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Sample records for bifocal contact lenses

  1. [Bifocal contact lenses as a correction method in presbyopia].

    PubMed

    Avetisov, S E; Rybakova, E G; Egorova, G B; Churkina, M N; Borodina, N V; Boev, V I

    2003-01-01

    A study aimed at assessing the efficiency of presbyopia correction by bifocal contact lenses (BCL) was undertaken; it envisaged a comprehensive evaluation of subjective data provided by patients and measurements of a number of functional parameters of the visual quality for far and near, including mono- and binocular measurements with BCL of different constructions versus a maximal sphero-cylindrical spectacle correction for far and for near. Soft Acuvue Bifocal BCL as well as soft and rigid BCL manufactured in the optical-and-mechanical laboratory of the Research Institute for Eye Disease of the Russian Academy of Medical Sciences and Russian-made and imported bifocal soft and rigid lenses, respectively, were made use of in the study. A reduced contrast sensitivity (mainly in high frequencies) to 7% with Russian-made BCL, to 12.5% with Acuvue Bifocal BCL, to 8.7% with monofocal BCL and to 13.4% with the "mono-vision" system was registered. A decreased visual working ability to 13% with soft bifocal Russian-made BCL, to 17.3% with Acuvue Bifocal BCL and to 20.7% with the "mono-vision" system was detected versus the spectacle correction. A reduction by 25% was noted in the stereoscopic vision indices with the "mono-vision" system. A study of sensitivity to dazzling did not show any statistically reliable differences between various correction types.

  2. Bifocal contact lenses: History, types, characteristics, and actual state and problems

    PubMed Central

    Toshida, Hiroshi; Takahashi, Kozo; Sado, Kazushige; Kanai, Atsushi; Murakami, Akira

    2008-01-01

    Since people who wear contact lenses (CL) often continue using CL even when they develop presbyopia, there are growing expectations for bifocal CL. To understand actual state and problems, history, types, and their characteristics are summarized in this review. Bifocal CL have a long history over 70 years. Recently, bifocal CL have achieved remarkable progress. However, there still is an impression that prescription of bifocal CL is not easy. It should also be remembered that bifocal CL have limits, including limited addition for near vision, as well as the effects of aging and eye diseases in the aged, such as dry eye, astigmatism, cataract, etc. Analysis of the long-term users of bifocal CL among our patients has revealed the disappearance of bifocal CL that achieved unsatisfactory vision and poor contrast compared with those provided by other types of CL. Changing the prescription up to 3 times for lenses of the same brand may be appropriate. Lenses that provide poor contrast sensitivity, suffer from glare, or give unsatisfactory vision have been weeded out. The repeated replacement of products due to the emergence of improved or new products will be guessed. PMID:19668441

  3. Simultaneous vision bifocal contact lenses: a comparative assessment of the in vitro optical performance.

    PubMed

    Young, G; Grey, C P; Papas, E B

    1990-05-01

    We measured the modulation transfer functions (MTF's) of five simultaneous vision bifocal contact lenses: center-near (Alges, University Optical Products), center-distance (BiSoft, CIBA Vision), diffractive rigid gas-permeable (Diffrax, Pilkington Barnes-Hind), diffractive hydrogel (Hydron Echelon, Allergan), and varifocal center-near (PS-45, G. Nissel). MTF's were measured at various aperture sizes (1 to 7 mm) and at a wavelength of 546 nm. The soft diffractive bifocal MTF's were measured at various wavelengths. The results tended to confirm previous theoretical calculations. The optical performance of the concentric designs was highly sensitive to variations in aperture size. The optical performance of both the rigid and soft diffractive lenses was largely (but not entirely) independent of aperture size. The varifocal lens was sensitive to changes in aperture size with respect to both optical quality and optimal focus.

  4. Reliability of power profiles measured on NIMO TR1504 (Lambda-X) and effects of lens decentration for single vision, bifocal and multifocal contact lenses

    PubMed Central

    Kim, Eon; Bakaraju, Ravi C.; Ehrmann, Klaus

    2015-01-01

    Purpose To evaluate the repeatability of power profiles measured on NIMO TR1504 (Lambda-X, Belgium) and investigate the effects of lens decentration on the power profiles for single vision (SV), bifocal (BF) and multifocal (MF) contact lenses. Methods Accuracy of the sphere power was evaluated using single vision BK-7 calibration glass lenses of six minus and six plus powers. Three SV and four BF/MF contact lenses – three lenses each, were measured five times to calculate the coefficients of repeatability (COR) of the instrument. The COR was computed for each chord position, lens design, prescription power and operator. One lens from each type was measured with a deliberate decentration up to ±0.5 mm in 0.1 mm steps. Results For all lenses, the COR varied across different regions of the half-chord position. In general, SV lenses showed lower COR compared to the BF/MF group lenses. There were no noticeable trends of COR between prescription powers for SV and BF/MF lenses. The shape of the power profiles was not affected when lenses were deliberately decentered for all SV and PureVision MF lenses. However, for Acuvue BF lenses, the peak to trough amplitude of the power profiles flattened up to 1.00 D. Conclusion The COR across the half-chord of the optic zone diameter was mostly within clinical relevance except for the central 0.5 mm half-chord position. COR were dependent on the lens type, whereby BF/MF group produced higher COR than SV lenses. The effects of deliberate decentration on the shape of power profiles were pronounced for lenses where the profiles had sharp transitions of power. PMID:26590009

  5. Image formation by bifocal lenses in a trilobite eye?

    PubMed

    Gál, J; Horváth, G; Clarkson, E N; Haiman, O

    2000-01-01

    In this work we report on a unique and ancient type of eye, in which the lower surface of the upper calcite lens units possessed an enigmatic central bulge making the dioptric apparatus similar to a bifocal lens. This eye belonged to the trilobite Dalmanitina socialis, which became extinct several hundred million years ago. As far as we know, image formation by bifocal lenses of this kind did/does not occur in any other ancient or modern animal visual system. We suggest that the function of these bifocal lenses may be to enable the trilobite to see simultaneously both very near (e.g. floating food particles and tiny preys) and far (e.g. sea floor, conspecifics, or approaching enemies) in the optical environment through the central and peripheral lens region, respectively. This was the only reasonable function we could find to explain the puzzling lens shape. We admit that it is not clear whether bifocality was necessary for the animal studied. We show that the misleading and accidental resemblance of an erroneous correcting lens surface (designed by René DesCartes in 1637 [DesCartes, R. (1637). Oeuvres de DesCartes. La Géometrie. Livre 2. pp. 134. J. Maire, Leyden] to the correcting interface in the compound Dalmanitina lens may be the reason why the earlier students of the Dalmanitina lens did not recognize its possible bifocality.

  6. Psychophysical Vision Simulation of Diffractive Bifocal and Trifocal Intraocular Lenses

    PubMed Central

    Brezna, Wolfgang; Lux, Kirsten; Dragostinoff, Nikolaus; Krutzler, Christian; Plank, Nicole; Tobisch, Rainer; Boltz, Agnes; Garhöfer, Gerhard; Told, Reinhard; Witkowska, Katarzyna; Schmetterer, Leopold

    2016-01-01

    Purpose The visual performance of monofocal, bifocal, and trifocal intraocular lenses was evaluated by human individuals using a vision simulator device. This allowed investigation of the visual impression after cataract surgery, without the need actually to implant the lenses. Methods The randomized, double-masked, three-way cross-over study was conducted on 60 healthy male and female subjects aged between 18 and 35 years. Visual acuity (Early Treatment Diabetic Retinopathy Study; ETDRS) and contrast sensitivity tests (Pelli-Robson) under different lighting conditions (luminosities from 0.14–55 cd/m2, mesopic to photopic) were performed at different distances. Results Visual acuity tests showed no difference for corrected distance visual acuity data of bi- and trifocal lens prototypes (P = 0.851), but better results for the trifocal than for the bifocal lenses at distance corrected intermediate (P = 0.021) and distance corrected near visual acuity (P = 0.044). Contrast sensitivity showed no differences between bifocal and trifocal lenses at the distant (P = 0.984) and at the near position (P = 0.925), but better results for the trifocal lens at the intermediate position (P = 0.043). Visual acuity and contrast sensitivity showed a strong dependence on luminosity (P < 0.001). Conclusions At all investigated distances and all lighting conditions, the trifocal lens prototype often performed better, but never worse than the bifocal lens prototype. Translational Relevance The vision simulator can fill the gap between preclinical lens development and implantation studies by providing information of the perceived vision quality after cataract surgery without implantation. This can reduce implantation risks and promotes the development of new lens concepts due to the cost effective test procedure. PMID:27777828

  7. Types of Contact Lenses

    MedlinePlus

    ... Consumer Devices Consumer Products Contact Lenses Types of Contact Lenses Share Tweet Linkedin Pin it More sharing ... Orthokeratology (Ortho-K) Decorative (Plano) Contact Lenses Soft Contact Lenses Soft contact lenses are made of soft, ...

  8. Obituary--rigid contact lenses.

    PubMed

    Efron, Nathan

    2010-10-01

    Scleral and corneal rigid lenses represented 100 per cent of the contact lens market immediately prior to the invention of soft lenses in the mid-1960s. In the United Kingdom today, rigid lenses comprise 2 per cent of all new lens fits. Low rates of rigid lens fitting are also apparent in 27 other countries which have recently been surveyed. Thus, the 1998 prediction of the author that rigid lenses--also referred to as 'rigid gas permeable' (RGP) lenses or 'gas permeable' (GP) lenses--would be obsolete by the year 2010 has essentially turned out to be correct. In this obituary, the author offers 10 reasons for the demise of rigid lens fitting: initial rigid lens discomfort; intractable rigid lens-induced corneal and lid pathology; extensive soft lens advertising; superior soft lens fitting logistics; lack of rigid lens training opportunities; redundancy of the rigid lens 'problem solver' function; improved soft toric and bifocal/varifocal lenses; limited uptake of orthokeratology; lack of investment in rigid lenses; and the emergence of aberration control soft lenses. Rigid lenses are now being fitted by a minority of practitioners with specialist skills/training. Certainly, rigid lenses can no longer be considered as a mainstream form of contact lens correction. May their dear souls (bulk properties) rest in peace.

  9. Contact Lenses for Vision Correction

    MedlinePlus

    ... Ophthalmologist Patient Stories Español Eye Health / Glasses & Contacts Contact Lenses Sections Contact Lenses for Vision Correction Proper ... to Know About Contact Lenses Colored Contact Lenses Contact Lenses for Vision Correction Written by: Kierstan Boyd ...

  10. Glasses and Contact Lenses

    MedlinePlus

    ... dientes Video: Getting an X-ray Glasses and Contact Lenses KidsHealth > For Kids > Glasses and Contact Lenses Print A A A What's in this ... together the way they should. But eyeglasses or contact lenses, also called corrective lenses, can help most ...

  11. Contact Lenses on Submarines

    DTIC Science & Technology

    2014-09-26

    NAVAL SUBMARINE MEDICAL RESEARCH LABORATORY SUBMARINE BASE, GROTON, CONN. REPORT NUMBER 1048 CONTACT LENSES ON SUBMARINES... CONTACT LENSES ON SUBMARINES by James F. Socks, CDR, MSC, USN NAVAL SUBMARINE MEDICAL RESEARCH LABORATORY REPORT NUMBER 1048 NAVAL MEDICAL RESEARCH...DRSCHLAB Approved for public release; distribution unlimited SUMMARY PAGE PROBLEM To determine the feasibility of wearing contact lenses aboard

  12. Bifocal, Electrically Switched Intraocular And Eyeglass Molecular Lenses

    NASA Astrophysics Data System (ADS)

    Kern, Seymour P.

    1986-05-01

    A bifocal electronic molecular lens is described which can be switched between two foci without any grossly visible change in displacement, geometry, temperature or chemical composition. The lens requires very little power to change focus (on the order of tens to hundreds of nanoamps) so that long-term remote operation is anticipated. The principle of operation is based upon electronic control of optical polarization through a birefringent lens. Switching of focus is accomplished by controlling the molecular alignment of a film of liquid crystal molecules and thereby selecting between two orthogonal optical polarizations (P1 and P2). Polarization P1 is associated with focal point S1 and P2 is associated with focal point S2 through the birefringent lens. A number of useful new products are made possible by this lens. Specifically discussed are an electronic intraocular lens and electronic eyeglasses, both of which can be powered independently.

  13. Soft contact lenses

    PubMed Central

    Sutherland, R. L.; VanLeeuwen, Wm. N.

    1972-01-01

    A series of 55 patients were fitted with a new type of hydrophilic soft contact lens. These were found more comfortable than hard contact lenses and they had a protective and pain-relieving action in cases of chronic corneal disease. Vision was not as good as with hard contact lenses and a greater potential danger of infection was found. They are preferred by many patients despite the noticeable thick edge and the difficulty of obtaining an identical replacement. PMID:5042887

  14. Contact Lenses in the Laboratory.

    ERIC Educational Resources Information Center

    Kingston, David W.

    1981-01-01

    Summarizes results of a three-item questionnaire returned by 43 Michigan institutions expressing views on wearing contact lenses in chemical laboratories. Questions focused on eye protection, type of protection, and use of contact lenses. (SK)

  15. Evaluating Optical Quality of a Bifocal Soft Contact Lens in Near Vision Using a Shack-Hartmann Wavefront Aberrometer

    NASA Astrophysics Data System (ADS)

    Hirohara, Yoko; Mihashi, Toshifumi; Suzaki, Asaki; Kuroda, Teruhito; Kelly, Jennifer Elise; Maeda, Naoyuki; Fujikado, Takashi

    2006-09-01

    To assess optical characteristics of bifocal soft contact lenses (BCLs) in use, we measured wavefront aberrations of human eyes, of eyes with a monofocal soft contact lens (MCL), and of eyes with a BCL. Modulation transfer functions (MTFs), Strehl ratios, and simulated images for far and near vision were produced with the measured aberrations. High order aberrations of subject 1 were significantly smaller than those of subject 2 (t-test, P = 0.001). We found that wearing the BCL improved the optical quality of an eye in subject 1, expressed as the horizontal MTF from 2 to 48 cycles per degree (cpd) for near vision and the Strehl ratio (t-test, P = 0.009 for Strehl ratio). But we did not find the same effect in subject 2. This difference may be due to the difference in the aberrations of the eyes of the two subjects.

  16. Clinical comparison of patient outcomes following implantation of trifocal or bifocal intraocular lenses: a systematic review and meta-analysis

    PubMed Central

    Shen, Zeren; Lin, Yuchen; Zhu, Yanan; Liu, Xin; Yan, Jie; Yao, Ke

    2017-01-01

    To assess the visual effects of trifocal intraocular lenses (IOLs) compared to bifocal IOLs in cataract surgery, a meta-analysis of prospective comparative clinical trials (including 4 randomized controlled trials and 4 cohorts) was conducted. The defocus curves showed a better distance-corrected intermediate visual acuity (VA) for the trifocal group (MD −0.07; 95% CI, −0.10 to −0.05; p < 0.00001), while the VA outcomes showed no significant difference in distance VA (MD −0.03; 95% CI, −0.06 to 0.01; p = 0.13 for uncorrected distance VA and MD −0.00; 95% CI, −0.01 to 0.01; p = 0.78 for distance-corrected distance VA), near VA (MD −0.01; 95% CI, −0.07 to 0.04; p = 0.68 for uncorrected near VA and MD −0.01; 95% CI, −0.06 to 0.04; p = 0.66 for distance-corrected near VA) or refraction between the two groups. Contrast sensitivity and subjective visual quality yielded less conclusive results. Overall, a patient may achieve better intermediate VA with a trifocal IOL than with a bifocal IOL without any adverse effect on distance or near VA. The findings on contrast sensitivity and subjective visual quality were heterogeneous, with no clear results favoring either option.

  17. Contact lenses for infant aphakia.

    PubMed Central

    Amaya, L G; Speedwell, L; Taylor, D

    1990-01-01

    We prospectively studied for three years the optical correction by contact lenses of 83 aphakic infants (141 eyes) who generally also had systemic and other ocular anomalies: 85% of the patients tolerated the lens wear for the whole study period. Complications occurred in 46 eyes and led to cessation of lens wear in two cases. Ten patients abandoned the lenses for other reasons. Thirty-four eyes needed subsequent intraocular surgery, mostly minor, and nine patients had strabismus surgery. Contact lenses are a versatile, safe, successful, and cost effective treatment for aphakia in infancy against which, before their widespread introduction for primary optical correction of infant aphakia, other methods of aphakic treatment need to be compared. PMID:2322512

  18. Impact of contact lens zone geometry and ocular optics on bifocal retinal image quality

    PubMed Central

    Bradley, Arthur; Nam, Jayoung; Xu, Renfeng; Harman, Leslie; Thibos, Larry

    2014-01-01

    Purpose To examine the separate and combined influences of zone geometry, pupil size, diffraction, apodisation and spherical aberration on the optical performance of concentric zonal bifocals. Methods Zonal bifocal pupil functions representing eye + ophthalmic correction were defined by interleaving wavefronts from separate optical zones of the bifocal. A two-zone design (a central circular inner zone surrounded by an annular outer-zone which is bounded by the pupil) and a five-zone design (a central small circular zone surrounded by four concentric annuli) were configured with programmable zone geometry, wavefront phase and pupil transmission characteristics. Using computational methods, we examined the effects of diffraction, Stiles Crawford apodisation, pupil size and spherical aberration on optical transfer functions for different target distances. Results Apodisation alters the relative weighting of each zone, and thus the balance of near and distance optical quality. When spherical aberration is included, the effective distance correction, add power and image quality depend on zone-geometry and Stiles Crawford Effect apodisation. When the outer zone width is narrow, diffraction limits the available image contrast when focused, but as pupil dilates and outer zone width increases, aberrations will limit the best achievable image quality. With two-zone designs, balancing near and distance image quality is not achieved with equal area inner and outer zones. With significant levels of spherical aberration, multi-zone designs effectively become multifocals. Conclusion Wave optics and pupil varying ocular optics significantly affect the imaging capabilities of different optical zones of concentric bifocals. With two-zone bifocal designs, diffraction, pupil apodisation spherical aberration, and zone size influence both the effective add power and the pupil size required to balance near and distance image quality. Five-zone bifocal designs achieve a high degree of

  19. Perceived image quality with simulated segmented bifocal corrections

    PubMed Central

    Dorronsoro, Carlos; Radhakrishnan, Aiswaryah; de Gracia, Pablo; Sawides, Lucie; Marcos, Susana

    2016-01-01

    Bifocal contact or intraocular lenses use the principle of simultaneous vision to correct for presbyopia. A modified two-channel simultaneous vision simulator provided with an amplitude transmission spatial light modulator was used to optically simulate 14 segmented bifocal patterns (+ 3 diopters addition) with different far/near pupillary distributions of equal energy. Five subjects with paralyzed accommodation evaluated image quality and subjective preference through the segmented bifocal corrections. There are strong and systematic perceptual differences across the patterns, subjects and observation distances: 48% of the conditions evaluated were significantly preferred or rejected. Optical simulations (in terms of through-focus Strehl ratio from Hartmann-Shack aberrometry) accurately predicted the pattern producing the highest perceived quality in 4 out of 5 patients, both for far and near vision. These perceptual differences found arise primarily from optical grounds, but have an important neural component. PMID:27895981

  20. [Use of rigid gas permeable contact lenses].

    PubMed

    Habela, M

    1992-01-01

    By application of contact lenses destined for a extended wearing, for preservation of a normal structure and metabolism of the cornea a considerable permeability of the contact lens for oxygen is necessary (Dk/L 75-80). The actually most popular in the world soft contact lenses have no such parameters. The application of rigid lenses produced from materials of high permeability for oxygen enables the extended wearing without substantial disturbances of the corneal metabolism. The paper presents a new generation of fluoro-silicone acrylates used for the production of contact lenses permeable for oxygen. Discussed are the problems connected with the adjusting of these lenses, their tolerance and influence on the corneal metabolism.

  1. [Correction of keratoconus with soft contact lenses].

    PubMed

    Koos, D; Bitea, M J

    1989-01-01

    The authors present their experience in using soft contact lenses in 33 eyes with keratoconus (18 patients). Adaptation was possible only when the doctor-patient collaboration was good. Visual acuity (VA) of 0.4-1 was obtained in 85% cases versus 42.5% when glasses were used. In the period under observation no case of VA decrease was recorded. The subjects tolerated well the contact lenses. The specialty literature contains data indicating not only the optical role of the contact lenses but also their therapeutic, tectorial role.

  2. Tear exchange and contact lenses: a review.

    PubMed

    Muntz, Alex; Subbaraman, Lakshman N; Sorbara, Luigina; Jones, Lyndon

    2015-01-01

    Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses.

  3. Tear exchange and contact lenses: A review

    PubMed Central

    Muntz, Alex; Subbaraman, Lakshman N.; Sorbara, Luigina; Jones, Lyndon

    2015-01-01

    Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses. PMID:25575892

  4. Dynamic contact angle analysis of silicone hydrogel contact lenses.

    PubMed

    Read, Michael Leonard; Morgan, Philip Bruce; Kelly, Jeremiah Michael; Maldonado-Codina, Carole

    2011-07-01

    Contact angle measurements are used to infer the clinical wetting characteristics of contact lenses. Such characterization has become more commonplace since the introduction of silicone hydrogel contact lens materials, which have been associated with reduced in vivo wetting due to the inclusion of siloxane-containing components. Using consistent methodology and a single investigator, advancing and receding contact angles were measured for 11 commercially available silicone hydrogel contact lens types with a dynamic captive bubble technique employing customized, fully automated image analysis. Advancing contact angles were found to range between 20° and 72° with the lenses falling into six statistically discrete groupings. Receding contact angles fell within a narrower range, between 17° and 22°, with the lenses segregated into three groups. The relationship between these laboratory measurements and the clinical performance of the lenses requires further investigation.

  5. Hydrogel polymerization in microgravity for contact lenses

    NASA Astrophysics Data System (ADS)

    Shcherbakova, Oksana; Kostarev, Konstantin; Kondyurin, Alexey

    Contact lenses become widely used for vision correction. The modern contact lenses made of polymer materials have to satisfy a number of requirements: biocompatibility and non-toxicity, low elastic module, high oxygen permeability, good wettability, mechanical strength and stable shape. To following all these requirements, special polymer compositions and polymerization techniques are in development. One of the unique technology is based on polymerization process in microgravity. The synthesis of the polymer structures proceeds in low concentration solution and Earth gravity has a great influence on the polymerization kinetics and final properties of the gel. The microgravity conditions give a possibility to get a regular polymer network with specific macromolecular structure. The experiments on board of space station and theoretical models of the polymerization processes are considered for contact lenses application.

  6. Disposable hydrogel contact lenses for extended wear.

    PubMed

    Donshik, P; Weinstock, F J; Wechsler, S; Asbell, P; Atwood, J; Davis, H; Farkas, B; Farris, R L; Gruber, E; Hartstein, J

    1988-01-01

    Nine ophthalmologists and nine optometrists conducted a premarket study of the Acuvue disposable contact lens manufactured by Vistakon, Inc. Of the 812 patients offered the lens, 733 accepted it and were enrolled in the study. These patients were fitted with the lens and followed for a period of 8 months. Over 98% of these patients had 20/25 or better vision on initial fitting; and subjective ratings of lens comfort were very good. Only 3.7% (27 of 733) discontinued wearing their lenses during the study period. Thirty-four patients (5.6%) experienced a problem while wearing their contact lenses.

  7. Adherence of Pseudomonas aeruginosa to contact lenses

    SciTech Connect

    Miller, M.J.

    1988-01-01

    The purpose of this research was to examined the interactions of P. aeruginosa with hydrogel contact lenses and other substrata, and characterize adherence to lenses under various physiological and physicochemical conditions. Isolates adhered to polystyrene, glass, and hydrogel lenses. With certain lens types, radiolabeled cells showed decreased adherence with increasing water content of the lenses, however, this correlation with not found for all lenses. Adherence to rigid gas permeable lenses was markedly greater than adherence to hydrogels. Best adherence occurred near pH 7 and at a sodium chloride concentration of 50 mM. Passive adhesion of heat-killed cells to hydrogels was lower than the adherence obtained of viable cells. Adherence to hydrogels was enhanced by mucin, lactoferrin, lysozyme, IgA, bovine serum albumin, and a mixture of these macromolecules. Adherence to coated and uncoated lenses was greater with a daily-wear hydrogel when compared with an extended-wear hydrogel of similar polymer composition. Greater adherence was attributed to a higher concentration of adsorbed macromolecules on the 45% water-content lens in comparison to the 55% water-content lens.

  8. Modern scleral contact lenses: A review.

    PubMed

    van der Worp, Eef; Bornman, Dina; Ferreira, Daniela Lopes; Faria-Ribeiro, Miguel; Garcia-Porta, Nery; González-Meijome, José M

    2014-08-01

    Scleral contact lenses (ScCL) have gained renewed interest during the last decade. Originally, they were primarily used for severely compromised eyes. Corneal ectasia and exposure conditions were the primary indications. However, the indication range of ScCL in contact lens practices seems to be expanding, and it now increasingly includes less severe and even non-compromised eyes, too. All lenses that partly or entirely rest on the sclera are included under the name ScCL in this paper; although the Scleral Lens Education Society recommends further classification. When a lens partly rests on the cornea (centrally or peripherally) and partly on the sclera, it is called a corneo-scleral lens. A lens that rests entirely on the sclera is classified as a scleral lens (up to 25 mm in diameter maximum). When there is full bearing on the sclera, further distinctions of the scleral lens group include mini-scleral and large-scleral lenses. This manuscript presents a review of the current applications of different ScCL (all types), their fitting methods, and their clinical outcomes including potential adverse events. Adverse events with these lenses are rare, but the clinician needs to be aware of them to avoid further damage in eyes that often are already compromised. The use of scleral lenses for non-pathological eyes is discussed in this paper.

  9. 'Colored' and Decorative Contact Lenses: A Prescription Is a Must

    MedlinePlus

    ... Home For Consumers Consumer Updates 'Colored' and Decorative Contact Lenses: A Prescription Is A Must Share Tweet ... care.” back to top Where NOT to Buy Contact Lenses FDA is aware that many places illegally ...

  10. Gas-permeable cellulose acetate butyrate (CAB) contact lenses.

    PubMed

    Hales, R H

    1977-09-01

    Gas-permeable cellulose acetate butyrate (CAB) contact lenses may often be worn succesfully by aphakic and other patients who are unable to wear hard contact lenses. The comfort characteristics of the CAB lenses are betweeen those of hard and soft contact lenses. They are much more permeable to O2 and CO2 than soft lenses and thus are less apt to cause edema. They are more flexible and more wettable than hard lenses. This study presents 50 patients who, having had to discontinue wearing hard contact lenses because of discomfort, diffuse central corneal edema, or visual problems, were fitted with CAB contact lenses. Thirty of the fifty were able to wear the CAB lenses successfully.

  11. Are silicone hydrogel contact lenses more comfortable than hydrogel contact lenses?

    PubMed

    Guillon, Michel

    2013-01-01

    The current literature review was intended to investigate whether the use of silicone hydrogel contact lenses has resulted in improved comfort compared with that of hydrogel contact lenses when both are used for daily wear. The conclusion reached is that silicone hydrogel contact lenses, which were initially developed to eliminate hypoxia during overnight wear, have not significantly improved comfort compared with the comfort achieved with hydrogel contact lenses when worn on a daily wear basis, even though a body of the published literature would suggest to the contrary. A careful review and consideration of the literature demonstrates that the relative comfort achieved with the two types of contact lenses is in fact highly dependent on the study methodology: Although refitting studies have concluded enhanced comfort with silicone hydrogels, the more robust study designs involving concurrent controls and masking were not able to show a difference, and some even concluded an inferior performance. Evidence-based review has however clearly demonstrated that comfort cannot be considered in isolation but is contact lens specific and depends on the material surface and bulk properties, lens design characteristics, and modality of use of the contact lens, and may also be significantly influenced by the replacement frequency and interaction with any lens care system that may be used.

  12. Comparative performance of disposable soft contact lenses.

    PubMed

    Young, G; Allsopp, G; Inglis, A; Watson, S

    1997-01-01

    A short-term clinical study was undertaken to compare and evaluate the fit and clinical behaviour of eight disposable hydrogel contact lenses. Thirty subjects were enrolled in a 1-day, randomised, double-masked study. The lenses compared were Vistakon Acuvue (8.80), Vistakon Surevue (8.80), Aspect Frequency-55, Bausch & Lomb Medalist (SeeQuence 2), Ciba Focus (8.90), Lunelle Rythmic, Pilkington Barnes Hind Precision-Wand Wesley Jessen Freshlook. Three of the eight designs, Acuvue (86.7%), Precision-UV (86.7%) and Frequency-55 (90%), achieved relatively high levels of fitting success. The Rythmic lenses achieved the lowest success rate (70%) showing significantly greater downward decentration than the other designs. Although all the lenses were designed to fit a wide variety of eyes, they exhibited widely varying fitting characteristics. Some were more successful than others. The study shows that it is necessary for practitioners to utilise a range of lens designs in order to fit satisfactorily the typical contact lens population.

  13. Bifocal liquid lens zoom objective for mobile phone applications

    NASA Astrophysics Data System (ADS)

    Wippermann, F. C.; Schreiber, P.; Bräuer, A.; Craen, P.

    2007-02-01

    Miniaturized camera systems are an integral part of today's mobile phones which recently possess auto focus functionality. Commercially available solutions without moving parts have been developed using the electrowetting technology. Here, the contact angle of a drop of a conductive or polar liquid placed on an insulating substrate can be influenced by an electric field. Besides the compensation of the axial image shift due to different object distances, mobile phones with zoom functionality are desired as a next evolutionary step. In classical mechanically compensated zoom lenses two independently driven actuators combined with precision guides are needed leading to a delicate, space consuming and expansive opto-mechanical setup. Liquid lens technology based on the electrowetting effect gives the opportunity to built adaptive lenses without moving parts thus simplifying the mechanical setup. However, with the recent commercially available liquid lens products a completely motionless and continuously adaptive zoom system with market relevant optical performance is not feasible. This is due to the limited change in optical power the liquid lenses can provide and the dispersion of the used materials. As an intermediate step towards a continuously adjustable and motionless zoom lens we propose a bifocal system sufficient for toggling between two effective focal lengths without any moving parts. The system has its mechanical counterpart in a bifocal zoom lens where only one lens group has to be moved. In a liquid lens bifocal zoom two groups of adaptable liquid lenses are required for adjusting the effective focal length and keeping the image location constant. In order to overcome the difficulties in achromatizing the lens we propose a sequential image acquisition algorithm. Here, the full color image is obtained from a sequence of monochrome images (red, green, blue) leading to a simplified optical setup.

  14. 'Contact' in Space Leads to New Lenses

    NASA Technical Reports Server (NTRS)

    2004-01-01

    While gravity has its advantages in keeping us balanced and grounded here on Earth, scientists often find that they are at a disadvantage when trying to conduct research under its powerful, pulling influence. In these instances, the scientists prefer performing their studies in the weightless atmosphere of microgravity, where gravity is greatly reduced and solids, liquids, and gases behave differently. In 1993, Paragon Vision Sciences, Inc., of Mesa, Arizona, participated in a research project with NASA's Langley Research Center to perfect a process for developing contact lenses. The project called for three experiments that would fly onboard the Space Shuttle over the course of three separate missions, from 1993 to 1996. By unleashing contact lens materials to the microgravity settings of space, scientists from NASA and Paragon hoped to better understand how polymers - large molecules that make up plastics - are formed.

  15. The Effect of Two-Zone Concentric Bifocal Spectacle Lenses on Refractive Error Development and Eye Growth in Young Chicks

    PubMed Central

    Wildsoet, Christine

    2011-01-01

    Purpose. To characterize the effects on refractive error development and eye growth in young chicks of two-zone concentric lens designs, which differentially affect the defocus experiences of central and peripheral retinal regions. Methods. Monocular defocusing lenses were worn for 5 days from 17 days of age. Four two-zone concentric lens designs (overall optical zone diameter, 10 mm) combining plano with either −5- or +5-D power were used. Lens designs were as follows: (1) +5 D center (+5C), (2) +5 D periphery (+5P), (3) −5 D center (−5C), and (4) −5 D peripheral (−5P), with plano in periphery for all C-designs and in the center for P-designs. Five central zone diameters (CZDs) were tested, ranging from 2.5 to 6.5 mm in 1-mm increments. Plano, +5- and −5-D single-vision (SV) lenses were used as the control. A minimum of six birds were included in each lens group. Results. For the two-zone lenses, the P designs (i.e., peripheral defocus) had greater effects than the C designs (i.e., central defocus) on both on-axis eye growth and refractions. All but the 6.5-mm CZD +5P lens induced larger changes than the +5SV lens. The +5C lenses with CZD less than 5.5 mm had little effect. The two-zone −5-D lenses had less effect than the −5SV lens, and only the 6.5-mm CZD lens of the −5C series had a significant effect. Conclusions. The results demonstrate that peripheral defocus can influence both peripheral and central refractive development. The inhibitory effect on axial eye growth of the +5P lenses opens the possibility that appropriately designed concentric lenses may control the progression of human myopia. PMID:20861487

  16. Interactions of benzalkonium chloride with soft and hard contact lenses

    SciTech Connect

    Chapman, J.M.; Cheeks, L.; Green, K. )

    1990-02-01

    We measured the uptake and washout of benzalkonium chloride, using radioactive tracer, by representative hard and soft contact lenses. Uptake by soft contact lenses after 7 days of continuous exposure is high (30 to 56 micrograms/mg of lens weight), with a low percentage of washout in 24 hours (between 0.2% and 1.5% of total uptake). High-water content lenses absorb greater quantities of benzalkonium than do low-water content lenses. Hard lenses take up a much smaller quantity of benzalkonium but release between 30% and 60% of total uptake during washout for 24 hours. Fluorosilicone-acrylate polymer lenses adsorb and release the most preservative, while polymethylmethacrylate lenses (Paragon Optical Inc, Mesa, Ariz) adsorb and release the least. The released benzalkonium from either soft or hard lenses is of a sufficient concentration to be at or above the upper limits of safety.

  17. Contact lenses in extreme cold environments: response of rabbit corneas.

    PubMed

    Socks, J F

    1982-04-01

    Contact lenses are worn by many individuals in military and civilian populations. Anecdotal reports have described contact lenses "sticking" and "freezing" to the eye during extreme cold conditions. However, some articles indicate the advantages of wearing contact lenses in cold environments. Military operations frequently taken place in cold regions; therefore, we need to known whether contact lenses can be worn safely in extreme cold. Rabbits were fitted with hard (polymethyl methacrylate) contact lenses and exposed to -28.9 degrees C temperatures with winds up to 78 mph (125 km/hr) for 3-hr periods. The wind-chill factor in these conditions exceeded -67.8 degrees C. No effects of the cold or contact lenses were seen in 85% of the eyes. A few of the eyes, both with contact lenses and without, showed mild superficial fluorescein staining of the cornea which cleared within a few ours after exposure. Histologic examination of the corneas revealed no abnormalities attributable to the cold. Inasmuch as this study showed that rabbits wearing contact lenses in extreme cold suffered no acute deleterious effects to the eyes, the research can be expanded to include human subjects.

  18. Extended drug delivery by contact lenses for glaucoma therapy.

    PubMed

    Peng, Cheng-Chun; Burke, Michael T; Carbia, Blanca E; Plummer, Caryn; Chauhan, Anuj

    2012-08-20

    We combine laboratory-based timolol release studies and in vivo pharmacodynamics studies in beagle dogs to evaluate the efficacy of glaucoma therapy through extended wear contact lenses. Commercial contact lenses cannot provide extended delivery of ophthalmic drugs and so the studies here focused on increasing the release duration of timolol from ACUVUE TruEye contact lenses by incorporating vitamin E diffusion barriers. The efficacy of timolol delivered via extended wear contact lenses was then compared to eye drops in beagle dogs that suffer from spontaneous glaucoma. The lenses were either replaced every 24h or continuously worn for 4 days, and the pharmacodynamics effect of changes in the intraocular pressure (IOP) of timolol from the ACUVUE TruEye contact lenses can be significantly increased by incorporation of vitamin E. The in vivo studies showed that IOP reduction from baseline by pure contact lens on daily basis was comparable with that by eye drops but with only 20% of drug dose, which suggested higher drug bioavailability for contact lenses. In addition, by inclusion of vitamin E into the lenses, the IOP was reduced significantly during the 4-day treatment with continuous wear of lens.

  19. Corneal epithelial permeability during extended wear of disposable contact lenses versus daily wear of soft contact lenses.

    PubMed Central

    Schurmans, L R; Boets, E P; van Best, J A

    1995-01-01

    AIMS--The corneal epithelial permeability during extended wear of disposable contact lenses was compared with that during daily wear of soft contact lenses. The study was performed to verify whether the extended wear of disposable contact lenses would result in a higher permeability value than the daily wear of soft contact lenses. A higher permeability makes the cornea more vulnerable for bacterial infections and thus could explain the higher incidence of bacterial keratitis found in extended wear of disposable contact lenses in comparison with the daily wear of soft contact lenses. METHOD--The corneal epithelial permeability was determined by fluorophotometry in 33 healthy volunteers after the wear of soft, daily wear contact lenses for at least 6 months. Thereafter the determination was repeated in each volunteer after extended wear of disposable contact lenses for 1 month. The permeability in 34 healthy non-contact lens wearing volunteers was determined as a control. The permeability value was calculated from the amount of fluorescein that passed into the cornea after application by means of an eyebath. RESULTS--The mean permeability values after daily and extended wear were 0.032 nm/s and 0.031 nm/s, respectively. The values were not significantly different (Wilcoxon paired test p > 0.5). The mean permeability for the non-contact lens wearing controls was 0.042 nm/s. CONCLUSION--The results do not sustain the explanation that a difference in permeability value is the main cause of the increased incidence of keratitis during extended wear of disposable contact lenses in comparison with daily wear. PMID:7742282

  20. Ultraviolet transmittance of the Vistakon disposable contact lenses.

    PubMed

    Harris, M G; Chin, R S; Lee, D S; Tam, M H; Dobkin, C E; Dobkins, C E

    2000-01-01

    With increasing scientific evidence demonstrating the harmful effects of ultraviolet (UV) radiation on different ocular tissues, contact lens manufacturers are incorporating UV blocking monomers into their contact lenses. This study evaluated the transmittance spectra of Vistakon's disposable soft contact lenses (1 Day Acuvue, Acuvue, Surevue, and Vistavue). All except Vistavue contain a UV blocking agent. Transmittance for each lens was recorded from 200 to 400 nm on a Shimadzu UV 160U Dual Beam Recording Spectrophotometer. The results indicate that lenses which incorporate the UV blocking monomer significantly reduced the transmission of W radiation while untreated lenses did not. Our findings indicate that 1 Day Acuvue, Surevue, and Acuvue meet the American National Standards Institution (ANSI) Standard Z80.20 for Class 2 UV blockers: a maximum of 30% transmittance of UVA wavelengths and 5% transmittance of UVB wavelengths. In contrast, the Vistavue lens demonstrated negligible UV blockage. Our technique, in which contact lenses were placed directly in front of a measuring beam, was accurate and simpler than previously reported methods and may be useful in future studies. We found that UV blocking soft contact lenses can be a viable alternative for spectacles in protecting internal ocular structures from UV radiation. However, the external structures of the eye remain at risk and would continue to benefit from the use of UV blocking sunglasses or spectacle lenses.

  1. The Danger of Using Tap Water with Contact Lenses

    EPA Pesticide Factsheets

    Acanthamoeba is a microbe that is very common in tap water. It has two forms: the trophozoite and the cyst. These trophozoites and cysts can stick to the surface of your contact lenses and then infect your eye.

  2. Sustained in vivo release from imprinted therapeutic contact lenses.

    PubMed

    Tieppo, A; White, C J; Paine, A C; Voyles, M L; McBride, M K; Byrne, M E

    2012-02-10

    In this paper, we demonstrate the successful in vivo extended release of a small molecular weight therapeutic, ketotifen fumarate (MW=425), from molecularly imprinted, therapeutic contact lenses. This is the first time that a steady, effective concentration of drug is maintained in the tear film from a contact lens for an extended period of time for the entire duration of lens wear. Poly(HEMA-co-AA-co-AM-co-NVP-co-PEG200DMA) soft contact lenses were prepared (100±5 μm thickness, diameter 11.8 mm, power zero), and a constant tear film concentration of 170±30 μg/mL was measured for up to 26 hrs in a New Zealand white rabbit model. The results showed a dramatic increase in ketotifen mean residence time (MRT) and bioavailability compared to topical drop therapy and drug soaked lenses. The MRT for imprinted lenses was 12.47±3.99 hrs, ~4 and 50 fold greater than non-imprinted lenses and 0.035% eye drops (Zaditor®), respectively. Furthermore, AUC(0-26 hrs) was 9 and 94 fold greater for imprinted lenses than non-imprinted lenses and eye drops, respectively. The results indicate that molecular imprinting provides an exciting rational engineering strategy for sustained release. It is clear that imprinted lenses are very promising combination devices and are much more effective and efficient delivery devices than eye drops.

  3. Flexibility of hard gas permeable contact lenses.

    PubMed

    Stevenson, R W

    1988-11-01

    Gas permeable (GP) lenses can flex on some eyes producing unpredictable clinical results. A method of measuring the flexibility of hard GP materials has been developed and shown to be repeatable. Materials in the form of flats rather than lenses were used. Differences between materials were found and in general a linear relation was shown to exist between maximum flexing and quoted oxygen permeability (r = 0.78, p less than 0.05). It is recommended that flexibility be measured and reported in the data presented with all new GP polymers. The term "hard" rather than "rigid" in describing GP lenses is suggested.

  4. The Use of Contact Lenses in Industrial Environments: An Assessment of Current Research and Policy.

    ERIC Educational Resources Information Center

    Connors, Terry

    2001-01-01

    Attempts to dispel rumors concerning contact lenses and tries to supply prudent-use practices for allowing contact lenses in industry and laboratories. Discusses federal regulations that impact the use of contact lenses in industry, policy statements from medical organizations on use of contact lenses in industrial environments, and the…

  5. Inhibition of Lens Photodamage by UV-Absorbing Contact Lenses

    PubMed Central

    Malone, James P.; Townsend, R. Reid

    2011-01-01

    Purpose. To determine whether class 1 UV-blocking contact lenses protect against UVB radiation–induced damage in a human lens epithelial cell line (HLE B-3) and postmortem human lenses using a proteomics approach. Methods. HLE B-3 cells were exposed to 6.4 mW/cm2 UVB radiation at 302 nm for 2 minutes (768 mJ/cm2) with or without covering by senofilcon A class 1 UV-blocking contact lenses or lotrafilcon A non–UV-blocking (lotrafilcon A has some UV-blocking ability, albeit minimal) contact lenses. Control cells were not exposed to UVB radiation. Four hours after treatment, cells were analyzed by two-dimensional difference gel electrophoresis and tandem mass spectrometry, and changes in protein abundance were quantified. F-actin and microtubule cytoskeletons were examined by fluorescence staining. In addition, human donor lenses were exposed to UVB radiation at 302 nm for 4 minutes (1536 mJ/cm2). Cortical and epithelial cell proteins were scraped from lens surfaces and subjected to the same protein analyses. Results. Senofilcon A lenses were beneficial for protecting HLE B-3 cells against UVB radiation–induced changes in caldesmon 1 isoform, lamin A/C transcript variant 1, DEAD (Asp-Glu-Ala-Asp) box polypeptide, β-actin, glyceraldehyde 3-phosphate dehydrogenase (G3PDH), annexin A2, triose phosphate isomerase, and ubiquitin B precursor. These contact lenses also prevented actin and microtubule cytoskeleton changes typically induced by UVB radiation. Conversely, non–UV-blocking contact lenses were not protective. UVB-irradiated human lenses showed marked reductions in αA-crystallin, αB-crystallin, aldehyde dehydrogenase 1, βS-crystallin, βB2-crystallin, and G3PDH, and UV-absorbing contact lenses significantly prevented these alterations. Conclusions. Senofilcon A class 1 UV-blocking contact lenses largely prevented UVB-induced changes in protein abundance in lens epithelial cells and in human lenses. PMID:21873653

  6. Development of ciprofloxacin-loaded contact lenses using fluorous chemistry.

    PubMed

    Qin, Guoting; Zhu, Zhiling; Li, Siheng; McDermott, Alison M; Cai, Chengzhi

    2017-04-01

    In this work, we developed a simple method to load drugs into commercially available contact lenses utilizing fluorous chemistry. We demonstrated this method using model compounds including fluorous-tagged fluorescein and antibiotic ciprofloxacin. We showed that fluorous interactions facilitated the loading of model molecules into fluorocarbon-containing contact lenses, and that the release profiles exhibited sustained release. Contact lenses loaded with fluorous-tagged ciprofloxacin exhibited antimicrobial activity against Pseudomonas aeruginosa in vitro, while no cytotoxicity towards human corneal epithelial cells was observed. To mimic the tear turnover, we designed a porcine eye infection model under flow conditions. Significantly, the modified lenses also exhibited antimicrobial efficacy against Pseudomonas aeruginosa in the ex vivo infection model. Overall, utilizing fluorous chemistry, we can construct a drug delivery system that exhibits high drug loading capacity, sustained drug release, and robust biological activity.

  7. Giant papillary conjunctivitis associated with rigid gas permeable contact lenses.

    PubMed

    Douglas, J P; Lowder, C Y; Lazorik, R; Meisler, D M

    1988-01-01

    Giant papillary conjunctivitis (GPC) is an external ocular inflammatory disorder associated with contact lens wear. GPC seems to occur less frequently with hard than with soft contact lens wear. The management of soft contact lens related GPC has included refitting with hard lenses, specifically the newer rigid gas permeable (RGP) lenses. We retrospectively studied 14 RGP lens wearers in whom GPC developed. Three patients had had GPC associated with soft contact lens wear and had been fitted with RGP lenses in an effort to restore contact lens tolerance. The interval of time between the initiation of RGP lens wear and the onset of GPC was inversely related to the lens oxygen transmissibility (DK value). Ophthalmologists should be aware of the association between GPC and rigid gas permeable lens wear.

  8. A review on therapeutic contact lenses for ocular drug delivery.

    PubMed

    Maulvi, Furqan A; Soni, Tejal G; Shah, Dinesh O

    2016-10-01

    Contact lenses for ophthalmic drug delivery have become very popular, due to their unique advantages like extended wear and more than 50% bioavailability. To achieve controlled and sustained drug delivery from contact lenses, researchers are working on various systems like polymeric nanoparticles, microemulsion, micelle, liposomes, use of vitamin E, etc. Numerous scientists are working on different areas of therapeutic contact lenses to treat ocular diseases by implementing techniques like soaking method, molecular imprinting, entrapment of drug-laden colloidal nanoparticles, drug plate/film, ion ligand polymeric systems, supercritical fluid technology, etc. Though sustained drug delivery was achieved using contact lens, the critical properties such as water content, tensile strength (mechanical properties), ion permeability, transparency and oxygen permeability were altered, which limit the commercialization of therapeutic contact lenses. Also issues like drug stability during processing/fabrication (drug integrity test), zero order release kinetics (prevent burst release), drug release during monomer extraction step after fabrication (to remove un-reacted monomers), protein adherence, drug release during storage in packaging solution, shelf life study, cost-benefit analysis, etc. are still to be addressed. This review provides an expert opinion on different methodology to develop therapeutic contact lenses with special remark of their advantages and limitations.

  9. Adverse events in allergy sufferers wearing contact lenses

    PubMed Central

    Urgacz, Agnieszka; Mrukwa, Ewa

    2015-01-01

    Allergy is the fifth leading chronic condition in industrialized countries among all ages, and the third most common chronic disease among children under 18 years old. Many of allergic patients also have problems with vision and want to improve their quality of life by wearing contact lenses. They are most frequently young and active individuals, for whom contact lenses provide greater convenience and more satisfying vision correction than spectacles. However, application of high quality and immunologically neutral products do not protect from allergic side reactions. Nowadays, eye-related allergy and contact lens wear concern larger and larger populations worldwide. The purpose of this review is to summarize the studies on ocular complications associated with wearing contact lenses. The article presents indications for allergic patients especially on the care system and wear schedule. PMID:26161062

  10. Development of contact lenses and their worldwide use.

    PubMed

    Key, James E

    2007-11-01

    The concept of applying a lens to the cornea as a refractive appliance was first proposed in the early 19th century. By 1888, glass scleral lenses for the correction of optical defects and irregularities were manufactured and used. New materials, especially soft hydrogel lenses and rigid gas-permeable lenses, became available in the 20th century and allowed comfortable contact lenses to be made in any design needed. By the 21st century, the increasing use of silicone hydrogel lenses to address the oxygen need of the cornea has led to increased worldwide use. Of the 125 million global contact lens wearers, most are female and relatively young. Soft lenses are by far the dominant modality used, with silicone hydrogel lenses taking an increasing share of new fittings, particularly for overnight wear. Microbial keratitis, although relatively uncommon, remains the most serious potential complication for these lens wearers. Ongoing basic research, more powerful antimicrobial agents, and the development of safer lens materials are helping to alleviate this problem.

  11. Ophthalmic glucose monitoring using disposable contact lenses--a review.

    PubMed

    Badugu, Ramachandram; Lakowicz, Joseph R; Geddes, Chris D

    2004-09-01

    We have developed a range of disposable and colorless tear glucose sensing contact lenses, using off-the-shelf lenses embedded with new water soluble, highly fluorescent and glucose sensitive boronic acid containing fluorophores. The new lenses are readily able to track tear glucose levels and therefore blood glucose levels, which are ideally suited for potential use by diabetics. The fluorescence responses from the lenses can be monitored using simple excitation and emission detection devices. The novelty of our approach is two fold. Firstly, the notion of sensing extremely low glucose concentrations in tears, which track blood levels, by our contact lens approach, and secondly, the unique compatibility of our new glucose signaling probes with the internal mildly acidic contact lens environment. The new lenses are therefore ideal for the non-invasive and continuous monitoring of tear glucose, with about 15-min response time, and a measured shelf life in excess of 3 months. In this review article, we show that fluorescence based signaling using plastic disposable lenses, which have already been industrially optimized with regard to vision correction and oxygen/analyte permeability etc, may a notable alternative to invasive and random finger pricking, the most widely used glucose monitoring technology by diabetics.

  12. Oxygen permeability of hydrogel contact lenses with organosilicon moieties.

    PubMed

    Compañ, V; Andrio, A; López-Alemany, A; Riande, E; Refojo, M F

    2002-07-01

    Oxygen transport through two extended wear (day and night) hydrogel contact lenses that contain organosilicon moieties (balafilcon A and lotrafilcon A) was studied in the hydrate (hydrogel) and dry (xerogel) states. The water uptake increased the oxygen permeability [(Dk)app] and transmissibility [Dk/L(av)] coefficients of the dry materials by about 70%. The (Dk)app for the hydrated lenses was determined following the so-called stack procedure. The values obtained were 107 +/- 4 barrer for balafilcon A and 141 +/- 5 barrer for lotrafilcon A, about 5-10 times larger than those previously reported for conventional (without organosilicon moieties) extended wear hydrogels contact lenses. The Dk/L(av) for -3.00 diopter lenses (harmonic average thickness, L(av) = 75 +/- 2 microm for lotrafilcon, and 85 +/- 2 microm for balafilcon) was 123 +/- 6 barrer/cm for balafilcon A and 183 +/- 8 barrer/cm for lotralicon A. The minimum oxygen transmissibility 87 barrer/cm stipulated by Holden and Mertz to avoid corneal edema with extended wear contact can be easily achieved with lotrafilcon and balafilcon lenses of diverse dioptric powers if the central and peripheral thickness of the lenses are kept below the critical level of oxygen transmissibility.

  13. Research and analysis on new test lenses for calibration of focimeters used for measuring contact lenses

    NASA Astrophysics Data System (ADS)

    Zhang, Jiyan; Wang, Liru; Ma, Zhenya

    2006-11-01

    A focimeter is one of the basic ophthalmic instruments used in every optometric practice, and verification of the accuracy and calibration of the instrument are of the utmost importance. For many years the International Standardization for Organization requires that calibrations for all kinds of focimeters shall be accomplished by using test lenses described in ISO 9342:1996. These test lenses must be of high quality and of nominal back vertex power that is known with high accuracy. With the development of science and technology, ISO 9342 was revised in 2005. A new part ISO 9342-2 had been drafted for test lenses used to calibrate focimeters with contact lens measurement, and the original ISO 9342 was turned into the current ISO 9342-1, which could only be used to calibrate fociemters with spectacle lens measurement. As one of the standard drafters, the background for the newly published ISO 9342-2 is introduced in this study, and comparison between test lenses of ISO 9342-1 and ISO 9342-2 is made. Further, the influence of tolerance and uncertainty in design and production of standard test lenses of ISO 9342-2 is analyzed. The paraxial approximation is used to relate the lens parameters with back vertex power and to calculate the uncertainty budget. Moreover, one set of test lenses conforming to ISO 9342-2 is manufactured and experiments are done with it. Results show that test lenses described in ISO 9342-2 can correct the measurement errors of focimeters used for measuring contact lenses well, especially for spherical aberration, and the correction is more effective for spherical contact lenses with high back vertex power.

  14. Corneal ulcers associated with disposable hydrogel contact lenses.

    PubMed

    Dunn, J P; Mondino, B J; Weissman, B A; Donzis, P B; Kikkawa, D O

    1989-08-15

    Four patients developed corneal ulcers associated with the use of disposable extended-wear hydrogel contact lenses. Bacteria were recovered from corneal ulcers in three of the patients. Three patients discarded their contact lenses after ten or more days of extended wear; the corneal ulcers in these patients developed toward the end of the wearing cycle. The fourth patient removed her contact lenses every two days for cleaning and disinfection and discarded them for a new pair on a weekly basis. Improper lens hygiene was noted in only one patient. All corneal ulcers responded to antibiotic treatment. In three patients visual acuity returned to normal, but scarring of one patient's cornea resulted in a visual acuity of 20/60.

  15. Diffusion of Antimicrobials Across Silicone Hydrogel Contact Lenses

    PubMed Central

    Zambelli, Alison M.; Brothers, Kimberly M.; Hunt, Kristin M.; Romanowski, Eric G.; Nau, Amy C.; Dhaliwal, Deepinder K.; Shanks, Robert M. Q.

    2014-01-01

    Objectives To measure the diffusion of topical preparations of moxifloxacin, amphotericin B (AmB), and polyhexamethylene biguanide (PHMB) through silicone hydrogel (SH) contact lenses in vitro. Methods Using an in vitro model, the diffusion of three antimicrobials through SH contact lenses was measured. Diffused compounds were measured using a spectrophotometer at set time points over a period of four hours. The amount of each diffused antimicrobial was determined by comparing the experimental value to a standard curve. A biological assay was performed to validate the contact lens diffusion assay by testing antimicrobial activity of diffused material against lawns of susceptible bacteria (Staphylococcus epidermidis) and yeast (Saccharomyces cerevisiae). Experiments were repeated at least two times with a total of at least 4 independent replicates. Results Our data show detectable moxifloxacin and PHMB diffusion through SH contact lenses at 30 minutes, while amphotericin B diffusion remained below the limit of detection within the 4 hour experimental period. In the biological assay, diffused moxifloxacin demonstrated microbial killing starting at 20 minutes on bacterial lawns, whereas PHMB and amphotericin B failed to demonstrate killing on microbial lawns over the course of the 60 minute experiment. Conclusions In vitro diffusion assays demonstrate limited penetration of certain anti-infective agents through silicone hydrogel contact lenses. Further studies regarding the clinical benefit of using these agents along with bandage contact lens use for corneal pathology are warranted. PMID:25806673

  16. Cultured human ocular surface epithelium on therapeutic contact lenses

    PubMed Central

    Girolamo, Nick Di; Chui, Jeanie; Wakefield, Denis; Coroneo, Minas T

    2007-01-01

    Background This study was initiated after observation of some intriguing epithelial growth properties of contact lenses used as a bandage for patients after pterygium surgery. Aim To determine the efficacy of culturing human ocular surface epithelial cells on therapeutic contact lenses in autologous serum with a view of using this system to transfer epithelial cells to patients with persistent corneal or limbal defects. Methods Excess graft tissue resected from patients undergoing pterygium surgery (n = 3) consisting of limbal epithelium was placed on siloxane–hydrogel contact lenses (lotrafilcon A and balafilcon A). Limbal explants were cultured in media with 10% autologous serum. Morphology, proliferative capacity and cytokeratin profile were determined by phase contrast, light and electron microscopy, and immunohistochemical analysis. Results Lotrafilcon A contact lenses sustained proliferation and migration from limbal tissue. Cells became confluent after 10–14 days and consisted of 2–3 layers with a corneal phenotype (CK3+/CK12+/CK19−) and a propensity to proliferate (p63+). Electron microscopy showed microvilli on the apical surface with adhesive projections, indicating that these cells were stable and likely to survive for a long term. Growth was not observed from limbal explants cultured on balafilcon A contact lenses. Conclusion A method for culturing human ocular surface epithelium on contact lenses that may facilitate expansion and transfer of autologous limbal epithelial cells while avoiding the risks associated with transplanting allogeneic tissue has been developed. This technique may be potentially useful for the treatment of patients with limbal stem cell deficiency. PMID:16987897

  17. Bifocal dual reflector antenna

    NASA Technical Reports Server (NTRS)

    Rao, B. L. J.

    1973-01-01

    A bifocal dual reflector antenna is similar to and has better scan capability than classical cassegrain reflector antenna. The method used in determining the reflector surfaces is a modification of a design method for the dielectric bifocal lens. The three dimensional dual reflector is obtained by first designing an exact (in geometrical optics sense) two-point corrected two dimensional reflector and then rotating it around its axis of symmetry. A point by point technique is used in computing the reflector surfaces. Computed radiation characteristics of the dual reflector are compared with those of a cassegrain reflector. The results confirm that the bifocal antenna has superior performance.

  18. Operational Use Of Contact Lenses By Military Aircrew (L’Utilisation Operationnelle des Lentilles de Contact)

    DTIC Science & Technology

    1992-10-01

    whether soft contact lenses could be worn equipment is increasingly incompatible with spectacles and underneath a protective mask. Their concern was the...results completed a test of its chemical protection masks and have been shown°󈧣𔄃 with rigid lenses . respirator with SCLs, RGPs, spectacles , and no...electro-optical controlling and replacing the lenses are not medical issues, visual displays and protective masks, it has, in some cases, they were

  19. Dynamic wettability of pHEMA-based hydrogel contact lenses.

    PubMed

    Maldonado-Codina, Carole; Efron, Nathan

    2006-07-01

    Standard methods of contact angle analysis include sessile drop, captive bubble and Wilhelmy plate techniques; however, these methodologies are not particularly well suited for assessing the wettability of the surfaces of formed hydrogel contact lenses. This paper describes two methodologies that are adaptations of previously described techniques. The maximum adherent force method is an adaptation of the dynamic Wilhelmy plate technique that allows the assessment of whole, finished contact lenses. The dynamic photographic method allows the simultaneous assessment of the front and back surfaces of strip samples for the assessment of advancing and receding contact angles. Lenses investigated were made from polyhydroxyethyl methacrylate, hydroxyethyl methacrylate/methacrylic acid and hydroxyethyl methacrylate/glycerol methacrylate. The lenses were manufactured by lathing, spin-casting or cast-moulding techniques. Overall, both techniques demonstrated few differences between the wettability of different lens materials and no differences between materials of the 'same' lens type but manufactured by different methods. These findings are consistent with the results of clinical studies, which have shown little difference between contact lens surface wettability in vivo, which may be due to the apparent natural surface wettability-enhancing properties of the pre-lens tear film.

  20. Novel Approaches in Formulation and Drug Delivery using Contact Lenses

    PubMed Central

    Singh, Kishan; Nair, Anroop B; Kumar, Ashok; Kumria, Rachna

    2011-01-01

    The success of ocular delivery relies on the potential to enhance the drug bioavailability by controlled and extended release of drug on the eye surface. Several new approaches have been attempted to augment the competence and diminish the intrinsic side effects of existing ocular drug delivery systems. In this contest, progress has been made to develop drug-eluting contact lens using different techniques, which have the potential to control and sustain the delivery of drug. Further, the availability of novel polymers have facilitated and promoted the utility of contact lenses in ocular drug delivery. Several research groups have already explored the feasibility and potential of contact lens using conventional drugs for the treatment of periocular and intraocular diseases. Contact lenses formulated using modern technology exhibits high loading, controlled drug release, apposite thickness, water content, superior mechanical and optical properties as compared to commercial lenses. In general, this review discus various factors and approaches designed and explored for the successful delivery of ophthalmic drugs using contact lenses as drug delivery device PMID:24826007

  1. Bacterial adherence to extended wear soft contact lenses

    SciTech Connect

    Aswad, M.I.; John, T.; Barza, M.; Kenyon, K.; Baum, J. )

    1990-03-01

    The authors studied the adherence of Pseudomonas aeruginosa and Staphylococcus aureus to extended wear soft contact lenses (EWSCLs) with and without focal deposits using both a radiolabeling technique and electron microscopy. P. aeruginosa showed significant adherence to contact lenses in vitro. In contrast, S. aureus failed to show significant adherence to contact lenses in vitro (i.e., the radioactive uptake was not significantly above background). The extent of adherence of Pseudomonas was proportional to the number of focal deposits on the lenses. Results of electron microscopic examination showed the bacteria to be adherent primarily to large focal deposits (greater than or equal to 150 microns). There was no pseudomonal adherence to the small focal deposits (less than or equal to 50 microns) and little adherence to the areas in between the focal deposits. The authors hypothesize that worn lenses, especially those with large focal deposits, serve as a vehicle for the transport of P. aeruginosa to the cornea. This hypothesis could be a partial explanation for the high incidence of keratitis caused by P. aeruginosa in EWSCL patients.

  2. 16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule)....

  3. 16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule)....

  4. 16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule)....

  5. 16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule)....

  6. 16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule)....

  7. Comparison of visual outcomes and subjective visual quality after bilateral implantation of a diffractive trifocal intraocular lens and blended implantation of apodized diffractive bifocal intraocular lenses

    PubMed Central

    Gundersen, Kjell Gunnar; Potvin, Rick

    2016-01-01

    Purpose To compare the visual acuity (VA) and quality of vision between bilateral implantation of a trifocal intraocular lens (IOL) and blended bifocal IOLs with an intermediate add in the dominant eye and a near add in the nondominant eye. Patients and methods Patients with either trifocal or blended bifocal IOLs implanted were recruited after surgery. Subjects returned for a single diagnostic visit between 3 and 24 months after surgery. VA was tested at various distances, including low-contrast acuity and acuity at their preferred reading distance. A binocular defocus curve was obtained, and subjective visual function and quality of vision were evaluated. Results Twenty-five trifocal subjects and 30 blended bifocal subjects were enrolled. There were no significant differences in low-contrast acuity, preferred reading distance, or acuity at that reading distance. Binocular vision at 4 m, 60 cm, and 40 cm was not statistically significantly different. The trifocal provided statistically significantly better visual acuity (P<0.05) at vergences from −0.5 to −1.5 D (from 2 m to 67 cm viewing distance, P<0.05). There was no statistically significant difference in the near vision subscale scores of the 39-question National Eye Institute Visual Function Questionnaire or the overall scores of the Quality of Vision questionnaire, though significantly more trifocal subjects reported that the observed visual disturbances were “bothersome” (P<0.05). Conclusion Both lens modalities provided subjects with excellent binocular near and distance vision, with similar low rates of visual disturbances and good reported functional vision. The trifocal IOL provided significantly better intermediate VA in the viewing distance range of 2 m to 67 cm, corresponding to viewing things such as a car dashboard or grocery shelf. VA was similar between groups at viewing distances from 60 to 40 cm, corresponding to computer or reading distance. PMID:27274184

  8. Hydrogen peroxide mechanosynthesis in siloxane-hydrogel contact lenses.

    PubMed

    Tavazzi, Silvia; Ferraro, Lorenzo; Cozza, Federica; Pastori, Valentina; Lecchi, Marzia; Farris, Stefano; Borghesi, Alessandro

    2014-11-26

    Drug-loaded contact lenses are emerging as the preferred treatment method for several ocular diseases, and efforts are being directed to promote extended and controlled delivery. One strategy is based on delivery induced by environmental triggers. One of these triggers can be hydrogen peroxide, since many platforms based on drug-loaded nanoparticles were demonstrated to be hydrogen-peroxide responsive. This is particularly interesting when hydrogen peroxide is the result of a specific pathophysiological condition. Otherwise, an alternative route to induce drug delivery is here proposed, namely the mechano-synthesis. The present work represents the proof-of-concept of the mechanosynthesis of hydrogen peroxide in siloxane-hydrogel contact lenses as a consequence of the cleavage of siloxane bonds at the interface between the polymer and water in aqueous phase. Their spongy morphology makes contact lenses promising systems for mechanical-to-chemical energy conversion, since the amount of hydrogen peroxide is expected to scale with the interfacial area between the polymer and water. The eyelid pressure during wear is sufficient to induce the hydrogen peroxide synthesis with concentrations which are biocompatible and suitable to trigger the drug release through hydrogen-peroxide-responsive platforms. For possible delivery on demand, the integration of piezoelectric polymers in the siloxane-hydrogel contact lenses could be designed, whose mechanical deformation could be induced by an applied wireless-controlled voltage.

  9. Multifocal rigid gas permeable contact lenses with reduced halo

    NASA Astrophysics Data System (ADS)

    ben Yaish, Shai; Zlotnik, Alex; Limon, Ofer; Lahav Yacouel, Karen; Doron, Ravid; Zalevsky, Zeev

    2014-05-01

    In this communication we present the first dispensing medical trial in which we successfully report on testing of novel extended depth of focus rigid gas permeable (RGP) contact lenses having reduced halo and distinct focal peaks for near and far distance vision.

  10. [Lens prescription for rigid contact lenses in keratoconus].

    PubMed

    Manea, Georgiana

    2012-01-01

    Rigid Gas-Permeable contact lenses is a less risky option for improving the quality of vision in corneal ectasias such as keratoconus. They reshape the corneal surface (flattens the cornea) so that in most cases, with a proper lens, the patient can reach a visual acuity of 20/20.

  11. Soft multifocal simultaneous image contact lenses: a review.

    PubMed

    Pérez-Prados, Roque; Piñero, David P; Pérez-Cambrodí, Rafael J; Madrid-Costa, David

    2017-03-01

    Soft multifocal simultaneous image contact lenses have boomed in recent years due to the growing number of presbyopic patients demanding visual solutions, allowing them to maintain their current standard of living. The concept of 'simultaneous image' is based on blur interpretation and/or blur tolerance of superimposed multiple images on the retina formed by various powers of a contact lens. This is the basis for a specific type of multifocal contact lens developed for the compensation of presbyopia. Manufacturers have released a great variety of soft simultaneous image lens designs to meet different patient needs but their fitting is still unsatisfactory in some cases. Some presbyopes discontinue wearing contact lenses due to some limitations in visual quality and comfort that can be overcome with an appropriate contact lens selection based on a comprehensive pre-fitting evaluation. This paper aims to review the different types of soft multifocal contact lenses that are currently available for presbyopic correction and to define the steps and factors crucial for their fitting, such as pupil, aberrations, accommodation and centring. A discussion about useful tools to achieve a customised fitting leading to a successful outcome, such as the defocus curve, power profile and questionnaires, is performed.

  12. Teaching Young Children to Use Contact Lenses.

    ERIC Educational Resources Information Center

    Mathews, Judith R.; And Others

    1992-01-01

    Four young children were taught contact lens wear using a shaping procedure, which involved praise and tangibles for compliance and time-outs or restraint for noncompliance. At followup, levels of compliance were high for three children, while a subject with Down's syndrome showed low compliance with need for physical restraint throughout.…

  13. Extended elution of phospholipid from silicone hydrogel contact lenses.

    PubMed

    Pitt, William G; Zhao, Yibei; Jack, Daniel R; Perez, Krystian X; Jones, Peter W; Marelli, Ryan; Nelson, Jared L; Pruitt, John D

    2015-01-01

    Characterization of phospholipid release from an experimental reusable wear silicone hydrogel contact lens was performed to assess the possible use of these lenses for phospholipid delivery to increase eye comfort to patients who prefer reusable wear lenses. Contact lenses were loaded with 200 μg of radio-labeled 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) from a solution of n-propanol. To simulate 30 days of diurnal use with overnight cleaning, these lenses were eluted for 16 h at 35 °C into artificial tear fluid (ATF), and then eluted at room temperature (~22 °C) for 8 h in one of three commercial contact lens cleaning systems. This was repeated for 30 days. The elution of DMPC into ATF was greater on the first day, followed by a fairly constant amount of elution each day thereafter. The type of cleaning system had a statistically significant effect on the elution rate during daily exposure to ATF. The rate of elution into cleaning solutions did not show any enhanced elution on the first day; there was a fairly constant elution rate. Again, the type of cleaning system significantly influenced the elution rate into the nightly cleaner.

  14. In-office microwave disinfection of soft contact lenses

    SciTech Connect

    Harris, M.G.; Rechberger, J.; Grant, T.; Holden, B.A. )

    1990-02-01

    We evaluated the effectiveness of an in-office microwave disinfection procedure which allowed for the disinfection of up to 40 soft contact lenses at one time. Ciba AOSept cases filled with sterile unpreserved saline were contaminated with one of six FDA test challenge microorganisms at a concentration of approximately 10(3) colony forming units per milliliter (CFU/ml). Twenty cases were placed on the rotating plate of a standard 2450 MHz 650 W microwave oven in a 10-cm diameter circle. The cases were exposed to high intensity microwave irradiation for periods of 0 to 15 min. None of the 6 microorganisms evaluated survived 2 min or longer of microwave exposure. Our findings indicated that microwave irradiation can be a convenient, rapid, and effective method of disinfecting a number of soft contact lenses at one time and thus adaptable as an in-office soft contact lens disinfection procedure.

  15. Controlled Release of Multiple Therapeutics from Silicone Hydrogel Contact Lenses

    PubMed Central

    White, Charles J.; DiPasquale, Stephen A.; Byrne, Mark E.

    2016-01-01

    Purpose The majority of contact lens wearers experience a significant level of ocular discomfort associated with lens wear, often within hours of wear, related to dry lenses, inflammation, protein adhesion to the lens surface, etc. Application of controlled drug release techniques has focused on the incorporation and/or release of a single comfort molecule from a lens including high molecular weight comfort agents or pharmaceutical agents. Previous studies have sought to mitigate the occurrence of only single propagators of discomfort. Clinical studies with eye drop solutions have shown that a mixture of diverse comfort agents selected to address multiple propagators of discomfort provide the greatest and longest lasting sensations of comfort for the patient. In this paper, multiple propagators of discomfort are addressed through the simultaneous release of four molecules from a novel contact lens to ensure high level of lens wear comfort. Methods Silicone hydrogel contact lenses were engineered via molecular imprinting strategies to simultaneously release up to four template molecules including hydropropyl methylcellulose (HPMC), trehalose, ibuprofen, and prednisolone. Results By adjusting the ratio of functional monomer to comfort molecule, a high level of control was demonstrated over the release rate. HPMC, trehalose, ibuprofen, and prednisolone were released at therapeutically relevant concentrations with varying rates from a single lens. Conclusions The results indicate use as daily disposable lenses for single day release or extended-wear lenses with multiple day release. Imprinted lenses are expected to lead to higher efficacy for patients compared to topical eye drops by improving compliance and mitigating concentration peaks and valleys associated with multiple drops. PMID:26945177

  16. Ultraviolet radiation for the sterilization of contact lenses

    SciTech Connect

    Gritz, D.C.; Lee, T.Y.; McDonnell, P.J.; Shih, K.; Baron, N. )

    1990-10-01

    Two sources of ultraviolet (UV) radiation with peak wavelengths in the UV-C or UV-B ranges were compared for their ability to sterilize contact lenses infected with Pseudomonas aeruginosa, Streptococcus pneumoniae, Acanthamoeba castellani, Candida albicans, and Aspergillus niger. Also examined was the effect of prolonged UV light exposure on soft and rigid gas permeable (RGP) contact lenses. The UV-C lamp (253.7 nm, 250 mW/cm2 at 1 cm) was germicidal for all organisms within 20 minutes but caused destruction of the soft lens polymers within 6 hours of cumulative exposure. UV-C caused damage to RGP lenses in less than 100 hours. The UV-B lamp (290-310 nm, 500 mW/cm2 at 1 cm) was germicidal for all organisms tested (except Aspergillus) with a 180-minute exposure and caused less severe changes in the soft lens polymers than did the UV-C lamp, although cumulative exposure of 300 hours did substantially weaken the soft lens material. RGP materials were minimally affected by exposure to 300 hours of UV-B. Ultraviolet light is an effective germicidal agent but is injurious to soft lens polymers; its possible utility in the sterilization of RGP lenses and lens cases deserves further study.

  17. Mechanically triggered solute uptake in soft contact lenses.

    PubMed

    Tavazzi, Silvia; Ferraro, Lorenzo; Fagnola, Matteo; Cozza, Federica; Farris, Stefano; Bonetti, Simone; Simonutti, Roberto; Borghesi, Alessandro

    2015-06-01

    Molecular arrangement plays a role in the diffusion of water and solutes across soft contact lenses. In particular, the uptake of solutes in hydrated contact lenses can occur as long as free water is available for diffusion. In this work, we investigated the effect of mechanical vibrations of low frequency (200 Hz) on the solute uptake. Hyaluronan, a polysaccharide of ophthalmic use, was taken as example of solute of interest. For a specific water-hydrated hydrogel material, differential scanning calorimetry experiments showed that a large fraction of the hydration water accounted for loosely-bound water, both before and after one week of daily-wear of the lenses. The size (of the order of magnitude of few hundreds of nanometers) of hyaluronan in aqueous solution was found to be less than the size of the pores of the lens observed by scanning electron microscopy. However, solute uptake in already-hydrated lenses was negligible by simple immersion, while a significant increase occurred under mechanical vibrations of 200 Hz, thus providing experimental evidence of mechanically triggered enhanced solute uptake, which is attributed to the release of interfacial loosely-bound water. Also other materials were taken into consideration. However, the effectiveness of mechanical vibrations for hyaluronan uptake is restricted to lenses containing interfacial loosely-bound water. Indeed, loosely-bound water is expected to be bound to the polymer with bonding energies of the order of magnitude of 10-100 J/g, which are compatible with the energy input supplied by the vibrations.

  18. [Corneal metabolism with contact lenses in competitive sports].

    PubMed

    Schnell, D; Khaireddin, R

    2013-06-01

    The corneal metabolism during the use of contact lenses plays an important role for permanent corneal health, especially in competitive sports. Thus, it is important to understand the steps of corneal metabolism in general and during highly competitive sports activity in particular. The aim of this review is to summarize the current knowledge on physiological and biochemical effects of contact lens wear. Of the energy requirements of the cornea 75 % is supplied by aerobic processes; therefore, the eye needs the highest possible amount of oxygen and sufficient glucose which can be obtained from external air and to a lesser degree from within the anterior chamber. If the oxygen supply is too low this results in hypoxic edema. Fitting athletes with contact lenses must still be viewed with caution as the visual needs of athletes are usually much more demanding than those of the general public. An indiscriminate choice of lens design can adversely affect athletic performance and may even create a hazardous situation. An intelligent choice of contact lens can provide some subtle advantages that may improve athletic performance and provide the decisive margin for victory.

  19. Protection from harmful UV radiation by contact lenses.

    PubMed

    Bergmanson, J P; Pitts, D G; Chu, L W

    1988-03-01

    Ultraviolet radiation (UVR) has been demonstrated to be harmful to the cornea, the lens and the retina. Recent research has indicated that, in addition to the epithelial trauma found in UVR-induced keratitis, the deeper corneal layers are also involved. Since trauma to keratocytes and endothelial cells can result in permanent damage or cell loss, it is imperative to protect eyes against excessive dosages of UVR. Standard hydrogel contact lenses (Vistamarc normal) and newly developed UV-filtering hydrogel lenses (Vistakon UV-BLOC) were fitted on five rabbits and compared in protection from harmful UVR (300 nm). The eyes that wore the UV-filtering lens maintained normal corneas; however, the eyes that wore the standard hydrogel lens showed pronounced epithelial, stromal and endothelial changes. We concluded that the UV-filtering lens effectively absorbed the hazardous UV radiation while the standard soft lens provided little protection.

  20. Accommodation in young adults wearing aspheric multifocal soft contact lenses

    NASA Astrophysics Data System (ADS)

    Lindskoog Pettersson, Anna; Wahlberg Ramsay, Marika; Lundström, Linda; Rosén, Robert; Nilsson, Maria; Unsbo, Peter; Brautaset, Rune

    2011-11-01

    The aim of the present project was to investigate accommodative behavior in young adults and adolescents fitted with an aspheric multifocal (center distance) contact lens with focus on evaluating whether these lenses can be an alternative treatment for subjects in which a reduced level of blur and thereby accommodation in near vision is aimed at. Twenty normal subjects aged between 21 and 35 years participated in the study. Aberrometry was perfomed using a Zywave™ aberrometer, first on the uncorrected eyes of all subjects, and again while the subjects wore a multifocal contact lens with a +1.00 add. A Shin-Nippon N Vision-K 5001 Autoref-Keratometer was used to measure accommodative response with two different refractive corrections: (1) habitual spectacle correction only, and (2) habitual correction and a aspheric multifocal (center distance) contact lens. Four hours of adaptation to the lens was allowed. The lag when wearing only the habitual spectacles was compared with the lag while wearing both the habitual spectacles and the aspheric multifocal contact lens. The mean lag of accommodation for the subject group was 0.85 D (±0.57 SD) and 0.75 D (±0.52 SD) without and with the multifocal lens, respectively. Statistical analyses showed no difference in lag (t = 0.8479, p = 0.407) with and without the lens. In conclusion, young normal subjects do not relax accommodation when fitted with aspheric multifocal center distance lenses when the addition is +1.00. It is therefore unlikely that subjects with accommodative ability, in whom the treatment purpose is to reduce blur and thereby accommodation, can be effectively treated with such lenses.

  1. Power Profiles of Commercial Multifocal Soft Contact Lenses

    PubMed Central

    Kim, Eon; Bakaraju, Ravi C.; Ehrmann, Klaus

    2017-01-01

    ABSTRACT Purpose To evaluate the optical power profiles of commercially available soft multifocal contact lenses and compare their optical designs. Methods The power profiles of 38 types of multifocal contact lenses—three lenses each—were measured in powers +6D, +3D, +1D, −1D, −3D, and −6D using NIMO TR1504 (Lambda-X, Belgium). All lenses were measured in phosphate buffered saline across 8 mm optic zone diameter. Refractive index of each lens material was measured using CLR 12-70 (Index Instruments, UK), which was used for converting measured power in the medium to in-air radial power profiles. Results Three basic types of power profiles were identified: center-near, center-distance, and concentric-zone ring-type designs. For most of the lens types, the relative plus with respect to prescription power was lower than the corresponding spectacle add. For some lens types, the measured power profiles were shifted by up to 1D across the power range relative to their labeled power. Most of the lenses were designed with noticeable amounts of spherical aberration. The sign and magnitude of spherical aberration can either be power dependent or consistent across the power range. Conclusions Power profiles can vary widely between the different lens types; however, certain similarities were also observed between some of the center-near designs. For the more recently released lens types, there seems to be a trend emerging to reduce the relative plus with respect to prescription power, include negative spherical aberration, and keep the power profiles consistent across the power range. PMID:27748699

  2. Cleaning and storage of rigid contact lenses prior to dispensing.

    PubMed

    MacMillan, T F; Benjamin, W J

    1992-05-01

    Most care regimens used with rigid contact lenses are composed of three solutions: 1) a "cleaning" solution; 2) a "combination" solution intended for storage, disinfection, and wetting prior to placement of rigid lenses on the eye; and 3) an in-eye "rewetting" or "lubricating" solution. While solutions (1) and (3) have only single functions, solution (2) must fulfill three fairly disparate functions. A "2-solution" care regimen is offered by Sherman Pharmaceuticals and consists of (a) a solution for cleaning, storage, and disinfection; and (b) a "wetting" solution that doubles as an in-eye lubricant. Through a more compatible and efficient matching of multiple functions within solutions, Sherman Pharmaceuticals claims to more adequately clean and prepare rigid gas-permeable (RGP) lens surfaces for wear. We investigated this strategy in terms of in-eye wettability of initially "ill-prepared" RGP lens surfaces, as measured with the in vivo contact angle technique. For this study, lenses were intentionally not cleaned of residues or solvents by the manufacturer at the end of production so as to create the well-known "first-day non-wetting syndrome." The ability of the 2-solution care regimen to even then provide wettable surfaces was compared to that of a saline control "regimen" and the most popular competing "3-solution" care system. We concluded that use of both care regimens dramatically enhanced in-eye wettability and, therefore, reduced the incidence of the "first-day non-wetting syndrome". However, the 2-solution care regimen provided significantly better wettability overall, lower incidence of functionally non-wetting surfaces, and more consistently wettable RGP lenses.

  3. Wide field-of-view bifocal eyeglasses

    NASA Astrophysics Data System (ADS)

    Barbero, Sergio; Rubinstein, Jacob

    2015-09-01

    When vision is affected simultaneously by presbyopia and myopia or hyperopia, a solution based on eyeglasses implies a surface with either segmented focal regions (e.g. bifocal lenses) or a progressive addition profile (PALs). However, both options have the drawback of reducing the field-of-view for each power position, which restricts the natural eye-head movements of the wearer. To avoid this serious limitation we propose a new solution which is essentially a bifocal power-adjustable optical design ensuring a wide field-of-view for every viewing distance. The optical system is based on the Alvarez principle. Spherical refraction correction is considered for different eccentric gaze directions covering a field-of-view range up to 45degrees. Eye movements during convergence for near objects are included. We designed three bifocal systems. The first one provides 3 D for far vision (myopic eye) and -1 D for near vision (+2 D Addition). The second one provides a +3 D addition with 3 D for far vision. Finally the last system is an example of reading glasses with +1 D power Addition.

  4. Bacteria and parasites in contact lenses of asymptomatic wearers in Nigeria

    PubMed Central

    Emina, Michael Osita; Idu, Faustina Kemdinum

    2011-01-01

    Purpose This is to determine the prevalence of bacterial and parasitic flora in asymptomatic disposable and extended contact lens wearers in Lagos State, Nigeria. Methods The study was carried out on 156 contact lenses from 78 asymptomatic wearers between the ages of 12 to 38 years. Eighty two disposable daily wear (DWCL) and 74 extended wear (EWCL) contact lenses were examined. The contact lenses’ swabs and the trays were transferred to the laboratory for microbial examination. Results Fifty two (70.27 %) extended wear contact lenses and 50 (60.98 %) disposable contact lenses examined were contaminated. Streptococcus spp. (4.23 %) were found in extended contact lenses and (3.9 %) in disposable contact lenses. Escherichia coli (15.49 %) were more in the extended contact lenses and were in higher proportion (14.74 %) than the other microorganisms in all the contact lenses. Klebsiella spp. (12.99 %) were more in the disposable lenses than in the extended wear lenses (12.69 %). there were more disposable lenses (41.56 %) with ‘no growth’. Amoebae were isolated from (6.49 %) disposable and (4.23 %) extended wear contact lenses. Seventeen (32.69 %) DWCL had mixed flora. There were significant differences between disposable and extended contact lenses, p < 0.05. Conclusions EWCL present more microorganisms and pose threat to the users. DWCL had more amoebae, which calls for suitable lens care methods. Further studies may be needed to determine the level of care required for contact lens users in developing countries.

  5. Measurement errors related to contact angle analysis of hydrogel and silicone hydrogel contact lenses.

    PubMed

    Read, Michael L; Morgan, Philip B; Maldonado-Codina, Carole

    2009-11-01

    This work sought to undertake a comprehensive investigation of the measurement errors associated with contact angle assessment of curved hydrogel contact lens surfaces. The contact angle coefficient of repeatability (COR) associated with three measurement conditions (image analysis COR, intralens COR, and interlens COR) was determined by measuring the contact angles (using both sessile drop and captive bubble methods) for three silicone hydrogel lenses (senofilcon A, balafilcon A, lotrafilcon A) and one conventional hydrogel lens (etafilcon A). Image analysis COR values were about 2 degrees , whereas intralens COR values (95% confidence intervals) ranged from 4.0 degrees (3.3 degrees , 4.7 degrees ) (lotrafilcon A, captive bubble) to 10.2 degrees (8.4 degrees , 12.1 degrees ) (senofilcon A, sessile drop). Interlens COR values ranged from 4.5 degrees (3.7 degrees , 5.2 degrees ) (lotrafilcon A, captive bubble) to 16.5 degrees (13.6 degrees , 19.4 degrees ) (senofilcon A, sessile drop). Measurement error associated with image analysis was shown to be small as an absolute measure, although proportionally more significant for lenses with low contact angle. Sessile drop contact angles were typically less repeatable than captive bubble contact angles. For sessile drop measures, repeatability was poorer with the silicone hydrogel lenses when compared with the conventional hydrogel lens; this phenomenon was not observed for the captive bubble method, suggesting that methodological factors related to the sessile drop technique (such as surface dehydration and blotting) may play a role in the increased variability of contact angle measurements observed with silicone hydrogel contact lenses.

  6. The effect of cleaning soft contact lenses. A scanning electron microscopic study.

    PubMed

    Fowler, S A; Allansmith, M R

    1981-08-01

    Scanning electron microscopy was used to investigate the effectiveness of surfactant and enzyme cleaners in removing coatings from soft contact lenses. We examined ten continuously worn lenses and 15 lenses worn and cleaned regularly for at six months. About 30% of the surface of continuously worn lenses cleaned with surfactant or enzyme was uncoated; smooth, matted coating covered the remainder. Continuously worn lenses cleaned with the combination surfactant and enzyme cleaner had similar deposits covering 50% of the surface. Lenses worn and cleaned regularly had more deposits after cleaning with surfactant or enzyme cleaner than after cleaning with combination cleaner. Approximately 25% of the surface of lenses cleaned with the combination was coated with deposits. The deposits on both types of lenses were about 30% less thick after use of the combination cleaner than with either single cleaner. The coating on worn contact lenses is not completely removed by any method we tested.

  7. Contact Lenses in Extreme Cold Environments: Response of Rabbit Corneas

    DTIC Science & Technology

    1981-04-15

    tion of temperature and wind produced wind-chill factors in the vicinity of -67.8°C, yet this acute exposure of the cornea to cold with and without...aqueous humor and intraocular temperature in rabbit and cat. Invest Ophthalmol Visual Sei 1978;17:1199-202. 6. Gülan JG. The cornea in Canada’s...5077 — "The effect of cold on the cornea while wearing contact lenses. It was submitted for review on 31 December 1980, approved for publication

  8. Use of Contact Lenses for Cold Weather Activities: Results of a Survey

    DTIC Science & Technology

    1981-12-17

    and preferred them over glasses. Lens care and handling were cited as problems. APPLICATION Contact lenses offer some advantages over spectacles ...vision. Contact lenses were generally comfortable in the cold, but lens care is difficult. Since they do not fog and they offer protection from wind...driven ice and snow, contact lenses offer an important advantage over spectacles . ill It is estimated that 50.3% of all Americans wear glasses1

  9. [Effect of welding arcs on the eyes of patients with contact lenses (literature study)].

    PubMed

    Stahler, D; Teubel, H; Karsten, H

    1989-01-01

    Two accidents had been reported from abroad, within which contact lense users grew blind after staying quite near at electrical arcs. It is supposed that the contact lenses had been "welded" with the cornea by influence of the electromagnetic radiation. Removal of lenses shall have caused the cornea "ablation" and thus the subjects permanent blindness. Nilsson et al. (1, 2, 5) performed intensive animal tests which proved, that contact lenses get hot in special spectral ranges thus underlying a certain drying up. The "welding" between contact lenses and the cornea could not be confirmed by test animals, but partial glueing of contact lenses and cornea and surface lesions of the epithelium as well in some cases. Hüer and Conrads (3, 4) experimenting on enucleated pigs' eyes, reported on similar results.

  10. Quantitation of cholesterol and phospholipid sorption on silicone hydrogel contact lenses.

    PubMed

    Pitt, William G; Perez, Krystian X; Tam, Ngai Keung; Handly, Erika; Chinn, Joseph A; Liu, Xiaojun Michael; Maziarz, Edmond Peter

    2013-11-01

    The introduction of silicone hydrogel (SiHy) contact lenses to the consumer marketplace necessitates study of the susceptibility of these lenses to spontaneous deposition by hydrophobic lipid components of ocular tears. The use of radioisotopes to measure lipid sorption on SiHy contact lenses gives precise and accurate results but requires institutional infrastructure and compels efficient lipid removal from the lens. This study compares three methods of quantitating phospholipid and cholesterol sorption on SiHy lenses using radiolabeled cholesterol and phosphatidylcholine that were sorbed on lenses from an artificial tear fluid. A triple extraction technique using n-propanol gives the most reliable results. Comparison of sorption on SiHy lenses shows that balafilcon A and senofilcon A lenses sorb similar amounts, while lotrafilcon B lenses sorb comparatively less.

  11. Oxygen permeability of soft contact lenses in different pH, osmolality and buffering solution

    PubMed Central

    Lee, Se Eun; Kim, So Ra; Park, Mijung

    2015-01-01

    AIM To determine the effect of pH, osmolality, and buffering system on the oxygen permeability (Dk) of soft contact lenses. METHODS Two hydrogel lenses (nelfilcon A and etafilcon A) and 2 silicone hydrogel lenses (lotrafilcon A and balafilcon A) were used in the study. These lenses were incubated in phosphate-buffered saline (PBS) and borate-buffered saline (BBS) solutions adjusted by 0.8 pH increments to a pH in the range of 5.8-9.0 or in hypotonic (280 mOsmol/kg), isotonic (310 mOsmol/kg) and hypertonic (380 mOsmol/kg) PBS solutions. Polarographic method was used for measuring the Dk and lenses were stacked as 4 layers to correct the boundary effect. RESULTS Dk values of all contact lenses measured in BBS solutions were more stable than those in PBS solutions. Especially the etafilcon A lens showed a relative big change compared with other types of contact lenses at the same conditions. When the osmolality of PBS solution increased from hypotonic to hypertonic, Dk of all contact lenses decreased. Variations in Dk existed depending on lens materials, etafilcon A lens was the most affected and nelfilcon A was the least affected by osmolality. CONCLUSION From the result obtained, it is revealed that Dk of contact lenses is changed by the pH, osmolality, and buffering condition of tear. Thus, Dk of contact lens can be varied by the lens wearers' physiological and/or pathological conditions. PMID:26558223

  12. Tear cytokine response to multipurpose solutions for contact lenses

    PubMed Central

    Kalsow, Carolyn M; Reindel, William T; Merchea, Mohinder M; Bateman, Kirk M; Barr, Joseph T

    2013-01-01

    Purpose An increased risk of corneal infiltrative events has been noted with the use of certain contact lenses and multipurpose solutions (MPS). This study was designed to evaluate tear cytokine assay as a sensitive, objective, and quantitative measure of the ocular surface response to contact lens/MPS and to consider the assay’s clinical relevance in the context of other measures of ocular surface response. Methods Two MPS, ReNu® Fresh™ (RNF) and Opti-Free® RepleniSH (OFR), were used with daily wear silicone hydrogel contact lenses in a randomized, prospective crossover study involving 26 subjects. Clinical data collection (conjunctival hyperemia, ocular surface sensitivity, solution induced corneal staining (SICS) test score, and subjective responses) and tear cytokine assays were conducted masked. Responses were tracked as change from baseline throughout the experimental schedule. Results Similar response patterns for several inflammatory cytokines were seen throughout both phases: subjects who received OFR in Phase I had mean tear concentrations that were generally higher than those of the RNF Phase I group. OFR Phase I subjects had significant (P < 0.01) increases over baseline at day 1 and/or following washout for 13 cytokines (cc chemokine ligands [CCL] 3, CCL5, CCL11, granulocyte-macrophage colony-stimulating factor [GM-CSF], interferon [INF]-γ, interleukin [IL]-2, IL-4, IL-5, IL-6, IL-13, IL-15, IL-17, tumor necrosis factor [TNF]-α). These changes were not observed in RNF Phase I subjects, even though SICS test scores increased. Phase I OFR subjects also had increased dryness, while RNF Phase I subjects had decreased bulbar hyperemia. No changes were detected with respect to limbal hyperemia or surface sensitivity thresholds. Conclusion The tear cytokine assay can detect and differentiate contact lens/MPS induced increases in inflammatory cytokines. Changes in cytokine levels were consistent with measurement of hyperemia and dryness but not with

  13. Producing optical (contact) lenses by a novel low cost process

    NASA Astrophysics Data System (ADS)

    Skipper, Richard S.; Spencer, Ian D.

    2005-09-01

    The rapid and impressive growth of China has been achieved on the back of highly labour intensive industries, often in manufacturing, and at the cost of companies and jobs in Europe and America. Approaches that worked well in the 1990's to reduce production costs in the developed countries are no longer effective when confronted with the low labour costs of China and India. We have looked at contact lenses as a product that has become highly available to consumers here but as an industry that has reduced costs by moving to low labour cost countries. The question to be answered was, "Do we have the skill to still make the product in the UK, and can we make it cheap enough to export to China?" if we do not, then contact lens manufacture will move to China sooner or later. The challenge to enter the markets of the BRIC (Brazil, Russia, India and China) countries is extremely exciting as here is the new money, high growth and here is a product that sells to those with disposable incomes. To succeed we knew we had to be radical in our approach; the radical step was very simple: to devise a process in which each step added value to the customer and not cost to the product. The presentation examines the processes used by the major producers and how, by applying good manufacturing practice sound scientific principles to them, the opportunity to design a new low cost patented process was identified.

  14. Isolation and identification of biologically active contaminants from soft contact lenses. I. Nicotine deposits on worn lenses.

    PubMed

    Broich, J R; Weiss, L; Rapp, J

    1980-11-01

    A method for elution of contaminants deposited onto soft contact lenses during wear utilizing a nondestructive cleaning procedure is presented. Twenty-five soft contact lenses supplied by American Optical Corp. were pooled and subjected to 20% H2O2 (hydrogen peroxide). The resulting wash was extracted with organic solvents, hydrolyzed, and re-extracted. The organic-soluble fraction was further divided into strong acids, intermediate acids, neutrals, and bases. Sequential separation, isolation, characterization, and confirmation of constituents were achieved with thin-layer chromatography, ultraviolet spectrophotometry, and microcrystallography. Photomicrographs before and after cleaning were obtained to assess the optical quality of the lenses. Initial emphasis has been to characterize naturally occurring, biologically active constituents and common environmental toxins of molecular weight 150 to 500. We find that nicotine, a common environmental pollutant and a significant component of the blood of people who smoke regularly, is one of the contaminants present on a worn soft contact lens.

  15. Design and Fabrication of Functional Contact Lenses with Integrated Light Emitting and Photovoltaic Components

    NASA Astrophysics Data System (ADS)

    Lingley, Andrew

    This dissertation presents progress toward the realization of functional contact lenses. Two primary goals of the functional contact lens project are to create displays for augmented reality and to create sensors to measure biomolecules in tears. First, work on contact lens displays is described, detailing the steps and process optimization required to fabricate fully functional contact lenses and culminating in the wireless activation of a single pixel contact lens display in vivo on a rabbit under general anesthesia. Next, solar cells designed to conform to a sphere for use with contact lens biosensors are described. To measure analytes in the tear film using electrochemical methods, contact lenses would require embedded sensors, electronics, antennas or LEDs for communication, and power sources. Ideally, a contact lens biosensor would be autonomous, provide regular readings, and operate during normal daily activity, thus requiring power continuously. Photovoltaic structures could provide continuous power for autonomous contact lens systems that could store sensor readings and communicate data when occasionally queried.

  16. Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome.

    PubMed

    Maulvi, Furqan A; Soni, Tejal G; Shah, Dinesh O

    2015-01-01

    Current dry eye treatment includes delivering comfort enhancing agents to the eye via eye drops, but low residence time of eye drops leads to low bioavailability. Frequent administration leads to incompliance in patients, so there is a great need for medical device such as contact lenses to treat dry eye. Studies in the past have demonstrated the efficacy of hyaluronic acid (HA) in the treatment of dry eyes using eye drops. In this paper, we present two methods to load HA in hydrogel contact lenses, soaking method and direct entrapment. The contact lenses were characterized by studying their optical and physical properties to determine their suitability as extended wear contact lenses. HA-laden hydrogel contact lenses prepared by soaking method showed release up to 48 h with acceptable physical and optical properties. Hydrogel contact lenses prepared by direct entrapment method showed significant sustained release in comparison to soaking method. HA entrapped in hydrogels resulted in reduction in % transmittance, sodium ion permeability and surface contact angle, while increase in % swelling. The impact on each of these properties was proportional to HA loading. The batch with 200-μg HA loading showed all acceptable values (parameters) for contact lens use. Results of cytotoxicity study indicated the safety of hydrogel contact lenses. In vivo pharmacokinetics studies in rabbit tear fluid showed dramatic increase in HA mean residence time and area under the curve with lenses in comparison to eye drop treatment. The study demonstrates the promising potential of delivering HA through contact lenses for the treatment of dry eye syndrome.

  17. Rigid gas permeable contact lenses surface roughness examined by interferential shifting phase and scanning electron microscopies.

    PubMed

    Merindano, M D; Canals, M; Saona, C; Costa, J

    1998-01-01

    The anterior surface roughness of seven factory new rigid gas permeable (RGP) contact lenses has been studied by interferential shifting phase microscopy (ISPM) and scanning electron microscopy (SEM). Five lenses were fluorsilicone acrylate and two lenses were silicone acrylate. Their material Dk ranged from 14 to 210. ISPM is shown to be a reliable and non-destructive method to observe and measure the relief of the contact lens surface. Moreover, profile and contour data are easily stored for further quantitative studies. ISPM contour patterns of the studied lenses are qualitatively compared with those obtained by SEM for the same lenses. Results point out that ISPM gives similar accuracy but it is non-destructive and cheaper than SEM. Moreover, the quantitative study of surface roughness suggests that there is a relationship between surface roughness and Dk of the lens material: surface roughness increases with Dk and allows to distinguish between lenses with low, medium and high Dk.

  18. Short-Term Neural Adaptation to Simultaneous Bifocal Images

    PubMed Central

    Radhakrishnan, Aiswaryah; Dorronsoro, Carlos; Sawides, Lucie; Marcos, Susana

    2014-01-01

    Simultaneous vision is an increasingly used solution for the correction of presbyopia (the age-related loss of ability to focus near images). Simultaneous Vision corrections, normally delivered in the form of contact or intraocular lenses, project on the patient's retina a focused image for near vision superimposed with a degraded image for far vision, or a focused image for far vision superimposed with the defocused image of the near scene. It is expected that patients with these corrections are able to adapt to the complex Simultaneous Vision retinal images, although the mechanisms or the extent to which this happens is not known. We studied the neural adaptation to simultaneous vision by studying changes in the Natural Perceived Focus and in the Perceptual Score of image quality in subjects after exposure to Simultaneous Vision. We show that Natural Perceived Focus shifts after a brief period of adaptation to a Simultaneous Vision blur, similar to adaptation to Pure Defocus. This shift strongly correlates with the magnitude and proportion of defocus in the adapting image. The magnitude of defocus affects perceived quality of Simultaneous Vision images, with 0.5 D defocus scored lowest and beyond 1.5 D scored “sharp”. Adaptation to Simultaneous Vision shifts the Perceptual Score of these images towards higher rankings. Larger improvements occurred when testing simultaneous images with the same magnitude of defocus as the adapting images, indicating that wearing a particular bifocal correction improves the perception of images provided by that correction. PMID:24664087

  19. Design and verifications of an eye model fitted with contact lenses for wavefront measurement systems

    NASA Astrophysics Data System (ADS)

    Cheng, Yuan-Chieh; Chen, Jia-Hong; Chang, Rong-Jie; Wang, Chung-Yen; Hsu, Wei-Yao; Wang, Pei-Jen

    2015-09-01

    Contact lenses are typically measured by the wet-box method because of the high optical power resulting from the anterior central curvature of cornea, even though the back vertex power of the lenses are small. In this study, an optical measurement system based on the Shack-Hartmann wavefront principle was established to investigate the aberrations of soft contact lenses. Fitting conditions were micmicked to study the optical design of an eye model with various topographical shapes in the anterior cornea. Initially, the contact lenses were measured by the wet-box method, and then by fitting the various topographical shapes of cornea to the eye model. In addition, an optics simulation program was employed to determine the sources of errors and assess the accuracy of the system. Finally, samples of soft contact lenses with various Diopters were measured; and, both simulations and experimental results were compared for resolving the controversies of fitting contact lenses to an eye model for optical measurements. More importantly, the results show that the proposed system can be employed for study of primary aberrations in contact lenses.

  20. Ocular Drug Delivery through pHEMA-Hydrogel Contact Lenses Co-Loaded with Lipophilic Vitamins

    PubMed Central

    Lee, Dasom; Cho, Seungkwon; Park, Hwa Sung; Kwon, Inchan

    2016-01-01

    Ocular drug delivery through hydrogel contact lenses has great potential for the treatment of ocular diseases. Previous studies showed that the loading of lipophilic vitamin E to silicone-hydrogel contact lenses was beneficial in ocular drug delivery. We hypothesized that vitamin E loading to another type of popular hydrogel contact lenses, pHEMA-hydrogel contact lenses, improves ocular drug delivery by increasing the drug loading or the duration of drug release. Loading of vitamin E to pHEMA-hydrogel contact lenses significantly increased the loading of a hydrophilic drug surrogate (Alexa Fluor 488 dye) and two hydrophilic glaucoma drugs (timolol and brimonidine) to the lenses by 37.5%, 19.1%, and 18.7%, respectively. However, the release duration time was not significantly altered. Next, we hypothesized that the lipophilic nature of vitamin E attributes to the enhanced drug loading. Therefore, we investigated the effects of co-loading of another lipophilic vitamin, vitamin A, on drug surrogate delivery. We found out that vitamin A loading also increased the loading of the drug surrogate to pHEMA-hydrogel contact lenses by 30.3%. Similar to vitamin E loading, vitamin A loading did not significantly alter the release duration time of the drug or drug surrogate. PMID:27678247

  1. Ocular Drug Delivery through pHEMA-Hydrogel Contact Lenses Co-Loaded with Lipophilic Vitamins

    NASA Astrophysics Data System (ADS)

    Lee, Dasom; Cho, Seungkwon; Park, Hwa Sung; Kwon, Inchan

    2016-09-01

    Ocular drug delivery through hydrogel contact lenses has great potential for the treatment of ocular diseases. Previous studies showed that the loading of lipophilic vitamin E to silicone-hydrogel contact lenses was beneficial in ocular drug delivery. We hypothesized that vitamin E loading to another type of popular hydrogel contact lenses, pHEMA-hydrogel contact lenses, improves ocular drug delivery by increasing the drug loading or the duration of drug release. Loading of vitamin E to pHEMA-hydrogel contact lenses significantly increased the loading of a hydrophilic drug surrogate (Alexa Fluor 488 dye) and two hydrophilic glaucoma drugs (timolol and brimonidine) to the lenses by 37.5%, 19.1%, and 18.7%, respectively. However, the release duration time was not significantly altered. Next, we hypothesized that the lipophilic nature of vitamin E attributes to the enhanced drug loading. Therefore, we investigated the effects of co-loading of another lipophilic vitamin, vitamin A, on drug surrogate delivery. We found out that vitamin A loading also increased the loading of the drug surrogate to pHEMA-hydrogel contact lenses by 30.3%. Similar to vitamin E loading, vitamin A loading did not significantly alter the release duration time of the drug or drug surrogate.

  2. Contact lenses as the best conservative treatment of newly diagnosed keratoconus--epidemiological retrospective study.

    PubMed

    Mrazovac, Danijela; Barisić Kutija, Marija; Vidas, Sania; Kuzman, Tomislav; Petricek, Igor; Jandroković, Sonja; Kalauz, Miro; Cerovski, Branimir

    2014-12-01

    Keratoconus is a progressive, non-inflammatory corneal ectasia characterized by thinning and weakening of the corneal stroma which results in its' protrusion. The onset is during puberty and progresses until the fourth decade of life. In earlier stages, good visual acuity can be provided with spectacles. With progression, contact lenses are considered to be a better therapy. Aim of this study was to determine if there is statistically significant difference between best corrected visual acuity (BCVA) obtained by spectacles and contact lenses in newly diagnosed keratoconus patients, as well as to determine which type of contact lenses provide better BCVA in keratoconus patients. We conducted a 5-year retrospective study of all 2891 patients attending our Contact Lens Department for the first time, searching for patients newly diagnosed with keratoconus. Data were obtained on gender, age, education level, treated eyes, corneal changes, keratoconus severity, BCVA with spectacles, contact lenses and best fitted contact lens type. All patients underwent standard ophthalmic exam, refractometry and keratometry have been done, followed by a spectacles correction and lens fitting. Wilcoxon signed rank test was used for statistical analysis. Results showed that of all 2891 patients examined for the first time, 137 patients (4.74%) have been newly diagnosed with heratoconus, there was male bias (72.26%), mean age 27.7 +/- 9.9 years. Most patients had high school education (51.11%), 3.70% had present corneal changes, 50.37% had mild heratoconus. Majority had keratoconus on both eyes (36.3%) or keratoconus of right eye (26.67%). There was a statistically significant difference (p<0.001) between the BCVA obtained with contact lenses (0.82 +/- 0.21 Snellen chart) rather than spectacles (0.37 +/- 0.27 Snellen chart). The best corrected visual acuity was achieved with rigid gas permeable (RGP) lenses in majority of kera- toconus eyes (51.85%), with semi-gas permeable (SGP) lenses

  3. The Use of Extended Wear Contact Lenses in the Aviation Environment: An Army-wide Study.

    DTIC Science & Technology

    1992-09-01

    display devices often can present a compatibility problem with spectacles ; the use of specialized environmental protective systems can further confound this...involving the test subjects. Subjective performance assessments rated the contact lenses utilized as being superior to spectacle wear for a vast majority...The affected aviators merely wore their spectacles in lieu of the contact lenses . A total of 6 of the original 44 subjects were unable to complete

  4. METHOD FOR PRODUCING WETTABLE SURFACES ON CONTACT LENSES BY CHEMICAL FORMATION OF INORGANIC FILMS

    DTIC Science & Technology

    Wettable surfaces of a permanent nature can be produced on contact lenses by means of the technic of chemical deposition of an inorganic film on the...immersion resistance. Stepwise instructions are given for the preparation of hydrophilic surfaces on contact lenses . The equipment developed for this work is relatively simple and inexpensive. (Author)...lens surface. The process is simpler, both in apparatus and procedure, than the vacuum deposition technic designed earlier for producing wettable

  5. Changes in corneal thickness under four different rigid gas permeable contact lenses for daily wear.

    PubMed

    Vreugdenhil, W; Eggink, F A; Beekhuis, W H; Theeuwes, A

    1990-09-01

    The relation between corneal thickness changes and the Dk value of rigid contact lenses was investigated in 42 patients who were fitted with contact lenses for the first time. These 42 patients were divided into 4 groups that were fitted with contact lenses of different Dk values. Corneal thickness in the open-eye state was measured (mid-afternoon) before contact lens fitting and after 6 weeks of daily contact lens wear. The changes in corneal thickness were not significantly different among the 4 contact lens materials (Dk values 8, 26, 54, and 92). We conclude that for daily wear use the lower Dk materials meet corneal requirements. However, there is a significant trend; the higher Dk values result in a thinner cornea. Causes for this phenomenon are discussed.

  6. Infantile nystagmus syndrome: Broadening the high-foveation-quality field with contact lenses

    PubMed Central

    Taibbi, Giovanni; Wang, Zhong I; Dell’Osso, Louis F

    2008-01-01

    We investigated the effects of contact lenses in broadening and improving the high-foveation-quality field in a subject with infantile nystagmus syndrome (INS). A high-speed, digitized video system was used for the eye-movement recording. The subject was asked to fixate a far target at different horizontal gaze angles with contact lenses inserted. Data from the subject while fixating at far without refractive correction and at near (at a convergence angle of 60 PD), were used for comparison. The eXpanded Nystagmus Acuity Function (NAFX) was used to evaluate the foveation quality at each gaze angle. Contact lenses broadened the high-foveation-quality range of gaze angles in this subject. The broadening was comparable to that achieved during 60 PD of convergence although the NAFX values were lower. Contact lenses allowed the subject to see “more” (he had a wider range of high-foveation-quality gaze angles) and “better” (he had improved foveation at each gaze angle). Instead of being contraindicated by INS, contact lenses emerge as a potentially important therapeutic option. Contact lenses employ afferent feedback via the ophthalmic division of the V cranial nerve to damp INS slow phases over a broadened range of gaze angles. This supports the proprioceptive hypothesis of INS improvement. PMID:19668758

  7. Ultraviolet (UV) transmittance characteristics of daily disposable and silicone hydrogel contact lenses.

    PubMed

    Moore, Linda; Ferreira, Jannie T

    2006-07-01

    The ultraviolet (UV) transmittance spectra of daily wear hydrogel and disposable silicone hydrogel contact lenses were measured. Average transmittance percentages were calculated for each lens for the entire UV spectrum and individually for the UVC, UVB and UVA portions of the spectrum. The significance of the differences in transmittance spectra obtained for the lenses was analysed using a one-way ANOVA planned comparisons test (alpha=0.05). The transmittance data were then used to calculate a UV protection factor (PF) for each contact lens brand tested. The PFs for 1-DAY ACUVUE MOIST (6.22), ACUVUE ADVANCE (10.02) and ACUVUE OASYS (11.96) contact lenses show that these contact lenses have superior UV-blocking capabilities. The PFs for Focus DAILIES (1.79), SofLens 1-day disposables (1.72), NIGHT & DAY (1.84), O2 Optix (1.99) and Purevision (2.62) show that these contact lenses posses more modest UV-blocking characteristics. This paper reviews the importance of protection of the anterior ocular surface from UV damage and quantifies the protection afforded by selected commercially available disposable contact lenses.

  8. Objective assessment of the effect of pupil size upon the power distribution of multifocal contact lenses

    PubMed Central

    Papadatou, Eleni; Del Águila-Carrasco, Antonio J.; Esteve-Taboada, José J.; Madrid-Costa, David; Cerviño-Expósito, Alejandro

    2017-01-01

    AIM To analytically assess the effect of pupil size upon the refractive power distributions of different designs of multifocal contact lenses. METHODS Two multifocal contact lenses of center-near design and one multifocal contact lens of center-distance design were used in this study. Their power profiles were measured using the NIMO TR1504 device (LAMBDA-X, Belgium). Based on their power profiles, the power distribution was assessed as a function of pupil size. For the high addition lenses, the resulting refractive power as a function of viewing distance (far, intermediate, and near) and pupil size was also analyzed. RESULTS The power distribution of the lenses was affected by pupil size differently. One of the lenses showed a significant spread in refractive power distribution, from about −3 D to 0 D. Generally, the power distribution of the lenses expanded as the pupil diameter became greater. The surface of the lens dedicated for each distance varied substantially with the design of the lens. CONCLUSION In an experimental basis, our results show how the lenses power distribution is affected by the pupil size and underlined the necessity of careful evaluation of the patient's visual needs and the optical properties of a multifocal contact lens for achieving the optimal visual outcome. PMID:28149785

  9. Physicochemical factors influencing bacterial transfer from contact lenses to surfaces with different roughness and wettability.

    PubMed

    Vermeltfoort, Pit B J; van der Mei, Henny C; Busscher, Henk J; Hooymans, Johanna M M; Bruinsma, Gerda M

    2004-11-15

    The aim of this study was to determine the transfer of Pseudomonas aeruginosa No. 3 and Staphylococcus aureus 835 from contact lenses to surfaces with different hydrophobicity and roughness. Bacteria were allowed to adhere to contact lenses (Surevue, PureVision, or Focus Night & Day) by incubating the lenses in a bacterial suspension for 30 min. The contaminated lenses were put on a glass, poly(methylmethacrylate), or silicone rubber substratum, shaped to mimic the eye. After 2 and 16 h, lenses were separated from the substrata and bacteria were swabbed off from the respective surfaces and resuspended in saline. Appropriate serial dilutions of these suspensions were made, from which aliquots were plated on agar for enumeration. Bacterial transfer varied between 4 and 60%, depending on the combination of strain, contact time, contact lens, and substratum surface. For P. aeruginosa No. 3, transfer was significantly higher after 16 h than after 2 h, whereas less increase with time was seen for S. aureus 835. Bacterial transfer from all tested contact lenses was least to silicone rubber, the most hydrophobic and roughest substratum surface included.

  10. Advanced manual lensometry: a self-learning guide for evaluating multifocal and specialty lenses, progressive lenses, prisms, and rigid contact lenses.

    PubMed

    Garber, N

    2000-01-01

    Advanced manual lensometry techniques are required when automated lensometry may not be appropriate for reading special lenses or rigid contact lenses. These advanced techniques are challenging but provide accurate diagnostic and lens verification data. One should never assume that the glasses the patient is wearing match what the doctor prescribed. The prescription should be checked at least once, even when there are no patient complaints. If possible, learn and practice these special procedures under the supervision of an optician or ophthalmic clinical trainer. This will help to verify that you are performing these special techniques correctly.

  11. Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses.

    PubMed

    Omali, Negar Babaei; Subbaraman, Lakshman N; Coles-Brennan, Chantal; Fadli, Zohra; Jones, Lyndon W

    2015-07-01

    Within a few minutes of wear, contact lenses become rapidly coated with a variety of tear film components, including proteins, lipids, and mucins. Tears have a rich and complex composition, allowing a wide range of interactions and competitive processes, with the first event observed at the interface between a contact lens and tear fluid being protein adsorption. Protein adsorption on hydrogel contact lenses is a complex process involving a variety of factors relating to both the protein in question and the lens material. Among tear proteins, lysozyme is a major protein that has both antibacterial and anti-inflammatory functions. Contact lens materials that have high ionicity and high water content have an increased affinity to accumulate lysozyme during wear, when compared with other soft lens materials, notably silicone hydrogel lenses. This review provides an overview of tear film proteins, with a specific focus on lysozyme, and examines various factors that influence protein deposition on contact lenses. In addition, the impact of lysozyme deposition on various ocular physiological responses and bacterial adhesion to lenses and the interaction of lysozyme with other tear proteins are reviewed. This comprehensive review suggests that deposition of lysozyme on contact lens materials may provide a number of beneficial effects during contact lens wear.

  12. Contact lenses and the rate of evaporation measured in vitro; the influence of wear, squalene and wax.

    PubMed

    Vishnubhatla, Sravya; Borchman, Douglas; Foulks, Gary N

    2012-12-01

    Accelerated evaporation of tears may contribute to dry eye symptoms. It is not clear whether contact lenses decrease or increase the rate of evaporation of tears. In this study, the rates of evaporation through contact lenses (ERTCL) were measured in vitro to gain insight to this question. Contact lenses were equilibrated with various solutions to determine if they influenced ERTCL in vitro. ERTCL was measured gravimetrically. ERTCL measured in vitro for used contact lenses was about 20% faster than for buffer alone suggesting that natural tear components bound to the lenses changed the ERTCL. One natural tear component that binds to contact lenses is waxes. Equilibration of contact lenses with wax increased the ERTCL by about 30% suggesting that waxes might potentially increase ERTCL in vivo. Squalene, found in sebum and possibly meibum was infused into the contact lenses as a step toward decreasing the ERTCL. Squalene decreased ERTCL by over 60% in vitro. Soaking a contact lens in DuraSite(®) with benzalkonium chloride (BAK) did not alter the ERTCL. ERTCL were about 40% higher than the evaporation rate of DuraSite(®) alone or without BAK. In addition to lowering the ERTCL, the squalene in contact lenses could be a source of terpenoids to replace the terpenoids deficient in patients with MGD. If the ERTCL could be minimized in vivo, contact lenses could potentially be used to relieve dry eye symptoms in patients with evaporative dry eye.

  13. Oxygen, water, and sodium chloride transport in soft contact lenses materials.

    PubMed

    Gavara, Rafael; Compañ, Vicente

    2016-07-21

    Oxygen permeability, diffusion coefficient of the sodium ions and water flux and permeability in different conventional hydrogel (Hy) and silicone-hydrogel (Si-Hy) contact lenses have been measured experimentally. The results showed that oxygen permeability and transmissibility requirements of the lens have been addressed through the use of siloxane containing hydrogels. In general, oxygen and sodium chloride permeability values increased with the water content of the lens but there was a percolation phenomenon from a given value of water uptake mainly in the Si-Hy lenses which appeared to be related with the differences between free water and bound water contents. The increase of ion permeability with water content did not follow a unique trend indicating a possible dependence of the chemical structure of the polymer and character ionic and non-ionic of the lens. Indeed, the salt permeability values for silicone hydrogel contact lenses were one order of magnitude below those of conventional hydrogel contact lenses, which can be explained by a diffusion of sodium ions occurring only through the hydrophilic channels. The increase of the ionic permeability in Si-Hy materials may be due to the confinement of ions in nanoscale water channels involving possible decreased degrees of freedom for diffusion of both water and ions. In general, ionic lenses presented values of ionic permeability and diffusivity higher than most non-ionic lenses. The tortuosity of the ionic lenses is lower than the non-ionic Si-Hy lenses. Frequency 55 and PureVision exhibited the highest water permeability and flux values and, these parameters were greater for ionic Si-Hy lenses than for ionic conventional hydrogel lenses. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.

  14. Influence of Tear Protein Deposition on the Oxygen Permeability of Soft Contact Lenses

    PubMed Central

    2017-01-01

    Purpose. To investigate the effect of tear protein deposition on the change in oxygen permeability (Dk) of soft contact lenses (SCL). Methods. Three hydrogel lenses (polymacon, nelfilcon A, and etafilcon A) and two silicon hydrogel lenses (lotrafilcon A and balafilcon A) were investigated. Etafilcon A lenses were incubated in artificial tear solution for 1, 6, 12, and 48 h, whereas the other SCL were incubated for 1, 3, 7, and 14 days. Oxygen permeability was measured using the polarographic method, and lenses were stacked in four layers to correct the boundary effect. Results. The Dk of all investigated SCL was decreased by the protein deposition. Silicone hydrogel lenses showed a smaller deposition of artificial tear proteins than conventional hydrogel lenses. However, their Dk was reduced twofold than those of 3 conventional hydrogel lenses when compared at the same level of protein deposition. Despite a large amount of total deposited protein in etafilcon A lenses, their Dk was more stable than other SCL. Conclusions. From the results, it was revealed that the Dk of SCL is different from the value provided by manufacturers because of the tear protein deposition on surface and/or in pore of SCL; however, the degree of Dk change in SCL was not simply correlated with the amount of tear protein deposition. Thus, it is considered that the correlation between tear protein deposition and properties of lens materials affects Dk change. PMID:28280635

  15. Effect of surfactant chain length on drug release kinetics from microemulsion-laden contact lenses.

    PubMed

    Maulvi, Furqan A; Desai, Ankita R; Choksi, Harsh H; Patil, Rahul J; Ranch, Ketan M; Vyas, Bhavin A; Shah, Dinesh O

    2017-03-31

    The effect of surfactant chain lengths [sodium caprylate (C8), Tween 20 (C12), Tween 80 (C18)] and the molecular weight of block copolymers [Pluronic F68 and Pluronic F 127] were studied to determine the stability of the microemulsion and its effect on release kinetics from cyclosporine-loaded microemulsion-laden hydrogel contact lenses in this work. Globule size and dilution tests (transmittance) suggested that the stability of the microemulsion increases with increase in the carbon chain lengths of surfactants and the molecular weight of pluronics. The optical transmittance of direct drug-laden contact lenses [DL-100] was low due to the precipitation of hydrophobic drugs in the lenses, while in microemulsion-laden lenses, the transmittance was improved when stability of the microemulsion was achieved. The results of in vitro release kinetics revealed that drug release was sustained to a greater extent as the stability of microemulsion was improved as well. This was evident in batch PF127-T80, which showed sustained release for 15days in comparison to batch DL-100, which showed release up to 7days. An in vivo drug release study in rabbit tear fluid showed significant increase in mean residence time (MRT) and area under curve (AUC) with PF-127-T80 lenses (stable microemulsion) in comparison to PF-68-SC lenses (unstable microemulsion) and DL-100 lenses. This study revealed the correlation between the stability of microemulsion and the release kinetics of drugs from contact lenses. Thus, it was inferred that the stable microemulsion batches sustained the release of hydrophobic drugs, such as cyclosporine from contact lenses for an extended period of time without altering critical lens properties.

  16. Feasibility of corneal drug delivery of cysteamine using vitamin E modified silicone hydrogel contact lenses.

    PubMed

    Hsu, Kuan-Hui; Fentzke, Richard C; Chauhan, Anuj

    2013-11-01

    Cystinosis is an inherited genetic disease characterized by the accumulation of cystine crystals in several tissues including the cornea. The corneal manifestations of cystinosis are treated by hourly instillation of cysteamine eye drops each day while awake. The high frequency of eye drop instillation along with the long duration of treatment leads to poor compliance in many patients. We have combined in vitro experiments with mathematical modeling to investigate the feasibility of daily use of cysteamine loaded contact lenses to replace the hourly instillation of drops. Our approach was based on incorporation of vitamin E diffusion barriers into commercially available contact lenses to increase the duration of drug release. Contact lenses were first soaked in a solution of vitamin E in ethanol. Subsequently, the lenses were soaked in an aqueous solution of cysteamine to load the drug. The drug release profiles from vitamin E treated lenses were measured under sink conditions. In addition, drug oxidation rates were measured after exposing drug loaded contact lenses to humidified room air. To study further the feasibility of using contact lenses for the delivery of cysteamine, a mass transfer model was used to determine the rates at which the drug loaded in the lens is delivered to the cornea. The results show that vitamin E loading increases the release duration from 10 min to about 3 h in solution, thus allowing the possibility of extended drug delivery. In addition to improving the release profiles, vitamin E loading also improved the drug stability by reducing the oxidation rates. The mathematical modeling of drug transport in the eye suggested that the vitamin E loaded contact lens can provide the daily therapeutic dose without causing toxicity, while significantly increasing the bioavailability compared to eye drops. Based on the in vitro experimental results and the mathematical modeling, it is likely that a single contact lens worn for about 2h could

  17. Studying functional properties of hydrogel and silicone-hydrogel contact lenses with PALS, MIR and Raman spectroscopy.

    PubMed

    Filipecki, J; Sitarz, M; Kocela, A; Kotynia, K; Jelen, P; Filipecka, K; Gaweda, M

    2014-10-15

    Determination of free volume holes of the hydrogel and silicone-hydrogel polymer contact lenses were investigated. Two types of polymer contact lenses were used as materials: the first is a hydrogel contact lenses Proclear family (Omafilcon A), while the second is a silicone-hydrogel contact lens of the family Biofinity (Comfilcon A). Positron annihilation lifetime spectroscopy PALS was used to characterize geometrical sizes and fraction of the free volume holes in the investigated samples. There is a clear difference in the free volume sizes and their fractions between silicone-hydrogel and polymer hydrogel contact lenses which in turn are connected with oxygen permeability in these lenses. Apart from that, spectroscopic (middle infrared) MIR and Raman examinations were carried out in order to demonstrate the differences of the water content in the test contact lenses.

  18. Dual drug delivery from vitamin E loaded contact lenses for glaucoma therapy.

    PubMed

    Hsu, Kuan-Hui; Carbia, Blanca E; Plummer, Caryn; Chauhan, Anuj

    2015-08-01

    Glaucoma patients frequently instill eye drops multiple times each day, which is a cause for reduced compliance. Additionally, eye drops suffer from other limitations including low bioavailability, which can lead to side effects. We propose to develop drug-eluting contact lenses for managing glaucoma with increased bioavailability and improved compliance. Contact lenses are developed for extended simultaneous release of timolol and dorzolamide, both of which are commonly prescribed hydrophilic drugs. The extended release is achieved by loading lenses with vitamin E barriers. In vitro release studies are performed with control and vitamin E loaded lenses for both drugs loaded separately and then together in the same lens. The safety and efficacy of combination therapy by contacts are demonstrated in a Beagle model of glaucoma. Simultaneous loading of timolol and dorzolamide increases the release duration of both drugs. Also vitamin E incorporation is highly effective in increasing the release durations of both drugs to about 2-days. The lenses loaded with both drugs exhibited superior IOP reduction compared to eye drops with about 6-fold lower drug loading. More importantly, combination therapy by continuous wear of vitamin E loaded contact for 2-days, followed by a new set of contacts for another two days, reduced IOP during the 4days of wear time and for another 8days after removal of the contacts. Vitamin E loading is very effective for providing combination therapy by contact lenses due to the increase in release durations of several drugs. The contact lens based therapy reduces IOP with lower drug dose compared to eye drops and may significantly improve the compliance as the effect of the therapy lasts significantly longer than the wear-duration.

  19. [The application of highly hydrophilic contact lenses in the Fuchs-Steven-Johnson syndrome (author's transl)].

    PubMed

    Schulz, E

    1979-01-01

    In 3 patients with status after Fuchs-Steven-Johnson syndrome highly hydrophilic contact lenses (72% H2O-up take) were adapted and worn permanently. 2 patients had worn already for a long time usual HEMA-lenses. The lenses showed themselves to be favorable against mechanical irritation from cilia and accessory eyelashes and from scarring conjunctival conditions, and they affected favorably the signs of dessication of the cornea. Corneal defects healed, and the patients had subjectively no complaints. It is sometimes necessary to replace the tears. An increase in the corneal vascularisation already present could not be observed during the 18 months observation time.

  20. Enzymatic Quantification of Cholesterol and Cholesterol Esters from Silicone Hydrogel Contact Lenses

    PubMed Central

    Pucker, Andrew D.; Thangavelu, Mirunalni

    2010-01-01

    Purpose. The purpose of this work was to develop an enzymatic method of quantification of cholesterol and cholesterol esters derived from contact lenses, both in vitro and ex vivo. Methods. Lotrafilcon B (O2 Optix; CIBA Vision, Inc., Duluth, GA) and galyfilcon A (Acuvue Advance; Vistakon, Inc., Jacksonville, FL) silicone hydrogel contact lenses were independently incubated in cholesterol oleate solutions varying in concentrations. After incubation, the lenses were removed and underwent two separate 2:1 chloroform-methanol extractions. After in vitro studies, 10 human subjects wore both lotrafilcon B and galyfilcon A contact lenses for 7 days. The lenses also underwent two separate 2:1 chloroform-methanol extractions. All in vitro and ex vivo samples were quantified with a cholesterol esterase enzymatic reaction. Results. Calibration curves from quantifications of in vitro contact lens samples soaked in successively decreasing concentrations of cholesterol oleate yielded coefficients of determination (R2) of 0.99 (lotrafilcon B) and 0.97 (galyfilcon A). For in vitro contact lens samples, galyfilcon A was associated with an average cholesterol oleate extraction of 39.85 ± 48.65 μg/lens, whereas lotrafilcon B was associated with 5.86 ± 3.36 μg/lens (P = 0.05) across both extractions and all incubation concentrations. For ex vivo contact lens samples, there was significantly more cholesterol and cholesterol esters deposited on galyfilcon A (5.77 ± 1.87 μg/lens) than on lotrafilcon B (2.03 ± 1.62 μg/lens; P = 0.0005). Conclusions. This is an efficient and simple method of quantifying total cholesterol extracted from silicone hydrogel contact lenses and, potentially, the meibum and/or tear film. Certain silicone hydrogel materials demonstrate more affinity for cholesterol and its esters than do others. PMID:20089871

  1. Automatic detection of non-cosmetic soft contact lenses in ocular images

    NASA Astrophysics Data System (ADS)

    Erdogan, Gizem; Ross, Arun

    2013-05-01

    Recent research in iris recognition has established the impact of non-cosmetic soft contact lenses on the recognition performance of iris matchers. Researchers in Notre Dame demonstrated an increase in False Reject Rate (FRR) when an iris without a contact lens was compared against the same iris with a transparent soft contact lens. Detecting the presence of a contact lens in ocular images can, therefore, be beneficial to iris recognition systems. This study proposes a method to automatically detect the presence of non-cosmetic soft contact lenses in ocular images of the eye acquired in the Near Infrared (NIR) spectrum. While cosmetic lenses are more easily discernible, the problem of detecting non-cosmetic lenses is substantially difficult and poses a significant challenge to iris researchers. In this work, the lens boundary is detected by traversing a small annular region in the vicinity of the outer boundary of the segmented iris and locating candidate points corresponding to the lens perimeter. Candidate points are identified by examining intensity profiles in the radial direction within the annular region. The proposed detection method is evaluated on two databases: ICE 2005 and MBGC Iris. In the ICE 2005 database, a correct lens detection rate of 72% is achieved with an overall classification accuracy of 76%. In the MBGC Iris database, a correct lens detection rate of 70% is obtained with an overall classification accuracy of 66:8%. To the best of our knowledge, this is one of the earliest work attempting to detect the presence of non-cosmetic soft contact lenses in NIR ocular images. The results of this research suggest the possibility of detecting soft contact lenses in ocular images but highlight the need for further research in this area.

  2. Design and fabrication of a microstructured bifocal intraocular lens

    NASA Astrophysics Data System (ADS)

    Stork, Wilhelm; Wagner, Armin; Kreiner, Christine F.; Mueller-Glaser, Klaus-Dieter

    1999-06-01

    Intraocular lenses IOLs allow the vision restoration of cataract patients. However the ability of accommodation is lost after cataract surgery. Multifocal lenses show two or more foci with different refractive powers. Far and near objects can be at focus simultaneously. No additional spectacles are necessary. Bifocal lenses can be fabricated as multizone or as diffractive lenses. Diffractive multifocal lenses show in contrast to multi zone multifocal lenses no change of the brightness ratio for the far and near focus with change of the pupil diameter. Diffractive lenses show a saw tooth like microscopic shape with a geometrical height of the teeth in the order of microns. The lens was fabricated with a mold technique in a flexible silicone material. The molds have been lathed in metal with a ultra precision diamond lathe machine. For the test of the optical performance a MTF-measurement machine was constructed for multifocal lenses. With this machine the imaging quality and the intensity ratio of the two foci were measured. The optical quality of the lens turned out to be diffraction limited. At the University Hospital of Giessen, Germany a first clinical evaluation with 23 patients has been performed and proved for the high quality of the manufactured IOLs.

  3. Contact Lenses Wettability In Vitro: Effect of Surface-Active Ingredients

    PubMed Central

    Lin, Meng C.; Svitova, Tatyana F.

    2010-01-01

    Purpose To investigate the release of surface-active agents (surfactants) from unworn soft contact lenses and their influence on the lens surface wettability in vitro. Methods Surface tension (ST) of blister pack solutions was measured by pendant-drop technique. STs at the air-aqueous interface and contact angles (CAs) of four conventional and seven silicone hydrogel (SiH) soft contact lenses (SCLs) were evaluated in a dynamic-cycling regime using a modified captive-bubble tensiometer-goniometer. Measurements were performed immediately after removal from blister packs, and after soaking in a glass vial filled with a surfactant-free solution, which was replaced daily for one week. Lens surface wettability was expressed as adhesion energy (AE) according to Young’s equation. Results STs of all blister pack solutions were lower than the reference ST of pure water (72.5 mN/m), indicating the presence of surfactants. When lenses were depleted of surfactants by soaking, the STs of all studied lenses and advancing CAs of selected lenses increased (p < 0.001). Receding CAs of all studied lenses were 12° ± 5° and were not affected by the presence of surfactants. For most of the conventional lenses, the surface wettability was largely dependent on surfactants, and reduced significantly after surfactant depletion. In contrast, most SiH lenses exhibited stable and self-sustained surface wettability in vitro. Conclusions The manufacturer-added surfactants affected wetting properties of all studied SCLs, although to different degrees. PMID:20400924

  4. Effect of blinking on the level of oxygen beneath hard and soft gas-permeable contact lenses.

    PubMed

    Efron, N; Carney, L G

    1983-03-01

    The oxygen tension, which can also be stated as the equivalent oxygen percentage (EOP), was measured beneath a variety of hard and soft gas-permeable contact lenses following static and dynamic wearing conditions. The significant increases in EOP beneath rigid lenses upon blinking were to be expected in view of the tear pumping mechanisms known to exist with such lenses. However, blinking was found to have a minimal effect on the EOP beneath hydrogen lenses, confirming earlier predictions.

  5. Nonmechanical bifocal zoom telescope.

    PubMed

    Valley, Pouria; Reza Dodge, Mohammad; Schwiegerling, Jim; Peyman, Gholam; Peyghambarian, N

    2010-08-01

    We report on a novel zoom lens with no moving parts in the form of a switchable Galilean telescope. This zoom telescope consists of two flat liquid-crystal diffractive lenses with apertures of 10mm that can each take on the focal lengths of -50 and +100cm, with a spacing of 50cm and, hence, a zoom ratio of 4x. The lenses are driven using a low-voltage ac source with 1.6V and exhibit millisecond switching times. The spectral characteristic of this diffractive zoom system is evaluated for light sources of various bandwidths. Potential applications for this technology include a zoom lens with no moving parts for camera phones and medical imaging devices.

  6. Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone-hydrogel contact lenses.

    PubMed

    Jung, Hyun Jung; Abou-Jaoude, Michelle; Carbia, Blanca E; Plummer, Caryn; Chauhan, Anuj

    2013-01-10

    Glaucoma is the second major cause of blindness in the world after cataract. Glaucoma management through eye drops that reduce the intraocular pressure (IOP) has major deficiencies including low patient compliance and low bioavailability. Extended wear contact lenses that deliver glaucoma drugs for extended periods could increase patient compliance, while also increasing the bioavailability. To develop extended wear contact lenses that can also provide extended glaucoma therapy, we disperse nanoparticles of PGT (propoxylated glyceryl triacylate) that contain a glaucoma drug timolol. The particles can also be loaded into prefabricated lenses by soaking the lenses in a solution of particles in ethanol. The particle loaded gels can release timolol in phosphate buffered saline (PBS) for about a month at room temperature. The most likely rate controlling mechanism is hydrolysis of the ester bond that links timolol to the PGT matrix, but other mechanisms such as water and drug diffusion, drug dissolution, drug-polymer chain cleavage, time-dependent drug permeability within the polymeric matrix, etc. may also be important. Nanoparticle incorporation in the silicone hydrogels results in reduction in ion and oxygen permeabilities, and an increase in modulus, and the impact on each of these properties is proportional to the particle loading. A gel with 5% particle loading can deliver timolol at therapeutic doses for about a month at room temperature, with a minimal impact on critical lens properties. Preliminary animal studies in Beagle dogs conducted with lenses in which particles are loaded by soaking the lenses in ethanol show a reduction in IOP.

  7. Porous structure of Purevision versus Focus Night&Day and conventional hydrogel contact lenses.

    PubMed

    López-Alemany, Antonio; Compañ, Vicente; Refojo, Miguel F

    2002-01-01

    The surface and bulk structures of hydrogel contact lenses that contain siloxane moieties, Purevisiontrade mark (balafilcon A) and Focus(R)Night&Daytrade mark (lotrafilcon A), were investigated. Standard hydrogel lenses of low (Seequence(R)), medium (Acuvue(R)), and high water content (Precision UV(R)) were used as controls. All the lenses were dehydrated in a series of ethanol solutions of increased concentration, critical-point dried in CO(2), and sputter coated with gold/palladium before they were examined by scanning electron microscopy. Of all lenses examined, only the balafilcon lenses presented, in addition to the polymer network porosity characteristic of all hydrogels, a macroporous structure that was observed on the front and back surfaces, and in their bulk. The average diameter of the macropores appears to be much larger, from one to several orders of magnitude, than the network porosity of standard hydrogel lenses. The macropores might contribute to the gas and water permeability of these lenses, as well as to their mobility on the cornea.

  8. Spoilation and clinical performance of monthly vs. three monthly Group II disposable contact lenses.

    PubMed

    Jones, L; Franklin, V; Evans, K; Sariri, R; Tighe, B

    1996-01-01

    Twelve subjects were fitted with a high water content, nonionic contact lens (Pilkington Barnes-Hind "Precision UV"), which was either replaced every month for 3 months or worn for 3 consecutive months before replacement occurred. Visual quality, high and low contrast acuity, and comfort were unaltered with either replacement schedule, but overall satisfaction was significantly greater with the shorter replacement schedule (p = 0.04). Front surface wettability revealed a large amount of intersubject variability and was reduced at the 3-month visit with the longer replacement period lenses (p = 0.003). Visible deposits also increased with longer replacement times (p < 0.05). Laboratory-based analytical results showed that both gross lipid and gross extractable protein significantly increased in the 3-month lenses compared with the 1-month lenses, with 44% less lipid accumulation and 60% less protein deposition occurring with the shorter replacement time. The results support the replacement of high water content lenses on a monthly basis.

  9. Switchable liquid crystal contact lenses: dynamic vision for the ageing eye

    NASA Astrophysics Data System (ADS)

    Milton, Harry E.; Gleeson, Helen F.; Morgan, Philip B.; Goodby, John W.; Cowling, Stephen; Clamp, John H.

    2014-02-01

    The inability of the eye to focus on nearby objects, presbyopia, is suffered by ~100% of people over the age of 50. Liquid crystal (LC) spectacle lenses have shown great potential for correcting presbyopia. However, correcting presbyopia in contact lens users has proven elusive and existing commercial options suffer significant compromises in vision and comfort. We describe a novel contact lens that includes a liquid crystal element that offers to correct presbyopia without the compromises associated with other technologies. We fabricated variable focus lenses using a balanced optical system, providing the additional optical power presbyopes require for near vision (typically +1.00 D to +2.00 D). The system uses positive optical power from the two substrates and variable negative optical power from the LC layer to form a balanced optical system which, when unpowered, corrects distance vision. Upon voltage application, the liquid crystal layer decreases in refractive index, resulting in additional optical power in the system, offering correction equivalent to reading glasses. Our new technology is based on a traditional contact lens material which could be placed directly on the eye. The liquid crystal lens employed is well suited to the small optical areas associated with contact lenses. We compare several different LC materials and geometries which are suitable for our application, and discuss the influence of material and geometry on switching times, optical quality and operating voltage. Our contact lenses typically switch +/-2.00D in response to < 10 Vrms with response times of the order of a second.

  10. Controlled Release of Antibiotics From Vitamin E-Loaded Silicone-Hydrogel Contact Lenses.

    PubMed

    Paradiso, Patrizia; Serro, Ana Paula; Saramago, Benilde; Colaço, Rogério; Chauhan, Anuj

    2016-03-01

    Symptoms of bacterial and fungal keratitis are typically treated through the frequent application of antibiotic and antifungal eye drops. The high frequency of half hourly or hourly eye drop administration required to treat these indications is tedious and could reduce compliance. Here, we combine in vitro experiments with a mathematical model to develop therapeutic soft contact lenses to cure keratitis by extended release of suitable drugs. We specifically focus on increasing the release duration of levofloxacin and chlorhexidine from 1-DAY ACUVUE(®) TrueEye™ and ACUVUE OASYS(®) contact lenses by incorporating vitamin E diffusion barriers. Results show that 20% of vitamin E loading in the contact lens increases the release duration of levofloxacin to 100 h and 50 h from 1-DAY ACUVUE(®) TrueEye™ and ACUVUE OASYS(®), respectively, which is a 3- and 6-fold increase, respectively, for the 2 lenses. For chlorhexidine, the increase is 2.5- and 10-fold, for the TrueEye™ and OASYS(®), respectively, to 130 h and 170 h. The mass of drug loaded in the lenses can be controlled to achieve a daily release comparable to the commonly prescribed eye drop therapy. The vitamin E-loaded lenses retain all critical properties for in vivo use.

  11. Comparing the Optical Properties of Soft Contact Lenses On and Off the Eye

    PubMed Central

    Kollbaum, Pete S.; Bradley, Arthur; Thibos, Larry N.

    2014-01-01

    Purpose The purpose of the current study was to examine the on- and off-eye optical performance of two types of soft contact lenses (hydrogel and silicone hydrogel). Methods The monochromatic aberrations (lambda = 850 nm) of contact lenses were measured on-eye using a clinical Shack-Hartmann ocular aberrometer. Additionally, we used an off-eye single-pass contact lens aberrometer (lambda = 540 nm) in which the soft contact lens was placed within a wet cell. Comparison of the lower and higher order aberrations measured with these two methods required compensation for different wavelengths and knowledge of the refractive index of the contact lens materials. Results The measured on-eye sphere and spherical aberration values were generally similar to those measured off-eye and those specified by the lens manufacturers for both types of soft contact lenses. However, there were notable differences, especially for high plus-powered lenses, which typically exhibited lower sphere power on the eye than expected from the lens specifications and from the off-eye measured powers, both of which were almost identical. Longitudinal spherical aberration varied with lens power in the hydrogel lenses, as expected from geometrical optics theory. Longitudinal spherical aberration measurements on- and off-eye, however, deviated significantly from that expected of a thin lens with spherical surfaces due to surface asphericities. The difference between on- and off-eye optics can be modeled as a tear lens, or as relative lens thickness changes caused by lens flexure. Conclusions The results of the current study reveal that the major difference between the on-eye lens optics and the manufacturers’ specifications are not due to lens errors, but due to eye-lens interactions, which could be either lens flexure or a tear lens forming behind the soft contact lens. PMID:23969894

  12. Haemophilus influenzae adherent to contact lenses associated with production of acute ocular inflammation.

    PubMed Central

    Sankaridurg, P R; Willcox, M D; Sharma, S; Gopinathan, U; Janakiraman, D; Hickson, S; Vuppala, N; Sweeney, D F; Rao, G N; Holden, B A

    1996-01-01

    Ten episodes of adverse responses to contact lens wear, including contact lens-induced acute red eye (CLARE), in which Haemophilus influenzae was isolated from contact lenses and/or from one of the external ocular sites at the time of the event, are described. All episodes occurred in patients wearing disposable hydrogel lenses on a 6-night extended-wear schedule. Two of the patients had recurrent episodes. H. influenzae was usually isolated in large numbers, and other bacteria or fungi colonizing the contact lens or the external ocular surface were usually present in low numbers. Those patients who were colonized with H. influenzae were more than 100 times as likely to have had a CLARE or infiltrative response than those subjects who were not colonized with this bacterium. H. influenzae colonization of the contact lens and eye may be subsequent to colonization of the nasopharynx because four of the seven patients presented with fever at the time of the event, with concurrent upper respiratory tract infection. Contact lens wearers should be made aware of the potential risk of CLARE associated with the wearing of contact lenses for extended periods during and subsequent to upper respiratory tract infection. PMID:8880493

  13. Calculating areal average thickness of rigid gas-permeable contact lenses.

    PubMed

    Weissman, B A

    1986-11-01

    A method to calculate areal average thickness of rigid contact lenses is shown. The method involves division of lens volume, which is determined from lens design specifications or derived from measured lens weight, by the area of the lens back surface. Areal average thickness may then be used with known oxygen permeability to generate oxygen transmissibility values.

  14. Proteomic analysis of protein deposits on worn daily wear silicone hydrogel contact lenses

    PubMed Central

    Wei, Xiaojia; Aliwarga, Yulina; Carnt, Nicole A.; Garrett, Qian; Willcox, Mark D.P.

    2008-01-01

    Purpose Previous studies have demonstrated deposition of tear proteins onto worn contact lenses. In this study, we used proteomic techniques to analyze the protein deposits extracted from worn daily wear silicone hydrogel contact lenses in combination with different lens care solutions. Methods Worn lenses were collected and protein deposits extracted using urea and surfactant. Protein extracts were desalted, concentrated, and then separated using one-dimensional gel electrophoresis. Individual protein components in extracts were identified using liquid chromatography combined with tandem mass spectrometry (LC-MS-MS) after trypsin digestion. Results One-dimensional gel electrophoresis revealed that lysozyme and other small proteins (around 20 kDa) were the most abundant proteins in the extracts. LC-MS-MS revealed a wide array of proteins in lens extracts with lysozyme and lipocalin 1 being the most commonly identified in deposit extracts. Conclusions Worn contact lenses deposit a wide array of proteins from tear film and other sources. Protein deposit profiles varied and were specific for each contact lens material. PMID:18989384

  15. Surface chemical structure for soft contact lenses as a function of polymer processing.

    PubMed

    Grobe, G L; Valint, P L; Ammon, D M

    1996-09-01

    The surface chemistry and topography of cast-molded Etafilcon-A and doubled-sided lathed Etafilcon-A soft contact lenses were determined to be significantly different. The variations in surface chemical and morphologic structure between the two lenses were the result of contact lens manufacturing methods. The surface of the cast-molded Etafilcon-A had a consistently less rough surface compared to the doubled sided lathed Etafilcon-A as determined by atomic force microscopy. The surface of the doubled sided lathed Etafilcon-A contained primarily silicone and wax contamination in addition to minute amounts of HEMA. The cast-molded Etafilcon-A had an elemental and chemical content which was consistent with the polymer stoichiometry. Contact angle wettability profiles revealed inherent wettability differences between the two lenses types. The cast-molded Etafilcon-A had an inherently greater water wettability, polarity, and critical surface tension. This means that these two lenses cannot be compared as similar or identical lens materials in terms of surface composition. The manufacturing method used to produce a soft contact lens directly determines the surface elemental and chemical structure as well as the morphology of the finished lens material. These results suggest possible differences in the clinical comfort, spoilage, and lubricity felt during patient wear.

  16. New design concepts for permeable rigid contact lenses.

    PubMed

    Williams, C E

    1979-03-01

    Gas permeable rigid lens materials offer the opportunity to reevaluate contact lens design. This paper presents the rationale and procedures followed in the development of a design concept for the Polycon lens material.

  17. A Long Term Study of the Water Content Changes in Three Types of Hydrogel Contact Lenses.

    DTIC Science & Technology

    1987-05-01

    in visual acuity , keratometric readings, and post-lens removal refractions? Appropriate statistical analysis of the data would be used to determine the...study. Visual acuities had to be correctable to 20/20 or better in each eye by both spectacles and contact lens. Participation in this study required...eye. This was done before and after lens removal. 4. Distant Snellen visual acuity --measured through contact lenses with a • -: Meanco projector and an

  18. Do thinner rigid gas permeable contact lenses provide superior initial comfort?

    PubMed

    Cornish, R; Sulaiman, S

    1996-03-01

    To test the hypothesis that thinner rigid gas permeable (RGP) contact lenses provide superior initial comfort, RGP lenses of 3 center thicknesses, 0.08, 0.12, and 0.16 mm, in otherwise matched parameters, were worn for 30 min by 17 unadapted subjects in a controlled, double masked, randomized study. Comfort ratings (0 to 100) after 30 min of wear were 42 +/- 30, 55 +/- 27, and 57 +/- 28 for the 0.08-, 0.12-, and 0.16-mm thick lenses, respectively (p = 0.04, multiple analysis of variance (MANOVA)), and 93 +/- 13 for the hydrogel control lens. The thinnest RGP lens was significantly less comfortable than its thicker counterparts (p = 0.03, Univariate F-test). There were no differences among the test lenses in edge shape, front surface wettability, or static lens fittings, and small differences in movement, vertical decentration, and front surface geometry were not significantly related to comfort. We hypothesize that the greater flexibility of the thinnest lens resulted in greater deformation of the lens during a blink cycle, causing transient peripheral lens lifting and interaction with the upper eyelid, thereby reducing comfort. In conclusion we found that thinner RGP lenses do not provide an initial comfort advantage and that very thin and, as a corollary, very flexible, RGP lenses can actually be less comfortable initially than stiffer, but otherwise matched, designs.

  19. Scanning electron microscopy, X-ray microanalysis and immunohistochemistry on worn soft contact lenses

    SciTech Connect

    Versura, P.; Maltarello, M.C.; Roomans, G.M.; Caramazza, R.; Laschi, R.

    1988-03-01

    The deposits accumulated on the surfaces of soft contact lenses are a cause of problems for the wearer of these lenses, as the deposits are never completely removed by the available washing solutions. Therefore it appears of interest to investigate the composition of these deposits. In this paper we review the major findings in the literature and, in addition, present our personal experience. We have studied new, continuously and daily worn soft contact lenses by scanning electron microscopy (SEM), X-ray microanalysis and immunohistochemistry. We have carefully evaluated preparative methods, and we can conclude that SEM and X-ray microanalysis are best carried out on unfixed, air-dried lenses. The deposits present consist mainly of mucus, especially on the tarsal side of the lenses. Chloride and potassium, coming from the tear fluid, as well as sulfur, derived from proteins, were found. Calcium was very rarely detected. IgG, IgA, IgE and C3c complement fractions were found only on the outer surfaces and not within the lens. We believe that the best characterization of the deposits is achieved by means of correlative techniques on the same lens. In fact, this approach integrates morphology and composition.

  20. Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release

    PubMed Central

    2015-01-01

    Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soaked lenses result in drug loss due to elution from the lenses. Here we present a nanodiamond (ND)-embedded contact lens capable of lysozyme-triggered release of TM for sustained therapy. We find that ND-embedded lenses composed of enzyme-cleavable polymers allow for controlled and sustained release of TM in the presence of lysozyme. Retention of drug activity is verified in primary human trabecular meshwork cells. These results demonstrate the translational potential of an ND-embedded lens capable of drug sequestration and enzyme activation. PMID:24506583

  1. In vitro and in vivo evaluation of ketotifen fumarate-loaded silicone hydrogel contact lenses for ocular drug delivery.

    PubMed

    Xu, Jinku; Li, Xinsong; Sun, Fuqian

    2011-02-01

    The purpose of this work was to evaluate the usefulness of silicone hydrogel contact lenses loaded with ketotifen fumarate for ocular drug delivery. First, silicone contact lenses were prepared by photopolymerization of bitelechelic methacrylated polydimethylsiloxanes macromonomer, 3-methacryloxypropyltris(trimethylsiloxy)silane, and N,N-dimethylacrylamide using ethylene glycol dimethacrylate as a cross-linker and Darocur 1173 as an initiator followed by surface plasma treatment. Then, the silicone hydrogel matrices of the contact lenses were characterized by equilibrium swelling ratio (ESR), tensile tests, ion permeability, and surface contact angle. Finally, the contact lenses were loaded with ketotifen fumarate by pre-soaking in drug solution to evaluate drug loading capacity, in vitro and in vivo release behavior of the silicone contact lenses. The results showed that ESR and ion permeability increase, and the surface contact angle and tensile strength decreased with the increase of DMA component in the silicone hydrogel. The drug loading and in vitro releases were dependent on the hydrogel composition of hydrophilic/hydrophobic phase of the contact lenses. In rabbit eyes, the pre-soaked contact lenses sustained ketotifen fumarate release for more than 24 h, which leads to a more stable drug concentration and a longer mean retention time in tear fluid than that of eye drops of 0.05%.

  2. The use of contact lenses during water-polo play: a 20-year study of Japanese college players.

    PubMed

    Komori, Yasuka; Kobayashi, Daisuke; Murase, Yosuke; Enomoto, Itaru; Takagi, Hideki; Kono, Ichiro

    2013-01-01

    This study investigated the extent of contact-lens use in Japanese college water-polo male players over 20 years (1991-2011, once every five years). Information about the use of contact lenses during play and the types of contact lens was obtained through a self-report questionnaire. The proportion of contact lens use among the players while playing water polo differed from 1991 to 2011 (χ2(4) = 25.28, P < 0.001, Cohen's d = 0.63). Fifty-four per cent of the players used contact lenses while playing in 1991 (P < 0.001); more than 74% in 1996; 89% in 2001; 84% in 2006; and 86% in 2011. While 96% of the contact lenses used by the players in 1991 were the soft type, 74%, 92%, 86%, and 88% of the contact lenses used in 1996, 2001, 2006, and 2011, respectively, were the disposable type. These findings indicated a high percentage of players were using contact lenses while playing water polo between 1996 and 2011. This could be because the majority of players used disposable lenses. The results suggest that increasing use of contact lenses by water-polo players is beneficial.

  3. Aspherical lens design using hybrid neural-genetic algorithm of contact lenses.

    PubMed

    Yen, Chih-Ta; Ye, Jhe-Wen

    2015-10-01

    The design of complex contact lenses involves numerous uncertain variables. How to help an optical designer to first design the optimal contact lens to reduce discomfort when wearing a pair of glasses is an essential design concern. This study examined the impact of aberrations on contact lenses to optimize a contact lens design for myopic and astigmatic eyes. In general, two aspherical surfaces can be assembled in an optical system to reduce the overall volume size. However, this design reduces the spherical aberration (SA) values at wide contact radii. The proposed optimization algorithm with optical design can be corrected to improve the SA value and, thus, reduce coma aberration (TCO) values and enhance the modulation transfer function (MTF). This means integrating a modified genetic algorithm (GA) with a neural network (NN) to optimize multiple-quality characteristics, namely the SA, TCO, and MTF, of contact lenses. When the proposed optional weight NN-GA is implemented, the weight values of the fitness function can be varied to adjust system performance. The method simplifies the selection of parameters in the optimization of optical systems. Compared with the traditional CODE V built-in optimal scheme, the proposed scheme is more flexible and intuitive to improve SA, TCO, and MTF values by 50.03%, 45.78%, and 24.7%, respectively.

  4. IMPACT OF A RINSE STEP ON PROTEIN REMOVAL FROM SILICONE HYDROGEL CONTACT LENSES

    PubMed Central

    Pucker, Andrew D.; Nichols, Jason J.

    2010-01-01

    PURPOSE To determine the impact of the rinse step in “no rub” contact lens care systems relative to its ability to assist in removing loosely associated and bound tear film proteins from a worn silicone hydrogel lens. METHODS After informed consent, subjects were fitted with lotrafilcon B contact lenses (CIBA Vision, Inc). If the fit was acceptable, subjects were asked to wear the lenses on a daily wear basis for 5 (+2, −0) days for an outcome visit. Subjects were instructed to use AQuify Multi-Purpose Disinfecting Solution (CIBA Vision, Inc) following the manufacturer's “no rub” instructions. At the outcome visit, contact lenses were then collected by a gloved examiner, with a sterile metal forceps, who rinsed the right lens but did not rinse the left lens upon removal from the eyes. Protein was extracted with a 50:50 0.2% trifluoroacetic acid-acetonitrile solution and quantified using a Bradford analyses. RESULTS Twenty contact lens wearers were enrolled in this study. For the non-rinsed lenses, the first extraction yielded 13.4 ± 9.2 µg/lens of protein, while the second extraction yielded 5.8 ± 2.8 µg/lens of protein. For the rinsed lenses, first extraction yielded an average of 3.0 ± 1.9 µg/lens of protein, while the second extraction yielded an average of 4.0 ± 2.3 µg/lens. Repeated measures ANOVA showed a significant interaction (F-statistic = 18.9, p< 0.0001) between the rinse of a lens and extraction number. CONCLUSIONS Rinsing a contact lens following removal from the eye removes well over one-half of the protein associated with it. Further, in order to biochemically recover all protein from a silicone hydrogel lens, it may be important to perform more than one chemical extraction from it. PMID:19609231

  5. Varifocal contact lenses for the correction of presbyopia.

    PubMed

    Port, M; Refson, K; Minards, J

    1995-09-01

    A Nissel +1.75 D PS45 lens' label power seems to be made up of about +0.75 D distance and +0.75 D near addition. There are individual variations which will depend on pupil size, corneal shape, lens position and ocular aberrations. When a +0.75 Bausch & Lomb U3 lens was used as a control, there was also a significant increase in 'accommodation' measured (+0.75 D), but this could not be explained. When two other lenses with an aspheric surface were studied, they also showed a near addition effect. In this supplementary study the changes were explained by changes in spectacle accommodation. A lens with two spherical surfaces did not show the expected increase in spectacle accommodation. Astigmatism, as a general rule, was not corrected by the PS45 lens, although the very occasional case did show some reduction. Visual acuity and contrast sensitivity at 8 cpd and 3 cpd were not significantly affected when compared to the control lens.

  6. Influence of power changes in single cut rigid contact lenses on tear pump efficiency.

    PubMed

    Fink, B A; Carney, L G; Hill, R M

    1992-09-01

    Differences between corneal oxygen uptake rates measured after 5 min of static (without blinking) and 5 min of dynamic (with blinking once every 5 s) non-gas permeable (polymethyl methacrylate) contact lens wear, referenced to the oxygen uptake rates of the normal open eye, were used as indications of tear pump efficiencies associated with each of seven contact lens back vertex powers (-9.00 to +9.00 D, in 3.00 D steps). Measurements were made in vivo on six human corneas showing with-the-rule (0.25 to 0.87 D) toricity. Lens overall diameter was 8.8 mm, optic zone diameter was 7.4 mm, and base curve radius was fitted "on K." Lens center thickness was 0.14 mm for all minus-powered lenses, and 0.19, 0.26, 0.34, and 0.41 mm for the plano, +3.00, +6.00, and +9.00 D lenses, respectively, maintaining an edge thickness of 0.11 mm. Under both static and dynamic wearing conditions, no significant differences were found among the corneal oxygen uptake rates associated with the various contact lens back vertex powers; however, the difference between the static and dynamic condition data, an indication of tear pump efficiency, was greatest for the -3.00 D lens. The difference values associated with the +9.00 and +6.00 D lenses were significantly lower than those associated with the minus power lenses.

  7. [Ophthalmophysiological features of applying soft contact lenses to correct myopia in pilots].

    PubMed

    Ovechkin, I G; Rosliakov, V A; Aleksandrova, L A

    1997-01-01

    The development of effective methods for preventing and correcting myopia in pilots is one of the most important problems of aeronautic ophthalmology. The majority of Russian and foreign aeronautic ophthalmologists agree that contact correction is the principal method for repair of occupational vision of myopic pilots. Experiments with soft contact lenses with 38 and 70% humor content were carried out. The methodology was based on comprehensive examinations of the vision status and status of the organ of vision under common conditions on the Earth and during simulation of unfavorable flight factors. The results indicate that contact lenses are a safe means for correcting myopia in pilots. This is confirmed by the absence of unfavorable changes in the main visual functions and in the status of the anterior segment of the eye, by a constant level of visual working capacity, and by the absence of negative subjective sensations.

  8. Tolerance to systemic isotretinoin therapy in two patients using highly wettable contact lenses.

    PubMed

    Arman, Ayşegül; Demirseren, D Deniz; Akoglu, Gulsen

    2014-01-01

    Purpose. Numerous ocular side effects have been reported with the use of systemic isotretinoin therapy. Herein, we presented two contact lens user patients who did not have contact lens intolerance during systemic isotretinoin therapy. Methods. 25-year-old male and 20-year-old female patients with severe acne vulgaris who were using highly wettable silicone hydrogel contact lenses which increase tear film stability were examined. Tear film function tests including Schirmer tests and tear break up time (TBUT) test and ocular surface staining with fluorescein were done. Subjective ocular complaints were scored with ocular surface disease index (OSDI) questionnaire. Patients were followed up monthly and examinations were repeated at each visit. Results. Both patients completed the therapy after a cumulative dose of 140 mg/kg isotretinoin in 6 months. The OSDI score and tear film function tests before and after treatment were all within normal limits. Discussion. Highly wettable contact lenses that provide increase in the tear film stability may be used during systemic retinoid therapy under close followups. Although isotretinoin affects ocular glands, the differences between tolerances to this retinoid therapy need to be investigated in larger patient groups using contact lenses.

  9. Tolerance to Systemic Isotretinoin Therapy in Two Patients Using Highly Wettable Contact Lenses

    PubMed Central

    Arman, Ayşegül; Demirseren, D. Deniz

    2014-01-01

    Purpose. Numerous ocular side effects have been reported with the use of systemic isotretinoin therapy. Herein, we presented two contact lens user patients who did not have contact lens intolerance during systemic isotretinoin therapy. Methods. 25-year-old male and 20-year-old female patients with severe acne vulgaris who were using highly wettable silicone hydrogel contact lenses which increase tear film stability were examined. Tear film function tests including Schirmer tests and tear break up time (TBUT) test and ocular surface staining with fluorescein were done. Subjective ocular complaints were scored with ocular surface disease index (OSDI) questionnaire. Patients were followed up monthly and examinations were repeated at each visit. Results. Both patients completed the therapy after a cumulative dose of 140 mg/kg isotretinoin in 6 months. The OSDI score and tear film function tests before and after treatment were all within normal limits. Discussion. Highly wettable contact lenses that provide increase in the tear film stability may be used during systemic retinoid therapy under close followups. Although isotretinoin affects ocular glands, the differences between tolerances to this retinoid therapy need to be investigated in larger patient groups using contact lenses. PMID:24707422

  10. Cultivation of Human Oral Mucosal Explants on Contact Lenses.

    PubMed

    Zsebik, Barbara; Ujlaky-Nagy, László; Losonczy, Gergely; Vereb, György; Takács, Lili

    2017-03-24

    Purpose/Aim: Autologous cultivated oral mucosal (OM) epithelial transplantation has been successfully used as corneal epithelial replacement in bilateral limbal stem cell deficiency. Recently, lotrafilcon A contact lens (CL) surface was described as a suitable carrier for cultured stem cells in corneal epithelial transplantation. Our aim was to establish explant cultures from human OM on CL carriers that are free of animal-derived materials and feeder cells.

  11. Attachment of Pseudomonas to human-worn, disposable etafilcon A contact lenses.

    PubMed

    Boles, S F; Refojo, M F; Leong, F L

    1992-01-01

    After 7 days of continuous wear, Acuvue (Vistakon, Jacksonville, FL, U.S.A.; etafilcon A) lenses were soaked in a Pseudomonas aeruginosa suspension (1.4 x 10(8) cfu/ml). New Acuvue lenses served as controls. A single strain of P aeruginosa harvested from a human corneal ulcer was used throughout the experiment. Lenses were examined by culture and scanning electron microscopy (SEM). We found significantly greater (p less than 0.05) bacterial attachment to new Acuvue lenses [culture, 3.1 x 10(4) (+/- 0.82 x 10(4)) cfu/mm2; SEM, 2.6 x 10(4) (+/- 0.47 x 10(4)) bacteria/mm2] compared with those previously worn [culture, 1.0 x 10(4) (+/- 0.17 x 10(4)) cfu/mm2; SEM, 0.73 x 10(4) (+/- 0.21 x 10(4)) bacteria/mm2]. No statistical difference was found among the individuals. Our findings demonstrate that the biological coating resulting from 1 week of continuous contact lens wear restricts P. aeruginosa attachment to the Acuvue lens when comparing new and used lenses.

  12. Rigid gas-permeable vs. hydrogel contact lenses for extended wear.

    PubMed

    Fonn, D; Holden, B A

    1988-07-01

    A clinical trial was conducted to compare the extended wear performance of rigid gas-permeable (RGP) contact lenses with that of soft lenses. Subjects were fitted with a RGP lens (Boston IV) in one eye and a soft lens (Bausch & Lomb "O" series) in the other eye, and wore them on an extended wear basis for up to 3 months. No subjects developed any acute adverse reactions in the RGP lens-wearing eye. After the initial adaptation period, subject acceptance of RGP extended wear in terms of vision and comfort was superior. The RGP lenses also induced less chronic hypoxic stress than hydrogel lenses of comparable Dk/L, as evidenced by the presence of epithelial microcysts. Several complications of RGP extended wear were observed including lens binding, blepharoptosis, transient pupil size increases, and corneal staining. As hypoxia-induced corneal changes, such as microcysts and striae, were observed in the RGP lens-wearing eyes, we consider that these particular RGP lenses do not have adequate oxygen transmissibility for successful long-term extended wear. However, if RGP lens materials of higher oxygen transmissibility and better designs can be attained, the potential of RGP extended wear would appear promising.

  13. Pathogenic Free-Living Amoebae Isolated From Contact Lenses of Keratitis Patients

    PubMed Central

    HAJIALILO, Elham; NIYYATI, Maryam; SOLAYMANI, Mohammad; REZAEIAN, Mostafa

    2015-01-01

    Background: Free-living amoeba (FLA)-related keratitis is a progressive infection of the cornea with poor prognosis. The present study aimed to investigates the contact lenses of patients with keratitis for pathogenic free-living amoebae. Methods: Overall, 62 contact lenses and their paraphernalia of patients with keratitis cultured and tested for the presence of free-living amoebae using morphological criteria. Unusual plates including plates containing mix amoebae and Vermamoeba were submitted to molecular analysis. Results: Out of 62 plates, 11 revealed the outgrowth of free living amoeba of which 9 were Acanthamoeba, one plates contained mix amoebae including Acanthamoeba and Vermamoeba and one showed the presence of Vermamoeba. These two latter plates belonged to patients suffered from unilateral keratitis due to the misused of soft contact lenses. One of the patients had mix infection of Acanthamoeba (T4) and V. vermiformis meanwhile the other patient was infected with the V. vermiformis. Conclusion: Amoebic keratitis continues to rise in Iran and worldwide. To date, various genera of free-living amoebae such as Vermamoeba could be the causative agent of keratitis. Soft contact lens wearers are the most affected patients in the country, thus awareness of high-risk people for preventing free-living amoebae related keratitis is of utmost importance. PMID:26811719

  14. Composition of incubation solution impacts in vitro protein uptake to silicone hydrogel contact lenses

    PubMed Central

    Heynen, Miriam; Luensmann, Doerte; Jones, Lyndon

    2012-01-01

    Purpose To determine the impact of incubation solution composition on protein deposition to silicone hydrogel (SH) contact lenses using a simplistic and a complex model of the tear film. Methods Three SH materials – senofilcon A (SA), lotrafilcon B (LB), and balafilcon A (BA) – were incubated in two different solutions; Solution A was a simplistic augmented buffered saline solution containing a single protein, whereas Solution B was a complex artificial tear solution (ATS), containing the augmented buffered saline solution in addition to proteins, lipids, and mucins (pH=7.4). The proteins of interest (lysozyme, lactoferrin, albumin) were radiolabeled with Iodine-125 (2% protein of interest) and the accumulation of the conjugated protein to the lens materials was determined after 1, 7, 14, and 28 days of incubation. Protein deposition was measured using a gamma counter and the raw data were translated into absolute amounts (µg/lens) via extrapolation from standards. Results After 28 days, lysozyme uptake was significantly lower on BA lenses when incubated in Solution A (33.7 μg) compared to Solution B (56.2 μg), p<0.001. SA lenses deposited similar amounts of lysozyme when incubated in either Solution A (2.6 μg) or Solution B (4.1 μg), p>0.05. LB lenses also deposited similar amounts of lysozyme for both solutions (Solution A: 5.0 μg, Solution B: 4.7 μg, p>0.05). After 28 days, BA lenses accumulated approximately twice the amount of lactoferrin than the other lens materials, with 30.3 μg depositing when exposed to Solution A and 22.0 μg with Solution B. The difference between the two solutions was statistically significant (p<0.001). LB materials deposited significantly greater amounts of lactoferrin when incubated in Solution A (16.6 μg) compared to Solution B (10.3 μg), p<0.001. Similar amounts of lactoferrin were accumulated onto SA lenses regardless of incubation solution composition (Solution A: 8.2 μg, Solution B: 11.2 μg, p>0.05). After 28

  15. Atomic force microscopy and scanning electron microscopy analysis of daily disposable limbal ring contact lenses

    PubMed Central

    Lorenz, Kathrine Osborn; Kakkassery, Joseph; Boree, Danielle; Pinto, David

    2014-01-01

    Background Limbal ring (also known as ‘circle’) contact lenses are becoming increasingly popular, especially in Asian markets because of their eye-enhancing effects. The pigment particles that give the eye-enhancing effects of these lenses can be found on the front or back surface of the contact lens or ‘enclosed’ within the lens matrix. The purpose of this research was to evaluate the pigment location and surface roughness of seven types of ‘circle’ contact lenses. Methods Scanning electron microscopic (SEM) analysis was performed using a variable pressure Hitachi S3400N instrument to discern the placement of lens pigments. Atomic force microscopy (Dimension Icon AFM from Bruker Nano) was used to determine the surface roughness of the pigmented regions of the contact lenses. Atomic force microscopic analysis was performed in fluid phase under contact mode using a Sharp Nitride Lever probe (SNL-10) with a spring constant of 0.06 N/m. Root mean square (RMS) roughness values were analysed using a generalised linear mixed model with a log-normal distribution. Least square means and their corresponding 95% confidence intervals were estimated for each brand, location and pigment combination. Results SEM cross-sectional images at 500× and 2,000× magnification showed pigment on the surface of six of the seven lens types tested. The mean depth of pigment for 1-DAY ACUVUE DEFINE (1DAD) lenses was 8.1 μm below the surface of the lens, while the remaining lens types tested had pigment particles on the front or back surface. Results of the atomic force microscopic analysis indicated that 1DAD lenses had significantly lower root mean square roughness values in the pigmented area of the lens than the other lens types tested. Conclusions SEM and AFM analysis revealed pigment on the surface of the lens for all types tested with the exception of 1DAD. Further research is required to determine if the difference in pigment location influences on-eye performance. PMID

  16. [Acanthamoeba keratitis after use of soft contact lenses--case report].

    PubMed

    Ziak, P; Ondriska, F; Mrva, M

    2003-09-01

    The case history of a 39-year patient suffering from a deep inflammation of cornea and not responding to conventional antibiotic treatment is presented. The patient was using soft contact lenses during the period of initial symptoms; moreover, he was bathing in thermal bathing pool. A cultivation examination of smears from the area of corneal defect revealed the presence of Acanthamoeba lugdunensis in combination with bacterial infection by Pseudomonas aeruginosa. The available data indicate that it is the first case of acanthamoeba karatitis (AK) after the application of contact lenses in Slovakia. A long-term local treatment with propamidin isethionate (Brolene gtt, ung.) resulted in healing up. The subsequent vision after 16 months since the initial symptoms proved to be 6/12 (0.5). The healing of the centrally localized defect changed the curvature of cornea with consequent hypermetropic shift. The defect completely corrected the patient's myopia (-8.5). The paper describes present possibilities of AK therapy.

  17. Simulation contact lenses for AMD health state utility values in NICE appraisals: a different reality

    PubMed Central

    Butt, Thomas; Crossland, Michael D; West, Peter; Orr, Shepley W; Rubin, Gary S

    2015-01-01

    Background/aims The National Institute for Health and Care Excellence (NICE) has recommended the use of ranibizumab for neovascular age-related macular degeneration (AMD) and for diabetic macular oedema (DMO) as part of its health technology appraisal process. In the economic evaluations of both interventions, utility values were derived from members of the general public wearing contact lenses with a central opacity that was meant to simulate the blind spot experienced by many patients with advanced retinal disease. This paper tests the validity of the contact lens simulation, and finding it to be invalid, explores the impact on prior economic evaluations. Methods Visual acuity, contrast sensitivity and visual fields were assessed with and without simulation lenses in five healthy subjects with normal vision. Results We identified important differences between the contact lens simulation and vision loss experienced by patients with AMD. The contact lens simulator did not cause the central scotoma which is characteristic of late-stage AMD and which leads to severe difficulty with everyday activities such as reading or recognising faces and objects. The contact lens instead caused a reduction in retinal illumination experienced by the subjects as a general dimming across the retina. Conclusions A contact lens with a central opacity does not simulate a central scotoma. The clinical differences between simulated and actual AMD suggest there has been an underestimation of the severity of AMD health states. This brings into question the validity of the economic evaluations of treatments for AMD and DMO used by NICE. PMID:25351679

  18. The efficiency of contact lens care regimens on protein removal from hydrogel and silicone hydrogel lenses

    PubMed Central

    Heynen, Miriam; Liu, Lina; Sheardown, Heather; Jones, Lyndon

    2010-01-01

    Purpose To investigate the efficiency of lysozyme and albumin removal from silicone hydrogel and conventional contact lenses, using a polyhexamethylene biguanide multipurpose solution (MPS) in a soaking or rubbing/soaking application and a hydrogen peroxide system (H2O2). Methods Etafilcon A, lotrafilcon B and balafilcon A materials were incubated in protein solutions for up to 14 days. Lenses were either placed in radiolabeled protein to quantify the amount deposited or in fluorescent-conjugated protein to identify its location, using confocal laser scanning microscopy (CLSM). Lenses were either rinsed with PBS or soaked overnight in H2O2 or MPS with and without lens rubbing. Results After 14 days lysozyme was highest on etafilcon A (2,200 μg) >balafilcon A (50 µg) >lotrafilcon B (9.7 µg) and albumin was highest on balafilcon A (1.9 µg) =lotrafilcon B (1.8 µg) >etafilcon A (0.2 µg). Lysozyme removal was greatest for balafilcon A >etafilcon A >lotrafilcon B, with etafilcon A showing the most change in protein distribution. Albumin removal was highest from etafilcon A >balafilcon A >lotrafilcon B. H2O2 exhibited greater lysozyme removal from etafilcon A compared to both MPS procedures (p<0.001) but performed similarly for lotrafilcon B and balafilcon A lenses (p>0.62). Albumin removal was solely material specific, while all care regimens performed to a similar degree (p>0.69). Conclusions Protein removal efficiency for the regimens evaluated depended on the lens material and protein type. Overall, lens rubbing with MPS before soaking did not reduce the protein content on the lenses compared to nonrubbed lenses (p=0.89). PMID:20098668

  19. Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions.

    PubMed

    Sandri, Giuseppina; Bonferoni, Maria Cristina; Rossi, Silvia; Delfino, Alessio; Riva, Federica; Icaro Cornaglia, Antonia; Marrubini, Giorgio; Musitelli, Giorgio; Del Fante, Claudia; Perotti, Cesare; Caramella, Carla; Ferrari, Franca

    2016-07-25

    Hemoderivative tear substitutes contain various ephiteliotrophic factors, such as growth factors (GF), involved in ocular surface homeostasis without immunogenic properties. The aim of the present work was the loading of platelet lysate into contact lenses to improve the precorneal permanence of platelet lysate growth factors on the ocular surface to enhance the treatment of corneal lesions. To this purpose, chondroitin sulfate, a sulfated glycosaminoglycan, which is normally present in the extracellular matrix, was associated with platelet lysate. In fact, chondroitin sulfate is capable of electrostatic interaction with positively charged growth factors, in particular, with bFGF, IGF, VEGF, PDGF and TGF-β, resulting in their stabilization and reduced degradation in solution. In the present work, various types of commercially available contact lenses have been loaded with chondroitin sulfate or chondroitin sulfate in association with platelet lysate to achieve a release of growth factors directly onto the corneal surface lesions. One type of contact lenses (PureVision(®)) showed in vitro good proliferation properties towards corneal cells and were able to enhance cut closure in cornea constructs.

  20. Human IgA inhibits adherence of Acanthamoeba polyphaga to epithelial cells and contact lenses.

    PubMed

    Campos-Rodríguez, Rafael; Oliver-Aguillón, Gabriela; Vega-Pérez, Luz M; Jarillo-Luna, Adriana; Hernández-Martínez, Dolores; Rojas-Hernández, Saúl; Rodríguez-Monroy, Marco A; Rivera-Aguilar, Víctor; González-Robles, Arturo

    2004-09-01

    Specific anti-Acanthamoeba IgA antibodies have been detected in the serum and tears of patients and healthy individuals. However, the role of human secretory IgA antibodies in inhibiting the adherence of Acanthamoeba had not been previously investigated. Therefore, the purpose of this study was to purify secretory IgA from human colostrum and analyze its effect on the adherence of Acanthamoeba trophozoites to contact lenses and Madin-Darby canine kidney (MDCK) cells. IgA antibodies to Acanthamoeba polyphaga in colostrum of healthy women as well as in saliva and serum of healthy subjects were analyzed by ELISA and Western blot analysis. In serum, saliva, and colostrum, we detected IgA antibodies that recognized several antigens of A. polyphaga. In addition, colostrum and IgA antibodies purified from it inhibited adherence of A. polyphaga trophozoites to contact lenses and MDCK cells. These results suggest that IgA antibodies may participate in the resistance to the amoebic infection, probably by inhibiting the adherence of the trophozoites to contact lenses and corneal epithelial cells.

  1. Noninvasive Continuous Monitoring of Tear Glucose Using Glucose-Sensing Contact Lenses.

    PubMed

    Ascaso, Francisco J; Huerva, Valentín

    2016-04-01

    : The incidence of diabetes mellitus is dramatically increasing in the developed countries. Tight control of blood glucose concentration is crucial to diabetic patients to prevent microvascular complications. Self-monitoring of blood glucose is widely used for controlling blood glucose levels and usually performed by an invasive test using a portable glucometer. Many technologies have been developed over the past decades with the purpose of obtaining a continuous physiological glycemic monitoring. A contact lens is the ideal vehicle for continuous tear glucose monitoring of glucose concentration in tear film. There are several research groups that are working in the development of contact lenses with embedded biosensors for continuously and noninvasively monitoring tear glucose levels. Although numerous aspects must be improved, contact lens technology is one step closer to helping diabetic subjects better manage their condition, and these contact lenses will be able to measure the level of glucose in the wearer's tears and communicate the information to a mobile phone or computer. This article reviews studies on ocular glucose and its monitoring methods as well as the attempts to continuously monitor the concentration of tear glucose by using contact lens-based sensors.

  2. Cancellation of the boundary and edge effects by choice of lens thickness during oxygen permeability measurement of contact lenses.

    PubMed

    Weissman, B A; Fatt, I

    1989-05-01

    Edge and boundary effect correction factors have been proposed to modify the oxygen transmissibility and permeability values obtained by polarographic measurement of contact lenses. These two correction factors are opposite in sign: the boundary effect causes oxygen transmissibility and permeability to be underestimated; the edge effect causes the reverse. Two methods are used to define lens thickness values where the two effects should be quantitatively equal and therefore cancel for both rigid gas permeable and hydrogel contact lenses.

  3. Oxygen permeability of the pigmented material used in cosmetic daily disposable contact lenses

    PubMed Central

    Galas, Stephen; Copper, Lenora L

    2016-01-01

    Purpose To evaluate the individual contributions of pigment colorant and packing solution containing polyvinyl pyrrolidone (PVP) on the oxygen permeability (Dk) of a cosmetic printed etafilcon A daily disposable contact lens packaged with PVP. Method The oxygen transport of a contact lens is evaluated through the central optical zone of the lens. Cosmetic printed contact lenses contain pigment colorant in the periphery or mid-periphery of the lens. Therefore, to assess the impact of cosmetic print on oxygen permeability, special lenses need to be produced that contain the colorant within the central optical zone. This technique was used to obtain multiple measurements of nonedge-corrected Dk/t of both the center pigmented lens and its nonpigmented equivalent, using a polarographic measurement described in International Organization for Standardization (ISO) 18369-4:2006(E), and the Dk derived for each measurement is corrected for edge effect. In addition, the edge-corrected Dk values of lenses made from the same monomer batch were measured. The lenses were packaged and autoclaved with and without proprietary technology which embeds PVP in the contact lens during autoclaving. The resulting Dk value of the printed lens material was then used with thickness data to generate true Dk/t profiles for a given lens power. Results The edge-corrected Dk of the printed etafilcon A lens with offset pigment colorant was measured to be 19.7×10−11 (cm2/s) (mL O2/mL·mmHg) at 35°C. This was within ±20% tolerance range as specified in ISO 18369-2:2012(E) for the edge-corrected Dk of the nonpigmented etafilcon A control lens evaluated during the same session, 19.5×10−11 (cm2/s) (mL O2/mL·mmHg). The edge-corrected Dk values of the lenses packaged with PVP (mean 20.1, standard deviation [SD] 0.3) were also within the ±20% tolerance range compared to those packaged without PVP (mean 20.0, SD 0.3). Conclusion The pigment colorant and PVP embedded in the contact lens during

  4. Tear Oxygen Under Hydrogel and Silicone Hydrogel Contact Lenses in Humans

    PubMed Central

    Bonanno, Joseph A.; Clark, Christopher; Pruitt, John; Alvord, Larry

    2011-01-01

    Purpose To determine the tear oxygen tension under a variety of conventional and silicone hydrogel contact lenses in human subjects. Methods Three hydrogel and five silicone hydrogel lenses (Dk/t = 17 to 329) were coated on the back surface with an oxygen sensitive, bovine serum albumin-Pd meso-tetra (4-carboxyphenyl) porphine complex (BSA-porphine). Each lens type was placed on the right eye of 15 non-contact lens wearers to obtain a steady-state open eye tear oxygen tension using oxygen sensitive phosphorescence decay of BSA-porphine. A closed-eye oxygen tension estimate was obtained by measuring the change in tear oxygen tension after 5 min of eye closure. In separate experiments, a goggle was placed over the lens wearing eye and a gas mixture (PO2 = 51 torr) flowed over the lens to simulate anterior lens oxygen tension during eye closure. Results Mean open eye oxygen tension ranged from 58 to 133 torr. Closed eye estimates ranged from 11 to 42 torr. Oxygen tension under the goggle ranged from 8 to 48 torr and was higher than the closed eye estimate for six out of the eight lenses, suggesting that the average closed eye anterior lens surface oxygen tension is <51 torr. For Dk/t >30, the measured tear oxygen tension is significantly lower than that predicted from previous studies. Conclusions The phosphorescence decay methodology is capable of directly measuring the in vivo post lens PO2 of high Dk/t lenses without disturbing the contact lens or cornea. Our data indicate that increasing Dk/t up to and beyond 140 continues to yield increased flux into the central cornea. PMID:19609230

  5. Higher-Order Aberrations when wearing Sphere and Toric Soft Contact Lenses

    PubMed Central

    Berntsen, David A.; Merchea, Mohinder M.; Richdale, Kathryn; Mack, Carla J.; Barr, Joseph T.

    2009-01-01

    Purpose To determine the on-eye effect of spherical and toric contact lens design on higher-order aberrations (HOA). Methods Thirty eyes (15 subjects) entered a masked, randomized, cross-over study. Each eye was fitted with the spherical and toric lens of the following brands in random order: Acuvue Advance, Biomedics 55, Frequency 55, and SofLens 66. HOAs were measured using the Zywave II Aberrometer over a 6-mm aperture up to fifth order. A linear model accounting for the fixed effect of lens type and random effects of subject and eye was created. Paired t-tests were completed between lens brands within the spherical and toric lenses and between the spherical and toric lens within each brand. Best-corrected visual acuity (VA) was measured and compared. Results No clinically meaningful differences in total HOAs were found between brands or between the spherical and toric lens within a brand. Positive spherical aberration (SA) was reduced by all spherical and toric lenses compared to wearing no lens by 0.07 to 0.23 μm (p<0.0001). Frequency toric induced the greatest change in SA. The thin-zone design lens (Acuvue Advance for Astigmatism) had a statistically different amount of vertical coma (−0.04 μm) than the three prism-balast toric lenses (0.11 to 0.23 μm; p<0.0001). SofLens toric had the greatest amount of vertical coma, but better VA than Acuvue Advance for Astigmatism and Frequency toric. With the exception of Acuvue Advance for Astigmatism, toric lenses had greater absolute magnitude of vertical coma than their sphere counterparts (all p<0.002). No other significant HOA differences were observed. Conclusions Toric contact lenses with prism-ballast designs demonstrated more vertical coma, but better VA. Positive SA was reduced by spherical and toric contact lenses. The visual quality effect of lens design and material on induced HOAs warrants further investigation. PMID:19156015

  6. Surfactant-laden soft contact lenses for extended delivery of ophthalmic drugs.

    PubMed

    Kapoor, Yash; Thomas, Justin C; Tan, Grace; John, Vijay T; Chauhan, Anuj

    2009-02-01

    Eye drops are inefficient means of delivering ophthalmic drugs because of limited bioavailability and these can cause significant side effects due to systemic uptake of the drug. The bioavailability for ophthalmic drugs can be increased significantly by using contact lenses. This study focuses on the development of surfactant-laden poly-hydroxy ethyl methacrylate (p-HEMA) contact lenses that can release Cyclosporine A (CyA) at a controlled rate for extended periods of time. We focus on various Brij surfactants to investigate the effects of chain length and the presence of an unsaturated group on the drug release dynamics and partitioning inside the surfactant domains inside the gel. The gels were imaged by cryogenic scanning electron microscopy (cryo-SEM) to obtain direct evidence of the presence of surfactant aggregates in the gel, and to investigate the detailed microstructure for different surfactants. The images show a distribution of nano pores inside the surfactant-laden hydrogels which we speculate are regions of surfactant aggregates, possibly vesicles that have a high affinity for the hydrophobic drug molecule. The gels are further characterized by studying their mechanical and physical properties such as transparency, surface contact angle and equilibrium water content to determine their suitability as extended wear contact lenses. Results show that Brij surfactant-laden p-HEMA gels provide extended release of CyA, and possess suitable mechanical and optical properties for contact lens applications. The gels are not as effective for extended release of two other hydrophobic ophthalmic drugs, dexamethasone (DMS) and dexamethasone 21 acetate (DMSA) because of insufficient partitioning inside the surfactant aggregates.

  7. Evaluation of Sodium Hyaluronate Lubricating Drops Used before Insertion of Contact Lenses on Symptomatology, Severity, and Intensity of Ocular Dryness

    PubMed Central

    Michaud, Langis; Frenette, Benoît

    2012-01-01

    Purpose. This study aimed to evaluate outcomes from the use of a sodium hyaluronate (SH)-based comfort drop, instilled before the insertion of contact lenses, in a population of symptomatic contact lens wearers. Methods. This was a cross-over, open-label, multi-sites study. Subjects were fitted with silicone hydrogel lenses and followed for two months. Before insertion of the lenses, SH drops was instilled in the lens for half of the group. The other half did the same on the second month. Objectives and subjective outcomes were measured and compared before from baseline with the ones collected after usage of SH drops. PMID:24575306

  8. In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery.

    PubMed

    Maulvi, Furqan A; Lakdawala, Dhara H; Shaikh, Anjum A; Desai, Ankita R; Choksi, Harsh H; Vaidya, Rutvi J; Ranch, Ketan M; Koli, Akshay R; Vyas, Bhavin A; Shah, Dinesh O

    2016-03-28

    Glaucoma is commonly treated using eye drops, which is highly inefficient due to rapid clearance (low residence time) from ocular surface. Contact lenses are ideally suited for controlled drug delivery to cornea, but incorporation of any drug loaded particulate system (formulation) affect the optical and physical property of contact lenses. The objective of the present work was to implant timolol maleate (TM) loaded ethyl cellulose nanoparticle-laden ring in hydrogel contact lenses that could provide controlled drug delivery at therapeutic rates without compromising critical lens properties. TM-implant lenses were developed, by dispersing TM encapsulated ethyl cellulose nanoparticles in acrylate hydrogel (fabricated as ring implant) and implanted the same in hydrogel contact lenses (sandwich system). The TM-ethyl cellulose nanoparticles were prepared by double emulsion method at different ratios of TM to ethyl cellulose. The X-ray diffraction studies revealed the transformation of TM to amorphous state. In vitro release kinetic data showed sustained drug release within the therapeutic window for 168h (NP 1:3 batch) with 150μg loading. Cytotoxicity and ocular irritation study demonstrated the safety of TM-implant contact lenses. In vivo pharmacokinetic studies in rabbit tear fluid showed significant increase in mean residence time (MRT) and area under curve (AUC), with TM-implant contact lenses in comparison to eye drop therapy. In vivo pharmacodynamic data in rabbit model showed sustained reduction in intra ocular pressure for 192h. The study demonstrated the promising potential of implantation technology to treat glaucoma using contact lenses, and could serve as a platform for other ocular diseases.

  9. Assessment of ultraviolet B–blocking effects of weekly disposable contact lenses on corneal surface in a mouse model

    PubMed Central

    Lin, David Pei-Cheng; Chang, Han-Hsin; Yang, Li-Chien; Huang, Tzu-Ping; Liu, Hsiang-Jui; Chang, Lin-Song; Lin, Chien-Hsun

    2013-01-01

    Purpose Weekly disposable soft contact lenses have been widely used recently, but their shield effects against ultraviolet (UV) irradiation remain to be evaluated. This study investigated the bioprotective effects of several weekly soft contact lenses against UVB irradiation on the corneal surface in a mouse model. Methods Fifty ICR mice were randomly divided into five groups: (1) blank control, (2) exposed to UVB without contact lens protection, (3) exposed to UVB and protected with Vifilcon A contact lenses, (4) exposed to UVB and protected with Etafilcon A contact lenses, and (5) exposed to UVB and protected with HEMA+MA contact lenses. The exposure to UVB irradiation was performed at 0.72 J/cm2/day after anesthesia for a 7-day period, followed by cornea surface assessment for smoothness, opacity, and grading of lissamine green staining. Tissue sections were prepared for hematoxylin and eosin staining and immunohistochemical detection by using antibodies against myeloperoxidase, cytokeratin-5, P63, Ki-67, nuclear factor-kappa B (p65), cyclooxygenase-2, Fas L, and Fas. Results The results showed impaired corneal surface with myeloperoxidase+ polymorphonuclear leukocyte infiltration into the stroma after UVB exposure, in contrast to the intact status of the blank controls. The corneas with Etafilcon A and HEMA+MA contact lenses maintained more cells positive for cytokeratin-5, P63, and Ki-67 compared to those with Vifilcon A or without contact lens protection. Furthermore, less proinflammatory factors, including nuclear factor-kappa (p65), cyclooxygenase-2, Fas L, and Fas, were induced in the corneas protected by Etafilcon A and HEMA+MA. Conclusions This study demonstrated various protective effects of weekly disposable contact lenses against UVB irradiation. The mouse model used in the present study may be used extensively for in vivo assessment of UV shield efficacy. PMID:23734085

  10. Optical and vibrational properties of phosphorylcholine-based contact lenses-Experimental and theoretical investigations.

    PubMed

    Filipecka, Katarzyna; Miedziński, Rafał; Sitarz, Maciej; Filipecki, Jacek; Makowska-Janusik, Małgorzata

    2017-04-05

    The Raman, MIR and UV-vis spectroscopy have been used to characterize Omafilcon A material constructing the one of the Proclear family contact lenses. The Omafilcon A is hydrogel material composed of 2-hydroxyethyl methacrylate (HEMA) and 2-methacryloyloxyethyl phosphorylcholine (PC) polymers crosslinked with ethyleneglycol dimethacrylate (EGDMA). Vibrational and electronic properties of the Omafilcon A material were also investigated by quantum chemical calculations. Experimentally obtained Raman, MIR and optical spectra were compared to the theoretical ones calculated applying RHF and DFT methodology. The quantum chemical calculations were performed for isolated monomers of lenses compounds as well as for their dimers and trimers to elucidate the effect of Omafilcon A polymerization and the role of an individual components.

  11. Fitting of aspheric high gas-permeable rigid contact lenses to scarred corneas.

    PubMed

    Kok, J H; Smulders, F; van Mil, C

    1991-08-15

    Scarring of the cornea often results in an irregular corneal surface, which causes scattering in light perception. Therefore, the impaired visual acuity cannot be adequately corrected by spectacles in most cases. In this study, high oxygen-transmissible aspheric rigid lenses were fitted, with computer assistance, in 26 scarred eyes of 23 consecutive patients. In 15 of 26 eyes (57.7%), a successful fitting with good vision, no complications, and a sufficiently long wearing time was accomplished. The main lens-related complications included fluorescein-staining epithelial defects in five of 26 eyes (19.2%) and epithelial edema in two of 26 eyes (7.7%). Computer-aided fitting was of limited value because keratometer readings were not measurable in 50% of the cases. The results of this study indicate that the application of high oxygen-transmissible aspheric rigid contact lenses may obviate corneal surgery.

  12. Optical and vibrational properties of phosphorylcholine-based contact lenses-Experimental and theoretical investigations

    NASA Astrophysics Data System (ADS)

    Filipecka, Katarzyna; Miedziński, Rafał; Sitarz, Maciej; Filipecki, Jacek; Makowska-Janusik, Małgorzata

    2017-04-01

    The Raman, MIR and UV-vis spectroscopy have been used to characterize Omafilcon A material constructing the one of the Proclear family contact lenses. The Omafilcon A is hydrogel material composed of 2-hydroxyethyl methacrylate (HEMA) and 2-methacryloyloxyethyl phosphorylcholine (PC) polymers crosslinked with ethyleneglycol dimethacrylate (EGDMA). Vibrational and electronic properties of the Omafilcon A material were also investigated by quantum chemical calculations. Experimentally obtained Raman, MIR and optical spectra were compared to the theoretical ones calculated applying RHF and DFT methodology. The quantum chemical calculations were performed for isolated monomers of lenses compounds as well as for their dimers and trimers to elucidate the effect of Omafilcon A polymerization and the role of an individual components.

  13. Surface properties and wear performances of siloxane-hydrogel contact lenses.

    PubMed

    Bettuelli, Michela; Trabattoni, Silvia; Fagnola, Matteo; Tavazzi, Silvia; Introzzi, Laura; Farris, Stefano

    2013-11-01

    The low surface roughness of disposable contact lenses made of a new siloxane-hydrogel loaded with hyaluronic acid is reported, as studied by atomic force microscopy (AFM). Before the wear, the surface is characterized by out-of-plane and sharp structures, with maximum height of about 10 nm. After a wear of 8 h, evidence of two typical morphologies is provided and discussed. One morphology (sharp type) has a similar aspect as the unworn lenses with a slight increase in both the height and the number of the sharp peaks. The other morphology (smooth type) is characterized by troughs and bumpy structures. Wettability and clinical performances are also discussed, the latter deduced by the ocular-surface-disease index (OSDI). The main finding arising from this work is the indication of correlation between the change of the OSDI before and after wear and the lens surface characteristics obtained by AFM.

  14. In-vitro interferometric characterization of dynamic fluid layers on contact lenses

    NASA Astrophysics Data System (ADS)

    Primeau, Brian C.; Greivenkamp, John E.; Sullivan, John J.

    2011-08-01

    The anterior refracting surface of the eye when wearing a contact lens is the thin fluid layer that forms on the surface of the contact lens. Under normal conditions, this fluid layer is less than 10 microns thick. The fluid layer thickness and topography change over time and are affected by the material properties of the contact lens, and may affect vision quality and comfort. An in vitro method of characterizing dynamic fluid layers applied to contact lenses mounted on mechanical substrates has been developed using a phase-shifting Twyman-Green interferometer. This interferometer continuously measures light reflected from the surface of the fluid layer, allowing precision analysis of the dynamic fluid layer. Movies showing this fluid layer behavior can be generated. The fluid behavior on the contact lens surface is measured, allowing quantitative analysis beyond what typical contact angle or visual inspection methods provide. The interferometer system has measured the formation and break up of fluid layers. Different fluid and contact lens material combinations have been used, and significant fluid layer properties have been observed in some cases. The interferometer is capable of identifying features in the fluid layer less than a micron in depth with a spatial resolution of about ten microns. An area on the contact lens approximately 6 mm wide can be measured with the system. This paper will discuss the interferometer design and analysis methods used. Measurement results of different material and fluid combinations are presented.

  15. Interferometer and analysis methods for the in vitro characterization of dynamic fluid layers on contact lenses

    NASA Astrophysics Data System (ADS)

    Primeau, Brian C.; Greivenkamp, John E.

    2012-06-01

    The anterior refracting surface of the eye when wearing a contact lens is the thin fluid layer that forms on the surface of the contact lens. Under normal conditions, this fluid layer is less than 10 μm thick. The fluid layer thickness and topography change over time and are affected by the material properties of the contact lens and may affect vision quality and comfort. An in vitro method of characterizing dynamic fluid layers applied to contact lenses mounted on mechanical substrates has been developed by use of a phase-shifting Twyman-Green interferometer. This interferometer continuously measures light reflected from the surface of the fluid layer, allowing precision analysis of the dynamic fluid layer. Movies showing this fluid layer behavior can be generated. Quantitative analysis beyond typical contact angle or visual inspection methods is provided. Different fluid and contact lens material combinations have been evaluated, and variations in fluid layer properties have been observed. This paper discusses the interferometer design and analysis methods used. Example measurement results of different contact lens are presented.

  16. Is it safe to wear contact lenses with a full-facepiece respirator

    SciTech Connect

    Da Roza, R.A.; Weaver, C.

    1985-08-16

    The Federal OSHA regulation that prohibits the wearing of contact lenses while using a respirator is being challenged by users. We surveyed 9100 fire fighters around the US and Canada to determine if the wearing of contacts while using a self-contained breathing apparatus (SCBA) had caused any serious problems to warrant this strict regulation. Of the 1405 questionnaires returned, 403 fire fighters do wear contacts with SCBA, despite the regulation. Of these, only six responded that contact-lens related problems had caused them to remove the facepiece in an environment in which the facepiece would normally be worn. In contrast, the safety-related problems caused by eyeglasses in SCBA - which are legal - are proportionately higher. Over half of the supervisors returning the questionnaire admitted that some of their employees wear contacts with SCBA; however, these supervisors knew of only eight cases when contact-lens problems had caused the facepiece to be removed when it should not have been. Our investigation has indicated that these problems were not significantly hazardous. We believe that the use of contacts with a respirator should not be prohibited. 7 refs., 2 figs., 7 tabs.

  17. Extended-wear of high oxygen-permeable quantum contact lenses.

    PubMed

    Kok, J H; Hilbrink, H J; Rosenbrand, R M; Visser, R

    1992-03-01

    This study was performed to investigate the effects of extended-wear of rigid aspherical high gas-permeable contact lenses on the cornea. In the study 32 subjects (62 eyes) were followed over a period of 3 to 24 months. A high gas-permeable contact lens (Dk 92), made of fluoro-silicone-acrylate copolymer, was used. Vision remained constant during the studied period. The corneal thickness decreased significantly (p less than 0.05) during the first six months. Significant changes (p less than 0.05) were found after three months in the corneal curvature, especially in the vertical meridian. No further topographical changes were noted in the period between three and six months of extended-wear. Complications, like acute red eye syndrome and bacterial infections, which may be encountered in soft lens extended-wear, were not noticed. At the end of the study 20 subjects (38 eyes, 61%) were still on extended-wear, 9 subjects (18 eyes, 29%) changed to daily wear and 3 subjects (six eyes, 10%) became unavailable for follow-up. Extended-wear of rigid aspherical high gas-permeable contact lenses may be considered as an acceptable alternative for soft lens extended-wear.

  18. Microscopic observation of unworn siloxane-hydrogel soft contact lenses by atomic force microscopy.

    PubMed

    González-Méijome, José M; López-Alemany, Antonio; Almeida, José B; Parafita, Manuel A; Refojo, Miguel F

    2006-02-01

    In the present study, samples of lotrafilcon A, balafilcon A, and galyfilcon A contact lenses were observed by atomic force microscopy (AFM) in tapping mode at areas ranging from 0.25 to 400 microm2. Mean roughness (Ra), root-mean-square roughness (Rms) and maximum roughness (Rmax) in nanometers were obtained for the three lens materials at different magnifications. The three contact lenses showed significantly different surface topography. However, roughness values were dependent of the surface area to be analyzed. For a 1 microm2 area, statistics revealed a significantly more irregular surface of balafilcon A (Ra = 6.44 nm; Rms = 8.30 nm; Rmax = 96.82 nm) compared with lotrafilcon A (Ra = 2.40 nm; Rms = 3.19 nm; Rmax = 40.89 nm) and galyfilcon A (Ra = 1.40 nm; Rms = 1.79 nm; Rmax = 15.33 nm). Ra and Rms were the most consistent parameters, with Rmax presenting more variability for larger surface areas. The higher roughness of balafilcon A is attributed to the plasma oxidation treatment used to improve wettability. Conversely, galyfilcon A displays a smoother surface. Present observations could have implications in clinical aspects of siloxane-hydrogel contact lens wear such as lens spoliation, resistance to bacterial adhesion, or mechanical interaction with the ocular surface.

  19. In vitro water wettability of silicone hydrogel contact lenses determined using the sessile drop and captive bubble techniques.

    PubMed

    Maldonado-Codina, Carole; Morgan, Philip B

    2007-11-01

    This study investigated the water contact angles of five commercially available silicone hydrogel contact lenses (Acuvue Advance, Acuvue Oasys, Focus Night & Day, O2 Optix, and PureVision) using sessile drop and captive bubble techniques. The only lens type that showed a significant difference in water contact angle when measured by sessile drop direct from the blister compared with after 48 h of soaking/washing in saline was the Acuvue Advance lens (from 66 degrees to 96 degrees, respectively) (p=0.0002), presumably because of surface active agents within the blister solution. The water contact angle data split the lenses into two distinct groups (plenses demonstrated relatively high sessile drop measures and relatively low captive bubble values (thereby displaying significant hysteresis) whereas the Focus Night & Day and O2 Optix lenses showed relatively low sessile drop measures and relatively high captive bubble values (with little hysteresis). Contact angle analysis of hydrogel lens surfaces is highly methodologically dependent and may be able to predict the clinical performance of contact lenses in vivo.

  20. Comparison of tear osmolarity and ocular comfort between daily disposable contact lenses: hilafilcon B hydrogel versus narafilcon A silicone hydrogel.

    PubMed

    Sarac, Ozge; Gurdal, Canan; Bostancı-Ceran, Basak; Can, Izzet

    2012-06-01

    The aim of this study was to evaluate tear osmolarity and ocular comfort with two different types of hydrogel daily disposable lenses. The right eyes of 15 first-time contact lens users were included in this prospective study. All eyes wore hilafilcon B silicone hydrogel contact lenses for 8 h (group 1). After 1 week without contact lenses, all eyes wore narafilcon A silicone hydrogel contact lenses for 8 h (group 2). Tear osmolarity measurement was performed before and after 4 and 8 h of each contact lens wear. Ocular comfort was assessed after 4 and 8 h of each contact lens wear. In group 1, the mean baseline, 4- and 8-h tear osmolarity values were 293 ± 10.57, 303.00 ± 10.5 mOsm/L (p = 0.023), and 295.0 ± 1.4 mOsm/L (p > 0.05), respectively. In group 2, the mean baseline, 4- and 8-h tear osmolarity values were 294 ± 13.65, 300.9 ± 11.3 mOsm/L (p = 0.007), and 298.80 ± 7.2 mOsm/L (p > 0.05), respectively. In group 1, the mean comfort score was 7.20 ± 0.45 and 8.60 ± 0.45 at 4 and 8 h, respectively (p = 0.038). In group 2, the mean comfort score significantly decreased from 9.80 ± 0.45 to 7.80 ± 0.84 at 4 h (p = 0.039). Both hydrogel and silicone hydrogel daily disposable contact lenses elevated tear osmolarity during 8 h of contact lens wear. The increase in tear osmolarity with both contact lenses was below the cut-off value for dry eye and was not associated with ocular comfort.

  1. In situ oxygen transmissibility of rigid gas-permeable contact lenses.

    PubMed

    Weissman, B A; Fatt, I

    1988-05-01

    On the eye a contact lens is bathed in tear fluid, which increases its resistance to oxygen flux. For rigid gas-permeable lenses, this effect should be small during open-eye wear because a large amount of oxygen is provided by air-saturated tears that are pumped under the lens. However, under closed-eye conditions this study suggests substantial decrease in overall lens system oxygen transmissibility when lens transmissibility itself is greater than 20 x 10(-9) cm ml O2/s ml mm Hg and when the average thickness of the tear layer is greater than about 20 micron.

  2. Dynamic Simulation of the Effect of Soft Toric Contact Lenses Movement on Retinal Image Quality

    PubMed Central

    Niu, Yafei; Sarver, Edwin J.; Stevenson, Scott B.; Marsack, Jason D.; Parker, Katrina E.; Applegate, Raymond A.

    2008-01-01

    Purpose To report the development of a tool designed to dynamically simulate the effect of soft toric contact lens movement on retinal image quality, initial findings on three eyes, and the next steps to be taken to improve the utility of the tool. Methods Three eyes of two subjects wearing soft toric contact lenses were cyclopleged with 1% cyclopentolate and 2.5% phenylephrine. Four hundred wavefront aberration measurements over a 5-mm pupil were recorded during soft contact lens wear at 30 Hz using a complete ophthalmic analysis system aberrometer. Each wavefront error measurement was input into Visual Optics Laboratory (version 7.15, Sarver and Associates, Inc.) to generate a retinal simulation of a high contrast log MAR visual acuity chart. The individual simulations were combined into a single dynamic movie using a custom MatLab PsychToolbox program. Visual acuity was measured for each eye reading the movie with best cycloplegic spectacle correction through a 3-mm artificial pupil to minimize the influence of the eyes’ uncorrected aberrations. Comparison of the simulated acuity was made to values recorded while the subject read unaberrated charts with contact lenses through a 5-mm artificial pupil. Results For one study eye, average acuity was the same as the natural contact lens viewing condition. For the other two study eyes visual acuity of the best simulation was more than one line worse than natural viewing conditions. Conclusions Dynamic simulation of retinal image quality, although not yet perfect, is a promising technique for visually illustrating the optical effects on image quality because of the movements of alignment-sensitive corrections. PMID:18382338

  3. Myopia Control with Orthokeratology Contact Lenses in Spain (MCOS): Study Design and General Baseline Characteristics

    PubMed Central

    Santodomingo-Rubido, Jacinto; Villa-Collar, César; Gilmartin, Bernard; Gutiérrez-Ortega, Ramón

    2010-01-01

    Purpose Although previous studies suggest that orthokeratology contact lens wear slows eye growth in children with progressing myopia, some limitations in the methodology employed have become evident. Furthermore, the safety of this modality of visual correction has not been assessed. The study “Myopia Control with Orthokeratology Contact Lenses in Spain” (MCOS) is being conducted to compare axial length growth between white European myopic children wearing orthokeratology contact lenses (OK) and wearing distance single-vision spectacles (SV). Additionally, the incidence of adverse events and discontinuations is also recorded. We outline the methodology and baseline data adopted. Methods Subjects aged 6 to 12, with myopia ranging from 0.75 to 4.00 D and astigmatism ≤1.00 D were prospectively allocated OK or SV correction. Measurements of axial length, anterior chamber depth, corneal topography, cycloplegic autorefraction, visual acuity and corneal staining are performed at 6-month intervals. The incidence of adverse events and discontinuations are also recorded. Results Thirty one children were fitted with OK and 31 with SV correction. Eight subjects did not meet the refraction-related inclusion criteria for enrollment. No significant differences were found in baseline mean age and refractive and biometric data betwseen the two groups (P>0.05). No adverse events were found in any of the two groups at baseline. Conclusion To the authors’ knowledge, MCOS is the first prospective clinical trial to assess the safety and efficacy of orthokeratology contact lens wear to slow myopia progression vs. single-vision spectacle wear. The MCOS offers a number of notable features: prospective design; well-matched samples and high-resolution ocular biometry measures, which should collectively elucidate whether orthokeratology contact lens wear is a feasible and safe method for myopia-progression control.

  4. Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

    PubMed Central

    Szczotka-Flynn, Loretta B.; Pearlman, Eric; Ghannoum, Mahmoud

    2012-01-01

    Purpose A contact lens (CL) can act as a vector for microorganisms to adhere to and transfer to the ocular surface. Commensal microorganisms that uneventfully cohabitate on lid margins and conjunctivae and potential pathogens that are found transiently on the ocular surface can inoculate CLs in vivo. In the presence of reduced tissue resistance, these resident microorganisms or transient pathogens can invade and colonize the cornea or conjunctiva to produce inflammation or infection. Methods The literature was reviewed and used to summarize the findings over the last 30 years on the identification, enumeration, and classification of microorganisms adherent to CLs and their accessories during the course of normal wear and to hypothesize the role that these microorganisms play in CL infection and inflammation. Results Lens handling greatly increases the incidence of lens contamination, and the ocular surface has a tremendous ability to destroy organisms. However, even when removed aseptically from the eye, more than half of lenses are found to harbor microorganisms, almost exclusively bacteria. Coagulase-negative Staphylococci are most commonly cultured from worn lenses; however, approximately 10% of lenses harbor Gram-negative and highly pathogenic species, even in asymptomatic subjects. In storage cases, the incidence of positive microbial bioburden is also typically greater than 50%. All types of care solutions can become contaminated, including up to 30% of preserved products. Conclusions The process of CL-related microbial keratitis and inflammation is thought to be preceded by the presence or transfer or both of microorganisms from the lens to the ocular surface. Thus, this detailed understanding of lens-related bioburden is important in the understanding of factors associated with infectious and inflammatory complications. Promising mechanisms to prevent bacterial colonization on lenses and lens cases are forthcoming, which may decrease the incidence of

  5. Smart Contact Lenses with Graphene Coating for Electromagnetic Interference Shielding and Dehydration Protection.

    PubMed

    Lee, Sangkyu; Jo, Insu; Kang, Sangmin; Jang, Bongchul; Moon, Joonhee; Park, Jong Bo; Lee, Soochang; Rho, Sichul; Kim, Youngsoo; Hong, Byung Hee

    2017-02-21

    Recently, smart contact lenses with electronic circuits have been proposed for various sensor and display applications where the use of flexible and biologically stable electrode materials is essential. Graphene is an atomically thin carbon material with a two-dimensional hexagonal lattice that shows outstanding electrical and mechanical properties as well as excellent biocompatibility. In addition, graphene is capable of protecting eyes from electromagnectic (EM) waves that may cause eye diseases such as cataracts. Here, we report a graphene-based highly conducting contact lens platform that reduces the exposure to EM waves and dehydration. The sheet resistance of the graphene on the contact lens is as low as 593 Ω/sq (±9.3%), which persists in an wet environment. The EM wave shielding function of the graphene-coated contact lens was tested on egg whites exposed to strong EM waves inside a microwave oven. The results show that the EM energy is absorbed by graphene and dissipated in the form of thermal radiation so that the damage on the egg whites can be minimized. We also demonstrated the enhanced dehydration protection effect of the graphene-coated lens by monitoring the change in water evaporation rate from the vial capped with the contact lens. Thus, we believe that the graphene-coated contact lens would provide a healthcare and bionic platform for wearable technologies in the future.

  6. The role of multi-purpose solutions in prevention and removal of lipid depositions on contact lenses.

    PubMed

    Tam, Ngai Keung; Pitt, William G; Perez, Krystian X; Handly, Erika; Glenn, Andrew A; Hickey, John W; Larsen, Brian G

    2014-12-01

    The sorption and desorption of radiolabeled dipalmitoylphosphatidylcholine (DPPC) and cholesterol (CH) were measured on 5 types of commercial contact lenses. The lenses were soaked in vitro in an artificial tear fluid for 16h. The effects of borate buffered saline and two commercial multi-purpose lens-care solutions (MPSs) on reducing the lipid (DPPC and CH) sorption and increasing the lipid removal were examined. The results showed that silicone hydrogel (SiHy) lenses accumulated the most lipids, sorbing over an order of magnitude more than polymacon, a conventional hydrogel lens. Pre-soaking the SiHy lenses for 16h in MPSs reduced the DPPC sorption by up to 13% and the CH sorption by up to 11%, compared to controls that were not pre-soaked. However neither these reductions nor those on polymacon were statistically significant (p>0.05). In sorption experiments without presoaking, subsequent exposure to the MPSs removed some DPPC from the lenses (0-3.1% for SiHy lenses and 14-55% for polymacon), but CH removal was 0.0-0.8% for SiHy lenses and 0.6-28% for polymacon lenses. Some of these removals were statistically significant (p<0.05).

  7. Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses.

    PubMed

    White, Charles J; McBride, Matthew K; Pate, Kayla M; Tieppo, Arianna; Byrne, Mark E

    2011-08-01

    Symptoms of contact lenses induced dry eye (CLIDE) are typically treated through application of macromolecular re-wetting agents via eye drops. Therapeutic soft contact lenses can be formulated to alleviate CLIDE symptoms by slowly releasing comfort agent from the lens. In this paper, we present an extended wear silicone hydrogel contact lens with extended, controllable release of 120 kDa hydroxypropyl methylcellulose (HPMC) using a molecular imprinting strategy. A commercial silicone hydrogel lens was tailored to release approximately 1000 μg of HPMC over a period of up to 60 days in a constant manner at a rate of 16 μg/day under physiological flowrates, releasing over the entire range of continuous wear. Release rates could be significantly varied by the imprinting effect and functional monomer to template ratio (M/T) with M/T values 0, 0.2, 2.8, 3.4 corresponding to HPMC release durations of 10, 13, 23, and 53 days, respectively. Lenses had high optical quality and adequate mechanical properties for contact lens use. This work highlights the potential of imprinting in the design and engineering of silicone hydrogel lenses to release macromolecules for the duration of wear, which may lead to decreased CLIDE symptoms and more comfortable contact lenses.

  8. Demodex sp. as a Potential Cause of the Abandonment of Soft Contact Lenses by Their Existing Users.

    PubMed

    Tarkowski, Witold; Moneta-Wielgoś, Joanna; Młocicki, Daniel

    2015-01-01

    Demodex mites may be a potential etiological factor in the development of various eye and skin disorders. The aim of the study was to investigate the presence of Demodex in the hair follicles of eyelashes and their potential influence on abandoning soft contact lenses which had been previously well tolerated by their users. A group of 62 users of contact lenses (28 with emerging discomfort and 34 without discomfort) were examined. There is a need to check the existence of a relationship between D. folliculorum or/and D. brevis infestation and the emergence of intolerance to the presence of soft contact lenses. The removed lashes were examined under light microscopy, applying standard parasitological methods if demodicosis is suspected. A positive result was assumed if at least one adult stage, larva, protonymph/nymph, or egg of D. folliculorum and/or D. brevis was present. A positive correlation was observed between the presence of Demodex and intolerance to contact lenses by their existing users (p < 0.05), and Demodex sp. infections were observed in 92.86% of patients with intolerance to contact lenses. Our results provide further evidence for the pathogenic role played by the mites in the development of eye diseases.

  9. Demodex sp. as a Potential Cause of the Abandonment of Soft Contact Lenses by Their Existing Users

    PubMed Central

    Tarkowski, Witold; Moneta-Wielgoś, Joanna; Młocicki, Daniel

    2015-01-01

    Demodex mites may be a potential etiological factor in the development of various eye and skin disorders. The aim of the study was to investigate the presence of Demodex in the hair follicles of eyelashes and their potential influence on abandoning soft contact lenses which had been previously well tolerated by their users. A group of 62 users of contact lenses (28 with emerging discomfort and 34 without discomfort) were examined. There is a need to check the existence of a relationship between D. folliculorum or/and D. brevis infestation and the emergence of intolerance to the presence of soft contact lenses. The removed lashes were examined under light microscopy, applying standard parasitological methods if demodicosis is suspected. A positive result was assumed if at least one adult stage, larva, protonymph/nymph, or egg of D. folliculorum and/or D. brevis was present. A positive correlation was observed between the presence of Demodex and intolerance to contact lenses by their existing users (p < 0.05), and Demodex sp. infections were observed in 92.86% of patients with intolerance to contact lenses. Our results provide further evidence for the pathogenic role played by the mites in the development of eye diseases. PMID:26290865

  10. The level of improvement of visual acuity in high corneal astigmatism with rigid gas permeable contact lenses.

    PubMed

    Opačić, Dalibor; Miljak, Snježana; Ćuruvija-Opačić, Ksenija

    2015-03-01

    The aim of this study was to calculate the level of improvement of visual acuity comparing the best corrected visual acuity (VA) achieved with spectacles with the best corrected VA achieved with rigid gas permeable (RGP) contact lenses in patients with high, simple or compound corneal astigmatism (myopic, hypermetropic and mixed). The investigation of patients included auto-kerato-refractometry, manual keratometry, corneal topography and visual acuity with Snellen chart. The best corrected VA obtained with spectacles was compared with the best corrected VA obtained with RGP contact lenses in 72 patients (116 eyes). All patients showed a significant improvement in visual acuity with RGP lenses from one to seven lines compared to spectacles (p = 0.0001). Level of improvement in VA represented as the number of lines obtained was as follows: 74 percent of patients got two to four lines more in VA with RGP lenses compared to spectacles, and almost 10 percent of patients got five to seven lines. RGP contact lenses provide a significant improvement in VA compared to VA reached with spectacles in patients with high corneal astigmatism. The benefit in VA with RGP lenses is higher as the astigmatism is higher.

  11. Topographic characterization of unworn contact lenses assessed by atomic force microscopy and wavelet transform.

    PubMed

    Ţălu, Ştefan; StȨpień, Krzysztof; Caglayan, Mustafa Oguzhan

    2015-11-01

    This paper analyses the three-dimensional (3-D) surface morphology of optic surface of unworn contact lenses (CLs) using atomic force microscopy (AFM) and wavelet transform. Refractive powers of all lens samples were 2.50 diopters. Topographic images were acquired in contact mode in air-conditioned medium (35% RH, 23°C). Topographic measurements were taken over a 5 µm × 5 µm area with 512 pixel resolution. Resonance frequency of the tip was 65 kHz. The 3-D surface morphology of CL unworn samples revealed (3-D) micro-textured surfaces that can be analyzed using (AFM) and wavelet transform. AFM and wavelet transform are accurate and sensitive tools that may assist CL manufacturers in developing CLs with optimal surface characteristics.

  12. Corneal epithelial response of the primate eye to gas permeable corneal contact lenses: a preliminary report.

    PubMed

    Bergmanson, J P; Ruben, M; Chu, L W

    1984-01-01

    The comparative corneal epithelial effects of rigid gas permeable and soft contact lenses are reported in the present preliminary study using two bush baby monkeys (Galago senegalensis). Both types of lenses produced early cell death among the surface squamous cells while internally the epithelium and its nerve fibers remained normal. Sporadically small abnormal groups of cells involving two to three of the surface layers were observed in both the hard and soft lens wearing corneas. It was concluded that this represented superficial punctate keratitis (SPK). Small superficial intracellular epithelial cysts with membranous contents were infrequently noted in the gas permeable lens wearing cornea and it is suggested here that they were mild forms or precursors of those seen clinically in human corneas. Since the gas permeable lens met the corneal oxygen requirement it is postulated that the traumatic effect of the rigidity of the lens caused the cystic formation to occur. The relative hypoxia induced by the soft contact lens resulted in a mild superficial epithelial edema.

  13. Peripheral refraction with different designs of progressive soft contact lenses in myopes

    PubMed Central

    Allinjawi, Kareem; Sharanjeet-Kaur, Sharanjeet-Kaur; Akhir, Saadah Mohamed; Mutalib, Haliza Abdul

    2016-01-01

    Aim: The purpose of this study was to compare the changes in relative peripheral refractive error produced by two different designs of progressive soft contact lenses in myopic schoolchildren. Methods: Twenty-seven myopic schoolchildren age between 13 to 15 years were included in this study. The measurements of central and peripheral refraction were made using a Grand-Seiko WR-5100K open-field autorefractometer without correction (baseline), and two different designs of progressive contact lenses (PCLs) (Multistage from SEED & Proclear from Cooper Vision) with an addition power of +1.50 D. Refractive power was measured at center and at eccentricities between 35º temporal to 35º nasal visual field (in 5º steps). Results: Both PCLs showed a reduction in hyperopic defocus at periphery. However, this reduction was only significant for the Multistage PCL (p= 0.015), (Proclear PCL p= 0.830).  Conclusion: Multistage PCLs showed greater reduction in peripheral retinal hyperopic defocus among myopic schoolchildren in comparison to Proclear PCLs. PMID:28163898

  14. Peripheral refraction with different designs of progressive soft contact lenses in myopes.

    PubMed

    Allinjawi, Kareem; Sharanjeet-Kaur, Sharanjeet-Kaur; Akhir, Saadah Mohamed; Mutalib, Haliza Abdul

    2016-01-01

    Aim: The purpose of this study was to compare the changes in relative peripheral refractive error produced by two different designs of progressive soft contact lenses in myopic schoolchildren. Methods: Twenty-seven myopic schoolchildren age between 13 to 15 years were included in this study. The measurements of central and peripheral refraction were made using a Grand-Seiko WR-5100K open-field autorefractometer without correction (baseline), and two different designs of progressive contact lenses (PCLs) (Multistage from SEED & Proclear from Cooper Vision) with an addition power of +1.50 D. Refractive power was measured at center and at eccentricities between 35º temporal to 35º nasal visual field (in 5º steps). Results: Both PCLs showed a reduction in hyperopic defocus at periphery. However, this reduction was only significant for the Multistage PCL (p= 0.015), (Proclear PCL p= 0.830).  Conclusion: Multistage PCLs showed greater reduction in peripheral retinal hyperopic defocus among myopic schoolchildren in comparison to Proclear PCLs.

  15. Hyaluronic acid as an internal wetting agent in model DMAA/TRIS contact lenses.

    PubMed

    Weeks, Andrea; Luensmann, Doerte; Boone, Adrienne; Jones, Lyndon; Sheardown, Heather

    2012-11-01

    Model silicone hydrogel contact lenses, comprised of N,N-dimethylacrylamide and methacryloxypropyltris (trimethylsiloxy) silane, were fabricated and hyaluronic acid (HA) was incorporated as an internal wetting agent using a dendrimer-based method. HA and dendrimers were loaded into the silicone hydrogels and cross-linked using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide chemistry. The presence and location of HA in the hydrogels was confirmed using X-ray photoelectron spectroscopy and confocal laser scanning microscopy, respectively. The effects of the presence of HA on the silicone hydrogels on hydrophilicity, swelling behavior, transparency, and lysozyme sorption and denaturation were evaluated. The results showed that HA increased the hydrophilicity and the equilibrium water content of the hydrogels without affecting transparency. HA also significantly decreased the amount of lysozyme sorption (p < 0.002). HA had no effect on lysozyme denaturation in hydrogels containing 0% and 1.7% methacrylic acid (MAA) (by weight) but when the amount of MAA was increased to 5%, the level of lysozyme denaturation was significantly lower compared to control materials. These results suggest that HA has great potential to be used as a wetting agent in silicone hydrogel contact lenses to improve wettability and to decrease lysozyme sorption and denaturation.

  16. Extended Latanoprost Release from Commercial Contact Lenses: In Vitro Studies Using Corneal Models

    PubMed Central

    Mohammadi, Saman; Jones, Lyndon; Gorbet, Maud

    2014-01-01

    In this study, we compared, for the first time, the release of a 432 kDa prostaglandin analogue drug, Latanoprost, from commercially available contact lenses using in vitro models with corneal epithelial cells. Conventional polyHEMA-based and silicone hydrogel soft contact lenses were soaked in drug solution ( solution in phosphate buffered saline). The drug release from the contact lens material and its diffusion through three in vitro models was studied. The three in vitro models consisted of a polyethylene terephthalate (PET) membrane without corneal epithelial cells, a PET membrane with a monolayer of human corneal epithelial cells (HCEC), and a PET membrane with stratified HCEC. In the cell-based in vitro corneal epithelium models, a zero order release was obtained with the silicone hydrogel materials (linear for the duration of the experiment) whereby, after 48 hours, between 4 to 6 of latanoprost (an amount well within the range of the prescribed daily dose for glaucoma patients) was released. In the absence of cells, a significantly lower amount of drug, between 0.3 to 0.5 , was released, (). The difference observed in release from the hydrogel lens materials in the presence and absence of cells emphasizes the importance of using an in vitro corneal model that is more representative of the physiological conditions in the eye to more adequately characterize ophthalmic drug delivery materials. Our results demonstrate how in vitro models with corneal epithelial cells may allow better prediction of in vivo release. It also highlights the potential of drug-soaked silicone hydrogel contact lens materials for drug delivery purposes. PMID:25207851

  17. Development and testing of new biologically-based polymers as advanced biocompatible contact lenses

    SciTech Connect

    Bertozzi, Carolyn R.

    2000-06-01

    Nature has evolved complex and elegant materials well suited to fulfill a myriad of functions. Lubricants, structural scaffolds and protective sheaths can all be found in nature, and these provide a rich source of inspiration for the rational design of materials for biomedical applications. Many biological materials are based in some fashion on hydrogels, the crosslinked polymers that absorb and hold water. Biological hydrogels contribute to processes as diverse as mineral nucleation during bone growth and protection and hydration of the cell surface. The carbohydrate layer that coats all living cells, often referred to as the glycocalyx, has hydrogel-like properties that keep cell surfaces well hydrated, segregated from neighboring cells, and resistant to non-specific protein deposition. With the molecular details of cell surface carbohydrates now in hand, adaptation of these structural motifs to synthetic materials is an appealing strategy for improving biocompatibility. The goal of this collaborative project between Prof. Bertozzi's research group, the Center for Advanced Materials at Lawrence Berkeley National Laboratory and Sunsoft Corporation was the design, synthesis and characterization of novel hydrogel polymers for improved soft contact lens materials. Our efforts were motivated by the urgent need for improved materials that allow extended wear, and essential feature for those whose occupation requires the use of contact lenses rather than traditional spectacles. Our strategy was to transplant the chemical features of cell surface molecules into contact lens materials so that they more closely resemble the tissue in which they reside. Specifically, we integrated carbohydrate molecules similar to those found on cell surfaces, and sulfoxide materials inspired by the properties of the carbohydrates, into hydrogels composed of biocompatible and manufacturable substrates. The new materials were characterized with respect to surface and bulk hydrophilicity, and

  18. Drying methods for XPS analysis of PureVision™, Focus ® Night&Day™ and conventional hydrogel contact lenses

    NASA Astrophysics Data System (ADS)

    Karlgard, Caroline C. S.; Sarkar, Dilip K.; Jones, Lyndon W.; Moresoli, Christine; Leung, K. T.

    2004-05-01

    The surface composition of hydrogel contact lenses that contain silicon-based monomers, PureVision™ (balafilcon A) and Focus ® Night&Day™ (lotrafilcon A), were investigated by X-ray photoelectron spectroscopy (XPS). Conventional and daily disposable hydrogel lenses based on hydroxyethyl methacrylate (HEMA) were also studied, with the commonly prescribed 1-day Acuvue ® lens (etafilcon A) used as a control. All the lenses were pre-washed and dehydrated by three different methods, including drying in air, drying in nitrogen or freezing with subsequent freeze-drying, before the XPS analysis. The lenses dried in air had more impurities on the surface, and the lenses that were freeze-dried lost transparency, suggesting that drying lenses in nitrogen is the preferred preparation method for XPS analysis. Surface compositions for all lens materials were obtained and this data can be used as a control/base-value for future analysis of the interactions of soft contact lens materials with chemicals such as drugs or tear components.

  19. Current applications and efficacy of scleral contact lenses — a retrospective study

    PubMed Central

    Severinsky, Boris; Millodot, Michel

    2010-01-01

    Purpose To evaluate the indications and efficacy of high gas permeable scleral contact lenses (GP-SCL). Methods A total database of 97 consecutive patients (140 eyes) fitted with GP-SCL between January 2003 and December 2008, was retrospectively analyzed to determine the benefits of fitting scleral lenses. All lenses were fitted by preformed technique and were non-fenestrated. Patients included keratoconus – 88 eyes (63 %); corneal irregularities after penetrating keratoplasty – 39 eyes (28 %); various ocular surface disorders: Stevens-Johnson syndrome (SJS), graft versus host disease (GVHD) and exposure keratopathy – 6 eyes (4 %); post refractive surgery keratoectasia – 4 eyes (3 %), and high refractive error – 3 eyes (2 %). Results Mean follow up was 27.5 months (range 1–71), mean wearing time in successful wearers group was 12.2 hours per day (range 10–16), mean wearing time in group of wearers who dropped out using GP-SCL, was 5.8 hours (range 3–8). Keratoconus patients achieved median best corrected visual acuity (BCVA) of 20/32, 84 % of patients achieved BCVA of 20/40 or more. The post keratoplasty group achieved median BCVA of 20/25, 92 % of patients achieved BCVA of 20/40 or better. In the other groups, median BCVA was as follows: ocular surface disorders – 20/50, keratoectasia – 20/30, high refractive error – 20/32. Positive fluid-venting was highly associated with successful GP-SCL wearing. Twenty patients (21 %) failed to wear GP-SCL. Conclusions GP-SCL's expand the management of various corneal abnormalities. The main indication for GP-SCL is optical correction of an irregular corneal surface, especially keratoconus and corneal transplant.

  20. The Competing Effects of Hyaluronic and Methacrylic Acid in Model Contact Lenses.

    PubMed

    Weeks, Andrea; Subbaraman, Lakshman N; Jones, Lyndon; Sheardown, Heather

    2012-01-01

    The aim of this study was to determine the influence of hyaluronic acid (HA) on lysozyme sorption in model contact lenses containing varying amounts of methacrylic acid (MAA). One model conventional hydrogel (poly(2-hydroxyethyl methacrylate) (pHEMA)) and two model silicone hydrogels (pHEMA, methacryloxypropyltris(trimethylsiloxy)silane (pHEMA TRIS) and N,N-dimethylacrylamide, TRIS (DMAA TRIS)) lens materials were prepared with and without MAA at two different concentrations (1.7 and 5%). HA, along with dendrimers, was loaded into these model contact lens materials and then cross-linked with 1-ethyl-3-(3-dimethylamino propyl)-carbodiimide (EDC). Equilibrium water content (EWC), advancing water contact angle and lysozyme sorption on these lens materials were investigated. In the HA-containing materials, the presence (P < 0.05) and amount (P < 0.05) of MAA increased the EWC of the materials. For most materials, addition of MAA reduced the advancing contact angles (P < 0.05) and for all the materials, the addition of HA further improved hydrophilicity (P < 0.05). For the non-HA containing hydrogels, the presence (P < 0.05) and amount (P < 0.05) of MAA increased lysozyme sorption. The presence of HA decreased lysozyme sorption for all materials (P < 0.05). MAA appears to work synergistically with HA to increase the EWC in addition to improving the hydrophilicity of model pHEMA-based and silicone hydrogel contact lens materials. Hydrogel materials that contain HA have tremendous potential as hydrophilic, protein-resistant contact lens materials.

  1. Biological oxygen apparent transmissibility of hydrogel contact lenses with and without organosilicon moieties.

    PubMed

    Compañ, V; López-Alemany, A; Riande, E; Refojo, M F

    2004-01-01

    The instrument oxygen transmissibility (IOT) of organosilicon hydrogels, measured by electrochemical procedures, is 5-10 times larger than that of conventional hydrogels. A method is described that allows the estimation of the oxygen tension at the lens-cornea interface for closed- and open-eyelids situations by combining the IOT of the hydrogels and corneal parameters such as corneal thickness, corneal permeability and oxygen flux across the cornea. From these results the biological oxygen apparent transmissibility (BOAT) is obtained, an important parameter which an multiplication with the pressure of oxygen on the external part of the lens gives the oxygen flux onto the cornea. Contact lenses with oxygen transmissibility higher than 100 Dk/t units [1 Dk/t unit=10(-9) [cm(3) O(2) (STp) cm(-2)s(-1)(mmHg)(-1)] posses a large oxygen tension at the lens-cornea interface that substantially reduces the oxygen flux onto the cornea. Lenses whose oxygen transmissibility is lower than 50 Dk/t units allow a rather small oxygen flux onto the cornea under closed eyelids condition that prevent their use for extended wear.

  2. Influence of the thermo-oxidative degradation on the chemical structure of contact lenses

    NASA Astrophysics Data System (ADS)

    Lira, Madalena; Alves, Carlos; Botelho, Gabriela

    2013-11-01

    In this work, four silicone-hydrogel contact lenses, Purevision® 2 (balafilcon A), Air Optix Aqua™ (lotrafilcon B), Acuvue® Oasys™ (senofilcon A) and Biofinity™ (comfilcon A), and one conventional lens, Acuvue® 2 (etafilcon A), were submitted during 5 weeks at a temperature of 37 °C under an air atmosphere. They were characterized initially and along exposure time in what concerns to the refractive index, water content, transmittance in the ultraviolet-visible region and chemical structure. From the results presented in this work it was possible to observe that in all lens the refractive index increases till 21 days and the water content decreased. At the end of the exposure these parameters are more variable depending on the lens studied. In what concerns to the transmittance in the ultraviolet-visible region it can be concluded that after exposure all lenses present a higher transmittance than initially. From this work it was possible to conclude that there were no significant changes in the wavenumbers where the main functional groups vibrate and in the intensity of the respective bands after 5 weeks of exposure.

  3. Artificial tear adsorption on soft contact lenses: methods to test surfactant efficacy.

    PubMed

    Rebeix, V; Sommer, F; Marchin, B; Baude, D; Tran, M D

    2000-06-01

    Spoilage is a primary factor in the biocompatibility of soft contact lenses (SCL) within the lacrimal fluid. Tears are a complex mixture of proteins, lipids, natural surfactants and salts. The spoilation process is due to a contribution of all these components and of the nature of SCL materials themselves. The aim of this study was to set up methods to observe and quantify lacrimal deposits and to select efficient surfactants for preventing protein deposits. The present study was performed on PMMA-NVP SCL. The behaviour of SCL in presence of tears was studied by means of an in vitro artificial tear model consisting of the main tears components and quantified by a colorimetric technique (BCA) performed directly on the lenses. The nature of the deposit was observed directly by atomic force microscopy (AFM) in a liquid medium showing the same adsorption trend noticed in the quantitative results and identifying specific adsorption sites. The assessment of surfactant adsorption was performed using Maron's method, as a mean to evaluate the affinity of surfactant to the surface, while the action of selected surfactants on pre-treated SCL was assessed using the BCA method. Promising results were obtained with these two different methods which can be used easily for the pre-selection of surfactants for further cleaning solution formulation studies.

  4. Fungal Keratitis Due to Beauveria bassiana in a Contact Lenses Wearer and Review of Published Reports.

    PubMed

    Lara Oya, Ana; Medialdea Hurtado, María Eloisa; Rojo Martín, María Dolores; Aguilera Pérez, Antonia; Alastruey-Izquierdo, Ana; Miranda Casas, Consuelo; Rubio Prats, Marina; Medialdea Marcos, Santiago; Navarro Marí, José María

    2016-10-01

    Fungal keratitis is a severe ocular infection that primarily affects subjects engaged in outdoor activities. Risk factors include allergic conjunctivitis, previous eye surgery, previous treatment with wide-spectrum antimicrobial agents and corticosteroids and using contact lenses. Corneal infection is usually secondary to trauma involving organic material, which is often the only predisposing factor. Early diagnosis based on clinical examination and microbiological investigation (microscopy, cultures and molecular techniques) is crucial to selecting the appropriate antifungal therapy and prevent progression. We report the case of a patient with keratitis due to Beauveria bassiana, an opportunistic and entomopathogenic filamentous fungus that is used as a biological insecticide and which is a rare cause of corneal infection. We review previous cases reports of B. bassiana keratitis published and its main features to compare with our case, a female occasional agriculture worker who had not suffered any trauma involving organic material. The patient received topical and oral antifungal therapy and debridement surgery, with a satisfactory outcome.

  5. Quantitative optical inspection of contact lenses immersed in wet cell using swept source OCT.

    PubMed

    Karnowski, Karol; Grulkowski, Ireneusz; Mohan, Nishant; Cox, Ian; Wojtkowski, Maciej

    2014-08-15

    We demonstrate swept source optical coherence tomography (OCT) imaging of contact lenses (CLs) in a wet cell and comprehensive quantitative characterization of CLs from volumetric OCT datasets. The approach is based on a technique developed for lens autopositioning and autoleveling enabled by lateral capillary interactions between the wet cell wall and the lens floating on the liquid surface. The demonstrated OCT imaging has enhanced contrast due to the application of a scattering medium and it improves visualization of both CL interfaces and edges. We also present precise and accurate three-dimensional metrology of soft and rigid CLs based on the OCT data. The accuracy and precision of the extracted lens parameters are compared with the manufacturer's specifications. The presented methodology facilitates industrial inspection methods of the CLs.

  6. Comparative evaluation of Comfilcon A and Senofilcon A bandage contact lenses after transepithelial photorefractive keratectomy

    PubMed Central

    Mukherjee, Achyut; Ioannides, Antonis; Aslanides, Ioannis

    2014-01-01

    Purpose To evaluate and compare Comfilcon A and Senofilcon A silicone hydrogel contact lenses used as a therapeutic bandage following transepithelial excimer laser photorefractive keratectomy (PRK). Methods Patients undergoing transepithelial PRK for myopia were prospectively recruited. Included patients had a Comfilcon A silicone hydrogel lens inserted in one eye, with a Senofilcon A lens in the contralateral eye. Postoperative assessment of subjective pain, epithelial healing and visual recovery was at day 1, 3 and 7. Contact lens factors including centration, movement and deposits were assessed. Results 48 eyes of 24 patients were included in the study. Mean age was 31 years (SD 11) and mean refractive error −4.5 D (SD 1.8). Mean pain score at day 1 was significantly higher in the Comfilcon group at 4.6 (SD 2.7) vs. 1.5 (SD2.5) in the Senofilcon group (P < 0.005). Mean time to healing was 3.17 days (SD 0.37) in the Comfilcon group, and 3.21 days (SD 0.4) in the Senofilcon group, with no difference in defect size. There was a pronounced central raphe in 1 eye in the Comfilcon group vs. 5 eyes in the Senofilcon group (P = 0.19). Significantly more eyes demonstrated no lens movement in the Senofilcon group (18 vs. 4, P = 0.0001). Conclusion The variation in material characteristics and lens geometry of different silicone hydrogel lenses affects their clinical characteristics in therapeutic roles. Other factors than oxygen permeability may affect pain and epithelial healing, with superior pain relief from the less permeable Senofilcon lens in this study. PMID:25649638

  7. Lipid deposition on hydrogel contact lenses: how history can help us today.

    PubMed

    Lorentz, Holly; Jones, Lyndon

    2007-04-01

    The tear film is a complex fluid that is precisely maintained and which is essential to the health of the ocular surface. One of the major components of the tear film is lipid, which is produced by the meibomian glands and serves many important functions on the ocular surface. It is estimated that there are more than 45 individual lipids within the tear film, which vary greatly in their structure and properties. The composition of the lipid within the tear film has an enormous influence on the stability of the tear film, with a subsequent impact on the occurrence of dry eye and the ultimate success of contact lens wear. The purpose of this review article is to describe the composition of the tear film lipids and their interaction with contact lens materials, with a particular emphasis on how the chemistry of novel silicone hydrogel materials has resulted in clinicians needing to understand the deposition of lipids onto contact lenses and how they may best manage this complication.

  8. Aberration changes of the corneal anterior surface following discontinued use of rigid gas permeable contact lenses1

    PubMed Central

    Yu, Qing; Wu, Jiang-Xiu; Zhang, He-Ning; Ye, Sheng; Dong, Shi-Qi; Zhang, Chen-Hao

    2013-01-01

    AIM To record aberrations with a corneal topographic device on the anterior surface of the cornea at different time-points prior to wearing and following discontinued use of rigid gas permeable (RGP) contact lenses. The effect of wearing RGP on the anterior surface of the cornea was discussed to provide guidance for clinical refractive error correction. METHODS The study objects were 24 eyes from 24 patients. All patients underwent identical examination procedures prior to lens use, as well as afterwards, including slit-lamp examination, non-contact tonometer measurement, computer optometry and corneal curvature measurement, subjective refraction test, and corneal topography analysis. The patients wore contact lenses everyday for 1 month and then discontinued. Corneal topographies were recorded at certain time points of 30 minutes, 1 day, 3, 7 and 14 days following use. RESULTS Total corneal aberration at each time point following discontinued use of RGP contact lenses was less than the time point prior to use. Detailed results were as follows: root mean square (RMS) (pre)=(1.438±0.328)µm, RMS (30 minutes)=(1.076±0.355)µm, RMS (1 day)=(1.362±0.402)µm, RMS (3 days)=(1.373±0.398)µm, RMS (7 days)=(1.387±0.415)µm, and RMS (14 days)=(1.430±0.423)µm. Results showed that at 30 minutes after discontinued use of RGP contact lenses, almost all 2nd- and 3rd-order aberrations change. Quadrafoil Z10 and spherical Z12 of the 4th-order were also changed. Alterations to Z5, Z6, and Z12 at 1 day after discontinued use were significant differences compared with the time period prior to RGP use: Z5 and Z6 decreased, and Z12 increased slightly. Z5 and Z6 remained decreased at 3 days after discontinued use, but Z9 and Z10 continued to increase and Z12 returned to levels prior to RGP use. At 14 days after discontinued use, all aberrations were not significantly different from the values prior to use. CONCLUSION The use RGP contact lenses greatly reduced total aberration of

  9. Bacterial adhesion measurements on soft contact lenses using a Modified Vortex Device and a Modified Robbins Device.

    PubMed

    Schultz, C L; Pezzutti, M R; Silor, D; White, R

    1995-09-01

    S. marcescens 8100 and P. aeruginosa 15442 were used to study bacterial adhesion to hydrogel contact lenses which had not been worn. Bacterial removal from unworn lens materials was assessed with a calibrated vortex device modified with a digital rpm readout and fitted with a test tube attachment (MVD). The MVD, which relies on a whirlpool-like force to remove the bacteria, showed that bacteria adhered to the same degree to etafilcon A, vifilcon A and polymacon lenses under standardized conditions. Tracking the isoenzyme patterns of these bacterial species over time showed instability of S. marcescens upon repeated passage. This instability was not evident with P. aeruginosa. Bacterial adhesion of P. aeruginosa 15442, to human worn and unworn etafilcon A materials was determined with a Modified Robbins Device. The MRD was closed off at both ends stopping medium and bacterial movement after 1 h of fluid flow over the lens surface. The results show that immediately following this 1-h period more bacteria adhere to unworn contact lenses than to worn lenses. However, bacterial counts were equivalent on worn and unworn lenses following 5 h of static incubation.

  10. The effects of daily-wear contact lenses on contrast sensitivity in selected professional and collegiate female tennis players.

    PubMed

    Kluka, D A; Love, P A

    1993-03-01

    Contrast sensitivity (CS) has recently emerged as an important predictor of visual performance. Few studies, however, have been published involving CS and its role in vision for sport. The purpose of this investigation was to determine if significant differences occurred in CS between female professional and collegiate tennis players who wore daily-wear soft contact lenses (N = 10) and those players who wore no corrective lenses (N = 10) in competition as measured by the Stereo Optical Optec 2000 Vision Tester. Subjects were between the ages of 18 and 37 years. Mean ages were 21.76 (+/- 4.018) and 25.40 (+/- 5.379) years for those wearing lenses and those not, respectively. Each subject was preliminarily screened for SVA-distance, lateral/vertical phorias, stereopsis, and color perception. All subjects were within accepted limits. CS was assessed at 1.5, 3, 6, 12, and 18 cycles per degree (cpd). Each subject was assessed monocularly; eye initially assessed was determined randomly. A 2 x 2 factorial analysis of variance (alpha = .05) was used to analyze data. No significant differences were found between eyes. Significant differences were found at 3, 6, 12, and 18 cpd. It may be concluded that those female professional and collegiate tennis players wearing no corrective lenses were significantly higher in CS at intermittent and high spatial frequencies than those who wore daily-wear soft contact lenses in competition.

  11. Comparison of results obtained with keratophakia, hypermetropic keratomileusis, intraocular lens implantation, and extended-wear contact lenses.

    PubMed

    Swinger, C A

    1983-01-01

    The limited experience with LRK precludes a valid comparison with IOLs and extended-wear contact lenses. Only observations, unsupported by valid statistical analysis, are possible. Some of these observations follow. Technically, LRK is very difficult. In their present form, the classic Barraquer procedures could never be used widely. However, if lenticle banks were to supply preground lenticles, the level of difficulty of LRK procedures would be comparable to IOL implantation. The magnitude of refractive correction possible with LRK compares favorably with that of contact lenses and IOLs. However, the accuracy of achieving a given correction is lower with LRK. Unlike contact lenses or IOLs, LRK induces both regular and irregular astigmatism. The latter accounts, in part, for the delayed visual result with LRK. The percentage of patients with 20/40 or better vision following LRK compares favorably with the percentages for contact lenses or IOLs, whereas the percentage of patients with 20/25 or better vision does not. This is true for at least 1 year following surgery. Compared to extended-wear contact lenses, IOLs and LRK typically require less commitment, fewer postoperative visits, and less expenditure by the patient, in terms of time and money, to achieve full-time correction. Although LRK is associated with a number of postoperative complications, none are known to be intraocular, and there have been no known reports of permanent severe visual loss. In contrast, the patient with an extended-wear contact lens or IOL is permanently at risk to develop sight-threatening complications. This is not the case with LRK, which has no known complications after the early postoperative period. Application of the IOL or extended-wear contact lens to the neonate or pediatric patient is associated with increased risk and difficulty. This may not be true with LRK, especially epikeratophakia. The major advantages of LRK appear to be permanent optical correction without the threat

  12. From Reading Stones, Glasses and Contact Lenses to Intraocular Lenses & Ophthalmic Lasers--A Short Overview over the History of Visual Aids.

    PubMed

    Scholtz, Sibylle K; Auffarth, Gerd U

    2012-01-01

    Alhazen, ibn al-Haytham, (965 Basra - c. 1040 in Cairo) was a Muslim polymath who made significant contributions to the principles of optics, being the first to recognize the optical effect by transparent objects in the 11th century. His insights led to a fundamental revolution, enabling older presbyopic persons to read again. Today many more options are available to help visually impaired people correct their sight defects. This article will give an historical overview of the sight aids which are available today and will describe the very first beginnings of the development of the "reading stone" or "glasses". Further, it will also give a chronological overview of more modern techniques, e.g., intraocular lenses, contact lenses and the options of refractive surgery.

  13. Bacterial Colonization of Disposable Soft Contact Lenses Is Greater during Corneal Infiltrative Events than during Asymptomatic Extended Lens Wear

    PubMed Central

    Sankaridurg, Padmaja R.; Sharma, Savitri; Willcox, Mark; Naduvilath, Thomas J.; Sweeney, Deborah F.; Holden, Brien A.; Rao, Gullapalli N.

    2000-01-01

    Microorganisms, especially gram-negative bacteria, are considered to play a role in the etiology of certain corneal infiltrative events (CIEs) observed during soft contact lens wear. This study explored the possibility of microbial colonization of soft contact lenses as a risk factor leading to CIEs. In a clinical trial conducted from March 1993 to January 1996, 330 subjects wore disposable soft contact lenses on a 6-night extended-wear and disposal schedule. During this period, 4,321 lenses (118 during CIEs; 4,203 during asymptomatic lens wear) were recovered aseptically and analyzed for microbial colonization. A greater percentage of lenses were free from microbial colonization during asymptomatic wear than during CIEs (42 versus 23%; P < 0.0001). The incidence of gram-positive bacteria, gram-negative bacteria and fungi was greater during CIEs than during asymptomatic lens wear (P < 0.05). During asymptomatic lens wear, gram-positive bacteria were isolated most frequently and were usually normal external ocular microbiota. Of the gram-positive bacteria, the incidence of Streptococcus pneumoniae was greater during CIE than during asymptomatic wear (7.6 versus 0.6%; P < 0.0001). While gram-negative bacteria were seen in few cases during asymptomatic wear, their incidence during CIE in comparison to asymptomatic wear was substantial and significant (23.7 versus 3.8%; P < 0.0001). Also, the level of colonization was high. Of CIEs, events of microbial keratitis, contact lens acute red eye, and asymptomatic infiltrative keratitis were associated with lens colonization with gram-negative bacteria or S. pneumoniae. Colonization of soft contact lenses with pathogenic bacteria, especially gram-negative bacteria and S. pneumoniae, appears to be a significant risk factor leading to CIE. PMID:11101574

  14. Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion.

    PubMed

    Pimenta, A F R; Ascenso, J; Fernandes, J C S; Colaço, R; Serro, A P; Saramago, B

    2016-12-30

    Optimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coefficients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorhexidine, levofloxacin and diclofenac. Equilibrium partition coefficients were determined at different ionic strength and pH, using water (pH 5.6) and PBS (pH 7.4). The measured partition coefficients were related with the polymer volume fraction in the hydrogel, through the introduction of an enhancement factor following the approach developed by the group of C. J. Radke (Kotsmar et al., 2012; Liu et al., 2013). This factor may be decomposed in the product of three other factors EHS, Eel and Ead which account for, respectively, hard-sphere size exclusion, electrostatic interactions, and specific solute adsorption. While EHS and Eel are close to 1, Ead>1 in all cases suggesting strong specific interactions between the drugs and the hydrogels. Adsorption was maximal for chlorhexidine on the silicone based hydrogel, in water, due to strong hydrogen bonding. The effective diffusion coefficients, De, were determined from the drug release profiles. Estimations of diffusion coefficients of the non-adsorbed solutes D=De×Ead allowed comparison with theories for solute diffusion in the absence of specific interaction with the polymeric membrane.

  15. Soft contact lenses functionalized with pendant cyclodextrins for controlled drug delivery.

    PubMed

    dos Santos, Jose-Fernando Rosa; Alvarez-Lorenzo, Carmen; Silva, Maite; Balsa, Luis; Couceiro, Jose; Torres-Labandeira, Juan-Jose; Concheiro, Angel

    2009-03-01

    The aim of this work was to develop acrylic hydrogels with high proportions of cyclodextrins maintaining the mechanical properties and the biocompatibility of the starting hydrogels, but notably improving their ability to load drugs and to control their release rate. Poly(hydroxyethylmethacrylate) hydrogels were prepared by copolymerization with glycidyl methacrylate (GMA) at various proportions and then beta-cyclodextrin (betaCD) was grafted to the network by reaction with the glycidyl groups under mild conditions. This led to networks in which the betaCDs form no part of the structural chains but they are hanging on 2-3 ether bonds through the hydroxyl groups. The pendant betaCDs did not modify the light transmittance, glass transition temperature, swelling degree, viscoelasticity, oxygen permeability, or surface contact angle of the hydrogels, but decreased their friction coefficient by 50% and improved diclofenac loading by 1300% and enhanced drug affinity 15-fold. The hydrogels were able to prevent drug leakage to a common conservation liquid for soft contact lenses (SCLs) and to sustain drug delivery in lacrimal fluid for two weeks. To summarize, the hydrogels with pendant betaCDs are particularly useful for the development of cytocompatible medicated implants or biomedical devices, such as drug-loaded SCLs.

  16. Visual and optical performance of silicone hydrogel contact lenses for moderate myopia

    PubMed Central

    Keir, Nancy; Simpson, Trefford; Fonn, Desmond

    2010-01-01

    Purpose To compare the short-term visual and optical performance of silicone hydrogel contact lenses for myopia ≥ −3.00D. Methods This was a short-term, non-dispense, double-masked, randomized study investigating Night&Day (ND), PureVision (PV), O2 Optix (O2), Biofinity (BF), Acuvue Advance (AA) and Acuvue OASYS for myopia ≥ −3.00D. Testing was conducted under scotopic conditions. Measures (one eye only) included: high- and low-contrast visual acuity (HCVA/LCVA), contrast sensitivity, subjective clarity of vision ratings (0-100 scale using reference images, with test image representing grade 50) and ocular aberrations (up to the 4th order, analyzed across individual scotopic pupil sizes). Results Three males and 27 females participated, with a mean (± SD) age of 24.9 ± 7.7 yrs (range 19 to 53 yrs), sphere of −5.30 ± 1.73D (range −3.00 to −10.75D) and cylinder −0.36 ± 0.23D (range 0 to −0.75D). Mean (± SEM) logMAR HCVA ranged from 0.06 (PV) to 0.10 (AA) (± 0.02), LCVA from 0.33 (BF) to 0.40 (AA) (± 0.02) and contrast sensitivity from 2.33 (BF) to 2.53 (ND) (± 0.15) (differences not statistically significant; all p > 0.05). Subjective ratings for the test image ranged from 59 (PV) to 64 (ND) (± 4) and 56 (AA) to 65 (ND) (± 4), for monochromatic and polychromatic reference images, respectively (all p > 0.05). There was a statistically significant impact on ocular aberrations with all study lenses compared to no lens. Between-lens differences were statistically significant for defocus (Z02), horizontal coma (Z 13) and spherical aberration (Z04). Conclusions Despite some differences in ocular aberrations, there were no significant differences in HCVA, LCVA, contrast sensitivity or subjective ratings across lenses.

  17. Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution

    PubMed Central

    Scheuer, Catherine A; Rah, Marjorie J; Reindel, William T

    2016-01-01

    Purpose This study was conducted to determine 1) the concentration of hyaluronan (HA) in the tear films of contact lens (CL) wearers versus non-CL wearers and 2) whether HA sorbed from Biotrue, an HA-containing multipurpose solution (MPS), onto senofilcon A lenses affects the concentration of HA in tears after 2 hours of wear. Patients and methods Tears of habitual CL wearers and non-CL wearers were collected on Schirmer strips at baseline and after 2 hours of wear of senofilcon A CLs that had first been either rinsed with Sensitive Eyes Saline or soaked in Biotrue MPS for 14 hours. HA concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and adjusted for sample volumes. Results No difference in baseline concentrations of HA in tears was found between CL wearers and non-CL wearers (P=0.07), nor between males and females (P=0.06). However, age was significantly negatively associated with HA concentration (P<0.01), and mostly, CL wear contributed to a significant association (P<0.01). Among saline-rinsed CL wearers, no change in HA concentration in tears was observed after 2 hours of wear (P=0.38). By contrast, a significant increase in HA concentration was observed in the tears from eyes that had worn CLs soaked in Biotrue MPS when compared to baseline (P=0.01) or to saline-rinsed control (P=0.03). Conclusion 1) In this study population, no difference in baseline concentration of HA was observed between CL wearers and non-CL wearers, and 2) after 2 hours of wear of senofilcon A lenses that were soaked in Biotrue MPS, HA concentrations in the tear films of CL wearers increased. PMID:27784983

  18. Limited-field radiation for bifocal germinoma

    SciTech Connect

    Lafay-Cousin, Lucie . E-mail: lucie.lafay-cousin@sickkids.ca; Millar, Barbara-Ann; Mabbott, Donald; Spiegler, Brenda; Drake, Jim; Bartels, Ute; Huang, Annie; Bouffet, Eric

    2006-06-01

    Purpose: To report the incidence, characteristics, treatment, and outcomes of bifocal germinomas treated with chemotherapy followed by focal radiation. Methods and Materials: This was a retrospective review. Inclusion criteria included radiologic diagnosis of bifocal germinoma involving the pineal and neurohypophyseal region, no evidence of dissemination on spinal MRI, negative results from cerebrospinal fluid cytologic evaluation, and negative tumor markers. Results: Between 1995 and 2004, 6 patients (5 male, 1 female; median age, 12.8 years) fulfilled the inclusion criteria. All had symptoms of diabetes insipidus at presentation. On MRI, 4 patients had a pineal and suprasellar mass, and 2 had a pineal mass associated with abnormal neurohypophyseal enhancement. All patients received chemotherapy followed by limited-field radiation and achieved complete remission after chemotherapy. The radiation field involved the whole ventricular system (range, 2,400-4,000 cGy) with or without a boost to the primary lesions. All patients remain in complete remission at a median follow-up of 48.1 months (range, 9-73.4 months). Conclusions: This experience suggests that bifocal germinoma can be considered a locoregional rather than a metastatic disease. Chemotherapy and focal radiotherapy might be sufficient to provide excellent outcomes. Staging refinement with new diagnostic tools will likely increase the incidence of the entity.

  19. Efficacy of Detergent and Water Versus Bleach for the Disinfection of Direct Contact Ophthalmic Lenses

    PubMed Central

    Abbey, Ashkan M.; Gregori, Ninel Z.; Surapaneni, Krishna; Miller, Darlene

    2014-01-01

    Purpose While manufacturers recommend cleaning ophthalmic lenses with detergent and water and then a specific disinfectant, disinfectants are rarely used in ophthalmic practices. The aim of this pilot study was to evaluate the efficacy of detergent and water versus bleach, a recommended disinfectant, to eliminate common ocular bacteria and viruses from ophthalmic lenses. Methods Three bacterial strains (Staphylococcus epidermidis, Corynebacterium straitum, and methicillin-resistant Staphylococcus aureus (MRSA) and two viral strains (adenovirus and herpes simplex virus (HSV) type-1) were individually inoculated to 20 gonioscopy and laser lenses. Lenses were washed with detergent and water and then disinfected with 10% bleach. All lenses were cultured after inoculation, after detergent and water, and after the bleach. Bacterial cultures in thioglycollate broth were observed for 3 weeks and viral cultures for 2 weeks. The presence of viruses was also detected by multiplex polymerase chain reaction (PCR). Results All 20 lenses inoculated with Staphylococcus epidermidis, Corynebacterium straitum, adenovirus, and HSV-1 showed growth after inoculation, but no growth after detergent/water and after the bleach. All lenses showed positive HSV and adenovirus PCR after inoculation and negative PCR after detergent/water and after bleach. All MRSA contaminated lenses showed growth after inoculation and no growth after detergent and water. However, one lens showed positive growth after bleach. Conclusions Cleaning with detergent and water appeared to effectively eliminate bacteria and viruses from the surface of contaminated ophthalmic lenses. Further studies are warranted to design practical disinfection protocols that minimize lens damage. PMID:24747806

  20. Clinical performances of two disposable soft contact lenses of different materials on Hong Kong-Chinese.

    PubMed

    Cho, P; Ng, V

    2000-01-01

    Dryness due to contact lens wear and poor wetting of contact lenses among contact lens wearers is a common observation and contact lens manufacturers have introduced new, better quality soft lens materials that are claimed to be more deposit resistant, and/or dehydration resistant. The purpose of this study was to evaluate and compare the clinical performance of Hydron ActiSoft 60 section sign, made of a new material (HyGMAtrade mark) which is claimed to be dehydration resistant with excellent wettability, with ActiFresh 400, made of conventional non-ionic hydrogel material. The experiment was conducted as a double-masked, randomised, cross-over study. Clinical assessment included pre-lens non-invasive tear break up time (PL-NITBUT), logMar visual acuity and contrast sensitivity (CS). Corneal staining, if any, was recorded at each visit. Subjective ratings in regard to dryness, grittiness, lens awareness, vision, comfort, handling (removal), handling (cleaning) and the overall preference of each lens type were obtained at the end of 3 (Phase A) and 6 months' (Phase B) wear. Twenty-eight subjects successfully completed the study. In Phase A, no significant differences were found in both baseline PL-NITBUT and PL-NITBUT after wearing the same lenses for 1 month between the two lens types. In phase B, baseline PL-NITBUT for ActiFresh 400 was significantly shorter than that for ActiSoft 60. However, after 1 month of wear, the difference in PL-NITBUT between the two lens types was no longer significant. PL-NITBUT was significantly reduced after 1 month's wear for both ActiSoft 60 and Actifresh 400, and in both Phase A and Phase B. The two lens types provided comparable logMAR visual acuity, and there was no significant differences in CS (Pelli Robson) between spectacle lens correction (equivalent spheres) and either lens type. The incidence of corneal epithelial staining was significantly higher and more severe with ActiFresh 400 than with ActiSoft 60, both in Phase A

  1. Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect.

    PubMed

    Paradiso, P; Colaço, R; Mata, J L G; Krastev, R; Saramago, B; Serro, A P

    2016-05-18

    In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DMPC + cholesterol (DMPC + CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.

  2. Aqueous salt transport through soft contact lenses: an osmotic-withdrawal mechanism for prevention of adherence.

    PubMed

    Cerretani, Colin; Peng, Cheng-Chun; Chauhan, A; Radke, C J

    2012-12-01

    In addition to improving oxygen permeability, modern silicone-hydrogel (SiHy) soft contact lenses (SCLs) exceed a limiting diffusive ion permeability to aqueous sodium chloride. Below the ion-permeability threshold, siloxane-based SCLs are prone to bind against the corneal epithelium. Salt permeability is argued to reflect indirectly water hydraulic permeability. However, no quantitative explanation is available to date for a threshold salt permeability. We hypothesize that molecular salt diffusion through a SCL supports the postlens tear film (PoLTF) by enhancing water flow into the PoLTF from the cornea. Higher salt concentrations in the PoLTF raise the osmotic pressure there relative to that in the cornea increasing osmotic water withdrawal from the cornea. The proposed osmotic-withdrawal mechanism successfully predicts a self-consistent threshold lens salt permeability when thin-film attractive binding forces are introduced. For the first time, we present a quantitative picture for the possible origin of a threshold salt permeability in SCL manufacture.

  3. AFM in mode Peak Force applied to the study of un-worn contact lenses.

    PubMed

    Torrent-Burgués, J; Sanz, F

    2014-09-01

    Contact lenses (CLs) are of common use and the biocompatibility, topography and mechanical properties of the used materials are of major importance. The objective of this contribution is to apply the AFM in mode Peak Force to obtain surface topography and mechanical characteristics of un-worn CLs of different materials. One material of hydrogel, two of siloxane-hydrogel and one of rigid gas-permeable were used in the study. The results obtained with different materials have been compared, at a nanoscopic level, and the conclusions are diverse. There is no significant influence of the two environments used to measure the characteristics of the CLs, either water or saline solution. The pHEMA hydrogel CL (Polymacon of Soflens) shows the highest values of roughness, adhesion and elastic modulus. The siloxane-hydrogel CL named Asmofilcon A of PremiO presents the lowest values of mean roughness (Ra), root-mean-square roughness (RMS or Rq), adhesion (Adh) and elastic modulus (Ym), meanwhile the siloxane-hydrogel CL named Lotrafilcon B of Air Optix presents the lowest value of skewness (Rsk) and the rigid gas-permeable CL, named RXD, presents the lowest values of kurtosis (Rku) and maximum roughness (Rmax).

  4. In vitro comparison of soaking solutions for rigid gas-permeable contact lenses.

    PubMed

    Chowhan, M A; Asgharian, B; Fontana, F

    1995-01-01

    The comfort of rigid gas-permeable contact lenses is influenced by multiple factors, including the composition of lens material and the presence of surface deposits and/or cleaning solution residues on the lens, as well as the direct effect of lens care solutions on the lens and eye. This study was designed to examine the comparative properties of several soaking solutions with respect to wettability, viscosity, and substantivity, which are essential to maintaining patient comfort. Solutions included in this trial were: OPTI-SOAK Conditioning Solution, Boston Advance Conditioning Solution, Boston Advance Conditioning Solution, Boston Conditioning Solution, Barnes-Hind Wetting and Soaking Solution, Duracare Conditioning, and Total Cleaning, Wetting & Soaking Solution. Wettability, as indicated by mean wetting angle, was determined and OPTI-SOAK Conditioning Solution, followed by Boston Advance and Boston Conditioning solutions, respectively, yielded superior results. For viscosity, OPTI-SOAK Conditioning Solution again provided the most favorable (highest) viscosity, followed by Boston Conditioning and Barnes-Hind solutions. With regard to substantivity, a measure of sustained wettability, Boston Conditioning Solution achieved the highest measurement, followed by OPTI-SOAK and Boston Advance solutions. On the basis of this in vitro evaluation, OPTI-SOAK Conditioning Solution provided the highest potential for patient comfort based on a combination of wettability, viscosity, and substantivity.

  5. AFM in peak force mode applied to worn siloxane-hydrogel contact lenses.

    PubMed

    Abadías, Clara; Serés, Carme; Torrent-Burgués, Juan

    2015-04-01

    The objective of this work is to apply Atomic Force Microscopy in Peak Force mode to obtain topographic characteristics (mean roughness, root-mean-square roughness, skewness and kurtosis) and mechanical characteristics (adhesion, elastic modulus) of Siloxane-Hydrogel Soft Contact Lenses (CLs) of two different materials, Lotrafilcon B of Air Optix (AO) and Asmofilcon A of PremiO (P), after use (worn CLs). Thus, the results obtained with both materials will be compared, as well as the changes produced by the wear at a nanoscopic level. The results show significant changes in the topographic and mechanical characteristics of the CLs, at a nanoscopic level, due to wear. The AO CL show values of the topographic parameters lower than those of the P CL after wear, which correlates with a better comfort qualification given to the former by the wearers. A significant correlation has also been obtained between the adhesion values found after the use of the CLs with tear quality tests, both break-up-time and Schirmer.

  6. A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses.

    PubMed

    Sultan, Pinar; Dogan, Cezmi; Iskeleli, Guzin

    2016-12-01

    The purpose of this study was to investigate the efficacy and safety of the Toris K silicone hydrogel contact lens (SwissLens; Prilly, Switzerland) in keratoconus patients. A database with information on 50 keratoconus patients (64 eyes) fitted with Toris K soft contact lenses over a 2-year period was retrospectively reviewed. Demographic data, prefitting refraction, the reason for choosing the Toris K soft contact lens, uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), best-corrected visual acuity with a rigid gas permeable lens (BCVA RGP), best-corrected visual acuity with the Toris K lens (BCVA Toris K), and complications were evaluated. The mean age ± standard deviation at the time of fitting was 27.92 ± 9.86 years. The mean spherical refractive power was -4.62 ± 6.53 dioptres, and the mean cylinder was -3.78 ± 2.43 dioptres. The most common reason for using Toris K soft contact lenses was an inability to fit the patient with a RGP contact lens. There was a statistically significant difference between UCVA and BCVA Toris K (p = 0.0001), as well as between BSCVA and BCVA Toris K (p = 0.0001). However, there was no statistically significant difference between BCVA Toris K and BCVA RGP (p = 0.20). Superficial punctate keratitis and giant papillary conjunctivitis were the most common complications. The Toris K contact lens is a viable alternative for the optical management of all grades of keratoconus. The Toris K soft contact lens is a promising alternative for the visual rehabilitation of keratoconus patients who cannot tolerate RGP lenses or achieve a good fit.

  7. Effect of plasma treatment on the performance of two drug-loaded hydrogel formulations for therapeutic contact lenses.

    PubMed

    Paradiso, Patrizia; Chu, Virginia; Santos, Luís; Serro, Ana Paula; Colaço, Rogério; Saramago, Benilde

    2015-07-01

    Although the plasma technology has long been applied to treat contact lenses, the effect of this treatment on the performance of drug-loaded contact lenses is still unclear. The objective of this work is to study the effect of nitrogen plasma treatment on two drug-loaded polymeric formulations which previously demonstrated to be suitable for therapeutic contact lenses: a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel loaded with levofloxacin and a silicone-based hydrogel loaded with chlorhexidine. Modifications of the surface and the optical properties, and alterations in the drug release profiles and possible losses of the antimicrobial activities of the drugs induced by the plasma treatment were assessed. The results showed that, depending on the system and on the processing conditions, the plasma treatment may be beneficial for increasing wettability and refractive index, without degrading the lens surface. From the point of view of drug delivery, plasma irradiation at moderate power (200 W) decreased the initial release rate and the amount of released drug, maintaining the drug activity. For lower (100 W) and higher powers (300 W), almost no effect was detected because the treatment was, respectively, too soft and too aggressive for the lens materials.

  8. Effects of operational conditions on the supercritical solvent impregnation of acetazolamide in Balafilcon A commercial contact lenses.

    PubMed

    Braga, Mara E M; Costa, Viviana P; Pereira, Mário J T; Fiadeiro, Paulo T; Gomes, Ana Paula A R; Duarte, Catarina M M; de Sousa, Hermínio C

    2011-11-28

    In this work we employed a supercritical solvent impregnation (SSI) process using a scCO(2)+EtOH (5% molar) solvent mixture to impregnate acetazolamide (ACZ) into commercially available silicone-based soft contact lenses (Balafilcon A, Pure Vision, Bausch & Lomb). Contact lenses (SCLs) drug-loading was studied at 40°C and 50°C, and from 15 MPa up to 20 MPa, and using low depressurization rates in order to avoid any harm to SCLs. The effect of impregnation processing time on the loaded ACZ amounts was also studied (1, 2 and 3h). In vitro drug release kinetics studies were performed and the released ACZ was quantified spectrophotometrically. Several analytical techniques were employed in order to characterize the processed and non-processed SCLs in terms of some of their important functional properties. Obtained results demonstrated that ACZ-loaded therapeutic Balafilcon A SCLs can be successfully prepared using the employed SSI process. Furthermore, it was possible to control ACZ loaded amounts and, consequently, to adjust the final ACZ release levels into the desired therapeutic limits, just by changing the employed operational conditions (P, T, processing time and depressurization rate) and without change some of their most important thermomechanical, surface/wettability and optical properties. Obtained soft contact lenses can be potentially employed as combined biomedical devices for simultaneous therapeutic and correction of refractive deficiencies purposes.

  9. Adhesive Capabilities of Staphylococcus Aureus and Pseudomonas Aeruginosa Isolated from Tears of HIV/AIDS Patients to Soft Contact Lenses

    PubMed Central

    B. O., Ajayi; F.E., Kio; F.D., Otajevwo

    2012-01-01

    Fifty conjunctival swab samples collected from ELISA confirmed HIV/AIDS seropositive patients who were referred to the HIV/AIDS laboratories of the University of Benin Teaching Hospital and Central Hospital both based in Benin City, Nigeria were aseptically cultured on appropriate media by standard methods. The resulting isolates/strains, after identification by standard methods, were tested for their ability to adhere to two hydrophobic non-ionic daily wear silicone hydrogel soft contact lenses (i.e. lotrafilcon B, WC 33% and polymacon, WC 38%) as well as to two hydrophilic ionic conventional extended wear silicone hydrogel soft contact lenses (i.e. methafilcon A, WC 55% and omafilcon A, WC 60%) by the adhesiveness/slime production modified vortex/Robin device method. Evidence of adhesiveness/slime production was indicated by presence of a visible stained film lining the surface of the contact lens which was measured and recorded as strong or weak according to the density of the adhered bacterial film. Fourteen (28.0%) Staphylococcus aureus strains and 10 (20.0%) Pseudomonas aeruginosa strains were obtained among other organisms. Staphylococcus aureus strains adhered in decreasing order to lotrafilcon B (55.4 ± 4.7), polymacon (46.4 ± 8.4), methfilcon A (46.4 ± 8.4) and omafilcon A (25.0 ± 6.4) with no significant difference in adhesive strengths of individual strains (P > 0.05). Pseudomonas aeruginosa strains also recorded decreasing adhesive strengths to lotrafilcon B (37.5 ± 8.2), polymacon (28.6 ± 6.3), methafilcon A (26.8 ± 5.5) and omafilcon A (23.2 ± 5.5) also with no significant difference in adhesive strengths of individual strains (P > 0.05). Attachment strengths of Staph. aureus strains to all four contact lenses were higher than those of Pseudomonas aeruginosa strains. Both organisms adhered most to hydrophobic lotrafilcon B and least to hydrophilic omafilcon A. This invitro adhesion studies revealed that daily wear silicone hydrogel low water

  10. Optics of progressive addition lenses.

    PubMed

    Sheedy, J E; Buri, M; Bailey, I L; Azus, J; Borish, I M

    1987-02-01

    The optical characteristics of the major progressive addition lenses were measured using an automated lensometer with a specially designed lens holder to simulate eye rotation. Measurements were made every 3 degrees (about 1.5 mm) and graphs of isospherical equivalent lines and isocylinder lines were developed. Generally the near zone of these lenses is narrower and lower than in bifocal or trifocal lenses. Distinct differences exist between the various progressive lenses. The width of the near zone, rate of power progression, amount of unwanted cylinder (level with the distance center), and clarity of the distance zone are compared for the various lenses. The optical measurements demonstrate an apparent trade-off between the size of the cylinder-free area of the lens and the amount of the cylinder.

  11. Acanthamoeba spp. in Contact Lenses from Healthy Individuals from Madrid, Spain

    PubMed Central

    Gomes, Thiago dos Santos; Magnet, Angela; Izquierdo, Fernando; Vaccaro, Lucianna; Redondo, Fernando; Bueno, Sara; Sánchez, Maria Luisa; Angulo, Santiago; Fenoy, Soledad; Hurtado, Carolina; del Aguila, Carmen

    2016-01-01

    Purpose Acanthamoeba keratitis (AK) is a painful and potentially blinding corneal infection caused by Acanthamoeba spp. In Madrid, environmental studies have demonstrated a high presence of these free-living amoebae in tap water. Since most of AK cases occur in contact lenses (CL) wearers with inadequate hygiene habits, the presence of Acanthamoeba in discarded CL has been studied and compared with other common etiological agents of keratitis, such as Pseudomonas aeruginosa and Staphylococcus aureus. Methods One hundred and seventy-seven healthy individuals from Madrid contributed their discarded CL and answered a questionnaire on hygiene habits. DNA was extracted from the CL solution and analyzed by real-time PCR for Acanthamoeba, Pseudomonas aeruginosa and Staphylococcus aureus. These CL and their solutions were also cultured on non-nutrient agar to isolate Acanthamoeba. Results Among the 177 samples, Acanthamoeba DNA was detected in 87 (49.2%), P. aeruginosa DNA in 14 (7.9%) and S. aureus DNA in 19 (10.7%). Cultivable amoebae, however, were observed in only one sample (0.6%). This isolate was genotyped as T4. The habits reported by this CL owner included some recognized risk factors for AK, but in this study only the practice of “not cleaning the CL case” presented some statistical significant association with Acanthamoeba DNA presence. Detection of the investigated bacterial DNA did not demonstrate statistical significant association with the studied practices, but the presence of P. aeruginosa revealed a possible inhibition of Acanthamoeba in these samples. Conclusions The PCR results suggest a high presence of Acanthamoeba spp. in healthy CL wearers from Madrid, but we can assume that CL solutions are properly disinfecting the CL since only 1.1% of the positive PCR samples correspond to viable amoebae and, after four years, only one participant reported stronger ocular problems. Nevertheless, more studies are necessary to corroborate this hypothesis. PMID

  12. [The search for electrophysiological predictors of visual comfort after presbyopia correction with contact lenses].

    PubMed

    El Ameen, A; Majzoub, S; Pisella, P-J

    2017-03-24

    Starting at 40 years of age, prespyopia affects a quarter of the world population. Many techniques of presbyopia surgery have emerged in recent years. The purpose of this study was to compare monovision and multifocality and to identify clinical and electrophysiological predictive markers of visual comfort for each correction available in clinical practice. Ten presbyopic patients participated in this study. Patients received monovision and multifocal correction using contact lenses for three weeks each in a random order. A clinical evaluation (visual acuity, TNO test, binocular contrast sensitivity and quality of vision questionnaires) and an electrophysiological evaluation (monocular and binocular pattern VEP with multiple spatial frequencies: 60, 30 and 15') were performed before and after each correction modality. The P100 was significantly wider and slightly earlier after binocular compared to monocular stimulation at T0. The TNO stereopsis score decreased significantly after correction. No other significant differences, either on clinical or electrophysiological criteria, were found between the two modes of correction. Several significant correlations were found between the stereoacuity difference depending upon correction and evoked potentials by binocular pattern at T0. The larger the stereoacuity difference (better stereoacuity with multifocal compensation), the longer the latency of the P100 using 60' checks (R=0.82; P=0.004) and the greater the amplitude of the N75 using 30' (R=0.652; P=0.04). Our study found no differences between the 2 types of correction, but it highlights a benefit of VEP used in current practice and measurement of the P100 wave, the best indicator of stereopsis and the most consistent, to predict visual comfort after compensation presbyopia.

  13. Bandage soft contact lenses for ocular graft-versus-host disease

    PubMed Central

    Inamoto, Yoshihiro; Sun, Yi-Chen; Flowers, Mary E. D.; Carpenter, Paul A.; Martin, Paul J.; Li, Peng; Wang, Ruikang; Chai, Xiaoyu; Storer, Barry E.; Shen, Tueng T.; Lee, Stephanie J.

    2015-01-01

    To examine safety and efficacy of bandage soft contact lenses (BSCLs) for ocular chronic graft-versus host disease (GVHD), we conducted a phase II clinical trial. Extended-wear BSCLs were applied under daily topical antibiotics prophylaxis. Patients completed standardized symptom questionnaires at enrollment and at 2 weeks, 4 weeks and 3 months afterwards. Ophthalmologic assessment was performed at enrollment, at 2 weeks and afterwards as medically needed. Assessments at follow-up were compared with baseline by paired t-test. Nineteen patients with ocular GVHD who remained symptomatic despite conventional treatments were studied. The mean Lee eye subscale score was 75.4 at enrollment, and improved significantly to 63.2 at 2 weeks (p=0.01), to 61.8 at 4 weeks (p=0.005) and to 56.3 at 3 months (p=0.02). The ocular surface disease index score and 11-point eye symptom ratings also improved significantly. According to the Lee eye subscale, clinically meaningful improvement was observed in 9 patients (47%) at 2 weeks, in 11 (58%) at 4 weeks and in 9 (47%) at 3 months. Visual acuity improved significantly at 2 weeks compared with enrollment values. Based on slit lamp exam at 2 weeks, punctate epithelial erosions improved in 58% of the patients, showed stability in 16% and worsened in 5%. No corneal ulceration or ocular infection occurred. BSCLs are a widely available, safe and effective treatment option that improves manifestations of ocular graft-versus host disease in approximately 50% of patients. This study was registered at www.clinicaltrials.gov as NCT01616056. PMID:26189353

  14. Microbial contamination of contact lenses after scaling and root planing using ultrasonic scalers with and without protective eyewear: A clinical and microbiological study

    PubMed Central

    Afzha, Rooh; Chatterjee, Anirban; Subbaiah, Shobha Krishna; Pradeep, Avani Rangaraju

    2016-01-01

    Background: Ultrasonic scaler is a preferential treatment modality among the clinicians. However, the aerosol/splatter generated is a concern for patients and practitioners. Therefore, the purpose of this study was to evaluate contamination of contact lenses of the dentist after scaling and root planing using ultrasonic scalers with and without protective eyewear. Materials and Methods: Thirty patients were randomly selected for scaling and root planing and divided into 2 groups of 15 each. Group A – dentist wearing contact lenses and protective eyewear. Group B - dentist wearing only contact lenses. After scaling and root planing using ultrasonic scalers, the lenses were subjected to culture and 16S rRNA (16S ribosomal RNA) gene sequencing. Results: In Group A – 15 out of thirty samples were contaminated, in Group B – all the thirty samples were contaminated. Most of the samples showed Gram-positive bacteria and 5 samples were contaminated with fungi. 16S rRNA gene sequencing of forty contaminated samples showed that 31 were contaminated with Streptococcus mutans and 9 with Staphylococcus aureus. Conclusion: Keeping in mind the limitation of the study for the absence of negative control, we would like to conclude that dental practitioners should better avoid contact lenses in a dental setup because of the risk of contamination of the contact lenses from the various dental procedures which can produce aerosol/splatter and if worn, it is recommended to wear protective eyewear. PMID:27563200

  15. Twin axial vortices generated by Fibonacci lenses.

    PubMed

    Calatayud, Arnau; Ferrando, Vicente; Remón, Laura; Furlan, Walter D; Monsoriu, Juan A

    2013-04-22

    Optical vortex beams, generated by Diffractive Optical Elements (DOEs), are capable of creating optical traps and other multi-functional micromanipulators for very specific tasks in the microscopic scale. Using the Fibonacci sequence, we have discovered a new family of DOEs that inherently behave as bifocal vortex lenses, and where the ratio of the two focal distances approaches the golden mean. The disctintive optical properties of these Fibonacci vortex lenses are experimentally demonstrated. We believe that the versatility and potential scalability of these lenses may allow for new applications in micro and nanophotonics.

  16. Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: In vitro and in vivo evaluation.

    PubMed

    Maulvi, Furqan A; Shaikh, Anjum A; Lakdawala, Dhara H; Desai, Ankita R; Pandya, Mihir M; Singhania, Sulabh S; Vaidya, Rutvi J; Ranch, Ketan M; Vyas, Bhavin A; Shah, Dinesh O

    2017-01-25

    Contact lenses are widely used for ophthalmic drug delivery, but incorporation of drug or formulation in the contact lenses affects its optical and physical property. In the present study, we have designed a novel hyaluronic acid (HA)-laden ring implant contact lenses (modified cast moulding method), to circumvent the changes in critical lens property. The objective was to improve the ocular residence time of HA, by providing sustained ocular HA delivery through implant contact lenses for the treatment of dry eye syndrome. Optimization of HA-implant was carried out using 3(2) factorial design by tailoring the amount of cross linker and thickness of implant, to achieve sustained HA release with constraint on effective ion diffusivity. The in vivo pharmacokinetic study in rabbit tear fluid showed sustained HA release up to 15days, by fabricating implant (80μgHA loading) with 78.4μm thickness (total thickness of lens=100μm) using 0.925% of cross linker, with effective ion diffusivity>1.5×10(-6)mm(2)/min. In vivo efficacy study in benzalkonium chloride induced dry eye syndrome rabbits showed faster healing with implant contact lenses in comparison to positive control group. The study demonstrated the promising potential of implantation technology to deliver hyaluronic acid without compromising optical and physical properties of contact lens.

  17. A relatively small change in sodium chloride concentration has a strong effect on adhesion of ocular bacteria to contact lenses.

    PubMed

    Cowell, B A; Willcox, M D; Schneider, R P

    1998-06-01

    Adhesion of bacteria to hydrogel lenses is thought to be an initial step of ocular colonization allowing evasion of normal host defences. The salt concentration of media is an important parameter controlling microbial adhesion. Salinity varies from 0.97% NaCl equivalents in the open eye to 0.89% in the closed eye state. In this study, the effect of sodium chloride in the concentration range of 0.8-1.0% (w/v) NaCl on adhesion of ocular bacteria to soft contact lenses was investigated using a static adhesion assay. Pseudomonas aeruginosa was found to adhere to lenses in significantly greater amounts than Serratia marcescens, Flavobacterium meningosepticum, Stenotrophomonas maltophilia and Staphylococcus intermedius. Increasing NaCl from 0.8% to 1.0% (w/v) increased adhesion of all bacteria tested. This adhesion was strong since the organisms could not be removed by washing in low ionic buffer. Adhesion of these organisms did not correlate with their cell surface properties as determined by bacterial adhesion to hydrocarbons (BATH) and retention on sepharose columns.

  18. An Operational Evaluation of Extended-Wear Soft Contact Lenses in an Armored Division.

    DTIC Science & Technology

    1987-08-01

    blepharitis and coated lenses. 1...- Suspension and attrition In accordance with accepted clinical practice and the terms of the approved research protocol...conjunctivitis 6 0 Neovascularization (>2mm) 3 3 Decreased visual acuity (>7 days duration) 2 0 Blepharitis 1 0 Corneal staining 1 0 Corneal stromal infiltrates 0...Phlyetenule-- -- --- - - Corneal stromal infilt -- ---------- Blepharitis -- --- -- - -- - - Corneal ulcer-- ----- -- 1691 % V SS -U Si’..~ 4

  19. Corneal deswelling following overnight wear of rigid and hydrogel contact lenses.

    PubMed

    Holden, B A; Sweeney, D F; La Hood, D; Kenyon, E

    1988-01-01

    The edema response over a 24-hour sleep/wake cycle of ten subjects wearing a rigid gas-permeable (RGP) lens in one eye and a hydrogel lens in the other was evaluated. Lenses that result in equivalent amounts of overnight edema were selected. There was no significant difference in the rates of deswelling during the initial hour. However, at three and five hours after eye opening, the amount of residual edema was greater in the eye wearing the hydrogel lens. We suggest that when an RGP lens provides the same closed-eye level of oxygen as a hydrogel lens, the greater tear exchange of the RGP lens will result in a greater open-eye oxygen supply, leading to less daytime edema. This suggests that the more complete deswelling we observed with RGP lenses can be attributed to a lower stimulus to open-eye swelling. Biomicroscopy, subjective vision, and patient comfort were also rated on waking and ten hours after eye opening. On eye opening there was significantly more back-surface debris (P = 0.01) with the RGP lenses. Patients wearing RGPs rated comfort as poorer and vision as better but only the latter attained statistical significance.

  20. Identification by means of low-field nuclear magnetic resonance of the chemical-physical characteristics of multidose artificial tear solutions in interaction with hydrogel model contact lenses.

    PubMed

    Pescosolido, Nicola; Casciani, Lorena

    2007-12-01

    In this paper, the chemical-physical interactions between two commercially available ophthalmic solutions and hydrogel contact lenses classified according to the four Food and Drug Administration groups were studied by measuring transversal relaxation times (T(2)) of water molecules by low-field nuclear magnetic resonance techniques. The aim was to evaluate possible modifications to the contact lens structure, with particular emphasis on their hydration mechanism. No significant variations in the T(2) values were observed when the T(2) values of the first component of samples swollen with saline solution as the reference were compared with samples of the same set of lenses swollen in the two commercially available ophthalmic solutions. We can, therefore, assume that the hydration characteristics remained unchanged in all the samples studied, and that the experimental ophthalmic solutions ensured an adequate hydration of the sample hydrogel contact lenses without any negative effects on the structure of their polymer chains.

  1. Physical human model eye and methods of its use to analyse optical performance of soft contact lenses.

    PubMed

    Bakaraju, Ravi C; Ehrmann, Klaus; Falk, Darrin; Ho, Arthur; Papas, Eric

    2010-08-02

    A bench-top physical model eye that closely replicates both anatomical and optical properties of an average human eye was designed and constructed. The cornea was sourced from a flouro-polymer with refractive index (RI) of 1.376 and crystalline lenses were made of Boston RGP polymers, EO and Equalens II, with an equivalent RI of 1.429 and 1.423 respectively. These materials served to make crystalline lens components of different age groups and accommodative states. De-Ionized water, with RI of 1.334 represented both aqueous and vitreous humor. The complementary metal-oxide sensor of a PixelLink digital camera with a resolution of 5MP and a 2.2 microm pixel pitch, hosted on a motor-base, served as the 'acting' retina. The translation and rotary functions of the motor-base facilitated the simulation of different states of ametropia and assessment of peripheral visual function, respectively. We validated one of its configurations to suit normal viewing conditions and results from the on and off-axis optical quality measurements are presented. As a demonstration of potential practical uses, several corrective soft contact lenses were placed on the model eye and their optical performance evaluated.

  2. [Study of the surface tear tension and evaluation of its importance for the retinal physiology and pathology in contact correction and in adaptation to soft contact lenses].

    PubMed

    Cherepnin, A I; Smoliakova, G P; Sorokin, E L

    2003-01-01

    The surface lachrymal-fluid (LF) tension was investigated by teardrop dissection in 115 patients with myopia before they were prescribed soft contact lenses (SCL). Such tension was found to be of clinical importance for the development of SCL adaptation disorders. A longer adaptation period in patients with myopia was associated with a low surface LF tension. A high surface LF tension concurrent with the teardrop dissection mode of the destruction type was typical of the pathological nature of SCL adaptation (12.1% of patients). The obtained data are needed to detect timely the risk of dysadaptation disorders and corneal complications before SCL prescription for the purpose of undertaking the pathogenetically substantiated medication to prevent such complications.

  3. Structural study of polymer hydrogel contact lenses by means of positron annihilation lifetime spectroscopy and UV-vis-NIR methods.

    PubMed

    Filipecki, J; Kocela, A; Korzekwa, P; Miedzinski, R; Filipecka, K; Golis, E; Korzekwa, W

    2013-08-01

    A study has been conducted in order to determine presence of free volume gaps in the structure of structure of polymer hydrogel contact lenses made in phosphoryl choline technology and of the degree of defect of its structure. The study was made by means of positron annihilation lifetime spectroscopy. As a result of the conducted measurements, curves were obtained, which described numbers of counts of the acts of annihilation in the time function. The conducted studies revealed existence of three components τ(1), τ(2) and τ(3). The τ(3) component is attributed to the pick-off annihilation of o-Ps orthopositronium trapping by free volume gaps and provides information about geometrical parameters of the volumes. At the same time, the UV-vis-NIR spectrometry examination was conducted on the same samples in the spectral range 200-1,000 nm.

  4. Interferometric control of contact line, shape, and aberrations of liquid lenses

    NASA Astrophysics Data System (ADS)

    Voitenko, Igor; Storm, Ronald; Westfall, Raymond; Rogers, Stanley

    2007-09-01

    An optical system consisting of an aqueous electrolyte resting on a polymer/gold/indium-tin-oxide (ITO) layer deposited onto a glass substrate is analyzed to acquire contact angle - focal distance data as a function of applied voltage. The shape factor of a liquid lens and its dependence on the perimeter of contact line and contact angle was analyzed in the presence of an electrical field applied between the electrolyte and planar electrode system. The contact angle of a liquid on a thin, transparent film of gold (20 nm thick) - on ITO under electrolyte solution could be varied from 110 +/- 3° when the gold was held at -2.4 V to 41 +/- 3° without voltage. The behavior of a water-based electrolyte and water-soluble polymer blend and its influence on the shape of contact line and profile of the lens were investigated by employing a holographic setup at wavelengths of 632.8 and 543.5 nm. Optical micrographs showing the profile of the lens, aberration-less aperture, deformation of contact line, and shape of the liquid lens, respectively, were analyzed in reflection and transmission. Both the advancing and receding contact angles were measured directly from digitized images of the profile of the lens. The dynamic range of linear beam steering and dependence of the focal length of the liquid lens on the applied voltage are discussed.

  5. Racial Variations in Interfacial Behavior of Lipids Extracted from Worn Soft Contact Lenses

    PubMed Central

    Svitova, Tatyana F.; Lin, Meng C.

    2014-01-01

    Purpose To explore interfacial behaviors and effect of temperature and dilatation on dynamic properties of multilayered human tear lipids extracted from silicone hydrogel (SiH) lenses worn by asymptomatic Asian and Caucasian subjects. Methods Interfacial properties of lipids extracted from Focus® N&D lenses worn by 14 subjects continuously for 1 month were studied. The lipids were deposited on an air bubble immersed in a model tear electrolytes (MTE) solution to form 100 ± 20 nm-thick films. Surface pressure was recorded during slow expansion/contraction cycles to evaluate compressibility and hysteresis of lipid films. Films were also subjected to fast step-strain dilatations at temperatures 22°–45° C for their visco-elastic properties assessment. Results Iso-cycles for Asian and Caucasian lipids were similar at low surface pressures, but had distinctly different compressibility and hysteresis at dynamic pressures exceeding 30 mN/m. Rheological parameters of reconstituted lipids were also dissimilar between Asian and Caucasian. The elastic modulusE∞ for Caucasian lipids was 1.5 times higher than that for Asian lipids, whereas relaxation time (t) was on average 1.3 times higher for Asian. No significant changes were observed in rheological properties of both Asian and Caucasian lipids when temperature increased from 22.0° to 36.5° C. However, for Caucasian lipids, E∞ reduced considerably at temperatures above 42.0° C, while t remained unchanged. For Asian lipids, both E∞ and t started to decline as temperature increased to 38° C and higher. Conclusions Higher elastic modulus of Caucasian lipids and elasticity threshold at certain deformations indicate stronger structure and intermolecular interactions as compared with more viscous Asian lipids. The differences in interfacial behaviors between Asian and Caucasian lipids may be associated with the differences in their chemical compositions. PMID:24270592

  6. Tear Osmolarity and Dry Eye Symptoms in Women Using Oral Contraception and Contact Lenses

    PubMed Central

    Chen, Sarah P.; Massaro-Giordano, Giacomina; Pistilli, Maxwell; Schreiber, Courtney A.; Bunya, Vatinee Y.

    2013-01-01

    Purpose To examine the relationship between oral contraceptive pill (OCP) use, contact lens wear, and dry eye signs and symptoms in healthy young females. Methods Fifty-two women using OCPs and forty-five women not using any form of hormonal contraception were enrolled. Medical, menstrual, and contact lens histories were obtained and dry eye symptoms were assessed using the Ocular Surface Disease Index (OSDI) and Symptom Assessment iN Dry Eye (SANDE) questionnaires. Tear osmolarity testing was performed using the TearLab™ Osmolarity System. Results Mean age of all subjects was 26.0 ± 3.7 years. There were no significant differences in any of the measurements between the follicular and luteal phases. While SANDE scores were significantly higher in subjects with OCP and recent contact lens use (p<0.01), there were no significant differences in OSDI and tear osmolarity amongst the same subject groups. Subjects who reported both OCP and recent contact lens use had significantly higher OSDI and SANDE scores (p=0.015 and p<0.001, respectively). Conclusions There were no differences between the phases of the menstrual cycle. Tear osmolarity was not affected by OCP or contact lens use in young females. However, the combination of OCP use and contact lens wear may increase the severity of dry eye symptoms. PMID:23086364

  7. Characterization of protein adsorption on soft contact lenses. IV. Comparison of in vivo spoilage with the in vitro adsorption of tear proteins.

    PubMed

    Castillo, E J; Koenig, J L; Anderson, J M

    1986-03-01

    Tear protein and gamma-globulin mixtures were adsorbed on soft contact lenses of different chemical composition, surface quality and water content. The adsorption process was followed by Fourier transform infrared-attenuated total reflectance spectroscopy (ATR-FTIR). It was found that gamma-globulin underwent a conformational and orientational change after its adsorption and the extent of structural change appeared to be proportional to the binding strength of the protein with the hydrogel surface. Electrostatic interactions play a major role in the protein adsorption on lenses containing methacrylic acid. Lysozyme is selectively adsorbed on all of the high water content hydrogels and mucin is the major protein component for the pure PHEMA type of lenses. Studies on in vivo spoiled PHEMA and PVP/MMA lenses indicate that lysozyme is the major adsorbed deposit. Papain cleaning of in vivo spoiled lenses shows that although a portion of the deposits is desorbed, the enzyme itself becomes irreversibly adsorbed to the contact lens which may cause harmful effects to the eye.

  8. How to prevent and treat anysometropic-amblyopic child by contact lenses.

    PubMed

    Salopek-Rabatić, Jasminka; Pavan, Josip; Kastelan, Snjezana; Rabatić, Leon

    2013-04-01

    Anisometropy as a first step on a way forward future amblyopic child, can be prevent and treat if this condition is recognased on time. Second step is wisdom, right contact lens fit on bothes eyes. As follow, some ortoptic-pleoptic procedures depending on (objective, subjective squinting angle, state of fusion, visus on bothes eyes and separatly each eay and condition of nervus opticus (VEP), normal or absent retinal corespondence, are recomended. There is no limit how old a child is, but best choice and best compliance is age between five and twelve. Contact lens materiales, different fit procedures, right diagnosys and tips all about are discussed.

  9. Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications.

    PubMed

    García-Millán, Eva; Koprivnik, Sandra; Otero-Espinar, Francisco Javier

    2015-06-20

    This paper proposes an approach to improve drug loading capacity and release properties of poly(2-hydroxyethyl methacrylate) (p(HEMA)) soft contact lenses based on the optimization of the hydrogel composition and microstructural modifications using water during the polymerization process. P(HEMA) based soft contact lenses were prepared by thermal or photopolymerization of 2-hydroxyethyl methacrylate (HEMA) solutions containing ethylene glycol di-methacrylate as crosslinker and different proportions of N-vinyl-2-pyrrolidone (NVP) or methacrylic acid (MA) as co-monomers. Transmittance, water uptake, swelling, microstructure, drug absorption isotherms and in vitro release were characterized using triamcinolone acetonide (TA) as model drug. Best drug loading ratios were obtained with lenses containing the highest amount (200 mM) of MA. Incorporation of 40% V/V of water during the polymerization increases the hydrogel porosity giving a better drug loading capacity. In vitro TA release kinetics shows that MA hydrogels released the drug significantly faster than NVP-hydrogels. Drug release was found to be diffusion controlled and kinetics was shown to be reproducible after consecutive drug loading/release processes. Results of p(HEMA) based soft contact lenses copolymerized with ethylene glycol dimethacrylate (EGDMA) and different co-monomers could be a good alternative to optimize the loading and ocular drug delivery of this corticosteroid drug.

  10. Exploration and comparison of in vitro eye irritation tests with the ISO standard in vivo rabbit test for the evaluation of the ocular irritancy of contact lenses.

    PubMed

    Yun, Jun-Won; Hailian, Quan; Na, Yirang; Kang, Byeong-Cheol; Yoon, Jung-Hee; Cho, Eun-Young; Lee, Miri; Kim, Da-Eun; Bae, SeungJin; Seok, Seung Hyeok; Lim, Kyung-Min

    2016-12-01

    In an effort to explore the use of alternative methods to animal testing for the evaluation of the ocular irritancy of medical devices, we evaluated representative contact lenses with the bovine corneal opacity and permeability test (BCOP) and an in vitro eye irritation test using the three-dimensionally-reconstructed human corneal epithelium (RhCE) models, EpiOcular™ and MCTT HCE™. In addition, we compared the obtained results with the ISO standard in vivo rabbit eye irritation test (ISO10993-10). Along with the positive controls (benzalkonium chloride, BAK, 0.02, 0.2, and 1%), the extracts of 4 representative contact lenses (soft, disposable, hard, and colored lenses) and 2 reference lenses (dye-eluting and BAK-coated lenses) were tested. All the lenses, except for the BAK-coated lens, were determined non-irritants in all test methods, while the positive controls yielded relevant results. More importantly, BCOP, EpiOcular™, and MCTT HCE™ yielded a consistent decision for all the tested samples, with the exception of 0.2% BAK in BCOP, for which no prediction could be made. Overall, all the in vitro tests correlated well with the in vivo rabbit eye irritation test, and furthermore, the combination of in vitro tests as a tiered testing strategy was able to produce results similar to those seen in vivo. These observations suggest that such methods can be used as alternative assays to replace the conventional in vivo test method in the evaluation of the ocular irritancy of ophthalmic medical devices, although further study is necessary.

  11. Tear Film Surface Quality with Soft Contact Lenses Using Dynamic Videokeratoscopy

    PubMed Central

    Kopf, Miriam; Yi, Fan; Robert Iskander, D.; Collins, Michael J.; Shaw, Alyra J.; Straker, Benjamin

    2010-01-01

    Purpose To investigate changes in tear film surface quality after commencing soft contact lens wear. Methods Tear film surface quality (TSQ) was assessed during the interblink period using dynamic videokeratoscopy at 25 Hz. A quantitative value of TSQ is derived for each raw Placido ring image. Eleven young subjects with normal tear characteristics participated in the study. Dynamic videokeratoscopy was taken three times per day; in the morning, at lunchtime, and in the afternoon. This was done on two baseline days (bare eye) and on the first and seventh days of lens wear for a conventional hydrogel lens and following a week of no lens wear, for a further week of silicone hydrogel lens wear. Additionally clinical tests to assess TSQ were conducted and subjects were also asked to rate the subjective dryness of their eyes. Results All lens wear measurements showed a significant worsening of TSQ compared to bare eye measurements (repeated measures ANOVA, P<0.01). A significant diurnal change was found on the first day of silicone hydrogel contact lens wear, where TSQ improved during the day (P=0.045). However, no diurnal changes were found in TSQ for the other lens wearing days or for the bare eye condition (P>0.05). The subjective rating of dryness correlated with TSQ values (Pearson's r=0.62, P<0.05) for the bare eye condition, but not during contact lens wear. TSQ derived from the right and left bare eyes of the same individuals showed a significant correlation (Pearson's r=0.61, P<0.05). Conclusions The measurement of TSQ using dynamic videokeratoscopy differentiates between bare eye and lens wearing conditions. It also shows a small systematic improvement in tear surface quality during the first day of silicone hydrogel lens wear and a significant association with subjective dryness for the bare eye condition.

  12. Contact lens in keratoconus

    PubMed Central

    Rathi, Varsha M; Mandathara, Preeji S; Dumpati, Srikanth

    2013-01-01

    Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP) lenses, soft and soft toric lenses, piggy back contact lenses (PBCL), hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the English language with the keywords keratoconus and various contact lenses such as Rose k lens, RGP lens, hybrid lens, scleral lens and PBCL. PMID:23925325

  13. Nonadhesive, silica nanoparticles-based brush-coated contact lens cases--compromising between ease of cleaning and microbial transmission to contact lenses.

    PubMed

    Qu, Wenwen; Hooymans, Johanna M M; Qiu, Jun; de-Bont, Nik; Gelling, Onko-Jan; van der Mei, Henny C; Busscher, Henk J

    2013-05-01

    Surface properties of lens cases are determinant for their cleanability and for microbial transmission from lens cases to contact lenses (CLs). PEG-polymer-brush-coatings are known to decrease microbial adhesion more than other surface-coatings. Here, we applied a robust, silica nanoparticles-based brush-coating to polypropylene cases to evaluate their ease of cleaning and probability of bacterial transmission to CLs. Adhesion forces of nine bacterial strains (Pseudomonas, Staphylococci, and Serratia) to rigid CLs, polypropylene, and silica nanoparticles-based brush-coated polypropylene were measured using atomic-force-microscopy and subjected to Weibull analyses to yield bacterial transmission probabilities. Biofilms of each strain were grown in coated and uncoated cases and rinsed with a NaCl or antimicrobial lens care solution. Residual, viable organisms were quantified. Bacterial adhesion forces of all strains were significantly, up to tenfold smaller on brush-coated than on uncoated polypropylene. This yielded, higher transmission probabilities to a CL, but mild-rinsing yielded 10-100 fold higher removal of bacteria from brush-coated than from polypropylene cases. Moreover, due to weak adhesion forces, bacteria on brush-coated cases were two-to-three fold more susceptible to an antimicrobial lens care solution than on polypropylene cases. Therewith, the design of lens case surfaces is a compromise between ease of cleaning and transmission probability to CLs.

  14. Zero-Order Antibiotic Release from Multilayer Contact Lenses: Nonuniform Drug and Diffusivity Distributions Produce Constant-Rate Drug Delivery.

    PubMed

    Guzman, Gustavo; Es-Haghi, Siamak Shams; Nugay, Turgut; Cakmak, Mukerrem

    2017-02-01

    A novel approach to zero-order constant-rate drug delivery from contact lenses is presented. Quasi-Case II non-Fickian transport is achieved by nonuniform drug and diffusivity distributions within three-layer bimodal amphiphilic conetworks (β-APCNs). The center layer is a highly oxygen permeable β-APCN matrix, which contains the drug and exhibits a high drug diffusivity. The outer β-APCN layers contain no-drug and are loaded with vitamin E, which slows diffusion. In contrast to single-layer neat-polymer and vitamin E-loaded films that display first-order "burst" kinetics, it is demonstrated experimentally and by modeling that the combined effect of nonuniform distribution of drug loading and diffusion constants within the three-layer lens maintains low local drug concentration at the lens-fluid interface and yields zero-order drug delivery. The release rates of topical antibiotics provide constant-rate therapeutic-level delivery with appropriate oxygen permeability for at least 30 h, at which time ≈25% of the drug was released.

  15. Slit-lamp management in contact lenses laboratory classes: learning upgrade with monitor visualization of webcam video recordings

    NASA Astrophysics Data System (ADS)

    Arines, Justo; Gargallo, Ana

    2014-07-01

    The training in the use of the slit lamp has always been difficult for students of the degree in Optics and Optometry. Instruments with associated cameras helps a lot in this task, they allow teachers to observe and control if the students evaluate the eye health appropriately, correct use errors and show them how to do it with a visual demonstration. However, these devices are more expensive than those that do not have an integrated camera connected to a display unit. With the aim to improve students' skills in the management of slit lamp, we have adapted USB HD webcams (Microsoft Lifecam HD-5000) to the objectives of the slit lamps available in our contact lenses laboratory room. The webcams are connected to a PC running Linux Ubuntu 11.0; therefore that is a low-cost device. Our experience shows that single method has several advantages. It allows us to take pictures with a good quality of different conditions of the eye health; we can record videos of eye evaluation and make demonstrations of the instrument. Besides it increases the interactions between students because they could see what their colleagues are doing and take conscious of the mistakes, helping and correcting each others. It is a useful tool in the practical exam too. We think that the method supports the training in optometry practice and increase the students' confidence without a huge outlay.

  16. Ultrahigh-Resolution Measurement by Optical Coherence Tomography of Dynamic Tear Film Changes on Contact Lenses

    PubMed Central

    Chen, Qi; Tao, Aizhu; Shen, Meixiao; Jiao, Shuliang; Lu, Fan

    2010-01-01

    Purpose. To determine the dynamic pre- and postlens tear film (PLTF and PoLTF) thicknesses by using optical coherence tomography (OCT). Methods. Ultrahigh-resolution OCT was used to image the tear film of 22 subjects before and after contact lens wear. A soft lens with 1 drop of artificial tears on its concave surface was inserted onto one randomly selected eye. OCT images were taken before insertion, immediately afterward, and every 2 minutes for 10 minutes. For the contralateral eye, the lens inserted was not prewetted on the concave surface. OCT images were taken before insertion, immediately afterward, and at 3 minutes. Then another drop was instilled, and images were taken immediately afterward and every 2 minutes for 10 minutes. Images were processed by custom software to yield tear film thickness. Results. The thickness of precorneal tear film (PCTF) was 1.9 ± 0.9 μm. The PoLTF was visualized clearly in all cases immediately after lens insertion, with 1 drop on the lens concave surface. Through the first 6 minutes after insertion, the PoLTF was greater than the PCTF. The PLTF (n = 12) and PoLTF (n = 9) were visualized immediately after lens insertion. After 3 minutes, the PLTF in most subjects and PoLTF in all subjects were invisible. The thickness of the PLTF increased after the instillation of artificial tears, whereas the PoLTF did not at any checkpoint for 10 minutes. Conclusions. Ultrahigh-resolution OCT is a promising tool for measuring the tear film. The PoLTF did not increase after instillation of artificial tears. PMID:19933178

  17. Approach to knowledge of the interaction between the constituents of contact lenses and ocular tears: mixed monolayers of poly(methyl methacrylate) and dipalmitoyl phosphatidyl choline.

    PubMed

    Miñones Conde, M; Conde, O; Trillo, J M; Miñones, J

    2011-04-05

    Mixed monolayers of poly(methyl methacrylate) (PMMA), the main component of hard contact lenses, and dipalmitoyl phosphatidyl choline (DPPC), a characteristic phospholipidic constituent of ocular tear films, were selected as an in vitro model in order to observe the behavior of contact lenses on the eye. Using Langmuir monolayer and Brewster angle microscopy (BAM) techniques, the interaction between both components was analyzed from the data of surface pressure-area isotherms, compressional modulus-surface pressure, and relative film thickness versus time elapsed from the beginning of compression, together with BAM images. Regardless of the surface pressure at which the molecular/monomer areas (A(m)) were recorded, the A(m) mole fractions of PMMA (X(PMMA)) plots show that the experimental results match the theoretical values calculated from additivity rule A(m) = X(PMMA)A(PMMA) + X(DPPC)A(DPPC). The application of the Crisp phase rule to the phase diagram of the PMMA-DPPC system can explain the existence of a mixed monolayer made up of miscible components with ideal behavior at surface pressures below 25 mN/m. However, at very high surface pressures, when collapse is reached (at 60 mN/m), the single collapsed components are segregated into two independent phases. These results allows us to argue that PMMA hard contact lenses in the eye do not alter the structural characteristics of the phospholipid (DPPC) in tears.

  18. Development of optoelectronic hardware: program complex for the analysis of hypoxia in the anterior eye camera in persons wearing contact lenses

    NASA Astrophysics Data System (ADS)

    Topakova, Anastassia A.; Salmin, Vladimir V.; Gar'kavenko, Victor V.; Levchenko, Julia S.; Lazarenko, Victor I.

    2016-04-01

    Fluorimetry of eye is a perspective technique for research and diagnostics in ophthalmology. It is connected to the structural and functional characteristics of eye that is, actually, the optical system allowing transferring the radiation both for excitation and for registration of fluorescence in different eye's compartments: cornea, lens, vitreous body, and fundus of the eye. At present, different models of ophthalmologic fluorophotometers for the analysis of eye fluorescence as well as more advanced models - scanning fluorophotometers - are offered. Assessment of corneal status in persons wearing contact lenses or in patients with pathological changes (i.e. diabetes mellitus) would give us an opportunity to identify the initial manifestations of corneal pathology at the pre-symptomatic phase. In this paper, we present data on the compact spectrofluorimeter with UV LEDs-induced excitation as well as the method for assessing hypoxic alterations in the eye limb zone caused by contact lenses wearing. We demonstrate dependence of autofluorescence spectra on the contact lenses types and duration of their permanent wearing.

  19. Fusarium and Candida albicans Biofilms on Soft Contact Lenses: Model Development, Influence of Lens Type, and Susceptibility to Lens Care Solutions▿

    PubMed Central

    Imamura, Yoshifumi; Chandra, Jyotsna; Mukherjee, Pranab K.; Lattif, Ali Abdul; Szczotka-Flynn, Loretta B.; Pearlman, Eric; Lass, Jonathan H.; O'Donnell, Kerry; Ghannoum, Mahmoud A.

    2008-01-01

    Fungal keratitis is commonly caused by Fusarium species and less commonly by Candida species. Recent outbreaks of Fusarium keratitis were associated with contact lens wear and with ReNu with MoistureLoc contact lens care solution, and biofilm formation on contact lens/lens cases was proposed to play a role in this outbreak. However, no in vitro model for contact lens-associated fungal biofilm has been developed. In this study, we developed and characterized in vitro models of biofilm formation on various soft contact lenses using three species of Fusarium and Candida albicans. The contact lenses tested were etafilcon A, galyfilcon A, lotrafilcon A, balafilcon A, alphafilcon A, and polymacon. Our results showed that clinical isolates of Fusarium and C. albicans formed biofilms on all types of lenses tested and that the biofilm architecture varied with the lens type. Moreover, differences in hyphal content and architecture were found between the biofilms formed by these fungi. We also found that two recently isolated keratitis-associated fusaria formed robust biofilms, while the reference ATCC 36031 strain (recommended by the International Organization for Standardization guidelines for testing of disinfectants) failed to form biofilm. Furthermore, using the developed in vitro biofilm model, we showed that phylogenetically diverse planktonic fusaria and Candida were susceptible to MoistureLoc and MultiPlus. However, Fusarium biofilms exhibited reduced susceptibility against these solutions in a species- and time-dependent manner. This in vitro model should provide a better understanding of the biology and pathogenesis of lens-related fungal keratitis. PMID:17999966

  20. Plasma polymer-coated contact lenses for the culture and transfer of corneal epithelial cells in the treatment of limbal stem cell deficiency.

    PubMed

    Brown, Karl David; Low, Suet; Mariappan, Indumathi; Abberton, Keren Maree; Short, Robert; Zhang, Hong; Maddileti, Savitri; Sangwan, Virender; Steele, David; Daniell, Mark

    2014-02-01

    Extensive damage to the limbal region of the cornea leads to a severe form of corneal blindness termed as limbal stem cell deficiency (LSCD). Whereas most cases of corneal opacity can be treated with full thickness corneal transplants, LSCD requires stem cell transplantation for successful ocular surface reconstruction. Current treatments for LSCD using limbal stem cell transplantation involve the use of murine NIH 3T3 cells and human amniotic membranes as culture substrates, which pose the threat of transmission of animal-derived pathogens and donor tissue-derived cryptic infections. In this study, we aimed to produce surface modified therapeutic contact lenses for the culture and delivery of corneal epithelial cells for the treatment of LSCD. This approach avoids the possibility of suture-related complications and is completely synthetic. We used plasma polymerization to deposit acid functional groups onto the lenses at various concentrations. Each surface was tested for its suitability to promote corneal epithelial cell adhesion, proliferation, retention of stem cells, and differentiation and found that acid-based chemistries promoted better cell adhesion and proliferation. We also found that the lenses coated with a higher percentage of acid functional groups resulted in a higher number of cells transferred onto the corneal wound bed in rabbit models of LSCD. Immunohistochemistry of the recipient cornea confirmed the presence of autologous, transplanted 5-bromo-2'-deoxyuridine (BrdU)-labeled cells. Hematoxylin staining has also revealed the presence of a stratified epithelium at 26 days post-transplantation. This study provides the first evidence for in vivo transfer and survival of cells transplanted from a contact lens to the wounded corneal surface. It also proposes the possibility of using plasma polymer-coated contact lenses with high acid functional groups as substrates for the culture and transfer of limbal cells in the treatment of LSCD.

  1. Plasma Polymer-Coated Contact Lenses for the Culture and Transfer of Corneal Epithelial Cells in the Treatment of Limbal Stem Cell Deficiency

    PubMed Central

    Brown, Karl David; Low, Suet; Mariappan, Indumathi; Abberton, Keren Maree; Short, Robert; Zhang, Hong; Maddileti, Savitri; Sangwan, Virender; Steele, David

    2014-01-01

    Extensive damage to the limbal region of the cornea leads to a severe form of corneal blindness termed as limbal stem cell deficiency (LSCD). Whereas most cases of corneal opacity can be treated with full thickness corneal transplants, LSCD requires stem cell transplantation for successful ocular surface reconstruction. Current treatments for LSCD using limbal stem cell transplantation involve the use of murine NIH 3T3 cells and human amniotic membranes as culture substrates, which pose the threat of transmission of animal-derived pathogens and donor tissue-derived cryptic infections. In this study, we aimed to produce surface modified therapeutic contact lenses for the culture and delivery of corneal epithelial cells for the treatment of LSCD. This approach avoids the possibility of suture-related complications and is completely synthetic. We used plasma polymerization to deposit acid functional groups onto the lenses at various concentrations. Each surface was tested for its suitability to promote corneal epithelial cell adhesion, proliferation, retention of stem cells, and differentiation and found that acid-based chemistries promoted better cell adhesion and proliferation. We also found that the lenses coated with a higher percentage of acid functional groups resulted in a higher number of cells transferred onto the corneal wound bed in rabbit models of LSCD. Immunohistochemistry of the recipient cornea confirmed the presence of autologous, transplanted 5-bromo-2′-deoxyuridine (BrdU)-labeled cells. Hematoxylin staining has also revealed the presence of a stratified epithelium at 26 days post-transplantation. This study provides the first evidence for in vivo transfer and survival of cells transplanted from a contact lens to the wounded corneal surface. It also proposes the possibility of using plasma polymer-coated contact lenses with high acid functional groups as substrates for the culture and transfer of limbal cells in the treatment of LSCD. PMID:24328453

  2. Short term wear of high Dk soft contact lenses does not alter corneal epithelial cell size or viability

    PubMed Central

    Stapleton, F.; Kasses, S.; Bolis, S.; Keay, L.

    2001-01-01

    BACKGROUND/AIMS—Current contact lenses (CLs) when worn on an extended wear basis cause corneal epithelial alterations. The aim of this study was to evaluate changes in corneal epithelial cell morphology and physiology following short term (3 months) wear of highly oxygen permeable CLs and to compare this with disposable CLs.
METHODS—Subjects were wearers of highly oxygen permeable CLs (n=11, wearing CLs on a 30 night schedule), disposable CL users (n=6, wearing CLs on a 6 night schedule), and non-CL wearers (n=20). Mean CL wear experience was 3 months. Epithelial cells were harvested using corneal cytology and were stained using acridine orange and ethidium bromide. Epithelial cell size and viability were determined.
RESULTS—The majority of epithelial cells recovered were non-viable (71%), and the mean longest cell diameter was 38 (SD 8) µm. Disposable CLs caused an increase in cell size (42 (7) µm) compared with both non-wear (39 (7) µm, p=0.01) and wear of highly oxygen permeable CLs (37 (10) µm, p=0.0049). There was no difference in cell viability between groups.
CONCLUSIONS—Extended wear of disposable CLs caused an 8% increase in cell diameter in harvested corneal epithelial cells following 3 months of CL wear. Cells harvested following 3 months' wear of highly oxygen permeable CLs were indistinguishable from those recovered from non-CL wearers.

 PMID:11159475

  3. Contact Lens Risks

    MedlinePlus

    ... Health and Consumer Devices Consumer Products Contact Lenses Contact Lens Risks Share Tweet Linkedin Pin it More ... redness blurred vision swelling pain Serious Hazards of Contact Lenses Symptoms of eye irritation can indicate a ...

  4. Glasses and Contact Lenses

    MedlinePlus

    ... about special eyewear you can wear on the field. With glasses, you'll also want to find out how to clean them properly. And it helps if you have a glasses case and put them in it when you're not wearing them. The last thing you want is to sit on your ...

  5. Purification and characterization of a novel cholesterol esterase from Pseudomonas aeruginosa, with its application to cleaning lipid-stained contact lenses.

    PubMed

    Sugihara, Akio; Shimada, Yuji; Nomura, Atsuo; Terai, Tadamasa; Imayasu, Masaki; Nagai, Yusuke; Nagao, Toshihiro; Watanabe, Yomi; Tominaga, Yoshio

    2002-11-01

    With the aim of developing a new cholesterol esterase for eliminating lipids on used contact lenses, microorganisms were screened for the enzyme activity. A Pseudomonas aeruginosa isolated from soil was found to produce a desirable enzyme. The enzyme had an isoelectric point of 3.2, and molecular mass of 58 kDa. The optimal temperature was around 53 degrees C at pH 7.0, and the optimal pH was from 5.5 to 9.5. The enzyme was stable between pH 5 and 10 for 19 h at 25 degrees C, and retained its activity up to 53 degrees C on 30 min of incubation at pH 7.0. The rates of hydrolysis of cholesteryl esters of different fatty acids were in the following order: linoleate > oleate > stearate > palmitate > caprylate > myristate > laurate, caprate > caproate > butyrate, acetate. Addition of (tauro)cholate to a final concentration of 100 mM markedly promoted the hydrolysis of triglycerides of short-, medium-, and long-chain fatty acids. When used with taurocholate, the enzyme acted as an effective cleaner for contact lenses stained with lipids consisting of cholesteryl oleate, tripalmitin, and stearyl stearate.

  6. Colored Contact Lens Dangers

    MedlinePlus

    ... Halloween Hazard: The Hidden Dangers of Buying Decorative Contact Lenses Without a Prescription Sep. 26, 2013 It ... the truth." Real People, Real Problems with Colored Contact Lenses Julian: Teenager Blinded In One Eye By ...

  7. Design and fabrication of the progressive addition lenses

    NASA Astrophysics Data System (ADS)

    Qin, Linling; Qian, Lin; Yu, Jingchi

    2011-11-01

    The use of progressive addition lenses (PALs) for the correction of presbyopia has increased dramatically in recent years. These lenses are now being used as the preferred alternative to bifocal and trifocal lenses in many parts of the world. Progressive addition lenses are a kind of opthalmic lenses with freeform surface. The surface curvature of the Progressive addition lenses varies gradually from a minimum value in the upper area, to a maximum value in the lower area. Thus a PAL has a surface with three zones which have very small astigmatism: far-view zone, near-view zone, and intermediate zone. The far view zone and near view zone have relatively constant powers and connected by the intermediate zone with power varies progressively. The design and fabrication technologies of progressive addition lenses have fast progresses because of the massive development of the optical simulation software, multi-axis ultraprecision machining technologies and CNC machining technologies. The design principles of progressive addition lenses are discussed in a historic review. Several kinds of design methods are illustrated, and their advantages and disadvantages are also represented. In the current study, it is shown that the optical characteristics of the different progressive addition lenses designs are significantly different from one another. The different fabrication technologies of Progressive addition lenses are also discussed in the paper. Plastic injection molding and precision-machine turning are the common fabrication technologies for exterior PALs and Interior PALs respectively.

  8. [Results of corneal and total astigmatism estimation by different methods in myopic patients wearing orthokeratology contact lenses].

    PubMed

    Tarutta, E P; Aliaeva, O O; Verzhanskaia, T Iu; Milash, S V

    2013-01-01

    Reports have been made that corneal aberrations of all orders, including astigmatism, often significantly increase with the use of night orthokeratology lenses. In this study the dynamic changes of total and corneal astigmatism in myopes using orthokeratology lenses was evaluated by different methods. The study enrolled 38 patients (76 eyes) with low and medium myopia (28 and 48 eyes correspondingly) and initial astigmatism less than 2 diopters. The assessment was made before and in different terms after the patient started to wear orthokeratology lenses. Induced astigmatism (> or =1 diopter) was found in more than 50% of cases. The degree of astigmatism gradually increased from the centre to the periphery within the papillary zone. The maximum values were found within a 4-mm zone ("uptake zone") and minimal - within a 8-mm zone ("equalization zone"). In all patients, despite the presence of induced astigmatism and residual myopia (0.83+/-0.09 diopters in average), distance visual acuity was high enough without an additional correction (0.82+/-0.05 in average). Apparently, in these patients the aberrations (astigmatism in particular) exceed the focal depth.

  9. COMPARATION OF REFRACTIVE RESULTS WITH BIFOCAL IMPLANTS AT LISA 809 AND TRIFOCAL AT LISA TRI839.

    PubMed

    Postolache, Cristian; Postolache, Oana

    2015-01-01

    The purpose of this paper is to make a comparison between the results obtained with AT LISA 809 bifocal IOL and trifocal AT LISA 839. Interest was represented especially by the evaluation of intermediate vision for the 2 implants. 18 patients (36 eyes) operated in Gauss Clinic in 2014 were included in the study: 9 patients (18 eyes) with bifocal implant AT LISA 809 and 9 patients (18 eyes) with bilateral implantation AT LISA 839 trifocal lens. Results showed that implant trifocal provided better visual results for intermediate vision to bifocal implant, as there were not significant differences between the two, in terms of distance vision and near vision.

  10. Focusing on Contact Lens Safety

    MedlinePlus

    ... Consumers Home For Consumers Consumer Updates Focusing on Contact Lens Safety Share Tweet Linkedin Pin it More ... substantial consumer injury. Back to top Types of Contact Lenses General categories Soft contact lenses. These are ...

  11. A human performance/workload evaluation of the AN/PVS-5 bifocal night vision goggles.

    PubMed

    Stone, L W; Sanders, M G; Glick, D D; Wiley, R W; Kimball, K A

    1980-08-01

    Eight experienced U.S. Army aviators performed various maneuvers in an instrumented helicopter to test the relative usability of two bifocal-configured night vision goggles. Both configurations were statistically better than the unmodified arrangement when looking at a pilot's ability to fly a standard traffic pattern and to hold a precise altitude at night. The subjective data, supported by comparative flight performances with the two bifocals, further suggested that a 24% bifocal version was more desirable than a 14% configuration. The inference is that the reduced inside field of view presented by the 14% bifocal interferes with a pilot's ability to readily locate instruments once he has directed his attention inside the cockpit.

  12. A case of bifocal endometriosis involving a pfannenstiel incision.

    PubMed

    Evsen, Mehmet Sidik; Sak, Muhammet Erdal; Yalinkaya, Ahmet; Firat, Ugur; Caca, Fatma Nur

    2011-01-01

    A 25-year-old woman was referred to our clinic for atypical cyclic pain and masses at both ends of a Pfannenstiel incision scar. Ultrasound of the anterior abdominal wall showed two masses. Both masses were hypoechoic, heterogeneous lesions located at opposite ends of the scar. The lesions were surgically excised with. Microscopic examination revealed endometrial gland structures with endometrial stroma in fibroadipose tissue in sections of both specimens indicative of endometriosis. Incisional endometriosis (IE) is a form of extrapelvic endometriosis especially in scars of obstetric or gynecologic surgery IE may be multifocal at surgical scars. We report the a case of bifocal incisional endometriosis in Pfannesteil scar. Whole scar evaluation should be done for incisional endometriosis and surgical excision should be performed for treatment.

  13. The effect of modification procedures on rigid gas permeable contact lenses: the UM-St. Louis Study.

    PubMed

    Morgan, B W; Henry, V A; Bennett, E S; Caroline, P J

    1992-03-01

    The purpose of this study is to evaluate the effect of frequently performed modification procedures on quality of vision, surface wettability, optical quality and subjective response. One subject was optimally fitted with both silicone/acrylate (S/A) and fluoro-silicone/acrylate (F-S/A) lens materials of identical design. Two methods of surface polishing, edge polishing and repowering were used in addition to three different spindle speeds. Each pair of lenses was worn by the subject for a period of 4 hours and the subjective response was then compared to the baseline or premodification data. In addition, both low magnification photography and Scanning Electron Microscopy (S.E.M.) were performed on each lens. The results showed that the addition of 0.50D minus power reduced visual acuity, contrast sensitivity function and optical quality with one of the methods used. Front surface polish and edge polish procedures did not appear to affect short-term performance. Controlling polish, application and tool pressure on certain procedures resulted in similar findings. Further studies would be beneficial to evaluate the effect of longer wearing periods and the use of other modification procedures. The authors conclude that S/A and F-S/A lens materials can be successfully modified in-office with adherence to recommended guidelines.

  14. Release of Moxifloxacin from Contact Lenses Using an In Vitro Eye Model: Impact of Artificial Tear Fluid Composition and Mechanical Rubbing

    PubMed Central

    Phan, Chau-Minh; Bajgrowicz-Cieslak, Magdalena; Subbaraman, Lakshman N.; Jones, Lyndon

    2016-01-01

    Purpose The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model. Methods Four commercially available DD conventional hydrogel (CH) CLs (nelfilcon A, omafilcon A, etafilcon A, and ocufilcon B) and three silicone hydrogel (SH) CLs (somofilcon A, narafilcon A, and delefilcon A) were evaluated. These lenses were incubated in moxifloxacin for 24 hours. The release of the drug was measured using a novel in vitro model in three experimental conditions: (1) phosphate buffered saline (PBS); (2) artificial tear solution (ATS) containing a variety of proteins and lipids; and (3) ATS with mechanical rubbing produced by the device. Results Overall, CH CLs had a higher drug release than SH CLs (P < 0.05) under all conditions. Typically, a higher drug release was observed in PBS than ATS (P < 0.05). For CH, drug release was found to be higher in ATS with rubbing than PBS or ATS (P < 0.05). For most lens types, ATS with rubbing produced higher drug release than ATS alone (P < 0.05). Generally, the release kinetics for all conditions were sustained over the 24-hour testing period, and no burst release was observed (P < 0.05). Conclusions Moxifloxacin release from a CL into ATS is lower when compared to release into PBS. When mechanical rubbing is introduced, the amount of drugs released is increased. Translational Relevance Results suggest that sophisticated in vitro models are necessary to adequately model on-eye drug release from CL materials. PMID:27847690

  15. Evaluation of povidone-iodine as a disinfectant solution for contact lenses: antimicrobial activity and cytotoxicity for corneal epithelial cells.

    PubMed

    Yanai, Ryoji; Yamada, Naoyuki; Ueda, Kiichi; Tajiri, Motoharu; Matsumoto, Toru; Kido, Keiji; Nakamura, Shigeru; Saito, Fumio; Nishida, Teruo

    2006-05-01

    Povidone-iodine (PVP-I) possesses broad-spectrum antimicrobial activity and is used clinically as a disinfectant. We evaluated the disinfectant properties and safety of PVP-I for use as a contact lens solution. The concentrations of PVP-I required to reduce the number of Staphylococcus aureus or Candida albicans by 3 log units were lower than were those of hydrogen peroxide, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BAK). The cytotoxicity of PVP-I for cultured human corneal epithelial (HCE) cells was less than that of the other three agents. The safety margin for PVP-I was thus greatest among the tested compounds. PVP-I appears suited for use as a contact lens disinfectant.

  16. Bifocal Optical-Vortex Lens with Sorting of the Generated Nonseparable Spin-Orbital Angular-Momentum States

    NASA Astrophysics Data System (ADS)

    Tam, Alwin M. W.; Fan, Fan; Du, Tao; Hu, Wei; Zhang, Wanlong; Zhao, Chenxiang; Wang, Xiaoqian; Ching, Kwong-Lung; Li, Guijun; Luo, Hailu; Chigrinov, Vladimir G.; Wen, Shuangchun; Kwok, Hoi-Sing

    2017-03-01

    In this article, we devise and demonstrate experimentally a polarization-dependent diffractive bifocal vortex lens operating via the Pancharatnam-Berry phase. The interaction between the incident beam and the bifocal vortex lens establishes nonseparable spin and orbital angular-momentum photon states. The components of the nonseparable state associated with different couplings of spin and orbital angular momentum can be sorted by the bifocality of the lens. A theoretical model of the device is developed using Fresnel's diffraction. The device is simply, efficiently, and economically realized from the optical setup using the underlying physics of Pancharatnam-Berry-phase polarization holography. The measured transmittance and diffraction efficiency of the fabricated device is high—up to 90% and 91%, respectively. Various applications of the polarization bifocal vortex lens in the field of orbital angular-momentum lasing and optical manipulation are discussed. Thus, the bifocal vortex lens can have significant impact on classical and quantum optics, as well as theoretical physics.

  17. Improvement of the surface wettability of silicone hydrogel contact lenses via layer-by-layer self-assembly technique.

    PubMed

    Lin, Chien-Hong; Cho, Hsien-Lung; Yeh, Yi-Hsing; Yang, Ming-Chien

    2015-12-01

    The surface wettability and anti-protein adsorption of a silicone-based hydrogel that was synthesized by a block copolymer of polydimethylsiloxane (PDMS) and poly (ethylene glycol) methacrylate (PEGMA) was improved via polyelectrolyte multilayer (PEM) immobilization. Polysaccharide PEMs of chitosan (CS, as a positive-charged agent) and hyaluronic acid (HA, as a negative-charged and anti-adhesive agent) were successfully assembled on the PDMS-PU-PEGMA silicone hydrogel in a layer-by-layer (LBL) self-assembly manner. Atomic force microscopy (AFM) and dyeing data verified the progressive buildup of the PEM silicone hydrogel. The results showed that the contact angle of the silicone hydrogel decreased with an increase in the number of PEM grafting layers. Furthermore, after immobilizing five layers of CS/HA, the protein adsorption decreased from 78 ± 11 to 26 ± 4 μg/cm(2) for HSA and from 55 ± 10 to 20 ± 4 μg/cm(2) for lysozymes. This indicates that CS/HA PEM-immobilized silicone hydrogels can resist protein adsorption. Furthermore, these hydrogels were non-cytotoxic according to an in vitro L929 fibroblast assay. Overall, the results demonstrated that the modified silicone hydrogels exhibited hydrophilicity and anti-protein adsorption, as well as relatively high oxygen permeability and optical transparency. Therefore, they would be applicable as a contact lens material.

  18. 18S Ribosomal DNA Typing and Tracking of Acanthamoeba Species Isolates from Corneal Scrape Specimens, Contact Lenses, Lens Cases, and Home Water Supplies of Acanthamoeba Keratitis Patients in Hong Kong

    PubMed Central

    Booton, G. C.; Kelly, D. J.; Chu, Y.-W.; Seal, D. V.; Houang, E.; Lam, D. S. C.; Byers, T. J.; Fuerst, P. A.

    2002-01-01

    We examined partial 18S ribosomal DNA (Rns) sequences of Acanthamoeba isolates cultured in a study of microbial keratitis in Hong Kong. Sequence differences were sufficient to distinguish closely related strains and were used to examine links between strains obtained from corneal scrape specimens, contact lenses, lens cases, lens case solutions, and home water-supply faucets of patients with Acanthamoeba. We also looked for evidence of mixed infections. Identification of Acanthamoeba Rns genotypes was based on sequences of ∼113 bp within the genus-specific amplicon ASA.S1. This permitted genotype identification by using nonaxenic cultures. Of 13 specimens obtained from corneal scrapes, contact lenses, lens cases, or lens case solutions, 12 were Rns genotype T4 and the remaining one was Rns genotype T3. The sequences of corneal scrape specimens of two patients also were the same as those obtained from their contact lenses or lens case specimens. A possible triple-strain infection was indicated by three different T4 sequences in cultures from one patient's lenses. Although faucet water used by patients to clean their lenses is a possible source of infections, specimens isolated from the faucets at two Acanthamoeba keratitis patients' homes differed from their corneal scrape or lens specimens. The overall results demonstrate the potential of this Rns region for tracking Acanthamoeba keratitis strains in infections and for distinguishing single-strain and closely related multiple-strain infections even when other microorganisms might be present with the cultured specimens. They also confirm the predominance of Rns genotype T4 strains in Acanthamoeba keratitis infections. PMID:11980931

  19. 18S ribosomal DNA typing and tracking of Acanthamoeba species isolates from corneal scrape specimens, contact lenses, lens cases, and home water supplies of Acanthamoeba keratitis patients in Hong Kong.

    PubMed

    Booton, G C; Kelly, D J; Chu, Y-W; Seal, D V; Houang, E; Lam, D S C; Byers, T J; Fuerst, P A

    2002-05-01

    We examined partial 18S ribosomal DNA (Rns) sequences of Acanthamoeba isolates cultured in a study of microbial keratitis in Hong Kong. Sequence differences were sufficient to distinguish closely related strains and were used to examine links between strains obtained from corneal scrape specimens, contact lenses, lens cases, lens case solutions, and home water-supply faucets of patients with Acanthamoeba. We also looked for evidence of mixed infections. Identification of Acanthamoeba Rns genotypes was based on sequences of approximately 113 bp within the genus-specific amplicon ASA.S1. This permitted genotype identification by using nonaxenic cultures. Of 13 specimens obtained from corneal scrapes, contact lenses, lens cases, or lens case solutions, 12 were Rns genotype T4 and the remaining one was Rns genotype T3. The sequences of corneal scrape specimens of two patients also were the same as those obtained from their contact lenses or lens case specimens. A possible triple-strain infection was indicated by three different T4 sequences in cultures from one patient's lenses. Although faucet water used by patients to clean their lenses is a possible source of infections, specimens isolated from the faucets at two Acanthamoeba keratitis patients' homes differed from their corneal scrape or lens specimens. The overall results demonstrate the potential of this Rns region for tracking Acanthamoeba keratitis strains in infections and for distinguishing single-strain and closely related multiple-strain infections even when other microorganisms might be present with the cultured specimens. They also confirm the predominance of Rns genotype T4 strains in Acanthamoeba keratitis infections.

  20. Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling.

    PubMed

    Pimenta, A F R; Valente, A; Pereira, J M C; Pereira, J C F; Filipe, H P; Mata, J L G; Colaço, R; Saramago, B; Serro, A P

    2016-12-01

    Currently, most in vitro drug release studies for ophthalmic applications are carried out in static sink conditions. Although this procedure is simple and useful to make comparative studies, it does not describe adequately the drug release kinetics in the eye, considering the small tear volume and flow rates found in vivo. In this work, a microfluidic cell was designed and used to mimic the continuous, volumetric flow rate of tear fluid and its low volume. The suitable operation of the cell, in terms of uniformity and symmetry of flux, was proved using a numerical model based in the Navier-Stokes and continuity equations. The release profile of a model system (a hydroxyethyl methacrylate-based hydrogel (HEMA/PVP) for soft contact lenses (SCLs) loaded with diclofenac) obtained with the microfluidic cell was compared with that obtained in static conditions, showing that the kinetics of release in dynamic conditions is slower. The application of the numerical model demonstrated that the designed cell can be used to simulate the drug release in the whole range of the human eye tear film volume and allowed to estimate the drug concentration in the volume of liquid in direct contact with the hydrogel. The knowledge of this concentration, which is significantly different from that measured in the experimental tests during the first hours of release, is critical to predict the toxicity of the drug release system and its in vivo efficacy. In conclusion, the use of the microfluidic cell in conjunction with the numerical model shall be a valuable tool to design and optimize new therapeutic drug-loaded SCLs.

  1. Contact Lens Care

    MedlinePlus

    ... For Consumers Consumer Information by Audience For Women Contact Lens Care Share Tweet Linkedin Pin it More ... 1088, www.fda.gov/medwatch Learn More about Contact Lens Care Other Tips on Contact Lenses Decorative ...

  2. Fresnel lenses for ultrasonic inspection

    NASA Technical Reports Server (NTRS)

    Kammerer, C. C.

    1980-01-01

    Ultrasonic Fresnel lenses are effective focusing elements with potential applications in ultrasonic "contact" testing for defects in materials. Ultrasonic beams focused on concave lenses are used successfully with immersion transducers, for which test object is immersed in water bath. However, for large objects, objects that are already installed, objects on production lines, and objects that can be damaged by water, contact testing is more practical than immersion.

  3. A three-phase in-vitro system for studying Pseudomonas aeruginosa adhesion and biofilm formation upon hydrogel contact lenses

    PubMed Central

    2010-01-01

    Background Pseudomonas aeruginosa is commonly associated with contact lens (CL) -related eye infections, for which bacterial adhesion and biofilm formation upon hydrogel CLs is a specific risk factor. Whilst P. aeruginosa has been widely used as a model organism for initial biofilm formation on CLs, in-vitro models that closely reproduce in-vivo conditions have rarely been presented. Results In the current investigation, a novel in-vitro biofilm model for studying the adherence of P. aeruginosa to hydrogel CLs was established. Nutritional and interfacial conditions similar to those in the eye of a CL wearer were created through the involvement of a solid:liquid and a solid:air interface, shear forces and a complex artificial tear fluid. Bioburdens varied depending on the CL material and biofilm maturation occurred after 72 h incubation. Whilst a range of biofilm morphologies were visualised including dispersed and adherent bacterial cells, aggregates and colonies embedded in extracellular polymer substances (EPS), EPS fibres, mushroom-like formations, and crystalline structures, a compact and heterogeneous biofilm morphology predominated on all CL materials. Conclusions In order to better understand the process of biofilm formation on CLs and to test the efficacy of CL care solutions, representative in-vitro biofilm models are required. Here, we present a three-phase biofilm model that simulates the environment in the eye of a CL wearer and thus generates biofilms which resemble those commonly observed in-situ. PMID:21062489

  4. Rigid lenses: an overview.

    PubMed

    Bayshore, C A

    1979-03-01

    New gas permeable rigid contact lens materials, by allowing direct transmission of oxygen, provide significant advantages over PMMA. Edema resulting from oxygen deprivation with PMMA lenses is eliminated and comfort is increased. Three types of gas permeable materials are described: CAB, silicone, and a combination of CAB and silicone.

  5. Pupil diameter, working distance and illumination during habitual tasks. Implications for simultaneous vision contact lenses for presbyopia

    PubMed Central

    Cardona, Genís; López, Sílvia

    2015-01-01

    Purpose To determine working distance, pupil diameter and illumination in real life conditions in a sample of presbyopic participants performing habitual tasks. Methods A total of 59 presbyopic subjects (aged between 45 and 63 years) with different occupational backgrounds participated in the study. Participants were first interviewed regarding their habitual tasks with the aid of an ad hoc questionnaire, following which in-office photopic and mesopic pupil diameter was determined. Pupil diameter was also evaluated while participants conducted each of the self-reported habitual tasks by taking a photograph, which was later submitted to image analysis. In addition, working distance was determined with a measuring tape and the illumination that reached the pupil during each of the different tasks was measured, in lux, with a light meter. Results The four most common habitual tasks were computer use, reading, sewing and sports. A high intersubject variability was found in pupil diameter, working distance and illumination conditions while conducting the same task. Statistically significant differences were found between the in-office measured photopic and mesopic pupil diameters and those obtained while participants were conducting their habitual tasks in real life conditions (all p < 0.001). Conclusions Potential multifocal contact lens users may present with different ages, different jobs or hobbies and different preferences regarding lighting conditions and working distances. This results in different pupil size, even within the same task. This information may be critical when selecting a particular lens design and add power. Eye care practitioners are therefore advised to assess pupil diameter in real life conditions. PMID:26481439

  6. Focusing properties of diffractive lenses constructed with the aperiodic m-bonacci sequence

    NASA Astrophysics Data System (ADS)

    Furlan, Walter D.; Ferrando, Vicente; Monsoriu, Juan A.

    2015-01-01

    In this contribution we present a new family of diffractive lenses which are designed using the m-bonacci sequence. These lenses are a generalization of the Fibonacci Zone Plates previously reported. Diffractive elements of this type are called aperiodic zone plates because they are characterized by a radial profile that follows a given deterministic aperiodic sequence (Cantor set, Thue-Morse, Fibonacci...). Aperiodic lenses have demonstrated new interesting focusing and imaging properties that have found applications in different fields such as soft X-ray microscopy and spectral domain optical coherence tomography. Here, we show that m-bonacci zone plates are inherently bifocal lenses. We demonstrate that the relative separation of their foci depends on the m-value of the sequence and also can be correlated with the generalized golden ratio. As a particular case, the properties of the m-bonacci sequence with m=2 and m=3, called Fibonacci and Tribonacci Zone Plates respectively are discussed.

  7. Optical contact micrometer

    DOEpatents

    Jacobson, Steven D.

    2014-08-19

    Certain examples provide optical contact micrometers and methods of use. An example optical contact micrometer includes a pair of opposable lenses to receive an object and immobilize the object in a position. The example optical contact micrometer includes a pair of opposable mirrors positioned with respect to the pair of lenses to facilitate viewing of the object through the lenses. The example optical contact micrometer includes a microscope to facilitate viewing of the object through the lenses via the mirrors; and an interferometer to obtain one or more measurements of the object.

  8. Critical Bifocality and Circuits of Privilege: Expanding Critical Ethnographic Theory and Design

    ERIC Educational Resources Information Center

    Weis, Lois; Fine, Michelle

    2012-01-01

    In this article, Lois Weis and Michelle Fine introduce critical bifocality as a way to render visible the relations between groups to structures of power, to social policies, to history, and to large sociopolitical formations. In this collaboration, the authors draw upon ethnographic examples highlighting the macro-level structural dynamics…

  9. Posterior arch bifocal fracture of the atlas vertebra: a variant of Jefferson fracture.

    PubMed

    Abuamara, S; Dacher, J N; Lechevallier, J

    2001-07-01

    Fracture of the atlas vertebra is rare in children. We report two paediatric cases of bifocal pedicular fracture of the posterior arch of C1. Evaluation was performed by nonenhanced computed tomography scan, which successively confirmed both diagnosis and healing. In both cases, nonoperative management was successful.

  10. Tracking and Pointing of Target by a Bifocal Relay Mirror Spacecraft Using Attitude Control and Fast Steering Mirrors Tilting

    DTIC Science & Technology

    2002-08-01

    proposed for the tracking and pointing of the target of the Bifocal Relay Mirror. The attitude control system consists of reaction wheels , star trackers and...nautics, Inc. with permission. T Transmitter portion of the spacecraft w Reaction wheel m Mirror rel Relative B Acronyms BRM Bifocal Relay Mirror...tem are respectively OR and OS . The other bodies considered in the dynamic model are: • four reaction wheels mounted in tetrahedral configuration on

  11. Fabrication of bifocal microlens arrays based on controlled electrohydrodynamic reflowing of pre-patterned polymer

    NASA Astrophysics Data System (ADS)

    Hu, Hong; Tian, Hongmiao; Shao, Jinyou; Ding, Yucheng; Jiang, Chengbao; Liu, Hongzhong

    2014-09-01

    An easy method based on electrohydrodynamic (EHD) reflowing of pre-patterned polymer is proposed in this study for the fabrication of bifocal microlens arrays (MLAs). The method comprises two sequential steps, i.e. hot embossing for generating a polymer-based micropillar array and EHD reflowing of the micropillars for the formation of a bifocal MLA with controllable surface shape and optical performance. The EHD reflowing process is achieved by applying a voltage across an electrode pair sandwiching an air gap and the pre-patterned polymer, and the EHD force induced on the air-polymer interface reshapes the pillar array into the MLA. The complex bifocal microlens can be achieved only when the electric intensity is stronger than that required to produce a commonly known Taylor cone, which is formed when the EHD force exactly surpasses the surface tension. Finally, the light through MLA is imaged on a moving charge-coupled device (CCD) camera and leads to an observation of two focal planes.

  12. Comparing the relative peripheral refraction effect of single vision and multifocal contact lenses measured using an autorefractor and an aberrometer: A pilot study

    PubMed Central

    Bakaraju, Ravi C.; Fedtke, Cathleen; Ehrmann, Klaus; Ho, Arthur

    2015-01-01

    Purpose To compare the contributions of single vision (SVCL) and multifocal contact lenses (MFCL) to the relative peripheral refraction (RPR) profiles obtained via an autorefractor and an aberrometer in a pilot study. Methods Two instruments, Shin-Nippon NVision K5001 (SN) and COAS-HD, were modified to permit open field PR measurements. Two myopic adults (CF, RB) were refracted (cycloplegia) under eight conditions: baseline (no CL); three SVCLs: Focus Dailies® (Alcon, USA), PureVision® (Bausch & Lomb, USA) and AirOptix® (Alcon, USA); and four MFCLs: AirOptix® (Alcon, USA), Proclear® Distant and Near (Cooper Vision, USA), and PureVision® (Bausch & Lomb, USA). CLs had a distance prescription of −2.00D and for MFCLs, a +2.50D Add was selected. Five independent measurements were performed at field angles from −40° to +40° in 10° increments with both instruments. The COAS-HD measures were analyzed at 3 mm pupil diameter. Results are reported as a change in the relative PR profile, as refractive power vector components: M, J180, and J45. Results Overall, at baseline, M, J180 and J45 measures obtained with SN and COAS-HD were considerably different only for field angles ≥±30°, which agreed well with previous studies. With respect to M, this observation held true for most SVCLs with a few exceptions. The J180 measures obtained with COAS-HD were considerably greater in magnitude than those acquired with SN. For SVCLs, the greatest difference was found at −40° for AirOptix SV (ΔCF = 3.20D, ΔRB = 1.56D) and for MFCLs it was for Proclear Distance at −40° (ΔCF = 2.58D, ΔRB = 1.39D). The J45 measures obtained with SN were noticeably different to the respective measures with COAS-HD, both in magnitude and sign. The greatest difference was found with AirOptix Multifocal in subject RB at −40°, where the COAS-HD measurement was 1.50D more positive. In some cases, the difference in the RPR profiles observed between subjects appeared to be

  13. Wettability and silicone hydrogel lenses: a review.

    PubMed

    Keir, Nancy; Jones, Lyndon

    2013-01-01

    One of the major breakthroughs in the development of silicone hydrogel contact lenses has related to the ability of manufacturers to overcome the surface hydrophobicity that occurred with silicone elastomer lenses. However, the wettability of silicone hydrogel lenses continues to be of interest as a potential link between in vivo lens performance and contact lens-related comfort. This article will review some of the knowledge we have gained in the area of contact lens wettability over the past decade and will discuss some of the challenges related to its measurement.

  14. Lensing duct

    DOEpatents

    Beach, Raymond J. , Benett

    1994-01-01

    A lensing duct to condense (intensify) light using a combination of front surface lensing and reflective waveguiding. The duct tapers down from a wide input side to a narrow output side, with the input side being lens-shaped and coated with an antireflective coating for more efficient transmission into the duct. The four side surfaces are uncoated, preventing light from escaping by total internal reflection as it travels along the duct (reflective waveguiding). The duct has various applications for intensifying light, such as in the coupling of diode array pump light to solid state lasing materials, and can be fabricated from inexpensive glass and plastic.

  15. Lensing duct

    DOEpatents

    Beach, R.J.; Benett, W.J.

    1994-04-26

    A lensing duct to condense (intensify) light using a combination of front surface lensing and reflective waveguiding is described. The duct tapers down from a wide input side to a narrow output side, with the input side being lens-shaped and coated with an antireflective coating for more efficient transmission into the duct. The four side surfaces are uncoated, preventing light from escaping by total internal reflection as it travels along the duct (reflective waveguiding). The duct has various applications for intensifying light, such as in the coupling of diode array pump light to solid state lasing materials, and can be fabricated from inexpensive glass and plastic. 3 figures.

  16. Ophthalmic halo reduced lenses design

    NASA Astrophysics Data System (ADS)

    Limon, Ofer; Zalevsky, Zeev

    2015-05-01

    The halo effect is a very problematic visual artifact occurring in extended depth of focus or multi-focal ophthalmic lenses such as e.g. intra-ocular (after cataract surgery) or contact lenses when used in dark illumination conditions. This artifact is generated due to surface structures added on top of those lenses in order to increase their depth of focus or to realize multiple focal lengths. In this paper we present novel solution that can resolve this major problem of ophthalmic lenses. The proposed solution involves modification to the surface structure that realizes the extended depth of focus. Our solution is fabricated and numerically and experimentally validated also in preliminary in-vivo trials.

  17. Contact Lens-Related Eye Infections

    MedlinePlus

    ... Stories Español Eye Health / Eye Health A-Z Contact Lens-Related Eye Infections Sections Contact Lens-Related ... About Contact Lenses Proper Care of Contact Lenses Contact Lens-Related Eye Infections Written by: Kierstan Boyd ...

  18. Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type and susceptibility to lens care solutions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fungal keratitis is commonly caused by Fusarium species, while cases of Candida-associated keratitis are less frequent. Recent outbreaks of Fusarium keratitis were associated with contact lens wear and with MoistureLoc contact lens care solution, and biofilm formation on contact lens/lens cases was...

  19. Gravitational Lensing

    SciTech Connect

    Lincoln, Don

    2015-06-24

    In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

  20. Gravitational Lensing

    ScienceCinema

    Lincoln, Don

    2016-07-12

    In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

  1. Phakic Intraocular Lenses

    MedlinePlus

    ... Implants and Prosthetics Phakic Intraocular Lenses Phakic Intraocular Lenses Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print Phakic intraocular lenses are new devices used to correct nearsightedness. These ...

  2. Using the Bifocal Modeling Framework to Resolve "Discrepant Events" between Physical Experiments and Virtual Models in Biology

    ERIC Educational Resources Information Center

    Blikstein, Paulo; Fuhrmann, Tamar; Salehi, Shima

    2016-01-01

    In this paper, we investigate an approach to supporting students' learning in science through a combination of physical experimentation and virtual modeling. We present a study that utilizes a scientific inquiry framework, which we call "bifocal modeling," to link student-designed experiments and computer models in real time. In this…

  3. A novel approach to measuring the wettability of rigid contact lenses. Mass measurement of the adherent liquid on the rigid lens surface (1).

    PubMed

    Shirafkan, A; Woodward, E G; Hull, C C

    1995-11-01

    A novel approach and the equilibrium sessile drop (laser assisted) method were used to determine the wettability of hydrated and unhydrated PMMA, Polycon II, Boston IV, Equalens and Boston RXD rigid contact lens materials. In the new method the ability of the contact lens surface to attract the liquid is evaluated by measuring the adhered mass of liquid on the front lens surface. The mass has a direct relationship to contact lens wettability, so the greater the lens surface hydrophilicity the more liquid adheres to the contact lens surface. In the hydrated state, Equalens and Boston IV showed the greatest hydrophilicity of all five materials, although there was no significant difference between them (P > 0.9). Boston RXD had a lower ability to attract liquid and there was a significant difference between it and the next higher material which was Boston IV (P < 0.005) and also the next lowest Polycon II (P < 0.00001). PMMA had the lowest capability to adhere liquid and there was a significant difference between PMMA and Polycon II (P < 0.00001). The new method is simple and quick to use and gives greater discrimination and repeatability than other current methods.

  4. Gravitational lenses

    SciTech Connect

    Turner, E.L.

    1988-07-01

    For several years astronomers have devoted considerable effort to finding and studying a class of celestial phenomena whose very existence depends on rare cosmic accidents. These are gravitational-lens events, which occur when two or more objects at different distances from the earth happen to lie along the same line of sight and so coincide in the sky. The radiation from the more distant object, typically a quasar, is bent by the gravitational field of the foreground object. The bending creates a cosmic mirage: distorted or multiple images of the background object. Such phenomena may reveal many otherwise undetectable features of the image source, of the foreground object and of the space lying between them. Such observations could help to resolve several fundamental questions in cosmology. In the past decade theoretical and observational research on gravitational lenses has grown rapidly and steadily. At this writing at least 17 candidate lens systems have been discussed in the literature. Of the 17 lens candidates reported so far in professional literature, only five are considered to have been reliably established by subsequent observations. Another three are generally regarded as weak or speculative cases with less than 50 percent chance of actually being lens systems. In the remaining nine cases the evidence is mixed or is sparse enough so that the final judgment could swing either way. As might be concluded, little of the scientific promise of gravitational lenses has yet been realized. The work has not yielded a clear value for the proportionality constant or any of the other fundamental cosmological parameter. 7 figs.

  5. The effect of rigid gas permeable lenses on corneal sensitivity.

    PubMed

    Bergenske, P D; Polse, K A

    1987-03-01

    Long term wear of hard (PMMA) contact lenses decreases corneal sensitivity. Clinicians have noted that in some patients who are refitted with rigid gas permeable (RGP) lenses, there is often an increase in lens awareness. To document this symptom, we monitored changes in corneal sensitivity of long term PMMA wearers who were refitted with RGP lenses. Corneal sensitivity measurements were conducted over a 6-month period. During this time, corneal touch threshold decreased to normal levels within a few weeks after refitting with RGP lenses. These results suggest an oxygen dependency factor in the control of corneal sensitivity accompanying contact lens wear.

  6. Contact Lens Visual Rehabilitation in Keratoconus and Corneal Keratoplasty

    PubMed Central

    Ozkurt, Yelda; Atakan, Mehmet; Gencaga, Tugba; Akkaya, Sezen

    2012-01-01

    Keratoconus is the most common corneal distrophy. It's a noninflammatory progressive thinning process that leads to conical ectasia of the cornea, causing high myopia and astigmatism. Many treatment choices include spectacle correction and contact lens wear, collagen cross linking, intracorneal ring segments implantation and finally keratoplasty. Contact lenses are commonly used to reduce astigmatism and increase vision. There are various types of lenses are available. We reviewed soft contact lenses, rigid gas permeable contact lenses, piggyback contact lenses, hybrid contact lenses and scleral-semiscleral contact lenses in keratoconus management. The surgical option is keratoplasty, but even after sutur removal, high astigmatism may stil exists. Therefore, contact lens is an adequate treatment option to correct astigmatism after keratoplasty. PMID:22292112

  7. A very rare Presentation of Bifocal Non Union Radius with Ipsilateral Ulnar Shaft Non Union: Case Report

    PubMed Central

    Padha, Vikas; Awasthi, Bhanu; Singh, Dhananjay; Kalia, Sandeep

    2016-01-01

    Introduction: A bifocal non-union of shaft of radius associated with ipsilateral non-union shaft of ulna in an adult has not been reported in the literature till date to the best of our knowledge, though few similar cases of fresh fractures have been reported. The case being reported by us is the first of its kind. Case Presentation: We report a case of bifocal non-union of shaft radius with non-union ipsilateral shaft of ulna in a 48-year-old right handed male along with discussion of alternative treatment options. Conclusion: We describe an extremely rare and complicated non-union in which our patient got excellent results along with satisfactory functional recovery as a result of appropriate surgical treatment. PMID:27299137

  8. [Changes of distraction regeneration in the process of bifocal substitution of osteal defect in patients with chronic osteomyelitis].

    PubMed

    Sulyma, V S

    2002-04-01

    Comparative results of roentgenologic and ultrasonic investigation (USI) of distractional regenerate during performance of bifocal substitution of long bone defect in 185 patients with chronic osteomyelitis were analyzed. Predominance of USI on early stages of the regenerate formation were noted. Application of USI in early terms had allowed to reveal opportunely the disorders of the regenerate formation and to eliminate them using correction of the distraction pace or the method, proposed by the author.

  9. Bifocal Intracranial Germinoma: A Retrospective Analysis of Treatment Outcomes in 20 Patients and Review of the Literature

    SciTech Connect

    Weksberg, David C.; Shibamoto, Yuta; Paulino, Arnold C.

    2012-03-15

    Purpose: Bifocal germinoma (BFG) is a rare intracranial neoplasm for which the choice of radiation therapy (RT) field is controversial. Some believe that BFG represents disseminated disease requiring craniospinal irradiation (CSI), whereas others believe that BFG represents localized disease and advocate for more limited fields. Methods and Materials: We analyzed 20 BFG patients at our institutions with classic bifocal lesions (pineal gland and suprasellar region). In addition, we identified 60 BFG patients from the literature. The RT fields, use of chemotherapy and extent of disease were recorded and analyzed for each patient. Results: There were 55 patients with bifocal lesions only (Group I), and 25 with bifocal lesions plus ventricular and/or CSF positive disease (Group II). The 5-year progression-free survival was 95% for Group I and 80% for Group II. In Group I, there were no failures in patients receiving CSI (n = 11), two spinal failures in those treated with more limited RT fields without chemotherapy (n = 17), and one spinal failure with chemotherapy (n = 23). In Group II, there were no failures in patients receiving CSI (n = 11), but four spinal failures were observed in patients receiving more limited RT fields with chemotherapy (n = 13); 1 patient who received whole-brain RT without chemotherapy experienced failure in the spine and brain. Conclusions: CSI is associated with excellent PFS in BFG. In Group I BFG patients, omission of spinal irradiation appears to be a reasonable approach, especially when chemotherapy is used. Patients with Group II BFG are best treated with CSI.

  10. Comparison of visual outcomes after implantation of diffractive trifocal toric intraocular lens and a diffractive apodized bifocal toric intraocular lens

    PubMed Central

    Gundersen, Kjell Gunnar; Potvin, Rick

    2016-01-01

    Purpose The aim of this study was to compare a new diffractive trifocal toric lens with an apodized diffractive bifocal toric lens in terms of refractive and visual acuity (VA) outcomes, including low-contrast VA (LCVA), as well as the patient’s visual function 3 months after implantation. Patients and methods This is a randomized prospective study involving bilateral implantation of a trifocal toric or a bifocal toric lens. At 3 months postoperatively, the subject’s vision was tested both uncorrected and with his/her best distance correction at: distance (4 m), intermediate (63 cm), and near (40 cm). Binocular defocus curves were measured with no correction and with the subject’s best distance correction in place. Quality of vision was measured using the National Eye Institute Visual Function Questionnaire. Results A total of 22 patients were enrolled (eleven in each group). There was no statistically significant difference in the absolute change in measured rotation between 1 month and 3 months postoperatively between the two intraocular lens (IOL) groups (P=0.98). At 3 months, the postoperative refraction and distance VA by eye were similar between groups. There was no statistically significant difference in the measured LCVA between groups (P=0.39). The defocus curve showed that at 67 cm, the trifocal toric lens had statistically significantly better VA when compared to the bifocal toric lens. There were no statistically significant differences by group for any of the National Eye Institute Visual Function Questionnaire scores (P>0.26 in all cases). Conclusion The trifocal toric IOL improved the intermediate vision without negatively impacting visual function and distance, near, or low-contrast VA when compared to a bifocal toric IOL. The toric component of the trifocal lens effectively reduced astigmatism and provided good rotational stability. PMID:27051269

  11. TOPICAL REVIEW Gravitational lensing

    NASA Astrophysics Data System (ADS)

    Bartelmann, Matthias

    2010-12-01

    Gravitational lensing has developed into one of the most powerful tools for the analysis of the dark universe. This review summarizes the theory of gravitational lensing, its main current applications and representative results achieved so far. It has two parts. In the first, starting from the equation of geodesic deviation, the equations of thin and extended gravitational lensing are derived. In the second, gravitational lensing by stars and planets, galaxies, galaxy clusters and large-scale structures is discussed and summarized.

  12. Fabricating customized hydrogel contact lens

    NASA Astrophysics Data System (ADS)

    Childs, Andre; Li, Hao; Lewittes, Daniella M.; Dong, Biqin; Liu, Wenzhong; Shu, Xiao; Sun, Cheng; Zhang, Hao F.

    2016-10-01

    Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young’s modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies.

  13. Fabricating customized hydrogel contact lens

    PubMed Central

    Childs, Andre; Li, Hao; Lewittes, Daniella M.; Dong, Biqin; Liu, Wenzhong; Shu, Xiao; Sun, Cheng; Zhang, Hao F.

    2016-01-01

    Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young’s modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies. PMID:27748361

  14. Fabricating customized hydrogel contact lens.

    PubMed

    Childs, Andre; Li, Hao; Lewittes, Daniella M; Dong, Biqin; Liu, Wenzhong; Shu, Xiao; Sun, Cheng; Zhang, Hao F

    2016-10-17

    Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young's modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies.

  15. Acquisition Tracking and Pointing Control of the Bifocal Relay Mirror Spacecraft

    NASA Astrophysics Data System (ADS)

    Romano, Marcello; Agrawal, Brij N.

    This spacecraft consists of two large gimbaled telescopes, that are optically coupled and used to redirect a laser beam from a ground-based or spacecraft based source to a distant point on the earth or in space. The attitude control system consists of reaction wheels, star trackers and gyros. The optical control system consists of two fast steering mirrors and two optical tracker sensors. The very tight pointing and jitter requirements, together with the multi-body nature of the spacecraft, make the acquisition, tracking and pointing control very challenging. The control techniques developed in this research can be applied to imaging spacecrafts and spacecrafts with optical communications. numerical simulations. The simulations were performed to analyze two different control approaches proposed for the tracking and pointing of the Bifocal Relay Mirror spacecraft during operational phase. In the first control option considered, feed forward and feedback control are used for the spacecraft attitude control, while independent feedback is used by the optical subsystem in order to compensate the pointing error of the spacecraft. In the second control approach, the spacecraft and optical control systems are integrated. In case of uncertainty in target position and use of realistic sensors, using star tracker and rate gyros with Kalman Filter, the integrated control provides better performance. dynamics and control simulator of the Spacecraft Research and Design Center of Naval Postgraduate School. The attitude of this spherical air bearing based test-bed was controlled by three reaction wheels, while its attitude and angular velocity were sensed by an optical attitude sensor and three rate gyros, respectively. The three axes simulator platform included as payload a fully functional model of the transmitter section of the Bifocal Relay Mirror Spacecraft, consisting in one telescope with fast steering mirror and one optical tracker sensor. Two preliminary experiments have

  16. Microstructure and Hardness Profiles of Bifocal Laser-Welded DP-HSLA Steel Overlap Joints

    NASA Astrophysics Data System (ADS)

    Grajcar, A.; Matter, P.; Stano, S.; Wilk, Z.; Różański, M.

    2017-03-01

    The article presents results related to the bifocal laser welding of overlap joints made of HSLA and DP high-strength steels. The joints were made using a disk laser and a head enabling the 50-50% distribution of laser power. The effects of the laser welding rates and the distance between laser spots on morphological features and hardness profiles were analyzed. It was established that the positioning of beams at angles of 0° or 90° determined the hardness of the individual zones of the joints, without causing significant differences in microstructures of the steels. Microstructural features were inspected using scanning electron microscopy. Both steels revealed primarily martensitic-bainitic microstructures in the fusion zone and in the heat-affected zone. Mixed multiphase microstructures were revealed in the inter-critical heat-affected zone of the joint. The research involved the determination of parameters making it possible to reduce the hardness of joints and prevent the formation of the soft zone in the dual-phase steel.

  17. Fabrication of microlens array and bifocal microlens using the methods of laser ablation and solvent reflow

    NASA Astrophysics Data System (ADS)

    Yu, Cheng-Chian; Ho, Jeng-Rong

    2015-12-01

    Based on the techniques of laser microdrilling and solvent reflow, this study reports on a straightforward approach for fabricating plastic microlens arrays (MLAs). First, we use the ArF excimer laser to drill microholes on a polymethylmethacrylate plate for defining the lens number, initial depth, and diameter. The propylene glycol monomethyl ether acetate solvent is then employed to regulate the surface profile that leads to a resulting negative (concave) MLA. The corresponding positive (convex), polydimethyl-siloxane MLA is obtained by the soft-replica-molding technique. Through varying the pattern size and period on the mask and the light intensity for laser drilling and regulating the solvent in the reflow process, we exhibit the feasibility of making MLAs with various sizes and shapes. By modifying the laser ablation step to drill two microholes with different diameters and depths at two levels, we fabricate a bifocal microlens. The obtained microlenses have excellent surface and optical properties: surface roughness down to several nanometers and focal lengths varying from hundreds to thousands of micrometers. This approach is flexible for constructing microlenses with various sizes and shapes and can fabricate MLAs with a high fill factor.

  18. Terahertz Brewster lenses.

    PubMed

    Wichmann, Matthias; Scherger, Benedikt; Schumann, Steffen; Lippert, Sina; Scheller, Maik; Busch, Stefan F; Jansen, Christian; Koch, Martin

    2011-12-05

    Typical lenses suffer from Fresnel reflections at their surfaces, reducing the transmitted power and leading to interference phenomena. While antireflection coatings can efficiently suppress these reflections for a small frequency window, broadband antireflection coatings remain challenging. In this paper, we report on the simulation and experimental investigation of Brewster lenses in the THz-range. These lenses can be operated under the Brewster angle, ensuring reflection-free transmission of p-polarized light in an extremely broad spectral range. Experimental proof of the excellent focusing capabilities of the Brewster lenses is given by frequency and spatially resolved focus plane measurements using a fiber-coupled THz-TDS system.

  19. Immediate refitting with gas permeable lenses.

    PubMed

    Bennett, E S

    1983-03-01

    Handling long-term polymethylmethacrylate (PMMA) lens wearers, especially those suffering severe corneal oxygen deprivation, has been a problem much relieved by the introduction of oxygen permeable rigid lenses. Previous methods including lens modifications, discontinuation of lens wear, and de-adaptation possessed limitations which could cause the patient to experience permanent corneal curvature and refractive changes. Immediately refitting these patients with gas permeable lenses has been a procedure which appears to have eliminated many of the previous problems and has achieved rapid approval from contact lens practitioners the past few years. This paper discusses how this procedure can be performed to the satisfaction of both the optometrist and the patient.

  20. Bifocal tibial corrective osteotomy with lengthening in achondroplasia: an analysis of results and complications.

    PubMed

    Vaidya, Sandeep V; Song, Hae-Ryong; Lee, Seok-Hyun; Suh, Seung-Woo; Keny, Swapnil M; Telang, Shailendra S

    2006-01-01

    The results and complications of bifocal tibial osteotomies with gradual correction and lengthening by Ilizarov ring fixator performed in 47 tibiae in 24 achondroplastic patients were analyzed. Comparison was made between the parameters of angular and torsional deformities of the tibia preoperatively, at fixator removal, and at last follow-up. Of these parameters, statistically significant change was seen postoperatively in the values of medial proximal tibial angle, lateral distal tibial angle, mechanical axis deviation, and tibial torsion, which changed from 78.8 +/- 7.05 degrees, 103.2 +/- 11.8 degrees, 25.1 +/- 14.6 mm (medial), and 22.7 +/- 10 degrees (internal) preoperatively to 87.3 +/- 6.3 degrees, 90.9 +/- 5.4 degrees, 5.3 +/- 10 cm (medial), and 15.8 +/- 4.2 degrees (external), respectively, at the time of fixator removal; and this correction was maintained during the follow-up period. Mean total tibial lengthening was 6.84 +/- 1.3 cm. Average healing index was 26.06 days/cm. Complications observed were 15 pin tract infections, 1 residual varus, 1 overcorrection into valgus, 2 recurrence of varus, 22 equinus contractures, 2 premature consolidations, and 3 fibula malalignments. Recurrence of varus was observed in limbs with a residual abnormal medial mechanical axis deviation due to femoral deformity. A hundred percent incidence of equinus was observed in limbs with tibial lengthening of more than 40%, with distal tibial lengthening of more than 15%. To minimize the risk for occurrence of equinus, we recommend restriction of distal tibial lengthening in achondroplasia to less than 15%, although total tibial lengthening may exceed 40%. Fibula malalignment was not observed after double fibula osteotomy. This procedure is safe and efficacious if performed with strict adherence to prescribed technique.

  1. Anti-Mastigina activities of eight contact lens solutions.

    PubMed Central

    Niszl, I A; Markus, M B; van Deventer, J M

    1995-01-01

    The effects of eight contact lens solutions on a Mastigina sp., which was associated with the infected eye of a patient, were studied. The solutions which killed the organism promptly were those which are used for gas-permeable and hard contact lenses. Some solutions for soft contact lenses were more effective than others. PMID:8619600

  2. Learning through Different Lenses

    ERIC Educational Resources Information Center

    Jeweler, Sue; Barnes-Robinson, Linda

    2015-01-01

    When parents and teachers help gifted kids use the metaphor "learning through different lenses," amazing things happen: Horizons open up. Ideas are focused. Thoughts are magnified and clarified. They see the big picture. Metaphoric thinking offers new and exciting ways to see the world. Viewing the world through different lenses provides…

  3. One Episode, Two Lenses

    ERIC Educational Resources Information Center

    Drijvers, Paul; Godino, Juan D.; Font, Vicenc; Trouche, Luc

    2013-01-01

    A deep understanding of students' learning processes is one of the core challenges of research in mathematics education. To achieve this, different theoretical lenses are available. The question is how these different lenses compare and contrast, and how they can be coordinated and combined to provide a more comprehensive view on the topic of…

  4. Aspherics in spectacle lenses

    NASA Astrophysics Data System (ADS)

    Dürsteler, Juan Carlos

    2016-12-01

    A review of the use of aspherics in the last decades, understood in a broad sense as encompassing single-vision lenses with conicoid surfaces and free-form and progressive addition lenses (PALs) as well, is provided. The appearance of conicoid surfaces to correct aphakia and later to provide thinner and more aesthetically appealing plus lenses and the introduction of PALs and free-form surfaces have shaped the advances in spectacle lenses in the last three decades. This document basically considers the main target optical aberrations, the idiosyncrasy of single lenses for correction of refractive errors and the restrictions and particularities of PAL design and their links to science vision and perception.

  5. Bifocal metastasis of melanoma to the small intestine from an unknown primary with intestinal obstruction – case report

    PubMed Central

    Bandurski, Jędrzej; Lewandowski, Andrzej

    2013-01-01

    A 64-year-old woman was hospitalized at an internal care unit, due to growing weakness, dizziness, lack of appetite, anemia and abdominal pain. In anamnesis: past myocardial infarction, post-operative hypothyroidism, type 2 diabetes insulin-dependent, stroke, left kidney cirrhosis, gout and anemia. The physical examination did not reveal pathological changes except for skin paleness. The biochemical tests showed iron deficiency anemia and elevated Ca 125 (54.5 U/ml) (normal range: 0.00–35.00). Other markers were normal. An abdominal CT revealed a bifocal infiltration of the small intestine. Due to the increasing obstruction symptoms, the patient was operated on. A bifocal small bowel tumor was found intra-surgically. A partial resection of the jejunum and distal ileum was made. The intestines were joined end to end. The histopathological diagnosis corresponded to metastases of malignant melanoma. The postoperative course was uncomplicated. She received two cycles of dacarbazine 1000 mg/day. Due to drug intolerance, the chemotherapy was discontinued. Now, she is receiving hospice care. PMID:24596522

  6. Twenty years and twenty thousand contact lens patients.

    PubMed Central

    Dixon, J M

    1981-01-01

    A self contained non commercial private office laboratory staffed by office personnel has been used to prepare contact lenses for private office patients. These lenses include hard contact lenses of various materials and various designs. During the past ten years extended wear hydrophilic soft lenses have been prepared in the same manner as hard lenses, all custom made with lens powers, base curves, diameters, and thickness designed according to the needs of each patient. This has provided strict medical supervision and lens maintenance with maximum convenience for patients and the ophthalmologist. Images FIGURE 1 PMID:7342409

  7. Stress-Detection Lenses

    NASA Technical Reports Server (NTRS)

    1996-01-01

    An Ames Research Center scientist invented an infrared lens used in sunglasses to filter out ultraviolet rays. This product finds its origins in research for military enemy detection. Through a Space Act Agreement, Optical Sales Corporation introduced the Hawkeye Lenses not only as sunglasses but as plant stress detection lenses. The lenses enhance the stressed part of the leaf, which has less chlorophyll than healthy leaves, through dyes that filter out certain wavelengths of light. Plant stress is visible earlier, at a stage when something can be done to save the plants.

  8. Acute rigid gas permeable contact lens intolerance.

    PubMed

    Jackson, A J; Wolsley, C; Briggs, J L; Frazer, D G

    2001-01-01

    Rigid gas permeable (RGP) and polymethylmethacrylate (PMMA) lens wearers occasionally report episodes of acute intolerance which is experienced upon lens insertion. In this paper, we report two cases of such intolerance in which the probable cause was contact lens inversion. We also present the results of a study in which a custom-built calibrated strain gauge was used to measure the force in Newtons (N), required to invert RGP lenses [oxygen permeability, or Dk, values between 30 and 90 x 10(-11) (cm2/s) (mlO2/ml x mmHg)] and PMMA lenses of different spherical back vertex powers (+/-3.00 D, 9.00 D). Significantly, less force was required to invert minus powered lenses (17.5 +/- 4.8 N) than plus powered lenses (31.7 +/- 7 .4 N), irrespective of the material. PMMA lenses required more force to induce inversion than that required to invert RGP lenses. Lenses with a Dk of 90 required only two thirds of the force (20.0 +/- 5.8 N) required to cause inversion compared to PMMA lenses (32.9 +/- 11.0 N). High powered PMMA lenses were found to be more likely to fracture on inversion than any other lenses tested. The force required to return negatively powered lenses to their original shape, once inverted, was less than 25% of that initially required to induce inversion. Plus powered lenses either reverted to their original form spontaneously, or required less than 3% of the original inversion force to do so. It was concluded that practitioners should consider inversion as a possible reason for otherwise unexplained, acute RGP contact lens intolerance experienced upon lens insertion. The reason why inversion has eluded so many, as a possible cause of intolerance, is likely to be because minimal force is required to return those lenses, which do not crack or fracture, to their original shape.

  9. Weak Gravitational Lensing

    NASA Astrophysics Data System (ADS)

    Pires, Sandrine; Starck, Jean-Luc; Leonard, Adrienne; Réfrégier, Alexandre

    2012-03-01

    This chapter reviews the data mining methods recently developed to solve standard data problems in weak gravitational lensing. We detail the different steps of the weak lensing data analysis along with the different techniques dedicated to these applications. An overview of the different techniques currently used will be given along with future prospects. Until about 30 years ago, astronomers thought that the Universe was composed almost entirely of ordinary matter: protons, neutrons, electrons, and atoms. The field of weak lensing has been motivated by the observations made in the last decades showing that visible matter represents only about 4-5% of the Universe (see Figure 14.1). Currently, the majority of the Universe is thought to be dark, that is, does not emit electromagnetic radiation. The Universe is thought to be mostly composed of an invisible, pressure less matter - potentially relic from higher energy theories - called "dark matter" (20-21%) and by an even more mysterious term, described in Einstein equations as a vacuum energy density, called "dark energy" (70%). This "dark" Universe is not well described or even understood; its presence is inferred indirectly from its gravitational effects, both on the motions of astronomical objects and on light propagation. So this point could be the next breakthrough in cosmology. Today's cosmology is based on a cosmological model that contains various parameters that need to be determined precisely, such as the matter density parameter Omega_m or the dark energy density parameter Omega_lambda. Weak gravitational lensing is believed to be the most promising tool to understand the nature of dark matter and to constrain the cosmological parameters used to describe the Universe because it provides a method to directly map the distribution of dark matter (see [1,6,60,63,70]). From this dark matter distribution, the nature of dark matter can be better understood and better constraints can be placed on dark energy

  10. Using the Bifocal Modeling Framework to Resolve "Discrepant Events" Between Physical Experiments and Virtual Models in Biology

    NASA Astrophysics Data System (ADS)

    Blikstein, Paulo; Fuhrmann, Tamar; Salehi, Shima

    2016-08-01

    In this paper, we investigate an approach to supporting students' learning in science through a combination of physical experimentation and virtual modeling. We present a study that utilizes a scientific inquiry framework, which we call "bifocal modeling," to link student-designed experiments and computer models in real time. In this study, a group of high school students designed computer models of bacterial growth with reference to a simultaneous physical experiment they were conducting, and were able to validate the correctness of their model against the results of their experiment. Our findings suggest that as the students compared their virtual models with physical experiments, they encountered "discrepant events" that contradicted their existing conceptions and elicited a state of cognitive disequilibrium. This experience of conflict encouraged students to further examine their ideas and to seek more accurate explanations of the observed natural phenomena, improving the design of their computer models.

  11. Extended depth-of-focus 3D micro integral imaging display using a bifocal liquid crystal lens.

    PubMed

    Shen, Xin; Wang, Yu-Jen; Chen, Hung-Shan; Xiao, Xiao; Lin, Yi-Hsin; Javidi, Bahram

    2015-02-15

    We present a three dimensional (3D) micro integral imaging display system with extended depth of focus by using a polarized bifocal liquid crystal lens. This lens and other optical components are combined as the relay optical element. The focal length of the relay optical element can be controlled to project an elemental image array in multiple positions with various lenslet image planes, by applying different voltages to the liquid crystal lens. The depth of focus of the proposed system can therefore be extended. The feasibility of our proposed system is experimentally demonstrated. In our experiments, the depth of focus of the display system is extended from 3.82 to 109.43 mm.

  12. Contact Lens Wear for Visual Disorders in USAF Aviators.

    DTIC Science & Technology

    1986-09-01

    contact lens, Soft contact lens, Keratoconus , Aphakia * ABSTRACT (Contnue on reverse if necessary and identify by block number) ontact lenses are an...and personal protective gear * Specific treatment for certain aedical/optical conditions: keratoconus , irregular astigmatism, aphakia, anisometropia...individuals. Hard lenses were used in 70% of the cases and soft lenses were used in 30Z of the cases. All 13 subjects of the keratoconus cases necessi- tated

  13. Thermal lensing in optical fibers.

    PubMed

    Dong, Liang

    2016-08-22

    Average powers from fiber lasers have reached the point that a quantitative understanding of thermal lensing and its impact on transverse mode instability is becoming critical. Although thermal lensing is well known qualitatively, there is a general lack of a simple method for quantitative analysis. In this work, we first conduct a study of thermal lensing in optical fibers based on a perturbation technique. The perturbation technique becomes increasingly inaccurate as thermal lensing gets stronger. It, however, provides a basis for determining a normalization factor to use in a more accurate numerical study. A simple thermal lensing threshold condition is developed. The impact of thermal lensing on transverse mode instability is also studied.

  14. Contact-eutectic-lens fabrication technique

    NASA Technical Reports Server (NTRS)

    Allen, F. G.; Yue, A. S.; Yu, J. G.

    1975-01-01

    Method enables use of crystal or semiconductor materials with selective spectral-response characteristics (ultraviolet, visible, or infrared wavelengths) in fabrication of contact lenses, reading glasses, and photographic processing equipment.

  15. [Contact lens care and maintenance].

    PubMed

    Bloise, L

    2017-03-29

    All contact lenses with replacement schedules longer than daily must be maintained. At each step of their use, the lenses may be contaminated. Contact lens solutions perform the essential functions of cleaning, decontaminating and preserving the lenses to prevent infectious problems and improve wearing comfort. Contact lens contamination essentially comes from hands, cleaning solutions, cases, water and the environment. The pathogenic microorganisms are mainly Gram-negative bacteria, fungi and amoebae. Contact lens deposits may or may not have an organic origin. Their presence increases the risk of infection because they serve as a nutrient matrix for microbes, and they are responsible for wearing discomfort. Contact lens solutions differ in their composition, their mechanism of action and the concentration of the various agents. To prescribe the best lens care system to each wearer and for each material, it is necessary to be very familiar with them. Maintenance is the main cause of discomfort with contact lenses, either through improper use, solution-material incompatibility, or a reaction of the wearer to the components.

  16. Weak lensing and cosmology

    NASA Astrophysics Data System (ADS)

    Lombardi, Marco; Bertin, Giuseppe

    1999-02-01

    Recently, it has been shown that it is possible to reconstruct the projected mass distribution of a cluster from weak lensing provided that both the geometry of the universe and the probability distribution of galaxy redshifts are known; actually, when additional photometric data are taken to be available, the galaxy redshift distribution could be determined jointly with the cluster mass from the weak lensing analysis. In this paper we develop, in the spirit of a ``thought experiment,'' a method to constrain the geometry of the universe from weak lensing, provided that the redshifts of the source galaxies are measured. The quantitative limits and merits of the method are discussed analytically and with a set of simulations, in relation to point estimation, interval estimation, and test of hypotheses for homogeneous Friedmann-Lema\\^\\i tre models. The constraints turn out to be significant when a few thousand source galaxies are used.

  17. Tear analysis in contact lens wearers.

    PubMed Central

    Farris, R L

    1985-01-01

    Tear analysis in contact lens wearers was compared with tear analysis in aphakics without contact lens wear and normal phakic patients. Subjects were divided into five groups: group 1, aphakic without contact lens; group 2, phakic with daily-wear hard contact lens; group 3, phakic with daily-wear soft contact lens; group 4, phakic with extended-wear soft contact lens; and group 5, aphakic with extended-wear soft contact lens. The experimental groups were compared with age- and sex-matched control groups for statistical analysis of tear variables by means of the Student's t-test. The variables measured were tear osmolarity, tear albumin, and lysozyme and lactoferrin concentrations in basal and reflex tears. Highly significant elevations of tear osmolarity were found in aphakic subjects without contact lenses. Less significant differences in tear osmolarity were found in phakic subjects with hard daily-wear lenses or with extended-wear soft lenses. Tear albumin, lysozyme, and lactoferrin in basal and reflex tears were not significantly different in the different groups of contact lens wearers or in the group of aphakic subjects without contact lenses compared with their control groups. Individual variations in tear albumin, lysozyme, and lactoferrin appeared to be responsible for the inability to demonstrate significant differences in tear composition in association with the wearing of different types of contact lenses. Older and aphakic patients demonstrated a tendency to have increased concentrations of proteins in the tears compared with younger, phakic contact lens wearers and normal controls without contact lenses. PMID:3914131

  18. Are hard lenses superior to soft? Arguments in favor of hard lenses.

    PubMed

    Key, J E

    1990-01-01

    The overriding consideration in choosing between soft contact lenses (SCLs) and rigid gas-permeable (RGP) lenses is the severity of the changes each induces in the corneal epithelium, endothelium, and conjunctival structures. Lens-related epithelial changes are largely the consequence of relative oxygen deprivation and consequent corneal edema. Factors such as lower oxygen transmissibility, minimal tear exchange capacity, and large diameters may explain why SCL wearers show a higher rate of corneal infiltrates, sterile ulcers, and irregular staining patterns than users of RGP lenses. The greater association of hydrogels with infectious keratitis may reflect their tendency to accumulate proteinaceous deposits, harbor bacteria in the polymer matrix, and resist easy disinfection. SCL wear has been linked to endothelial polymegethism, a largely irreversible condition that may cause more rapid corneal swelling and slower deswelling after periods of hypoxic stress. Among the conjunctival problems more often seen in SCL wearers are superficial neovascularization, contact lens-related superior limbic keratoconjunctivitis, and giant papillary conjunctivitis. Mechanical irritation from large-diameter lenses, a tendency to build up mucoproteinaceous deposits, corneal draping, and hypersensitivity to preservatives in SCL care products may play a role in these problems.

  19. Gravitational lensing of gravitational wave

    NASA Astrophysics Data System (ADS)

    Kei Wong, Wang; Ng, Kwan Yeung

    2017-01-01

    Gravitational lensing phenomena are widespread in electromagnetic astrophysics, and in principle may also be uncovered with gravitational waves. We examine gravitational wave events lensed by elliptical galaxies in the limit of geometric optics, where we expect to see multiple signals from the same event with different arrival times and amplitudes. By using mass functions for compact binaries from population-synthesis simulations and a lensing probability calculated from Planck data, we estimate the rate of lensed signals for future gravitational wave missions.

  20. Chromatic confocal microscope using hybrid aspheric diffractive lenses

    NASA Astrophysics Data System (ADS)

    Rayer, Mathieu; Mansfield, Daniel

    2014-05-01

    A chromatic confocal microscope is a single point non-contact distance measurement sensor. For three decades the vast majority of the chromatic confocal microscope use refractive-based lenses to code the measurement axis chromatically. However, such an approach is limiting the range of applications. In this paper the performance of refractive, diffractive and Hybrid aspheric diffractive are compared. Hybrid aspheric diffractive lenses combine the low geometric aberration of a diffractive lens with the high optical power of an aspheric lens. Hybrid aspheric diffractive lenses can reduce the number of elements in an imaging system significantly or create large hyper- chromatic lenses for sensing applications. In addition, diffractive lenses can improve the resolution and the dynamic range of a chromatic confocal microscope. However, to be suitable for commercial applications, the diffractive optical power must be significant. Therefore, manufacturing such lenses is a challenge. We show in this paper how a theoretical manufacturing model can demonstrate that the hybrid aspheric diffractive configuration with the best performances is achieved by step diffractive surface. The high optical quality of step diffractive surface is then demonstrated experimentally. Publisher's Note: This paper, originally published on 5/10/14, was replaced with a corrected/revised version on 5/19/14. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance.

  1. Radiation Blocking Lenses

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Biomedical Optical Company of America's (BOCA) suntiger lenses, similar in principle to natural filters in the eyes of hawks and eagles, bar 99 percent of potentially harmful wavelengths, while allowing visually useful colors of light (red, orange, green) to pass through. They also improve visual acuity, night vision and haze or fog visibility. The lenses evolved from work done by James B. Stephens and Dr. Charles G. Miller of the Jet Propulsion Laboratory. They developed a formula and produced a commercial welding curtain that absorbs, filters, and scatters light. This research led to protective glasses now used by dentists, workers in hazardous environments, CRT operators and skiers.

  2. Weak lensing corrections to tSZ-lensing cross correlation

    SciTech Connect

    Tröster, Tilman; Waerbeke, Ludovic Van E-mail: waerbeke@phas.ubc.ca

    2014-11-01

    The cross correlation between the thermal Sunyaev-Zeldovich (tSZ) effect and gravitational lensing in wide field has recently been measured. It can be used to probe the distribution of the diffuse gas in large scale structure, as well as inform us about the missing baryons. As for any lensing-based quantity, higher order lensing effects can potentially affect the signal. Here, we extend previous higher order lensing calculations to the case of tSZ-lensing cross correlations. We derive terms analogous to corrections due to the Born approximation, lens-lens coupling, and reduced shear up to order ℓ ∼> 3000.

  3. International rigid contact lens prescribing.

    PubMed

    Efron, Nathan; Morgan, Philip B; Helland, Magne; Itoi, Motozumi; Jones, Deborah; Nichols, Jason J; van der Worp, Eef; Woods, Craig A

    2010-06-01

    Rigid lenses have been fitted less since the introduction of soft lenses nearly 40 years ago. Data that we have gathered from annual contact lens fitting surveys conducted in Australia, Canada, Japan, the Netherlands, Norway, the UK and the USA between 2000 and 2008 facilitate an accurate characterization of the pattern of the decline of rigid lens fitting during the first decade of this century. There is a trend for rigid lenses to be utilized primarily for refitting those patients who are already successful rigid lens wearers-most typically older females being refit with higher Dk materials. Rigid lenses are generally fitted on a full-time basis (four or more days of wear per week) without a planned replacement schedule. Orthokeratology is especially popular in the Netherlands, but is seldom prescribed in the other countries surveyed.

  4. Fresnel's Lighthouse Lenses

    ERIC Educational Resources Information Center

    Greenslade, Thomas B., Jr.

    2007-01-01

    One of the rewards of walking up the scores of steps winding around the inside of the shaft of a lighthouse is turning inward and examining the glass optical system. This arrangement of prisms, lenses, and reflectors is used to project the light from a relatively small source in a beam that can be seen far at sea.

  5. Fresnel's Lighthouse Lenses

    NASA Astrophysics Data System (ADS)

    Greenslade, Thomas B.

    2007-12-01

    One of the rewards of walking up the scores of steps winding around the inside of the shaft of a lighthouse is turning inward and examining the glass optical system. This arrangement of prisms, lenses, and reflectors is used to project the light from a relatively small source in a beam that can be seen far at sea.

  6. Weak lensing by voids in modified lensing potentials

    SciTech Connect

    Barreira, Alexandre; Cautun, Marius; Li, Baojiu; Baugh, Carlton M.; Pascoli, Silvia E-mail: m.c.cautun@durham.ac.uk E-mail: c.m.baugh@durham.ac.uk

    2015-08-01

    We study lensing by voids in Cubic Galileon and Nonlocal gravity cosmologies, which are examples of theories of gravity that modify the lensing potential. We find voids in the dark matter and halo density fields of N-body simulations and compute their lensing signal analytically from the void density profiles, which we show are well fit by a simple analytical formula. In the Cubic Galileon model, the modifications to gravity inside voids are not screened and they approximately double the size of the lensing effects compared to GR. The difference is largely determined by the direct effects of the fifth force on lensing and less so by the modified density profiles. For this model, we also discuss the subtle impact on the force and lensing calculations caused by the screening effects of haloes that exist in and around voids. In the Nonlocal model, the impact of the modified density profiles and the direct modifications to lensing are comparable, but they boost the lensing signal by only ≈ 10%, compared with that of GR. Overall, our results suggest that lensing by voids is a promising tool to test models of gravity that modify lensing.

  7. Learning unit: Thin lenses

    NASA Astrophysics Data System (ADS)

    Nita, L.-S.

    2012-04-01

    Learning unit: Thin lenses "Why objects seen through lenses are sometimes upright and sometimes reversed" Nita Laura Simona National College of Arts and Crafts "Constantin Brancusi", Craiova, Romania 1. GEOMETRIC OPTICS. 13 hours Introduction (models, axioms, principles, conventions) 1. Thin lenses (Types of lenses. Defining elements. Path of light rays through lenses. Image formation. Required physical quantities. Lens formulas). 2. Lens systems (Non-collated lenses. Focalless systems). 3. Human eye (Functioning as an optical system. Sight defects and their corrections). 4. Optical instruments (Characteristics exemplified by a magnifying glass. Paths of light rays through a simplified photo camera. Path of light rays through a classical microscope) (Physics curriculum for the IXth grade/ 2011). This scenario exposes a learning unit based on experimental sequences (defining specific competencies), as a succession of lessons started by noticing a problem whose solution assumes the setup of an experiment under laboratory conditions. Progressive learning of theme objectives are realised with sequential experimental steps. The central cognitive process is the induction or the generalization (development of new knowledge based on observation of examples or counterexamples of the concept to be learnt). Pupil interest in theme objectives is triggered by problem-situations, for example: "In order to better see small objects I need a magnifying glass. But when using a magnifier, small object images are sometimes seen upright and sometimes seen reversed!" Along the way, pupils' reasoning will converge to the idea: "The image of an object through a lens depends on the relative distances among object, lens, and observer". Associated learning model: EXPERIMENT Specific competencies: derived from the experiment model, in agreement with the following learning unit steps I. Evoking - Anticipation: Size of the problem, formulation of hypotheses and planning of experiment. II

  8. Tolerancing panoramic lenses

    NASA Astrophysics Data System (ADS)

    Parent, Jocelyn; Thibault, Simon

    2009-08-01

    Tolerancing a lens is a basic procedure in lens design. It consists in first defining an appropriate set of tolerances for the lens, then in adding compensators with their allowable ranges and finally in selecting an appropriate quality criterion (MTF, RMS spot size, wavefront error, boresight error...) for the given application. The procedure is straightforward for standard optical systems. However, it becomes more complex when tolerancing very wide angle lenses (larger than 150 degrees). With a large field of view, issues such as severe off-axis pupil shift, considerable distortion and low relative illumination must be addressed. The pupil shift affects the raytrace as some rays can no longer be traced properly. For high resolution imagers, particularly for robotic and security applications, the image footprint is most critical in order to limit or avoid complex calibration procedures. We studied various wide angle lenses and concluded that most of the distortion comes from the front surface of the lens. Consequently, any variation of the front surface will greatly affect the image footprint. In this paper, we study the effects on the image footprint of slightly modifying the front surface of four different lenses: a simple double-gauss for comparison, a fisheye lens, a catadioptric system (omnidirectional lens) and a Panomorph lens. We also present a method to analyze variations of the image footprint. Our analysis shows that for wide angle lenses, on which the entrance pupil is much smaller than the front surface, irregularities (amplitude, slope and location) are critical on both aspherical and spherical front surfaces to predict the image footprint variation for high resolution cameras. Finally, we present how the entrance pupil varies (location, size) with the field of view for these optical systems.

  9. Bifocal Distraction to Regenerate Segmental Mandibular Defects Using a Custom Made Device: A Report of Two Cases

    PubMed Central

    Krishnan, Sriram; Subramaniam, Ramkumar

    2010-01-01

    Background and objective: Mandibular reconstruction following tumor ablative surgery had been a challenge. It has gone through days of temporary stabilization with k-wire, stainless steel reconstruction plate to avascularized and vascularized bone grafts with varying degree of success and failure. Reconstruction with vascularized bone grafts, though most definitive, requires special expertise, expensive equipment, and long operative time. It also produces donor site morbidity and requires a significant learning curve. With the development of transport distraction techniques there has been a paradigm shift from “reconstructive” to “regenerative” surgery. The objective of this study was to identify the feasibility of an internal device for reconstruction of extensive mandibular defects. Methods and material: This article is to highlight a process of attempted mandibular regeneration in two cases using an indigenously designed distractor device. In individuals with extensive post ablative mandibular defects who were unwilling to have a secondary surgical site or were medically unfit for a long reconstructive procedure, the distraction technique can be used to reconstruct the lost mandibular structures. Conclusion: A satisfactory amount of regenerate was achieved using a bifocal distraction osteogenesis technique for extensive defects of the mandible. The custom made device which was used for this purpose was moderately satisfactory and requires further evaluation and refinement. PMID:22110823

  10. SPT Lensing Likelihood: South Pole Telescope CMB lensing likelihood code

    NASA Astrophysics Data System (ADS)

    Feeney, Stephen M.; Peiris, Hiranya V.; Verde, Licia

    2014-11-01

    The SPT lensing likelihood code, written in Fortran90, performs a Gaussian likelihood based upon the lensing potential power spectrum using a file from CAMB (ascl:1102.026) which contains the normalization required to get the power spectrum that the likelihood call is expecting.

  11. RHIC electron lenses upgrades

    SciTech Connect

    Gu, X.; Altinbas, Z.; Bruno, D.; Binello, S.; Costanzo, M.; Drees, A.; Fischer, W.; Gassner, D. M.; Hock, J.; Hock, K.; Harvey, M.; Luo, Y.; Marusic, A.; Mi, C.; Mernick, K.; Minty, M.; Michnoff, R.; Miller, T. A.; Pikin, A. I.; Robert-Demolaize, G.; Samms, T.; Shrey, T. C.; Schoefer, V.; Tan, Y.; Than, R.; Thieberger, P.; White, S. M.

    2015-05-03

    In the Relativistic Heavy Ion Collider (RHIC) 100 GeV polarized proton run in 2015, two electron lenses were used to partially compensate for the head-on beam-beam effect for the first time. Here, we describe the design of the current electron lens, detailing the hardware modifications made after the 2014 commissioning run with heavy ions. A new electron gun with 15-mm diameter cathode is characterized. The electron beam transverse profile was measured using a YAG screen and fitted with a Gaussian distribution. During operation, the overlap of the electron and proton beams was achieved using the electron backscattering detector in conjunction with an automated orbit control program.

  12. Hollow lensing duct

    DOEpatents

    Beach, Raymond J.; Honea, Eric C.; Bibeau, Camille; Mitchell, Scott; Lang, John; Maderas, Dennis; Speth, Joel; Payne, Stephen A.

    2000-01-01

    A hollow lensing duct to condense (intensify) light using a combination of focusing using a spherical or cylindrical lens followed by reflective waveguiding. The hollow duct tapers down from a wide input side to a narrow output side, with the input side consisting of a lens that may be coated with an antireflective coating for more efficient transmission into the duct. The inside surfaces of the hollow lens duct are appropriately coated to be reflective, preventing light from escaping by reflection as it travels along the duct (reflective waveguiding). The hollow duct has various applications for intensifying light, such as in the coupling of diode array pump light to solid state lasing materials.

  13. Halo-lensing or Self-lensing? Locating the MACHO Lenses

    NASA Astrophysics Data System (ADS)

    Nelson, C. A.; Cook, K. H.; Popowski, P.; Drake, A. J.; Marshall, S. L.; Griest, K.; Vandehei, T.; Alcock, C.; Allsman, R. A.; Axelrod, T. S.; Freeman, K. C.; Peterson, B. A.; Alves, D. R.; Becker, A. C.; Stubbs, C. W.; Tomaney, A. B.; Bennett, D. P.; Geha, M.; Lehner, M. J.; Minniti, D.; Pratt, M. R.; Quinn, P. J.; Sutherland, W.; Welch, D.; MACHO Collaboration

    2000-12-01

    There are two principle geometrical arrangements which may explain Large Magellanic Cloud (LMC) microlensing: a) halo-lensing, in which the lensed object is part of the Milky Way galactic halo and b) self-lensing, in which the lensed object is part of the LMC. Self-lensing in turn may be broken into two categories: LMC-LMC self-lensing, in which both the source and the lens reside in the LMC and background self-lensing, in which the lens is a star in the LMC and the source star is drawn from some population behind the LMC. Models suggest the contribution of LMC-LMC self-lensing is small, so the nature of LMC microlensing may be estimated from the location of the microlensing source stars. If the source stars are in the LMC then microlensing is dominated by halo-lensing; conversely if the source stars are located behind the LMC then microlensing is dominated by self-lensing. Since background populations reside behind the LMC, we expect them to be both redder and fainter then the average population of the LMC. We attempt to determine if the MACHO source stars come from such a background population by comparing the HST color-magnitude diagram (CMD) of source stars to the CMD of the average population of the LMC and looking for the effects of extra reddening and extinction. The microlensing source stars are identified by deriving accurate centroids in the ground-based MACHO images using difference image analysis (DIA) and then transforming the DIA coordinates to the HST frame. Preliminary results suggest that halo-lensing accounts for ≳ 40% of the observed microlensing results. Support provided by NASA, DOE, NSF and NPSC.

  14. Contact dermatitis

    MedlinePlus

    Dermatitis - contact; Allergic dermatitis; Dermatitis - allergic; Irritant contact dermatitis; Skin rash - contact dermatitis ... There are 2 types of contact dermatitis. Irritant dermatitis: This ... can be by contact with acids, alkaline materials such as soaps ...

  15. Laminated Fresnel lenses

    SciTech Connect

    Jebens, R.W.

    1980-04-01

    A fabrication method for making plastic-on-glass laminated Fresnel lenses is discussed. These Fresnel lenses are for application in an RCA solar photovoltaic concentrator array now in the prototype stage of development. This laminated Fresnel lens fabrication method consists of making a Dow Corning J RTV silastic rubber mold of a master lens array. This mold is used to vacuum cast only the lens facets onto a low-iron tempered-glass substrate with an epoxy resin such as Hysol 0S 1000, a bisphenol-A resin with a flexibilizer that is anhydride cured. Cast acrylic Fresnel lens arrays commercialy available have potential cleaning and abrasion problems, have very large thermal expansion, and have dimensional uncertainties in their manufacture. The laminated lens is dimensionally stable with low thermal expansion, has good cleaning characteristics, and is very inexpensive in materials cost. The measured transmission of such a lens on low-iron glass is 80.4% compared with 85.1% for a cast acrylic lens, and the optical quality is good enough for application in the 100X to 200X concentration range. An approach to making large lens arrays (3 by 6 ft) on a commercial scale is explored.

  16. Roulettes: a weak lensing formalism for strong lensing: I. Overview

    NASA Astrophysics Data System (ADS)

    Clarkson, Chris

    2016-08-01

    We present a new perspective on gravitational lensing. We describe a new extension of the weak lensing formalism capable of describing strongly lensed images. By integrating the nonlinear geodesic deviation equation, the amplification matrix of weak lensing is generalised to a sum over independent amplification tensors of increasing rank. We show how an image distorted by a generic lens may be constructed as a sum over ‘roulettes’, which are the natural curves associated with the independent spin modes of the amplification tensors. Highly distorted images can be constructed even for large sources observed near or within the Einstein radius of a lens where the shear and convergence are large. The amplitude of each roulette is formed from a sum over appropriate derivatives of the lensing potential. Consequently, measuring these individual roulettes for images around a lens gives a new way to reconstruct a strong lens mass distribution without requiring a lens model. This formalism generalises the convergence, shear and flexion of weak lensing to arbitrary order, and provides a unified bridge between the strong and weak lensing regimes. This overview paper is accompanied by a much more detailed paper II, arXiv:1603.04652.

  17. Subaru Weak Lensing Measurements of Four Strong Lensing Clusters: Are Lensing Clusters Over-Concentrated?

    SciTech Connect

    Oguri, Masamune; Hennawi, Joseph F.; Gladders, Michael D.; Dahle, Haakon; Natarajan, Priyamvada; Dalal, Neal; Koester, Benjamin P.; Sharon, Keren; Bayliss, Matthew

    2009-01-29

    We derive radial mass profiles of four strong lensing selected clusters which show prominent giant arcs (Abell 1703, SDSS J1446+3032, SDSS J1531+3414, and SDSS J2111-0115), by combining detailed strong lens modeling with weak lensing shear measured from deep Subaru Suprime-cam images. Weak lensing signals are detected at high significance for all four clusters, whose redshifts range from z = 0.28 to 0.64. We demonstrate that adding strong lensing information with known arc redshifts significantly improves constraints on the mass density profile, compared to those obtained from weak lensing alone. While the mass profiles are well fitted by the universal form predicted in N-body simulations of the {Lambda}-dominated cold dark matter model, all four clusters appear to be slightly more centrally concentrated (the concentration parameters c{sub vir} {approx} 8) than theoretical predictions, even after accounting for the bias toward higher concentrations inherent in lensing selected samples. Our results are consistent with previous studies which similarly detected a concentration excess, and increases the total number of clusters studied with the combined strong and weak lensing technique to ten. Combining our sample with previous work, we find that clusters with larger Einstein radii are more anomalously concentrated. We also present a detailed model of the lensing cluster Abell 1703 with constraints from multiple image families, and find the dark matter inner density profile to be cuspy with the slope consistent with -1, in agreement with expectations.

  18. LENSED: a code for the forward reconstruction of lenses and sources from strong lensing observations

    NASA Astrophysics Data System (ADS)

    Tessore, Nicolas; Bellagamba, Fabio; Metcalf, R. Benton

    2016-12-01

    Robust modelling of strong lensing systems is fundamental to exploit the information they contain about the distribution of matter in galaxies and clusters. In this work, we present LENSED, a new code which performs forward parametric modelling of strong lenses. LENSED takes advantage of a massively parallel ray-tracing kernel to perform the necessary calculations on a modern graphics processing unit (GPU). This makes the precise rendering of the background lensed sources much faster, and allows the simultaneous optimization of tens of parameters for the selected model. With a single run, the code is able to obtain the full posterior probability distribution for the lens light, the mass distribution and the background source at the same time. LENSED is first tested on mock images which reproduce realistic space-based observations of lensing systems. In this way, we show that it is able to recover unbiased estimates of the lens parameters, even when the sources do not follow exactly the assumed model. Then, we apply it to a subsample of the Sloan Lens ACS Survey lenses, in order to demonstrate its use on real data. The results generally agree with the literature, and highlight the flexibility and robustness of the algorithm.

  19. Dynamic contour tonometry over silicone hydrogel contact lens

    PubMed Central

    Lam, Andrew K.C.; Tse, Jimmy S.H.

    2013-01-01

    Purpose This study compared the measurements of intraocular pressure (IOP) and ocular pulse amplitude (OPA) using the Dynamic Contour Tonometry (DCT) over silicone hydrogel contact lenses of different modulus. Corneal biomechanics were also measured using the Ocular Response Analyzer (ORA). Methods Forty-seven young (mean age 22.3 years, standard deviation 1.2 years) subjects had IOP, OPA, corneal hysteresis (CH) and corneal resistance factor (CRF) measured without lens and with two brands of silicone hydrogel contact lenses. Each eye wore one brand followed by another, randomly assigned, and then the lenses switched over. Difference and agreement of IOP and OPA with and without silicone hydrogel contact lens were studied. Results The right and left eyes had similar corneal curvatures, central corneal thicknesses, IOP, OPA and corneal biomechanics at baseline. No significant difference was found in CH and CRF when they were measured over different contact lenses. IOP demonstrated a greater difference (95% limits of agreement: 2.73 mmHg) compared with no lens when it was measured over high modulus silicone hydrogel lenses. Agreement improved over low lens modulus silicone hydrogel lenses (95% limits of agreement: 2.2–2.4 mmHg). 95% limits of agreement were within 1.0 mmHg for OPA. Conclusions This study demonstrated the feasibility of DCT over silicone hydrogel lenses. Low lens modulus silicone hydrogel contact lens in situ has no clinical effect on DCT. PMID:24766866

  20. The evolution of lenses.

    PubMed

    Land, Michael F

    2012-11-01

    Structures which bend light and so form images are present in all the major phyla. Lenses with a graded refractive index, and hence reduced spherical aberration, evolved in the vertebrates, arthropods, annelid worms, and several times in the molluscs. Even cubozoan jellyfish have lens eyes. In some vertebrate eyes, multiple focal lengths allow some correction for chromatic aberration. In land vertebrates the cornea took over the main ray-bending task, leaving accommodation as the main function of the lens. The spiders are the only other group to make use of a single cornea as the optical system in their main eyes, and some of these - the salticids - have evolved a remarkable system based on image scanning. Similar scanning arrangements are found in some crustaceans, sea-snails and insect larvae.

  1. Lenses for JWST

    NASA Astrophysics Data System (ADS)

    Ebeling, Harald; Richard, Johan; Kneib, Jean-Paul; Repp, Andrew; Atek, Hakim; Egami, Eiichi; Windhorst, Rogier; Edge, Alastair

    2016-08-01

    JWST will dramatically advance our knowledge and understanding of the first generations of galaxies at z>10, their role in the re-ionization of the Universe, and the evolutionary processes that gave rise to the complexity and diversity of galaxies at the current epoch. As demonstrated by HST legacy projects like CLASH and the Hubble Frontier Fields, gravitational amplification by massive galaxy clusters can significantly extend the depth of the required observations. However, for JWST, reducing any diffuse background light will be just as crucial. We here propose Spitzer/IRAC observations of six massive cluster lenses, specifically selected as candidates for observation with JWST. By (a) quantifying the amount of intra-cluster light and (b) enabling us to improve our current lens models, the data resulting from the requested observations will be instrumental for the final selection of cluster targets that maximize the scientific returns of deep JWST observations.

  2. Pulsar lensing geometry

    NASA Astrophysics Data System (ADS)

    Liu, Siqi; Pen, Ue-Li; Macquart, J.-P.; Brisken, Walter; Deller, Adam

    2016-05-01

    We test the inclined sheet pulsar scintillation model (Pen & Levin) against archival very long baseline interferometry (VLBI) data on PSR 0834+06 and show that its scintillation properties can be precisely reproduced by a model in which refraction occurs on two distinct lens planes. These data strongly favour a model in which grazing-incidence refraction instead of diffraction off turbulent structures is the primary source of pulsar scattering. This model can reproduce the parameters of the observed diffractive scintillation with an accuracy at the percent level. Comparison with new VLBI proper motion results in a direct measure of the ionized interstellar medium (ISM) screen transverse velocity. The results are consistent with ISM velocities local to the PSR 0834+06 sight-line (through the Galaxy). The simple 1-D structure of the lenses opens up the possibility of using interstellar lenses as precision probes for pulsar lens mapping, precision transverse motions in the ISM, and new opportunities for removing scattering to improve pulsar timing. We describe the parameters and observables of this double screen system. While relative screen distances can in principle be accurately determined, a global conformal distance degeneracy exists that allows a rescaling of the absolute distance scale. For PSR B0834+06, we present VLBI astrometry results that provide (for the first time) a direct measurement of the distance of the pulsar. For most of the recycled millisecond pulsars that are the targets of precision timing observations, the targets where independent distance measurements are not available. The degeneracy presented in the lens modelling could be broken if the pulsar resides in a binary system.

  3. Cross-correlating Planck CMB lensing with SDSS: lensing-lensing and galaxy-lensing cross-correlations

    NASA Astrophysics Data System (ADS)

    Singh, Sukhdeep; Mandelbaum, Rachel; Brownstein, Joel R.

    2017-01-01

    We present results from cross-correlating Planck cosmic microwave background (CMB) lensing maps with the Sloan Digital Sky Survey (SDSS) galaxy lensing shape catalogue and BOSS (Baryon Oscillation Spectroscopic Survey) galaxy catalogues. For galaxy position versus CMB lensing cross-correlations, we measure the convergence signal around the galaxies in configuration space, using the BOSS LOWZ (z ˜ 0.30) and CMASS (z ˜ 0.57) samples. With fixed Planck 2015 cosmology, doing a joint fit with the galaxy clustering measurement, for the LOWZ (CMASS) sample we find a galaxy bias bg = 1.75 ± 0.04 (1.95 ± 0.02) and galaxy-matter cross-correlation coefficient rcc = 1.0 ± 0.2 (0.8 ± 0.1) using 20 < rp < 70 h-1 Mpc, consistent with results from galaxy-galaxy lensing. Using the same scales and including the galaxy-galaxy lensing measurements, we constrain Ωm = 0.284 ± 0.024 and relative calibration bias between the CMB lensing and galaxy lensing to be b_γ =0.82^{+0.15}_{-0.14}. The combination of galaxy lensing and CMB lensing also allows us to measure the cosmological distance ratios (with zl ˜ 0.3, zs ˜ 0.5) R=D_s D_{l,*}/D_{* D_{l,s}}=2.68± 0.29, consistent with predictions from the Planck 2015 cosmology (R=2.35). We detect the galaxy position-CMB convergence cross-correlation at small scales, rp < 1 h-1 Mpc, and find consistency with lensing by NFW haloes of mass Mh ˜ 1013 h-1 M⊙. Finally, we measure the CMB lensing-galaxy shear cross-correlation, finding an amplitude of A = 0.76 ± 0.23 (zeff = 0.35, θ < 2°) with respect to Planck 2015 Λ cold dark matter predictions (1σ level consistency). We do not find evidence for relative systematics between the CMB and SDSS galaxy lensing.

  4. Galaxy cluster lensing masses in modified lensing potentials

    SciTech Connect

    Barreira, Alexandre; Li, Baojiu; Jennings, Elise; Merten, Julian; King, Lindsay; Baugh, Carlton M.; Pascoli, Silvia

    2015-10-28

    In this study, we determine the concentration–mass relation of 19 X-ray selected galaxy clusters from the Cluster Lensing and Supernova Survey with Hubble survey in theories of gravity that directly modify the lensing potential. We model the clusters as Navarro–Frenk–White haloes and fit their lensing signal, in the Cubic Galileon and Nonlocal gravity models, to the lensing convergence profiles of the clusters. We discuss a number of important issues that need to be taken into account, associated with the use of non-parametric and parametric lensing methods, as well as assumptions about the background cosmology. Our results show that the concentration and mass estimates in the modified gravity models are, within the error bars, the same as in Λ cold dark matter. This result demonstrates that, for the Nonlocal model, the modifications to gravity are too weak at the cluster redshifts, and for the Galileon model, the screening mechanism is very efficient inside the cluster radius. However, at distances ~ [2–20] Mpc/h from the cluster centre, we find that the surrounding force profiles are enhanced by ~ 20–40% in the Cubic Galileon model. This has an impact on dynamical mass estimates, which means that tests of gravity based on comparisons between lensing and dynamical masses can also be applied to the Cubic Galileon model.

  5. Galaxy cluster lensing masses in modified lensing potentials

    DOE PAGES

    Barreira, Alexandre; Li, Baojiu; Jennings, Elise; ...

    2015-10-28

    In this study, we determine the concentration–mass relation of 19 X-ray selected galaxy clusters from the Cluster Lensing and Supernova Survey with Hubble survey in theories of gravity that directly modify the lensing potential. We model the clusters as Navarro–Frenk–White haloes and fit their lensing signal, in the Cubic Galileon and Nonlocal gravity models, to the lensing convergence profiles of the clusters. We discuss a number of important issues that need to be taken into account, associated with the use of non-parametric and parametric lensing methods, as well as assumptions about the background cosmology. Our results show that the concentrationmore » and mass estimates in the modified gravity models are, within the error bars, the same as in Λ cold dark matter. This result demonstrates that, for the Nonlocal model, the modifications to gravity are too weak at the cluster redshifts, and for the Galileon model, the screening mechanism is very efficient inside the cluster radius. However, at distances ~ [2–20] Mpc/h from the cluster centre, we find that the surrounding force profiles are enhanced by ~ 20–40% in the Cubic Galileon model. This has an impact on dynamical mass estimates, which means that tests of gravity based on comparisons between lensing and dynamical masses can also be applied to the Cubic Galileon model.« less

  6. Galaxy cluster lensing masses in modified lensing potentials

    NASA Astrophysics Data System (ADS)

    Barreira, Alexandre; Li, Baojiu; Jennings, Elise; Merten, Julian; King, Lindsay; Baugh, Carlton M.; Pascoli, Silvia

    2015-12-01

    We determine the concentration-mass relation of 19 X-ray selected galaxy clusters from the Cluster Lensing and Supernova Survey with Hubble survey in theories of gravity that directly modify the lensing potential. We model the clusters as Navarro-Frenk-White haloes and fit their lensing signal, in the Cubic Galileon and Nonlocal gravity models, to the lensing convergence profiles of the clusters. We discuss a number of important issues that need to be taken into account, associated with the use of non-parametric and parametric lensing methods, as well as assumptions about the background cosmology. Our results show that the concentration and mass estimates in the modified gravity models are, within the error bars, the same as in Λ cold dark matter. This result demonstrates that, for the Nonlocal model, the modifications to gravity are too weak at the cluster redshifts, and for the Galileon model, the screening mechanism is very efficient inside the cluster radius. However, at distances ˜(2-20) Mpc h-1 from the cluster centre, we find that the surrounding force profiles are enhanced by ˜20-40 per cent in the Cubic Galileon model. This has an impact on dynamical mass estimates, which means that tests of gravity based on comparisons between lensing and dynamical masses can also be applied to the Cubic Galileon model.

  7. Surface wettability enhancement of silicone hydrogel lenses by processing with polar plastic molds.

    PubMed

    Lai, Y C; Friends, G D

    1997-06-05

    In the quest for hydrogel contact lenses with improved extended wear capability, the use of siloxane moieties in the lens materials was investigated. However, the introduction of hydrophobic siloxane groups gave rise to wettability and lipidlike deposit problems. It was found that when polysiloxane-based compositions for hydrogels were processed with polar plastic molds, such as those fabricated from an acrylonitrile-based polymer, the hydrogel lenses fabricated were wettable, with minimized lipidlike deposits. These findings were supported by the wettability of silicone hydrogel films, silicon, and nitrogen element contents near lens surfaces, as well as the results from clinical assessment of silicone hydrogel lenses.

  8. KINOFORM LENSES - TOWARD NANOMETER RESOLUTION.

    SciTech Connect

    STEIN, A.; EVANS-LUTTERODT, K.; TAYLOR, A.

    2004-10-23

    While hard x-rays have wavelengths in the nanometer and sub-nanometer range, the ability to focus them is limited by the quality of sources and optics, and not by the wavelength. A few options, including reflective (mirrors), diffractive (zone plates) and refractive (CRL's) are available, each with their own limitations. Here we present our work with kinoform lenses which are refractive lenses with all material causing redundant 2{pi} phase shifts removed to reduce the absorption problems inherently limiting the resolution of refractive lenses. By stacking kinoform lenses together, the effective numerical aperture, and thus the focusing resolution, can be increased. The present status of kinoform lens fabrication and testing at Brookhaven is presented as well as future plans toward achieving nanometer resolution.

  9. CMB lensing and giant rings

    SciTech Connect

    Rathaus, Ben; Itzhaki, Nissan E-mail: ben.rathaus@gmail.com

    2012-05-01

    We study the CMB lensing signature of a pre-inationary particle (PIP), assuming it is responsible for the giant rings anomaly that was found recently in the WMAP data. Simulating Planck-like data we find that generically the CMB lensing signal to noise ratio associated with such a PIP is quite small and it would be difficult to cross correlate the temperature giant rings with the CMB lensing signal. However, if the pre-inationary particle is also responsible for the bulk flow measured from the local large scale structure, which happens to point roughly at the same direction as the giant rings, then the CMB lensing signal to noise ratio is fairly significant.

  10. Focus-tunable low-power electrowetting lenses with thin parylene films.

    PubMed

    Watson, Alexander M; Dease, Kevin; Terrab, Soraya; Roath, Christopher; Gopinath, Juliet T; Bright, Victor M

    2015-07-10

    Electrowetting lenses with record low power consumption (microwatts) have been demonstrated using high-quality parylene AF-4 dielectric layers and large dodecyl sulfate ions. Water and propylene glycol are interchanged as the polar liquid to enable diverging and converging lens operation achievable with the application of 15 V. The optical quality of the lenses is comparable to conventional microlenses and the tuning exhibits very little (<0.5°) contact angle hysteresis.

  11. HUBBLE'S TOP TEN GRAVITATIONAL LENSES

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The NASA Hubble Space Telescope serendipitous survey of the sky has uncovered exotic patterns, rings, arcs and crosses that are all optical mirages produced by a gravitational lens, nature's equivalent of having giant magnifying glass in space. Shown are the top 10 lens candidates uncovered in the deepest 100 Hubble fields. Hubble's sensitivity and high resolution allow it to see faint and distant lenses that cannot be detected with ground-based telescopes whose images are blurred by Earth's atmosphere. [Top Left] - HST 01248+0351 is a lensed pair on either side of the edge-on disk lensing galaxy. [Top Center] - HST 01247+0352 is another pair of bluer lensed source images around the red spherical elliptical lensing galaxy. Two much fainter images can be seen near the detection limit which might make this a quadruple system. [Top Right] - HST 15433+5352 is a very good lens candidate with a bluer lensed source in the form of an extended arc about the redder elliptical lensing galaxy. [Middle Far Left] - HST 16302+8230 could be an 'Einstein ring' and the most intriguing lens candidate. It has been nicknamed the 'the London Underground' since it resembles that logo. [Middle Near Left] - HST 14176+5226 is the first, and brightest lens system discovered in 1995 with the Hubble telescope. This lens candidate has now been confirmed spectroscopically using large ground-based telescopes. The elliptical lensing galaxy is located 7 billion light-years away, and the lensed quasar is about 11 billion light-years distant. [Middle Near Right] - HST 12531-2914 is the second quadruple lens candidate discovered with Hubble. It is similar to the first, but appears smaller and fainter. [Middle Far Right] - HST 14164+5215 is a pair of bluish lensed images symmetrically placed around a brighter, redder galaxy. [Bottom Left] - HST 16309+8230 is an edge-on disk-like galaxy (blue arc) which has been significantly distorted by the redder lensing elliptical galaxy. [Bottom Center] - HST 12368

  12. Astrophysical Applications of Gravitational Lensing

    NASA Astrophysics Data System (ADS)

    Mediavilla, Evencio; Muñoz, Jose A.; Garzón, Francisco; Mahoney, Terence J.

    2016-10-01

    Contributors; Participants; Preface; Acknowledgements; 1. Lensing basics Sherry H. Suyu; 2. Exoplanet microlensing Andrew Gould; 3. Case studies of microlensing Veronica Motta and Emilio Falco; 4. Microlensing of quasars and AGN Joachim Wambsganss; 5. DM in clusters and large-scale structure Peter Schneider; 6. The future of strong lensing Chris Fassnacht; 7. Methods for strong lens modelling Charles Keeton; 8. Tutorial on inverse ray shooting Jorge Jimenez-Vicente.

  13. The Thirring-Lense Effect

    NASA Astrophysics Data System (ADS)

    Embacher, Franz

    The Thirring-Lense effect is the phenomenon that an observer near a rotating mass, being in a state which is non-rotating with respect to the rest of the universe, experiences extra inertial forces, i.e. becomes dizzy. The first anticipation of the effect goes back to Ernst Mach; its first quantitative prediction on the basis of general relativity was given by Hans Thirring and Joseph Lense. Almost ninety years later, the effect seems to be experimentally verified.

  14. Solar Photovoltaic Array With Mini-Dome Fresnel Lenses

    NASA Technical Reports Server (NTRS)

    Piszczor, Michael F., Jr.; O'Neill, Mark J.

    1994-01-01

    Mini-dome Fresnel lenses concentrate sunlight onto individual photovoltaic cells. Facets of Fresnel lens designed to refract incident light at angle of minimum deviation to minimize reflective losses. Prismatic cover on surface of each cell reduces losses by redirecting incident light away from metal contacts toward bulk of semiconductor, where it is usefully absorbed. Simple design of mini-dome concentrator array easily adaptable to automated manufacturing techniques currently used by semiconductor industry. Attractive option for variety of future space missions.

  15. Micro-optofluidic Lenses: A review

    PubMed Central

    Nguyen, Nam-Trung

    2010-01-01

    This review presents a systematic perspective on the development of micro-optofluidic lenses. The progress on the development of micro-optofluidic lenses are illustrated by example from recent literature. The advantage of micro-optofluidic lenses over solid lens systems is their tunability without the use of large actuators such as servo motors. Depending on the relative orientation of light path and the substrate surface, micro-optofluidic lenses can be categorized as in-plane or out-of-plane lenses. However, this review will focus on the tunability of the lenses and categorizes them according to the concept of tunability. Micro-optofluidic lenses can be either tuned by the liquid in use or by the shape of the lens. Micro-optofluidic lenses with tunable shape are categorized according to the actuation schemes. Typical parameters of micro-optofluidic lenses reported recently are compared and discussed. Finally, perspectives are given for future works in this field. PMID:20714369

  16. Thermal lensing in ocular media

    NASA Astrophysics Data System (ADS)

    Vincelette, Rebecca Lee

    2009-12-01

    This research was a collaborative effort between the Air Force Research Laboratory (AFRL) and the University of Texas to examine the laser-tissue interaction of thermal lensing induced by continuous-wave, CW, near-infrared, NIR, laser radiation in the eye and its influence on the formation of a retinal lesion from said radiation. CW NIR laser radiation can lead to a thermal lesion induced on the retina given sufficient power and exposure duration as related to three basic parameters; the percent of transmitted energy to, the optical absorption of, and the size of the laser-beam created at the retina. Thermal lensing is a well-known phenomenon arising from the optical absorption, and subsequent temperature rise, along the path of the propagating beam through a medium. Thermal lensing causes the laser-beam profile delivered to the retina to be time dependent. Analysis of a dual-beam, multidimensional, high-frame rate, confocal imaging system in an artificial eye determined the rate of thermal lensing in aqueous media exposed to 1110, 1130, 1150 and 1318-nm wavelengths was related to the power density created along the optical axis and linear absorption coefficient of the medium. An adaptive optics imaging system was used to record the aberrations induced by the thermal lens at the retina in an artificial eye during steady-state. Though the laser-beam profiles changed over the exposure time, the CW NIR retinal damage thresholds between 1110--1319-nm were determined to follow conventional fitting algorithms which neglected thermal lensing. A first-order mathematical model of thermal lensing was developed by conjoining an ABCD beam propagation method, Beer's law of attenuation, and a solution to the heat-equation with respect to radial diffusion. The model predicted that thermal lensing would be strongest for small (< 4-mm) 1/e2 laser-beam diameters input at the corneal plane and weakly transmitted wavelengths where less than 5% of the energy is delivered to the retina

  17. Breeding gravitational lenses

    NASA Astrophysics Data System (ADS)

    Liesenborgs, J.; de Rijcke, S.; Dejonghe, H.; Bekaert, P.

    2011-03-01

    Gravitational lenses are a spectacular astrophysical phenomenon, a cosmic mirage caused by the gravitational deflection of light in which multiple images of a same background object can be seen. Their beauty is only exceeded by their usefulness, as the gravitational lens effect is a direct probe of the total mass of the deflecting object. Furthermore, since the image configuration arising from the gravitational lens effect depends on the exact gravitational potential of the deflector, it even holds the promise of learning about the distribution of the mass. In this presentation, a method for extracting the information encoded in the images and reconstructing the mass distribution is presented. Being a non-parametric method, it avoids making a priori assumptions about the shape of the mass distribution. At the core of the procedure lies a genetic algorithm, an optimization strategy inspired by Darwin's principle of ``survival of the fittest''. One only needs to specify a criterion to decide if one particular trial solution is deemed better than another, and the genetic algorithm will ``breed'' appropriate solutions to the problem. In a similar way, one can create a multi-objective genetic algorithm, capable of optimizing several fitness criteria at the same time. This provides a very flexible way to incorporate all the available information in the gravitational lens system: not only the positions and shapes of the multiple images are used, but also the so-called ``null space'', i.e. the area in which no such images can be seen. The effectiveness of this approach is illustrated using simulated data, which allows one to compare the reconstruction to the true mass distribution.

  18. Cosmology with weak lensing surveys.

    PubMed

    Munshi, Dipak; Valageas, Patrick

    2005-12-15

    Weak gravitational lensing is responsible for the shearing and magnification of the images of high-redshift sources due to the presence of intervening mass. Since the lensing effects arise from deflections of the light rays due to fluctuations of the gravitational potential, they can be directly related to the underlying density field of the large-scale structures. Weak gravitational surveys are complementary to both galaxy surveys and cosmic microwave background observations as they probe unbiased nonlinear matter power spectra at medium redshift. Ongoing CMBR experiments such as WMAP and a future Planck satellite mission will measure the standard cosmological parameters with unprecedented accuracy. The focus of attention will then shift to understanding the nature of dark matter and vacuum energy: several recent studies suggest that lensing is the best method for constraining the dark energy equation of state. During the next 5 year period, ongoing and future weak lensing surveys such as the Joint Dark Energy Mission (JDEM; e.g. SNAP) or the Large-aperture Synoptic Survey Telescope will play a major role in advancing our understanding of the universe in this direction. In this review article, we describe various aspects of probing the matter power spectrum and the bi-spectrum and other related statistics with weak lensing surveys. This can be used to probe the background dynamics of the universe as well as the nature of dark matter and dark energy.

  19. Surface gravity-wave lensing.

    PubMed

    Elandt, Ryan B; Shakeri, Mostafa; Alam, Mohammad-Reza

    2014-02-01

    Here we show that a nonlinear resonance between oceanic surface waves caused by small seabed features (the so-called Bragg resonance) can be utilized to create the equivalent of lenses and curved mirrors for surface gravity waves. Such gravity wave lenses, which are merely small changes to the seafloor topography and therefore are surface noninvasive, can focus or defocus the energy of incident waves toward or away from any desired focal point. We further show that for a broadband incident wave spectrum (i.e., a wave group composed of a multitude of different-frequency waves), a polychromatic topography (occupying no more than the area required for a monochromatic lens) can achieve a broadband lensing effect. Gravity wave lenses can be utilized to create localized high-energy wave zones (e.g., for wave energy harvesting or creating artificial surf zones) as well as to disperse waves in order to create protected areas (e.g., harbors or areas near important offshore facilities). In reverse, lensing of oceanic waves may be caused by natural seabed features and may explain the frequent appearance of very high amplitude waves in certain bodies of water.

  20. The M31 pixel lensing plan campaign: MACHO lensing and self-lensing signals

    SciTech Connect

    Calchi Novati, S.; Scarpetta, G.; Bozza, V.; Bruni, I.; Gualandi, R.; Dall'Ora, M.; De Paolis, F.; Ingrosso, G.; Nucita, A.; Strafella, F.; Dominik, M.; Jetzer, Ph.; Mancini, L.; Safonova, M.; Subramaniam, A.; Sereno, M.; Gould, A.; Collaboration: PLAN Collaboration

    2014-03-10

    We present the final analysis of the observational campaign carried out by the PLAN (Pixel Lensing Andromeda) collaboration to detect a dark matter signal in form of MACHOs through the microlensing effect. The campaign consists of about 1 month/year observations carried out over 4 years (2007-2010) at the 1.5 m Cassini telescope in Loiano (Astronomical Observatory of BOLOGNA, OAB) plus 10 days of data taken in 2010 at the 2 m Himalayan Chandra Telescope monitoring the central part of M31 (two fields of about 13' × 12.'6). We establish a fully automated pipeline for the search and the characterization of microlensing flux variations. As a result, we detect three microlensing candidates. We evaluate the expected signal through a full Monte Carlo simulation of the experiment completed by an analysis of the detection efficiency of our pipeline. We consider both 'self lensing' and 'MACHO lensing' lens populations, given by M31 stars and dark matter halo MACHOs, in M31 and the Milky Way, respectively. The total number of events is consistent with the expected self-lensing rate. Specifically, we evaluate an expected signal of about two self-lensing events. As for MACHO lensing, for full 0.5(10{sup –2}) M {sub ☉} MACHO halos, our prediction is for about four (seven) events. The comparatively small number of expected MACHO versus self-lensing events, together with the small number statistics at our disposal, do not enable us to put strong constraints on that population. Rather, the hypothesis, suggested by a previous analysis, on the MACHO nature of OAB-07-N2, one of the microlensing candidates, translates into a sizeable lower limit for the halo mass fraction in form of the would-be MACHO population, f, of about 15% for 0.5 M {sub ☉} MACHOs.

  1. Fabrication of Adhesive Lenses Using Free Surface Shaping

    NASA Astrophysics Data System (ADS)

    Hoheisel, D.; Kelb, C.; Wall, M.; Roth, B.; Rissing, L.

    2013-09-01

    Two approaches for fabricating polymer lenses are presented in this paper. Both are based on filling circular holes with UV curing adhesives. Initially, the viscous adhesive material creates a liquid and spherical free surface due to its own surface tension. This shape is then preserved by curing with UV-hardening light. For the first approach, the holes are generated in a 4 inch Si-wafer by deep reactive ion etching (DRIE) and for the second, a polydimethylsiloxane (PDMS) mould is manufactured. Three types of UV-curing adhesives are investigated (NOA 61, NOA 88 and NEA 121 by Norland Products). Preliminary to the determination of the lens curvature, a contact angle goniometer is used for taking side view images of the lenses. The radius of curvature is then extracted via image processing with the software MATLAB®. Furthermore, the surface roughness of the PDMS mould and the generated lenses is measured with a white light interferometer to characterize the casting process. The resolution power of the generated lenses is evaluated by measurement of their point spread functions (psf) and modulation transfer functions (mtf), respectively.

  2. Quantification of individual proteins in silicone hydrogel contact lens deposits

    PubMed Central

    Zhao, Zhenjun; Zhu, Hua; Tilia, Daniel; Willcox, Mark D.P.

    2013-01-01

    Purpose The aim of this study was to quantify specific proteins deposited on daily wear silicone hydrogel lenses used in combination with multipurpose disinfecting solutions (MPDSs) by applying multiple-reaction-monitoring mass spectrometry (MRM-MS). Methods Balafilcon A or senofilcon A contact lenses used with different MPDSs on a daily wear schedule were collected. Each worn lens was extracted and then digested with trypsin. MRM-MS was applied to quantify the amounts of lysozyme, lactoferrin, lipocalin-1, proline-rich protein-4, and keratin-1 in the extracts. Results The amount of protein extracted from the contact lenses was affected by the individual wearers, lens material, and type of care system used. Higher amounts of proteins were extracted from lenses after wear when they were used with an MPDS containing polyhexamethylene biguanide (PHMB) and poloxamer 407 compared with MPDSs containing polyquaternium-1 (PQ-1)/alexidine dihydrochloride with Tetronic 904 or PQ-1/ PHMB with poloxamine and sulfobetaine (p<0.05). There was a correlation between the amount of lipocalin-1 or keratin-1 extracted from lenses and symptoms of ocular dryness. Conclusions The MRM-MS technique is a promising approach that could be used to reveal associations of individual proteins deposited on lenses with performance of contact lenses during wear. PMID:23441110

  3. Lensing smoothing of BAO wiggles

    NASA Astrophysics Data System (ADS)

    Di Dio, Enea

    2017-03-01

    We study non-perturbatively the effect of the deflection angle on the BAO wiggles of the matter power spectrum in real space. We show that from redshift z~2 this introduces a dispersion of roughly 1 Mpc at BAO scale, which corresponds approximately to a 1% effect. The lensing effect induced by the deflection angle, which is completely geometrical and survey independent, smears out the BAO wiggles. The effect on the power spectrum amplitude at BAO scale is about 0.1 % for z~2 and 0.2 % for z~4. We compare the smoothing effects induced by the lensing potential and non-linear structure formation, showing that the two effects become comparable at z ~ 4, while the lensing effect dominates for sources at higher redshifts. We note that this effect is not accounted through BAO reconstruction techniques.

  4. Beam bending via plasmonic lenses.

    PubMed

    Zhao, Yanhui; Lin, Sz-Chin Steven; Nawaz, Ahmad Ahsan; Kiraly, Brian; Hao, Qingzhen; Liu, Yanjun; Huang, Tony Jun

    2010-10-25

    We have designed and characterized three different types of plasmonic lenses that cannot only focus, but can also bend electromagnetic (EM) waves. The bending effect is achieved by constructing an asymmetric phase front caused by varying phase retardations in EM waves as they pass through a plasmonic lens. With an incident wave normal to the lens surface, light bends up to 8° off the axial direction. The optical wave propagation was numerically investigated using the finite-difference time-domain (FDTD) method. Simulation results show that the proposed plasmonic lenses allow effective beam bending under both normal and tilted incidence. With their relatively large bending range and capability to perform in the far field, the plamsonic lenses described in this article could be valuable in applications such as photonic communication and plasmonic circuits.

  5. Tuning Gravitationally Lensed Standard Sirens

    NASA Astrophysics Data System (ADS)

    Jönsson, J.; Goobar, A.; Mörtsell, E.

    2007-03-01

    Gravitational waves emitted by chirping supermassive black hole binaries could in principle be used to obtain very accurate distance determinations. Provided they have an electromagnetic counterpart from which the redshift can be determined, these standard sirens could be used to build a high-redshift Hubble diagram. Errors in the distance measurements will most likely be dominated by gravitational lensing. We show that the (de)magnification due to inhomogeneous foreground matter will increase the scatter in the measured distances by a factor of ~10. We propose to use optical and IR data of the foreground galaxies to minimize the degradation from weak lensing. We find that the net effect of correcting the estimated distances for lensing is comparable to increasing the sample size by a factor of 3 when using the data to constrain cosmological parameters.

  6. Contact lens fitting after photorefractive keratectomy.

    PubMed Central

    Astin, C. L.; Gartry, D. S.; McG Steele, A. D.

    1996-01-01

    AIMS/BACKGROUND: This study evaluated contact lens fitting and the longer term response of the photorefractive keratectomy (PRK) cornea to lens wear. In PRK for myopia problems such as regression, anterior stromal haze, irregular astigmatism, halo aberration, and anisometropia have been reported. Certain patients therefore require contact lens correction to obtain best corrected visual acuity (BCVA). METHOD: From an original cohort of 80 patients, 15 were dissatisfied with their visual outcome 6 months after PRK. Ten of these were fitted with lenses and monitored regularly. RESULTS: The best fit rigid gas permeable lens of diameter 9.20-10.00 mm was generally 0.10 mm steeper than mean keratometry readings. Because of lid discomfort five patients were refitted with daily wear soft lenses. All 10 achieved satisfactory lens wear of 10 hours per day. Central corneal steepening of 0.75 D (0.15 mm) occurred in one patient. Two patients had slight central corneal flattening. Three patients discontinued lens wear as they found lens care a nuisance. Four finally opted for retreatment by PRK. CONCLUSIONS: In most cases, contact lenses gave good visual acuity and, in cases of mild irregular astigmatism, a significant improvement over spectacle BCVA. No significant adverse reaction to contact lens wear was found. Although ocular tolerance of lenses was satisfactory, several patients discontinued lens wear or sought improved unaided vision. Images PMID:8795370

  7. What To Know If Your Child Wants Contact Lenses

    MedlinePlus

    ... Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products For Consumers Home For Consumers ... Safer Spring Break More in Consumer Updates Animal & Veterinary Children's Health Cosmetics Dietary Supplements Drugs Food Medical ...

  8. Fabrication of nanoscale electrostatic lenses

    NASA Astrophysics Data System (ADS)

    Sinno, I.; Sanz-Velasco, A.; Kang, S.; Jansen, H.; Olsson, E.; Enoksson, P.; Svensson, K.

    2010-09-01

    The fabrication of cylindrical multi-element electrostatic lenses at the nanoscale presents a challenge; they are high-aspect-ratio structures that should be rotationally symmetric, well aligned and freestanding, with smooth edges and flat, clean surfaces. In this paper, we present the fabrication results of a non-conventional process, which uses a combination of focused gallium ion-beam milling and hydrofluoric acid vapor etching. This process makes it possible to fabricate nanoscale electrostatic lenses down to 140 nm in aperture diameter and 4.2 µm in column length, with a superior control of the geometry as compared to conventional lithography-based techniques.

  9. Success of hydrocone (TORIS-K) soft contact lens for keratoconus and traumatic keratopathy

    PubMed Central

    Altun, Ahmet; Kurna, Sevda Aydin; Sengor, Tomris; Altun, Gulengul; Olcaysu, Osman Okan; Simsek, Mert Hakan

    2015-01-01

    Objective: To present success of Toris-K contact lenses in keratoconus and traumatic keratopathy with irregular corneal surface. Methods: Toris-K contact lenses were used to treat 7 eyes of 4 patients with traumatic keratopathy (Case 1) or keratoconus (Case 2, Case 3, and Case 4). All cases had a complete eye examination before the contact lens application. The case with traumatic keratopathy was a 32-year-old male who had corneal penetrating injury due to hobnail strike 23 months ago. The other 3 keratoconus cases were females at the age of 14, 16 and 22 years old. They had high myopia and irregular astigmatism due to keratoconus. All patients refused using rigid gas permeable contact lens because of intolerance. Toris-K contact lenses were fitted on all eyes. All patients were followed-up for 28 months with a complete ophthalmic examination and corneal topography every two months. Results: Improvement of BCVA of the cases was remarkable. All cases were comfortable with their Toris-K contact lenses for 28 months. There was no significant distortion on the lenses during follow-up period. Conclusion: Toris-K lenses may be an effective alternative treatment option for the patients with keratoconus and traumatic keratopathy, especially who cannot tolerate rigid gas permeable contact lenses. PMID:26430446

  10. Peripheral Aberrations and Image Quality for Contact Lens Correction

    PubMed Central

    Shen, Jie; Thibos, Larry N.

    2011-01-01

    Purpose Contact lenses reduced the degree of hyperopic field curvature present in myopic eyes and rigid contact lenses reduced sphero-cylindrical image blur on the peripheral retina, but their effect on higher order aberrations and overall optical quality of the eye in the peripheral visual field is still unknown. The purpose of our study was to evaluate peripheral wavefront aberrations and image quality across the visual field before and after contact lens correction. Methods A commercial Hartmann-Shack aberrometer was used to measure ocular wavefront errors in 5° steps out to 30° of eccentricity along the horizontal meridian in uncorrected eyes and when the same eyes are corrected with soft or rigid contact lenses. Wavefront aberrations and image quality were determined for the full elliptical pupil encountered in off-axis measurements. Results Ocular higher-order aberrations increase away from fovea in the uncorrected eye. Third-order aberrations are larger and increase faster with eccentricity compared to the other higher-order aberrations. Contact lenses increase all higher-order aberrations except 3rd-order Zernike terms. Nevertheless, a net increase in image quality across the horizontal visual field for objects located at the foveal far point is achieved with rigid lenses, whereas soft contact lenses reduce image quality. Conclusions Second order aberrations limit image quality more than higher-order aberrations in the periphery. Although second-order aberrations are reduced by contact lenses, the resulting gain in image quality is partially offset by increased amounts of higher-order aberrations. To fully realize the benefits of correcting higher-order aberrations in the peripheral field requires improved correction of second-order aberrations as well. PMID:21873925

  11. 21 CFR 800.12 - Contact lens solutions and tablets; tamper-resistant packaging.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Contact lens solutions and tablets; tamper....12 Contact lens solutions and tablets; tamper-resistant packaging. (a) General. Unless contact lens solutions used, for example, to clean, disinfect, wet, lubricate, rinse, soak, or store contact lenses...

  12. 21 CFR 800.12 - Contact lens solutions and tablets; tamper-resistant packaging.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Contact lens solutions and tablets; tamper....12 Contact lens solutions and tablets; tamper-resistant packaging. (a) General. Unless contact lens solutions used, for example, to clean, disinfect, wet, lubricate, rinse, soak, or store contact lenses...

  13. 21 CFR 800.12 - Contact lens solutions and tablets; tamper-resistant packaging.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Contact lens solutions and tablets; tamper....12 Contact lens solutions and tablets; tamper-resistant packaging. (a) General. Unless contact lens solutions used, for example, to clean, disinfect, wet, lubricate, rinse, soak, or store contact lenses...

  14. 21 CFR 800.12 - Contact lens solutions and tablets; tamper-resistant packaging.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Contact lens solutions and tablets; tamper....12 Contact lens solutions and tablets; tamper-resistant packaging. (a) General. Unless contact lens solutions used, for example, to clean, disinfect, wet, lubricate, rinse, soak, or store contact lenses...

  15. 21 CFR 800.12 - Contact lens solutions and tablets; tamper-resistant packaging.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Contact lens solutions and tablets; tamper....12 Contact lens solutions and tablets; tamper-resistant packaging. (a) General. Unless contact lens solutions used, for example, to clean, disinfect, wet, lubricate, rinse, soak, or store contact lenses...

  16. Lensing signals from spin-2 perturbations

    SciTech Connect

    Adamek, Julian; Durrer, Ruth; Tansella, Vittorio E-mail: ruth.durrer@unige.ch

    2016-01-01

    We compute the angular power spectra of the E-type and B-type lensing potentials for gravitational waves from inflation and for tensor perturbations induced by scalar perturbations. We derive the tensor-lensed CMB power spectra for both cases. We also apply our formalism to determine the linear lensing potential for a Bianchi I spacetime with small anisotropy.

  17. N-body lensed CMB maps: lensing extraction and characterization

    NASA Astrophysics Data System (ADS)

    Antolini, Claudia; Fantaye, Yabebal; Martinelli, Matteo; Carbone, Carmelita; Baccigalupi, Carlo

    2014-02-01

    We reconstruct shear maps and angular power spectra from simulated weakly lensed total intensity (TT) and polarised (EB) maps of the Cosmic Microwave Background (CMB) anisotropies, obtained using Born approximated ray-tracing through the N-body simulated Cold Dark Matter (CDM) structures in the Millennium Simulations (MS). We compare the recovered signal with the ΛCDM prediction, on the whole interval of angular scales which is allowed by the finite box size, extending from the degree scale to the arcminute, by applying a quadratic estimator in the flat sky limit; we consider PRISM-like instrumental specification for future generation CMB satellites, corresponding to arcminute angular resolution of 3.2' and sensitivity of 2.43 μK-arcmin. The noise contribution in the simulations closely follows the estimator prediction, becoming dominated by limits in the angular resolution for the EB signal, at l simeq 1500. The recovered signal shows no visible departure from predictions of the weak lensing power within uncertainties, when considering TT and EB data singularly. In particular, the reconstruction precision reaches the level of a few percent in bins with Δl simeq 100 in the angular multiple interval 1000lesssimllesssim2000 for T, and about 10% for EB. Within the adopted specifications, polarisation data do represent a significant contribution to the lensing shear, which appear to faithfully trace the underlying N-body structure down to the smallest angular scales achievable with the present setup, validating at the same time the latter with respect to semi-analytical predictions from ΛCDM cosmology at the level of CMB lensing statistics. This work demonstrates the feasibility of CMB lensing studies based on large scale simulations of cosmological structure formation in the context of the current and future high resolution and sensitivity CMB experiment.

  18. N-body lensed CMB maps: lensing extraction and characterization

    SciTech Connect

    Antolini, Claudia; Martinelli, Matteo; Baccigalupi, Carlo; Fantaye, Yabebal; Carbone, Carmelita E-mail: y.t.fantaye@astro.uio.no E-mail: carmelita.carbone@brera.inaf.it

    2014-02-01

    We reconstruct shear maps and angular power spectra from simulated weakly lensed total intensity (TT) and polarised (EB) maps of the Cosmic Microwave Background (CMB) anisotropies, obtained using Born approximated ray-tracing through the N-body simulated Cold Dark Matter (CDM) structures in the Millennium Simulations (MS). We compare the recovered signal with the ΛCDM prediction, on the whole interval of angular scales which is allowed by the finite box size, extending from the degree scale to the arcminute, by applying a quadratic estimator in the flat sky limit; we consider PRISM-like instrumental specification for future generation CMB satellites, corresponding to arcminute angular resolution of 3.2' and sensitivity of 2.43 μK-arcmin. The noise contribution in the simulations closely follows the estimator prediction, becoming dominated by limits in the angular resolution for the EB signal, at ℓ ≅ 1500. The recovered signal shows no visible departure from predictions of the weak lensing power within uncertainties, when considering TT and EB data singularly. In particular, the reconstruction precision reaches the level of a few percent in bins with Δℓ ≅ 100 in the angular multiple interval 1000∼<ℓ∼<2000 for T, and about 10% for EB. Within the adopted specifications, polarisation data do represent a significant contribution to the lensing shear, which appear to faithfully trace the underlying N-body structure down to the smallest angular scales achievable with the present setup, validating at the same time the latter with respect to semi-analytical predictions from ΛCDM cosmology at the level of CMB lensing statistics. This work demonstrates the feasibility of CMB lensing studies based on large scale simulations of cosmological structure formation in the context of the current and future high resolution and sensitivity CMB experiment.

  19. A Drug-Eluting Contact Lens

    PubMed Central

    Ciolino, Joseph B.; Hoare, Todd R.; Iwata, Naomi G.; Behlau, Irmgard; Dohlman, Claes H.; Langer, Robert; Kohane, Daniel S.

    2014-01-01

    Purpose To formulate and characterize a drug-eluting contact lens designed to provide extended, controlled release of a drug. Methods Prototype contact lenses were created by coating PLGA (poly[lactic-co-glycolic acid]) films containing test compounds with pHEMA (poly[hydroxyethyl methacrylate]) by ultraviolet light polymerization. The films, containing encapsulated fluorescein or ciprofloxacin, were characterized by scanning electron microscopy. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. Ciprofloxacin eluted from the contact lens was studied in an antimicrobial assay to verify antimicrobial effectiveness. Results After a brief and minimal initial burst, the prototype contact lenses demonstrated controlled release of the molecules studied, with zero-order release kinetics under infinite sink conditions for over 4 weeks. The rate of drug release was controlled by changing either the ratio of drug to PLGA or the molecular mass of the PLGA used. Both the PLGA and the pHEMA affected release kinetics. Ciprofloxacin released from the contact lenses inhibited ciprofloxacin-sensitive Staphylococcus aureus at all time-points tested. Conclusions A prototype contact lens for sustained drug release consisting of a thin drug-PLGA film coated with pHEMA could be used as a platform for ocular drug delivery with widespread therapeutic applications. PMID:19136709

  20. Swelling and deswelling of rabbit corneas in response to rigid gas permeable, hydrogel and elastomer contact lens wear.

    PubMed

    Hideji, I; MacKeen, D L; Hamano, H; Jester, J V; Cavanagh, H D

    1989-01-01

    We determined diurnal variation in corneal thickness in rabbits prior to and following overnight wear of: (i) selected rigid contact lenses with different Dk values; (ii) hydrogel lenses of low and high water content; and (iii) elastomer lenses. The degree of contact lens-induced corneal swelling observed during 24 hours of lens wear, and the rates of deswelling in the subsequent 24 hours, correlated well with the different oxygen transmissibilities of the individual RGP contact lenses. The greatest swelling (21.6 +/- 5.4%) followed the wear of PMMA lenses. The least swelling, 2.9 +/- 4.0%, followed the wear of rigid gas permeable (RGP) Menicon SF-P (melafocon A) lenses, a value nearly identical to the swelling observed in the morning following sleep without lenses, (0.0 +/- 3.1%). By contrast, low-water content hydrogel soft contact lens use was associated with drastic corneal deswelling rates (-15.1 +/- 4.5%) during the hours after lens wear. The difference between these and control corneas was significant by paired t-test (P less than 0.01). Eyes wearing high water content lenses had less deswelling than eyes with their low-water counterparts. Corneal swelling produced by elastomer lenses was similar to that seen with RGP lenses.

  1. High Dk piggyback contact lens system for contact lens-intolerant keratoconus patients

    PubMed Central

    Sengor, Tomris; Kurna, Sevda Aydin; Aki, Suat; Özkurt, Yelda

    2011-01-01

    Background: The aim of the study was to examine the clinical success of high Dk (oxygen permeability) piggyback contact lens (PBCL) systems for the correction of contact lens intolerant keratoconus patients. Methods: Sixteen patients (29 eyes) who were not able to wear gas-permeable rigid lenses were included in this study. Hyper Dk silicone hydrogel (oxygen transmissibility or Dk/t = 150 units) and fluorosilicone methacrylate copolymer (Dk/t = 100 units) lenses were chosen as the PBCL systems. The clinical examinations included visual acuity and corneal observation by biomicroscopy, keratometer reading, and fluorescein staining before and after fitting the PBCL system. Results: Indications for using PBCL system were: lens stabilization and comfort, improving comfort, and adding protection to the cone. Visual acuities increased significantly in all of the patients compared with spectacles (P = 0). Improvement in visual acuity compared with rigid lenses alone was recorded in 89.7% of eyes and no alteration of the visual acuity was observed in 10.3% of the eyes. Wearing time of PBCL systems for most of the patients was limited time (mean 6 months, range 3–12 months); thereafter they tolerated rigid lenses alone except for 2 patients. Conclusion: The PBCL system is a safe and effective method to provide centering and corneal protection against mechanical trauma by the rigid lenses for keratoconus patients and may increase contact lens tolerance. PMID:21468342

  2. Optics Demonstrations Using Cylindrical Lenses

    ERIC Educational Resources Information Center

    Ivanov, Dragia; Nikolov, Stefan

    2015-01-01

    In this paper we consider the main properties of cylindrical lenses and propose several demonstrational experiments that can be performed with them. Specifically we use simple glasses full of water to demonstrate some basic geometrical optics principles and phenomena. We also present some less standard experiments that can be performed with such…

  3. Towards noiseless gravitational lensing simulations

    NASA Astrophysics Data System (ADS)

    Angulo, Raul E.; Chen, Ruizhu; Hilbert, Stefan; Abel, Tom

    2014-11-01

    The microphysical properties of the dark matter (DM) particle can, in principle, be constrained by the properties and abundance of substructures in galaxy clusters, as measured through strong gravitational lensing. Unfortunately, there is a lack of accurate theoretical predictions for the lensing signal of these substructures, mainly because of the discreteness noise inherent to N-body simulations. Here, we present a method, dubbed as Recursive-TCM, that is able to provide lensing predictions with an arbitrarily low discreteness noise. This solution is based on a novel way of interpreting the results of N-body simulations, where particles simply trace the evolution and distortion of Lagrangian phase-space volume elements. We discuss the advantages and limitations of this method compared to the widely used density estimators based on cloud-in-cells and adaptive-kernel smoothing. Applying the new method to a cluster-sized DM halo simulated in warm and cold DM scenarios, we show how the expected differences in their substructure population translate into differences in convergence and magnification maps. We anticipate that our method will provide the high-precision theoretical predictions required to interpret and fully exploit strong gravitational lensing observations.

  4. Gravitational Lenses in the Classroom

    ERIC Educational Resources Information Center

    Ros, Rosa M.

    2008-01-01

    It is not common to introduce current astronomy in school lessons. This article presents a set of experiments about gravitational lenses. It is normal to simulate them by means of computers, but it is very simple to simulate similar effects using a drinking glass full of liquid or using only the glass base. These are, of course, cheap and easy…

  5. The Optical Gravitational Lensing Experiment

    NASA Technical Reports Server (NTRS)

    Udalski, A.; Szymanski, M.; Kaluzny, J.; Kubiak, M.; Mateo, Mario

    1992-01-01

    The technical features are described of the Optical Gravitational Lensing Experiment, which aims to detect a statistically significant number of microlensing events toward the Galactic bulge. Clusters of galaxies observed during the 1992 season are listed and discussed and the reduction methods are described. Future plans are addressed.

  6. Gravitational Lensing of Supernova Neutrinos

    SciTech Connect

    Mena, Olga; Mocioiu, Irina; Quigg, Chris; /Fermilab

    2006-10-01

    The black hole at the center of the galaxy is a powerful lens for supernova neutrinos. In the very special circumstance of a supernova near the extended line of sight from Earth to the galactic center, lensing could dramatically enhance the neutrino flux at Earth and stretch the neutrino pulse.

  7. Corneal response to rigid and hydrogel lenses during eye closure.

    PubMed

    O'Neal, M R; Polse, K A; Sarver, M D

    1984-07-01

    Corneal changes were monitored in 14 subjects following 3 hr of eye closure while wearing selected oxygen permeable rigid and hydrogel lenses. The mean increase in corneal thickness ranged from 82.5 to 29.5 microns for rigid lenses with oxygen transmissibilities (Dk/L) between 0.2 X 10(-9) and 57.0 X 10(-9) (cm/sec) (ml O2/ml X mmHg), respectively, and ranged from 82.5 to 23.5 microns for hydrogel lenses with Dk/L between 2.5 X 10(-9) and 70.0 X 10(-9) (cm/sec) (ml O2/ml X mmHg), respectively. No differences in the amount of swelling between rigid and hydrogel lenses of the same oxygen transmissibility were observed (t-test, P greater than 0.20). Combining the swelling data for both types of lenses shows that a minimum lens oxygen transmissibility of approximately 75 X 10(-9) (cm/sec) (ml O2/ml X mmHg) is necessary during eye closure to prevent contact lens induced edema. The estimated oxygen tension under a lens with this Dk/L value is 40 mmHg. Recovery of the cornea to baseline thickness follows a nonlinear time course, with the rate of dehydration decreasing as the cornea thins. For initial swelling of 40-54 microns, 55-69 microns, and 70 microns and above, the time to reach baseline thickness was 1.5, 2.0, and 2.5 hr, respectively. Effects on vision, corneal curvature, distortion, and epithelial integrity were not clinically significant during this short period of eye closure.

  8. Biochemical analyses of lipids deposited on silicone hydrogel lenses

    PubMed Central

    Hatou, Shin; Fukui, Masaki; Yatsui, Keiichi; Mochizuki, Hiroshi; Akune, Yoko; Yamada, Masakazu

    2010-01-01

    Purpose This study was performed to determine the levels of lipids deposited on in vivo worn silicone hydrogel lenses. Methods Three silicone hydrogel materials, galyfilcon A, senofilcon A, and asmofilcon A, were worn for 2 weeks by 35 normal subjects. Total lipid deposition was determined by the sulfo-phospho-vanillin reaction. Cholesterol was estimated by a colorimetric probe through enzymatic oxidation. Phospholipid level was estimated by determining phosphorus with ammonium molybdate through enzymatic digestion. Results The total lipid content recovered from galyfilcon A, senofilcon A, and asmofilcon A was 32.9 ± 33.8, 42.1 ± 14.0, and 36.6 ± 31.9 μg/lens, respectively. The cholesterol content recovered from galyfilcon A, senofilcon A, and asmofilcon A was 26.2 ± 26.9, 28.6 ± 19.4, and 31.1 ± 21.1 μg/lens, respectively. There were no statistically significant differences in total lipids and cholesterol among the contact lens types. However, the quantity of phospholipid recovered from the asmofilcon A (7.0 ± 5.5 μg/lens) lenses was significantly higher than from galyfilcon A (1.1 ± 0.8 μg/lens) and senofilcon A (2.4 ± 0.8 mg/lens) lenses (p < 0.05, Mann-Whitney test). Conclusions The quantity of total lipid and cholesterol deposited on the 3 silicone hydrogel lenses tested did not differ. However, there were significant differences in the amounts of phospholipid deposited among the 3 silicone hydrogel lenses, of which clinical significance should be explored in the future study.

  9. Thermal lensing of laser materials

    NASA Astrophysics Data System (ADS)

    Davis, Mark J.; Hayden, Joseph S.

    2014-10-01

    This paper focuses on the three main effects that can induce wave-front distortion due to thermal lensing in laser gain media: 1) thermo-optic (dn/dT); 2) stress-optic; and 3) surface deformation (e.g., "end-bulging" of a laser rod). Considering the simple case of a side-pumped cylindrical rod which is air- or water-cooled along its length, the internal temperature distribution has long been known to assume a simple parabolic profile. Resulting from this are two induced refractive index variations due to thermo-optic and stress-optic effects that also assume a parabolic profile, but generally not of the same magnitude, nor even of the same sign. Finally, a small deformation on the rod ends can induce a small additional lensing contribution. We had two goals in this study: a) use finite-element simulations to verify the existing analytical expressions due to Koechner1 and Foster and Osterink; and b) apply them to glasses from the SCHOTT laser glass portfolio. The first goal was a reaction to more recent work by Chenais et al. who claimed Koechner made an error in his analysis with regard to thermal stress, throwing into doubt conclusions within studies since 1970 which made use of his equations. However, our re-analysis of their derivations, coupled with our FE modeling, confirmed that the Koechner and Foster and Osterink treatments are correct, and that Chenais et al. made mistakes in their derivation of the thermally-induced strain. Finally, for a nominal laser rod geometry, we compared the thermally-induced optical distortions in LG-680, LG-750, LG-760, LG-770, APG-1, and APG-2. While LG-750, -760, and -770 undergo considerable thermo-optic lensing, their stress-optic lensing is nearly of the same magnitude but of opposite sign, leading to a small total thermal lensing signature.

  10. Effects of aqueous polymeric surfactants on silicone-hydrogel soft- contact-lens wettability and bacterial adhesion of Pseudomonas aeruginosa.

    PubMed

    Tran, Victoria B; Sung, Ye Suel; Copley, Kendra; Radke, C J

    2012-08-01

    Prevention of Pseudomonas aeruginosa binding to soft-contact lenses (SCLs) may curtail sight-threatening microbial keratitis. Substrate surface wettability is known to modulate adhesion of P. aeruginosa. This study investigates the use of aqueous alkoxylate block co-polymer surfactants for enhanced wettability and antibacterial adhesion of SCLs under leaching conditions. Specifically, Pluronic(®) F127 (PF) and three ethylene oxide-butylene oxide (EOBO) surfactants were studied with four commercially available silicone-hydrogel contact lenses: Pure Vision™, Acuvue Advance™, Acuvue Oasys™ and O(2)Optix™. Dilute aqueous PF and EOBO surfactants impregnated all four soft-contact lenses, as demonstrated by surface-tension decline for leached surfactant. For PF surfactant, significant surface-wettability improvement upon rinsing occurred only after overnight leaching. EOBO surfactant showed a similar pattern with O(2)Optix™ lenses. EOBO-pretreated Pure Vision™ lenses, however, showed fast leaching and a significant change in surface energy towards improved wettability. Adhesion assays of P. aeruginosa displayed a small decrease in the binding rate of PAK bacteria for EOBO-pretreated Pure Vision™ lenses, but not for EOBO-pretreated O(2)Optix™ lenses. P. aeruginosa strain-PAO1 bacteria adhesion to all lenses was independent of surface wettability. Despite the ability of polymeric surfactants to lower advancing contact angles under leaching conditions, increased lens wettability is not a universal panacea for antifouling of soft-contact lenses.

  11. EDITORIAL: Focus on Gravitational Lensing

    NASA Astrophysics Data System (ADS)

    Jain, Bhuvnesh

    2007-11-01

    Gravitational lensing emerged as an observational field following the 1979 discovery of a doubly imaged quasar lensed by a foreground galaxy. In the 1980s and '90s dozens of other multiply imaged systems were observed, as well as time delay measurements, weak and strong lensing by galaxies and galaxy clusters, and the discovery of microlensing in our galaxy. The rapid pace of advances has continued into the new century. Lensing is currently one of best techniques for finding and mapping dark matter over a wide range of scales, and also addresses broader cosmological questions such as understanding the nature of dark energy. This focus issue of New Journal of Physics presents a snapshot of current research in some of the exciting areas of lensing. It provides an occasion to look back at the advances of the last decade and ahead to the potential of the coming years. Just about a decade ago, microlensing was discovered through the magnification of stars in our galaxy by invisible objects with masses between that of Jupiter and a tenth the mass of the Sun. Thus a new component of the mass of our galaxy, dubbed MACHOs, was established (though a diffuse, cold dark matter-like component is still needed to make up most of the galaxy mass). More recently, microlensing led to another exciting discovery—of extra-solar planets with masses ranging from about five times that of Earth to that of Neptune. We can expect many more planets to be discovered through ongoing surveys. Microlensing is the best technique for finding Earth mass planets, though it is not as productive overall as other methods and does not allow for follow up observations. Beyond planet hunting, microlensing has enabled us to observe previously inaccessible systems, ranging from the surfaces of other stars to the accretion disks around the black holes powering distant quasars. Galaxies and galaxy clusters at cosmological distances can produce dramatic lensing effects: multiple images of background galaxies

  12. Visual Performance of Contact Lens-Corrected Ametropic Aviators with the M-43 Protective Mask

    DTIC Science & Technology

    1990-05-01

    lenses and wearing regime: CL subjects were fitted with Vistakon * Acuvue N disposable soft (hydrogel) contact lenses having a nominal water content of...University Drive Tempe, AZ 85281 Paravant Computer Systems 7800 Technology Drive Melbourne, FL 32904 Vistakon , Incorporated P. 0. Box 10157

  13. Comparation of effectiveness of silicone hydrogel contact lens and hydrogel contact lens in patients after LASEK

    PubMed Central

    Xie, Wen-Juan; Zeng, Jin; Cui, Ying; Li, Juan; Li, Zhong-Ming; Liao, Wei-Xiong; Yang, Xiao-Hong

    2015-01-01

    AIM To conduct a comparative study of effectiveness of silicone hydrogel contact lens and hydrogel contact lens, which are used in patients after laser-assisted subepithelial keratomileusis (LASEK). METHODS Sixty-three patients (121 eyes) with a spherical equivalent ≤-5.0 D were chosen after undergoing LASEK in 2012 at Guangdong General Hospital. They were randomly divided into 2 groups. The silicone hydrogel group included 32 cases (61 eyes) that wore silicone hydrogel contact lenses for 4-6d after the operation, while the hydrogel group included 31 cases (60 eyes) who wore hydrogel contact lenses for 4-6d after the operation. Patients' self-reported postoperative symptoms (including pain, photophobia, tears, and foreign body sensation) were evaluated. The healing time of the corneal epithelium, the visual acuity of patients without contact lens after epithelial healing, and the incidence of delayed corneal epithelial shedding were also assessed. The follow-up time was 1mo. RESULTS Postoperative symptoms were milder in the silicone hydrogel group than in the hydrogel group. There were significant differences in pain, foreign body sensation, and photophobia between the 2 groups (P<0.05), although there was no significant difference in postoperative tearing (P>0.05). The healing time of the corneal epithelium in the silicone hydrogel lens group was markedly shorter than that in the hydrogel group (4.07±0.25 vs 4.33±0.82d, t=2.43, P=0.02). Visual acuity without contact lenses after healing of the corneal epithelium was better in the silicone hydrogel group compared with the hydrogel group (χ2=7.76, P=0.02). There was no significant difference in the occurrence of delayed corneal epithelial shedding between the 2 groups (P>0.05). CONCLUSION Patients with LASEK using silicon hydrogel contact lenses had less discomfort and shorter corneal epithelial healing time compared with those using hydrogel contact lenses, suggesting that silicon hydrogel contact lenses may

  14. Contact Dermatitis

    MedlinePlus

    ... Us Media contacts Advertising contacts AAD logo Advertising, marketing and sponsorships Legal notice Copyright © 2017 American Academy ... prohibited without prior written permission. AAD logo Advertising, marketing and sponsorships Legal notice Copyright © 2017 American Academy ...

  15. Ophthalmic Glucose Monitoring Using Disposable Contact Lenses—A Review

    PubMed Central

    Badugu, Ramachandram; Lakowicz, Joseph R.; Geddes, Chris D.

    2016-01-01

    We have developed a range of disposable and colorless tear glucose sensing contact lenses, using off-the-shelf lenses embedded with new water soluble, highly fluorescent and glucose sensitive boronic acid containing fluorophores. The new lenses are readily able to track tear glucose levels and therefore blood glucose levels, which are ideally suited for potential use by diabetics. The fluorescence responses from the lenses can be monitored using simple excitation and emission detection devices. The novelty of our approach is two fold. Firstly, the notion of sensing extremely low glucose concentrations in tears, which track blood levels, by our contact lens approach, and secondly, the unique compatibility of our new glucose signaling probes with the internal mildly acidic contact lens environment. The new lenses are therefore ideal for the non-invasive and continuous monitoring of tear glucose, with about 15-min response time, and a measured shelf life in excess of 3 months. In this review article, we show that fluorescence based signaling using plastic disposable lenses, which have already been industrially optimized with regard to vision correction and oxygen/analyte permeability etc, may a notable alternative to invasive and random finger pricking, the most widely used glucose monitoring technology by diabetics. PMID:15617269

  16. Fabrication of high-efficiency Fresnel-type lenses by pinhole diffraction imaging of sol-gel hybrid materials

    SciTech Connect

    Kang, Dong Jun; Phong, Phan Viet; Bae, Byeong-Soo

    2004-11-08

    Sol-gel hybrid materials containing a large quantity of photoactive molecules exhibited large changes in both refractive index and volume on UV exposure. The materials were used for fabrication of Fresnel-type lenses using a simple method: pinhole diffraction imaging. With this technique, problems associated with the contact method could be overcome and Fresnel-type lenses with good focusing performance could be fabricated easily. Importantly, a high diffraction efficiency approaching 85% could be obtained.

  17. The shape of the CMB lensing bispectrum

    SciTech Connect

    Lewis, Antony; Challinor, Anthony; Hanson, Duncan E-mail: adc1000@ast.cam.ac.uk

    2011-03-01

    Lensing of the CMB generates a significant bispectrum, which should be detected by the Planck satellite at the 5-sigma level and is potentially a non-negligible source of bias for f{sub NL} estimators of local non-Gaussianity. We extend current understanding of the lensing bispectrum in several directions: (1) we perform a non-perturbative calculation of the lensing bispectrum which is ∼ 10% more accurate than previous, first-order calculations; (2) we demonstrate how to incorporate the signal variance of the lensing bispectrum into estimates of its amplitude, providing a good analytical explanation for previous Monte-Carlo results; and (3) we discover the existence of a significant lensing bispectrum in polarization, due to a previously-unnoticed correlation between the lensing potential and E-polarization as large as 30% at low multipoles. We use this improved understanding of the lensing bispectra to re-evaluate Fisher-matrix predictions, both for Planck and cosmic variance limited data. We confirm that the non-negligible lensing-induced bias for estimation of local non-Gaussianity should be robustly treatable, and will only inflate f{sub NL} error bars by a few percent over predictions where lensing effects are completely ignored (but note that lensing must still be accounted for to obtain unbiased constraints). We also show that the detection significance for the lensing bispectrum itself is ultimately limited to 9 sigma by cosmic variance. The tools that we develop for non-perturbative calculation of the lensing bispectrum are directly relevant to other calculations, and we give an explicit construction of a simple non-perturbative quadratic estimator for the lensing potential and relate its cross-correlation power spectrum to the bispectrum. Our numerical codes are publicly available as part of CAMB and LensPix.

  18. Tomography and weak lensing statistics

    SciTech Connect

    Munshi, Dipak; Coles, Peter; Kilbinger, Martin E-mail: peter.coles@astro.cf.ac.uk

    2014-04-01

    We provide generic predictions for the lower order cumulants of weak lensing maps, and their correlators for tomographic bins as well as in three dimensions (3D). Using small-angle approximation, we derive the corresponding one- and two-point probability distribution function for the tomographic maps from different bins and for 3D convergence maps. The modelling of weak lensing statistics is obtained by adopting a detailed prescription for the underlying density contrast that involves hierarchal ansatz and lognormal distribution. We study the dependence of our results on cosmological parameters and source distributions corresponding to the realistic surveys such as LSST and DES. We briefly outline how photometric redshift information can be incorporated in our results. We also show how topological properties of convergence maps can be quantified using our results.

  19. Seeing Patients Through Genetic Lenses

    PubMed Central

    FELCONE, LINDA HULL

    2005-01-01

    Biotechnology is changing how doctors ‘see’ patients and disease processes. Optical probes and computer-assisted genetic screening tools let researchers peer into the structure and functions of cellular proteins on a molecular level. Soon, this clearer vision of individual patients will be available in the clinic, making drug and biologic treatments safer. These new lenses will push medicine toward risk prediction and away from acute intervention. PMID:23393472

  20. Biomimetic Gradient Index (GRIN) Lenses

    DTIC Science & Technology

    2006-01-01

    optics include single lenses inspired by cephalopod (octopus) eyes and a three-lens, wide field of view, optical system for a surveillance sensor...camera. Details are easily resolv- able with the polymer lens. This lens system was installed on an Evolution unmanned aerial vehicle (UAV) with a...lens system was installed in an NRL Evolution UAV and used to record video images at a height of up to 1000 ft. The index gradients in the polymer

  1. Telocyte's contacts.

    PubMed

    Faussone-Pellegrini, Maria-Simonetta; Gherghiceanu, Mihaela

    2016-07-01

    Telocytes (TC) are an interstitial cell type located in the connective tissue of many organs of humans and laboratory mammals. By means of homocellular contacts, TC build a scaffold whose meshes integrity and continuity are guaranteed by those contacts having a mechanical function; those contacts acting as sites of intercellular communication allow exchanging information and spreading signals. Heterocellular contacts between TC and a great variety of cell types give origin to mixed networks. TC, by means of all these types of contacts, their interaction with the extracellular matrix and their vicinity to nerve endings, are part of an integrated system playing tissue/organ-specific roles.

  2. RELICS: Reionization Lensing Cluster Survey

    NASA Astrophysics Data System (ADS)

    Coe, Dan A.; RELICS Team

    2017-01-01

    Hubble and Spitzer imaging programs observing galaxy cluster lenses have delivered some of the highest redshift galaxy candidates to date (z ~ 9 - 11, or 540 - 410 Myr after the Big Bang). These magnified galaxies are intrinsically faint, and thus more representative of the sources believed to be primarily responsible for reionization. Magnified galaxies are also observed brightly enough to be prime targets for detailed follow-up study with current and future observatories, including JWST. Building on the successes of CLASH and the Frontier Fields, we have begun RELICS, the Reionization Lensing Cluster Survey. By observing 41 massive clusters for the first time at infrared wavelengths, RELICS will deliver more of the best and brightest high-redshift candidates to the community in time for the November 2017 JWST GO Cycle 1 call for proposals. I will present our early results. I will also discuss prospects for JWST to follow-up known candidates and discover new galaxies at even higher redshifts (z > 11). The discovery efficiency gains from lensing will be even more pronounced at z > 11 if luminosity function faint end slopes are steeper than alpha ~ -2, as suggested by current models and observational extrapolations.

  3. Gravitational lensing in plasmic medium

    SciTech Connect

    Bisnovatyi-Kogan, G. S. Tsupko, O. Yu.

    2015-07-15

    The influence of plasma on different effects of gravitational lensing is reviewed. Using the Hamiltonian approach for geometrical optics in a medium in the presence of gravity, an exact formula for the photon deflection angle by a black hole (or another body with a Schwarzschild metric) embedded in plasma with a spherically symmetric density distribution is derived. The deflection angle in this case is determined by the mutual combination of different factors: gravity, dispersion, and refraction. While the effects of deflection by the gravity in vacuum and the refractive deflection in a nonhomogeneous medium are well known, the new effect is that, in the case of a homogeneous plasma, in the absence of refractive deflection, the gravitational deflection differs from the vacuum deflection and depends on the photon frequency. In the presence of a plasma nonhomogeneity, the chromatic refractive deflection also occurs, so the presence of plasma always makes gravitational lensing chromatic. In particular, the presence of plasma leads to different angular positions of the same image if it is observed at different wavelengths. It is discussed in detail how to apply the presented formulas for the calculation of the deflection angle in different situations. Gravitational lensing in plasma beyond the weak deflection approximation is also considered.

  4. Gravitational lensing in plasmic medium

    NASA Astrophysics Data System (ADS)

    Bisnovatyi-Kogan, G. S.; Tsupko, O. Yu.

    2015-07-01

    The influence of plasma on different effects of gravitational lensing is reviewed. Using the Hamiltonian approach for geometrical optics in a medium in the presence of gravity, an exact formula for the photon deflection angle by a black hole (or another body with a Schwarzschild metric) embedded in plasma with a spherically symmetric density distribution is derived. The deflection angle in this case is determined by the mutual combination of different factors: gravity, dispersion, and refraction. While the effects of deflection by the gravity in vacuum and the refractive deflection in a nonhomogeneous medium are well known, the new effect is that, in the case of a homogeneous plasma, in the absence of refractive deflection, the gravitational deflection differs from the vacuum deflection and depends on the photon frequency. In the presence of a plasma nonhomogeneity, the chromatic refractive deflection also occurs, so the presence of plasma always makes gravitational lensing chromatic. In particular, the presence of plasma leads to different angular positions of the same image if it is observed at different wavelengths. It is discussed in detail how to apply the presented formulas for the calculation of the deflection angle in different situations. Gravitational lensing in plasma beyond the weak deflection approximation is also considered.

  5. 30 CFR 18.30 - Windows and lenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Windows and lenses. 18.30 Section 18.30 Mineral... § 18.30 Windows and lenses. (a) MSHA may waive testing of materials for windows or lenses except headlight lenses. When tested, material for windows or lenses shall meet the test requirements prescribed...

  6. 30 CFR 18.30 - Windows and lenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Windows and lenses. 18.30 Section 18.30 Mineral... § 18.30 Windows and lenses. (a) MSHA may waive testing of materials for windows or lenses except headlight lenses. When tested, material for windows or lenses shall meet the test requirements prescribed...

  7. 30 CFR 18.30 - Windows and lenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Windows and lenses. 18.30 Section 18.30 Mineral... § 18.30 Windows and lenses. (a) MSHA may waive testing of materials for windows or lenses except headlight lenses. When tested, material for windows or lenses shall meet the test requirements prescribed...

  8. Gravitational lenses and dark matter - Theory

    NASA Technical Reports Server (NTRS)

    Gott, J. Richard, III

    1987-01-01

    Theoretical models are presented for guiding the application of gravitational lenses to probe the characteristics of dark matter in the universe. Analytical techniques are defined for quantifying the mass associated with lensing galaxies (in terms of the image separation), determining the quantity of dark mass of the lensing bodies, and estimating the mass density of the lenses. The possibility that heavy halos are made of low mass stars is considered, along with the swallowing of central images of black holes or cusps in galactic nuclei and the effects produced on a lensed quasar image by nonbaryonic halos. The observable effects of dense groups and clusters and the characteristics of dark matter strings are discussed, and various types of images which are possible due to lensing phenomena and position are described.

  9. Inflatable lenses for space photovoltaic concentrator arrays

    SciTech Connect

    O`Neill, M.J.; Piszczor, M.F.

    1997-12-31

    For 12 years, ENTECH and NASA Lewis have been developing Fresnel lens concentrator technology for space power applications. ENTECH provided the point-focus mini-dome lenses for the PASP+ array, launched in 1994. These silicone lenses performed well on orbit, with only about 3% optical performance loss after 1 year in elliptical orbit, with high radiation, atomic oxygen, and ultraviolet exposure. The only protection for these silicone lenses was a thin-film coating provided by OCLI. ENTECH also provided the line-focus lenses for the SCARLET 1 and SCARLET 2 arrays in 1995 and 1997, respectively. These lenses are laminated assemblies, with protective ceria glass superstrates over the silicone lens. In March 1997, ENTECH and NASA Lewis began development of inflatable Fresnel lenses, to achieve lower weight, smaller launch volume, reduced cost, less fragility, and other advantages. This paper summarizes the new concentrator approach, including key program results to date.

  10. Aberrations of sphero-cylindrical ophthalmic lenses.

    PubMed

    Malacara, Z; Malacara, D

    1990-04-01

    The authors have presented in two previous articles the graphic solutions resembling Tscherning ellipses, for spherical as well as for aspherical ophthalmic lenses free of astigmatism or power error. These solutions were exact, inasmuch as they were based on exact ray tracing, and not third-order theory as frequently done. In this paper sphero-cylindrical lenses are now analyzed, also using exact ray tracing. The functional dependence of the astigmatism and the power error for these lenses is described extensively.

  11. Effects of temperature and conditioning on contact lens wetting angles.

    PubMed

    Knick, P D; Huff, J W

    1991-07-01

    Because wettability is not always examined under standard conditions, we investigated the temperature dependence of saline wettability on unconditioned and conditioned polymethylmethacrylate (PMMA), cellulose acetate butyrate (CAB), and three silicone acrylate lens materials. Sessile drop contact angles were measured in a humidity chamber at 23 degrees C and 34 degrees C using laser-assisted contact angle goniometry. In separate experiments, saline-stored and preconditioned lenses were examined either with or without rinsing. Sessile drop contact angles at 34 degrees C were within 2 degrees to 5 degrees of the room temperature values for both conditioned and unconditioned lenses, demonstrating a negligible temperature dependence. At both temperatures, the conditioned PMMA, CAB, silafocon A, and pasifocon C lenses wet slightly better, by 1 degree to 12 degrees, than unconditioned lenses. However, this increase was only significant with PMMA and silafocon A (P less than 0.05) and reversed when the preconditioned lenses were rinsed repeatedly in saline and reexamined. The results suggest that for these materials: 1) in vitro saline contact angles do not approach those seen on the eye, and this discrepancy can not be explained by temperature or conditioning; and 2) conditioning does not increase material wettability but merely forms a temporary hydrophilic interface that is more wettable than the lens material.

  12. The Alvarez and Lohmann refractive lenses revisited.

    PubMed

    Barbero, Sergio

    2009-05-25

    Alvarez and Lohmann lenses are variable focus optical devices based on lateral shifts of two lenses with cubic-type surfaces. I analyzed the optical performance of these types of lenses computing the first order optical properties (applying wavefront refraction and propagation) without the restriction of the thin lens approximation, and the spot diagram using a ray tracing algorithm. I proposed an analytic and numerical method to select the most optimum coefficients and the specific configuration of these lenses. The results show that Lohmann composite lens is slightly superior to Alvarez one because the overall thickness and optical aberrations are smaller.

  13. Ion exchange tempering of glass ophthalmic lenses.

    PubMed

    Keeney, A H; Duerson, H L

    1975-08-01

    We performed low velocity drop-ball tests using 5/8-, 7/8-, and 1-inch diameter steel balls on ophthalmic crown glass lenses chemically tempered by the ion exchange process. Four representative dioptric strengths (+ 2.50 spherical, - 2.50 spherical, -2.50 cylindrical, and plano) were studied with the isolated lenses mounted, convex side up, on the American National Standards Institute Z80 test block. New ion exchange lenses exhibited a 100 to 350% greater capacity for attenuation of energy from low velocity, large size missiles than matched lenses of similar strength prepared by the conventional heat-treating and air-quenching process.

  14. Soft toric contact lens prescribing in different countries.

    PubMed

    Efron, Nathan; Morgan, Philip B; Helland, Magne; Itoi, Motozumi; Jones, Deborah; Nichols, Jason J; van der Worp, Eef; Woods, Craig A

    2011-02-01

    There have been significant improvements in toric soft contact lens design over the past decade. Data from our international contact lens prescribing survey were mined to assess recent trends in toric soft contact lens fitting. This survey was conducted by sending up to 1000 survey forms to contact lens fitters in Australia, Canada, Japan, the Netherlands, Norway, the UK and the USA each year between 2000 and 2009. Practitioners were asked to record data relating to the first 10 contact lens fits or refits performed after receiving the forms and to return them to us for analysis. The data revealed a gradual increase in the extent of toric soft lens fitting this century. Excluding Japan--which had a consistently low rate of soft toric lens fitting over the survey period--soft toric lenses now represent over 35% of all soft lenses prescribed; it can be assumed that, on average (and again excluding Japan), all cases of astigmatism 0.75 D or less remains uncorrected among contact lens wearers. Toric lenses are fitted more to those who are older, full-time wearers and reusable lens wearers, and less to those wearing silicone hydrogel and extended wear lenses.

  15. [Acanthamoeba sp.: a case report in a non-contact lens wearer].

    PubMed

    Menghi, Claudia; Caride, María C; Gatta, Claudia

    2012-01-01

    Acanthamoeba sp. keratitis is generally related to wearing contact lenses, and, to a lesser extent, to contaminated water. It is characterized by reduced visual capacity and the presence of severe ocular pain. Clinically, it can be mistaken for a herpes infection. if it is not diagnosed, and timely and adequately treated, it can result in corneal perforation and, eventually, in vision loss. One of the few registered cases of Acanthamoeba sp. keratitis not related to the use of contact lenses is herein reported.

  16. Wetting angles of rigid contact lens plastics: the effect of contact lens wear.

    PubMed

    Poster, M G; Gelfer, D M; Fernandez, N M

    1986-06-01

    Several adapted rigid contact lens wearers were given duplicates of their present lenses made in different plastics. They were required to wear each material on each eye for a period of four hours. Both the average wetting angle and its range of values for each material was compiled. All lenses tended to give similar average wetting angles but ranges of angles for the PMMA/siloxanyl materials were greater than that for PMMA and GP IITM. Both values should be utilized when evaluating the wettability of a specific material.

  17. Increased resistance of contact lens related bacterial biofilms to antimicrobial activity of soft contact lens care solutions

    PubMed Central

    Szczotka-Flynn, Loretta B.; Imamura, Yoshifumi; Chandra, Jyotsna; Yu, Changping; Mukherjee, Pranab K.; Pearlman, Eric; Ghannoum, Mahmoud A.

    2014-01-01

    PURPOSE To determine if clinical and reference strains of Pseudomonas aeruginosa, Serratia marcescens, and Staphylococcus aureus form biofilms on silicone hydrogel contact lenses, and ascertain antimicrobial activities of contact lens care solutions. METHODS Clinical and American Type Culture Collection (ATCC) reference strains of Pseudomonas aeruginosa, Serratia marcescens, and Staphylococcus aureus were incubated with lotrafilcon A lenses under conditions that facilitate biofilm formation. Biofilms were quantified by quantitative culturing (colony forming units, CFUs), and gross morphology and architecture were evaluated using scanning electron microscopy (SEM) and confocal microscopy. Susceptibilities of the planktonic and biofilm growth phases of the bacteria to five common multipurpose contact lens care solutions and one hydrogen peroxide care solution were assessed. RESULTS P. aeruginosa, S. marcescens, and S. aureus reference and clinical strains formed biofilms on lotrafilcon A silicone hydrogel contact lenses, as dense networks of cells arranged in multiple layers with visible extracellular matrix. The biofilms were resistant to commonly used biguanide preserved multipurpose care solutions. P. aeruginosa and S. aureus biofilms were susceptible to a hydrogen peroxide and a polyquaternium preserved care solution, whereas S. marcescens biofilm was resistant to a polyquaternium preserved care solution but susceptible to hydrogen peroxide disinfection. In contrast, the planktonic forms were always susceptible. CONCLUSIONS P. aeruginosa, S. marcescens, and S. aureus form biofilms on lotrafilcon A contact lenses, which in contrast to planktonic cells, are resistant to the antimicrobial activity of several soft contact lens care products. PMID:19654521

  18. Gravitational Lensing Extends SETI Range

    NASA Astrophysics Data System (ADS)

    Factor, Richard

    Microwave SETI (The Search for Extraterrestrial Intelligence) focuses on two primary strategies, the "Targeted Search" and the "All-Sky Survey." Although the goal of both strategies is the unequivocal discovery of a signal transmitted by intelligent species outside our solar system, they pursue the strategies in very different manners and have vastly different requirements. This chapter introduces Gravitational Lensing SETI (GL-SETI), a third strategy. Its goal is the unequivocal discovery of an extraterrestrial signal, with equipment and data processing requirements that are substantially different from the commonly-used strategies. This strategy is particularly suitable for use with smaller radio telescopes and has budgetary requirements suitable for individual researchers.

  19. Pseudomonas aeruginosa Survival at Posterior Contact Lens Surfaces after Daily Wear

    PubMed Central

    Wu, Yvonne T.; Zhu, Lucia S.; Tam, K. P. Connie; Evans, David J.; Fleiszig, Suzanne M. J.

    2015-01-01

    Purpose Pseudomonas aeruginosa keratitis is a sight-threatening complication of contact lens wear, yet mechanisms by which lenses predispose to infection remain unclear. Here, we tested the hypothesis that tear fluid at the posterior contact lens surface can lose antimicrobial activity over time during lens wear. Methods Daily disposable lenses were worn for 1, 2, 4, 6 or 8 h immediately after removal from their packaging, or after presoaking in sterile saline for 2 days to remove packaging solution. Unworn lenses were also tested, some coated in tears “aged” in vitro for 1 or 8 h. Lenses were placed anterior surface down into tryptic soy agar cradles containing gentamicin (100µg/ml) to kill bacteria already on the lens, and posterior surfaces inoculated with gentamicin-resistant P. aeruginosa for 3 h. Surviving bacteria were enumerated by viable counts of lens homogenates. Results Posterior surfaces of lenses worn by patients for 8 h supported more P. aeruginosa growth than lenses worn for only 1 h, if lenses were presoaked prior to wear (~ 2.4-fold, p = 0.01). This increase was offset if lenses were not presoaked to remove packaging solution (p = 0.04 at 2 h and 4 h). Irrespective of presoaking, lenses worn for 8 h showed more growth on their posterior surface than unworn lenses coated with tear fluid that was “aged” for 8 h vitro (~8.6-fold, presoaked, p = 0.003: ~ 5.4-fold from packaging solution, p = 0.004). Indeed, in vitro incubation did not impact tear antimicrobial activity. Conclusions This study shows that post lens tear fluid can lose antimicrobial activity over time during contact lens wear, supporting the idea that efficient tear exchange under a lens is critical for homeostasis. Additional studies are needed to determine applicability to other lens types, wearing modalities, and relevance to contact lens-related infections. PMID:25955639

  20. Contact lens disinfection by ultraviolet light

    SciTech Connect

    Dolman, P.J.; Dobrogowski, M.J. )

    1989-12-15

    A 253.7-nm ultraviolet light with an intensity of 1,100 microW/cm2 was tested for its germicidal activity against contact lenses and storage solutions contaminated with various corneal pathogens. The exposure time necessary to reduce a concentration of organisms from 10(6)/ml to less than 10/ml was 30 seconds for Staphylococcus aureus, 60 seconds for Pseudomonas aeruginosa, and 84 seconds for Candida albicans. The time necessary to sterilize a suspension of 10(4)/ml Acanthamoeba polyphaga was less than three minutes with this technique. Four brands of soft contact lenses were exposed to ultraviolet light for over eight hours without changing their appearance, comfort, or refraction.

  1. Offset lenses add versatility to phototypesetting machine

    NASA Technical Reports Server (NTRS)

    James, A. M.

    1966-01-01

    Offset lenses facilitate the composition of inputs of other than straight baseline characters on the Photon phototypesetting machine. A number of lenses in the turret are mounted in an offset pattern that causes characters projected through them to fall on the photographic paper in the magazine above and below the baseline.

  2. BAYESIAN INFERENCE OF CMB GRAVITATIONAL LENSING

    SciTech Connect

    Anderes, Ethan; Wandelt, Benjamin D.; Lavaux, Guilhem

    2015-08-01

    The Planck satellite, along with several ground-based telescopes, has mapped the cosmic microwave background (CMB) at sufficient resolution and signal-to-noise so as to allow a detection of the subtle distortions due to the gravitational influence of the intervening matter distribution. A natural modeling approach is to write a Bayesian hierarchical model for the lensed CMB in terms of the unlensed CMB and the lensing potential. So far there has been no feasible algorithm for inferring the posterior distribution of the lensing potential from the lensed CMB map. We propose a solution that allows efficient Markov Chain Monte Carlo sampling from the joint posterior of the lensing potential and the unlensed CMB map using the Hamiltonian Monte Carlo technique. The main conceptual step in the solution is a re-parameterization of CMB lensing in terms of the lensed CMB and the “inverse lensing” potential. We demonstrate a fast implementation on simulated data, including noise and a sky cut, that uses a further acceleration based on a very mild approximation of the inverse lensing potential. We find that the resulting Markov Chain has short correlation lengths and excellent convergence properties, making it promising for applications to high-resolution CMB data sets in the future.

  3. Lenses and Perception: Investigations with Light

    ERIC Educational Resources Information Center

    Akcay, Hakan

    2005-01-01

    The main goals of these activities are to help students learn how a convex lens can serve as a magnifying lens and how light travels and creates images. These explorations will introduce middle school students to different types of lenses and how they work. Students will observe and describe how lenses bend light that passes through them and how…

  4. Phakic Intraocular Lenses and their Special Indications

    PubMed Central

    Pineda, Roberto; Chauhan, Tulika

    2016-01-01

    Phakic intraocular lenses revolutionize refractive surgery and continue to serve as an excellent option for vision correction in patients who are not ideal candidates for laser vision correction. This article will review special indications of phakic intraocular lenses in the clinical practice. PMID:27994811

  5. Weak gravitational lensing theory and data analysis

    NASA Astrophysics Data System (ADS)

    Hirata, Christopher Michael

    2005-12-01

    This thesis describes methodology for analysis of weak gravitational lensing data. Weak lensing, i.e. the perturbative distortion of the images of distant objects by the gravitational deflection of light, is an important tool for understanding the distribution of matter in the universe. This is interesting because a number of extentions to the standard cosmological model, including dynamical dark energy and neutrino masses, affect the growth of structure and hence may be detectable using weak lensing. Studies of weak lensing are also motivated by lensing's ability to affect the modes in the cosmic microwave background (CMB) polarization that are sensitive to primordial gravitational waves. Both lensing of galaxies and lensing of the CMB are considered here. The section devoted to galaxies is principally concerned with measuring the lensing-induced shape distortions from galaxy images in the Sloan Digital Sky Survey (SDSS), although the methodology will be applicable to future projects. We investigate in detail the problem of separating lensing from other shape distortions such as those induced by the atmosphere, the telescope, and photon Poisson noise. Since the intrinsic shapes of observed galaxies are not known, weak lensing observations always attempt some sort of statistical averaging over galaxies that presumably have independent orientations. We investigate the extent to which this process "averages down" the intrinsic shapes and identify a new type of bias that can affect the weak lensing power spectrum. Selection biases are considered and their importance in SDSS estimated. We present some recent cosmological results using the SDSS analysis, including new upper limits on the neutrino mass. Lensing of the CMB has not yet been detected, nevertheless several experiments are being built that should have the sensitivity to see it. The statistical problem of extracting lensing information from the distortion of the CMB anisotropy is considered, and in the case of

  6. The Search for Lensed Supernovae

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2017-01-01

    Type Ia supernovae that have multiple images due to gravitational lensing can provide us with a wealth of information both about the supernovae themselves and about our surrounding universe. But how can we find these rare explosions?Clues from Multiple ImagesWhen light from a distant object passes by a massive foreground galaxy, the galaxys strong gravitational pull can bend the light, distorting our view of the backgroundobject. In severe cases, this process can cause multiple images of the distant object to appear in the foreground lensing galaxy.An illustration of gravitational lensing. Light from the distant supernova is bent as it passes through a giant elliptical galaxy in the foreground, causing multiple images of the supernova to appear to be hosted by the elliptical galaxy. [Adapted from image by NASA/ESA/A. Feild (STScI)]Observations of multiply-imaged Type Ia supernovae (explosions that occur when white dwarfs in binary systems exceed their maximum allowed mass) could answer a number of astronomical questions. Because Type Ia supernovae are standard candles, distant, lensed Type Ia supernovae can be used to extend the Hubble diagram to high redshifts. Furthermore, the lensing time delays from the multiply-imaged explosion can provide high-precision constraints on cosmological parameters.The catch? So far, weve only found one multiply-imaged Type Ia supernova: iPTF16geu, discovered late last year. Were going to need a lot more of them to develop a useful sample! So how do we identify themutiply-imaged Type Ias among the many billions of fleeting events discovered in current and future surveys of transients?Searching for AnomaliesAbsolute magnitudes for Type Ia supernovae in elliptical galaxies. None are expected to be above -20 in the B band, so if we calculate a magnitude for a Type Ia supernova thats larger than this, its probably not hosted by the galaxy we think it is! [Goldstein Nugent 2017]Two scientists from University of California, Berkeley and

  7. Planck 2015 results. XV. Gravitational lensing

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    We present the most significant measurement of the cosmic microwave background (CMB) lensing potential to date (at a level of 40σ), using temperature and polarization data from the Planck 2015 full-mission release. Using a polarization-only estimator, we detect lensing at a significance of 5σ. We cross-check the accuracy of our measurement using the wide frequency coverage and complementarity of the temperature and polarization measurements. Public products based on this measurement include an estimate of the lensing potential over approximately 70% of the sky, an estimate of the lensing potential power spectrum in bandpowers for the multipole range 40 ≤ L ≤ 400, and an associated likelihood for cosmological parameter constraints. We find good agreement between our measurement of the lensing potential power spectrum and that found in the ΛCDM model that best fits the Planck temperature and polarization power spectra. Using the lensing likelihood alone we obtain a percent-level measurement of the parameter combination σ8Ω0.25m = 0.591 ± 0.021. We combine our determination of the lensing potential with the E-mode polarization, also measured by Planck, to generate an estimate of the lensing B-mode. We show that this lensing B-mode estimate is correlated with the B-modes observed directly by Planck at the expected level and with a statistical significance of 10σ, confirming Planck's sensitivity to this known sky signal. We also correlate our lensing potential estimate with the large-scale temperature anisotropies, detecting a cross-correlation at the 3σ level, as expected because of dark energy in the concordance ΛCDM model.

  8. Peripheral Refraction with and without Contact Lens Correction

    PubMed Central

    Shen, Jie; Clark, Christopher A.; Soni, P. Sarita; Thibos, Larry N.

    2011-01-01

    Purpose Peripheral refractive error degrades the quality of retinal images and has been hypothesized to be a stimulus for the development of refractive error. The purpose of this study was to investigate the changes in refractive error across the horizontal visual field produced by contact lenses (CLs) and to quantify the effect of CLs on peripheral image blur. Methods A commercial Shack-Hartmann aberrometer measured ocular wavefront aberrations in 5° steps across the central 60° of visual field along the horizontal meridian before and after CLs correction. Wavefront refractions for peripheral lines-of-sight were based on the full elliptical pupil encountered in peripheral measurements. Curvature of field is the change in peripheral spherical equivalent relative to the eye’s optical axis. Results Hyperopic curvature of field in the naked eye increases with increasing amounts central myopic refractive error as predicted by Atchison (2006). For an eccentricity of E degrees, field curvature is approximately E percent of foveal refractive error. Rigid gas permeable (RGP) lenses changed field curvature in the myopic direction twice as much as soft contact lenses (SCLs). Both of these effects varied with CLs power. For all lens powers, SCL cut the degree of hyperopic field curvature in half whereas RGP lenses nearly eliminated field curvature. The benefit of reduced field curvature was partially offset by increased oblique astigmatism. The net reduction of retinal blur due to CLs is approximately constant across the visual field. Conclusions Both SCL and RGP lenses reduced the degree of hyperopic field curvature present in myopic eyes, with RGP lenses having greater effect. The tradeoff between field curvature and off-axis astigmatism with RGP lenses may limit their effectiveness for control of myopia progression. These results suggest that axial growth mechanisms that depend on retinal image quality will be affected more by RGP than by SCL lenses. PMID:20601913

  9. Elimination of aniseikonia in monocular aphakia with a contact lens-spectacle combination.

    PubMed

    Schechter, R J

    1978-01-01

    Correction of monocular aphakia with contact lenses generally results in aniseikonia in the range of 7--9%; with correction by intraocular lenses, aniseikonia is approximately 2%. We present a new method of correcting aniseikonia in monocular aphakics using a contact lens-spectacle combination. A formula is derived wherein the contact lens is deliberately overcorrected; this overcorrection is then neutralized by the appropriate spectacle lens, to be worn over the contact lens. Calculated results with this system over a wide range of possible situations consistently results in an aniseikonia of 0.1%.

  10. Not only Gravitational Lensing, but in general Medium Lensing

    NASA Astrophysics Data System (ADS)

    Smarandache, Florentin

    2013-05-01

    According to the General Theory of Relativity the gravity curves the spacetime and everything over there follows a curved path. The space being curved near massive cosmic bodies is just a metaphor, not a fact. We dough that gravity is only geometry. The deflection of light (Gravitational Lensing) near massive cosmic bodies is not due because of a ``curved space'', but because of the medium composition (medium that could be formed by waves, particles, plasma, dust, gaseous, fluids, solids, etc.), to the medium density, medium heterogeneity, and to the electromagnetic and gravitational fields contained in that medium that light passes through. This medium deviates the light direction, because of the interactions of photons with other particles. The space is not empty; it has various nebulae and fields and corpuscles, etc. Light bends not only because of the gravity but also because of the medium gradient and refraction index, similarly as light bends when it leaves or enters a liquid, a plastic, a glass, or a quartz. The inhomogeneous medium may act as an optical lens such that its refractive index varies in a fashion, alike the Gradient-Index Lens. We talk about a Medium Lensing, which means that photons interact with other particles in the medium. For example, the interaction between a photon of electromagnetic radiation with a charged particle (let's say with a free electron), which is known as Compton Effect, produces an increase in the photon's wavelength. In the Inverse Compton Effect the low-energy photons gain energy because they were scattered by much-higher energy free electrons.

  11. Fitting an MSD (mini scleral design) rigid contact lens in advanced keratoconus with INTACS.

    PubMed

    Dalton, Kristine; Sorbara, Luigina

    2011-12-01

    Keratoconus is a bilateral degenerative disease characterized by a non-inflammatory, progressive central corneal ectasia (typically asymmetric) and decreased vision. In its early stages it may be managed with spectacles and soft contact lenses but more commonly it is managed with rigid contact lenses. In advanced stages, when contact lenses can no longer be fit, have become intolerable, or corneal damage is severe, a penetrating keratoplasty is commonly performed. Alternative surgical techniques, such as the use of intra-stromal corneal ring segments (INTACS) have been developed to try and improve the fit of rigid contact lenses in keratoconic patients and avoid penetrating keratoplasties. This case report follows through the fitting of rigid contact lenses in an advanced keratoconic cornea after an INTACS procedure and discusses clinical findings, treatment options, and the use of mini-scleral and scleral lens designs as they relate to the challenges encountered in managing such a patient. Mini-scleral and scleral lenses are relatively easy to fit, and can be of benefit to many patients, including advanced keratoconic patients, post-INTAC patients and post-penetrating keratoplasty patients.

  12. Scanning Miniature Microscopes without Lenses

    NASA Technical Reports Server (NTRS)

    Wang, Yu

    2009-01-01

    The figure schematically depicts some alternative designs of proposed compact, lightweight optoelectronic microscopes that would contain no lenses and would generate magnified video images of specimens. Microscopes of this type were described previously in Miniature Microscope Without Lenses (NPO - 20218), NASA Tech Briefs, Vol. 22, No. 8 (August 1998), page 43 and Reflective Variants of Miniature Microscope Without Lenses (NPO 20610), NASA Tech Briefs, Vol. 26, No. 9 (September 1999), page 6a. To recapitulate: In the design and construction of a microscope of this type, the focusing optics of a conventional microscope are replaced by a combination of a microchannel filter and a charge-coupled-device (CCD) image detector. Elimination of focusing optics reduces the size and weight of the instrument and eliminates the need for the time-consuming focusing operation. The microscopes described in the cited prior articles contained two-dimensional CCDs registered with two-dimensional arrays of microchannels and, as such, were designed to produce full two-dimensional images, without need for scanning. The microscopes of the present proposal would contain one-dimensional (line image) CCDs registered with linear arrays of microchannels. In the operation of such a microscope, one would scan a specimen along a line perpendicular to the array axis (in other words, one would scan in pushbroom fashion). One could then synthesize a full two-dimensional image of the specimen from the line-image data acquired at one-pixel increments of position along the scan. In one of the proposed microscopes, a beam of unpolarized light for illuminating the specimen would enter from the side. This light would be reflected down onto the specimen by a nonpolarizing beam splitter attached to the microchannels at their lower ends. A portion of the light incident on the specimen would be reflected upward, through the beam splitter and along the microchannels, to form an image on the CCD. If the

  13. Acanthamoeba keratitis associated with tap water use during contact lens cleaning: manufacturer guidelines need to change.

    PubMed

    Legarreta, John E; Nau, Amy C; Dhaliwal, Deepinder K

    2013-03-01

    Contact lens-associated Acanthamoeba keratitis continues to be a significant cause of visual morbidity in the United States. Although exposure to water sources while wearing lenses has been a known risk factor for infection for decades, this behavior in several contact lens hygiene protocols continues to prevail. In this review, we surveyed the currently available contact lens cleaning solutions for both soft and rigid gas-permeable contact lenses and reviewed the cleaning instructions of the available solutions. Discrepancies between clinician recommendations and written instructions on a solution packages continues to persist, and we advocate a revision in current manufacturer guidelines to include explicit warnings against use of tap or distilled water sources for cleaning contact lenses or their storage cases.

  14. In Situ Visualization of Tears on Contact Lens Using Ultra High Resolution Optical Coherence Tomography

    PubMed Central

    Wang, Jianhua; Jiao, Shuliang; Ruggeri, Marco; Shousha, Mohammed Abou; Chen, Qi

    2012-01-01

    Objective To demonstrate the capability of directly visualizing the tear film on contact lenses using optical coherence tomography (OCT). Methods Six eyes of three healthy subjects wearing PureVision and ACUVUE Advance soft and Boston RGP hard contact lenses were imaged with a custom built, high speed, ultra-high resolution spectral domain optical coherence tomograph. Refresh Liquigel was used to demonstrate the effect of artificial tears on the tear film. Results Ultra high resolution images of the pre- and post-lens films were directly visualized when each lens was inserted onto the eye. After the instillation of artificial tears during lens wear, the tear film was thicker. The post-lens tear film underneath the lens edge was clearly shown. Interactions between the lens edges and the ocular surface were obtained for each of the lens types and base curves. With a contrast enhancement agent, tear menisci on the contact lenses around the upper and lower eyelids were highlighted. With hard contact lenses, the tear film was visualized clearly and changed after a blink when the lens was pulled up by the lid. Conclusions Ultra-high resolution OCT is a potentially promising technique for imaging tears around contact lenses. This successful demonstration of in situ post-lens tear film imaging suggests that OCT could open a new era in studying tear dynamics during contact lens wear. The novel method may lead to new ways of evaluating contact lens fitting. PMID:19265323

  15. The Infant Aphakia Treatment Study Contact Lens Experience: One-Year Outcomes

    PubMed Central

    Russell, Buddy; Ward, Michael A.; Lynn, Michael; DuBois, Lindreth; Lambert, Scott R.

    2012-01-01

    Purpose We describe our experience correcting a cohort of infants with contact lenses in the Infant Aphakia Treatment Study (IATS). Materials and Methods Fifty-seven infants 1 to 6 months of age were randomized to contact lens wear. An examination under anesthesia was performed at the time of enrollment and at approximately 1 year of age. A traveling examiner assessed visual acuity at approximately 1 year of age. Results Forty-two treated eyes (74 %) were fitted with silicone elastomer (SE) contact lenses; twelve eyes (21 %) with rigid gas permeable (RGP) contact lenses and three eyes (5%) wore both lens types. Median visual acuity was +0.80 logMAR in both lens type-wearing groups. The mean (± SD) keratometric power of the treated eyes was 46.3 ± 2.8 D at baseline and 44.6 ± 2.3 D at one year of age for a mean decrease of 0.2 ± 0.2 D/mo. Keratometric astigmatism of treated eyes was 1.98 ± 1.37 D at baseline and 1.62 ± 0.98 D at one year of age for a mean decrease of 0.05 ± 0.2 D/mo. The mean RGP lens base curve at baseline was 47.62 D ±2.62 D vs 47.00 D ± 3.50 D at 12 months after surgery. Children wearing SE lenses required a mean of 10.9 replacements (range 2–24) compared to 16.8 replacements (range 8–32) for children wearing RGP lenses. Three adverse events occurred. Conclusions Contact lenses were worn successfully with relatively few adverse events by a cohort of infants with unilateral aphakia. The visual acuity results were identical independent of the contact lens material or modality. RGP lenses needed replacement more often than SE lenses. PMID:22669008

  16. CONSTRAINING SOURCE REDSHIFT DISTRIBUTIONS WITH GRAVITATIONAL LENSING

    SciTech Connect

    Wittman, D.; Dawson, W. A.

    2012-09-10

    We introduce a new method for constraining the redshift distribution of a set of galaxies, using weak gravitational lensing shear. Instead of using observed shears and redshifts to constrain cosmological parameters, we ask how well the shears around clusters can constrain the redshifts, assuming fixed cosmological parameters. This provides a check on photometric redshifts, independent of source spectral energy distribution properties and therefore free of confounding factors such as misidentification of spectral breaks. We find that {approx}40 massive ({sigma}{sub v} = 1200 km s{sup -1}) cluster lenses are sufficient to determine the fraction of sources in each of six coarse redshift bins to {approx}11%, given weak (20%) priors on the masses of the highest-redshift lenses, tight (5%) priors on the masses of the lowest-redshift lenses, and only modest (20%-50%) priors on calibration and evolution effects. Additional massive lenses drive down uncertainties as N{sub lens}{sup -1/2}, but the improvement slows as one is forced to use lenses further down the mass function. Future large surveys contain enough clusters to reach 1% precision in the bin fractions if the tight lens-mass priors can be maintained for large samples of lenses. In practice this will be difficult to achieve, but the method may be valuable as a complement to other more precise methods because it is based on different physics and therefore has different systematic errors.

  17. Investigations of galaxy clusters using gravitational lensing

    NASA Astrophysics Data System (ADS)

    Wiesner, Matthew P.

    In this dissertation, we discuss the properties of galaxy clusters that have been determined using strong and weak gravitational lensing. A galaxy cluster is a collection of galaxies that are bound together by the force of gravity, while gravitational lensing is the bending of light by gravity. Strong lensing is the formation of arcs or rings of light surrounding clusters and weak lensing is a change in the apparent shapes of many galaxies. In this work we examine the properties of several samples of galaxy clusters using gravitational lensing. In Chapter 1 we introduce astrophysical theory of galaxy clusters and gravitational lensing. In Chapter 2 we examine evidence from our data that galaxy clusters are more concentrated than cosmology would predict. In Chapter 3 we investigate whether our assumptions about the number of galaxies in our clusters was valid by examining new data. In Chapter 4 we describe a determination of a relationship between mass and number of galaxies in a cluster at higher redshift than has been found before. In Chapter 5 we describe a model of the mass distribution in one of the ten lensing systems discovered by our group at Fermilab. Finally in Chapter 6 we summarize our conclusions.

  18. Investigations of Galaxy Clusters Using Gravitational Lensing

    SciTech Connect

    Wiesner, Matthew P.

    2014-08-01

    In this dissertation, we discuss the properties of galaxy clusters that have been determined using strong and weak gravitational lensing. A galaxy cluster is a collection of galaxies that are bound together by the force of gravity, while gravitational lensing is the bending of light by gravity. Strong lensing is the formation of arcs or rings of light surrounding clusters and weak lensing is a change in the apparent shapes of many galaxies. In this work we examine the properties of several samples of galaxy clusters using gravitational lensing. In Chapter 1 we introduce astrophysical theory of galaxy clusters and gravitational lensing. In Chapter 2 we examine evidence from our data that galaxy clusters are more concentrated than cosmology would predict. In Chapter 3 we investigate whether our assumptions about the number of galaxies in our clusters was valid by examining new data. In Chapter 4 we describe a determination of a relationship between mass and number of galaxies in a cluster at higher redshift than has been found before. In Chapter 5 we describe a model of the mass distribution in one of the ten lensing systems discovered by our group at Fermilab. Finally in Chapter 6 we summarize our conclusions.

  19. Immunoglobulin Concentration in Tears of Contact Lens Wearers

    PubMed Central

    Maurya, Rajendra P.; Bhushan, Prashant; Singh, Virendra P.; Singh, Mahendra K.; Kumar, Prakash; Bhatia, Ravindra P.S.; Singh, Usha

    2014-01-01

    Purpose: To evaluate changes in the concentration of tear immunoglobulins in contact lens wearers. Methods: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method. Results: Most of the cases used soft (56.6%) and semi-soft gas permeable (30.4%) contact lenses. Tear IgM was detected in only 17.4% and tear IgG in 43.6% of contact lens wearers, while in controls IgG was detected in 9.1% but none of the controls had IgM. There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl). Rise of tear IgA was more in symptomatic patients (15.38 ± 5.28 mg/dl) and in those wearing hard (19.73 ± 5.43 mg/dl) and semi-soft contact lenses (13.31 ± 5.43 mg/dl). A significant increase in tear IgA was noticed in subjects wearing lenses for >3 years (15.69 ± 5.39 mg/dl). About 43.4% of lens wearers were symptomatic and 80% of their lenses showed deposits and/or haziness. All cases with IgM in tear were symptomatic. Conclusion: The relation of immunoglobulin concentration with increasing duration of wear and material of contact lens shows that tear immunoglobulin rise accrues due to mechanical stimulation, hence contact lenses should not be used for a long period and lenses of hard nature should be discouraged. The maintenance, cleaning and deproteinization of the lenses are of high importance to avoid immunostimulation. PMID:25667732

  20. Natural wormholes as gravitational lenses

    SciTech Connect

    Cramer, J.G.; Forward, R.L.; Morris, M.S.; Visser, M.; Benford, G.; Landis, G.A. Forward Unlimited, P.O. Box 2783, Malibu, California 90265 Department of Physics and Astronomy, Butler University, Indianapolis, Indiana 46208 Physics Department, Washington University, St. Louis, Missouri 63130-4899 Physics Department, University of California at Irvine, Irvine, California 92717-4575 NASA Lewis Research Center, Mail Code 302-1, Cleveland, Ohio 44135-3191 )

    1995-03-15

    Once quantum mechanical effects are included, the hypotheses underlying the positive mass theorem of classical general relativity fail. As an example of the peculiarities attendant upon this observation, a wormhole mouth embedded in a region of high mass density might accrete mass, giving the other mouth a net [ital negative] mass of unusual gravitational properties. The lensing of such a gravitationally negative anomalous compact halo object (GNACHO) will enhance background stars with a time profile that is observable and qualitatively different from that recently observed for massive compact halo objects (MACHO's) of positive mass. While the analysis is discussed in terms of wormholes, the observational test proposed is more generally a search for compact negative mass objects of any origin. We recommend that MACHO search data be analyzed for GNACHO's.

  1. Nanoparticle-Laden Contact Lens for Controlled Ocular Delivery of Prednisolone: Formulation Optimization Using Statistical Experimental Design.

    PubMed

    ElShaer, Amr; Mustafa, Shelan; Kasar, Mohamad; Thapa, Sapana; Ghatora, Baljit; Alany, Raid G

    2016-04-20

    Human eye is one of the most accessible organs in the body, nonetheless, its physiology and associated precorneal factors such as nasolacrimal drainage, blinking, tear film, tear turnover, and induced lacrimation has significantly decreased the residence time of any foreign substances including pharmaceutical dosage forms. Soft contact lenses are promising delivery devices that can sustain the drug release and prolong residence time by acting as a geometric barrier to drug diffusion to tear fluid. This study investigates experimental parameters such as composition of polymer mixtures, stabilizer and the amount of active pharmaceutical ingredient on the preparation of a polymeric drug delivery system for the topical ocular administration of Prednisolone. To achieve this goal, prednisolone-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by single emulsion solvent evaporation method. Prednisolone was quantified using a validated high performance liquid chromatography (HPLC) method. Nanoparticle size was mostly affected by the amount of co-polymer (PLGA) used whereas drug load was mostly affected by amount of prednisolone (API) used. Longer homogenization time along with higher amount of API yielded the smallest size nanoparticles. The nanoparticles prepared had an average particle size of 347.1 ± 11.9 nm with a polydispersity index of 0.081. The nanoparticles were then incorporated in the contact lens mixture before preparing them. Clear and transparent contact lenses were successfully prepared. When the nanoparticle (NP)-loaded contact lenses were compared with control contact lenses (unloaded NP contact lenses), a decrease in hydration by 2% (31.2% ± 1.25% hydration for the 0.2 g loaded NP contact lenses) and light transmission by 8% (unloaded NP contact lenses 94.5% NP 0.2 g incorporated contact lenses 86.23%). The wettability of the contact lenses remained within the desired value (<90 °C) even upon incorporation of the NP. NP alone and

  2. Nanoparticle-Laden Contact Lens for Controlled Ocular Delivery of Prednisolone: Formulation Optimization Using Statistical Experimental Design

    PubMed Central

    ElShaer, Amr; Mustafa, Shelan; Kasar, Mohamad; Thapa, Sapana; Ghatora, Baljit; Alany, Raid G.

    2016-01-01

    Human eye is one of the most accessible organs in the body, nonetheless, its physiology and associated precorneal factors such as nasolacrimal drainage, blinking, tear film, tear turnover, and induced lacrimation has significantly decreased the residence time of any foreign substances including pharmaceutical dosage forms. Soft contact lenses are promising delivery devices that can sustain the drug release and prolong residence time by acting as a geometric barrier to drug diffusion to tear fluid. This study investigates experimental parameters such as composition of polymer mixtures, stabilizer and the amount of active pharmaceutical ingredient on the preparation of a polymeric drug delivery system for the topical ocular administration of Prednisolone. To achieve this goal, prednisolone-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by single emulsion solvent evaporation method. Prednisolone was quantified using a validated high performance liquid chromatography (HPLC) method. Nanoparticle size was mostly affected by the amount of co-polymer (PLGA) used whereas drug load was mostly affected by amount of prednisolone (API) used. Longer homogenization time along with higher amount of API yielded the smallest size nanoparticles. The nanoparticles prepared had an average particle size of 347.1 ± 11.9 nm with a polydispersity index of 0.081. The nanoparticles were then incorporated in the contact lens mixture before preparing them. Clear and transparent contact lenses were successfully prepared. When the nanoparticle (NP)-loaded contact lenses were compared with control contact lenses (unloaded NP contact lenses), a decrease in hydration by 2% (31.2% ± 1.25% hydration for the 0.2 g loaded NP contact lenses) and light transmission by 8% (unloaded NP contact lenses 94.5% NP 0.2 g incorporated contact lenses 86.23%). The wettability of the contact lenses remained within the desired value (<90 °C) even upon incorporation of the NP. NP alone and

  3. Tevatron Electron Lenses: Design and Operation

    SciTech Connect

    Shiltsev, Vladimir; Bishofberger, Kip; Kamerdzhiev, Vsevolod; Kozub, Sergei; Kufer, Matthew; Kuznetsov, Gennady; Martinez, Alexander; Olson, Marvin; Pfeffer, Howard; Saewert, Greg; Scarpine, Vic; /Fermilab /SLAC /Fermilab /Serpukhov, IHEP /Novosibirsk, IYF /Serpukhov, IHEP /Fermilab

    2008-08-01

    The beam-beam effects have been the dominating sources of beam loss and lifetime limitations in the Tevatron proton-antiproton collider [1]. Electron lenses were originally proposed for compensation of electromagnetic long-range and head-on beam-beam interactions of proton and antiproton beams [2]. Results of successful employment of two electron lenses built and installed in the Tevatron are reported in [3,4,5]. In this paper we present design features of the Tevatron electron lenses (TELs), discuss the generation of electron beams, describe different modes of operation and outline the technical parameters of various subsystems.

  4. Impression Cytology in Different Types of Contact Lens Users.

    PubMed

    Iskeleli, Guzin; Arici, Ceyhun; Deger Bilgec, Mustafa; Demirkesen, Cuyan; Serap Arslan, Hilal

    2015-01-01

    This study compared tear function tests and cytologic changes on the conjunctival surface in asymptomatic patients wearing contact lens of different materials. Included in this study were 40 eyes wearing daily wear 4 week replacement hydrogel (H) lenses, 32 eyes wearing silicone hydrogel (SiH) lenses, 18 eyes wearing rigid gas-permeable (RGP) lenses, and 21 healthy eyes (no lenses) as the control group. Epithelial morphology of the conjunctival surface was evaluated, based on Nelson classification with conjunctival impression cytology (CIC), after the tear break-up time (TBUT) and Schirmer test were performed. The mean values of the Schirmer and TBUT tests were significantly higher in the control group than in the other lens groups (p < 0.001). Grade 0 was the most frequent CIC in the control group (66.7%) and least frequent in the SiH lens group (40.6%); grade I was least frequent in the control and RGP groups (33.3%) and most frequent in the SiH lens group (40.6%). Moreover, grade 2 was most frequent in the SiH lens group (18.8%). There was no statistically significant difference in goblet cell densities between the groups (p = 0.462). In addition to the different Schirmer and TBUT test results between contact lens wearers and healthy non-wearers, some cytologic changes may occur on the ocular surface with direct mechanical effects of contact lenses. This simple and noninvasive technique may be used to evaluate the ocular surface with regard to intolerance to contact lenses.

  5. An analytical approach to gravitational lensing by an ensemble of axisymmetric lenses

    NASA Technical Reports Server (NTRS)

    Lee, Man Hoi; Spergel, David N.

    1990-01-01

    The problem of gravitational lensing by an ensemble of identical axisymmetric lenses randomly distributed on a single lens plane is considered and a formal expression is derived for the joint probability density of finding shear and convergence at a random point on the plane. The amplification probability for a source can be accurately estimated from the distribution in shear and convergence. This method is applied to two cases: lensing by an ensemble of point masses and by an ensemble of objects with Gaussian surface mass density. There is no convergence for point masses whereas shear is negligible for wide Gaussian lenses.

  6. Wearable telescopic contact lens.

    PubMed

    Arianpour, Ashkan; Schuster, Glenn M; Tremblay, Eric J; Stamenov, Igor; Groisman, Alex; Legerton, Jerry; Meyers, William; Amigo, Goretty Alonso; Ford, Joseph E

    2015-08-20

    We describe the design, fabrication, and testing of a 1.6 mm thick scleral contact lens providing both 1× and 2.8× magnified vision paths, intended for use as a switchable eye-borne telescopic low-vision aid. The F/9.7 telescopic vision path uses an 8.2 mm diameter annular entrance pupil and 4 internal reflections in a polymethyl methacrylate precision optic. This gas-impermeable insert is contained inside a smooth outer casing of rigid gas-permeable polymer, which also provides achromatic correction for refraction at the curved lens face. The unmagnified F/4.1 vision path is through the central aperture of the lens, with additional transmission between the annular telescope rings to enable peripheral vision. We discuss potential solutions for providing oxygenation for an extended wear version of the lens. The prototype lenses were characterized using a scale-model human eye, and telescope functionality was confirmed in a small-scale clinical (nondispensed) demonstration.

  7. Thermal lensing in a supercritical water medium.

    PubMed

    Rodriguez, Rene G; Mezyk, Stephen P; Stewart, Charlynn; Rollins, Harry W; Mincher, Bruce J; Fox, Robert V; Phillips, BarJean; Brey, Richard

    2007-01-25

    A pulsed, two-beam, thermal lensing experiment was performed to determine the concentration of aqueous solutes above the critical point of water. Despite a very significant mirage effect due to thermal gradients in the cell and absorption by water itself, the thermal lensing signal strength for aqueous benzoic acid in supercritical water was found to be linear with concentration in the sub-millimolar range. Although thermal lensing experiments in aqueous media are notoriously insensitive, the sharp density gradient near the critical point considerably improves the signal intensity. In this study a short-pulse pump 266 nm YAG laser and continuous low-power probe Ar ion beam were both focused into a supercritical water cell, giving a lensing signal whose strength could be maximized by changing the overlap of the two beams.

  8. Light diffraction by concentrator Fresnel lenses.

    PubMed

    Hornung, Thorsten; Nitz, Peter

    2014-05-05

    Fresnel lenses are widely used in concentrating photovoltaic (CPV) systems as primary optical elements focusing sunlight onto small solar cells or onto entrance apertures of secondary optical elements attached to the solar cells. Calculations using the Young-Maggi-Rubinowicz theory of diffraction yield analytical expressions for the amount of light spilling outside these target areas due to diffraction at the edges of the concentrator Fresnel lenses. Explicit equations are given for the diffraction loss due to planar Fresnel lenses with small prisms and due to arbitrarily shaped Fresnel lenses. Furthermore, the cases of illumination by monochromatic, polychromatic, totally spatially coherent and partially spatially coherent light (e.g. from the solar disc) are treated, resulting in analytical formulae. Examples using realistic values show losses due to diffraction of up to several percent.

  9. Disruption of Contact Lens–Associated Pseudomonas aeruginosa Biofilms Formed in the Presence of Neutrophils

    PubMed Central

    Parks, Quinn M.; Young, Robert L.; Kret, Jennifer; Poch, Katie R.; Malcolm, Kenneth C.; Nichols, David P.; Nichols, Michelle; Zhu, Meifang; Cavanagh, H. Dwight; Nick, Jerry A.

    2011-01-01

    Purpose. To evaluate the capacity of neutrophils to enhance biofilm formation on contact lenses by an infectious Pseudomonas aeruginosa (PA) corneal isolate. Agents that target F-actin and DNA were tested as a therapeutic strategy for disrupting biofilms formed in the setting of neutrophils in vitro and for limiting the infectious bioburden in vivo. Methods. Biofilm formation by infectious PA strain 6294 was assessed in the presence of neutrophils on a static biofilm plate and on unworn etafilcon A soft contact lenses. A d-isomer of poly(aspartic acid) was used alone and with DNase to reduce biofilm formation on test contact lenses. The gentamicin survival assay was used to determine the effectiveness of the test compound in reducing subsequent intracellular bacterial load in the corneal epithelium in a contact lens infection model in the rabbit. Results. In a static reactor and on hydrogel lenses, PA biofilm density was enhanced 30-fold at 24 hours in the presence of neutrophils (P < 0.0001). The combination of DNase and anionic poly(aspartic acid) reduced the PA biofilms formed in the presence of activated neutrophils by 79.2% on hydrogel contact lenses (P < 0.001). An identical treatment resulted in a 41% reduction in internalized PA in the rabbit corneal epithelium after 24 hours (P = 0.03). Conclusions. These results demonstrate that PA can exploit the presence of neutrophils to form biofilm on contact lenses within a short time. Incorporation of F-actin and DNA represent a mechanism for neutrophil-induced biofilm enhancement and are targets for available agents to disrupt pathogenic biofilms formed on contact lenses and as a treatment for established corneal infections. PMID:21245396

  10. Revised Unfilling Procedure for Solid Lithium Lenses

    SciTech Connect

    Leveling, A.; /Fermilab

    2003-06-03

    A procedure for unfilling used lithium lenses to has been described in Pbar Note 664. To date, the procedure has been used to disassemble lenses 20, 21, 17, 18, and 16. As a result of this work, some parts of the original procedure were found to be time consuming and ineffective. Modifications to the original procedure have been made to streamline the process and are discussed in this note. The revised procedure is included in this note.

  11. Measuring neutrino masses with weak lensing

    SciTech Connect

    Wong, Yvonne Y. Y.

    2006-11-17

    Weak gravitational lensing of distant galaxies by large scale structure (LSS) provides an unbiased way to map the matter distribution in the low redshift universe. This technique, based on the measurement of small distortions in the images of the source galaxies induced by the intervening LSS, is expected to become a key cosmological probe in the future. We discuss how future lensing surveys can probe the sum of the neutrino masses at the 0 05 eV level.

  12. Simulating HST observations of strong lensing clusters

    NASA Astrophysics Data System (ADS)

    Meneghetti, Massimo

    2014-10-01

    The Frontier Fields {FF} are using galaxy cluster gravitational lensing to boost the powers of Hubble and Spitzer to reveal the faintest galaxies yet observed. Accurate gravitational lensing models with uncertainty estimates are required to study some of the physical parameters of the lensed galaxies. Simulated HST observations of lensing clusters with known mass distributions are ideal to determine the accuracies of these modeling methods. Our team has begun performing these tests, demonstrating that integrated quantities such as lensed number counts are accurately recovered, enabling luminosity functions to be constrained. We have also begun to quantify magnification uncertainties for individual galaxies, but additional tests are needed. Here we propose to create a set of simulated osbervations of clusters selected to be analogs of the CLASH and FF clusters. They will include lensing effects and they will be delivered to the Mikulski Archive for Space Telescopes as a legacy product for others to analyze. They will be usable to extend our tests for robustly determine the accuracies in model magnification and mass measurements. Mass uncertainties will be a key ingredient in efforts to use galaxy clusters to constrain cosmology and theories of structure formation. Results from this program will also be useful to improve lens modeling methods toward more optimal use of the large numbers of lensing constraints available in deep FF imaging. This program will help astronomers realize the full potential of the large investments of Hubble, Spitzer, Chandra, and ground-based observing time in the FF, CLASH, and other past and future cluster lensing observations.

  13. Electron lenses for particle collimation in LHC

    SciTech Connect

    Shiltsev, v.; /Fermilab

    2007-12-01

    Electron Lenses built and installed in Tevatron have proven themselves as safe and very reliable instruments which can be effectively used in hadron collider operation for a number of applications, including compensation of beam-beam effects [1], DC beam removal from abort gaps [2], as a diagnostic tool. In this presentation we - following original proposal [3] - consider in more detail a possibility of using electron lenses with hollow electron beam for ion and proton collimation in LHC.

  14. Design and some practical applications of ultrasonic transducers with axicon lenses

    NASA Astrophysics Data System (ADS)

    Katchadjian, P.; Desimone, C.; Garcia, A.

    2013-01-01

    In this paper the applications, detailed in previous papers, referred to ultrasonic transducers with the addition of axicon lenses are extended. Axicon lenses, both contact and immersion, for normal and angular incidence were manufactured, in order to study defectology in welds and other components. For immersion transducers, as had already been made for contact transducers, signal amplitude in function of the depth of the reflector and transverse acoustic pressure at the focus were measured. For this purpose a small metallic sphere submerged in different fluids was used. Several practical applications are shown where it is possible to exploit the advantages that these transducers offer: high resolution measurements for corrosion, laminations and thickness reduction. Discrimination between a weld root and a defect very close to it, etc. Measurements in anisotropic materials (composites) in order to achieve an SNR improvement.

  15. Validation of an Off-Eye Contact Lens Shack-Hartmann Wavefront Aberrometer

    PubMed Central

    KOLLBAUM, PETE; JANSEN, MEREDITH; THIBOS, LARRY; BRADLEY, ARTHUR

    2008-01-01

    Purpose To evaluate the ability of a commercially available single pass Shack-Hartmann aberrometer to evaluate contact lens aberrations. Methods Accuracy of second-order aberration measurements was verified by measuring a series of precision calibration lenses, spectacle lenses, and contact lenses. Power measurements were compared to those expected by an independent measurement or those provided by the lens manufacturer. Accuracy of third-order aberrations was verified by systematically decentering a lens with known amounts of spherical aberration and comparing the magnitude of induced coma to that of optical theory. Fourth-order aberration accuracy was verified by comparing measured longitudinal spherical aberration values to those expected by ray tracing based on the lens design. Accuracy of lower- and higher-order aberrations was verified for measurements of lenses taken in air and within a saline-filled wet cell. Repeatability was also assessed by comparing repeated measurements of the wet cell and lens in a wet cell, before and after manipulation of that cell. Results In all cases, measured values closely matched the expected values, generally exhibiting errors of <1%. Conclusions The instrument demonstrates good accuracy and repeatability in measuring second-, third-, and fourth-order aberrations of contact lenses and provides the industry with an instrument for evaluating the ex vivo optical characteristics of contact lenses. PMID:18772713

  16. Cosmological test using strong gravitational lensing systems

    NASA Astrophysics Data System (ADS)

    Yuan, C. C.; Wang, F. Y.

    2015-09-01

    As one of the probes of universe, strong gravitational lensing systems allow us to compare different cosmological models and constrain vital cosmological parameters. This purpose can be reached from the dynamic and geometry properties of strong gravitational lensing systems, for instance, time-delay Δτ of images, the velocity dispersion σ of the lensing galaxies and the combination of these two effects, Δτ/σ2. In this paper, in order to carry out one-on-one comparisons between ΛCDM universe and Rh = ct universe, we use a sample containing 36 strong lensing systems with the measurement of velocity dispersion from the Sloan Lens Advanced Camera for Surveys (SLACS) and Lens Structure and Dynamic survey (LSD) survey. Concerning the time-delay effect, 12 two-image lensing systems with Δτ are also used. In addition, Monte Carlo simulations are used to compare the efficiency of the three methods as mentioned above. From simulations, we estimate the number of lenses required to rule out one model at the 99.7 per cent confidence level. Comparing with constraints from Δτ and the velocity dispersion σ, we find that using Δτ/σ2 can improve the discrimination between cosmological models. Despite the independence tests of these methods reveal a correlation between Δτ/σ2 and σ, Δτ/σ2 could be considered as an improved method of σ if more data samples are available.

  17. Equatorial potassium currents in lenses.

    PubMed

    Wind, B E; Walsh, S; Patterson, J W

    1988-02-01

    Earlier work with the vibrating probe demonstrated the existence of outward potassium currents at the equator and inward sodium currents at the optical poles of the lens. By adding microelectrodes to the system, it is possible to relate steady currents (J) to the potential difference (PD) measured with a microelectrode. By injecting an outward current (I), it is possible to determine resistances and also the PD at which the steady outward potassium current becomes zero (PDJ = 0). At this PD the concentration gradient for potassium efflux and the electrical gradient for potassium influx are balanced so that there is no net flow of potassium across the membranes associated with the production of J. The PDJ = 0 for 18 rat lenses was 86 mV and that for 12 frogs lenses was -95 mV. This agrees with the potassium equilibrium potential and provides strong evidence to support the view that the outward equatorial current, J, is a potassium current. With the injection of outward current, I, the PD becomes more negative, the outward equatorial current, J, decreases, and the inward current at the optical poles increases. This suggests that there are separate electrical loops for K+ and Na+ that are partially linked by the Na, K-pump. Using Ohm's law, it is possible to calculate the input resistance (R = delta PD/I), the resistance related to the production of J (RJ = delta PD/delta J), and the effect of the combined resistances (delta J/I). The driving force for J can be estimated (PDJ = 0-PD). The relationships among currents, voltages and resistance can be used to determine the characteristics of the membranes that are associated with the outward potassium current observed at the equator. The effects of graded deformation of the lens were determined. The effects were reversible. The sites of inward and outward currents were not altered. Following deformation, the equatorial current, J, increased, and the PD became less negative. The PDJ = 0 remains the same so the ratio of K

  18. Contact lens wear and microbial keratitis.

    PubMed

    Ahuja, Markanday

    2002-11-01

    Common types of contact lens are hard, rigid gas-permeable or soft lenses. Most lenses are worn on a daily basis. Cosmetic lenses are worn for non-medical indications. Microbial keratitis, a rare but most significant complication is discussed in this article. Pseudomonas aeruginosa and staphylococci are the most common organisms cause infective keratitis. Fungi and acanthamoeba are also responsible. The causes of increased susceptibility to infection are poor lens hygiene, adhesion of bacteria to lens surface and hypoxia. Preventing measures to be taken while wearing contact lens are discussed in a nutshell. Ocular pain, conjunctival infection, photophobia, epiphora and reduced vision are some of the symptoms of corneal infection. Diagnostic laboratory investigations are to be carried out immediately when a microbial corneal ulcer is suspected. Acanthamoeba can be cultured from corneal scrapes. Immunologically based fluorescein labelling techniques appear to be more sensitive than simple staining. The treatment consists of medical and surgical intervention. Corneal thinning, descemetocele formation and perforation are possible complications.

  19. The mounting system of lenses in ASPIICS coronagraph

    NASA Astrophysics Data System (ADS)

    Veselý, Martin; Vít, Tomáš; Pleštil, Jan

    2016-11-01

    This article describes the mounting system of lenses in a coronagraph ASPIICS (Association of Spacecraft for Polarimetric Imaging Investigation of the Corona of the Sun). ASPIICS is developed and produced in cooperation of twenty partners from seven countries. It is a part of the ESA's PROBA-3 mission, which includes a formation flight of a pair of satellites at orbit. Coronagraph itself consists of three objectives, where the last one is composed by one objective tube for each lens plus holder and Lyot stop. To achieve high accuracy of mounting of the individual lenses, it was necessary to achieve tight geometric and dimensional tolerances for manufacturing of the objectives barrels. In order to minimize the stress and to prevent the displacement of the lens from ideal position during a temperature change on orbit, an athermal solution was proposed. This is achieved by inserting a Teflon ring of a suitable thickness between the lens surface, objective barrel and the spring washer with a precisely defined contact force. It was necessary to find a suitable technological process of manufacturing, because of the specific behavior of PTFE during turning and complex design of other parts. All parameters of mounting system were repeatedly verified by a thermomechanical analysis in FEM software, based on tests of real parts.

  20. Aberration correction of zoom lenses using evolutionary programming.

    PubMed

    Pal, Sourav

    2013-08-10

    A systematic approach for the aberration correction of zoom systems is presented. It is assumed that the powers and movements of the components of the zoom systems are known. Each component is considered as a system of thin lenses in contact. An evolutionary algorithm is developed to explore the multivariate hyperspace of design variables formed by spherical aberration, central coma, and longitudinal chromatic aberration of each component for infinite conjugate. The primary aberrations for each component at any zoom position are deduced from three central aberration coefficients of the component for infinite conjugate using conjugate shift formulas. Overall system aberrations of the zoom systems are determined by using stop shift formulas. In most of the zoom lens systems it is important to achieve stability in the primary aberrations of the system over the zoom range. This is facilitated by proper formulation of the merit function for the optimization process. Investigations have been carried out on four-component zoom lenses, and an ab initio structure of a four-component zoom lens is presented.

  1. Contact hysteroscopy.

    PubMed

    Baggish, M S; Barbot, J

    1983-06-01

    In 1907 innovations in optics and illumination made by Maximilian Nitze were applied to hysteroscopy by Charles David, who wrote a treatise of hysteroscopy. David improved illumination by placing an electric incandescent bulb at the intrauterine end of his endoscope and also sealed the distal end of the tube with a piece of glass. The history of the contact endoscope that the authors personally used is connected to the invention by Vulmiere (1952) of a revolutionary illumination process in endoscopy--the "cold light" process. The components of cold light consist of a powerful external light source that is transmitted via a special optical guide into the endometrial cavity. The 1st application of his principle (1963) was an optical trochar contained in a metallic sheath. This simple endoscope was perfected, and in 1973 Barbot and Parent, in France, began to use it to examine the uterine cavity. Discussion focuses on methods, instrumentation, method for examination (grasping the instrument, setup, light source, anesthesia, dilatation, technique, and normal endometrium); cervical neoplasia; nonneoplastic lesions of the endometrium (endometrial polyp, submucous myoma, endometrial hyperplasia); intrauterine device localization; neoplastic lesions of the endometrium; precursors (adenocarcinoma); hysteroscopy in pregnancy (embryoscopy, hydatidiform mole, postpartum hemorrhage, incomplete abortion, spontaneous abortion, induced abortions, and amnioscopy); and examinations of children and infants. The contact endoscope must make light contact with the structure to be viewed. The principles of contact endoscopy depend on an interpretation of color, contour, vascular pattern, and a sense of touch. These are computed together and a diagnosis is made on the basis of previously learned clinical pathologic correlations. The contact endoscope is composed of 3 parts: an optical guide; a cylindric chamber that collects and traps ambient light; and a magnifying eyepiece. The phase of

  2. Historical challenge of large lenses

    NASA Astrophysics Data System (ADS)

    Johnson, Kevin L.

    2002-02-01

    To present a full account of the developments in the manufacture of large lenses one needs to address wider issues rather than just provide a catalogue of technological progress. The advances in glass manufacture and improvement in optical techniques have to be considered in relation to the cultural, social and economic factors that have determined where, how and why large lens manufacture developed in specific countries. The challenge facing historians trying to tackle this technological theme, is that it is often poorly documented and little is preserved in the historical records. Until relatively recent times, opticians have concealed their methods, trade secrecy being an important economic strategy. To provide an example, it should be noted that although William Herschel produced the best optics and telescopes of the day, he published practically nothing about his methods. What has been gleaned of his techniques has only been uncovered by careful study of surviving manuscript sources and measurement of his surviving optics. Such was William's personal knowledge, that his son John had to take instruction from his father to refurbish William Herschel's 20-foot telescope. This training gave John tacit knowledge of William's methods and allowed him to successfully undertake his cape observations in the Southern Hemisphere. In spite of the shortcomings of the historical record, historians can give a measured account of the developments of lens optics by studying surviving telescopes and their optics.

  3. Route visualization using detail lenses.

    PubMed

    Karnick, Pushpak; Cline, David; Jeschke, Stefan; Razdan, Anshuman; Wonka, Peter

    2010-01-01

    We present a method designed to address some limitations of typical route map displays of driving directions. The main goal of our system is to generate a printable version of a route map that shows the overview and detail views of the route within a single, consistent visual frame. Our proposed visualization provides a more intuitive spatial context than a simple list of turns. We present a novel multifocus technique to achieve this goal, where the foci are defined by points of interest (POI) along the route. A detail lens that encapsulates the POI at a finer geospatial scale is created for each focus. The lenses are laid out on the map to avoid occlusion with the route and each other, and to optimally utilize the free space around the route. We define a set of layout metrics to evaluate the quality of a lens layout for a given route map visualization. We compare standard lens layout methods to our proposed method and demonstrate the effectiveness of our method in generating aesthetically pleasing layouts. Finally, we perform a user study to evaluate the effectiveness of our layout choices.

  4. Surface Modification of Intraocular Lenses

    PubMed Central

    Huang, Qi; Cheng, George Pak-Man; Chiu, Kin; Wang, Gui-Qin

    2016-01-01

    Objective: This paper aimed to review the current literature on the surface modification of intraocular lenses (IOLs). Data Sources: All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect. Study Selection: The articles on the surface modification of IOLs were included, but those on design modification and surface coating were excluded. Results: Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly (ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of IOLs had led to a better biocompatibility in both in vitro and animal experiments. Conclusion: The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs. PMID:26830993

  5. Multi-wavelength applications of gravitational lensing

    NASA Astrophysics Data System (ADS)

    Fadely, Ross

    2010-12-01

    Using an array of multi-wavelength data, we examine a variety of astrophysical problems with gravitational lensing. First, we seek to understand the mass distribution of an early-type galaxy with an analysis of the lens Q0957+561. We dissect the lens galaxy into luminous and dark components, and model the environment using results from weak lensing. Combining constraints from newly-discovered lensed images and stellar population models, we find the lens has a density profile which is shallower than isothermal, unlike those of typical early-type galaxies. Finally, using the measured time delay between the quasar images we find the Hubble constant to be H 0 = 79.3+6.7-8.5 km s-1 Mpc-1 . One intriguing application of lensing is to exploit the lens magnification boost to study high-redshift objects in greater detail than otherwise possible. Here, we analyze the mid-infrared properties of two lensed z ˜ 2 star-forming galaxies, SDSS J120602.09+514229.5 and SDSS J090122.37+181432.3, using Spitzer /IRS spectra to study their rest-frame ˜ 5-12 μm emission. Both systems exhibit strong polycyclic aromatic hydrocarbon (PAH) features in the spectra, indicating strong star formation and the absence of significant AGN activity. For SDSS J090122.37+181432.3, this detection belies that inferred from optical measurements, indicating mid-IR spectroscopy provides key information needed to understand the properties of high-redshift star-forming galaxies. While lensing provides measurements of the macroscopic properties of lens systems, it can also shed light on small-scale structure of galaxies. To identify and understand lens substructure, we examine the multi-wavelength properties of flux ratios for six lenses. Variations of the flux ratios with wavelength can be used to study the lensed quasars and the small-scale mass distribution of lens galaxies. We detect strong multi-wavelength variations in the lenses HE 0435-1223 and SDSS 0806+2006. For HE 0435-1223, we study its

  6. Are hard lenses superior to soft? The advantages of soft lenses.

    PubMed

    Yamane, S J

    1990-01-01

    Soft lenses now account for 85% of all lens sales in the United States and 74% of all sales worldwide. Several factors account for their popularity with patients, practitioners, and lens manufacturers. For patients, soft lenses offer easier adaptation, greater comfort, better appearance, less nighttime flare and spectacle blur, more flexibility in wearing schedule, and less chance of lens loss than polymethylmethacrylate (PMMA) or rigid gas-permeable lenses. Soft lenses also provide the options of disposability and of iris color change. Practitioners prefer soft lenses because they are less likely than hard lenses to cause epithelial staining, corneal molding, corneal edema, corneal desensitivity, or lens overwear syndrome. Furthermore, soft lenses present fewer fitting problems, satisfy therapeutic needs, are easier to stock for replacement purposes, and generally require no in-office modifications. Practitioners also welcome the benefits of disposable lenses: a simple lens care regimen, a decreased potential for deposit buildup, and adaptability to many different lifestyles. Manufacturers like the fact that hydrogels can be stock molded, and that their fitting is easier to teach.

  7. STS-40 Payload Specialist Hughes-Fulford inserts contact lens into her eye

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-40 Payload Specialist Millie Hughes-Fulford inserts a contact lens into her eye while on the middeck of Columbia, Orbiter Vehicle (OV) 102. Hughes-Fulford is preparing for Experiment No. 072, Vestibular Experiments in Spacelab. The rotating dome associated with one of this experiment's procedures requires the contact lenses to record eye movements.

  8. Myopia Progression over Three Years of Soft Contact Lens Wear

    PubMed Central

    Blacker, Adam; Mitchell, G. Lynn; Bullimore, Mark. A.; Long, Bill; Dillehay, Sally M.; Bergenske, Peter; Donshik, Peter; Secor, Glenda; Yoakum, John; Chalmers, Robin L

    2009-01-01

    Purpose To analyze the effect of lens material alone on myopia progression in a multi-center non-randomized prospective study of daily wear hydrogel and continuous wear silicone hydrogel contact lenses. Methods Refractive error data from completing subjects was collected during a 3-year study of 54 subjects wearing low Dk/t hydrogel contact lenses for daily wear and 230 wearing silicone hydrogel contact lenses for up to 30 nights continuous wear. Univariate analysis of refractive error changes was first conducted on factors of lens type, age at baseline, and baseline refractive error. Multivariate analysis was then performed to control for potential confounders of age (categorical by decade and continuous), and baseline refractive error. Results Multivariate analysis showed that refractive error changes were significantly affected by lens type (F = 78.2, p < 0.001, R2 = 0.218) and subject age (F = 13.1.2, p < 0.001, R2 = 0.319), but not baseline refractive error (F = 2.56, p = 0.11, R2 = 0.009). The model’s overall R2 value is 0.376; the age-adjusted refractive error changes are +0.02 D for the silicone hydrogel contact lens wearers and 0.41 D for the hydrogel contact lenses for the 3-year follow-up period. Conclusions Subject age and lens type significantly influenced the degree of myopic progression, with younger subjects and low Dk/t hydrogel contact lens wearers increasing more during the study. The Lotrafilcon A silicone hydrogel lens material may contribute to less myopia progression in adult contact lens wearers. PMID:19741563

  9. [The problem of amblyopia in subluxated lenses (author's transl)].

    PubMed

    Schulz, E

    1980-01-01

    A re-evaluation of the incidence and development of amblyopia was carried out in 27 patients with a history of lens subluxation at pre-school age. Due to insufficiently accurate histories and the heterogeneous composition of the material it is impossible to make any valid statement regarding the critical phase of development of deprivation amblyopia. However, it appears that "form-deprivation" amblyopia may regress spontaneously up to early school age following hygienization of the optic media and if optimal spectacles or contact lenses are worn. In individual cases it has been shown that unilateral amblyopias can and should be treated (pleoptics) following hygienization of the optic media. Therefore, early surgical treatment should be considered in such cases, above all in view of the fact that complications are rare.

  10. Precision cosmology with weak gravitational lensing

    NASA Astrophysics Data System (ADS)

    Hearin, Andrew P.

    In recent years, cosmological science has developed a highly predictive model for the universe on large scales that is in quantitative agreement with a wide range of astronomical observations. While the number and diversity of successes of this model provide great confidence that our general picture of cosmology is correct, numerous puzzles remain. In this dissertation, I analyze the potential of planned and near future galaxy surveys to provide new understanding of several unanswered questions in cosmology, and address some of the leading challenges to this observational program. In particular, I study an emerging technique called cosmic shear, the weak gravitational lensing produced by large scale structure. I focus on developing strategies to optimally use the cosmic shear signal observed in galaxy imaging surveys to uncover the physics of dark energy and the early universe. In chapter 1 I give an overview of a few unsolved mysteries in cosmology and I motivate weak lensing as a cosmological probe. I discuss the use of weak lensing as a test of general relativity in chapter 2 and assess the threat to such tests presented by our uncertainty in the physics of galaxy formation. Interpreting the cosmic shear signal requires knowledge of the redshift distribution of the lensed galaxies. This redshift distribution will be significantly uncertain since it must be determined photometrically. In chapter 3 I investigate the influence of photometric redshift errors on our ability to constrain dark energy models with weak lensing. The ability to study dark energy with cosmic shear is also limited by the imprecision in our understanding of the physics of gravitational collapse. In chapter 4 I present the stringent calibration requirements on this source of uncertainty. I study the potential of weak lensing to resolve a debate over a long-standing anomaly in CMB measurements in chapter 5. Finally, in chapter 6 I summarize my findings and conclude with a brief discussion of my

  11. Breaking the imaging symmetry in negative refraction lenses.

    PubMed

    Ma, Changbao; Liu, Zhaowei

    2012-01-30

    Optical lenses are pervasive in various areas of sciences and technologies. It is well known that conventional lenses have symmetrical imaging properties along forward and backward directions. In this letter, we show that hyperbolic plasmonic metamaterial based negative refraction lenses perform as either converging lenses or diverging lenses depending on the illumination directions. New imaging equations and properties that are different from those of all the existing optical lenses are also presented. These new imaging properties, including symmetry breaking as well as the super resolving power, significantly expand the horizon of imaging optics and optical system design.

  12. Forensic Analysis of a Contact Lens in a Murder Case.

    PubMed

    Zwerling, Charles S

    2016-03-01

    Contact lenses have had rare relevance in trials and/or investigations. After 5 years of burial, orbital remnants were retrieved from an exhumed body and subsequently identified as a key piece of material evidence in a murder trial. The exhumed case materials were evaluated under laboratory conditions and were determined to be contact lens remnants. Contact lens fracture and burial simulation studies were performed to provide additional corroboration of the physical findings of the exhumed contact lens remnants. This material evidence was instrumental in providing factual proof refuting the defendant's testimony in the murder trial. A brief history of contact lens composition and use is provided for understanding the methods and observational results. This forensic case study represents the first published documentation of a contact lens from an exhumed body being used in a murder investigation and establishes an operational procedure for future forensic contact lens examinations.

  13. The impact of contact angle on the biocompatibility of biomaterials.

    PubMed

    Menzies, Kara L; Jones, Lyndon

    2010-06-01

    Biomaterials may be defined as artificial materials that can mimic, store, or come into close contact with living biological cells or fluids and are becoming increasingly popular in the medical, biomedical, optometric, dental, and pharmaceutical industries. Within the ophthalmic industry, the best example of a biomaterial is a contact lens, which is worn by approximately 125 million people worldwide. For biomaterials to be biocompatible, they cannot illicit any type of unfavorable response when exposed to the tissue they contact. A characteristic that significantly influences this response is that related to surface wettability, which is often determined by measuring the contact angle of the material. This article reviews the impact of contact angle on the biocompatibility of tissue engineering substrates, blood-contacting devices, dental implants, intraocular lenses, and contact lens materials.

  14. Numerical simulation of gravitational lenses

    NASA Astrophysics Data System (ADS)

    Cherniak, Yakov

    Gravitational lens is a massive body or system of bodies with gravitational field that bends directions of light rays propagating nearby. This may cause an observer to see multiple images of a light source, e.g. a star, if there is a gravitational lens between the star and the observer. Light rays that form each individual image may have different distances to travel, which creates time delays between them. In complex gravitational fields generated by the system of stars, analytical calculation of trajectories and light intensities is virtually impossible. Gravitational lens of two massive bodies, one behind another, are able to create four images of a light source. Furthermore, the interaction between the four light beams can form a complicated interference pattern. This article provides a brief theory of light behavior in a gravitational field and describes the algorithm for constructing the trajectories of light rays in a gravitational field, calculating wave fronts and interference pattern of light. If you set gravitational field by any number of transparent and non- transparent objects (stars) and set emitters of radio wave beams, it is possible to calculate the interference pattern in any region of space. The proposed method of calculation can be applied even in the case of the lack of continuity between the position of the emitting stars and position of the resulting image. In this paper we propose methods of optimization, as well as solutions for some problems arising in modeling of gravitational lenses. The simulation of light rays in the sun's gravitational field is taken as an example. Also caustic is constructed for objects with uniform mass distribution.

  15. Pixelation Effects in Weak Lensing

    NASA Technical Reports Server (NTRS)

    High, F. William; Rhodes, Jason; Massey, Richard; Ellis, Richard

    2007-01-01

    Weak gravitational lensing can be used to investigate both dark matter and dark energy but requires accurate measurements of the shapes of faint, distant galaxies. Such measurements are hindered by the finite resolution and pixel scale of digital cameras. We investigate the optimum choice of pixel scale for a space-based mission, using the engineering model and survey strategy of the proposed Supernova Acceleration Probe as a baseline. We do this by simulating realistic astronomical images containing a known input shear signal and then attempting to recover the signal using the Rhodes, Refregier, and Groth algorithm. We find that the quality of shear measurement is always improved by smaller pixels. However, in practice, telescopes are usually limited to a finite number of pixels and operational life span, so the total area of a survey increases with pixel size. We therefore fix the survey lifetime and the number of pixels in the focal plane while varying the pixel scale, thereby effectively varying the survey size. In a pure trade-off for image resolution versus survey area, we find that measurements of the matter power spectrum would have minimum statistical error with a pixel scale of 0.09' for a 0.14' FWHM point-spread function (PSF). The pixel scale could be increased to 0.16' if images dithered by exactly half-pixel offsets were always available. Some of our results do depend on our adopted shape measurement method and should be regarded as an upper limit: future pipelines may require smaller pixels to overcome systematic floors not yet accessible, and, in certain circumstances, measuring the shape of the PSF might be more difficult than those of galaxies. However, the relative trends in our analysis are robust, especially those of the surface density of resolved galaxies. Our approach thus provides a snapshot of potential in available technology, and a practical counterpart to analytic studies of pixelation, which necessarily assume an idealized shape

  16. The Theory of Multiscale Gravitational Lensing

    NASA Astrophysics Data System (ADS)

    Keeton, Charles

    2005-07-01

    Strong gravitational lensing probes the mass distributions of distant galaxies on scales from tens of kiloparsecs {dark matter halos and "macrolensing"} through parsecs {dark matter substructure and "millilensing"} all the way down to individual stars {"microlensing"}. Wonderful data are now available, thanks in large part to HST. However, the theoretical understanding of lensing on different scales is much less mature, which has complicated efforts to interpret the data. We have begun a comprehensive theoretical study of multiscale lensing, to develop a formalism that will enable us both to interpret existing data and to inspire and guide new observations. In this proposal, we specifically seek to develop the first code that simultaneously includes macro-, milli-, and microlensing. We will then use it to: {1} Find clear observational signatures that reveal the scale{s} being probed in data, and then resolve the debate about whether millilensing truly reveals Cold Dark Matter substructure. {2} Show how observations at different scales can constrain the mass function of stars in lens galaxies, and apply the method to existing HST data for seven distant galaxies. {3} Examine non-linearities that link micro-, milli-, and macrolensing, and use the combined analysis to open a new window on dark matter studies with strong lensing. We will also make the code available to the community as part of PI Keeton's public lensing software.

  17. Plasma lenses for focusing relativistic electron beams

    SciTech Connect

    Govil, R.; Wheeler, S.; Leemans, W.

    1997-04-01

    The next generation of colliders require tightly focused beams with high luminosity. To focus charged particle beams for such applications, a plasma focusing scheme has been proposed. Plasma lenses can be overdense (plasma density, n{sub p} much greater than electron beam density, n{sub b}) or underdense (n{sub p} less than 2 n{sub b}). In overdense lenses the space-charge force of the electron beam is canceled by the plasma and the remaining magnetic force causes the electron beam to self-pinch. The focusing gradient is nonlinear, resulting in spherical aberrations. In underdense lenses, the self-forces of the electron beam cancel, allowing the plasma ions to focus the beam. Although for a given beam density, a uniform underdense lens produces smaller focusing gradients than an overdense lens, it produces better beam quality since the focusing is done by plasma ions. The underdense lens can be improved by tapering the density of the plasma for optimal focusing. The underdense lens performance can be enhanced further by producing adiabatic plasma lenses to avoid the Oide limit on spot size due to synchrotron radiation by the electron beam. The plasma lens experiment at the Beam Test Facility (BTF) is designed to study the properties of plasma lenses in both overdense and underdense regimes. In particular, important issues such as electron beam matching, time response of the lens, lens aberrations and shot-to-shot reproducibility are being investigated.

  18. CMB-lensing beyond the Born approximation

    NASA Astrophysics Data System (ADS)

    Marozzi, Giovanni; Fanizza, Giuseppe; Di Dio, Enea; Durrer, Ruth

    2016-09-01

    We investigate the weak lensing corrections to the cosmic microwave background temperature anisotropies considering effects beyond the Born approximation. To this aim, we use the small deflection angle approximation, to connect the lensed and unlensed power spectra, via expressions for the deflection angles up to third order in the gravitational potential. While the small deflection angle approximation has the drawback to be reliable only for multipoles l lesssim 2500, it allows us to consistently take into account the non-Gaussian nature of cosmological perturbation theory beyond the linear level. The contribution to the lensed temperature power spectrum coming from the non-Gaussian nature of the deflection angle at higher order is a new effect which has not been taken into account in the literature so far. It turns out to be the leading contribution among the post-Born lensing corrections. On the other hand, the effect is smaller than corrections coming from non-linearities in the matter power spectrum, and its imprint on CMB lensing is too small to be seen in present experiments.

  19. Optical performance of multifocal intraocular lenses.

    PubMed

    Holladay, J T; Van Dijk, H; Lang, A; Portney, V; Willis, T R; Sun, R; Oksman, H C

    1990-07-01

    The optical performance of one monofocal and five multifocal lenses was evaluated in the laboratory and photographically. The laboratory testing included determination of the modulation transfer function (MTF), through focus response (TFR), resolution efficiency, and Strehl ratio of each lens. The photographic testing included photographs of the Regan high contrast acuity chart at ten feet with clearest focus and 18 additional photographs in which the image was defocused using minus trial lenses in 0.25 diopter increments. A color photograph of the Kodak color chart was also taken using each lens. All testing was conducted using a 3 mm artificial pupil under ideal implant conditions with no decentration or tilt. The laboratory and photographic results demonstrate that all the multifocal lenses had a two- to three-fold increase in the depth of field with at least a 50% lower contrast in the retinal image. The photographic testing revealed a one to two line better resolution limit with the monofocal lens, which corresponded to the 12% to 41% better MTF cut-off value with the monofocal lens by laboratory testing. The measured resolution efficiencies of all six lenses were comparable. The color photographs revealed color mixing of adjacent colors with the multifocal lenses, whereas the colors appeared unchanged from the original with the monofocal lens.

  20. Integral volumetric imaging using decentered elemental lenses.

    PubMed

    Sawada, Shimpei; Kakeya, Hideki

    2012-11-05

    This paper proposes a high resolution integral imaging system using a lens array composed of non-uniform decentered elemental lenses. One of the problems of integral imaging is the trade-off relationship between the resolution and the number of views. When the number of views is small, motion parallax becomes strongly discrete to maintain the viewing angle. In order to overcome this trade-off, the proposed method uses the elemental lenses whose size is smaller than that of the elemental images. To keep the images generated by the elemental lenses at constant depth, the lens array is designed so that the optical centers of elemental lenses may be located in the centers of elemental images, not in the centers of elemental lenses. To compensate optical distortion, new image rendering algorithm is developed so that undistorted 3D image may be presented with a non-uniform lens array. The proposed design of lens array can be applied to integral volumetric imaging, where display panels are layered to show volumetric images in the scheme of integral imaging.