evaluate the effect of adding eight more demanding items (CHAQ38) and a new categorical response option (CATII) on discriminant validity and score distribution in a European patient sample. Methods Eighty-nine children with Juvenile Idiopathic arthritis (JIA) and 22 healthy controls, aged 7-16 years, were recruited from eight centres across Europe. Eight new CHAQ items and scoring option were translated back and forth for the countries in which they were not already present. Demographic, clinical, and CHAQ data were collected on-site. Subsequently, five different scoring methods were applied, i.e. the original method (CHAQ30orig) and four alternatives. These alternatives consisted of the mean item scores for the 30 and 38-question versions with either the original (CATI), or the new categorical response option (CATII). The five versions were tested for their ability to distinguish between patients and controls. Furthermore score distributions were evaluated and visualized by box and whisker plots. Results Two CHAQ revisions with the new response option showed poor discriminative ability, whereas one revised version (CHAQ38CATI) had comparable discriminative ability comparable to the original CHAQ. A profound ceiling effect was observed in the original scoring method of the CHAQ (27%). The addition of eight more demanding items and application of a plain mean item score reduced this significantly to 14% (χ2 = 4.21; p < 0.05). Conclusions Revising the CHAQ by adding eight more demanding items and applying a plain mean item scoring (CHAQ38CATI) maintained discriminant ability and reduced the ceiling effect in a European patient sample. The new categorical response option (CATII) seemed promising, but was less able to distinguish children with JIA from healthy controls and

  4. Mobile Phone Surveys for Collecting Population-Level Estimates in Low- and Middle-Income Countries: A Literature Review

    PubMed Central

    Pereira, Amanda; Farrenkopf, Brooke A; Labrique, Alain B; Pariyo, George W; Hyder, Adnan A

    2017-01-01

    Background National and subnational level surveys are important for monitoring disease burden, prioritizing resource allocation, and evaluating public health policies. As mobile phone access and ownership become more common globally, mobile phone surveys (MPSs) offer an opportunity to supplement traditional public health household surveys. Objective The objective of this study was to systematically review the current landscape of MPSs to collect population-level estimates in low- and middle-income countries (LMICs). Methods Primary and gray literature from 7 online databases were systematically searched for studies that deployed MPSs to collect population-level estimates. Titles and abstracts were screened on primary inclusion and exclusion criteria by two research assistants. Articles that met primary screening requirements were read in full and screened for secondary eligibility criteria. Articles included in review were grouped into the following three categories by their survey modality: (1) interactive voice response (IVR), (2) short message service (SMS), and (3) human operator or computer-assisted telephone interviews (CATI). Data were abstracted by two research assistants. The conduct and reporting of the review conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results A total of 6625 articles were identified through the literature review. Overall, 11 articles were identified that contained 19 MPS (CATI, IVR, or SMS) surveys to collect population-level estimates across a range of topics. MPSs were used in Latin America (n=8), the Middle East (n=1), South Asia (n=2), and sub-Saharan Africa (n=8). Nine articles presented results for 10 CATI surveys (10/19, 53%). Two articles discussed the findings of 6 IVR surveys (6/19, 32%). Three SMS surveys were identified from 2 articles (3/19, 16%). Approximately 63% (12/19) of MPS were delivered to mobile phone numbers collected from previously administered

  5. Enhanced luminescence properties of CaTiO(3):Pr(3+) phosphor with addition of SiO(2) by solid-state reaction.

    PubMed

    Chen, Rui; Chen, Donghua

    2014-06-05

    Red phosphors CaTiO3:Pr(3+) with addition of SiO2 were prepared by solid-state reaction technique (SS). The effect of SiO2 on the crystalline phase, surface morphology and luminescence properties of CaTiO3:Pr(3+) was studied by X-ray diffractometer, transmission electron microscope, brightness meter and photoluminescence spectrometer, respectively. The results indicated that the content of SiO2 has influence on luminescence intensity, initial brightness and persistent time of samples. The red phosphor CaTi0.5Si0.5O3:Pr(3+) exhibited the optimal luminescence properties.

  6. SEM analysis of rock varnish chemistry: A geomorphic age discriminator

    SciTech Connect

    Harrington, C.D.; Raymond, R. Jr.

    1989-07-01

    Rock varnish, a manganese- and iron-rich coating commonly found on rock surfaces in arid and semiarid regions, has long been of interest as a potential age indicator. Rock varnish has been shown to be an effective medium for dating of geomorphic surfaces over a time range of several thousand to over a million years, utilizing a ratio among minor cations ((K + Ca)/Ti) for the total volume of rock varnish. We have recently, developed a technique using the scanning electron microscope (SEM) equipped with an energy dispersive x-ray analyzer (EDAX) to analyze the chemistry of rock varnish. This technique has several advantages over the earlier cation ratio technique.

  7. New hosts and localities for helminths of carnivores in Argentina.

    PubMed

    Moleón, María Soledad; Kinsella, John Mike; Moreno, Pablo Gastón; Ferreyra, Hebe Del Valle; Pereira, Javier; Pía, Mónica; Beldomenico, Pablo Martín

    2015-12-09

    A total of 111 samples (43 faeces and 79 gastrointestinal tracts) of 14 wild carnivore species from 12 Argentine provinces were analyzed. Helminth eggs were identified in 73% of the faecal samples and adult worms were recovered from 81% of the gastrointestinal tracts. We found 19 helminth species. Among the most frequent findings were parasites of domestic carnivores, namely Toxocara canis, Toxocara cati, Toxascaris leonina, Ancylostoma caninum, Ancylostoma tubaeforme and Uncinaria stenocephala. In addition, new hosts are reported for 6 nematode species and 5 helminth species are recorded for the first time in Argentina: Aonchotheca putorii, Molineus brachiurus, Cyathospirura chevreuxi, Physaloptera praeputialis and Oncicola martini.

  8. Ocular toxocariasis in a child: a case report from Kashmir, north India.

    PubMed

    Fomda, B A; Ahmad, Z; Khan, N N; Tanveer, S; Wani, S A

    2007-10-01

    Toxocariasis is an important zoonotic disease caused by the second stage larva of Toxocara canis or Toxocara cati . The typical clinical syndromes of toxocariasis in humans are visceral and ocular toxocariasis. Ocular toxocariasis may presents as peripheral inflammatory mass, posterior pole granuloma and endophthalmitis. We report a serologically confirmed case of ocular toxocariasis in 12-year-old female. The diagnosis was confirmed by detection of anti- Toxocara antibodies in aqueous and vitreous sample by enzyme-linked immunosorbent assay. We suggest that ophthalmologist in this region should include ocular toxocariasis in differential diagnosis particularly in children and young adults.

  9. Defect chemistry and dielectric properties of Yb{sup 3+}:CaTiO{sub 3} perovskite

    SciTech Connect

    Bassoli, M.; Buscaglia, M. T.; Bottino, C.; Buscaglia, V.; Molinari, M.; Maglia, F.; Parravicini, G.; Dapiaggi, M.

    2008-01-01

    The defect chemistry of Yb{sup 3+}:CaTiO{sub 3} solid solutions has been investigated both theoretically and experimentally. Three different incorporation mechanisms with similar solution energy were predicted for Yb{sup 3+} by atomistic simulation: (i) Ca site substitution with Ca vacancy compensation; (ii) Ti site substitution with O vacancy compensation; (iii) simultaneous substitution at both Ca and Ti sites with self-compensation. X-ray diffraction and scanning electron microscopy results strongly support the possibility to realize the above defect chemistries in CaTiO{sub 3} by changing the Ca/Ti ratio to force Yb{sup 3+} on the Ca site (Ca/Ti<1), on Ti site (Ca/Ti>1), or on both sites (Ca/Ti=1) according to the calculations. The temperature dependence of the relative dielectric constant (10{sup 2}-10{sup 5} Hz) of ceramics corresponding to predominant Yb substitution either at the Ca site or the Ti site is qualitatively similar to that of undoped CaTiO{sub 3}. The Curie-Weiss temperature is shifted to more negative values in comparison to CaTiO{sub 3}, suggesting that the compositions Ca{sub 1-3/2x}Yb{sub x}TiO{sub 3} and CaYb{sub x}Ti{sub 1-x}O{sub 3} are further driven away from the ferroelectric instability. In contrast, the dielectric properties (10{sup 2}-10{sup 5} Hz) of ceramics corresponding to Ca{sub 1-x/2}Yb{sub x}Ti{sub 1-x/2}O{sub 3} are radically different. The relative dielectric constant is increased of about one order of magnitude (2200 at 30 K), is almost independent of temperature, with a maximum variation of 20% in range of 20-300 K, and shows frequency dispersion above 150 K. The loss tangent at 20-300 K is <5% for frequencies {>=}1 kHz. The possible mechanism for the observed dielectric behavior is discussed.

  10. The clinical and demographic features of dizziness related to general health among the Saudi population

    PubMed Central

    Al Saif, Amer; Al Senany, Samira

    2015-01-01

    [Purpose] The purpose of this study was to determine the validity, demographic features of the newly developed Amer Dizziness Diagnostic Scale (ADDS), provide differential diagnosis of the vestibular disorders, assist in the clinical research and practice activities of health workers as well as to understand the probability of the utilization of the ADDS as a first-line evaluation tool in general clinical practice. [Subjects and Methods] Two hundred subjects of various ages including both male and female patients with a history of vertigo and/or dizziness were included in the study and evaluated once using the ADDS. [Results] There were more female (59.5%) than male (49.5) patients in this study. Additionally, we found that most patients (64.4%) had a central mediated problem. In addition, the Amer Dizziness Diagnostic Scale has been found to have both a sensitivity and specificity of 96% that can adequately determine the possible diagnosis of vestibular disorders. [Conclusion] This study has demonstrated the validity of the ADDS scale, the predominance of female involvement related to supplementary medication, vitamin D deficiency, general lifestyle factors, and fluid retention, high sensitivity and specificity, provide differential diagnosis of vestibular disorders that could be used as a first-line evaluation tool in general clinics. PMID:26644673

  11. Real Paley-Wiener theorems for the Koornwinder-Swarttouw q-Hankel transform

    NASA Astrophysics Data System (ADS)

    Abreu, Luís Daniel

    2007-10-01

    We derive two real Paley-Wiener theorems in the setting of quantum calculus. The first uses techniques due to Tuan and Zayed [V.K. Tuan, A.I. Zayed, Paley-Wiener-type theorems for a class of integral transforms, J. Math. Anal. Appl. 266 (1) (2002) 200-226] in order to describe the image of the space under Koornwinder and Swarttouw q-Hankel transform [T.H. Koornwinder, REF. Swarttouw, On q-analogues of the Fourier and Hankel transforms, TransE Amer. Math. Soc. 333 (1) (1992) 445-461] and contains as a special case a description of the domain of the q-sampling theorem associated with the q-Hankel transform [L.D. Abreu, A q-sampling theorem related to the q-Hankel transform, Proc. Amer. Math. Soc. 133 (4) (2005) 1197-1203]. The second characterizes the image of compactly supported q-smooth functions under a rescaled version of the q-Hankel transform and is a q-analogue of a recent result due to Andersen [N.B. Andersen, Real Paley-Wiener theorems for the Hankel transform, J. Fourier Anal. Appl. 12 (1) (2006) 17-25].

  12. Gesture recognition in patients with aphasia.

    PubMed

    Daniloff, J K; Noll, J D; Fristoe, M; Lloyd, L L

    1982-02-01

    This study focuses on the controversial issue of the integrity of gestural communication abilities in subjects with aphasia. To define the ability of subjects to interpret symbolic gestures, an Amer-Ind Recognition Test (ART) was developed which required no verbal response from the examiner or the subject. The relationships between impairment of Amer-Ind signal recognition and (a) severity of aphasia, (b) listening and talking abilities and (c) the type of response picture used were investigated. Whether subjects more often chose related foils than unrelated foils in a forced-choice format was also examined. Two training tests and the ART are described. Results from administration to 15 aphasic subjects indicated that: (a) all subjects performed equally well, regardless of their aphasia severity classification; (b) action picture recognition was related to listening ability; (c) action pictures were easier to identify than object pictures; and (d) on error responses, subjects overwhelmingly chose related over unrelated foils. The possibility that gestural abilities were relatively well preserved among the subjects tested, in the presence of a wide range of listening and talking deficits, is also discussed.

  13. Loewner Theory in annulus II: Loewner chains

    NASA Astrophysics Data System (ADS)

    Contreras, Manuel D.; Díaz-Madrigal, Santiago; Gumenyuk, Pavel

    2011-12-01

    Loewner Theory, based on dynamical viewpoint, proved itself to be a powerful tool in Complex Analysis and its applications. Recently Bracci et al. (J Reine Angew Math to appear, arXiv:0807.1594; Math Ann 344:947-962, 2009) and Contreras et al. (Revista Matemática Iberoamericana 26:975-1012, 2010) have proposed a new approach bringing together all the variants of the (deterministic) Loewner Evolution in a simply connected reference domain. This paper is devoted to the construction of a general version of Loewner Theory for the annulus launched in Contreras et al. (Trans Amer Math Soc to appear, arXiv:1011.4253). We introduce the general notion of a Loewner chain over a system of annuli and obtain a 1-to-1 correspondence between Loewner chains and evolution families in the doubly connected setting similar to that in the Loewner Theory for the unit disk. Furthermore, we establish a conformal classification of Loewner chains via the corresponding evolution families and via semicomplete weak holomorphic vector fields. Finally, we extend the explicit characterization of the semicomplete weak holomorphic vector fields obtained in Contreras et al. (Trans Amer Math Soc to appear, arXiv:1011.4253) to the general case.

  14. Comparative effectiveness of atypical antipsychotics in schizophrenia: what have real-world trials taught us?

    PubMed

    Attard, Azizah; Taylor, David M

    2012-06-01

    Real-world, effectiveness studies add an important new dimension to the evaluation of the benefits of individual antipsychotics. Efficacy studies have already shown the unique effectiveness of clozapine, and suggested improved outcomes for olanzapine compared with some atypical antipsychotics and a reduced tendency to produce acute and chronic movement disorders for atypical compared with typical drugs. Recent effectiveness studies largely confirm these prior observations. The CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness), CUtLASS (Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study) and SOHO (Schizophrenia Outpatient Health Outcomes) programmes confirmed the superiority of clozapine over other antipsychotics; CATIE and SOHO also confirmed olanzapine as probably the second most effective antipsychotic. Effectiveness studies have confirmed the high incidence of adverse metabolic effects with clozapine, olanzapine and (with less certainty) quetiapine but the ZODIAC (Ziprasidone Observational Study of Cardiac Outcomes) study found no excess cardiovascular events or deaths for olanzapine compared with ziprasidone. Prior observations on reduced frequency of movement disorders for second-generation versus first-generation antipsychotics were also largely (but not uniformly) supported. Overall, recent real-world studies have done much to confirm prior observations from efficacy-based randomized, controlled trials.

  15. Prevalence of enteric zoonotic agents in cats less than 1 year old in central New York State.

    PubMed

    Spain, C V; Scarlett, J M; Wade, S E; McDonough, P

    2001-01-01

    A prevalence study of several enteric zoonotic bacterial and parasitic infections was conducted in 263 fecal samples from cats that were between 1 and 12 months old, and that were in humane shelters (n = 149) or were presented to primary-care veterinarians (n = 114). Of these samples, 2 (0.8%) were positive for Campylobacter, 2 (0.8%) were positive for Salmonella, and 10 (3.8%) were positive for Cryptosporidium, confirming that these zoonotic agents are relatively rare in cats. Toxocara cati (33.0%) and Giardia (7.3%) were found more commonly. At least 1 zoonotic agent was detected in 105 samples (40.7%). Our results suggest that clinical signs such as diarrhea are not reliable predictors of whether a cat is actively shedding enteric organisms. Therefore, the decision to test a newly adopted cat should be based on the potential risks to the client rather than on the cat's clinical presentation. The high prevalence of T. cati confirms that comprehensive testing or treatment for ascarids is warranted in newly adopted kittens.

  16. Epizootic and zoonotic helminths of the bobcat (Lynx rufus) in Illinois and a comparison of its helminth component communities across the American Midwest

    PubMed Central

    Hiestand, Shelby J.; Nielsen, Clayton K.; Jiménez, F. Agustín

    2014-01-01

    A total of 6257 helminths of 19 taxa were recovered from the digestive tract and lungs of 67 bobcats in Illinois. Infections caused by Alaria mustelae, Diphyllobothrium latum, and Macracanthorhynchus ingens are reported for the first time in bobcats. From all the taxa recovered, only three species occurred in high prevalence and caused intense infections: Taenia rileyi, Alaria marcianae, and Toxocara cati, with prevalence and mean intensity of 70% and 6; 42% and 193, and 25% and 14 individuals, respectively. Prevalence lower than 15% of 14 helminth species suggests bobcats are not continuously exposed to infective stages of a single parasite, and may be exposed to a large variety of generalists during their lifespan. No significant difference in parasite species according to host sex or age was detected, except for Diphyllobothrium spp., which were found more frequently in females and in trapped bobcats, and the hookworm, Ancylostoma caninum, which infected juveniles more frequently. Average species richness per infracommunity was 2.4 (±1.2), and the parasite component community showed low qualitative similarity with neighbor communities. The taxa A. caninum, Alaria spp., Diphyllobothrium spp., Paragonimus kellicotti, and T. cati are etiological agents of epizootic and zoonotic diseases. PMID:24521984

  17. The prevalence of intestinal nematodes in cats and dogs from Lancashire, north-west England.

    PubMed

    Wright, I; Stafford, K; Coles, G

    2016-08-01

    To estimate prevalence of clinically-relevant intestinal nematodes in UK cats and dogs using the sensitive faecal analysis technique FLOTAC. Faecal samples were collected from 171 domestic dogs and 131 domestic cats living in urban areas of Lancashire and examined for the ova of intestinal parasites using the FLOTAC technique. All tested individuals were at least 6 months old, had not been treated with anthelmintics since 6 months of age nor in the 3 weeks prior to testing. In total, 5·3% of dogs (9/171) were positive for Toxocara canis; of these, 5/9 had <100 T. canis epg. Two dogs were positive for Uncinaria stenocephala, and 3 were positive for Strongyloides species. Single animals had Ancylostoma species and Spirocerca lupi infection. All egg counts were <100 epg. 26% of cats (34/131) were infected with Toxocara cati; of these, 6/34 had <100 T. cati epg. Two cats were positive for Strongyloides species, four for Ancylostoma species and single case for U. stenocephala, Toxascaris leonina and S. lupi. The high prevalence and zoonotic potential of Toxocara species in cats and dogs suggests the need for greater awareness of the need for repeated treatment. The discovery of S. lupi warrants further investigation and awareness of the clinical signs that this parasite may cause in cats and dogs. © 2016 British Small Animal Veterinary Association.

  18. Imidacloprid/moxidectin topical solution for the prevention of heartworm disease and the treatment and control of flea and intestinal nematodes of cats.

    PubMed

    Arther, R G; Charles, S; Ciszewski, D K; Davis, W L; Settje, T S

    2005-10-24

    Sixteen controlled laboratory studies, involving 420 kittens and cats, were conducted to evaluate the efficacy and safety of topically applied formulations of imidacloprid and moxidectin for the prevention of feline heartworm disease, treatment of flea infestations and treatment and control of intestinal nematodes. Unit-dose applicators and the dosing schedule used in these studies were designed to provide a minimum of 10mg imidacloprid and 1mg moxidectin/kg. Treatments were applied topically by parting the hair at the base of the skull and applying the solution on the skin. Imidacloprid treatment alone did not display activity against Dirofilaria immitis or intestinal nematodes and moxidectin treatment alone provided little or no activity against adult Ctenocephalides felis infestations. The formulation containing 10% imidacloprid and 1% moxidectin was 100% efficacious against the development of adult D. immitis infections when cats were treated 30 days after inoculation with third-stage larvae. A single treatment with this formulation also provided 88.4-100% control of adult C. felis for 35 days. Imidacloprid/moxidectin was 100% efficacious against adult Toxocara cati and 91.0-98.3% efficacious against immature adults and fourth-stage T. cati larvae. The formulation provided 98.8-100% efficacy against adult Ancylostoma and immature adults and third-stage A. tubaeforme larvae. Monthly topical application with 10% imidacloprid/1% moxidectin is convenient, efficacious and safe for the prevention of feline heartworm disease, treatment of flea infestation and for the treatment and control of intestinal nematode infections of cats.

  19. Effects of Toxocara larvae on brain cell survival by in vitro model assessment.

    PubMed

    Heuer, Lea; Haendel, Sabine; Beineke, Andreas; Strube, Christina

    2015-09-01

    Neuroinvasive larvae of the common dog and cat roundworms, Toxocara canis and Toxocara cati, may cause severe neurological and neuropsychological disturbances in humans. Despite their pathogenic potential and high prevalence worldwide, little is known about their cell-specific influences and cerebral host-pathogen interactions in neurotoxocarosis. To address this discrepancy, a co-culture system of viable larvae with murine neuronal (CAD), oligodendrocytal (BO-1) and microglial (BV-2) cell lines has been established. Additionally, murine adult brain slices have been co-cultured with Toxocara larvae to consider complex organotypic cell-cell interplay. Cytotoxicity of larval presence was measured enzymatically and microscopically. Microscopic evaluation using trypan blue exclusion assay revealed to be less reliable and sensitive than the lactate dehydrogenase activity assay. Ultimately, even low numbers of both T. canis and T. cati larvae have impaired survival of differentiated CAD cells, which morphologically resemble primary neurons. In contrast, viability of oligodendrocytal and microglial cells as well as brain slices was not impaired by larval presence. Therefore, immune-mediated mechanisms or trauma by migrating larvae presumably induce the in vivo pathology rather than acute cytotoxic effects. Conclusively, the helminthic larvae co-culture system presented here is a valuable in vitro tool to study cell-specific effects of parasitic larvae and their products.

  20. Validation of an abbreviated quality of life scale for schizophrenia.

    PubMed

    Fervaha, Gagan; Remington, Gary

    2013-09-01

    The field of therapeutics in schizophrenia is redefining optimal outcome, moving beyond clinical remission to a more comprehensive model that also includes functional recovery. The Quality of Life Scale (QLS) has been adopted by many large clinical trials, including CATIE and CUtLASS, as a measure of functioning. The QLS is a 21-item semi-structured interview that takes approximately 45min to administer. Although the QLS is considered comprehensive, its length limits its applicability across studies. To circumvent this issue, short scales of the QLS have been created that estimate total scores with high accuracy. However, these abbreviated measures have not been adequately cross-validated in a large enough sample to allow for subsample estimations nor has its predictive ability been compared to the full scale. Here, we used data from the CATIE trial (n=1460) to demonstrate the validity and utility of an abbreviated 7-item QLS. The shortened QLS was robust in estimating total scores (r=0.953, p<0.001) across subsamples and demonstrated predictive ability similar to the full QLS in multiple regression models. The abridged QLS is recommended as a surrogate measure of psychosocial functioning, especially in cases where functioning is not the primary outcome. Copyright © 2012 Elsevier B.V. and ECNP. All rights reserved.

  1. Inter-method reliability of paper surveys and computer assisted telephone interviews in a randomized controlled trial of yoga for low back pain.

    PubMed

    Cerrada, Christian J; Weinberg, Janice; Sherman, Karen J; Saper, Robert B

    2014-04-09

    Little is known about the reliability of different methods of survey administration in low back pain trials. This analysis was designed to determine the reliability of responses to self-administered paper surveys compared to computer assisted telephone interviews (CATI) for the primary outcomes of pain intensity and back-related function, and secondary outcomes of patient satisfaction, SF-36, and global improvement among participants enrolled in a study of yoga for chronic low back pain. Pain intensity, back-related function, and both physical and mental health components of the SF-36 showed excellent reliability at all three time points; ICC scores ranged from 0.82 to 0.98. Pain medication use showed good reliability; kappa statistics ranged from 0.68 to 0.78. Patient satisfaction had moderate to excellent reliability; ICC scores ranged from 0.40 to 0.86. Global improvement showed poor reliability at 6 weeks (ICC = 0.24) and 12 weeks (ICC = 0.10). CATI shows excellent reliability for primary outcomes and at least some secondary outcomes when compared to self-administered paper surveys in a low back pain yoga trial. Having two reliable options for data collection may be helpful to increase response rates for core outcomes in back pain trials. ClinicalTrials.gov: NCT01761617. Date of trial registration: December 4, 2012.

  2. Frequency of gastrointestinal parasites in cats seen at the University of São Paulo Veterinary Hospital, Brazil.

    PubMed

    Gennari, Solange Maria; Ferreira, Juliana Isabel Giuli da Silva; Pena, Hilda Fátima de Jesus; Labruna, Marcelo Bahia; Azevedo, Sérgio Dos Santos

    2016-01-01

    The frequency of gastrointestinal infections in 502 cats seen at the Veterinary Hospital of the University of São Paulo, SP, Brazil, between 2005 and 2014, was measured. The samples were analyzed using methods of flotation and sedimentation. The results were compared with those from studies published previously using fecal samples from the same hospital at different times. Associations between the frequency of positivity for each parasite and age, breed, sex, diarrhea and use of anthelmintic were investigated (chi-square or Fisher's exact tests). A partitioned chi-square test was used to compare different periods. Cryptosporidium spp., Giardia spp., Cystoisospora spp. and Sarcocystis spp. were the most common parasites, followed by Toxocara cati and Ancylostoma spp. Cryptosporidium spp. presented higher frequency in young cats and Sarcocystis spp. with the presence of diarrhea (p < 0.05). Results from this study with previous periods showed that the frequencies of Cryptosporidium spp., Cystoisospora spp. and T. cati were lower (p < 0.05) than those observed in previous periods. The frequencies of Giardia spp. and Ancylostoma spp. were similar to the results found in the preceding period and lower than the values found for the other periods (p < 0.05). The reasons for these changes should be investigated.

  3. Is alcohol and community sport a good mix? Alcohol management, consumption and social capital in community sports clubs.

    PubMed

    Rowland, Bosco C; Wolfenden, Luke; Gillham, Karen; Kingsland, Melanie; Richardson, Ben; Wiggers, John

    2015-06-01

    Community sports clubs provide an important contribution to the health and wellbeing of individuals and the community; however, they have also been associated with risky alcohol consumption. This study assessed whether a club's alcohol management strategies were related to risky alcohol consumption by members and levels of social capital, as measured in terms of participation in and perceived safety of the club. A total of 723 sports club members from 33 community football clubs in New South Wales, Australia, completed a computer assisted telephone interview (CATI) and a management representative from each club also completed a CATI. The club representative reported on the club's implementation of 11 alcohol management practices, while club members reported their alcohol consumption and perceived levels of safety at the club and participation in the club. A structural equation model identified having the bar open for more than four hours; having alcohol promotions; and serving intoxicated patrons were associated with increased risky alcohol consumption while at the club; which in turn was associated with lower levels of perceived club safety and member participation. The positive contribution of community sports clubs to the community may be diminished by specific inadequate alcohol management practices. Changing alcohol management practices can reduce alcohol consumption, and possibly increase perceived aspects of social capital, such as safety and participation. © 2014 Public Health Association of Australia.

  4. Survey of infectious and parasitic diseases in stray cats at the Lisbon Metropolitan Area, Portugal.

    PubMed

    Duarte, Ana; Castro, Isabel; Pereira da Fonseca, Isabel M; Almeida, Virgilio; Madeira de Carvalho, Luis M; Meireles, José; Fazendeiro, Maria I; Tavares, Luis; Vaz, Yolanda

    2010-06-01

    A survey of infectious and parasitic diseases of stray cats was carried out using biological samples collected from animals captured during a catch-neuter-release programme in four counties of the Lisbon Metropolitan Area. The main objective was to investigate the potential threat of stray cats for animal and public health. Samples of blood, stool, hair and auricular swabs were collected from 231 cats in 27 colonies. Anti-Toxoplasma gondii antibodies were detected in 47/194 samples (24.2%); anti-Leishmania infantum antibodies in 1/180 cats (0.6%); intestinal parasites in 23/74 samples (Toxocara cati, Isospora felis, Ancylostoma tubaeforme, Dipylidium caninum, Uncinaria stenocephala, Toxascaris leonina) and Otodectes cynotis in 4/182 cats (2.2%); dermatophyte fungi were isolated in 40/136 samples (29.4%); feline immunodeficiency virus antibodies were detected in 23/226 samples (10.2%); feline leukaemia virus antigen in 14/198 samples (7.1%); and feline coronavirus RNA in 9/127 samples (7.1%). Our results revealed that zoonotic agents, namely dermatophyte fungi and Toxocara cati were present in stray cat colonies in the investigated counties. Overall the low frequency of major pathogens suggests a balanced relationship between host and agents.

  5. Endoparasites of the Eurasian lynx (Lynx lynx) in Finland.

    PubMed

    Deksne, Gunita; Laakkonen, Juha; Näreaho, Anu; Jokelainen, Pikka; Holmala, Katja; Kojola, Ilpo; Sukura, Antti

    2013-04-01

    We sampled 339 fecal samples, 296 intestines, and 82 lungs from 371 lynx hunted during the 2010-2011 season in Finland. The fecal samples were analyzed for endoparasites by a quantitative flotation method, and helminths from intestines were studied morphologically, while lungs were investigated for pulmonary parasites. From fecal samples, eggs and oocysts of at least 6 different endoparasite species were identified, with a mean of 1.5 (range 0-4) parasite species per host. In the intestines, at least 4 different helminth species were found, with the mean of 2.0 (range 1-4) species per infected host. The prevalence of eggs in feces and the prevalence of worms in intestines were 71% and 93% for Toxocara cati , 29% and 68% for Taenia spp., and 5% and 2% for Diphyllobothrium sp., respectively. Only eggs were detected for Capillaria sp. (46%) and Uncinaria sp. (0.6%) nematodes, and only adults were detected for Mesocestoides sp. cestodes (0.3%). Significant positive correlations were evident between the number of T. cati (r = 0.664; P = 0.01) and Diphyllobothrium sp. (r = 0.645; P = 0.01) eggs per gram of feces and adult worms detected in intestine. In addition to the metazoan parasites, protozoan Isospora sp. oocysts were also found (0.6%). Pulmonary samples were all negative for parasites. These data demonstrate that lynx commonly harbor various endoparasites, some of which are zoonotic.

  6. Maximising response rates in household telephone surveys

    PubMed Central

    O'Toole, Joanne; Sinclair, Martha; Leder, Karin

    2008-01-01

    Background Epidemiological and other studies that require participants to respond by completing a questionnaire face the growing threat of non-response. Response rates to household telephone surveys are diminishing because of changes in telecommunications, marketing and culture. Accordingly, updated information is required about the rate of telephone listing in directories and optimal strategies to maximise survey participation. Methods A total of 3426 households in Sydney, Australia were approached to participate in a computer assisted telephone interview (CATI) regarding their domestic (recycled and/or drinking) water usage. Only randomly selected households in the suburb and postcode of interest with a telephone number listed in the Electronic White Pages (EWP) that matched Australian electoral records were approached. Results The CATI response rate for eligible households contacted by telephone was 39%. The rate of matching of electoral and EWP records, a measure of telephone directory coverage, was 55%. Conclusion The use of a combination of approaches, such as an advance letter, interviewer training, establishment of researcher credentials, increasing call attempts and targeted call times, remains a good strategy to maximise telephone response rates. However, by way of preparation for future technological changes, reduced telephone number listings and people's increasing resistance to unwanted phone calls, alternatives to telephone surveys, such as internet-based approaches, should be investigated. PMID:18980694

  7. Road Killed Carnivores Illustrate the Status of Zoonotic Helminthes in Caspian Sea Littoral of Iran.

    PubMed

    Vafae Eslahi, Aida; Kia, Eshrat Beigom; Mobedi, Iraj; Sharifdini, Meysam; Badri, Milad; Mowlavi, Gholamreza

    2017-01-01

    Carnivore carcasses on the roads can be regarded as study materials in parasitology and eco-epidemiology. Stray carnivores such as dogs and cats are known to harbor so many different pathogens like zoonotic helminthes. The current investigation, apparent the status of the helminthic parasites found in road killed carnivores from different parts of Guilan Province north of Iran. Fifty road killed carnivores including 27 stray dogs (Canis familiaris), 11 golden jackals (Canis aureus) and 12 stray cats (Felis catus) were collected from 21 locations of Guilan Province, during Apr to Nov 2015. Internal organs of the carcasses, including digestive tract, heart, kidneys, lungs, liver, skin, eyes as well as muscles were carefully inspected and sampled for helminthological investigation. About 80% of the 50 carnivores, (stray dogs 77.77%, golden jackals 81.81%, and stray cats 91.66%) were found naturally infected with helminthic parasites. Dipylidum caninum, Toxocara cati, Toxocara canis, Toxascaris leonine, Ancylostoma caninum, Ancylostoma tubaeforme, Dirofilaria immitis, Dioctophyma renale, Dipylidum caninum, Echinococcus granulosus, Mesocestoides spp., Taenia hydatigena, Taenia hydatigera, Joyuxiella spp., Spirometra spp. are reported herein. The prevalent occurrence of zoonotic helminthes such as T. canis, T. cati, T. leonina, E. granulosus, D. immitis and D. renale in stray carnivores should be considered as a public health hazard, specifically within a vast tourism area like Guilan Province.

  8. High prevalence of helminth parasites in feral cats in Majorca Island (Spain).

    PubMed

    Millán, Javier; Casanova, Joan Carles

    2009-12-01

    Feral cats are widespread in the countryside of Majorca (Balearic Islands, Spain). Since they are not subject of sanitary control, they can act as reservoir of parasites of veterinary and zoonotic interest. The main organs of 58 wild-trapped cats in 16 different areas from Majorca were analyzed by helminths. All the cats were parasitized, and eight species of helminths were retrieved (mean = 3.4 species per cat, with 74% of the cats harboring three or more species). Seven of them presented a prevalence >20%: Joyeuxiella pasqualei (76%), Diplopylidium acanthotetra (60%), Dipylidium carracidoi (33%), Taenia taeniaeformis (22%), Ancylostoma tubaeforme (91%), and Toxocara cati (35%) in the gastrointestinal tract, and Oslerus rostratus (24%) in lungs. The A. tubaeforme prevalence and intensity (mean = 30, up to 396) is the highest recorded for a population of cats. Prevalence and abundance of J. pasqualei and D. acanthotetra were strongly associated, secondary to the use of the same intermediary host (geckos). Other positive associations found are probably related to host susceptibility. Abundance of D. acanthotetra, T. cati, and A. tubaeforme and the number of species per host were negatively correlated with cat body condition (assessed by the kidney fat index). Females were more frequently parasitized by A. tubaeforme than males, and adult females were more heavily infested by J. pasqualei and D. acanthotetra than cats from other groups. These and other findings are discussed in relation with host ecology. Feral cats serve as reservoirs of helminths in the countryside of Majorca and their populations should be controlled.

  9. Road Killed Carnivores Illustrate the Status of Zoonotic Helminthes in Caspian Sea Littoral of Iran

    PubMed Central

    VAFAE ESLAHI, Aida; KIA, Eshrat Beigom; MOBEDI, Iraj; SHARIFDINI, Meysam; BADRI, Milad; MOWLAVI, Gholamreza

    2017-01-01

    Background: Carnivore carcasses on the roads can be regarded as study materials in parasitology and eco-epidemiology. Stray carnivores such as dogs and cats are known to harbor so many different pathogens like zoonotic helminthes. The current investigation, apparent the status of the helminthic parasites found in road killed carnivores from different parts of Guilan Province north of Iran. Methods: Fifty road killed carnivores including 27 stray dogs (Canis familiaris), 11 golden jackals (Canis aureus) and 12 stray cats (Felis catus) were collected from 21 locations of Guilan Province, during Apr to Nov 2015. Internal organs of the carcasses, including digestive tract, heart, kidneys, lungs, liver, skin, eyes as well as muscles were carefully inspected and sampled for helminthological investigation. Results: About 80% of the 50 carnivores, (stray dogs 77.77%, golden jackals 81.81%, and stray cats 91.66%) were found naturally infected with helminthic parasites. Dipylidum caninum, Toxocara cati, Toxocara canis, Toxascaris leonine, Ancylostoma caninum, Ancylostoma tubaeforme, Dirofilaria immitis, Dioctophyma renale, Dipylidum caninum, Echinococcus granulosus, Mesocestoides spp., Taenia hydatigena, Taenia hydatigera, Joyuxiella spp., Spirometra spp. are reported herein. Conclusion: The prevalent occurrence of zoonotic helminthes such as T. canis, T. cati, T. leonina, E. granulosus, D. immitis and D. renale in stray carnivores should be considered as a public health hazard, specifically within a vast tourism area like Guilan Province. PMID:28761483

  10. Epizootic and zoonotic helminths of the bobcat (Lynx rufus) in Illinois and a comparison of its helminth component communities across the American Midwest.

    PubMed

    Hiestand, Shelby J; Nielsen, Clayton K; Jiménez, F Agustín

    2014-01-01

    A total of 6257 helminths of 19 taxa were recovered from the digestive tract and lungs of 67 bobcats in Illinois. Infections caused by Alaria mustelae, Diphyllobothrium latum, and Macracanthorhynchus ingens are reported for the first time in bobcats. From all the taxa recovered, only three species occurred in high prevalence and caused intense infections: Taenia rileyi, Alaria marcianae, and Toxocara cati, with prevalence and mean intensity of 70% and 6; 42% and 193, and 25% and 14 individuals, respectively. Prevalence lower than 15% of 14 helminth species suggests bobcats are not continuously exposed to infective stages of a single parasite, and may be exposed to a large variety of generalists during their lifespan. No significant difference in parasite species according to host sex or age was detected, except for Diphyllobothrium spp., which were found more frequently in females and in trapped bobcats, and the hookworm, Ancylostoma caninum, which infected juveniles more frequently. Average species richness per infracommunity was 2.4 (±1.2), and the parasite component community showed low qualitative similarity with neighbor communities. The taxa A. caninum, Alaria spp., Diphyllobothrium spp., Paragonimus kellicotti, and T. cati are etiological agents of epizootic and zoonotic diseases.

  11. Prevalence of chlamydia, toxoplasma, toxocara and ringworm in farm cats in south-west England.

    PubMed

    Gethings, P M; Stephens, G L; Wills, J M; Howard, P; Balfour, A H; Wright, A I; Morgan, K L

    1987-09-05

    The prevalence of infection with Chlamydia psittaci, Toxoplasma gondii, Toxocara cati and Microsporum canis was examined in 51 cats on 22 sheep farms in the Bristol area. Serum antibody to C psittaci and T gondii was present in 45 per cent and 47 per cent of cats, respectively. At the time of sampling C psittaci was isolated from 6 per cent of the cats, T cati was identified in 63 per cent of faecal samples but neither T gondii nor M canis was isolated. When examined according to the farm of origin, 22.7 per cent of farms had cat populations with no evidence of infection with C psittaci or T gondii. Of the remainder, 45.5 per cent supported cat populations with evidence of both infections and 31.8 per cent had evidence of T gondii infection alone. None of the farms had cat populations with evidence of C psittaci infection alone. Two of the cats infected with C psittaci were excreting viable organisms in the faeces. The possible significance of this to the epidemiology of ovine enzootic abortion is discussed.

  12. Inter-method reliability of paper surveys and computer assisted telephone interviews in a randomized controlled trial of yoga for low back pain

    PubMed Central

    2014-01-01

    Background Little is known about the reliability of different methods of survey administration in low back pain trials. This analysis was designed to determine the reliability of responses to self-administered paper surveys compared to computer assisted telephone interviews (CATI) for the primary outcomes of pain intensity and back-related function, and secondary outcomes of patient satisfaction, SF-36, and global improvement among participants enrolled in a study of yoga for chronic low back pain. Results Pain intensity, back-related function, and both physical and mental health components of the SF-36 showed excellent reliability at all three time points; ICC scores ranged from 0.82 to 0.98. Pain medication use showed good reliability; kappa statistics ranged from 0.68 to 0.78. Patient satisfaction had moderate to excellent reliability; ICC scores ranged from 0.40 to 0.86. Global improvement showed poor reliability at 6 weeks (ICC = 0.24) and 12 weeks (ICC = 0.10). Conclusion CATI shows excellent reliability for primary outcomes and at least some secondary outcomes when compared to self-administered paper surveys in a low back pain yoga trial. Having two reliable options for data collection may be helpful to increase response rates for core outcomes in back pain trials. Trial registration ClinicalTrials.gov: NCT01761617. Date of trial registration: December 4, 2012. PMID:24716775

  13. Visceral larva migrans syndrome: analysis of serum cytokine levels in children with hepatic lesions confirmed in radiological findings.

    PubMed

    Mazur-Melewska, K; Jończyk, K; Modlińska-Cwalińska, A; Figlerowicz, M; Służewski, W

    2014-12-01

    Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms Toxocara canis (T. canis) and cati (T. cati). The infection occurs in five forms: systemic (VLM), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immunological findings in hepatic inflammation during the course of systemic infection by Toxocara sp. in children. Fifteen children, 2 to 17 years of age, with serological diagnosis of T. canis infection underwent abdominal ultrasonography and computer tomography (CT). Eosinophil counts, immunoglobulin E titres, interleukins IL-1α, IL-4, Il-6, IL-10 and interferon gamma were measured for all patients. Abdominal ultrasound revealed multiple hypoechoic areas in the livers of all patients. On the CT images, the hepatic lesions were seen as multiple, ill-defined, oval low-attenuating nodules that measured 6 to 9 millimetres in diameter. The nodules were usually best seen in the portal venous phase and were not seen on arterial-phase images. Significant intergroup differences were observed in the concentrations of IL-1α, IL-4, IL-6 and IL-10. The level of IFN-γ was not significantly elevated in patient sera relative to controls. The analysis shows that the production of anti-inflammatory cytokines is insufficient for granuloma formation in children presenting liver lesions in the course of VLM.

  14. Maximising response rates in household telephone surveys.

    PubMed

    O'Toole, Joanne; Sinclair, Martha; Leder, Karin

    2008-11-03

    Epidemiological and other studies that require participants to respond by completing a questionnaire face the growing threat of non-response. Response rates to household telephone surveys are diminishing because of changes in telecommunications, marketing and culture. Accordingly, updated information is required about the rate of telephone listing in directories and optimal strategies to maximise survey participation. A total of 3426 households in Sydney, Australia were approached to participate in a computer assisted telephone interview (CATI) regarding their domestic (recycled and/or drinking) water usage. Only randomly selected households in the suburb and postcode of interest with a telephone number listed in the Electronic White Pages (EWP) that matched Australian electoral records were approached. The CATI response rate for eligible households contacted by telephone was 39%. The rate of matching of electoral and EWP records, a measure of telephone directory coverage, was 55%. The use of a combination of approaches, such as an advance letter, interviewer training, establishment of researcher credentials, increasing call attempts and targeted call times, remains a good strategy to maximise telephone response rates. However, by way of preparation for future technological changes, reduced telephone number listings and people's increasing resistance to unwanted phone calls, alternatives to telephone surveys, such as internet-based approaches, should be investigated.

  15. Comparison of six simple methods for extracting ribosomal and mitochondrial DNA from Toxocara and Toxascaris nematodes.

    PubMed

    Mikaeili, F; Kia, E B; Sharbatkhori, M; Sharifdini, M; Jalalizand, N; Heidari, Z; Zarei, Z; Stensvold, C R; Mirhendi, H

    2013-06-01

    Six simple methods for extraction of ribosomal and mitochondrial DNA from Toxocara canis, Toxocara cati and Toxascaris leonina were compared by evaluating the presence, appearance and intensity of PCR products visualized on agarose gels and amplified from DNA extracted by each of the methods. For each species, two isolates were obtained from the intestines of their respective hosts: T. canis and T. leonina from dogs, and T. cati from cats. For all isolates, total DNA was extracted using six different methods, including grinding, boiling, crushing, beating, freeze-thawing and the use of a commercial kit. To evaluate the efficacy of each method, the internal transcribed spacer (ITS) region and the cytochrome c oxidase subunit 1 (cox1) gene were chosen as representative markers for ribosomal and mitochondrial DNA, respectively. Among the six DNA extraction methods, the beating method was the most cost effective for all three species, followed by the commercial kit. Both methods produced high intensity bands on agarose gels and were characterized by no or minimal smear formation, depending on gene target; however, beating was less expensive. We therefore recommend the beating method for studies where costs need to be kept at low levels.

  16. Helminth and protozoan parasites in dogs and cats in Belgium.

    PubMed

    Vanparijs, O; Hermans, L; van der Flaes, L

    1991-01-01

    This study investigates the level of helminthic and protozoal infestation over the last 10 years in strays, well-cared-for dogs and cats. Determination of the prevalence of infections was based either on faecal examination or on worm counts at necropsy. Of 2324 faecal flotations (NaCl sp.gr. 1.20) of stray dogs, 34.2% had eggs or proglottids of one or more worm species consisting of Toxocara canis (17.4%), Toxascaris leonina (10.1%), Uncinaria stenocephala (11.4%), Trichuris vulpis (7.0%) and cestodes (2.1%). Isospora oocysts were observed in 5.2% of the dogs. The data on the distribution of the various worm species in the positive dogs indicate that T. canis eggs were by far the most common (50.9%). Necropsy data from 212 infected dogs indicate that 38.9% were infected with T. canis and 33.7% with T. leonina. The overall prevalence of worm infestation of 246 well-cared-for kennel dogs, based on worm egg counts by the McMaster technique, was 36.1%. Of 30 feline faecal samples examined by flotation, 83.3% were positive for parasites, including Toxocara cati (60%), Ancylostoma tubaeformae (36.6%), Taenia (Hydatigera) taeniaeformis (20%) and coccidia (30%). Toxocara cati was the most frequently found worm species at the necropsy of 25 cats (52%). Toxoplasma was not observed.

  17. A Hydroalcoholic Extract from Paullinia pinnata L. Roots Exerts Anthelmintic Activity against Free-Living and Parasitic Nematodes.

    PubMed

    Spiegler, Verena; Liebau, Eva; Peppler, Carolin; Raue, Katharina; Werne, Steffen; Strube, Christina; Heckendorn, Felix; Agyare, Christian; Stark, Timo; Hofmann, Thomas; Hensel, Andreas

    2016-08-01

    Paullinia pinnata is a medicinal plant traditionally used in West Africa against a wide range of diseases including soil-transmitted helminthiases. In this study, a hydroethanolic root extract was investigated for its phytochemical composition and in vitro activity against the free-living nematode Caenorhabditis elegans as well as the larval stages of the parasitic helminths Ancylostoma caninum, Haemonchus contortus, Toxocara cati, and Trichuris vulpis.LC-MS analysis of the ethanol-water (1 : 1) extract revealed epicatechin and different A-type linked oligomeric and polymeric procyanidins as the predominant compounds.Within an in vitro mortality assay, the extract showed a lethal activity against T. cati (LC50 of 112 µg/mL), T. vulpis (LC50 of 17 µg/mL), and C. elegans (LC50 2.5 of mg/mL), but not against A. caninum. Additionally, effects on egg hatching and larval migration of H. contortus were investigated, but no inhibitory activity was observed.Overall, these findings rationalize the traditional use of the root extract from P. pinnata as an anthelmintic remedy and provide insight into the phytochemical composition of the extract. Georg Thieme Verlag KG Stuttgart · New York.

  18. Antimicrobial Resistance Genes in Pigeons from Public Parks in Costa Rica.

    PubMed

    Blanco-Peña, K; Esperón, F; Torres-Mejía, A M; de la Torre, A; de la Cruz, E; Jiménez-Soto, M

    2017-02-24

    Antimicrobial resistance is known to be an emerging problem, but the extent of the issue remains incomplete. The aim of this study was to determine the presence or absence of nine resistance genes (blaTEM , catI, mecA, qnrS, sulI, sulII, tet(A), tet(Q), vanA) in the faeces of 141 pigeons from four urban parks in Alajuela, Guadalupe, Tres Ríos and San José in Costa Rica. The genes were identified by real-time PCR directly from enema samples. About 30% of the samples were positive for genes catI and sulI; between 13% and 17% were positive for qnrS, sulII, tet(A) and tet(Q); and 4% were positive for blaTEM . The mecA and vanA genes were not detected. The average of antimicrobial resistance genes detected per pigeon was 2. Eight different patterns of resistance were identified, without differences in the sampling areas, being the most common pattern 2 (sulII positive samples). During rainy season, the genes more frequently found were sulI and tet(A). In conclusion, the urban inhabiting pigeons tested are currently carrying antimicrobial resistance genes, potentially acting as reservoirs of resistant bacteria and vectors to humans. To the authors' knowledge, this is the first study carried out on direct detection of resistance genes in the digestive metagenomes of pigeons.

  19. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.

    PubMed

    Chen, X; Lee, G; Maher, B S; Fanous, A H; Chen, J; Zhao, Z; Guo, A; van den Oord, E; Sullivan, P F; Shi, J; Levinson, D F; Gejman, P V; Sanders, A; Duan, J; Owen, M J; Craddock, N J; O'Donovan, M C; Blackman, J; Lewis, D; Kirov, G K; Qin, W; Schwab, S; Wildenauer, D; Chowdari, K; Nimgaonkar, V; Straub, R E; Weinberger, D R; O'Neill, F A; Walsh, D; Bronstein, M; Darvasi, A; Lencz, T; Malhotra, A K; Rujescu, D; Giegling, I; Werge, T; Hansen, T; Ingason, A; Nöethen, M M; Rietschel, M; Cichon, S; Djurovic, S; Andreassen, O A; Cantor, R M; Ophoff, R; Corvin, A; Morris, D W; Gill, M; Pato, C N; Pato, M T; Macedo, A; Gurling, H M D; McQuillin, A; Pimm, J; Hultman, C; Lichtenstein, P; Sklar, P; Purcell, S M; Scolnick, E; St Clair, D; Blackwood, D H R; Kendler, K S

    2011-11-01

    We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association information network (MGS-GAIN) schizophrenia data sets and performed bioinformatic prioritization for all the markers with P-values ≤0.05 in both data sets. In this process, we found that in the CMYA5 gene, there were two non-synonymous markers, rs3828611 and rs10043986, showing nominal significance in both the CATIE and MGS-GAIN samples. In a combined analysis of both the CATIE and MGS-GAIN samples, rs4704591 was identified as the most significant marker in the gene. Linkage disequilibrium analyses indicated that these markers were in low LD (3 828 611-rs10043986, r(2)=0.008; rs10043986-rs4704591, r(2)=0.204). In addition, CMYA5 was reported to be physically interacting with the DTNBP1 gene, a promising candidate for schizophrenia, suggesting that CMYA5 may be involved in the same biological pathway and process. On the basis of this information, we performed replication studies for these three single-nucleotide polymorphisms. The rs3828611 was found to have conflicting results in our Irish samples and was dropped out without further investigation. The other two markers were verified in 23 other independent data sets. In a meta-analysis of all 23 replication samples (family samples, 912 families with 4160 subjects; case-control samples, 11 380 cases and 15 021 controls), we found that both markers are significantly associated with schizophrenia (rs10043986, odds ratio (OR)=1.11, 95% confidence interval (CI)=1.04-1.18, P=8.2 × 10(-4) and rs4704591, OR=1.07, 95% CI=1.03-1.11, P=3.0 × 10(-4)). The results were also significant for the 22 Caucasian replication samples (rs10043986, OR=1.11, 95% CI=1.03-1.17, P=0.0026 and rs4704591, OR=1.07, 95% CI=1.02-1.11, P=0.0015). Furthermore, haplotype conditioned analyses indicated that the association

  20. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

    PubMed Central

    Chen, X; Lee, G; Maher, BS; Fanous, AH; Chen, J; Zhao, Z; Guo, A; van den Oord, E; Sullivan, PF; Shi, J; Levinson, DF; Gejman, PV; Sanders, A; Duan, J; Owen, MJ; Craddock, NJ; O’Donovan, MC; Blackman, J; Lewis, D; Kirov, GK; Qin, W; Schwab, S; Wildenauer, D; Chowdari, K; Nimgaonkar, V; Straub, RE; Weinberger, DR; O’Neill, FA; Walsh, D; Bronstein, M; Darvasi, A; Lencz, T; Malhotra, AK; Rujescu, D; Giegling, I; Werge, T; Hansen, T; Ingason, A; Nöethen, MM; Rietschel, M; Cichon, S; Djurovic, S; Andreassen, OA; Cantor, RM; Ophoff, R; Corvin, A; Morris, DW; Gill, M; Pato, CN; Pato, MT; Macedo, A; Gurling, HMD; McQuillin, A; Pimm, J; Hultman, C; Lichtenstein, P; Sklar, P; Purcell, SM; Scolnick, E; St Clair, D; Blackwood, DHR; Kendler, KS

    2012-01-01

    We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association information network (MGS-GAIN) schizophrenia data sets and performed bioinformatic prioritization for all the markers with P-values ≤0.05 in both data sets. In this process, we found that in the CMYA5 gene, there were two non-synonymous markers, rs3828611 and rs10043986, showing nominal significance in both the CATIE and MGS-GAIN samples. In a combined analysis of both the CATIE and MGS-GAIN samples, rs4704591 was identified as the most significant marker in the gene. Linkage disequilibrium analyses indicated that these markers were in low LD (3 828 611–rs10043986, r2 = 0.008; rs10043986–rs4704591, r2 = 0.204). In addition, CMYA5 was reported to be physically interacting with the DTNBP1 gene, a promising candidate for schizophrenia, suggesting that CMYA5 may be involved in the same biological pathway and process. On the basis of this information, we performed replication studies for these three single-nucleotide polymorphisms. The rs3828611 was found to have conflicting results in our Irish samples and was dropped out without further investigation. The other two markers were verified in 23 other independent data sets. In a meta-analysis of all 23 replication samples (family samples, 912 families with 4160 subjects; case–control samples, 11 380 cases and 15 021 controls), we found that both markers are significantly associated with schizophrenia (rs10043986, odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.04–1.18, P = 8.2 × 10−4 and rs4704591, OR = 1.07, 95% CI = 1.03–1.11, P = 3.0 × 10−4). The results were also significant for the 22 Caucasian replication samples (rs10043986, OR = 1.11, 95% CI = 1.03–1.17, P = 0.0026 and rs4704591, OR = 1.07, 95% CI = 1.02–1.11, P = 0.0015). Furthermore, haplotype conditioned analyses

  1. Does Computer Survey Technology Improve Reports on Alcohol and Illicit Drug Use in the General Population? A Comparison Between Two Surveys with Different Data Collection Modes In France

    PubMed Central

    Beck, François; Guignard, Romain; Legleye, Stéphane

    2014-01-01

    Background Previous studies have shown that survey methodology can greatly influence prevalence estimates for alcohol and illicit drug use. The aim of this article is to assess the effect of data collection modes on alcohol misuse and drug use reports by comparing national estimates from computer-assisted telephone interviews (CATI) and audio-computer-assisted self interviews (A-CASI). Methods Design: Two national representative surveys conducted in 2005 in France by CATI (n = 24,674) and A-CASI (n = 8,111). Participants: French-speaking individuals aged [18]–[64] years old. Measurements: Alcohol misuse according to the CAGE test, cannabis use (lifetime, last year, 10+ in last month) and experimentation with cocaine, LSD, heroin, amphetamines, ecstasy, were measured with the same questions and wordings in the two surveys. Multivariate logistic regressions controlling for sociodemographic characteristics (age, educational level, marital status and professional status) were performed. Analyses were conducted on the whole sample and stratified by age (18–29 and 30–44 years old) and gender. 45–64 years old data were not analysed due to limited numbers. Results Overall national estimates were similar for 9 out of the 10 examined measures. However, after adjustment, A-CASI provided higher use for most types of illicit drugs among the youngest men (adjusted odds ratio, or OR, of 1.64 [1.08–2.49] for cocaine, 1.62 [1.10–2.38] for ecstasy, 1.99 [1.17–3.37] for LSD, 2.17 [1.07–4.43] for heroin, and 2.48 [1.41–4.35] for amphetamines), whereas use amongst women was similar in CATI and A-CASI, except for LSD in the 30–44 age group (OR = 3.60 [1.64–7.89]). Reported alcohol misuse was higher with A-CASI, for all ages and genders. Conclusions Although differences in the results over the whole population were relatively small between the surveys, the effect of data collection mode seemed to vary according to age and gender. PMID:24465720

  2. Utility of telephone survey methods in population-based health studies of older adults: an example from the Alberta Older Adult Health Behavior (ALERT) study.

    PubMed

    Vallance, Jeff K; Eurich, Dean T; Gardiner, Paul A; Taylor, Lorian M; Stevens, Gillian; Johnson, Steven T

    2014-05-22

    Random digit dialing is often used in public health research initiatives to accrue and establish a study sample; however few studies have fully described the utility of this approach. The primary objective of this paper was to describe the implementation and utility of using random digit dialing and Computer Assisted Telephone Interviewing (CATI) for sampling, recruitment and data collection in a large population-based study of older adults [Alberta Older Adult Health Behavior (ALERT) study]. Using random digit dialing, older adults (> = 55 years) completed health behavior and outcome and demographic measures via CATI. After completing the CATI, participants were invited to receive a step pedometer and waist circumference tape measure via mail to gather objectively derived ambulatory activity and waist circumference assessments. Overall, 36,000 telephone numbers were called of which 7,013 were deemed eligible for the study. Of those, 4,913 (70.1%) refused to participate in the study and 804 (11.4%) participants were not included due to a variety of call dispositions (e.g., difficult to reach, full quota for region). A total of 1,296 participants completed telephone interviews (18.5% of those eligible and 3.6% of all individuals approached). Overall, 22.8% of households did not have an age 55+ resident and 13.6% of individuals refused to participate, Average age was 66.5 years, and 43% were male. A total of 1,081 participants (83.4%) also submitted self-measured ambulatory activity (i.e., via step pedometer) and anthropometric data (i.e., waist circumference). With the exception of income (18.7%), the rate of missing data for demographics, health behaviors, and health measures was minimal (<1%). Older adults are willing to participate in telephone-based health surveys when randomly contacted. Researchers can use this information to evaluate the feasibility and the logistics of planned studies using a similar population and study design.

  3. Building the Evidence Base for Remote Data Collection in Low- and Middle-Income Countries: Comparing Reliability and Accuracy Across Survey Modalities.

    PubMed

    Greenleaf, Abigail R; Gibson, Dustin G; Khattar, Christelle; Labrique, Alain B; Pariyo, George W

    2017-05-05

    Given the growing interest in mobile data collection due to the proliferation of mobile phone ownership and network coverage in low- and middle-income countries (LMICs), we synthesized the evidence comparing estimates of health outcomes from multiple modes of data collection. In particular, we reviewed studies that compared a mode of remote data collection with at least one other mode of data collection to identify mode effects and areas for further research. The study systematically reviewed and summarized the findings from articles and reports that compare a mode of remote data collection to at least one other mode. The aim of this synthesis was to assess the reliability and accuracy of results. Seven online databases were systematically searched for primary and grey literature pertaining to remote data collection in LMICs. Remote data collection included interactive voice response (IVR), computer-assisted telephone interviews (CATI), short message service (SMS), self-administered questionnaires (SAQ), and Web surveys. Two authors of this study reviewed the abstracts to identify articles which met the primary inclusion criteria. These criteria required that the survey collected the data from the respondent via mobile phone or landline. Articles that met the primary screening criteria were read in full and were screened using secondary inclusion criteria. The four secondary inclusion criteria were that two or more modes of data collection were compared, at least one mode of data collection in the study was a mobile phone survey, the study had to be conducted in a LMIC, and finally, the study should include a health component. Of the 11,568 articles screened, 10 articles were included in this study. Seven distinct modes of remote data collection were identified: CATI, SMS (singular sitting and modular design), IVR, SAQ, and Web surveys (mobile phone and personal computer). CATI was the most frequent remote mode (n=5 articles). Of the three in-person modes (face

  4. Occurrence and clinical significance of Aelurostrongylus abstrusus and other endoparasites in Danish cats.

    PubMed

    Hansen, Alice P; Skarbye, Line K; Vinther, Lene M; Willesen, Jakob L; Pipper, Christian B; Olsen, Caroline S; Mejer, Helena

    2017-01-30

    Feline endoparasites are highly prevalent worldwide and may cause a variety of clinical signs in infected cats. Prevalence rates are dynamic and there is limited knowledge of the current prevalence in Denmark and the clinical manifestation and significance of especially the lungworm Aelurostrongylus abstrusus. This study investigated the total and local prevalence of Aelurostrongylus abstrusus and other endoparasites in Danish cats. The clinical significance of feline aelurostrongylosis was also examined through identification of frequency and severity of selected clinical signs. Faecal samples (n=327) and clinical data (n=312) were collected from August to October 2015, primarily from outdoor cats located at shelters distributed across Denmark. A modified Baermann method and a concentration McMaster technique was used to diagnose A. abstrusus first stage larvae and eggs/oocysts of other endoparasites. The total A. abstrusus prevalence was 8.3% [95% CI: 5.6-11.9] but local prevalence rates varied from 0% [95% CI: 0.0-8.8] to 31.4% [95% CI: 16.9-49.3]. A rural habitat appeared to increase the risk of A. abstrusus and this accounted for most of the local variation. Furthermore, the risk of infection was lower in kittens younger than 11 weeks compared to older cats (p=0.002). The cats were also infected with Toxocara cati (44.4% [95% CI: 38.3-50.7]), taeniid species (8.9% [95% CI: 5.7-13.0]), Capillaria aerophila (3.1% [95% CI: 1.3-6.0]), Aonchotheca putorii (3.9% [95% CI: 1.9-7.0]), Cystoisospora felis (3.1% [95% CI: 1.3-6.0]) and Cystoisospora rivolta (2.3% [95% CI: 0.9-5.0]), but there was no difference in local distribution. Co-infection was common, as 66.7% of A. abstrusus infected cats were also infected with one or more other parasites, the most common being T. cati. However, none of these parasites were significantly associated with A. abstrusus. The vast majority of the A. abstrusus infected cats displayed mild to moderate clinical signs. The main symptoms

  5. Homomorphisms between C*-algebras and linear derivations on C*-algebras

    NASA Astrophysics Data System (ADS)

    Park, Choonkil; Boo, Deok-Hoon; An, Jong Su

    2008-01-01

    It is shown that every almost unital almost linear mapping of a unital C*-algebra to a unital C*-algebra is a homomorphism when h(3nuy)=h(3nu)h(y) holds for all unitaries , all , and all , and that every almost unital almost linear continuous mapping of a unital C*-algebra of real rank zero to a unital C*-algebra is a homomorphism when h(3nuy)=h(3nu)h(y) holds for all , and v is invertible}, all , and all . Furthermore, we prove the Hyers-Ulam-Rassias stability of *-homomorphisms between unital C*-algebras, and -linear *-derivations on unital C*-algebras. The concept of Hyers-Ulam-Rassias stability originated from the Th.M. Rassias' stability theorem that appeared in his paper: On the stability of the linear mapping in Banach spaces, Proc. Amer. Math. Soc. 72 (1978) 297-300.

  6. Singular Instantons and Painlevé VI

    NASA Astrophysics Data System (ADS)

    Muñiz Manasliski, Richard

    2016-06-01

    We consider a two parameter family of instantons, which is studied in [Sadun L., Comm. Math. Phys. 163 (1994), 257-291], invariant under the irreducible action of SU_2 on S^4, but which are not globally defined. We will see that these instantons produce solutions to a one parameter family of Painlevé VI equations (P_VI}) and we will give an explicit expression of the map between instantons and solutions to P_{VI}. The solutions are algebraic only for that values of the parameters which correspond to the instantons that can be extended to all of S^4. This work is a generalization of [Muñiz Manasliski R., Contemp. Math., Vol. 434, Amer. Math. Soc., Providence, RI, 2007, 215-222] and [Muñiz Manasliski R., J. Geom. Phys. 59 (2009), 1036-1047, arXiv:1602.07221], where instantons without singularities are studied.

  7. The origin of cellular life

    NASA Technical Reports Server (NTRS)

    Ingber, D. E.

    2000-01-01

    This essay presents a scenario of the origin of life that is based on analysis of biological architecture and mechanical design at the microstructural level. My thesis is that the same architectural and energetic constraints that shape cells today also guided the evolution of the first cells and that the molecular scaffolds that support solid-phase biochemistry in modern cells represent living microfossils of past life forms. This concept emerged from the discovery that cells mechanically stabilize themselves using tensegrity architecture and that these same building rules guide hierarchical self-assembly at all size scales (Sci. Amer 278:48-57;1998). When combined with other fundamental design principles (e.g., energy minimization, topological constraints, structural hierarchies, autocatalytic sets, solid-state biochemistry), tensegrity provides a physical basis to explain how atomic and molecular elements progressively self-assembled to create hierarchical structures with increasingly complex functions, including living cells that can self-reproduce.

  8. Simulations of the 2.5D inviscid primitive equations in a limited domain

    NASA Astrophysics Data System (ADS)

    Chen, Qingshan; Temam, Roger; Tribbia, Joseph J.

    2008-12-01

    The primitive equations (PEs) of the atmosphere and the oceans without viscosity are considered. These equations are not well-posed for any set of local boundary conditions. In space dimension 2.5 a set of nonlocal boundary conditions has been proposed in Chen et al. [Q. Chen, J. Laminie, A. Rousseau, R. Temam, J. Tribbia, A 2.5D Model for the equations of the ocean and the atmosphere, Anal. Appl. 5(3) (2007) 199-229]. The present article is aimed at testing the validity of these boundary conditions with physically relevant data. The issues tested are the well-posedness in the nonlinear case and the computational efficiency of the boundary conditions for limited area models [T.T. Warner, R.A. Peterson, R.E. Treadon, A tutorial on lateral boundary conditions as a basic and potentially serious limitation to regional numerical weather prediction, Bull. Amer. Meteor. Soc. 78(11) (1997) 2599-2617].

  9. Purification and Partial Characterization of a Glucan Containing Indole-3-acetic Acid 1

    PubMed Central

    Piskornik, Zdzislaw; Bandurski, Robert S.

    1972-01-01

    The “bound auxin” of Zea mays, first described by Berger and Avery (Amer. J. Bot. 1944; 31: 199-203) has been purified and partially characterized. It is an indole-3-acetic acid-containing, high molecular weight, lipophilic cellulosicglucan. The indole-3-acetic acid is in ester linkage as evidenced by indoleacetamide formation upon ammonolysis. The glucan is of variable chain length and comprises, in general, 35 to 50 per cent of the dry weight of the compound. The glucosidic residues are β 1 → 4 linked and are hydrolyzed by cellulase. Mild acid hydrolysis produces cellobiose and cellotriose. Other components, as yet unidentified, of the compound are described. PMID:16658117

  10. Formulating tightest bounds on causal effects in studies with unmeasured confounders.

    PubMed

    Kuroki, Manabu; Cai, Zhihong

    2008-12-30

    This paper considers the problem of evaluating the causal effect of an exposure on an outcome in observational studies with both measured and unmeasured confounders between the exposure and the outcome. Under such a situation, MacLehose et al. (Epidemiology 2005; 16:548-555) applied linear programming optimization software to find the minimum and maximum possible values of the causal effect for specific numerical data. In this paper, we apply the symbolic Balke-Pearl linear programming method (Probabilistic counterfactuals: semantics, computation, and applications. Ph.D. Thesis, UCLA Cognitive Systems Laboratory, 1995; J. Amer. Statist. Assoc. 1997; 92:1172-1176) to derive the simple closed-form expressions for the lower and upper bounds on causal effects under various assumptions of monotonicity. These universal bounds enable epidemiologists and medical researchers to assess causal effects from observed data with minimum computational effort, and they further shed light on the accuracy of the assessment. Copyright 2008 John Wiley & Sons, Ltd.

  11. An aquarium experiment on the American eel as a predator on larval lampreys

    USGS Publications Warehouse

    Perlmutter, Alfred

    1951-01-01

    The parasitic sea lamprey, Petromyzon marinus, has in recent years spread throughout Lakes Huron and Michigan and is now firmly established in these waters (Applegate, 1949, Mich. Cons., 18 (4): 13-15). Coincident with their spread, the abundance of lake trout, Salvelinus namaycush, has declined in both lakes (Hile, 1949, Trans. Amer. Fish. Soc., 76 (1946): 121-147) and the lake trout as well as other species of fishes are showing an increase in scarring from lamprey attacks. For Lake Michigan the analysis of fishermen's questionnaires gave an increase in percentage by weight of lamprey-scarred lake trout from 31 percent in 1947 to 41 percent in 1948. The sea lamprey is now spreading through Lake Superior, the last of the Great Lakes containing a large population of lake trout.

  12. Bifurcation and global periodic solutions in a delayed facultative mutualism system

    NASA Astrophysics Data System (ADS)

    Yan, Xiang-Ping; Li, Wan-Tong

    2007-03-01

    A facultative mutualism system with a discrete delay is considered. By analyzing the associated characteristic equation, its linear stability is investigated and Hopf bifurcations are demonstrated. Some explicit formulae are obtained by applying the normal form theory and center manifold reduction. Such formulae enable us to determine the stability and the direction of the bifurcating periodic solutions bifurcating from Hopf bifurcations. Furthermore, a global Hopf bifurcation result due to Wu [J. Wu, Symmetric functional differential equations and neural networks with memory, Trans. Amer. Math. Soc. 350 (1998) 4799-4838] is employed to study the global existence of periodic solutions. It is shown that the local Hopf bifurcation implies the global Hopf bifurcation after the third critical value τ1(1) of delay. Finally, numerical simulations supporting the theoretical analysis are given.

  13. Synthesis of Fluorinated Acetylenes.

    DTIC Science & Technology

    1982-03-01

    Systems Cancer Globe Union lacor-porated Now London, Conecticut %06320L 5757 Sorth Green 3ay Avenue 1l.wukae, Wi.sconsin 33201 1 Dr., Wiliam Uisen...1 1 1472-31M472:GWs: :. i 78S472-600 Off of y a ewch V*. "Ay ieoerch Office , teas Code 472 J zAn: RD-A-IP m A b’fA oim ss |l t P.0. Bo 1211 Alrgtt... Green Stowe 61n Dieo, Calorni 921S2 Sasadeus, C.alfouni 9106 1aval. Weapons Center o tern m l Office hIt: Dr. A. ’. Amer, Almas D.. Plebles Chmstry

  14. Fixed-point theorems for families of weakly non-expansive maps

    NASA Astrophysics Data System (ADS)

    Mai, Jie-Hua; Liu, Xin-He

    2007-10-01

    In this paper, we present some fixed-point theorems for families of weakly non-expansive maps under some relatively weaker and more general conditions. Our results generalize and improve several results due to Jungck [G. Jungck, Fixed points via a generalized local commutativity, Int. J. Math. Math. Sci. 25 (8) (2001) 497-507], Jachymski [J. Jachymski, A generalization of the theorem by Rhoades and Watson for contractive type mappings, Math. Japon. 38 (6) (1993) 1095-1102], Guo [C. Guo, An extension of fixed point theorem of Krasnoselski, Chinese J. Math. (P.O.C.) 21 (1) (1993) 13-20], Rhoades [B.E. Rhoades, A comparison of various definitions of contractive mappings, Trans. Amer. Math. Soc. 226 (1977) 257-290], and others.

  15. Bronzed cowbird taken in Florida

    USGS Publications Warehouse

    Matteson, R.E.

    1970-01-01

    On 8 November 1968 in Gainesville, Florida, I removed a male Bronzed Cowbird (Tangavius a. aeneus) from a blackbird decoy trap containing a large number of Brown-headed Cowbirds (Malothrus ater). Oliver L. Austin, Jr., at the Florida State Museum, verified the species identification by noting the notched inner webs of the outer three primaries, a characteristic of the genus. The subspecific identification was made at the U. S. National Museum where the bird is now specimen number 531666. The subspecies normally ranges from southcentral Texas and the Yucatan Peninsula south through Central America to Panama (Check-list of North American birds, fifth ed., Baltimore, Amer. Ornithol. Union, 1957, p. 542). This Gainesville specimen apparently is the first Bronzed Cow- bird taken in Florida. Alexander Sprunt, Jr., (Florida bird life. In Addendum to Florida bird life, New York, Coward-McCann, 1963, p. 18) lists three photographed sightings at Sarasota, Florida, in April 196

  16. Dimer statistics on the Klein bottle

    NASA Astrophysics Data System (ADS)

    Lu, Fuliang; Zhang, Lianzhu; Lin, Fenggen

    2011-06-01

    The problem of enumerating close-packed dimers, or perfect matchings, on a quadratic lattice embedded on the Klein bottle is considered. Thomassen [C. Thomassen, Tilings of the torus and the Klein Bottle and vertex-transitive graphs on a fixed surface, Trans. Amer. Math. Soc. 323(2) (1991) 605-635] characterized that there are six quadrilateral lattices embedded on the Klein bottle. Lu and Wu [W. T. Lu and F. Y. Wu, Close-packed dimers on nonorientable surfaces, Phys. Lett. A 293 (2002) 235-246] had obtained a expression for the number of close-packed dimers on one of them. In this paper we investigate four other embeddings and obtain explicit expressions of the numbers of close-packed dimers and free energy per dimer by enumerating Pfaffians.

  17. Nonlinear geochemical dynamics and petrography: Burial dolomitization (Invited)

    NASA Astrophysics Data System (ADS)

    Merino, E.

    2010-12-01

    both the formation of self-organized syntaxial zebra veins [4,9] hosted by the replacive dolomite, and the curving of the displacive (“saddle”) dolomite crystals, precisely as observed petrographically. The model also explains why dolomitization affects only limestones and why MVT Pb and Zn ores are hosted in dolostones. [1] Merino (1984), in Nicolis & Baras, eds., Chemical Instabilities, NATO Adv. Sci. Series C 120, 305-328. [2] Merino, Wang (2001) in H.J. Krug & J.H. Kruhl, eds., Non-Equilibrium Processes in Geoscience, Self-Organization Yearbook 11, 13-45 (Dunker Humblot) [3] Ortoleva et al (1982) Amer J Sci 282, 617-643. [4] Merino et al (2006) Geologica Acta 4, 383-393. [5] Merino et al (1983) Contrib Min. Petrol. 82, 360-370. [6] Haase et al (1980) Science 209, 272-274; Wang, Merino (1992) GCActa 56, 587-596. [7] Merino, Banerjee (2008) J. Geology 116, 62-75. [8] Wang et al (2009) Nature-Geoscience 2, 781-784. [9] Merino, Canals (2010) Dynamics of dolomitization, Amer J Sci, submitted. [10] Wilson et al (2001) Amer J Sci 301, 727-752; Caspard et al (2004) Geofluids 4, 40-60; Whittaker et al (2004) in Braithwaite et al, eds., Geometry and Petrogenesis of Dolomite Hydrocarbon Reservoirs, Geol Soc London, Spec Publ 235, 99-139; Jones, Xiao (2005) Amer Assoc Petroleum Geologists bull. 89, 577-601.

  18. Polymer wear and its control

    SciTech Connect

    Lee, L.H.

    1985-01-01

    Recent advances in polymer (P) tribology are discussed in reviews and reports based on contributions to a symposium held by the Division of Polymeric Materials Science and Engineering of the Americal Chemical Society in St. Louis in spring 1984. Topics examined are mechanisms of P wear, controls of P wear, the tribological behavior of Ps, wear of biomaterials and P composites, characterization and measurements of P wear, and degradation and wear of polymeric films and filaments. Consideration is given to the fracture and surface energetics of P wear, fatigue-abrasive mechanisms of P wear, plasma modification of P surfaces, the wear characteristics of articular cartilage, the role of fillers in the wear of high-density polyethylene, the tribology of fiber-reinforced polyimides sliding against steel and Si3N4, laboratory and in-service wear tests of Ps, and the effect of degree of crystallinity on wear of poly(ethylene terephthalate).

  19. A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. | Office of Cancer Genomics

    Cancer.gov

    We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing of 651 Wilms tumors. In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR, BCORL1, NONO, MAX, COL6A3, ASXL1, MAP3K4, and ARID1A.

  20. The Untied States and Vietnam: 1975-1987

    DTIC Science & Technology

    1987-01-01

    c1 a milit~rv ~ctticn mounted in disr~i~ ~o ~ 1 h~~· th•t th• dissclution ot SEATO and the withdr•wal 1rom T~~il~~d eoul~ b• •ccompl~•hed i~ w•ys...lion tc. the Thai government to support the development or longer-term plans ror refu-ee resettlement. Mounting numbers attracted increasin:jy...tryinS to sieer something or a middle course between Cambola.z an~d Vi etna -m. wEre, convey ing t o Amer Ican interlIoccutorr suppor t t or US- A V

  1. Isomonodromic deformations and SU 2-invariant instantons on S4

    NASA Astrophysics Data System (ADS)

    Manasliski, Richard Muñiz

    2009-07-01

    Anti-self-dual (ASD) solutions to the Yang-Mills equation (or instantons) over an anti-self-dual 4-manifold, which are invariant under an appropriate action of a three-dimensional Lie group, give rise, via twistor construction, to isomonodromic deformations of connections on CP having four simple singularities. As is well known, such deformations are governed by the sixth Painlevé equation P VI(α,β,γ,δ). We work out the particular case of the SU-action on S4, obtained from the irreducible representation on R5. In particular, we express the parameters (α,β,γ,δ) in terms of the instanton number. The present paper contains the proof of the result announced in [Richard Muñiz Manasliski, Painlevé VI equation from invariant instantons, in: Geometric and Topological Methods for Quantum field theory, Contemp. Math., vol. 434, Amer. Math. Soc., Providence, RI, 2007, pp. 215-222].

  2. Schaefer type theorem and periodic solutions of evolution equations

    NASA Astrophysics Data System (ADS)

    Liu, Yicheng; Li, Zhixiang

    2006-04-01

    Two fixed point theorems for the sum of contractive and compact operators are obtained in this paper, which generalize and improve the corresponding results in [H. Schaefer, Uber die methode der a priori-Schranken, Math. Ann. 129 (1955) 415-416; T.A. Burton, Integral equations, implicit functions and fixed points, Proc. Amer. Math. Soc. 124 (1996) 2383-2390; V.I. Istratescu, Fixed Point Theory, an Introduction, Reidel, Dordrecht, 1981; T.A. Burton, K. Colleen, A fixed point theorem of Krasnoselskii-Schaefer type, Math. Nachr. 189 (1998) 23-31; D.R. Smart, Fixed Point Theorems, Cambridge Univ. Press, Cambridge, 1980]. As the applications for the results, we obtain the existence of periodic solutions for some evolution equations with delay, which extend the corresponding results in [T.A. Burton, B. Zhang, Periodic solutions of abstract differential equations with infinite delay, J. Differential Equations 90 (1991) 357-396].

  3. Compactly supported tight wavelet frames and orthonormal wavelets of exponential decay with a general dilation matrix

    NASA Astrophysics Data System (ADS)

    Han, Bin

    2003-06-01

    Tight wavelet frames and orthonormal wavelet bases with a general dilation matrix have applications in many areas. In this paper, for any d×d dilation matrix M, we demonstrate in a constructive way that we can construct compactly supported tight M-wavelet frames and orthonormal M-wavelet bases in of exponential decay, which are derived from compactly supported M-refinable functions, such that they can have both arbitrarily high smoothness and any preassigned order of vanishing moments. This paper improves several results in Battle (Comm. Math. Phys. 110 (1987) 601), Bownik (J. Fourier Anal. Appl. 7(2001) 489), Gröchenig and Ron (Proc. Amer. Math. Soc. 126 (1998) 1101), Lemarie (J. Math. Pures Appl. 67 (1988) 227), and Strichartz (Constr. Approx. 9 (1993) 327).

  4. The origin of cellular life

    NASA Technical Reports Server (NTRS)

    Ingber, D. E.

    2000-01-01

    This essay presents a scenario of the origin of life that is based on analysis of biological architecture and mechanical design at the microstructural level. My thesis is that the same architectural and energetic constraints that shape cells today also guided the evolution of the first cells and that the molecular scaffolds that support solid-phase biochemistry in modern cells represent living microfossils of past life forms. This concept emerged from the discovery that cells mechanically stabilize themselves using tensegrity architecture and that these same building rules guide hierarchical self-assembly at all size scales (Sci. Amer 278:48-57;1998). When combined with other fundamental design principles (e.g., energy minimization, topological constraints, structural hierarchies, autocatalytic sets, solid-state biochemistry), tensegrity provides a physical basis to explain how atomic and molecular elements progressively self-assembled to create hierarchical structures with increasingly complex functions, including living cells that can self-reproduce.

  5. Interview with Philip W. Anderson

    SciTech Connect

    Anderson, P.W.

    1988-08-01

    Phil Anderson, Professor of Physics at Princeton University, has devoted his career to research in theoretical physics. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, a foreign member of the Royal Society, and a foreign associate of the Accademia Lincei in Rome. The Americal Physical Society awarded him the Oliver E. Buckley Solid State Physics Prize in 1964. In 1977 he won the Nobel Prize in Physics with J.H. van Vleck and N.F. Mott. His work has encompassed a broad range of subjects: quantum theory of condensed matter, broken symmetry, transport theory and localization, random statistical systems, spectral line broadening, superfluidity in helium and neutron stars, magnetism, and superconductivity. His avocations include ''hiking, the game of GO, Romanesque architecture, and the human condition.'' In this interview he explains his RVB theory of the oxide superconductors and its historical context.

  6. Rigid HYM Connections on Tautological Bundles over ALE Crepant Resolutions in Dimension Three

    NASA Astrophysics Data System (ADS)

    Degeratu, Anda; Walpuski, Thomas

    2016-02-01

    For G a finite subgroup of SL(3,C) acting freely on C^3{setminus} 0 a crepant resolution of the Calabi-Yau orbifold C^3/G always exists and has the geometry of an ALE non-compact manifold. We show that the tautological bundles on these crepant resolutions admit rigid Hermitian-Yang-Mills connections. For this we use analytical information extracted from the derived category McKay correspondence of Bridgeland, King, and Reid [J. Amer. Math. Soc. 14 (2001), 535-554]. As a consequence we rederive multiplicative cohomological identities on the crepant resolution using the Atiyah-Patodi-Singer index theorem. These results are dimension three analogues of Kronheimer and Nakajima's results [Math. Ann. 288 (1990), 263-307] in dimension two.

  7. Monitoring the bulk milk antibody response to bovine viral diarrhea in dairy herds vaccinated with inactivated vaccines.

    PubMed

    Gonzalez, A M; Arnaiz, I; Eiras, C; Camino, F; Sanjuán, M L; Yus, E; Diéguez, F J

    2014-01-01

    This study was designed to determine long-term responses in dairy herds after vaccination with 1 of 3 inactivated bovine viral diarrhea virus (BVDV) vaccines with regard to antibodies against p80 protein in bulk tank milk samples, as detected by ELISA. In the present study, 29 dairy herds were vaccinated with Bovilis BVD (MSD Animal Health, Milton Keynes, UK), 11 with Hiprabovis Balance (Laboratorios Hipra, Amer, Spain), and 9 with Pregsure BVD (Zoetis, Florham Park, NJ). In these herds, bulk tank milk samples were collected and examined at the time of the first vaccination and every 6 mo during a 3-yr period. Samples were analyzed with a commercial ELISA test for the p80 protein of BVDV. The results demonstrated that vaccination affected the level of antibodies against p80. Hence, vaccination status should be taken into consideration when interpreting bulk tank milk antibody tests.

  8. Vulnerability Evaluation of the Keyworker Blast Shelter

    DTIC Science & Technology

    1987-04-01

    of approximately 0.002 in the roof, walls, and floor. 11. Americ; rt Society for Testing and Materials ( ASTM ) Grade 60 reinforc- ing steel. 12...shelter called for ASTM Grade 60 reinforcing steel and 3,000-psi concrete (combressive atrength at 28 days). Based on tensile tests on seven random...ur 2 1 Flou r pl n nd e va o . A 9 XIA a 2"FA ’¶v. 41’ .1 10 I I DIRECTION OF DETONATION v1 "I0 I ’ E18 r-SE1lroeSI 2 ’+-SE26 S SE 321 -sE30 - r 4

  9. Further localization of the gene for nevoid basal cell carcinoma syndrome (NBCCS) in 15 Australasian families: Linkage and loss of heterozygosity

    SciTech Connect

    Chenevix-Trench, G.; Wicking, C.; Berkman, J.; Sharpe, H.; Hockey, A.; Haan, E.; Oley, C.; Ravine, D.; Turner, A.; Searle, J.

    1993-09-01

    Nevoid basal cell carcinoma syndrome (NBCCS; basal cell nevus syndrome or Gorlin syndrome) is a cancer-predisposition syndrome characterized by multiple basal cell carcinomas (BCCs) and diverse developmental defects. The gene for NBCCS has been mapped to 9q23.1-q31 in North Americal and European families. In addition, loss of heterozygosity (LOH) for genetic markers in this region has been detected in sporadic BCCs, indicating that the NBCCs gene is probably a tumor-suppressor gene. In this study the authors have determined that the NBCCS gene is also linked to this region in Australasian pedigrees and that there is no significant evidence of heterogeneity. They have defined the localization of the gene by multipoint and haplotype analysis of 15 families, using four microsatellite markers. LOH at these loci was detected in 50% of sporadic BCCs, a rate that is significantly higher than that in other skin lesions used as controls. 21 refs., 3 figs., 2 tabs.

  10. A geochemical comparison of alkalic lavas in the Trans-Mexican Volcanic Belt, peninsular Baja California and intraplate volcanoes in the eastern Pacific

    NASA Astrophysics Data System (ADS)

    Tian, L.; Castillo, P. R.

    2011-12-01

    The Trans-Mexican Volcanic Belt (TMVB) is a continental volcanic arc built along the southern edge of the North American plate. The volcanic rocks along TMVB are compositionally diverse and the origin of its alkalic lavas with ocean island basalt (OIB)-like composition is highly controversial. Alkalic lavas from four regions in the western, central, and eastern TMVB [e.g., Verma and Hasenaka, Geochem. J., 58, 2004; Petrone et al., Geol. S. Am. S., 402, 2006; Orozco-Esquivel et al., Geol. Soc. Amer. Bull., 93, 2007] are compared with similar OIB-like alkalic lavas from peninsular Baja California [e.g., Storey et al., Terra Nova, 1, 1989; Castillo, Geol. Soc. Amer. Bull., 120, 2008] and intraplate volcanoes in the eastern Pacific [Tian et al., Geochem. Geophys. Geosyst., 12, 2011] in order to ascertain their geochemical similarities and differences and to constrain the compositions of their respective magma sources. A few of the alkalic lavas from TMVB have very similar trace element and isotopic compositions as the OIB-like alkalic lavas from peninsular Baja California and intraplate volcanoes in the eastern Pacific. Majority of the TMVB alkalic lavas, however, are compositionally more heterogeneous, similar to the less-alkalic Nb-enriched basalts in peninsular Baja California representing OIB-like alkalic lavas that had been contaminated by other mantle components and/or crustal materials. Thus, data seem to indicate that all the OIB-like alkalic lavas can be traced to a similar source, the compositionally heterogeneous Pacific asthenosphere.

  11. Enthalpies of Mixing in Sodium Silicate Glasses and Relevance to Adam-Gibbs Theory

    NASA Astrophysics Data System (ADS)

    Hovis, G.; Jarry, P.; Toplis, M.; Richet, P.

    2003-12-01

    Solution calorimetric measurements have been made in 20.1 wt % hydrofluoric acid at 50° C on binary Na2O-SiO2 glasses ranging in composition from 0 to 50 mol % Na2O. The initial calorimetric data for compositions between 20 and 50 mol % Na2O were highly variable, determined later to be due to the development of Na carbonate on the glass surfaces. However, additional measurements using minimally-ground specimens that had been remelted shortly before the calorimetric dissolutions produced highly reproducible results. After adjustment of the data for glass transition temperature (Richet et al., 1984, J. Amer. Ceram. Soc.), the results show nearly linear ("ideal") behavior of the heats of solution between 50 % Na2O and 30-35 % Na2O. However, positive enthalpies of mixing (Hex) are evident in the compositional region between 0 and 30-35 mol % Na2O, with maximum magnitudes of Hex on the order of 5 kJ/mol relative to 0 and 35 % Na2O end members. Within the framework of the Adam-Gibbs theory of structural relaxation, viscosity and heat capacity data may be combined to determine configurational entropies of silicate glasses. When applied to sodium silicate glasses (Toplis, 2001, Chemical Geology), positive entropies of mixing (Sex) are calculated for compositions between 0 and 30 mole % Na2O, a compositional region where liquid immiscibility also is known to occur (Haller et al., 1974, J. Amer. Ceram. Soc.) and where Gibbs free energies of mixing (Gex) therefore must be positive. Because positive entropies of mixing contribute negatively (-TSex) to Gex, the observed immiscibility requires positive enthalpies of mixing (Hex) in the silicic part of the compositional range. The present study confirms such positive enthalpies of mixing and supports the usefulness of Adam-Gibbs theory for the prediction of viscosity/entropy behavior of silicate glasses and liquids.

  12. Hydrated sulfates on Mars's surface: water cycle and S isotope tracking

    NASA Astrophysics Data System (ADS)

    Caracas, R.; Bobocioiu, E.

    2014-12-01

    We study a range of hydrated sulfate minerals from first-principles calculations based on density-functional and density-functional perturbation theory. We report the results extensively on the WURM website (http://wurm.info, Caracas and Bobcioiu, 2011). We find that hydration has a more pronounced effect on the spectroscopic properties than cation replacement. The Raman spectra of all phases present clear SO4 features that are easily identifiable. We use this to show one can use the vibrational spectroscopic information as an identification tool in a remote environment, like the Martian surface. Based on the computed vibrational results we analyze the S isotope partitioning. We observe that in general hydration favors enrichment in the lighter S isotope 32S with respect to the heavier 34S, which is accumulated in the less hydrous structures. Thus we show for the first time that the signature of 34S/32S partitioning could be observed by in situ spectroscopy on the surface of Mars. Finally we compute hydration energies. For example, in the hydrated magnesium sulfate series we find that epsomite and meridianiite with, respectively 7 and 11 water molecules per MgSO4 unit are particularly stable with respect to other individual or combinations of hydration states (Bobocioiu and Caracas, 2014). This can be related to the diurnal cycle of hydration and dehydration and hence it can improve the modeling of the water circulation on Mars. References: E. Bobocioiu, R. Caracas (2014) Stability and spectroscopy of Mg sulfate minerals. Role of hydration on sulfur isotope partitioning. Amer. Mineral., 99, 1216-1220. R. Caracas, E. Bobocioiu (2011) The WURM project - a freely available web-based repository of computed physical data for minerals. Amer. Mineral. 96, 437-444.

  13. A multiple imputation strategy for sequential multiple assignment randomized trials

    PubMed Central

    Shortreed, Susan M.; Laber, Eric; Stroup, T. Scott; Pineau, Joelle; Murphy, Susan A.

    2014-01-01

    Sequential multiple assignment randomized trials (SMARTs) are increasingly being used to inform clinical and intervention science. In a SMART, each patient is repeatedly randomized over time. Each randomization occurs at a critical decision point in the treatment course. These critical decision points often correspond to milestones in the disease process or other changes in a patient’s health status. Thus, the timing and number of randomizations may vary across patients and depend on evolving patient-specific information. This presents unique challenges when analyzing data from a SMART in the presence of missing data. This paper presents the first comprehensive discussion of missing data issues typical of SMART studies: we describe five specific challenges, and propose a flexible imputation strategy to facilitate valid statistical estimation and inference using incomplete data from a SMART. To illustrate these contributions, we consider data from the Clinical Antipsychotic Trial of Intervention and Effectiveness (CATIE), one of the most well-known SMARTs to date. PMID:24919867

  14. Human toxocariasis: current advances in diagnostics, treatment, and interventions.

    PubMed

    Moreira, Gustavo Marçal Schmidt Garcia; Telmo, Paula de Lima; Mendonça, Marcelo; Moreira, Angela Nunes; McBride, Alan John Alexander; Scaini, Carlos James; Conceição, Fabricio Rochedo

    2014-09-01

    Toxocariasis is a neglected zoonosis caused by the nematodes Toxocara canis and Toxocara cati. This disease is widespread in many countries, reaching high prevalence independently of the economic conditions. However, the true number of cases of toxocariasis is likely to be underestimated owing to the lack of adequate surveillance programs. Although some diagnostic tests are available, their sensitivity and specificity need to be improved. In addition, treatment options for toxocariasis are limited and are non-specific. Toxocariasis is listed as one of the five most important neglected diseases by the CDC. This review presents recent advances related to the control of toxocariasis, including new immunodiagnostics, therapies, and drug formulations, as well as novel interventions using DNA vaccines, immunomodulators, and probiotics.

  15. Hepatic toxocariasis: a rare cause of right upper abdominal pain in the emergency department.

    PubMed

    Coşkun, Figen; Akıncı, Emine

    2013-01-01

    Toxocara canis and Toxocara cati are common helminths that reside in the intestinal tract of cats and dogs. Toxocariasis and, commonly, T. canis, is a disease commonly seen in children, which is characterised by hypereosinophilia, hepatomegaly, fever, transient pulmonary infiltration, and hypergammaglobulinaemia. Humans, who are not the actual host for these parasitic worms, are infected following oral intake of the infective eggs. Radiological differentiation of hepatic toxocariasis can be difficult, as liver lesions, which present as multiple hypoechoic lesions with regular borders, can look like a tumour, an infarction or an infection. We report on a case that presented to our emergency department (ED) with abdominal pain. During the initial review, the pathology in the liver was thought to be an infarction or an infection; however, the patient was diagnosed with hepatic toxocariasis following further evaluation.

  16. Neglected parasitic infections in the United States: toxocariasis.

    PubMed

    Woodhall, Dana M; Eberhard, Mark L; Parise, Monica E

    2014-05-01

    Toxocariasis is a preventable parasitic disease that is caused by the dog and cat roundworms Toxocara cani and T. cati, respectively. Humans become infected when they accidently ingest infectious Toxocara eggs commonly found in contaminated soil; children are most often affected. Clinical manifestations of Toxocara infection in humans include ocular toxocariasis and visceral toxocariasis. Although infection with Toxocara can cause devastating disease, the burden of toxocariasis in the United States population remains unknown. In addition, risk factors for acquiring infection need to be better defined, and research needs to be conducted to better understand the pathophysiology and clinical course of toxocariasis. Development of diagnostic tests would enable clinicians to detect active infection, and determination of optimal drug regiments would ensure patients were appropriately treated. Addressing these public health gaps is necessary to understand and address the impact of toxocariasis in the United States.

  17. [Cardiovascular manifestations of human toxocariasis].

    PubMed

    Bolívar-Mejía, Adrián; Rodríguez-Morales, Alfonso J; Paniz-Mondolfi, Alberto E; Delgado, Olinda

    2013-01-01

    Toxocariasis is a parasitic infection produced by helminths that cannot reach their adult stage in humans. For their etiological species (Toxocara canis and Toxocara cati), man is a paratenic host. Infection by such helminths can produce a variety of clinical manifestations, such as: visceral larvae migrans syndrome, ocular larvae migrans syndrome and covert toxocariasis. In the visceral larvae migrans syndrome, the organs that are mainly involved include liver, lungs, skin, nervous system, muscles, kidneys and the heart. Regarding the latter, the importance of cardiovascular manifestations in toxocariasis, as well as its clinical relevance, has increasingly begun to be recognized. The current article is based on a systematic information search, focused mainly on the clinical and pathological aspects of cardiovascular manifestations in toxocariasis, including its pathophysiology, laboratory findings, diagnosis and therapeutical options, with the objective of highlighting its importance as a zoonosis and its relevance to the fields of cardiovascular medicine in adults and children.

  18. Soil Contamination with Toxocara Spp. Eggs in Public Parks of Mashhad and Khaf, North East of Iran.

    PubMed

    Berenji, Fariba; Movahedi Rudy, Abdul Ghayoum; Fata, Abdolmajid; Tavassoli, Mousa; Mousavi Bazaz, Mojtaba; Salehi Sangani, Ghodratolah

    2015-01-01

    Toxocariasis is an important disease caused by the larvae of parasitic worms such as Toxocara canis and T. cati. Public parks can be the source of toxocariasis for small children. This survey was conducted to determine the prevalence of Toxocara spp. ova in parks of Mashhad and Khaf northeastern Iran. In this descriptive cross-sectional study, performed in November 2011 to June 2012, overall, 340 soil samples were collected from 39 parks of Mashhad and 29 parks in Khaf city. Flotation method and direct smear were used, and the samples were evaluated using a light microscope. The results were analyzed using SPSS version 19 and Chi-square test. In the evaluation of 195 and 145 soil samples, 18 (9.2%) and 16 cases (11.3%) of contamination with Toxocara spp. eggs were detected, respectively. Although the prevalence of Toxocara eggs in soil samples was low, parks can be a source of Toxocara infection of children in these areas.

  19. Perovskite-type titanate zirconate as photocatalyst for textile wastewater treatment.

    PubMed

    Ferrari-Lima, A M; Ueda, A C; Bergamo, E A; Marques, R G; Ferri, E A V; Pinto, C S; Pereira, C A A; Yassue-Cordeiro, P H; Souza, R P

    2016-09-10

    Calcium titanate zirconate, Ca(Ti(1-x)Zrx)O3 (CZT), powders have been synthesised by the polymeric precursor method. The structural analysis of the CZT powders was monitored by X-ray diffraction (XRD), photoacoustic spectroscopy (PAS) and textural analysis. The photocatalytic properties were evaluated by methylene blue (MB) decomposition and real textile wastewater (RTW) combined treatment (coagulation/flocculation/photocatalysis). Chemical oxygen demand (COD) of RTW was successfully reduced from 6195 mg L(-1) (untreated) to 662 mg L(-1) after coagulation/flocculation with a tannin-based coagulant (Tanfloc®) and finally to 471 mg L(-1) after combined treatment (coagulation/flocculation/photocatalysis) applying ultraviolet radiation and CaTiO3 as photocatalyst.

  20. A cross-sectional study of Tritrichomonas foetus infection in feral and shelter cats in Prince Edward Island, Canada.

    PubMed

    Raab, Oriana; Greenwood, Spencer; Vanderstichel, Raphael; Gelens, Hans

    2016-03-01

    A cross-sectional study examined the occurrence of Tritrichomonas foetus, and other intestinal parasites, in feral and shelter cats in Prince Edward Island (PEI). Fecal samples were collected from 100 feral cats, 100 cats from the PEI Humane Society, and 5 cats from a private residence. The occurrence of T. foetus, based on fecal culture, was 0% in feral and shelter cats. A single positive sample was obtained from an owned Abyssinian cat that was imported to PEI. Intestinal parasites were identified via fecal flotation in 76% of feral cats and 39% of cats from the humane society. Feral cats had a higher incidence of Toxocara cati than cats from the humane society (P < 0.001), conversely, shelter cats had a higher incidence of Cystoisospora spp. (P < 0.001). These results suggest that while T. foetus is not of importance in feral and shelter cats in PEI, imported cats could serve as reservoirs.