Contribution of the "Institut Scientifique Chérifien" to the development of geoscientific research in Northwest Africa since its creation in 1914

NASA Astrophysics Data System (ADS)

Medina, F.

2013-08-01

The contribution of the "Institut Scientifique Chérifien", the oldest scientific research centre in Morocco, is reviewed since its creation almost a century ago. Planned in 1914 by the French protectorate of Morocco, this institute has played, since its effective creation in 1920, an important role in the development of several geosciences in North Africa, such as meteorology and climatology, geophysics (gravimetry, magnetism and especially seismology), geomorphology, geology and oceanography. After the independence of Morocco in 1955, several activities, such as meteorology, were transferred elsewhere, but others, such as seismology and magnetism, remained important elements of the centre until recent years. In addition to the research activities, its observatories and libraries that were built during the early years are unique in Northwest Africa.

Science Scholars Program

DTIC Science & Technology

1994-06-30

Recherche Scientifique, France The Absolute Galois Group from a Geometric Viewpoint LESLIE C SHAW Fellow (Anthropology and Archaeology ) University of...Massachusetts it Boston The Emergence of Inequality in the Maya Lowlands PATRICIA L. SIPE Fellow (Mathematics) Smith College DES and Risk

Engaging the Public to Identify Opportunities to Improve Critical Care: A Qualitative Analysis of an Open Community Forum

PubMed Central

Potestio, Melissa L.; Boyd, Jamie M.; Bagshaw, Sean M.; Heyland, Daren; Oxland, Peter; Doig, Christopher J.; Zygun, Dave; Stelfox, Henry T.

2015-01-01

Objective To engage the public to understand how to improve the care of critically ill patients. Design A qualitative content analysis of an open community forum (Café Scientifique). Setting Public venue in Calgary, Alberta, Canada. Participants Members of the general public including patients, families of patients, health care providers, and members of the community at large. Methods A panel of researchers, decision-makers, and a family member led a Café Scientifique, an informal dialogue between the populace and experts, over three-hours to engage the public to understand how to improve the care of critically ill patients. Conventional qualitative content analysis was used to analyze the data. The inductive analysis occurred in three phases: coding, categorizing, and developing themes. Results Thirty-eight members of the public (former ICU patients, family members of patients, providers, community members) attended. Participants focused the discussion and provided concrete suggestions for improvement around communication (family as surrogate voice, timing of conversations, decision tools) and provider well-being and engagement, as opposed to medical interventions in critical care. Conclusions Café participants believe patient and family centered care is important to ensure high-quality care in the ICU. A Café Scientifique is a valuable forum to engage the public to contribute to priority setting areas for research in critical care, as well as a platform to share lived experience. Research stakeholders including health care organizations, governments, and funding organizations should provide more opportunities for the public to engage in meaningful conversations about how to best improve healthcare. PMID:26580406

Engaging the Public to Identify Opportunities to Improve Critical Care: A Qualitative Analysis of an Open Community Forum.

PubMed

Potestio, Melissa L; Boyd, Jamie M; Bagshaw, Sean M; Heyland, Daren; Oxland, Peter; Doig, Christopher J; Zygun, Dave; Stelfox, Henry T

2015-01-01

To engage the public to understand how to improve the care of critically ill patients. A qualitative content analysis of an open community forum (Café Scientifique). Public venue in Calgary, Alberta, Canada. Members of the general public including patients, families of patients, health care providers, and members of the community at large. A panel of researchers, decision-makers, and a family member led a Café Scientifique, an informal dialogue between the populace and experts, over three-hours to engage the public to understand how to improve the care of critically ill patients. Conventional qualitative content analysis was used to analyze the data. The inductive analysis occurred in three phases: coding, categorizing, and developing themes. Thirty-eight members of the public (former ICU patients, family members of patients, providers, community members) attended. Participants focused the discussion and provided concrete suggestions for improvement around communication (family as surrogate voice, timing of conversations, decision tools) and provider well-being and engagement, as opposed to medical interventions in critical care. Café participants believe patient and family centered care is important to ensure high-quality care in the ICU. A Café Scientifique is a valuable forum to engage the public to contribute to priority setting areas for research in critical care, as well as a platform to share lived experience. Research stakeholders including health care organizations, governments, and funding organizations should provide more opportunities for the public to engage in meaningful conversations about how to best improve healthcare.

Press conference

ScienceCinema

None

2017-12-09

Exposés de plusieurs intervenants de la direction et du conseil, comme le Prof.Ramsey, président du conseil sur l'adhésion récente de la Finlande et le "boom" scientifique des pays de l'est.

Colloquy to Paul Musset

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2007-12-13

En honneur de Paul Musset il a été décidé de faire plutôt un colloque scientifique à la place d'une cérémonie. Plusieurs personnes temoignent de leurs estime et amitié pour ce physicien et ses activités

The Computerization of the National Library in Paris.

ERIC Educational Resources Information Center

Lerin, Christian; Bernard, Annick

1986-01-01

Describes the organization and automation plan of the Bibliotheque Nationale (Paris, France) that was begun in 1981. Highlights include the method of moving toward computerization; technical choices; the choosing procedure (pre-qualification, bench-mark test); short term and pilot operations; and preparation for the implementation of the…

The Quebec National Library on the Web.

ERIC Educational Resources Information Center

Kieran, Shirley; Sauve, Diane

1997-01-01

Provides an overview of the Quebec National Library (Bibliotheque Nationale du Quebec, or BNQ) Web site. Highlights include issues related to content, design, and technology; IRIS, the BNQ online public access catalog; development of the multimedia catalog; software; digitization of documents; links to bibliographic records; and future…

Fleischmann seminar (fusion)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2007-10-25

"pictures, television out, no flash and camera, there will be a press section later on in the council room if Prof. Fleischmann will accept"..le DG C.Rubbia insiste pour cette discussion scientifique de ne pas filmer, autrement de bien quitter la salle, ce qui provoque un petit remue-ménage...

21 CFR Appendix B to Subpart A of... - List of Authorities

Code of Federal Regulations, 2011 CFR

2011-04-01

... Control Farmacéutico. For medicinal products for veterinary use: Ministerio de Agricultura, Pesca y...: Agence du Médicament. For veterinary medicinal products: Agence Nationale du Médicament Vétérinaire..., Dipartimento Farmaci e Farmacovigilanza. For medicinal products for veterinary use: Ministero della Sanità...

Border Jumping: Strategic and Operational Considerations in Planning Cross-Border Raids Against Insurgent Sanctuaries

DTIC Science & Technology

2013-06-01

POLITICAL COSTS .......25 D. THE OVERALL TIMING OF NICARAGUAN CROSS-BORDER OFFENSIVES...27 E. THE TERMINATION OF NICARAGUAN CROSS-BORDER RAIDS...Exploit, and Analyze FARC Revolutionary Armed Forces of Colombia FDN Nicaraguan Democratic Force FLN Front de Libération Nationale FSLN Sandinista

La politique scientifique comme mise en espace-temps de la recherche= Science Policy as Placed in the Space-Time Relationship of Research.

ERIC Educational Resources Information Center

Turmel, Andre

1986-01-01

The language used by scientists to discuss their work and the social logic underlying scientific research is examined, and viewed from the perspective and as an extension of the space-time continuum that scientists study. (Author/MSE)

Fleischmann seminar (fusion)

ScienceCinema

None

2017-12-09

"pictures, television out, no flash and camera, there will be a press section later on in the council room if Prof. Fleischmann will accept"..le DG C.Rubbia insiste pour cette discussion scientifique de ne pas filmer, autrement de bien quitter la salle, ce qui provoque un petit remue-ménage...

Documenting and Researching Endangered Languages: The Pangloss Collection

ERIC Educational Resources Information Center

Michailovsky, Boyd; Mazaudon, Martine; Michaud, Alexis; Guillaume, Séverine; François, Alexandre; Adamou, Evangelia

2014-01-01

The Pangloss Collection is a language archive developed since 1994 at the Langues et Civilisations à Tradition Orale (LACITO) research group of the French Centre National de la Recherche Scientifique (CNRS). It contributes to the documentation and study of the world's languages by providing free access to documents of connected, spontaneous…

IFLA General Conference, 1985. Division of Bibliographic Control. Sections on Bibliography, Cataloging, and Classification. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on cataloging and classification which were presented at the 1985 International Federation of Library Associations (IFLA) conference include: (1) "Online Cataloging at the Bibliotheque Nationale (Francoise Finelli and Serge Salomon, France); (2) "Development of National Press Repertoire in the Condition of Multinational State: Its…

International Meeting on Business Start-up (Lille, France, November 26-28, 1992).

ERIC Educational Resources Information Center

Melis, Africa, Ed.; Peigne, Florence, Ed.

1992-01-01

An international meeting explored work on business start-up undertaken jointly by CEDEFOP (European Centre for the Development of Vocational Training) and France's Agence Nationale pour la creation d'entreprise. One opening presentation (Melis) addressed the basic idea underlying the research: to identify and highlight the role of training and…

Tyche 3.0 Simulation Engine Project Review

DTIC Science & Technology

2014-10-09

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC-2014-C220 Page 2 RECORD OF...During the technical evaluation, it was found that the representation of internal data as class objects and collections had performance drawbacks and

Colloquy to Paul Musset

ScienceCinema

None

2017-12-09

En honneur de Paul Musset il a été décidé de faire plutôt un colloque scientifique à la place d'une cérémonie. Plusieurs personnes temoignent de leurs estime et amitié pour ce physicien et ses activités

The new role of scientists

ScienceCinema

None

2017-12-09

Le D.G. Jentschke fait l'introduction et présente le Prof.Kowarsky, spécialiste en microbiologie, physique nucléaire et une des fondateurs du Cern. Il parle entre autre de l'énergie nucléaire (pacifique)et de remise en questions des valeurs scientifiques et techniques

Le recours aux modeles dans l'enseignement de la biologie au secondaire : Conceptions d'enseignantes et d'enseignants et modes d'utilisation

NASA Astrophysics Data System (ADS)

Varlet, Madeleine

Le recours aux modeles et a la modelisation est mentionne dans la documentation scientifique comme un moyen de favoriser la mise en oeuvre de pratiques d'enseignement-apprentissage constructivistes pour pallier les difficultes d'apprentissage en sciences. L'etude prealable du rapport des enseignantes et des enseignants aux modeles et a la modelisation est alors pertinente pour comprendre leurs pratiques d'enseignement et identifier des elements dont la prise en compte dans les formations initiale et disciplinaire peut contribuer au developpement d'un enseignement constructiviste des sciences. Plusieurs recherches ont porte sur ces conceptions sans faire de distinction selon les matieres enseignees, telles la physique, la chimie ou la biologie, alors que les modeles ne sont pas forcement utilises ou compris de la meme maniere dans ces differentes disciplines. Notre recherche s'est interessee aux conceptions d'enseignantes et d'enseignants de biologie au secondaire au sujet des modeles scientifiques, de quelques formes de representations de ces modeles ainsi que de leurs modes d'utilisation en classe. Les resultats, que nous avons obtenus au moyen d'une serie d'entrevues semi-dirigees, indiquent que globalement leurs conceptions au sujet des modeles sont compatibles avec celle scientifiquement admise, mais varient quant aux formes de representations des modeles. L'examen de ces conceptions temoigne d'une connaissance limitee des modeles et variable selon la matiere enseignee. Le niveau d'etudes, la formation prealable, l'experience en enseignement et un possible cloisonnement des matieres pourraient expliquer les differentes conceptions identifiees. En outre, des difficultes temporelles, conceptuelles et techniques peuvent freiner leurs tentatives de modelisation avec les eleves. Toutefois, nos resultats accreditent l'hypothese que les conceptions des enseignantes et des enseignants eux-memes au sujet des modeles, de leurs formes de representation et de leur approche constructiviste en enseignement representent les plus grands obstacles a la construction des modeles en classe. Mots-cles : Modeles et modelisation, biologie, conceptions, modes d'utilisation, constructivisme, enseignement, secondaire.

Segmentation of the Striatum Using Data Fusion

DTIC Science & Technology

2001-10-25

palsy. Ann Neurol 1999; 45:1 65-74. [3] Barra V. in Fusion d’images 3D du cerveau : études de modèles et applications. Ph.D. Thesis, Université...in Segmentation des structure internes du cerveau . Ph. D. Thesis, Ecole Nationale Supérieure des Télécommunications, Paris (France), 1998. [15

Passion Research: A Joint Venture To Interest High School Students in Chemistry.

ERIC Educational Resources Information Center

Carriere, Francois J.; Abouaf, Madeleine

1997-01-01

Describes a joint venture between the Centre National de la Recherche Scientifique (CNRS) and the Department of Education in France that was created to allow students to do practical scientific work with the help of a CNRS researcher. Presents two practical projects done by students on organic polymers and on color. Concludes that this increases…

Diagnostik von Kontingenzerfahrungen in der fruehen Kindheit. Forschungsbericht Rapport Scientifique. Nr. 68. (Methods of Social Contingency Analysis. FB Nr. 68).

ERIC Educational Resources Information Center

Perrez, Meinrad

Written in German, this article demonstrates the influence of different types of contingency information on the development of infant's locus of control and causal attribution, and discusses empirical models for calculating contingency parameters of the microsocial environment of infants, toddlers, and preschool children. Models discussed include:…

Le Francais des Professions Scientifiques et Techniques (French for the Scientific and Technical Professions).

ERIC Educational Resources Information Center

Muller, Brigitte

Two sequential courses in scientific and technical French developed as a supplement to third- and fourth-year college French, in response to expressed student and industry demand, had as their objectives to develop a general familiarity with products of the large French industrial companies and their United States affiliates and to develop means…

L'Harmonisation des langues Maliennes: Entre l'intregration nationale et regionale (The Harmonization of the Malian Languages: Between National and Regional Integration).

ERIC Educational Resources Information Center

Ouane, Adama

1991-01-01

Assesses efforts to standardize the Malian languages, including the standardization of orthography and the creation of terminology in the Mandingo-Peul Project. Points to conflicts between technical and political considerations, and between local tendencies and balances among languages and the need to respect the ecolinguistics of the country.…

Self-Cleaning Coatings

DTIC Science & Technology

2014-06-01

Canada), telle que representee par le ministre de la Defense nationale, 2014 i Abstract Under certain conditions, military coatings...μm Particle C: a compound of fluorinated polymer and polypropylene , mean particle size 9 μm Due to the fact that all three types of particles have...functional particles, which are either pure fluorinated polymer or compound of fluorinated polymer and polypropylene , possessing certain degrees of

Cultural Dimensions of Digital Library Development, Part II: The Cultures of Innovation in Five European National Libraries (Narratives of Development)

ERIC Educational Resources Information Center

Dalbello, Marija

2009-01-01

This article presents the narrative accounts of the beginnings of digital library programs in five European national libraries: Biblioteca nacional de Portugal, Bibliotheque nationale de France, Die Deutsche Bibliothek, the National Library of Scotland, and the British Library. Based on interviews with policy makers and developers of digital…

Local network interconnection through a satellite point-to-multipoint link. Ph.D. Thesis - Ecole Nationale Superieure des Telecommunications, 6 Jul. 1985

NASA Technical Reports Server (NTRS)

Duarte, O. Muniz Bandeira

1986-01-01

Four architectures to implement a point to multipoint satellite link protocol for communication services offered by the Telecom 1 satellite network are presented. A safe communication service with error correction and flow control facilities is described. It is shown that a time transparent communication system combines simplicity and cost advantages.

Zone Nationale D'Etude de L'Environnment: Un Guide (National Environmental Study Area: A Guide).

ERIC Educational Resources Information Center

National Park Service (Dept. of Interior), Washington, DC.

This booklet, the French version of SE 014 817, is a guide for teachers and resource managers who are interested in establishing National Environmental Study Areas (NESA) or interested in receiving NESA recognition for their on-going environmental study area programs. It outlines the characteristics and procedures of the program; the nature,…

Etude RICH Nursing. Plus de connaissances et de preuves scientifiques

PubMed Central

SCHUBERT, MARIA

2009-01-01

L’importance et la validité des résultats de l’étude RICH-Nursing* ont été récemment mises en cause par certains milieux, ce qui a provoqué certaines incertitudes chez les infirmières. Les auteurs reviennent sur l’impact actuel de cette étude et évoquent les perspectives d’avenir. PMID:25221376

Low Temperature Quartz Crystal Oscillator Fast Warm-Up Saw Oscillator.

DTIC Science & Technology

1981-07-01

TASK_Q Centre National de la Recherche ScientifiqueARA&WKLI k Laboratoire de Physique et Metrologie des!2 Oscillateurs - 50 Bsnon-F 2 3 32 av. o l...propri6t6s non lin6aires des ondes Alastiques de sur- face : applications aux oscillateurs et aux capteurs A quartz", Thse Besanqon, 1979. (6) D. Hauden, G

Partager : des technologies de pointe au service de la société

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2011-02-14

Médecine, climatologie, métrologie et informatique, les techniques utilisées par le LHC trouvent déjà des répercussions dans d’autres domaines scientifiques. Utilisant des techniques inédites, la physique des particules en fait bénéficier la société toute entière.

Proceedings of the Annual Conference of the International Group for the Psychology of Mathematics Education (13th, Paris, France, July 9-13, 1989), Volume 1.

ERIC Educational Resources Information Center

International Group for the Psychology of Mathematics Education.

This proceedings of the annual conference of the International Group for the Psychology of Mathematics Education (PME) includes the following papers: "Transformations Accelerees de l'Education Scientifique Pendant la Revolution Francaise" (Jean Dhombres); "Building on the Knowledge of Students and Teachers" (Thomas P. Carpenter & Elizabeth…

Northern Scientific Training Program: Annual Report, 1999-2000 = Programme de formation scientifique dans le Nord: Rapport annuel, 1999-2000.

ERIC Educational Resources Information Center

Department of Indian Affairs and Northern Development, Ottawa (Ontario).

The Northern Scientific Training Program (NSTP) is managed by the Department of Indian Affairs and Northern Development as part of its mandate to foster science and technology in the Canadian North. NSTP supports Canadian universities in providing training that gives advanced and graduate students the opportunity to gain professional experience in…

New Caledonia: The Fragile Peace

DTIC Science & Technology

1990-06-01

Jane Tiburzio, teacher in North Province Jean-Marie Tjibaou, president , Front de Liberation Nationale Kanake Socialiste (deceased) Sarah Walls , Sydney...status. New Caledonia’s extremely rich nickel and possibly other mineral resources and the sizable French population make the territory a key link in...remaining 23 were held hostage in a cave. Negotiations to free the hostages failed, and on May 5 French commandos assaulted the cave. Nineteen Kanaks

Combat Resource Allocation Planning in Naval Engagements

DTIC Science & Technology

2007-08-01

presented and discussed in this report. The coordination problems are discussed in the companion report [2]. The developed Agent and Multi-agent-based...Technology Chef de file au Canada en matière de science et de technologie pour la défense et la sécurité nationale WWW.drdc-rddc.gc.ca Defence R&D Canada R & D pour la défense Canada

Security Classification Using Automated Learning (SCALE): Optimizing Statistical Natural Language Processing Techniques to Assign Security Labels to Unstructured Text

DTIC Science & Technology

2010-12-01

recommend [13]. 2.2 Commercial content scanning technology In [16], a companion piece to this paper, Magar completed a thorough review of commercially...defense Canada Chef de file au Canada en matiere de science et de technologie pour la defense et la securite nationale DEFENCE ~~EFENSE (_.,./ www.drdc-rddc.gc.ca

Acousto-Optic Spectrum Analyzer: Temporal Response and Detection of Pulsed Signals.

DTIC Science & Technology

1986-12-01

ACOUSTO - OPTIC SPECTRUM ANALYZER: TEMPORAL RESPONSE AND I/i DETECTION OF PULSED SIGUALS(U) DEFENCE RESEARCH ESTABLISHMENT OTTANA (ONTARIO) J...8217:. -.....:.-...............--.. - ---:-..--.-..,. ,: i’,.. IJT~c FILE C P National Defe’ se + Deence nationale 0 0 ACOUSTO - OPTIC SPECTRUM ANALYZER: TEMPORAL RESPONSE AND DETECTION 0 OF PULSED...Ottawa |S, .±~ |-----------------------..,---.-- -- - - - rNatiorna! Defen~se Deterice r dornale ACOUSTO - OPTIC SPECTRUM ANALYZER: TEMPORAL RESPONSE

The INSU and DMN network of ST radars

NASA Technical Reports Server (NTRS)

Petitdidier, M.; Klaus, V.; Baudin, F.; Crochet, M.; Penazzi, G.; Quinty, P.

1986-01-01

Due to their capabilities of measuring wind profiles with good time and height resolution, Stratosphere-Troposphere (ST) are well adapted to carry out atmospheric research. In France, a Very High Frequency (VHF) and an Ultrahigh Frequency (UHF) ST radar are working for research purposes. The INSU (Institut National des Sciences de l'Univers) and the DMN (Direction de la Meteorologie Nationale) networks are discussed.

Caracterisation Physique des Sols Camp Militaire de Petawawa (Physical Characterization of the Soil in Military Camp of Petawawa).

DTIC Science & Technology

1979-10-01

AD-AO95 392 DEFENCE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO) FI6 8/13 CARACTERISATION PHY SI QUE DES SOLS CAMP MILITAIRE DE PETAWAWA (P--ETC(U) OCT 79...defense nationale 2b, GROUP Ottawa, Ontario -KIA-04----- , I D )kI1,vlt Nr Ti fti CARACTERISATION PHYSIQUE DES SOLS, BASE DES FORCES CANADIENNES PETAWAAA I

French Plans for Fifth Generation Computer Systems.

DTIC Science & Technology

1984-12-07

centrally man- French industry In electronics, compu- aged project in France that covers all ters, software, and services and to make the facets of the...Centre National of Japan’s Fifth Generation Project , the de Recherche Scientifique (CNRS) Cooper- French scientific and industrial com- ative Research...systems, man-computer The National Projects interaction, novel computer structures, The French Ministry of Research and knowledge-based computer systems

La supraconductivité a 100 ans !

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebrun, Philippe

2011-04-14

Il y a 100 ans, le 8 avril 1911, une découverte majeure était réalisée : celle de la supraconductivité. La supraconductivité est la caractéristique qu’ont certains métaux et alliages de perdre toute résistance électrique en dessous d’une température donnée. Cette renversante découverte, réalisée de manière presque fortuite par Kammerlingh Onnes de l’Université de Leyde (Pays-Bas) et son étudiant Gilles Holst, a ouvert un nouveau champ de recherche en physique et de fabuleuses perspectives d’applications technologiques. Du point de vue scientifique, la supraconductivité est en effet l’une des rares manifestations de la physique quantique à l’échelle macroscopique.  Du point de vuemore » des retombées techniques, elle est porteuse d’applications majeures dans le domaine de la santé, des communications et de l’énergie. 100 ans après, les physiciens n’ont toujours pas fini d’explorer ce phénomène et ses applications. Le CERN abrite des applications de la supraconductivité à des échelles inédites. L’accélérateur de particules LHC, avec ses milliers d’aimants supraconducteurs répartis sur 27 kilomètres de circonférence, est en effet la plus grande application mondiale de la supraconductivité. Il ne pourrait exister sans elle. Le CERN fête donc la découverte de la supraconductivité avec une conférence exceptionnelle donnée par Philippe Lebrun. Au cours de cette conférence, l’expérience historique de Kammerlingh Onnes sera reproduite. Philippe Lebrun racontera l’histoire de cette étonnante découverte, en la replaçant dans le contexte scientifique de l’époque. Il racontera les développements scientifiques et les applications du premier siècle de la supraconductivité. Conférence en français Merci de bien vouloir vous inscrire au : +41 22 767 76 76 ou cern.reception@cern.ch« less

Cumulative Viral Load and Virologic Decay Patterns after Antiretroviral Therapy in HIV-Infected Subjects Influence CD4 Recovery and AIDS

DTIC Science & Technology

2011-05-20

study). The Antiproteases Cohorte Agence Nationale de Recherches sur le SIDA EP 11 study. J Infect Dis 186: 710–714. 8. Hermankova M, Ray SC, Ruff C... Sida (ANRS) CO3 Aquitaine Cohort. Clin Infect Dis 49: 1109–1116. 59. Choi AI, Shlipak MG, Hunt PW, Martin JN, Deeks SG (2009) HIV-infected persons

Mobile Ad Hoc Networks: An Evaluation of Smartphone Technologies

DTIC Science & Technology

2011-10-01

National Defence, 2011 c© Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 Abstract A...déploiement de protocoles au cours d’opérations des FC ; 4. le développement d’une implémentation de validation de principe sur un téléphone

The influence of international and domestic events in the evolution of forest inventory and reporting consistency in the United States

Treesearch

W. Brad Smith

2009-01-01

This article takes a brief chronological look at resource inventory and reporting and links to international influences. It explores events as drivers of more consistent data within the United States and highlights key dates and events in the evolution of inventory policy and practice. From King George to L?Ecole nationale forestiere to the Food and Agriculture...

Energetic Materials Hazard Initiation: DoD Assessment Team Final Report

DTIC Science & Technology

1987-05-05

which the Department of De - fense is now emphasizing (JROC, 1986). Although this aspect of hazards reduction primarily involves fielded systems and the...source of deficiency in the impact testing. Some efforts are reported in which phototransistors, IR sensors and/or pressure sensors are used to detect...Montgomery (1959), and Moore (1973). Recent research on the electrostatic discharge sensitivity of solid propellant samples was begun at Societe Nationale des

Opportunities for Tomorrow: National Learning Needs Assessment Summary Report = Des Possibilities pour L'Avenir: Rapport Sommaire sur L'Evaluation Nationale des Besoins en Apprentisage.

ERIC Educational Resources Information Center

Communications, Energy & Paperworkers Union of Canada, Ottawa (Ontario).

The Communications, Energy, and Paperworkers Union of Canada assessed literacy learning needs. In focus group discussions, members were asked their perception of such needs in the face of changes in the workplace and society; local union officers (LUOs) were asked how they saw the role of unions in supporting members' literacy learning; employers…

Hybrid Warfare: Implications for CAF Force Development

DTIC Science & Technology

2014-08-01

of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014...the spirit of international law. Finally, these basic definitions, however flawed, serve an additional purpose. Any investigation into the...Beyond official internal lessons learned reports from various militaries much useful information is contained in, for example, the many and topically

Survey of Commercial Technologies for Face Recognition in Video

DTIC Science & Technology

2014-09-01

by Defence Research and Development Canada’s Centre for Security Science, in partnership with Public Safety Canada. Led by Canada Border Services...Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 Science and Engineering Directorate Border...Objectives CO1 – Engage in rapid assessment, transition and deployment of innovative technologies for public safety and security practitioners to achieve

Architecture and Assessment: Privacy Preserving Biometrically Secured Electronic Documents

DTIC Science & Technology

2015-01-01

very large public and private fingerprint databases comprehensive risk analysis and system security contribution to developing international ...Safety and Security Program which is led by Defence Research and Development Canada’s Centre for Security Science, in partnership with Public Safety...201 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 201 Science and Engineering

Cultural Dimensions of Digital Library Development, Part I: Theory and Methodological Framework for a Comparative Study of the Cultures of Innovation in Five European National Libraries

ERIC Educational Resources Information Center

Dalbello, Marija

2008-01-01

This study examines the influence of culture on digital libraries of the first wave. The local cultures of innovation of five European national libraries (Biblioteca nacional de Portugal, Bibliotheque nationale de France, Die Deutsche Bibliothek, the National Library of Scotland, and the British Library) are reconstructed in case histories from…

Net Assessment in the 1930s

DTIC Science & Technology

1990-10-01

SHA Carton 7N2515, and Henri Navarre , Le Service de Renseignments. 1871-1944 (Paris, 1978), p. 79. 86. Gauchd, Le Deuxieme Bureau, p. 133, and SHA...circumstances tended to dilute the intelligence analysis of these operations. Although individual officers like Charles de Gaulle, Percy Hobart, and...Comit6 Permanent de Defense Nationale without revealing too much of their deliberations to the Germans and Italians and their domestic political critics

Urban Population Control in a Counterinsurgency

DTIC Science & Technology

2005-01-01

national liberation war by nationalists and Islamists. The enemy was France, colonialism and Christianity. In 1940-1945, French and Arab nationalist...During 1956 and 1957, the National Liberation Army (Armée de Libération Nationale -- ALN), the FLN’s military arm, successfully applied guerrilla hit...Individual homes in this area normally have a courtyard where trees and flowers grow, chickens scratch and cars and bicycles are parked . One enters the

(Low-level radioactive waste management techniques)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Hoesen, S.D.; Kennerly, J.M.; Williams, L.C.

1988-08-08

The US team consisting of representatives of Oak Ridge National Laboratory (ORNL), Savannah River plant (SRP), Idaho National Engineering Laboratory (INEL), and the Department of Energy, Oak Ridge Operations participated in a training program on French low-level radioactive waste (LLW) management techniques. Training in the rigorous waste characterization, acceptance and certification procedures required in France was provided at Agence Nationale pour les Gestion des Dechets Radioactif (ANDRA) offices in Paris.

Building a More Resilient Haitian State

DTIC Science & Technology

2010-01-01

See World Health Organization. Wolff, Laurence, Education in Haiti: The Way Forward, Washington, D.C.: Programa de Promoción de la Reforma Educativa de ...Provide sufficient donor funding to implement a reformulated strategy for administrative reform based on Programme-Cadre de Réforme de l’Etat...Ministry of Educa- tion and Training (Ministère de l’Education Nationale et de la Formation Professionnelle, or MENFP) should subsidize private- school

Stress Corrosion of Ceramic Materials.

DTIC Science & Technology

1983-10-01

ACCESSION NO. 3 RECIPIENT’S CATALOG NUMBER £ TITLE (and Subilie) S. TYPE OF REPORT & PERIOD COVERED Annual Stress Corrosion of Ceramic Materials 1 Nov...ener- behavior. This type of interaction is quite different from the chemi- gies for deuterium and protium which, in barn, results in different cal...Scientifique Continentale du Verre , Charleroi, Belgium, 1962. Dunning, J.M., Effects of Aqueous Chemical Environments on Crack Propagation in Quartz, this volume

Indexation Rules for Metallurgy in PASCAL. Original Title: Regles d'Indexation de la Metallurgie'--Technical Note Issued by Informascience--January 1980. Translated by Marie Wallin.

ERIC Educational Resources Information Center

Royal Inst. of Tech., Stockholm (Sweden). Library.

The indexing rules presented are designed for use with a new French-German database on metallurgy being developed under an agreement by CNRS (Centre National de la Recherche Scientifique, Paris) and BAM (Bundesanstalt fur Materialprufung, Berlin). The new database, which will feature multilingual titles and index terms (French-German-English-) and…

European Scientific Notes. Volume 36, Number 4.

DTIC Science & Technology

1982-03-30

de of gray cast iron, Mampaey demonstrated that Recherches Scientifiques et Techniques de the minimum riser dimensions needed to obtain I’lndustrie...through the nonprofit He is now making a similar study of ’nodular Industrial association Fabrimetal (Fdlration des cast iron. entreprises de I’industrie...SCIENTIFIC NOTES April 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(&) II. CONTRACT OR GRANT NUMBER(e) 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10

Interpretation d'une Controverse Scientifique: Strategies Argumentatives d'Adolescentes et d'Adolescents Quebecois (Interpretation of a Scientific Controversy: Argument Strategies of Adolescents and Quebecois Adolescents).

ERIC Educational Resources Information Center

Bader, Barbara

2003-01-01

Sketches out the argumentative strategies used by three 17-year-old boys to interpret the disagreement presented to them. Shows that they were inclined to adduce current ideas about science--framed according to a realist, empiricist epistemology--but that there are grounds for thinking that high school students would be capable of actualizing…

Foreword

NASA Astrophysics Data System (ADS)

Tanzi, Tullio Joseph; Chandra, Madhu

2018-01-01

URSI (Union Radio-scientifique internationale) is a renowned worldwide body under the umbrella of the International Council for Science, formerly International Council of Scientific Unions (ICSU). This scientific society has a longstanding tradition of fostering and coordinating, on an international basis, scientific studies, research, applications, exchanges, and communication in the fields of radio science and, more generally, on all aspects of electromagnetism. One of the URSI's roles is to promote research using interdisciplinary and multidisciplinary resources.

CapDEM Exercise Gamma: Results and Discussion

DTIC Science & Technology

2011-06-01

DU MATERIEL Assurer la gestion et la prestation de services d’infrastructure fiables. L’utilisation d’infrastructures de ...Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC Ottawa TR 2011-044 i Abstract...définition, l’ingénierie et la gestion collaboratives des capacités (DIGCap). L’objectif principal de ce dernier volet de la Stratégie

Defence Output Measures: An Economics Perspective

DTIC Science & Technology

2011-11-01

Des budgets de la comptabilité des intrants, des extrants, de la gestion et des ressources ont été utilisés comme mesures relatives aux résultats...Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 Abstract …….. This Contract Report...présent rapport de contrat examine la mesure des extrants en matière de

U.S. (ARRADCOM) Test Results for NATO Round-Robin Test on High Explosives

DTIC Science & Technology

1981-05-01

Round-Robin Test Hersteller: (Manufacturer) Probenbezeichnung: (sample symbol ) Fa. Dynamit Nobel AG (W-Germany) Werk Leverkusen-Schlebusch S - 1...0,050 % 0,004 % Beim Zufügen von 0,002 n KMnO,-Lösung zu einem durch Kochen mit Wasser er-. haltenem Auszug keine Entfärbung in 1 h (no...Hersteller: (manufacturer) Fa. Soc. Nationale des Poudres et Explosifs (SNPE) Poudrerie de Sorgues, Frankreich Probenbezeichnung: (sample symbol

Modelling Metrics for Mine Counter Measure Operations

DTIC Science & Technology

2014-08-01

the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014...a random search derived by Koopman is widely used yet it assumes no angular dependence (Ref [10]). In a series of publications considering tactics...Node Placement in Sensor Localization by Optimization of Subspace Principal Angles, In Proceedings of IEEE International Conference on Acoustics

The 2007 Surge in Iraq: An Alternative View

DTIC Science & Technology

2014-11-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC-2014-R105 i Abstract...9 Figure 4 US, international (coalition partners), and ISF troop strength. . . . . . . . . . . . . . . . . 14 Figure 5 Sum of monthly SIGACT...Testing the Surge: Why Did Violence Decline in Iraq in 2007?” International Security, 37(1), (2012), pp. 7–40. 9 A SIGACT usually refers to

Recherche universitaire et priorites nationales: l'effet du financement public sur la recherche energie solaire au Canada (University Research and National Priorities: The Effect of Public Financing on Solar Energy Research in Canada).

ERIC Educational Resources Information Center

Dalpe, Robert; Gingras, Yves

1990-01-01

The role of two main sources of university research financing in solar energy is examined to assess whether they oriented research in the direction of government programs. The strongest relationship appears to be in journal publication patterns. This scientific community has acquired the capacity to tap varying sources. (Author/MSE)

European Science Notes Information Bulletin (ESNIB) Reports on Current European/Middle Eastern Science

DTIC Science & Technology

1988-11-01

campus of the brane electric fields; and double layer Symposia included were on ceramics, Consejo Superior de Investigaciones structure theory and...units of the Ecole Nationale Superieure des Mines de Paris (ENSMP) - is discussed. Studies at the Center for Applied Mathematics include work for...Workshop on Low-Temperature Devices for De - tection of Low Energy Neutrino and Dark Matter are discussed. The topics are: the motivating ex

Geoffrey Burbidge : L'art de la critique

NASA Astrophysics Data System (ADS)

Bonnet-Bidaud, J. M.

1997-06-01

Avec pres de cinquante ans de carriere derriere lui, Geoffrey Burbidge n'a rien perdu de son gout du débat et de la controverse. Mondialement reconnu pour ses travaux sur les quasars, il en agace aujourd'hui plus d'un en venant deranger le bel ordonnancement de la cosmologie. Il porte sur le monde scientifique un regard tres critique, condamnant notamment ces chercheurs qui acceptent trop volontiers d'emprunter les chemins tout traces.

Micromechanisms of Crack Growth in Ceramics and Glasses in Corrosive Environments.

DTIC Science & Technology

1980-05-01

Resistance Mecanique du Verre et les Moyens de l’Amelioree, Union Scientifique Continentale du Verre , Charleroix, Belgium, (1962). 8. B. A. Proctor, I...exhibit similar types of delayed failure curves. Failure occurs most rapidly at high loads. Below a critical value of the load known as the stress...fracture for the three types of materials differ greatly. Polymers and metals have plastic zones at their crack tips, so that stress corrosion

The International Development Research Centre: A Guide for the Canadian University Research Community = Le Centre de recherches pour le developpement international: guide a l'intention des scientifiques des universites Canadiennes.

ERIC Educational Resources Information Center

Tillman, George; Wasilewski, Ania, Ed.

Written in both English and French this is a manual for the Canadian research community. It describes the International Development Research Centre (IDRC) and its operations. The main objective of the IDRC is to assist scientists in developing countries to identify and conduct research into long term practical solutions to development problems.…

Generalized Equations and Their Solutions. Part 2. Applications to Nonlinear Programming

DTIC Science & Technology

1980-03-01

7901066. Parts of the research for this paper were carried out at the Departement de Mathematiques elaD n Uversite Paris-IX Dauphine, with financial...support from the Centre National de la Recherche Scientifique, and at the Departamento de Matematicas y Ciencias de la Computaci6 n, Universidad Simon...Bolivar, Caracas, Venezuela, with support from the United Nations Educational, Scientific and Cultural Organization under Proyecto UNESCO VEN-77-002. The

Nonstandard Support Concepts in USAF Managed Security Assistance Program

DTIC Science & Technology

1977-06-01

example of this approach is found in the sale of Boeing 747 aircraft to the government of Iran for use as military transports (8Z). These aircraft were...would result in close-out action. RSAF would pay --or transportation packaging and handling for on-shelf assets to close out the account. (14) An...SABCA, and Fabrique Nationale d’ Armes de Guerre; the German companies of Hamburger Flugzeugbau, Weser Flugzeugbau, and Foche-Wolfe; and the Netherlands

Unifying Capability Integration Analysis - Initial Insights

DTIC Science & Technology

2011-09-01

mesure d’accomplir; Gestion des capacités – la mesure dans laquelle les FC seront en mesure de combler leurs besoins en matière de ...forces (DF) au sein du ministère de la Défense nationale (MDN). Au cours des quatre dernières années, des militaires et des analystes en matière de ...centralisée et descendante de développement des forces (DF) au sein du ministère de la

Statement of Operational Requirements (SOR): Guidance for Creating an SOR for Less Lethal Weapons

DTIC Science & Technology

2011-12-01

Canadian Police Research Centre (CPRC) and managed by Defence Research and Development Canada (DRDC) under the Centre for Security Science (CSS...telle que représentée par le ministre de la Défense nationale, 2011 Abstract …….. In recent years, Canadian law enforcement has attracted increased...initial step towards the creation of a Canadian Less Lethal Weapon (LLW) approval process, a workshop was held at Defence Research and Development

Practical Considerations of Design, Fabrication and Tests for Composite Materials,

DTIC Science & Technology

1982-09-01

ORGANIZATION ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT (ORGANISATION DU TRAITE DE L’ATLANTIQUE NORD) .1 AGARD Lecture Series No. 124...of Materials Science University of Bath Claverton Down Bath AB2 7AY UK SPEAKERS Dr A.R. Bunsell Dr J.J.Gerharz Ecole Naioiiale Sup~rieure des Fra...unhofer Institfit fuer Mines de Paris Betriebsfestigkeit (IBF) Centre des Mat~riaux Darmstadt Route Nationale 7, B.P. 87 Germany 91003 Evry Cedex France

Evaluation of Different Features for Face Recognition in Video

DTIC Science & Technology

2014-09-01

and Security Program (CSSP) which is led by Defence Research and Development Canada’s Centre for Security Science, in partnership with Public ...Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014...deployment of innovative technologies for public safety and security practitioners to achieve specific objectives; 4. Threats/Hazards F – Major trans-border

Using Sentence-Level Classifiers for Cross-Domain Sentiment Analysis

DTIC Science & Technology

2014-09-01

National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC...domain sentiment classification via spectral feature alignment. In Proceedings of the 19th international conference on World Wide Web, WWW ’10...Dennis, S. 5. DATE OF PUBLICATION (Month and year of publication of document.) September 2014 6a. NO. OF PAGES (Total containing information

Evaluation of Shelter Ventilation by Model Tests. Option 2

DTIC Science & Technology

1984-09-01

HUMUERS, 7449 N. Natchez Ave. FEMPL Work Unit 12.171 Niles, Illinois 60648 II. CONTROLLING OFFICE NAME AND ADDRESS IL REPORT DATE Federal Emergency...lights could be controlled through a voltage regulator. These lights 2-1 GARD ELEVATION VIEW Earth Berm Wndow 3’ x 3’ Winindow Interior of Shelter 32...Nationale 1 36 Rue J. B. Esch Luxembourg (Grand-Duche) Ministero dell Interno 1 Director General Protectione Civile Rome, Italy Civile Emergency Planning

The International System of Units (SI) in Oceanography. Report of IAPSO Working Group on Symbols, Units and Nomenclature in Physical Oceanography (SUN). Unesco Technical Papers in Marine Science 45. IAPSO Publication Scientifique No. 32.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Marine Sciences.

This report introduces oceanographers to the International System of Units (SI) in physical oceanography. The SI constitutes a universal language, designed to be understood by all scientists. It facilitates their mutual comprehension and exchange of views and results of their work. The first part of the report is devoted to physical quantities,…

Partager : des technologies de pointe au service de la société

ScienceCinema

None

2018-04-27

Médecine, climatologie, métrologie et informatique, les techniques utilisées par le LHC trouvent déjà des répercussions dans d’autres domaines scientifiques. Utilisant des techniques inédites, la physique des particules en fait bénéficier la société toute entière.

Manipulation of the Phase-Amplitude Coupling Factor in Quantum Nanostructure Based Devices for On-Chip Chirp Compensation and Low-Cost Applications

DTIC Science & Technology

2014-11-17

Compensation and Low -Cost Applications Frederic Grillot CTRE NAT DE LA RECHERCHE SCIENTIFIQUE 74, RUE DE PARIS CENTRE AFFAIRES OBERTHUR RENNES, 35000...of Scientific Research European Office of Aerospace Research and Development Unit 4515, APO AE 09421-4515 Distribution Statement A: Approved for...Amplitude Coupling Factor in Quantum Nanostructure Based Devices for On-Chip Chirp Compensation and Low -Cost Applications 5a. CONTRACT NUMBER

Torleif Ericson 60th Birthday

ScienceCinema

None

2017-12-09

Plusieurs discours à l'occasion du 60me anniversaire de Torleif Ericson, physicien né à Lund (Suède), et remerciements pour son travail et son effort de relier la physique des particules à la physique nucléaire. A la fin de la cérémonie un document scientifique de 400 pages "die Festschrift" lui est remis comme cadeau d'anniversaire avec un grand nombre de contributions d'amis etc...

Simulation of the CRIPT Detector

DTIC Science & Technology

2015-03-01

National Defence, 2015 c© Sa Majesté la Reine (en droit du Canada), telle que réprésentée par le ministre de la Défense nationale, 2015 Abstract The...iron slabs of the spectrometer. The red plates are the panels containing the scintillator bars. 3 3 Monte Carlo Geometry The geometry of the detector is...instead of hollow), • parts were in wrong location (eg. spectrometer iron plates). To fix this, Computer Aided Design ( CAD ) drawings were provided for

Discussion on the Modelling and Processing of Signals fom an Acousto-Optic Spectrum Analyzer.

DTIC Science & Technology

1987-06-01

AD-AIBS 639 DISCUSSION ON THE MODELLING AND PROCESSIN OF SIGNALS 1/1 FOR RN ACOUSTO - OPTIC SPECTRUM ANALYZER(U)G DFENCE RESERCH ESTABGLISHMENT OTTANA...8217’~ AV - I National DefenseI Defence nationale DISCUSSION ON THE MODELLING AND PROCESSING OF SIGNALS FROM AN ACOUSTO - OPTIC SPECTRUM ANALYZER by Guy...signals generated by an Acousto - Optic Spectrum Analyzer (AOSA). It also shows how this calculation can be related to pulse modu- lated signals. In its

Harbour Siren: Technical Recommendations Report

DTIC Science & Technology

2011-05-01

de recommandations et une feuille de route à court terme pour l’interopérabilité dans la gestion des urgences (IGU) et l’interopérabilité du système...Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC Atlantic CR 2010-179 i...maritime du Groupe de travail interministériel sur la sûreté maritime (GTISM). Le document présente un ensemble d’observations et de

Coalition Interoperability Measurement Frameworks Literature Survey

DTIC Science & Technology

2011-08-01

National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 Abstract...interarmées élabore actuellement ce cadre et les travaux sont parrainés par le Groupe du Sous- ministre adjoint ( Gestion de l’information). L’intérêt...Groupe du Sous-ministre adjoint ( Gestion de l’information). Le type d’interopérabilité qui nous intéresse : 1. touche les Cinq pays (Australie

Virtual Reality (VR) as a Disruptive Technology

DTIC Science & Technology

2011-07-01

gestion et l’emploi de la M & S en tant que ressource du ministère de la Défense nationale (MDN). Quels sont les principaux facteurs favorables...represented by the Minister of National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense...nous expliquerons comment la RV pourrait être mise au service de l’instruction militaire en répondant à des questions précises du

eSecurity Portfolio : Overview, Analysis of Value Added, and Way Ahead

DTIC Science & Technology

2014-11-01

de mesurer l’ampleur et la profondeur du portefeuille, en plus de consolider et de récapituler les produits livrables pour que les...Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC-2014-R113 i Abstract …….. The...ii DRDC-RDDC-2014-R113 Résumé …….. La communauté de pratique de la sécurité électronique du Centre des

Building Resilient Communities Workshop Report

DTIC Science & Technology

2014-06-01

Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 CSSP-2013-CD-1120...EMBC) [ Gestion des urgences Colombie-Britannique], le Programme canadien pour la sûreté et la sécurité (PCSS) et Recherche et développement pour la ...comptes rendus de la mise à jour du rapport du RCERD sur la résilience des communautés autochtones. L’événement a aussi donné une tribune pour un groupe

The Meta-Organization: A Research and Conceptual Landscape

DTIC Science & Technology

2011-06-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale...une approche globale en nous intéressant plus particulièrement aux problèmes pernicieux, à la convergence et à l’association, et à la gestion des ...rédigé dans le cadre du projet de modélisation de la collaboration et de la prise de décisions méta-organisationnelles financé par le

Development of Measures of Effectiveness and Performance from Cognitive Work Analysis Products

DTIC Science & Technology

2012-02-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC Atlantic CR 2011...le nouveau concept du système. Ce rapport vise à déterminer si les résultats du travail de conception peuvent aider à élaborer des mesures de ...l’information (IIDS). Le contrat actuel comportait deux objectifs : élaborer des mesures de l’efficacité (MOE) et du rendement (MOP) pour

V2010 Security Planning and Operations: A Social Network Study of Key Information Sharing Relationships

DTIC Science & Technology

2011-05-01

la scurit. Je vous remercie de votre temps et de votre contribution. Susan G. McIntyre Knowledge Management/ Gestion du savoir...National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC CSS TR 2011...avantages du renforcement de la communication horizontale au sein du gouvernement fédéral, surtout en présence d’organismes de

A PVDF Trigger and Tilt Detector for Projectile Impact Experiments

DTIC Science & Technology

1991-11-01

trigger include a fast rise time signal and a predictable signal magnitude. The circuit of a piezoelectric PVDF trigger is modeled in Figure 2-1; the...TR 91-640 DISTRIBUTION Copies Copies Chief of Naval Research Chairman Attn: ONR 1132P (R. Miller ) 1 Department of Defense Explosives ONT 20T (L. V...C. S. Coffey) 1 Washington, DC 20540 (J. Davis) 1 (D. L. Demske) 1 Socidth Nationale des Poudres (J. W. Forbes) 1 et Explosifs (R. H. Guirguis ) 1 Attn

Hierarchical Goal Analysis of Dynamic Decision Making in Microworld Experiments

DTIC Science & Technology

2009-03-01

7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS( ES ) Defence R&D Canada - Toronto,1133 Sheppard Avenue West,PO Box 2000,Toronto, Ontario, Canada M3M...3B9, 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS( ES ) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR...Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2009 DRDC Toronto TM 2008-211 i

Anthropomorphic Phantom Radiation Dosimetry at the NATO Standard Reference Point at Aberdeen Proving Ground,

DTIC Science & Technology

1987-04-01

and would still be well under 10(C. .% % p., I V a- E p - -12 - IABLE 8 (a) TLD results for phantom dosimetry - all values shown are measured charge...SAI. Conclusions The current DREO dosimetry system-consisting of bubble, CR39 and TLD dosimeters - has proven capable of producing meaningful results at...MC FILE CoPy’ Defence nationale 00 ANTHROPOMORPHIC PHANTOM RADIATION DOSIMETRY AT THE NATO STANDARD OREFERENCE POINT AT ABERDEEN PROVING GROUND by T

Technology Insertion and Management: Options for the Canadian Forces

DTIC Science & Technology

2010-01-01

Minister of National Defence, 2010 © Sa Majesté la Reine ( en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2010...semble indiquer qu’un changement de paradigme est en cours dans la façon dont les militaires élaborent et emploient la technologie à utiliser avec leurs...coûts-avantages fondée sur l’optimisation des options en matière d’insertion technologique. ii DRDC CORA TM 2010-015 This page

Likelihood Ratio Test Polarimetric SAR Ship Detection Application

DTIC Science & Technology

2005-12-01

menu. Under the Matlab menu, the user can export an area of an image to the MatlabTM MAT file format, as well as call RGB image and Pauli...must specify various parameters such as the area of the image to analyze. Export Image Area to MatlabTM (PoIGASP & COASP) Generates a MatlabTM file...represented by the Minister of National Defence, 2005 (0 Sa majest6 la reine, repr(sent(e par le ministre de la Defense nationale, 2005 Abstract This

Cesium cation templated selective synthesis of a "cone-shaped" sugar macrotricyclic cryptand: A dual anion-cation molecular recognition of potassium tartrate.

PubMed

Porwanski, S; Moretti, F; Dumarcay-Charbonnier, F; Marsura, A

2016-05-01

Cesium templated Staudinger-aza-Wittig tandem reaction (S.A.W.) has been used in the synthesis of a bis-diazacrown-bis-cellobiosyl-tetra-ureido cryptand. A novel macrotricyclic compound having a "cone-shaped" configuration was selectively obtained. Additionally, first results on potential recognition properties of the cryptand are also given. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Laser Safety Manual for DREO

DTIC Science & Technology

1993-11-01

milieu de travail securitaire dans les laboratoires de recherche utilisant de la radiation laser. L ’"American National Standard for the Safe Use of...d6fense nationale de poursuites l ~gales. i~i. I I EXECUTIVE SUMMARY Laser beams are currently used for some R&D activities at DREO. As laser radiation...par un appared as described in CFAO 66-4. must be strictly observed, laser peut provoquer des br-tilures de la reline et de la peau . Les mesures de

VENUS Ranging Study

DTIC Science & Technology

2014-12-01

Majesté la Reine (en droit du Canada), telle que réprésentée par le ministre de la Défense nationale, 2014 Abstract The underwater acoustic propagation...50 km des capteurs sous-marins situés aux nœuds du réseau VENUS dont les données acoustiques et sismiques sont accessibles au public sur Internet...Southwest British Columbia, Geophysical Journal International , 170(2), 800–812. [15] Hamilton, E. L. (1979), Vp/Vs and Poisson’s ratios in marine

Analysis of Metrics for Human Detection behind Walls Using Experimental 3-D Synthetic Aperture Radar Imagery

DTIC Science & Technology

2014-12-01

Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 Abstract …….. Defence Research and Development... International Symposium on Phased Array Systems and Technology, 551-558 (2010). [10] Chetty, K., Smith, G. E., Woodbridge, K., “Through-the-wall sensing of...radar,” IEEE International Conference on Communications and Signal Processing, 579-583 (2011). [13] Sévigny, P., DiFilippo, D., Laneve, T., Chan, B

3D Face Generation Tool Candide for Better Face Matching in Surveillance Video

DTIC Science & Technology

2014-07-01

Safety and Security Program (CSSP) which is led by Defence Research and Development Canada’s Centre for Security Science, in partnership with Public ...by the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale... public safety and security practitioners to achieve specific objectives; 4. Threats/Hazards F – Major trans-border criminal activity – e.g. smuggling

Simulation Tool for Optimizing Non-Combatant Evacuation (STONE): Optimization of Evacuation Time and Transportation Resource Utilization

DTIC Science & Technology

2015-05-01

2015 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2015 Abstract A Non-Combatant Evacuation...Standing Senate Committee on Foreign Affairs and International Trade recommended that more frequent assessments of NEO plans be conducted...étrangères et du commerce international a recommandé que des évaluations dans ses missions à l’étranger soient faites plus fréquemment

Experimental Evaluation of the IP Address Space Randomisation (IASR) Technique and Its Disruption to Selected Network Services

DTIC Science & Technology

2014-11-01

Canada (Department of National Defence), 2014 c© Sa Majesté la Reine en droit du Canada (Ministère de la Défense nationale), 2014 Abstract In recent...2006), Network security mechanisms utilising network address translation, International journal of critical infrastructures, 2(1), 10–49. [5] Dunlop...Lu, S. (2008), Full service hopping for proactive cyber-defense, In ICNSC 2008: IEEE International Conference on Networking, Sensing and Control, pp

A Bayesian Approach to Estimating Detection Performance in a Multi-Sensor Environment

DTIC Science & Technology

2014-09-01

National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC...emphasis can be seen in CF publications such as the Maritime Capability Planning Guidance (MCPG) 2010 [3]. To make effective use of these new remote...fixed installation, ship, aircraft, or satellite. Ships of a certain size or type are required by the International Maritime Organization (IMO) to

LRIT and AIS: An Analysis of October 2010 Data

DTIC Science & Technology

2014-10-01

Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC Atlantic TM 2012-234 i Abstract...There have been amendments in the recent decade to Chapter V of the 1974 International Convention for the Safety of Life at Sea (SOLAS) which is...des modifications ont été apportées au chapitre V de la Convention internationale de 1974 pour la sauvegarde de la vie humaine en mer (SOLAS), qui

Properties of Fuels Employed in a Gas Turbine Combustor Program.

DTIC Science & Technology

1983-09-01

potence nateonale PROPERTIES OF FUELS EMPLOYED IN A GAS TURBINE COMBUSTOR PROGRAM by .J.R. Coleman and L.D. Gallop JAN 1O t84’ La.I DEFENCE ROSOARCH...ESTABLISHMENT OTTAWA T~INCAMNTE M4 1-05 - ottwa , National Dibense3 Detence nationale PROPERTIES OF FUELS EMPLOYED IN A GAS TURBINE COMBUSTOR PROGRAM by...made of the physical and chemical properties of sixteen fuels employed in an aircraft gas turbine combustor programme. Several of these are specification

Assessment of Nuclear Medicine Capabilities in Responding to a Radiological Terrorism Event

DTIC Science & Technology

2006-09-01

Defence, 2006 © Sa Majesté la Reine , représentée par le ministre de la Défense nationale, 2006 DRDC Ottawa TM 2006-237 i Abstract...important suite à un tel incident. Il serait donc avantageux d’établir des points de contact officiels avec cette communauté, de développer du matériel...both didactic and clinical training. Didactic course work includes: mathematics, chemistry, physics, computer science, radiation protection, anatomy

Experimental Investigations on the Distortion of ISAR Images Using Different Radar Waveforms

DTIC Science & Technology

2003-09-01

des cibles fera partie int~grante d’une nouvelle approche pour la gestion des donn~es relatives A l’espace de combat, comme les nouvelles initiatives de ... risque de tir fratricide en conditions de combat. En somme, l’identification des cibles, particuli~rement en mode de non-cooperation, jouera un r~le...Defence, 2003 © Sa majest6 la reine, repr~sent~e par le ministre de la Defense nationale, 2003 Abstract Experimental results have shown that the

Canadian Journal of Physics. Volume 69, Number 2 (Revue Canadienne de Physique. Volume 69, Numero 2

DTIC Science & Technology

1991-02-01

4KNational Research Conseil national Council Canada de recherches Canada SMC CtRC Canadian Journal Revue canadienne of Physics de physique Volume 69...Number 2, February 1991 Volume 69, num~ro 2, W~rier 1991 AD-A235 711 Aviliable for $36.00 from National Research Council of Canada, Ottawa, Ont...Publid par THE NATIONAL RESEARCH COUNCIL OF CANADA LE CONSEIL NATIONAL DE RECHERCHES DU CANADA Editor R. W. NICHOLLS Directeur scientifique Editorial

A Research Agenda for Scientific and Technical Information Held in Lisbon, Portugal on 7-9 April 1992 (Un Programme de Recherche pour l’Information Scientifique et Technique).

DTIC Science & Technology

1992-11-01

field of inquiry. Good solid research advances fault library science and information science for not ask- the state of the art by contributing to the...further research and application. Ennis (1967) problems faced each day by practitioners. Robert Smith commented that library science research is...under ogy, and technical communications. Library science the title "On Information Science." Keren raises interest- and information science have been

Specialists Meeting on Helicopter Design Mission Load Spectra

DTIC Science & Technology

1976-08-01

partement Scientifique AEROSPATIAI*E - B.P n0 13 13 722 -AINN 1I INTRODUCTION Si 1e princips g~ndral de d~tarmination des dur~ea de vie des pibcea d’h...reprdsentatives de l’utilisation h 6valuer un certain nombro do jauges.extensom~triques. Coa jauges , placgos sur chacun des 4ldmonte critiquos au point do Vuo...sensitivity. 1. INTRODUCTION The design of the fatigue critical components of a helicopter, which are mainly the blades, the hub, and the drive system

Opticien Célèbre. André Maréchal

NASA Astrophysics Data System (ADS)

Haidar, Riad

2017-12-01

Physicien français spécialisé en optique, professeur à la faculté des sciences de l'université de Paris, André Maréchal a également été délégué général à la recherche scientifique et technique, et directeur général de l'Institut d'Optique. On lui doit notamment des résultats remarquables sur la théorie des aberrations et de la diffraction.

What Should Users Expect from Information Storage and Retrieval Systems of the 1980’s

DTIC Science & Technology

1981-12-01

cide dcentrer sur ls marchE de l1information secondaire, on doit d~finir Is secteur , rschercher des appuis (coop~rants) pour couvrir cc secteur ...inutiles. Ii appartient bien entendu chaque Gouvernemant dlapprdcier sea prioritds, mais en se plagant dans Is cadre tracE. GOUVERNEMENT ET SECTEUR PRIVE A...directive A76 salon laqualle le Gouvernament f~d~ral slappuiera sur Is secteur priv6 pour publiar at dissminar llinformation scientifique at technique

IEEE International Symposium Information Theory, held at Santa Monica California, February 9-12, 1981.

DTIC Science & Technology

1981-01-01

Channel and study permutation codes as a special case. ,uch a code is generated by an initial vector x, a group G of orthogonal n by n matrices, and a...random-access components, is introduced and studied . Under this scheme, the network stations are divided into groups , each of which is assigned a...IEEE INFORMATION THEORY GROUP CO-SPONSORED BY: UNION RADIO SCIENTIFIQUE INTERNATIONALE IEEE Catalog Number 81 CH 1609-7 IT 𔃻. 81 ~20 04Q SECURITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Plusieurs orateurs rendent hommage au grand physicien et scientifique Vladimir Jurko Glaser (1924 - 1984) qui travaillait au Ruder Boscovic Institut à Zagreb avant de venir au Cern en 1957 où il trouvait un poste permanent au département de physique théorique. Walter Tearing, Harry Lehmann,Henry Epstein, Jacques Bros et André Martin font des résumés biographiques de leurs collègue et ami en honorant ses grands qualités d'homme et ses remarquables conquêtes de la science et leurs accomplissement.

Methodology for Assessing Disruptions (MAD) Game Part I: Report and Analysis

DTIC Science & Technology

2012-12-01

élaborées dans le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du...le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du scientifique en...2010 2012-009 Principal Author Original signed by G . Adlakha-Hutcheon, M. Hazen, P. Hubbard, S. McLelland, K. Sprague G . Adlakha

Forward Air Controller: Task Analysis and Development of Team Training Measures for Close Air Support

DTIC Science & Technology

2007-12-01

responsable scientifique aux fins d’examen et d’incorporation dans la planification de l’exercice Northern Goshawk, une simulation répartie d’une opération...L. K. (Eds.) (1992). A guide to task analysis. London, UK: Taylor & Francis. Matthews, M. L. and Lamoureux, T . M. (2003). Development of Generic...for Close Air Support Operations (ATP-3.3.2.1(A)). Brussels, Belgium. Silverman, D. R., Spiker, V. A., Tourville, S. J., and Nullmeyer, R. T . (1997

The Impact of Changing International Relations on the Scientific and Technical Community (Incidence sur la Communaute Scientifique et Technique des Transformations en cours dans les Relations Internationales.

DTIC Science & Technology

1993-04-01

Processing of special formats (diagrams, tables) - Determination of words to be Pre-analysis Programs added to system dictionary Dictionary ...language Lexicon combinations, via a standardized interface (MIR) which maps METAL operates -n both monolingual lexicons and one the results of analyses...in uniform ways. transfer lexicon for each language pair. The monolingual lexi- Unfortunately, there is at present no linguistic theory which cons

Démarche pour la mise à niveau d’un secteur de soins pharmaceutiques : le cas de l’hémato-oncologie pédiatrique

PubMed Central

Bussières, Jean-François; Robelet, Antoine; Therrien, Roxane; Touzin, Karine

2010-01-01

Contexte : Bien que le concept de pharmacie clinique ait été développé dans les années soixante, il existe une grande variété de programmes et une grande disparité entre les programmes en clinique externe et en hospitalisation, bénéficiant de la présence d’un pharmacien dans un secteur de soins. Objectif: Éprouver une méthode de mise à niveau des secteurs de soins pharmaceutiques en établissement de santé. Méthode : Il s’agit d’une étude descriptive se déroulant au Centre hospitalier universitaire Sainte-Justine, un établissement mère-enfant de 500 lits. Le secteur de soins pharmaceutiques ciblé pour illustrer la méthode de mise à niveau est l’hématologie-oncologie pédiatrique. La méthode comporte trois étapes, soit une revue de la documentation scientifique, un profil du secteur et une mise à jour du niveau de pratique selon un profil des activités pharmaceutiques dans le secteur avant et après la mise à niveau. Résultats : Au total, 108 articles ont été recensés et 22 ont été retenus à partir d’une recherche dans PubMed. Après une recherche manuelle complémentaire, 36 articles ont finalement été évalués. Parmi les articles retenus, on compte trois lignes directrices, 11 études de développement, une revue de la littérature scientifique, six études pré- et post-interventions et 15 études quasi expérimentales. Bien que les patients de ce secteur ne comptent que pour 5 % des admissions de l’hôpital, la complexité des cas est élevée tant sur le plan de la codification de l’épisode de soins que du potentiel d’intervention pharmaceutique par admission. Conclusion : Il existe peu de données illustrant une démarche de mise à niveau de la pratique dans un secteur de soins pharmaceutiques. Cette étude a éprouvé une méthode de mise à niveau dans un service d’hématologie-oncologie pédiatrique et comporte une revue de la documentation scientifique, un profil du secteur et une description des tâches des pharmaciens de ce secteur avant et après la mise à niveau. PMID:22478967

C6 GPMG and 40 mm AGL Weapon Integrated on RWS Mounted on TAPV Platform: Probability of Hit Methodology

DTIC Science & Technology

2010-09-01

nationale, 2010 DRDC Valcartier CR 2010-237 i Abstract …….. A probability of hit ( PHit ) methodology has been developed to characterize the...CFB (Canadian Forces Base). Résumé …..... Une méthodologie de probabilité d’impact ( PHit ) a été développée pour caractériser la performance globale...the crew commander and gunner from their respective crew stations inside the vehicle. A probability of hit ( PHit ) methodology has been developed to

Optimal Alignment of Search and Rescue Response Posture with Historical Incident Occurrence

DTIC Science & Technology

2014-04-01

and Development Canada Scientific Report DRDC-RDDC-2014-R12 April 2014 © Her Majesty the Queen in Right of Canada, as represented by the Minister of...National Defence, 2014 © Sa Majesté la Reine en droit du Canada, telle que représentée par le ministre de la Défense nationale, 2014 Abstract The ...hour response posture (RP2hrs) for remaining hours. This report details the data, modelling and analysis for optimizing CAF SAR RP30 hours. Based on

Study on Cyber Security and Threat Evaluation in SCADA Systems

DTIC Science & Technology

2012-03-01

la sécurité de l’infrastructure essentielle du Canada. DRDC CSS CR 2012-06 vii • Les cadres de gestion des cybermenaces et des ...Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC CSS CR 2012-06 i Abstract …….. This...ii DRDC CSS CR 2012-06 Résumé …..... Le présent rapport fait la synthèse des résultats du projet PTSP 02-0347eSec

Toward the Development of a Canadian Less Lethal Weapon Approval Process: A Study of Contemporary Process Models

DTIC Science & Technology

2011-10-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011...validés par l’autorité d’approbation. Lorsqu’il n’existe pas de normes officielles, on utilise une approche de gestion du risque qui comprend une plus...gouvernance qui reprend les éléments clés du modèles du Royaume-Uni, l’incorporation d’un processus de gestion du risque, un énoncé des

Current Flow Through Two Dimensional Arrays of Metal Nanoparticles as a Novel Sensor Platform

DTIC Science & Technology

2009-05-01

Suffield TM 2009-068; R & D pour la défense Canada – Suffield; août 2009. Les indicateurs d’exposition de type macarons sont une composante essentielle...fait que ces films de nanoparticules sont très at- trayants comme génération future des indicateurs d’exposition de type macaron personnel. Les ...Minister of National Defence, 2009 c© Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale

LL and E awarded E and D contract area in eastern Algeria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-12-07

This paper reports that a Louisiana Land and Exploration Co. unit has been awarded on exploration and production contract in Algeria by state oil company Enterprise Nationale Sonatrach. LL and E Algeria Ltd.'s contract covers two blocks in the central Ghadames oil basin of eastern Algeria. LL and E said the contract, yet to be submitted for government approval, calls for a minimum investment of $33 million during a 5 year work program that includes seismic acquisition and drilling a minimum of three wildcats.

A Two-Ended Shooting Technique for Calculating Normal Modes in Underwater Acoustic Propagation,

DTIC Science & Technology

1985-09-01

tnad~ I’or Public rL.00uq cmd ina ts 85 12 _ 8 126 UNLIMITED DISTRIBUTION * I ’ National Defence Defense Nationale Research and Bureau de Recherche...d6crit un algorithme de calcul des modes acoustiques normaux en mer. L’algoritbme est applicable & un prof il arbitraire do densit6 et do vitesse du son... profondeur do roncontre au milieu, habituellement pr&s du point do vitesse du son minimum. on amfiliore par it~ration la solution dlesaai jusqu’& ce

Technologies for Protection and Resistance Enhancement of Critical Infrastructures againstExtreme Fire

DTIC Science & Technology

2014-05-01

in Right of Canada, as represented by the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ...extreme fire protection of critical infrastructures. Résumé …..... Le présent rapport fournit de l’information qui pourrait aider à élaborer des...démarches nationales pour une atténuation du risque émergeant des conditions d’incendie extrêmes pour les infrastructures essentielles (IE). Les résultats

The French Polemic: Nationalism, Racism and Atlanticism in the Past, Present and Future

DTIC Science & Technology

1993-12-01

where the climate and topography are very similar to that of their nation of origin. "󈧔Rapport de la Commission Nationale Consultative des Droits de ...Interpreting the French Revolution, Editions de !a Maison des Sciences de 1’ Homme , 1981. Gobineau, A., The Inequality of Human Races, Howard Fertig...8 0 jL .13 6. L -25-11 1 i1J8 74 0 > /NS BY PPPLIEO IMPGE, INC. Wihtol de Wenden, C., "North African Immigration and the French Political imaginary

Findings of the Test and Evaluation Proof of Concept Trial at the NCOT Facility

DTIC Science & Technology

2002-04-01

Submitted by: M. L . Matthews, R. D. G. Webb, A. R. Keeble Humansystems Incorporated® 111 Farquhar Street, 2nd Floor Guelph, Ontario N1H 3N4 Project...Report DRDC- Toronto No. CR-2002-056 Q\\ l Humansystems Incorporated April2002 NCOT: Proof of Concept P517839.PDF [Page: 4 of 39] ~· ©HER MAJESTY THE...QUEEN IN RIGHT OF CANADA (2002) as represented by the Minister of National Defense ©SA MAJESTE LA REINE EN DROIT DUE CANADA (2002) Defense Nationale

An investigation of the Attenuation Provided by the Surefire EP3 Sonic Defender (Trademark) Earplug

DTIC Science & Technology

2008-05-01

Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2008 DRDC Toronto TR 2008-040 i Abstract...Surefire chez cinq hommes et cinq femmes. Selon le fabricant, un orifice percé dans le bouchon permet aux sons dont le niveau est sans danger de ...dispositif avec l’orifice ouvert et fermé en l’absence de bruits impulsifs. Cinq hommes et cinq femmes y ont participé. Le seuil d’audibilité de chaque

Spectra of M Asteroids V1.0

NASA Astrophysics Data System (ADS)

Fornasier, S.; Clark, B. E.; Migliorini, A.; Ockert-Bell, M.

2011-08-01

This data set contains reduced composite visual and near-infrared spectra of thirty M-type asteroids, observed over the years 2004-2008 and presented in Fornasier et al. (2010). The spectra were taken with the Dolores and NICS instruments at the Telescopio Nationale Galileo (TNG) in La Palma, with the EMMI and SOFI instruments at the ESO New Technology Telescope (NTT) in Chile, and with the SPeX instrument at the Infrared Telescope Facility (IRTF) in Hawaii. The individual spectra from the various instruments used to produce the composite spectra are also included.

Power Analysis for a Proposed Group Randomized Control Trial (GRCT) on the Road to Mental Readiness (R2MP) Program

DTIC Science & Technology

2014-08-01

the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale...specifically for the target GRCT population. The internal consistency and factorial validity of this new measure has been established in a series of studies...measure. Journal of general internal medicine. 2001;16(9):606-13. [11] Richards K, Fikretoglu D. Using Administrative Data to Inform the Design of a

Biometrics of Intent: From Psychophysiology to Behaviour

DTIC Science & Technology

2009-11-01

pourrons comparer les profils de sujets individuels avec la base de données normatives. La mise sur pied de cette banque de données constitue donc la...of National Defence, 2009 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2009 DRDC...intentionnel des états émotionnels négatifs engendrés par le stress. Ce qui est proposé ici, c’est un cadre théorique préliminaire qui applique les

Mid-wave IR Signatures of CFAV Quest in the North Atlantic Summer and Winter Climates

DTIC Science & Technology

2008-05-01

hiver, ce qui laisse supposer qu’elle pose un plus grand risque de détection du navire. DRDC Atlantic TM 2007-312 i This page intentionally left blank...consacrer ses efforts de gestion des signatures infrarouge. L’objectif final de l’obtention d’un moyen d’optimiser la signature infrarouge des navires...que représentée par le ministre de la Défense nationale, 2008 Original signed by Zahir A. Daya Original signed by Dave Hopkin Original signed by Ron

Minutes of the Explosive Safety Seminar (18th) Held at San Antonio, Texas on 12-14 September 1978. Volume 2

DTIC Science & Technology

1978-09-14

AT THE PONT- DE -BUIS GUN-POWDER FACTORY ON 7TH AUGUST 1975 1089 Mr. Jean Quinchon EXPLOSIVE INCIDENT DURING DEMOLITION GROUND OPERATIONS 1097 Mr...OCCURRED AT THE PONT- DE -BUIS GUN-POWDER FACTORY ON 7TH AUGUST 1975 Mr. Jean Quinchon Societe Nationale Des Poudres Et Explosifs Paris, France The...Pont- de -Buis National Gun-Powder Factory in the department of Finistere was built in the reign of LOUIS XIV to supply the Brest naval dock-yards

Design and Test Results of AMIGO: A Novel Remote Ground Sensor System

DTIC Science & Technology

2007-01-01

prix ou dans l’IR à prix élevé); le corps principal équipé de capteurs et de composants électroniques de base à faible prix ; et une plate-forme...reine, représentée par le ministre de la Défense nationale, 2007 DRDC Valcartier TR 2005-272 i Abstract The objectives of the project...Observation) a pour but d’étudier les technologies relatives aux systèmes de détecteurs autonomes au sol (DAS) et de mettre au point, puis de

Atrophie cérébrale diffuse au cours d'un syndrome de Goldenhar: à propos d'un cas

PubMed Central

Asani, Yogolelo; Mulenga, Cilundika; Ngombe, Léon Kabamba; Mbuyi-Musansayi; Muenze, Kalenga; Borasisi, Chenge; Speeg-Schatz

2014-01-01

Les auteurs rapportent un cas d'un syndrome de Goldenhar non décris dans la littérature chez un nourrisson de 3 mois, de sexe féminin présentant une atrophie cérébrale diffuse. Cette observation permet de décrire cette malformation rare et d'attirer l'attention de l'opinion scientifique à mettre en marche des études poussées afin de comprendre la survenue de cette pathologie. PMID:25767659

The Psychology of Violent Conflict in Failing States: A Review of the Scientific Literature (Psychologie des Conflits Violents au sein d’etats en Deroute: Analyse de Publications Scientifiques)

DTIC Science & Technology

2010-12-01

however, was the possibility for students to choose the role of insurgents. Two weeks prior to the start of the simulation, the 78 undergraduate ...King, 2009), students in a political science class participated in a week-long simulation of large-scale regional insurgency. Before the simulation... Students could choose to be government officials, such as the president or the secretary of defence of a country. Alternatively students could role-play

Foreword

NASA Astrophysics Data System (ADS)

Brazovskii, Serguei; Dressel, Martin; Kirova, Natasha

2015-03-01

This volume presents a collection of articles based upon materials of the recent International School and Workshop on Electronic Crystals, ECRYS-2014. The series ECRYS was founded by Serguei Brazovskii and Pierre Monceau in 1993. ECRYS-2014 is the seventh in the sequence of such events, held in France every three years; the last four meetings 2005, 2008, 2011 and 2014 were hosted by the Institut d'Etudes Scientifiques of the CNRS, at Cargese, Corsica, France. Starting from 2011, ECRYS was expanded to a two-week format incorporating summer-school type tutorials of renowned scientists.

Sleep and Modeled Performance of Arctic Patrollers during Operation Nunalivut 2010

DTIC Science & Technology

2011-07-01

Paul, M. A., Gray, G . W., Nesthus, T . E., and Miller, J. C. (2008). An assessment of the cf submarine watch schedule variants for impact on modeled crew...Consideration of 5 canadian forces fire-fighter shift schedules. (TR 2005-027). [8] Arnedt, J. T ., Wilde, G . J. S., Munt, P. W., and MacLean, A. W. (2001...l’Arctique, il est fortement souhaitable que les scientifiques du MDN soient invités à participer aux phases de planification de toutes les opérations dans

N° 341-Diagnostic et prise en charge de la torsion annexielle chez les filles, les adolescentes et les femmes adultes.

PubMed

Kives, Sari; Gascon, Suzy; Dubuc, Élise; Van Eyk, Nancy

2017-02-01

Passer en revue les connaissances scientifiques actuelles et formuler des recommandations relatives au diagnostic et à la prise en charge de la torsion annexielle chez les filles, les adolescentes et les femmes adultes. L'étude porte sur les facteurs de risque, la précision diagnostique, les options de prise en charge et les issues de la torsion annexielle. RéSULTATS: Nous avons examiné les études publiées en faisant des recherches dans MEDLINE, Embase, CINAHL et la Bibliothèque Cochrane à l'aide d'une terminologie contrôlée et de mots-clés appropriés (« adnexal torsion », « ovarian torsion »). Nous avons limité les résultats aux revues systématiques, aux essais contrôlés aléatoires, aux essais cliniques contrôlés et aux études d'observation. Nous avons refait les recherches de façon régulière et intégré de nouvelles données à la directive jusqu'en décembre 2014. Nous avons également étudié la littérature grise (non publiée) trouvée sur les sites Web d'organismes d'évaluation des technologies de la santé et d'autres organismes connexes, dans des collections de directives cliniques et dans des registres d'essais cliniques, et obtenue auprès d'associations nationales et internationales de médecins spécialistes. Les résultats ont été examinés et évalués par le comité CANPAGO de la Société des obstétriciens et gynécologues du Canada (SOGC), sous la direction des auteures principales. Les recommandations ont été classées selon les critères établis par le Groupe d'étude canadien sur les soins de santé préventifs. AVANTAGES, DéSAVANTAGES ET COûTS: L'application de la directive devrait aider les praticiens à adopter une approche de diagnostic et de prise en charge optimale en matière de torsion annexielle, à réduire au minimum les effets néfastes et à améliorer l'issue qui attend les patientes. La présente directive a été évaluée et approuvée par le Comité de pratique - gynécologie de la SOGC, et approuvée par le Conseil de la SOGC. Parrainé par la Société des obstétriciens et gynécologues du Canada. DéCLARATIONS SOMMAIRES: RECOMMANDATIONS. Copyright © 2017. Published by Elsevier Inc.

Deutsches "Nationales Krebshilfe-Monitoring" 2015-2019 - Studienprotokoll und erste Ergebnisse.

PubMed

Schneider, Sven; Görig, Tatiana; Schilling, Laura; Breitbart, Eckhard W; Greinert, Rüdiger; Diehl, Katharina

2017-09-01

Das Projekt "Nationales Krebshilfe-Monitoring zur Solariennutzung" (National Cancer Aid Monitoring of Tanning Bed Use, NCAM) ist eine deutsche Großstudie mit dem Ziel, die wichtigsten Risikofaktoren für Hautkrebs zu beobachten: natürliches Sonnenlicht und künstliche UV-Strahlung. NCAM ist eine bundesweite Querschnittstudie mit zunächst vier Runden der Datenerfassung (sogenannten Wellen) zwischen 2015 und 2018. Jedes Jahr wird eine bundesweit repräsentative Stichprobe aus 3.000 Personen im Alter von 14 bis 45 Jahren befragt. Die Querschnittsbefragung wird durch eine Kohorte von n = 450 aktuellen Solariennutzern ergänzt. Die erste Welle im Jahr 2015 ergab eine Gesamtprävalenz der Solariennutzung von 29,5 %. Elf Prozent aller Teilnehmer hatten in den vergangenen zwölf Monaten ein Solarium genutzt. Zu den Determinanten der aktuellen Solariennutzung gehörten jüngeres Alter, weibliches Geschlecht und Vollzeit-/Teilzeitbeschäftigung. Die hauptsächlichen Beweggründe, die für die Nutzung eines Solariums genannt wurden, waren Entspannung und Attraktivitätssteigerung. NCAM ist weltweit die erste Studie zur Überwachung der Risikofaktoren für Hautkrebs in jährlichen Intervallen anhand einer großen, landesweit repräsentativen Stichprobe. Erste Ergebnisse deuten darauf hin, dass Millionen Deutsche trotz Warnungen der WHO Solarien nutzen, und dass viele dieser Nutzer Jugendliche sind - trotz gesetzlicher Beschränkungen, die das Ziel haben, die Nutzung von Solarien durch Minderjährige zu verhindern. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

CONFERENCE NOTE: Conference on Precision Electromagnetic Measurements

NASA Astrophysics Data System (ADS)

1991-01-01

The next Conference on Precision Electromagnetic Measurements (CPEM), will be held from 9 to 12 June 1992 at the Centre des Nouvelles Industries et Technologies (CNIT), La Défense, Paris, France. This conference, which is held every two years and whose importance and high level, confirmed by thirty years' experience, are recognized throughout the world, can be considered as a forum in which scientists, metrologists and professionals will have the opportunity to present and compare their research results on fundamental constants, standards and new techniques of precision measurement in the electromagnetic domain. Topics The following topics are regarded as the most appropriate for this conference: realization of units and fundamental constants d.c. a.c. and high voltage time and frequency radio-frequency and microwaves dielectrics, antennas, fields lasers, fibre optics advanced instrumentation, cryoelectronics. There will also be a session on international cooperation. Conference Language The conference language will be English. No translation will be provided. Organizers Société des Electriciens et des Electroniciens (SEE). Bureau National de Métrologie (BNM) Sponsors Institute of Electrical and Electronics Engineers (IEEE) Instrumentation & Measurement Society Union Radio Scientifique Internationale United States National Institute of Standards and Technology Centre National d'Etudes des Télécommunications Mouvement Français pour la Qualité, Section Métrologie Comité National Français de Radioélectricité Scientifique Contact Jean Zara, CPEM 92 publicity, Bureau National de Métrologie, 22, rue Monge, 75005 Paris Tel.: (33) 1 46 34 48 16, Fax: (33) 1 46 34 48 63

Celestial Treasury

NASA Astrophysics Data System (ADS)

Lachièze-Rey, Marc; Luminet, Jean-Pierre

2001-07-01

Throughout history, the mysterious dark skies have inspired our imaginations in countless ways, influencing our endeavors in science and philosophy, religion, literature, and art. Filled with 380 full-color illustrations, Celestial Treasury shows the influence of astronomical theories and the richness of illustrations in Western civilization through the ages. The authors explore the evolution of our understanding of astronomy and weave together ancient and modern theories in a fascinating narrative. They incorporate a wealth of detail from Greek verse, medieval manuscripts and Victorian poetry with contemporary spacecraft photographs and computer-generated star charts. Celestial Treasury is more than a beautiful book: it answers a variety of questions that have intrigued scientists and laymen for centuries. -- How did philosophers and scientists try to explain the order that governs celestial motion? -- How did geometers and artists measure and map the skies? -- How many different answers have been proposed for the most fundamental of all questions: When and how did Earth come about? -- Who inhabits the heavens--gods, angels or extraterrestrials? No other book recounts humankind's fascination with the heavens as compellingly as Celestial Treasury. Marc Lachièze-Rey is a director of research at the Centre National pour la Récherche Scientifique and astrophysicist at the Centre d'Etudes de Saclay. He is the author of The Cosmic Background Radiation (Cambridge, 1999), and and The Quest for Unity, (Oxford, 1999 ), as well as many books in French. Jean-Pierre Luminet is a research director of the Centre National pour la Rechérche Scientifique, based at the Paris-Meudon observatory. He is the author of Black Holes, (Cambridge 1992), as well as science documentaries for television.

Optimal RSOM-hub Locations for Northern Operations: A MAJAID Scenario Analysis

DTIC Science & Technology

2011-08-01

droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 Abstract …….. This paper presents an analysis of a...militaires et les opérations de maintien en puissance. Au cours de cette étude, les mesures de rendement ont été établies en vue d’évaluer l’efficacité...analyse plus approfondie des données réelles devrait être menée. • Au cours de l’analyse, la simulation du transport tactique était fondée sur le CH146

Engine Fluid Leakage Detection: A Feasibility Study

DTIC Science & Technology

2011-07-01

2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC Atlantic TM 2011-050 i... de détecter tout problème possible lié à la sécurité ou aux performances des moteurs à turbine à gaz d’aéronefs. Le signalement immédiat d’une fuite...carburant ou d’huile moteur nuisent non seulement aux performances d’un moteur, mais elles représentent également une menace réelle pour la sécurité de

Validation of New Crack Monitoring Technique for Victoria Class High-Pressure Air Bottles

DTIC Science & Technology

2014-06-01

technique de corrélation d’images numériques a été employée pour mesurer le champ de déforma- tion dans la zone située du côté opposé à l’entaille... la Reine en droit du Canada (Ministère de la Défense nationale), 2014 Abstract High-pressure air bottles are used in the Victoria class submarines to...charges cycliques pouvant provoquer l’apparition et favoriser la croissance de fissures de fatigue. L’ob- servation d’une marque interne semblable à une

Research Using In Vivo Simulation of Meta-Organizational Shared Decision-making (SDM). Task 4: Modeling of Communication and Decision Functions within a Shared Decision-making (SDM) Framework

DTIC Science & Technology

2011-12-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale 2011, Abstract...modélisation des fonctions de communication et de prise de décision dans le cadre de la prise de décision partagée (PDP) du volet de travail « Recherche par... la simulation in-vivo sur la prise de décision partagée des méta-organisations ». Cette composante du programme

Status of Day Care in Canada, 1984: A Review of the Major Findings of the National Day Care Study, 1984 = Situation de la garde de jour au Canada, 1984: Revue des principales conclusions tirees de l'etude nationale menee en 1984 sur la garde de jour.

ERIC Educational Resources Information Center

National Day Care Information Centre, Ottawa (Ontario).

Intended to give Canadians a general overview of the country's day care services, the study was undertaken by the Social Service Programs Branch, Health and Welfare, Canada. Begun in 1971 and updated yearly since 1973, the national survey provides an inventory of day care spaces which can be used to measure future growth in day care and to…

Status of Day Care in Canada, 1983: A Review of the Major Findings of the National Day Care Study, 1983. = Situation de la garde de jour au Canada, 1983: Revue des principales conclusions de l'etude nationale sur la garde de jour en 1983.

ERIC Educational Resources Information Center

National Day Care Information Centre, Ottawa (Ontario).

The major purpose of the Status of Day Care in Canada reports is to gather information from the provinces concerning day care spaces in order to determine the growth of day care from year to year. In addition to reporting the increase in the availability of day care services from 1973 to 1983, this report provides data on the ages of children…

[Pachymeningitis].

PubMed

Fain, O; Mekinian, A

2017-09-01

Pachymeningitis is a fibrosing and inflammatory process, which involves the dura mater. Some pachymeningitis are cranial and induce headaches and cranial nerve palsies. Others are spinal and responsible for nerve roots or spinal cord compression. MRI shows contrast enhancement thickening of the dura mater. Etiologies are infectious (syphilis, tuberculosis, etc.) or inflammatory (sarcoidosis, granulomatosis with polyangiitis, IgG4-related disease, idiopathic). Corticosteroids are the main treatment. The use of immunosuppressive drugs or rituximab is yet to be determined and probably adapted to each etiology. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Contractor Final Report: For the Technology Demonstration of the Joint Network Defence and Management System (JNDMS)

DTIC Science & Technology

2013-10-01

opérationnel. Importance: Nous avons démontré des fonctions cruciales en utilisant des outils d’entreprise pour comprendre en profondeur un domaine...by the Minister of National Defence, 2009 © Sa Majesté la Reine ( en droit du Canada), telle que représentée par le ministre de la Défense nationale...interarmées de défense et de gestion des réseaux (SIDGR), en vertu du contrat W7714-04-0875/001/SV. Il touche l’exécution et les résultats de cette

Telemetre Laser a Onde Entretenue a 10.6 micrometers avec Postdetection non Lineaire: Etude d’un Systeme a un Laser (A 10.6 micrometer Amplitude Modulated Telemeter Laser with Nonlinear Postdetection: Study of a Single Laser System),

DTIC Science & Technology

1981-04-01

Courbes de variation de u et de la profondeur de modulation a en fonction de la tension appliquge V FIGURE - 4 jo NON CLASSIFIE 14 On peut donc...ET DEVELOPPEMENT RESEARCH AND DEVELOPMENT BRANCH MINISTERE DE LA DEFENSE NATIONALE UNCLASSIFIED DEA CETO AINADEFNC CANADA UNI. IMITED DISTRIBUTiIN CND...RECHERCHES POUR LA DEFENSE DEFENCE RESEARCH ESTABLISHMENT VALCARTIER Tel: (418) 844-4271 Quebec, Canada April/avril 1981 UNCLASSIFIED, /41/7z *I .. , NON

[Unusual leukoencephalopathy of post-partum].

PubMed

Hsaini, Y; Karouache, A; Bourazza, A

2011-08-01

Neurologic complications of post-partum are serious and usually secondary to eclampsia or stroke. We here report a 26-year-old female who presented with severe headaches, blurred vision, and repeated generalized seizures secondary to posterior reversible encephalopathy that occurred after a caesarean section for fetal death in utero. Outcome was favourable. Although uncommon, this neurologic complication of the post-partum should be discussed in the presence of any sign of encephalopathy occurring in the context of acute hypertension. Copyright © 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Tailoring Wettability Through the Surface Modification of Electro-spun Polymers by Plasma and Sol-gel Treatments

DTIC Science & Technology

2014-11-01

Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2014 DRDC-RDDC-2014-R102 i...avec la surface des matériaux est d’une importance fondamentale pour de nombreux processus, dont l’adhésion, les réactions chimiques, le transport...hydrodynamique et la nettoyabilité des surfaces. Les propriétés des surfaces peuvent se situer dans une gamme allant d’un caractère hydrophile ou

Resilience of Critical Infrastructure to Extreme Fires - Gaps and Challenges

DTIC Science & Technology

2014-04-01

du Canada), telle que représentée par le ministre de la Défense nationale, 2014 3 Abstract …….. This report provides the results of the study...the results of the two fire tests. Résumé …..... Le présent rapport fournit les résultats de l’étude menée par le Conseil national de recherches du...d’entreposage de carburants ou de véhicule-citerne. L’effondrement des tours du World Trade Centre, le 11 septembre 2001, et celui de l’échangeur du pont

Optical Disk Technology and the Library. Part 1: The Technology and Its Applications. Part 2: The National Library Videodisc Demonstration Project. Canadian Network Papers Number 9 = Technologie du Videodisque et la Bibliotheque. Premiere partie: La Technologie et ses Applications. Deuxieme partie: Projet de Demonstration du Videodisque a la Bibliotheque Nationale. Documents sur les Reseaux Canadiens Numero 9.

ERIC Educational Resources Information Center

Duchesne, Roddy; Sonnemann, Sabine S.

This report is intended to assist Canadian libraries in assessing potential library applications of optical disk technology. Part 1 provides a general outline of the technology and describes a number of library applications and projects. Descriptions are purposely general and illustrative in nature since the technology and its applications are…

International Workshop on Advances in Inorganic Fibre Technology Held in Melbourne, Australia on August 13 - 14, 1992

DTIC Science & Technology

1992-08-14

o Air -cured 0 1-Octyne-cured,/ S1-Hexyne I -cured 1 10- E C 5 011 0 L I I I 1200...1825 °C o TWS-400, 2h * TWS-400, 4h 52 INORGANIC FIBRES FOR CDMPOSITE MATERIALS A.R. BUNSELL Ecole Nationale Sup6rieure des Mines de Paris Centre des ...7stalblishm~ent in U.K. It was soon estab.li sheia -t1at .uazlit; of ?M precursor ani o temperatUra ther.:-A3_ stubilisation con iition3 are - tw.. o

The Concentration Probability Density Function With Implications for Probabilistic Modeling of Chemical Warfare Agent Detector Responses for Source Reconstruction

DTIC Science & Technology

2008-05-01

efforts de gestion rétroactive des situations d’urgence actuelles comportant l’mission cachée d’agents chi- miques, biologiques et radiologiques (CBR...Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2008 Original signed by E. Yee Original...context of the source reconstruction problem. DRDC Suffield TR 2008-077 i Résumé On a étudié les relations entre des moments variés de

Finite Elements, Design Optimization, and Nondestructive Evaluation: A Review in Magnetics, and Future Directions in GPU-based, Element-by-Element Coupled Optimization and NDE

DTIC Science & Technology

2013-07-18

Nationale Supérieure d’Ingénieurs Electriciens de Grenoble (ENSIEG) group led by J.C. Sabonnadiere, J.L. Coulomb and G. Meunier would bring mathematical...1985. [11] J.L. Coulomb , “Analyse tridimensionnelle des champs électriques et magnétiques par la méthode des éléments finis,” These de Doctorat...computations by the virtual work principle [10]. However Coulomb [11-13] of the ENSIEG group identified a one-step solution for the computation of

The topological pressure-temperature phase diagram and crystal structures of the dimorphic system spiperone.

PubMed

Robert, B; Perrin, M-A; Coquerel, G; Céolin, R; Rietveld, I B

2016-03-01

The topological pressure-temperature phase diagram for the dimorphism of spiperone, a potent neuroleptic drug, has been constructed using literature data and improved crystal structures obtained with new crystallographic data from single-crystal X-ray diffraction at various temperatures. It is inferred that form II, which is the more dense form and exhibits the lower melting temperature, becomes the more stable phase under pressure. Under ambient conditions, form I is more stable. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Intellectual Property Rights: Lecture Series Held in London, (United Kingdom) on 21-22 October 1991, in Brussels (Belgium) on 24-25 October 1991 and in Arlington, Virginia on 6-7 November 1991

DTIC Science & Technology

1991-01-01

des rdalitfs diverses ct niouvantes sous I’cffet croisd des 6volutions techniques et &conomIques. I en rdsulte tine...r6le est croissant. Si un tel mouvement s’observe dans nombre de pays, cla ne signifie pas qu’il leur soit commun. En effet, la confrontation des ...conceptions nationales, voire rgionales, est dIdj engagdc en raison de l’internationalisation des activitds de transfert de technologies et de

[Inherited primitive and secondary polycythemia].

PubMed

Barba, T; Boileau, J-C; Pasquet, F; Hot, A; Pavic, M

2016-07-01

Myeloproliferative disorders and secondary polycythemia cover most of the polycythemia cases encountered in daily practice. Inherited polycythemias are rare entities that have to be suspected when the classical causes of acquired polycythemia have been ruled out. Recent advances were made in the understanding of these pathologies, which are still little known to the physicians. This review reports the state of knowledge and proposes an algorithm to follow when confronted to a possible case of inherited polycythemia. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Pleural effusion: diagnosis and management].

PubMed

Pastré, J; Roussel, S; Israël Biet, D; Sanchez, O

2015-04-01

Pleural effusion management is a common clinical situation associated with numerous pulmonary, pleural or extra-pulmonary diseases. A systematic approach is needed to enable a rapid diagnosis and an appropriate treatment. Pleural fluid analysis is the first step to perform which allows a presumptive diagnosis in most cases. Otherwise, further analysis of the pleural fluid or thoracic imaging or pleural biopsy may be necessary. This review aims at highlighting the important elements of the work-up required by a pleural effusion. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Turbulence Observations in the Upper Ocean During the Surface Wave Processes Program in the Northeast Pacific, February to March 1990

DTIC Science & Technology

1992-01-01

AD-A283 895 S cientific Excellence • Resource Protection & Conservation • Benefits for Canadians Excellence scientifique • Protection et conservation...V8L 4B2 . 1992 Thi- :lci,,-nrit has been approved1 Icr P’--1iC •Lae•_se and sole; its J dIt:isbution is tuoni-ited. Canadian Data Report of...Hydrography and Ocean Sciences No. 106 94-27566 • 94 8 26 116 I I Fisheries Pdches and Oceans et Oceans Ca adc Canadian Data Report Of II’.drographý and Ocean

An Applied-Scientific Approach to Field Assessments - Try It Out - A Field Guide for Practitioners (Une approche scientifique des evaluations de terrain - Essayer le - Un guide de terrain a destination des praticiens)

DTIC Science & Technology

2017-12-01

settings – be it field trials, field experiments, tests or evaluations . This guide is based on experience of the the NATO STO Task Group (HFM-211...practice by the Task Group. Feedback from defence colleges and Training and Evaluation staffs is highly welcomed. ES - 2 STO-TR-HFM-211 Une... evaluation programs have been setup to analyse and demonstrate the added value and effectiveness of new developments such as new operational concepts, new

Management of Heat and Cold Stress -- Guidance to NATO Medical Personnel (Gestion des contraintes thermiques (chaleur et froid) Conseils aux personnels medicaux de I’OTAN)

DTIC Science & Technology

2013-12-01

de la performance de leurs troupes; b) d’importants écarts scientifiques / de capacités existent en ce qui concerne la susceptibilité, le... La HFM/RTG-187 avait pour but de : a) comparer et évaluer les ressources techniques qui sont actuellement utilisées pour un « système de gestion des ...d’une doctrine et de programmes d’enseignement intégrés pour la gestion des risques thermiques afin de garantir le maintien

Toxoplasmose oculaire atypique chez une femme congolaise de 72 ans: à propos d'une observation

PubMed Central

Bienvenu, Yogolelo Asani; Angel, Musau Nkola; Eric, Kasamba Ilunga; Socrate, Kapalu Mwangala; Sebastien, Mbuyi Musanzayi; Philippe, Cilundika Mulenga; Leon, Kabamba Ngombe; Bruno, Iye Ombamba Kayimba; Gaby, Chenge Borasisi

2015-01-01

Les auteurs rapportent un cas de toxoplasmose oculaire binoculaire, rarement décrit dans la littérature, chez une personne âgée de 72 ans, de sexe féminin, à laquelle s'associe une rétinite pigmentaire unilatérale. Cette observation permet d'attirer l'attention de la communauté scientifique sur les autres formes ou variétés de présentation moins courantes, « atypiques », pouvant être rencontrées ou associées à la toxoplasmose oculaire. PMID:26958130

Major Events Coordinated Security Solutions Technical Report Closeout (MECSS): The Application of Science and Technology to Reduce Risk for V2010 and G8/G20 Summits

DTIC Science & Technology

2010-12-01

CBRNE), aux infrastructures essentielles, à la surveillance, à la sécurité physique, à la cybernétique et à la socio- psychologie . Le présent rapport...la socio- psychologie . Dans le cadre du projet SCSGE, on a produit plus de 195 rapports scientifiques, fruit des efforts, du dévouement et du...aux infrastructures essentielles, à la surveillance, à la sécurité physique, à la cybernétique et à la socio- psychologie . Le présent rapport

Communique: Special Issue on the International Scientific Conference and Exhibit and the 7th Session of the International Co-Ordinating Council for MAB (Paris, Sept. 22-Oct. 2, 1981) = Numero special sur la Conference Scientifique Internationale et Exposition et al 7e session du Counseil International de Coordination du MAB (Paris, du 22 Sept. au 2 Oct. 1981).

ERIC Educational Resources Information Center

Communique, 1982

1982-01-01

Presented are summaries of two separate but closely-related conferences. The International Scientific Conference and Exhibit, organized to mark the 10th anniversary of the Man and the Biosphere Program (MAB), was based on the theme "ecology in practice: establishing a scientific basis for land management." This summary includes: a 10…

Communique: Special Issue on the International Network for Cooperation in Northern Science Created at a Meeting held in Edmonton, Alberta (October 12-15, 1982). Summary of Discussions and Agreements Reached = Numero special sur le Reseau Scientifique Internationale pour le Nord cree a la reunion tenue a Edmonton, Alberta (du 12 au 15 octobre 1982). Resume des discussions et accords conclus.

ERIC Educational Resources Information Center

Communique, 1983

1983-01-01

Delegations from Canada, Finland, Greenland, Norway, Sweden, and the United States agreed to the establishment of a network for cooperation among individuals engaged in problems peculiar to the circumpolar North. The Northern Science Network, established within the Unesco Man and the Biosphere Program, consists of three themes: studies on the…

Identification of complex flows in Taylor-Couette counter-rotating cavities

NASA Technical Reports Server (NTRS)

Czarny, O.; Serre, E.; Bontoux, P.; Lueptow, R. M.

2001-01-01

The transition in confined rotating flows is a topical problem with many industrial and fundamental applications. The purpose of this study is to investigate the Taylor-Couette flow in a finite-length cavity with counter-rotating walls, for two aspect ratios L=5 or L=6. Two complex regimes of wavy vortex and spirals are emphasized for the first time via direct numerical simulation, by using a three-dimensional spectral method. The spatio-temporal behavior of the solutions is analyzed and compared to the few data actually available. c2001 Academie des sciences/Editions scientifiques et medicales Elsevier SAS.

Memorial V.J.Glaser

ScienceCinema

None

2017-12-09

Plusieurs orateurs rendent hommage au grand physicien et scientifique Vladimir Jurko Glaser (1924 - 1984) qui travaillait au Ruder Boscovic Institut à Zagreb avant de venir au Cern en 1957 où il trouvait un poste permanent au département de physique théorique. Walter Tearing, Harry Lehmann,Henry Epstein, Jacques Bros et André Martin font des résumés biographiques de leurs collègue et ami en honorant ses grands qualités d'homme et ses remarquables conquêtes de la science et leurs accomplissement.

La supraconductivité a 100 ans !

ScienceCinema

Lebrun, Philippe

2018-06-12

Il y a 100 ans, le 8 avril 1911, une découverte majeure était réalisée : celle de la supraconductivité. La supraconductivité est la caractéristique qu’ont certains métaux et alliages de perdre toute résistance électrique en dessous d’une température donnée. Cette renversante découverte, réalisée de manière presque fortuite par Kammerlingh Onnes de l’Université de Leyde (Pays-Bas) et son étudiant Gilles Holst, a ouvert un nouveau champ de recherche en physique et de fabuleuses perspectives d’applications technologiques. Du point de vue scientifique, la supraconductivité est en effet l’une des rares manifestations de la physique quantique à l’échelle macroscopique.  Du point de vue des retombées techniques, elle est porteuse d’applications majeures dans le domaine de la santé, des communications et de l’énergie. 100 ans après, les physiciens n’ont toujours pas fini d’explorer ce phénomène et ses applications. Le CERN abrite des applications de la supraconductivité à des échelles inédites. L’accélérateur de particules LHC, avec ses milliers d’aimants supraconducteurs répartis sur 27 kilomètres de circonférence, est en effet la plus grande application mondiale de la supraconductivité. Il ne pourrait exister sans elle. Le CERN fête donc la découverte de la supraconductivité avec une conférence exceptionnelle donnée par Philippe Lebrun. Au cours de cette conférence, l’expérience historique de Kammerlingh Onnes sera reproduite. Philippe Lebrun racontera l’histoire de cette étonnante découverte, en la replaçant dans le contexte scientifique de l’époque. Il racontera les développements scientifiques et les applications du premier siècle de la supraconductivité. Conférence en français Merci de bien vouloir vous inscrire au : +41 22 767 76 76 ou cern.reception@cern.ch

Préface

NASA Astrophysics Data System (ADS)

Mazière, D.

2002-04-01

Faisant suite aux deux précédents colloques "Matériaux pour les machines thermiques" et "Matériaux pour le nucléaire" , le colloque 2001 de l'INSTN intitulé "Matériaux pour les énergies propres" s'est focalisé sur les problèmes de matériaux encore à résoudre dans ce secteur industriel. Le colloque de métallurgie est traditionnellement organisé par des ense ignants du DEA Métallurgie et Matériaux et un comité scientifique choisi chaq ue année en liaison avec le thème traité. Les étudiants de ce DEA, qui est hab ilité entre Paris XI, Paris VI, l'Ecole des Mines de Paris, l'Ecole Centrale de Pari s et l'INSTN, sont invités à participer à ce colloque et aux débats scientifiques qui s'y déroulent. Des conférences invitées à caractère péda gogique permettent d'introduire les différents thèmes abordés qui sont ensuite développés dans des présentations plus novatrices. Cette manifestation a pour ambition de favoriser la rencontre de scientifiques d'horizons divers venant de milieux académiques ou industriels entre eux et avec les étudiants et thésards. Cette 44e édition, dont les comptes rendus sont publiés ici, a fait le point sur les problèmes de matériaux rencontrés lors de la production, du stockage et de la conversion des énergies dites propres en englobant lesprogrès constants des industriels de l'automobile. Ce colloque a réuni, du 26 au 28 juin 2001, 63 participants provenant d'universités ou grandes écoles (18), du CEA (17), du CNRS (10) et de l'industrie ou de centres de recherche associés. L'ensemble des problèmes de matériaux de ce secteur ont été examinés au cours des six sessions ci-dessous : dépollution des gaz d'échappement ; combustion catalytique en production thermique ; nouvelles batteries ; piles à combustibles ; production et stockage d'hydrogène ; production et stockage d'énergie solaire. Vingt huit communications dont vingt deux orales ont illustré les dével oppements en cours. Dix-sept d'entre elles sont développées dans cet ouvrage. On pourra consulter avec profit le numéro 44 des Clefs CEA "Nouvelles Technologies de l'énergie" en complément du présent ouvrage.

Paternité des articles et intérêts concurrents : une analyse des recommandations aux auteurs des journaux traitant de pratique pharmaceutique

PubMed Central

Courbon, Ève; Tanguay, Cynthia; Lebel, Denis; Bussières, Jean-François

2014-01-01

RÉSUMÉ Contexte : La présence d’auteurs honorifiques et fantômes ainsi que les intérêts concurrents représentent des difficultés bien documentées, liées à la publication d’articles scientifiques. Il existe des lignes directrices encadrant la rédaction et la publication de manuscrits scientifiques, notamment celles de l’International Committee of Medical Journal Editors (ICMJE). Objectifs : L’objectif principal de cette étude descriptive et transversale visait à recenser les instructions portant sur la paternité des articles et les intérêts concurrents provenant des recommandations aux auteurs des journaux traitant de pratique pharmaceutique. L’objectif secondaire visait à déterminer des mesures correctrices pour une paternité des articles plus transparente. Méthode : La recherche a débuté par l’identification des journaux traitant de pratique pharmaceutique. La consultation des instructions aux auteurs des journaux a permis ensuite de recenser les recommandations destinées à éviter les problèmes de paternité des articles et d’intérêts concurrents. Finalement, les membres de l’équipe de recherche se sont consultés afin de définir des mesures correctrices possibles à l’intention des chercheurs. Résultats : Des 232 journaux traitant de pharmacie, 33 ont été définis comme traitant de pratique pharmaceutique. Un total de 24 (73 %) journaux mentionnaient suivre la politique de l’ICMJE, 14 (42 %) demandaient aux auteurs de remplir un formulaire de déclaration d’intérêts concurrents au moment de la soumission de l’article, 17 (52 %) présentaient une définition de la qualité d’auteur et 5 (15 %) demandaient de détailler les contributions de chaque auteur. Une grille de 40 critères a été élaborée pour définir l’attribution du statut d’auteur. Conclusion : Moins de la moitié des journaux demandait aux auteurs de transmettre un formulaire de déclaration des intérêts concurrents au moment de la soumission d’un article et seulement la moitié des journaux avait donné une définition de la qualité d’auteur. La publication scientifique de travaux sur les pratiques pharmaceutiques n’est pas à l’abri des manques de transparence liés à la publication. L’utilisation d’une grille décrivant la contribution de chaque auteur et la publication en ligne des travaux peuvent contribuer à limiter ces risques. PMID:24970938

Trends in food intake in French children from 1999 to 2007: results from the INCA (étude Individuelle Nationale des Consommations Alimentaires) dietary surveys.

PubMed

Lioret, Sandrine; Dubuisson, Carine; Dufour, Ariane; Touvier, Mathilde; Calamassi-Tran, Gloria; Maire, Bernard; Volatier, Jean-Luc; Lafay, Lionel

2010-02-01

The objectives of the present study were to assess the intake of different food groups in French children aged 3-17 years (n 1455), and to analyse trends since a dietary survey undertaken 8 years ago. Dietary intake was evaluated using data from the 2006-7 cross-sectional INCA2 national dietary survey (étude Individuelle Nationale sur les Consommations Alimentaires), based on a 7 d food record. Dietary intake (percentage of subjects consuming the food group and amount eaten) was assessed for thirty-nine food categories. We observed variations in food consumption by age, sex, North-South regional gradient, seasonal period and educational level of the responding parent. Trends in dietary intake between 1999 and 2007 were determined by comparing the INCA1 (n 1126) and the INCA2 surveys. Both surveys had been carried out using the same methodology. The findings showed a decrease in energy intake in children aged 3-14 years, due to a reduction in the consumption of foods of animal origin and sweetened products. In adolescents aged 15-17 years, energy intake remained rather stable; during this 8-year period, the consumption of meat decreased, whereas the consumption of savoury snacks such as sandwiches and hamburgers significantly increased. These trends occurred during a time of growing concern about overweight and the associated co-morbidities in France. A number of public health measures were implemented over this period to improve dietary habits and physical activity patterns in children and adults. The periodic monitoring of dietary patterns through the INCA surveys is an essential part of the surveillance network in France.

Water and beverage consumption among children aged 4-13 years in France: analyses of INCA 2 (Étude Individuelle Nationale des Consommations Alimentaires 2006-2007) data.

PubMed

Vieux, Florent; Maillot, Matthieu; Constant, Florence; Drewnowski, Adam

2016-09-01

To examine the consumption of plain water among children in France and compare total water intakes with guidelines issued by the European Food Safety Authority (EFSA). Nationally representative data were used to assess food, beverage and water consumption by sex, age group (4-8 years, 9-13 years), income-to-poverty ratio, eating occasion and location. Beverages were classified into nine groups: water (tap or bottled), milk, 100 % fruit juice, sodas, fruit drinks, hot beverages, sports drinks and flavoured waters. Total water volume in relation to energy intake (litres/kcal) was also examined. INCA 2 study (Étude Individuelle Nationale des Consommations Alimentaires 2006-2007). French children (n 835) aged 4-13 years. Total water intakes were accounted for by plain water (34 %), beverages (26 %) and food moisture (40 %). Plain water could be tap (18 %) or bottled (16 %). Older children drank more plain water than did younger children and boys drank more plain water than did girls. No socio-economic gradient for plain water consumption was observed. About 90 % of children did not meet the EFSA water intake recommendations. The daily water shortfall ranged from 367 to 594 ml/d. Water-to-energy ratio was 0·75-0·77 litres/1000 kcal (4184 kJ). Children drank milk at breakfast and plain water during lunch and dinner. Caloric beverages provided 10 % of dietary energy; consumption patterns varied by eating location. Total water intakes among young children in France were below EFSA-recommended levels. Analyses of beverage consumption patterns by eating occasion and location can help identify ways to increase water consumption among children.

Research Using In Vivo Simulation of Meta-Organizational Shared Decision Making (SDM). Task 2: Development of an Experimental Plan for In Vivo Exercise and Simulation

DTIC Science & Technology

2011-12-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC CSS CR 2011-31 ii...participants. Résumé …..... Introduction : Ce rapport présente la Tâche 2 du projet « Recherche par la simulation in-vivo sur la prise de décision partagée...environnement sur la prise de décision partagée in-vivo des opérations de gestion des urgences et pour colliger des données

Hydrogeological Investigations in Deep Wells at the Meuse/Haute Marne Underground Research Laboratory

NASA Astrophysics Data System (ADS)

Delay, Jacques; Distinguin, Marc

ANDRA (Agence Nationale pour la Gestion de Déchets Radioactifs) has developed an integrated approach to characterizing the hydrogeology of the carbonate strata that encase the Callovo-Oxfordian argillite at the Meuse/Haute-Marne Laboratory site. The argillites are difficult to characterize due to their low permeability. The barrier properties of the argillites can be inferred from the flow and chemistry properties of the encasing Oxfordian and Dogger carbonates. Andras deep hole approach uses reverse air circulation drilling, geophysical logging, flow meter logging, geochemical sampling, and analyses of the pumping responses during sampling. The data support numerical simulations that evaluate the argillites hydraulic behaviour.

New Advanced Mass Casualty Breathing System for Oxygen Therapy: Phase 1

DTIC Science & Technology

2006-10-01

of National Defence, 2006 © Sa Majesté la Reine , représentée par le ministre de la Défense nationale, 2006 DRDC Toronto TM 2006-201 i...Toronto a été chargé d’examiner la performance du masque PulmanexMD Hi-OxMD (Hi-Ox) à des débits d’oxygène (O2) de 4 litres par minute (L·min-1) en...d’examiner la performance du masque PulmanexMD Hi-OxMD (Hi-Ox) à des débits d’oxygène (O2) de 4 litres par minute (L·min-1). Le masque Hi-Ox est un

List of Standards to Accompany Manual of Documentation Practices Applicable to Defence-Aerospace Scientific and Technical Information (Liste des Normes a Placer en Annexe au Manuel Concernant les Techniques Documentaires Applicables a l’Information Scientifique et Technique de la Defense et du Secteur Aerospatial)

DTIC Science & Technology

1990-10-01

CHARACTERS ISO 0233 1984 DOCUMENTATION - TRANSLITERATION OF ARABIC CHARACTERS INTO LATIN CHARACTERS ISO 0259 1954 DOCUMENTATION - TRANSLITERATION OF HEBREW...TRANSLITERATION OF ARABIC CHARACTERS IN LATIN CHARACTERS SF I 46-DUO 1N64 TRANSLITERATION - TRANSLITERATION OF HEBREW IN LATIN CHARACTERS . 46-010...LANGUAGE CODES (ANNIE: AUT.ORITY SYMSOLS DIN 31 634 CONVERSION OF THE GREEN ALUBABET DIN 31 635 CONVERSION OF THE ARABIC ALPHABET DIN 31 635 CONVERSION OF

What would researchers like to improve in communication initiatives?

NASA Astrophysics Data System (ADS)

Russo, Pedro

2015-08-01

One of the most important current trends in astronomy communication has been “change”. The field of astronomy communication has rapidly evolved in just the past few years, as new techniques and technologies have been adopted. Research astronomy has also visibly changed, as automation of survey systems and the launch of new telescopes has produced a tsunami of big data sets. Today, scientists and communicators must work together to navigate the raging waters of this data flood as they strive to keep our tech-savvy society informed. This invited talk will be given by Alain Doressoundiram (Observatoire de Paris, Centre National de la Recherche Scientifique, France) TBC

Conference Proceedings of International High Speed Networks for Scientific and Technical Information, Held at Ottawa, Canada on 6-7 October 1993 (Les Reseaux Internationaux Rapides D’Echange D’Information Scientifique et Technique)

DTIC Science & Technology

1994-02-01

examined issues, such asstandards, security, management , property rihts/copyright, etc., ftom the pint of view of the end user, the information provider...de lIST sur l’afrospatiale, Is difense et sur d’autres domaines. Toutefois, l’imergence de ces r6scaux laisse poindre certaines preoccupations et...questions. Cette riunion de spdcialistes des pays de I’OTAN a permis de faire It survol de Ia situation, d’evaluer le potentiel d’avenir et d’examiner

Seminar Andrej Sacharov

ScienceCinema

None

2017-12-09

A l'occasion de son 63me anniversaire 2 orateurs rendent hommage à A.Sacharov, physicien russe et né à Moscou, pour ses accomplissements scientifiques et son courage. A.Sacharov a dénoncé les dangers de la radioactivité et a tenté de persuader les autorités soviétiques de supprimer une série de test après le developpement de la bombe atomique en 1949 et la bombe à hydrogène en 1953 par un groupe de chercheurs soviétiques. Il a obtenu le prix Nobel en 1975.

Investigation into the Combined Effects of Compaction, Strain Rate Sensitivity, and Anisotropic Damage of a Geologic Target on the Trajectory Stability of Rigid Penetrators

DTIC Science & Technology

2007-05-01

32579, E-mail: cazacu@reef.ufl.edu 2 Laboratoire de Math~matiques, Universit6 de Savoie, Campus Scientifique, 73376 Le Bourget-du-Lac Cedex, France E...1971) is that at rest the granular material obeys a Coulomb yield condition. Once the flow develops the state of stress is a function of the rate of...then a (d,e,p) = P(d,e,p), /3(d,e,p) = -Q( de ,p) (19) V3 c Next, these expressions for a and 3 are substituted in the compatibility restrictions (5

Effet des Plastifiants sur la Temperature de Transition Vitreuse, Tg, du Butadiene a Terminaison Hydroxy et du Polyazoture de Glycidyle - Simulations et Experiences (Effect of the Plasticizers on the Vitreous Transition Temperature, Tg, of the Butadiene to Termination Hydroxy and the Polyazoture of Glycidyle - Simulations and Experiences)

DTIC Science & Technology

2008-09-01

diverses temperatures 26 a) HTPB pur b) HTPB-DOA (polymere et plastifiant) c) GAP pur d) Gpl pur e)Gap-Gpl Liste des tableaux Tableau 1...Composition des mailles amorphes construites 11 Tableau 2. Proprietes des polymeres et plastifiants utilises 11 Tableau 3. Comparaisons entre les Tt...obtenues experimentalement, les T% publiees dans les ecrits scientifiques et celles predites a partir des 7"gdes composes purs 19 Tableau 4. Comparaison

Les bons conseils de la naissance à la maternelle

PubMed Central

Rourke, Leslie; Leduc, Denis; Constantin, Evelyn; Carsley, Sarah; Rourke, James; Li, Patricia

2013-01-01

Résumé Objectif Donner un aperçu de la version 2011 du Relevé postnatal Rourke (RPR), qui comporte aussi des nouveautés dans son site web et de nouvelles initiatives connexes et qui intègre les données des ouvrages scientifiques récents sur les soins de santé préventifs à l’intention des enfants de 0 à 5 ans. Qualité des données À l’instar des versions antérieures du RPR, la nouvelle édition présente des recommandations identifiées comme se fondant sur des preuves suffisantes, acceptables ou consensuelles, selon les classifications adoptées par le Groupe d’étude canadien sur les soins de santé préventifs en 2011. Message principal De nouveaux renseignements et des recommandations sont présentés concernant la surveillance de la croissance, la nutrition et la vaccination contre la varicelle, les pneumocoques, les méningocoques et le rotavirus. Il y a maintenant de bonnes données probantes en faveur de l’adaptation canadienne des courbes de croissance de l’Organisation mondiale de la Santé, du dépistage universel des problèmes d’audition chez le nouveau-né et du recours à des stratégies de réduction de la douleur liée à la vaccination. On a mis à jour les conseils anticipatoires concernant la sécurité durant le sommeil, la supervision de la santé des enfants en foyer d’accueil, le trouble du spectre de l’alcoolisation fœtale, les facteurs de risque nécessitant le dépistage du plomb et de l’anémie, les soins dentaires et la santé buccale. Parmi les nouvelles rubriques dans le site web du RPR, on peut mentionner une section présentant des ressources pour les parents, des modifications à l’intention de populations particulières, comme les personnes vivant au Nunavut, une version du RPR qui met en évidence en un coup d’œil les modifications à la version de 2009 et une expansion de la fonction d’exploration du RPR accompagnée des hyperliens connexes menant aux renseignements pertinents. On peut aussi avoir accès au RPR sous forme d’une page par visite. Le Collège des médecins de famille du Canada et la Société canadienne de pédiatrie ont donné leur aval au RPR de 2011. Les versions nationale et ontarienne sont disponibles en français et en anglais. Conclusion Le RPR de 2011 est un outil pratique, mis à jour, fondé sur des données probantes de transposition du savoir concernant les soins de santé préventifs aux enfants de la naissance à l’âge de 5 ans. Il propose des ressources exhaustives dans le web à l’intention des professionnels de la santé, des étudiants, des résidents et des parents.

Profil de la néphropathie diabétique à l’Hôpital Général de Référence Nationale de N'Djamena (Tchad)

PubMed Central

Hamat, Ibrahim; Abderraman, Guillaume Mahamat; Cisse, Mouhamadou Moustapha; Youssouf, Mahamat; Djafar, Matar Saboune; Mbainguinam, Dionadji; Fotclossou, Tara

2016-01-01

Introduction Le diabète sucré constitue un véritable problème de santé et ses complications touchent plusieurs organes dont les reins. Un diagnostic précoce de la néphropathie diabétique permet de prendre en charge les patients plus efficacement et de façon multidisciplinaire, de retarder sa progression vers l'insuffisance rénale chronique. Peu d'études ont été faites en Afrique dans ce domaine. Au Tchad, nous ne disposons pas de données statistiques sur l'atteinte rénale liée au diabète. C'est pourquoi nous nous proposons d'étudier la néphropathie diabétique avec pour objectifs d'analyser le profil de la néphropathie diabétique des patients de l'hôpital général de référence nationale de N'Djamena. Méthodes Nous avions mené une étude transversale descriptive à l'Hôpital Générale de Référence Nationale de N'Djamena d'avril à septembre 2012. Etaient inclus dans l'étude tous les patients diabétiques hospitalisés ou suivis dans les services de néphrologie et d'endocrinologie. Résultats Il y avait 54 cas de néphropathie diabétique sur 181 patients soit 29,80%. L'âge de plus de 50 ans représentait 87%, le sexe masculin dominait avec 67%, la durée d'évolution du diabète au moment de la découverte de la néphropathie était de 10,25 ans, la pression artérielle moyenne était de 138 mm Hg, l'HbA1C était supérieur à 6,5% dans 74,5%, l'insuffisance rénale terminale était retrouvée dans 26,90%, une protéinurie à 2,65 g/24 h était détectée dans 60,30%. 57,4% des patients avaient une rétinopathie diabétique au stade III. Conclusion Au Tchad, la fréquence de la néphropathie diabétique est de l'ordre de 29,83%. C'est une affection qui touche les hommes avec une moyenne d'âge de 58,7 ans. Le diabète de type 2 est le plus fréquent avec 90,7% des cas. Les facteurs de risque mal contrôlés pouvaient conduire la néphropathie diabétique vers une altération de la fonction rénale notamment l'HTA (70,8%), un déséquilibre glycémique (66,7%) et une protéinurie (62,5%). PMID:27795790

Effects of Integrated Hearing Protection Headsets on the Quality of Radio Communications (Effets des Casques D’ecoute Munis d’un Dispositif Integre de Protection de L’Ouie sur la Qualite des Communications Radio)

DTIC Science & Technology

2009-07-01

National Defence, 2009 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2009 DRDC Toronto TR...Parallèlement, on a évalué le degré d’acceptation de l’utilisateur à l’aide d’un questionnaire. Méthode: Cinq hommes ayant un seuil d’audition...hearing protection and usability. Résumé …..... L’intelligibilité de la parole en provenance d’un poste radio personnel (PRR) muni de casques

Final closure of a low level waste disposal facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Potier, J.M.

1995-12-31

The low-level radioactive waste disposal facility operated by the Agence Nationale pour la Gestion des Dechets Radioactifs near La Hague, France was opened in 1969 and is scheduled for final closure in 1996. The last waste package was received in June 1994. The total volume of disposed waste is approximately 525,000 m{sup 3}. The site closure consists of covering the disposal structures with a multi-layer impervious cap system to prevent rainwater from infiltrating the waste isolation system. A monitoring system has been set up to verify the compliance of infiltration rates with hydraulic performance objectives (less than 10 liters permore » square meter and per year).« less

The topological phase diagram of cimetidine: A case of overall monotropy.

PubMed

Céolin, R; Rietveld, I B

2017-03-01

Cimetidine is a histamine H 2 -receptor antagonist used against peptic ulcers. It is known to exhibit crystalline polymorphism. Forms A and D melt within 0.35 degrees from each other and the enthalpies of fusion are similar as well. The present paper demonstrates how to construct a pressure-temperature phase diagram with only calorimetric and volumetric data available. The phase diagram provides the stability domains and the phase equilibria for the phases A, D, the liquid and the vapor. Cimetidine is overall monotropic with form D the only stable solid phase. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Les nanostructures pour créer de la couleur, un art inspiré par la nature

NASA Astrophysics Data System (ADS)

Ball, Philip

2018-02-01

Les reflets changeants des plumes de la queue du paon ont captivé plus d'un esprit curieux. Le scientifique anglais Robert Hooke les qualifiait en 1665 de « surnaturelles » en constatant que, mouillées, elles perdaient leurs couleurs. À l'aide du microscope inventé depuis peu, il observa ces plumes, et découvrit qu'elles étaient couvertes de stries - qu'il suspecta d'être à l'origine des couleurs. Aujourd'hui, la recherche tente de s'inspirer de ces phénomènes : des applications « bio-inspirées » sont en voie de concrétisation. ARRAY(0x29ad218)

A model for the construction of elementary concepts

NASA Astrophysics Data System (ADS)

von Glasersfeld, Ernst

1999-03-01

In his paper Les épistémologies constructivistes: Un nouveau commencement (Sciences de la Société, n°40, 1997), Jean-Louis Le Moigne poses the question: "Le rêve d'une connaissance autoréférentielle se fondant sur elle-même, est sans doute fascinant … Mais est-il scientifiquement raisonnable?". Building on the work of Jean Piaget, I shall try to show through a developmental analysis of elementary, scientifically relevant concepts, such as `change', `object permanence', `space', and `time', that the notion of the thinking subject's construction of knowledge constitutes a more reasonable foundation for science than the traditional belief in the representation of objective reality.

“French Phage Network”—Third Meeting Report

PubMed Central

Gandon, Sylvain; Petit, Marie-Agnès; Tavares, Paulo; Boulanger, Pascale

2018-01-01

In its third year of existence, the French Phage Network (Phages.fr) is pursuing its expansion. With more than 25 groups, mostly based in France, working on the various aspects of phage research, the network has increased its visibility, interactivity, and activity. The third meeting of the Phages.fr network, held on November 2017 at the Gif-sur-Yvette Centre National de la Recherche Scientifique (CNRS) campus, was a great opportunity for many young scientists to present their work and interact with more senior scientists, amongst which several were invited from abroad. Here we provide a summary of the work presented at this occasion during the oral presentations and poster sessions. PMID:29534436

Psychiatric and substance use disorders in HIV/hepatitis C virus (HCV)-coinfected patients: does HCV clearance matter? [Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) HEPAVIH CO13 cohort].

PubMed

Michel, L; Lions, C; Winnock, M; Lang, J-P; Loko, M-A; Rosenthal, E; Marchou, B; Valantin, M-A; Morlat, P; Roux, P; Sogni, P; Spire, B; Poizot-Martin, I; Lacombe, K; Lascoux-Combe, C; Duvivier, C; Neau, D; Dabis, F; Salmon-Ceron, D; Carrieri, M P

2016-11-01

The objective of this nested study was to assess the prevalence of psychiatric disorders in a sample of HIV/hepatitis C virus (HCV)-coinfected patients according to their HCV status. The nested cross-sectional study, untitled HEPAVIH-Psy survey, was performed in a subset of HIV/HCV-coinfected patients enrolled in the French Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) CO13 HEPAVIH cohort. Psychiatric disorders were screened for using the Mini International Neuropsychiatric Interview (MINI 5.0.0). Among the 286 patients enrolled in the study, 68 (24%) had never received HCV treatment, 87 (30%) were treatment nonresponders, 44 (15%) were currently being treated and 87 (30%) had a sustained virological response (SVR). Of the 286 patients enrolled, 121 patients (42%) screened positive for a psychiatric disorder other than suicidality and alcohol/drug abuse/dependence, 40 (14%) screened positive for alcohol abuse/dependence, 50 (18%) screened positive for drug abuse/dependence, 50 (17.5%) were receiving an antidepressant treatment and 69 (24%) were receiving an anxiolytic. Patients with an SVR did not significantly differ from the other groups in terms of psychiatric disorders. Patients receiving HCV treatment screened positive less often for an anxiety disorder. The highest rate of drug dependence/abuse was among HCV treatment-naïve patients. Psychiatric disorders were frequent in HIV/HCV-coinfected patients and their rates were comparable between groups, even for patients achieving an SVR. Our results emphasize the need for continuous assessment and care of coinfected patients, even after HCV clearance. Drug addiction remains an obstacle to access to HCV treatment. Despite the recent advent and continued development of directly acting antiviral agents (DAAs), it is still crucial to offer screening and comprehensive care for psychiatric and addictive disorders. © 2016 British HIV Association.

Morocco, Kingdom of the young geologist!

NASA Astrophysics Data System (ADS)

Bouttemy, Franck

2015-04-01

The Kingdom of Morocco is a country of 33 million people where about thirty French schools enroll 32,000 students including a majority of Moroccans. The Rabat Center includes several institutions enrolling 5,700 students aged 10 to 18 years old whose High School René Descartes is directed by the A.E.F.E, "Agency for French Teaching Abroad". Sixteen professors teach S.V.T. "Sciences de la Vie et de la Terre" that focuses on biology and geology. The programs involved are French but the biology-geology colleagues seek to place the teaching of geology in the context of Morocco through the choice of Moroccan examples. (https://sites.google.com/site/aefesvtmaroc/) Morocco's geology lends itself to this approach! The laboratory is equipped with a seismometer in the network "Sismos to School" (https://sites.google.com/a/lycee-descartes.ma/rabt_sismo/home) and we have the equipment necessary for making thin sections of the Moroccan rocks for practical work on a polarizing microscope. We organize several field trips: On a half-day in the region of Rabat, 12-year old pupils of "5ème", learn about reading the landscape and studying sedimentary rocks such as marls and sandstones. On a 3-day excursion in the region of Azrou, the16-year old pupils of "première scientifique" study the tectonic context of formation of mineral resources. A 2-day trip in the region of Oulmès, the17-year old pupils of "terminale scientifique" (the last year in the French system finishing with the "baccalaureate") study continental crust, tectonics and geothermal energy. These field trips will be presented in this poster. Students make field studies: observation, testing, photography, drawing and taking notes. Some works are evaluated during the field trip, others are the subject of home work: preparing a slide show, an audio recording work...

Effets potentiels d’un modèle rationnel de prescription sur les dépenses nationales en santé

PubMed Central

Littman, Jordan; Halil, Roland

2016-01-01

Résumé Objectif Estimer les économies que pourrait engendrer la mise en œuvre d’un modèle rationnel de prescription pour des classes de médicaments équivalents sur les plans de l’efficacité, de la toxicité et de la commodité. Conception L’Institut canadien d’information sur la santé a fourni des renseignements sur les 10 principales classes de médicaments en fonction des dépenses annuelles qui leur sont attribuables. Ces classes ont été examinées en vue de leur inclusion potentielle dans l’étude selon qu’il était possible de comparer les médicaments à l’intérieur d’une même classe. Lorsqu’à la suite d’une recherche documentaire, une équivalence a été établie en fonction de l’efficacité, de la toxicité et de la commodité des médicaments, les données annuelles sur les prescriptions ont été recueillies à partir de la base de données du Système national d’information sur l’utilisation des médicaments prescrits. Les économies potentielles de coûts ont ensuite été calculées en comparant les parts de marché actuelles avec les parts potentielles futures de ce marché. Contexte Le Canada. Principaux paramètres à l’étude Les différences estimées dans les dépenses que produirait un modèle rationnel de prescription. Résultats Une équivalence a été établie sur les plans de l’efficacité, de la toxicité et de la commodité dans les classes de statines, d’inhibiteurs de la pompe à protons, d’inhibiteurs de l’enzyme de conversion de l’angiotensine et d’inhibiteurs sélectifs du recaptage de l’angiotensine. Les dépenses annuelles totales dans ces classes se situent à 856 millions $ dans les programmes publics de médicaments et à 1,97 milliard $ environ à l’échelle nationale. Grâce à des prescriptions rationnelles, on estime que les économies annuelles pourraient atteindre 222 millions $ pour les programmes publics et 521 millions $ à l’échelle nationale. Conclusion La majorité des économies potentielles seraient attribuables à l’abandon des médicaments les plus récents protégés par un brevet dans chaque classe. En évitant de prescrire les plus récents médicaments intraclasses, en particulier en l’absence de recherche établissant leur supériorité dans les résultats cliniques pertinents, on pourrait réaliser des économies considérables dans les dépenses en santé et inciter l’industrie pharmaceutique à innover plutôt qu’à imiter.

Engaging High School Students and Scientists in a Café Scientifique Program

NASA Astrophysics Data System (ADS)

Mayhew, M. A.; Hall, M. K.; Foutz, S.

2010-12-01

We have created an informal science program that engages high school age youth in exploring science relevant to their lives with researchers working at the cutting edge of science. The program provides scientists a challenging new audience to share their research and enthusiasm for science and science careers. It gives the youth an opportunity to discover how the often-mundane science they are learning in school is used to push the frontiers in science, with exciting applications in the real world. Our program, a youth-led Café Scientifique (cafenm.org), now in its fourth year, has been successful in attracting and retaining youth as well as attracting scientist-presenters. Modeled after the international Café Scientifique program for adults, we combine a social atmosphere with discussion of controversial or current topics to challenge youth to think about how science affects their lives. We feature short presentations with a high degree of interactivity and discussion during which the scientist expert communicates a single important idea or scientific principle. A good speaker will leave the audience with a dilemma or controversy to discuss, and with further opportunities to learn. Encouraging the presenters to interact frequently with the audience allows them to gauge the audience's engagement and knowledge. Alternatively we also host Cafés that offer more hands-on learning experiences, including extracting DNA from plants, building model fuel cell cars, using Google Earth to spy, and deciphering age, gender, ethnicity, and cause of death from human skeletons. Controversial topics are often presented within a scientific, economic, and social or political framework, because science is only part of the solution. A key element of success is in preparing the presenters for the youth audience. Presenters submit their presentation to the program directors for initial review and receive feedback on length, mechanisms for involving the audience, and clarifying or removing extraneous details in their slides. They then give a practice talk to a small group of youth prior to presenting to the full audience to ensure they are reaching the target audience. Speakers, in retrospect, frequently indicate the dry run with the youth relieved much of their anxiety about reaching out to youth. One of the most important keys to the success of the program to date is that to the greatest extent possible we have allowed the youth to embrace the Café program as their program. An important aspect of this is the Youth Leadership Teams that were formed in each town. The youth leaders run all aspects of the Café meetings (with adults in the background providing support as needed), advise on what topics should be presented, and take on responsibility for promoting the program in their respective communities. Evaluation studies indicate the youth are learning new science concepts, broadening their understanding of what scientists do, and more frequently see how science touches their lives. There is also evidence that substantive learning of STEM content and changes in attitudes about science, scientists, and science careers occurs.

[Evolutionary medicine: A new look on health and disease].

PubMed

Bauduer, F

2017-03-01

Evolutionary medicine represents an innovative approach deriving from evolutionary biology. It includes the initial Darwin's view, its actualization in the light of progresses in genetics and also dissident theories (i.e. non gene-based) particularly epigenetics. This approach enables us to reconsider the pathophysiology of numerous diseases, as for instance, infection, and our so-called diseases of civilization especially obesity, type 2 diabetes, allergy or cancer. Evolutionary medicine may also improve our knowledge regarding inter-individual variation in susceptibility to disease or drugs. Furthermore, it points out the impact of our behaviors and environment on the genesis of a series of diseases. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Hereditary angioedema: a therapeutic revolution].

PubMed

Bouillet, L

2012-03-01

Hereditary angioedema is a rare disease, often diagnosed with delay because of a heterogeneous clinical presentation. Before diagnosis, patients frequently present subcutaneous edema or abdominal pains during many years. Laryngeal edema can be life-threatening. Hereditary angioedema may impair the quality of life of the patients and their social and professional life. It is important that the physicians recognize and treat the disease as soon as possible after the first attacks. Since the past five years, new drugs developed for hereditary angioedema have changed dramatically the outcome of this disorder. The objective of this review is to detail the new therapeutic guidelines. Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Antineutrophil cytoplasmic antibodies associated with infective endocarditis: Literature review].

PubMed

Langlois, V; Marie, I

2017-07-01

Antineutrophil cytoplasmic antibodies (ANCA) associated with infective endocarditis are a rare disorder. The condition can mimic primary systemic vasculitis (i.e. granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis). Thus, a wrong diagnosis of valvular involvement related to primary systemic vasculitis can be made in patients exhibiting ANCA associated with infective endocarditis. Because treatment of both conditions is different, this wrong diagnosis will lead to dramatic consequences in these latter patients. This review reports the state of knowledge and proposes an algorithm to follow when confronted to a possible case of ANCA associated with infective endocarditis. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Synthesis, antioxidant and analgesic activities of Schiff bases of 4-amino-1,2,4-triazole derivatives containing a pyrazole moiety.

PubMed

Karrouchi, K; Chemlal, L; Taoufik, J; Cherrah, Y; Radi, S; El Abbes Faouzi, M; Ansar, M

2016-11-01

A series of Schiff bases of 4-amino-1,2,4-triazole derivatives containing pyrazole (5a-h) were synthesized from condensation of 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1,2,4-triazole-3-thiol (3) derivative with various aromatic aldehydes (4a-h). The structures of the synthesized compounds were elucidated by IR, 1 H NMR, 13 C NMR, and mass spectrometry. All the synthesized compounds (5a-h) were screened for their in vivo analgesic and in vitro antioxidant activities revealing significant analgesic and antioxidant properties. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[The plague: A disease that is still haunting our collective memory].

PubMed

Peiffer-Smadja, N; Thomas, M

2017-06-01

Although the plague has practically disappeared from Europe since the beginning of the 20th century, it is still present in everyone's memory. Owing to three pandemics, it has left an indelible mark on mankind and has given rise to many popular phrases, paintings, books or more recently movies and video games. After a brief description of the plague as a disease, we will try to trace the history of the plague through some of the works of art it inspired and then to show how the plague is still haunting our collective memory. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Primary infection with cytomegalovirus: An infectious cause of splenic infarction].

PubMed

Kassem, H; Khamadi, K; Farrugia, C; Ho Hio Hen, N; El Gharbi, T; Turner, L

2017-08-01

Cytomegalovirus-associated thrombosis has been extensively reported in the medical literature, mainly in immune-compromised patients. However, the association with splenic infarcts has rarely been reported. We report a 32-year-old Caucasian and immunocompetent woman who presented with a splenic infarction during a primary infection with CMV. The differential diagnostic ruled out embolic, hematologic, gastrointestinal and coagulation disorders. The outcome was favorable with symptomatic treatment. A primary infection with CMV must be added to the diagnostic work-up in the presence of a febrile splenic infarction, especially when it is associated with a biological mononucleosis reaction. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

The career paths of women (and men) in French research.

PubMed

de Cheveigné, Suzanne

2009-02-01

This paper presents results from a qualitative study of perceptions of science careers in the Centre National de la Recherche Scientifique (CNRS), the main research institution in France. Its aim is to understand the 'glass ceiling' effect, which reduces the proportion of women at the higher levels of the career hierarchy. Long interviews were carried out with men, as well as women, support staff and researchers. Factors such as tension between individual and collective dimensions of research activity, and long-term time-management problems, were identified: these affect both men and women but in different ways. Organizations bear an important responsibility through the way they reinforce or alleviate difficulties that women and men face in contributing to scientific research at all levels.

[The French medecine pricing committee and the medicine economic policy: Rules and competences].

PubMed

Giorgi, D

2017-09-01

The French medicine pricing committee (CEPS), a governmental and inter-institutional body exercises essential competences for the regulation of the economy of the reimbursable drugs in France. It provides a good example of administered price regulation. It also supervises the proper use of products (control of promotion, conventional control of sales volumes). Finally, it regulates the annual envelope of drug expenditures by means of discounts paid by pharmaceutical companies. The article presents the legal criteria and the doctrine of price setting used in France. It details the types of market access contracts concluded by the CEPS. It specifies the conditions governing the annual envelope of expenditures on reimbursable medicines. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Hydroxychloroquine-induced hearing loss: First case of positive rechallenge and analysis of the French pharmacovigilance database].

PubMed

Chatelet, J-N; Auffret, M; Combret, S; Bondon-Guitton, E; Lambert, M; Gautier, S

2017-05-01

Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus. Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

From dipolar to multipolar interactions between ultracold Feshbach molecules

NASA Astrophysics Data System (ADS)

Quéméner, Goulven; Lepers, Maxence; Luc-Koenig, Eliane; Dulieu, Olivier

2016-05-01

Using the multipolar expansion of electrostatic and magnetostatic potential energies, we characterize the long-range interactions between two weakly-bound diatomic molecules, taking as an example the paramagnetic Er2 Feshbach molecules which were produced recently. The interaction between atomic magnetic dipoles gives rise to the usual R-3 leading term of the multipolar expansion, where R is the intermolecular distance. We show that additional terms scaling as R-5, R-7 and so on also appear, which are strongly anisotropic with respect to the orientation of the molecules. These terms can be seen as effective molecular multipole moments reflecting the spatial extension of the molecules which is non-negligible compared to R. We acknowledge the financial support of the COPOMOL project (ANR-13-IS04-0004) from Agence Nationale de la Recherche.

[Amyloidosis: Up-to-date].

PubMed

Magy-Bertrand, N

2016-08-01

Amyloidosis is mainly a systemic disease belonging to protein-folding diseases. The past 10 years have shown significant progress in typing and the clinical management of amyloidosis, in the identification of novel prognostic markers for risk-stratification, and also in the development of new therapeutic agents. Biological molecular techniques are now able to type amyloidosis which were unidentified. Cardiac MRI and biomarkers allow a precise risk-stratification, especially in AL amyloidosis. If necessary, this prognostic evaluation may lead to rapid changes in the chemotherapy treatment. Emerging treatments rely on biotherapies, gene therapy, immunotherapy and blocking analogous agents. They give hope about an increase of survival of patients with systemic amyloidosis. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Postural tachycardia syndrome (PoTS): An up-to-date].

PubMed

Astudillo, L; Laure, A; Fabry, V; Pugnet, G; Maury, P; Labrunée, M; Sailler, L; Pavy-Le Traon, A

2018-06-13

Postural tachycardia syndrome (PoTS) is a multifactorial syndrome defined by an increase in heart rate ≥30bpm, within 10minutes of standing (or during a head up tilt test to at least 60°), in absence of orthostatic hypotension. It is associated with symptoms of cerebral hypoperfusion that are worse when upright and improve in supine position. Patients have an intense fatigue with a high incidence on quality of life. This syndrome can be explained by many pathophysiological mechanisms. It can be associated with Ehlers-Danlos disease and some autoimmune disorders. The treatment is based on nonpharmacological measures and treatment with propranolol, fludrocortisone or midodrine. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Organizational Strategies for Critical Transportation Infrastructure: Characteristics of Urban Resilience. The Case of Montreal.

NASA Astrophysics Data System (ADS)

Beauregard, Stéphane; Therrien, Marie-Christine; Normandin, Julie-Maude

2010-05-01

Organizational Strategies for Critical Transportation Infrastructure: Characteristics of Urban Resilience. The Case of Montreal. Stéphane Beauregard M.Sc. Candidate École nationale d'administration publique Julie-Maude Normandin Ph.D. Candidate École nationale d'administration publique Marie-Christine Therrien Professor École nationale d'administration publique The proposed paper presents preliminary results on the resilience of organizations managing critical infrastructure in the Metropolitan Montreal area (Canada). A resilient city is characterized by a network of infrastructures and individuals capable of maintaining their activities in spite of a disturbance (Godschalk, 2002). Critical infrastructures provide essential services for the functioning of society. In a crisis situation, the interruption or a decrease in performance of critical infrastructures could have important impacts on the population. They are also vulnerable to accidents and cascading effects because on their complexity and tight interdependence (Perrow, 1984). For these reasons, protection and security of the essential assets and networks are one of the objectives of organizations and governments. But prevention and recovery are two endpoints of a continuum which include also intermediate concerns: ensuring organizational robustness or failing with elegance rather than catastrophically. This continuum also includes organizational resilience (or system), or the ability to recover quickly after an interruption has occurred. Wildavsky (1988) proposes that anticipation strategies work better against known problems while resilience strategies focus on unknown problems. Anticipation policies can unnecessarily immobilize investments against risks, while resilience strategies include the potential for a certain sacrifice in the interests of a more long-term survival and adaptation to changing threats. In addition, a too large confidence in anticipation strategies can bring loss of capacity of an organization to adapt to conditions. Each strategy must adapt to specific conditions. Where uncertainties important, resilience is probably the most appropriate. Where conditions are stable, and where future projections are generally fair, anticipating works better, although it should be used judiciously (Fiksel, 2003). Anticipation strategies immobilize specific or tangible resources and, can eventually be costly in the long-term. On the other hand, resilient systems and organizations are those that quickly acquire information about their environments, quickly change their behaviour and their structures, even if the circumstances are chaotic. They communicate easily and openly, and largely mobilize networks of expertise and support (Perrow, 1999). We conducted qualitative research to assess different variables that positively affect the organizational resilience in the management of critical infrastructure. We preferred a methodology allowing us to retain the complexity of the phenomenon, not affecting the nature of the system studied. Our methodology allows us to create pragmatic theoretical concepts (grounded theory) (Glaser and Strauss, 1967). Our main concern is not to separate the phenomenon studied in its context. This methodology allows us to better understand the coordination between the organizations network infrastructure essential by a process of "sweeping-in" (Dewey, 1938). After conducting a literature review of various concepts of our research (Comfort, L. K., 2002; Lagadec and Michel-Kerjan, 2004; Perrow, 1999; Weick and Sutcliffe, 2001; and more) we have conducted numerous interviews and distributed a questionnaire to highlight significant indicators. For the first part of this research, we targeted the transportation critical infrastructure of Montreal area because it is crucial and also this infrastructure includes public, parapublic and private organisations. The first results of this research demonstrate the contribution of different structural and functional factors that influence the intraorganizational resilience and interorganizational resilience for the transportation sector of Montreal.

25th Birthday Cern- Restaurant

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-05-05

Cérémonie du 25ème anniversaire du Cern avec plusieurs orateurs et la présence de nombreux autorités cantonales et communales genevoises et personnalités, directeurs généraux, ministres, chercheurs.... Le conseiller féderal et chef du département des affaires étrangères de la confédération Monsieur Pierre Aubert prend la parole pour célébrer à la fois les résultats très remarquables de la coopération internationale en matière scientifique, mais aussi la volonté politique des états européens de mettre en commun leurs ressources pour faire oeuvre d'avenir. Un grand hommage est aussi donné aux deux directeurs disparus, les prof.Bakker et Gregory.

Making Time for Spacetime: The Story of a National Science Cafe Effort

NASA Astrophysics Data System (ADS)

Redmond, Kendra; Chakrabarti, Anish

2012-03-01

Science Cafes are live and lively events that take place in casual settings such as coffeehouses or bars, are open to everyone, and feature an engaging conversation with a scientist about a compelling scientific topic. The Science Cafe movement in the United States is a grassroots effort to really engage the public in discussions about science and its relevance to society, inspired by the United Kingdom Cafe Scientifique organization. With support from NOVA and the related website sciencecafes.org, a number of Society of Physics Students chapters hosted local Cosmic Cafes (cosmic themed science cafes) in late 2011 and early 2012. This presentation will discuss the goals and models of the Science Cafe movement, the Cosmic Cafe effort, lessons learned, and how you can get involved.

Challenges to reestablishment of free-ranging populations of black-footed ferrets

USGS Publications Warehouse

Biggins, D.E.; Godbey, J.L.

2003-01-01

The black-footed ferret (Mustela nigripes) of North America is critically endangered due in part to its extreme specialization on formerly stable and abundant prairie dogs (Cynomys). Its close relative, the Siberian polecat (M. eversmannii) seems to have been subjected to a varying environment that was not conducive to specialization. One source of environmental variation in Asian steppes was plague (caused by Yersina pestis), which was absent from North America. Introduction of plague to North America presents serious challenges to ferret recovery. Partial solutions to other biological and political problems have been found, resulting in improved production in captivity, increased survival post-release, and thriving populations in plague-free South Dakota. ?? 2003 Acade??mie des sciences. Published by E??ditions scientifiques et me??dicales Elsevier SAS. All rights reserved.

A Cafe Scientifique for Teens

NASA Astrophysics Data System (ADS)

Hall, M.; Mayhew, M.

2008-12-01

It is well-known to those pursuing the quest to connect scientists to the public that an exceedingly hard-to- reach demographic is people of high school age. Typically, kids may tag along with their parents to museums until they reach adolescence, and then don't again appear in museums until they themselves have children. We have addressed this demographic challenge for free-choice-learning by developing a Cafe Scientifique program specifically for high school students. The Cafe Scientifique model for adults was developed in England and France, and has now spread like wildfire across the U.S. Typically, people come to a informal setting like a cafe, socialize and have food and drink, and then hear a short presentation by a scientist on a hot science topic in the news. This is followed by a period of lively discussion. We have followed this model for high school age students in four towns in northern New Mexico--Los Alamos, Santa Fe, Espanola, and Albuquerque--which represent a highly diverse demographic. We started this novel project with some trepidation, i.e. what if we build it and they don't come. But the program has proven popular beyond our expectations in all four towns. A part of the secret of success is the social setting, and-especially for this age group-the food provided. But we have also found that the kids are genuinely interested in the science topics, directing their own program, and interacting with scientists. We have often heard statements like, "I think it is important to be well-informed citizens". One of the most important aspects of the Cafes for the kids is to be able to discuss and argue about issues related to the science topic with the presenter and each other. It is an important part of the popularity that the Cafes do not involve school or parents, but also that we have strived to give the kids ownership of the program. Each town has a Youth Leadership Team-open to any teen-that discusses and prioritizes potential topics, conducts campaigns to advertise and draw other kids to the Cafes, and runs the meetings, while the adults stay in the background and provide support as needed. For each monthly Cafe in each town, we also organize a follow-up meeting, in which the participants explore some aspect of the month's topic in greater depth. We seek "hands-on" activities, but the follow-ups may also be field trips, visits to science-related organizations, or simply another meeting in the Cafe format in which a different point of view is presented. The Cafes are popular with the scientist-presenters as well. We work with them to develop their presentations, a 1-page essay, and a 1- page highly personalized bio. It is a particular challenge to get the scientists to give presentations appropriate for the youth and the informal setting, as opposed to what they are used to, presentations to peers at AGU meetings and the like. But typically, after some initial trepidation, they rise to the occasion. We are now seeking to make our model and our experience available to others who may wish to try a youth Cafe experiment themselves.

Role of uncontrolled HIV RNA level and immunodeficiency in the occurrence of malignancy in HIV-infected patients during the combination antiretroviral therapy era: Agence Nationale de Recherche sur le Sida (ANRS) CO3 Aquitaine Cohort.

PubMed

Bruyand, Mathias; Thiébaut, Rodolphe; Lawson-Ayayi, Sylvie; Joly, Pierre; Sasco, Annie Jeanne; Mercié, Patrick; Pellegrin, Jean Luc; Neau, Didier; Dabis, François; Morlat, Philippe; Chêne, Geneviève; Bonnet, Fabrice

2009-10-01

Human immunodeficiency virus (HIV)-infected patients are at higher risk of malignancies. In addition to traditional determinants, a specific deleterious effect of HIV and immunodeficiency is speculated. We aimed at studying the association between immunological and virological characteristics of HIV-infected patients in care and the risk of acquired immunodeficiency syndrome (AIDS)-defining and non-AIDS-defining malignancies. Patients consecutively enrolled in the hospital-based Agence Nationale de Recherche sur le Sida (ANRS) CO3 Aquitaine Cohort were included if the duration of follow-up was >3 months during the period 1998-2006. Multivariate modeling used an extended Cox proportional hazards model for time-dependent covariates and delayed entry. The 4194 patients included in the study developed 251 first malignancies during 22,389 person-years. A higher incidence of AIDS-defining malignancies (107 cases) was independently associated with (1) both longer and current exposures to a plasma HIV RNA level >500 copies/mL (hazard ratio [HR], 1.27 per year [P<.001] and 3.30 [P<.001], respectively) and (2) both longer and current exposure to a CD4(+) cell count <200 cells/mm(3) (HR, 1.36 per year [P<.001] and 6.33 [P<.001], respectively). A higher incidence of non-AIDS-defining malignancies (144 cases) was independently associated with longer and current exposure to a CD4(+) cell count <500 cells/mm(3) (HR, 1.13 per year [P=.01] and 2.07 [P<.001], respectively) and male sex (HR, 1.69; P=.02) but not with plasma HIV RNA level (P=.49 and P=.10 for cumulative and current exposures, respectively). Uncontrolled plasma HIV RNA level was independently associated with a higher likelihood of developing AIDS-defining malignancies, whereas immunosuppression was associated with a higher risk of developing any type of malignancies. Antiretroviral treatment should aim at reaching and maintaining a CD4(+) count >500 cells/mm(3) to prevent the occurrence of malignancy, this should be integrated to malignancy-prevention policies.

Prognostic relevance of Fédération Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases.

PubMed

Jour, George; Gullet, Ashley; Liu, Mingdong; Hoch, Benjamin L

2015-01-01

Dedifferentiated liposarcoma represents a form of liposarcoma composed of a non-lipogenic sarcoma associated with well-differentiated liposarcoma. The prognostic significance of histological grading of the dedifferentiated component remains to be elucidated due to vague grading criteria employed in previous studies. Molecular markers of tumor behavior, including amplification levels of murine double minute-2 (MDM2) and cyclin-dependent kinase-4 (CDK4) genes, have been explored in a limited number of cases. Here we investigate whether 'Fédération Nationale des Centres de Lutte Contre le Cancer' (FNCLCC) grade and MDM2 gene amplification levels have prognostic value in dedifferentiated liposarcoma in terms of local recurrence and disease-specific survival. Fifty cases were retrieved, reviewed and FNCLCC grade was scored for the dedifferentiated component. Testing for MDM2 gene amplification was performed by fluorescence in situ hybridization. Amplification was categorized as high level (≥20 copies) and as low level (<20 copies). Follow-up data was obtained through chart review. Log-rank test and Cox proportional hazard models were used to determine the effect of grade and level of MDM2 amplification on outcomes. Our series includes 50 patients (male n=28, female n=22) with an average age of 63 years (range, 28-88) and a median follow-up of 28 months (range, 2-120). Tumors were graded as grade 1 (6%), grade 2 (58%), and grade 3 (36%). When adjusted for age, sex, site, tumor size, and margin status, grade 3 patients had a higher recurrence rate than grades 1 and 2 (HR=2.07, 95% CI: 1.24, 7.62; P=0.015). Patients with high-level MDM2 amplification had higher recurrence rate on univariate analysis (P=0.028), but not on multivariate analysis (HR=1.69, 95% CI: 0.73, 3.94; P=0.221). FNCLCC grade 3 dedifferentiation confers a worse prognosis in dedifferentiated liposarcoma in terms of local recurrence. MDM2 amplification level remains a useful diagnostic tool in dedifferentiated liposarcoma, but has no prognostic value in terms of local recurrence.

3. Côte D'Ivoire

NASA Astrophysics Data System (ADS)

Cisse, M'badiala

1996-01-01

Entreprendre une recherche sur la politique et la législation en matière d'éducation des adultes, qui couvre plusieurs secteurs, paraît une gageure pour plusieurs raisons: difficultés dans la constitution de plusieurs équipes de recherche avec plusieurs spécialistes ou personnes ressources, difficultés dans la collecte des données, étendue et complexité des domaines à explorer et des points à prendre en compte dans la rédaction, etc. En dépit de ces difficultés majeures, l'essentiel du travail a été accompli dans le souci de respecter les exigences imposées. A l'analyse, nous constatons que plusieurs partenaires interviennent dans la formation, l'éducation et l'encadrement des adultes, et que dans le secteur public, les structures ne sont pas "logées à la même enseigne": Si la formation professionnelle a bénéficié de conditions réellement favorables pour son expansion et son développement, les autres secteurs, sans avoir été négligés, n'ont pas connu les mêmes faveurs. Ainsi plusieurs lois et mesures importantes ont été votées et prises en vue de la dynamisation de la formation professionnelle, alors que le secteur de l'agriculture, qui est la base de succès du développement du pays et occupe 55% de la population, n'a pas bénéficié d'une véritable politique éducative en faveur des agriculteurs. Il en est de même pour l'alphabétisation. On déplore constamment l'absence de politique élaborée et appliquée à l'échelle nationale. Aucune mesure politique n'a été votée par l'Assemblée nationale, alors que l'alphabétisation devrait constituer le levier du développement de l'éducation des adultes en Côte d'lvoire.

Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort.

PubMed

Fagherazzi, Guy; Vilier, Alice; Saes Sartorelli, Daniela; Lajous, Martin; Balkau, Beverley; Clavel-Chapelon, Françoise

2013-03-01

It has been extensively shown, mainly in US populations, that sugar-sweetened beverages (SSBs) are associated with increased risk of type 2 diabetes (T2D), but less is known about the effects of artificially sweetened beverages (ASBs). We evaluated the association between self-reported SSB, ASB, and 100% fruit juice consumption and T2D risk over 14 y of follow-up in the French prospective Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. A total of 66,118 women were followed from 1993, and 1369 incident cases of T2D were diagnosed during the follow-up. Cox regression models were used to estimate HRs and 95% CIs for T2D risk. The average consumption of sweetened beverages in consumers was 328 and 568 mL/wk for SSBs and ASBs, respectively. Compared with nonconsumers, women in the highest quartiles of SSB and ASB consumers were at increased risk of T2D with HRs (95% CIs) of 1.34 (1.05, 1.71) and 2.21 (1.56, 3.14) for women who consumed >359 and >603 mL/wk of SSBs and ASBs, respectively. Strong positive trends in T2D risk were also observed across quartiles of consumption for both types of beverage (P = 0.0088 and P < 0.0001, respectively). In sensitivity analyses, associations were partly mediated by BMI, although there was still a strong significant independent effect. No association was observed for 100% fruit juice consumption. Both SSB consumption and ASB consumption were associated with increased T2D risk. We cannot rule out that factors other than ASB consumption that we did not control for are responsible for the association with diabetes, and randomized trials are required to prove a causal link between ASB consumption and T2D.

[Lemierre's syndrome: Diagnosis, exploration, treatment].

PubMed

Mesrar, H; Mesrar, J; Maillier, B; Kraoua, S; Chapoutot, L; Delclaux, B

2018-05-01

Lemierre's syndrome is a rare and severe sepsis that can rapidly lead to a life-threatening condition in the absence of early management. This syndrome described at the beginning of the 20th century combines oropharyngeal infection complicated with septic thrombosis of the internal jugular vein and septic emboli predominantly pulmonary. Fusobacterium necrophorum, anaerobic germ, Gram negative bacillus is the main germ in this "necrobacillosis". The diagnosis is should be confirmed precociously with cervicothoracic CT-scan, reference exam, and bacteriological examinations (especially in atypical forms). Its management consists of an emergency antibiotic treatment, combining a third-generation cephalosporin or a betalactam with metronidazole, anticoagulant therapy to be reserved for high-risk situations related to thrombosis. Surgical treatment may be required. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Guidelines for the treatment of hemorrhoids (short report).

PubMed

Higuero, T; Abramowitz, L; Castinel, A; Fathallah, N; Hemery, P; Laclotte Duhoux, C; Pigot, F; Pillant-Le Moult, H; Senéjoux, A; Siproudhis, L; Staumont, G; Suduca, J M; Vinson-Bonnet, B

2016-06-01

Hemorrhoids are a common medical problem that is often considered as benign. The French Society of Colo-Proctology (Société nationale française de colo-proctologie [SNFCP]) recently revised its recommendations for the management of hemorrhoids (last issued in 2001), based on the literature and consensual expert opinion. We present a short report of these recommendations. Briefly, medical treatment, including dietary fiber, should always be proposed in first intention and instrumental treatment only if medical treatment fails, except in grade ≥III prolapse. Surgery should be the last resort, and the patient well informed of the surgical alternatives, including the possibility of elective ambulatory surgery, if appropriate. Postoperative pain should be prevented by the systematic implementation of a pudendal block and multimodal use of analgesics. Copyright © 2016. Published by Elsevier Masson SAS.

[The revolution of monoclonal antibodies in the treatment of thrombotic microangiopathy].

PubMed

Sauvètre, G; Grange, S; Froissart, A; Veyradier, A; Coppo, P; Benhamou, Y

2015-05-01

Thrombotic microangiopathies (TMA) define a syndrome characterized by the association of microangiopathic haemolytic anaemia with schistocytes, peripheral thrombocytopenia, and organ injury of variable severity. Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uremic syndrome (HUS) are the main forms of TMA. Recent advances in the pathophysiology of those two diseases, which include in HUS the identification of a deregulation of the alternative complement pathway, and in TTP a severe deficiency in ADAMTS-13, allowed to develop specific, pathophysiology-based therapies. Therefore, rituximab and eculizumab tends to be increasingly used, and there is an urgent need to define consensual modes of administration at the international level, as well as common definitions of response evaluation and follow-up explorations. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Decontamination of organophosphorus compounds: Towards new alternatives].

PubMed

Poirier, L; Jacquet, P; Elias, M; Daudé, D; Chabrière, E

2017-05-01

Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. This review summarizes the current and emerging strategies that are investigated to tackle this issue with a special emphasis on enzymatic remediation methods. During the last decade, many studies have been dedicated to the development of biocatalysts for OP removal. Among these, recent reports have pointed out the promising enzyme SsoPox isolated from the archaea Sulfolobus solfataricus. Considering both its intrinsic stability and activity, this hyperthermostable enzyme is highly appealing for the decontamination of OP. Copyright © 2017 Académie Nationale de Pharmacie. All rights reserved.

[Relapse of acute promyelocytic leukemia in the central nervous system revealed by isolated dementia].

PubMed

Colin, O; Julian, A; Puyade, M; Bouyer, S; Meurin, E; Blondeau, S; Houeto, J L; Neau, J P

2016-12-01

Approximately 1.5% of dementia is due to curable aetiology. We report an isolated dementia syndrome due to a meningeal relapse of acute promyelocytic leukaemia with favourable outcome after appropriate treatment. A 72-year-old woman, in remission of an acute promyelocytic leukaemia, presented a loss of autonomy for several months due to corticosubcortical dementia. Lumbar puncture showed blast cells indicating meningeal relapse of leukaemia. Intrathecal chemotherapy and arsenic trioxide obtained biological and molecular remission as well as restoration of normal cognitive functions. In patients with hematologic past history such as acute promyelocytic leukaemia, an isolated cognitive impairment should alert physicians to search for an isolated neuromeningeal relapse. Copyright © 2016 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Mondor's disease of penis: A case report].

PubMed

Marsaudon, E; Legal, C; Gayoux, D; Weber, O

2016-09-01

Mondor's disease is a rare superficial thrombophlebitis, historically involving the thoracic venous system of women. However, it can occur in both gender and all over the skin. We report a 40-year-old man with type one diabetes who presented with a thrombosis of the superficial dorsal vein of the penis that he treated as a fungal infection. Treatment with non-steroidal anti-inflammatory drugs and low molecular weight heparin contributed to a favorable outcome in 2 weeks. Pathogenesis and treatment of Mondor's disease remain incompletely dominated. Some predisposing factors have been highlighted in the literature. It might be interesting to add diabetes, due to its frequent pelvic problems leading to a potential venous inflammatory trigger. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Sarcoidosis flare after autologous stem cell transplantation: An immune paradox?

PubMed

Marchal, A; Charlotte, F; Maksud, P; Haroche, J; Lifferman, F; Miyara, M; Choquet, S; Amoura, Z; Cohen Aubart, F

2017-09-01

Sarcoidosis is a systemic granulomatous disorder of unknown cause. Apparition or flare of previously diagnosed sarcoidosis following hematopoietic stem cell transplantation (HSCT) has rarely been reported. We report a 62-year-old woman who presented a radiological flare of sarcoidosis post-autologous stem cell transplantation for a POEMS syndrome. Imaging findings and lymph node histology, which revealed non-caseating granuloma, were consistent with the sarcoidosis diagnosis. The patient was asymptomatic and was kept free of treatment. Sarcoidosis must be considered ahead of compatible clinicoradiological presentation occurring after HSCT. Sarcoidosis can mimic metastatic cancer or lymphatic relapse. Tissue biopsies and exclusion of differential diagnosis of granuloma diseases are warranted to confirm sarcoidosis diagnosis. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Clopidogrel induced thrombotic thrombocytopenic purpura].

PubMed

Karkowski, L; Wolf, M; Lescampf, J; Coppérré, B; Veyradier, A; Ninet, J; Hot, A

2011-12-01

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder. Drug-induced TTP is uncommon and we report a TTP associated with the use of clopidogrel. We report a 50-year-old man who presented with acute myocardial infarction and received clopidogrel therapy. He developed acute TTP ten days after clopidogrel onset. Imputability of the drug was demonstrated during a reintroduction test. Deficiency of ADAMTS 13 was confirmed and autoantibodies against ADAMTS 13 were detected. Complete remission was obtained after 24 plasma exchange sessions and adjunction of corticosteroids. Drug-induced TTP are probably immunologic, as was demonstrated in our patient. Clinicians should be aware of this possible uncommon adverse effect of clopidogrel because prompt therapy is imperative for life saving. Copyright © 2011 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Electric-field control of spin waves in multiferroic BiFeO3: Theory

NASA Astrophysics Data System (ADS)

de Sousa, Rogério; Rovillain, P.; Gallais, Y.; Sacuto, A.; Méasson, M. A.; Colson, D.; Forget, A.; Bibes, M.; Barthélémy, A.; Cazayous, M.

2011-03-01

Our recent experiment demonstrated gigantic (30%) electric-field tuning of magnon frequencies in multiferroic BiFeO3. We demonstrate that the origin of this effect is related to two linear magnetoelectric interactions that couple the component of electric field perpendicular to the ferroelectric vector to a quadratic form of the Néel vector. We calculate the magnon spectra due to each of these interactions and show that only one of them is consistent with experimental data. At high electric fields, this interaction induces a phase transition to a homogeneous state, and the multi-magnon spectra will fuse into two magnon frequencies. We discuss the possible microscopic mechanisms responsible for this novel interaction and the prospect for applications in magnonics. We acknowledge support from NSERC-Discovery (Canada) and the Agence Nationale pour la Recherche (France).

[National ethics committees and representative democracy: is the new German ethics committee more "democratic"?].

PubMed

Dagron, Stéphanie

2007-01-01

The bill passed in April 2007 by the German parliament aims to confer democratic legitimacy on the German Ethics Committee (deutscher Ethikrat) which has replaced the former National Ethics Committee (nationaler Ethikrat) set up in 2001. This law results from a wide debate which began in 2005 within the political parties about the role in democracy of the bodies charged with advising the people's representatives in the areas of biotechnology and modern medicine. In this article, the author explains why it was necessary to confer a certain democratic legitimacy on the new Ethics Committee and analyses the relation that exists between the democratic principle, the work of this type of committee and the national institutional structure retained to stimulate the debate and advise the political decision-makers, and even to prepare legislation concerning bioethics.

[The French National Compound Library: advances and future prospects].

PubMed

Mahuteau-Betzer, Florence

2015-04-01

The French National Compound Library (Chimiothèque Nationale) has been created in 2003 and is the federation of local collections. It contains more than 56 000 small molecules and natural compounds synthesised or isolated in different laboratories over the past years. This explains the diversity of the collection. The strength of this initiative is the ability to connect chemists and biologists for the development of hits. This development involves the synthesis of analogues or/and chemical tools to find new targets. These collaborations lead to the identification of new chemical probes. These probes able to modulate a biological function are essential to study biological pathways. They can also be useful for therapeutic applications. This article will describe the major achievements and perspectives of the French Chemical Library. © 2015 médecine/sciences – Inserm.

Foreword

NASA Astrophysics Data System (ADS)

Boutron, Claude; Ferrari, Christophe

2003-05-01

It is our pleasure to host the “12th International Conference on Heavy Metals in the Environment” in the city of Grenoble (France), in the heart of the Alps. This is the latest in this successful and popular series of conferences, which previously took place in Toronto (1975), London (1979), Amsterdam (1981), Heidelberg (1983), Athens (1985), New Orleans (1987), Geneva (1989), Edinburgh (1991), Hamburg (1995) and Ann Arbor (2000). Grenoble is one of the major research centres in Europe, with a very large number of researchers in various fields, especially Physics and Chemistry, Mathematics and Computer Sciences, Biology and Medicine, and Earth and Universe Sciences. There are two internationally recognized scientific Universities: Université Joseph Fourier (UJF), and Institut National Polytechnique de Grenoble (INPG). There are also the main research laboratories of various French and European governmental organizations such as Commissariat à l'énergie Atomique (CEA), Centre National de la Recherche Scientifique (CNRS), Institut Laue Langevin (ILL), European Synchrotron Radiation Facility (ESRF) and Institut de Radio-Astronomie Millimètrique (IRAM). Finally, there are various hi-tech companies such as Hewlett Packard, ST Microelectronics, Schneider Electric and SGS-Thomson. There is a long tradition of research in the field of heavy metals in the environment, especially at the Laboratoire de Glaciologie et Géophysique de l'Environnement and at the Laboratoire de Géophysique Interne et Tectonophysique. These two volumes contain papers presented both in oral and poster sessions. The papers are not organised in order of presentation, but according to the alphabetical order of the family name of the first author of each paper. It is our pleasure to thank the authors for the excellent level of their submissions. We are also particularly grateful to Isabelle Houlbert and Laurence Castagné for editorial assistance. We would like to take this opportunity to thank the members of the organising committee and Jerome Nriagu (chairman of the 11th Conference) for helping us to put together the program of this conference. Also, very special thanks are due to Christine Echevet for her continuous and expert efforts to make the Grenoble Conference a success, and to various members of the Laboratoire de Glaciologie et Géophysique de l'Environnement, especially Jocelyne Roquemora. Special thanks are also due to the President of Grenoble Alpes Métropole and the Mayor of the City of Grenoble. Finally, we are very grateful to the various co-sponsors of the conference, especially the Centre National de la Recherche Scientifique (CNRS), the University Joseph Fourier of Grenoble, the Ministère des Affaires Étrangères, the Ministère de l'Écologie et du Développement Durable, the Agence de l'Environnement et de la Maîtrise de l'Énergie (ADEME), Grenoble Alpes Métropole (La Métro), the City of Grenoble, the Region Rhône-Alpes, the Conseil Général de l'Isère, the Association Minéraux, Métaux non ferreux, Santé, Environnement (AMSE), the University of Michigan and the Société Hydrotechnique de France (SHF). Claude BOUTRON and Christophe FERRARI - Conference Co-Chairmen 12th International Conference on Heavy Metals in the Environment, Grenoble, France, 26-30 May 2003 Préface C'est un grand plaisir pour nous d'accueillir la “12e Conférence Internationale sur les Métaux Lourds dans l'Environnement en France Grenoble, au coeur des Alpes. Cette conférence est la 12e du nom, après celles qui ont eu lieu avec beaucoup de succès à Toronto (1975), Londres (1979), Amsterdam (1981), Heidelberg (1983), Athènes (1985), La Nouvelle Orléans (1987), Genève (1989), Edimbourg (1991), Hambourg (1995) et Ann Arbor (2000). Grenoble est l'une des principales ville d'Europe pour la recherche scientifique avec un très grand nombre de chercheurs dans des domaines trés variés, notamment en Physique et Chimie, Mathématiques et Informatique, Biologie et Médecine, et Sciences de la Terre et de l'Univers. Il y a deux grandes Universités Scientifiques de renommée internationale: l'Université Joseph Fourier (UJF) et l'Institut National Polytechnique de Grenoble (INPG). Il y a aussi d'importants laboratoires de différents organismes publics français et européen comme le Commissariat à l'Énergie Atomique (CEA), le Centre National de la Recherche Scientifique (CNRS), l'Institut Laue Langevin (ILL), l'European Synchrotron Radiation Facility (ESRF) et l'Institut de Radio-Astronomie Millimètrique (IRAM). C'est aussi le lieu d'implantation de nombreuses sociétés de haute technologie comme Hewlett Packard, ST Microelectronics, Schneider Electric and SGS-Thomson. Il a à Grenoble une longue tradition de recherches dans le domaine des métaux lourds dans l'environnement, notamment au Laboratoire de Glaciologie et Géophysique de l'Environnement et au Laboratoire de Géophysique Interne et Tectonophysique. Ces deux volumes regroupent les articles issus de communication présentées aussi bien au cours des sessions orales que des sessions posters. Ces articles sont classés selon l'ordre alphabétique du nom de famille du premier auteur. Nous remercions vivement les auteurs pour l'excellente qualité de ces articles. Nous remercions aussi tout particulièrement Isabelle Houlbert et Laurence Castagné pour leur collaboration. Nous aimerions aussi remercier les membres du comité d'organisation ainsi que Jerome Nriagu (organisateur de la 11e conférence) pour l'aide apportée à l'organisation de cette conférence. Nous remercions aussi tout spécialement Christine Echevet qui n'a pas ménagé ses efforts pour faire de cette conférence un succés, ainsi que de nombreux collègues du Laboratoire de Glaciologie et Géophysique de l'Environnement, en particulier Jocelyne Roquemora. Nous tenons également à remercier le Président de Grenoble Alpes Métropole et le Maire de la Ville de Grenoble pour leur soutien. Cette conférence n'aurait pas pu avoir lieu sans le soutien financier de nombreux organismes: le Centre National de la Recherche Scientifique (CNRS), l'Université Joseph Fourier de Grenoble, le Ministère des Affaires Étrangères, le Ministère de l'Écologie et du Développement Durable, l'Agence de l'Environnement et de la Maîtrise de l'Énergie (ADEME), Grenoble Alpes Métropole (La Métro), la Ville de Grenoble, La Région Rhône-Alpes, le Conseil Général de l'Isère, l'Association Minéraux, Métaux non ferreux, Santé, Environnement (AIMSE), l'Université du Michigan et la Société Hydrotechnique de France (SHF). Claude BOUTRON et Christophe FERRARI Co-organisateurs de la 12e Conférence Internationale sur les Métaux Lourds dans l'Environement, Grenoble, France, 26-30 Mai 2003

Effects of Self-Esteem and Mortality Salience on Attitudes Toward Canadian Security: Exploring the Significance of Implicit-Explicit and Personal-Collective Distinctions (Les Effets de L’Estime de soi et de la Pregnance de la Mort sur les Attitudes a L’Egard de la Securite Canadienne: Analyse de L’Importance des Distinctions entre Implicite et Explicite d’une Part et entre Personnel et Collectif D’Autre Part)

DTIC Science & Technology

2011-04-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC Toronto TR... la gestion de la terreur, c’est parce que les êtres humains sont les seuls à posséder la capacité de comprendre la finitude de la vie qu’ils ont...entre autres l’adhésion à une vision du monde culturellement significative et un sentiment de sécurité basé sur l’estime de soi. À ce jour,

42nd Congress of the "Groupe Français des Pesticides" (French Group of Pesticide research--GFP 2012) ENSIP, Poitiers, France, 30 May-1 June 2012.

PubMed

Chollet, Jean-François; Couderchet, Michel; Bonnemain, Jean-Louis

2014-04-01

The 42nd congress of the "Groupe Français des Pesticides" (French Group of Pesticide research--GFP 2012) took place 30 May-1 June at the "École Nationale Supérieure d’Ingénieurs de Poitiers" (ENSIP), a French generalist engineering grande école in Poitiers. Its focus is on the protection of the environment and is part of the University of Poitiers, one of the oldest universities in Europe. GFP is an annual conference where the latest developments in the field of pesticide research are presented. The topics most commonly discussed mainly concern environmental quality, monitoring, fate, and transfer of pesticides in the environment or risks associated with use of pesticides, but every year a key theme sets the tone. For this 42nd edition, the theme "Innovative strategies for plant protection" was retained.

Molecular spectroscopy for producing ultracold ground-state NaRb molecules

NASA Astrophysics Data System (ADS)

Wang, Dajun; Guo, Mingyang; Zhu, Bing; Lu, Bo; Ye, Xin; Wang, Fudong; Vexiau, Romain; Bouloufa-Maafa, Nadia; Quéméner, Goulven; Dulieu, Olivier

2016-05-01

Recently, we have successfully created an ultracold sample of absolute ground-state NaRb molecules by two-photon Raman transfer of weakly bound Feshbach molecules. Here we will present the detailed spectroscopic investigations on both the excited and the rovibrational ground states for finding the two-photon path. For the excited state, we focus on the A1Σ+ /b3 Π singlet and triplet admixture. We discovered an anomalously strong coupling between the Ω =0+ and 0- components which renders efficient population transfer possible. In the ground state, the pure nuclear hyperfine levels have been clearly resolved, which allows us to create molecules in the absolute ground state directly with Raman transfer. This work is jointly supported by Agence Nationale de la Recherche (#ANR-13- IS04-0004-01) and Hong Kong Research Grant Council (#A-CUHK403/13) through the COPOMOL project.

Spontaneous actin dynamics in contractile rings

NASA Astrophysics Data System (ADS)

Kruse, Karsten; Wollrab, Viktoria; Thiagarajan, Raghavan; Wald, Anne; Riveline, Daniel

Networks of polymerizing actin filaments are known to be capable to self-organize into a variety of structures. For example, spontaneous actin polymerization waves have been observed in living cells in a number of circumstances, notably, in crawling neutrophils and slime molds. During later stages of cell division, they can also spontaneously form a contractile ring that will eventually cleave the cell into two daughter cells. We present a framework for describing networks of polymerizing actin filaments, where assembly is regulated by various proteins. It can also include the effects of molecular motors. We show that the molecular processes driven by these proteins can generate various structures that have been observed in contractile rings of fission yeast and mammalian cells. We discuss a possible functional role of each of these patterns. The work was supported by Agence Nationale de la Recherche, France, (ANR-10-LABX-0030-INRT) and by Deutsche Forschungsgemeinschaft through SFB1027.

[Starvation ketosis in a breastfeeding woman].

PubMed

Monnier, D; Goulenok, T; Allary, J; Zarrouk, V; Fantin, B

2015-12-01

Bovine ketosis is a rare cause of metabolic acidosis. It is a starvation ketosis that appears in lactating woman. A 29-year-old woman had a previous gastric surgery one month ago while breastfeeding her 6-month child. She presented to emergency with dyspnea, fatigue, weight loss and anorexia. The explorations revealed a serious metabolic acidosis with a high anion gap, for which all other causes have been eliminated. A restrictive diet in lactating patients is a major risk of ketosis or bovine ketosis. Medico-surgical treatment of obesity during lactation seems unreasonable. Breastfeeding should be systematically sought before a medical and surgical management of obesity. With the spread of bariatric surgery, starvation ketosis is a cause of metabolic acidosis not to ignore. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Castleman's disease: Rapid desensitization for hypersensitivity reaction to rituximab].

PubMed

Boin, C; Lambert, S; Thomann, P; Aujoulat, O; Kieffer, P

2016-06-01

Rapid desensitization allows secure administration of a drug and is indicated when there is no therapeutic alternative. We report a 49-year-old patient who presented with a hypersensitivity reaction following an infusion of rituximab (375mg/m(2)) in the context of a Castleman's syndrome. After a clinical flare (splenomegaly, adenopathies) despite treatment with tocilizumab, anakinra and valganciclovir, the reintroduction of rituximab was decided, according to the rapid desensitization protocol. Four full dose desensitizations were successfully performed allowing immediate clinical improvement (apyrexia, loss of sweating and lymphadenopathy, splenomegaly partial regression) and biological (negativation of HHV8 viral load, and disappearance of neutropenia, anemia and thrombocytopenia). Rapid desensitization is a promising method for the pursuit of rituximab therapy after a hypersensitivity reaction and should be considered in patients with no acceptable therapeutic alternative. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

How was the UNAIDS drug access initiative implemented in Chile?

PubMed Central

Brousselle, Astrid; Champagne, François

2012-01-01

In 1997, UNAIDS decided to implement Drug Access Initiatives (DAI) in four different pilot-countries. We studied the implementation of the DAI in Chile as part of the evaluation program conducted by the ‘Agence Nationale de Recherche sur le SIDA’ (ANRS/France). The objective was to understand how the politico-organizational dynamic influenced the implementation process of the DAI. Approximately 50 semi-directed interviews and observation activities were conducted with the actors who participated in the implementation of the DAI or who played a role in the HIV/AIDS context. The program theory models were established and their evolution analyzed. This article offers an original analysis of an international HIV/AIDS drug access program that was put in place at a time when such programs were seen as a priority by international and governmental institutions. It also offers some insights for the creation of international projects that will be locally implemented. PMID:23230344

[A Listeria breast abscess in a man].

PubMed

Marsaudon, E; Berthy, J; Mamoune, S; Deniel, A; Ksiyer, S; Tiuca, D

2018-03-01

Listeriosis is a food-borne illness leading to bacteriemia or central nervous system infection especially in pregnant women or high-risk patients. It is rarely a localized infection. Breast contamination has rarely been reported in lactating women. We report a breast abscess in man. A 80 year old man, hypertensive and arrhythmic, was explored for weakness and dehydration. Type 2 diabetes and chronic lymphocytic leukemia were diagnosed. Clinical examination disclosed a breast abcess related to L monocytogenes infection. Histopathological study also revealed a breast subcutaneous infiltration by chronic lymphocytic leukemia. Listeriosis sometimes uncover an unknown immunosuppression, especially in the elderly. Breast is a non-sterile tissue containing a stable microbiome partly from digestive origin. It can thereby be contaminated by Listeria. The specific cutaneous infiltrate of chronic lymphocytic leukemia can create the conditions for a local infection. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

High oxygen affinity hemoglobins.

PubMed

Mangin, O

2017-02-01

High oxygen affinity hemoglobins are responsible for rare and heterogeneous autosomic dominant genetic diseases. They cause pure erythrocytosis, sometimes accountable for hyperviscosity and thrombosis, or hemolysis. Differential diagnoses must be first ruled out. The diagnosis is based on the identification of a decreased P50, and their possible characterization by cation exchange-high performance liquid chromatography and capillary electrophoresis. Finally, genetic studies of the responsible globin chain gene will confirm the mutation. The prognosis mainly relies on the P50 decrease rate and on the hemoglobin cooperativity impairment. Disease management should be personalized, and it should primarily depend on smoking cessation and physical activity. Phlebotomy and platelet aggregation inhibitors' prescriptions can be discussed. There is no contraindication to flights, high-altitude conditions, or pregnancy. Nevertheless, blood donation must be prohibited. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Opportunistic infections and sarcoidosis].

PubMed

Jamilloux, Y; Bernard, C; Lortholary, O; Kerever, S; Lelièvre, L; Gerfaud-Valentin, M; Broussolle, C; Valeyre, D; Sève, P

2017-05-01

Opportunistic infections (OI) are uncommon in sarcoidosis (1 to 10%) and mostly occur in patients with previously diagnosed disease or can rarely be the presenting manifestation. The most common OIs are, in descending order: aspergillosis, cryptococcosis, and mycobacterial infections. Treatment with corticosteroids is the most frequent risk factor for OI occurrence during sarcoidosis but immunosuppressive drugs and therapy with anti-TNFα are also risk factors. Overall, clinical presentation, treatment, and outcome are identical to that occur in other conditions complicated with the occurrence of OIs. However, some atypical presentations of OIs can mimic sarcoidosis exacerbation and misdiagnosis may lead clinicians to increase immunosuppression, causing worsening of the OI. The meticulous collection of patient's history along with factors differentiating OI from sarcoidosis exacerbation is key factor to optimally manage these patients. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

X-ray crystallography, an essential tool for the determination of thermodynamic relationships between crystalline polymorphs.

PubMed

Céolin, R; Rietveld, I-B

2016-01-01

After a short review of the controversies surrounding the discovery of crystalline polymorphism in relation to our present day understanding, the methods of how to solve the stability hierarchy of different polymorphs will be briefly discussed. They involve either theoretical calculations, or, more commonly, experimental methods based on classical thermodynamics. The experimental approach is mainly carried out using heat-exchange data associated to the transition of one form into another. It will be demonstrated that work-related data associated to the phase transition should be taken into account and the role of X-ray crystallography therein will be discussed. X-ray crystallography has become increasingly precise and can nowadays provide specific volumes and their differences as a function of temperature, and also as a function of pressure, humidity, and time. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[An atypical form of neurosarcoidosis].

PubMed

Quenardelle, V; Benmekhbi, M; Aupy, J; Dalvit, C; Hirsch, E; Benoilid, A

2013-12-01

Nervous system involvement occurs in 5 to 15% of the patients with sarcoidosis. Neurosarcoidosis remains very difficult to diagnose because clinical presentation and imaging characteristics lack specificity. We report a 26-year-old man who gradually developed headaches, memory disturbance and epilepsy. CT-scan and MRI showed a temporal-parietal cystic mass, secondary to a rare and focal form of hydrocephalus, called "trapped temporal horn" revealing neurosarcoidosis. The "entrapped temporal horn" is due to an obstacle on the cerebrospinal fluid pathway at the trigone of the lateral ventricle that seals off the temporal horn and the choroid plexus from the rest of the ventricular system. The obstacle is related to the granulomatous tissue of sarcoidosis. Therefore, the "trapped temporal horn" acts as a space occupying process, causing headaches, memory pain, hemiparesis, homonymous hemianopsia, and requires medico-surgical management. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

(Low-level waste disposal facility siting and site characterization)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mezga, L.J.; Ketelle, R.H.; Pin, F.G.

A US team consisting of representatives of Oak Ridge National Laboratory (ORNL), Savannah River Plant (SRP), Savannah river Laboratory (SRL), and the Department of Energy Office of Defense Waste and Byproducts Management participated in the fourth meeting held under the US/French Radioactive Waste Management Agreement between the US Department of Energy and the Commissariat a l'Energie Atomique. This meeting, held at Agence Nationale pour les Gestion des Dechets Radioactifs' (ANDRA's) Headquarters in Paris, was a detailed, technical topical workshop focusing on Low-Level Waste Disposal Facility Siting and Site Characterization.'' The meeting also included a visit to the Centre de lamore » Manche waste management facility operated by ANDRA to discuss and observe the French approach to low-level waste management. The final day of the meeting was spent at the offices of Societe Generale pour les Techniques Nouvelles (SGN) discussing potential areas of future cooperation and exchange. 20 figs.« less

[Systemic sclerosis: Efficacy of intravenous immunoglobulins in severe cardiac involvement?

PubMed

Cacciatore, C; Riviere, S; Cohen, A; Gatfosse, M; Ederhy, S; Fain, O; Mekinian, A

2018-07-01

The heart involvement in systemic sclerosis is frequent and can touch various sites. The prognosis in the presence of heart disease is poor, but few data are available about its management. We report the case of 48 years old woman with systemic sclerosis which presented severe heart involvement. She has severe heart failure, supraventricular arrhythmias and symptomatic pericarditis, which required surgical intervention and immunosuppressive drugs (steroids with rituximab). Despite this treatment, she has persistent severe heart impaired function and intravenous immunoglobulins have been initiated. She experienced progressively the improvement of dyspnea, of heart systolic ejection fraction and decrease of Rodnan scale. Our case illustrates a severe heart involvement in systemic sclerosis which have been improved by intravenous immunoglobulins. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

The new powder diffractometer D1B of the Institut Laue Langevin

NASA Astrophysics Data System (ADS)

Puente Orench, I.; Clergeau, J. F.; Martínez, S.; Olmos, M.; Fabelo, O.; Campo, J.

2014-11-01

D1B is a medium resolution high flux powder diffractometer located at the Institut Laue Langevin, ILL. D1B a suitable instrument for studying a large variety of polycrystalline materials. D1B runs since 1998 as a CRG (collaborating research group) instrument, being exploited by the CNRS (Centre National de la Recherche Scientifique, France) and CSIC (Consejo Superior de Investigaciones Cientificas, Spain). In 2008 the Spanish CRG started an updating program which included a new detector and a radial oscillating collimator (ROC). The detector, which has a sensitive height of 100mm, covers an angular range of 128°. Its 1280 gold wires provide a neutron detection point every 0.1°. The ROC is made of 198 gadolinium- based absorbing collimation blades, regular placed every 0.67°. Here the present characteristics of D1B are reviewed and the different experimental performances will be presented.

25th Birthday Cern- Restaurant

ScienceCinema

None

2017-12-09

Cérémonie du 25ème anniversaire du Cern avec plusieurs orateurs et la présence de nombreux autorités cantonales et communales genevoises et personnalités, directeurs généraux, ministres, chercheurs.... Le conseiller féderal et chef du département des affaires étrangères de la confédération Monsieur Pierre Aubert prend la parole pour célébrer à la fois les résultats très remarquables de la coopération internationale en matière scientifique, mais aussi la volonté politique des états européens de mettre en commun leurs ressources pour faire oeuvre d'avenir. Un grand hommage est aussi donné aux deux directeurs disparus, les prof.Bakker et Gregory.

Georges Lemaître and Stigler's Law of Eponymy

NASA Astrophysics Data System (ADS)

Block, David L.

One of the greatest discoveries of modern times is that of the expanding Universe, almost invariably attributed to Hubble (Proceedings of the National Academy of Sciences of the United States of America 15:168, 1929). What is not widely known is that the original treatise by Lemaître (Annales de la Société Scientifique de Bruxelles, Sèrie A 47:49, 1927) contained a rich fusion of both theory and of observation. The French paper was meticulously censored when published in English: all discussions of radial velocities and distances, and the very first empirical determination of H 0 , were suppressed. Stigler's law of eponymy is yet again affirmed: no scientific discovery is named after its original discoverer (Merton, American Sociological Review 22(6):635, 1957). An appeal is made for a Lemaître Telescope naming opportunity, to honour the discoverer of the expanding universe.

Master equation with quantized atomic motion including dipole-dipole interactions

NASA Astrophysics Data System (ADS)

Damanet, François; Braun, Daniel; Martin, John

2016-05-01

We derive a markovian master equation for the internal dynamics of an ensemble of two-level atoms including all effects related to the quantization of their motion. Our equation provides a unifying picture of the consequences of recoil and indistinguishability of atoms beyond the Lamb-Dicke regime on both their dissipative and conservative dynamics, and is relevant for experiments with ultracold trapped atoms. We give general expressions for the decay rates and the dipole-dipole shifts for any motional states, and we find analytical formulas for a number of relevant states (Gaussian states, Fock states and thermal states). In particular, we show that the dipole-dipole interactions and cooperative photon emission can be modulated through the external state of motion. The effects predicted should be experimentally observable with Rydberg atoms. FD would like to thank the F.R.S.-FNRS for financial support. FD is a FRIA Grant holder of the Fonds de la Recherche Scientifique-FNRS.

Analyse de la prise en charge du nouveau-né dans le cadre de la stratégie nationale de subvention des accouchements et des soins obstétricaux et néonatals d'urgence au Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou (Burkina Faso)

PubMed Central

Ouédraogo, Solange Odile Yugbaré; Yougbaré, Nestor; Kouéta, Fla; Dao; Ouédraogo, Moussa; Lougué, Claudine; Ludovic, Kam; Traoré, Ramata Ouédraogo; Yé, Diarra

2015-01-01

Introduction Il s'agit d'analyser la prise en charge du nouveau-né dans le cadre de la stratégie na-tionale de subvention des accouchements et des soins obstétricaux et néonatals d'urgence mis en place par le gouvernement du Burkina Faso en 2006. Méthodes Nous avons menée une étude à visée descriptive et analytique comportant un volet ré-trospectif du 01 janvier 2006 au 31 décembre 2010 portant sur les paramètres épidémiologiques, cliniques des nouveau-nés hospitalisés et un volet prospectif du 3 octobre 2011 au 29 février 2012 par une entrevue des accompagnateurs des nouveau-nés et des prestataires des services de santé. Résultats Les hospitalisations ont augmenté de 43,65% entre 2006 à 2010 Le taux de mortalité néo-natale hospitalière qui était de 11,04% a connu une réduction moyenne annuelle de 3,95%. L'entrevue a porté sur 110 accompagnateurs et 76 prestataires. La majorité des prestataires (97,44%) et des ac-compagnateurs (88,18%) étaient informés de la stratégie mais n'avait pas une connaissance exacte de sa définition. Les prestataires (94,74%) ont signalé des ruptures de médicaments, consommables médicaux et des pannes d’ appareils de laboratoire et d'imagerie. Parmi les accompagnateurs (89%) disaient être satisfaits des services offerts et (72,89%) trouvaient les coûts abordables mais évoquaient les difficultés du transport. Conclusion: La subvention a amélioré la prise en charge du nou-veau-né mais son optimisation nécessiterait une meilleur information et implication de tous les acteurs. Conclusion La subvention a amélioré la prise en charge du nouveau-né mais son optimisation nécessiterait une meilleur information et implication de tous les acteurs. PMID:26161166

Large-scale Periodic Variability of the Wind of the Wolf-Rayet Star WR 1 (HD 4004)

NASA Astrophysics Data System (ADS)

Chené, A.-N.; St-Louis, N.

2010-06-01

We present the results of an intensive photometric and spectroscopic monitoring campaign of the WN4 Wolf-Rayet (WR) star WR 1 = HD 4004. Our broadband V photometry covering a timespan of 91 days shows variability with a period of P = 16.9+0.6 -0.3 days. The same period is also found in our spectral data. The light curve is non-sinusoidal with hints of a gradual change in its shape as a function of time. The photometric variations nevertheless remain coherent over several cycles and we estimate that the coherence timescale of the light curve is of the order of 60 days. The spectroscopy shows large-scale line-profile variability which can be interpreted as excess emission peaks moving from one side of the profile to the other on a timescale of several days. Although we cannot unequivocally exclude the unlikely possibility that WR 1 is a binary, we propose that the nature of the variability we have found strongly suggests that it is due to the presence in the wind of the WR star of large-scale structures, most likely corotating interaction regions (CIRs), which are predicted to arise in inherently unstable radiatively driven winds when they are perturbed at their base. We also suggest that variability observed in WR 6, WR 134, and WR 137 is of the same nature. Finally, assuming that the period of CIRs is related to the rotational period, we estimate the rotation rate of the four stars for which sufficient monitoring has been carried out, i.e., v rot = 6.5, 40, 70, and 275 km s-1 for WR 1, WR 6, WR 134, and WR 137, respectively. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de Recherche Scientifique of France, and the University of Hawaii. Also based on observations obtained at the Observatoire du Mont Mégantic with is operated by the Centre de Recherche en Astrophysique du Québec and the Observatoire de Haute-Provence which is operated by the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France.

Magnetic field structure in single late-type giants: The weak G-band giant 37 Comae from 2008 to 2011

NASA Astrophysics Data System (ADS)

Tsvetkova, S.; Petit, P.; Konstantinova-Antova, R.; Aurière, M.; Wade, G. A.; Palacios, A.; Charbonnel, C.; Drake, N. A.

2017-03-01

Aims: This work studies the magnetic activity of the late-type giant 37 Com. This star belongs to the group of weak G-band stars that present very strong carbon deficiency in their photospheres. The paper is a part of a global investigation into the properties and origin of magnetic fields in cool giants. Methods: We use spectropolarimetric data, which allows the simultaneous measurement of the longitudinal magnetic field Bl, line activity indicators (Hα, Ca II IRT, S-index) and radial velocity of the star, and consequently perform a direct comparison of their time variability. Mean Stokes V profiles are extracted using the least squares deconvolution (LSD) method. One map of the surface magnetic field of the star is reconstructed via the Zeeman Doppler imaging (ZDI) inversion technique. Results: A periodogram analysis is performed on our dataset and it reveals a rotation period of 111 days. We interpret this period to be the rotation period of 37 Com. The reconstructed magnetic map reveals that the structure of the surface magnetic field is complex and features a significant toroidal component. The time variability of the line activity indicators, radial velocity and magnetic field Bl indicates a possible evolution of the surface magnetic structures in the period from 2008 to 2011. For completeness of our study, we use customized stellar evolutionary models suited to a weak G-band star. Synthetic spectra are also calculated to confirm the peculiar abundance of 37 Com. Conclusions: We deduce that 37 Com is a 6.5 M⊙ weak G-band star located in the Hertzsprung gap, whose magnetic activity is probably due to dynamo action. Based on observations obtained at the Télescope Bernard Lyot (TBL, Pic du Midi, France) of the Midi-Pyrénées Observatory which is operated by the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France and Université de Toulouse, and at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii.

The MiMeS survey of magnetism in massive stars: CNO surface abundances of Galactic O stars

NASA Astrophysics Data System (ADS)

Martins, F.; Hervé, A.; Bouret, J.-C.; Marcolino, W.; Wade, G. A.; Neiner, C.; Alecian, E.; Grunhut, J.; Petit, V.

2015-03-01

Context. The evolution of massive stars is still partly unconstrained. Mass, metallicity, mass loss, and rotation are the main drivers of stellar evolution. Binarity and the magnetic field may also significantly affect the fate of massive stars. Aims: Our goal is to investigate the evolution of single O stars in the Galaxy. Methods: For that, we used a sample of 74 objects comprising all luminosity classes and spectral types from O4 to O9.7. We relied on optical spectroscopy obtained in the context of the MiMeS survey of massive stars. We performed spectral modelling with the code CMFGEN. We determined the surface properties of the sample stars, with special emphasis on abundances of carbon, nitrogen, and oxygen. Results: Most of our sample stars have initial masses in the range of 20 to 50 M⊙. We show that nitrogen is more enriched and carbon and oxygen are more depleted in supergiants than in dwarfs, with giants showing intermediate degrees of mixing. CNO abundances are observed in the range of values predicted by nucleosynthesis through the CNO cycle. More massive stars, within a given luminosity class, appear to be more chemically enriched than lower mass stars. We compare our results with predictions of three types of evolutionary models and show that for two sets of models, 80% of our sample can be explained by stellar evolution including rotation. The effect of magnetism on surface abundances is unconstrained. Conclusions: Our study indicates that in the 20-50 M⊙ mass range, the surface chemical abundances of most single O stars in the Galaxy are fairly well accounted for by stellar evolution of rotating stars. Based on observations obtained at 1) the Telescope Bernard Lyot (USR5026) operated by the Observatoire Midi-Pyrénées, Université de Toulouse (Paul Sabatier), Centre National de la Recherche Scientifique of France; 2) at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii; 3) at the ESO/La Silla Observatory under program ID 187.D-0917.

Relevé postnatal Rourke 2014

PubMed Central

Riverin, Bruno; Li, Patricia; Rourke, Leslie; Leduc, Denis; Rourke, James

2015-01-01

Résumé Objectif Mettre à jour la version de 2011 du Relevé postnatal Rourke (RPR) à la suite d’une révision des meilleures données probantes récentes sur le suivi de la santé des nourrissons et des enfants de la naissance jusqu’à l’âge de 5 ans. Qualité des données La qualité des données a été cotée en fonction de l’ancien système de classification du Groupe d’étude canadien sur les soins de santé préventifs (jusqu’à 2006) et l’approche de détermination, d’élaboration et d’évaluation des recommandations (GRADE). Message principal De nouveaux faits scientifiques ont été pris en compte dans les recommandations du RPR 2014 en ce qui a trait au suivi de la croissance, à la nutrition, à l’éducation et aux conseils, au développement, à l’examen physique et à l’immunisation. La croissance est surveillée à l’aide des courbes de l’Organisation mondiale de la Santé qui ont été révisées en 2014. On devrait introduire les aliments solides en fonction de l’état de préparation du nourrisson et ces produits devraient contenir du fer. Il n’est actuellement plus recommandé de retarder l’introduction des allergènes alimentaires courants pour prévenir les allergies. Il faut promouvoir l’utilisation d’une tasse sans couvercle au lieu d’une tasse à bec dès l’âge de 12 mois. La section sur l’éducation et les conseils porte sur les blessures causées par du mobilier instable, ainsi que l’utilisation d’un siège d’auto orienté vers l’arrière jusqu’à 2 ans. Elle comporte aussi de l’information sur les saines habitudes de sommeil, la prévention de la maltraitance des enfants, la vie saine et active et la sédentarité de la famille, de même que l’hygiène buccale. On a aussi ajouté à cette section une nouvelle catégorie consacrée à la santé environnementale pour tenir compte des effets des dangers environnementaux sur la santé des enfants. Le RPR a recours à une surveillance développementale globale pour reconnaître les enfants qui pourraient être à risque de retards de développement. La vérification de la mobilité de la langue et de la perméabilité de l’anus est incluse dans l’examen physique du premier bilan de santé du bébé. Le RPR présente aussi les mises à jour concernant le vaccin contre la rougeole, les oreillons et la rubéole, le vaccin atténué vivant contre la grippe et celui contre le virus du papillome humain. Conclusion Le RPR 2014 représente la mise à jour de l’outil d’application pratique des connaissances, fondé depuis longtemps sur des données probantes, accompagné de ses ressources connexes dans le web, à l’intention des professionnels de la santé et des parents pour les soins de santé préventifs durant la petite enfance. La Société canadienne de pédiatrie, le Collège des médecins de famille du Canada et Les diététistes du Canada ont donné leur aval au RPR 2014. Des versions nationales et adaptées à l’Ontario du RPR sont accessibles en français et en anglais.

Local responses to French medical imperialism in late nineteenth-century Algeria.

PubMed

Gallois, William

2007-08-01

This article offers the first account of the lives of Algerian-born doctors working in the French colonial medical service between 1870 and 1900. Their stories reveal the manner in which the idea of medical imperialism had collapsed in Algeria, as a result of maladministration, racial policies, competition between civil and military authorities, budgetary constraints and the rise of the colons. The article also indicates the way in which medicine became a locus of opposition to French rule. It shows how the first decades of the Third Republic were critical in terms of a shift from the earlier idea of medicine serving as an emblem of the mission civilisatrice to the ideological potential of medicine being seen in much more nuanced terms by both French settlers and Algerian locals. It is argued that the notion of cultural resistance to imperialism through medicine emerges in the 1870s and 1880s, thereby prefiguring the work of Fanon and the Front de Liberation Nationale's later analysis of the 'sickness' of colonial Algerian society.

Remote entanglement stabilization for modular quantum computing

NASA Astrophysics Data System (ADS)

Didier, Nicolas; Shankar, S.; Mirrahimi, M.

Quantum information processing in a modular architecture requires to distribute and stabilize entanglement in a qubit network. We present autonomous entanglement stabilization protocols between two qubits that are coupled to distant cavities. The cavities coupling is mediated and controlled via a three-wave mixing device that generates either a delocalized mode or a two-mode squeezed state between the remote cavities depending on the pump frequency. Local drives on the qubits and the cavities steer and maintain the system to the desired qubit Bell state. We show that these reservoir-engineering based protocols stabilize entanglement in presence of qubit-cavity asymmetries and losses. Most spectacularly, even a weakly-squeezed state can stabilize a maximally entangled Bell state of two distant qubits through entanglement accumulation. This research was supported by the Agence Nationale de la Recherche under Grant ANR-14-CE26-0018, by Inria's DPEI under the TAQUILLA associated team and by ARO under Grant No. W911NF-14-1-0011.

[Syphilis].

PubMed

Dupin, N

2016-11-01

Syphilis is back since the beginning of this century. The epidemic affects mainly men having sex with men with a high proportion of HIV-infected patients. The classification of syphilis distinguishes early syphilis where patients are contagious (primary, secondary and early latent of less than one year) and late syphilis where patients are not (or less) contagious (late latent of more than one year and tertiary). The clinical presentation of syphilis has not changed. However, we must insist on the early forms of neurosyphilis, notably ophthalmic syphilis often under-diagnosed, as it affects the treatment. Serologic tests may be improved but are very helpful for the positive diagnosis and the follow-up after treatment. Treatment of early syphilis is based on one injection of benzathine benzyl penicillin G. Patients who have had syphilis must be regularly followed-up after treatment, as re-infections are common and are often asymptomatic. Copyright © 2016 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Adult-onset opsoclonus-myoclonus-ataxia syndrome revealing rubella meningoencephalitis].

PubMed

Nasri, A; Mansour, M; Messelmani, M; Riahi, A; Derbali, H; Bedoui, I; Zaouali, J; Mrissa, R

2016-12-01

Opsoclonus-myoclonus-ataxia (OMS) is a rare clinical syndrome, of paraneoplastic infectious, post-infectious, post-vaccinal or idiopathic origin. We report a 24-year-old young man who presented with gait disorder preceded by a febrile rash and retroauricular lymph nodes. Three days before admission, he had headache, vertigo, nausea and vomiting followed by gait unsteadiness and movement disorders of limbs and eyes. On examination, he had OMS syndrome. Brain MRI, total body scan, MIBG scintigraphy, tumor markers and onconeural antibodies were normal. Cerebro-spinal fluid (CSF) analysis showed lymphocytic meningitis. Positive serum and CSF immunoglobulin M antibody against rubella virus was demonstrated. He received acyclovir with full recovery within two weeks. We discuss the peculiarities of this association with a literature review. This observation enlarges the spectrum of neurological manifestations of rubella as well as that of OMS etiologies. Copyright © 2016 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Enzymes for disrupting bacterial communication, an alternative to antibiotics?

PubMed

Rémy, B; Plener, L; Elias, M; Daudé, D; Chabrière, E

2016-11-01

Quorum sensing (QS) is used by bacteria to communicate and synchronize their actions according to the cell density. In this way, they produce and secrete in the surrounding environment small molecules dubbed autoinducers (AIs) that regulate the expression of certain genes. The phenotypic traits regulated by QS are diverse and include pathogenicity, biofilm formation or resistance to anti-microbial treatments. The strategy, aiming at disrupting QS, known as quorum quenching (QQ), has emerged to counteract bacterial virulence and involves QS-inhibitors (QSI) or QQ-enzymes degrading AIs. Differently from antibiotics, QQ aims at blocking cell signaling and does not alter bacterial survival. This considerably decreases the selection pressure as compared to bactericide treatments and may reduce the occurrence of resistance mechanisms. QQ-enzymes are particularly appealing as they may disrupt molecular QS-signal without entering the cell and in a catalytic way. This review covers several aspects of QQ-based medical applications and the potential subsequent emergence of resistance is discussed. Copyright © 2016 Académie Nationale de Pharmacie. All rights reserved.

[3D printed medical devices and anatomical models: What kind of distribution and which uses in French hospitals?

PubMed

Pierreville, J; Serrano, C; van den Brink, H; Prognon, P; Pineau, J; Martelli, N

2018-03-01

3D printing plays an increasingly important role in the medical sector and particularly in surgery. Nowadays, numerous manufacturers benefit from this technology to produce their medical devices and some hospitals have also purchased 3D printers. In this context, the aim of the present study was to study the distribution and the use of 3D printing in French hospitals in order to its main features in surgery. By conducting a national survey, we targeted hospitals equipped with 3D printers and those using external providers to benefit from this technology. Forty-seven hospitals were identified as using 3D printing including eight equipped with in-house 3D printers. This work gives us a first picture of 3D printing for hospital use in France and it raises questions about hospital pharmacists' involvement in 3D printed medical device production. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Combining bioinformatics, chemoinformatics and experimental approaches to design chemical probes: Applications in the field of blood coagulation.

PubMed

Villoutreix, B O

2016-07-01

Bioinformatics and chemoinformatics approaches contribute to the discovery of novel targets, chemical probes, hits, leads and medicinal drugs. A vast repertoire of computational methods has indeed been reported over the years and in this review, I will briefly introduce some concepts and approaches, namely the analysis of potential therapeutic target binding pockets, the preparation of compound collections and virtual screening. An example of application is provided for two proteins acting in the blood coagulation system. Overall, in silico methods have been shown to improve R and D productivity in both, academic settings and in the private sector, if they are integrated in a rational manner with experimental approaches. However, integration of tools and pluridisciplinarity are seldom achieved. Efforts should be done in this direction as pluridisciplinarity and a true acknowledgment of all the contributing actors along the value chain could enhance innovation and reduce skyrocketing costs. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Acute pancreatitis as the presenting feature of an IgA vasculitis: An unusual presentation].

PubMed

Fertitta, L; Noel, N; Ackermann, F; Lerolle, N; Benoist, S; Rocher, L; Lambotte, O

2017-10-01

IgA vasculitis is a systemic small vessel leukocytoclastic vasculitis characterized by skin purpura, arthritis, abdominal pain and nephritis. Most of the abdominal complications are due to edema and hemorrhage in the small bowel wall, but rarely to acute secondary pancreatitis. Here, we report a 53-year-old woman who presented with acute pancreatitis and, secondarily, developed skin purpura and arthritis at the seventh day of the clinical onset. Biological tests and computed tomographic scan allowed to rule out another cause of pancreatitis and IgA vasculitis was diagnosed as its etiology. The outcome was favorable without any relapse on glucocorticoids. Despite its rarity, pancreatitis is a potential life-threatening complication of IgA vasculitis in which the role of glucocorticoids and immunosuppressive drugs remains uncertain. A prompt elimination of other usual pancreatitis etiologies is mandatory to improve the management of the patients. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Irritable bowel syndrome: New pathophysiological hypotheses and practical issues].

PubMed

Duboc, H; Dior, M; Coffin, B

2016-08-01

In 2015, besides the fact that it still fills the gastroenterologists' offices and impairs patient's quality of life, the irritable bowel syndrome has considerably evolved on several points. The pathophysiology is now organized around a consensual hypothesis called the "brain-gut axis", which gather all the influences of peripheral factors as gut microbiota or local serotonin secretion, on the central pain perception, contributing to visceral hypersensitivity and transit modifications. About the diagnosis, the key message is "avoid over-prescription" of additional tests, and reminds that a positive clinical diagnosis based on Rome III criteria is possible after the elimination of simple clinical warning signs. Finally, the food component, a neglected and historical claim of patients, finally finds a strong scientific rational, with a diet low in fermentable sugar and polyols, that gives positive and reproducible results. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Acetaminophen induced 5-oxoproline acidosis: An uncommon case of high anion gap metabolic acidosis].

PubMed

Lanot, A; Henri, P; Nowoczyn, M; Read, M H; Maucorps, C; Sassier, M; Lobbedez, T

2018-02-01

The most common causes of high anion gap metabolic acidosis (HAGMA) are lactic acidosis, ketoacidosis, and intoxications. Nevertheless, clinicians can be faced with unexplained HAGMA, with a need to look for less common etiologies. We describe a case of 5-oxoproline (pyroglutamate) acidosis due to chronic acetaminophen ingestion at therapeutic dose in a 79-year-old inpatient. The pathophysiology of this condition is detailed, with abnormalities in the gamma-glutamyl cycle due to acetaminophen ingestion and severe chronic morbidities, resulting in glutathione and cysteine deficiency and then accumulation of 5-oxoproline. In HAGMA, when usual causes have been excluded, 5-oxoproline acidosis should be suspected in patients with chronic morbidities and acetaminophen ingestion. This diagnosis should be kept in mind because it generally resolves quickly with cessation of acetaminophen and administration of intravenous fluids. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Reactivation of parvovirus B19 infection in an HIV-infected woman].

PubMed

Sterpu, R; Ichou, H; Mahé, I; Mortier, E

2014-06-01

Infection by human parvovirus B19 (erythrovirus B19) is common and usually asymptomatic during childhood conferring lasting protection against a new infection. Parvovirus B19 infection may cause erythema infectiosum (5th disease) and aplastic crisis. Secondary symptomatic parvovirus B19 infection in the same patient is rare and its physiopathology is not always clear. A 48-year-old HIV-infected female patient presented within 5 years two acute episodes of parvovirus B19 infection although her CD4 cells count was above 500/mm(3). Absence of specific antibodies production after the first episode and persisting parvovirus viremia suggested viral reactivation rather than re-infection. During the second episode, specific antibodies were produced. Similarly to most DNA viruses, parvovirus B19 reactivation is possible in HIV-infected patients while effectively treated by antiretroviral therapy. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Cardiac sarcoidosis: Diagnosis and therapeutic challenges].

PubMed

Cohen Aubart, F; Nunes, H; Mathian, A; Haroche, J; Hié, M; Le-Thi Huong Boutin, D; Cluzel, P; Soussan, M; Waintraub, X; Fouret, P; Valeyre, D; Amoura, Z

2017-01-01

Sarcoidosis is a granulomatous disorder of unknown cause characterized by non-caseating granuloma in young adults. Cardiac involvement is rare and range from 2 to 75% depending on diagnostic criteria. Cardiac involvement in sarcoidosis may be asymptomatic or may manifest as rhythm/conduction troubles or congestive heart failure. The diagnosis and treatment of cardiac sarcoidosis may be challenging. However, advances have come in recent years from the use of cardiac MRI and 18 FDG-TEP scanner, as well as from the stratification of the risk of ventricular tachycardia/fibrillation. Due to the rarity of the disease, there is no reliable prospective large study to guide therapeutic strategy for cardiac sarcoidosis. Corticosteroids are probably efficacious, in particular in case of atrio-ventricular block or moderate heart failure. Immunosuppressive drugs have not been largely studied but methotrexate could be helpful. In refractory forms, TNF-α antagonists have been used with success. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Posterior reversible encephalopathy syndrome induced by a cough and cold drug containing pseudoephedrine].

PubMed

Ebbo, M; Benarous, L; Thomas, G; Jourde, N; Genot, S; Bernit, E; Veit, V; Harlé, J-R; Schleinitz, N

2010-06-01

Posterior reversible encephalopathy syndrome is a clinico-radiological entity characterized by neurologic symptoms in association with usually reversible bilateral posterior hemispheric oedema on neuroimaging. Many pathological conditions and treatments have been associated with this syndrome. We report a 19-year-old woman, followed-up for hypocomplementemic urticarial vasculitis, who presented with a posterior reversible encephalopathy syndrome induced by the intake of an over-the-counter cold remedy containing pseudoephedrine. Clinical manifestations and radiological abnormalities resolved after anti-hypertensive therapy and withdrawal of sympathomimetic drug. The diagnosis of posterior reversible encephalopathy syndrome should be considered in patients with compatible clinical and radiological presentation because of its potential reversibility with an appropriate management. Intake of drugs, including over-the-counter cough and cold drugs, should be looked for in the history as well as autoimmune disorders. Copyright 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

The European "clinical trial" regulation; relationship with the Jardé Act: a Giens workshop.

PubMed

Lemaire, François; Marchenay, Brigitte; Chassany, Olivier; Barthélémy, Philippe; Bouzzagou, Mohamed; Comet, Denis; Delval, Cécile; Dubray, Claude; Fouret, Cécile; Frija-Orvoen, Elisabeth; Gambotti, Laetitia; Lamarque, Véronique; d'Orsay, Geneviève; Plattner, Valérie; Sibenaler, Claire; Roux, Jacques; Thoby, Frédérique

2015-01-01

In May 2014, the European Union Parliament and Council published a new regulation on clinical trials on medicinal products for human use, which is designed to replace Directive 2001/20/EC. It will not come into effect until 2016. Nevertheless, it is essential to examine its relationship with national legislation, i.e. the Jardé Act, whose implementation has been delayed pending publication of the European regulation. The Giens workshop identified and examined the various issues that this relationship is bound to raise. In particular, it looked at trial methodology assessment procedures, the working relationship between the French National Agency of Drug Safety and Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé, ANSM) and ethics committees during the authorization application evaluation phase, review of post-authorization/registration studies on medicinal products and medical devices, and data transparency. © 2015 Société Française de Pharmacologie et de Thérapeutique.

[Retinal vasculitis and systemic diseases].

PubMed

Gascon, P; Jarrot, P-A; Matonti, F; Kaplanski, G

2018-06-19

Retinal vasculitis (RV) is an inflammation of retinal blood vessels that can be associated with uveitis or be isolated, and can induce vascular occlusion and retinal ischemia. Visual acuity can be severely affected in case of macular involvement or neovessel formation. The diagnosis relies on fundoscopy and fluorescein angiography. Systemic diseases may be associated with RV, the most frequently encountered are Behçet's disease, sarcoidosis or multiple sclerosis, all predominantly associated with venous involvement, whereas systemic lupus erythematosus and necrotizing vasculitis are less frequently observed and predominantly associated with arterial or mixed vasculitis. Treatments are usually aggressive in order to preserve a good visual acuity and to reduce retinal inflammation and chronic ischemia. Steroids, immunosuppressive drugs, retinal laser photocoagulation, intravitreal anti-VEGF injections are usual treatments and more recently, anti-TNFalpha monoclonal therapeutic antibodies have been shown to be very successful. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

French government to trim direct stake in Total

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This paper reports that the French government has decided to slash its direct stake in partly state owned oil company Total to 5% from 31.7%, a surprise move expected to raise 10 billion francs ($1.8 billion). At the same time, other state owned entities will be asked to boost their combined 2.2% stake in Total to 10%, leaving the government with a net 15% interest in Total vs. the current 34%. Initially, state owned insurance companies Groupe des Assurances Nationales and Assurances Generale de France will be asked to hike their stakes in Total, but others could be asked tomore » join if needed to meet the 10% target. The government the its phase-down of participation in Total, established in 1924 to manage French interests in Iraq Petroleum Co., was prompted by the evolution of the oil context, which differs greatly from what had prompted a significant stake of the state in Total's capital.« less

[Vertebral sarcoidosis. Spontaneous favorable outcome: A case report and literature review].

PubMed

Salmon, J-H; Perotin, J-M; Direz, G; Brochot, P; Laredo, J-D; Eschard, J-P

2013-01-01

The prevalence of vertebral sarcoidosis is highly variable (1 to 36% of reported case series). Because of limited clinical expression, its frequency is probably underestimated. Its proper management is not clearly defined. A 42-year-old woman who had a past medical history of cutaneous and pulmonary sarcoidosis presented with low back pain that was refractory to usual medical treatment. A diagnosis of vertebral localisation of sarcoidosis was considered on the history of proven sarcoidosis, radiological features, and the absence of evidence of an alternative diagnosis. In the absence of other clinical or biological evidence of active sarcoidosis, a simple follow-up was planned. MRI control at 1 year showed the resolution of vertebral sarcoidosis lesions. Spontaneous regression is a possible outcome of vertebral sarcoidosis. Initiation of a specific treatment should be discussed in the absence of other visceral involvement. Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Catheter fracture and pulmonary embolization of the distal fragment: a rare complication of the totally implantable venous access port].

PubMed

Rebahi, H; El Adib, A G; Mouaffak, Y; El Hattaoui, M; Chaara, A; Sadek, H; Khouchani, M; Mahmal, L; Younous, S

2015-01-01

Totally implantable venous access port plays a crucial role in the treatment of patients in oncology. However, its use can result sporadically in catheter fracture with catheter tip embolization into pulmonary arteries. We report this unusual but potentially serious complication in four patients. In these patients, the port had been inserted percutaneously into the subclavian vein using the infra-clavicular approach. This side effect occurred late in three patients. In all patients, the catheter fracture was asymptomatic or pauci-symptomatic and was caused by the pinch-off syndrome. The retrieval of the embolized fragments was successfully performed by transcatheter procedure in the cardiac catheterisation laboratory. We reviewed the literature and the newest guidelines and recommendations to detail the clinico-radiological features, the possible causes of this complication and discussed means to recognize, manage and prevent it. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Enterobacteriaceae producing extended spectrum beta-lactamase: epidemiology, risk factors, and prevention].

PubMed

Vodovar, D; Marcadé, G; Raskine, L; Malissin, I; Mégarbane, B

2013-11-01

Multidrug-resistant bacteria are a major worldwide health public concern. It results from the growing increase in antibiotic prescriptions, which are responsible for selection pressure on bacteria. In France like in other countries, enterobacteriaceae producing extended spectrum beta-lactamase (EESBL) are the predominant multidrug-resistant bacteria. EESBL may be responsible for severe infections and require prescription of broad-spectrum antibacterial agents. The current EESBL outbreak is different from methicillin-resistant Staphylococcus aureus outbreak that occurred in the early 1980. Consistently, EESBL are isolated both in hospital and community. Moreover, standard hygiene measures appear ineffective since EESBL prevalence is still increasing. The current inability to contain EESBL outbreak is due to several factors, including the existence of a wide community- and hospital-acquired tank of EESBL, failure to follow strict rules for hygiene, and the current irrational prescription of antibiotics. Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Science on the Fairgrounds: From Black to White Magic

NASA Astrophysics Data System (ADS)

Daniel, Raichvarg

2007-06-01

During the 18th and 19th centuries, numerous "entrepreneurs de spectacles scientifiques" — a new category of "stall-keepers" — travelled around France, displaying their scientific shows to the public. They turned out to be physics demonstrators, magicians, mechanical engineers or curators of museums of anatomy. A general survey of these shows is not easy because we have but few documents to consider. Through a various set of texts and pictures, we'll try to understand the general philosophy of these shows: the wonder, the novelty and the surprising are the key-ideas which prevail and not only the idea that these shows mostly deliver knowledge. But above all, we will see that these shows played an important part in popularizing the 19th century scientific achievement as well as achieving the 18th century goal of the Enlightenment. Finally, we may question and discuss the 21st century answer to the question of science understood as entertainment: "science'tainment" as we say: "info'tainment"!

Titanium Alloys Thin Sheet Welding with the Use of Concentrated Solar Energy

NASA Astrophysics Data System (ADS)

Pantelis, D. I.; Kazasidis, M.; Karakizis, P. N.

2017-12-01

The present study deals with the welding of titanium alloys thin sheets 1.3 mm thick, with the use of concentrated solar energy. The experimental part of the work took place at a medium size solar furnace at the installation of the Centre National de la Recherche Scientifique, at Odeillo, in Southern France, where similar and dissimilar defect-free welds of titanium Grades 4 and 6 were achieved, in the butt joint configuration. After the determination of the appropriate welding conditions, the optimum welded structures were examined and characterized microstructurally, by means of light optical microscopy, scanning electron microscopy, and microhardness testing. In addition, test pieces extracted from the weldments were tested under uniaxial tensile loading aiming to the estimation of the strength and the ductility of the joint. The analysis of the experimental results and the recorded data led to the basic concluding remarks which demonstrate increased hardness distribution inside the fusion area and severe loss of ductility, but adequate yield and tensile strength of the welds.

Plasma membrane NADH oxidase of maize roots responds to gravity and imposed centrifugal forces

NASA Technical Reports Server (NTRS)

Bacon, E.; Morre, D. J.

2001-01-01

NADH oxidase activities measured with excised roots of dark-grown maize (Zea mays) seedlings and with isolated plasma membrane vesicles from roots of dark-grown maize oscillated with a regular period length of 24 min and were inhibited by the synthetic auxin 2,4-dichlorophenoxyacetic [correction of dichorophenoxyacetic] acid. The activities also responded to orientation with respect to gravity and to imposed centrifugal forces. Turning the roots upside down resulted in stimulation of the activity with a lag of about 10 min. Returning the sections to the normal upright position resulted in a return to initial rates. The activity was stimulated reversibly to a maximum of about 2-fold with isolated plasma membrane vesicles, when subjected to centrifugal forces of 25 to 250 x g for 1 to 4 min duration. These findings are the first report of a gravity-responsive enzymatic activity of plant roots inhibited by auxin and potentially related to the gravity-induced growth response. c2001 Editions scientifiques et medicales Elsevier SAS.

Evaluation d'un scenario d'apprentissage favorisant la mobilisation des habiletes reliees au processus d'enquete

NASA Astrophysics Data System (ADS)

Blanchard, Samuel F. J.

Les resultats au Programme international pour le suivi des acquis des eleves (PISA) demontrent que les jeunes neobrunswickois francophones se classent b un niveau significativement inferieur comparaiivement aux eleves anglophones du Nouveau-Brunswick, aux eleves des autres provinces canadiennes et se classent sous la moyenne internationale de tous les pays participants quant b la culture scientifique. L'evaluation de cette culture scientifique est basee sur une serie de savoirs, de savoir-faire et de savoir-etre reliee au processus d'enquete scolaire. Le processus d'enquete scolaire est une approche b l'apprentissage ou les eleves effectuent des recherches d'informations, discutent d'idees et entreprennent des investigations pour augmenter leur comprehension d'un probleme ou d'un sujet. Les recherches demontrent que le processus d'enquete scolaire est rarement une composante pedagogique importante de la salle de classe et les recherches portant sur l'implantation du processus d'enquete scolaire recommandent de rendre ce dernier plus accessible aux enseignantes et aux enseignants. Afin de rendre le processus d'enquete plus accessible aux enseignantes et aux enseignants, notre recherche porte sur l'evaluation de la valeur pedagogique d'un scenario d'apprentissage (PhaRoboS) concu specialement pour creer un environnement dans lequel les eleves auront plusieurs occasions a mobiliser les habiletes reliees au processus d'enquete. Les retombees de cette evaluation nous permettront d'offrir des pistes de remediations afin d'aider plus d'enseignantes et d'enseignants b creer un environnement dans lequel les eleves auront plusieurs occasions b mobiliser les habiletes reliees au processus d'enquete. Cette evaluation s'est faite a partir d'une methodologie inspiree de l'evaluation pour fin d'amelioration d'un objet pedagogique. L'analyse des donnees qualitatives recueillies aupres des eleves et de leur enseignante d'une ecole francophone du Nouveau-Brunswick semble montrer que le scenario d'apprentissage a cree un environnement dans lequel les eleves ont eu plusieurs occasions b mobiliser les habiletes reliees aux processus d'enquete. Entres autres, les eleves ont emis et ont confronte des hypotheses, ont choisi des strategies de resolutions de probleme, ont communique leurs observations et ont analyse et interprete des donnees lors de leur investigation. Cependant, comme suite a cette analyse, quelques petites ameliorations seront apportees a une version subsequente du scenario d'apprentissage PhaRoboS afin de favoriser davantage la mobilisation des habiletes reliees au processus d'enquete.

Le transfert de connaissances entre les mathematiques et les sciences. Une etude exploratoire aupres d'eleves de 4e secondaire

NASA Astrophysics Data System (ADS)

Samson, Ghislain

2003-06-01

Au moment ou dans plusieurs pays on travaille a refondre les programmes d'etudes, tant au primaire qu'au secondaire, l'interet pour le transfert renait. Un des concepts fondamentaux en apprentissage consiste en l'habilete a reutiliser de facon consciente et efficace un acquis d'une situation a une autre situation. Cette recherche emane de preoccupations professionnelles au moment ou le chercheur etait enseignant au secondaire. Au cours de ces annees, il lui a ete possible de constater que plusieurs eleves percevaient difficilement les liens presents entre les disciplines mathematiques et scientifiques. Des travaux en psychologie cognitive et plus particulierement selon une perspective du traitement de l'information ont servi de cadre de reference pour evaluer et analyser les capacites de transfert aupres d'eleves de 4e secondaire. Ce cadre de reference permet de formuler le principal objectif qui est de mieux comprendre le processus de transfert chez des eleves en situation de resolution de problemes scientifiques. Cette these s'interesse donc au transfert en tant que phenomene important du processus d'apprentissage au sens de l'integration. La methode de recherche choisie, de nature qualitative, est principalement axee sur l'evaluation de la capacite a transferer des connaissances lors d'une epreuve et d'un entretien. Pour evaluer ce potentiel de transfert, nous avons elabore deux outils: une epreuve en mathematiques et en sciences et un guide d'entretien. Pour la passation de l'epreuve, le chercheur a pu compter sur la collaboration de 130 sujets provenant de deux ecoles. L'entretien complete la prise de donnees avec 13 sujets ayant accepte de poursuivre l'etude. Les donnees recueillies par ces instruments font ensuite l'objet d'une analyse de contenu. En premier lieu, les verbatims de l'epreuve et de l'entretien ont ete transcrits, puis codifies. La correction des reponses fournies pour les problemes resolus s'est faite a partir d'une grille d'analyse qualitative et adaptee de la litterature (Thouin, 1995). Une seconde serie d'analyses permettant de categoriser les reponses selon la typologie des connaissances declaratives, procedurales et conditionnelles complete la prise de donnees. Nos resultats indiquent que les sujets sont tres influences par des elements de surface, principalement lorsqu'il s'agit de problemes auxquels ils ne sont pas habitues. En l'absence de connaissances de base, plusieurs sujets vont tendre vers des propositions de solution "pratico-pratique" provenant de leur vecu: cela nous apparait d'importance d'un point de vue didactique et en matiere de transfert. Lors des entretiens realises un mois plus tard, les sujets ont eprouve de la difficulte a se rappeler le contenu de l'epreuve. Et lorsqu'il y avait un rappel, celui-ci etait superficiel et surtout axe sur le contenu ou le contexte d'un probleme. La plupart des sujets ne pouvait nommer que deux ou trois elements (des problemes en mathematiques, en sciences physiques, le probleme de la fenetre, le probleme du laser, etc.). Nos resultats confirment ce que plusieurs chercheurs (Julo, 1995, Jonnaert et Vander Borght, 1999; Richard et al., 1990) qui s'interessent aux questions de l'apprentissage admettent aujourd'hui: l'eleve ne travaille jamais sur la situation proposee par l'enseignant, mais bien sur la representation qu'il s'en est construite. Au plan methodologique, cette recherche est interessante par la variete des sources de collecte de donnees utilisees, par l'application d'outils methodologiques et d'analyses originaux tires de la recherche et de la pratique. Du cote theorique, il resulte de cette etude une meilleure comprehension du processus de transfert des connaissances mathematiques vers les sciences physiques. Finalement, aux plans didactique et pedagogique, cette recherche alimente la reflexion sur l'apprentissage et l'enseignement des sciences au secondaire. Elle fait ressortir que les mathematiques sont importantes dans la mobilisation de certaines connaissances scientifiques et que l'enseignant peut et devrait jouer un role pour favoriser le transfert.

A model for evaluating radiological impacts on organisms other than man for use in post-closure assessments of geological repositories for radioactive wastes.

PubMed

Thorn, M C; Kelly, M; Rees, J H; Sánchez-Friera, P; Calvez, M

2002-09-01

Bioaccumulation and dosimetric models have been developed that allow the computation of dose rates to a wide variety of plants and animals in the context of the deep geological disposal of solid radioactive wastes. These dose rates can be compared with the threshold dose rates at which significant deleterious effects have been observed in field and laboratory observations. This provides a general indication of whether effects on ecosystems could be observable, but does not quantify the level of those effects. To address this latter issue, two indicator organisms were identified and exposure-response relationships were developed for endpoints of potential interest (mortality in conifers and the induction of skeletal malformations in rodents irradiated in utero). The bioaccumulation, dosimetry and exposure-response models were implemented and used to evaluate the potential significance of radionuclide releases from a proposed deep geological repository for radioactive wastes in France. This evaluation was undertaken in the context of a programme of assessment studies being performed by the Agence nationale pour la gestion des déchets radioactifs (ANDRA).

Vigi4Med Scraper: A Framework for Web Forum Structured Data Extraction and Semantic Representation

PubMed Central

Audeh, Bissan; Beigbeder, Michel; Zimmermann, Antoine; Jaillon, Philippe; Bousquet, Cédric

2017-01-01

The extraction of information from social media is an essential yet complicated step for data analysis in multiple domains. In this paper, we present Vigi4Med Scraper, a generic open source framework for extracting structured data from web forums. Our framework is highly configurable; using a configuration file, the user can freely choose the data to extract from any web forum. The extracted data are anonymized and represented in a semantic structure using Resource Description Framework (RDF) graphs. This representation enables efficient manipulation by data analysis algorithms and allows the collected data to be directly linked to any existing semantic resource. To avoid server overload, an integrated proxy with caching functionality imposes a minimal delay between sequential requests. Vigi4Med Scraper represents the first step of Vigi4Med, a project to detect adverse drug reactions (ADRs) from social networks founded by the French drug safety agency Agence Nationale de Sécurité du Médicament (ANSM). Vigi4Med Scraper has successfully extracted greater than 200 gigabytes of data from the web forums of over 20 different websites. PMID:28122056

[Ocular tuberculosis : A case series].

PubMed

Koubaa, M; Smaoui, F; Gargouri, S; Ben Ayed, H; Rekik, K; Abid, I; Maaloul, I; Feki, J; Marrakchi, C; Ben Jemaa, M

2018-05-01

Ocular tuberculosis is a rare form of extra pulmonary tuberculosis. It represents 1-2% of all clinical forms. The aim of this work was to focus on diagnostic and therapeutic characteristics of ocular tuberculosis. We report a case series of 14 patients with ocular tuberculosis seen in an infectious diseases department between 2006 and 2015. The diagnosis was retained on clinical data and a positive tuberculin skin test or interferon-gamma release assay. The patient's mean age was 40.7±9years. The most common clinical presentation was uveitis (11 patients and 16 eyes). An extra ocular involvement was associated in three patients. The mean duration of antitubercular therapy was 10±2.5 months. Corticosteroid therapy was associated in 11 cases. The outcome was favorable in all cases. Two patients had maintained visual sequelae. Ocular tuberculosis is a rare disease but still remains a diagnostic problem. It should be considered in case of any chronic ocular symptoms, especially in endemic countries. Early management can improve the visual prognosis. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Pulmonary intravascular talcosis: A case report].

PubMed

Reverso-Meinietti, J; Vandenbos, F; Risso, K; Coyne, J; Leroy, S; Padovani, B; Burel-Vandenbos, F

2018-04-09

Pulmonary intravascular talcosis is a rare condition occurring in intravenous drug users injecting oral medications. Talc results in a foreign-body granulomatous reaction giving a radiological haematogenic miliary appearance mimicking miliary tuberculosis. Drug users represent a population at risk for both these conditions and their distinction may be challenging. We reported the case of a man, 33 year-old, intravenous drug addict, detected by the health services because he was the partner of a person who died of contagious and multi-resistant tuberculosis. Chest X-ray and CT scan showed a typical miliary appearance. Despite negative microbiology, clinical diagnosis of miliary tuberculosis was retained. Due to the lack of radiological improvement despite appropriate antibiotic treatment, re-evaluation and trans-bronchial biopsy were undertaken. The presence of granulomas centered by birefringent foreign bodies in polarized light led to a diagnosis of pulmonary intravascular talcosis. In the presence of pulmonary miliary in an intravenous drug addict, intravascular talcosis should be suspected. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Diagnostic issues of lymphogranuloma venereum: A case series of 5 patients].

PubMed

Fabre-Baudouin, A; Roux, A L; Marin, C; Lachatre, M; De Laroche, M; Ponsoye, M; Hanslik, T; Trad, S

2017-12-01

Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar. These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with isolated inguinal adenitis. Five men (mean age: 30±7 years) were seen in an internal medicine department, for inguinal adenopathy. One patient had clinical signs of urethritis. None presented an associated rectitis. Three patients had a history of STI, and two had a discovery of related HIV disease. Urinary polymerase chain reaction (PCR) was positive for the symptomatic patient and negative for the others. Lymph node PCR was positive in all patients within a L2b serotype (searched in 4 out of 5 cases). LG should be evoked in any patient with inguinal adenomegaly, particularly in case of STI history or risk factors. Negativity of urinary PCR should lead to further investigations, essentially a lymph node cytopuncture to evidence C. trachomatis. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Langerhans cell histiocytosis in adults].

PubMed

Néel, A; Artifoni, M; Donadieu, J; Lorillon, G; Hamidou, M; Tazi, A

2015-10-01

Langerhans cell histiocytosis (LCH) is a rare disease characterized by the infiltration of one or more organs by Langerhans cell-like dendritic cells, most often organized in granulomas. The disease has been initially described in children. The clinical picture of LCH is highly variable. Bone, skin, pituitary gland, lung, central nervous system, lymphoid organs are the main organs involved whereas liver and intestinal tract localizations are less frequently encountered. LCH course ranges from a fulminant multisystem disease to spontaneous resolution. Several randomized controlled trials have enable pediatricians to refine the management of children with LCH. Adult LCH has some specific features and poses distinct therapeutic challenges, knowing that data on these patients are limited. Herein, we will provide an overview of current knowledge regarding adult LCH and its management. We will also discuss recent advances in the understanding of the disease, (i.e. the role of BRAF oncogene) that opens the way toward targeted therapies. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Rapport sur l'état du patrimoine astronomique dans les observatoires français de la fin du XIXè siècle

NASA Astrophysics Data System (ADS)

Damm, E.; Pécontal, E.

2012-12-01

Suite au colloque sur la sauvegarde du patrimoine astronomique organisé par le MAEE et la SAF, sous l'égide de l'UNESCO, qui a conduit à l'adoption de la Déclaration de Paris, les directeurs d'observatoires institutionnels qui étaient absents du colloque ont ressenti le besoin de discuter de ces conclusions prises en leur nom. L'initiative d'organiser une réunion des directeurs des Observatoires des Sciences de l'Univers (OSU) à ce sujet le 30 janvier 2012 a été prise par François Vernotte, directeur de l'Observatoire de Besançon. Le présent compte-rendu de visite résulte d'une initiative spontanée d'Emmanuel Pécontal, astronome responsable du Patrimoine à l'observatoire de Lyon, et d'Evelyne Damm, membre de la Commission Nationale de classement des Monuments Historiques (CNMH) et élue à la communauté d'agglomération des Portes de l'Essonne oû est sis l'observatoire de Camille Flammarion.

[Carbapenemase-producing enterobacteriae: epidemiology, strategies to control their spread and issues].

PubMed

Lepelletier, D; Batard, E; Berthelot, P; Zahar, J-R; Lucet, J-C; Fournier, S; Jarlier, V; Grandbastien, B

2015-07-01

The increasing bacterial resistance to antibiotics has become a major public health concern bringing the threat of therapeutic impasses. In this context, control of the spread of highly-resistant bacteria emerging antibiotics (BHRe), such as glycopeptide-resistant enterococci (VRE) and Enterobacteriaceae producing carbapenemases (CPE), is based on a dual strategy of reducing the prescription of antibiotics to limit the pressure selection and preventing the spread from carriers. Prevention strategy is based on three different levels such as standard precautions for all patients with a particular focus on the management of excreta, and additional precautions for BHRe carriers. What makes it difficult is that carriage is usually completely asymptomatic, enterobacteria and enterococci are normal commensal of gut microbiota. Explosive dissemination of Enterobacteriaceae producing extended spectrum beta-lactamases in hospital and community heralds the emergence of CPE whose import by patients with a history of hospitalization in abroad may be the main source of spread in France. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Five cases of acute Zika virus infection in French women of reproductive age returning from Central and South America.

PubMed

Penot, P; Balavoine, S; Leplatois, A; Brichler, S; Leparc-Goffart, I; Alloui, A-C; Flusin, O; Guilleminot, J; Amellou, M; Molina, J-M

2017-08-01

The favorable season for Aedes albopictus circulation has started in Europe and may lead to autochthonous transmission of Zika virus. Health care providers should be familiar with evocative clinical presentations and able to give updated information to women of reproductive age infected by Zika virus. We report five laboratory-confirmed Zika virus infections imported to metropolitan France from Central and South America between January and April, 2016. The five young women were not connected and not pregnant; common presentation combined a rash with persistent arthralgia. Zika virus was identified by RT-PCR from serum or urines, between two and eight days after the onset of the symptoms. As the duration of potential materno-foetal infectivity is still unknown, we were unable to answer with certitude to the patients' questions about the time interval to respect before attempting a pregnancy: one of them became pregnant one month after the diagnosis. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Splenic abscesses: From diagnosis to therapy].

PubMed

Davido, B; Dinh, A; Rouveix, E; Crenn, P; Hanslik, T; Salomon, J

2017-09-01

Splenic abscess is septic collection which occurs after haematogenous spread or local dissemination. Splenic abscess is an uncommon and rare condition, more frequently affecting male and immunocompromised patients. There are no guidelines regarding its diagnosis and management. Computed tomography (CT) scan is highly sensitive and specific (95% and 92%, respectively) in the diagnosis of splenic abscess. Diagnosis is based on blood cultures which are positive in 24 to 80% of cases. Bacterial growth culture of abscess after drainage is more efficient (50-80%) and can be performed after surgery or percutaneous drainage under imaging, including CT scan. Microorganisms involved are frequently enterobacteriaceae, gram-positive cocci and anaerobes. This particular ecology leads to an empiric broad-spectrum antibiotic therapy, with a variable duration, from 10days to more than one month. Management remains very close to the one applied in case of liver abscesses. The role of splenectomy in the prevention of recurrence remains controversial. We reviewed the literature regarding splenic abscesses, from diagnosis to therapy. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

The New Microbiology: a conference at the Institut de France.

PubMed

Radoshevich, Lilliana; Bierne, Hélène; Ribet, David; Cossart, Pascale

2012-08-01

In May 2012, three European Academies held a conference on the present and future of microbiology. The conference, entitled "The New Microbiology", was a joint effort of the French Académie des sciences, of the German National Academy of Sciences Leopoldina and of the British Royal Society. The organizers - Pascale Cossart and Philippe Sansonetti from the "Académie des sciences", David Holden and Richard Moxon from the "Royal Society", and Jörg Hacker and Jürgen Hesseman from the "Leopoldina Nationale Akademie der Wissenschaften" - wanted to highlight the current renaissance in the field of microbiology mostly due to the advent of technological developments and allowing for single-cell analysis, rapid and inexpensive genome-wide comparisons, sophisticated microscopy and quantitative large-scale studies of RNA regulation and proteomics. The conference took place in the historical Palais de l'Institut de France in Paris with the strong support of Jean-François Bach, Secrétaire Perpétuel of the Académie des sciences. Copyright © 2012 Académie des sciences. Published by Elsevier SAS. All rights reserved.

[Treatment of Behçet's disease].

PubMed

Comarmond, C; Wechsler, B; Cacoub, P; Saadoun, D

2014-02-01

Behçet's disease (BD) is a systemic large-vessel vasculitis characterized by a wide clinical spectrum including recurrent oral and genital ulcerations, uveitis, vascular, neurological, articular, and gastrointestinal manifestations. Therapeutic management of BD depends on the clinical presentation and organ involved. Although colchicine, non-steroidal anti-inflammatory agents and topical treatments with corticosteroids are often sufficient for mucocutaneous and joint involvement, a more aggressive approach with immunosuppressive agents is warranted for severe manifestations such as posterior uveitis, retinal vasculitis, vascular, neurological and gastrointestinal involvement. However, some patients still have refractory disease, relapses, sight threatening eye disease, or irreversible organ damage. Recent improvements in the understanding of the pathogenic mechanisms have led to the identification of potential targets and future therapies for BD. In contrast to current non-specific immunosuppressive agents, the emergence of immunomodulatory drugs provides the possibility of interfering with specific pathogenic pathways. Novel targeted immunosuppressive therapies might be used in the future for BD. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Ischemic strokes in young adults and illegal drugs].

PubMed

Barbieux, M; Véran, O; Detante, O

2012-01-01

One out of four ischemic strokes in France occurs in adults under 65 years old. About a third of them remain unexplained even after an extensive etiological assessment. A large part of these unexplained strokes could be linked to illegal drug abuse, and 10 % are estimated to be directly linked to illegal drugs in some international studies. The most frequently incriminated recreational drug remains cocaine, via several mechanisms. However, several other illegal drugs, some very commonly used such as cannabis, are suspected to have an important role in neurovascular diseases. In this article, we reviewed the epidemiological, pathophysiological and clinical studies, published in the international literature over the past 30 years. The drug-caused stroke epidemiology needs to be more precisely studied, as well as the underlying mechanisms depending on each drug. This is a public health issue that affects an economically active population, as stroke is the first cause of acquired handicap in adults. Copyright © 2011 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Alzheimer's disease cerebro-spinal fluid biomarkers: A clinical research tool sometimes useful in daily clinical practice of memory clinics for the diagnosis of complex cases].

PubMed

Magnin, E; Dumurgier, J; Bouaziz-Amar, E; Bombois, S; Wallon, D; Gabelle, A; Lehmann, S; Blanc, F; Bousiges, O; Hannequin, D; Jung, B; Miguet-Alfonsi, C; Quillard, M; Pasquier, F; Peoc'h, K; Laplanche, J-L; Hugon, J; Paquet, C

2017-04-01

The role of biomarkers in clinical research was recently highlighted in the new criteria for the diagnosis of Alzheimer's disease. Cerebro-spinal fluid (CSF) biomarkers (total Tau protein, threonine 181 phosphorylated Tau protein and amyloid Aβ1-42 peptide) are associated with cerebral neuropathological lesions observed in Alzheimer's disease (neuronal death, neurofibrillary tangle with abnormal Tau deposits and amyloid plaque). Aβ1-40 amyloid peptide dosage helps to interpret Aβ1-42 results. As suggested in the latest international criteria and the French HAS (Haute Autorité de santé) recommendations, using theses CSF biomarkers should not be systematic but sometimes could be performed to improve confidence about the diagnostic of Alzheimer's disease in young subjects or in complex clinical situations. Future biomarkers actually in development will additionally help in diagnostic process (differential diagnosis) and in prognostic evaluation of neurodegenerative diseases. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Technical and design update in the AUBE French low-level radioactive waste disposal facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marque, Y.

1989-01-01

Long-term industrial management of radioactive waste in France is carried out by the Agence Nationale pour la Gestion des Dechets Radioactifs (ANDRA). ANDRA is in charge of design, siting, construction, and operation of disposal centers. The solution selected in France for the disposal of low- and medium-level, short-lived radioactive waste is near-surface disposal in the earth using the principle of multiple barriers, in accordance with national safety rules and regulations, and based on operating experience from the Centre de Stockage de la Manche. Since the center's start-up in 1969, 400,000 m{sup 3} of waste have been disposed of. The Frenchmore » national program for waste management is proceeding with the construction of a second near-surface disposal, which is expected to be operational in 1991. It is located in the department of AUBE (from which its name derives), 100 miles southeast of Paris. The paper describes the criteria for siting and design of the AUBE disposal facility, design of the AUBE facility disposal module, and comparison with North Carolina and Pennsylvania disposal facility designs.« less

[Telemedicine in thrombotic microangiopathies: A way forward in rare diseases requiring emergency care].

PubMed

Coppo, P; Corre, E; Rondeau, E; Benhamou, Y; Bachet, A; Stépanian, A; Veyradier, A

2016-08-01

Thrombotic microangiopathies (TMA) represent rare diseases requiring a high skill for their management that deserved in France the identification of a dedicated National reference center. TMA are short-term life-threatening diseases; however, with an adapted management, their prognosis can be excellent. It is therefore mandatory to recognize and treat them rapidly according to standard guidelines. Telemedicine is a specialized hub consisting of highly skilled staff trained in a specific domain of medicine. The telemedicine activity of a reference center is an important representative indicator of its expertise and recourse ability. It requires to be accurately evaluated and promoted. In this work, we report the French reference center for TMA telemedicine activity since its setting-up. TMA represent an interesting model of diseases that required a specific organization of telemedicine activity to adapt to clinicians demand, which includes particularly the need to answer resorts in real time 24/7. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Security of the medicinal therapy: Cartography of risks a priori within service of orthopaedic surgery].

PubMed

Razurel, A; Bertrand, É; Deranlot, J; Benhamou, F; Tritz, T; Le Mercier, F; Hardy, P

2015-11-01

Security and quality of the Medicinal Therapy are one of the most important objectives of the April 6th, 2011 order. The objective is to realize this study of the risks incurred by patients related to management and security of medicinal therapy in order to establish a plan to reduce the risks of drug's dispensation. The method of the Preliminary Risk Analysis (PRA) has been implemented by a multidisciplinary group in a hospital service of orthopaedic surgery. The study focused on the dispensation phase of medicinal circuit. This analysis revealed 148 scenarii, 35 were criticality unacceptable. Fifty-four initial risk control actions were proposed and their stress levels to put them in place were evaluated. The main measures of risk management are: training, information, communication, computerization, automation, dual control, updating the documentation system, drug reconciliation and respect for Best Practices Hospitallers (BPH). Risk management requires a significant human and financial investment as well as, material resources and multidisciplinary expertise in order to offer the best solutions. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Jean Francheteau (1943-2010)

NASA Astrophysics Data System (ADS)

Sclater, John; Le Pichon, Xavier

2010-12-01

Jean Francheteau, pioneering marine geologist and geophysicist, AGU Fellow, and emeritus professor at the University of Brest (Université de Bretagne Occidentale), died on 21 July in St-Renan, Brittany, France, at the age of 67 after a long illness. With his passing, the field of Earth sciences lost a major contributor to the development of a definitive theory of plate tectonics and one of the first to make visual geological observations on the deep seafloor. Such scientific accomplishments, coupled with his personal charm and the ability to collaborate with researchers from many institutions, ensured that he had a huge influence not only on the world of research but also on teaching and the application of ethics to science. Jean arrived at Scripps Institution of Oceanography in La Jolla, Calif., in 1966 after obtaining a diploma in mining engineering at the prestigious Éole Nationale Supérieure de la Métallurgie et de l'Industrie des Mines in Nancy, France. He chose Victor Vacquier as his thesis supervisor and began working in Vic's lab with John Sclater, ostensibly on heat flow measurements.

[A complex case of diabetes due to LMNA mutation].

PubMed

Ambonville, C; Bouldouyre, M-A; Laforêt, P; Richard, P; Benveniste, O; Vigouroux, C

2017-10-01

Laminopathies (diseases related to A/C mutations of lamines) are rare genetic diseases with an extensive phenotypic spectrum, including lipodystrophic syndromes-characterized by a selective loss of adipose tissue-of which the partial Dunnigan family type is the most frequent. We report on a 55-year-old woman with diabetes and long-term disabling myalgia. Her cushingoid morphotype, associated with cutaneous lipo-atrophy and muscle hypertrophy in addition to a genetic heritage, led us to the diagnosis of complex partial familial lipodystrophy heterozygous LMNA_c.82C>T, p.Arg28Trp mutation. Familial partial lipodystrophic syndromes may have varied phenotypes, mainly cardio-metabolic, which could mimic a particularly severe type 2 diabetes. The diagnostic work-up of this disease has to include a careful investigation of gait troubles and paroxysmal conduction that could lead to sudden death, as well as a genetic examination. In some cases, recombinant leptin can be proposed. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Galaxy Population Properties in the Rich Clusters MS 0839.8+2938, MS 1224.7+2007, and MS 1231.3+1542

NASA Astrophysics Data System (ADS)

Hutchings, J. B.; Edwards, L.

2000-03-01

This paper discusses the galaxy populations of three rich clusters, with redshifts 0.19 (0839+29), 0.24 (1231+15), and 0.32 (1224+20), from the database of the CNOC1 consortium. The data consist of spectra of 52 cluster members for 0839+29, 30 members for 1224+15, and 82 members for 1231+15, and there are comparable numbers of field galaxy spectra. Cluster 0839+29 is compact with no strong radial gradients, and possibly dusty. Cluster 1224+20 is isolated in redshift and has low velocity dispersion around the cD galaxy and low 4000 Å break. Cluster 1231+15 is asymmetric, and we discuss the possibility that it may be a recent merger of two old clusters. We find few galaxies in 0839+29 and 1231+15 with ongoing or recently truncated star formation. Based on observations with the Canada-France-Hawaii-Telescope, which is operated by the National Research Council of Canada, the Centre National de la Recherche Scientifique of France, and the University of Hawaii.

L'opération de la Carte du Ciel dans les contextes institutionnel et technique de l'astronomie française à la fin du XIXe siècle

NASA Astrophysics Data System (ADS)

Le Guet Tully, F.; Sadsaoud, H.; de La Noë, J.

2008-06-01

Ce chapitre analyse le contexte institutionnel français dans lequel naît la Carte du Ciel. Dans les années 1880, le régime républicain réorganise totalement la recherche astronomique. À Paris, l'instrumentation est totalement renouvelée sous l'impulsion de Maurice Loewy. En province, les efforts de décentralisation permettent un accroissement significatif des arsenaux techniques de Marseille et Toulouse, ainsi que l'édification des établissements de Besançon, Lyon et Bordeaux. À Alger, la station astronomique créée sous le second Empire est transformée en un observatoire particulièrement dynamique grâce à l'implication de Charles Trépied. Ce panorama des établissements astronomiques permet de cerner les enjeux institutionnels et scientifiques qui concourent à l'engagement des observatoires de Paris, Bordeaux, Toulouse et Alger dans l'entreprise de la Carte du Ciel.

"De Cassini à l'an 2000": The Paris Observatory Library

NASA Astrophysics Data System (ADS)

Vallet, M.; Reymonet, N.

Paris Observatory founded in 1667 by Louis XIV is one of the so called "Grand Etablissement" under of the aegis of the Ministry of higher education and research, and includes two other centres: Meudon Observatory and the Radioastronomy centre in Nancay, created respectively in 1876 and 1955. The decree which gave birth to the library itself was signed in 1785 by Louis XVI. In 1926 Meudon is joined to Paris. The total number of bound volumes, including journals, is 100.000. This comprises 2000 periodical titles (of which 1200 are current titles), monographs, photographs, incunabula and manuscripts from the 16th to the 20th century, microfilm versions of historical material. The collections of two libraries are complementary. Starting in 1981, the library became part of a national "Centre d'Acquisition et de Diffusion de l'Information Scientifique et Technique" (CADIST) for astronomy and astrophysics documents. The catalogue is available on national networks such as the Pancatalogue or CCN. It may also be accessed on the international OCLC network. Finally the library may be accessed on internet via WWW.

[Charles Gerhardt's life and work].

PubMed

Blondel-Mégrelis, Marika

2008-05-01

Charles Gerhardt's life and work is rather well-known thanks to Grimaux and Tiffeneau. His reform of the equivalents, his classification, his obtention of organic acid anhydrids and his famous Treatise of Organic Chemistry. His active collaboration to the Revue scientifique et industrielle du Docteur Quesneville, the creation of his Comptes-Rendus des Travaux de Chimie. Are not so often quoted. Thanks to his translations and reviews, German chemical advancements became well known in France Gerhardt was Liebig's translator for almost all his life, even through the fluctuations of their personal relation. He was the representative of German chemistry in France. With Auguste Laurent, with whom he is constantly associated, things need to be examined precisely. Laurent and Gerhardt, friends at a moment, cannot be confounded. Though they worked together for some years, they were not engaged in a similar project. Besides an experimentalist, Laurent was essentially a theorician of chemistry, whereas Gerhardt refused to think about atoms and arrangements. Formulas have to describe relations between facts, in no case anything about arrangements. For posterity however, Gerhardt will be, on the same level as Laurent, the creator of modern chemistry doctrines.

Meeting IYA Goals for Diverse Planetarium and Science Museum Audiences

NASA Astrophysics Data System (ADS)

Nichols, M. M.; Carney, K. E.

2008-11-01

The International Year of Astronomy (IYA) in 2009 provides the Adler Planetarium in Chicago, Illinois with a chance to bring astronomy into the city of Chicago and beyond. The Adler serves diverse audiences in the Chicagoland area and elsewhere. Each audience has unique needs to be taken into account when designing for IYA. The Adler has created a suite of programs for IYA that addresses a number of topical strands, tailored for the many audiences that Adler serves. Adler has found synergy between some existing programs designed for these audiences and IYA thematic strands. One advantage of this is that it increases the likelihood of program sustainability. The authors will outline some of Adler's program plans to date from person-to-person community outreach programs such as Café Scientifique programs, to a citizen science light pollution observation program, to programs within the institution, such as a new temporary exhibit about the roles of telescopes in our understanding of the cosmos. The presenters will focus on the range of programming and how they bring together IYA topics as well as addressing the needs of our identified audiences.

Le sevrage de l’allaitement

PubMed Central

Grueger, Barbara

2013-01-01

RÉSUMÉ L’allaitement exclusif assure une alimentation optimale aux nourrissons jusqu’à l’âge de six mois. Par la suite, les nourrissons ont besoin d’aliments complémentaires pour répondre à leurs besoins nutritionnels. C’est alors que le sevrage commence. Le sevrage désigne le processus graduel d’introduction d’aliments complémentaires au régime du nourrisson, tout en poursuivant l’allaitement. Il n’y a pas de moment universellement accepté ou scientifiquement démontré pour mettre un terme à l’allaitement. Le moment et le processus de sevrage doivent être adaptés par la mère et l’enfant. Le sevrage peut être soudain ou graduel, prendre plusieurs semaines ou plusieurs mois, être dirigé par l’enfant ou par la mère. Les médecins doivent orienter et soutenir les mères tout au long du processus de sevrage. Le présent document remplace le document de principes sur le sevrage qu’a publié la Société canadienne de pédiatrie en 2004.

A Precise Measurement of the Deuteron Elastic Structure Function A(Q 2)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Honegger, Andrian

1999-12-07

During summer 1997 experiment 394-018 measured the deuteron tensor polarization in D(e,e'more » $$vec\\{d}$$) scattering in Hall C at Jefferson Laboratory. In a momentum transfer range between 0.66 and 1.8 (GeV=c) 2, with slight changes in the experimental setup, the collaboration performed six precision measurements of the deuteron structure function A(Q 2) in elastic D(e,e'd) scattering . Scattered electrons and recoil deuterons were detected in coincidence in the High Momentum Spectrometer and the recoil polarimeter POLDER, respectively. At every kinematics H(e,e') data were taken to study systematic effects of the measurement. These new precise measurements resolve discrepancies between older data sets and put significant constraints on existing models of the deuteron electromagnetic structure. This work was supported by the Swiss National Science Foundation, the French Centre National de la Recherche Scientifique and the Commissariat 'a l'Energie Atomique, the U.S. Department of Energy and the National Science Foundation and the K.C. Wong Foundation.« less

Patrick Couvreur: inspiring pharmaceutical innovation.

PubMed

Stanwix, Hannah

2014-05-01

Patrick Couvreur speaks to Hannah Stanwix, Managing Comissioning Editor: Professor Patrick Couvreur received his pharmacy degree from the Université Catholique de Louvain (Louvain-la-Neuve, Belgium) in 1972. He holds a PhD in pharmaceutical technology from the same university and completed a postdoctoral fellowship at the Eidgenössische Technische Hochschule (Zürich, Switzerland). Since 1984, Professor Couvreur has been Full Professor of Pharmacy at the Paris-Sud University (Paris, France) and was holder of the Chair of Innovation Technologique at the prestigious Collège de France (Paris, France). He has published more than 450 peer-reviewed articles and has an H-index of 73, with over 19,000 citations. Professor Coureur has been recognized by numerous national and international awards, including the 2004 Pharmaceutical Sciences World Congress Award, the prestigious Host Madsen Medal, the Prix Galien, the European Pharmaceutical Scientist Award 2011 from the European Federation of Pharmaceutical Sciences, the Médaille de l'Innovation from the Centre National de la Recherche Scientifique, and recently the European Inventor Award 2013 from the European Patent Office.

[Typology of the French medical learned societies. Survey of 129 organizations].

PubMed

Maisonneuve, Hervé; Moreau, Nicolas; Steudler, François; Guérot, Claude; Durocher, Alain

2004-07-10

A study on the relationship between the ANDEM--Agence Nationale pour le Développement de l'Evaluation Médicale (French agency for the development of health technology assessment) and the learned societies showed that a definition of the role of these organisations and criteria to define learned societies were lacking. We conducted a survey among the learned societies in the field of medicine so as to elaborate a definition. We used the files of the learned societies of the Anaes--Agence Nationale d'Accréditation et d'Evaluation en Santé (French Agency for accreditation and evaluation in health) in 1998, which included 225 organisations. We sent a letter together with a single-page questionnaire and copies of the 2 publications on the relationship between the ANDEM and the learned societies. To analyse the suggestions for a definition, having read the replies, a segmentation of the population, the means and modalities of action and the aims and fields of action were used. A proposal for a definition was discussed during 2002/2003 with the board of the Fédération des Spécialités Médicales (FSM) (Federation of medical specialties) regrouping 33 medical and 12 surgical societies. Three meetings between a representative of the Anaes and the board of the FSM resulted in the proposition of so-called "validation" criteria for learned societies. A search on the French Internet listing such societies was made using a research motor (March 20, 2004). Out of the 225 organisations contacted, 129 (57%) replied. Among the latter, 115 considered themselves as a learned society and 14 did not. Among the 115 organisations defining themselves as a learned society, 97 proposed a definition, 16 made use of the definitions proposed in the questionnaire and 81 proposed their own definition. The analysis identified 6 important elements (reporting, knowledge, education, research, diffusion, promotion). The data analysed permitted the elaboration of a definition based on the proposals of the learned societies: "An organised group, within the framework of a given discipline, the members' aim of which is to report on their work, to improve knowledge on their discipline, to ensure education and research, to diffuse information on their work and research and to support and promote their discipline". Thirty-two of the 45 societies of the FSM accepted the 11 validation criteria proposed, some of which were commented on. Only one society abstained and 12 did not reply. No French Internet web site listing the learned societies specified a definition of criteria for inclusion in the lists. A definition of the learned societies and validation criteria, obtained through the participation of the principle actors, could serve as a basis for the recognition and identification of such societies.

Préface

NASA Astrophysics Data System (ADS)

Hamieh, Tayssir

2005-05-01

Né simultanément à Mulhouse et à Beyrouth en 1996 dans le cadre d'une collaboraiion franco-libanaise sur une initiative personnelle de Monsieur Tayssir HAMIEH. le Colloque Franco-Libanais sur la Science des Matériaux (CSM), qui s'inscrit dans le cadre des relations étroites entre la France et le Liban, est très vite devenu une occasion très importante de rencontre entre scientifiques de haut niveau, non seulement, du contour méditerranéen mais également des pays européens, américains et arabes. La quatrieme édition CSM4 est une véritable réussite grâce à la participation des chercheurs confirmés dans tous les domaines des sciences de matériaux et venant de plusieurs pays tels que la France, I'Algérie, Le Liban, la Syrie, le Maroc, la Tunisie, l'Italie, l'Espagne, le Portugal, le Royaume Uni, les États-Unis, la Russie, l'Allemagne, le Japon et I'Inde ; pour présenter plus de 350 communications orales et par affiche et couvrant presque toutes les disciplines des systèmes des matériaux. Le choix des diffèrents thèmes du colloque sur la science des matériaux a été dicté par l'importance capitale de cette discipline dans notre civilisation moderne. En fait, les matériaux utilisés pour la fabrication artisanale ou industrielle d'objets, de produits et de systèmes ainsi que pour la réalisation de constructions et d'équipements ont de tout temps défini le niveau de notre civilisation technique. La réalisation des objectifs communs de notre monde en plein développement, pour ne pas dire en pleine mutation, est en grande partie tributaire de la mise au point de nouveaux matériaux et de procédés de transformation et d'assemblages nouveaux, présentant des performances et des qualités améliorées. Le colloque a illustré et traduit, de manière remarquables, l'excellente collaboration entre chercheurs libanais et français. Le partenariat est exemplaire par la qualité des laboratoires impliqués et par le niveau scientifique des résultats. Nous souhaitons que ce colloque franco-libanais sur la science des matériaux continue son succès implacable et incontournable et oeuvre pour une collaboration fructueuse entre les chercheurs des deux pays et les autres chercheurs des pays arabes et francophones. Coordinateur et Éditeur du Colloque Tayssir HAMIEH

Eco-hydrology: Groundwater flow and site factors in plant ecology

NASA Astrophysics Data System (ADS)

Klijn, Frans; Witte, Jan-Philip M.

Résumé En écologie végétale, le site est un concept central. Un site, c'est l'endroit où une espèce végétale ou une communauté de plantes se développe le site assure un ensemble de conditions dans lesquelles elles vivent. Dans un matériau homogène à l'origine, l'écoulement gravitaire d'une nappe influence les conditions du site par l'intermédiaire de la distribution spatiale des nutriments et d'autres composés chimiques associés. Les remontées d'eau peuvent tout spécialement produire et maintenir les conditions du site essentielles pour différentes espèces et communautés de plantes relativement rares. Les écologues ont porté une attention accrue à ces remontées d'eau, en sorte qu'une coopération avec les hydrologues en a résulté, avec l'émergence d'une discipline propre, l'éco-hydrologie, à la limite des deux domaines scientifiques et liée au concept de site. Aux Pays-Bas, une classification des types d'eau, basée sur l'histoire de l'eau souterraine à proximité de la surface, a été mise en oeuvre pour constituer une base nationale de données géographiques sur les remontées d'eau d'intérêt écologique. Des analyses des correspondances des données de cette base, portant sur l'existence de certaines espèces de plantes, montrent que dans les sols sableux pauvres du Pléistocène la remontée d'eau explique très bien la présence de certaines espèces et communautés, alors que, dans les plaines fluviales et les régions de polders à sols argileux riches, l'influence de la remontée d'eau est masquée par l'importance des caractéristiques des sols. En conclusion donc, certaines espèces de plantes peuvent être utilisées comme des indicateurs de la remontée d'eau dans des diagnostiques et des levés de terrain rapides, mais à condition de prendre en permanence des précautions sur les limites de l'approche. Resumen En ecología botánica un concepto de gran importancia es el de emplazamiento, definido como el lugar que proporciona unas condiciones de vida adecuadas que permiten el crecimiento de una especie o una comunidad botánica. En un material inicialmente homogéneo, el flujo subterráneo gravífico influencia las condiciones del emplazamiento variando la distribución espacial de los nutrientes y de otros agentes químicos relevantes. En especial, el flujo ascendente puede producir y mantener una serie de condiciones que son esenciales para algunas especies y comunidades de plantas relativamente raras. La especial atención hacia este fenómeno ha dado lugar a una cooperación entre ecologistas e hidrogeólogos y a la aparición de una nueva disciplina - eco-hidrología -, en la frontera de los dos campos científicos. En Holanda, se ha usado una clasificación sencilla de tipos de agua para crear una base de datos, a nivel nacional, de lugares donde la presencia de flujos ascendentes pueda ser de interés ecológico. El análisis de correspondencias entre esta base de datos y los tipos de plantas existentes muestra que en los suelos arenosos pobres del Pleistoceno los flujos ascendentes explican la presencia de algunas especies y comunidades de plantas. Por el contrario, en las llanuras fluviales y pólders, con suelos más arcillosos, la influencia de estos flujos es despreciable frente a la relativa a las propias características de los suelos. Se concluye que las especies botánicas se pueden usar como indicadores de la presencia de flujo ascendente sólo en campañas preliminares, pero que el método presenta grandes limitaciones para su extensión a casos generales.

Ensemble Classifiers for Predicting HIV-1 Resistance from Three Rule-Based Genotypic Resistance Interpretation Systems.

PubMed

Raposo, Letícia M; Nobre, Flavio F

2017-08-30

Resistance to antiretrovirals (ARVs) is a major problem faced by HIV-infected individuals. Different rule-based algorithms were developed to infer HIV-1 susceptibility to antiretrovirals from genotypic data. However, there is discordance between them, resulting in difficulties for clinical decisions about which treatment to use. Here, we developed ensemble classifiers integrating three interpretation algorithms: Agence Nationale de Recherche sur le SIDA (ANRS), Rega, and the genotypic resistance interpretation system from Stanford HIV Drug Resistance Database (HIVdb). Three approaches were applied to develop a classifier with a single resistance profile: stacked generalization, a simple plurality vote scheme and the selection of the interpretation system with the best performance. The strategies were compared with the Friedman's test and the performance of the classifiers was evaluated using the F-measure, sensitivity and specificity values. We found that the three strategies had similar performances for the selected antiretrovirals. For some cases, the stacking technique with naïve Bayes as the learning algorithm showed a statistically superior F-measure. This study demonstrates that ensemble classifiers can be an alternative tool for clinical decision-making since they provide a single resistance profile from the most commonly used resistance interpretation systems.

[Management of neuropathic pain].

PubMed

Lozeron, P; Kubis, N

2015-07-01

Neuropathic pain is often underestimated and not adequately treated. The DN4 scale is very useful for its identification since it will benefit from pharmacological and non-pharmacological specific alternative care. The pathophysiological mechanisms involve the hyperexcitability of nociceptive pathways or decreased inhibitory descending controls that will be the target of pharmacological treatments. Frontline molecules are antidepressants (tricyclics and mixed serotonin and norepinephrine reuptake inhibitors) and antiepileptics (α2δ calcium channel inhibitors). However, these drugs will only have a partial efficacy on pain. The therapeutic strategy is based on reasonable goals, starting with a monotherapy adapted to the patient's symptoms and comorbidities and increased step by step. Patient compliance to contract is essential and requires clear and complete information. The impact on profession, social and family integration should rapidly be taken into account. In case of inefficiency, a change of the first-line treatment or an association could be considered. Some indications justify a specific therapy. Patients with resistant chronic pain should be sent to a specialized centre. New drugs are being studied and non-pharmacological support must be evaluated. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[The French medecine pricing committee].

PubMed

Giorgi, D

2017-09-01

The French medicine pricing committee (CEPS) has to reconcile several major constraints, including optimal patient access to medicines and a good control of expenditures on reimbursable medicines. From 2013 to 2015, drug price decreases and discounts obtained by CEPS contributed more than € 5 billion to the balance of the health insurance accounts. As for price setting, there is a significant drop in the prices of medicines in France once they are registered for reimbursement. France is affected by a limited, but costly, flow of innovative medicines, whose prices are higher than those of previous generations, a reflection of an international gradient to which France is obviously subject, despite prices that remain at the low end of the range in Western Europe. The provision of innovative medicines for all patients who need them has been ensured in France over the last fifteen years at a controlled cost. But with the arrival of new expensive products, a resolute policy of control of expenditures must take over from the fall in prices, and original financing channels will have to be explored. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Repetitive transcranial magnetic stimulation: A potential therapy for cognitive disorders?

PubMed

Nouhaud, C; Sherrard, R M; Belmin, J

2017-03-01

Considering the limited effectiveness of drugs treatments in cognitive disorders, the emergence of noninvasive techniques to modify brain function is very interesting. Among these techniques, repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and have potential therapeutic effects on cognition and behaviour. These effects are due to physiological modifications in the stimulated cortical tissue and their associated circuits, which depend on the parameters of stimulation. The objective of this article is to specify current knowledge and efficacy of rTMS in cognitive disorders. Previous studies found very encouraging results with significant improvement of higher brain functions. Nevertheless, these few studies have limits: a few patients were enrolled, the lack of control of the mechanisms of action by brain imaging, insufficiently formalized technique and variability of cognitive tests. It is therefore necessary to perform more studies, which identify statistical significant improvement and to specify underlying mechanisms of action and the parameters of use of the rTMS to offer rTMS as a routine therapy for cognitive dysfunction. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Issues and difficulties in the relationship between patients and caregivers in painful sickle cell vaso-occlusive crisis].

PubMed

Dzierzynski, N; Stankovic Stojanovic, K; Georgin-Lavialle, S; Lionnet, F

2016-02-01

Sickle cell patients in acute pain situation experiment cognitive, behavioral and emotional changes that can accentuate their pain and disrupt communication with caregivers. On the other hand, caregivers have to face pain assessment difficulties and their own psychological reactions to their patient's pain. The gap between the patient's experience and caregiver's evaluation can lead to conflict and non-adherence treatment, and have a direct impact on the sickle cell disease prognosis. There is nothing inevitable about these phenomena, whose knowledge allows the action and opens up prospects for improving the management of sickle cell disease pain. This article is a narrative review updating the interactions between acute pain and some configurations, such as the inability to discern emotions, catastrophizing, post-traumatic stress or feeling ostracized. The overestimation of patient's addiction by caregivers also influences the pain itself. Open communication, as well as some treatments, medicated or not, a consistent institutional organization and a multidisciplinary approach altogether have an analgesic role by acting on pain cognitive and emotional components. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Implementation of flu vaccination in community pharmacies: Understanding the barriers and enablers.

PubMed

Kirkdale, C L; Nebout, G; Taitel, M; Rubin, J; Jacinto, I; Horta, R; Megerlin, F; Thornley, T

2017-01-01

Improving influenza vaccination coverage has been, and still remains a challenge internationally. There are now many examples where countries have pursued a pharmacist-led influenza vaccination service in order to enhance vaccination coverage of at-risk populations. England, Portugal and the United States are successful examples where their experience implementing this service can now be explored retrospectively and learnt from. This review aims to provide evidence to help overcome barriers to commissioning and implementation of such services in countries new to the experience. Implementation is influenced by differing regulatory frameworks underpinning the provision of pharmacist-led influenza vaccination, methods of remuneration, training, and operating procedures. Practical aspects such as the facilities required, how patient records are maintained and how patients and other healthcare professionals are engaged also have an impact. These examples illustrate how community pharmacists can be trained to deliver influenza vaccinations safely, and coupled with their accessibility and convenience, can provide a complementary service to that already provided by family doctors and nurses to deliver influenza vaccinations for the benefit of patients. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Current treatment and epidemiology of Clostridium difficile infections].

PubMed

Dinh, A; Bouchand, F; Le Monnier, A

2015-09-01

During the past 10years, Clostridium difficile infections (CDI) have become a major public health challenge. Their epidemiology has changed with a rise in the number of cases and an increase in severe episodes. Recurrence and failure of conventional treatments have become more common. Furthermore, a spread of CDI has been observed in the general population-involving subjects without the usual risk factors (unexposed to antibiotic treatment, young people, pregnant women, etc.). All these change are partially due to the emergence of the hypervirulent and hyperepidemic clone NAP1/B1/027. New therapeutic strategies (antimicrobial treatment, immunoglobulins, toxin chelation, fecal microbiota transplantation) are now available and conventional treatments (metronidazole and vancomycin) have been reevaluated with new recommendations. Recent studies show a better efficacy of vancomycin compared to metronidazole for severe episodes. Fidaxomicin is a novel antibiotic drug with interesting features, including an efficacy not inferior to vancomycin and a lower risk of recurrence. Finally, for multi-recurrent forms, fecal microbiota transplantation seems to be the best option. We present the available data in this review. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Children and screens: Groupe de Pédiatrie Générale (Société française de pédiatrie) guidelines for pediatricians and families.

PubMed

Picherot, G; Cheymol, J; Assathiany, R; Barthet-Derrien, M-S; Bidet-Emeriau, M; Blocquaux, S; Carbajal, R; Caron, F-M; Gerard, O; Hinterman, M; Houde, O; Jollivet, C; Le Heuzey, M-F; Mielle, A; Ogrizek, M; Rocher, B; Samson, B; Ronziere, V; Foucaud, P

2018-02-01

The Groupe de Pédiatrie Générale (General Pediatrics Group), a member of the Société française de pédiatrie (French Pediatrics Society), has proposed guidelines for families and doctors regarding children's use of digital screens. A number of guidelines have already been published, in particular by the French Academy of Sciences in 2013 and the American Academy of Pediatrics in 2016. These new guidelines were preceded by an investigation into the location of digital screen use by young children in France, a survey of medical concerns on the misuse of digital devices, and a review of their documented benefits. The Conseil Supérieur de l'Audiovisuel (Higher Council on Audiovisual Technology) and the Union Nationale de Associations Familiales (National Union of Family Associations) have taken part in the preparation of this document. Five simple messages are proposed: understanding without demonizing; screen use in common living areas, but not in bedrooms; preserve time with no digital devices (morning, meals, sleep, etc.); provide parental guidance for screen use; and prevent social isolation. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

[HPV (Human Papilloma Virus) implication in other cancers than gynaecological].

PubMed

Badoual, C; Tartour, E; Roussel, H; Bats, A S; Pavie, J; Pernot, S; Weiss, L; Mohamed, A Si; Thariat, J; Hoffmann, C; Péré, H

2015-08-01

Worldwide, approximately 5 to 10% of the population is infected by a Human Papilloma Virus (HPV). Some of these viruses, with a high oncogenic risk (HPV HR), are responsible for about 5% of cancer. It is now accepted that almost all carcinomas of the cervix and the vulva are due to an HPV HR (HPV16 and 18) infection. However, these viruses are known to be involved in the carcinogenesis of many other cancers (head and neck [SCCHN], penis, anus). For head and neck cancer, HPV infection is considered as a good prognostic factor. The role of HPV HR in anal cancer is also extensively studied in high-risk patient's population. The role of HPV infection in the carcinogenesis of esophageal, bladder, lung, breast or skin cancers is still debated. Given the multiple possible locations of HPV HR infection, the question of optimizing the management of patients with a HPV+ cancer arises in the implementation of a comprehensive clinical and biological monitoring. It is the same in therapeutics with the existence of a preventive vaccination, for example. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Ocular manifestations of Behçet's disease].

PubMed

Saadoun, D; Cassoux, N; Wechsler, B; Boutin, D; Terrada, C; Lehoang, P; Bodaghi, B; Cacoub, P

2010-08-01

Eye involvement in Behçet's disease (BD) is frequent and an important cause of morbidity. The mean age at onset of uveitis is between 20 and 30 years in male and 30 years in female patients. Ocular involvement includes anterior, posterior or panuveitis. Uveitis may be the presenting manifestation of the disease in 20% of cases or may appear 2 or 3 years after the disease onset. The estimated risk of blindness at 5 years ranges from 15 to 25%. The main goals in the management of patients with BD uveitis are the rapid control of intraocular inflammation, the prevention of recurrent attacks, the achievement of complete remission, and preservation of vision. The medical treatment of patients with severe uveitis relies on the use of systemically administered drugs, including corticosteroids and cytotoxic agents. Anti-TNF agents and interferon-alpha seem to be efficient and well-tolerated alternative therapeutic options. Controlled clinical trials are mandatory to define the place of these new immunomodulatory agents in the therapeutic strategy, and especially their use as first-line therapy. Copyright (c) 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Henoch-Schönlein purpura in the adult].

PubMed

Pillebout, E; Verine, J

2014-06-01

Henoch-Schönlein purpura is a systemic vasculitis of the small vessels characterized by perivascular leucocyte infiltrates. It is an immunoglobulin A-related immune complex-mediated disease involving the skin, the joints and the gastrointestinal system. Renal disease may sometimes be associated to these clinical manifestations. Prevalence of the nephritis is highly variable, depending on the series. More rarely, other organs such as the lungs, the heart or the nervous system may be involved. The clinical diagnosis is confirmed by histopathology of the skin (leukocytoclastic vasculitis) and kidney (endo-capillary proliferative glomerulonephritis), showing IgA deposits in these tissues. Short-term prognosis depends on the severity of digestive involvement, but long-term prognosis depends on the renal disease. Recent publications of pediatric and adult series show that the chronic renal failure may progress, sometimes more than ten years after the initial flare. Treatment is usually supportive. The benefit of more specific treatments (corticosteroids or immunosuppressive drugs) in severe visceral forms (usually abdominal or kidney) has not yet been established. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

FOREWORD: International Conference on Heavy Ion Collisions in the LHC Era

NASA Astrophysics Data System (ADS)

Arleo, Francois; Salgado, Carlos A.; Tran Thanh Van, Jean

2013-03-01

The International Conference on Heavy Ion Collisions in the LHC Era was held in Quy Nhon, Vietnam, on 16-20 July 2012. The series Rencontres du Vietnam, created by Jean Tran Thanh Van in 1993, consists of international meetings aimed to stimulate the development of advanced research in Vietnam and more generally in South East Asia, and to establish collaborative research networks with Western scientific communities. This conference, as the whole series, also supports the International Center for Interdisciplinary Science Education being built in Quy Nhon. The articles published in this volume present the latest results from the heavy-ion collision programs of RHIC and LHC as well as the corresponding theoretical interpretation and future perspectives. Lower energy nuclear programs were also reviewed, providing a rather complete picture of the state-of-the-art in the field. We wish to thank the sponsors of the Conference on Heavy Ion Collisions in the LHC Era: the European Research Council; Xunta de Galicia (Spain); EMMI (Germany) and Agence Nationale de la Recherche (France) François Arleo (Laboratoire d'Annecy-le-Vieux de Physique Théorique, France) Francois Arleo, Carlos A Salgado and Jean Tran Thanh Van Conference photograph

Stability studies on florfenicol using developed derivative spectrophotometric methods.

PubMed

Elimam, M M; Shantier, S W; Gadkariem, E A; Mohamed, M A; Osman, Z

2017-01-01

This study aims to investigate the stability of florfenicol using previously developed derivative spectrophotometric methods (D 1 and D 2 ). The studied stability-indicating pararmeters included alkali (NaOH, 1M), acid (HCl, 1M), pH changes (buffer pH 2.2-11), temperature (80°C and 100°C at pH 10) and light. A constructed pH profile for the drug degradation rate revealed a significant effect of pH on the drug stability between pH ranges 8 and 11. The obtained profile indicated first order dependence of K obs on [OH - ]. Arrhenius plot at pH 10 was found linear at temperatures 80°C and 100°C with estimated activation energy of 19.35kcal/mol. The calculated rate constant (K obs ), t ½ and t 90 at 25°C were found to be 1.8×10 -3 h, 385h and 58.3h, respectively. The photostability of florfenicol was also studied by exposing the drug solution to direct sunlight during mid-day time. The obtained results reflected the instability of florfenicol under the study conditions. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

FRIPON, the French fireball network

NASA Astrophysics Data System (ADS)

Colas, F.; Zanda, B.; Bouley, S.; Vaubaillon, J.; Marmo, C.; Audureau, Y.; Kwon, M. K.; Rault, J. L.; Caminade, S.; Vernazza, P.; Gattacceca, J.; Birlan, M.; Maquet, L.; Egal, A.; Rotaru, M.; Gruson-Daniel, Y.; Birnbaum, C.; Cochard, F.; Thizy, O.

2015-10-01

FRIPON (Fireball Recovery and InterPlanetary Observation Network) [4](Colas et al, 2014) was recently founded by ANR (Agence Nationale de la Recherche). Its aim is to connect meteoritical science with asteroidal and cometary science in order to better understand solar system formation and evolution. The main idea is to set up an observation network covering all the French territory to collect a large number of meteorites (one or two per year) with accurate orbits, allowing us to pinpoint possible parent bodies. 100 all-sky cameras will be installed at the end of 2015 forming a dense network with an average distance of 100km between stations. To maximize the accuracy of orbit determination, we will mix our optical data with radar data from the GRAVES beacon received by 25 stations [5](Rault et al, 2015). As both the setting up of the network and the creation of search teams for meteorites will need manpower beyond our small team of professionals, we are developing a citizen science network called Vigie-Ciel [6](Zanda et al, 2015). The public at large will thus be able to simply use our data, participate in search campaigns or even setup their own cameras.

Effect of the band structure in a rigorous two-body model with long-range interactions in 1D optical lattices

NASA Astrophysics Data System (ADS)

Kristensen, Tom; Simoni, Andrea; Launay, Jean-Michel

2016-05-01

We compute scattering and bound state properties for two ultracold molecules in a pure 1D optical lattice. We introduce reference functions with complex quasi-momentum that naturally account for the effect of excited energy bands. Our exact results for a short-range interaction are first compared with the simplest version of the standard Bose-Hubbard (BH) model. Such comparison allows us to highlight the effect of the excited bands, of the non-on-site interaction and of tunneling with distant neighbor, that are not taken into account in the BH model. The effective interaction can depend strongly on the particle quasi-momenta and can present a resonant behavior even in a deep lattice. As a second step, we study scattering of two polar particles in the optical lattice. Peculiar Wigner threshold laws stem from the interplay of the long range dipolar interaction and the presence of the energy bands. We finally assess the validity of an extended Bose-Hubbard model for dipolar gases based on our exact two-body calculations. This work was supported by the Agence Nationale de la Recherche (Contract No. ANR-12-BS04-0020-01).

[The roles and the impacts of pharmacists in the management of medical devices at the hospital: A literature review].

PubMed

Ferrand, É; Painchart, L; Grimandi, G; Décaudin, B; Bussières, J-F

2017-11-01

Identify the training profile and the published evidences about the roles and the impacts of hospital pharmacists in medical devices. A literature review was conducted using Google, Google Scholar and Pubmed for 1990-2016 associated with a manual search conducted in three non-indexed pharmaceutical journals for 2000-2016. The analysis of training programs available did not allow us to identify a specific training profile. A total of 72 articles related to the roles and the impacts of the pharmacist were identified, 52 of which came from non-indexed journals. Those articles did not deal specifically about the roles and the impacts of pharmacist; however, articles were analyses for three spheres including the referencing of medical devices (n=36), the evaluation (n=19) and the distribution system (n=13). French pharmacists have many theoretical and practical training opportunities. There are a few articles describing precisely the roles and the impacts of hospital pharmacists in medical device. It appears urgent to better document this activity in professional and indexed literature. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Application of robustness test for assessment of the measurement uncertainty at the end of development phase of a chromatographic method for quantification of water-soluble vitamins].

PubMed

Ihssane, B; Bouchafra, H; El Karbane, M; Azougagh, M; Saffaj, T

2016-05-01

We propose in this work an efficient way to evaluate the measurement of uncertainty at the end of the development step of an analytical method, since this assessment provides an indication of the performance of the optimization process. The estimation of the uncertainty is done through a robustness test by applying a Placquett-Burman design, investigating six parameters influencing the simultaneous chromatographic assay of five water-soluble vitamins. The estimated effects of the variation of each parameter are translated into standard uncertainty value at each concentration level. The values obtained of the relative uncertainty do not exceed the acceptance limit of 5%, showing that the procedure development was well done. In addition, a statistical comparison conducted to compare standard uncertainty after the development stage and those of the validation step indicates that the estimated uncertainty are equivalent. The results obtained show clearly the performance and capacity of the chromatographic method to simultaneously assay the five vitamins and suitability for use in routine application. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[City-hospital network and quality control of officinal preparations].

PubMed

Curti, C; Gallice, S; Lamy, E; Rathelot, P; Vanelle, P

2018-05-01

In a hospital environment, the quality control of the hospital preparations allows to release homogeneous batches in a secure way. These controls are totally integrated into the process of production and can also, in certain cases, be realized for high-alert magistral preparations. In community pharmacy, these controls were not required, but the Agence régionale de santé (ARS) recently incited compounding community pharmacies to realize this type of analyses. This decision motivated the creation of a collaboration between the pharmacy department of a French teaching hospital and a society including around thirty community pharmacies having a preparatory. Twenty community pharmacies distributed on all the territory have submitted one of their pediatric preparation, capsules of captopril 2mg, to the pharmacopoeia controls usually realized in the industry or hospital. All the analyzed batches were in agreement with European Pharmacopeia specifications. We shall present the rational of this work, the results as well as the numerous perspectives offered by this new type of collaboration joining completely the logic of a network city-hospital allowing the improvement of security of the medication circuit in France. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Caater: Arat - Fokker 27, aircraft facility

NASA Astrophysics Data System (ADS)

Penazzi, G.; Joussaume, S.

2003-04-01

ARAT (Avion de Recherche Atmosphérique et de Télédétection), is owned and operated by IGN (Institut Géographique National) and managed by INSU, an institute of CNRS (Centre National de la Recherche Scientifique). ARAT is a versatile flying laboratory offering several scientific configurations: basic meteorological instrumentation, turbulent flux equipment, radiation measurement (Visible, Red, IR, UV, J(NO_2), radiance, ground temperature), microphysics sensors, in-situ and remote sensing chemistry instruments (NO-NO_2-NOy and PAN, Water Vapour and Ozone Lidars), Aerosol Lidar, Earth Observation Instrumentation (Visible, Microwave, POLDER), etc. Access to ARAT was offered through the EC-funded IHP-ARI contract, under a co-ordinated aircraft project (with MRF, U.K.; DLR, Germany and Meteo France) called CAATER (Co-ordinated Access to Aircraft for Transnational Environmental Research). Since 2000 access to ARAT has been offered to 6 research groups from different EU Member States for about 10 flight hours each. This project is a follow-on to STAAARTE (1996-2000), which gave access to ARAT to 14 user groups for about 8 flight hours per group. A new project, with new aircraft, within the frame of an Integrated Infrastructure Initiative of the Sixth Framework Programme is currently in preparation.

Origin of the Counterintuitive Dynamic Charge in the Transition-Metal Dichalcogenides

NASA Astrophysics Data System (ADS)

Pike, Nicholas; van Troeye, Benoit; Dewandre, Antoine; Gonze, Xavier; Verstraete, Matthieu

Our recent first-principles calculations of the electronic and vibrational properties of the hexagonal transition-metal dichalcogenides reveal that their Born effective charges display a counterintuitive sign when compared to most other materials or transition-metal dichalcogenides with trigonal symmetry. We determine the origin of this counterintuitive sign by calculating the electronic, vibrational, and optical properties of these systems. We show that the sign of the Born effective charge is directly related to the electric field response of the electronic density, and, in turn, to the bonding characteristics of the material.There is a filled anti-bonding molecular orbital at the Fermi level, which is localized on the transition-metal atom and corresponds to a form of solid state π back-bonding in these material. We propose a method of determining if other materials display a similar counterintuitive sign, based on their bonding characteristics, and propose experiments which could measure the sign of the Born effective charge using different spectroscopies. The authors acknowledge the Belgian Fonds National de la Recherche Scientifique FNRS under PDR T.1077.15-1/7, a FRIA Grant, ULg, and from the Communauté Française de Belgique (ARC AIMED 15/19-09).

Facility for assessing spectral normal emittance of solid materials at high temperature.

PubMed

Mercatelli, Luca; Meucci, Marco; Sani, Elisa

2015-10-10

Spectral emittance is a key topic in the study of new compositions, depositions, and mechanical machining of materials for solar absorption and for renewable energies in general. The present work reports on the realization and testing of a new experimental facility for the measurement of directional spectral emittance in the range of 2.5-20 μm. Our setup provides emittance spectral information in a completely controlled environment at medium-high temperatures up to 1200 K. We describe the layout and first tests on the device, comparing the results obtained for hafnium carbide and tantalum diboride ultrarefractory ceramic samples to previous quasi-monochromatic measurements carried out in the PROMES-CNRS (PROcedes, Materiaux et Energie Solaire- Centre National de la Recherche Scientifique, France) solar furnace, obtaining a good agreement. Finally, to assess the reliability of the widely used approach of estimating the spectral emittance from room-temperature reflectance spectrum, we compared the calculation in the 2.5-17 μm spectral range to the experimental high-temperature spectral emittance, obtaining that the spectral trend of calculated and measured curves is similar but the calculated emittance underestimates the measured value.

L'astronomie au féminin

NASA Astrophysics Data System (ADS)

Nazé, Yaël

2006-03-01

Qui détient le record des découvertes de comètes ? Une femme. Qui a permis de comprendre comment est organisée la population des étoiles ? Une femme. Qui a découvert la loi permettant d'arpenter l'Univers, a trouvé des phares dans l'espace, a compris le fonctionnement des forges stellaires et a bouleversé notre vision de l'Univers ? Encore et toujours une femme... Pourtant, quand on doit citer un astronome -- historique -- au hasard, on pense le plus souvent -- des hommes : Ptolémée, Galilée, Copernic ou, plus près de nous par exemple, Hubble. Certes, au cours des siècles, les femmes n'ont guère eu accès aux sciences en général et -- l'astronomie en particulier mais ce n'est pas une raison pour croire en l'absence totale de contributions dues au beau sexe ! C'est ce que dévoile ici l'auteur. Loin de toute forme de féminisme enragé, on suivra le parcours de quelques scientifiques importantes qui ont par hasard en commun une même particularité : leur sexe.

Role of Elasto-Inertial Turbulence in Polymer Drag Reduction

NASA Astrophysics Data System (ADS)

Dubief, Yves; Sid, Samir; Terrapon, Vincent

2017-11-01

Elasto-Inertial Turbulence (EIT) is a peculiar state of turbulence found in dilute polymer solutions flowing in parallel wall flows over a wide range of Reynolds numbers. At subcritical Reynolds numbers, appropriate boundary conditions trigger EIT, a self-sustaining cycle of energy transfers between thin sheets of stretched polymers and velocity perturbations, which translates into an increase of friction drag. For critical and supercritical Reynolds numbers, polymer additives may lead to significant drag reduction, bounded by the asymptotic state known as Maximum Drag Reduction (MDR). The present research investigates the role of EIT in the dynamics of critical and supercritical Reynolds number wall flows. Using high-fidelity direct numerical simulations of channel flows and the FENE-P model, we establish that (i) EIT is two-dimensional, (ii) the scales essential to the existence of EIT are sub-Kolmogorov, and (iii) EIT drives MDR at low and possibly moderate Reynolds number turbulent flows. These findings were validated in two different codes and using unprecedented resolutions for polymer flows. YD is grateful for the support of Binational Science Foundation. SS and VT acknowledges Fonds de la Recherche Scientifique (FNRS), MarieCurie Career Integration Grant and computing allocation from University of Liege and PRACE.

Magnetic field topology of the cool, active, short-period binary system σ2 Coronae Borealis

NASA Astrophysics Data System (ADS)

Rosén, L.; Kochukhov, O.; Alecian, E.; Neiner, C.; Morin, J.; Wade, G. A.; BinaMIcS Collaboration

2018-06-01

Aims: The goal of this work is to study the cool, active binary star σ2 CrB, focussing on its magnetic field. The two F9-G0 components of this system are tidally locked and in a close orbit, increasing the chance of interaction between their magnetospheres. Methods: We used Stokes IV data from the twin spectropolarimeters Narval at the TBL and ESPaDOnS at the CFHT. The least-squares deconvolution multi-line technique was used to increase the signal-to-noise ratio of the data. We then applied a new binary Zeeman-Doppler imaging code to reconstruct simultaneously the magnetic topology and brightness distribution of both components of σ2 CrB. This analysis was carried out for two observational epochs in 2014 and 2017. Results: A previously unconfirmed magnetic field of the primary star has been securely detected. At the same time, the polarisation signatures of the secondary appear to have a systematically larger amplitude than that of the primary. This corresponds to a stronger magnetic field, for which the magnetic energy of the secondary exceeds that of the primary by a factor of 3.3-5.7. While the magnetic energy is similar for the secondary star in the two epochs, the magnetic energy is about twice as high in 2017 for the primary. The magnetic field topology of the two stars in the earlier epoch (2014) is very different. The fractions of energy in the dipole and quadrupole components of the secondary are similar and thereafter decrease with increasing harmonic angular degree ℓ. At the same time, for the primary the fraction of energy in the dipole component is low and the maximum energy contribution comes from ℓ = 4. However, in the 2017 epoch both stars have similar field topologies and a systematically decreasing energy with increasing ℓ. In the earlier epoch, the magnetic field at the visible pole appears to be of opposite polarity for the primary and secondary, suggesting linked magnetospheres. The apparent rotational periods of both σ2 CrB components are longer than the orbital period, which we interpret as an evidence of a solar-like differential rotation. Conclusions: Despite their nearly identical fundamental parameters, the components of σ2 CrB system exhibit different magnetic field properties. This indicates that the magnetic dynamo process is a very sensitive function of stellar parameters. Based on observations obtained at the Bernard Lyot Telescope (TBL; Pic du Midi, France) of the Midi-Pyrénées Observatory, which is operated by the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France. Also based on observations obtained at the Canada-France-Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii.

Preface: Materiaux 2010

NASA Astrophysics Data System (ADS)

Cheikhrouhou, Abdelwaheb

2012-02-01

The national conference 'MATERIAUX 2010', which took place in Mahdia (Tunisia), from 4-7 November 2010 was organized by The 'Tunisian Materials Research Society: Tu-MRS' in collaboration with the Materials Physics Laboratory of Sfax 'LPM', Faculty of Sciences, Sfax University and the Research Unit ' Physique, Informatique et Mathématiques ', Faculty of Sciences, Gafsa University The First National Conference on Materials 'MATERIAUX 2006' was organized in Douz (Tunisia) in December 2006. This was followed by 'MATERIAUX 2007' held in Hammamet (Tunisia) in April 2007 and the National Conference 'MATERIAUX 2009' organized jointly with the Second 'Journées Internationales de la Physique des Matériaux et Applications: JIPMA 2009' in Gafsa (Tunisia) from 20-24 December 2009. 'MATERIAUX 2010' is intended to provide an excellent opportunity for National, Maghreb and International researchers to make their own work on materials known to a wider audience and to have discussions with other participants. This conference will also be an opportunity to exchange experiences, create and consolidate cooperation between different research structures in the Maghreb countries and also the countries around the Mediterranean. This conference will equally promote research development, contribution to collaboration between universities and the socio-economical milieu. More than 300 senior researchers, Professors, PhD and Masters students attended this conference from Tunisia, Algeria, Morocco, France, Spain and Canada. Several researchers, engineers and managers from industrial firms also attended. The conference consisted of plenary talks (8), oral contributions (40) and poster presentations (250). The topics of the Conference were: Nano-materials, nano-systems, thin films, surfaces and interfaces, applications Multifunctionnal materials, magnetic materials, dielectric materials, superconducting materials, applications,... Materials for electronics, informatics and communication Ceramics, glasses, polymers Natural materials (phosphates, clay,...) Metallic materials, alloys, metallurgy,... Others (materials and environment, materials and energy, biomaterials,...) I want to thank the scientific committee, the organizing committee, the local committee and everyone who contributed to the organization of this meeting for their invaluable efforts in order to guarantee the complete success of this conference. Abdelwaheb Cheikhrouhou President of 'Tu-MRS' Chairman of the Conference 'MATERIAUX 2010' Conference photograph Committies Organizing Committee Chairman CHEIKHROUHOU Abdelwaheb (Faculté des Sciences de Sfax) Members ALAYA Sahbi (Faculté des Sciences de Gabès) BENNACEUR Raouf (Faculté des Sciences de Tunis) BEN SALEM Mohamed (Faculté des Sciences de Bizerte) CHEIKHROUHOU-KOUBAA Wissem (Faculté des Sciences de Sfax) EL JANI Belgacem (Faculté des Sciences de Monastir) EZZAOUIA Hatem (Centre de Recherches et de Technologies de l'Energie, Technopole de Borj Cédria) LAMLOUMI Jilani (Ecole Supérieure des Sciences et Techniques de Tunis) REZIG Bahri (Ecole Nationale d'Ingénieurs de Tunis) Local Committee Chairman CHEIKHROUHOU Abdelwaheb (Faculté des Sciences de Sfax) Members CHEIKHROUHOU-KOUBAA Wissem (Faculté des Sciences de Sfax) KOUBAA Mohamed (Institut Supérieur de Biotechnologie de Sfax) NJEH Anwar (Institut Préparatoire aux Etudes d'Ingénieurs de Sfax) BEN SALAH Issam (Faculté des Sciences de Sfax) TAKKALI Férid (Faculté des Sciences de Sfax) REGAIEG Yassin (Faculté des Sciences de Sfax) OTHMANI Safa (Faculté des Sciences de Sfax) MNASSRI Rafik (Faculté des Sciences de Sfax) Secretariat BEN GHOZLEN Afifa (Faculté des Sciences de Sfax) BOUGHARIOU Sana (Faculté des Sciences de Sfax) Scientific Committee M. ADDOU, Faculté des Sciences de Kénitra (Morocco) N. AMDOUNI, Faculté des Sciences de Tunis (Tunisia) M. BACCOUCHE, Faculté des Sciences d'Annaba (Algeria) H. BATIS, Faculté des Sciences de Tunis (Tunisia) A. BELAFHAL, Faculté des Sciences d'El Jadida (Morocco) M.H. BEN GHOZLEN, Faculté des Sciences de Sfax (Tunisia) R. BENNACEUR, Faculté des Sciences de Tunis (Tunisia) B. BENYOUCEF, Université Abou Bakr Belkaid, Tlemcen (Algeria) M. BEN SALEM, Faculté des Sciences de Bizerte (Tunisia) B. BESSAIES, Centre de Recherches et Technologies de l'Energie (Tunisia) H. BOUCHRIHA, Faculté des Sciences de Tunis (Tunisia) W. BOUJELBEN, Faculté des Sciences de Sfax (Tunisia) A. CHEIKHROUHOU, Faculté des Sciences de Sfax (Tunisia) W. CHEIKHROUHOU-KOUBAA, Faculté des Sciences de Sfax (Tunisia) R. CHTOUROU, Centre de Recherches et Technologies de l'Energie (Tunisia) M. DEBBABI, Ecole Nationale d'Ingénieurs de Monastir (Tunisia) A. DAKHLAOUI, Faculté des Sciences de Bizerte (Tunisia) A. DINIA, Université de Strasbourg (France) B. ELJANI, Faculté des Sciences de Monastir (Tunisia) A. ELJAZOULI, Faculté des Sciences Ben Msik, Casablanca (Morocco) Z. FAKHFAKH, Faculté des Sciences de Sfax (Tunisia) A. GASMI, Faculté des Sciences d'Annaba (Algeria) A. GHARBI, Faculté des Sciences de Tunis (Tunisia) R. GHARBI, Faculté des Sciences de Sfax (Tunisia) K. GUIDARA, Faculté des Sciences de Sfax (Tunisia) H. GUERMAZI, Institut Préparatoire aux Etudes d'Ingénieurs de Sfax (Tunisia) S. GUERMAZI, Faculté des Sciences de Sfax (Tunisia) M. HADDAD, Faculté des Sciences de Meknès (Morocco) A. HAJ AMARA, Faculté des Sciences de Bizerte (Tunisia) D. HAMANA, Faculté des Sciences de Constantine (Algeria) N. KAMOUN, Faculté des Sciences de Tunis (Tunisia) S. KADDOUR-CHARFI, Faculté des Sciences de Tunis (Tunisia) M. KADDOUR, Faculté des Sciences de Sfax (Tunisia) M. KHITOUNI, Faculté des Sciences de Sfax (Tunisia) T. MHIRI, Faculté des Sciences de Sfax (Tunisia) Y. MLIK, Institut Préparatoire aux Etudes Scientifiques et Techniques (Tunisia) N. MLIKI, Faculté des Sciences de Tunis (Tunisia) A. NJAH, Faculté des Sciences de Gafsa (Tunisia) M. OUESLATI, Faculté des Sciences de Tunis (Tunisia) K. ZELLAMA, Faculté des Sciences d'Amiens (France) Invited Speakers AMMAR-MERIAH Souad, ITODYS, Université Paris Diderot (France) BEN SALEM Mohamed, Faculté des Sciences de Bizerte, Université du 7 Novembre á Carthage (Tunisia) CHEIKHROUHOU Abdelwaheb, Faculté des Sciences de Sfax, Université de Sfax (Tunisia) DAKHLAOUI Amel, Faculté des Sciences de Bizerte, Université du 7 Novembre á Carthage (Tunisia) DJABBAR Ahmed, Université des Sciences et des Technologies de Lille (France) DURASTANTI Félix, Centre d'Etudes et Recherche en Thermique, Environnement et Systèmes (C.E.R.T.E.S.), Université Paris Est- Créteil (France) FERY-FORGUES Suzanne, Université Paul Sabatier, Toulouse (France) GIRAUD Romain, Laboratoire de Photonique et de Nanostructures, CNRS/LPN, Marcoussis (France)

[Clinical overview of auto-inflammatory diseases].

PubMed

Georgin-Lavialle, S; Rodrigues, F; Hentgen, V; Fayand, A; Quartier, P; Bader-Meunier, B; Bachmeyer, C; Savey, L; Louvrier, C; Sarrabay, G; Melki, I; Belot, A; Koné-Paut, I; Grateau, G

2018-04-01

Monogenic auto-inflammatory diseases are characterized by genetic abnormalities coding for proteins involved in innate immunity. They were initially described in mirror with auto-immune diseases because of the absence of circulating autoantibodies. Their main feature is the presence of peripheral blood inflammation in crisis without infection. The best-known auto-inflammatory diseases are mediated by interleukines that consisted in the 4 following diseases familial Mediterranean fever, cryopyrinopathies, TNFRSF1A-related intermittent fever, and mevalonate kinase deficiency. Since 10 years, many other diseases have been discovered, especially thanks to the progress in genetics. In this review, we propose the actual panorama of the main known auto-inflammatory diseases. Some of them are recurrent fevers with crisis and remission; some others evaluate more chronically; some are associated with immunodeficiency. From a physiopathological point of view, we can separate diseases mediated by interleukine-1 and diseases mediated by interferon. Then some polygenic inflammatory diseases will be shortly described: Still disease, Schnitzler syndrome, aseptic abscesses syndrome. The diagnosis of auto-inflammatory disease is largely based on anamnesis, the presence of peripheral inflammation during attacks and genetic analysis, which are more and more performant. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Costless Platform for High Resolution Stereoscopic Images of a High Gothic Facade

NASA Astrophysics Data System (ADS)

Héno, R.; Chandelier, L.; Schelstraete, D.

2012-07-01

In October 2011, the PPMD specialized master's degree students (Photogrammetry, Positionning and Deformation Measurement) of the French ENSG (IGN's School of Geomatics, the Ecole Nationale des Sciences Géographiques) were asked to come and survey the main facade of the cathedral of Amiens, which is very complex as far as size and decoration are concerned. Although it was first planned to use a lift truck for the image survey, budget considerations and taste for experimentation led the project to other perspectives: images shot from the ground level with a long focal camera will be combined to complementary images shot from what higher galleries are available on the main facade with a wide angle camera fixed on a horizontal 2.5 meter long pole. This heteroclite image survey is being processed by the PPMD master's degree students during this academic year. Among other type of products, 3D point clouds will be calculated on specific parts of the facade with both sources of images. If the proposed device and methodology to get full image coverage of the main facade happen to be fruitful, the image acquisition phase will be completed later by another team. This article focuses on the production of 3D point clouds with wide angle images on the rose of the main facade.

[Hyper-reactive malarial splenomegaly].

PubMed

Maazoun, F; Deschamps, O; Barros-Kogel, E; Ngwem, E; Fauchet, N; Buffet, P; Froissart, A

2015-11-01

Hyper-reactive malarial splenomegaly is a rare and severe form of chronic malaria. This condition is a common cause of splenomegaly in endemic areas. The pathophysiology of hyper-reactive malarial splenomegaly involves an intense immune reaction (predominantly B cell-driven) to repeated/chronic infections with Plasmodium sp. The diagnosis may be difficult, due to a poorly specific clinical presentation (splenomegaly, fatigue, cytopenias), a long delay between residence in a malaria-endemic area and onset of symptoms, and a frequent absence of parasites on conventional thin and thick blood smears. A strongly contributive laboratory parameter is the presence of high levels of total immunoglobulin M. When the diagnostic of hyper-reactive malarial splenomegaly is considered, search for anti-Plasmodium antibodies and Plasmodium nucleic acids (genus and species) by PCR is useful. Diagnosis of hyper-reactive malarial splenomegaly relies on the simultaneous presence of epidemiological, clinical, biological and follow-up findings. Regression of both splenomegaly and hypersplenism following antimalarial therapy allows the differential diagnosis with splenic lymphoma, a common complication of hyper-reactive malarial splenomegaly. Although rare in Western countries, hyper-reactive malarial splenomegaly deserves increased medical awareness to reduce the incidence of incorrect diagnosis, to prevent progression to splenic lymphoma and to avoid splenectomy. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Primary intestinal lymphangiectasia (Waldmann's disease)].

PubMed

Vignes, S; Bellanger, J

2017-08-31

Primary intestinal lymphangiectasia (PIL), Waldmann's disease, is a rare disorder of unknown etiology characterized by dilated intestinal lacteals leading to lymph leakage into the small-bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia. PIL is generally diagnosed before 3 years of age but may be diagnosed in older patients. The main symptom is bilateral lower limb edema. Edema may be moderate to severe including pleural effusion, pericarditis or ascites. Protein-losing enteropathy is confirmed by the elevated 24-h stool α1-antitrypsin clearance and diagnosis by endoscopic observation of intestinal lymphangiectasia with the corresponding histology of biopsies. Videocapsule endoscopy may be useful when endoscopic findings are not contributive. Several B-cell lymphomas of the gastrointestinal tract or with extra-intestinal localizations were reported in PIL patients. A long-term strictly low-fat diet associated with medium-chain triglyceride and liposoluble vitamin supplementation is the cornerstone of PIL medical management. Octreotide, a somatostatin analog, have been proposed with an inconsistent efficacy in association with diet. Surgical small-bowel resection is useful in the rare cases with segmental and localized intestinal lymphangiectasia. A prolonged clinical and biological follow-up is recommended. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

3D Model of Surfactant Replacement Therapy

NASA Astrophysics Data System (ADS)

Grotberg, James; Tai, Cheng-Feng; Filoche, Marcel

2015-11-01

Surfactant Replacement Therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. Though successful in neonatal applications, its use in adults had early success followed by failure. We present the first mathematical model of 3D SRT where a liquid plug propagates through the tree from forced inspiration. In two separate modeling steps, the plug first deposits a coating film on the airway wall which subtracts from its volume, a ``coating cost''. Then the plug splits unevenly at the airway bifurcation due to gravity. The steps are repeated until a plug ruptures or reaches the tree endpoint alveoli/acinus. The model generates 3D images of the resulting acinar distribution and calculates two global indexes, efficiency and homogeneity. Simulating published literature, the earlier successful adult SRT studies show comparatively good index values, while the later failed studies do not. Those unsuccessful studies used smaller dose volumes with higher concentration mixtures, apparently assuming a well mixed compartment. The model shows that adult lungs are not well mixed in SRT due to the coating cost and gravity effects. Returning to the higher dose volume protocols could save many thousands of lives annually in the US. Supported by NIH Grants HL85156, HL84370 and Agence Nationale de la Recherche, ANR no. 2010-BLAN-1119-05.

[Management of mesenteric ischemia in the era of intestinal stroke centers: The gut and lifesaving strategy].

PubMed

Nuzzo, A; Corcos, O

2017-09-01

Mesenteric ischemia is a gut and life-threatening, medical and surgical, digestive and vascular emergency. Mesenteric ischemia is the result of an arterial or venous occlusion, a vasospasm secondary to low-flow states in intensive care patients, aortic clamping during vascular surgery or intestinal transplantation. Progression towards mesenteric infarction and its complications is unpredictable and correlates with high rates of mortality or a high risk of short bowel syndrome in case of survival. Thus, mesenteric ischemia should be diagnosed and treated at an early stage, when gut injury is still reversible. Diagnostic workup lacks sensitive and specific clinical and biological marker. Consequently, diagnosis and effective therapy can be achieved by a high clinical suspicion and a specific multimodal management: the gut and lifesaving strategy. Based on the model of ischemic stroke centers, the need for a multidisciplinary and expert 24/24 emergency care has led, in 2016, to the inauguration of the first Intestinal Stroke Center (Structure d'urgences vasculaires intestinales [SURVI]) in France. This review highlights the pathophysiological features of chronic and acute mesenteric ischemia, as well as the diagnosis workup and the therapeutic management developed in this Intestinal Stroke Center. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Impact of an automated dispensing system for medical devices in cardiac surgery department].

PubMed

Clou, E; Dompnier, M; Kably, B; Leplay, C; Poupon, E; Archer, V; Paul, M

2018-01-01

To secure medical devices' management, the implementation of automated dispensing system in surgical service has been realized. The objective of this study was to evaluate security, organizational and economic impact of installing automated dispensing system for medical devices (ASDM). The implementation took place in a cardiac surgery department. Security impact was assessed by comparing traceability rate of implantable medical devices one year before and one year after installation. Questionnaire on nurses' perception and satisfaction completed this survey. Resupplying costs, stocks' evolution and investments for the implementation of ASDM were the subject of cost-benefit study. After one year, traceability rate is excellent (100%). Nursing staffs were satisfied with 87.5% by this new system. The introduction of ASDM allowed a qualitative and quantitative decrease in stocks, with a reduction of 30% for purchased medical devices and 15% for implantable medical devices in deposit-consignment. Cost-benefit analysis shows a rapid return on investment. Real stock decrease (purchased medical devices) is equivalent to 46.6% of investment. Implementation of ASDM allows to secure storage and dispensing of medical devices. This system has also an important economic impact and appreciated by users. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Lung is also involved in juvenile dermatomyositis].

PubMed

Pouessel, G; Thumerelle, C; Nève, V; Santangelo, T; Flammarion, S; Pruvot, I; Tillie-Leblond, I; Deschildre, A

2014-07-01

Juvenile dermatomyositis is the leading cause of chronic idiopathic inflammatory myopathy of auto-immune origin in children. Lung involvement in inflammatory myopathies is well described in adults, involving mostly interstitial lung disease, aspiration pneumonia and alveolar hypoventilation. We propose to describe its specificities in children. Pulmonary involvement may be asymptomatic and therefore must be systematically screened for. In case of clinical or functional respiratory abnormality, a chest computed tomographic (CT) scan is necessary. In children, a decrease of respiratory muscle strength seems common and should be systematically and specifically searched for by non-invasive and reproducible tests (sniff test). Interstitial lung disease usually associates restrictive functional defect, impairment of carbon monoxide diffusion and interstitial lung disease on CT scan. As in adults, the first-line treatment of juvenile dermatomyositis is based on corticosteroids. Corticosteroid resistant forms require corticosteroid bolus or adjuvant immunosuppressive drugs (methotrexate or cyclosporine). There is no consensus in pediatrics for the treatment of diffuse interstitial lung disease. Complications of treatment, including prolonged steroid therapy, are frequent and therefore a careful assessment of the treatments risk-benefit ratio is necessary, especially in growing children. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Physical activity and cancer: Update and literature review].

PubMed

Desnoyers, A; Riesco, E; Fülöp, T; Pavic, M

2016-06-01

Physical activity is a key determinant of public health and contributes to decreasing the prevalence of many diseases. Cancer is the leading cause of death worldwide. Physical activity, accessible to the entire population, could prevent up to 25% of cancers, in addition to improving survival rates and quality of life in cancer patients. Physical activity acts via various mechanisms to slow or decrease tumor growth, including the production and bioavailability of sex hormones, insulin resistance and insulin secretion, and inflammation. In primary prevention, physical activity reduces breast cancer risk by 15-20% and colorectal cancer risk by 24%. All-cause mortality is reduced by 33% in cancer survivors who exercise. Health-related quality of life, fatigue and depression are enhanced by the practice of physical activity in cancer patients. In the general population, the global recommendations on physical activity for health, published by the World Health Organisation, are suggested as a means of primary prevention of cancer. In cancer patients, an adapted physical activity routine is promoted from the very beginning of patient care to decrease fatigue as well as improve tolerance and benefits of treatments. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Biosimilars: from technical to pharmacoeconomic considerations. 30th Rencontres Nationales de Pharmacologie et Recherche clinique pour l'Innovation et l'Evaluation des Technologies de Santé. Tables rondes.

PubMed

Girault, Danièle; Trouvin, Jean-Hugues; Blachier-Poisson, Corinne; Gary, François; Laloye, Didier; Bergmann, Jean-François; Casadevall, Nicole; Delval, Cécile; De Sahb Berkovitch, Rima; Fagon, Jean-Yves; Gersberg, Marta; Lassale, Catherine; Lechat, Philippe; Le Jeunne, Claire; Montastruc, Jean-Louis; Prugnaud, Jean-Louis; Ratignier-Carbonneil, Christelle; Rey-Coquais, Cécile

2015-01-01

A biosimilar is a biological medicinal product claimed to be similar to a reference biological medicinal product. Its development plan includes studies comparing it with the reference product in order to confirm its similarity in terms of quality, preclinical safety, clinical efficacy, and clinical safety, including immunogenicity. Biosimilars differ from generics both in their molecular complexity and in the specific requirements that apply to them. Since patents on many biological medicinal products will expire within the next 5 years in major therapeutic areas such as oncology, rheumatology and gastroenterology and as those products are so costly to the French national health insurance system, the availability of biosimilars would have a considerable economic impact. The round table has issued a number of recommendations intended to ensure that the upcoming arrival of biosimilars on the market is a success, in which prescribing physicians would have a central role in informing and reassuring patients, an efficient monitoring of the patients treated with biologicals would be set up and time to market for biosimilars would be speeded up. © 2015 Société Française de Pharmacologie et de Thérapeutique.

[The permanence of access to health care: a tradition of hospitality and innovative organizational model].

PubMed

Georges-Tarragano, C

2015-01-01

The PASS ("Permanence d'Accès aux Soins de Santé") are hospital-based units providing primary care services to patients who lack health care coverage. Using a "whole person" approach and providing a combination of health and social care, the PASS offer an appropriately adapted response to complex health problems within a context of marked social vulnerability and contribute to reducing health inequalities. The PASS are an example of an interdisciplinary approach to health care which contrasts with the segmentary approach typical of conventional hospital departments. Operating at the interface between primary and secondary care, the PASS have the potential to become key players in developing models of patient pathways. Their presence reduces inappropriate emergency attendances and hospitalisation by offering medical care in a timely fashion, in an outpatient-type setting. The PASS can provide a resource for research into optimum models of health care, where the social context of health needs are fully recognized and inform medical treatment appropriately. According to their potential development, PASS are living labs of an innovative organizational model of care. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Representation-based user interfaces for the audiovisual library of the year 2000

NASA Astrophysics Data System (ADS)

Aigrain, Philippe; Joly, Philippe; Lepain, Philippe; Longueville, Veronique

1995-03-01

The audiovisual library of the future will be based on computerized access to digitized documents. In this communication, we address the user interface issues which will arise from this new situation. One cannot simply transfer a user interface designed for the piece by piece production of some audiovisual presentation and make it a tool for accessing full-length movies in an electronic library. One cannot take a digital sound editing tool and propose it as a means to listen to a musical recording. In our opinion, when computers are used as mediations to existing contents, document representation-based user interfaces are needed. With such user interfaces, a structured visual representation of the document contents is presented to the user, who can then manipulate it to control perception and analysis of these contents. In order to build such manipulable visual representations of audiovisual documents, one needs to automatically extract structural information from the documents contents. In this communication, we describe possible visual interfaces for various temporal media, and we propose methods for the economically feasible large scale processing of documents. The work presented is sponsored by the Bibliotheque Nationale de France: it is part of the program aiming at developing for image and sound documents an experimental counterpart to the digitized text reading workstation of this library.

HPLC & NMR-based forced degradation studies of ifosfamide: The potential of NMR in stability studies.

PubMed

Salman, D; Peron, J-M R; Goronga, T; Barton, S; Swinden, J; Nabhani-Gebara, S

2016-03-01

The aim of this study is to conduct a forced degradation study on ifosfamide under several stress conditions to investigate the robustness of the developed HPLC method. It also aims to provide further insight into the stability of ifosfamide and its degradation profile using both HPLC and NMR. Ifosfamide solutions (20mg/mL; n=15, 20mL) were stressed in triplicate by heating (70°C), under acidic (pH 1 & 4) and alkaline (pH 10 & 12) conditions. Samples were analysed periodically using HPLC and FT-NMR. Ifosfamide was most stable under weakly acidic conditions (pH 4). NMR results suggested that the mechanism of ifosfamide degradation involves the cleavage of the PN bond. For all stress conditions, HPLC was not able to detect ifosfamide degradation products that were detected by NMR. These results suggest that the developed HPLC method for ifosfamide did not detect the degradation products shown by NMR. It is possible that degradation products co-elute with ifosfamide, do not elute altogether or are not amenable to the detection method employed. Therefore, investigation of ifosfamide stability requires additional techniques that do not suffer from the aforementioned shortcomings. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Particulate contamination associated with the manipulation of drugs in glass ampules: A literature review].

PubMed

Painchart, L; Odou, P; Bussières, J-F

2018-01-01

The manipulation of drugs from glass ampules can generate particles when the ampule is broken. Several authors recommend the use of filter needle to withdraw the drug content. The aim of this study is to make an assessment of the presence of particles during the manipulation of glass ampules and to discuss the current practices. Literature review based on a search strategy (Pubmed, Google Scholar) and a summary table of available data. Analysis to evaluate the efficacy of the filtration when data are available. Eighteen articles have been included. Most of study shows the presence of particles in glass ampules. Important discrepancies reported regarding the number of particles per ampule. Analysis of data from seven studies: decrease of 83% of the total number of particles (>10μm) identified when drugs are removed with filter needle. All studies but two confirm the efficacy of filter needles. Studies show the presence of particles when drugs are removed from glass ampules. They do not allow to make a conclusion on human clinical consequences associated with the presence of particles. It is necessary to evaluate in human the risks associated with particle contamination to determine the optimal use of filter needle. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Staff accreditation in parenteral nutrition production in hospital pharmacy].

PubMed

Vrignaud, S; Le Pêcheur, V; Jouan, G; Valy, S; Clerc, M-A

2016-09-01

This work aims to provide staff accreditation methodology to harmonize and secure practices for parenteral nutrition bags preparation. The methodology used in the present study is inspired from project management and quality approach. Existing training supports were used to produce accreditation procedure and evaluation supports. We first defined abilities levels, from level 1, corresponding to accredited learning agent to level 3, corresponding to expert accredited agent. Elements assessed for accreditation are: clothing assessment either by practices audit or by microbiologic test, test bags preparation and handling assessment, bag production to assess aseptic filling for both manual or automatized method, practices audit, number of days of production, and non-conformity following. At Angers Hospital, in 2014, production staff is composed of 12 agents. Staff accreditation reveals that 2 agents achieve level 3, 8 agents achieve level 2 and 2 agents are level 1. We noted that non-conformity decreased as accreditation took place from 81 in 2009 to 0 in 2014. To date, there is no incident due to parenteral bag produced by Angers hospital for neonatal resuscitation children. Such a consistent study is essential to insure a secured nutrition parenteral production. This also provides a satisfying quality care for patients. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Prevention of infections in adults and adolescents with systemic lupus erythematosus: Guidelines for the clinical practice based on the literature and expert opinion].

PubMed

Mathian, A; Arnaud, L; Adoue, D; Agard, C; Bader-Meunier, B; Baudouin, V; Belizna, C; Bonnotte, B; Boumedine, F; Chaib, A; Chauchard, M; Chiche, L; Daugas, E; Ghali, A; Gobert, P; Gondran, G; Guettrot-Imbert, G; Hachulla, E; Hamidou, M; Haroche, J; Hervier, B; Hummel, A; Jourde-Chiche, N; Korganow, A-S; Kwon, T; Le Guern, V; Le Quellec, A; Limal, N; Magy-Bertrand, N; Marianetti-Guingel, P; Martin, T; Martin Silva, N; Meyer, O; Miyara, M; Morell-Dubois, S; Ninet, J; Pennaforte, J-L; Polomat, K; Pourrat, J; Queyrel, V; Raymond, I; Remy, P; Sacre, K; Sibilia, J; Viallard, J-F; Viau Brabant, A; Hanslik, T; Amoura, Z

2016-05-01

To develop French recommendations about the management of vaccinations, the screening of cervical cancer and the prevention of pneumocystis pneumonia in systemic lupus erythematosus (SLE). Thirty-seven experts qualified in internal medicine, rheumatology, dermatology, nephrology and pediatrics have selected recommendations from a list of proposition based on available data from the literature. For each recommendation, the level of evidence and the level of agreement among the experts were specified. Inactivated vaccines do not cause significant harm in SLE patients. Experts recommend that lupus patient should receive vaccinations accordingly to the recommendations and the schedules for the general public. Pneumococcal vaccination is recommended for all SLE patients. Influenza vaccination is recommended for immunosuppressed SLE patients. Live attenuated vaccines should be avoided in immunosuppressed patients. Yet, recent works suggest that they can be considered in mildly immunosuppressed patients. Experts have recommended a cervical cytology every year for immunosuppressed patients. No consensus was obtained for the prevention of pneumocystis pneumonia. These recommendations can be expected to improve clinical practice uniformity and, in the longer term, to optimize the management of SLE patients. Copyright © 2016 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Autisme et douleur – analyse bibliographique

PubMed Central

Dubois, Amandine; Rattaz, Cécile; Pry, René; Baghdadli, Amaria

2010-01-01

La présente analyse bibliographique a pour objectif de réaliser un bilan des travaux publiés dans le champ de la douleur et de l’autisme. L’article aborde, dans un premier temps, les études publiées concernant les modes d’expression de la douleur observés dans cette population. Différentes hypothèses permettant d’expliquer les particularités expressives des personnes avec autisme sont ensuite passées en revue : excès d’endorphines, particularités dans le traitement sensoriel, déficit sociocommunicatif. Cette analyse bibliographique aborde, pour terminer, la question de l’évaluation et de la prise en compte de la douleur chez les personnes avec autisme. Les auteurs concluent à l’absence d’homogénéité des résultats des études publiées et au besoin de poursuivre les recherches afin de parvenir à des données consensuelles sur un domaine d’étude encore peu exploité au plan scientifique. Sur un plan clinique, l’approfondissement des connaissances dans ce domaine devrait permettre de mettre au point des outils d’évaluation de la douleur et d’ainsi en assurer une meilleure prise en charge au quotidien. PMID:20808970

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ouzounian, G.

Year 2006 has been marked in France by the vote in the Parliament of the Planning Act of 28 June, 2006, concerning the sustainable management of radioactive materials and waste. This vote was the achievement of a 15 years research programme performed as required by the previous Research Law of 1991, also known as the Bataille Law, from the name of Christian Bataille, MP, who drafted it and monitored its enforcement as a member of the Parliamentary Office for Scientific and Technological Assessment (Office Parlementaire d'Evaluation des Choix Scientifiques et Techniques - OPECST). At that time a stepwise approach tomore » siting was introduced in the process. It included the study of several alternatives to the geological disposal of long lived high level radioactive waste. Those alternatives have been thoroughly studied and assessed before the Government decided to submit the bill to the Parliament. Experience has been gained not only on the scientific and technical aspects, but also in the field of decision making process, also called now governance. However, not only the results of the research programme were decisive in preparing the bill, but also of major importance were the industrial experience of ANDRA and the rigorous programme management along all those years. Main lessons learnt from the experience are given in this paper. (authors)« less

Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pulver, A.E.; Lasseter, V.K.; Wolyniec, P.

A collaboration involving four groups of investigators (Johns Hopkins University/Massachusetts Institute of Technology; Medical College of Virginia/The Health Research Board, Dublin; Institute of Psychiatry, London/University of Wales, Cardiff; Centre National de la Recherche Scientifique, Paris) was organized to confirm results suggestive of a schizophrenia susceptibility locus on chromosome 22 identified by the JHU/MIT group after a random search of the genome. Diagnostic, laboratory, and analytical reliability exercises were conducted among the groups to ensure uniformity of procedures. Data from genotyping of 3 dinucleotide repeat polymorphisms (at the loci D22S268, IL2RB, D22S307) for a combined replication sample of 256 families, eachmore » having 2 or more affected individuals with DNA, were analysed using a complex autosomal dominant model. This study provided no evidence for linkage or heterogeneity for the region 22q12-q13 under this model. We conclude that if this region confers susceptibility to schizophrenia, it must be in only a small proportion of families. Collaborative efforts to obtain large samples must continue to play an important role in the genetic search for clues to complex psychiatric disorders such as schizophrenia. 32 refs., 3 tabs.« less

On the performance of updating Stochastic Dynamic Programming policy using Ensemble Streamflow Prediction in a snow-covered region

NASA Astrophysics Data System (ADS)

Martin, A.; Pascal, C.; Leconte, R.

2014-12-01

Stochastic Dynamic Programming (SDP) is known to be an effective technique to find the optimal operating policy of hydropower systems. In order to improve the performance of SDP, this project evaluates the impact of re-updating the policy at every time step by using Ensemble Streamflow Prediction (ESP). We present a case study of the Kemano's hydropower system on the Nechako River in British Columbia, Canada. Managed by Rio Tinto Alcan (RTA), this system is subject to large streamflow volumes in spring due to important amount of snow depth during the winter season. Therefore, the operating policy should not only maximize production but also minimize the risk of flooding. The hydrological behavior of the system is simulated with CEQUEAU, a distributed and deterministic hydrological model developed by the Institut national de la recherche scientifique - Eau, Terre et Environnement (INRS-ETE) in Quebec, Canada. On each decision time step, CEQUEAU is used to generate ESP scenarios based on historical meteorological sequences and the current state of the hydrological model. These scenarios are used into the SDP to optimize the new release policy for the next time steps. This routine is then repeated over the entire simulation period. Results are compared with those obtained by using SDP on historical inflow scenarios.

Micromechanical Study of Metals

NASA Technical Reports Server (NTRS)

Velikov, P. A.; Stchapov, N. P.; Lorenz, W. F.

1945-01-01

The Institut Scientifique Experimental des Transports at Moscow established toward the end of 1925 had since its inception included in its program the study of the mechanism of plastic deformation and the problems associated with it with reference to the materials of the means of transport. Before the program thus determined upon could be carried out, it was necessary to adopt a method of research, or, more exactly, a system of such methods. Because of the modest equipment of the laboratory of the recently established institute, the choice of any particular method was determined not only by the advantages it offered but also by the resources available. As a result of a series of studies and investigations, a method was determined upon which in this paper will be denoted as the micromechanical method. The underlying basis of this method is already known. As will be seen from the description that follows, the micromechanical method is merely a combination of the micrographic study of plastic deformations with mechanical tests on small specimens. It is a well-known fact that a number of investigators have largely employed and still are employing these two procedures and have thereby obtained good results. The authors of the present paper have found it useful to combine the two methods, by making the two studies simultaneously on the sane specimen.

Associations among body size across the life course, adult height and endometriosis.

PubMed

Farland, L V; Missmer, S A; Bijon, A; Gusto, G; Gelot, A; Clavel-Chapelon, F; Mesrine, S; Boutron-Ruault, M C; Kvaskoff, M

2017-08-01

Are body size across the life course and adult height associated with endometriosis? Endometriosis is associated with lean body size during childhood, adolescence and adulthood; tall total adult height; and tall sitting height. The literature suggests that both adult body size and height are associated with endometriosis risk, but few studies have investigated the role of body size across the life course. Additionally, no study has investigated the relationships between components of height and endometriosis. We used a nested case-control design within E3N (Etude Epidémiologique auprès de femmes de l'Education Nationale), a prospective cohort of French women. Data were updated every 2-3 years through self-administered questionnaires. Odds ratios (ORs) and 95% CIs were computed using logistic regression models adjusted for a priori confounding factors. A total of 2416 endometriosis cases were reported as surgically ascertained among the 61 208 included women. The odds of endometriosis were lower among women who reported having a large versus lean body size at 8 years (P for trend = 0.003), at menarche (P for trend < 0.0001) and at ages 20-25 years (P for trend < 0.0001). Women in the highest quartiles of height had statistically significantly increased odds of endometriosis compared to those in the lowest (<158 cm) (162-164 cm: OR = 1.28, 95% CI = 1.12-1.46; ≥165 cm: OR = 1.33, 95% CI = 1.18-1.49, P for trend < 0.0001). Statistically significantly increased odds were also observed among women with a taller sitting height (OR = 1.24, 95% CI = 1.05-1.47, P for trend = 0.01). Leg length was not statistically significantly associated with endometriosis. Endometriosis cases may be prone to misclassification; however, we restricted our case definition to surgically-confirmed cases, which showed a high validation rate. Body size is based on retrospective self-report, which may be subject to recall bias. The results of this study suggest that endometriosis is positively associated with lean body size across the life course and total adult height. They also suggest that components of height are associated with endometriosis, which should be investigated further. The Mutuelle Générale de l'Education Nationale (MGEN); the European Community; the French League against Cancer (LNCC); Gustave Roussy; the French Institute of Health and Medical Research (Inserm). L.V.F. was supported by a T32 grant (#HD060454) in reproductive, perinatal and pediatric epidemiology from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Cancer Institute (3R25CA057711) National Institutes of Health. M.K. was supported by a Marie Curie Fellowship within the seventh European Community Framework Programme (#PIOF-GA-2011-302078). The authors have no conflicts of interest to declare. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

[Medico-economic evaluation of therapeutic strategies at hospital: A systematic review of French studies].

PubMed

Baudouin, A; Armoiry, X; Dussart, C

2017-05-01

Therapeutic innovation contributes to the increase of health care expenditures in France. Medico-economic evaluation has still a minor role in the decision-making for the registration of drugs and medical devices in hospitals. This study aimed to systematically review published works on medico-economic studies conducted within French hospitals. A literature review was carried out to search for medico-economic studies conducted by hospital teams on therapeutic or diagnostic strategies employed within French hospitals and published from 2010 to 2014. Quality assessment of selected studies was performed according to Drummond et al.'s checklist, which is also used within French guidelines. Of the 44 analyzed articles, methods for identification and measure of costs and results complied with guidelines in 95 % of cases. For results interpretation, compliance was 91 %. Costs discounting (29 %) and the use of sensitivity analysis to account for results uncertainty (70 %) were the parameters with the lowest compliance to guidelines. A good training of health professionals in using economic and statistic tools, and the transferability of results of medico-economic studies are essential and should be optimized to enable a broader use of medico-economic evaluation within the scope of decision-making in French hospitals. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Multiple facets of ADA2 deficiency: Vasculitis, auto-inflammatory disease and immunodeficiency: A literature review of 135 cases from literature].

PubMed

Fayand, A; Sarrabay, G; Belot, A; Hentgen, V; Kone-Paut, I; Grateau, G; Melki, I; Georgin-Lavialle, S

2018-04-01

Deficiency of adenosine deaminase 2 (DADA2) is a recently described auto-inflammatory disorder. It is an autosomal recessive inherited disease, caused by mutations in the ADA2 gene (formerly known as CECR1) encoding ADA2 enzyme. Besides its role in the purine metabolism, it has been postulated that ADA2 may act as a growth factor for endothelial cells and in the differenciation of monocytes. Thus, deficiency of ADA2 would lead to endothelial damage and a skewing of monocytes into M1 pro-inflammatory macrophage, causing DADA2 manifestations. Three core clinical features have been described: inflammatory-vascular signs, hematologic abnormalities and immunodeficiency. Clinically, patients display intermittent fever, cutaneous vascular manifestations, such as livedo, ischemic strokes, arthralgia and abdominal pain crisis. Corticosteroids and immunosuppressive agents (i.e. cyclophosphamide, azathioprine, ciclosporin, methotrexate) appear to be poorly effective. Although the mechanism has not been elucidated, anti-TNF agents have been proven efficient in DADA2 and should therefore be used as first line therapy for vasculitis. Role of anti-platelet and anticoagulant therapies in stroke-prophylaxis remains to be discussed, as those patients display a high risk of intracranial bleeding. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Refusal of care faced by case manager from elderly persons in complex situation: cross perspectives].

PubMed

Corvol, A; Balard, F; Moutel, G; Somme, D

2014-01-01

Case management is a new professional field in France. It is addressed to elderly persons living in community whose situation is regarded as particularly complex. Case managers have to assess needs and coordinate necessary services. One common criteria of complexity is refusal of care. The objective of this study is to compare the words of users with those of case managers about refusal of care, in order to understand its meaning, professionals' attitudes and ethical challenges. Two researchers have cooperated on this qualitative research: the first one, anthropologist, interviewed 19 individuals, and 11 of their caregivers. The second one, geriatrician and researcher in medical ethics, lead four focus groups gathering a total of 18 case managers. Refusal of care often is the result of the will of preserving one's identity, compromised by illness. Individuals seek control on their life. Facing this behaviour, case managers try to secure the individual, by establishing a personal relationship that respects their choices, even if care has to be delayed. Refusal of care may sometimes disclose a desire to vanish, in front of which professionals meet their own limits. To recognise an elderly person that refuses care as a unique individual who can make choices secure his identity, and allow him to change. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Cryopyrine-associated periodic syndrome: CAPS seen from adulthood].

PubMed

Koné-Paut, I

2015-04-01

Cryopyrin-associated periodic syndrome is a rare hereditary periodic fever syndrome for which, the genetic mechanism, mutation in the NLRP3 gene, has allowed to gather 3 clinical phenotypes (familial cold urticaria [FCAS], Muckle-Wells syndrome [MWS], and chronic infantile neurological cutaneous and articular syndrome [CINCA]) initially described independently, and to discover the NLRP3 inflammasome, a key receptor of the innate immunity, which regulates the interleukine-1β secretion into the mononuclear cells. The clinical manifestation of CAPS : urticaria-like skin rash, eyes redness, myalgia and sensory deafness are not specific, if considered separately, and that often leads to a wandering diagnosis through a complex medical journey including various specialists. The diagnostic delay is deleterious to patients compromising their quality of life and exposing them to neurosensory complications and renal failure by secondary amyloidosis. The paediatric onset of disease, the family history, the trigger of symptoms by the cold, and the recognition of the skin rash as neutrophilic are important clues before diagnostic confirmation by genetic testing. Interleukine-1 blockade is the only effective treatment of CAPS symptoms which often may stabilize (rarely regression) the sensory involvement and in some cases may allow the regression of secondary amyloidosis. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Machine Learning to Improve the Effectiveness of ANRS in Predicting HIV Drug Resistance.

PubMed

Singh, Yashik

2017-10-01

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is one of the major burdens of disease in developing countries, and the standard-of-care treatment includes prescribing antiretroviral drugs. However, antiretroviral drug resistance is inevitable due to selective pressure associated with the high mutation rate of HIV. Determining antiretroviral resistance can be done by phenotypic laboratory tests or by computer-based interpretation algorithms. Computer-based algorithms have been shown to have many advantages over laboratory tests. The ANRS (Agence Nationale de Recherches sur le SIDA) is regarded as a gold standard in interpreting HIV drug resistance using mutations in genomes. The aim of this study was to improve the prediction of the ANRS gold standard in predicting HIV drug resistance. A genome sequence and HIV drug resistance measures were obtained from the Stanford HIV database (http://hivdb.stanford.edu/). Feature selection was used to determine the most important mutations associated with resistance prediction. These mutations were added to the ANRS rules, and the difference in the prediction ability was measured. This study uncovered important mutations that were not associated with the original ANRS rules. On average, the ANRS algorithm was improved by 79% ± 6.6%. The positive predictive value improved by 28%, and the negative predicative value improved by 10%. The study shows that there is a significant improvement in the prediction ability of ANRS gold standard.

[Patients' intervention in a therapeutic education program dedicated to systemic lupus: definitions, setting and benefits].

PubMed

Hervier, B; Magar, Y; Allab, F; Richard, K; Neves, Y; Danjou, S; Amoura, Z; Ayçaguer, S

2015-10-01

Though recommended, participation of patients with specific expertise in therapeutic education programs (TEP) is rare. This work reports the experience of a national reference centre for rare systemic diseases. Involvement of "expert patients" (EP) has been planned from the development of a TEP dedicated to systemic lupus: patients' roles and required expertise have been defined and linked to the pedagogical tools. Such patients have been recruited during individual interviews and called to participate to specific pedagogical training. EP intervention have been evaluated by questionnaire to EP and health care providers. Three EP's functions have been identified: sharing experiences, giving "tips and tricks" and promoting dialogue. EP's interventions has been organised into a hierarchy (from sharing to co-animation). Among 298 patients enrolled in the TEP, 25 (8.4%) have been identified as possible EP. Eight of them (32%) benefited from a specific training of 12 hours. Among these patients, two (25%) regularly participate to the education sessions. For EP as well as for health care providers, EP's intervention seems beneficial (visual scale scores of 7.5 and 9.5, respectively). Though difficult to organise, EP's intervention in TEP dedicated to rare systemic diseases seems useful and would earn to be increase. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Unexplicated neuropsychiatric disorders: Do not ignore dysimmune encephalitis. A case report of a dysimmune encephalitis with anti-leucine rich glioma inactivated 1 (LGI-1) antibodies].

PubMed

Le Dault, E; Lagarde, S; Guedj, E; Dufournet, B; Rey, C; Kaphan, E; Tanguy, G; Bregigeon, M; Sagui, E; Brosset, C

2016-02-01

Anti-leucine rich glioma inactivated 1 encephalitis is a common and a treatable etiology of autoimmune encephalitis. Its diagnosis is a challenge because the initial diagnostic work-up is often normal. A 48-year-old man experienced cognitive and behavioral troubles, facio-brachial dystonic seizures and a syndrome of inappropriate antidiuretic hormone secretion. First line tests excluded infectious, neoplastic, systemic inflammatory, endrocrine or toxic etiologies. Cerebral (18)Fluoro-desoxy-glucose (FDG) position emission tomography and research of specific antibodies in cerebro-spinal fluid and serum led to diagnose an anti-leucine rich glioma inactivated 1 encephalitis. Intravenous immunoglobulins and corticosteroids were partially effective. Cyclophosphamid permitted a good recovery. In the presence of acute neuropsychiatric disorders with a negative etiologic research, physician should think about dysimmune encephalitis. Facio-brachial dystonic seizures and syndrome of inappropriate antidiuretic hormone secretion are highly evocative of anti-leucine rich glioma inactivated 1 encephalitis. The diagnosis needs specific diagnostic tests (cerebral (18)FDG position emission tomography and antibodies research in cerebro-spinal fluid and in serum), after the exclusion of alternative diagnoses. Extensive and repeated diagnostic work-up for neoplasia is required. Immunosupressive therapies are effective in most cases. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

["Placebo effect", from personal convictions to collective representations: A psychosocial reading of a pharmacodynamic phenomenon].

PubMed

Balez, R; Couturaud, F; Touffet, L

2015-11-01

After starting with a brief historical account of the placebo effect organized around the elaboration of clinical trials and around sham therapy as a method, we will offer a psychosocial point of view on the placebo phenomenon. The placebo effect is at the heart of medicine and particularly of therapeutic trials from theoretical research on a drug to its acceptance and its use in every-day clinical practice. The placebo effect intermingles biology, relationships and the context of therapeutic interactions. This type of phenomenon originates as much from biology as from human psychology. Our article puts more precisely into question the part that psychology has in the placebo phenomenon and suggests a chart to address it. This chart refers both to the pharmacodynamic effect given to drugs in a subjective way, and to the collective representations and social interactions depending on them. What can we say about the psychosociological dimensions of the placebo effect? How is it possible to organize the scope of these dimensions to base systematic studies on them in the field of clinical trials? We try to give elements of response to these questions by suggesting the study of the placebo effect as an original field of study by necessarily mobilizing both health sciences and the human and social sciences. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[The plague: An overview and hot topics].

PubMed

Galy, A; Loubet, P; Peiffer-Smadja, N; Yazdanpanah, Y

2018-04-05

Plague is a bacterial zoonosis caused by Yersinia pestis, usually found in fleas and small rodents that constitute the reservoir of the disease. It is transmitted to humans by flea bite, contact with rodents or inhalation of infected droplets. There are three clinical forms: bubonic plague, pulmonary plague and septicemic plague. The usual presentation is a flu-like syndrome possibly accompanied by an inflammatory lymphadenopathy which appears after 1 to 7days of incubation. Bubonic plague has a case fatality rate of about 50% while other forms of plague are almost always fatal without treatment. Diagnosis can be confirmed by usual bacteriological techniques (Gram examination, culture) but also by serological examination, use of rapid diagnostic tests or PCR. Although aminoglycosides are traditionally regarded as the most effective treatment, fluoroquinolones or cyclins are currently recommended in France. Plague is one of the re-emerging diseases according to the WHO and Madagascar suffered in 2017 the most important plague epidemic of the 21st century with more than 2000 cases and 200 deaths. Peru and the Democratic Republic of Congo are also considered endemic areas. Public health measures and a relentless fight against poverty are the cornerstone of the control of the disease. Vaccine improvement in endemic areas may also play an important role. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Electronic cigarettes: A therapeutic tool, a social phenomenon or a business?].

PubMed

Berlin, I

2015-06-01

Smoking is the first avoidable cause of morbidity and mortality. It is estimated that there were around 14 million smokers in France in 2012 and that smoking results in 70,000 deaths per year. All types of interventions reducing with efficacy the incidence and prevalence of smoking are to consider in prolonging life expectancy. Electronic cigarettes (e.cig.) are a social phenomenon but they also are a system delivering pharmacologically active substances; their use concerns today several millions of individuals in France. By this fact, it became important for clinical practitioners to acquire some knowledge about e. cig. Most of the e.cig. contains nicotine, thus, e.cig. are now called in the medical literature as electronic nicotine delivery system (ENDS). It is highly plausible that ENDS, which are, as of today, consumer products and not health products, deliver nicotine with a good bioavailability and could, if largely used, help to reduce smoking prevalence. However, because of current lack of regulations, as of today, the risk/benefit ratio of ENDS as an aid to help smokers quit and their adverse effect profile cannot be established. It is of public health responsibility to promote evidence based knowledge about e.cig. to know with confidence their risk/benefit ratio. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Medication errors with concentrated potassium intravenous solutions: Data of the literature, context and prevention].

PubMed

Charpiat, B; Magdinier, C; Leboucher, G; Aubrun, F

2016-01-01

Accidental direct intravenous injection of a concentrated solution of potassium often leads to patient death. In France, recommendations of healthcare agencies to prevent such accidents cover only preparation and intravenous infusion conditions. Accidents continue to occur in French hospitals. These facts demonstrate that these recommendations are insufficient and ineffective to prevent such deaths, especially those occurring during a catheter flushing. This article reviews the measures able to reduce the number of accidents. Countries which removed concentrated ampoules from ward stocks observed a decrease of the number of accidental deaths. This withdrawal, recommended by the World Health Organization, is now part of standards in studies aimed at determining the safety of care in hospitals. However, removal alone is insufficient to eliminate the risk. The combination with other measures should be considered. These measures are the provision of a combination of diluted intravenous ready to use solutions, the promotion of the oral route with tablets and oral solutions for potassium replenishment and to make available products with safeguards to prevent single shot intravenous injection. Studies aimed at determining the consequences on preventing concentrated potassium accidents of a widespread distribution of isotonic sodium chloride pre-filled ready-to-use syringes for catheter flushing should be performed. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

A French-speaking speech-language pathology program in West Africa: transfer of training between Minority and Majority World countries.

PubMed

Topouzkhanian, Sylvia; Mijiyawa, Moustafa

2013-02-01

In West Africa, as in Majority World countries, people with a communication disability are generally cut-off from the normal development process. A long-term involvement of two partners (Orthophonistes du Monde and Handicap International) allowed the implementation in 2003 of the first speech-language pathology qualifying course in West Africa, within the Ecole Nationale des Auxiliaires Medicaux (ENAM, National School for Medical Auxiliaries) in Lome, Togo. It is a 3-year basic training (after the baccalaureate) in the only academic training centre for medical assistants in Togo. This department has a regional purpose and aims at training French-speaking African students. French speech-language pathology lecturers had to adapt their courses to the local realities they discovered in Togo. It was important to introduce and develop knowledge and skills in the students' system of reference. African speech-language pathologists have to face many challenges: creating an African speech and language therapy, introducing language disorders and their possible cure by means other than traditional therapies, and adapting all the evaluation tests and tools for speech-language pathology to each country, each culture, and each language. Creating an African speech-language pathology profession (according to its own standards) with a real influence in West Africa opens great opportunities for schooling and social and occupational integration of people with communication disabilities.

Benefits of pharmacist-led flu vaccination services in community pharmacy.

PubMed

Kirkdale, C L; Nebout, G; Megerlin, F; Thornley, T

2017-01-01

Seasonal influenza is a major cause of excess winter deaths and increased hospital admissions. There is a high level of economic burden associated with the infection. Although vaccination targets have been set to tackle this international issue, many countries struggle to reach these coverage targets for their at-risk populations using traditional delivery methods. Traditional providers include family doctors and nurses; however, pharmacist-led influenza vaccination has become a more commonly utilised aid to support vaccination targets. Community pharmacies are convenient and widely accessible and evaluations consistently demonstrate that patients are satisfied with pharmacist-led vaccinations. Allowing community pharmacists to administer influenza vaccination as an alternative option for delivery helps to increase the coverage rate of vaccination. In addition, commissioning community pharmacists to provide this service has been shown to contribute to achieving targets for those at-risk. Pharmacist-led influenza vaccination services can create value for payors and reduce pressure on health systems. This review aims to demonstrate the success of pharmacy-led influenza vaccinations, and the impact it has had in driving up immunisation rates within other countries. Experiences of countries such as England, Portugal and the United States provide evidence to demonstrate the benefit to both the patient and the health system. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Tetanus risk assessment in the older outpatients: Usefulness of the "Tétanos Quick Stick ®"?].

PubMed

Nicolaï, D; Farcet, A; Molines, C; Delalande, G; Retornaz, F

2015-05-01

Tetanus is a serious disease, which could be potentially lethal. All cases are observed in patients inadequately immunized. The immunochromatographic tests (including Tetanos quick Stick(®) [TQS]) have demonstrated their efficiency in emergency setting. The aim of our study was to assess the usefulness of these tests in elderly outpatients seen in ambulatory settings. This prospective study included patients aged 65 years and over who presented to the outpatients' clinic of the Gerontologic Departmental Center (Marseille). A TQS and a self-administered questionnaire to assess risk factors for tetanus were performed. One hundred and twenty-two patients were studied. The prevalence of positive TQS was 66%. Patients have an average of 2.5 risk factors for tetanus. Negative TQS was observed in 35% of patients who had seen their general practitioner for a wound during the previous year. Elderly patients accumulate several risk factors regardless of age and lifestyle. While physicians are familiar with the vaccine recommendations, they are often faced with the difficulty of assessing patient's status based only on the patient's interview, which is frequently not reliable. The implementation of immunochromatographic tests in general practice could help physicians in the management of patients at risk for tetanus. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Glass ceiling for women in academic medicine in France].

PubMed

Rosso, C; Leger, A; Steichen, O

2018-06-03

To determine whether career development in academic medicine is more difficult for women than for men, and, if any, the nature and level of barriers to this progression. Extraction of full-time medical staff in a Parisian hospital group, through the SIGAPS platform; an online questionnaire survey of career choices and barriers experienced by full-time male and female physicians. The study population comprises 181 hospital practitioners and 141 academic physicians (49 associate professors and 92 full professors). Women represent 49% of the medical staff but 15% of full professors. This underrepresentation of women is more important among intensivists/anesthesiologists than technique-based specialists (such as radiologists, biologists…). There is no difference in scientific output, marital status and parenthood between women and men. On the other hand, there is a difference in attitudes highlighted by the EVAR risk-taking scale as well as in the burden of familial involvement and the prejudices felt by women during the academic selection process. The glass ceiling exists in one of the largest French hospital group. Career development principles promote merit, but should decrease the benefit of "masculine" attitudes in the competition for academic positions. Academic selection criteria should evolve to limit the disadvantage of women related to deeper familial involvement and less competitive strategies and risk-taking attitudes. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Description of the mental processes occurring during clinical reasoning].

PubMed

Pottier, P; Planchon, B

2011-06-01

Clinical reasoning is a highly complex system with multiple inter-dependent mental activities. Gaining a better understanding of those cognitive processes has two practical implications: for physicians, being able to analyse their own reasoning method may prove to be helpful in diagnostic dead end; for medical teachers, identifying problem-solving strategies used by medical students may foster an appropriate individual feed-back aiming at improving their clinical reasoning skills. On the basis of a detailed literature review, the main diagnostic strategies and their related pattern of mental processes are described and illustrated with a concrete example, going from the patient's complaint to the chosen solution. Inductive, abductive and deductive diagnostic approaches are detailed. Different strategies for collecting data (exhaustive or oriented) and for problem-building are described. The place of problem solving strategies such as pattern-recognition, scheme inductive process, using of clinical script, syndrome grouping and mental hypotheses test is considered. This work aims at breaking up mental activities in process within clinical reasoning reminding that expert reasoning is characterised by the ability to use and structure the whole of these activities in a coherent system, using combined strategies in order to guarantee a better accuracy of their diagnosis. Copyright © 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Forensic entomology: implementing quality assurance for expertise work.

PubMed

Gaudry, Emmanuel; Dourel, Laurent

2013-09-01

The Department of Forensic Entomology (Institut de Recherche Criminelle de la Gendarmerie Nationale, France) was accredited by the French Committee of Accreditation (Cofrac's Healthcare section) in October 2007 on the basis of NF EN ISO/CEI 17025 standard. It was the first accreditation in this specific field of forensic sciences in France and in Europe. The present paper introduces the accreditation process in forensic entomology (FE) through the experience of the Department of Forensic Entomology. Based upon the identification of necrophagous insects and the study of their biology, FE must, as any other expertise work in forensic sciences, demonstrate integrity and good working practice to satisfy both the courts and the scientific community. FE does not, strictly speaking, follow an analytical method. This could explain why, to make up for a lack of appropriate quality reference, a specific documentation was drafted and written by the staff of the Department of Forensic Entomology in order to define working methods complying with quality standards (testing methods). A quality assurance system is laborious to set up and maintain and can be perceived as complex, time-consuming and never-ending. However, a survey performed in 2011 revealed that the accreditation process in the frame of expertise work has led to new well-defined working habits, based on an effort at transparency. It also requires constant questioning and a proactive approach, both profitable for customers (magistrates, investigators) and analysts (forensic entomologists).

Art & Astronomie - impressions celestes

NASA Astrophysics Data System (ADS)

Nazé, Yaël

2015-10-01

Ce livre revisite l'histoire de l'art dans ce qu'elle a de plus universel : son rapport au ciel. De l'Orient à l'Occident, de l'Antiquité à l'époque contemporaine, du classique au plus inattendu, il crée un espace singulier où se mêlent art et science, un musée imaginaire croisant sensibilité intime et compréhension du Cosmos, un jeu sans cesse réinventé...; car il n'y a pas une seule manière de regarder les étoiles. Bien sûr, le ciel possède un énorme pouvoir évocateur, une force inspiratrice à nulle autre pareille, mais l'inspiration n'est pas la seule des relations entre l'art et l'astronomie. En effet, les artistes peuvent apporter leur grain de sel aux révolutions scientifiques, tandis que l'astronomie peut aider à comprendre certaines œuvres. Avec près de 600 illustrations, cet ouvrage n'a pas pour but d'égrener la liste exhaustive des représentations de ciel étoilé, clair de lune, ambiance crépusculaire ou soleil de midi, mais plutôt d'aborder les multiples relations entre l'art et la science. Il s'agit d'une invitation à un voyage aux frontières mouvantes et incertaines des plus belles réalisations de l'esprit humain.

“Big Data” Teen Astronomy Cafes at NOAO

NASA Astrophysics Data System (ADS)

Pompea, Stephen; Walker, Constance E.

2018-01-01

The National Optical Astronomy Observatory has designed and implemented a prototype educational program designed to test and understand best practices with high school students to promote an understanding of modern astronomy research with its emphasis on large data sets, data tools, and visualization tools. This program, designed to cultivate the interest of talented youth in astronomy, is based on a teen science café model developed at Los Alamos as the Café Scientifique New Mexico. In our program, we provide a free, fun way for teens to explore current research topics in astronomy on Saturday mornings at the NOAO headquarters. The program encourages stimulating conversations with astronomers in an informal and relaxed setting, with free food of course. The café is organized through a leadership team of local high school students and recruits students from all parts of the greater Tucson area. The high school students who attend have the opportunity to interact with expert astronomers working with large astronomical data sets on topics such as killer asteroids, the birth and death of stars, colliding galaxies, the structure of the universe, gravitational waves, gravitational lensing, dark energy, and dark matter. The students also have the opportunity to explore astronomical data sets and data tools using computers provided by the program. The program may serve as a model for educational outreach for the 40+ institutions involved in the LSST.

Probability distribution of financial returns in a model of multiplicative Brownian motion with stochastic diffusion coefficient

NASA Astrophysics Data System (ADS)

Silva, Antonio

2005-03-01

It is well-known that the mathematical theory of Brownian motion was first developed in the Ph. D. thesis of Louis Bachelier for the French stock market before Einstein [1]. In Ref. [2] we studied the so-called Heston model, where the stock-price dynamics is governed by multiplicative Brownian motion with stochastic diffusion coefficient. We solved the corresponding Fokker-Planck equation exactly and found an analytic formula for the time-dependent probability distribution of stock price changes (returns). The formula interpolates between the exponential (tent-shaped) distribution for short time lags and the Gaussian (parabolic) distribution for long time lags. The theoretical formula agrees very well with the actual stock-market data ranging from the Dow-Jones index [2] to individual companies [3], such as Microsoft, Intel, etc. [] [1] Louis Bachelier, ``Th'eorie de la sp'eculation,'' Annales Scientifiques de l''Ecole Normale Sup'erieure, III-17:21-86 (1900).[] [2] A. A. Dragulescu and V. M. Yakovenko, ``Probability distribution of returns in the Heston model with stochastic volatility,'' Quantitative Finance 2, 443--453 (2002); Erratum 3, C15 (2003). [cond-mat/0203046] [] [3] A. C. Silva, R. E. Prange, and V. M. Yakovenko, ``Exponential distribution of financial returns at mesoscopic time lags: a new stylized fact,'' Physica A 344, 227--235 (2004). [cond-mat/0401225

Apport des neutrons à l'analyse structurale des composés partiellement désordonnés

NASA Astrophysics Data System (ADS)

Cousson, A.

2003-02-01

La cristallographie est un outil extrêmement puissant qui pourrait être utilisé par de nombreux scientifiques dont les sujets de recherche sont en fait très éloignés. L'évolution des techniques ces dernières années a relégué par exemple la cristallographie des rayons X des petites molécules à un rôle mineur, un rôle de service. Certains ont même le sentiment semble-t-il que toutes les connaissances sont contenues dans de multiples logiciels capables par eux-mêmes de conduire une analyse structurale à un résultat correct unique. Il est souhaitable que chacun soit capable de réaliser l'étude structurale du composé qui l'intéresse et bien entendu nécessaire de comprendre ce que l'on fait, la qualité des résultats et leur analyse en dépend. L'objet de cette présentation est de montrer l'apport spécifique de la diffraction de neutrons sur monocristaux à l'étude du désordre, en particulier des atomes d'hydrogène, et ses conséquences sur la compréhension des propriétés physiques, à partir de développements et d'exemples récents.

Glorious Eclipses

NASA Astrophysics Data System (ADS)

Brunier, Serge; Luminet, Jean-Pierre

2000-12-01

Stargazers who may have missed the last total solar eclipse of the 20th century this past summer have just been given another chance to observe this "once in a lifetime" occurrence. Inside Glorious Eclipses they will find startling images and rich personal accounts that fully capture this event and other recent eclipses. The book will also insure that readers will not miss another eclipse in the next 60 years! Specially designed in a beautiful, large format, the volume portrays eclipses of all kinds--lunar, solar, and those occurring elsewhere in the Solar System and beyond. Brunier and Luminet have gathered together all aspects of eclipses, and carefully selected a host of lavish images. The authors detail the history of eclipses, the celestial mechanics involved, their observation, and scientific interest. Personal accounts of recent eclipses are also included as well as all relevant information about forthcoming eclipses up to 2060. Complete with NASA maps and data, Glorious Eclipses is the ultimate source for all those interested in these remarkable (and rare) celestial events. Serge Brunier is chief editor of the journal Ciel et Espace, a photo-journalist, and the author of many nonfiction books aimed at both specialists and the general public. Jean-Pierre Luminet is an astrophysicist at the Paris-Meudon Observatory and director of research at the Centre pour la Recherche Scientifique. He is the author of many popular astronomy books, including Black Holes (Cambridge University Press, 1992).

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis.

PubMed

Desdoits-Lethimonier, C; Lesné, L; Gaudriault, P; Zalko, D; Antignac, J P; Deceuninck, Y; Platel, C; Dejucq-Rainsford, N; Mazaud-Guittot, S; Jégou, B

2017-07-01

Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB) and bisphenol A diglycidyl ether (BADGE) at 10-9-10-5 M for 24 or 48 h. Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase three immunohistochemistry), and the levels of testosterone, INSL3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). A significant dose-dependent inhibition was found between testosterone levels measured in the culture medium and concentrations of BPA (P = 0.00778 at 24 h and P = 0.0291 at 48 h), BPE (P = 0.039) and BPF (P = 0.00663). The observed BPA and BPA-A-induced inhibition of testosterone production varied according to duration of exposure and BPA/BPA-A concentrations. BPA (10-9 M; P < 0.05), BPB (10-9 M; P < 0.05), BPS (10-9 and 10-8 M; P < 0.05) and BADGE (10-5 M; P < 0.05) increased Leydig cell INSL3 production. By contrast, BPE dose dependently inhibited INSL3 (P = 0.0372). Conversely, Sertoli cell function (inhibin B) and germ cell viability were not significantly affected by either bisphenols. N/A. Environmental compounds cannot be deliberately administered to men, justifying the use of an ex vivo approach. A relatively low number of testes samples were available for analysis (n = 3, except for testosterone secretion with n = 5). The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis. This study was funded by Inserm (Institut National de la Santé et de la Recherche Médicale), EHESP-School of Public Health, University of Rennes1, by grants from the Agence Nationale de la Recherche (ANR; grant#ANR-13-CESA-0012-03 NEWPLAST) and Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail (ANSES; grant#EST-2010/2/046 (BPATESTIS)). All authors declare they have no current or potential competing financial interests. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Obscured and powerful AGN and starburst activities at z ~ 3.5

NASA Astrophysics Data System (ADS)

Polletta, M.; Omont, A.; Berta, S.; Bergeron, J.; Stalin, C. S.; Petitjean, P.; Giorgetti, M.; Trinchieri, G.; Srianand, R.; McCracken, H. J.; Pei, Y.; Dannerbauer, H.

2008-12-01

Aims: Short phases of coeval powerful starburst and AGN activity during the lifetimes of the most massive galaxies are predicted by various models of galaxy formation and evolution. In spite of their recurrence and high luminosity, such events are rarely observed. Finding such systems, understanding their nature, and constraining their number density can provide key constraints to galaxy evolutionary models and insights into the interplay between starburst and AGN activities. Methods: We report the discovery of two sources at z=3.867 and z=3.427 that exhibit both powerful starburst and AGN activities. They benefit from multi-wavelength data from radio to X rays from the CFHTLS-D1/SWIRE/XMDS surveys. Follow-up optical and near-infrared spectroscopy, and millimeter IRAM/MAMBO observations are also available. We performed a multi-wavelength analysis of their spectral energy distributions with the aim of understanding the origin of their emission and constraining their luminosities. A comparison with other composite systems at similar redshifts from the literature is also presented. Results: The AGN and starburst bolometric luminosities are 1013 L⊙. The AGN emission dominates at X ray, optical, mid-infrared wavelengths, and probably also in the radio. The starburst emission dominates in the far-infrared. The estimated star formation rates range from 500 to 3000 M⊙/yr. The AGN near-infrared and X ray emissions are heavily obscured in both sources with an estimated dust extinction {A_V} ≥ 4, and Compton-thick gas column densities. The two sources are the most obscured and most luminous AGNs detected at millimeter wavelengths currently known. Conclusions: The sources presented in this work are heavily obscured QSOs, but their properties are not fully explained by the standard AGN unification model. In one source, the ultraviolet and optical spectra suggest the presence of outflowing gas and shocks, and both sources show emission from hot dust, most likely in the vicinity of the nucleus. Evidence of moderate, AGN-driven radio activity is also found in both sources. Based on the estimated stellar and black hole masses, the two sources lie on the local M_BH{-}M_bulge relation. To remain on this relation as they evolve, their star formation rate has to decrease or stop. Our results support evolutionary models that invoke radio feedback such as the star formation quenching mechanism, and suggest that such a mechanism might play a major role also in powerful AGNs. This paper makes use of observations collected at the European Southern Observatory, Chile, ESO program No. 079.A-0522(A), and at the IRAM 30 m-Telescope. IRAM is funded by the Centre National de la Recherche Scientifique (France), the Max-Planck Gesellschaft (Germany), and the Instituto Geografico Nacional (Spain). Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. This work is based in part on data products produced at TERAPIX and the Canadian Astronomy Data Centre as part of the Canada-France-Hawaii Telescope Legacy Survey, a collaborative project of NRC and CNRS.

Detection of atmospheric velocity fields in A-type stars

NASA Astrophysics Data System (ADS)

Landstreet, J. D.

1998-10-01

High signal-to-noise spectra with spectral resolution of more than 10(5) have been obtained of one normal B9.5V, one normal A1V, two Am stars, and two HgMn B stars having v sin i less than 6 km s(-1) . These spectra are modeled with LTE line profile synthesis to test the extent to which the spectrum of each star can be modeled correctly with a single set of parameters T_e, log g, chemical abundances, v sin i, and (depth-independent) microturbulent velocity xi . The answer to this question is important for abundance analysis of A and B stars; if conventional line synthesis does not reproduce the line profiles observed in stars of small v sin i, results obtained from such analysis are not likely to be very precise. The comparison of models with observations is then used to search for direct evidence of atmospheric motions, including line-strength dependent broadening, line core shape, and line asymmetries, in order to study how the microturbulence derived from abundance analysis is related to more direct evidence of atmospheric velocity fields. It is found for the three stars with 12,000 >= T_e >= 10,200 K (the normal star 21 Peg and the two HgMn stars 53 Tau and HD 193452) that xi is less than 1 km s(-1) , and line profiles are reproduced accurately by the synthesis with a single set of parameters. The slightly cooler (T_e ~ 9800 K) star HD 72660 has only a slightly stronger surface convective layer than the hotter stars, but for this star xi ~ 2.2 km s(-1) . Strong spectral lines all show significant asymmetry, with the blue line wing deeper than the red wing, and have line bisectors which have curvature towards the blue with a span of about 0.5 to 1.0 km s(-1) . A single model fits all lines satisfactorily. The two Am stars (HD 108642 and 32 Aqr), with T_e ~ 8000 K, are found to have much larger values of xi (4 to 5 km s(-1) ). The strong spectral lines of these two stars are extremely asymmetric, with depressed blue wings, and the bisectors have spans of order 3 km s(-1) . No consistent fit to all lines can be found with a single model of the type used here. It is concluded (a) that classical LTE line synthesis is able to reproduce with considerable accuracy the line profiles of late B and early A stars with T_e above about 9500 K, but that the LTE model with depth-independent microturbulence provides a very poor approximation for cooler A stars, (b) that curve-of-growth microturbulent velocities in A stars are related to directly detectable atmospheric velocity fields, and (c) that the discrepancies between calculated and observed line profiles in stars with temperatures in the vicinity of 8000 K are so large that abundances derived mainly from saturated lines may well contain significant errors. As a by-product, laboratory gf values for Fe II between 3800 and 5300 Angstroms have been combined to form a set of data optimized for internal consistency of the gf values. Based on observations obtained with the Canada-France-Hawaii telescope, operated by the National Research Council of Canada, the Centre National de Recherche Scientifique of France, and the University of Hawaii, and with the 1.52-m telescope of the Observatoire de Haute Provence, operated by the Centre National de Recherche Scientifique of France.

The Teen Science Café Network

NASA Astrophysics Data System (ADS)

Hall, M.; Mayhew, M. A.

2013-12-01

The 'Teen Cafè' phenomenon grew out of an NSF-funded experiment to bring the Cafè Scientifique model for engagement of the public with science and scientists to high school teenagers. Cafè Scientifique New Mexico (cafènm.org), now in its seventh year, has proven highly popular with high school teens for much the same reason as for adult Cafè programs: the blend of socializing in an attractive venue and interaction with a scientist on an interesting science topic. Teen Cafés also include exploration of the topic with hands-on activities. The success of the model has led to the creation of the national Teen Science Cafè Network (teensciencecafe.org. This first year of the new program, four 'Founding Members' of the Network-- in Florida, Colorado, North Carolina, and the St. Louis, Missouri region--started up Teen Cafè programs. Each applied the model with a unique flair appropriate to local institutions and demographics. Each Member in the Network runs Cafès in multiple local venues. We are now gearing up for our second year, and the Network is growing. Our Teen Cafè topics have covered a very wide range, from belly-button biodiversity to cyber-security to patterns of mega-earthquakes to a day in the life of a teen dolphin to corals on acid to emergency room medicine to alternative fuel cars. Presenters have come from a great variety of local institutions. Though they are popular with teens because they are fun and interesting, our evaluations have demonstrated that the programs are having a significant impact on participating teens' understanding of the nature of science, the work that scientists do, and the importance of science to their daily lives. We are also having success in training scientists to communicate effectively with this public audience. Presenters report strong satisfaction with their resulting quality of science communication. A surprising number have reported that their experience with the program has led them to think in a new way about the significance of their own research and how best to communicate it. In addition to Members who offer Teen Cafés, we have Affiliate Organizations, including professional societies and research centers, which are actively helping us introduce the Teen Science Café model to their membership. Rather than being a collection of static, independent entities, Network Members and Affiliate Organizations are part of a dynamic network, a community of practice with active sharing of lessons learned, ideas for Café topics and formats, professional development in communicating with the public, expertise in social media, and many other resources. We want the Network as a whole to be much greater than the sum of its parts. To ensure the integrity of the Network, we are exploring strategies for effective growth, mechanisms for continual professional development for Café leaders, and collaborative approaches to sustainability. Any organization wishing to start a Teen Cafè can do so by registering on the Teen Science Café Network website and agreeing to adhere to five 'Core Design Principles.' We have resources to help others start a Teen Café, as it is part of the ethic of the Network that existing Members will actively help new Members start and successfully run a Teen Café program.

Préface

NASA Astrophysics Data System (ADS)

Schober, Helmut; Fischer, Henry; Leclercq-Hugeux, Françoise

2003-09-01

L'École Thématique “Structure et Dynamique des Systèmes Désordonnés” [1] s'inscrit dans le cadre des écoles organisées sous l'impulsion de la Société Française de la Neutronique (SFN). Elle s'est deroulée en mai 2002 sur la Presqu'île de Giens (Var) en première partie des 11émes Journées de la Diffusion Neutronique. L'Édition de ces cours constitue ainsi le cinquième ouvrage introduisant les techniques neutroniques et leurs apports à differentes thématiques [2]. Le désordre est un facteur déterminant pour pratiquement toutes les propriétés des matériaux. Il est inhérent dans les matériaux amorphes ou liquides, mais il détermine également les propriétés mécaniques et électroniques d'autres composés d'importance technologique comme les matériaux métalliques, dont l'aspect “désordonné” est moins évident. Le désordre enfin joue un rôle essentiel dans tout ce que touche à la vie. En fait, il est difficile d'imaginer des systèmes, à part quelques exceptions rares comme l'hélium ou le silicium de haute pureté, où il n'y ait pas de désordre. En dehors de cet aspect pratique, la description scientifique du désordre atomique pose toujours des problèmes fondamentaux faute de concepts pertinents. Une des tâches importantes du scientifique ou de l'ingenieur est de préciser quel genre de désordre existe à une échelle d'espace et de temps donnée. Un materiau peut très bien être homogène à l'échelle atomique et présenter des défauts ou des hétrogéneité visibles à l'œil et inversement. De même, un système désordonné à un instant donné, peut apparaître ordonné si on moyenne dans le temps. Les techniques de diffusion des neutrons sont idéales pour aborder ces questions. Les neutrons sondent directement les noyaux et ont à la fois des longueurs d'ondes proches des distances inter atomiques et des énergies avoisinant celles des excitations élémentaires de la matière condensée. Ils permettent ainsi une observation directe et non-destructive des positions et des mouvements atomiques. La gamme des distances et des temps sondés par les neutrons autorisent aussi bien de suivre le mouvement des atomes à l'échelle inter atomique que l'évolution d'une structure soit mésoscopique soit macroscopique sur des temps de moins d'une picoseconde à plusieurs heures. La gamme des techniques de diffusion utilisées pour couvrir un tel champ d'application est naturellement très large : différents types de diffractomètres permettent des études de structure atomique trés pointue et résolue dans le temps. Les spectromètres nous donnent accès à la dynamique d'une dizaine de femto- à plusieurs nanosecondes. La diffusion aux petits angles, la reflectomètrie et finalement la tomographie nous permettent de regarder la structure et la dynamique d'objets plus grands. Il était illusoire de prétendre couvrir la totalité des systèmes désordonnés et l'ensemble des techniques de diffusion neutronique pertinentes au cours d'une école de 3 jours. Nous avons donc été amené à nous concentrer sur les liquides, les verres, les cristaux plastiques et les polymères. Ce choix s'est imposé par le souhait d'introduire les concepts de base, en acceptant de sacrifier certains domaines d'applications. Il va de soi que l'étude approfondie de systèmes mettant en jeu plusieurs échelles de distance (structure moléculaire, portée des corrélations entre les molécules) et de temps (relaxations caractéristiques des divers phenomènes dynamiques selon leur extension spatiale) implique une pluralité de techniques expérimentales, complémentaires des différentes techniques neutroniques disponibles. Un des objectifs de cette école etait donc de préciser les domaines de pertinence des différentes techniques neutroniques disponibles en en situant la complémentarité avec d'autres approches instrumentales (diffraction des rayons X, EXAFS, RMN, etc.). Enfin la confrontation avec les résultats obtenus par simulation et modélisation numérique est essentielle à la compréhension des processus élémentaires dans ces systèmes complexes. En première partie de cet ouvrage, on trouvera une description géntrale des systèmes désordonnés et une introduction aux techniques de diffusion de neutrons. Pour la partie concernant la structure, une revue des techniques de diffraction est suivie par des applications à des systèmes de complexité croissante (liquides métalliques simples, alliages liquides, semiconducteurs fondus, solutions aqueuses, verres d'oxydes). L'apport des méthodes de variation de longueur de diffusion (substitution isotopique pour les mesures aux neutrons, diffusion anomale des rayons X ou combinaison de ces deux techniques) permet la détermination des facteurs de structures partiels. Pour la dynamique, on a privilégié une approche introduisant progressivement le désordre en passant des solides aux liquides. Le concept de diffusion puis les particularités dynamiques des verres sont ensuite présentés et illustrés par des exemples concrets. Enfin la dernière partie est consacrée à la simulation numérique des propriétés dynamiques des verres et des liquides et à la modélisation de la structure par méthode de Monte Carlo inverse (RMC) à partir de l'ensemble des données expérimentales existant pour un système donné. La communauté française a joué un rôle important dans le développement des techniques neutroniques dédites à l'étude des systèmes désordonnés et y a acquis une competence reconnue. Nous avons essayé, dans cet ouvrage, de privilégier les aspects pédagogiques des cours, pour les rendre accessibles aux scientifiques francophones non spécialistes en diffusion des neutrons. Nous saluons ici l'effort de rédaction, en langue française, des différents intervenants et souhaitons que cet ouvrage puisse participer à la formation et au renouvellement de la communauté neutronique française. Helmut Schober et Henry Fischer (Editeurs scientifiques) Françoise Leclercq-Hugeux (Présidente de la SFN)

[Simulation-based learning and internal medicine: Opportunities and current perspectives for a national harmonized program].

PubMed

Galland, J; Abbara, S; Terrier, B; Samson, M; Tesnières, A; Fournier, J P; Braun, M

2018-06-01

Simulation-based learning (SBL) is developing rapidly in France and the question of its use in the teaching of internal medicine (IM) is essential. While HAS encourages its integration into medical education, French Young Internists (AJI) set up a working group to reflect on the added-value of this tool in our specialty. Different sorts of SBL exist: human, synthetic and electronic. It enables student to acquire and evaluate technical skills (strengths, invasive procedures, etc.) and non-technical skills (relational, reasoning…). The debriefing that follows the simulation session is an essential time in pedagogical terms. It enables the acquisition of knowledge by encouraging the students' reflection to reshape their reasoning patterns by self-correcting. IM interns are supportive of its use. The simulation would allow young internists to acquire skills specific to our specialty such as certain gestures, complex consulting management, the synthesis of difficult clinical cases. SBL remains confronted with human and financial cost issues. The budgets allocated to the development and maintenance of simulation centres are uneven, making the supply of training unequal on the territory. Simulation sessions are time-consuming and require teacher training. Are faculties ready to train and invest their time in simulation, even though the studies do not allow us to conclude on its pedagogical validity? Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Microwave freeze-thaw technique of injectable drugs. A review from 1980 to 2014.

PubMed

Hecq, J-D; Godet, M; Jamart, J; Galanti, L

2015-11-01

Microwave freeze-thaw treatment (MFTT) of injectable drugs can support the development of centralized intravenous admixtures services (CIVAS). The aim of the review is to collect information and results about this method. A systematic review of the scientific literature about injectable drug stability studies was performed. The data are presented in a table and describe name of the drug, producer, final concentration, temperature and time of freezing storage, type of microwave oven, thawing power, method of dosage and results after treatment or final long-term storage at 5±3 °C. From 1980 to 2014, 59 drugs were studied by MFTT and the results were presented in 49 publications. Forty papers were presented by 8 teams (2 to 18 by team). The temperatures of freezing storage vary from -70 °C to -10 °C, the time storage from 4 hours to 12 months, the thaw from low to full power. Dosages are mainly made by high performance liquid chromatography. Most of the 59 drugs are stable during and after treatment. Only 3 teams have tested the long-term stability after MFTT, the first for ganciclovir after 7 days, the second for ceftizoxime after 30 days and the third for 19 drugs after 11 to 70 days. This review can help CIVAS to take in charge the productions of ready-to-use injectable drugs. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Changes in food and nutrient intake of 6- to 17-year-old Germans between the 1980s and 2006.

PubMed

Stahl, Anna; Vohmann, Claudia; Richter, Almut; Heseker, Helmut; Mensink, Gert B M

2009-10-01

To compare the food consumption and nutrient intakes of German children and adolescents in the 1980s with present dietary habits. Two cross-sectional representative surveys, the German National Food Consumption Study (Nationale Verzehrsstudie, NVS) from 1985-8 and the nutrition module 'EsKiMo' of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) from 2006, were analysed for differences in food and nutrient intakes stratified by age and sex groups. Secondary analyses of data from representative observational studies. Children and adolescents aged 6-17 years living in Germany in the 1980s (n 2265) and in 2006 (n 2506). Food consumption was characterised by higher amounts of vegetables/pulses, fruits/nuts and beverages and less meat products/sausages, butter, fats/oils, potatoes/potato products and bread/pastries in 2006 than in 1985-8. The overall changes in food intake were reflected in improvements of macronutrient composition, increased water intake and lower energy density of the diet. Intake of most vitamins and minerals increased in relation to energy intake, but the nutrient density of the diet for vitamins B12 and D decreased. The most critical nutrients observed in NVS and EsKiMo were folate, vitamin D, vitamin A, vitamin E, Ca and Fe. In addition, dietary fibre intake was relatively low and fatty acid and carbohydrate compositions were not favourable. Further efforts will be necessary to improve dietary habits among children and adolescents.

[Bell's palsy].

PubMed

Prud'hon, S; Kubis, N

2018-03-30

Idiopathic peripheral facial palsy, also named Bell's palsy, is the most common cause of peripheral facial palsy in adults. Although it is considered as a benign condition, its social and psychological impact can be dramatic, especially in the case of incomplete recovery. The main pathophysiological hypothesis is the reactivation of HSV 1 virus in the geniculate ganglia, leading to nerve edema and its compression through the petrosal bone. Patients experience an acute (less than 24 hours) motor deficit involving ipsilateral muscles of the upper and lower face and reaching its peak within the first three days. Frequently, symptoms are preceded or accompanied by retro-auricular pain and/or ipsilateral face numbness. Diagnosis is usually clinical but one should look for negative signs to eliminate central facial palsy or peripheral facial palsy secondary to infectious, neoplastic or autoimmune diseases. About 75% of the patients will experience spontaneous full recovery, this rate can be improved with oral corticotherapy when introduced within the first 72 hours. To date, no benefit has been demonstrated by adding an antiviral treatment. Hemifacial spasms (involuntary muscles contractions of the hemiface) or syncinesia (involuntary muscles contractions elicited by voluntary ones, due to aberrant reinnervation) may complicate the disease's course. Electroneuromyography can be useful at different stages: it can first reveal the early conduction bloc, then estimate the axonal loss, then bring evidence of the reinnervation process and, lastly, help for the diagnosis of complications. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Problems encountered by hospital pharmacists with information systems: Analysis of exchanges within social networks].

PubMed

Charpiat, B; Mille, F; Fombeur, P; Machon, J; Zawadzki, E; Bobay-Madic, A

2018-05-21

The development of information systems in French hospitals is mandatory. The aim of this work was to analyze the content of exchanges carried out within social networks, dealing with problems encountered with hospital pharmacies information systems. Messages exchanged via the mailing list of the Association pour le Digital et l'Information en Pharmacie and abstracts of communications presented at hospital pharmacists trade union congresses were analyzed. Those referring to information systems used in hospital pharmacies were selected. From March 2015 to June 2016, 122 e-mails sent by 80 pharmacists concerned information systems. From 2002 to 2016, 45 abstracts dealt with this topic. Problems most often addressed in these 167 documents were "parameterization and/or functionalities" (n=116), interfaces and complexity of the hospital information systems (n=52), relationship with health information technologies vendors and poor reactivity (n=32), additional workload (n=32), ergonomics (n=30), insufficient user training (n=22). These problems are interdependent, lead to errors and in order to mitigate their consequences, they compel pharmacy professionals to divert a significant amount of working hours to the detriment of pharmaceutical care and dispensing and preparing drugs. Hospital pharmacists are faced with many problems of insecurity and inefficiency generated by information systems. Researches are warranted to determine their cost, specify their deleterious effects on care and identify the safest information systems. Copyright © 2018 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Préoccupations de carrière chez les médecins de travail des groupements de Médecine de travail en Tunisie

PubMed Central

Merchaoui, Irtyah; Chouchène, Asma; Bouanène, Ines; Chaari, Néila; Zrafi, Wassim; Henchi, Adnène; Akrout, Mohamed; Amri, Charfeddine

2017-01-01

Introduction L'insatisfaction de carrière des médecins de travail (MT) peut influencer leur performance et la qualité des prestations fournies. L'objectif de notre étude est d'évaluer la satisfaction au travail des MT du terrain de l'ensemble des Groupements de médecine de travail (GMT) de la Tunisie et préciser les facteurs déterminants. Méthodes Il s'agit d'une étude nationale transversale portant sur les MT de 22 GMT, basée sur le questionnaire, validé SAPHORA JOB. Résultats 58% des MT des GMT étaient insatisfaits de leur carrière. La satisfaction de carrière était statistiquement influencée par le nombre d'entreprises en charge (p=0,016), l'organisation du travail (p=0,010),le ressenti du métier (p=0,011),le salaire (p‹10-3) et l'information sur la réglementation en vigueur (p=0,047). Conclusion L'homogénéisation des grilles salariales et des échelons de carrière des MT des GMT basée sur une révision des textes législatifs est indiquée. L'amélioration de l'organisation et des conditions de travail peut permettre un épanouissement au travail et une amélioration des prestations. PMID:28819472

[Gut microbiota: Description, role and pathophysiologic implications].

PubMed

Landman, C; Quévrain, E

2016-06-01

The human gut contains 10(14) bacteria and many other micro-organisms such as Archaea, viruses and fungi. Studying the gut microbiota showed how this entity participates to gut physiology and beyond this to human health, as a real "hidden organ". In this review, we aimed to bring information about gut microbiota, its structure, its roles and its implication in human pathology. After bacterial colonization in infant, intestinal microbial composition is unique for each individual although more than 95% can be assigned to four major phyla. The use of culture independent methods and more recently the development of high throughput sequencing allowed to depict precisely gut microbiota structure and diversity as well as its alteration in diseases. Gut microbiota is implicated in the maturation of the host immune system and in many fundamental metabolic pathways including sugars and proteins fermentation and metabolism of bile acids and xenobiotics. Imbalance of gut microbial populations or dysbiosis has important functional consequences and is implicated in many digestive diseases (inflammatory bowel diseases, colorectal cancer, etc.) but also in obesity and autism. These observations have led to a surge of studies exploring therapeutics which aims to restore gut microbiota equilibrium such as probiotics or fecal microbiota transplantation. But recent research also investigates biological activity of microbial products which could lead to interesting therapeutics leads. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Pre-eclampsia prevention in 2018 in general population and in lupic women: At the dawn of a personalized medicine?

PubMed

de Moreuil, C; Fauchais, A-L; Merviel, P; Tremouilhac, C; Le Moigne, E; Pasquier, E; Pan-Petesch, B; Lacut, K

2018-06-19

Pre-eclampsia prevention represents a major public health issue, as this vasculo-placental disorder generates a great burden of foeto-maternal morbi-mortality. Aspirin has proved its efficacy in primary and secondary pre-eclampsia prevention, especially when it is given at 150mg per day bedtime before 15 weeks of gestation to high-risk women. In the English trial ASPRE, high-risk women were identified by an algorithm taking into account angiogenic biomarkers ascertained at the end of first trimester of pregnancy. This article focuses on physiopathological mechanisms and risk factors of pre-eclampsia and on the interest of early angiogenic biomarkers dosing during pregnancy, for the assessment of pre-eclampsia risk. Unlike Great Britain or Israel, cost-effectiveness of this algorithm in general population has not been assessed in France. Finally, systemic lupus erythematous is at high risk of vasculo-placental disorders. Although few studies of angiogenic biomarkers dosing during lupus pregnancies identified a correlation between high sFlt1 levels at the end of first trimester and subsequent onset of severe vasculo-placental disorders, with a very good negative predictive value of sFtl1. Angiogenic biomarkers ascertainment for screening of vasculo-placental disorders in pregnant women with systemic lupus erythematous could allow targeting at best women needing an aspirin treatment and a closer monitoring. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Nutrient profiling can help identify foods of good nutritional quality for their price: a validation study with linear programming.

PubMed

Maillot, Matthieu; Ferguson, Elaine L; Drewnowski, Adam; Darmon, Nicole

2008-06-01

Nutrient profiling ranks foods based on their nutrient content. They may help identify foods with a good nutritional quality for their price. This hypothesis was tested using diet modeling with linear programming. Analyses were undertaken using food intake data from the nationally representative French INCA (enquête Individuelle et Nationale sur les Consommations Alimentaires) survey and its associated food composition and price database. For each food, a nutrient profile score was defined as the ratio between the previously published nutrient density score (NDS) and the limited nutrient score (LIM); a nutritional quality for price indicator was developed and calculated from the relationship between its NDS:LIM and energy cost (in euro/100 kcal). We developed linear programming models to design diets that fulfilled increasing levels of nutritional constraints at a minimal cost. The median NDS:LIM values of foods selected in modeled diets increased as the levels of nutritional constraints increased (P = 0.005). In addition, the proportion of foods with a good nutritional quality for price indicator was higher (P < 0.0001) among foods selected (81%) than among foods not selected (39%) in modeled diets. This agreement between the linear programming and the nutrient profiling approaches indicates that nutrient profiling can help identify foods of good nutritional quality for their price. Linear programming is a useful tool for testing nutrient profiling systems and validating the concept of nutrient profiling.

[Anti-pneumococcal vaccine coverage for hospitalized risk patients: Assessment and suggestions for improvements].

PubMed

Richard, C; Le Garlantezec, P; Lamand, V; Rasamijao, V; Rapp, C

2016-05-01

Streptococcus pneumoniae can cause invasive infections. Incidence and severity are linked to patients' risk factors. Due to the resistance to leading antibiotics, the anti-pneumococcal vaccination has become a major public health issue. The purpose of this survey was to evaluate the anti-pneumococcal vaccine coverage in a population of adults with risk factors. This was a prospective study that included patients with at least one recommendation for pneumococcal vaccination as indicated by the Weekly Epidemiological Bulletin (BEH), to which three further US recommendations were added (diabetes, obesity and age>65years). One hundred and thirty-four patients with an average age of 70 years were included. The physician could only confirm 68 % of the patients' vaccination status. Vaccination coverage as recommended by the BEH board was 30 % (n=54). All HIV patients were vaccinated (n=2) and the vaccination coverage was 75 % (n=8) for patients treated for autoimmune diseases and only 10 % (n=20) for patients treated with chemotherapy. Patients with no vaccination didn't know the existence of the vaccine or didn't know that vaccination was recommended to them. This study has highlighted a deficit in pneumococcal vaccination coverage and a high level of ignorance of the existence of recommended vaccination. In addition to awareness campaign for patients and caregiver training, the expansion of the vaccine e-book utilization could improve the vaccination status. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Thrombotic thrombocytopenia purpura in Martinique: Retrospective study between 2008 and 2015].

PubMed

Patient, M; Fuseau, P; Deligny, C

2017-08-01

Some studies suggest that thrombotic thrombocytopenic purpura (TTP) occurs more often in African Americans. However there is low evidence for this in the literature. The aim of our study was to describe the clinical and biological characteristics of TTP in the Afro-Caribbean population of Martinique. We retrospectively analysed all patients with TTP diagnosed at the Fort-de-France hospital between 2008, January 1st and 2015, December 31st. Diagnosis was confirmed if ADAMTS-13 activity was<10 %. Ten patients were included, corresponding to an average annual incidence of 3.2 cases/year/million individuals. None of the patient presented with the association of the five characteristic features of TTP. Microangiopathic haemolytic anaemia and severe peripheral thrombocytopenia (median: 13G/L) was the main presentation leading to diagnosis. There was no kidney involvement in 90 % of all patients, but severe neurological manifestations occurred in 70 %. Classical management including corticosteroids and plasma exchanges allowed clinical remission in 6 out of the 10 cases. If necessary, rituximab or cyclophosphamide was used. The overall survival rate was 90 %. In Martinique, the incidence of TTP is twice that reported in similar studies in France. Clinical manifestations seem to differ by more common and more severe neurological involvement. Mortality is low, in part, due to optimal care. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Study of parenteral iron use in a health facility and its impact in terms of hospital economics].

PubMed

Vonesch, M-A; Grangier, G; Girard, P; Dussart, C

2016-07-01

Administration of parenteral iron is a mainstay of iron deficiency treatment. Evaluation and control of this element is an issue for healthcare facilities. Study of parenteral iron use is thus to be evaluated in its impact in terms of hospital economics. Parenteral iron administrations that took place on 2014 in our healthcare facility were retrospectively identified by pharmacists. Following data were extracted from Pharma™ and Crossway™ softwares: indication, diagnostic coding and total dose of iron received. They were then compared to the summary of product characteristics. Of 198 analyzed prescriptions, iron deficiency was known or suspected for 97% of patients. However, the total dose of iron administered was not in compliance for three quarters of prescriptions. Sixty-eight percent of patients appear under-dosed. Administration's traceability was found for two-thirds. Eighty-five hospital discharges did not have the right coding and 34 stays were charged like an external act instead sessions. Financial loss for the hospital is estimated at 49,300 euros. As part of improving practice, close pharmaceutical monitoring of parenteral iron prescribed dosing regimen is essential. Effective communication with the medical information department and regular awareness raising of prescribers should also allow to give more value to this act. Hospital economics is a real tool to aid decision-making. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Changes in olfaction during ageing and in certain neurodegenerative diseases: up-to-date].

PubMed

Bianchi, A-J; Guépet-Sordet, H; Manckoundia, P

2015-01-01

Olfaction is a complex sensory system, and increasing interest is being shown in the link between olfaction and cognition, notably in the elderly. In this literature review, we revisit the specific neurophysiological features of the olfactory system and odorants that lead to a durable olfactory memory and an emotional memory, for which the implicit component produces subconscious olfactory conditioning. Olfaction is known to affect cognitive abilities and mood. We also consider the impairment of olfactory function due to ageing and to neurodegenerative diseases, in particular Alzheimer's disease and Parkinson's disease, through anatomopathological changes in the peripheral and central olfactory structures. The high frequency of these olfactory disorders as well as their early occurrence in Alzheimer disease and Parkinson disease are in favour of their clinical detection in subjects suffering from these two neurodegenerative diseases. Finally, we analyse the impact of olfactory stimulation on cognitive performance and attention. Current observational data from studies in elderly patients with Alzheimer-type dementia are limited to multiple sensory stimulation methods, such as the Snoezelen method, and aromatherapy. These therapies have shown benefits for dementia-related mood and behaviour disorders in the short term, with few side effects. Since olfactory chemosensory stimulation may be beneficial, it may be proposed in patients with dementia, especially Alzheimer-type dementia, as a complementary or even alternative therapy to existing medical strategies. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Radioactive waste management in France and international cooperation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marque, Y.

1991-01-01

Long-term industrial management of radioactive waste in France is carried out by the Agence Nationale pour la gestion des Dechets Radioactifs. (ANDRA), which is a public body responsible mainly for siting, design, construction, and operation of the disposal facilities for every kind of radioactive waste produced in the country. Furthermore, ANDRA has to define and control the required quality of waste packages delivered for disposal. As far as disposal is concerned, it is customary in France to classify waste in two main categories. The first category includes all the so-called short-lived low-level waste (LLW) containing mainly radioactive substances have

Comparison of the Explantation Rate of Poly Implant Prothèse, Allergan, and Pérouse Silicone Breast Implants within the First Four Years after Reconstructive Surgery before the Poly Implant Prothèse Alert by the French Regulatory Authority.

PubMed

Leduey, Alexandre; Mazouni, Chafika; Leymarie, Nicolas; Alkhashnam, Heba; Sarfati, Benjamin; Garbay, Jean-Rémi; Gaudin, Amélie; Kolb, Frédéric; Rimareix, Françoise

2015-01-01

Background. In March 2010, ANSM (Agence Nationale de Sécurité du Medicament), the French Medical Regulatory Authority, withdrew Poly Implant Prothèse (PIP) breast implants from the market due to the use of non-medical-grade silicone gel. The aim of this study was to compare the removal rate (and reasons thereof) of breast implants produced by different manufacturers before the ANSM alert. Materials and Methods. From October 2006 to January 2010, 652 women received 944 implants after breast cancer surgery at the Gustave Roussy Comprehensive Cancer Center, Paris (France). The complications and removal rates of the different implant brands used (PIP, Allergan, and Pérouse) were evaluated and compared. Results. PIP implants represented 50.6% of the used implants, Allergan 33.4%, and Pérouse 16%. The main reasons for implant removal were patient dissatisfaction due to aesthetic problems (43.2%), infection (22.2%), and capsular contracture (13.6%). Two years after implantation, 82% of Pérouse implants, 79% of PIP, and 79% of Allergan were still in situ. There was no difference in removal rate among implant brands. Conclusion. Before the ANSM alert concerning the higher rupture rate of PIP breast implants, our implant removal rate did not predict PIP implant failure related to the use of nonapproved silicone gel.

Comparison of the Explantation Rate of Poly Implant Prothèse, Allergan, and Pérouse Silicone Breast Implants within the First Four Years after Reconstructive Surgery before the Poly Implant Prothèse Alert by the French Regulatory Authority

PubMed Central

Leduey, Alexandre; Mazouni, Chafika; Leymarie, Nicolas; Alkhashnam, Heba; Sarfati, Benjamin; Garbay, Jean-Rémi; Gaudin, Amélie; Kolb, Frédéric; Rimareix, Françoise

2015-01-01

Background. In March 2010, ANSM (Agence Nationale de Sécurité du Medicament), the French Medical Regulatory Authority, withdrew Poly Implant Prothèse (PIP) breast implants from the market due to the use of non-medical-grade silicone gel. The aim of this study was to compare the removal rate (and reasons thereof) of breast implants produced by different manufacturers before the ANSM alert. Materials and Methods. From October 2006 to January 2010, 652 women received 944 implants after breast cancer surgery at the Gustave Roussy Comprehensive Cancer Center, Paris (France). The complications and removal rates of the different implant brands used (PIP, Allergan, and Pérouse) were evaluated and compared. Results. PIP implants represented 50.6% of the used implants, Allergan 33.4%, and Pérouse 16%. The main reasons for implant removal were patient dissatisfaction due to aesthetic problems (43.2%), infection (22.2%), and capsular contracture (13.6%). Two years after implantation, 82% of Pérouse implants, 79% of PIP, and 79% of Allergan were still in situ. There was no difference in removal rate among implant brands. Conclusion. Before the ANSM alert concerning the higher rupture rate of PIP breast implants, our implant removal rate did not predict PIP implant failure related to the use of nonapproved silicone gel. PMID:26543648

[Drug-food interactions in internal medicine: What physicians should know?].

PubMed

Mouly, S; Morgand, M; Lopes, A; Lloret-Linares, C; Bergmann, J-F

2015-08-01

Orally administered medications may interact with various fruits, vegetables, herbal medicines, functional foods or dietary supplements. Drug-food interactions, which are mostly unknown from prescribers, including internists, may be responsible for changes in drug plasma concentrations, which may decrease efficacy or led to sometimes life-threatening toxicity. Aging, concomitant medications, transplant recipients, patients with cancer, malnutrition, HIV infection and those receiving enteral or parenteral feeding are at increased risk of drug-food interactions. This review focused on the most clinically relevant drug-food interactions, including those with grapefruit juice, Saint-John's Wort, enteral or parenteral nutrition, their respective consequences in the clinical setting in order to provide thoughtful information for internists in their routine clinical practice. Specific clinical settings are also detailed, such as the Ramadan or multiple medications especially in elderly patients. Drug-food interactions are also presented with respect to the main therapeutic families, including the non-steroidal anti-inflammatory drugs, analgesics, cardiovascular medications, warfarin as well as new oral anticoagulants, anticancer drugs and immunosuppressant medications. Considerable effort has been achieved to a better understanding of food-drug interactions and increase clinicians' ability to anticipate their occurrence and consequences in clinical practice. Describing the frequency of relevant food-drug interactions in internal medicine is paramount in order to optimize patient care and drug dosing on an individual basis as well as to increase patients and doctors information. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Clinical pharmacist influence at hospital to prevent overdosed prescription of acetaminophen].

PubMed

Viguier, F; Roessle, C; Zerhouni, L; Rouleau, A; Benmelouka, C; Chevallier, A; Chast, F; Conort, O

2016-11-01

The recommended daily dose of acetaminophen is limited to 60mg/kg/day with a maximum of 3g daily dose in adults weighing less than 50kg or in patients undergoing certain risk factors. This study aimed at assessing the fulfillment of those recommendations and the possible impact on the liver dysfunction at supra-therapeutic doses of acetaminophen. This study was performed one day in 9 services. Patients characteristics, acetaminophen dose, daily dose administered, physiopathological aspects, markers of liver damage were collected. Among 542 prescriptions analyzed, 343 of them contained acetaminophen. The median age of patients studied was 81 years and one third weighed less than 50kg. The main risk factor of supra-therapeutic prescriptions was the lack of dose acetaminophen based on weight with 14% patients concerned and this risk raised at 17% when the pathophysiological conditions were included. The presence of pharmacists in medicals departments was more effective than the use of informatics programs limiting the dose systematically to 3g/day, or a distant pharmaceutical validation from care services to reduce the risk of acetaminophen overdose. According to the statement of administrations, only 4 of 49 patients received doses above 60mg/kg/day with a low impact on liver function tests. The continuous presence in pharmaceutical care services was the most effective measure to ensure effective implementation of acetaminophen recommendations. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Pharmacist's interview with type 2 diabetes: Development of a follow-up form].

PubMed

Garcia Santos, P; Bernard, L; Bedhomme, S; Blum, S; Gravelin, M; Leonce, M F; McLeod, M L; Roche, B; Roche, M C; Van Lander, A; Sautou, V; Vennat, B

2017-09-01

Type 2 diabetes is a major public health concern because of its prevalence, the severity of complications and the financial implications. Compliance and patient's autonomy in medications intake play key roles in the success of treatment. Pharmacists' interviews ensure an optimized and individual follow-up. Type 2 diabetes is not one of the targeted diseases to perform pharmacists' interviews on under Health Insurance. We thus judged useful to contribute to their development. We applied a cross-disciplinary methodological process in order to define the specifications of the follow-up form useful to conduct the pharmacist's interview 1 by focusing on the identification of a non-compliance and its origins. A feasibility study was carried out in order to check its workability to the pharmacy practice. The follow-up form, associated with a pharmacist practical guide, includes 3 parts: (1) General informations, (2) Survey establishing patient's knowledge, (3) Summary including a level of knowledge assessment grid. Outcomes provide a long but appropriate-felt duration, few difficulties to conduct the interview and a proven usefulness in 90% of all cases that make the follow-up form suitable to the pharmacy practice. This tool could serve as a model for the pharmacist to conduct his future interviews for the type 2 diabetes patients, thus improving patient care, together with other health professionals. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Circular flow patterns induced by ciliary activity in reconstituted human bronchial epithelium

NASA Astrophysics Data System (ADS)

Viallat, Annie; Khelloufi, Kamel; Gras, Delphine; Chanez, Pascal; Aix Marseille Univ., CNRS, CINaM, Marseille, France Team; Aix Marseille Univ., CNRS, Inserm, LAI, Marseille, France Team

2016-11-01

Mucociliary clearance is the transport at the surface of airways of a complex fluid layer, the mucus, moved by the beats of microscopic cilia present on epithelial ciliated cells. We explored the coupling between the spatial organisation and the activity of cilia and the transport of surface fluids on reconstituted cultures of human bronchial epithelium at air-liquid interface, obtained by human biopsies. We reveal the existence of stable local circular surface flow patterns of mucus or Newtonian fluid at the epithelium surface. We find a power law over more than 3 orders of magnitude showing that the average ciliated cell density controls the size of these flow patterns, and, therefore the distance over which mucus can be transported. We show that these circular flow patterns result from the radial linear increase of the local propelling forces (due to ciliary beats) on each flow domain. This linear increase of local forces is induced by a fine self-regulation of both cilia density and orientation of ciliary beats. Local flow domains grow and merge during ciliogenesis to provide macroscopic mucus transport. This is possible only when the viscoelastic mucus continuously exerts a shear stress on beating cilia, revealing a mechanosensitive function of cilia. M. K. Khelloufi thanks the society MedBioMed for financial support. This work was supported by the ANR MUCOCIL project, Grant ANR-13-BSV5-0015 of the French Agence Nationale de la Recherche.

Nematic fluctuations and resonance in iron-based superconductors

NASA Astrophysics Data System (ADS)

Gallais, Yann

The spontaneous appearance of nematicity, a state of matter that breaks rotation but not translation symmetry, is ubiquitous in many iron based superconductors (Fe SC), and has relevance for the cuprates as well. Here I will review recent electronic Raman scattering experiments which report the presence of critical nematic fluctuations in the charge channel in the tetragonal phase of several Fe SC systems. In electron doped Co-BaFe2As2 (Co-Ba122), these fluctuations extend over most of the superconducting dome. Their associated nematic susceptibility shows Curie-Weiss behavior, and its doping dependence suggests the presence of a nematic quantum critical point near optimal TC Similar nematic fluctuations are also observed in FeSe despite the absence of magnetic order, raising the question of the link between nematicity and magnetism in Fe SC. In FeSe I will further contrast the evolution of nematic fluctuations under isoelectronic S substitution and hydrostatic pressures up to 8 GPa, with only the former showing evidence for a nematic quantum critical point. In the superconducting state of Co-Ba122, I will show that a resonance emerges in the Raman spectra near the nematic quantum critical point. This nematic resonance is a clear fingerprint of the coupling between nematic fluctuations and Bogoliubov quasiparticles, and can be thought as the nematic counterpart of the spin resonance observed in neutron scattering experiments. Support from Agence Nationale de la Recherche via ANR Grant ''Pnictides'' is acknowledged.

Redistribution of annexin in gravistimulated pea plumules

NASA Technical Reports Server (NTRS)

Clark, G. B.; Rafati, D. S.; Bolton, R. J.; Dauwalder, M.; Roux, S. J.

2000-01-01

We used immunocytochemistry to investigate the effects of gravistimulation on annexin localization in etiolated pea plumule shoots. In longitudinal sections, an asymmetric annexin immunostaining pattern was observed in a defined group of cells located just basipetal to apical meristems at the main shoot apex and at all of the axillary buds, an area classically referred to as the leaf gap. The pattern was observed using both protein-A-purified anti-annexin and affinity-purified anti-annexin antibodies for the immunostaining. A subset of the cells with the annexin staining also showed an unusually high level of periodic acid Schiff (PAS) staining in their cell walls. Prior to gravistimulation, the highest concentration of annexin was oriented toward the direction of gravity along the apical end of these immunostained cells. In contrast, both at 15 and 30 min after gravistimulation, the annexin immunostain became more evenly distributed all around the cell and more distinctly cell peripheral. The asymmetry along the lower wall of these cells was no longer evident. In accord with current models of annexin action, we interpret the results to indicate that annexin-mediated secretion in the leaf gap area is preferentially toward the apical meristem prior to gravistimulation, and that gravistimulation results in a redirection of this secretion. These data are to our knowledge the first to show a correlation between the vector of gravity and the distribution of annexins in the cells of flowering plants. c 2000 Editions scientifiques et medicales Elsevier SAS.

International Congress on Transposable Elements (ICTE) 2012 in Saint Malo and the sea of TE stories.

PubMed

Ainouche, Abdelkader; Bétermier, Mireille; Chandler, Mick; Cordaux, Richard; Cristofari, Gaël; Deragon, Jean-Marc; Lesage, Pascale; Panaud, Olivier; Quesneville, Hadi; Vaury, Chantal; Vieira, Cristina; Vitte, Clémentine

2012-10-30

An international conference on Transposable Elements (TEs) was held 21-24 April 2012 in Saint Malo, France. Organized by the French Transposition Community (GDR Elements Génétiques Mobiles et Génomes, CNRS) and the French Society of Genetics (SFG), the conference's goal was to bring together researchers from around the world who study transposition in diverse organisms using multiple experimental approaches. The meeting drew more than 217 attendees and most contributed through poster presentations (117), invited talks and short talks selected from poster abstracts (48 in total). The talks were organized into four scientific sessions, focused on: impact of TEs on genomes, control of transposition, evolution of TEs and mechanisms of transposition. Here, we present highlights from the talks given during the platform sessions. The conference was sponsored by Alliance pour les sciences de la vie et de la santé (Aviesan), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut de recherche pour le développement (IRD), Institut national de la recherche agronomique (INRA), Université de Perpignan, Université de Rennes 1, Région Bretagne and Mobile DNA. CHAIR OF THE ORGANIZATION COMMITTEE: Jean-Marc Deragon ORGANIZERS: Abdelkader Ainouche, Mireille Bétermier, Mick Chandler, Richard Cordaux, Gaël Cristofari, Jean-Marc Deragon, Pascale Lesage, Didier Mazel, Olivier Panaud, Hadi Quesneville, Chantal Vaury, Cristina Vieira and Clémentine Vitte.

Entrevue avec le Dr Charley Zeanah

PubMed Central

2013-01-01

Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

Etude de faisabilite d'un systeme eolien diesel avec stockage d'air comprime

NASA Astrophysics Data System (ADS)

Benchaabane, Youssef

Le Systeme Hybride Eolien-Diesel avec Stockage d'Air Comprime (SHEDAC) utilise l'hybridation pneumatique pour remplacer la consommation des combustibles fossiles par de l'energie renouvelable, plus particulierement de l'energie eolienne. Le surplus de l'energie eolienne est utilise pour comprimer et stocker de l'air qui est utilise ensuite pour suralimenter le moteur diesel. Le memoire de maitrise est constitue de deux articles scientifiques. Le premier article presente le developpement d'un logiciel dedie a l'etude de faisabilite d'un systeme eolien-diesel avec stockage d'air comprime. Cette etude est basee sur l'analyse des couts et des revenus, des couts des equipements (eolienne, moteur diesel, systeme de stockage d'air). Elle est completee par une analyse de sensibilite aux differents parametres, une analyse des risques et des emissions des gaz a effet de serre (GES). Le deuxieme article est une application de ce logiciel pour l'installation d'un systeme SHEDAC au camp minier Esker au Quebec en remplacement des sources actuelles de production d'energie. L'utilisation du stockage d'air comprime a l'aide d'un systeme SHEDAC est le plus rentable par rapport a l'utilisation de l'energie eolienne seule ou d'une centrale thermique au diesel seule ou des deux combinees. Avec une valeur actuelle nette et un taux de rendement interne plus eleves, cette solution permet d'obtenir le plus bas cout de l'energie pour cette region eloignee. None None None

Calculations of dose distributions using a neural network model

NASA Astrophysics Data System (ADS)

Mathieu, R.; Martin, E.; Gschwind, R.; Makovicka, L.; Contassot-Vivier, S.; Bahi, J.

2005-03-01

The main goal of external beam radiotherapy is the treatment of tumours, while sparing, as much as possible, surrounding healthy tissues. In order to master and optimize the dose distribution within the patient, dosimetric planning has to be carried out. Thus, for determining the most accurate dose distribution during treatment planning, a compromise must be found between the precision and the speed of calculation. Current techniques, using analytic methods, models and databases, are rapid but lack precision. Enhanced precision can be achieved by using calculation codes based, for example, on Monte Carlo methods. However, in spite of all efforts to optimize speed (methods and computer improvements), Monte Carlo based methods remain painfully slow. A newer way to handle all of these problems is to use a new approach in dosimetric calculation by employing neural networks. Neural networks (Wu and Zhu 2000 Phys. Med. Biol. 45 913-22) provide the advantages of those various approaches while avoiding their main inconveniences, i.e., time-consumption calculations. This permits us to obtain quick and accurate results during clinical treatment planning. Currently, results obtained for a single depth-dose calculation using a Monte Carlo based code (such as BEAM (Rogers et al 2003 NRCC Report PIRS-0509(A) rev G)) require hours of computing. By contrast, the practical use of neural networks (Mathieu et al 2003 Proceedings Journées Scientifiques Francophones, SFRP) provides almost instant results and quite low errors (less than 2%) for a two-dimensional dosimetric map.

Calculations of dose distributions using a neural network model.

PubMed

Mathieu, R; Martin, E; Gschwind, R; Makovicka, L; Contassot-Vivier, S; Bahi, J

2005-03-07

The main goal of external beam radiotherapy is the treatment of tumours, while sparing, as much as possible, surrounding healthy tissues. In order to master and optimize the dose distribution within the patient, dosimetric planning has to be carried out. Thus, for determining the most accurate dose distribution during treatment planning, a compromise must be found between the precision and the speed of calculation. Current techniques, using analytic methods, models and databases, are rapid but lack precision. Enhanced precision can be achieved by using calculation codes based, for example, on Monte Carlo methods. However, in spite of all efforts to optimize speed (methods and computer improvements), Monte Carlo based methods remain painfully slow. A newer way to handle all of these problems is to use a new approach in dosimetric calculation by employing neural networks. Neural networks (Wu and Zhu 2000 Phys. Med. Biol. 45 913-22) provide the advantages of those various approaches while avoiding their main inconveniences, i.e., time-consumption calculations. This permits us to obtain quick and accurate results during clinical treatment planning. Currently, results obtained for a single depth-dose calculation using a Monte Carlo based code (such as BEAM (Rogers et al 2003 NRCC Report PIRS-0509(A) rev G)) require hours of computing. By contrast, the practical use of neural networks (Mathieu et al 2003 Proceedings Journees Scientifiques Francophones, SFRP) provides almost instant results and quite low errors (less than 2%) for a two-dimensional dosimetric map.

Avant Propos

NASA Astrophysics Data System (ADS)

Cornet, Alain; Broll, Norbert; Denier, Philippe

2002-07-01

Le quatrième colloque Rayons X et Matière (RX 2001) s'est tenu à Strasbourg du 4 au 7 décembre 2001. Comme lors des colloques précédents (1995, 1997 et 1999) nous avons pu réunir de nombreux chercheurs, industriels et constructeurs concernés par la caractérisation des matériaux. Cette manifestation qui se déroule tous les deux ans a pour objectifs de rendre compte périodiquement des avancées faites dans le domaine des techniques X et plus particulièrement de l'ingénierie des surfaces. Cette année nous avons ajouté deux nouveaux thèmes : étude des nanomatériaux et techniques des microfaisceaux. André GUINIER était avec nous lors du premier colloque (colloque 1995, consacré à la commémoration du centenaire de la découverte des rayons X). Nous sommes attristés par son décès et nous lui dédions le Colloque RX 2001. Les premiers articles de cet ouvrage rappellent sa vie de scientifique et ses principaux travaux. En même temps que nous écrivons ces quelques lignes, nous nous préparons à lancer le colloque RX 2003. Ces colloques ont lieu grâce à la participation constante des chercheurs et l'engagement des constructeurs et distributeurs de matériels ; nous les en remercions vivement et nous leur donnons rendez-vous à Strasbourg, en décembre 2003.

[How to promote the respect of good infusion practices by meeting health care professionals?].

PubMed

Le Reste, C; Fiedler, A; Dubois, S; Dewailly, A; Le Du, I; Cogulet, V

2016-05-01

Health care professionals often forget that there are risks associated with infusion therapy even if it is a common care. In order to assess this practice and to draw potential improvement actions, an audit of local gravity-flow intravenous infusion practices was conducted. The audit, based on a grid including 66 items from the medical prescription to the end of the infusion therapy administration, was conducted in the 6 units which use the most gravity-flow intravenous infusion devices. A multidisciplinary working group was created to decide and organize priority corrective measures in order to improve infusion practices and quality of healthcare. The audit enabled to observe 90hours of nurse's practices (96 infusions) and highlighted heterogeneity in infusion, in some cases inappropriate infusion practices and misuse of infusion devices. We found 4 main issues: labelling infusion therapy, training of health care professionals on good practices, support the purchase of infusion pumps and standardize perfusion line. An interactive educational program for nurses (workshops) was organized to enhance the respect of good practices: infusion identification at any time, respect of hygiene rules, flow rate regulation by counting drops, appropriate use of pumps and flow rate regulators. The audit drew up work priorities. The workshops made easier exchanges between professionals and had a warm welcome that's why it is essential to carry on such training. This collaborative approach between pharmacists, nurses, hygienists and biomedical technicians contribute to drug management improvement and promote optimal patient care. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Development and efficacy assessments of tea seed oil makeup remover.

PubMed

Parnsamut, N; Kanlayavattanakul, M; Lourith, N

2017-05-01

The efficacy of tea seed oil to clean foundation and eyeliner was evaluated. The safe and efficient tea seed oil makeup remover was developed. In vitro cleansing efficacy of makeup remover was UV-spectrophotometric validated. The stability evaluation by means of accelerated stability test was conducted. In vitro and in vivo cleansing efficacy of the removers was conducted in a comparison with benchmark majorly containing olive oil. Tea seed oil cleaned 90.64±4.56% of foundation and 87.62±8.35% of eyeliner. The stable with most appropriate textures base was incorporated with tea seed oil. Three tea seed oil removers (50, 55 and 60%) were stabled. The 60% tea seed oil remover significantly removed foundation better than others (94.48±3.37%; P<0.001) and the benchmark (92.32±1.33%), but insignificant removed eyeliner (87.50±5.15%; P=0.059). Tea seed oil remover caused none of skin irritation as examined in 20 human volunteers. A single-blind, randomized control exhibited that the tea seed oil remover gained a better preference over the benchmark (75.42±8.10 and 70.00±7.78%; P=0.974). The safe and efficient tea seed oil makeup removers had been developed. The consumers' choices towards the makeup remover containing the bio-oils are widen. In vitro cleansing efficacy during the course of makeup remover development using UV-spectrophotometric method feasible for pharmaceutic industries is encouraged. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Computerized ranking test in three French universities: Staff experience and students' feedback].

PubMed

Roux, D; Meyer, G; Cymbalista, F; Bouaziz, J-D; Falgarone, G; Tesniere, A; Gervais, J; Cariou, A; Peffault de Latour, R; Marat, M; Moenaert, E; Guebli, T; Rodriguez, O; Lefort, A; Dreyfuss, D; Hajage, D; Ricard, J-D

2016-03-01

The year 2016 will be pivotal for the evaluation of French medical students with the introduction of the first computerized National Ranking Test (ECNi). The SIDES, online electronic system for medical student evaluation, was created for this purpose. All the universities have already organized faculty exams but few a joint computerized ranking test at several universities simultaneously. We report our experience on the organization of a mock ECNi by universities Paris Descartes, Paris Diderot and Paris 13. Docimological, administrative and technical working groups were created to organize this ECNi. Students in their fifth year of medical studies, who will be the first students to sit for the official ECNi in 2016, were invited to attend this mock exam that represented more than 50% of what will be proposed in 2016. A final electronic questionnaire allowed a docimological and organizational evaluation by students. An analysis of ratings and rankings and their distribution on a 1000-point scale were performed. Sixty-four percent of enrolled students (i.e., 654) attended the three half-day exams. No difference in total score and ranking between the three universities was observed. Students' feedback was extremely positive. Normalized over 1000 points, 99% of students were scored on 300 points only. Progressive clinical cases were the most discriminating test. The organization of a mock ECNi involving multiple universities was a docimological and technical success but required an important administrative, technical and teaching investment. Copyright © 2016 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Description and analysis of hospital pharmacies in Madagascar.

PubMed

Ratsimbazafimahefa, H R; Sadeghipour, F; Trouiller, P; Pannatier, A; Allenet, B

2018-05-01

Madagascar's health care system has operated without formal hospital pharmacies for more than two decades. The gradual integration of pharmacists in public hospitals since 2012 will allow the structuring of this field. This study was conducted to characterize the current situation regarding all aspects relating to the general functioning of hospital pharmacies and the services provided. This qualitative research used semi-structured interviews. Interviewees' perceptions about the general organization and functioning of hospital pharmacies and details on services provided were collected. The 16 interviewees were Ministry of Health staff members involved in hospital pharmacy, hospital directors, medical staff members and hospital pharmacy managers. Interviews were recorded, translated into French if conducted in Malagasy, and fully transcribed. Verbatim transcripts were coded according to the themes of hospital pharmacy and topical content analysis was performed. The principal issue perceived by interviewees was the heterogeneity of the system in terms of technical and financing management, with a main impact on the restocking of pharmaceutical products. The drug supply chain is not under control: no internal procedure has been established for the selection of pharmaceutical products, the quantification of needs is complex, stock management is difficult to supervise, a standard prescription protocol is lacking, dispensing is performed by unqualified staff, no pharmaceutical preparation is manufactured in the hospitals and administration occurs without pharmaceutical support. Progressive structuring of efficient hospital pharmacy services using the Basel statements for the future of hospital pharmacy is urgently needed to improve health care in Madagascar. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Immunoglobulin G particles manufacturing by spray drying process for pressurised metered dose inhaler formulations.

PubMed

Carli, V; Menu-Bouaouiche, L; Cardinael, P; Benissan, L; Coquerel, G

2018-07-01

The objective of this work is to show the feasibility of manufacturing from a spray drying process particles containing immunoglobulin G capable of being administered by inhalation via a pressurized metered dose inhaler. Spray drying were made from aqueous solutions containing IgG and two types of excipients, mannitol and trehalose, with two ratios: 25% w/w and 75%w/w. The physicochemical and aerodynamic properties of the powders obtained were characterized just after manufacturing and after 1 month of storage at 40°C/75% RH according to criteria defined as needed to satisfy an inhaled formulation with a pressurized metered dose inhaler. Maintain of the biological activity and the structure of IgG after atomization was also tested by slot blot and circular dichroism. All spray-dried powders presented a median diameter lower than 5μm. The powders atomized with trehalose showed a solid state more stable than those atomized with mannitol. All atomized powders were in the form of wrinkled particles regardless the nature and the ratios of excipients. The results showed that the aerosolisation properties were compliant with the target, independently of the excipient used at a ratio of 25% w/w IgG-excipient. Moreover, the addition of excipient during the atomization process the denaturation of IgG was limited. This study showed that the use of trehalose as excipient could satisfy the requirements of an inhaled formulation with a pressurized metered dose inhaler. Copyright © 2018 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Deep dermatophytosis and inherited CARD9 deficiency.

PubMed

Lanternier, Fanny; Pathan, Saad; Vincent, Quentin B; Liu, Luyan; Cypowyj, Sophie; Prando, Carolina; Migaud, Mélanie; Taibi, Lynda; Ammar-Khodja, Aomar; Stambouli, Omar Boudghene; Guellil, Boumediene; Jacobs, Frederique; Goffard, Jean-Christophe; Schepers, Kinda; Del Marmol, Véronique; Boussofara, Lobna; Denguezli, Mohamed; Larif, Molka; Bachelez, Hervé; Michel, Laurence; Lefranc, Gérard; Hay, Rod; Jouvion, Gregory; Chretien, Fabrice; Fraitag, Sylvie; Bougnoux, Marie-Elisabeth; Boudia, Merad; Abel, Laurent; Lortholary, Olivier; Casanova, Jean-Laurent; Picard, Capucine; Grimbacher, Bodo; Puel, Anne

2013-10-31

Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause. We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in an Iranian family with invasive fungal infections, we also sequenced CARD9 in the patients. Four patients died, at 28, 29, 37, and 39 years of age, with clinically active deep dermatophytosis. No other severe infections, fungal or otherwise, were reported in the surviving patients, who ranged in age from 37 to 75 years. The 15 Algerian and Tunisian patients, from seven unrelated families, had a homozygous Q289X CARD9 allele, due to a founder effect. The 2 Moroccan siblings were homozygous for the R101C CARD9 allele. Both alleles are rare deleterious variants. The familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance. All the patients with deep dermatophytosis had autosomal recessive CARD9 deficiency. Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency. (Funded by Agence Nationale pour la Recherche and others.).

Deep Dermatophytosis and Inherited CARD9 Deficiency

PubMed Central

Vincent, Quentin B.; Liu, Luyan; Cypowyj, Sophie; Prando, Carolina; Migaud, Mélanie; Taibi, Lynda; Ammar-Khodja, Aomar; Stambouli, Omar Boudghene; Guellil, Boumediene; Jacobs, Frederique; Goffard, Jean-Christophe; Schepers, Kinda; del Marmol, Véronique; Boussofara, Lobna; Denguezli, Mohamed; Larif, Molka; Bachelez, Hervé; Michel, Laurence; Lefranc, Gérard; Hay, Rod; Jouvion, Gregory; Chretien, Fabrice; Fraitag, Sylvie; Bougnoux, Marie-Elisabeth; Boudia, Merad

2014-01-01

BACKGROUND Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause. METHODS We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain–containing protein 9) deficiency has been reported in an Iranian family with invasive fungal infections, we also sequenced CARD9 in the patients. RESULTS Four patients died, at 28, 29, 37, and 39 years of age, with clinically active deep dermatophytosis. No other severe infections, fungal or otherwise, were reported in the surviving patients, who ranged in age from 37 to 75 years. The 15 Algerian and Tunisian patients, from seven unrelated families, had a homozygous Q289X CARD9 allele, due to a founder effect. The 2 Moroccan siblings were homozygous for the R101C CARD9 allele. Both alleles are rare deleterious variants. The familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance. CONCLUSIONS All the patients with deep dermatophytosis had autosomal recessive CARD9 deficiency. Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency. (Funded by Agence Nationale pour la Recherche and others.) PMID:24131138

Orbit determination support of the Ocean Topography Experiment (TOPEX)/Poseidon operational orbit

NASA Technical Reports Server (NTRS)

Schanzle, A. F.; Rovnak, J. E.; Bolvin, D. T.; Doll, C. E.

1993-01-01

The Ocean Topography Experiment (TOPEX/Poseidon) mission is designed to determine the topography of the Earth's sea surface over a 3-year period, beginning shortly after launch in July 1992. TOPEX/Poseidon is a joint venture between the United States National Aeronautics and Space Administration (NASA) and the French Centre Nationale d'Etudes Spatiales. The Jet Propulsion Laboratory is NASA's TOPEX/Poseidon project center. The Tracking and Data Relay Satellite System (TDRSS) will nominally be used to support the day-to-day orbit determination aspects of the mission. Due to its extensive experience with TDRSS tracking data, the NASA Goddard Space Flight Center (GSFC) Flight Dynamics Facility (FDF) will receive and process TDRSS observational data. To fulfill the scientific goals of the mission, it is necessary to achieve and maintain a very precise orbit. The most stringent accuracy requirements are associated with planning and evaluating orbit maneuvers, which will place the spacecraft in its mission orbit and maintain the required ground track. To determine if the FDF can meet the TOPEX/Poseidon maneuver accuracy requirements, covariance analysis was undertaken with the Orbit Determination Error Analysis System (ODEAS). The covariance analysis addressed many aspects of TOPEX/Poseidon orbit determination, including arc length, force models, and other processing options. The most recent analysis has focused on determining the size of the geopotential field necessary to meet the maneuver support requirements. Analysis was undertaken with the full 50 x 50 Goddard Earth Model (GEM) T3 field as well as smaller representations of this model.

Rotational Spectroscopy of Isocyanic Molecules: Allyl Isocyanide and Diisocyanomethane

NASA Astrophysics Data System (ADS)

Motiyenko, R. A.; Margules, L.; Haykal, I.; Huet, T. R.; Cocinero, E. J.; Ecija, P.; Fernandez, J. A.; Castano, F.; Lesarri, A.; Guillemin, J.-C.

2012-06-01

Isocyanides are less stable isomers of nitriles and some of them have already been observed in the interstellar medium (HNC, CH_3NC, HCCNC). But still there exists a lack of experimental spectroscopic data on simple isocyanic molecules that can represent potential astrophysical interest. In this view we have performed high resolution studies of rotational spectra of allyl isocyanide (CH_2=CH--CH_2--NC) and diisocyanomethane (CN--CH_2--NC). The rotational spectra of allyl isocyanide have been measured in the frequency range 6 -- 18 GHz by means of FTMW spectrometer in Bilbao and in the frequency range 150 -- 945 GHz by means of classic absorption spectroscopy in Lille. Two stable confomers of allyl isocyanide have been observed in both series of measurements. In addition, all 13C-monosubstituted isotopologues and 15N isotopologues were detected in natural abundance. Due to much lower kinetic stability the rotational spectrum of diisocyanomethane has been measured only in absorption using the Lille spectrometer. The spectral assignments have been supported by high-level quantum chemical calculations. For both molecules accurate sets of rotational and centrifugal distortion constants (up to the octics) have been produced. As a result, reliable predictions of transitions frequencies suitable for astrophysical detection have been obtained for both molecules. Finally, the effective and substitution structures were determined for the two conformers of allyl isocyanide, comparing the result with ab initio data. This work is supported by Centre Nationale d'Etudes Spatiales (CNES), Action sur Projet Physico-Chimie du Milieu Interstellaire (PCMI-CNRS) and by the contract ANR-08-BLAN-0054. Spanish part acknowledges funding from the MICINN and the MINECO.

Satellite remote sensing of hailstorms in France

NASA Astrophysics Data System (ADS)

Melcón, Pablo; Merino, Andrés; Sánchez, José Luis; López, Laura; Hermida, Lucía

2016-12-01

Hailstorms are meteorological phenomena of great interest to the scientific community, owing to their socioeconomic impact, which is mainly on agricultural production. With its global coverage and high spatial and temporal resolution, satellite remote sensing can contribute to monitoring of such events through the development of appropriate techniques. This paper presents an extensive validation in the south of France of a hail detection tool (HDT) developed for the Middle Ebro Valley (MEV). The HDT is based on consecutive application of two filters, a convection mask (CM) and hail mask (HM), using spectral channels of the Meteosat Second Generation (MSG) satellite. The south of France is an ideal area for studying hailstorms, because there is a robust database of hail falls recorded by an extensive network of hailpads managed by the Association Nationale d'Etude et de Lutte contre les Fleáux Atmosphériques (ANELFA). The results show noticeably poorer performance of the HDT in France relative to that in the MEV, with probability of detection (POD) 60.4% and false alarm rate (FAR) 26.6%. For this reason, a new tool to suit the characteristics of hailstorms in France has been developed. The France Hail Detection Tool (FHDT) was developed using logistic regression from channels of the Spinning Enhanced Visible and Infrared Imager (SEVIRI) sensor of the MSG. The FHDT was validated, resulting in POD 69.3% and FAR 15.4%, thus improving hail detection in the study area as compared with the previous tool. The new tool was tested in a case study with satisfactory results, supporting its future practical application.

Attitude of pregnant women towards HIV testing in Abidjan, Côte d'Ivoire and Bobo-Dioulasso, Burkina Faso. DITRAME Study Group (ANRS 049 Clinical Trial). Diminution de la Transmission Mère Enfant du VIH. Agence Nationale de Recherches sur le SIDA.

PubMed

Cartoux, M; Msellati, P; Meda, N; Welffens-Ekra, C; Mandelbrot, L; Leroy, V; Van de Perre, P; Dabis, F

1998-12-03

To evaluate the attitude of pregnant women towards HIV testing in two cities of West Africa: Abidjan, Côte d'Ivoire and Bobo-Dioulasso, Burkina Faso. In the context of a clinical trial to prevent HIV vertical transmission, HIV counselling and testing was offered systematically to women attending antenatal clinics. Informed consent was obtained and test results were given anonymously. Multiple logistic regression was performed to identify factors associated with refusal for testing and failure to return for test results. A total of 9724 pregnant women were interviewed from January 1995 to September 1996. In Abidjan (n=5766) and Bobo-Dioulasso (n=3958), 78 and 92.4% of the women consented to HIV testing, respectively, and 58.4 and 81.8% of them returned for the test results disclosure, respectively. In the two sites, the counsellors themselves and high educational level of the women appeared to be related to refusal of the test, whereas last trimester gestation was associated with failure to return for test results. In Abidjan, foreigners and employees were more likely to refuse testing, and HIV-infected women were three times less likely to return for results than uninfected women. Future implementation of interventions to reduce vertical transmission of HIV that require antenatal HIV testing and counselling will have to solve issue of acceptability of HIV testing by pregnant women.

Vitamin C supplement intake and postmenopausal breast cancer risk: interaction with dietary vitamin C.

PubMed

Cadeau, Claire; Fournier, Agnès; Mesrine, Sylvie; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine

2016-07-01

Experimental and epidemiologic studies have yielded conflicting results on the relation between vitamin C intake and breast cancer risk. We investigated the relation between vitamin C supplement intake and breast cancer risk while considering dietary vitamin C intake. Between 1995 and 2008, 2482 invasive breast cancer cases occurred in 57,403 postmenopausal women from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) prospective cohort during 581,085 person-years. We estimated vitamin C intake from foods with the use of a validated food-frequency questionnaire that was sent to subjects in 1993-1995 and vitamin C supplement use via questionnaires sent in 1995, 2000, 2002, and 2005. Multivariable HRs (95% CIs) for primary invasive breast cancer were estimated with the use of Cox regression models. All statistical tests were 2-sided. Vitamin C supplement use (ever compared with never) was not associated with breast cancer risk overall; it was associated with higher breast cancer risk in women in the fourth quartile of vitamin C intake from foods (HR: 1.32; 95% CI: 1.04, 1.67) but not in other quartiles of dietary vitamin C intake (P-interaction = 0.03). We observed that vitamin C supplement use was associated with increased postmenopausal breast cancer risk in women with high vitamin C intake from foods. Our data suggest a potential U- or J-shaped relation between total vitamin C intake and postmenopausal breast cancer risk that deserves further investigation. © 2016 American Society for Nutrition.

The Mysterious sdO X-ray Binary BD+37°442

NASA Astrophysics Data System (ADS)

Heber, U.; Geier, S.; Irrgang, A.; Schneider, D.; Barbu-Barna, I.; Mereghetti, S.; La Palombara, N.

2014-04-01

Pulsed X-ray emission in the luminous, helium-rich sdO BD +37°442 has recently been discovered (La Palombara et al. 2012). It was suggested that the sdO star has a neutron star or white dwarf companion with a spin period of 19.2 s. After HD 49798, which has a massive white dwarf companion spinning at 13.2 s in an 1.55 day orbit, this is only the second O-type subdwarf from which X-ray emission has been detected. We report preliminary results of our ongoing campaign to obtain time-resolved high-resolution spectroscopy using the CAFE instrument at Calar Alto observatory and SARG at the Telescopio Nationale Galileo. Atmospheric parameters were derived via a quantitative NLTE spectral analysis. The line fits hint at an unusually large projected rotation velocity. Therefore it seemed likely that BD +37°442 is a binary similar to HD 49798 and that the orbital period is also similar. The level of X-ray emission from BD +37°442 could be explained by accretion from the sdO wind by a neutron star orbiting at a period of less than ten days. Hence, we embarked on radial velocity monitoring in order to derive the binary parameters of the BD+37°442 system and obtained 41 spectra spread out over several month in 2012. Unlike for HD 49798, no radial velocity variations were found and, hence, there is no dynamical evidence for the existence of a compact companion yet. The origin of the pulsed X-ray emission remains as a mystery.

Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women.

PubMed

Vercambre, Marie-Noël; Boutron-Ruault, Marie-Christine; Ritchie, Karen; Clavel-Chapelon, Françoise; Berr, Claudine

2009-08-01

The objective of the present study was to determine the potential long-term impact of dietary habits on age-related decline among 4809 elderly women (born between 1925 and 1930) in the 'Etude Epidémiologique de Femmes de la Mutuelle Générale de l'Education Nationale' (E3N) study, a French epidemiological cohort. In 1993, an extensive diet history self-administered questionnaire was sent to all participants, and in 2006 another questionnaire on instrumental activities of daily living (IADL) and recent cognitive change was sent to a close relative or friend of each woman. Logistic models adjusted for socio-demographic, lifestyle and health factors were performed to evaluate associations between habitual dietary intakes and two outcomes of interest based on the informant response: recent cognitive decline and IADL impairment. Recent cognitive decline was associated with lower intakes of poultry, fish, and animal fats, as well as higher intakes of dairy desserts and ice-cream. IADL impairment was associated with a lower intake of vegetables. The odds of recent cognitive decline increased significantly with decreasing intake of soluble dietary fibre and n-3 fatty acids but with increasing intake of retinol. The odds of IADL impairment increased significantly with decreasing intakes of vitamins B2, B6 and B12. These results are consistent with a possible long-term neuroprotective effect of dietary fibre, n-3 polyunsaturated fats and B-group vitamins, and support dietary intervention to prevent cognitive decline.

[Which information is given during the purchase of an HIV self-test in a Caen pharmacy? A Comprehensive transversal and observational study using surveys, without modification of practice].

PubMed

Guitton, S; Rabiaza, A

2018-04-16

HIV infection affects about 150,000 people in France. In total, 30,000 of them are unaware of their serostatus. In this context, HIV self-testing has arrived in France in September 2015. The aim of our study was to analyze the level of application of the recommendations during the purchase of an HIV self-test. Our primary hypothesis was that the delivered information is poor. We realized a comprehensive transversal and observational study with surveys without modification of practice in all Caen pharmacies. The primary endpoint was the seller's assessment of the presence or possibility of an emergency situation requiring a post-exposure prophylaxis and suitability assessment of self-testing for the patient's case. Seven pharmacies out of the 41 visited (17.07%) validated our primary endpoint. In all pharmacies, 43.9% had HIV self-tests available for sale. The availabality of the self-tests is linked to the main endpoint (P<0.005). In total, 31.71% of the vendors redirected the patient to another method of screening (general practitioner, sexual health clinic…). The delivered information about HIV self-tests is poor. Improving it would put the pharmacist at the heart of the HIV screening strategy. The introduction of training for the professionnals in our region could be interesting to improve the dispensing of the self-tests. Copyright © 2018 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Paraneoplastic Cushing's syndrome, a real diagnostic and therapeutic challenge: A case report and literature review].

PubMed

Meftah, A; Moumen, A; Massine El Hammoumi, M; Hajhouji, S; El Jadi, H; Anas Guerboub, A; Elmoussaoui, S; Mayaudon, H; Hassane Kabiri, E; Hakkou, K; Belmejdoub, G

2015-12-01

Paraneoplastic Cushing's syndrome is a rare cause of endogenous hypercortisolism attributable to ectopic ACTH secretion by non-pituitary tumors. Imaging and biochemical results are often inconclusive and differential diagnosis with Cushing's disease can then be challenging. Moreover, these tumors may be occult and difficult to find and thus the need of new imaging tools such as (18)FDG-PET scan and (18)DOPA-PET scan. We report a 50-year-old man who presented with very aggressive clinical features related to Cushing's syndrome. Biological work-up confirmed the hypercortisolism and was consistent with an ectopic ACTH secretion. Conventional localization techniques failed to show any tumor and bilateral adrenalectomy was performed because of life-threatening complications. Two years later, thoracic computed tomography reveals an 11 mm mass in the left lower pulmonary lobe, (18)FDG-PET scan found a non-specific mild hypermetabolism of the lung nodule, and the (18)DOPA-PET scan confirmed the high uptake of this nodule suggesting an endocrine carcinoma. Histology confirmed a typical carcinoid tumor. The tumor cells stained positive for ACTH, CD56, chromogranin and synaptophysin. This case illustrates the dilemma between the need for morphological diagnosis of the ectopic ACTH source and control of the life-threatening hypercortisolism. (18)FDG-PET scan and (18)DOPA-PET scan should be considered early as a secondary diagnostic tool when conventional imagery fails to show any tumor. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Economic impact of etanercept and adalimumab biosimilars on hospitals scale covered by PharmAlp'Ain, a hospitals grouping of orders for health products].

PubMed

Berreur, B; Guerin, F; Christophe, B; Limido, G; Paubel, P

2018-01-01

To evaluate the economic impact of future prescriptions of etanercept and adalimumab biosimilars at the territorial scale covered by PharmAlp'Ain, a hospitals grouping of orders for health products. Determination of the number and status of patients (naive or in continuation of treatment) from the National Database "Datamart de Consommation Inter-Régimes" of health insurance, concerned by a dispensation in a pharmacy of etanercept or adalimumab in 2015. Calculation of potential savings in case of biosimilar requirements according to 3 hypotheses: 63% (rate observed in a previous study) of initiations are treated with biosimiliaries and the others by princeps (H 1 ); all initiations under biosimilars and continuation therapy with the princeps (H 2 ) or all patients are treated with biosimilars (H 3 ). The annual savings are estimated at 237,000 € with the H 1 hypothesis. In the case of H 2 , the expected savings would be 376,200 € per year. In the case of H 3 , savings for the community could reach almost 1,282,800 € per year. The arrival of biosimilars allows significant savings for medicines market. According to the French recommendations in 2016, the expected savings are between the H 1 and H 2 hypothesis. The rate of penetration of biosimilars depends on many factors such as the involvement of health professionals, patient adherence, or health authority recommendations. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[A pilot study of the professional ethical thinking of Quebec hospital pharmacists and pharmacy students].

PubMed

Guérin, A; Bussières, J-F

2017-01-01

The main objective was to assess the position of Quebec pharmaceutical community about pharmaceutical ethics statements. The second objective was to compare the level of agreement of pharmacy students and hospitals pharmacists. Survey conducted one day given in 2012 and 2013 for students in 2013 and from 29/08/2014 to 02/09/2014 for pharmacists. A questionnaire of eight themes and 43 statements was developed: training and education (5 questions), clinical research (7) advertising and marketing (5) evaluation (5) dispensing medication (4), pharmaceutical care (9) economic aspect (6) and code of ethics (2). A Likert scale with four choices was used to measure the level of agreement. The primary outcome was the difference between the level of agreement of pharmacy students and hospital pharmacists. The Chi 2  test was used. A total of 347 students and 398 pharmacists responded to the survey. There was a statistically significant difference regarding the level of agreement with 28 statements on 43. The differences focused on eight themes of the questionnaire, or training and education (3/5 significantly different questions), clinical research (2/7), advertising and marketing (2/5), Evaluation (4/5) dispensing medication (4/4), pharmaceutical care (5/9), economic aspect (6/6) and ethics (2/2). This study shows that there is a difference between pharmacists and pharmacy students about pharmaceutical ethics statements. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Adaptive Automation Triggered by EEG-Based Mental Workload Index: A Passive Brain-Computer Interface Application in Realistic Air Traffic Control Environment.

PubMed

Aricò, Pietro; Borghini, Gianluca; Di Flumeri, Gianluca; Colosimo, Alfredo; Bonelli, Stefano; Golfetti, Alessia; Pozzi, Simone; Imbert, Jean-Paul; Granger, Géraud; Benhacene, Raïlane; Babiloni, Fabio

2016-01-01

Adaptive Automation (AA) is a promising approach to keep the task workload demand within appropriate levels in order to avoid both the under - and over-load conditions, hence enhancing the overall performance and safety of the human-machine system. The main issue on the use of AA is how to trigger the AA solutions without affecting the operative task. In this regard, passive Brain-Computer Interface (pBCI) systems are a good candidate to activate automation, since they are able to gather information about the covert behavior (e.g., mental workload) of a subject by analyzing its neurophysiological signals (i.e., brain activity), and without interfering with the ongoing operational activity. We proposed a pBCI system able to trigger AA solutions integrated in a realistic Air Traffic Management (ATM) research simulator developed and hosted at ENAC (É cole Nationale de l'Aviation Civile of Toulouse, France). Twelve Air Traffic Controller (ATCO) students have been involved in the experiment and they have been asked to perform ATM scenarios with and without the support of the AA solutions. Results demonstrated the effectiveness of the proposed pBCI system, since it enabled the AA mostly during the high-demanding conditions (i.e., overload situations) inducing a reduction of the mental workload under which the ATCOs were operating. On the contrary, as desired, the AA was not activated when workload level was under the threshold, to prevent too low demanding conditions that could bring the operator's workload level toward potentially dangerous conditions of underload.

Safety and immunogenicity of a live recombinant canarypox virus expressing HIV type 1 gp120 MN MN tm/gag/protease LAI (ALVAC-HIV, vCP205) followed by a p24E-V3 MN synthetic peptide (CLTB-36) administered in healthy volunteers at low risk for HIV infection. AGIS Group and L'Agence Nationale de Recherches sur Le Sida.

PubMed

Salmon-Céron, D; Excler, J L; Finkielsztejn, L; Autran, B; Gluckman, J C; Sicard, D; Matthews, T J; Meignier, B; Valentin, C; El Habib, R; Blondeau, C; Raux, M; Moog, C; Tartaglia, J; Chong, P; Klein, M; Milcamps, B; Heshmati, F; Plotkin, S

1999-05-01

A live recombinant canarypox vector expressing HIV-1 gpl20 MN tm/gag/protease LAI (ALVAC-HIV, vCP205) alone or boosted by a p24E-V3 MN synthetic peptide (CLTB-36) was tested in healthy volunteers at low risk for HIV infection for their safety and immunogenicity. Both antigens were well tolerated. ALVAC-HIV (vCP205) induced low levels of neutralizing antibodies against HIV-1 MN in 33% of the volunteers. None of them had detectable neutralizing antibodies against a nonsyncytium-inducing HIV-1 clade B primary isolate (Bx08). After the fourth injection of vCP205, CTL activity was detected in 33% of the volunteers and was directed against Env, Gag, and Pol. This activity was mediated by both CD4+ and CD8+ lymphocytes. On the other hand, the CLTB-36 peptide was poorly immunogenic and induced no neutralizing antibodies or CTLs. Although the ALVAC-HIV (vCP205) and CLTB-36 prime-boost regimen was not optimal, further studies with ALVAC-HIV (vCP205) are warranted because of its clear induction of a cellular immune response and utility as a priming agent for other subunit antigens such as envelope glycoproteins, pseudoparticles, or new peptides.

Lead exposure from food: the German LExUKon project.

PubMed

Schneider, Klaus; Schwarz, Markus A; Lindtner, Oliver; Blume, Katrin; Heinemeyer, Gerhard

2014-01-01

Lead is a highly toxic contaminant with food being the major source of exposure for the general public. The second German food consumption survey (Nationale Verzehrsstudie II - NVS II) with about 20 000 participants (15 371 for dietary history interviews used for this study) allowed for an updated exposure assessment for the German population. Based on these comprehensive data, information on consumption of 545 individual food items by the German population was generated. Lead concentrations in food were compiled from the German food monitoring programme, European countries' authority programmes and the published literature, covering the years from 2000 to 2009, and were multiplied with consumption data to obtain estimates of lead intake from food. Average lead concentrations per main food group were highest for meat (including offal), followed by fish (including seafood), vegetables and cereals. Due to high consumption, beverages contributed most to the intake of the general public, followed by main groups vegetables, fruits & nuts and cereals. Lead intake from food was estimated to be 0.53 and 0.72 µg kg(-1) bw and day for average and high-end consumers, respectively. This is close to (average consumers) respectively above (high-end consumers) a reference value derived from a recent health risk evaluation performed by EFSA, using the benchmark approach. Uncertainties in these estimates pertain to the influence of values below the limit of quantification and some foods not considered due to lacking occurrence data. In conclusion, the estimated lead intake of the German population from food is still close to health-based reference values. Further efforts to reduce lead intake are required.

[Diagnostic value of selective anorexia in pathological weight loss].

PubMed

Braquet, P; Mercier, G; Reynes, J; Jeandel, C; Pinzani, V; Guilpain, P; Rivière, S; Le Quellec, A

2016-02-01

The diagnostic value of selective anorexia is debated. Some authors have suggested an association between meat aversion and cancer, but most do not use it as a diagnostic tool. We aimed to characterize anorexia of different diseases to search for an association between selective aversions and diagnostic groups. All the patients admitted to three departments of a teaching hospital were included consecutively for 22months if they had more than 10 % weight loss in less than one year. Patients were excluded if history taking was not reliable, or if they suffered from anorexia nervosa. We compiled diagnoses at discharge and validated them six months later. We used logistic regression to identify independent factors associated with selective anorexia. Inclusion criteria were met in 106patients (female 44 %, median age 65years). Most frequent diagnoses were: cancer (36 %), infection (35 %), digestive diseases (19 %), non organic diseases (21 %). Recent selective anorexia was found in 46 % of the cases. It was significantly associated with female gender (P=0.002), marginally with young age (P=0.069) and long duration of weight loss (P=0.079). Opioid use at admission was negatively associated with selective anorexia (P=0.001). No specific diagnostic category was found to be associated. Selective anorexia does not appear to be a useful symptom to investigate pathological weight loss. It behaves more like a non-specific reactivation by current disease of earlier latent personal food aversions. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Adaptive Automation Triggered by EEG-Based Mental Workload Index: A Passive Brain-Computer Interface Application in Realistic Air Traffic Control Environment

PubMed Central

Aricò, Pietro; Borghini, Gianluca; Di Flumeri, Gianluca; Colosimo, Alfredo; Bonelli, Stefano; Golfetti, Alessia; Pozzi, Simone; Imbert, Jean-Paul; Granger, Géraud; Benhacene, Raïlane; Babiloni, Fabio

2016-01-01

Adaptive Automation (AA) is a promising approach to keep the task workload demand within appropriate levels in order to avoid both the under- and over-load conditions, hence enhancing the overall performance and safety of the human-machine system. The main issue on the use of AA is how to trigger the AA solutions without affecting the operative task. In this regard, passive Brain-Computer Interface (pBCI) systems are a good candidate to activate automation, since they are able to gather information about the covert behavior (e.g., mental workload) of a subject by analyzing its neurophysiological signals (i.e., brain activity), and without interfering with the ongoing operational activity. We proposed a pBCI system able to trigger AA solutions integrated in a realistic Air Traffic Management (ATM) research simulator developed and hosted at ENAC (École Nationale de l'Aviation Civile of Toulouse, France). Twelve Air Traffic Controller (ATCO) students have been involved in the experiment and they have been asked to perform ATM scenarios with and without the support of the AA solutions. Results demonstrated the effectiveness of the proposed pBCI system, since it enabled the AA mostly during the high-demanding conditions (i.e., overload situations) inducing a reduction of the mental workload under which the ATCOs were operating. On the contrary, as desired, the AA was not activated when workload level was under the threshold, to prevent too low demanding conditions that could bring the operator's workload level toward potentially dangerous conditions of underload. PMID:27833542

[Perspective of the transition from reusable instruments to single use ancillary in orthopedic surgery].

PubMed

Steelandt, J; Vaillant, T; Duhamel, C; Haghighat, S; Féron, J-M; Paubel, P; Cordonnier, A-L

2018-03-01

Since 2009, single-use (SU) ancillaries for total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been marketed to replace reusable ancillaries. The concept is not innovative but their use in orthopedics is still uncommon. An assessment has been done for the use of SU ancillary in Assistance publique-hôpitaux de Paris with the consequences for the patient, the surgeon and the hospital. A technical and a clinical review has been done with those devices in 2015. The economic and organizational impacts were identified and submitted for opinion to committee experts in orthopedics. Three SU ancillaries are commercialized. No clinical studies are currently available. There is no reimbursement for SU ancillaries whereas reusable ancillaries are included in prosthesis reimbursement price. Although SU ancillaries (TKA and THA) saving costs for sterilization, the annual additional budget estimated for their purchase would approximately be 2.5 times higher. Nevertheless, indirect savings could be also considered in the long-term period (global costs for sterilization, volume effect…). For the same quality, according to the experts, organizational impacts are low for the patient and the surgeon but potentially important for the hospital, the nursing and pharmaceutical staff, and logistical activities. On logistic, clinical and financial aspects, SU ancillaries need more evaluation. The switch to SU ancillaries allows saving sterilization costs and time, and provided an immediate mobilization of the equipment but their interest must be demonstrated by clinical and economic data. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Tranexamic acid as first-line emergency treatment for episodes of bradykinin-mediated angioedema induced by ACE inhibitors].

PubMed

Beauchêne, C; Martins-Héricher, J; Denis, D; Martin, L; Maillard, H

2018-05-04

Episodes of acquired bradykinin-mediated angioedema due to angiotensin-converting enzyme (ACE) inhibitors may result in fatal outcomes. There is no consensus regarding emergency pharmacological management of these episodes. Treatment options include icatibant and C1INH concentrate. Tranexamic acid is administered for moderate episodes. Its efficacy in the treatment of ACE inhibitor-induced episodes of angioedema is not established. The aim of this retrospective study is to assess the benefits of emergency tranexamic acid administration in the management of ACE inhibitor-induced episodes of angioedema. Retrospective analysis of the medical files of patients who consulted between 2010 and 2016 in two French tertiary care hospitals for a bradykinic angioedema attributed to an ACE treatment. All of them had received tranexamic acid as a first line treatment. Thirty three patients who had experienced severe episode of angioedema were included. Twenty seven patients showed significant improvement when treated with tranexamic acid alone. The six remaining patients were treated with icatibant (5/33) or C1INH concentrate (1/33), due to partial improvement after tranexamic acid therapy. None of the patients were intubated, no fatalities were recorded and no side effects were reported. Tranexamic acid is an easily accessible and affordable therapy that may provide effective treatment for ACE inhibitor-induced episodes of angioedema. It may help while waiting for a more specific treatment (icatibant and C1INH concentrate) that is at times unavailable in emergency departments. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Can shale safely host US nuclear waste?

USGS Publications Warehouse

Neuzil, C.E.

2013-01-01

"Even as cleanup efforts after Japan’s Fukushima disaster offer a stark reminder of the spent nuclear fuel (SNF) stored at nuclear plants worldwide, the decision in 2009 to scrap Yucca Mountain as a permanent disposal site has dimmed hope for a repository for SNF and other high-level nuclear waste (HLW) in the United States anytime soon. About 70,000 metric tons of SNF are now in pool or dry cask storage at 75 sites across the United States [Government Accountability Office, 2012], and uncertainty about its fate is hobbling future development of nuclear power, increasing costs for utilities, and creating a liability for American taxpayers [Blue Ribbon Commission on America’s Nuclear Future, 2012].However, abandoning Yucca Mountain could also result in broadening geologic options for hosting America’s nuclear waste. Shales and other argillaceous formations (mudrocks, clays, and similar clay-rich media) have been absent from the U.S. repository program. In contrast, France, Switzerland, and Belgium are now planning repositories in argillaceous formations after extensive research in underground laboratories on the safety and feasibility of such an approach [Blue Ribbon Commission on America’s Nuclear Future, 2012; Nationale Genossenschaft für die Lagerung radioaktiver Abfälle (NAGRA), 2010; Organisme national des déchets radioactifs et des matières fissiles enrichies, 2011]. Other nations, notably Japan, Canada, and the United Kingdom, are studying argillaceous formations or may consider them in their siting programs [Japan Atomic Energy Agency, 2012; Nuclear Waste Management Organization (NWMO), (2011a); Powell et al., 2010]."

[Nocardiosis: A retrospective case series of 19 patients].

PubMed

Le Coustumier, E M; Denes, E; Martin, C; Weinbreck, P

2017-02-01

Nocardiosis are uncommon. The diagnosis may be difficult, with significant morbidity and mortality, often occurring on frail patients. Few data are available in France. A retrospective single center study was conducted from 2002 to 2014 and included all patients with at least one positive microbiological sample for Nocardia with a follow-up in our hospital. Nineteen patients, including 15 men, were included with a mean age of 58 years (25-85). Seventeen had a risk factor (lung diseases [13], corticosteroids [12], solid neoplasia [2], HIV infection [2], diabetes mellitus [3], kidney transplant [2], lymphopenia [1]). Infections' locations were: pulmonary (12), brain (3), skin (2), lymph node (1) and corneal (1). The slow growth leads to a median of 35 days for a positive result (3-95). Nine species were identified. Fifteen patients (79%) received one or more lines of antibiotics including: cotrimoxazole (9), amoxicillin (7) cefotaxime/ceftriaxone (7) imipenem (3), or amikacin (3). The average duration of antibiotic therapy was 207 days. Four patients did not receive antibiotics due to a late result or a bacterial co-infection masking nocardiosis. Five patients died (26%) including 2 with cerebral nocardiosis. Six patients were cured, 4 suffered a relapse, 4 had an unknown evolution, and 1 was still treated. Our study shows that nocardiosis is a disease difficult to treat. A better understanding of this type of infection is necessary. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Observational and Modeling-based Study of Corsica Thunderstorms: Preparation of the EXAEDRE Airborne Campaign

NASA Astrophysics Data System (ADS)

Defer, E.; Coquillat, S.; Lambert, D.; Pinty, J. P.; Prieur, S.; Caumont, O.; Labatut, L.; Nuret, M.; Blanchet, P.; Buguet, M.; Lalande, P.; Labrouche, G.; Pedeboy, S.; Lojou, J. Y.; Schwarzenboeck, A.; Delanoë, J.; Bourdon, A.; Guiraud, L.

2017-12-01

The 4-year EXAEDRE (EXploiting new Atmospheric Electricity Data for Research and the Environment; Oct 2016-Sept 2020) project is sponsored by the French Science Foundation ANR (Agence Nationale de la Recherche). This project is a French contribution to the HyMeX (HYdrological cycle in the Mediterranean EXperiment) program. The EXAEDRE activities rely on innovative multi-disciplinary and state of the art instrumentation and modeling tools to provide a comprehensive description of the electrical activity in thunderstorms. The EXAEDRE observational part is based on i) existing lightning records collected during HyMeX Special Observation Period (SOP1; Sept-Nov 2012), and permanent lightning observations provided by the research Lightning Mapping Array SAETTA and the operational Météorage lightning locating systems, ii) additional lightning observations mapped with a new VHF interferometer especially developed within the EXAEDRE project, and iii) a dedicated airborne campaign over Corsica. The modeling part of the EXAEDRE project exploits the electrification and lightning schemes developed in the cloud resolving model MesoNH and promotes an innovative technique of flash data assimilation in the french operational model AROME of Météo-France. An overview of the EXAEDRE project will be given with an emphasis on the instrumental, observational and modeling activities performed during the 1st year of the project. The preparation of the EXAEDRE airborne campaign scheduled for September 2018 over Corsica will then be discussed. Acknowledgements. The EXAEDRE project is sponsored by grant ANR-16-CE04-0005 with support from the MISTRALS/HyMeX meta program.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lites, B.W.; Skumanich, A.

OSO 8 observations of the profiles of the resonance lines of H I, Mg II, and Ca II obtained with the Laboratorie de Physique Stellaire et Planetaire de Centre National de la Recherche Scientifique (LPSP-CNRS) spectrometer (by A.S.) and of C IV obtained with the University of Colorado (CU) spectrometer (by B.W.L.) for a large quiet sunspot (1975 November 16--17) are analyzed along with near-simultaneous ground-based Stokes measurements obtained in a collaborative arrangement with L. L. House and T. Baur (HAO-NCAR) to yield an umbral chromosphere and transition region model. Features of this model include: (1) a chromosphere that ismore » effectively thin in the important chromsopheric resonance lines of H I and Mg II and saturated in Ca II; (2) an upper chromospheric structure similar to quiet-Sun models; (3) penetration of the sunspot photospheric ''cooling wave'' to higher altitudes in the sunspot chromosphere than in quiet-Sun models, i.e., a more extended temperature minimum region in the sunspot atomphere; (4) a lower pressure corona above the sunspot umbra than above a typical quiet region; (5) very low nonthermal broadening in the umbral chromosphere; (6) a moderately strong downdraft; (7) chromospheric radiative loss rates not significantly different from their corresponding quiet-Sun values; (8) a temperature gradient in the transitons region near 10/sup 5/ Kapprox.0.1 times the corresponding quiet-Sun value. The Balmer continuum radiation from the photospheric areas outside the sunspot umbra controls the hydrogen ionization, and hence the electron density, in the chromosphere above the umbra.« less

Sharing is Winning: Cooperative Learning about Atmospheric Composition Change

NASA Astrophysics Data System (ADS)

Schuepbach, E.

2010-09-01

This contribution presents evolving good practice in disseminating the body of know-how, skills and competencies within the networked community of atmospheric scientists as established in ACCENT. The promotion of early-career scientists, and encouraging the next generation to move into the field were among the key issues addressed by the "Training and Education" programme in the European Network of Excellence in Atmospheric Composition Change (ACCENT). Dissemination avenues include a virtual knowledge train carrying the wealth of high-quality scientific learning material developed with experts involved in the ACCENT network. Learning opportunities on current research in atmospheric composition change in Europe were also created during face-to-face training workshops. Real-life examples of pressing air quality issues were addressed in meetings with stakeholder groups that offered opportunities for mutual learning in inspiring partnerships. In order to increase the expertise in atmospheric composition change across Europe, activities were organized with the general public (e.g., Café Scientifique), where the participating early-career scientists were confronted with questions from lay people. For interested teachers, didactic translations of compact overviews on air quality science topics developed in ACCENT offer links with the typical European science curriculum and go beyond school book content. Some of the educational events, methods and tools are described in a booklet published in 2009 ("We Care for Clean Air!", ISBN 978-88-95665-01-6). The electronic version and all training material can be downloaded from www.accent-network.org/portal/education - a valuable resource for teachers and learners around the globe.

The BNM-LPTF software for the frequency comparison of atomic clocks by the carrier phase of the GPS signal.

PubMed

Taris, F; Uhrich, P; Petit, G; Jiang, Z; Barillet, R; Hamouda, F

2000-01-01

This paper describes the software and equipment used at the Laboratoire Primaire du Temps et des Frequences du Bureau National de Metrologie (BNM-LPTF), Paris, France. Two H-masers in short baseline, one located at the BNM-LPTF and the other at the Laboratoire de l'Horloge Atomique du Centre National de la Recherche Scientifique (CNRS-LHA), Orsay, France, were computed in parallel with the BNM-LPTF software and with the BERNESE V 4.1 software. The comparison of the results issued from both computations shows an agreement within 100 ps (1 sigma). In addition, comparisons with the BNM-LPTF software were made over 10 days with the H-masers located at the Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany, and another at the National Physical Laboratory (NPL), Teddington, United Kingdom. The data collected show that a modulation with an amplitude of 50 ps and a period of 700-800 ps affects the equipment of the NPL. In addition, these comparisons show that the noise of the instruments together with the environmental conditions at the PTB was higher than that of the NPL and the BNM-LPTF during the observation period. The best relative frequency stability obtained, in the BNM-LPTF/NPL comparison, is about 3x10(-15) for averaging periods between 6x10(4) s and 3x10(5) s. This result is in good agreement with the expected stability of H-masers. It demonstrates that the noise brought by the GPS carrier phase measurements can be averaged out at this level.

Evidence for an Accretion Origin for the Outer Halo Globular Cluster System of M31

NASA Astrophysics Data System (ADS)

Mackey, A. D.; Huxor, A. P.; Ferguson, A. M. N.; Irwin, M. J.; Tanvir, N. R.; McConnachie, A. W.; Ibata, R. A.; Chapman, S. C.; Lewis, G. F.

2010-07-01

We use a sample of newly discovered globular clusters from the Pan-Andromeda Archaeological Survey (PAndAS) in combination with previously cataloged objects to map the spatial distribution of globular clusters in the M31 halo. At projected radii beyond ≈30 kpc, where large coherent stellar streams are readily distinguished in the field, there is a striking correlation between these features and the positions of the globular clusters. Adopting a simple Monte Carlo approach, we test the significance of this association by computing the probability that it could be due to the chance alignment of globular clusters smoothly distributed in the M31 halo. We find that the likelihood of this possibility is low, below 1%, and conclude that the observed spatial coincidence between globular clusters and multiple tidal debris streams in the outer halo of M31 reflects a genuine physical association. Our results imply that the majority of the remote globular cluster system of M31 has been assembled as a consequence of the accretion of cluster-bearing satellite galaxies. This constitutes the most direct evidence to date that the outer halo globular cluster populations in some galaxies are largely accreted. Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii.

Abundance analysis of roAp stars. IV. HD24712

NASA Astrophysics Data System (ADS)

Ryabchikova, T. A.; Landstreet, J. D.; Gelbmann, M. J.; Bolgova, G. T.; Tsymbal, V. V.; Weiss, W. W.

1997-11-01

We present the first abundance analysis of the rapidly oscillating chemically peculiar star HD24712, and determine a T_eff,=7250K, log {g},=4.3, and xi_t ,=1kms(-1) . Microturbulence seems to be entirely simulated by a magnetic field with a polar field strength of 4.4kG and of dipolar structure, both of which are supported by our polarimetric observations. Rotation of HD24712 and a spotty surface distribution of the elements result in different mean abundances for different (magnetic) phases. Our results do not support the hypothesis of a monotonic correlation between the amplitude of abundance variations and the atomic number Z, and we present arguments in favour of one of the rotation periods (Prot=12\\fd 4610) discussed in the literature. Rare earth elements are the most overabundant elements relative to the sun, and they have the largest abundance amplitude during a rotation cycle; only Mg has a larger amplitude. For HD24712 we find a clear overabundance of Co while most of the other iron peak elements are underabundant. A comparison of the abundance pattern with the other three roAp stars analyzed so far by us concludes the paper. A systematic difference between surface gravities obtained from spectroscopy and from both asteroseismology and evolutionary tracks is found for the roAp stars HD 24712, alpha Cir, and gamma Equ. Based on observations obtained with the Canada-France-Hawaii telescope, operated by the National Research Council of Canada, the Centre Centre National de la Recherche Scientifique de France, and the University of Hawaii, and on observations obtained at CARSO, Las Campanas, Chile

Cretaceous to Tertiary paleogeographic reconstructions of the Alps-Pyrenees linking zone

NASA Astrophysics Data System (ADS)

Frasca, Gianluca; Dielforder, Armin; Ford, Mary; Vergés, Jaume

2017-04-01

The northwestern Mediterranean subduction systems underwent an important phase of reorganization between Late Cretaceous and Eocene. The mode and timing of this reorganization are still under debate. Great uncertainties mainly derive from the poorly preserved record of the early phases of orogenic evolution in both the Alps and Pyrenees and the distruction of the orogenic system between the Pyrenees and Alps by the Oligo-Miocene opening of the Gulf of Lion due to backarc rifting. Vestiges are nevertheless preserved in the Pyreneo-Provençal fold-and-thrust belt and associated basins in southern France and Corsica-Sardinia. In this work we first review published plate kinematic models for Iberia, Apulia and Europe from 83 Ma, focusing in particular on the restoration of the Corso-Sardinia block using the free software GPlates. Second, we characterize the Upper Cretaceous to Eocene depositional systems at the junction between the Alps, Pyrenees and Apennines, reviewing previous paleogeographic restorations for the Western Alpine and Eastern Pyrenean foreland basins. Last, we compare the kinematic models with reconstructed basin dynamics. We critically assess the implications of newly proposed paleogeographic reconstructions (at 83, 65, 50, 37 and 30 Ma) for the validity of various plate kinematic models. The information derived from the sedimentary basins help to define the mode and timing of the subduction reorganization that occurred between 83 and 30 Ma in the northwestern Mediterranean. This study is part of the Orogen research program funded by Total, the BRGM (Bureau de Recherches Géologiques et Minières), the CNRS (Centre National de la Recherche Scientifique).

A new phase of activity of the Herbig Be star HD 200775 in 2001: Evidence for binarity

NASA Astrophysics Data System (ADS)

Pogodin, M. A.; Miroshnichenko, A. S.; Tarasov, A. E.; Mitskevich, M. P.; Chountonov, G. A.; Klochkova, V. G.; Yushkin, M. V.; Manset, N.; Bjorkman, K. S.; Morrison, N. D.; Wisniewski, J. P.

2004-04-01

The results of high-resolution spectroscopy of the Herbig Be star HD 200775 obtained within the framework of a cooperative observing programme in 2000-2002 are presented. A new high-activity phase of the object's Hα line occurred in the middle of 2001 in full agreement with a 3.68-year periodicity predicted by Miroshnichenko et al. (\\cite{mirosh}). A complicated picture of the Hα line profile variability near the activity maximum phase turned out to be very similar to that observed during the previous one in 1997. Variations of the radial velocity with the activity phase are detected in He I, Si II, and S II photospheric lines. The observed phenomena are interpreted in the framework of a model in which the star, together with its gaseous envelope, is a component of an eccentric binary system. A preliminary orbital solution is derived, and the system's parameters are estimated from the radial velocity curves of the Hα emission line. We find that the orbital eccentricity is e ˜0.3, the mean companion separation is ˜1000 R⊙, and the secondary companion is most likely to be a ˜3.5 M⊙ pre-main sequence object. We emphasize the importance of coordinated spectroscopic and interferometric observations at different phases of the object's activity for further understanding the properties of the system. Partially based on observations collected at the Canada-France-Hawaii telescope (CFHT), operated by the National Research Council of Canada, the Centre National de la Recherche Scientifique, and University of Hawaii.

Homogeneous spectroscopic parameters for bright planet host stars from the northern hemisphere . The impact on stellar and planetary mass

NASA Astrophysics Data System (ADS)

Sousa, S. G.; Santos, N. C.; Mortier, A.; Tsantaki, M.; Adibekyan, V.; Delgado Mena, E.; Israelian, G.; Rojas-Ayala, B.; Neves, V.

2015-04-01

Aims: In this work we derive new precise and homogeneous parameters for 37 stars with planets. For this purpose, we analyze high resolution spectra obtained by the NARVAL spectrograph for a sample composed of bright planet host stars in the northern hemisphere. The new parameters are included in the SWEET-Cat online catalogue. Methods: To ensure that the catalogue is homogeneous, we use our standard spectroscopic analysis procedure, ARES+MOOG, to derive effective temperatures, surface gravities, and metallicities. These spectroscopic stellar parameters are then used as input to compute the stellar mass and radius, which are fundamental for the derivation of the planetary mass and radius. Results: We show that the spectroscopic parameters, masses, and radii are generally in good agreement with the values available in online databases of exoplanets. There are some exceptions, especially for the evolved stars. These are analyzed in detail focusing on the effect of the stellar mass on the derived planetary mass. Conclusions: We conclude that the stellar mass estimations for giant stars should be managed with extreme caution when using them to compute the planetary masses. We report examples within this sample where the differences in planetary mass can be as high as 100% in the most extreme cases. Based on observations obtained at the Telescope Bernard Lyot (USR5026) operated by the Observatoire Midi-Pyrénées and the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique of France (Run ID L131N11 - OPTICON_2013A_027).

Prescrire du cannabis fumé pour la douleur chronique non cancéreuse

PubMed Central

Kahan, Meldon; Srivastava, Anita; Spithoff, Sheryl; Bromley, Lisa

2014-01-01

Résumé Objectif Offrir des conseils préliminaires sur la prescription de cannabis fumé pour la douleur chronique avant la publication de lignes directrices officielles. Qualité des données Nous avons examiné les ouvrages scientifiques sur l’efficacité analgésique du cannabis fumé et les dommages causés par la consommation de cannabis à des fins médicales et récréatives. Nous avons élaboré des recommandations concernant les indications et les contre-indications du cannabis fumé, les précautions à prendre et son dosage et nous avons classé les recommandations en fonction du niveau des données probantes. La plupart des données probantes sont de niveau II (études observationnelles bien effectuées) et de niveau III (opinion d’experts). Message principal Le cannabis fumé pourrait être indiqué chez des patients souffrant de douleurs neuropathiques sévères qui n’ont pas répondu à des essais suffisants de cannabinoïdes pharmaceutiques et d’analgésiques standards (données probantes de niveau II). Le cannabis fumé est contre-indiqué chez les patients de 25 ans ou moins (données probantes de niveau II); ceux qui font actuellement ou ont fait par le passé une psychose ou encore ont de forts antécédents familiaux de psychose (données probantes de niveau II); ceux qui ont ou ont eu un problème de consommation de cannabis (données probantes de niveau III); ceux qui ont un problème actuel de toxicomanie ou d’alcoolisme (données probantes de niveau III); ceux qui ont une maladie cardiovasculaire ou respiratoire (données probantes de niveau III); ou celles qui sont enceintes ou planifient une grossesse (données probantes de niveau II). Il devrait être utilisé avec précaution par les patients qui fument du tabac (données probantes de niveau II), qui sont à risque accru de maladies cardiovasculaires (données probantes de niveau III), qui ont des troubles d’anxiété ou de l’humeur (données probantes de niveau II) ou qui prennent de fortes doses d’opioïdes ou de benzodiazépines (données probantes de niveau III). Il faut conseiller aux utilisateurs de cannabis d’attendre au moins 3 à 4 heures avant de conduire s’ils en ont fumé, au moins 6 heures s’ils en ont consommé par la bouche et au moins 8 heures s’ils ont ressenti un «high» subjectif (données probantes de niveau II). La dose maximale recommandée est de 1 inhalation 4 fois par jour (environ 400 mg par jour) de cannabis séché contenant 9 % de delta-9-tétrahydrocannabinol (données probantes de niveau III)). Les médecins devraient éviter de demander une consultation pour les patients auprès de cliniques «cannabinoïdes» (données probantes de niveau III). Conclusion Les lignes directrices futures devraient se fonder sur une révision systématique des ouvrages scientifiques sur la sécurité et l’efficacité du cannabis fumé. D’autres recherches sont nécessaires sur l’efficacité et la sécurité à long terme du cannabis fumé par rapport à d’autres cannabinoïdes pharmaceutiques, aux opioïdes et à d’autres analgésiques standards.

Nutrient profiles discriminate between foods according to their contribution to nutritionally adequate diets: a validation study using linear programming and the SAIN,LIM system.

PubMed

Darmon, Nicole; Vieux, Florent; Maillot, Matthieu; Volatier, Jean-Luc; Martin, Ambroise

2009-04-01

The nutrient profile concept implies that it is possible to discriminate between foods according to their contribution to a healthy diet on the basis of their nutrient contents only. The objective was to test the compatibility between nutrient profiling and nutrient-based recommendations by using diet modeling with linear programming. Food consumption data from the French "Individuelle et Nationale sur les Consommations Alimentaires" dietary survey and its associated food-composition database were used as input data. Each food was allocated to 1 of 4 classes, according to the SAIN,LIM system -- a nutrient profiling system based on 2 independent scores, including a total of 8 basic plus 4 optional nutrients. The possibility to model diets fulfilling a set of 40 nutrient recommendations (healthy models) was tested by using foods from a given nutrient profile class only or from a combination of classes. The possibility to fulfill a set of nutrient constraints in contradiction with the recommendations (unhealthy models) was also tested. For each model, the feasible energy range was assessed by minimizing and maximizing total energy content. With foods from the most favorable nutrient profile class, healthy diets could be modeled, but it was impossible to design unhealthy diets within a realistic range of energy intake with these foods. With foods from the least favorable class, unhealthy, but not healthy, diets could be designed. Both healthy and unhealthy diets could be designed with foods from intermediate classes. On the basis of a few key nutrients, it is possible to predict the ability of a given food to facilitate -- or to impair -- the fulfillment of a large number of nutrient recommendations.

[Inventory of training of internal medicine in France: Results of a national survey].

PubMed

Samson, M; Terrier, B; Mangin, O; Mouthon, L

2017-05-01

To make an inventory of training of Internal Medicine in France. This study was conducted between May and September 2015 with coordinators (interviews of 45minutes) of local Internal Medicine training and fellows (online questionnaire). All coordinators (n=28) responded to the interviews. Local training of Internal Medicine exists in 86% of regions (3.1±3.1hours/month) and an interregional training in all interregions (34.7±13.9hours/year). When excluding Île-de-France, no correlation between the number of teachers and the amount of lessons was noted (P=0.61). Of the 550 fellows in Internal Medicine in 2014-2015, 223 (41%) responded to the online questionnaire. Mean level was 5.5±2.7 semesters. The rate of satisfaction (1=very dissatisfied and 5=very satisfied) was 3.0±1.0 and 3.8±0.8 for regional and interregional teaching, respectively (P<0.0001). Regional teaching satisfaction was correlated with the perceived expanse of diseases covered into the program (P<0.0001). In addition, 89% of fellows wish to evaluate themselves online, 66% wish to have a practical evaluation at the bedside and 70% in simulation centers. Finally, 91% of fellows support the establishment of a national program for the training of Internal Medicine. This survey states for the first time an inventory of training of Internal Medicine dedicated to fellows in France. This report highlights that fellows wish to have a national program, be further evaluated and have access to more interactive approach of teaching. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Death certificate data in France: Production process and main types of analyses].

PubMed

Rey, G

2016-10-01

Mortality data, by the unambiguity of their definition and understanding by all stakeholders, and completeness of registration, are a cornerstone of public health statistics in France and in most industrialized countries. This article describes the data production process, and the main types of possible analyses. Data production is composed of different stages: death certification by a medical doctor on paper or electronic (using a web application) format, data transmission to Inserm, capture and coding of information. The encoding of the information follows the WHO recommendations of the International Classification of Diseases ([ICD], 10th revision used since 2000). It is carried out using an automatic coding software, called Iris, developed in an international consortium. The coding aims, first, at assigning an ICD code to all nosologic entities encountered on the certificate, and then at selecting the underlying cause of death. The latter is the main information used for statistical analyses. Three main types of analysis emerge in the literature: the exploitation of data on the death certificate only, ecological analyses (studies of associations between variables measured across groups) and analysis from data individually linked to other databases. Many public health issues can be addressed with these various analyses. Several developments in the production process are being implemented: the deployment of electronic certification, increased automation of the death certificate information processing and durable and complete record linkage with health insurance and hospitalisation data. They could soon be deeply expanding the scope of possible uses of causes of death data. Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Atmospheric Measurements by Cavity Enhanced Absorption Spectroscopy

NASA Astrophysics Data System (ADS)

Yi, Hongming; Wu, Tao; Coeur-Tourneur, Cécile; Fertein, Eric; Gao, Xiaoming; Zhao, Weixiong; Zhang, Weijun; Chen, Weidong

2015-04-01

Since the last decade, atmospheric environmental monitoring has benefited from the development of novel spectroscopic measurement techniques owing to the significant breakthroughs in photonic technology from the UV to the infrared spectral domain [1]. In this presentation, we will overview our recent development and applications of cavity enhanced absorption spectroscopy techniques for in situ optical monitoring of chemically reactive atmospheric species (such as HONO, NO3, NO2, N2O5) in intensive campaigns [2] and/or in smog chamber studies [3]. These field deployments demonstrated that modern photonic technologies (newly emergent light sources combined with high sensitivity spectroscopic techniques) can provide a useful tool to improve our understanding of tropospheric chemical processes which affect climate, air quality, and the spread of pollution. Experimental detail and preliminary results will be presented. Acknowledgements. The financial support from the French Agence Nationale de la Recherche (ANR) under the NexCILAS (ANR-11-NS09-0002) and the CaPPA (ANR-10-LABX-005) contracts is acknowledged. References [1] X. Cui, C. Lengignon, T. Wu, W. Zhao, G. Wysocki, E. Fertein, C. Coeur, A. Cassez,L. Croisé, W. Chen, et al., "Photonic Sensing of the Atmosphere by absorption spectroscopy", J. Quant. Spectrosc. Rad. Transfer 113 (2012) 1300-1316 [2] T. Wu, Q. Zha, W. Chen, Z. XU, T. Wang, X. He, "Development and deployment of a cavity enhanced UV-LED spectrometer for measurements of atmospheric HONO and NO2 in Hong Kong", Atmos. Environ. 95 (2014) 544-551 [3] T. Wu, C. Coeur-Tourneur, G. Dhont,A. Cassez, E. Fertein, X. He, W. Chen,"Application of IBBCEAS to kinetic study of NO3 radical formation from O3 + NO2 reaction in an atmospheric simulation chamber", J. Quant. Spectrosc. Rad. Transfer 133 (2014)199-205

Development and validation of a quantitative competitive ELISA for potency testing of equine anti rabies sera with other potential use.

PubMed

Korimbocus, Jehanara; Dehay, Nicolas; Tordo, Noël; Cano, François; Morgeaux, Sylvie

2016-06-14

In case of a bite by a rabies infected animal, the World Health Organisation recommends a prophylactic treatment including the administration of Human Rabies Immunoglobulins (HRIGs) or highly purified F(ab')2 fragments produced from Equine Rabies Immunoglobulin (F(ab')2 - ERIGs). According to international regulation, quality control of F(ab')2 - ERIGs lots requires potency testing by the in vivo Mouse Neutralisation Test (MNT) prior marketing. However, the strategy of the 3Rs (Reduce, Refine, Replace) for animal testing required by the European Directive encourages the replacement of the in vivo potency test by an in vitro assay. In this context, a competitive ELISA method (c-ELISA) has been developed by the Agence Nationale de Sécurité du Médicament et des Produits de Santé where F(ab')2 - ERIGs are in competition with a monoclonal antibody recognizing the trimeric native form of the rabies glycoprotein. After a full validation study, the c-ELISA has been applied to commercial batches of F(ab')2 - ERIGs. A correlation study with the MNT demonstrated a similarity between the two methods (r=0.751). Moreover, the c-ELISA method which does not need any species specific reagent has been applied to HRIGs potency testing as an alternative method to Rapid Fluorescent Focus Inhibition Test (RFFIT), thus avoiding the handling of live rabies virus in BSL3 containment. In conclusion, the c-ELISA has shown its potential to replace MNT and possibly RFFIT for the quantification of rabies immunoglobulin. After optimisation it may be used for the quantification of rabies immunoglobulin in any animal species, notably for rabies immunogenicity assay in mice. Copyright © 2016 Elsevier Ltd. All rights reserved.

A cross-sectional comparison between the perception of physicians and pharmacists concerning the role of the pharmacist in physician training.

PubMed

Béchet, C; Pichon, R; Giordan, A; Bonnabry, P

2018-05-22

This study aimed to identify and compare physician-pharmacist perceptions concerning drug teaching to physicians by pharmacists in Swiss hospital settings. Questionnaires were emailed to all French-speaking physicians (survey A) and pharmacists (survey B) working in Swiss hospitals where medical directors/chief-pharmacists had approved the study. Questions were developed based on previous physician interviews. Most questions used four Likert-type response alternatives. A Mann-Whitney U test was used to compare answers to survey A and B. Fourteen out of 18 medical directors and 16/16 chief-pharmacists gave permission for the study. In total, 244 (11%) physicians answered survey A, and 115 (74%) pharmacists answered survey B. Nearly all participants agreed that pharmacists should take part in both medical student and physician postgraduate training. Most physicians answered wanting additional training and pharmacists are unaware of this need. Only two thirds of physicians reported having acquired knowledge about drugs thanks to pharmacists; document diffusion and direct answers to their questions having contributed the most to their training. Participants agreed that physician training by pharmacists needs a clearer delineation regarding the type of training, its aim, its targeted public, when and what pharmaceutical benefits are used. Physicians' priority-training topics are high-risk drugs, novelties and areas in which they consider their basic training was insufficient. Methods preferred for training are: case studies; exercises with individual corrections; and group work. Improved resources and planning are needed to meet physicians' expectations. Training is often carried out implicitly, through activities with various other aims, and needs to be better defined and formalized collaboratively. Copyright © 2018 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Hailstorm forecast from stability indexes in Southwestern France

NASA Astrophysics Data System (ADS)

Melcón, Pablo; Merino, Andrés; Sánchez, José Luis; Dessens, Jean; Gascón, Estíbaliz; Berthet, Claude; López, Laura; García-Ortega, Eduardo

2016-04-01

Forecasting hailstorms is a difficult task because of their small spatial and temporal scales. Over recent decades, stability indexes have been commonly used in operational forecasting to provide a simplified representation of different thermodynamic characteristics of the atmosphere, regarding the onset of convective events. However, they are estimated from vertical profiles obtained by radiosondes, which are usually available only twice a day and have limited spatial representativeness. Numerical models predictions can be used to overcome these drawbacks, providing vertical profiles with higher spatiotemporal resolution. The main objective of this study is to create a tool for hail prediction in the southwest of France, one of the European regions where hailstorms have a higher incidence. The Association Nationale d'Etude et de Lutte contre les Fleáux Atmosphériques (ANELFA) maintains there a dense hailpad network in continuous operation, which has created an extensive database of hail events, used in this study as ground truth. The new technique is aimed to classify the spatial distribution of different stability indexes on hail days. These indexes were calculated from vertical profiles at 1200 UTC provided by WRF numerical model, validated with radiosonde data from Bordeaux. Binary logistic regression is used to select those indexes that best represent thermodynamic conditions related to occurrence of hail in the zone. Then, they are combined in a single algorithm that surpassed the predictive power they have when used independently. Regression equation results in hail days are used in cluster analysis to identify different spatial patterns given by the probability algorithm. This new tool can be used in operational forecasting, in combination with synoptic and mesoscale techniques, to properly define hail probability and distribution. Acknowledgements The authors would like to thank the CEPA González Díez Foundation and the University of Leon for its financial support.

The neutron channeling phenomenon.

PubMed

Khanouchi, A; Sabir, A; Boulkheir, M; Ichaoui, R; Ghassoun, J; Jehouani, A

1997-01-01

Shields, used for protection against radiation, are often pierced with vacuum channels for passing cables and other instruments for measurements. The neutron transmission through these shields is an unavoidable phenomenon. In this work we study and discuss the effect of channels on neutron transmission through shields. We consider an infinite homogeneous slab, with a fixed thickness (20 lambda, with lambda the mean free path of the neutron in the slab), which contains a vacuum channel. This slab is irradiated with an infinite source of neutrons on the left side and on the other side (right side) many detectors with windows equal to 2 lambda are placed in order to evaluate the neutron transmission probabilities (Khanouchi, A., Aboubekr, A., Ghassoun, J. and Jehouani, A. (1994) Rencontre Nationale des Jeunes Chercheurs en Physique. Casa Blanca Maroc; Khanouchi, A., Sabir, A., Ghassoun, J. and Jehouani, A. (1995) Premier Congré International des Intéractions Rayonnements Matière. Eljadida Maroc). The neutron history within the slab is simulated by the Monte Carlo method (Booth, T. E. and Hendricks, J. S. (1994) Nuclear Technology 5) and using the exponential biasing technique in order to improve the Monte Carlo calculation (Levitt, L. B. (1968) Nuclear Science and Engineering 31, 500-504; Jehouani, A., Ghassoun, J. and Aboubker, A. (1994) In Proceedings of the 6th International Symposium on Radiation Physics, Rabat, Morocco). Then different geometries of the vacuum channel have been studied. For each geometry we have determined the detector response and calculated the neutron transmission probability for different detector positions. This neutron transmission probability presents a peak for the detectors placed in front of the vacuum channel. This study allowed us to clearly identify the neutron channeling phenomenon. One application of our study is to detect vacuum defects in materials.

Antioxidant and antimicrobial proprieties of chitin and chitosan extracted from Parapenaeus Longirostris shrimp shell waste.

PubMed

Hafsa, J; Smach, M A; Charfeddine, B; Limem, K; Majdoub, H; Rouatbi, S

2016-01-01

Chitosan, the linear polymer, is produced by alkali deacetylation of chitin (CHI). Recently chitin and chitosan were attracted marked interest due to their biocompatibility, biodegradability and non-toxicity. In this study, chitin was extracted from shrimp shell (Parapenaeus longirostris) and chitosan was deacetylated by classical and ultrasound-assisted method. The identification of functional groups and the determination of degree of deacetylation of chitin (CHI), classical deacetylated chitosan (CDC) and ultrasound-assisted deacetylated chitosan (UDC) were carried through Fourier Transform-Infrared Spectroscopy. Their antimicrobial and antioxidant activity were also investigated. The degree of deacetylation of CHI, CDC and UDC is 33.64%, 73.68% and 83.55%, respectively. Results showed that CHI, CDC and UDC exhibited a good antimicrobial activity against (S. aureus, E. coli, P. aeruginosa, K. pneumonia) and (C. albicans and C. parapsilosis). The scavenging ability of CHI, CDC and UDC on 1,1-diphenyl-2-picrylhydrazyl radicals is ranging from 4.71% to 21.25%, 11.45% to 32.78% and 18.27% to 44.17%, respectively, at the concentrations of 0.25 to 1mg/mL. The inhibition of lipid peroxidation with thiobarbituric acid-reacting substances is ranging from 11.7% to 51.63%, 17.24% to 63.52% and 29.31% to 77.39%, respectively, at varying concentrations of 0.25 to 1mg/mL. The effectiveness of CHI, CDC and UDC is correlated with their degree of deacetylation. The results indicate the possibility of exploiting chitin and chitosan as antimicrobial agent. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

A Secular Variation Model for Igrf-12 Based on Swarm Data and Inverse Geodynamo Modelling

NASA Astrophysics Data System (ADS)

Fournier, A.; Aubert, J.; Erwan, T.

2014-12-01

We are proposing a secular variation candidate model for the 12th generation of the international geomagnetic reference field, spanning the years 2015-2020. The novelty of our approach stands in the initialization of a 5-yr long integration of a numerical model of Earth's dynamo by means of inverse geodynamo modelling, as introduced by Aubert (GJI, 2014). This inverse technique combines the information coming from the observations (in the form of an instantaneous estimate of the Gauss coefficients for the magnetic field and its secular variation) with that coming from the multivariate statistics of a free run of a numerical model of the geodynamo. The Gauss coefficients and their error covariance properties are determined from Swarm data along the lines detailed by Thébault et al. (EPS, 2010). The numerical model of the geodynamo is the so-called Coupled Earth Dynamo model (Aubert et al., Nature, 2013), whose variability possesses a strong level of similarity with that of the geomagnetic field. We illustrate and assess the potential of this methodology by applying it to recent time intervals, with an initialization based on CHAMP data, and conclude by presenting our SV candidate, whose initialization is based on the 1st year of Swarm data This work is supported by the French "Agence Nationale de la Recherche" under the grant ANR-11-BS56-011 (http://avsgeomag.ipgp.fr) and by the CNES. References: Aubert, J., Geophys. J. Int. 197, 1321-1334, 2014, doi: 10.1093/gji/ggu064 Aubert, J., Finlay, C., Fournier, F. Nature 502, 219-223, 2013, doi: 10.1038/nature12574 Thébault E. , A. Chulliat, S. Maus, G. Hulot, B. Langais, A. Chambodut and M. Menvielle, Earth Planets Space, Vol. 62 (No. 10), pp. 753-763, 2010.

[Critical analysis of reference studies on aluminium-based adjuvants toxicokinetics].

PubMed

Masson, J-D; Crépeaux, G; Authier, F-J; Exley, C; Gherardi, R K

2017-07-01

We reviewed the three reference toxicokinetic studies commonly used to suggest innocuity of aluminum (Al)-based adjuvants. A single experimental study was carried out using isotopic 26 Al (Flarend et al., 1997). This study ignored adjuvant cell capture. It was conducted over a short period of time (28 days) and used only two rabbits per adjuvant. At the endpoint, Al retention was 78% for aluminum phosphate and 94% for aluminum hydroxide, both results being incompatible with quick elimination of vaccine-derived Al in urines. Tissue distribution analysis omitted three important retention sites: the injected muscle, the draining lymph node and bone. Two theoretical studies have evaluated the potential risk of vaccine Al in infants, by reference to the oral Minimal Risk Level (MRL) extrapolated from animal studies. Keith et al., 2002 used a too high MRL (2mg/kg/d), an erroneous model of 100% immediate absorption of vaccine Al, and did not consider renal and blood-brain barrier immaturity. Mitkus et al. (2011) only considered absorbed Al, with erroneous calculations of absorption duration. They ignored particulate Al captured by immune cells, which play a role in systemic diffusion and the neuro-inflammatory potential of the adjuvant. MRL they used was both inappropriate (oral Al vs injected adjuvant) and far too high (1mg/kg/d) with regard to experimental studies of Al-induced memory and behavioral changes. Both paucity and serious weaknesses of these studies strongly suggest that novel experimental studies of Al adjuvants toxicokinetics should be performed on the long-term, including post-natal and adult exposures, to ensure innocuity and restore population confidence in Al-containing vaccines. Copyright © 2017 Académie Nationale de Pharmacie. All rights reserved.

[Cryopyrin-associated periodic syndromes].

PubMed

Quartier, P; Rodrigues, F; Georgin-Lavialle, S

2018-04-01

Cryopyrin-associated periodic syndromes (CAPS) are linked to one single gene mutations, however they are associated with 3 syndromes, which are, from the mildest to the most severe phenotype familial cold urticaria, Muckle-Wells syndrome and chronic, infantile, neurologic, cutaneous, articular (CINCA) syndrome also called neonatal-onset multisystem inflammatory disease (NOMID). Autosomic dominant inheritance is present in most cases but in CINCA/NOMID syndrome where neomutations are more common. Mutations in the gene encoding cryopyrin, NLRP3, are associated with deregulation of caspase-1 activity, excessive interleukin-1 production and an autoinflammatory syndrome, which in familial cold urticaria and Muckle-Wells syndrome may be triggered or worsened by exposure to coldness. More and more mutations are described and even somatic mutations that can explain some clinical signs beginning in adulthood. Patients disclose a pseudo-urticarial rash, arthralgia, headaches, sometimes fever, biological inflammation but also, in severe forms of the disease, neurologic inflammation with central deafness, ophthalmologic inflammation, chronic meningitis. Some CINCA/NOMID patients also develop growth cartilage pseudo-tumoral hypertrophy. Natural disease history is usually benign in familial cold urticarial but severe in the other forms, particularly regarding neuro-sensorial involvement. In addition, secondary AA amyloidosis may develop in all forms in the absence of control of chronic inflammation. Anti-interleukin-1 treatment with anakinra, rilonacept or canakinumab induces in most cases complete remission, however sequelae may be present, particularly if central deafness or cartilage bone hypertrophy have already developed. This treatment is also important to prevent secondary amyloidosis or stabilize and even sometimes allow improvement of amyloidosis lesions. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Preparation and efficacy assessment of malva nut polysaccharide for skin hydrating products.

PubMed

Kanlayavattanakul, M; Fungpaisalpong, K; Pumcharoen, M; Lourith, N

2017-11-01

Scaphium scaphigerum or malva nut has long been served in Chinese medicine. However, the use of this herb in modern health care applications has, to date, been rarely reported. Maceration of the herb in water afforded malva nut polysaccharide which was standardized. Safety and skin hydrating efficacy of the polysaccharide and products were evaluated in human volunteers. Malva nut polysaccharide (41.71±0.64%) having 36.58±0.51% total sugar content was isolated, with further analysis quantifying ash, carbohydrate, reducing sugar and moisture contents to be 6.05±0.00, 40.06±1.00, 12.20±0.05 and 12.64±0.31%, respectively. The polysaccharide exhibited swelling and hydrating capacities of 0.46±0.01% and 54.46±0.02g/g, with L*, a* and b* of 52.56±0.04, 9.02±0.06 and 18.42±0.03, respectively, and a viscosity of 1263.00±2.00 cps. Accelerated testing indicated the biopolysaccharide to be stable, resulting in no skin irritation in 15 human volunteers. The skin hydrating efficacy as assessed via a randomized single-blind, placebo-controlled study in 24 volunteers highlighted the superior performance of malva nut over the vehicle (moisture retainment for 70min as examined by Corneometer ® CM 825). A stable skin moisturizing gel containing malva nut was developed and was shown to exhibit improved performance over benchmark tamarind and algae polysaccharide gels (after 180min observation). Malva nut polysaccharide has potential as a key ingredient in skin hydrating products, which should encourage its further development. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Day hospital in internal medicine: A chance for ambulatory care].

PubMed

Grasland, A; Mortier, E

2018-04-16

Internal medicine is an in-hospital speciality. Along with its expertise in rare diseases, it shares with general medicine the global care of patients but its place in the ambulatory shift has yet to be defined. The objective of our work was to evaluate the benefits of an internal medicine day-hospital devoted to general medicine. Named "Centre Vi'TAL" to underline the link between the city and the hospital, this novel activity was implemented in order to respond quickly to general practitioners having difficulties to synthesize their complex patients or facing diagnostic or therapeutic problems. Using preferentially email for communication, the general practitioners can contact an internist who is committed to respond on the same day and take over the patient within 7 days if day-hospital is appropriate for his condition. The other patients are directed either to the emergency department, consultation or full hospitalization. In 14 months, the center has received 213 (144 women, 69 men) patients, mean age 53.6, addressed by 88 general practitioners for 282 day-hospital sessions. Requests included problem diagnoses (n=105), synthesis reviews for complex patients (n=65), and treatment (n=43). In the ambulatory shift advocated by the authorities, this experience shows that internal medicine should engage in the recognition of day-hospital as a place for diagnosis and synthesis reviews connected with the city while leaving the general practitioners coordinator of their patient care. This activity of synthesis in day-hospital is useful for the patients and efficient for our healthcare system. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Dietary intake, physical activity and nutritional status in adults: the French nutrition and health survey (ENNS, 2006-2007).

PubMed

Castetbon, Katia; Vernay, Michel; Malon, Aurélie; Salanave, Benoit; Deschamps, Valérie; Roudier, Candice; Oleko, Amivi; Szego, Emmanuelle; Hercberg, Serge

2009-09-01

The French National Programme on Nutrition and Health (Programme national nutrition santé (PNNS)), the aim of which is to reduce nutrition-related chronic diseases, necessitates monitoring of nutritional characteristics. Our objective was to describe dietary intake, physical activity and nutritional status in a national sample of adults, especially according to current French recommendations. The study is based on a cross-sectional population-based survey using a multistage sampling design (Etude nationale nutrition santé (ENNS)). Between February 2006 and March 2007, 3115 18-74-year-old adults were included (participation rate 59.7 %). Energy, macronutrient and food consumption were estimated through three randomly distributed 24 h recalls, and compared to PNNS recommendations; physical activity was described using International Physical Activity Questionnaire guidelines; anthropometry, blood pressure and biochemical measurements were assessed according to national and international references. When compared to current recommendations, intake of carbohydrates (>50 % energy intake without alcohol: 26.4 %), SFA ( < 35 % total lipids: 18.5 %) and total fibre (>25 g/d: 13.7 %) was frequently unsatisfactory. While overall consumption of 'meat, seafood and eggs' was satisfactory, that of fruits and vegetables ( > or = 400 g/d: 43.8 %) and seafood (two or more servings per week: 29.9 %) was frequently too low. The physical activity level was satisfactory at 63.2 %. Overweight was observed in 49.3 % of adults, while 30.9 % were hypertensive and 44.1 % had dyslipidaemia. Vitamin and iron-poor status was found to affect less than 10 % of the population. Based on the ENNS survey, overall nutrition remains a problem in France. Comparison of these data with those of other countries could contribute to a better understanding of variations in nutrition-related diseases.

[Glucocorticoid therapy: what is the information sought by patients? Traffic analysis of the website cortisone-info.fr].

PubMed

Poisson, J; Six, M; Morin, C; Fardet, L

2013-05-01

About 1% of the general population are receiving systemic glucocorticoids. The information about this treatment sought by patients is unknown. The website www.cortisone-info.fr aims to provide therapeutic information about glucocorticoids and glucocorticoid therapy. It was posted on January 16, 2012. The information available on the website is documented and based on the recent medical literature. The website is made of 43 pages divided into five main sections (generalities about glucocorticoids, adverse events, measures associated with glucocorticoid therapy, discontinuation of glucocorticoids and, situations requiring attention). The website traffic between February 1st, 2012 and January 4, 2013 was analyzed using Google Analytics. During the study period, the website was visited by 67,496 people (average number of visitors per day: 33 in February 2012, 326 in December 2012). The number of page views was 230,496 or an average of 3.5 pages per visitor. Of these 230,496 page views, 145,431 (63.1%) were related to adverse events and 37,722 (16.4%) were related to generalities about glucocorticoids (e.g., what is cortisone? For which disease? How does it work?). Information particularly sought by visitors was related to the diet to follow during glucocorticoid therapy (page accessed 11,946 times), data about what cortisone is (page accessed 11,829 times) and the effects of glucocorticoids on weight (page accessed 10,442 times). Knowledge of glucocorticoid-treated patients' expectations may help physicians to optimize information they give, thereby helping to reduce patients' concerns about glucocorticoids and to improve adherence to the treatment. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Pathway to diagnosis and real-life experience of patients believing they are affected by "chronic Lyme disease"].

PubMed

Forestier, E; Gonnet, F; Revil-Signorat, A; Zipper, A C

2018-04-26

Chronic Lyme disease is a subject of scientific and social controversy in both Europe and the United States. The aim of our study was to analyze the pathway to diagnosis of patients believing they were affected by the disease, and to describe their real-life experience. A qualitative study was performed with 13 patients declaring themselves to be affected by chronic Lyme disease. Interviews were analyzed by 2 general medical practice interns, supervised by a general practitioner with a diploma in socio-anthropology and an infectious diseases specialist. Internet and other media played a major role in informing the patients or their doctor about the existence and the characteristics of chronic Lyme disease. The diagnosis was confirmed by features considered objective (chronic infection by Borrelia, tick bite, positive serology, beneficial or worsening effects of antibiotics). The long medical diagnosis and treatment process of those interviewed was marked by a conflicted relationship with the medical profession, caused by a feeling of non-recognition and abandonment. They reported their experience as being very painful, both because of the physical pain and also the psychological consequences of their condition. Improving the diagnosis and therapeutic management of patients believing themselves to be affected by chronic Lyme disease appears highly necessary both to limit their search for diagnosis and their experience of pain. It could be based on existing guidelines concerning medically unexplained symptoms to which the chronic Lyme disease issue appears quite similar on several points. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Improvement of the recruitment of surgery interns derived from the Epreuves Nationales Classantes (National-Ranking Exam): practical solution applied to urology].

PubMed

Beley, Sébastien; Dubosq, Francis; Simon, Pascal; Larré, Stéphane; Battisti, Simon; Ballereau, Charles; Boublil, Véronique; Richard, François; Rouprêt, Morgan

2005-12-01

To analyse the value of an urology initiation session proposed to young interns to improve recruitment of the discipline since the introduction of the new National-Ranking Exam (NRE). In October 2004, the 77 interns appointed to surgery in Paris on the basis of the ENC participated in a one-day urology initiation session organized by the AFUF, at the AP-HP School of Surgery. All interns were given a questionnaire at the beginning of the session to record the following data: age, gender, teaching hospital, a student attachment in urology and desired specialization as a function of the surgical training programmes proposed by the ENC. Items concerning the desired specialization were resubmitted to the interns at the end of the session. Population. 77 interns, 48 females (62.3%) and 29 males (37.7%) with a mean age of 25.2 +/- 5 years (range: 23-31). 55 interns had trained at a Parisian teaching hospital (67%) and 22 (28.6%) had trained at a provincial teaching hospital. 16 interns (20.8%) had completed at least one urology attachment during their medical training. Desired specialization. Orthopaedics was the discipline most frequently cited (n = 20; 26%). Urology was chosen by 8 interns (10.40%), who had all completed an urology attachment during their medical training. At the end of the urology initiation session, another 8 interns expressed the desire to specialize in urology. Of the 16 potential urology interns, 9 (56.2%) confirmed that their decision was final. Urology occupies a special place and remains a popular surgical speciality among students. Organization of practical sessions constitutes a solution to inform, create an emulation and motivate surgery interns to choose urology.

Prototype pushing robot for emplacing vitrified waste canisters into horizontal disposal drifts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Londe, L.; Seidler, W.K.; Bosgiraud, J.M.

2007-07-01

Within the French Underground Disposal concept, as described in ANDRA's (Agence Nationale pour la Gestion des Dechets Radioactifs) Dossier 2005, the Pushing Robot is an application envisaged for the emplacement (and the potential retrieval) of 'Vitrified waste packages', also called 'C type packages'. ANDRA has developed a Prototype Pushing Robot within the framework of the ESDRED Project (Engineering Studies and Demonstration of Repository Design) which is co-funded by the European Commission as part of the sixth EURATOM Research and Training Framework Programme (FP6) on nuclear energy (2002 - 2006). The Rationale of the Pushing Robot technology comes from various considerations,more » including the need for (1) a simple and robust system, capable of moving (and potentially retrieving) on up to 40 metres (m), a 2 tonne C type package (mounted on ceramic sliding runners) inside the carbon steel sleeve constituting the liner (and rock support) of a horizontal disposal cell, (2) small annular clearances between the package and the liner, (3) compactness of the device to be transferred from surface to underground, jointly with the package, inside a shielding cask, and (4) remote controlled operations for the sake of radioprotection. The initial design, based on gripping supports, has been replaced by a 'technical variant' based on inflatable toric jacks. It was then possible, using a test bench, to check that the Pushing Robot worked properly. Steps as high as 7 mm were successfully cleared by a dummy package pushed by the Prototype.. Based on the lessons learned by ANDRA's regarding the Prototype Pushing Robot, a new Scope of Work is being written for the Contract concerning an Industrial Scale Demonstrator. The Industrial Scale Demonstration should be completed by the end of the second Quarter of 2008. (authors)« less

[Use of a Delphi survey to assess the hospital economic impact of innovative products: The example of idarucizumab a dabigatran-specific reversal agent].

PubMed

Jamet, N; Thivilliers, A P; Paubel, P; Chevalier, D; Bourguignon, S; Bézie, Y

2017-11-01

The economic impact of therapeutic innovations on the hospital patient management cannot be easily estimated. The objective of this study is to illustrate the use of a Delphi survey as a support tool to identify the changes following the use of idarucizumab in dabigatran-treated patients with uncontrolled/life-threatening bleeding or who required emergency surgery/urgent procedures. The Delphi questionnaires have been administrated to 8 emergency physicians or anesthetists from 6 different hospital centers. Following the answers, an economic valorization has been carried out on every parameter on which a consensus was reached (at least 4 answers showing an identical trend). A mean management cost for each etiology with and without the use of idarucizumab has thus been identified. For gastro-intestinal and other life-threatening bleedings (excepted intracranial bleedings), the total management cost of the hospital stay was respectively 6058 € (-35%) and 6219 € (-34%) following the use of the reversal agent. The hospital management cost for intracranial bleeding is slightly increasing to 9790 € (+3%). The cost of a stay for emergency surgery decreases to 6962€ (-2%). This study shows a positive economic impact following the use of the dabigatran-specific reversal agent for patients with uncontrolled/life-threatening bleeding excepted in the case of intracranial bleeding. Moreover, it points out that a Delphi survey is an easy way to predict the hospital economic impact of a therapeutic innovation when no other evaluation is possible. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[Appropriateness of the prescriptions of conventional versus new oral anticoagulants at discharge from a department of internal medicine].

PubMed

Bochatay, L; Beney, J; Jordan-von Gunten, V; Petignat, P A; Roulet, L

2016-09-01

The recently introduced oral direct anticoagulants (ODAs), presumably safer, and with comparable efficacy to the vitamin K antagonists (VKAs), may reshape the world of anticoagulation medicine. This study aimed to assess the prescription appropriateness of ODAs and VKAs at discharge from hospital. We performed a one year retrospective study between August 2012 and July 2013 in the department of internal medicine of a regional hospital (HVs Sion) using Electronic Medical Records. All patients receiving an ODA were included and matched to a patient treated with a VKA. The appropriateness of prescription at discharge was defined by an adequate indication and dosing, the absence of contraindication, a minimal risk of drug-drug interactions and no major bleeding or venous thromboembolism during the hospitalization. The bleeding risk was evaluated with the HAS-BLED score when the indication was atrial fibrillation (AF). Out of the 44patients included (22 with an ODA and 22 with a VKA), 38 received an appropriate prescription according to all criteria. Two patients had an inadequate dosing. A potential drug-drug interaction was detected in 3patients receiving a VKA and in 1patient receiving an ODA. No major contraindication was found, but a relative contraindication was discussed in 3cases. The majority of patients receiving an ODA for an AF had a minor bleeding risk. No significant difference was ascertained between the two groups regarding the appropriateness of prescription. Our results suggest that ODAs were cautiously used in our setting. Copyright © 2015 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Survey of the prescriptions of proton pump inhibitors in patients admitted in an internal medicine ward: how is the compliance to the French guidelines?].

PubMed

Sauvaget, L; Rolland, L; Dabadie, S; Desblaches, J; Bernard, N; Vandenhende, M-A; Bonnet, F; Pédeboscq, S; Morlat, P

2015-10-01

In June 2009, the national French authority for Health reported many off-label uses of proton pump inhibitors (PPI). Our objective was to analyse the justification and modalities of PPI prescriptions in patients before their admission in a department of internal medicine. Data were prospectively collected during 5months. At admission, all prescriptions of PPI by general practitioners (GP) were recorded. The accordance of the prescriptions with the marketing authorization indications and the French guidelines in terms of duration of treatment or dosage was analyzed. These informations were obtained from computerized medical records and, if necessary, by contacting GPs. We collected 173 prescriptions. Fifty-six (32%) were in accordance with marketing authorization indications and, among them, 15 prescriptions (9% of all) respected the French guidelines about dosage and duration of treatment. One hundred and six prescriptions (61%) were not adequate and among them an off-label use was notified in 91 (53% of all); among them 33% for simple dyspeptic disorders, 23% for the prevention of NSAID-induced lesions in patients without risk factors, and finally 17% for the prevention of stress ulcer. Fifty-two prescriptions (30%) were unclassified due to incomplete data. Our study showed that a vast majority of the prescriptions for PPIs are not in accordance with French guidelines. Preventive actions against abusive prescriptions, withdrawal strategies or replacement of already prescribed PPIs should be implemented to reduce the risk of side effects and the economic impact of long term use of PPIs. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

A novel stability-indicating UPLC method development and validation for the determination of seven impurities in various diclofenac pharmaceutical dosage forms.

PubMed

Azougagh, M; Elkarbane, M; Bakhous, K; Issmaili, S; Skalli, A; Iben Moussad, S; Benaji, B

2016-09-01

An innovative simple, fast, precise and accurate ultra-high performance liquid chromatography (UPLC) method was developed for the determination of diclofenac (Dic) along with its impurities including the new dimer impurity in various pharmaceutical dosage forms. An Acquity HSS T3 (C18, 100×2.1mm, 1.8μm) column in gradient mode was used with mobile phase comprising of phosphoric acid, which has a pH value of 2.3 and methanol. The flow rate and the injection volume were set at 0.35ml·min(-1) and 1μl, respectively, and the UV detection was carried out at 254nm by using photodiode array detector. Dic was subjected to stress conditions from acid, base, hydrolytic, thermal, oxidative and photolytic degradation. The new developed method was successfully validated in accordance to the International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantitation, precision, linearity, accuracy and robustness. The degradation products were well resolved from main peak and its seven impurities, proving the specificity power of the method. The method showed good linearity with consistent recoveries for Dic content and its impurities. The relative percentage of standard deviation obtained for the repeatability and intermediate precision experiments was less than 3% and LOQ was less than 0.5μg·ml(-1) for all compounds. The new proposed method was found to be accurate, precise, specific, linear and robust. In addition, the method was successfully applied for the assay determination of Dic and its impurities in the several pharmaceutical dosage forms. Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Vigie Ciel a collaborative project to study fireballs and organise meteorite recoveries

NASA Astrophysics Data System (ADS)

Colas, F.; Zanda, B.; Bouley, S.; Lewin, E.; Vaubaillon, J.; Marmo, C.; Rotaru, M.; Labenne, L.; Julien, J. F.; Linares, M.; Steinhausser, A.; Rault, J. L.; Vernazza, P.

2015-10-01

Research on fireballs and meteorites has always been of interest to the public, due to the beauty of shooting stars in the night sky and to the extraterrestrial origin of meteorites. A fireball observation network called FRIPON [1] (Colas et al, 2015) is currently being setup, funded by ANR (Agence Nationale pour la Recherche). It will cover France with 100 cameras and is expected to be operational for the end of 2015. FRIPON will detect fireballs and hence allow us to define meteorite strewn fields within 24h, so that meteorite searches can be launched very early on. Because of the need to search all over France, including in private land, it is important that the general public be aware of our project and be willing to help or participate. Indeed, as the main goal of FRIPON is to recover fresh meteorites (within a few days), our aim is to be able to organize a search with at least 50 persons to scan an area of a few km2 within a week. Help from the public would hence be most helpful but it is also important to have an operational and trained research team. This project thus appears as a unique occasion to involve the public in a scientific project while promoting informal scientific education. This prompted us to set up Vigie-Ciel, a citizen science network centered on meteorite recovery. FRIPON is an open network based on open-source software, it will accept citizenrun cameras. In addition to fireballs, it will allow scientists and Vigie-Ciel participants to study anything that can be observed by all-sky cameras: bird migrations, bats, clouds, lightning, etc. The data will be freely available to all.

[Autoantibody profile in myositis].

PubMed

Allenbach, Y; Benveniste, O

2014-07-01

Patients suffering from muscular symptoms or with an increase of creatine kinase levels may present a myopathy. In such situations, clinicians have to confirm the existence of a myopathy and determine if it is an acquired or a genetic muscular disease. In the presence of an acquired myopathy after having ruled out an infectious, a toxic agent or an endocrine cause, physicians must identify which type of idiopathic myopathy the patient is presenting: either a myositis including polymyositis, dermatomyositis, and inclusion body myositis, or an immune-mediated necrotizing myopathy. Histopathology examination of a muscle biopsy is determinant but detection of autoantibody is now also crucial. The myositis-specific antibodies and myositis-associated antibodies lead to a serologic approach complementary to the histological classification, because strong associations of myositis-specific antibodies with clinical features and survival have been documented. The presence of anti-synthetase antibodies is associated with an original histopathologic pattern between polymyositis and dermatomyositis, and defines a syndrome where interstitial lung disease drives the prognosis. Anti-MDA-5 antibody are specifically associated with dermatomyositis, and define a skin-lung syndrome with a frequent severe disease course. Anti-TIF1-γ is also associated with dermatomyositis but its presence is frequently predictive of a cancer association whereas anti-MI2 is associated with the classical dermatomyositis. Two specific antibodies, anti-SRP and anti-HMGCR, are observed in patients with immune-mediated necrotizing myopathies and may be very useful to distinguish acquired myopathies from dystrophic muscular diseases in case of a slow onset and to allow the initiation of effective therapy. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Multivariate statistical process control in product quality review assessment - A case study.

PubMed

Kharbach, M; Cherrah, Y; Vander Heyden, Y; Bouklouze, A

2017-11-01

According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211.180), all finished products should be reviewed annually for the quality standards to determine the need of any change in specification or manufacturing of drug products. Conventional Statistical Process Control (SPC) evaluates the pharmaceutical production process by examining only the effect of a single factor at the time using a Shewhart's chart. It neglects to take into account the interaction between the variables. In order to overcome this issue, Multivariate Statistical Process Control (MSPC) can be used. Our case study concerns an APR assessment, where 164 historical batches containing six active ingredients, manufactured in Morocco, were collected during one year. Each batch has been checked by assaying the six active ingredients by High Performance Liquid Chromatography according to European Pharmacopoeia monographs. The data matrix was evaluated both by SPC and MSPC. The SPC indicated that all batches are under control, while the MSPC, based on Principal Component Analysis (PCA), for the data being either autoscaled or robust scaled, showed four and seven batches, respectively, out of the Hotelling T 2 95% ellipse. Also, an improvement of the capability of the process is observed without the most extreme batches. The MSPC can be used for monitoring subtle changes in the manufacturing process during an APR assessment. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

[End-of-life debate: Citizen's point of view about deep and continuous sedation].

PubMed

Toporski, J; Jonveaux-Rivasseau, T; Lamouille-Chevalier, C

2017-12-01

Sedation in palliative care meets a precise definition and corresponds to a medical practice. We assessed the comprehension of this practice by the French population. In 2015, citizen expressed their views on the Claeys-Leonetti bill by means of a consultative forum made available on the Internet site of the National Assembly. The content of the messages filed, regarding the right to deep and continuous sedation until death was analyzed using the ALCESTE textual data analysis software, supplemented by a thematic analysis in order to identify the perception that Internet users had of this practice. Among the 1819 Internet users who participated in the forum, 67 expressed their views as Health professionals, 25 of whom were directly involved in palliative care, as well as 10 sick persons. Analysis with the ALCESTE software highlighted two classes of statements. The first dealing with deep and continuous sedation, reflecting the specificity of the discourse of the Internet users. The second one consisted of textual units in which the modal verbs were dominant and overrepresented, thus providing information on the participants' perceptions. The thematic analysis highlighted four themes: death, intent, treatment and fear. Deep and continuous sedation is perceived as a euthanasic practice or raises fear of such a drift. Provision of extended and accurate information to the population and health professionals is essential to ensure that this new model of sedation is integrated into the care of the terminally ill patients and their families. Copyright © 2017 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Lipid intake in children under 3 years of age in France. A position paper by the Committee on Nutrition of the French Society of Paediatrics.

PubMed

Briend, A; Legrand, P; Bocquet, A; Girardet, J-P; Bresson, J-L; Chouraqui, J-P; Darmaun, D; Dupont, C; Frelut, M L; Goulet, O; Hankard, R; Rieu, D; Simeoni, U; Turck, D; Vidailhet, M

2014-04-01

Lipids are an important source of energy for young children and play a major role in the development and functioning of nervous tissue. Essential fatty acids and their long-chain derivatives also fulfill multiple metabolic functions and play a role in the regulation of numerous genes. The Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the French Agency for Food, Environmental and Occupational Health & Safety (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail [ANSES]) have recently recommended a minimum daily intake in preformed long-chain polyunsaturated fatty acids (LC-PUFAs): arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Mother's milk remains the only reference, but the large variability in its DHA content does not guarantee that breastfed children receive an optimal DHA intake if the mother's intake is insufficient. For children fed with infant formulas, ARA and DHA intake is often below the recommended intake because only one-third of infant formulas available on the market in France are enriched in LC-PUFAs. For all children, linoleic acid (LA) intake is on average higher than the minimal recommended values. The consequences of these differences between intake and recommended values are uncertain. A cautious attitude is to come close to the current recommendations and to advise sufficient consumption of DHA in breastfeeding women. For bottle-fed children, infant formulas enriched in LC-PUFAs and with moderate levels of LA should be preferred. LC-PUFA-rich fish should be consumed during breastfeeding, and adapted vegetable oils when complementary foods are introduced. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Short communication. Antiretroviral drug resistance among drug-naive HIV-1-infected individuals in Djibouti (Horn of Africa).

PubMed

Maslin, Jérôme; Rogier, Christophe; Caron, Melanie; Grandadam, Marc; Koeck, Jean-Louis; Nicand, Elisabeth

2005-01-01

To survey the frequency of genotypic antiretroviral resistance in drug-naive HIV-1-infected Djiboutians. A national study was conducted in the general population of Djibouti in March 2002 to determine HIV-1 seroprevalence. Blood samples were collected anonymously and plasma samples scoring positive for HIV-1 antibodies were tested for viral load. Genotypic studies were performed with viral RNA from plasma using the consensus technique of the Agence Nationale de Recherche sur le SIDA (www.hivfrenchresistance.org). Mutations were identified using the International AIDS Society-USA resistance panel and resistant virus was defined according to the ANRS algorithm. A panel of 2423 individuals representing the general population of Djibouti was included. Antibodies were detected in 53 of 2423 samples tested. The HIV-1 seroprevalence in the general population was 2.2%. Genotype C was the most prevalent, and the other isolates were CRF_02 AG, or subtype A or D. Forty-seven of the 53 samples were tested for genotypic resistance, and mutations concerning all three classes of antiretrovirals were found. The most frequent were secondary mutations associated with protease inhibitors (PIs): M36I, R41K and K20I/R. A few strains displayed primary mutations (the non-nucleoside reverse transcriptase inhibitor [NNRTI]-associated mutations K101E, K103T, L100I and G190V; the PI-associated mutation N88D; and the NRTI-associated mutation K65R). The presence of these mutations may be due to the transmission of strains from treated patients. Substantial polymorphism and a few primary mutations are found in HIV-1 non-B subtype isolates from Djiboutian antiretroviral-drug-naive individuals. This needs to be taken into account to adapt antiretroviral regimens and prophylactic schedules locally.

[Interpretation and use of routine pulmonary function tests: Spirometry, static lung volumes, lung diffusion, arterial blood gas, methacholine challenge test and 6-minute walk test].

PubMed

Bokov, P; Delclaux, C

2016-02-01

Resting pulmonary function tests (PFT) include the assessment of ventilatory capacity: spirometry (forced expiratory flows and mobilisable volumes) and static volume assessment, notably using body plethysmography. Spirometry allows the potential definition of obstructive defect, while static volume assessment allows the potential definition of restrictive defect (decrease in total lung capacity) and thoracic hyperinflation (increase in static volumes). It must be kept in mind that this evaluation is incomplete and that an assessment of ventilatory demand is often warranted, especially when facing dyspnoea: evaluation of arterial blood gas (searching for respiratory insufficiency) and measurement of the transfer coefficient of the lung, allowing with the measurement of alveolar volume to calculate the diffusing capacity of the lung for CO (DLCO: assessment of alveolar-capillary wall and capillary blood volume). All these pulmonary function tests have been the subject of an Americano-European Task force (standardisation of lung function testing) published in 2005, and translated in French in 2007. Interpretative strategies for lung function tests have been recommended, which define abnormal lung function tests using the 5th and 95th percentiles of predicted values (lower and upper limits of normal values). Thus, these recommendations need to be implemented in all pulmonary function test units. A methacholine challenge test will only be performed in the presence of an intermediate pre-test probability for asthma (diagnostic uncertainty), which is an infrequent setting. The most convenient exertional test is the 6-minute walk test that allows the assessment of walking performance, the search for arterial desaturation and the quantification of dyspnoea complaint. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

[Clinical and biological manifestations in primary parvovirus B19 infection in immunocompetent adult: a retrospective study of 26 cases].

PubMed

Parra, D; Mekki, Y; Durieu, I; Broussolle, C; Sève, P

2014-05-01

Parvovirus B19 causes erythema infectiosum in children, transient aplastic anemia in patients with hemoglobinopathies, pur red cell aplasia in immunocompromised persons and hydrops fetalis in pregnancy. The spectrum of clinical and biological manifestations in immunocompetent adult continues to grow up. We report on a case series of 26 patients with primary parvovirus B19 infection in immunocompetent adults. This is a retrospective study over the period 2000 to 2010 in two departments of internal medecine. The diagnostic was clinical, serological or molecular. There was a female predominance (sex-ratio 3.33/1). Median patient age at diagnostic was 38.8 years (range: 18-68). The predominant symptoms were fever (65%), peripheral and symmetrical polyarthralgia (62%) and skin rash (58%). Two patients had neurological manifestations (sixth cranial nerve palsy, distal paresthesia) and one patient had myocarditis. Abnormal laboratory values included increased acute phase reactants (73%), thrombocytopenia (43%), lymphopenia (38%) and elevated liver enzymes (37%). Antinuclear (19%), anti-DNA (28%) and anti-phospholipids antibodies (14%), and hypocomplementemia (32%) were observed. False reaction with anti-CMV and anti-EBV IgM positivity was documented in 27% of cases. Two patients had persistent parvovirus B19 infection. The diversity of the clinical manifestations of parvovirus B19 infection may be misleading for the clinician. However, the diagnosis should be suspected in immunocompetent adults to limit the risk of transmission to the patients who could develop a severe infection such as pregnant women or immunocompromised patients. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.