14 CFR Appendix C to Part 152 - Procurement Procedures and Requirements

Code of Federal Regulations, 2011 CFR

2011-01-01

.... The sponsor shall establish procedures for procurement of supplies, equipment, construction, and... other State, possession, or territory of the United States in the construction of a project. 3. Bid guarantee. All bids for construction or facility improvement in excess of $100,000 shall be accompanied by a...

48 CFR 28.101-2 - Solicitation provision or contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... that require a bid guarantee or similar guarantee. For example, the contracting officer may modify this... contract clause. 28.101-2 Section 28.101-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 28.101...

An economic and feasible Quantum Sealed-bid Auction protocol

NASA Astrophysics Data System (ADS)

Zhang, Rui; Shi, Run-hua; Qin, Jia-qi; Peng, Zhen-wan

2018-02-01

We present an economic and feasible Quantum Sealed-bid Auction protocol using quantum secure direct communication based on single photons in both the polarization and the spatial-mode degrees of freedom, where each single photon can carry two bits of classical information. Compared with previous protocols, our protocol has higher efficiency. In addition, we propose a secure post-confirmation mechanism without quantum entanglement to guarantee the security and the fairness of the auction.

Bidding on Railcars for Grain: A Strategic Analysis

DOT National Transportation Integrated Search

1997-05-01

Many of the U.S. railroads have introduced highly differentiated services for grain shipments in recent years, generally in the area of forward guaranteed car service. Taken together with other alternatives, these mechanisms have had the effect of es...

32 CFR 274.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Definitions. 274.2 Section 274.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.10 - Reservations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Reservations. 274.10 Section 274.10 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Definitions. 274.2 Section 274.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.10 - Reservations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Reservations. 274.10 Section 274.10 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Purpose. 274.1 Section 274.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274.1 Purpose...

32 CFR 274.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Purpose. 274.1 Section 274.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274.1 Purpose...

32 CFR 274.3 - Public notice.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Public notice. 274.3 Section 274.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.3 - Public notice.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Public notice. 274.3 Section 274.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

A False-name-Proof Double Auction Protocol for Arbitrary Evaluation Values

NASA Astrophysics Data System (ADS)

Sakurai, Yuko; Yokoo, Makoto

We develop a new false-name-proof double auction protocol called the Generalized Threshold Price Double auction (GTPD) protocol. False-name-proofness generalizes strategy-proofness by incorporating the possibility of false-name bids, e.g., bids submitted using multiple e-mail addresses. An existing protocol called TPD protocol is false-name-proof but can handle only the cases where marginal utilities of each agent always decrease, while our new GTPD protocol can handle arbitrary evaluation values. When marginal utilities can increase, some bids cannot be divided into a single unit (e.g., an all-or-nothing bid). Due to the existence of such indivisible bids, meeting supply/demand becomes difficult. Furthermore, a seller/buyer can submit a false-name-bid by pretending to be a potential buyer/seller to manipulate allocations and payments. In the GTPD protocol, the auctioneer is required to absorb the supply-demand imbalance up to a given upper-bound. Also, the GTPD incorporate a new false-name-proof one-sided auction protocol that is guaranteed to sell/buy a certain number of units. Simulation results show that when the threshold price is set appropriately, this protocol can obtain a good social surplus, and the number of absorbed units is much smaller than the given upper-bound.

32 CFR 274.4 - U.S. guaranty.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false U.S. guaranty. 274.4 Section 274.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.4 - U.S. guaranty.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false U.S. guaranty. 274.4 Section 274.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

7 CFR 3565.257 - Procurement actions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Procurement actions. 3565.257 Section 3565.257... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Property Requirements § 3565.257 Procurement actions. All construction procurement actions, whether by sealed bid or by negotiation, must be conducted in a manner that...

7 CFR 3565.257 - Procurement actions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Procurement actions. 3565.257 Section 3565.257... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Property Requirements § 3565.257 Procurement actions. All construction procurement actions, whether by sealed bid or by negotiation, must be conducted in a manner that...

32 CFR 274.9 - Delegation of authority to the Secretary of the Treasury.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Delegation of authority to the Secretary of the Treasury. 274.9 Section 274.9 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED...

32 CFR 274.9 - Delegation of authority to the Secretary of the Treasury.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Delegation of authority to the Secretary of the Treasury. 274.9 Section 274.9 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED...

Could what that ESCO sales rep said really be true? Savings realization rates in ESPC versus bid-to-spec projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coleman, Philip; Earni, Shankar; Williams, Charles

2014-08-11

Claims that savings realization is greater in energy savings performance contracts (ESPCs) are rampant at least among energy service company representatives and other ESPC cheerleaders. But hard supporting evidence for these claims has been virtually non-existent. The Department of Energy's Federal Energy Management Program uses its Compliance Tracking System (CTS) database to document the performance of federal buildings and projects towards meeting various federal energy-saving goals. This paper focuses on preliminary analysis from CTS to understand and compare the performance of federal ESPCs with projects that have been implemented with more conventional government appropriations funding. The authors have found preliminarymore » evidence using CTS that shows markedly higher savings realization rates among ESPC projects than appropriations-funded ones. There are numerous caveats to the data comparison that clamor for further study, but the difference is still intriguing. If borne out, this finding will provide concrete support to the idea that ESPCs guarantees and measurement and verification, long touted by energy service companies (ESCOs) as offering savings assurance, may truly yield substantial benefits. If ESPCs actually do perform better (i.e., have higher realization rates and savings persistence) than conventional bid-to-spec projects, the perceived premium for conducting them may look like a very good deal after all.« less

Bid purchasing of radiopharmaceuticals and radiopaque contrast media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swanson, D.P.; Jakubowski, D.L.; Shoup, L.K.

Use of product standardization and competitive-bid purchasing for radiopharmaceuticals and radiopaque contrast media in a 1000-bed teaching hospital is described. The hospital's use of radiopharmaceuticals was reviewed, and all agents were listed with their product specifications and order quantity or frequency. Manufacturers and wholesalers were asked to submit unit prices for each of their products. Similar procedures were followed for radiopaque contrast media; wholesalers and manufacturers were asked to submit unit prices that would be guaranteed for a 12-month contract period. A nuclear pharmacist and radiologists reviewed the submitted bids and awarded contracts, basing their decisions primarily on product acceptabilitymore » and selection criteria and then on relative costs of the agents. Annual costs were reduced 16% ($16,500) for radiopharmaceuticals and 21.3% ($66,500) for radiopaque contrast media. The program also resulted in decreased inventory of radiopaque contrast media and in faster and less expensive acquisition of emergency orders. Working with the radiology department to compile a standard list of radiopharmaceuticals and radiopaque contrast media and soliciting competitive bids by vendors of these products resulted in annual savings of more than $83,000.« less

22 CFR 201.25 - Bid and performance bonds and guaranties.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Bid and performance bonds and guaranties. 201... § 201.25 Bid and performance bonds and guaranties. Whenever the importer requires the posting of a bid bond or guaranty or performance bond or guaranty, the type of bond or guaranty (certified check...

Procurement of construction services: a case study on bidding competition in Singapore public sector contracts

NASA Astrophysics Data System (ADS)

Oo, B. L.; Yan, Y.

2018-04-01

There are many variables that public clients need to consider in their bidding procedure to enhance efficiency in their procurement for construction services. This paper focusses on the competitive bidding process for public sector procurement of construction services in Singapore. A distinctive feature of the Singapore government competitive bidding process is that full bidding feedback information is released to all competing bidders (and public). The specific objectives are: (i) to examine the degree of competition in the construction markets; and (ii) to examine the bidding performance of competing bidders. Based on a collection of bidding data for a 15-month period, the results show the market environment of the Singapore public sector construction contracting is highly competitive with long bidder lists. In selection of contractors, only 50% of the contracts were awarded to lowest bidders. The results also show that the competing contractors can be broadly classified into three groups based on their bidding performance in terms of number of bidding attempts, bidding success rate and bidding competitiveness. These results provide a useful insight into the bidding competition in the Singapore public sector construction contracting, especially to new market entrants and foreign contractors who want to bid for jobs in Singapore.

Anonymous, Yet Trustworthy Auctions

NASA Astrophysics Data System (ADS)

Chanda, Prasit Bikash; Naessens, Vincent; de Decker, Bart

An auction is an inevitable market mechanism to setup prices of goods or services in a competitive and dynamic environment. Anonymity of bidders is required to conceal their business strategies from competitors. However, it is also essential to provide the seller guarantees that a bidder is trustworthy and competent enough to perform certain tasks (e.g transports). This paper proposes an auction protocol where bidders will participate anonymously, yet prove to be trustworthy and competent and can be held accountable towards auctioneers and sellers. Moreover, the protocol introduces promises, bonuses and compensations to ensure the best price for the sellers, extra profit for bidders and opportunities for newcomers in the business. It also handles ties, and copes with last minute bidding. Finally, the auction’s fair proceedings and outcome can be verified by everyone.

46 CFR Sec. 2 - Description of NSA-WORKSMALREP Contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... competitive bids, spot bids, or by negotiation for the performance of ship repair work. NSA Order No. 46 (SRM... bids, spot bids or negotiation, therefore, further reference thereto will not be made herein. ...

Cost containment through pharmaceutical procurement: a Caribbean case study.

PubMed

Huff-Rousselle, M; Burnett, F

1996-01-01

This article discusses the potential for health sector cost containment in developing countries through improved pharmaceutical procurement. By describing the specific example of the Eastern Caribbean Drug Service (ECDS), which provides a pooled procurement service to nine ministries of health in the small island nations of the Caribbean, it examines the elements of the procurement operation that allowed ECDS to reduce unit costs for pharmaceuticals by over 50 per cent during its first procurement cycle. The analysis of ECDS considers: (1) political will, institutional alliances, and the creation of a public sector monopsony; (2) pooling demand; (3) restricted international tendering and the pharmaceutical industry; (4) estimating demand and supplier guarantees; (5) reducing variety and increasing volume through standardizing pack sizes, dosage forms and strengths; (6) generic bidding and therapeutic alternative bidding; (7) mode of transport from foreign suppliers; (8) financing mechanisms, including choice of currency, foreign exchange, and terms of payment; (9) market conditions and crafting and enforcing supplier contracts; and, (10) the adjudication process, including consideration of suppliers' past performance, precision requirements in the manufacturing process, number of products awarded to suppliers, and issues of judgment. The authors consider the relevance of this agency's experience to other developing countries by providing a blueprint that can be adopted or modified to suit other situations.

Dynamic imaging of interaction between protein 14-3-3 and Bid in living cells

NASA Astrophysics Data System (ADS)

Chen, Tongsheng; Xing, Da; Wang, Jinjun

2006-02-01

The 14-3-3 proteins are known to sequester certain pro-apoptotic members of this family. BH3- interacting domain death agonist (Bid) may contribute to tumor necrosis factor α(TNF-α)-induced neuronal death, although regulation by 14-3-3 has not been reported. In this study we examined whether 14-3-3 proteins interact with Bid/tBid during TNF-α-induced cell death. The TNF-αtriggered Bid cleavage and tBid translocated to mitochondria. Human lung adenocarcinoma cells were co-transfected with both CFP-Bid and 14-3-3-YFP plasmids, and the dynamical interaction between the Bid/tBid and 14-3-3 were performed on laser confocal fluorescence microscope in single living cell during TNF-α-induced cell apoptosis. The Bid distribute equally only in the cytoplasm of healthy cells, and the 14-3-3 protein distribute not only in the cytoplasm but also in the nucleus of healthy cells. Our data showed that the tBid aggregate, but the 14-3-3 protein does not aggregate as the tBid, and the 14-3-3 protein separate from the aggregated tBid, implying that the 14-3-3 proteins do not interact with the aggregated tBid after TNF-αtreatment.

Body Image Disturbance in 1000 Male Appearance and Performance Enhancing Drug Users

PubMed Central

Hildebrandt, Tom; Alfano, Lauren; Langenbucher, James W.

2010-01-01

Body image disturbance (BID) among men has only recently become a phenomenon of clinical significance with noted heterogeneity in the behavioral consequences of these disturbances. The degree of heterogeneity among appearance and performance enhancing drug (APED) users is unknown and an empirically derived framework for studying BID is necessary. 1000 APED users were recruited via the Internet and they completed a comprehensive online assessment APED use patterns, motivations, consequences, and BID. Data were evaluated using latent trait, latent class, and factor mixture models. Model results were validated using a range of covariates including cycle characteristics, age, APED history, and APED risk. A 1-Factor, 4-Class model provided the best fit to the data with Class 1 scoring the highest on all measures of BID and Class 4 the lowest on all measures. Class 2 differed in their preference for being lean over muscular and Class 3 preferred adding mass and size. Each class was associated with unique risks, APED history, and training identity. Not all APED users suffer from significant BID and there are unique profiles for those with elevated BID. Future research on male BID should account for this structure in order to better define relevant diagnostic categories and evaluate the clinical significance of BID. PMID:20110092

Solve the organ shortage: let the bidding begin!

PubMed

Kevorkian, J

2001-01-01

Commercialization of transplantable human organs is the only sure way to end the crisis of their supply. This is best accomplished by implementing a free, non-profit, nationwide, ultimately global online auction market. It should be independent of the current United Network of Organ Sharing (UNOS) system dealing solely with altruistic donation, and of governmental, sectarian, academic, and other bureaucratic control. The operation of such an auction is described with a hypothetical example. An included provision guarantees equity for poor, uninsured, and indigent recipients. Money accrued can be substantial, and would be disbursed by established formula, with major portions going to donors' families and to special funds to be used to bid for the poor and to defray costs incurred by them. As the organ shortage eases, bid prices should drop, resulting perhaps in eventual altruistic donation. Objections to commericalization based on ethics, bodily sanctity, inequity, pecuniary greed, and the slippery slope tocsin are nullified by cogent arguments and examples. The current situation has worsened despite so-called required request laws, proposed token payments to cover funeral expenses for donor families, and extensive media advertising to spur altruistic donation. Prohibitive national and state laws must be rescinded for the sake of more than 60,000 patients now on lengthening waiting lists. A profession committed to saving lives is duty-bound to endorse, help implement, and participate in an auction system dedicated to that end.

An Assessment of the Armed Forces of the Philippines Modernization Program

DTIC Science & Technology

2007-12-14

Sayaff Group BAC Bids and Awards Committee BCDA Bases Conversion and Development Authority BEP Bid Evaluation Plan BIR Bureau of Internal Revenue...contractor execute the requirements of the contract with regard to cost, schedule and performance (Sammet and Green 1990, 136) Bid Evaluation Plan or BEP is...adopted in the evaluation and assessment of bidders’ statements and the method and criteria for the evaluation and assessment of bids. The BEP also

23 CFR 635.110 - Licensing and qualification of contractors.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.110 Licensing and qualification... licensing contractors, who may bid for, be awarded, or perform Federal-aid highway contracts, shall be... of a bid or before the bid may be considered for award of a contract. This, however, is not intended...

Preliminary Study on Bidding Price Ratio Pattern of Public Works in Taiwan - a Case Study of Bridges, Elevated Highways, Tunnels and Subways

NASA Astrophysics Data System (ADS)

Tseng, Paoshan; Wang, Hanhsiang; Chen, Pingfu; Yeh, Lihsu

2018-01-01

Commonly seen tender bid price information of the public works in Taiwan are the budget amount, floor price, awarding price and so on. The ratio of the awarding price to the floor price or budget price is the so-called bidding price ratio. This ratio is influenced by multifaceted factor interactions and is significant to decision making management in engineering projects. Low bidding price ratio may imply that the budget allocation by the tendering agency is inconsiderate or due to the improper market competition of low price bid rigging. High bidding price ratio in turn may indicate that the allocated budget is relatively low, bidder risks in increased contract execution uncertainty or even exclusive bidding scenario. Therefore, the correlation between the bidding price ratio and the aforementioned tender award information is the key issue of this study. This study gathered the tender information of the civil engineering projects in Taiwan within the past seven years. By performing statistical analysis and clustering the gathered data by bidding price ratio, this study investigated the influencing factors and regulations of bidding price ratio using data mining approach.

Automated Demand Response for Energy Sustainability

DTIC Science & Technology

2015-05-01

project’s stated performance objectives. Emerging opportunities to participate in wholesale electricity markets can provide important economic, energy, and...Response in Wholesale Electricity Markets ..................................................... 7 Figure 5. Demand Bidding Communication and Control...resource in response to market or reliability conditions Demand Bidding Program DR programs that encourage customers to bid into an electricity market

Landsat bill passes in Congress

NASA Astrophysics Data System (ADS)

Richman, Barbara T.

1984-04-01

Commercialization of the land remote-sensing system is virtually guaranteed with the successful completion last week of an informal conference on the differences in the House of Representatives and Senate versions of the Land Remote Sensing Commercialization Act (H.R. 5155). Moreover, the House ratified the compromise version on June 28; the Senate was expected to ratify the bill before the July 4 recess. The bill will then be sent to President Ronald Reagan for his signature. Also on June 28, the Secretary of Commerce announced his selection for final contract negotiations of two of the seven bids received this spring for the operation of Landsat.

A market-based optimization approach to sensor and resource management

NASA Astrophysics Data System (ADS)

Schrage, Dan; Farnham, Christopher; Gonsalves, Paul G.

2006-05-01

Dynamic resource allocation for sensor management is a problem that demands solutions beyond traditional approaches to optimization. Market-based optimization applies solutions from economic theory, particularly game theory, to the resource allocation problem by creating an artificial market for sensor information and computational resources. Intelligent agents are the buyers and sellers in this market, and they represent all the elements of the sensor network, from sensors to sensor platforms to computational resources. These agents interact based on a negotiation mechanism that determines their bidding strategies. This negotiation mechanism and the agents' bidding strategies are based on game theory, and they are designed so that the aggregate result of the multi-agent negotiation process is a market in competitive equilibrium, which guarantees an optimal allocation of resources throughout the sensor network. This paper makes two contributions to the field of market-based optimization: First, we develop a market protocol to handle heterogeneous goods in a dynamic setting. Second, we develop arbitrage agents to improve the efficiency in the market in light of its dynamic nature.

Evaluation of a novel helium ionization detector within the context of (low-)flow modulation comprehensive two-dimensional gas chromatography.

PubMed

Franchina, Flavio A; Maimone, Mariarosa; Sciarrone, Danilo; Purcaro, Giorgia; Tranchida, Peter Q; Mondello, Luigi

2015-07-10

The present research is focused on the use and evaluation of a novel helium ionization detector, defined as barrier discharge ionization detector (BID), within the context of (low-)flow modulation comprehensive two-dimensional gas chromatography (FM GC×GC). The performance of the BID device was compared to that of a flame ionization detector (FID), under similar FM GC×GC conditions. Following development and optimization of the FM GC×GC method, the BID was subjected to fine tuning in relation to acquisition frequency and discharge flow. Moreover, the BID performance was measured and compared to that of the FID, in terms of extra-column band broadening, sensitivity and dynamic range. The comparative study was carried out by using standard compounds belonging to different chemical classes, along with a sample of diesel fuel. Advantages and disadvantages of the BID system, also within the context of FM GC×GC, are critically discussed. In general, the BID system was characterized by a more limited dynamic range and increased sensitivity, compared to the FID. Additionally, BID and FID contribution to band broadening was found to be similar under the operational conditions applied. Particular attention was devoted to the behaviour of the FM GC×GC-BID system toward saturated and aromatic hydrocarbons, for a possible future use in the field of mineral-oil food contamination research. Copyright © 2015 Elsevier B.V. All rights reserved.

76 FR 47226 - Notice of HUD-Held Multifamily Loan Sale (MLS 2011-2)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

... (BIP) was made available online to qualified bidders on June 29, 2011. Submission of bids for the loans...-performing mortgage loans. A final listing of the Mortgage Loans was included in the BIP. The Mortgage Loans... 2011-2. The Bidding Process The BIP described in detail the procedure for bidding in MLS 2011- 2. The...

A comparison of pay-as-bid and marginal pricing in electricity markets

NASA Astrophysics Data System (ADS)

Ren, Yongjun

This thesis investigates the behaviour of electricity markets under marginal and pay-as-bid pricing. Marginal pricing is believed to yield the maximum social welfare and is currently implemented by most electricity markets. However, in view of recent electricity market failures, pay-as-bid has been extensively discussed as a possible alternative to marginal pricing. In this research, marginal and pay-as-bid pricing have been analyzed in electricity markets with both perfect and imperfect competition. The perfect competition case is studied under both exact and uncertain system marginal cost prediction. The comparison of the two pricing methods is conducted through two steps: (i) identify the best offer strategy of the generating companies (gencos); (ii) analyze the market performance under these optimum genco strategies. The analysis results together with numerical simulations show that pay-as-bid and marginal pricing are equivalent in a perfect market with exact system marginal cost prediction. In perfect markets with uncertain demand prediction, the two pricing methods are also equivalent but in an expected value sense. If we compare from the perspective of second order statistics, all market performance measures exhibit much lower values under pay-as-bid than under marginal pricing. The risk of deviating from the mean is therefore much higher under marginal pricing than under pay-as-bid. In an imperfect competition market with exact demand prediction, the research shows that pay-as-bid pricing yields lower consumer payments and lower genco profits. This research provides quantitative evidence that challenges some common claims about pay-as-bid pricing. One is that under pay-as-bid, participants would soon learn how to offer so as to obtain the same or higher profits than what they would have obtained under marginal pricing. This research however shows that, under pay-as-bid, participants can at best earn the same profit or expected profit as under marginal pricing. A second common claim refuted by this research is that pay-as-bid does not provide correct price signals if there is a scarcity of generation resources. We show that pay-as-bid does provide a price signal with such characteristics and furthermore argue that the price signal under marginal pricing with gaming may not necessarily be correct since it would then not reflect a lack of generation capacity but a desire to increase profit.

Notification: Hotline Complaint – Region 7 Compliance with Bid, Payment, and Performance Bond Requirements Outlined in Federal Acquisition Regulation (FAR) Part 28

EPA Pesticide Factsheets

June 1, 2012. In response to an anonymous hotline complaint, the OIG plans to conduct a review of Region 7’s compliance with bid, payment, and performance bond requirements outlined in Federal Acquisition Regulation (FAR) Part 28.

BIDS apps: Improving ease of use, accessibility, and reproducibility of neuroimaging data analysis methods

PubMed Central

Auer, Tibor; Churchill, Nathan W.; Flandin, Guillaume; Guntupalli, J. Swaroop; Raffelt, David; Quirion, Pierre-Olivier; Smith, Robert E.; Strother, Stephen C.; Varoquaux, Gaël

2017-01-01

The rate of progress in human neurosciences is limited by the inability to easily apply a wide range of analysis methods to the plethora of different datasets acquired in labs around the world. In this work, we introduce a framework for creating, testing, versioning and archiving portable applications for analyzing neuroimaging data organized and described in compliance with the Brain Imaging Data Structure (BIDS). The portability of these applications (BIDS Apps) is achieved by using container technologies that encapsulate all binary and other dependencies in one convenient package. BIDS Apps run on all three major operating systems with no need for complex setup and configuration and thanks to the comprehensiveness of the BIDS standard they require little manual user input. Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems. BIDS Apps overcome this limitation by taking advantage of the Singularity container technology. As a proof of concept, this work is accompanied by 22 ready to use BIDS Apps, packaging a diverse set of commonly used neuroimaging algorithms. PMID:28278228

Pricing strategies, the strength of bidding intentions, and online auction performance: a cross-cultural study.

PubMed

Peng, Yu-Shu; Jan, Lih-Tsyr

2009-10-01

Over the past decade, electronic markets based on the Internet, particularly online auctions, have become popular venues for conducting business. Previous studies often focused on the construction of the best bidding model, while few studies have tried to integrate multiple pricing strategies to predict the probability of closing an auction and the price premium. This study constructs a mediated model to examine the relationship among pricing strategies, the strength of bidding intentions, and online auction performance. The sample consists of 1,055 auctions of iPod MP3 players from eBay Web sites in Hong Kong, Singapore, Belgium, and France. Empirical results show that the pricing strategies directly influence both the probability of closing an auction and the level of price premium. The pricing strategies also indirectly influence the price premium through the mediating effect of the strength of bidding intentions.

Europe looks to wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gipe, P.

1989-09-01

The European Economic Community (EEC) sees a guaranteed market for 4,000 MW of wind energy through the year 2000, according to Komninos Diamantaras, wind program manager for the EEC in Brussels. Diamantaras says the European political climate for wind energy has changed for the better because of increased attention to air pollution's effect on global weather. He added that during the past year several common market members have announced plans to develop substantial amounts of wind energy. The United Kingdom, Denmark and the Netherlands have each stated their intent to build 1,000 MW of wind generation by the turn ofmore » the century, and Italy recently announced plans to add from 300-600 MW. Germany has also made plans to promote wind generation. The decision to include firms from non-EEC countries is left to the utility. Whether a U.S. firm will be permitted to bid on a EEC-member tender may be determined by its relation to European manufacturers. Regardless of the EEC's policy towards U.S. firms, member states may still exclude bidding by foreign firms for state subsidized projects when they are experimental. Just what is meant by experimental is has yet to be determined.« less

A Technique for Evaluating Vendor Bids for Stock Replenishment of a Consumable Item.

DTIC Science & Technology

1985-06-01

RD-A159 957 A TECHNIQUE FOR EVALUATING VENDOR BIDS FOR STOCK 1/1 REPLENISHMENT OF A CONSUMABLE I TEM(U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA J...REPORT II PER106 COVERED *A Technique for Evaluating Vendor Bids Juner’ 1985 i for Stock Replenishment of a Consumable tern 6. PERFORMING ORG. REPORT...Control Center (SPCC) Uniform Inventory Control Program (UICP) wholesale replenishment model for 1H cognizance symbol ( consumable ) material is an order

48 CFR 36.213-3 - Invitations for bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... bidders to inspect the site, obtain subcontract bids, examine data concerning the work, and prepare... examine the data concerning performance of the work (see 36.210). (6) Information concerning any facilities, such as utilities, office space, and warehouse space, to be furnished during construction. (7...

48 CFR 36.213-3 - Invitations for bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... bidders to inspect the site, obtain subcontract bids, examine data concerning the work, and prepare... examine the data concerning performance of the work (see 36.210). (6) Information concerning any facilities, such as utilities, office space, and warehouse space, to be furnished during construction. (7...

Truthful Incentive Mechanisms for Social Cost Minimization in Mobile Crowdsourcing Systems

PubMed Central

Duan, Zhuojun; Yan, Mingyuan; Cai, Zhipeng; Wang, Xiaoming; Han, Meng; Li, Yingshu

2016-01-01

With the emergence of new technologies, mobile devices are capable of undertaking computational and sensing tasks. A large number of users with these mobile devices promote the formation of the Mobile Crowdsourcing Systems (MCSs). Within a MCS, each mobile device can contribute to the crowdsourcing platform and get rewards from it. In order to achieve better performance, it is important to design a mechanism that can attract enough participants with mobile devices and then allocate the tasks among participants efficiently. In this paper, we are interested in the investigation of tasks allocation and price determination in MCSs. Two truthful auction mechanisms are proposed for different working patterns. A Vickrey–Clarke–Groves (VCG)-based auction mechanism is proposed to the continuous working pattern, and a suboptimal auction mechanism is introduced for the discontinuous working pattern. Further analysis shows that the proposed mechanisms have the properties of individual rationality and computational efficiencies. Experimental results suggest that both mechanisms guarantee all the mobile users bidding with their truthful values and the optimal maximal social cost can be achieved in the VCG-based auction mechanism. PMID:27058541

Regulation of Programmed Necrosis and Bone Marrow Failure

DTIC Science & Technology

2017-03-01

length levels of another Caspase-8 substrate, Cylindromatosis (CYLD), was also observed (Fig. S3G). Furthermore, deletion of Caspase-8 using CRISPR ...down of Caspase-8 utilizing the CRISPR -Cas9 system in Bid +/+ cells. Experiment was performed two times. (I) Diagram of potential role for Bid in the

Decentralized Control of Scheduling in Distributed Systems.

DTIC Science & Technology

1983-12-15

does not perform quite as well as the 10 state system, but is less sensitive to changes in scheduling period. It performs best when scheduling is...intra-process concerns. We extend theLr concept of a process to inolude Inter -ress comunication. That is. various form of send and receive primitives...Current busyness of each site based on some responses to requests for bids. A received bid is utilization factor. adjusted by incrementing it by a

Group search optimiser-based optimal bidding strategies with no Karush-Kuhn-Tucker optimality conditions

NASA Astrophysics Data System (ADS)

Yadav, Naresh Kumar; Kumar, Mukesh; Gupta, S. K.

2017-03-01

General strategic bidding procedure has been formulated in the literature as a bi-level searching problem, in which the offer curve tends to minimise the market clearing function and to maximise the profit. Computationally, this is complex and hence, the researchers have adopted Karush-Kuhn-Tucker (KKT) optimality conditions to transform the model into a single-level maximisation problem. However, the profit maximisation problem with KKT optimality conditions poses great challenge to the classical optimisation algorithms. The problem has become more complex after the inclusion of transmission constraints. This paper simplifies the profit maximisation problem as a minimisation function, in which the transmission constraints, the operating limits and the ISO market clearing functions are considered with no KKT optimality conditions. The derived function is solved using group search optimiser (GSO), a robust population-based optimisation algorithm. Experimental investigation is carried out on IEEE 14 as well as IEEE 30 bus systems and the performance is compared against differential evolution-based strategic bidding, genetic algorithm-based strategic bidding and particle swarm optimisation-based strategic bidding methods. The simulation results demonstrate that the obtained profit maximisation through GSO-based bidding strategies is higher than the other three methods.

50 CFR 600.1107 - Southeast Alaska Purse Seine Salmon Fishery capacity reduction program, including fee payment and...

Code of Federal Regulations, 2012 CFR

2012-10-01

... examine each submitted Bid for consistency and the necessary elements, including the validity of the... finite. The failure of a Permit Holder, whose bid was accepted, to perform the obligations under the... submitted by the bidder and the SRA is an integral element of the Reduction Plan. Now, therefore, for good...

50 CFR 600.1107 - Southeast Alaska Purse Seine Salmon Fishery capacity reduction program, including fee payment and...

Code of Federal Regulations, 2013 CFR

2013-10-01

... examine each submitted Bid for consistency and the necessary elements, including the validity of the... finite. The failure of a Permit Holder, whose bid was accepted, to perform the obligations under the... submitted by the bidder and the SRA is an integral element of the Reduction Plan. Now, therefore, for good...

50 CFR 600.1107 - Southeast Alaska Purse Seine Salmon Fishery capacity reduction program, including fee payment and...

Code of Federal Regulations, 2014 CFR

2014-10-01

... examine each submitted Bid for consistency and the necessary elements, including the validity of the... finite. The failure of a Permit Holder, whose bid was accepted, to perform the obligations under the... submitted by the bidder and the SRA is an integral element of the Reduction Plan. Now, therefore, for good...

Coadministration of lorcaserin and phentermine for weight management: A 12‐week, randomized, pilot safety study

PubMed Central

Garvey, W. Timothy; Greenway, Frank L.; Zhou, Sharon; Fain, Randi; Pilson, Robert; Fujioka, Ken; Aronne, Louis J.

2017-01-01

Objective To assess the short‐term tolerability of lorcaserin alone or with two dose regimens of phentermine. Methods This was a 12‐week, randomized, double‐blind, pilot safety study of N = 238 nondiabetic patients with obesity or overweight with ≥1 comorbidity randomized to lorcaserin 10 mg twice daily (BID; LOR BID) alone or with phentermine 15 mg once daily (QD; LOR BID+PHEN QD) or 15 mg twice daily (LOR BID+PHEN BID). Patients reporting ≥ 1 of 9 potentially serotonergic adverse events (AEs), mean weight loss (WL), and ≥5% WL are reported. Results N = 238 were randomized, and N = 235 were treated. N = 94 reported potentially serotonergic AEs: 37.2% LOR BID, 42.3% LOR BID+PHEN QD, and 40.5% LOR BID+PHEN BID. AEs leading to discontinuation were reported approximately twice as often in the LOR BID+PHEN BID group versus the LOR BID group. Mean WL was 3.5 kg/3.3%, 7.0 kg/6.7%, and 7.6 kg/7.2% for LOR BID, LOR BID+PHEN QD, and LOR BID+PHEN BID, respectively. At least 5% WL was achieved by 28.2% LOR BID, 59.0% LOR BID+PHEN QD (P = 0.0002 vs. LOR BID), and 70.9% LOR BID+PHEN BID (P < 0.0001 vs. LOR BID) patients. Conclusions Phentermine added to lorcaserin enhanced short‐term weight loss but did not increase incidence of potentially serotonergic AEs; however, phentermine twice daily increased discontinuation compared to both lorcaserin alone and lorcaserin plus phentermine once daily. PMID:28440045

Coadministration of lorcaserin and phentermine for weight management: A 12-week, randomized, pilot safety study.

PubMed

Smith, Steven R; Garvey, W Timothy; Greenway, Frank L; Zhou, Sharon; Fain, Randi; Pilson, Robert; Fujioka, Ken; Aronne, Louis J

2017-05-01

To assess the short-term tolerability of lorcaserin alone or with two dose regimens of phentermine. This was a 12-week, randomized, double-blind, pilot safety study of N = 238 nondiabetic patients with obesity or overweight with ≥1 comorbidity randomized to lorcaserin 10 mg twice daily (BID; LOR BID) alone or with phentermine 15 mg once daily (QD; LOR BID+PHEN QD) or 15 mg twice daily (LOR BID+PHEN BID). Patients reporting ≥ 1 of 9 potentially serotonergic adverse events (AEs), mean weight loss (WL), and ≥5% WL are reported. N = 238 were randomized, and N = 235 were treated. N = 94 reported potentially serotonergic AEs: 37.2% LOR BID, 42.3% LOR BID+PHEN QD, and 40.5% LOR BID+PHEN BID. AEs leading to discontinuation were reported approximately twice as often in the LOR BID+PHEN BID group versus the LOR BID group. Mean WL was 3.5 kg/3.3%, 7.0 kg/6.7%, and 7.6 kg/7.2% for LOR BID, LOR BID+PHEN QD, and LOR BID+PHEN BID, respectively. At least 5% WL was achieved by 28.2% LOR BID, 59.0% LOR BID+PHEN QD (P = 0.0002 vs. LOR BID), and 70.9% LOR BID+PHEN BID (P < 0.0001 vs. LOR BID) patients. Phentermine added to lorcaserin enhanced short-term weight loss but did not increase incidence of potentially serotonergic AEs; however, phentermine twice daily increased discontinuation compared to both lorcaserin alone and lorcaserin plus phentermine once daily. © 2017 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS).

Input-Guarantee Versus Performance-Guarantee Approaches to School Accountability: Cross-State Comparisons of Policies, Resources, and Outcomes

ERIC Educational Resources Information Center

Lee, Jaekyung

2006-01-01

States' policy approaches to accountability tend to divide between a primary emphasis on input guarantees and a primary emphasis on performance guarantees. In the midst of keen controversies about the impact of high-stakes testing under the No Child Left Behind Act, this article examines separate and joint effects of input-guarantee versus…

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis*

PubMed Central

Huang, Kai; Zhang, Jingjing; O'Neill, Katelyn L.; Gurumurthy, Channabasavaiah B.; Quadros, Rolen M.; Tu, Yaping; Luo, Xu

2016-01-01

The BH3-only protein Bid is known as a critical mediator of the mitochondrial pathway of apoptosis following death receptor activation. However, since full-length Bid possesses potent apoptotic activity, the role of a caspase-mediated Bid cleavage is not established in vivo. In addition, due to the fact that multiple caspases cleave Bid at the same site in vitro, the identity of the Bid-cleaving caspase during death receptor signaling remains uncertain. Moreover, as Bid maintains its overall structure following its cleavage by caspase 8, it remains unclear how Bid is activated upon cleavage. Here, Bid-deficient (Bid KO) colon cancer cells were generated by gene editing, and were reconstituted with wild-type or mutants of Bid. While the loss of Bid blocked apoptosis following treatment by TNF-related apoptosis inducing ligand (TRAIL), this blockade was relieved by re-introduction of the wild-type Bid. In contrast, the caspase-resistant mutant BidD60E and a BH3 defective mutant BidG94E failed to restore TRAIL-induced apoptosis. By generating Bid/Bax/Bak-deficient (TKO) cells, we demonstrated that Bid is primarily cleaved by caspase 8, not by effector caspases, to give rise to truncated Bid (tBid) upon TRAIL treatment. Importantly, despite the presence of an intact BH3 domain, a tBid mutant lacking the mitochondrial targeting helices (α6 and α7) showed diminished apoptotic activity. Together, these results for the first time establish that cleavage by caspase 8 and the subsequent association with the outer mitochondrial membrane are two critical events that activate Bid during death receptor-mediated apoptosis. PMID:27053107

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis.

PubMed

Huang, Kai; Zhang, Jingjing; O'Neill, Katelyn L; Gurumurthy, Channabasavaiah B; Quadros, Rolen M; Tu, Yaping; Luo, Xu

2016-05-27

The BH3-only protein Bid is known as a critical mediator of the mitochondrial pathway of apoptosis following death receptor activation. However, since full-length Bid possesses potent apoptotic activity, the role of a caspase-mediated Bid cleavage is not established in vivo In addition, due to the fact that multiple caspases cleave Bid at the same site in vitro, the identity of the Bid-cleaving caspase during death receptor signaling remains uncertain. Moreover, as Bid maintains its overall structure following its cleavage by caspase 8, it remains unclear how Bid is activated upon cleavage. Here, Bid-deficient (Bid KO) colon cancer cells were generated by gene editing, and were reconstituted with wild-type or mutants of Bid. While the loss of Bid blocked apoptosis following treatment by TNF-related apoptosis inducing ligand (TRAIL), this blockade was relieved by re-introduction of the wild-type Bid. In contrast, the caspase-resistant mutant Bid(D60E) and a BH3 defective mutant Bid(G94E) failed to restore TRAIL-induced apoptosis. By generating Bid/Bax/Bak-deficient (TKO) cells, we demonstrated that Bid is primarily cleaved by caspase 8, not by effector caspases, to give rise to truncated Bid (tBid) upon TRAIL treatment. Importantly, despite the presence of an intact BH3 domain, a tBid mutant lacking the mitochondrial targeting helices (α6 and α7) showed diminished apoptotic activity. Together, these results for the first time establish that cleavage by caspase 8 and the subsequent association with the outer mitochondrial membrane are two critical events that activate Bid during death receptor-mediated apoptosis. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Preventing conflicts among bid curves used with transactive controllers in a market-based resource allocation system

DOEpatents

Fuller, Jason C.; Chassin, David P.; Pratt, Robert G.; Hauer, Matthew; Tuffner, Francis K.

2017-03-07

Disclosed herein are representative embodiments of methods, apparatus, and systems for distributing a resource (such as electricity) using a resource allocation system. One of the disclosed embodiments is a method for operating a transactive thermostatic controller configured to submit bids to a market-based resource allocation system. According to the exemplary method, a first bid curve is determined, the first bid curve indicating a first set of bid prices for corresponding temperatures and being associated with a cooling mode of operation for a heating and cooling system. A second bid curve is also determined, the second bid curve indicating a second set of bid prices for corresponding temperatures and being associated with a heating mode of operation for a heating and cooling system. In this embodiment, the first bid curve, the second bid curve, or both the first bid curve and the second bid curve are modified to prevent overlap of any portion of the first bid curve and the second bid curve.

7 CFR 2201.25 - Performance Agreement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Performance Agreement. 2201.25 Section 2201.25... LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.25 Performance Agreement. (a) The Borrower of a Loan guaranteed under the Program shall enter into a Performance Agreement...

7 CFR 2201.25 - Performance Agreement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Performance Agreement. 2201.25 Section 2201.25... LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.25 Performance Agreement. (a) The Borrower of a Loan guaranteed under the Program shall enter into a Performance Agreement...

7 CFR 2201.25 - Performance Agreement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Performance Agreement. 2201.25 Section 2201.25... LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.25 Performance Agreement. (a) The Borrower of a Loan guaranteed under the Program shall enter into a Performance Agreement...

23 CFR 635.113 - Bid opening and bid tabulations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.113 Bid opening and bid tabulations. (a) All bids... contractors, during the period following the opening of bids and before the award of the contract shall not be...

Optimal GENCO bidding strategy

NASA Astrophysics Data System (ADS)

Gao, Feng

Electricity industries worldwide are undergoing a period of profound upheaval. The conventional vertically integrated mechanism is being replaced by a competitive market environment. Generation companies have incentives to apply novel technologies to lower production costs, for example: Combined Cycle units. Economic dispatch with Combined Cycle units becomes a non-convex optimization problem, which is difficult if not impossible to solve by conventional methods. Several techniques are proposed here: Mixed Integer Linear Programming, a hybrid method, as well as Evolutionary Algorithms. Evolutionary Algorithms share a common mechanism, stochastic searching per generation. The stochastic property makes evolutionary algorithms robust and adaptive enough to solve a non-convex optimization problem. This research implements GA, EP, and PS algorithms for economic dispatch with Combined Cycle units, and makes a comparison with classical Mixed Integer Linear Programming. The electricity market equilibrium model not only helps Independent System Operator/Regulator analyze market performance and market power, but also provides Market Participants the ability to build optimal bidding strategies based on Microeconomics analysis. Supply Function Equilibrium (SFE) is attractive compared to traditional models. This research identifies a proper SFE model, which can be applied to a multiple period situation. The equilibrium condition using discrete time optimal control is then developed for fuel resource constraints. Finally, the research discusses the issues of multiple equilibria and mixed strategies, which are caused by the transmission network. Additionally, an advantage of the proposed model for merchant transmission planning is discussed. A market simulator is a valuable training and evaluation tool to assist sellers, buyers, and regulators to understand market performance and make better decisions. A traditional optimization model may not be enough to consider the distributed, large-scale, and complex energy market. This research compares the performance and searching paths of different artificial life techniques such as Genetic Algorithm (GA), Evolutionary Programming (EP), and Particle Swarm (PS), and look for a proper method to emulate Generation Companies' (GENCOs) bidding strategies. After deregulation, GENCOs face risk and uncertainty associated with the fast-changing market environment. A profit-based bidding decision support system is critical for GENCOs to keep a competitive position in the new environment. Most past research do not pay special attention to the piecewise staircase characteristic of generator offer curves. This research proposes an optimal bidding strategy based on Parametric Linear Programming. The proposed algorithm is able to handle actual piecewise staircase energy offer curves. The proposed method is then extended to incorporate incomplete information based on Decision Analysis. Finally, the author develops an optimal bidding tool (GenBidding) and applies it to the RTS96 test system.

Rivastigmine: a placebo controlled trial of twice daily and three times daily regimens in patients with Alzheimer's disease.

PubMed

Feldman, Howard H; Lane, Roger

2007-10-01

To evaluate the efficacy and safety of rapidly titrated rivastigmine administered twice (BID) or three times (TID) daily in patients with mild to moderate Alzheimer's disease (AD). This was a 26 week international, randomised, double blind, placebo controlled study in which 678 patients with probable AD received placebo or rivastigmine 2-12 mg/day BID or TID. Primary outcome measures included the cognitive subscale of the AD Assessment Scale (ADAS-cog) and categorical analysis of the Clinician Interview Based Impression of Change incorporating caregiver information (CIBIC-Plus). Secondary outcomes were the CIBIC-Plus change from baseline, Progressive Deterioration Scale, ADAS-cogA, Mini-Mental State Examination and Global Deterioration Scale. At week 26, mean rivastigmine dose was 9.6 (2.76) mg/day in the TID group and 8.9 (2.93) mg/day in the BID group. Mean ADAS-cog changes from baseline in the TID and BID rivastigmine treated groups were -0.2 (SD 7.3) and 1.2 (SD 7.2) versus 2.8 (SD 7.2) for the placebo group (p<0.05). Differences between rivastigmine TID and placebo on the CIBIC-Plus categorical responder analysis were significant (31% vs 19%; p<0.05, intention to treat). No significant differences were seen between BID and placebo for this outcome measure. Adverse events were predominantly gastrointestinal, occurring mainly during dose titration. Withdrawal because of adverse events accounted for 17% of BID, 11% of TID and 9% of placebo patients. Rivastigmine administered as a BID or TID regimen significantly benefited cognitive, function and global performances in AD patients. The TID regimen showed a tendency for superior tolerability and permitted titration to higher doses, an outcome that is significant as the efficacy of rivastigmine is dose related.

42 CFR 423.286 - Rules regarding premiums.

Code of Federal Regulations, 2011 CFR

2011-10-01

... section for the difference between the bid and the national average monthly bid amount, any supplemental... percentage as specified in paragraph (b) of this section; and (2) National average monthly bid amount... reflect difference between bid and national average bid. If the amount of the standardized bid amount...

48 CFR 14.202-8 - Electronic bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Electronic bids. 14.202-8... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-8 Electronic bids. In accordance with subpart 4.5, contracting officers may authorize use of electronic commerce for submission of bids. If...

48 CFR 14.202-8 - Electronic bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Electronic bids. 14.202-8... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-8 Electronic bids. In accordance with subpart 4.5, contracting officers may authorize use of electronic commerce for submission of bids. If...

48 CFR 14.202-8 - Electronic bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Electronic bids. 14.202-8... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-8 Electronic bids. In accordance with subpart 4.5, contracting officers may authorize use of electronic commerce for submission of bids. If...

48 CFR 14.202-8 - Electronic bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Electronic bids. 14.202-8... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-8 Electronic bids. In accordance with subpart 4.5, contracting officers may authorize use of electronic commerce for submission of bids. If...

48 CFR 14.202-8 - Electronic bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Electronic bids. 14.202-8... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-8 Electronic bids. In accordance with subpart 4.5, contracting officers may authorize use of electronic commerce for submission of bids. If...

48 CFR 14.202-1 - Bidding time.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Bidding time. 14.202-1... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-1 Bidding time. (a) Policy. A reasonable time for prospective bidders to prepare and submit bids shall be allowed in all invitations, consistent...

48 CFR 14.202-1 - Bidding time.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Bidding time. 14.202-1... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-1 Bidding time. (a) Policy. A reasonable time for prospective bidders to prepare and submit bids shall be allowed in all invitations, consistent...

48 CFR 14.202-1 - Bidding time.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Bidding time. 14.202-1... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-1 Bidding time. (a) Policy. A reasonable time for prospective bidders to prepare and submit bids shall be allowed in all invitations, consistent...

48 CFR 14.202-1 - Bidding time.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Bidding time. 14.202-1... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-1 Bidding time. (a) Policy. A reasonable time for prospective bidders to prepare and submit bids shall be allowed in all invitations, consistent...

48 CFR 14.202-1 - Bidding time.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Bidding time. 14.202-1... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-1 Bidding time. (a) Policy. A reasonable time for prospective bidders to prepare and submit bids shall be allowed in all invitations, consistent...

Health information sources accessed by college females: differences between body-image distorted and non-body-image distorted.

PubMed

Nustad, Jill; Adams, Troy; Moore, Monique

2008-01-01

This study examined and compared sources of health-related information accessed by female college students with and without body image distortions, and the believability of those sources. Survey data from the American College Health Association, National College Health Assessment were studied retrospectively (N = 27,648). Body image distorted (BID) and non-BID students' most frequent health information sources were parents (76.1% BID; 77.1% non-BID) and internet (70.3% BID; 69.5% non-BID). Believability was greatest for health educators (90.6% BID; 91.1% non-BID) and lowest for television (14.4% BID; 14.5% non-BID). Health intervention strategies for college women should market to parents and teach recognition of credible internet sources of health information.

78 FR 55254 - Information Collection Being Reviewed by the Federal Communications Commission Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-10

... of their bids or bidding strategies from the short-form application filing deadline to the post... communication of bids or bidding strategies is limited to one applicant's bids or bidding strategies, it may unfairly disadvantage the other bidders in the market by creating an asymmetry of information. Section 1...

Study on Comparison of Bidding and Pricing Behavior Distinction between Estimate Methods

NASA Astrophysics Data System (ADS)

Morimoto, Emi; Namerikawa, Susumu

The most characteristic trend on bidding and pricing behavior distinction in recent years is the increasing number of bidders just above the criteria for low-price bidding investigations. The contractor's markup is the difference between the bidding price and the execution price. Therefore, the contractor's markup is the difference between criteria for low-price bidding investigations price and the execution price in the public works bid in Japan. Virtually, bidder's strategies and behavior have been controlled by public engineer's budgets. Estimation and bid are inseparably linked in the Japanese public works procurement system. The trial of the unit price-type estimation method begins in 2004. On another front, accumulated estimation method is one of the general methods in public works. So, there are two types of standard estimation methods in Japan. In this study, we did a statistical analysis on the bid information of civil engineering works for the Ministry of Land, Infrastructure, and Transportation in 2008. It presents several issues that bidding and pricing behavior is related to an estimation method (several estimation methods) for public works bid in Japan. The two types of standard estimation methods produce different results that number of bidders (decide on bid-no bid strategy) and distribution of bid price (decide on mark-up strategy).The comparison on the distribution of bid prices showed that the percentage of the bid concentrated on the criteria for low-price bidding investigations have had a tendency to get higher in the large-sized public works by the unit price-type estimation method, comparing with the accumulated estimation method. On one hand, the number of bidders who bids for public works estimated unit-price tends to increase significantly Public works estimated unit-price is likely to have been one of the factors for the construction companies to decide if they participate in the biddings.

Terror in the Board Room: The Bid-Opening Process

ERIC Educational Resources Information Center

Shoop, James

2009-01-01

Competitive bids and the bid-opening process are the cornerstones of public school purchasing. The bid-opening process does not begin on the day of the bid opening. It begins with good planning by the purchasing agent to ensure that the advertised bid complies with the public school contracts law. In New Jersey, that raises the following…

48 CFR 14.408-6 - Equal low bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Equal low bids. 14.408-6... AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-6 Equal low bids. (a) Contracts shall be awarded in the following order of priority when two or more low bids are equal in all...

COMPETITIVE BIDDING IN MEDICARE ADVANTAGE: EFFECT OF BENCHMARK CHANGES ON PLAN BIDS

PubMed Central

Song, Zirui; Landrum, Mary Beth; Chernew, Michael E.

2013-01-01

Bidding has been proposed to replace or complement the administered prices in Medicare pays to hospitals and health plans. In 2006, the Medicare Advantage program implemented a competitive bidding system to determine plan payments. In perfectly competitive models, plans bid their costs and thus bids are insensitive to the benchmark. Under many other models of competition, bids respond to changes in the benchmark. We conceptualize the bidding system and use an instrumental variable approach to study the effect of benchmark changes on bids. We use 2006–2010 plan payment data from the Centers for Medicare and Medicaid Services, published county benchmarks, actual realized fee-for-service costs, and Medicare Advantage enrollment. We find that a $1 increase in the benchmark leads to about a $0.53 increase in bids, suggesting that plans in the Medicare Advantage market have meaningful market power. PMID:24308881

Competitive bidding in Medicare Advantage: effect of benchmark changes on plan bids.

PubMed

Song, Zirui; Landrum, Mary Beth; Chernew, Michael E

2013-12-01

Bidding has been proposed to replace or complement the administered prices that Medicare pays to hospitals and health plans. In 2006, the Medicare Advantage program implemented a competitive bidding system to determine plan payments. In perfectly competitive models, plans bid their costs and thus bids are insensitive to the benchmark. Under many other models of competition, bids respond to changes in the benchmark. We conceptualize the bidding system and use an instrumental variable approach to study the effect of benchmark changes on bids. We use 2006-2010 plan payment data from the Centers for Medicare and Medicaid Services, published county benchmarks, actual realized fee-for-service costs, and Medicare Advantage enrollment. We find that a $1 increase in the benchmark leads to about a $0.53 increase in bids, suggesting that plans in the Medicare Advantage market have meaningful market power. Copyright © 2013 Elsevier B.V. All rights reserved.

Competitive bidding for Medicare Part B clinical laboratory services.

PubMed

Kautter, John; Pope, Gregory C

2014-06-01

The traditional Medicare fee-for-service program may be able to purchase clinical laboratory test services at a lower cost through competitive bidding. Demonstrations of competitive bidding for clinical laboratory tests have been twice mandated or authorized by Congress but never implemented. This article provides a summary and review of the final design of the laboratory competitive bidding demonstration mandated by the Medicare Modernization Act of 2003. The design was analogous to a sealed bid (first price), clearing price auction. Design elements presented include covered laboratory tests and beneficiaries, laboratory bidding and payment status under the demonstration, composite bids, determining bidding winners and the demonstration fee schedule, and quality under the demonstration. Expanded use of competitive bidding in Medicare, including specifically for clinical laboratory tests, has been recommended in some proposals for Medicare reform. The presented design may be a useful point of departure if Medicare clinical laboratory competitive bidding is revived in the future.

30 CFR 260.130 - What criteria does MMS use for selecting bidding systems and bidding system components?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What criteria does MMS use for selecting bidding systems and bidding system components? 260.130 Section 260.130 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OUTER CONTINENTAL SHELF OIL AND GAS LEASING Bidding Systems Bidding System Selection Criteria §...

NDI Acquisition. An Alternative to Business as Usual. Report of the DSMC 1991-1992 Military Research Fellows

DTIC Science & Technology

1992-10-01

sealed bidding and competitive proposals. governed by the same regulations and laws The sealed bidding procedure requires ade- that govern procurement ...Summary xiv NDI ACQUISITION: An Alternative to "Business as Usual" to successful, effective government procure - posal Cover Sheet). Moreover, the...became policy when the OPlP ;,;sued the first opment costs. These benefits may be offset by in a series of memoranda governing procure - performance

Laminarin-induced apoptosis in human colon cancer LoVo cells.

PubMed

Ji, Chen-Feng; Ji, Yu-Bin

2014-05-01

A number of scientific studies have revealed that laminarin has antitumor effects. Therefore, the aim of the present study was to investigate the apoptosis of LoVo cells and the underlying mechanisms induced by laminarin. LoVo cells were treated with various concentrations of laminarin and fluorescence-inverted microscopy was used to observe the morphology of LoVo cells treated with laminarin. In addition, western blotting was performed to analyze the expression levels of death receptor (DR)4, DR5, TNF-related apoptosis-inducing ligand (TRAIL), Fas-associated protein with death domain (FADD), caspase-8, caspase-3, Bid and tBid. Flow cytometry was conducted to analyze the expressions of Bcl-2 and Bax, and spectrophotometry was performed to quantify the activity of caspases-8, -3, -6 and -7. Following the treatment of LoVo cells with laminarin for 24 h, the expression levels of DR4, DR5, TRAIL, FADD, Bid, tBid and Bax were observed to be upregulated, whereas the expression levels of pro-caspase-8, pro-caspase-3 and Bcl-2 were downregulated. In addition, the activities of casapse-8, -3, -6 and -7 were observed to increase, which was a significant difference when compared with those of the control group. Therefore, laminarin is considered to induce the apoptosis of LoVo cells, which may occur via a DR pathway, suggesting that laminarin may be a potent agent for cancer treatment.

Laminarin-induced apoptosis in human colon cancer LoVo cells

PubMed Central

JI, CHEN-FENG; JI, YU-BIN

2014-01-01

A number of scientific studies have revealed that laminarin has antitumor effects. Therefore, the aim of the present study was to investigate the apoptosis of LoVo cells and the underlying mechanisms induced by laminarin. LoVo cells were treated with various concentrations of laminarin and fluorescence-inverted microscopy was used to observe the morphology of LoVo cells treated with laminarin. In addition, western blotting was performed to analyze the expression levels of death receptor (DR)4, DR5, TNF-related apoptosis-inducing ligand (TRAIL), Fas-associated protein with death domain (FADD), caspase-8, caspase-3, Bid and tBid. Flow cytometry was conducted to analyze the expressions of Bcl-2 and Bax, and spectrophotometry was performed to quantify the activity of caspases-8, -3, -6 and -7. Following the treatment of LoVo cells with laminarin for 24 h, the expression levels of DR4, DR5, TRAIL, FADD, Bid, tBid and Bax were observed to be upregulated, whereas the expression levels of pro-caspase-8, pro-caspase-3 and Bcl-2 were downregulated. In addition, the activities of casapse-8, -3, -6 and -7 were observed to increase, which was a significant difference when compared with those of the control group. Therefore, laminarin is considered to induce the apoptosis of LoVo cells, which may occur via a DR pathway, suggesting that laminarin may be a potent agent for cancer treatment. PMID:24765209

Real-time single cell analysis of Bid cleavage and translocation in cisplatin-induced apoptosis

NASA Astrophysics Data System (ADS)

Liu, Lei; Xing, Da; Pei, Yihui; Chen, Wei R.

2007-02-01

Cancer cell apoptosis can be induced by cisplatin, an efficient anticancer agent. However, its mechanism is not fully understood. Bcl-2 homology domain (BH) 3-only proteins couple stress signals to mitochondrial apoptotic pathways. Calpain-mediated cleavage of the BH3-only protein Bid into a 14 kD truncated protein (tBid) has been implicated in cisplatin-induced apoptotic pathway. We utilized a recombinant fluorescence resonance energy transfer (FRET) Bid probe to determine the kinetics of Bid cleavage during cisplatin-induced apoptosis in ASTC-a-1 cells. The cells were also co-transfected with Bid-CFP and DsRed-Mit to dynamically detect tBid translocation. Cells showed a cleavage of the Bid-FRET probe occurring at about 4-5 h after treated with 20 µM cisplatin. Cleavage of the Bid-FRET probe coincided with a translocation of tBid from the cytosolic to the mitochondria, and the translocation lasted about 1.5 h. Using real-time single-cell analysis, we first observed the kinetics of Bid cleavage and translocation to mitochondria in living cells during cisplatin-induced apoptosis.

Bid purchasing of pharmaceuticals.

PubMed

Swift, R G; Ryan, M R

1978-11-01

The effects of bid purchasing of drug products by hospitals and the factors to consider in bid purchasing of pharmaceuticals are reviewed; further, the prices available with bid purchasing to a specific hospital in 1974 and 1977 are presented. Factors important for a successful bid purchasing system of pharmaceuticals are: (1) use of a formulary policy, (2) an effective procedure for handling bid purchasing and (3) criteria for evaluation of drug products. Significant differences were found between prices available with and without bid purchasing for 50 nonproprietary drug products in 1974 and for 19 products in 1977. Although monetary savings to hospitals do exist with bid purchasing of pharmaceuticals, the degree of savings is dependent upon the drug usage for that hospital.

48 CFR 14.203 - Methods of soliciting bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Methods of soliciting bids. 14.203 Section 14.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.203 Methods of soliciting bids. ...

48 CFR 14.203 - Methods of soliciting bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Methods of soliciting bids. 14.203 Section 14.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.203 Methods of soliciting bids. ...

Bid Participates in Genotoxic Drug-Induced Apoptosis of HeLa Cells and Is Essential for Death Receptor Ligands' Apoptotic and Synergistic Effects

PubMed Central

Concannon, Caoimhin G.; Rehm, Markus; Kögel, Donat; Prehn, Jochen H. M.

2008-01-01

Background The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be cleaved by other proteases. Methodology/Principal Findings To test the hypothesis that Bid is a central mediator of stress-induced apoptosis, we investigated the effects of a small molecule Bid inhibitor on stress-induced apoptosis, and generated HeLa cells deficient for Bid. Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and TRAIL-induced caspase activation and apoptosis, and significantly increased clonogenic survival. While Bid-deficient cells were equally sensitive to ER stress-induced apoptosis, they showed moderate, but significantly reduced levels of apoptosis, as well as increased clonogenic survival in response to the genotoxic drugs Etoposide, Oxaliplatin, and Doxorubicin. Similar effects were observed using the Bid inhibitor BI6C9. Interestingly, Bid-deficient cells were dramatically protected from apoptosis when subtoxic concentrations of ER stressors, Etoposide or Oxaliplatin were combined with subtoxic TRAIL concentrations. Conclusions/Significance Our data demonstrate that Bid is central for death receptor-induced cell death and participates in anti-cancer drug-induced apoptosis in human cervical cancer HeLa cells. They also show that the synergistic effects of TRAIL in combination with either ER stressors or genotoxic anti-cancer drugs are nearly exclusively mediated via an increased activation of Bid-induced apoptosis signalling. PMID:18665234

Dynamic Interaction of cBid with Detergents, Liposomes and Mitochondria

PubMed Central

Bleicken, Stephanie; García-Sáez, Ana J.; Conte, Elena; Bordignon, Enrica

2012-01-01

The BH3-only protein Bid plays a key role in the induction of mitochondrial apoptosis, but its mechanism of action is still not completely understood. Here we studied the two main activation events of Bid: Caspase-8 cleavage and interaction with the membrane bilayer. We found a striking reversible behaviour of the dissociation-association events between the Bid fragments p15 and p7. Caspase-8 cleavage does not induce per se separation of the two Bid fragments, which remain in a stable complex resembling the full length Bid. Detergents trigger a complete dissociation, which can be fully reversed by detergent removal in a range of protein concentrations from 100 µM down to 500 nM. Incubation of cBid with cardiolipin-containing liposomes leads to partial dissociation of the complex. Only p15 (tBid) fragments are found at the membrane, while p7 shows no tendency to interact with the bilayer, but complete removal of p7 strongly increases the propensity of tBid to become membrane-associated. Despite the striking structural similarities of inactive Bid and Bax, Bid does not form oligomers and reacts differently in the presence of detergents and membranes, highlighting clear differences in the modes of action of the two proteins. The partial dissociation of cBid triggered by the membrane is suggested to depend on the strong and specific interaction between p15 and p7. The reversible disassembly and re-assembly of the cBid molecules at the membrane was as well proven by EPR using spin labeled cBid in the presence of isolated mitochondria. The observed dynamic dissociation of the two Bid fragments could allow the assistance to the pore-forming Bax to occur repeatedly and may explain the proposed “hit-and-run" mode of action of Bid at the bilayer. PMID:22540011

48 CFR 14.101 - Elements of sealed bidding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Elements of sealed bidding. 14.101 Section 14.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 14.101 Elements of sealed bidding...

48 CFR 14.101 - Elements of sealed bidding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Elements of sealed bidding. 14.101 Section 14.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 14.101 Elements of sealed bidding...

48 CFR 14.101 - Elements of sealed bidding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Elements of sealed bidding. 14.101 Section 14.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 14.101 Elements of sealed bidding...

48 CFR 14.101 - Elements of sealed bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Elements of sealed bidding. 14.101 Section 14.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 14.101 Elements of sealed bidding...

48 CFR 14.101 - Elements of sealed bidding.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Elements of sealed bidding. 14.101 Section 14.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 14.101 Elements of sealed bidding...

48 CFR 2014.407 - Mistakes in bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mistakes in bids. 2014.407 Section 2014.407 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 2014.407 Mistakes in bids. ...

36 CFR 223.88 - Bidding methods.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

36 CFR 223.88 - Bidding methods.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

A Bluff-Bidding Exercise

ERIC Educational Resources Information Center

Meister, J. Patrick

2011-01-01

Consider an auction in which one potential buyer wishes to participate, but the other potential buyer would rather the bidding not start. However, once bidding starts, the reluctant firm participates (submits "bluff bids") simply to make the eventual winner pay more. This incentive exists when the marginal effect of the winning bid is to increase…

36 CFR 223.88 - Bidding methods.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

36 CFR 223.88 - Bidding methods.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

24 CFR 291.304 - Bidding process.

Code of Federal Regulations, 2012 CFR

2012-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Sale of HUD-Held Single... HUD in accordance with instructions in the bid package for a particular sale. (b) Effect of bid. By... bid package. Along with the bid, the bidder must submit an executed copy of the Loan Sale Agreement...

24 CFR 291.304 - Bidding process.

Code of Federal Regulations, 2014 CFR

2014-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Sale of HUD-Held Single... HUD in accordance with instructions in the bid package for a particular sale. (b) Effect of bid. By... bid package. Along with the bid, the bidder must submit an executed copy of the Loan Sale Agreement...

24 CFR 291.304 - Bidding process.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF HUD-ACQUIRED SINGLE FAMILY PROPERTY Sale of HUD-Held Single... HUD in accordance with instructions in the bid package for a particular sale. (b) Effect of bid. By... bid package. Along with the bid, the bidder must submit an executed copy of the Loan Sale Agreement...

48 CFR 814.404-2 - Rejection of individual bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Rejection of individual... Rejection of individual bids. (a) When a contracting officer finds a bid that is being considered for an... nonresponsive an individual bid that is not in compliance with the Government's bid acceptance time, since...

24 CFR 291.304 - Bidding process.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Bidding process. 291.304 Section 291.304 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Family Mortgage Loans § 291.304 Bidding process. (a) Submission of bids. All bids must be submitted to...

Designing a Successful Bidding Strategy Using Fuzzy Sets and Agent Attitudes

NASA Astrophysics Data System (ADS)

Ma, Jun; Goyal, Madhu Lata

To be successful in a multi-attribute auction, agents must be capable of adapting to continuously changing bidding price. This chapter presents a novel fuzzy attitude-based bidding strategy (FA-Bid), which employs dual assessment technique, i.e., assessment of multiple attributes of the goods as well as assessment of agents' attitude (eagerness) to procure an item in automated auction. The assessment of attributes adapts the fuzzy sets technique to handle uncertainty of the bidding process as well use heuristic rules to determine the attitude of bidding agents in simulated auctions to procure goods. The overall assessment is used to determine a price range based on current bid, which finally selects the best one as the new bid.

Research on Bidding Decision-making of International Public-Private Partnership Projects

NASA Astrophysics Data System (ADS)

Hu, Zhen Yu; Zhang, Shui Bo; Liu, Xin Yan

2018-06-01

In order to select the optimal quasi-bidding project for an investment enterprise, a bidding decision-making model for international PPP projects was established in this paper. Firstly, the literature frequency statistics method was adopted to screen out the bidding decision-making indexes, and accordingly the bidding decision-making index system for international PPP projects was constructed. Then, the group decision-making characteristic root method, the entropy weight method, and the optimization model based on least square method were used to set the decision-making index weights. The optimal quasi-bidding project was thus determined by calculating the consistent effect measure of each decision-making index value and the comprehensive effect measure of each quasi-bidding project. Finally, the bidding decision-making model for international PPP projects was further illustrated by a hypothetical case. This model can effectively serve as a theoretical foundation and technical support for the bidding decision-making of international PPP projects.

Evolution of optimal Lévy-flight strategies in human mental searches

NASA Astrophysics Data System (ADS)

Radicchi, Filippo; Baronchelli, Andrea

2012-06-01

Recent analysis of empirical data [Radicchi, Baronchelli, and Amaral, PloS ONE1932-620310.1371/journal.pone.0029910 7, e029910 (2012)] showed that humans adopt Lévy-flight strategies when exploring the bid space in online auctions. A game theoretical model proved that the observed Lévy exponents are nearly optimal, being close to the exponent value that guarantees the maximal economical return to players. Here, we rationalize these findings by adopting an evolutionary perspective. We show that a simple evolutionary process is able to account for the empirical measurements with the only assumption that the reproductive fitness of the players is proportional to their search ability. Contrary to previous modeling, our approach describes the emergence of the observed exponent without resorting to any strong assumptions on the initial searching strategies. Our results generalize earlier research, and open novel questions in cognitive, behavioral, and evolutionary sciences.

32 CFR 172.5 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SALES OF SURPLUS PERSONAL PROPERTY § 172.5 Procedures. (a) Required bid deposits. When a sale conducted... apply: (1) Term bid. This type of bid deposit is applicable when the sale involves the purchase of scrap... of 20 percent of the bid shall accompany the bid. (b) Payment terms. When a sale conducted by a DoD...

48 CFR 2052.214-72 - Bid evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Bid evaluation. 2052.214-72... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.214-72 Bid evaluation. As... invitations for bids (paragraph “(f)” of this provision is optional): Bid Evaluation (JAN 1993) (a) Award will...

7 CFR 1780.95 - Public bidding on bonds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... public bidding. The Agency will not submit a bid at the advertised sale unless required by State law, nor... 7 Agriculture 12 2010-01-01 2010-01-01 false Public bidding on bonds. 1780.95 Section 1780.95... Bonds and Bond Transcript Documents for Public Body Applicants § 1780.95 Public bidding on bonds. Bonds...

31 CFR 356.14 - What are the requirements for submitting bids for customers?

Code of Federal Regulations, 2010 CFR

2010-07-01

... submitting bids for customers? 356.14 Section 356.14 Money and Finance: Treasury Regulations Relating to... requirements for submitting bids for customers? (a) Institutions that may submit bids for customers. Only depository institutions or dealers may submit bids for customers (see definitions at § 356.2), or for...

Bidding Agents That Perpetrate Auction Fraud

NASA Astrophysics Data System (ADS)

Trevathan, Jarrod; McCabe, Alan; Read, Wayne

This paper presents a software bidding agent that inserts fake bids on the seller's behalf to inflate an auction's price. This behaviour is referred to as shill bidding. Shill bidding is strictly prohibited by online auctioneers, as it defrauds unsuspecting buyers by forcing them to pay more for the item. The malicious bidding agent was constructed to aid in developing shill detection techniques. We have previously documented a simple shill bidding agent that incrementally increases the auction price until it reaches the desired profit target, or it becomes too risky to continue bidding. This paper presents an adaptive shill bidding agent which when used over a series of auctions with substitutable items, can revise its strategy based on bidding behaviour in past auctions. The adaptive agent applies a novel prediction technique referred to as the Extremum Consistency (EC) algorithm, to determine the optimal price to aspire for. The EC algorithm has successfully been used in handwritten signature verification for determining the maximum and minimum values in an input stream. The agent's ability to inflate the price has been tested in a simulated marketplace and experimental results are presented.

Competitive Bidding in a Certain Class of Auctions

NASA Astrophysics Data System (ADS)

Johansson, Mathias

2006-11-01

We consider the problem of determining the amount to bid in a certain type of auctions in which customers submit one sealed bid. The bid reflects the price a customer is willing to pay for one unit of the offered goods. The auction is repeated and at each auction each customer requests a certain amount of goods, an amount that we call the capacity of the customer and that varies among customers and over time. At each auction, only the customer with the largest bid-capacity product obtains any goods. The price paid by the winner equals his/her bid-capacity product, and the amount of goods obtained in return equals the winner's capacity. The auction is repeated many times, with only limited information concerning winning bid-capacity products being announced to the customers. This situation is motivated in for example wireless communication networks in which a possible way of obtaining a desired service level is to use dynamic pricing and competitive bidding. In this application, the capacity is typically uncertain when the bid is made. We derive bidding rules and loss functions for a few typical service requirements.

An analysis of competitive bidding by providers for indigent medical care contracts.

PubMed Central

Kirkman-Liff, B L; Christianson, J B; Hillman, D G

1985-01-01

This article develops a model of behavior in bidding for indigent medical care contracts in which bidders set bid prices to maximize their expected utility, conditional on estimates of variables which affect the payoff associated with winning or losing a contract. The hypotheses generated by this model are tested empirically using data from the first round of bidding in the Arizona indigent health care experiment. The behavior of bidding organizations in Arizona is found to be consistent in most respects with the predictions of the model. Bid prices appear to have been influenced by estimated costs and by expectations concerning the potential loss from not securing a contract, the initial wealth of the bidding organization, and the expected number of competitors in the bidding process. PMID:4086301

Overexpression of BID in thyroids of transgenic mice increases sensitivity to iodine-induced autoimmune thyroiditis

PubMed Central

2014-01-01

Background BID functions as a bridge molecule between death-receptor and mitochondrial related apoptotic pathways to amplify apoptotic signaling. Our previous studies have demonstrated a substantial increase in BID expression in primary normal thyroid epithelia cells treated with inflammatory cytokines, including the combination of IFNγ and IL-1β or IFNγ and TNFα. The aim of this study was to determine whether an increase in BID expression in thyroid can induce autoimmune thyroiditis. Methods A transgenic mouse line that expresses human BID in thyroid cells was established by fusing a mouse thyroglobulin (Tg) promoter upstream of human BID (Tg-BID). We tested whether the increased expression of pro-apoptotic BID in thyroid would induce autoimmune thyroiditis, both in the presence and absence of 0.3% iodine water. Results Our data show that Tg-BID mice in a CBA/J (H-2 k) background do not spontaneously develop autoimmune thyroiditis for over a year. However, upon ingestion of iodine in the drinking water, autoimmune thyroiditis does develop in Tg-BID transgenic mice, as shown by a significant increase in anti-Tg antibody and mononuclear cell infiltration in the thyroid glands in 30% of mice tested. Serum T4 levels, however, were similar between iodine-treated Tg-BID transgenic mice and the wild type mice. Conclusions Our data demonstrate that increased thyroid expression of BID facilitates the development of autoimmune thyroiditis induced by iodine uptake. However, the overexpression of BID itself is not sufficient to initiate thyroiditis in CBA/J (H-2 k) mice. PMID:24957380

A multicenter, randomized, prospective study of 14-day ranitidine bismuth citrate- vs. lansoprazole-based triple therapy for the eradication of Helicobacter pylori in dyspeptic patients.

PubMed

Avşar, Erol; Tiftikçi, Arzu; Poturoğlu, Sule; Erzin, Yusuf; Kocakaya, Ozan; Dinçer, Dinç; Yıldırım, Bulut; Güliter, Sefa; Türkay, Cansel; Yılmaz, Uğur; Onuk, Mehmet Derya; Bölükbaş, Cengiz; Ellidokuz, Ender; Bektaş, Ahmet; Taşan, Güralp; Aytuğ, Necip; Ateş, Yüksel; Kaymakoğlu, Sabahattin

2013-01-01

Proton-pump inhibitor and ranitidine bismuth citrate-based triple regimens are the two recommended first line treatments for the eradication of Helicobacter pylori. We aimed to compare the effectiveness and tolerability of these two treatments in a prospective, multicentric, randomized study. Patients with dyspeptic complaints were recruited from 15 study centers. Presence of Helicobacter pylori was investigated by both histology and rapid urease test. The patients were randomized to either ranitidine bismuth citrate 400 mg bid plus amoxicillin 1 g bid plus clarithromycin 500 mg bid (n=149) or lansoprazole 30 mg bid plus amoxicillin 1 g bid plus clarithromycin 500 mg bid (n=130) treatment arm for 14 days. Adverse events have been recorded during the treatment phase. A 13 C urea breath test was performed 6 weeks after termination of treatment to assess the efficacy of the therapy. Eradication rate was calculated by intention-to-treat and per-protocol analysis. Two hundred seventy-nine patients (123 male, 156 female) were eligible for randomization. In per-protocol analysis (n=247), Helicobacter pylori was eradicated with ranitidine bismuth citrate- and lansoprazole-based regimens in 74,6% and 69,2% of cases, respectively (p>0,05). Intention-to-treat analysis (n=279) revealed that eradication rates were 65,1% and 63,6% in ranitidine bismuth citrate and in lansoprazole-based regimens, respectively (p>0,05). Both regimes were well-tolerated, and no serious adverse event was observed during the study. Ranitidine bismuth citrate-based regimen is at least as effective and tolerable as the classical proton-pump inhibitor-based regimen, but none of the therapies could achieve the recommendable eradication rate.

30 CFR 260.130 - What criteria does MMS use for selecting bidding systems and bidding system components?

Code of Federal Regulations, 2011 CFR

2011-07-01

... system or tract, or may present a conflict that we will have to resolve in the process of bidding system... bidding systems and bidding system components? 260.130 Section 260.130 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OUTER CONTINENTAL...

Auctions to Reinforce Understanding

ERIC Educational Resources Information Center

Flores, Haynet Rivera

2018-01-01

An auction is a process of buying and selling goods or services by offering them up for bid, taking bids, and then selling each good or service to the highest bidder. Participants bid openly against one another; each bid must be higher than the previous bid. In the activity described rather than goods or services, English teachers sell sentences!…

48 CFR 14.401 - Receipt and safeguarding of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.401 Receipt and... identification, and then only by an official designated for this purpose. If a sealed bid is opened by mistake (e.g., because it is not marked as being a bid), the envelope shall be signed by the opener, whose...

30 CFR 260.111 - What conditions apply to the bidding systems that MMS uses?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What conditions apply to the bidding systems... INTERIOR OFFSHORE OUTER CONTINENTAL SHELF OIL AND GAS LEASING Bidding Systems General Provisions § 260.111 What conditions apply to the bidding systems that MMS uses? (a) For each of the bidding systems in...

MEG-BIDS, the brain imaging data structure extended to magnetoencephalography

PubMed Central

Niso, Guiomar; Gorgolewski, Krzysztof J.; Bock, Elizabeth; Brooks, Teon L.; Flandin, Guillaume; Gramfort, Alexandre; Henson, Richard N.; Jas, Mainak; Litvak, Vladimir; T. Moreau, Jeremy; Oostenveld, Robert; Schoffelen, Jan-Mathijs; Tadel, Francois; Wexler, Joseph; Baillet, Sylvain

2018-01-01

We present a significant extension of the Brain Imaging Data Structure (BIDS) to support the specific aspects of magnetoencephalography (MEG) data. MEG measures brain activity with millisecond temporal resolution and unique source imaging capabilities. So far, BIDS was a solution to organise magnetic resonance imaging (MRI) data. The nature and acquisition parameters of MRI and MEG data are strongly dissimilar. Although there is no standard data format for MEG, we propose MEG-BIDS as a principled solution to store, organise, process and share the multidimensional data volumes produced by the modality. The standard also includes well-defined metadata, to facilitate future data harmonisation and sharing efforts. This responds to unmet needs from the multimodal neuroimaging community and paves the way to further integration of other techniques in electrophysiology. MEG-BIDS builds on MRI-BIDS, extending BIDS to a multimodal data structure. We feature several data-analytics software that have adopted MEG-BIDS, and a diverse sample of open MEG-BIDS data resources available to everyone. PMID:29917016

MEG-BIDS, the brain imaging data structure extended to magnetoencephalography.

PubMed

Niso, Guiomar; Gorgolewski, Krzysztof J; Bock, Elizabeth; Brooks, Teon L; Flandin, Guillaume; Gramfort, Alexandre; Henson, Richard N; Jas, Mainak; Litvak, Vladimir; T Moreau, Jeremy; Oostenveld, Robert; Schoffelen, Jan-Mathijs; Tadel, Francois; Wexler, Joseph; Baillet, Sylvain

2018-06-19

We present a significant extension of the Brain Imaging Data Structure (BIDS) to support the specific aspects of magnetoencephalography (MEG) data. MEG measures brain activity with millisecond temporal resolution and unique source imaging capabilities. So far, BIDS was a solution to organise magnetic resonance imaging (MRI) data. The nature and acquisition parameters of MRI and MEG data are strongly dissimilar. Although there is no standard data format for MEG, we propose MEG-BIDS as a principled solution to store, organise, process and share the multidimensional data volumes produced by the modality. The standard also includes well-defined metadata, to facilitate future data harmonisation and sharing efforts. This responds to unmet needs from the multimodal neuroimaging community and paves the way to further integration of other techniques in electrophysiology. MEG-BIDS builds on MRI-BIDS, extending BIDS to a multimodal data structure. We feature several data-analytics software that have adopted MEG-BIDS, and a diverse sample of open MEG-BIDS data resources available to everyone.

47 CFR 25.403 - Bidding application and certification procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CARRIER SERVICES SATELLITE COMMUNICATIONS Competitive Bidding Procedures for DARS § 25.403 Bidding...'s name; (b) Mailing Address (no Post Office boxes); (c) City; (d) State; (e) ZIP Code; (f) Auction...

47 CFR 25.403 - Bidding application and certification procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CARRIER SERVICES SATELLITE COMMUNICATIONS Competitive Bidding Procedures for DARS § 25.403 Bidding...'s name; (b) Mailing Address (no Post Office boxes); (c) City; (d) State; (e) ZIP Code; (f) Auction...

Research on bidding quotation game of international project

NASA Astrophysics Data System (ADS)

Lin, Tao; Xu, Xin

2017-04-01

Bidding competition of international projects is more and more fierce currently. However, China started late relatively in the field, it is still lack of experience in the aspect of participation in bidding of international projects, and more effective bidding quotation system is not formed till present. Therefore, China can not win through systemic bidding quotation methods compared with many powerful bidding enterprises in the international field. Research on the field is also focused by many aspects as a result. It is urgent to solve related problems. Game theory is combined for analyzing the effectiveness and operability of bidding quotation models mainly based on current situation of bidding market in China international projects during research process in the paper. The research starts with the perspective of bidders for analyzing their game with tenderers and other bidders. The results have operational value aiming at bidders.

Developing Medicare Competitive Bidding: A Study of Clinical Laboratories

PubMed Central

Hoerger, Thomas J.; Meadow, Ann

1997-01-01

Competitive bidding to derive Medicare fees promises several advantages over administered fee systems. The authors show how incentives for cost savings, quality, and access can be incorporated into bidding schemes, and they report on a study of the clinical laboratory industry conducted in preparation for a bidding demonstration. The laboratory industry is marked by variable concentration across geographic markets and, among firms themselves, by social and economic heterogeneity. The authors conclude that these conditions can be accommodated by available bidding design options and by careful selection of bidding markets. PMID:10180003

New capacity bidding in Hungary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bakacs, I.

The paper gives a description of the regulatory and legal fundamentals of the new capacity bidding launched in 1997 in Hungary by MVM Rt, the transmission system operator. Some details of the regulations relevant to new generating capacity licensing are discussed with regard to the implementation of the new formal competitive bidding for the right to establish new or retrofitted (repowered) generating capacity. The paper presents the major tender rules and conditions. The bidding has attracted considerable interest. Because of the confidentiality of information no details are given on individual Bidders or bids, only some general statistical information is available.more » Due to the unexpectedly large interest and number of bids in the first stage of the bidding closed in January 1998 and some other events MVM has to change slightly some of the tender rules for the second stage announced in February. Final bids should be submitted by September 1998.« less

7 CFR 252.4 - Application to participate and agreement.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., bids awarded, or historical sales performance. FNS will make a final determination based on all...) The processor shall document that sales reported on monthly performance reports, specified in... in minimum truckload quantities; historical performance under the State and NCP processing programs...

Special experimental project (SEP-14) alternate surfacing bidding.

DOT National Transportation Integrated Search

2008-03-01

This report contains a discussion of the alternate bidding process used on a highway project in Kansas. : It discusses the background, bidding process, evaluation of the bids, and conclusions drawn from the : experience. It also includes a customer s...

Competitive bidding in Medicare: who benefits from competition?

PubMed

Song, Zirui; Landrum, Mary Beth; Chernew, Michael E

2012-09-01

To conduct the first empirical study of competitive bidding in Medicare. We analyzed 2006-2010 Medicare Advantage data from the Centers for Medicare and Medicaid Services using longitudinal models adjusted for market and plan characteristics. A $1 increase in Medicare's payment to health maintenance organization (HMO) plans led to a $0.49 (P <.001) increase in plan bids, with $0.34 (P <.001) going to beneficiaries in the form of extra benefits or lower cost sharing. With preferred provider organization and private fee-for-service plans included, higher Medicare payments increased bids less ($0.33 per dollar), suggesting more competition among these latter plans. As a market-based alternative to cost control through administrative pricing, competitive bidding relies on private insurance plans proposing prices they are willing to accept for insuring a beneficiary. However, competition is imperfect in the Medicare bidding market. As much as half of every dollar in increased plan payment went to higher bids rather than to beneficiaries. While having more insurers in a market lowered bids, the design of any bidding system for Medicare should recognize this shortcoming of competition.

48 CFR 6.401 - Sealed bidding and competitive proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... competitive proposals. 6.401 Section 6.401 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING COMPETITION REQUIREMENTS Sealed Bidding and Competitive Proposals 6.401 Sealed bidding and competitive proposals. Sealed bidding and competitive proposals, as described in Parts...

48 CFR 6.401 - Sealed bidding and competitive proposals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... competitive proposals. 6.401 Section 6.401 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING COMPETITION REQUIREMENTS Sealed Bidding and Competitive Proposals 6.401 Sealed bidding and competitive proposals. Sealed bidding and competitive proposals, as described in Parts...

47 CFR 1.2103 - Competitive bidding design options.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Competitive bidding design options. 1.2103 Section 1.2103 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Competitive Bidding Proceedings General Procedures § 1.2103 Competitive bidding design options. (a) The...

47 CFR 54.603 - Competitive bid requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 3 2011-10-01 2011-10-01 false Competitive bid requirements. 54.603 Section 54...) UNIVERSAL SERVICE Universal Service Support for Health Care Providers § 54.603 Competitive bid requirements. (a) Competitive bidding requirement. To select the telecommunications carriers that will provide...

The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes.

PubMed

König, Hans-Georg; Coughlan, Karen S; Kinsella, Sinéad; Breen, Bridget A; Prehn, Jochen H M

2014-10-01

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons in the spinal cord, brainstem and motor cortex. Mutations in the superoxide dismutase 1 (SOD1) gene represent a frequent genetic determinant and recapitulate a disease phenotype similar to ALS when expressed in mice. Previous studies using SOD1(G93A) transgenic mice have suggested a paracrine mechanism of neuronal loss, in which cytokines and other toxic factors released from astroglia or microglia trigger motoneuron degeneration. Several pro-inflammatory cytokines activate death receptors and may downstream from this activate the Bcl-2 family protein, Bid. We here sought to investigate the role of Bid in astrocyte activation and non-cell autonomous motoneuron degeneration. We found that spinal cord Bid protein levels increased significantly during disease progression in SOD1(G93A) mice. Subsequent experiments in vitro indicated that Bid was expressed at relatively low levels in motoneurons, but was enriched in astrocytes and microglia. Bid was strongly induced in astrocytes in response to pro-inflammatory cytokines or exposure to lipopolysaccharide. Experiments in bid-deficient astrocytes or astrocytes treated with a small molecule Bid inhibitor demonstrated that Bid was required for the efficient activation of transcription factor nuclear factor-κB in response to these pro-inflammatory stimuli. Finally, we found that conditioned medium from wild-type astrocytes, but not from bid-deficient astrocytes, was toxic when applied to primary motoneuron cultures. Collectively, our data demonstrate a new role for the Bcl-2 family protein Bid as a mediator of astrocyte activation during neuroinflammation, and suggest that Bid activation may contribute to non-cell autonomous motoneuron degeneration in ALS. Copyright © 2014 Elsevier Inc. All rights reserved.

42 CFR 422.254 - Submission of bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... part or may choose not to renew the contract. (4) Substantial differences between bids. An MA organization's bid submissions must reflect differences in benefit packages or plan costs that CMS determines to represent substantial differences relative to a sponsor's other bid submissions. (5) CMS may...

42 CFR 422.254 - Submission of bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... this part or may choose not to renew the contract. (4) Substantial differences between bids. An MA organization's bid submissions must reflect differences in benefit packages or plan costs that CMS determines to represent substantial differences relative to a sponsor's other bid submissions. (5) CMS may...

42 CFR 422.254 - Submission of bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... this part or may choose not to renew the contract. (4) Substantial differences between bids. An MA organization's bid submissions must reflect differences in benefit packages or plan costs that CMS determines to represent substantial differences relative to a sponsor's other bid submissions. (5) CMS may...

48 CFR 2014.201 - Preparation of invitation for bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparation of invitation for bids. 2014.201 Section 2014.201 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 2014.201 Preparation of...

Marginal Bidding: An Application of the Equimarginal Principle to Bidding in TAC SCM

NASA Astrophysics Data System (ADS)

Greenwald, Amy; Naroditskiy, Victor; Odean, Tyler; Ramirez, Mauricio; Sodomka, Eric; Zimmerman, Joe; Cutler, Clark

We present a fast and effective bidding strategy for the Trading Agent Competition in Supply Chain Management (TAC SCM). In TAC SCM, manufacturers compete to procure computer parts from suppliers (the procurement problem), and then sell assembled computers to customers in reverse auctions (the bidding problem). This paper is concerned only with bidding, in which an agent must decide how many computers to sell and at what prices to sell them. We propose a greedy solution, Marginal Bidding, inspired by the Equimarginal Principle, which states that revenue is maximized among possible uses of a resource when the return on the last unit of the resource is the same across all areas of use. We show experimentally that certain variations of Marginal Bidding can compute bids faster than our ILP solution, which enables Marginal Bidders to consider future demand as well as current demand, and hence achieve greater revenues when knowledge of the future is valuable.

Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers.

PubMed

Elger, Christian; Bialer, Meir; Falcão, Amílcar; Vaz-da-Silva, Manuel; Nunes, Teresa; Almeida, Luís; Soares-da-Silva, Patrício

2013-08-01

Investigate the pharmacokinetics of once-daily (QD; 900 mg) and twice-daily (BID; 450 mg) regimens of eslicarbazepine acetate (ESL) and BID (450 mg) regimen of oxcarbazepine (OXC) at steady state in healthy volunteers. Single-center, open-label, randomized, three-way (n = 12) crossover studies in healthy volunteers. Mean eslicarbazepine Cmax,ss (in μm) following ESL QD (87.3) was 33.3% higher (p < 0.05) compared to ESL BID (65.5) and 82.1% higher (p < 0.05) compared to OXC BID (48.0). The mean area under the curve (AUC)ss,0-τ (in μmol h/L) following the last dose of an 8-day repeated dosing was 1156.3, 1117.6, and 968.4 for ESL QD, ESL BID, and OXC BID, respectively. The ratio eslicarbazepine plasma exposure (μmol h/L) to ESL daily-dose (μmol) was 0.381 (1156.3:3037.3), 0.368 (1117.6:3037.3), and 0.271 (968.4:3567.6) for ESL-QD, ESL-BID, and OXC-BID, respectively, which translates into a 40.6% increase in the ability of ESL-QD compared to OXC-BID to deliver into the plasma their major active entity eslicarbazepine. The extent of plasma exposure to ESL minor metabolites: (R)-licarbazepine and oxcarbazepine after ESL-QD was 71.5% and 61.1% lower, respectively, than after OXC-BID. Twenty, 24 and 38 treatment emergent adverse events were reported with ESL-QD, ESL-BID, and OXC-BID, respectively. ESL-QD resulted in 33.3% higher peak plasma concentration (Cmax,ss ) of eslicarbazepine and similar extent of plasma exposure (AUCss,0-τ ) when compared to ESL-BID, which may contribute to the efficacy profile reported with once-daily ESL. In comparison to OXC-BID, administration of ESL-QD resulted in 40.6% increase in the delivery of eslicarbazepine into the plasma as well as a significantly lower systemic exposure to (R)-licarbazepine and oxcarbazepine. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

Competitive Bidding in Medicare: Who Benefits From Competition?

PubMed Central

Song, Zirui; Landrum, Mary Beth; Chernew, Michael E.

2012-01-01

Objectives To conduct the first empirical study of competitive bidding in Medicare. Study Design and Methods We analyzed 2006–2010 Medicare Advantage data from the Centers for Medicare & Medicaid Services using longitudinal models adjusted for market and plan characteristics. Results A $1 increase in Medicare's payment to health maintenance organization (HMO) plans led to a $0.49 (P <.001) increase in plan bids, with $0.34 (P <.001) going to beneficiaries in the form of extra benefits or lower cost sharing. With preferred provider organization and private fee-for-service plans included, higher Medicare payments increased bids less ($0.33 per dollar), suggesting more competition among these latter plans. Conclusions As a market-based alternative to cost control through administrative pricing, competitive bidding relies on private insurance plans proposing prices they are willing to accept for insuring a beneficiary. However, competition is imperfect in the Medicare bidding market. As much as half of every dollar in increased plan payment went to higher bids rather than to beneficiaries. While having more insurers in a market lowered bids, the design of any bidding system for Medicare should recognize this shortcoming of competition. PMID:23009305

36 CFR 223.231 - Bidding methods.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bidding methods. 223.231... methods. The Contracting Officer or designated forest officer shall offer advertised sales of special forest products through sealed bid or sealed bid followed by oral auction. The method selected shall: (a...

43 CFR 3923.10 - Minimum bid.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Minimum bid. 3923.10 Section 3923.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE LEASING Minimum Bid § 3923.10 Minimum bid...

43 CFR 3923.10 - Minimum bid.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Minimum bid. 3923.10 Section 3923.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE LEASING Minimum Bid § 3923.10 Minimum bid...

43 CFR 3923.10 - Minimum bid.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Minimum bid. 3923.10 Section 3923.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE LEASING Minimum Bid § 3923.10 Minimum bid...

48 CFR 814.304 - Submission, modification, and withdrawal of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Submission, modification, and withdrawal of bids. 814.304 Section 814.304 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Submission of Bids 814.304...

36 CFR 223.51 - Bid monitoring.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bid monitoring. 223.51 Section 223.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND... Bid monitoring. Each Regional Forester shall monitor bidding patterns on timber sales to determine if...

48 CFR 3414.406 - Mistakes in bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Mistakes in bids. 3414.406 Section 3414.406 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 3414.406 Mistakes...

Application of BIM technology in construction bidding

NASA Astrophysics Data System (ADS)

wei, Li

2017-12-01

bidding is a very important step of construction project. For the owners, bidding is the key link of selecting the best construction plan and saving the project cost to the maximum extent. For Construction Corporation, it is the key to show their construction technology which can improve the probability of winning the bid. this paper researches on the application of BIM technology in bidding process of construction project in detail, and discussesthe application of BIM technology in construction field comprehensively.

Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.

PubMed

Goonesinghe, Alexander; Mundy, Elizabeth S; Smith, Melanie; Khosravi-Far, Roya; Martinou, Jean-Claude; Esposti, Mauro D

2005-04-01

Bid is a BH3-only member of the Bcl-2 family that regulates cell death at the level of mitochondrial membranes. Bid appears to link the mitochondrial pathway with the death receptor-mediated pathway of cell death. It is generally assumed that the f.l. (full-length) protein becomes activated after proteolytic cleavage, especially by apical caspases like caspase 8. The cleaved protein then relocates to mitochondria and promotes membrane permeabilization, presumably by interaction with mitochondrial lipids and other Bcl-2 proteins that facilitate the release of apoptogenic proteins like cytochrome c. Although the major action may reside in the C-terminus part, tBid (cleaved Bid), un-cleaved Bid also has pro-apoptotic potential when ectopically expressed in cells or in vitro. This pro-apoptotic action of f.l. Bid has remained unexplained, especially at the biochemical level. In the present study, we show that f.l. (full-length) Bid can insert specific lysolipids into the membrane surface, thereby priming mitochondria for the release of apoptogenic factors. This is most effective for lysophosphatidylcholine species that we report to accumulate in mitochondria during apoptosis induction. A Bid mutant that is not pro-apoptotic in vivo is defective in lysophosphatidylcholine-mediated membrane perturbation in vitro. Our results thus provide a biochemical explanation for the pro-apoptotic action of f.l. Bid.

Improving the design of competitive bidding in Medicare Advantage.

PubMed

Cawley, John H; Whitford, Andrew B

2007-04-01

In 2003, Congress passed the Medicare Prescription Drug, Improvement, and Modernization Act, which required that in 2006 the Centers for Medicare and Medicaid Services (CMS) implement a system of competitive bids to set payments for the Medicare Advantage program. Managed care plans now bid for the right to enroll Medicare beneficiaries. Data from the first year of bidding suggest that imperfect competition is limiting the success of the bidding system. This article offers suggestions to improve this system based on findings from auction theory and previous government-run auctions. In particular, CMS can benefit by adjusting its system of competitive bids in four ways: credibly committing to regulations governing bidding; limiting the scope for collusion, entry deterrence, and predatory behavior among bidders; adjusting how benchmark reimbursement rates are set; and accounting for asymmetric information among bidders.

48 CFR 970.0970 - Performance guarantees.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Performance guarantees. 970.0970 Section 970.0970 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contractor Qualifications 970.0970 Performance...

48 CFR 970.0970 - Performance guarantees.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Performance guarantees. 970.0970 Section 970.0970 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contractor Qualifications 970.0970 Performance...

48 CFR 970.0970 - Performance guarantees.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Performance guarantees. 970.0970 Section 970.0970 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contractor Qualifications 970.0970 Performance...

48 CFR 970.0970 - Performance guarantees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance guarantees. 970.0970 Section 970.0970 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contractor Qualifications 970.0970 Performance...

48 CFR 252.217-7008 - Bonds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... persons supplying labor or materials in the performance of the work contemplated under the Master... annual bid bond (or evidence thereof) or an annual performance and payment bond (or evidence thereof). (b... Contracting Officer may nevertheless require a performance and payment bond, in form, amount, and with a...

42 CFR 423.265 - Submission of bids and related information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... to offer in the subsequent calendar year. (2) Substantial differences between bids. Potential Part D sponsors' bid submissions must reflect differences in benefit packages or plan costs that CMS determines to...) Bid submission—(1) General. Not later than the first Monday in June, each potential Part D sponsor...

42 CFR 423.265 - Submission of bids and related information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to offer in the subsequent calendar year. (2) Substantial differences between bids. Potential Part D sponsors' bid submissions must reflect differences in benefit packages or plan costs that CMS determines to...) Bid submission—(1) General. Not later than the first Monday in June, each potential Part D sponsor...

42 CFR 423.265 - Submission of bids and related information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... to offer in the subsequent calendar year. (2) Substantial differences between bids. Potential Part D sponsors' bid submissions must reflect differences in benefit packages or plan costs that CMS determines to...) Bid submission—(1) General. Not later than the first Monday in June, each potential Part D sponsor...

42 CFR 423.265 - Submission of bids and related information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... calendar year. (2) Substantial differences between bids. Potential Part D sponsors' bid submissions must reflect differences in benefit packages or plan costs that CMS determines to represent substantial...) General. Not later than the first Monday in June, each potential Part D sponsor must submit bids and...

42 CFR 423.265 - Submission of bids and related information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... calendar year. (2) Substantial differences between bids. Potential Part D sponsors' bid submissions must reflect differences in benefit packages or plan costs that CMS determines to represent substantial...) General. Not later than the first Monday in June, each potential Part D sponsor must submit bids and...

77 FR 61001 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

... currently approved collection; Title of Information Collection: Bid Pricing Tool (BPT) for Medicare... organizations (MAO) and Prescription Drug Plans (PDP) are required to submit an actuarial pricing ``bid'' for... PDPs use the Bid Pricing Tool (BPT) software to develop their actuarial pricing bid. The information...

36 CFR 223.231 - Bidding methods.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Bidding methods. 223.231... Forest Products Advertisement and Bids § 223.231 Bidding methods. The Contracting Officer or designated... followed by oral auction. The method selected shall: (a) Ensure open and fair competition; (b) Ensure that...

36 CFR 223.231 - Bidding methods.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Bidding methods. 223.231... Forest Products Advertisement and Bids § 223.231 Bidding methods. The Contracting Officer or designated... followed by oral auction. The method selected shall: (a) Ensure open and fair competition; (b) Ensure that...

36 CFR 223.231 - Bidding methods.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Bidding methods. 223.231... Forest Products Advertisement and Bids § 223.231 Bidding methods. The Contracting Officer or designated... followed by oral auction. The method selected shall: (a) Ensure open and fair competition; (b) Ensure that...

36 CFR 223.231 - Bidding methods.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Bidding methods. 223.231... Forest Products Advertisement and Bids § 223.231 Bidding methods. The Contracting Officer or designated... followed by oral auction. The method selected shall: (a) Ensure open and fair competition; (b) Ensure that...

48 CFR 252.236-7008 - Contract prices-bidding schedules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract prices-bidding... of Provisions And Clauses 252.236-7008 Contract prices—bidding schedules. As prescribed in 236.570(b)(6), use the following provision: Contract Prices—Bidding Schedules (DEC 1991) (a) The Government's...

43 CFR 3923.10 - Minimum bid.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Minimum bid. 3923.10 Section 3923.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) OIL SHALE LEASING Minimum Bid § 3923.10 Minimum bid. The...

47 CFR 90.801 - 900 MHz SMR spectrum subject to competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Competitive Bidding Procedures for 900 MHz Specialized Mobile Radio Service § 90.801 900 MHz SMR spectrum subject to competitive bidding. Mutually exclusive initial applications for 900 MHz SMR service licenses are subject to competitive bidding. The...

7 CFR 1435.502 - Bid selection procedures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM Processor Sugar Payment-In-Kind... acreage of sugar beets or sugarcane from production, CCC will rank bids on the basis of the bid amount as a percentage of the expected sugar produced from the retired acreage. Bids with the lowest of such...

48 CFR 14.401 - Receipt and safeguarding of bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Receipt and safeguarding of bids. 14.401 Section 14.401 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... bids shall be kept secure. Except as provided in paragraph (b) of this section, the bids shall not be...

48 CFR 14.401 - Receipt and safeguarding of bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Receipt and safeguarding of bids. 14.401 Section 14.401 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... bids shall be kept secure. Except as provided in paragraph (b) of this section, the bids shall not be...

10 CFR 452.5 - Bidding procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... cellulosic biofuels producers during the open window established in the solicitation. The open window shall.... (d) All bids will be confidential until 45 days after the close of the window for submission of bids... following: (1) After DOE evaluates the bids received during the open window, it shall, within 45 days...

75 FR 4701 - In the Matter of Procedural Amendments to Commission Part 1 Competitive Bidding Rules

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... Procedural Amendments to Commission Part 1 Competitive Bidding Rules AGENCY: Federal Communications... bidding rules. The Commission amends the rule specifying how to report potential violations of the prohibition on certain communications in order to reduce the risk that bidding-related information might be...

48 CFR 52.219-2 - Equal Low Bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Equal Low Bids. 52.219-2 Section 52.219-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES... Low Bids. As prescribed in 19.308(c), insert the following provision: Equal Low Bids (OCT 1995) (a...

48 CFR 970.3102-05-18 - Independent research and development and bid and proposal costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... development and bid and proposal costs. 970.3102-05-18 Section 970.3102-05-18 Federal Acquisition Regulations... Contract Cost Principles and Procedures 970.3102-05-18 Independent research and development and bid and proposal costs. (c) Independent Research and Development and Bid and Proposal costs are unallowable...

23 CFR 635.113 - Bid opening and bid tabulations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... permitted. (b) The STD shall prepare and forward tabulations of bids to the Division Administrator. These tabulations shall be certified by a responsible STD official and shall show: (1) Bid item details for at least... opened and reviewed in accordance with the terms of the solicitation. The STD must use its own procedures...

23 CFR 635.113 - Bid opening and bid tabulations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... permitted. (b) The STD shall prepare and forward tabulations of bids to the Division Administrator. These tabulations shall be certified by a responsible STD official and shall show: (1) Bid item details for at least... opened and reviewed in accordance with the terms of the solicitation. The STD must use its own procedures...

23 CFR 635.113 - Bid opening and bid tabulations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... permitted. (b) The STD shall prepare and forward tabulations of bids to the Division Administrator. These tabulations shall be certified by a responsible STD official and shall show: (1) Bid item details for at least... opened and reviewed in accordance with the terms of the solicitation. The STD must use its own procedures...

23 CFR 635.113 - Bid opening and bid tabulations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... permitted. (b) The STD shall prepare and forward tabulations of bids to the Division Administrator. These tabulations shall be certified by a responsible STD official and shall show: (1) Bid item details for at least... opened and reviewed in accordance with the terms of the solicitation. The STD must use its own procedures...

48 CFR 1303.104-4 - Disclosure, protection and marking of contractor bid or proposal information and source selection...

Code of Federal Regulations, 2010 CFR

2010-10-01

... marking of contractor bid or proposal information and source selection information. 1303.104-4 Section... PRACTICES AND PERSONAL CONFLICTS OF INTEREST Safeguards 1303.104-4 Disclosure, protection and marking of contractor bid or proposal information and source selection information. Contractor bid or proposal...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Review, negotiation, and approval of bids. 422.256..., and Related Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a... aggregate bid amounts submitted under § 422.252 and conduct negotiations with MA organizations regarding...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Review, negotiation, and approval of bids. 422.256..., and Related Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a... aggregate bid amounts submitted under § 422.252 and conduct negotiations with MA organizations regarding...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Review, negotiation, and approval of bids. 422.256..., and Related Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a... aggregate bid amounts submitted under § 422.252 and conduct negotiations with MA organizations regarding...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Review, negotiation, and approval of bids. 422.256... Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a) Authority. Subject to... submitted under § 422.252 and conduct negotiations with MA organizations regarding these bids (including the...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Review, negotiation, and approval of bids. 422.256... Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a) Authority. Subject to... submitted under § 422.252 and conduct negotiations with MA organizations regarding these bids (including the...

48 CFR 603.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and marking of contractor bid or proposal information and source selection information. 603.104-4... contractor bid or proposal information and source selection information. (a) The following classes of persons may be authorized to receive contractor bid or proposal information or source selection information by...

43 CFR 3422.3-1 - Bidding systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Bidding systems. 3422.3-1 Section 3422.3-1... systems. (a) The provisions of 10 CFR part 378 1 are not applicable to this part. 1 Redesignated as 30 CFR... cash bonus—fixed royalty bidding systems or any other bidding system adopted through rulemaking...

43 CFR 3422.3-1 - Bidding systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Bidding systems. 3422.3-1 Section 3422.3-1... systems. (a) The provisions of 10 CFR part 378 1 are not applicable to this part. 1 Redesignated as 30 CFR... cash bonus—fixed royalty bidding systems or any other bidding system adopted through rulemaking...

48 CFR 14.302 - Bid submission.

Code of Federal Regulations, 2010 CFR

2010-10-01

... paragraphs (b) and (c) below as the designated office) not later than the exact time set for opening of bids... later than the time set for the bid opening; (4) The telegraph office that received the telegraphic bid... indicates on its face that it was received in the telegraph office before the telephone call was received by...

75 FR 57052 - Notice of Single Family Loan Sale (SFLS 2010)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... submitted and determine the successful bid or bids, in terms of the best value to HUD, in its sole and... Sale (SFLS 2010) AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner... insurance, in a competitive, sealed bid sale (SFLS 2010). This notice also generally describes the bidding...

23 CFR 635.112 - Advertising for bids and proposals.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Advertising for bids and proposals. 635.112 Section 635... OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.112 Advertising for bids and proposals. (a) No work shall be undertaken on any Federal-aid project, nor shall any project be advertised for bids...

47 CFR 22.217 - Bidding credit for small businesses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Bidding credit for small businesses. 22.217... Bidding credit for small businesses. A winning bidder that qualifies as a small business, as defined in § 22.223(b)(1), or a consortium of small businesses may use a bidding credit of thirty-five (35...

43 CFR 5442.3 - Rejection of bids; waiver of minor deficiencies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Rejection of bids; waiver of minor... Procedure § 5442.3 Rejection of bids; waiver of minor deficiencies. When the authorized officer determines... minor deficiencies in the bids or the timber sale advertisement. [38 FR 6280, Mar. 8, 1973] ...

47 CFR 22.217 - Bidding credit for small businesses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Bidding credit for small businesses. 22.217... Bidding credit for small businesses. A winning bidder that qualifies as a small business, as defined in § 22.223(b)(1), or a consortium of small businesses may use a bidding credit of thirty-five (35...

47 CFR 22.217 - Bidding credit for small businesses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 2 2011-10-01 2011-10-01 false Bidding credit for small businesses. 22.217... Bidding credit for small businesses. A winning bidder that qualifies as a small business, as defined in § 22.223(b)(1), or a consortium of small businesses may use a bidding credit of thirty-five (35...

47 CFR 22.217 - Bidding credit for small businesses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Bidding credit for small businesses. 22.217... Bidding credit for small businesses. A winning bidder that qualifies as a small business, as defined in § 22.223(b)(1), or a consortium of small businesses may use a bidding credit of thirty-five (35...

47 CFR 22.217 - Bidding credit for small businesses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 2 2012-10-01 2012-10-01 false Bidding credit for small businesses. 22.217... Bidding credit for small businesses. A winning bidder that qualifies as a small business, as defined in § 22.223(b)(1), or a consortium of small businesses may use a bidding credit of thirty-five (35...

Green auctions and reduction of information rents in payments for environmental services: an experimental investigation in Sunan County, northwestern China.

PubMed

Deng, Xiaohong; Xu, Zhongmin

2015-01-01

Reducing information rents is an important task for government agencies wishing to purchase maximal environmental services with limited budgets. This paper reports on several green auction options for reducing information rents and improving the performance of the "Grain for Green" Payments for environmental services (PES) program implemented in northwestern China. In r experimental auctions and investigations, door-to-door interviews were conducted and bidding envelopes and survey questionnaires were used to determine the offers and the foregone profits of the participants. Three scenarios are analyzed in this paper: a uniform price auction, a discriminatory price auction, and an opportunity-cost system. The results show that compared to the uniform price auction system, the other auction systems can increase the cost-effectiveness of conservation contracting. Competitive bidding can reveal true opportunity costs and can reduce information rents extracted from the government by farmers using private information. The demographics and average bids of these auction types were also analyzed. "Perfect information" in the opportunity-cost offer system has the best performance but is very hard to implement in reality. The results of this research show that the auction is a valuable tool for purchasing conservation contracts in northwestern China, but that in the future, the performance of these auctions should be studied with relaxed model assumptions.

Green Auctions and Reduction of Information Rents in Payments for Environmental Services: An Experimental Investigation in Sunan County, Northwestern China

PubMed Central

Deng, Xiaohong; Xu, Zhongmin

2015-01-01

Reducing information rents is an important task for government agencies wishing to purchase maximal environmental services with limited budgets. This paper reports on several green auction options for reducing information rents and improving the performance of the “Grain for Green” Payments for environmental services (PES) program implemented in northwestern China. In r experimental auctions and investigations, door-to-door interviews were conducted and bidding envelopes and survey questionnaires were used to determine the offers and the foregone profits of the participants. Three scenarios are analyzed in this paper: a uniform price auction, a discriminatory price auction, and an opportunity-cost system. The results show that compared to the uniform price auction system, the other auction systems can increase the cost-effectiveness of conservation contracting. Competitive bidding can reveal true opportunity costs and can reduce information rents extracted from the government by farmers using private information. The demographics and average bids of these auction types were also analyzed. “Perfect information” in the opportunity-cost offer system has the best performance but is very hard to implement in reality. The results of this research show that the auction is a valuable tool for purchasing conservation contracts in northwestern China, but that in the future, the performance of these auctions should be studied with relaxed model assumptions. PMID:25793263

Central Gulf of Mexico lease sale draws weak industry response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koen, A.D.

This paper reports that interest in oil and gas leases in the Gulf of Mexico continued spiraling downward at the latest Minerals Management Service offshore sale. Companies participating in Outer Continental Shelf Sale 139 last week in New Orleans offered 196 bids for 151 blocks in the central Gulf of Mexico. MMS offered 5,213 blocks for lease. The number of tracts receiving bids was the fewest at a central gulf lease sale since 114 tracts garnered high bids totaling $146.4 million at Sale 104 in April 1986. Apparent high bids in Sale 139 totaled $56,195,552, and all bids offered totaledmore » just $65,300,864. Both bidding totals were the lowest in a Gulf of Mexico lease sale since MMS began area-wide gulf leasing at Sale 72 in May 1983. Only 64 of 93 qualified companies participated in Sale 139. Fifty-five companies offered apparent winning bids. By comparison, 123 companies at central gulf lease Sale 131 in March 1991 offered 637 bids totaling $320.5 million for 464 tracts. Apparent high bids last spring totaled $259.9 million. At central gulf lease Sale 123 in March 1990, high bids totaled $427.4 million for 538 tracts. In that sale, BP Exploration Inc. led all bidders, exposing $78 million in 79 high bids, including 60 for deepwater tracts. Since then, interest in deepwater tracts has waned in part because of sagging oil and gas prices as U.S. operators sought bigger prospects outside the U.S. Ironically, Sale 139 was dominated by the U.S. subsidiary of an Italian holding company.« less

Antimicrobial susceptibility testing before first-line treatment for Helicobacter pylori infection in patients with dual or triple antibiotic resistance.

PubMed

Cosme, Angel; Montes, Milagrosa; Ibarra, Begoña; Tamayo, Esther; Alonso, Horacio; Mendarte, Usua; Lizasoan, Jacobo; Herreros-Villanueva, Marta; Bujanda, Luis

2017-05-14

To evaluate the efficacy of antimicrobial susceptibility-guided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance. A total of 1034 patients infected by Helicobacter pylori ( H. pylori ) during 2013-2014 were tested for antimicrobial susceptibility. 157 of 1034 (15%) patients showed resistance to two (127/1034; 12%) and to three (30/1034; 3%) antibiotics. Sixty-eight patients with dual H. pylori -resistance (clarithromycin, metronidazole or levofloxacin) were treated for 10 d with triple therapies: OAL (omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and levofloxacin 500 mg b.i.d.) 43 cases, OAM (omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and metronidazole 500 mg b.i.d.) 12 cases and OAC (omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d.) 13 cases based on the antimicrobial susceptibility testing. Twelve patients showed triple H. pylori -resistance (clarithromycin, metronidazole and levofloxacin) and received for 10 d triple therapy with OAR (omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and rifabutin 150 mg b.i.d.). Eradication was confirmed by 13C-urea breath test. Adverse effects and compliance were assessed by a questionnaire. Intention-to-treat eradication rates were: OAL (97.6%), OAM (91.6%), OAC (92.3%) and OAR (58.3%). Cure rate was significantly higher in naïve patients treated with OAR-10 compared to patients who had two or three previous treatment failures (83% vs 33%). Adverse events rates for OAL, OAM, OAC and OAR were 22%, 25%, 23% and 17%, respectively, all of them mild-moderate. Antimicrobial susceptibility-guided triple therapies during 10 d for first-line treatment leads to an eradication rate superior to 90% in patients with dual antibiotic H. pylori resistance.

Smart Computer-Assisted Markets

NASA Astrophysics Data System (ADS)

McCabe, Kevin A.; Rassenti, Stephen J.; Smith, Vernon L.

1991-10-01

The deregulation movement has motivated the experimental study of auction markets designed for interdependent network industries such as natural gas pipelines or electric power systems. Decentralized agents submit bids to buy commodity and offers to sell transportation and commodity to a computerized dispatch center. Computer algorithms determine prices and allocations that maximize the gains from exchange in the system relative to the submitted bids and offers. The problem is important, because traditionally the scale and coordination economies in such industries were thought to require regulation. Laboratory experiments are used to study feasibility, limitations, incentives, and performance of proposed market designs for deregulation, providing motivation for new theory.

Cryptographic Combinatorial Securities Exchanges

NASA Astrophysics Data System (ADS)

Thorpe, Christopher; Parkes, David C.

We present a useful new mechanism that facilitates the atomic exchange of many large baskets of securities in a combinatorial exchange. Cryptography prevents information about the securities in the baskets from being exploited, enhancing trust. Our exchange offers institutions who wish to trade large positions a new alternative to existing methods of block trading: they can reduce transaction costs by taking advantage of other institutions’ available liquidity, while third party liquidity providers guarantee execution—preserving their desired portfolio composition at all times. In our exchange, institutions submit encrypted orders which are crossed, leaving a “remainder”. The exchange proves facts about the portfolio risk of this remainder to third party liquidity providers without revealing the securities in the remainder, the knowledge of which could also be exploited. The third parties learn either (depending on the setting) the portfolio risk parameters of the remainder itself, or how their own portfolio risk would change if they were to incorporate the remainder into a portfolio they submit. In one setting, these third parties submit bids on the commission, and the winner supplies necessary liquidity for the entire exchange to clear. This guaranteed clearing, coupled with external price discovery from the primary markets for the securities, sidesteps difficult combinatorial optimization problems. This latter method of proving how taking on the remainder would change risk parameters of one’s own portfolio, without revealing the remainder’s contents or its own risk parameters, is a useful protocol of independent interest.

Pharmacoeconomic comparison of Helicobacter pylori eradication regimens.

PubMed

Sancar, Mesut; Izzettin, Fikret Vehbi; Apikoglu-Rabus, Sule; Besisik, Fatih; Tozun, Nurdan; Dulger, Gul

2006-08-01

Helicobacter pylori is the most important etiologic agent for development of peptic ulcer, chronic gastritis and gastric carcinomas. It is now well established that H. pylori eradication treatment is more cost-effective than acid suppressing therapies alone for the treatment of peptic ulcer disease. However, the comparative cost-effectiveness of various H. pylori eradication regimens is still not clear. This study was designed to make a pharmacoeconomic comparison of different H. pylori eradication regimens in patients with peptic ulcer disease or chronic gastritis, using real-world cost and effectiveness data. Istanbul University Hospital and Marmara University Hospital. A total of 75 patients diagnosed as H. pylori (+) by endoscopy were randomized to receive one of the seven H. pylori treatment protocols. These protocols were as follows: (LAC) = 'lansoprazole 30 mg bid + amoxicillin 1 g bid + clarithromycin 500 mg bid' for 7 days and (OCM) = 'omeprazole 20 mg bid + clarithromycin 250 mg bid + metronidazole 500 mg bid'; (OAM) = 'omeprazole 40 mg qd + amoxicillin 500 mg tid + metronidazole 500 mg tid'; (MARB) = 'metronidazole 250 mg tid + amoxicillin 500 mg qid + ranitidine 300 mg hs + bismuth 300 mg qid'; (OAC) = omeprazole 20 mg bid + amoxicillin 1 g bid + clarithromycin 500 mg bid'; (OCA) = omeprazole 40 mg bid + clarithromycin 500 mg bid + amoxicillin 1 g bid'; (OAB) = 'omeprazole 20 mg bid + amoxicillin 500 mg tid + bismuth 300 mg qid' each for 14 days. Only direct costs were included in the analysis. Effectiveness was measured in terms of "successful eradication". The cost-effectiveness ratios of the regimens were calculated using these effectiveness and cost data. The perspective of the study was assumed as the Government's perspective. Cost-effectiveness ratios of eradication regimens. MARB and OCA regimens were found to be more cost-effective than the other treatment regimens. The eradication rates and cost-effectiveness ratios calculated for these protocols were 90% (158.7 euros) for MARB and 90% (195.8 euros) for OCA regimen. This study confirms the importance of using local pharmacoeconomic data. Analyses such as this give decision-makers the tools to choose a better treatment option which is both highly effective yet and has a low cost.

76 FR 74749 - Small Business Subcontracting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... amend its regulations to implement provisions of the Small Business Jobs Act of 2010 (Jobs Act... used in preparing its bid or proposal during contract performance. SBA also proposed to amend its... and evaluating small business subcontracting plan performance. SBA also proposed to clarify which...

25 CFR 166.221 - How do I acquire an advertised permit through competitive bidding?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false How do I acquire an advertised permit through competitive... permit through competitive bidding? (a) As part of the negotiation of a permit, Indian landowners may... responsible bidder(s), which may require further competitive bidding after the bid opening; and (4) Prepare...

25 CFR 166.221 - How do I acquire an advertised permit through competitive bidding?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false How do I acquire an advertised permit through competitive... permit through competitive bidding? (a) As part of the negotiation of a permit, Indian landowners may... responsible bidder(s), which may require further competitive bidding after the bid opening; and (4) Prepare...

76 FR 73654 - Notice of Single Family Loan Sales (SFLS 2012-1)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... will evaluate the bids submitted and determine the successful bid, in terms of the best value to HUD... Sales (SFLS 2012-1) AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner... describes the bidding process for the sale and certain persons who are ineligible to bid. This first sale of...

76 FR 55936 - Notice of Single Family Loan Sales (SFLS 2011-3)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... will evaluate the bids submitted and determine the successful bid, in terms of the best value to HUD... Sales (SFLS 2011-3) AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner... describes the bidding process for the sale and certain persons who are ineligible to bid. This third sale of...

26 CFR 403.61 - Sale on open, competitive bids.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Sale on open, competitive bids. 403.61 Section... open, competitive bids. If forfeited property is to be sold at public auction to the highest bidder on open, competitive bids, the notice of sale shall so specify, and state the date, hour, and place of...

26 CFR 403.61 - Sale on open, competitive bids.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Sale on open, competitive bids. 403.61 Section... open, competitive bids. If forfeited property is to be sold at public auction to the highest bidder on open, competitive bids, the notice of sale shall so specify, and state the date, hour, and place of...

26 CFR 403.61 - Sale on open, competitive bids.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Sale on open, competitive bids. 403.61 Section... open, competitive bids. If forfeited property is to be sold at public auction to the highest bidder on open, competitive bids, the notice of sale shall so specify, and state the date, hour, and place of...

26 CFR 403.61 - Sale on open, competitive bids.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Sale on open, competitive bids. 403.61 Section... open, competitive bids. If forfeited property is to be sold at public auction to the highest bidder on open, competitive bids, the notice of sale shall so specify, and state the date, hour, and place of...

26 CFR 403.61 - Sale on open, competitive bids.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Sale on open, competitive bids. 403.61 Section... open, competitive bids. If forfeited property is to be sold at public auction to the highest bidder on open, competitive bids, the notice of sale shall so specify, and state the date, hour, and place of...

25 CFR 215.8 - Submission of bids.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Submission of bids. 215.8 Section 215.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING OPERATIONS AND LEASES, QUAPAW AGENCY § 215.8 Submission of bids. At the time of public auction bidders may submit their bids in...

47 CFR 101.1208 - Bidding credits for small businesses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bidding credits for small businesses. 101.1208... Bidding credits for small businesses. A winning bidder that qualifies as a small business or a consortium of small businesses, (as defined in § 101.1209(b)(1)(i) may use a bidding credit of 25 percent to...

47 CFR 90.810 - Bidding credits for small businesses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bidding credits for small businesses. 90.810... Radio Service § 90.810 Bidding credits for small businesses. A winning bidder that qualifies as a small business, as defined in § 90.814(b)(1), or a consortium of small businesses may use a bidding credit of 15...

47 CFR 1.2105 - Bidding application and certification procedures; prohibition of certain communications.

Code of Federal Regulations, 2010 CFR

2010-10-01

....2110, a statement to that effect and a declaration, under penalty of perjury, that the applicant is... the post-auction market structure. (ix) Certification under penalty of perjury that it has not entered... amount of their bids, bidding strategies or the particular licenses on which they will or will not bid...

47 CFR 90.810 - Bidding credits for small businesses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Bidding credits for small businesses. 90.810... Radio Service § 90.810 Bidding credits for small businesses. A winning bidder that qualifies as a small business, as defined in § 90.814(b)(1), or a consortium of small businesses may use a bidding credit of 15...

47 CFR 90.810 - Bidding credits for small businesses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bidding credits for small businesses. 90.810... Radio Service § 90.810 Bidding credits for small businesses. A winning bidder that qualifies as a small business, as defined in § 90.814(b)(1), or a consortium of small businesses may use a bidding credit of 15...

47 CFR 101.1208 - Bidding credits for small businesses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Bidding credits for small businesses. 101.1208... Bidding credits for small businesses. A winning bidder that qualifies as a small business or a consortium of small businesses, (as defined in § 101.1209(b)(1)(i) may use a bidding credit of 25 percent to...

47 CFR 90.810 - Bidding credits for small businesses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Bidding credits for small businesses. 90.810... Radio Service § 90.810 Bidding credits for small businesses. A winning bidder that qualifies as a small business, as defined in § 90.814(b)(1), or a consortium of small businesses may use a bidding credit of 15...

47 CFR 101.1208 - Bidding credits for small businesses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Bidding credits for small businesses. 101.1208... Bidding credits for small businesses. A winning bidder that qualifies as a small business or a consortium of small businesses, (as defined in § 101.1209(b)(1)(i) may use a bidding credit of 25 percent to...

47 CFR 90.810 - Bidding credits for small businesses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Bidding credits for small businesses. 90.810... Radio Service § 90.810 Bidding credits for small businesses. A winning bidder that qualifies as a small business, as defined in § 90.814(b)(1), or a consortium of small businesses may use a bidding credit of 15...

47 CFR 101.1208 - Bidding credits for small businesses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bidding credits for small businesses. 101.1208... Bidding credits for small businesses. A winning bidder that qualifies as a small business or a consortium of small businesses, (as defined in § 101.1209(b)(1)(i) may use a bidding credit of 25 percent to...

47 CFR 101.1208 - Bidding credits for small businesses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Bidding credits for small businesses. 101.1208... Bidding credits for small businesses. A winning bidder that qualifies as a small business or a consortium of small businesses, (as defined in § 101.1209(b)(1)(i) may use a bidding credit of 25 percent to...

Hospital materials managers need to be aware of actions that constitute legal acceptance.

PubMed

Decker, R

1990-12-01

A hospital invited bids for building materials for a hospital construction project. A supplier submitted a bid which asked the hospital to sign and return a trade association form contract. The hospital didn't return the form but used the supplier's bid as part of the general contract for the entire project and notified the supplier and the general contractor. Later, the supplier submitted a higher bid for the same material contending that the hospital hadn't accepted the first bid as they hadn't followed the instructions. The hospital materials manager feels that the bid was properly accepted. In this dialogue, Dr. Decker reviews the legal issues involved in the different ways of accepting an offer.

Neural-Learning-Based Telerobot Control With Guaranteed Performance.

PubMed

Yang, Chenguang; Wang, Xinyu; Cheng, Long; Ma, Hongbin

2017-10-01

In this paper, a neural networks (NNs) enhanced telerobot control system is designed and tested on a Baxter robot. Guaranteed performance of the telerobot control system is achieved at both kinematic and dynamic levels. At kinematic level, automatic collision avoidance is achieved by the control design at the kinematic level exploiting the joint space redundancy, thus the human operator would be able to only concentrate on motion of robot's end-effector without concern on possible collision. A posture restoration scheme is also integrated based on a simulated parallel system to enable the manipulator restore back to the natural posture in the absence of obstacles. At dynamic level, adaptive control using radial basis function NNs is developed to compensate for the effect caused by the internal and external uncertainties, e.g., unknown payload. Both the steady state and the transient performance are guaranteed to satisfy a prescribed performance requirement. Comparative experiments have been performed to test the effectiveness and to demonstrate the guaranteed performance of the proposed methods.

The HARMONY Trial: Combined Ranolazine and Dronedarone in the Management of Paroxysmal Atrial Fibrillation: Mechanistic and Therapeutic Synergism.

PubMed

Reiffel, James A; Camm, A John; Belardinelli, Luiz; Zeng, Dewan; Karwatowska-Prokopczuk, Ewa; Olmsted, Ann; Zareba, Wojciech; Rosero, Spencer; Kowey, Peter

2015-10-01

Atrial fibrillation (AF) requires arrhythmogenic changes in atrial ion channels/receptors and usually altered atrial structure. AF is commonly treated with antiarrhythmic drugs; the most effective block many ion channels/receptors. Modest efficacy, intolerance, and safety concerns limit current antiarrhythmic drugs. We hypothesized that combining agents with multiple anti-AF mechanisms at reduced individual drug doses might produce synergistic efficacy plus better tolerance/safety. HARMONY tested midrange ranolazine (750 mg BID) combined with 2 reduced dronedarone doses (150 mg BID and 225 mg BID; chosen to reduce dronedarone's negative inotropic effect-see text below) over 12 weeks in 134 patients with paroxysmal AF and implanted pacemakers where AF burden (AFB) could be continuously assessed. Patients were randomized double-blind to placebo, ranolazine alone (750 mg BID), dronedarone alone (225 mg BID), or one of the combinations. Neither placebo nor either drugs alone significantly reduced AFB. Conversely, ranolazine 750 mg BID/dronedarone 225 mg BID reduced AFB by 59% versus placebo (P=0.008), whereas ranolazine 750 mg BID/dronedarone 150 mg BID reduced AFB by 43% (P=0.072). Both combinations were well tolerated. HARMONY showed synergistic AFB reduction by moderate dose ranolazine plus reduced dose dronedarone, with good tolerance/safety, in the population enrolled. ClinicalTrials.gov; Unique identifier: NCT01522651. © 2015 American Heart Association, Inc.

The association between obesity, depression, and educational attainment in women: The mediating role of body image dissatisfaction

PubMed Central

Gavin, Amelia R.; Simon, Greg E.; Ludman, Evette J.

2011-01-01

Objective We examine the mediating role of body image dissatisfaction (BID) on the association between obesity and depression and the variation of this association as a function of years of education among a population-based sample of women aged 40–65 years. Methods A series of sample-weighted logistic regression models were used to estimate the associations between obesity, BID, and depression, stratified by educational attainment. Data were obtained from a structured telephone interview of 4543 female health plan enrollees, including self-reported height and weight, the Patient Health Questionnaire assessment of depression, and a single-item measure of BID. Results Among those with <16 years of education, in both the unadjusted and adjusted models, obesity and BID were significantly associated with depression. Similarly, among those with ≥16 years of education, obesity and BID were significantly associated with depression in the unadjusted models. However, in the adjusted model, only BID was associated with depression. A formal test for mediation suggests that the association between obesity and depression was mediated by BID regardless of level of education. Conclusions Our data suggest that BID-mediated the obesity-depression association. In addition, obesity and BID may be salient risk factors for depression among middle-aged women as a function of the level of education. PMID:21109045

Evolutionary Dynamics of Biological Auctions

PubMed Central

Chatterjee, Krishnendu; Reiter, Johannes G.; Nowak, Martin A.

2011-01-01

Many scenarios in the living world, where individual organisms compete for winning positions (or resources), have properties of auctions. Here we study the evolution of bids in biological auctions. For each auction n individuals are drawn at random from a population of size N. Each individual makes a bid which entails a cost. The winner obtains a benefit of a certain value. Costs and benefits are translated into reproductive success (fitness). Therefore, successful bidding strategies spread in the population. We compare two types of auctions. In “biological all-pay auctions” the costs are the bid for every participating individual. In “biological second price all-pay auctions” the cost for everyone other than the winner is the bid, but the cost for the winner is the second highest bid. Second price all-pay auctions are generalizations of the “war of attrition” introduced by Maynard Smith. We study evolutionary dynamics in both types of auctions. We calculate pairwise invasion plots and evolutionarily stable distributions over the continuous strategy space. We find that the average bid in second price all-pay auctions is higher than in all-pay auctions, but the average cost for the winner is similar in both auctions. In both cases the average bid is a declining function of the number of participants, n. The more individuals participate in an auction the smaller is the chance of winning, and thus expensive bids must be avoided. PMID:22120126

77 FR 33235 - Notice of Realty Action: Modified Competitive Sale of Public Lands in Becker County, MN

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... bid is received or the sale is cancelled. Sealed bid envelopes must be clearly marked on the front lower left-hand corner with ``SEALED BID BLM LAND SALE, MNES-056512''. The bid envelope must contain a... of Land Management. Personal checks will not be accepted. Failure to submit the remainder of the full...

46 CFR Sec. 4 - Procedure for securing competitive bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... not subject to the Davis-Bacon Act. (g) The Invitations for Bids shall also include a statement of the... Authority may orally contact as many qualified contractors as is feasible, in order to obtain written “Spot... contractor shall be verbally advised of a time and place for the submission of the “Spot Bids.” If such bids...

46 CFR Sec. 4 - Procedure for securing competitive bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... not subject to the Davis-Bacon Act. (g) The Invitations for Bids shall also include a statement of the... Authority may orally contact as many qualified contractors as is feasible, in order to obtain written “Spot... contractor shall be verbally advised of a time and place for the submission of the “Spot Bids.” If such bids...

46 CFR Sec. 4 - Procedure for securing competitive bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... not subject to the Davis-Bacon Act. (g) The Invitations for Bids shall also include a statement of the... Authority may orally contact as many qualified contractors as is feasible, in order to obtain written “Spot... contractor shall be verbally advised of a time and place for the submission of the “Spot Bids.” If such bids...

46 CFR Sec. 4 - Procedure for securing competitive bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... not subject to the Davis-Bacon Act. (g) The Invitations for Bids shall also include a statement of the... Authority may orally contact as many qualified contractors as is feasible, in order to obtain written “Spot... contractor shall be verbally advised of a time and place for the submission of the “Spot Bids.” If such bids...

46 CFR Sec. 4 - Procedure for securing competitive bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... not subject to the Davis-Bacon Act. (g) The Invitations for Bids shall also include a statement of the... Authority may orally contact as many qualified contractors as is feasible, in order to obtain written “Spot... contractor shall be verbally advised of a time and place for the submission of the “Spot Bids.” If such bids...

48 CFR 52.214-25 - Step Two of Two-Step Sealed Bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Step Two of Two-Step... Clauses 52.214-25 Step Two of Two-Step Sealed Bidding. As prescribed in 14.201-6(t), insert the following provision: Step Two of Two-Step Sealed Bidding (APR 1985) (a) This invitation for bids is issued to initiate...

78 FR 31616 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... current National Best Bid and National Best Offer, or if no National Best Bid or National Best Offer, at... the System to the Designated Percentage away from the then current National Best Bid and National Best Offer, or, if no National Best Bid or National Best Offer, to the Designated Percentage away from the...

Recreational benefits of urban forests: explaining visitors' willingness to pay in the context of the theory of planned behavior.

PubMed

Bernath, Katrin; Roschewitz, Anna

2008-11-01

The extension of contingent valuation models with an attitude-behavior based framework has been proposed in order to improve the descriptive and predictive ability of the models. This study examines the potential of the theory of planned behavior to explain willingness to pay (WTP) in a contingent valuation survey of the recreational benefits of the Zurich city forests. Two aspects of WTP responses, protest votes and bid levels, were analyzed separately. In both steps, models with and without the psychological predictors proposed by the theory of planned behavior were compared. Whereas the inclusion of the psychological predictors significantly improved explanations of protest votes, their ability to improve the performance of the model explaining bid levels was limited. The results indicate that the interpretation of bid levels as behavioral intention may not be appropriate and that the potential of the theory of planned behavior to improve contingent valuation models depends on which aspect of WTP responses is examined.

Observation of interaction between bid and 14-3-3 proteins by FRET in living cell during TNF-a-induced apoptosis

NASA Astrophysics Data System (ADS)

Wang, Jinjun; Chen, Tongsheng; Xing, Da; Wang, Fang

2005-01-01

Caspase8 is activated and cleaves Bid into two fragments when cells are exposed to death-inducing molecules such as tumor necrosis factor-α (TNF-α). Then the C-terminal fragment relocates from cytosol to mitochondria and promotes the release of cytochrome c, in the final cellular apoptosis is induced. Despite recent progress in the study of Bid during apoptosis induction, it remains unclear how C-terminal fragment of Bid cleaved moves to mitochondria and then induces the release of cytochrome c and so on. The 14-3-3 proteins are known to sequester certain pro-apoptotic members of Bcl-2 family. In order to further study the biological action of Bid during apoptosis, especially under physiological condition of living cell, the plasmids pBid-CFP and pYFP-14-3-3 were constructed. By the transient transfection of pBid-CFP and pYFP-14-3-3, the dynamic process of interaction of Bid and 14-3-3 protein in individual living cell during the apoptosis was primarily investigated with FRET (fluorescent resonance energy transfer) technique by the use of fluorescence microscopy.

The effect of business improvement districts on the incidence of violent crimes

PubMed Central

Golinelli, Daniela; Stokes, Robert J; Bluthenthal, Ricky

2010-01-01

Objective To examine whether business improvement districts (BID) contributed to greater than expected declines in the incidence of violent crimes in affected neighbourhoods. Method A Bayesian hierarchical model was used to assess the changes in the incidence of violent crimes between 1994 and 2005 and the implementation of 30 BID in Los Angeles neighbourhoods. Results The implementation of BID was associated with a 12% reduction in the incidence of robbery (95% posterior probability interval −2 to 24) and an 8% reduction in the total incidence of violent crimes (95% posterior probability interval −5 to 21). The strength of the effect of BID on robbery crimes varied by location. Conclusion These findings indicate that the implementation of BID can reduce the incidence of violent crimes likely to result in injury to individuals. The findings also indicate that the establishment of a BID by itself is not a panacea, and highlight the importance of targeting BID efforts to crime prevention interventions that reduce violence exposure associated with criminal behaviours. PMID:20587814

The effect of business improvement districts on the incidence of violent crimes.

PubMed

MacDonald, John; Golinelli, Daniela; Stokes, Robert J; Bluthenthal, Ricky

2010-10-01

To examine whether business improvement districts (BID) contributed to greater than expected declines in the incidence of violent crimes in affected neighbourhoods. A Bayesian hierarchical model was used to assess the changes in the incidence of violent crimes between 1994 and 2005 and the implementation of 30 BID in Los Angeles neighbourhoods. The implementation of BID was associated with a 12% reduction in the incidence of robbery (95% posterior probability interval -2 to 24) and an 8% reduction in the total incidence of violent crimes (95% posterior probability interval -5 to 21). The strength of the effect of BID on robbery crimes varied by location. These findings indicate that the implementation of BID can reduce the incidence of violent crimes likely to result in injury to individuals. The findings also indicate that the establishment of a BID by itself is not a panacea, and highlight the importance of targeting BID efforts to crime prevention interventions that reduce violence exposure associated with criminal behaviours.

Survey of findings in patients having persistent heartburn on proton pump inhibitor therapy.

PubMed

Mandaliya, R; DiMarino, A J; Cohen, S

2016-01-01

In patients with refractory heartburn while on proton pump inhibitor (PPI) therapy, changing drugs or increasing treatment to a twice a day (b.i.d.) dose has become a common practice. This study aims to study patients with persistent heartburn while on PPI therapy and to determine if persistent symptom indicates the need for more aggressive or different therapy. A retrospective review of impedance-pH tracings on PPI therapy (q.d. or b.i.d.) for patients with persistent heartburn was performed. DeMeester score, impedance, and symptom sensitive index (SSI) were used as indices. Statistical analyses were performed using chi-squared test with Yates correction and paired t-test. One hundred consecutive patients, (female 50%, male 50%, mean age 54 [range 16-83] years) were studied on q.d. (n = 45) or b.i.d. PPI (n = 55). Only 20% of the patients had abnormal DeMeester score; 41% had an abnormal impedance score and 56% had abnormal SSI; 29% had all indices normal. There was no difference between patients taking q.d. versus b.i.d. PPI for abnormal DeMeester score (22 vs. 18%), impedance (38 vs. 44%) and SSI (53 vs. 58%); P = 0.80, 0.69, and 0.77, respectively. In 56 patients with positive SSI, symptoms were due to acid reflux in 8 (14%) patients, nonacid reflux in 31 (55%) patients, and combined acid and nonacid reflux in 17 (30%) patients. Patients with persistent heartburn on PPI therapy show a variety of disorders: (i) acid reflux (20%); (ii) nonacid reflux (26%); (iii) positive SSI (56%); (iv) all normal indices (29%). These studies indicate that persistent heartburn on PPI therapy is a complex problem that may not respond to simply increasing acid inhibition. © 2014 International Society for Diseases of the Esophagus.

In defiance of the evidence: conservatives threaten to "reform" away England's National Health Service.

PubMed

Lister, John

2012-01-01

David Cameron's Conservative-led coalition government is pressing ahead with a highly controversial bill to "reform" the National Health Service (NHS), abolishing existing management structures, opening up provider services to private competition from "any qualified provider", and establishing a competitive market system in place of planning. The proposals fragment the structures and run counter to the founding principles of the NHS, which in 1948 transcended the limitations of markets, delivering health care on the basis of maximum risk sharing and universal access to services, free at the point of use. Evidence shows markets are a costly and inadequate mechanism to deliver universal and comprehensive health care, and private providers will only bid for services where profits are guaranteed. Opposition to the proposals is strong among health professionals and informed opinion, and the bill has divided the coalition parties--but time is running out for those who reject the bill to mount a sustained and concerted resistance.

Bidding process in online auctions and winning strategy: Rate equation approach

NASA Astrophysics Data System (ADS)

Yang, I.; Kahng, B.

2006-06-01

Online auctions have expanded rapidly over the last decade and have become a fascinating new type of business or commercial transaction in this digital era. Here we introduce a master equation for the bidding process that takes place in online auctions. We find that the number of distinct bidders who bid k times up to the t th bidding progresses, called the k -frequent bidder, seems to scale as nk(t)˜tk-2.4 . The successfully transmitted bidding rate by the k -frequent bidder is likely to scale as qk(t)˜k-1.4 , independent of t for large t . This theoretical prediction is close to empirical data. These results imply that bidding at the last moment is a rational and effective strategy to win in an eBay auction.

Robust guaranteed cost tracking control of quadrotor UAV with uncertainties.

PubMed

Xu, Zhiwei; Nian, Xiaohong; Wang, Haibo; Chen, Yinsheng

2017-07-01

In this paper, a robust guaranteed cost controller (RGCC) is proposed for quadrotor UAV system with uncertainties to address set-point tracking problem. A sufficient condition of the existence for RGCC is derived by Lyapunov stability theorem. The designed RGCC not only guarantees the whole closed-loop system asymptotically stable but also makes the quadratic performance level built for the closed-loop system have an upper bound irrespective to all admissible parameter uncertainties. Then, an optimal robust guaranteed cost controller is developed to minimize the upper bound of performance level. Simulation results verify the presented control algorithms possess small overshoot and short setting time, with which the quadrotor has ability to perform set-point tracking task well. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.

PubMed

Kinsella, Sinéad; Fichtner, Michael; Watters, Orla; König, Hans-Georg; Prehn, Jochen H M

2018-05-02

Chronic pro-inflammatory signaling propagates damage to neural tissue and affects the rate of disease progression. Increased activation of Toll-like receptors (TLRs), master regulators of the innate immune response, is implicated in the etiology of several neuropathologies including amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease. Previously, we identified that the Bcl-2 family protein BH3-interacting domain death agonist (Bid) potentiates the TLR4-NF-κB pro-inflammatory response in glia, and specifically characterized an interaction between Bid and TNF receptor associated factor 6 (TRAF6) in microglia in response to TLR4 activation. We assessed the activation of mitogen-activated protein kinase (MAPK) and interferon regulatory factor 3 (IRF3) inflammatory pathways in response to TLR3 and TLR4 agonists in wild-type (wt) and bid-deficient microglia and macrophages, using Western blot and qPCR, focusing on the response of the E3 ubiquitin ligases Pellino 1 (Peli1) and TRAF3 in the absence of microglial and astrocytic Bid. Additionally, by Western blot, we investigated the Bid-dependent turnover of Peli1 and TRAF3 in wt and bid -/- microglia using the proteasome inhibitor Bortezomib. Interactions between the de-ubiquitinating Smad6-A20 and the E3 ubiquitin ligases, TRAF3 and TRAF6, were determined by FLAG pull-down in TRAF6-FLAG or Smad6-FLAG overexpressing wt and bid-deficient mixed glia. We elucidated a positive role of Bid in both TIR-domain-containing adapter-inducing interferon-β (TRIF)- and myeloid differentiation primary response 88 (MyD88)-dependent pathways downstream of TLR4, concurrently implicating TLR3-induced inflammation. We identified that Peli1 mRNA levels were significantly reduced in PolyI:C- and lipopolysaccharide (LPS)-stimulated bid-deficient microglia, suggesting disturbed IRF3 activation. Differential regulation of TRAF3 and Peli1, both essential E3 ubiquitin ligases facilitating TRIF-dependent signaling, was observed between wt and bid -/- microglia and astrocytes. bid deficiency resulted in increased A20-E3 ubiquitin ligase protein interactions in glia, specifically A20-TRAF6 and A20-TRAF3, implicating enhanced de-ubiquitination as the mechanism of action by which E3 ligase activity is perturbed. Furthermore, Smad6-facilitated recruitment of the de-ubiquitinase A20 to E3-ligases occurred in a bid-dependent manner. This study demonstrates that Bid promotes E3 ubiquitin ligase-mediated signaling downstream of TLR3 and TLR4 and provides further evidence for the potential of Bid inhibition as a therapeutic for the attenuation of the robust pro-inflammatory response culminating in TLR activation.

Procurement and Contracting, Transportation & Public Facilities, State of

Science.gov Websites

Calendar Bid Opening Results Contract Award Status AASHTOWare Project Vendor List Contractor Bidding List Contractor Bidding Information Requests for Proposals Professional Services Request for Proposals

24 CFR 968.135 - Contracting requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... indicated by poor performance, a PHA may be required to submit to HUD periodic progress reports and, for... to 5% of the bid price; and one of the following: (1) A performance and payment bond for 100 percent of the contract price; or (2) Separate performance and payment bonds, each for 50% or more of the...

Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Bao-guang; Department of Gastrointestinal Surgery, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong; Liu, Li-ping

SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producingmore » cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo.« less

Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet.

PubMed

Raskin, P; Lewin, A; Reinhardt, R; Lyness, W

2009-09-01

To assess the use of a new repaglinide/metformin fixed-dose combination (FDC) tablet for the treatment of type 2 diabetes. In this 26-week, multicentre, open-label, parallel-group trial, subjects poorly controlled with mono- or dual-oral antidiabetic therapy were randomized 1 : 1 : 1 to receive a repaglinide/metformin FDC tablet either two times daily (BID) or three times daily (TID) or a rosiglitazone/metformin FDC tablet BID. The primary objective comprised two hypotheses tested in a hierarchical order: (i) that treatment with the repaglinide/metformin FDC BID is non-inferior to that of a rosiglitazone/metformin FDC tablet BID as measured by changes in haemoglobin A1c (HbA1c) (results presented here) and (ii) if true, that treatment with the repaglinide/metformin FDC BID was non-inferior to that of the repaglinide/metformin FDC TID as measured by changes in HbA1c (results presented in a companion paper). Additional efficacy and safety end-points were also assessed. Of the 561 subjects randomized, 383 completed the study. Reductions in HbA1c values became apparent at earlier times for repaglinide/metformin FDC BID treatment than rosiglitazone/metformin FDC BID, and final changes in HbA1c were not significantly different between treatment arms (p = 0.8186); thus, the predefined statistical criterion for non-inferiority was met. Overall adverse event profiles were comparable between treatment groups, and no major hypoglycaemic episodes were reported during the study. The repaglinide/metformin FDC BID regimen showed efficacy that was non-inferior to that of the rosiglitazone/metformin FDC BID regimen currently in clinical use and a more rapid reduction of HbA1c values. Thus, repaglinide/metformin FDC BID is a clinically feasible alternative to rosiglitazone/metformin FDC BID.

47 CFR 22.228 - Cellular rural service area licenses subject to competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Licensing Requirements and Procedures Competitive Bidding... initial applications for Cellular Rural Service Area licenses are subject to competitive bidding. The...

Human islet cells are killed by BID-independent mechanisms in response to FAS ligand.

PubMed

Joglekar, Mugdha V; Trivedi, Prerak M; Kay, Thomas W; Hawthorne, Wayne J; O'Connell, Philip J; Jenkins, Alicia J; Hardikar, Anandwardhan A; Thomas, Helen E

2016-04-01

Cell death via FAS/CD95 can occur either by activation of caspases alone (extrinsic) or by activation of mitochondrial death signalling (intrinsic) depending on the cell type. The BH3-only protein BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways. We have previously demonstrated that islets from BID-deficient mice are protected from FAS ligand-mediated apoptosis in vitro. However, it is not yet known if BID plays a similar role in human beta cell death. We therefore aimed to test the role of BID in human islet cell apoptosis immediately after isolation from human cadaver donors, as well as after de-differentiation in vitro. Freshly isolated human islets or 10-12 day cultured human islet cells exhibited BID transcript knockdown after BID siRNA transfection, however they were not protected from FAS ligand-mediated cell death in vitro as determined by DNA fragmentation analysis using flow cytometry. On the other hand, the same cells transfected with siRNA for FAS-associated via death domain (FADD), a molecule in the extrinsic cell death pathway upstream of BID, showed significant reduction in cell death. De-differentiated islets (human islet-derived progenitor cells) also demonstrated similar results with no difference in cell death after BID knockdown as compared to scramble siRNA transfections. Our results indicate that BID-independent pathways are responsible for FAS-dependent human islet cell death. These results are different from those observed in mouse islets and therefore demonstrate potentially alternate pathways of FAS ligand-induced cell death in human and mouse islet cells.

36 CFR 18.7 - How are lease proposals solicited and selected if the Director issues a Request for Bids?

Code of Federal Regulations, 2010 CFR

2010-07-01

... solicited and selected if the Director issues a Request for Bids? 18.7 Section 18.7 Parks, Forests, and... § 18.7 How are lease proposals solicited and selected if the Director issues a Request for Bids? (a) If the amount of the rent is the only criterion for award of a lease, the Director may solicit bids...

BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

PubMed Central

Martin, Nellie Anne; Bonner, Helena; Elkjær, Maria Louise; D’Orsi, Beatrice; Chen, Gang; König, Hans Georg; Svensson, Martina; Deierborg, Tomas; Pfeiffer, Shona; Prehn, Jochen H.; Lambertsen, Kate Lykke

2016-01-01

The BH3 interacting-domain death agonist (BID) is a pro-apoptotic protein involved in death receptor-induced and mitochondria-mediated apoptosis. Recently, it has also been suggested that BID is involved in the regulation of inflammatory responses in the central nervous system. We found that BID deficiency protected organotypic hippocampal slice cultures in vitro from neuronal injury induced by oxygen-glucose deprivation. In vivo, BID-knockout (KO) mice and wild type (WT) mice were subjected to 60 min of transient middle cerebral artery occlusion (tMCAO) to induce focal cerebral ischemia, and allowed to recover for 24 h. Infarct volumes and functional outcome were assessed and the inflammatory response was evaluated using immunofluorescence, Western blotting, quantitative PCR (qPCR) and Mesoscale multiplex analysis. We observed no difference in the infarct volume or neurological outcome between BID-KO and WT mice. The inflammatory response was reduced by BID deficiency as indicated by a change in microglial/leukocyte response. In conclusion, our data suggest that BID deficiency is neuroprotective in an in vitro model and modulates the inflammatory response to focal cerebral ischemia in vivo. However, this is not translated into a robust neuroprotection in vivo. PMID:26869884

A Robust Open Ascending-price Multi-unit Auction Protocol against False-name Bids

NASA Astrophysics Data System (ADS)

Iwasaki, Atsushi; Yokoo, Makoto; Terada, Kenji

This paper develops a new ascending-price multi-unit auction protocol that has following characteristics: (i) it has an open format, (ii) sincere bidding is an equilibrium strategy even if the marginal utilities of each agent can increase and agents can submit false-name bids. False-name bids are bids submitted under fictitious names such as multiple e-mail addresses, which can be done easily in the Internet. This is the first protocol that has these two characteristics. We show that our new protocol outperforms an existing protocol, which satisfies (ii), with respect to the social surplus and the seller's revenue.

Alternative contracting research : [project summary].

DOT National Transportation Integrated Search

2016-09-01

To conserve taxpayer money, many governmental agencies use a low-bid process for design : and construction services. The Florida Department of Transportations (FDOT) Design-Bid-Build : process falls in this category. However, a low-bid approach do...

Alternative pavement designs : Randolph park and ride.

DOT National Transportation Integrated Search

2013-05-01

Previous research on alternative pavement type bidding has proven that various treatments : are unique in terms of constructability, material characteristics, and associated performance. : While some treatments may have higher initial costs, it is im...

Welfare Impact of Virtual Trading on Wholesale Electricity Markets

NASA Astrophysics Data System (ADS)

Giraldo, Juan S.

Virtual bidding has become a standard feature of multi-settlement wholesale electricity markets in the United States. Virtual bids are financial instruments that allow market participants to take financial positions in the Day-Ahead (DA) market that are automatically reversed/closed in the Real-Time (RT) market. Most U.S. wholesale electricity markets only have two types of virtual bids: a decrement bid (DEC), which is virtual load, and an increment offer (INC), which is virtual generation. In theory, financial participants create benefits by seeking out profitable bidding opportunities through arbitrage or speculation. Benefits have been argued to take the form of increased competition, price convergence, increased market liquidity, and a more efficient dispatch of generation resources. Studies have found that price convergence between the DA and RT markets improved following the introduction of virtual bidding into wholesale electricity markets. The improvement in price convergence was taken as evidence that market efficiency had increased and many of the theoretical benefits realized. Persistent price differences between the DA and RT markets have led to calls to further expand virtual bidding as a means to address remaining market inefficiencies. However, the argument that price convergence is beneficial is extrapolated from the study of commodity and financial markets and the role of futures for increasing market efficiency in that context. This viewpoint largely ignores details that differentiate wholesale electricity markets from other commodity markets. This dissertation advances the understanding of virtual bidding by evaluating the impact of virtual bidding based on the standard definition of economic efficiency which is social welfare. In addition, an examination of the impacts of another type of virtual bid, up-to-congestion (UTC) transactions is presented. This virtual product significantly increased virtual bidding activity in the PJM interconnection market since it became available to be used by financial traders in September 2010. Stylized models are used to determine the optimal bidding strategy for the different virtual bids under different scenarios. The welfare analysis shows that the main impact of virtual bidding is surplus reallocation and that the impact on market efficiency is small by comparison. The market structure is such that it is more likely to see surplus transfers from consumers to producers. The results also show that outcomes with greater price convergence as a result of virtual bidding activity were not necessarily more efficient, nor do they always correct surplus distribution distortions that result from bias in the DA expectation of RT load. Compared to INCs and DECs, the UTC analysis showed that UTCs do not have the same self-corrective incentives towards price convergence and are less likely to lead to nodal price convergence or correct for surplus distribution distortions caused by uncertainty and bias in the DA expectation of RT load. Additionally, the analysis showed that UTCs allow financial traders to engage in low risk high volume trading strategies that, while profitable, may have little to no impact on price convergence or market efficiency.

41 CFR 102-38.225 - What are the additional requirements in the bid process?

Code of Federal Regulations, 2010 CFR

2010-07-01

... bid process? All sales except fixed price sales must contain a certification of independent price... matter to the Department of Justice or your agency's Office of the Inspector General. Bid Deposits ...

48 CFR 14.304 - Submission, modification, and withdrawal of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... transmitted bid, the data received must not be viewed and, where practicable, must be purged from primary and backup data storage systems. (f) The contracting officer must promptly notify any bidder if its bid...

48 CFR 14.304 - Submission, modification, and withdrawal of bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... transmitted bid, the data received must not be viewed and, where practicable, must be purged from primary and backup data storage systems. (f) The contracting officer must promptly notify any bidder if its bid...

48 CFR 14.303 - Modification or withdrawal of bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... for the bid. (c) Upon withdrawal of an electronically transmitted bid, the data received shall not be viewed and shall be purged from primary and backup data storage systems. [48 FR 42171, Sept. 19, 1983, as...

48 CFR 14.303 - Modification or withdrawal of bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... for the bid. (c) Upon withdrawal of an electronically transmitted bid, the data received shall not be viewed and shall be purged from primary and backup data storage systems. [48 FR 42171, Sept. 19, 1983, as...

48 CFR 14.304 - Submission, modification, and withdrawal of bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... transmitted bid, the data received must not be viewed and, where practicable, must be purged from primary and backup data storage systems. (f) The contracting officer must promptly notify any bidder if its bid...

48 CFR 14.304 - Submission, modification, and withdrawal of bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... transmitted bid, the data received must not be viewed and, where practicable, must be purged from primary and backup data storage systems. (f) The contracting officer must promptly notify any bidder if its bid...

48 CFR 14.304 - Submission, modification, and withdrawal of bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... transmitted bid, the data received must not be viewed and, where practicable, must be purged from primary and backup data storage systems. (f) The contracting officer must promptly notify any bidder if its bid...

48 CFR 14.303 - Modification or withdrawal of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for the bid. (c) Upon withdrawal of an electronically transmitted bid, the data received shall not be viewed and shall be purged from primary and backup data storage systems. [48 FR 42171, Sept. 19, 1983, as...

48 CFR 14.303 - Modification or withdrawal of bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... for the bid. (c) Upon withdrawal of an electronically transmitted bid, the data received shall not be viewed and shall be purged from primary and backup data storage systems. [48 FR 42171, Sept. 19, 1983, as...

48 CFR 14.303 - Modification or withdrawal of bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for the bid. (c) Upon withdrawal of an electronically transmitted bid, the data received shall not be viewed and shall be purged from primary and backup data storage systems. [48 FR 42171, Sept. 19, 1983, as...

Advertising and Sealed Bid Auctions in a Transshipment Game

DTIC Science & Technology

1996-06-01

distributors promote their sales by advertising . While the maximum quantity demanded by each customer is fixed and given, his bids on the various...brands are determined by the advertising and other promotional efforts. The bid response function for each consumer is supposed to be given and known. The...the optimal distribution of the product, and the bids of the consumers . A numerical example is provided and the solution routine is discussed.

Smarter than others? Conjectures in lowest unique bid auctions.

PubMed

Zhou, Cancan; Dong, Hongguang; Hu, Rui; Chen, Qinghua

2015-01-01

Research concerning various types of auctions, such as English auctions, Dutch auctions, highest-price sealed-bid auctions, and second-price sealed-bid auctions, is always a topic of considerable interest in interdisciplinary fields. The type of auction, known as a lowest unique bid auction (LUBA), has also attracted significant attention. Various models have been proposed, but they often fail to explain satisfactorily the real bid-distribution characteristics. This paper discusses LUBA bid-distribution characteristics, including the inverted-J shape and the exponential decrease in the upper region. The authors note that this type of distribution, which initially increases and later decreases, cannot be derived from the symmetric Nash equilibrium framework based on perfect information that has previously been used. A novel optimization model based on non-perfect information is presented. The kernel of this model is the premise that agents make decisions to achieve maximum profit based on imaginary information or assumptions regarding the behavior of others.

Minimizing forced outage risk in generator bidding

NASA Astrophysics Data System (ADS)

Das, Dibyendu

Competition in power markets has exposed the participating companies to physical and financial uncertainties. Generator companies bid to supply power in a day-ahead market. Once their bids are accepted by the ISO they are bound to supply power. A random outage after acceptance of bids forces a generator to buy power from the expensive real-time hourly spot market and sell to the ISO at the set day-ahead market clearing price, incurring losses. A risk management technique is developed to assess this financial risk associated with forced outages of generators and then minimize it. This work presents a risk assessment module which measures the financial risk of generators bidding in an open market for different bidding scenarios. The day-ahead power market auction is modeled using a Unit Commitment algorithm and a combination of Normal and Cauchy distributions generate the real time hourly spot market. Risk profiles are derived and VaRs are calculated at 98 percent confidence level as a measure of financial risk. Risk Profiles and VaRs help the generators to analyze the forced outage risk and different factors affecting it. The VaRs and the estimated total earning for different bidding scenarios are used to develop a risk minimization module. This module will develop a bidding strategy of the generator company such that its estimated total earning is maximized keeping the VaR below a tolerable limit. This general framework of a risk management technique for the generating companies bidding in competitive day-ahead market can also help them in decisions related to building new generators.

Hybrid promoters directed tBid gene expression to breast cancer cells by transcriptional targeting.

PubMed

Farokhimanesh, Samila; Rahbarizadeh, Fatemeh; Rasaee, Mohammad J; Kamali, Abbas; Mashkani, Baratali

2010-01-01

Developing cancer gene therapy constructs based on transcriptional targeting of genes to cancer cells is a new and promising modality for treatment of cancer. Introducing truncated Bid (tBid), a recently known member of the Bcl-2 family, eradicates cancer cells efficiently. For transcriptional targeting of tBid, two dual-specificity promoters, combining cancer specific core promoters and response modules, were designed. These two core promoter modules contained cancer specific promoters of MUC1 and Survivin genes accompanied by hypoxia-responsive elements and estrogen responsive elements (microenvironment condition of breast cancer cells) which were employed to achieve a higher and more specific level of tBid expression in breast cancer cells. Correlation of the level of tBid expression in normal and cancer cell lines with promoter activity was measured by RT-PCR after treatment with hypoxia and estrogen. The level of tBid expression under control of new hybrid promoters was compared with its expression under control of cytomegalovirus (CMV) promoter as a control. Our data revealed that the level of tBid expression in breast cancer cells were nearly 11 times more than normal cells because of the cancer specific promoters, although tBid expression under control of CMV promoter was almost the same in normal and cancer cell lines. Increased apoptosis was detected in the transfected breast cancer cell lines by the Caspase-3 activity assay. The application of these promoters may prove to have the advantage of tumor selective gene therapy in breast cancer cells and low-potential toxicity for normal tissues.

Optimal generator bidding strategies for power and ancillary services

NASA Astrophysics Data System (ADS)

Morinec, Allen G.

As the electric power industry transitions to a deregulated market, power transactions are made upon price rather than cost. Generator companies are interested in maximizing their profits rather than overall system efficiency. A method to equitably compensate generation providers for real power, and ancillary services such as reactive power and spinning reserve, will ensure a competitive market with an adequate number of suppliers. Optimizing the generation product mix during bidding is necessary to maximize a generator company's profits. The objective of this research work is to determine and formulate appropriate optimal bidding strategies for a generation company in both the energy and ancillary services markets. These strategies should incorporate the capability curves of their generators as constraints to define the optimal product mix and price offered in the day-ahead and real time spot markets. In order to achieve such a goal, a two-player model was composed to simulate market auctions for power generation. A dynamic game methodology was developed to identify Nash Equilibria and Mixed-Strategy Nash Equilibria solutions as optimal generation bidding strategies for two-player non-cooperative variable-sum matrix games with incomplete information. These games integrated the generation product mix of real power, reactive power, and spinning reserve with the generators's capability curves as constraints. The research includes simulations of market auctions, where strategies were tested for generators with different unit constraints, costs, types of competitors, strategies, and demand levels. Studies on the capability of large hydrogen cooled synchronous generators were utilized to derive useful equations that define the exact shape of the capability curve from the intersections of the arcs defined by the centers and radial vectors of the rotor, stator, and steady-state stability limits. The available reactive reserve and spinning reserve were calculated given a generator operating point in the P-Q plane. Four computer programs were developed to automatically perform the market auction simulations using the equal incremental cost rule. The software calculates the payoffs for the two competing competitors, dispatches six generators, and allocates ancillary services for 64 combinations of bidding strategies, three levels of system demand, and three different types of competitors. Matrix Game theory was utilized to calculate Nash Equilibrium solutions and mixed-strategy Nash solutions as the optimal generator bidding strategies. A method to incorporate ancillary services into the generation bidding strategy, to assure an adequate supply of ancillary services, and to allocate these necessary resources to the on-line units was devised. The optimal generator bid strategy in a power auction was shown to be the Nash Equilibrium solution found in two-player variable-sum matrix games.

48 CFR 614.402-70 - Waiver of public opening of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of public opening of bids. Overseas posts may request waiver of the public opening of bids if that activity is inconsistent with local law or legal practice, or with post security. For that purpose, the...

47 CFR 90.910 - Bidding credits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... cost of its winning bid on Spectrum Blocks A through V. A winning bidder that qualifies as a small... percent to lower the cost of its winning bid on Spectrum Blocks A through V. [68 FR 43001, July 21, 2003] ...

47 CFR 90.910 - Bidding credits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... cost of its winning bid on Spectrum Blocks A through V. A winning bidder that qualifies as a small... percent to lower the cost of its winning bid on Spectrum Blocks A through V. [68 FR 43001, July 21, 2003] ...

47 CFR 90.910 - Bidding credits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... cost of its winning bid on Spectrum Blocks A through V. A winning bidder that qualifies as a small... percent to lower the cost of its winning bid on Spectrum Blocks A through V. [68 FR 43001, July 21, 2003] ...

47 CFR 90.910 - Bidding credits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... cost of its winning bid on Spectrum Blocks A through V. A winning bidder that qualifies as a small... percent to lower the cost of its winning bid on Spectrum Blocks A through V. [68 FR 43001, July 21, 2003] ...

24 CFR 891.535 - Requirements for awarding construction contracts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... be an opportunity for minority owned and women owned businesses to be awarded a contract. (1) Bids... the right to reject any or all bids and to waive any informality. (3) The bid form, which must be...

48 CFR 32.304-3 - Asset formula.

Code of Federal Regulations, 2010 CFR

2010-10-01

... extent for the time actually necessary for contract performance, if the contractor's working capital and... guaranteed loans made primarily for working capital purposes, the agency shall normally limit the guarantee... entitled to payment on performance or termination. The formula shall exclude— (1) Amounts for which the...

Expert Meeting Report: Energy Savings You Can Bank On

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beman, M.; Springer, J.; Smith, P.

In October 2011, ARBI organized and conducted an Experts' Meeting on the topic of performance guarantees and financing vehicles for Energy Efficiency Upgrades. The meeting brought together technical, policy, and financial experts, including researchers, experienced installation contractors, and innovative energy business leaders, in order to discuss the opportunities and challenges for the energy efficiency upgrade industry to increase market uptake of Home Energy Upgrades (HEUs) through innovative offerings, such as performance guarantees. The meeting had several primary goals. First, it sought to understand how other industries have developed successful models for financing renewable energy installations while providing performance guarantees. Thismore » has been most recently demonstrated by the solar leasing industry. Second, the meeting explored the applicability of such business models to the energy efficiency upgrade industry. Third, the meeting sought to identify technical impediments to performance guarantees for energy efficiency retrofits. Fourth, the meeting sought to provide a common framework for these goals within the context of current financing mechanisms for energy efficiency upgrades.« less

Myths, Misconceptions, and Realities about Public Procurement Automation.

ERIC Educational Resources Information Center

Bonner, Larry

1989-01-01

Meaningful public procurement and inventory management automation encompasses all purchasing and materials management processes, including bidder selection; bidder responsiveness tracking; preparation of bid solicitations; bid tabulation; the tracking of requisitions, bid solicitations, and deliveries; and item purchasing history reports. (MLH)

43 CFR 2710.0-6 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of public lands under this section shall be conducted under competitive bidding procedures... competitive bidding or without competitive bidding. In recognizing public policies, the Secretary shall give... considered in determining the method of sale. These factors include, but are not limited to: Competitive...

47 CFR 90.1021 - Definitions concerning competitive bidding process.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Definitions concerning competitive bidding process. 90.1021 Section 90.1021 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY... 220 MHz Service § 90.1021 Definitions concerning competitive bidding process. (a) Scope. The...

48 CFR 245.7304 - Informal bid procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Inventory 245.7304 Informal bid procedures. (a) Upon approval of the plant clearance officer, the contractor...— (1) Maximum practical competition is maintained; (2) Sources solicited are recorded; and (3) Informal... plant clearance officer prior to soliciting bids from other prospective bidders. ...

The effects of exenatide twice daily compared to insulin lispro added to basal insulin in Latin American patients with type 2 diabetes: A retrospective analysis of the 4B trial.

PubMed

de Lapertosa, Silvia Beatriz Gorban; Frechtel, Gustavo; Hardy, Elise; Sauque-Reyna, Leobardo

2016-12-01

Socioeconomic changes in Latin American countries have led to an increased prevalence of type 2 diabetes (T2D). We examined the effects of exenatide twice daily (BID) or insulin lispro, each added to insulin glargine, in Latin American patients with T2D. This was a subgroup analysis of patients from Argentina and Mexico in the 4B study (N=114). Patients with glycated hemoglobin (HbA1c) of 7.0-10.0% (53-86mmol/mol) after 12weeks of intensive basal insulin optimization were randomized to exenatide BID or thrice-daily insulin lispro added to insulin glargine and metformin. After 30weeks, addition of exenatide BID or insulin lispro resulted in significant (P<0.0001) reductions in HbA1c (exenatide BID: -0.9% [-10mmol/mol]; insulin lispro: -1.2% [-13mmol/mol]). Weight was stable in the exenatide BID group (-0.1kg) and increased significantly (+3.4kg; P<0.0001) with insulin lispro. Major and minor hypoglycemia occurred less frequently (40 vs. 253 events) with exenatide BID compared with insulin lispro. Gastrointestinal adverse events of nausea, diarrhea, and vomiting occurred more frequently with exenatide BID than with insulin lispro. Both exenatide BID and prandial insulin lispro, each added to basal insulin glargine, were effective at reducing HbA1c in Latin American patients. Treatment with exenatide BID resulted in stable weight but more gastrointestinal adverse events. Treatment with insulin lispro resulted in weight gain and an increased risk of hypoglycemia. These findings support the addition of exenatide BID to insulin glargine as an option for Latin American patients unable to achieve glycemic control on basal insulin alone. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium.

PubMed

Driak, D; Dvorska, M; Bolehovska, P; Svandova, I; Novotny, J; Halaska, M

2014-01-01

The most common malignancies of the female genital tract are endometrial carcinomas, whose are generally proceeded by hyperplasia. The maintenance of tissue homeostasis is to great extent governed by apoptosis, whose defects can lead to the preneoplastic and/or cancerous changes. Endometrial apoptosis involves among others three groups of proteins of the Bcl-2 family. First group contains anti-apoptotic proteins (e. g. Bcl-2, Bcl-xL). The other two groups belong to the pro-apoptotic proteins with three (e. g. Bax, Bak) or one (e. g. Bad, Bid) so-called BH domains. Bad and Bid trigger the oligomerization of Bak and Bax protein, which permeabilize the outer mitochondrial wall. Unlike Bid, Bad cannot directly trigger apoptosis. Instead, Bad lowers the threshold at which apoptosis is induced, by binding anti-apoptotic Bcl-2 proteins. However, their mutual counterbalance or synergism in the human endometrium has not been reported yet.In this study, the levels of Bid and Bad were measured using SDS-PAGE and Western blotting with specific antibodies, with the aim to analyse expression of Bid and Bad proteins in normal (NE), hyperplastic (HE) and cancerous (CE) endometrium. We demonstrated that Bid expression in CE reached only 47% and 50% of this observed in NE and HE. Conversely, Bad expression in HE reached only 40% and 36% of this observed in NE and CE, respectively. We detected no significant changes of Bid expression between HE and NE, and levels of Bad protein were not different between CE and NE.Trend of Bid and Bad protein expression is clearly opposite in HE and CE. We hypothesise that disrupted apoptotic program in CE seems to be reduced further by lowering levels of direct apoptotic trigger protein Bid. We suggest that the adenocarcinoma tissue of human endometrium thus tries to strengthen its apoptotic effort by lowering the apoptotic threshold via higher Bad levels.

[Body image dissatisfaction as a mediator of the association between BMI, self-esteem and mental health in early adolescents: a multiple-group path analysis across gender].

PubMed

Jang, Mi Heui; Lee, Gyungjoo

2013-04-01

This study was done to examine not only the relationships between body mass index (BMI), self-esteem, body image dissatisfaction (BID) and mental health, according to gender, but the mediating role of BID on mental health in relation to BMI and self-esteem among early adolescents. Data from 576 (296 boys and 280 girls) elementary school students in grades 5 to 6 were collected. A multiple-group path analysis was utilized to examine the relationships between BMI, self-esteem, BID and mental health by gender. In the path analysis for all students, poor mental health was related directly to BID, while it was indirectly related to BMI and self-esteem. In the multiple-group path analysis of both genders, BID was found to have a significant direct and indirect effect on mental health for girls alone. The findings suggested that BID should be examined early to prevent poor mental health in early adolescent girls. This study helps to elucidate the role of early adolescent BID on mental health and provides insight for further prevention and intervention programs in school and community mental health settings.

Switch from type II to I Fas/CD95 death signaling upon in vitro culturing of primary hepatocytes

PubMed Central

Walter, Dorothée; Schmich, Kathrin; Vogel, Sandra; Pick, Robert; Kaufmann, Thomas; Hochmuth, Florian Christoph; Haber, Angelika; Neubert, Karin; McNelly, Sabine; von Weizsäcker, Fritz; Merfort, Irmgard; Maurer, Ulrich; Strasser, Andreas; Borner, Christoph

2010-01-01

Fas/CD95-induced apoptosis of hepatocytes in vivo proceeds through the so-called type II pathway, requiring the pro-apoptotic BH3-only Bcl-2 family member Bid for mitochondrial death signaling. Consequently, Bid-deficient mice are protected from anti-Fas antibody injection induced fatal hepatitis. Here we report the unexpected finding that freshly isolated mouse hepatocytes, cultured on collagen or Matrigel™, become independent of Bid for Fas-induced apoptosis, thereby switching death signaling from type II to type I. In such in vitro cultures, FasL activates caspase-3 without Bid cleavage, Bax/Bak activation or cytochrome c release, and neither Bid ablation nor Bcl-2 overexpression is protective. The type II to type I switch depends on extracellular matrix adhesion, as primary hepatocytes in suspension die in a Bid-dependent manner. Moreover, the switch is specific for FasL-induced apoptosis as collagen-plated Bid-deficient hepatocytes are protected from TNFα/ActD-induced apoptosis. Conclusion Our data suggest a selective crosstalk between extracellular matrix and Fas-mediated signaling which favours mitochondria-independent type I apoptosis induction. PMID:19003879

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes.

PubMed

Walter, Dorothée; Schmich, Kathrin; Vogel, Sandra; Pick, Robert; Kaufmann, Thomas; Hochmuth, Florian Christoph; Haber, Angelika; Neubert, Karin; McNelly, Sabine; von Weizsäcker, Fritz; Merfort, Irmgard; Maurer, Ulrich; Strasser, Andreas; Borner, Christoph

2008-12-01

Fas/CD95-induced apoptosis of hepatocytes in vivo proceeds through the so-called type II pathway, requiring the proapoptotic BH3-only Bcl-2 family member Bid for mitochondrial death signaling. Consequently, Bid-deficient mice are protected from anti-Fas antibody injection induced fatal hepatitis. We report the unexpected finding that freshly isolated mouse hepatocytes, cultured on collagen or Matrigel, become independent of Bid for Fas-induced apoptosis, thereby switching death signaling from type II to type I. In such in vitro cultures, Fas ligand (FasL) activates caspase-3 without Bid cleavage, Bax/Bak activation or cytochrome c release, and neither Bid ablation nor Bcl-2 overexpression is protective. The type II to type I switch depends on extracellular matrix adhesion, as primary hepatocytes in suspension die in a Bid-dependent manner. Moreover, the switch is specific for FasL-induced apoptosis as collagen-plated Bid-deficient hepatocytes are protected from tumor necrosis factor alpha/actinomycin D (TNFalpha/ActD)-induced apoptosis. Our data suggest a selective crosstalk between extracellular matrix and Fas-mediated signaling that favors mitochondria-independent type I apoptosis induction.

[Brain activitivation of euthymic patients with Type I bipolar disorder in resting state Default Mode Network].

PubMed

Vargas, Cristian; Pineda, Julián; Calvo, Víctor; López-Jaramillo, Carlos

2014-01-01

As there are still doubts about brain connectivity in type I bipolar disorder (BID), resting-state functional magnetic resonance imaging (RS-fMRI) studies are necessary during euthymia for a better control of confounding factors. To evaluate the differences in brain activation between euthymic BID patients and control subjects using resting state- functional-magnetic resonance imaging (RS-fMRI), and to identify the lithium effect in these activations. A cross-sectional study was conducted on 21 BID patients (10 receiving lithium only, and 11 non-medicated) and 12 healthy control subjects, using RS fMRI and independent component analysis (ICA). Increased activation was found in the right hippocampus (P=.049) and posterior cingulate (P=.040) within the Default Mode Network (DMN) when BID and control group were compared. No statistically significant differences were identified between BID on lithium only therapy and non-medicated BID patients. The results suggest that there are changes in brain activation and connectivity in BID even during euthymic phase and mainly within the DMN network, which could be relevant in affect regulation. Copyright © 2013 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

Estimating procedure for major highway construction bid item cost : final report.

DOT National Transportation Integrated Search

1978-06-01

The present procedure for estimating construction bid item cost makes use of the quarterly weighted average unit price report coupled with engineering judgement. The limitation to this method is that this report format provides only the lowest bid da...

42 CFR 414.422 - Terms of contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) MEDICARE PROGRAM PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Competitive Bidding for Certain... exercised by CMS, for the full duration of the contract period. (b) Recompeting competitive bidding contracts. CMS recompetes competitive bidding contracts at least once every 3 years. (c) Nondiscrimination...

42 CFR 414.422 - Terms of contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) MEDICARE PROGRAM PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Competitive Bidding for Certain... exercised by CMS, for the full duration of the contract period. (b) Recompeting competitive bidding contracts. CMS recompetes competitive bidding contracts at least once every 3 years. (c) Nondiscrimination...

7 CFR 1726.201 - Formal competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Procurement Procedures § 1726.201 Formal... formal competitive bidding: (a) Selection of qualified bidders. The borrower (acting through its engineer... § 1726.23). (b) Invitations to bid. The borrower (acting through its engineer, if applicable) is...

7 CFR 1726.201 - Formal competitive bidding.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Procurement Procedures § 1726.201 Formal... formal competitive bidding: (a) Selection of qualified bidders. The borrower (acting through its engineer... § 1726.23). (b) Invitations to bid. The borrower (acting through its engineer, if applicable) is...

7 CFR 1726.201 - Formal competitive bidding.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Procurement Procedures § 1726.201 Formal... formal competitive bidding: (a) Selection of qualified bidders. The borrower (acting through its engineer... § 1726.23). (b) Invitations to bid. The borrower (acting through its engineer, if applicable) is...

7 CFR 1726.201 - Formal competitive bidding.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Procurement Procedures § 1726.201 Formal... formal competitive bidding: (a) Selection of qualified bidders. The borrower (acting through its engineer... § 1726.23). (b) Invitations to bid. The borrower (acting through its engineer, if applicable) is...

7 CFR 1726.201 - Formal competitive bidding.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Procurement Procedures § 1726.201 Formal... formal competitive bidding: (a) Selection of qualified bidders. The borrower (acting through its engineer... § 1726.23). (b) Invitations to bid. The borrower (acting through its engineer, if applicable) is...

47 CFR 1.2203 - Competitive bidding mechanisms.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Random Selection Competitive Bidding Proceedings Broadcast Television Spectrum Reverse Auction § 1.2203... forward auction assigning new spectrum licenses will occur. (2) Reserve price. Reserve prices, either... winning bid. A winning bidder will relinquish spectrum usage rights pursuant to the terms of any winning...

Bidding: Getting the Best Price for School Foodservice.

ERIC Educational Resources Information Center

DiBella, Cecilia M.

1998-01-01

Sharon (Massachusetts) Public Schools developed an alternative procurement process for school food services that complies with state public bidding laws while evading "low-bid" constraints. The new process features evaluative criteria covering nutrition education, community outreach, management expertise, site visits, and price…

But I'm an engineer—not a contracts lawyer!

NASA Astrophysics Data System (ADS)

Warner, Mark; Bass, Harvey

2012-09-01

Industrial partners, commercial vendors, and subsystem contractors play a large role in the design and construction of modern telescopes. Because many telescope projects carry relatively small staffs, engineers are often required to perform the additional functions of technical writing, cost estimating, and contract bidding and negotiating. The skills required to carry out these tasks are not normally taught in traditional engineering programs. As a result, engineers often learn to write Request for Proposals (RFPs), select vendors, and negotiate contracts by trial-and-error and/or by adapting previous project documents to match their own requirements. Typically, this means that at the end of a contract the engineer has a large list of do's, don'ts, and lessons learned for the next RFP he or she must generate. This paper will present one such engineer's experience writing and bidding proposal packages for large telescope components and subsystems. Included are: thoughts on structuring SOWs, Specs, ICDs, and other RFP documents; modern methods for bidding the work; and systematic means for selecting and negotiating with a contractor to arrive at the best value for the project.

Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies.

PubMed

Motoya, Satoshi; Watanabe, Mamoru; Kim, Hyo Jong; Kim, Young Ho; Han, Dong Soo; Yuasa, Hirotoshi; Tabira, Junichi; Isogawa, Naoki; Arai, Shoko; Kawaguchi, Isao; Hibi, Toshifumi

2018-04-01

Tofacitinib is an oral, small-molecule Janus kinase inhibitor being investigated for ulcerative colitis (UC). In OCTAVE Induction 1 and 2, patients with moderately to severely active UC received placebo or tofacitinib 10 mg twice daily (BID) for 8 weeks. Clinical responders in OCTAVE Induction were re-randomized to 52 weeks' therapy with placebo, tofacitinib 5 mg BID, or tofacitinib 10 mg BID. We conducted post-hoc efficacy and safety analyses of East Asian patients in OCTAVE Induction 1 and 2 and OCTAVE Sustain. A total of 121 East Asian (Japan, Korea, and Taiwan) patients were randomized in OCTAVE Induction 1 and 2 (placebo, n=26; tofacitinib 10 mg BID, n=95), and 63 in OCTAVE Sustain (placebo, n=20; tofacitinib 5 mg BID, n=22; tofacitinib 10 mg BID, n=21). At week 8 of OCTAVE Induction 1 and 2, 18.9% of patients (18/95) achieved remission with tofacitinib 10 mg BID versus 3.8% (1/26) with placebo. In OCTAVE Sustain, the week 52 remission rates were 45.5% (10/22), 47.6% (10/21), and 15.0% (3/20) with 5 mg BID, 10 mg BID, and placebo, respectively. Adverse event rates were similar between groups in OCTAVE Induction and numerically higher with tofacitinib in OCTAVE Sustain. Serious adverse event rates were similar across groups in all studies. Infections were numerically more frequent with tofacitinib than placebo. Increases in serum lipid levels were observed with tofacitinib. In East Asian patients with UC, tofacitinib demonstrated numerically greater efficacy versus placebo as induction and maintenance therapy, with a safety profile consistent with the global study population. ClinicalTrials.gov: NCT01465763; NCT01458951; NCT01458574.

Adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells.

PubMed

Long, Qifang; Yang, Ru; Lu, Weixian; Zhu, Weipei; Zhou, Jundong; Zheng, Cui; Zhou, Dongmei; Yu, Ling; Wu, Jinchang

2017-01-01

Cancer stem cells are a small subset of cancer cells that contribute to cancer progression, metastasis, chemoresistance and recurrence. CD133-positive (CD133+) ovarian cancer cells have been identified as ovarian cancer stem cells. Adenovirus-mediated gene therapy is an innovative therapeutic method for cancer treatment. In the present study, we aimed to develop a new gene therapy to specifically eliminate CD133+ ovarian cancer stem cells by targeting CD133. We used the Cre/LoxP system to augment the selective expression of the truncated Bid (tBid) gene as suicide gene therapy in CD133+ ovarian cancer stem cells. The adenovirus (Ad)-CD133-Cre expressing Cre recombinase under the control of the CD133 promoter and Ad-CMV-LoxP-Neo-LoxP-tBid expressing tBid under the control of the CMV promoter were successfully constructed using the Cre/LoxP switching system. The co-infection of Ad-CMV-LoxP-Neo-LoxP-tBid and Ad-CD133-Cre selectively induced tBid overexpression, which inhibited cell growth and triggered the cell apoptosis of CD133+ ovarian cancer stem cells. The Cre/LoxP system-mediated tBid overexpression activated the pro-apoptotic signaling pathway and augmented the cytotoxic effect of cisplatin in CD133+ ovarian cancer stem cells. Furthermore, in xenograft experiments, co-infection with the two recombinant adenoviruses markedly suppressed tumor growth in vivo and promoted cell apoptosis in tumor tissues. Taken together, the present study provides evidence that the adenovirus-mediated tBid overexpression induced by the Cre/LoxP system can effectively eliminate CD133+ ovarian cancer stem cells, representing a novel therapeutic strategy for the treatment of ovarian cancer.

Apixaban 5 and 2.5 mg twice-daily versus warfarin for stroke prevention in nonvalvular atrial fibrillation patients: Comparative effectiveness and safety evaluated using a propensity-score-matched approach.

PubMed

Li, Xiaoyan; Keshishian, Allison; Hamilton, Melissa; Horblyuk, Ruslan; Gupta, Kiran; Luo, Xuemei; Mardekian, Jack; Friend, Keith; Nadkarni, Anagha; Pan, Xianying; Lip, Gregory Y H; Deitelzweig, Steve

2018-01-01

Prior real-world studies have shown that apixaban is associated with a reduced risk of stroke/systemic embolism (stroke/SE) and major bleeding versus warfarin. However, few studies evaluated the effectiveness and safety of apixaban according to its dosage, and most studies contained limited numbers of patients prescribed 2.5 mg twice-daily (BID) apixaban. Using pooled data from 4 American claims database sources, baseline characteristics and outcomes for patients prescribed 5 mg BID and 2.5 mg BID apixaban versus warfarin were compared. After 1:1 propensity-score matching, 31,827 5 mg BID apixaban-matched warfarin patients and 6600 2.5 mg BID apixaban-matched warfarin patients were identified. Patients prescribed 2.5 mg BID apixaban were older, had clinically more severe comorbidities, and were more likely to have a history of stroke and bleeding compared with 5 mg BID apixaban patients. Compared with warfarin, 5 mg BID apixaban was associated with a lower risk of stroke/SE (hazard ratio [HR]: 0.70, 95% confidence interval [CI]: 0.60-0.81) and major bleeding (HR: 0.59, 95% CI: 0.53-0.66). Compared with warfarin, 2.5 mg BID apixaban was also associated with a lower risk of stroke/SE (HR: 0.63, 95% CI: 0.49-0.81) and major bleeding (HR: 0.59, 95% CI: 0.49-0.71). In this real-world study, both apixaban doses were assessed in 2 patient groups differing in age and clinical characteristics. Each apixaban dose was associated with a lower risk of stroke/SE and major bleeding compared with warfarin in the distinct population for which it is being prescribed in United States clinical practice. Clinicaltrials.Gov Identifier: NCT03087487.

47 CFR 80.1251 - Maritime communications subject to competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Maritime communications subject to competitive... AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Competitive Bidding Procedures § 80.1251 Maritime communications subject to competitive bidding. Mutually exclusive initial applications for VPCSA...

48 CFR 1814.302 - Bid submission. (NASA supplements paragraph (b))

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Bid submission. (NASA supplements paragraph (b)) 1814.302 Section 1814.302 Federal Acquisition Regulations System NATIONAL... 1814.302 Bid submission. (NASA supplements paragraph (b)) (b) NASA contracting officers shall not...

48 CFR 1814.302 - Bid submission. (NASA supplements paragraph (b))

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Bid submission. (NASA supplements paragraph (b)) 1814.302 Section 1814.302 Federal Acquisition Regulations System NATIONAL... 1814.302 Bid submission. (NASA supplements paragraph (b)) (b) NASA contracting officers shall not...

48 CFR 1814.302 - Bid submission. (NASA supplements paragraph (b))

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Bid submission. (NASA supplements paragraph (b)) 1814.302 Section 1814.302 Federal Acquisition Regulations System NATIONAL... 1814.302 Bid submission. (NASA supplements paragraph (b)) (b) NASA contracting officers shall not...

48 CFR 1814.302 - Bid submission. (NASA supplements paragraph (b))

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Bid submission. (NASA supplements paragraph (b)) 1814.302 Section 1814.302 Federal Acquisition Regulations System NATIONAL... 1814.302 Bid submission. (NASA supplements paragraph (b)) (b) NASA contracting officers shall not...

48 CFR 1814.302 - Bid submission. (NASA supplements paragraph (b))

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Bid submission. (NASA supplements paragraph (b)) 1814.302 Section 1814.302 Federal Acquisition Regulations System NATIONAL... 1814.302 Bid submission. (NASA supplements paragraph (b)) (b) NASA contracting officers shall not...

Cheating the Children.

ERIC Educational Resources Information Center

Rist, Marilee C.

1993-01-01

Schools are the victims, as bid-rigging scandals in the dairy-products industry surface in 13 states. School boards, in close cooperation with superintendents and district business managers, have the responsibility to detect bid-rigging or collusion. Offers guides for good business management and warning signs of bid-rigging. (MLF)

48 CFR 314.103 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 314.103 Policy. EIT products and services, including EIT deliverables such as electronic documents and reports, acquired using sealed-bid procedures shall... determinations for EIT products and services that do not meet some or all of the applicable Section 508...

13 CFR 305.10 - Bid underrun.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Bid underrun. 305.10 Section 305.10 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PUBLIC WORKS AND ECONOMIC DEVELOPMENT INVESTMENTS Requirements for Approved Projects § 305.10 Bid underrun. If...

47 CFR 101.1101 - LMDS service subject to competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false LMDS service subject to competitive bidding. 101.1101 Section 101.1101 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1101 LMDS...

47 CFR 101.1101 - LMDS service subject to competitive bidding.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false LMDS service subject to competitive bidding. 101.1101 Section 101.1101 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1101 LMDS...

47 CFR 101.1101 - LMDS service subject to competitive bidding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false LMDS service subject to competitive bidding. 101.1101 Section 101.1101 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1101 LMDS...

47 CFR 101.1101 - LMDS service subject to competitive bidding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false LMDS service subject to competitive bidding. 101.1101 Section 101.1101 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1101 LMDS...

47 CFR 101.1101 - LMDS service subject to competitive bidding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false LMDS service subject to competitive bidding. 101.1101 Section 101.1101 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1101 LMDS...

Rationality, irrationality and escalating behavior in lowest unique bid auctions.

PubMed

Radicchi, Filippo; Baronchelli, Andrea; Amaral, Luís A N

2012-01-01

Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions--lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of "bid space". The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets.

Issues in bidding for contracts for occupational therapy services.

PubMed

Harms, S; Law, M

2001-06-01

There is an increasing number of occupational therapists in Canada who are involved in bidding for contracts to deliver occupational therapy services. Occupational therapists working in an institutional or community-based setting may not have had the responsibility of developing a proposal or a marketing plan for bidding purposes. However, the responsibility of developing a bid to compete for a service delivery contract often rests on occupational therapists who are sole practitioners in a private practice setting. The purpose of this paper is to highlight issues in the literature such as service delivery plans, marketing strategies and costing of services that can assist the occupational therapist in the development of a contractual bid. A specific clinical example, school therapy services, has been used to illustrate how these strategies can be applied to practice. Success in contractual bids appears to be primarily influenced by cost of the service, the expertise of the service provider, ability to provide coordinated care, ease of access for clients, and inclusion of methods to measure client outcome.

Rationality, Irrationality and Escalating Behavior in Lowest Unique Bid Auctions

PubMed Central

Radicchi, Filippo; Baronchelli, Andrea; Amaral, Luís A. N.

2012-01-01

Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions – lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of “bid space”. The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets. PMID:22279553

Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy.

PubMed

Rebello, Candida J; Nikonova, Elena V; Zhou, Sharon; Aronne, Louis J; Fujioka, Ken; Garvey, W Timothy; Smith, Steven R; Coulter, Ann A; Greenway, Frank L

2018-02-01

This study evaluated the effect of lorcaserin 10 mg twice daily (LOR BID), or with phentermine 15 mg once daily (LOR BID + PHEN QD) and 15 mg twice daily (LOR BID + PHEN BID), in conjunction with energy restriction on food cravings. Two hundred and thirty-five patients without diabetes but with obesity or overweight and ≥ 1 comorbidity received LOR BID, LOR BID + PHEN QD, or LOR BID + PHEN BID for 12 weeks in a randomized double-blind study. The Food Craving Inventory (FCI) and the Control of Eating Questionnaire (COEQ) were administered over 12 weeks. The FCI total score and the subscale scores reduced from baseline in all groups. The least squares means (95% confidence intervals) for the total scores were -0.65 (-0.75 to -0.55), -0.75 (-0.84 to -0.65), and -0.84 (-0.95 to -0.74) in the LOR BID, LOR BID + PHEN QD, and LOR BID + PHEN BID groups, respectively. Cravings assessed by COEQ reduced from baseline in all groups. In general, the combination treatments were more effective than lorcaserin alone. At week 12, except for fruit juice and dairy products, general and specific cravings reduced in LOR BID + PHEN BID compared with LOR BID (P < 0.05). Lorcaserin in combination with phentermine improves control of food cravings during short-term energy restriction. © 2018 The Obesity Society.

24 CFR 891.535 - Requirements for awarding construction contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... bidding (formal advertising) in selecting a construction contractor or the negotiated noncompetitive... be an opportunity for minority owned and women owned businesses to be awarded a contract. (1) Bids... forth for opening of bids. In addition, the invitation shall be publicly advertised. (2) The invitation...

24 CFR 891.535 - Requirements for awarding construction contracts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... bidding (formal advertising) in selecting a construction contractor or the negotiated noncompetitive... be an opportunity for minority owned and women owned businesses to be awarded a contract. (1) Bids... forth for opening of bids. In addition, the invitation shall be publicly advertised. (2) The invitation...

47 CFR 1.2113 - Construction prior to grant of application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Competitive Bidding Proceedings General Procedures § 1.2113 Construction prior to grant of application. Subject to the provisions of this section, applicants for licenses awarded by competitive bidding may..., applicants must not begin to construct facilities for licenses subject to competitive bidding. (a) When...

47 CFR 1.2113 - Construction prior to grant of application.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Competitive Bidding Proceedings General Procedures § 1.2113 Construction prior to grant of application. Subject to the provisions of this section, applicants for licenses awarded by competitive bidding may..., applicants must not begin to construct facilities for licenses subject to competitive bidding. (a) When...

48 CFR 52.214-16 - Minimum Bid Acceptance Period.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Minimum Bid Acceptance Period. 52.214-16 Section 52.214-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... date specified in this solicitation for receipt of bids. (b) This provision supersedes any language...

47 CFR 27.209 - Designated entities; bidding credits; unjust enrichment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Designated entities; bidding credits; unjust enrichment. 27.209 Section 27.209 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON... 2305-2320 MHz and 2345-2360 MHz Bands § 27.209 Designated entities; bidding credits; unjust enrichment...

48 CFR 52.214-16 - Minimum Bid Acceptance Period.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Minimum Bid Acceptance Period. 52.214-16 Section 52.214-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... date specified in this solicitation for receipt of bids. (b) This provision supersedes any language...

48 CFR 52.214-16 - Minimum Bid Acceptance Period.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Minimum Bid Acceptance Period. 52.214-16 Section 52.214-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... date specified in this solicitation for receipt of bids. (b) This provision supersedes any language...

48 CFR 52.214-16 - Minimum Bid Acceptance Period.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Minimum Bid Acceptance Period. 52.214-16 Section 52.214-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... date specified in this solicitation for receipt of bids. (b) This provision supersedes any language...

48 CFR 52.214-16 - Minimum Bid Acceptance Period.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Minimum Bid Acceptance Period. 52.214-16 Section 52.214-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... date specified in this solicitation for receipt of bids. (b) This provision supersedes any language...

48 CFR 14.202-3 - Bid envelopes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Bid envelopes. 14.202-3 Section 14.202-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS... envelopes bearing Postage and Fees Paid indicia shall not be distributed with the invitation for bids or...

47 CFR 101.1107 - Bidding credits for very small businesses, small businesses and entrepreneurs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bidding credits for very small businesses, small businesses and entrepreneurs. 101.1107 Section 101.1107 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding...

47 CFR 101.1107 - Bidding credits for very small businesses, small businesses and entrepreneurs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Bidding credits for very small businesses, small businesses and entrepreneurs. 101.1107 Section 101.1107 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding...

47 CFR 101.1107 - Bidding credits for very small businesses, small businesses and entrepreneurs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Bidding credits for very small businesses, small businesses and entrepreneurs. 101.1107 Section 101.1107 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding...

47 CFR 101.1107 - Bidding credits for very small businesses, small businesses and entrepreneurs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Bidding credits for very small businesses, small businesses and entrepreneurs. 101.1107 Section 101.1107 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding...

47 CFR 24.717 - Bidding credits for licenses for frequency Block F.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Block F. 24.717 Section 24.717 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Competitive Bidding Procedures for Broadband PCS § 24... closed bidding in auctions that begin after March 23, 1999, a winning bidder that qualifies as a small...

47 CFR 24.712 - Bidding credits for licenses won for frequency Block C.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Block C. 24.712 Section 24.712 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Competitive Bidding Procedures for Broadband PCS § 24... closed bidding in auctions that begin after March 23, 1999, a winning bidder that qualifies as a small...

7 CFR 1753.27 - Bidding procedure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE TELECOMMUNICATIONS SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Construction of Buildings § 1753.27.... (b) The borrower shall determine that title to the real estate has been approved by RUS before the invitations to bid are released. (c) The borrower shall set the time for opening of bids, allowing ample time...

31 CFR 356.11 - How are bids submitted in an auction?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., our computer time stamp will establish the receipt time. You are bound by your bids after the closing... failures or disruptions of equipment or communications facilities used for participating in Treasury auctions. (4) Submitters are responsible for bids submitted using computer equipment on their premises...

31 CFR 356.11 - How are bids submitted in an auction?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., our computer time stamp will establish the receipt time. You are bound by your bids after the closing... failures or disruptions of equipment or communications facilities used for participating in Treasury auctions. (4) Submitters are responsible for bids submitted using computer equipment on their premises...

36 CFR 223.88 - Bidding methods.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bidding methods. 223.88... methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each sale will: (1) Insure open and fair competition, (2) Insure...

48 CFR 14.203-2 - Dissemination of information concerning invitations for bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 14.203-2 Dissemination of information concerning invitations for bids. Procedures concerning display... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Dissemination of information concerning invitations for bids. 14.203-2 Section 14.203-2 Federal Acquisition Regulations System...

30 CFR 581.18 - Bidding system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Bidding system. 581.18 Section 581.18 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF Leasing Procedures § 581.18 Bidding system...

30 CFR 581.18 - Bidding system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Bidding system. 581.18 Section 581.18 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF Leasing Procedures § 581.18 Bidding system...

30 CFR 581.18 - Bidding system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Bidding system. 581.18 Section 581.18 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF Leasing Procedures § 581.18 Bidding system...

7 CFR 1753.48 - Procurement procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

...' qualifications for all types of construction and for the required information on the bidder and subcontractors... qualified to submit bids, RUS written approval must be obtained to proceed with requesting bids. (4) Bid...) Materials on hand to be furnished by the borrower shall be released to the contractor at the start of...

30 CFR 281.18 - Bidding system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Bidding system. 281.18 Section 281.18 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF Leasing Procedures § 281.18 Bidding system. (a...

47 CFR 1.2109 - License grant, denial, default, and disqualification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROCEDURE Competitive Bidding Proceedings General Procedures § 1.2109 License grant, denial, default, and... has declared competitive bidding closed or fails to remit the required down payment within ten (10) business days after the Commission has declared competitive bidding closed, the bidder will be deemed to...

47 CFR 1.2109 - License grant, denial, default, and disqualification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... PROCEDURE Competitive Bidding Proceedings General Procedures § 1.2109 License grant, denial, default, and... has declared competitive bidding closed or fails to remit the required down payment within ten (10) business days after the Commission has declared competitive bidding closed, the bidder will be deemed to...

48 CFR 14.404-1 - Cancellation of invitations after opening.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., the agency head determines in writing that— (1) Inadequate or ambiguous specifications were cited in...) Should administrative difficulties be encountered after bid opening that may delay award beyond bidders... period specified in the bid) should be requested, before expiration of their bids, to extend in writing...

48 CFR 14.404-1 - Cancellation of invitations after opening.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., the agency head determines in writing that— (1) Inadequate or ambiguous specifications were cited in...) Should administrative difficulties be encountered after bid opening that may delay award beyond bidders... period specified in the bid) should be requested, before expiration of their bids, to extend in writing...

48 CFR 14.404-1 - Cancellation of invitations after opening.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., the agency head determines in writing that— (1) Inadequate or ambiguous specifications were cited in...) Should administrative difficulties be encountered after bid opening that may delay award beyond bidders... period specified in the bid) should be requested, before expiration of their bids, to extend in writing...

48 CFR 14.404-1 - Cancellation of invitations after opening.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., the agency head determines in writing that— (1) Inadequate or ambiguous specifications were cited in...) Should administrative difficulties be encountered after bid opening that may delay award beyond bidders... period specified in the bid) should be requested, before expiration of their bids, to extend in writing...

48 CFR 14.404-1 - Cancellation of invitations after opening.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., the agency head determines in writing that— (1) Inadequate or ambiguous specifications were cited in...) Should administrative difficulties be encountered after bid opening that may delay award beyond bidders... period specified in the bid) should be requested, before expiration of their bids, to extend in writing...

7 CFR 1726.202 - Informal competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-01-01

... persons or organizations on its qualified bidder list for the specific project (see § 1726.23). (b... a responsive bid. (d) Evaluation basis. Any factors, other than lowest dollar amount of the bid, which are to be considered in evaluating the proposals of qualified bidders (e.g., power consumption...

47 CFR 90.801 - 900 MHz SMR spectrum subject to competitive bidding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false 900 MHz SMR spectrum subject to competitive bidding. 90.801 Section 90.801 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.801 900 MHz SMR spectrum subject to competitive bidding. Mutually...

47 CFR 90.801 - 900 MHz SMR spectrum subject to competitive bidding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false 900 MHz SMR spectrum subject to competitive bidding. 90.801 Section 90.801 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.801 900 MHz SMR spectrum subject to competitive bidding. Mutually...

47 CFR 90.801 - 900 MHz SMR spectrum subject to competitive bidding.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false 900 MHz SMR spectrum subject to competitive bidding. 90.801 Section 90.801 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.801 900 MHz SMR spectrum subject to competitive bidding. Mutually...

47 CFR 90.801 - 900 MHz SMR spectrum subject to competitive bidding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false 900 MHz SMR spectrum subject to competitive bidding. 90.801 Section 90.801 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.801 900 MHz SMR spectrum subject to competitive bidding. Mutually...

48 CFR 852.247-70 - Determining transportation costs for bid evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... costs for bid evaluation. 852.247-70 Section 852.247-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 852.247-70 Determining transportation costs for bid evaluation. As prescribed in 847...

Schoolhouse Systems Project: SSP. 3rd Report.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee.

This brochure provides statistical bid breakdown for Programs 1A and 2 of the Florida Schoolhouse Systems Project. Tabular information is provided on bidders, compatible building subsystems, bid tabulation by compatibility, "per school" building subsystems, nominated bidders and lump sums, and a comparison of programs 1A and 2 bids. Data…

47 CFR 90.901 - 800 MHz SMR spectrum subject to competitive bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Competitive Bidding Procedures for 800 MHz Specialized Mobile Radio Service § 90.901 800 MHz SMR spectrum subject to competitive bidding. Mutually exclusive initial applications for 800 MHz band licenses in Spectrum Blocks A through V are subject to...

48 CFR 14.407-2 - Apparent clerical mistakes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-2 Apparent... contracting officer before award. The contracting officer first shall obtain from the bidder a verification of the bid intended. Examples of apparent mistakes are— (1) Obvious misplacement of a decimal point; (2...

48 CFR 14.407-2 - Apparent clerical mistakes.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-2 Apparent... contracting officer before award. The contracting officer first shall obtain from the bidder a verification of the bid intended. Examples of apparent mistakes are— (1) Obvious misplacement of a decimal point; (2...

47 CFR 90.1017 - Bidding credits for small businesses and very small businesses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bidding credits for small businesses and very small businesses. 90.1017 Section 90.1017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... the 220 MHz Service § 90.1017 Bidding credits for small businesses and very small businesses. A...

48 CFR 14.405 - Minor informalities or irregularities in bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Minor informalities or... Minor informalities or irregularities in bids. A minor informality or irregularity is one that is merely... cure any deficiency resulting from a minor informality or irregularity in a bid or waive the deficiency...

48 CFR 14.405 - Minor informalities or irregularities in bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Minor informalities or... Minor informalities or irregularities in bids. A minor informality or irregularity is one that is merely... cure any deficiency resulting from a minor informality or irregularity in a bid or waive the deficiency...

7 CFR 1753.8 - Contract construction procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of all bids including “Buy American” evaluations, if any, and all other evaluations required by law... Contract construction procedures. (a) Sealed, competitive bidding—(1) Bid opening date. The borrower is responsible for scheduling the bid opening date. If RUS review of P&S is required by § 1753.7, the borrower...

47 CFR 73.5007 - Designated entity provisions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... lower the cost of its winning bid on any broadcast construction permit. Any winning bidder claiming new... underlying its new entrant bidding credit eligibility claim, or that of any attributable interest-holder in... of the new entrant bidding credit claimed in the applicant's FCC Form 175 application, if the change...

47 CFR 73.5007 - Designated entity provisions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... lower the cost of its winning bid on any broadcast construction permit. Any winning bidder claiming new... underlying its new entrant bidding credit eligibility claim, or that of any attributable interest-holder in... of the new entrant bidding credit claimed in the applicant's FCC Form 175 application, if the change...

47 CFR 73.5007 - Designated entity provisions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... lower the cost of its winning bid on any broadcast construction permit. Any winning bidder claiming new... underlying its new entrant bidding credit eligibility claim, or that of any attributable interest-holder in... of the new entrant bidding credit claimed in the applicant's FCC Form 175 application, if the change...

47 CFR 73.5007 - Designated entity provisions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... lower the cost of its winning bid on any broadcast construction permit. Any winning bidder claiming new... underlying its new entrant bidding credit eligibility claim, or that of any attributable interest-holder in... of the new entrant bidding credit claimed in the applicant's FCC Form 175 application, if the change...

47 CFR 73.5007 - Designated entity provisions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... lower the cost of its winning bid on any broadcast construction permit. Any winning bidder claiming new... underlying its new entrant bidding credit eligibility claim, or that of any attributable interest-holder in... of the new entrant bidding credit claimed in the applicant's FCC Form 175 application, if the change...

47 CFR 90.910 - Bidding credits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND....910 Bidding credits. A winning bidder that qualifies as a very small business, as defined in § 90.912(b)(2), or a consortium of very small businesses may use a bidding credit of 35 percent to lower the...

47 CFR 1.2105 - Bidding application and certification procedures; prohibition of certain communications.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... (6) Any applicant that makes or receives a communication of bids or bidding strategies prohibited under paragraph (c)(1) of this section shall report such communication in writing to the Commission... procedures; prohibition of certain communications. 1.2105 Section 1.2105 Telecommunication FEDERAL...

47 CFR 90.1017 - Bidding credits for small businesses and very small businesses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Bidding credits for small businesses and very small businesses. 90.1017 Section 90.1017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... the 220 MHz Service § 90.1017 Bidding credits for small businesses and very small businesses. A...

47 CFR 90.1017 - Bidding credits for small businesses and very small businesses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Bidding credits for small businesses and very small businesses. 90.1017 Section 90.1017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... the 220 MHz Service § 90.1017 Bidding credits for small businesses and very small businesses. A...

47 CFR 90.1017 - Bidding credits for small businesses and very small businesses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Bidding credits for small businesses and very small businesses. 90.1017 Section 90.1017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... the 220 MHz Service § 90.1017 Bidding credits for small businesses and very small businesses. A...

47 CFR 90.1017 - Bidding credits for small businesses and very small businesses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bidding credits for small businesses and very small businesses. 90.1017 Section 90.1017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... the 220 MHz Service § 90.1017 Bidding credits for small businesses and very small businesses. A...

48 CFR 225.870-3 - Submission of offers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... sealed bids in terms of U.S. currency. Do not adjust contracts awarded under sealed bidding for losses or gains from fluctuation in exchange rates. (d) Except for sealed bids, the Canadian Commercial Corporation normally will submit offers and quotations in terms of Canadian currency. The Corporation may, at...

Competition in the economic crisis: Analysis of procurement auctions.

PubMed

Gugler, Klaus; Weichselbaumer, Michael; Zulehner, Christine

2015-01-01

We study the effects of the recent economic crisis on firms׳ bidding behavior and markups in sealed bid auctions. Using data from Austrian construction procurements, we estimate bidders׳ construction costs within a private value auction model. We find that markups of all bids submitted decrease by 1.5 percentage points in the recent economic crisis, markups of winning bids decrease by 3.3 percentage points. We also find that without the government stimulus package this decrease would have been larger. These two pieces of evidence point to pro-cyclical markups.

Competitive bidding for home care under the channeling demonstration

PubMed Central

Christianson, Jon B.

1987-01-01

Competitive bidding is a relatively new strategy for setting rates and choosing providers for public medical care programs. In this article, the experience in competitive bidding by home health care providers and homemaker agencies in the National Long-Term Care Channeling Demonstration is described. Particular attention is paid to contrasting approaches that select a single winning bidder with those that select multiple winning bidders for the same service. Results are discussed with respect to bid prices, characteristics of winning bidders, administrative demands, and service delivery. PMID:10312190

Standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori eradication

PubMed Central

Gao, Xiao-Zhong; Qiao, Xiu-Li; Song, Wen-Chong; Wang, Xiao-Feng; Liu, Feng

2010-01-01

AIM: To compare the effectiveness of standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori (H. pylori) eradication in a randomized, double-blinded, comparative clinical trial in China. METHODS: A total of 215 H. pylori-positive patients were enrolled in the study and randomly allocated into three groups: group A (n = 72) received a 10-d bismuth pectin quadruple therapy (20 mg rabeprazole bid, 1000 mg amoxicillin bid, 100 mg bismuth pectin qid, and 500 mg levofloxacin qd); group B (n = 72) received the sequential therapy (20 mg omeprazole bid, 1000 mg amoxicillin bid, in 5 d, followed by 20 mg omeprazole bid, 500 mg tinidazole bid, 500 mg clarithromycin bid, for another 5 d); group C (n = 71) received a standard 1-wk triple therapy (20 mg omeprazole bid, 1000 mg amoxicillin bid, 500 mg clarithromycin bid). After all these treatments, 20 mg omeprazole bid was administrated for 3 wk. H. pylori status was assessed by histology, 13C-urea breath test and rapid urease test at baseline and 4-6 wk after completion of treatment. Ulcer cicatrization was assessed by gastroscopy. χ2 test (P < 0.05) was used to compare the eradication rates and ulcer cicatrisation rates among the three groups. RESULTS: The eradication rate was 83.33% (60/72) in group A, 88.89% (64/72) in group B, and 80.56% (58/71) in group C. The ulcer cicatrisation rate was 86.44% (51/59) in group A, 90.16% (55/61) in group B, and 84.91% (45/53) in group C. The sequential therapy yielded a higher eradication rate and ulcer cicatrisation rate than the standard triple and bismuth pectin quadruple therapies. Statistically, the eradication rate of group B was significantly different from groups A and C (P < 0.05), but the difference of ulcer cicatrisation rate and side effects was not statistically significant among the three groups (P > 0.05). The three protocols were generally well tolerated. CONCLUSION: The sequential therapy has achieved a significantly higher eradication rate, and is a more suitable first-line alternative protocol for anti-H. pylori infection compared with the standard triple and bismuth pectin quadruple therapies. PMID:20818821

Bid opening report : Federal-aid highway construction contracts : first six months 1998

DOT National Transportation Integrated Search

1999-07-01

This document presents human factors guidelines for designers, owners operators, and planners involved in the development and operation of traffic management centers. Dimensions of the work environment affecting operator and system performance are ad...

Real-Time Robust Adaptive Modeling and Scheduling for an Electronic Commerce Server

NASA Astrophysics Data System (ADS)

Du, Bing; Ruan, Chun

With the increasing importance and pervasiveness of Internet services, it is becoming a challenge for the proliferation of electronic commerce services to provide performance guarantees under extreme overload. This paper describes a real-time optimization modeling and scheduling approach for performance guarantee of electronic commerce servers. We show that an electronic commerce server may be simulated as a multi-tank system. A robust adaptive server model is subject to unknown additive load disturbances and uncertain model matching. Overload control techniques are based on adaptive admission control to achieve timing guarantees. We evaluate the performance of the model using a complex simulation that is subjected to varying model parameters and massive overload.

13 CFR 500.211 - Lender responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Monitoring. In accordance with the Guarantee the Lender shall monitor Borrower's performance under the Loan... borrower, as provided in the Guarantee; (2) Projected balance sheet, income statement, and cash flows for...

Twice-daily and three-times-daily dosing of a repaglinide/metformin fixed-dose combination tablet provide similar glycaemic control.

PubMed

Raskin, P; Lewin, A; Reinhardt, R; Lyness, W

2009-10-01

To assess the efficacy and safety of a new repaglinide/metformin fixed-dose combination (FDC) tablet administered either twice a day (BID) or three times a day (TID) for the management of type 2 diabetes. This was a 26-week, multicentre, open-label parallel trial in which subjects poorly controlled with mono- or dual-oral antidiabetic therapy were randomized 1 : 1 : 1 to instead receive repaglinide/metformin FDC either BID or TID or a rosiglitazone/metformin FDC BID. Two primary hypotheses were tested in a hierarchical manner: (i) treatment with the repaglinide/metformin FDC BID is non-inferior to that of the rosiglitazone/metformin FDC BID as measured by changes in haemoglobin A1c (HbA1c) (results presented in companion paper) and (ii) repaglinide/metformin BID is non-inferior to repaglinide/metformin TID (as measured by changes in HbA1c). Additional efficacy and safety end-points were also assessed. A total of 561 subjects were randomized; 383 completed the study. Repaglinide/metformin FDC BID was non-inferior to repaglinide/metformin FDC TID with respect to HbA1c. Additionally, changes in mean fasting plasma glucose values from baseline to end of study were not significantly different between the BID and the TID dose groups. There were no major hypoglycaemic episodes reported in either group during the trial, and overall adverse event profiles were similar. The efficacy of twice-daily dosing of a repaglinide/metformin FDC tablet was non-inferior to that of three-times-daily dosing.

Susceptibility of Hep3B cells in different phases of cell cycle to tBid.

PubMed

Ma, Shi-Hong; Chen, George G; Ye, Caiguo; Leung, Billy C S; Ho, Rocky L K; Lai, Paul B S

2011-01-01

tBid is a pro-apoptotic molecule. Apoptosis inducers usually act in a cell cycle-specific fashion. The aim of this study was to elucidate whether effect of tBid on hepatocellular carcinoma (HCC) Hep3B cells was cell cycle phase specific. We synchronized Hep3B cells at G0/G1, S or G2/M phases by chemicals or flow sorting and tested the susceptibility of the cells to recombinant tBid. Cell viability was measured by MTT assay and apoptosis by TUNEL. The results revealed that tBid primarily targeted the cells at G0/G1 phase of cell cycle, and it also increased the cells at the G2/M phase. 5-Fluorouracil (5-FU), on the other hand, arrested Hep3B cells at the G0/G1 phase, but significantly reduced cells at G2/M phase. The levels of cell cycle-related proteins and caspases were altered in line with the change in the cell cycle. The combination of tBid with 5-FU caused more cells to be apoptotic than either agent alone. Therefore, the complementary effect of tBid and 5-FU on different phases of the cell cycle may explain their synergistric effect on Hep3B cells. The elucidation of the phase-specific effect of tBid points to a possible therapeutic option that combines different phase specific agents to overcome resistance of HCC. Copyright © 2010 Elsevier B.V. All rights reserved.

Medical Surveillance Monthly Report. Volume 20, Number 11

DTIC Science & Technology

2013-11-01

5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Medical Surveillance Monthly Report (MSMR),Armed Forces...Health Surveillance Center,11800 Tech Road, Suite 220 (MCAF-CS),Silver Spring,MD,20904 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING... performed to determine the circumstances surrounding the event, the week of train- ing (WOT) in which it occurred, comor- bid conditions diagnosed

We Are Spanish, Born under Franco's Dictatorship, and We Are Developing the Posbolonian Uniform Performance as a Form of Global Activism

ERIC Educational Resources Information Center

Camarero, Pilar Pérez; Cruzado, Raúl Díaz-Obregón

2013-01-01

The Posbolonian Uniform is a creative, artistic and performative response, undertaken as a criticism and opposition to the losses of democratic freedoms that have occurred in Spain recently. It is a bid by two university instructors for the use of artistic tools, specifically performance art, as a means of social transformation in their academic…

48 CFR 536.213-371 - Bids that include options.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Bids that include options... Contracting for Construction 536.213-371 Bids that include options. (a) Subject to the limitations in paragraph (c) of this section, you may include options in contracts if it is in the Government's interest...

31 CFR 340.6 - Submission of bids.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Submission of bids. 340.6 Section 340.6 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... Secretary of the Treasury may limit the premium above or the discount below par. (c) Group bids. A syndicate...

48 CFR 3.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and marking of contractor bid or proposal information and source selection information. 3.104-4... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Safeguards 3.104-4 Disclosure, protection, and marking of contractor bid or proposal information and source selection information. (a) Except as...

48 CFR 203.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and marking of contractor bid or proposal information and source selection information. 203.104-4..., DEPARTMENT OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Safeguards 203.104-4 Disclosure, protection, and marking of contractor bid or proposal information and source...

48 CFR 2903.104-5 - Disclosure, protection, and marking of contractor bid or proposal information and source...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and marking of contractor bid or proposal information and source selection information. 2903.104-5... PRACTICES AND PERSONAL CONFLICTS OF INTEREST Safeguards 2903.104-5 Disclosure, protection, and marking of contractor bid or proposal information and source selection information. (a) Government employees serving in...

45 CFR 1634.3 - Competition for grants and contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CORPORATION COMPETITIVE BIDDING FOR GRANTS AND CONTRACTS § 1634.3 Competition for grants and contracts. (a... Corporation under Section 1006(a)(1)(A) of the LSC Act shall be subject to the competitive bidding process... selected on the basis of the competitive bidding process described in this part. (b) The Corporation shall...

45 CFR 1634.3 - Competition for grants and contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CORPORATION COMPETITIVE BIDDING FOR GRANTS AND CONTRACTS § 1634.3 Competition for grants and contracts. (a... Corporation under Section 1006(a)(1)(A) of the LSC Act shall be subject to the competitive bidding process... selected on the basis of the competitive bidding process described in this part. (b) The Corporation shall...

48 CFR 19.202-3 - Equal low bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-3 Equal low bids. In the event of equal low bids (see 14.408-6), awards shall be made first to small business concerns which are also labor surplus area concerns, and second to small business concerns which are not also labor surplus area concerns. [60 FR...

48 CFR 52.214-28 - Subcontractor Certified Cost or Pricing Data-Modifications-Sealed Bidding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Cost or Pricing Data-Modifications-Sealed Bidding. 52.214-28 Section 52.214-28 Federal Acquisition... CONTRACT CLAUSES Text of Provisions and Clauses 52.214-28 Subcontractor Certified Cost or Pricing Data... Cost or Pricing Data—Modifications—Sealed Bidding (OCT 2010) (a) The requirements of paragraphs (b) and...

48 CFR 242.771 - Independent research and development and bid and proposal costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SERVICES Indirect Cost Rates 242.771 Independent research and development and bid and proposal costs. ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Independent research and development and bid and proposal costs. 242.771 Section 242.771 Federal Acquisition Regulations System DEFENSE...

48 CFR 970.3102-05-18 - Independent research and development and bid and proposal costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... proposal costs. (c) Independent Research and Development and Bid and Proposal costs are unallowable... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Independent research and development and bid and proposal costs. 970.3102-05-18 Section 970.3102-05-18 Federal Acquisition Regulations...

An Antitrust Primer: How To Avoid Bid Rigging and Other Collusions.

ERIC Educational Resources Information Center

Connolly, Robert E.

1997-01-01

Shows school business officials how to detect and avoid bid rigging, price fixing, and other types of unlawful collusion prohibited by the Sherman Antitrust Act. School administrators should expand the list of bidders, consolidate purchases as a defensive tactic, consider reletting the contract in tie-bid situations, recognize the elements of…

47 CFR 1.2200 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... licensee means the licensee of (1) A full-power television station, or (2) A low-power television station...-low-VHF bid. The term high-VHF-to-low-VHF bid means a bid to relinquish all spectrum usage rights with... receiving spectrum usage rights with respect to a low VHF television channel (channels 2 through 6). (g...

"Changes in Purchasing Practices of School Insurances -- or, To Bid or not To Bid."

ERIC Educational Resources Information Center

Crockett, James E.

This speech concentrates on a discussion of the increasing difficulty that school districts are experiencing in obtaining insurance coverage. The speaker offers school administrators some suggestions to assist them in securing the necessary coverage and suggests that when an insurance market is open and competitive, purchasing through bidding is…

48 CFR 14.503-2 - Step two.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Step two. 14.503-2 Section... AND CONTRACT TYPES SEALED BIDDING Two-Step Sealed Bidding 14.503-2 Step two. (a) Sealed bidding... submitting acceptable technical proposals in step one; (2) Include the provision prescribed in 14.201-6(t...

7 CFR 1955.147 - Sealed bid sales.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Sealed bid sales. 1955.147 Section 1955.147... Sealed bid sales. This section provides guidance on the sale of all FmHA or its successor agency under Public Law 103-354 inventory property, except suitable FP real property which will not be sold by sealed...

42 CFR 423.279 - National average monthly bid amount.

Code of Federal Regulations, 2010 CFR

2010-10-01

... bid amounts for each prescription drug plan (not including fallbacks) and for each MA-PD plan...(h) of the Act. (b) Calculation of weighted average. (1) The national average monthly bid amount is a....258(c)(1) of this chapter) and the denominator equal to the total number of Part D eligible...

42 CFR 423.279 - National average monthly bid amount.

Code of Federal Regulations, 2011 CFR

2011-10-01

... bid amounts for each prescription drug plan (not including fallbacks) and for each MA-PD plan...(h) of the Act. (b) Calculation of weighted average. (1) The national average monthly bid amount is a....258(c)(1) of this chapter) and the denominator equal to the total number of Part D eligible...

48 CFR 52.203-2 - Certificate of Independent Price Determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... offeror or competitor before bid opening (in the case of a sealed bid solicitation) or contract award (in the case of a negotiated solicitation) unless otherwise required by law; and (3) No attempt has been... for determining the prices being offered in this bid or proposal, and that the signatory has not...

30 CFR 256.32 - Notice of sale.

Code of Federal Regulations, 2010 CFR

2010-07-01

... bids shall be filed, and the place, date and hour at which bids shall be opened. The notice shall... conditions of the sale. (b) Tracts shall be offered for lease by competitive sealed bidding under conditions specified in the notice of lease sale and in accordance with all applicable laws and regulations. A...

Mithramycin A induces apoptosis by regulating the mTOR/Mcl-1/tBid pathway in androgen-independent prostate cancer cells

PubMed Central

Choi, Eun-Sun; Chung, Taeho; Kim, Jun-Sung; Lee, Hakmo; Kwon, Ki Han; Cho, Nam-Pyo; Cho, Sung-Dae

2013-01-01

Mithramycin A (Mith) is an aureolic acid-type polyketide produced by various soil bacteria of the genus Streptomyces. Mith inhibits myeloid cell leukemia-1 (Mcl-1) to induce apoptosis in prostate cancer, but the molecular mechanism underlying this process has not been fully elucidated. The aim of this study was therefore to investigate the detailed molecular mechanism related to Mith-induced apoptosis in prostate cancer cells. Mith decreased the phosphorylation of mammalian target of rapamycin (mTOR) in both cell lines overexpressing phospho-mTOR compared to RWPE-1 human normal prostate epithelial cells. Mith significantly induced truncated Bid (tBid) and siRNA-mediated knock-down of Mcl-1 increased tBid protein levels. Moreover, Mith also inhibited the phosphorylation of mTOR on serine 2448 and Mcl-1, and increased tBid protein in prostate tumors in athymic nude mice bearing DU145 cells as xenografts. Thus, Mith acts as an effective tumor growth inhibitor in prostate cancer cells through the mTOR/Mcl-1/tBid signaling pathway. PMID:24062605

Guaranteed cost control with poles assignment for a flexible air-breathing hypersonic vehicle

NASA Astrophysics Data System (ADS)

Li, Hongyi; Si, Yulin; Wu, Ligang; Hu, Xiaoxiang; Gao, Huijun

2011-05-01

This article investigates the problem of guaranteed cost control for a flexible air-breathing hypersonic vehicle (FAHV). The FAHV includes intricate coupling between the engine and flight dynamics as well as complex interplay between flexible and rigid modes, which results in an intractable system for the control design. A longitudinal model is adopted for control design due to the complexity of the vehicle. First, for a highly nonlinear and coupled FAHV, a linearised model is established around the trim condition, which includes the state of altitude, velocity, angle of attack, pitch angle and pitch rate, etc. Secondly, by using the Lyapunov approach, performance analysis is carried out for the resulting closed-loop FAHV system, whose criterion with respect to guaranteed performance cost and poles assignment is expressed in the framework of linear matrix inequalities (LMIs). The established criterion exhibits a kind of decoupling between the Lyapunov positive-definite matrices to be determined and the FAHV system matrices, which is enabled by the introduction of additional slack matrix variables. Thirdly, a convex optimisation problem with LMI constraints is formulated for designing an admissible controller, which guarantees a prescribed performance cost with the simultaneous consideration of poles assignment for the resulting closed-loop system. Finally, some simulation results are provided to show that the guaranteed cost controller could assign the poles into the desired regional and achieve excellent reference altitude and velocity tracking performance.

Asphalt mixture cold temperature performance using the Bending Beam Rheometer (BBR).

DOT National Transportation Integrated Search

2013-03-01

The use of recycled materials providing substitution of virgin binder in asphalt mixtures : continues to increase. The current level of funding for highway construction is : significantly less than 3 years ago and the level of competition between bid...

Essays in financial transmission rights pricing

NASA Astrophysics Data System (ADS)

Posner, Barry

This work examines issues in the pricing of financial transmission rights in the PJM market region. The US federal government is advocating the creation of large-scale, not-for-profit regional transmission organizations to increase the efficiency of the transmission of electricity. As a non-profit entity, PJM needs to allocate excess revenues collected as congestion rents, and the participants in the transmission markets need to be able to hedge their exposure to congestion rents. For these purposes, PJM has developed an instrument known as the financial transmission right (FTR). This research, utilizing a new data set assembled by the author, looks at two aspects of the FTR market. The first chapter examines the problem of forecasting congestion in a transmission grid. In the PJM FTR system firms bid in a competitive auction for FTRs that cover a period of one month. The auctions take place in the middle of the previous month; therefore firms have to forecast congestion rents for the period two to six weeks after the auction. The common methods of forecasting congestion are either time-series models or full-information engineering studies. In this research, the author develops a forecasting system that is more economically grounded than a simple time-series model, but requires less information than an engineering model. This method is based upon the arbitrage-cost methodology, whereby congesting is calculated as the difference of two non-observable variables: the transmission price difference that would exist in the total absence of transmission capacity between two nodes, and the ability of the existing transmission to reduced that price difference. If the ability to reduce the price difference is greater than the price difference, then the cost of electricity at each node will be the same, and congestion rent will be zero. If transmission capacity limits are binding on the flow of power, then a price difference persists and congestion rents exist. Three transmission paths in the Delmarva Peninsula were examined. The maximum-likelihood two-way Tobit model developed in Chapter One consistently predicts the expected responses to the independent variables that have employed, but the model as defined here does a poor job of predicting prices. This is likely due to the inability to include system outages (i.e., short-term changes in the structure of the transmission grid) as variables in the estimation model. The second chapter addresses the behavior of firms in the monthly auctions for FTRs. FTRs are a claim to congestion rent revenues along a certain path within the PJM grid, and are awarded in a uniform-price divisible-goods auction. Firms typically submit a schedule of bids for different amounts of FTR at different prices, akin to a demand curve. A firm bidding too high a price may cause the clearing price of the FTR to be higher than the realized value of the FTR, creating a loss from ownership of the FTR. A firm bidding too low means that it wins no FTRs, depriving itself of the ability to profit from ownership or to hedge against congestion. Several questions concerning firm behavior are addressed in this study. It is found that firms adjust their bids in response to new information that is obtained from past auctions: they raise or lower bids in accordance with changes in recent FTR prices and payoffs. Firms consistently bid below the value of the FTR (i.e., shade their bids). This adds empirical evidence to the theoretically-posited notion that uniform-price auctions are not truth-telling, unlike the second-price auction for a non-divisible good. Firms employ greater bid-shading in response to increases in the volatility of both FTR clearing prices and realized FTR values. This validates the notion that firms are risk-averse. It is discovered that better-informed "insider" firms employ structurally different bidding strategies, but these differences do not lead to greater profits. However, profits do increase as firms gain more experience in these markets, lending credence to the notion that firms learn over time and that markets discipline poorly performing firms by either educating them or driving them out of the market. It is also found that firms that employ complicated bidding strategies enjoy greater profitability than firms which employ simple bidding strategies. A surprising corollary finding is that firm strategies do not converge to a common form, but that different firms continue to employ different strategies, and often move away from the seemingly dominant strategy. Firms can enter this market as either long-buyers or short-sellers, and it is discovered that long and short players display structurally divergent bidding strategies. This is perhaps unsurprising, given that long players can be either hedgers or speculators, but short players are overwhelmingly speculators.

Apixaban 5 and 2.5 mg twice-daily versus warfarin for stroke prevention in nonvalvular atrial fibrillation patients: Comparative effectiveness and safety evaluated using a propensity-score-matched approach

PubMed Central

Keshishian, Allison; Hamilton, Melissa; Horblyuk, Ruslan; Gupta, Kiran; Luo, Xuemei; Mardekian, Jack; Friend, Keith; Nadkarni, Anagha; Pan, Xianying; Lip, Gregory Y. H.; Deitelzweig, Steve

2018-01-01

Prior real-world studies have shown that apixaban is associated with a reduced risk of stroke/systemic embolism (stroke/SE) and major bleeding versus warfarin. However, few studies evaluated the effectiveness and safety of apixaban according to its dosage, and most studies contained limited numbers of patients prescribed 2.5 mg twice-daily (BID) apixaban. Using pooled data from 4 American claims database sources, baseline characteristics and outcomes for patients prescribed 5 mg BID and 2.5 mg BID apixaban versus warfarin were compared. After 1:1 propensity-score matching, 31,827 5 mg BID apixaban-matched warfarin patients and 6600 2.5 mg BID apixaban-matched warfarin patients were identified. Patients prescribed 2.5 mg BID apixaban were older, had clinically more severe comorbidities, and were more likely to have a history of stroke and bleeding compared with 5 mg BID apixaban patients. Compared with warfarin, 5 mg BID apixaban was associated with a lower risk of stroke/SE (hazard ratio [HR]: 0.70, 95% confidence interval [CI]: 0.60–0.81) and major bleeding (HR: 0.59, 95% CI: 0.53–0.66). Compared with warfarin, 2.5 mg BID apixaban was also associated with a lower risk of stroke/SE (HR: 0.63, 95% CI: 0.49–0.81) and major bleeding (HR: 0.59, 95% CI: 0.49–0.71). In this real-world study, both apixaban doses were assessed in 2 patient groups differing in age and clinical characteristics. Each apixaban dose was associated with a lower risk of stroke/SE and major bleeding compared with warfarin in the distinct population for which it is being prescribed in United States clinical practice. Trial registration: Clinicaltrials.Gov Identifier: NCT03087487. PMID:29373602

A phase II trial of huperzine A in mild to moderate Alzheimer disease

PubMed Central

Walsh, S.; Little, J.T.; Behan, K.; Reynolds, B.; Ward, C.; Jin, S.; Thomas, R.; Aisen, P.S.

2011-01-01

Objective: Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata that may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use for Alzheimer disease (AD). Methods: We assessed the safety, tolerability, and efficacy of huperzine A in mild to moderate AD in a multicenter trial in which 210 individuals were randomized to receive placebo (n = 70) or huperzine A (200 μg BID [n = 70] or 400 μg BID [n = 70]), for at least 16 weeks, with 177 subjects completing the treatment phase. The primary analysis assessed the cognitive effects of huperzine A 200 μg BID (change in Alzheimer's Disease Assessment Scale–cognitive subscale [ADAS-Cog] at week 16 at 200 μg BID compared to placebo). Secondary analyses assessed the effect of huperzine A 400 μg BID, as well as effect on other outcomes including Mini-Mental State Examination, Alzheimer's Disease Cooperative Study–Clinical Global Impression of Change scale, Alzheimer's Disease Cooperative Study Activities of Daily Living scale, and Neuropsychiatric Inventory (NPI). Results: Huperzine A 200 μg BID did not influence change in ADAS-Cog at 16 weeks. In secondary analyses, huperzine A 400 μg BID showed a 2.27-point improvement in ADAS-Cog at 11 weeks vs 0.29-point decline in the placebo group (p = 0.001), and a 1.92-point improvement vs 0.34-point improvement in the placebo arm (p = 0.07) at week 16. Changes in clinical global impression of change, NPI, and activities of daily living were not significant at either dose. Conclusion: The primary efficacy analysis did not show cognitive benefit with huperzine A 200 μg BID. Classification of evidence: This study provides Class III evidence that huperzine A 200 μg BID has no demonstrable cognitive effect in patients with mild to moderate AD. PMID:21502597

Asenapine for the treatment of adults with an acute exacerbation of schizophrenia: results from a randomized, double-blind, fixed-dose, placebo-controlled trial with olanzapine as an active control.

PubMed

Landbloom, Ronald; Mackle, Mary; Wu, Xiao; Kelly, Linda; Snow-Adami, Linda; McIntyre, Roger S; Mathews, Maju; Hundt, Carla

2017-08-01

Evaluate the efficacy and safety of asenapine 2.5 mg twice daily (bid; n=97) or 5 mg bid (n=113) versus placebo (n=101) in adults with acute exacerbation of schizophrenia. Adults with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) schizophrenia diagnosis were randomized to asenapine 2.5 mg bid, 5 mg bid, placebo, or olanzapine 15 mg once daily. The primary objective was to test superiority of asenapine versus placebo as measured by the change from baseline to day 42 in the Positive and Negative Syndrome Scale (PANSS) total score. The key safety objective was to evaluate weight change in asenapine versus olanzapine at day 42. The primary efficacy endpoint was met; the difference in least squares mean change from baseline to day 42 in PANSS total score between asenapine 5 mg bid and placebo was -5.5 points (unadjusted 95% CI: -10.1, -1.0; multiplicity adjusted P=0.0356). Neither asenapine 2.5 mg bid nor olanzapine 15mg were superior to placebo. Both asenapine groups demonstrated significantly less weight gain than olanzapine at day 42. Significantly higher incidences of oral hypoesthesia and dysgeusia (combined) for asenapine 2.5 mg bid (5.2% vs 0.0%; P=0.0217) and 5 mg bid (7.1% vs 0.0%; P=0.0033) were observed versus placebo. There were no significant differences between asenapine and placebo for insomnia, extrapyramidal symptoms, akathisia, dizziness, or combination of somnolence/sedation/hypersomnia. This study supports previous efficacy and safety findings of asenapine; asenapine 5 mg bid is the lowest effective dose in adults with schizophrenia. Asenapine was associated with significantly less weight gain than olanzapine at day 42.

Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy.

PubMed

Neßler, Jasmin; Rundfeldt, Chris; Löscher, Wolfgang; Kostic, Draginja; Keefe, Thomas; Tipold, Andrea

2017-01-25

Imepitoin was tested as a combination treatment with phenobarbital in an open-label mono-centre cohort study in dogs with drug-resistant epilepsy. Diagnosis of idiopathic epilepsy was based on clinical findings, magnetic resonance imaging and cerebrospinal fluid analysis. Three cohorts were treated. In cohort A, dogs not responding to phenobarbital with or without established add-on treatment of potassium bromide or levetiracetam were treated add-on with imepitoin, starting at 10 mg/kg BID, with titration allowed to 30 mg/kg BID. In cohort B, the only difference to cohort A was that the starting dose of imepitoin was reduced to 5 mg/kg BID. In cohort C, animals not responding to imepitoin at >20 mg/kg BID were treated with phenobarbital add-on starting at 0.5 mg/kg BID. The add-on treatment resulted in a reduction in monthly seizure frequency (MSF) in all three cohorts. A reduction of ≥50% was obtained in 36-42% of all animals, without significant difference between cohorts. The lower starting dose of 5 mg/kg BID imepitoin was better tolerated, and an up-titration to on average of 15 mg/kg BID was sufficient in cohort A and B. In cohort C, a mean add-on dose of 1.5 mg/kg BID phenobarbital was sufficient to achieve a clinically meaningful effect. Six dogs developed a clinically meaningful increase in MSF of ≥ 50%, mostly in cohort A. Neither imepitoin nor phenobarbital add-on treatment was capable of suppressing cluster seizure activity, making cluster seizure activity an important predictor for drug-resistance. A combination treatment of imepitoin and phenobarbital is a useful treatment option for a subpopulation of dogs with drug-resistant epilepsy, a low starting dose with 5 mg/kg BID is recommended.

Bidding factors-the reduction of the data dimension with the use of PCA

NASA Astrophysics Data System (ADS)

Leśniak, Agnieszka

2017-07-01

Making the decision to participate in the tender is subject to a number of factors, affects the health of the company and is an important aspect in its quest for success. Efforts to select bidding factors have been repeatedly undertaken in various countries and in numerous construction markets. Researchers usually give a long list of factors, also called criteria, which in their opinion may significantly influence the bidding decision. The paper presents an attempt to reduce a proposed set of bidding factorsdefined in Poland with the use of thePrincipal Component Analysis.

Research on power market technical analysis index system employing high-low matching mechanism

NASA Astrophysics Data System (ADS)

Li, Tao; Wang, Shengyu

2018-06-01

The power market trading technical analysis refers to a method that takes the bidding behavior of members in the power market as the research object, sums up some typical market rules and price trends by applying mathematical and logical methods, and finally can effectively assist members in the power market to make more reasonable trading decisions. In this paper, the following four indicators have been proposed: bidding price difference scale, extreme bidding price rate, dispersion of bidding price and monthly transaction satisfaction of electricity trading, which are the core of the index system.

Abstraction and Assume-Guarantee Reasoning for Automated Software Verification

NASA Technical Reports Server (NTRS)

Chaki, S.; Clarke, E.; Giannakopoulou, D.; Pasareanu, C. S.

2004-01-01

Compositional verification and abstraction are the key techniques to address the state explosion problem associated with model checking of concurrent software. A promising compositional approach is to prove properties of a system by checking properties of its components in an assume-guarantee style. This article proposes a framework for performing abstraction and assume-guarantee reasoning of concurrent C code in an incremental and fully automated fashion. The framework uses predicate abstraction to extract and refine finite state models of software and it uses an automata learning algorithm to incrementally construct assumptions for the compositional verification of the abstract models. The framework can be instantiated with different assume-guarantee rules. We have implemented our approach in the COMFORT reasoning framework and we show how COMFORT out-performs several previous software model checking approaches when checking safety properties of non-trivial concurrent programs.

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.

PubMed

Wicki, Simone; Gurzeler, Ursina; Corazza, Nadia; Genitsch, Vera; Wong, Wendy Wei-Lynn; Kaufmann, Thomas

2018-02-28

Neutrophils are key players in the early defense against invading pathogens. Due to their potent effector functions, programmed cell death of activated neutrophils has to be tightly controlled; however, its underlying mechanisms remain unclear. Fas ligand (FASL/CD95L) has been shown to induce neutrophil apoptosis, which is accelerated by the processing of the BH3-only protein BH3 interacting domain death agonist (BID) to trigger mitochondrial apoptotic events, and been attributed a regulatory role during viral and bacterial infections. Here, we show that, in accordance with previous works, mouse neutrophils underwent caspase-dependent apoptosis in response to FASL, and that this cell death was significantly delayed upon loss of BID. However, pan-caspase inhibition failed to protect mouse neutrophils from FASL-induced apoptosis and caused a switch to RIPK3-dependent necroptotic cell death. Intriguingly, such a switch was less evident in the absence of BID, particularly under inflammatory conditions. Delayed neutrophil apoptosis has been implicated in several auto-inflammatory diseases, including inflammatory bowel disease. We show that neutrophil and macrophage driven acute dextran sulfate sodium (DSS) induced colitis was slightly more aggravated in BID-deficient mice, based on significantly increased weight loss compared to wild-type controls. Taken together, our data support a central role for FASL > FAS and BID in mouse neutrophil cell death and further underline the anti-inflammatory role of BID.

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss

PubMed Central

Wicki, Simone; Gurzeler, Ursina; Corazza, Nadia; Genitsch, Vera

2018-01-01

Neutrophils are key players in the early defense against invading pathogens. Due to their potent effector functions, programmed cell death of activated neutrophils has to be tightly controlled; however, its underlying mechanisms remain unclear. Fas ligand (FASL/CD95L) has been shown to induce neutrophil apoptosis, which is accelerated by the processing of the BH3-only protein BH3 interacting domain death agonist (BID) to trigger mitochondrial apoptotic events, and been attributed a regulatory role during viral and bacterial infections. Here, we show that, in accordance with previous works, mouse neutrophils underwent caspase-dependent apoptosis in response to FASL, and that this cell death was significantly delayed upon loss of BID. However, pan-caspase inhibition failed to protect mouse neutrophils from FASL-induced apoptosis and caused a switch to RIPK3-dependent necroptotic cell death. Intriguingly, such a switch was less evident in the absence of BID, particularly under inflammatory conditions. Delayed neutrophil apoptosis has been implicated in several auto-inflammatory diseases, including inflammatory bowel disease. We show that neutrophil and macrophage driven acute dextran sulfate sodium (DSS) induced colitis was slightly more aggravated in BID-deficient mice, based on significantly increased weight loss compared to wild-type controls. Taken together, our data support a central role for FASL > FAS and BID in mouse neutrophil cell death and further underline the anti-inflammatory role of BID. PMID:29495595

Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.

PubMed

Balboni, Gianfranco; Fiorini, Stella; Baldisserotto, Anna; Trapella, Claudio; Sasaki, Yusuke; Ambo, Akihiro; Marczak, Ewa D; Lazarus, Lawrence H; Salvadori, Severo

2008-08-28

Some reference opioids containing the Dmt-Tic pharmacophore, especially the delta agonists H-Dmt-Tic-Gly-NH-Ph (1) and H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid (4) (UFP-512) were evaluated for the influence of the substitution of Gly with aspartic acid, its chirality, and the importance of the -NH-Ph and N(1)H-Bid hydrogens in the inductions of delta agonism. The results provide the following conclusions: (i) Asp increases delta selectivity by lowering the mu affinity; (ii) -NH-Ph and N(1)H-Bid nitrogens methylation transforms the delta agonists into delta antagonists; (iii) the substitution of Gly with L-Asp/D-Asp in the delta agonist H-Dmt-Tic-Gly-NH-Ph gave delta antagonists; the same substitution in the delta agonist H-Dmt-Tic-NH-CH2-Bid yielded more selective agonists, H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid and H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid; (iv) L-Asp seems important only in functional bioactivity, not in receptor affinity; (v) H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid(N(1)-Me) (10) evidenced analgesia similar to 4, which was reversed by naltrindole only in the tail flick. 4 and 10 had opposite behaviours in mice; 4 caused agitation, 10 gave sedation and convulsions.

Minority business bidding for local government contracts: the complexity of availability.

PubMed

Bangs, Ralph L; Murrell, Audrey; Constance-Huggins, Monique

2007-01-01

While minority-business enterprises (MBEs) have gained some access to local government contracts during the last three decades, these firms continue to receive a small share of local government contract spending relative to the number of available firms. Researchers have suggested two general explanations for the low representation of MBEs in contract awards: (1) lack of qualifications and capacity among MBEs, and (2) public and private discrimination against MBEs in contracting processes. This study on prime contract opportunities in a Northern central city and county with a large minority population finds that low bid rates greatly contribute to the low MBE shares of prime contracts and that bidding is reduced by both local government processes and characteristics of the firms. Some implications of these findings are that local governments need to: (1) monitor MBE shares of prime contract bids by size of contract and use share of bids as one measure of program and organizational effectiveness; (2) identify MBEs that are qualified for prime contracts and encourage and help interested firms to submit competitive bids; and (3) ensure that local government policies and practices do not diminish access to information about prime contract opportunities for qualified and interested minority firms. Another implication is that bidders lists should not be a primary basis for determining MBE availability, since many qualified and interested MBEs do not bid because of perceived barriers in local government.

77 FR 19835 - Grant of Individual Exemption Involving BlackRock, Inc. and Its Investment Advisory, Investment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... implicit U.S. Government guarantee as opposed to an explicit U.S. Government guarantee, (a) the BlackRock... 2510.3-101(i) which is accompanied by an implicit U.S. Government guarantee as opposed to an explicit U... or any member of the ECO Function in the performance of his or her duties; 6. The ECO is responsible...

In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits.

PubMed

Sheppard, John D; Cockrum, Paul C; Justice, Angela; Jasek, Mark C

2018-05-14

Little is known of the ocular distribution characteristics of currently branded non-steroidal anti-inflammatory drugs (NSAIDs) in the United States. This study was designed to predict the ocular bioavailability characteristics in humans using Dutch Belted rabbits as a surrogate. Commercially available, topically-applied NSAIDs containing bromfenac or nepafenac/amfenac were evaluated. 126 healthy adult Dutch Belted rabbits were randomly assigned to three treatment cohorts (BromSite ® twice daily [BID] in the right eye, BromSite ® once daily [QD] in the right eye, Prolensa ® QD in the right eye and Ilevro™ QD in the left eye) and 7 post-dosing time points (0.5, 1, 2, 4, 8, 12, 24 h after final instillation). The study eyes received 40 µL of the assigned drug for a consecutive 9 days. Samples of aqueous humor, iris-ciliary body, choroid, sclera, and retina were harvested from the study eyes at the assigned time point after the last dose on the 9th day. NSAID content in ocular tissues was analyzed using high-performance liquid chromatography (HPLC), and area under the curve (AUC 0.5-24h ), maximum concentration (C max ), and time to maximum concentration (T max ) were determined. Peak NSAID concentrations were reached within 1-3 h in the anterior segment and within 1-3 h in the posterior segment after last dose. Throughout the ocular tissues, both AUC and C max for BromSite ® (BID and QD) were consistently higher than respective NSAID concentrations of Prolensa ® QD and Ilevro ® QD. When comparing BromSite ® BID to QD, the BID regimen produced generally higher but statistically similar bromfenac concentrations throughout the ocular tissues except in the aqueous humor and iris-ciliary body, where the AUC BID was statistically significantly higher with BromSite ® BID. As a surrogate to human ocular bioavailability, BromSite ® demonstrated significantly greater NSAID compared to Prolensa ® QD and Ilevro ® QD. The DuraSite ® component of BromSite ® appears to enhance ocular penetration throughout both anterior and posterior tissues. Sun Pharmaceutical Industries Ltd.

46 CFR Sec. 2 - Use of contract for competitive bid and negotiated price awards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 2 Use of contract for competitive bid and negotiated price awards. (a) The NSA-LUMPSUMREP Contract is a Master form of fixed price contract and is applicable to... awarded under the NSA-LUMPSUMREP Contract must be awarded upon the basis of competitive bids. Revised...

46 CFR Sec. 2 - Use of contract for competitive bid and negotiated price awards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 2 Use of contract for competitive bid and negotiated price awards. (a) The NSA-LUMPSUMREP Contract is a Master form of fixed price contract and is applicable to... awarded under the NSA-LUMPSUMREP Contract must be awarded upon the basis of competitive bids. Revised...

46 CFR Sec. 2 - Use of contract for competitive bid and negotiated price awards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 2 Use of contract for competitive bid and negotiated price awards. (a) The NSA-LUMPSUMREP Contract is a Master form of fixed price contract and is applicable to... awarded under the NSA-LUMPSUMREP Contract must be awarded upon the basis of competitive bids. Revised...

46 CFR Sec. 2 - Use of contract for competitive bid and negotiated price awards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 2 Use of contract for competitive bid and negotiated price awards. (a) The NSA-LUMPSUMREP Contract is a Master form of fixed price contract and is applicable to... awarded under the NSA-LUMPSUMREP Contract must be awarded upon the basis of competitive bids. Revised...

23 CFR 635.114 - Award of contract and concurrence in award.

Code of Federal Regulations, 2014 CFR

2014-04-01

... STD in accordance with § 635.110. Award shall be within the time established by the STD and subject to the prior concurrence of the Division Administrator. (b) The STD shall formally request concurrence by.... (c) Following the opening of bids, the STD shall examine the unit bid prices of the apparent low bid...

23 CFR 635.114 - Award of contract and concurrence in award.

Code of Federal Regulations, 2013 CFR

2013-04-01

... STD in accordance with § 635.110. Award shall be within the time established by the STD and subject to the prior concurrence of the Division Administrator. (b) The STD shall formally request concurrence by.... (c) Following the opening of bids, the STD shall examine the unit bid prices of the apparent low bid...

23 CFR 635.114 - Award of contract and concurrence in award.

Code of Federal Regulations, 2011 CFR

2011-04-01

... STD in accordance with § 635.110. Award shall be within the time established by the STD and subject to the prior concurrence of the Division Administrator. (b) The STD shall formally request concurrence by.... (c) Following the opening of bids, the STD shall examine the unit bid prices of the apparent low bid...

23 CFR 635.114 - Award of contract and concurrence in award.

Code of Federal Regulations, 2012 CFR

2012-04-01

... STD in accordance with § 635.110. Award shall be within the time established by the STD and subject to the prior concurrence of the Division Administrator. (b) The STD shall formally request concurrence by.... (c) Following the opening of bids, the STD shall examine the unit bid prices of the apparent low bid...

78 FR 42820 - Agency Information Collection (Caution to Bidders-Bid Envelopes) Activities Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... or a Copy of the Submission Contact: Crystal Rennie, Enterprise Records Service (005R1B), Department of Veterans Affairs, 810 Vermont Avenue NW., Washington, DC 20420, (202) 632-7492 or email: crystal... mail or packages received and to ensure the bids are delivered to the proper bid opening room on time...

78 FR 34667 - Notice of Single Family Loan Sales (SFLS 2013-2)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... submitted and determine the successful bid, in terms of the best value to HUD, in its sole and absolute... Sales (SFLS 2013-2) AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner... describes the bidding process for the sale and certain persons who are ineligible to bid. This is the second...

78 FR 14350 - Notice of Single Family Loan Sales (SFLS 2013-1)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

... determine the successful bid, in terms of the best value to HUD, in its sole and absolute discretion. If a... Sales (SFLS 2013-1) AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner... describes the bidding process for the sale and describes certain persons who are ineligible to bid. This...

46 CFR Sec. 2 - Use of contract for competitive bid and negotiated price awards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ship repair work awarded as a result of competitive bidding or negotiation. As a general rule all work... shall be rejected. If the ship's availability permits a new Invitation for Bids for the work in question... the accomplishment of work under the NSA-LUMPSUMREP Contract will be permitted in lieu of competitive...

78 FR 12397 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Granting Approval to Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

...''), that is priced more aggressively than the Protected National Best Bid or Offer (``Protected NBBO'') \\10..., generally, the Protected Bid and Protected Offer, and the national best bid (``NBB'') and national best... automatic execution. In such case, the Exchange states that the Protected NBBO would be the best-priced...

48 CFR 811.104-74 - Bid evaluation and award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 811.104-74 Bid evaluation and award. (a) A bid offering products that differ from brand name products referenced in a “brand name or equal” purchase description must be considered for award if the contracting officer determines in accordance with the terms of the clause at 852.211-73, Brand name or equal, that the...

47 CFR 1.2204 - Applications to participate in competitive bidding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... corporation, the name and address of the corporate office and the name and title of an officer or director. If..., if applicable. (2) The identity of the person(s) authorized to take binding action in the bidding on... submit reverse auction bids: (i) The identity of the station and its television channel; (ii) Whether it...

78 FR 62658 - Proposed Information Collection; National Park Service Leasing Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... proposals or bids by parties interested in applying for a lease. The regulations also require that the... interests. We collect Information from anyone who wishes to submit a bid or proposal to lease a property... Proposals, Bids, Qualifications Complex 10 10 40 400 Simple 10 10 8 80 Requests to Sublet/Assign Lease...

47 CFR 27.1103 - 2000-2020 MHz and 2180-2200 MHz bands subject to competitive bidding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false 2000-2020 MHz and 2180-2200 MHz bands subject... MHz, 2000-2020 MHz, and 2180-2200 MHz bands Licensing and Competitive Bidding Provisions § 27.1103 2000-2020 MHz and 2180-2200 MHz bands subject to competitive bidding. Mutually exclusive initial...

Selected Laws Relating to the Construction and Repair of Public School Facilities in North Carolina.

ERIC Educational Resources Information Center

North Carolina State Dept. of Public Instruction, Raleigh.

Schools in North Carolina are governed by numerous laws pertaining to construction and repair. A selection of these laws is presented. Financial concerns constitute the bulk of these statutes, covering areas such as bids (financial outlay, advertisement, rejecting bids, and withdrawing bids); sources of state funds; the selling or buying of school…

48 CFR 552.236-73 - Basis of Award-Construction Contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... applicable number of units shown on the bid form) plus (2) all options designated to be evaluated. The... applicable number of units shown on the bid form) plus (2) those alternates in the order of priority listed.... For example, when the amount available is $100,000 and a bidder's base bid is $85,000, with its...

42 CFR 414.412 - Submission of bids under a competitive bidding program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... D of this part. (c) Furnishing of items. A bid must include all costs related to furnishing an item... capital, stock or profits of another supplier; (ii) A controlling interest exists if one or more of owners... controlling interest and each supplier which has an ownership or controlling interest in it. (3) Commonly...

48 CFR 22.1014 - Delay over 60 days in bid opening or commencement of work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Delay over 60 days in bid... ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1014 Delay over 60 days in bid opening or commencement of work. If a...

48 CFR 32.405 - Applying Pub. L. 85-804 to advance payments under sealed bid contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... advance payments under sealed bid contracts. 32.405 Section 32.405 Federal Acquisition Regulations System... Non-Commercial Items 32.405 Applying Pub. L. 85-804 to advance payments under sealed bid contracts. (a... provisions of law relating to contracts, as explained in 50.101-1(a), also include making advance payments...

75 FR 13212 - Proposed Information Collection (Caution to Bidders-Bid Envelopes) Activity: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... (Caution to Bidders--Bid Envelopes) Activity: Comment Request AGENCY: Office of Acquisition and Logistics... comment in response to the notice. This notice solicits comments on the information needed to identify bid...: Under the PRA of 1995 (Public Law 104-13; 44 U.S.C. 3501-3521), Federal agencies must obtain approval...

Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin/clavulanate potassium (Augmentin) for treatment of acute otitis media in children.

PubMed

Hoberman, A; Paradise, J L; Burch, D J; Valinski, W A; Hedrick, J A; Aronovitz, G H; Drehobl, M A; Rogers, J M

1997-05-01

To compare the safety and efficacy, in treating acute otitis media (AOM) in children, of a new formulation of amoxicillin/clavulanate potassium (Augmentin) oral suspension providing 45/6.4 mg/kg/day and administered twice daily (bid) for 5 and 10 days, respectively, with the safety and efficacy of the original formulation providing 40/10 mg/kg/day and administered three times daily (tid) for 10 days. Eight hundred sixty-eight children ages 2 months to 12 years with AOM were randomly assigned to one of the three treatment groups. Stringent criteria were used for the diagnosis of AOM and for determinations of "cure" and "improvement." Subjects were reexamined on Days 12 to 14 and 32 to 38. Among subjects whose treatment and follow-up conformed fully to protocol, the proportion of treatment successes (clinically cured or improved) on Days 12 to 14 was 78.8% (149 of 189) in the tid 10-day group, 86.5% (154 of 178) in the bid 10-day group and 71.1% (140 of 197) in the bid 5-day group. Corresponding values on Days 32 to 38 were 64.2% (95 of 148) in the tid 10-day group, 63.1% (94 of 149) in the bid 10-day group and 57.8% (93 of 161) in the bid 5-day group. None of the differences between the tid 10-day regimen and either of the 2 bid regimens were statistically significant, but the bid 10-day regimen was significantly more effective than the bid 5-day regimen in younger subjects. In the study population as a whole, results were similar to those in per protocol subjects. Overall the incidence of protocol-defined diarrhea was 26.7% (74 of 277) in the tid 10-day group, compared with 9.6% (27 of 280) in the bid 10-day group (P < 0.0001) and 8.7% (25 of 286) in the bid 5-day group (P < 0.0001). In comparison with the original formulation of Augmentin administered tid for 10 days in the treatment of AOM in children, the new formulation administered bid for 10 days provides at least equivalent efficacy and causes substantially less diarrhea. Administration for 5 days appears not to provide equivalent efficacy, but the difference appears limited to younger children and the margin of difference is small.

A phase I trial of the human double minute 2 inhibitor (MK-8242) in patients with refractory/recurrent acute myelogenous leukemia (AML)

PubMed Central

Ravandi, Farhad; Gojo, Ivana; Patnaik, Mrinal M.; Minden, Mark D.; Kantarjian, Hagop; Johnson-Levonas, Amy O.; Fancourt, Craig; Lam, Raymond; Jones, Mary Beth; Knox, Clayton D.; Rose, Shelonitda; Patel, Payal Shah; Tibes, Raoul

2017-01-01

Objective Evaluate safety/tolerability/efficacy of MK-8242 in subjects with refractory/recurrent AML. Methods MK-8242 was dosed p.o. QD (30–250 mg) or BID (120–250 mg) for 7on/7off in 28-day cycle. Dosing was modified to 7on/14off, in 21-day cycle (210 or 300 mg BID). Results 26 subjects enrolled (24 evaluable for response); 5/26 discontinued due to AEs. There were 7 deaths; 1 (fungal pneumonia due to marrow aplasia) possibly drug-related. With the 7on/7off regimen, 2 subjects had DLTs in the 250 mg BID group (both bone marrow failure and prolonged cytopenia). With the 7on/14off, no DLTs were observed in 210 mg BID or 300 mg BID (doses >300 mg not tested). Best responses were: 1/24 PR (11 weeks;120 mg QD, 7on/7off); 1/24 CRi (2 weeks;210 mg BID, 7on/14off); 1/24 morphologic leukemia-free state (4 weeks; 250 mg BID, 7on/7off). PK on Day7 at 210 mg BID revealed AUC0-12hr 8.7 μM*hr, Cmax 1.5 μM (n=5, Tmax, 2–6 hr), T1/2 7.9 hr, CLss/F 28.8 L/hr, and Vss/F 317 L. Conclusions The 7on/14off regimen showed a more favorable safety profile; no MTD was established. Efficacy was seen using both regimens providing impetus for further study of HDM2 inhibitors in subjects with AML. PMID:27544076

A Phase III, Randomized, Controlled Trial of Apremilast in Patients with Psoriatic Arthritis: Results of the PALACE 2 Trial.

PubMed

Cutolo, Maurizio; Myerson, Gary E; Fleischmann, Roy M; Lioté, Frédéric; Díaz-González, Federico; Van den Bosch, Filip; Marzo-Ortega, Helena; Feist, Eugen; Shah, Kamal; Hu, ChiaChi; Stevens, Randall M; Poder, Airi

2016-09-01

Apremilast, an oral phosphodiesterase 4 inhibitor, downregulates intracellular inflammatory mediator synthesis by elevating cyclic adenosine monophosphate levels. The PALACE 2 trial evaluated apremilast efficacy and safety in patients with active psoriatic arthritis (PsA) despite prior conventional disease-modifying antirheumatic drugs and/or biologic therapy. Eligible patients were randomized (1:1:1) to placebo, apremilast 20 mg BID, or apremilast 30 mg BID. At Week 16, patients with swollen and tender joint count improvement < 20% entered early escape, with placebo patients rerandomized (1:1) to apremilast 20 mg BID or 30 mg BID while apremilast patients continued on their initial apremilast dose. At Week 24, patients remaining on placebo were rerandomized to apremilast 20 mg BID or 30 mg BID. The primary endpoint was the proportion of patients achieving > 20% improvement in American College of Rheumatology response criteria (ACR20) at Week 16. In the intent-to-treat population (N = 484), ACR20 at Week 16 was achieved by more patients receiving apremilast 20 mg BID [37.4% (p = 0.0002)] and 30 mg BID [32.1% (p = 0.0060)] versus placebo (18.9%). Clinically meaningful improvements in signs and symptoms of PsA, physical function, and psoriasis were observed with apremilast through Week 52. The most common adverse events were diarrhea, nausea, headache, and upper respiratory tract infection. Diarrhea and nausea generally occurred early and usually resolved spontaneously with continued treatment. Laboratory abnormalities were infrequent and transient. Apremilast demonstrated clinical improvements in PsA for up to 52 weeks, including signs and symptoms, physical function, and psoriasis. No new safety signals were observed. ClinicalTrials.gov identifier: NCT01212757.

Outsourcing's Potential in Higher Education.

ERIC Educational Resources Information Center

Robinson, Robert J.

1991-01-01

Reasons why institutions of higher education might choose to acquire computer services from off-campus suppliers are identified and include the difficulty of maintaining a qualified technical systems group. The importance of careful management oversight from contract bidding to ongoing performance monitoring is stressed. (DB)

Construction Management.

ERIC Educational Resources Information Center

Abbott, James F.

This article provides a detailed discussion of a team approach to building that involves a construction manager, an architect, and a contractor. Bidding methods are outlined; the major components in construction management -- value engineering and fast track scheduling -- and the use of performance specifications are discussed. The construction…

The wisdom of the crowd playing The Price Is Right.

PubMed

Lee, Michael D; Zhang, Shunan; Shi, Jenny

2011-07-01

In The Price Is Right game show, players compete to win a prize, by placing bids on its price. We ask whether it is possible to achieve a "wisdom of the crowd" effect, by combining the bids to produce an aggregate price estimate that is superior to the estimates of individual players. Using data from the game show, we show that a wisdom of the crowd effect is possible, especially by using models of the decision-making processes involved in bidding. The key insight is that, because of the competitive nature of the game, what people bid is not necessarily the same as what they know. This means better estimates are formed by aggregating latent knowledge than by aggregating observed bids. We use our results to highlight the usefulness of models of cognition and decision-making in studying the wisdom of the crowd, which are often approached only from non-psychological statistical perspectives.

Network analysis of online bidding activity

NASA Astrophysics Data System (ADS)

Yang, I.; Oh, E.; Kahng, B.

2006-07-01

With the advent of digital media, people are increasingly resorting to online channels for commercial transactions. The online auction is a prototypical example. In such online transactions, the pattern of bidding activity is more complex than traditional offline transactions; this is because the number of bidders participating in a given transaction is not bounded and the bidders can also easily respond to the bidding instantaneously. By using the recently developed network theory, we study the interaction patterns between bidders (items) who (that) are connected when they bid for the same item (if the item is bid by the same bidder). The resulting network is analyzed by using the hierarchical clustering algorithm, which is used for clustering analysis for expression data from DNA microarrays. A dendrogram is constructed for the item subcategories; this dendrogram is compared to a traditional classification scheme. The implication of the difference between the two is discussed.

Managing Wind Power Uncertainty Through Strategic Reserve Purchasing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Du, Ershun; Zhang, Ning; Kang, Chongqing

With the rapidly increasing penetration of wind power, wind producers are becoming increasingly responsible for the deviation of the wind power output from the forecast. Such uncertainty results in revenue losses to the wind power producers (WPPs) due to penalties in ex-post imbalance settlements. This paper explores the opportunities available for WPPs if they can purchase or schedule some reserves to offset part of their deviation rather than being fully penalized in the real time market. The revenue for WPPs under such mechanism is modeled. The optimal strategy for managing the uncertainty of wind power by purchasing reserves to maximizemore » the WPP's revenue is analytically derived with rigorous optimality conditions. The amount of energy and reserves that should be bid in the market are explicitly quantified by the probabilistic forecast and the prices of the energy and reserves. A case study using the price data from ERCOT and wind power data from NREL is performed to verify the effectiveness of the derived optimal bidding strategy and the benefits of reserve purchasing. Additionally, the proposed bidding strategy can also reduce the risk of variations on WPP's revenue.« less

Improving Agent Bidding in Power Stock Markets through a Data Mining Enhanced Agent Platform

NASA Astrophysics Data System (ADS)

Chrysopoulos, Anthony C.; Symeonidis, Andreas L.; Mitkas, Pericles A.

Like in any other auctioning environment, entities participating in Power Stock Markets have to compete against other in order to maximize own revenue. Towards the satisfaction of their goal, these entities (agents - human or software ones) may adopt different types of strategies - from na?ve to extremely complex ones - in order to identify the most profitable goods compilation, the appropriate price to buy or sell etc, always under time pressure and auction environment constraints. Decisions become even more difficult to make in case one takes the vast volumes of historical data available into account: goods’ prices, market fluctuations, bidding habits and buying opportunities. Within the context of this paper we present Cassandra, a multi-agent platform that exploits data mining, in order to extract efficient models for predicting Power Settlement prices and Power Load values in typical Day-ahead Power markets. The functionality of Cassandra is discussed, while focus is given on the bidding mechanism of Cassandra’s agents, and the way data mining analysis is performed in order to generate the optimal forecasting models. Cassandra has been tested in a real-world scenario, with data derived from the Greek Energy Stock market.

42 CFR 423.272 - Review and negotiation of bid and approval of plans submitted by potential Part D sponsors.

Code of Federal Regulations, 2011 CFR

2011-10-01

... submitted by potential Part D sponsors. 423.272 Section 423.272 Public Health CENTERS FOR MEDICARE... and negotiation of bid and approval of plans submitted by potential Part D sponsors. (a) Review and...) Substantial differences between bids—(i) General. CMS approves a bid only if it finds that the benefit package...

42 CFR 423.272 - Review and negotiation of bid and approval of plans submitted by potential Part D sponsors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... submitted by potential Part D sponsors. 423.272 Section 423.272 Public Health CENTERS FOR MEDICARE... and negotiation of bid and approval of plans submitted by potential Part D sponsors. (a) Review and...) Substantial differences between bids—(i) General. CMS approves a bid only if it finds that the benefit package...

42 CFR 423.272 - Review and negotiation of bid and approval of plans submitted by potential Part D sponsors.

Code of Federal Regulations, 2013 CFR

2013-10-01

... submitted by potential Part D sponsors. 423.272 Section 423.272 Public Health CENTERS FOR MEDICARE... Approval § 423.272 Review and negotiation of bid and approval of plans submitted by potential Part D... from the formulary. (3) Substantial differences between bids—(i) General. CMS approves a bid only if it...

32 CFR 644.545 - Form of invitation for bids and contract of sale.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Form of invitation for bids and contract of sale... (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Sale Procedure § 644.545 Form of invitation for bids and contract of sale. Sale contract forms will be prepared by the DE conducting the sale. ENG Form 571...

32 CFR 644.545 - Form of invitation for bids and contract of sale.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Form of invitation for bids and contract of sale... (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Sale Procedure § 644.545 Form of invitation for bids and contract of sale. Sale contract forms will be prepared by the DE conducting the sale. ENG Form 571...

10-MWe solar-thermal central-receiver pilot plant: collector subsystem foundation construction. Revision No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-12-18

Bid documents are provided for the construction of the collector subsystem foundation of the Barstow Solar Pilot Plant, including invitation to bid, bid form, representations and certifications, construction contract, and labor standards provisions of the Davis-Bacon Act. Instructions to bidders, general provisions and general conditions are included. Technical specifications are provided for the construction. (LEW)

77 FR 13142 - Notice of Realty Action: Modified-Competitive Sale of Public Land in Pahrump, Nye County, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... CFR 2711.3-1(f) and (g). Sealed bids will be presented for the sale parcel. Sealed-bid envelopes must.... Personal or company checks will not be accepted. The sealed-bid envelope shall also include a completed and... by presenting a birth certificate, passport, or naturalization papers. Failure to submit the above...

78 FR 12117 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Amending...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... designed to protect investors and the public interest. Granting Market Makers more time to request a review... addresses errors in series with zero or no bid. Specifically, the Exchange proposes replacing reference to ``series quoted no bid on the Exchange'' with ``series where the NBBO bid is zero.'' This is being done to...