Eliminating the Lost Time Interval of Law Enforcement to Active Shooter Events in Schools

DTIC Science & Technology

2015-09-01

Bureau of Justice Assistance BJS Bureau of Justice Statistics BPD Blacksburg Police Department CPR cardiopulmonary resuscitation CSP...Big Brother and Big Sisters,11 and the Strengthening Families program.12 The Bureau of Justice Statistics (BJS) released the Indicators of School...result in school transfers or discipline were found to increase delinquency , dropout rate, and increased violence.44 Profiling students in an attempt

Model based verification of the Secure Socket Layer (SSL) Protocol for NASA systems

NASA Technical Reports Server (NTRS)

Powell, John D.; Gilliam, David

2004-01-01

The National Aeronautics and Space Administration (NASA) has tens of thousands of networked computer systems and applications. Software Security vulnerabilities present risks such as lost or corrupted data, information theft, and unavailability of critical systems. These risks represent potentially enormous costs to NASA. The NASA Code Q research initiative 'Reducing Software Security Risk (RSSR) Trough an Integrated Approach' offers formal verification of information technology (IT), through the creation of a Software Security Assessment Instrument (SSAI), to address software security risks.

Target organ damage in primary hypertensive patients: role of the morning heart rate surge.

PubMed

Zhan, Yuliang; Kang, Ting; Wei, Yunfeng

The morning heart rate surge (MHRS) and morning blood pressure surge (MBPS) may be responsible for the high prevalence of cardiovascular events during the morning period. The clinical significance of the MBPS has been well established, but that of the MHRS remains unclear. Thus, we evaluated the association between the MHRS and target organ damage (TOD). A cross-sectional study of 580 hypertensive patients was performed. MHRS and heart rate variability (HRV) were analyzed by 24 h electrocardiogram. TOD was assessed by estimated glomerular filtration rate, carotid intima-media thickness (IMT), and left ventricular mass index. The prevalence of TOD tended to decrease with sleep-trough MHRS (first to fourth quartiles: 71%, 70.3%, 58.6%, and 52.7%, respectively) or prewaking MHRS quartiles (first to fourth quartiles: 65.3%, 73.6%, 61.4%, and 54.2%, respectively), whereas the opposite trend was observed for standard deviation of all normal NN intervals (SDNN). Moreover, sleep-trough MHRS, prewaking MHRS, SDNN, and SDNN index were significantly lower in patients with TOD than in those without TOD. According to four logistic regression models, the associations of prewaking MHRS, SDNN, and SDNN index with TOD were lost after adjustment for age and BP. Patients in the first (≤11.125 bpm) and second sleep-trough MHRS quartiles (11.125-15.75 bpm) had a 1.95-2.06-fold increased risk of TOD compared with those in the fourth quartile (p < 0.05). A blunted sleep-trough MHRS, which may serve as a surrogate marker for autonomic imbalance, was independently associated with TOD in primary hypertensive patients.

For Your Bookshelf.

ERIC Educational Resources Information Center

ASBJ Editors.

2000-01-01

Reviews notable education books: "The Rise and Fall of the American Teenager" (Thomas Hine); "The Big Test" (Nicholas Lemann); "The Educated Child" (William Bennett); "Lost Boys" (James Garbarino); "The Schools Our Children Deserve" (Alfie Kohn); "Ready or Not" (Kay Hymowitz); "High…

Mineralogy of selected sedimentary interbeds at or near the Idaho National Engineering Laboratory, Idaho

USGS Publications Warehouse

Reed, Michael F.; Bartholomay, Roy C.

1994-01-01

The U.S. Geological Survey (USGS) Project Office at the Idaho National Engineering Laboratory (INEL), in cooperation with the U.S. Department of Energy and Idaho State University, analyzed 66 samples from sedimentary interbed cores during a 38-month period beginning in October 1990 to determine bulk and clay mineralogy. These cores had been collected from 19 sites in the Big Lost River Basin, 2 sites in the Birch Creek Basin, and 1 site in the Mud Lake Basin, and were archived at the USGS lithologic core library at the INEL. Mineralogy data indicate that the core samples from the Big Lost River Basin have larger mean and median percentages of quartz, total feldspar, and total clay minerals, but smaller mean and median percentages of calcite than the core samples from the Birch Creek Basin. Core samples from the Mud Lake Basin have abundant quartz, total feldspar, calcite, and total clay minerals.

What's Up There? Well, it's not Superman!

NASA Astrophysics Data System (ADS)

Cannon, Trina

2007-10-01

Projectiles are interesting and often give reason to go to the big field outdoors. But too frequently, a well planned lesson turns to chaos with students scattering and the rockets lost in the brush because no one watched it come down. Here are some inside lessons that get good results, no lost materials and students stay contained for the critical instruction. This is a great preliminary to the outside experience. This is suitable for all grades interested in projectile motion and the control of variables.

Cultural Resources Survey, Harry S. Truman Dam and Reservoir Project, Missouri. Volume 2. Historical Resources: Historical Gazetteer and Mitigation Recommendations.

DTIC Science & Technology

1983-02-01

Arnica -- herb with yellow flowers made into tincture and used as stimulant and curative for bruises and sprains) Now extinct. GH Arthur (Vernon) Village...Bedford • lost influence, renamed Handley. WHA, NHl Bee Branch (Henry) A tributary of Big Creek in the NW Big Creek T. S named for the wild bees so...T. named for its location amid many wild cherry trees. SSR Cherry Grove School (Bates) For flora. SSR S S 0 S 43 0 Cherry Valley School (Cedar) For

Lost Soul or New Dawn? Lifelong Learning Lessons and Prospects from East Asia

ERIC Educational Resources Information Center

Duke, Chris

2015-01-01

Most learning takes place in communities, neighbourhoods and workplaces. Here practical solutions to big problems work or fall down. We may call this the iron law of social learning, recognised in "community development", "community capacity-building", "workplace", "work-based" and…

Big Bang Day : Afternoon Play - Torchwood: Lost Souls

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2009-10-13

Martha Jones, ex-time traveller and now working as a doctor for a UN task force, has been called to CERN where they're about to activate the Large Hadron Collider. Once activated, the Collider will fire beams of protons together recreating conditions a billionth of a second after the Big Bang - and potentially allowing the human race a greater insight into what the Universe is made of. But so much could go wrong - it could open a gateway to a parallel dimension, or create a black hole - and now voices from the past are calling out to peoplemore » and scientists have started to disappear... Where have the missing scientists gone? What is the secret of the glowing man? What is lurking in the underground tunnel? And do the dead ever really stay dead? Lost Souls is a spin-off from the award-winning BBC Wales TV production Torchwood. It stars John Barrowman, Freema Agyeman, Eve Myles, Gareth David-Lloyd, Lucy Montgomery (of Titty Bang Bang) and Stephen Critchlow.« less

Big Bang Day : Afternoon Play - Torchwood: Lost Souls

ScienceCinema

None

2017-12-09

Martha Jones, ex-time traveller and now working as a doctor for a UN task force, has been called to CERN where they're about to activate the Large Hadron Collider. Once activated, the Collider will fire beams of protons together recreating conditions a billionth of a second after the Big Bang - and potentially allowing the human race a greater insight into what the Universe is made of. But so much could go wrong - it could open a gateway to a parallel dimension, or create a black hole - and now voices from the past are calling out to people and scientists have started to disappear... Where have the missing scientists gone? What is the secret of the glowing man? What is lurking in the underground tunnel? And do the dead ever really stay dead? Lost Souls is a spin-off from the award-winning BBC Wales TV production Torchwood. It stars John Barrowman, Freema Agyeman, Eve Myles, Gareth David-Lloyd, Lucy Montgomery (of Titty Bang Bang) and Stephen Critchlow.

Water resources in the Big Lost River Basin, south-central Idaho

USGS Publications Warehouse

Crosthwaite, E.G.; Thomas, C.A.; Dyer, K.L.

1970-01-01

The Big Lost River basin occupies about 1,400 square miles in south-central Idaho and drains to the Snake River Plain. The economy in the area is based on irrigation agriculture and stockraising. The basin is underlain by a diverse-assemblage of rocks which range, in age from Precambrian to Holocene. The assemblage is divided into five groups on the basis of their hydrologic characteristics. Carbonate rocks, noncarbonate rocks, cemented alluvial deposits, unconsolidated alluvial deposits, and basalt. The principal aquifer is unconsolidated alluvial fill that is several thousand feet thick in the main valley. The carbonate rocks are the major bedrock aquifer. They absorb a significant amount of precipitation and, in places, are very permeable as evidenced by large springs discharging from or near exposures of carbonate rocks. Only the alluvium, carbonate rock and locally the basalt yield significant amounts of water. A total of about 67,000 acres is irrigated with water diverted from the Big Lost River. The annual flow of the river is highly variable and water-supply deficiencies are common. About 1 out of every 2 years is considered a drought year. In the period 1955-68, about 175 irrigation wells were drilled to provide a supplemental water supply to land irrigated from the canal system and to irrigate an additional 8,500 acres of new land. Average. annual precipitation ranged from 8 inches on the valley floor to about 50 inches at some higher elevations during the base period 1944-68. The estimated water yield of the Big Lost River basin averaged 650 cfs (cubic feet per second) for the base period. Of this amount, 150 cfs was transpired by crops, 75 cfs left the basin as streamflow, and 425 cfs left as ground-water flow. A map of precipitation and estimated values of evapotranspiration were used to construct a water-yield map. A distinctive feature of the Big Lost River basin, is the large interchange of water from surface streams into the ground and from the ground into the surface streams. Large quantities of water disappear in the Chilly, Darlington, and other sinks and reappear above Mackay Narrows, above Moore Canal heading, and in other reaches. A cumulative summary of water yield upstream from selected points in the basin is as follows : Above Howell Ranch: water yield: 345 cfs; surface water: 310 cfs; ground water: 35 cfs Above. Mackay Narrows water yield: 450 cfs; surface water: 325 cfs; ground water: 75 cfs; crop evapotranspiration: 50 cfs Above Arco: water yield: 650 cfs; surface water: 75 cfs; ground water: 425 cfs; crop evapotranspiration: 150 cfs Ground-water pumping affects streamflow in reaches , where the stream and water table are continuous, but the effects of pumping were not measured except locally. Pumping depletes the total water supply by the. amount of the pumped water that is evapotranspired by crops. The part of the pumped water that is not consumed percolates into the ground or runs off over the land surface to the stream. The estimated 425 cfs that leaves the basin as ground-water flow is more than adequate for present and foreseeable needs. However because much of the outflow occurs at considerable depth, the quantity that is salvageable is unknown. Both the surface and ground waters are of good quality and are suitable for most uses. Although these waters are low in total dissolved solids, they tend to be hard or very hard.

Generation of a Parabolic Trough Collector Efficiency Curve from Separate Measurements of Outdoor Optical Efficiency and Indoor Receiver Heat Loss

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kutscher, C.; Burkholder, F.; Stynes, J. K.

2012-02-01

The thermal efficiency of a parabolic trough collector is a function of both the fraction of direct normal radiation absorbed by the receiver (the optical efficiency) and the heat lost to the environment when the receiver is at operating temperature. The thermal efficiency can be determined by testing the collector under actual operating conditions or by separately measuring these two components. This paper describes how outdoor measurement of the optical efficiency is combined with laboratory measurements of receiver heat loss to obtain the thermal efficiency curve. This paper describes this approach and also makes the case that there are advantagesmore » to plotting collector efficiency versus the difference between the operating temperature and the ambient temperature at which the receiver heat loss was measured divided by radiation to a fractional power (on the order of 1/3 but obtained via data regression) - as opposed to the difference between operating and ambient temperatures divided by the radiation. The results are shown to be robust over wide ranges of ambient temperature, sky temperature, and wind speed.« less

28. MAP SHOWING LOCATION OF ARVFS FACILITY AS BUILT. SHOWS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. MAP SHOWING LOCATION OF ARVFS FACILITY AS BUILT. SHOWS LINCOLN BOULEVARD, BIG LOST RIVER, AND NAVAL REACTORS FACILITY. F.C. TORKELSON DRAWING NUMBER 842-ARVFS-101-2. DATED OCTOBER 12, 1965. INEL INDEX CODE NUMBER: 075 0101 851 151969. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

Small Districts in Big Trouble: How Four Arizona School Systems Responded to Charter Competition.

ERIC Educational Resources Information Center

Hess, Frederick; Maranto, Robert; Milliman, Scott

2001-01-01

Examined the responses to charter school competition of four small Arizona school districts. Overall, districts lost students to charter schools because they did not satisfy significant constituencies. Their responses depended on overall enrollment trends, quality of charter competition, quality of district leadership, and district size. Responses…

Depth to water, 1991, in the Rathdrum Prairie, Idaho; Spokane River valley, Washington; Moscow-Lewiston-Grangeville area, Idaho; and selected intermontane valleys, east-central Idaho

USGS Publications Warehouse

Berenbrock, Charles E.; Bassick, M.D.; Rogers, T.L.; Garcia, S.P.

1995-01-01

This map report illustrates digitally generated depth-to-water zones for the Rathdrum Prairie in Idaho; part of the Spokane River Valley in eastern Washington; and the intermontane valleys of the upper Big Wood, Big Lost, Pahsimeroi, Little Lost, and Lemhi Rivers and Birch Creek in Idaho. Depth to water is 400 to 500 feet below land surface in the northern part of Rathdrum Prairie, 100 to 200 feet below land surface at the Idaho-Washington State line, and 0 to 250 feet below land surface in the Spokane area. Depth to water in the intermontane valleys in east-central Idaho is least (usually less than 50 feet) near streams and increases toward valley margins where mountain-front alluvial fans have formed. Depths to water shown in the Moscow-Lewiston-Grangeville area in Idaho are limited to point data at individual wells because most of the water levels measured were not representative of levels in the uppermost aquifer but of levels in deeper aquifers.

Foul weather friends: big business and health care reform in the 1990s in historical perspective.

PubMed

Swenson, Peter; Greer, Scott

2002-08-01

Existing accounts of the Clinton health reform efforts of the early 1990s neglect to examine how the change in big business reform interests during the short period between the late 1980s and 1994 might have altered the trajectory of compulsory health insurance legislation in Congress. This article explores evidence that big employers lost their early interest in reform because they believed their private remedies for bringing down health cost inflation were finally beginning to work. This had a discouraging effect on reform efforts. Historical analysis shows how hard times during the Great Depression also aligned big business interests with those of reformers seeking compulsory social insurance. Unlike the present case, however, the economic climate did not quickly improve, and the social insurance reform of the New Deal succeeded. The article speculates, therefore, that had employer health expenditures not flattened out, continuing and even growing big business support might have neutralized small business and other opposition that contributed heavily to the failure of reform. Thus in light of the Clinton administration's demonstrated willingness to compromise with business on details of its plan, some kind of major reform might have succeeded.

Schooling for Humanity: When Big Brother Isn't Watching.

ERIC Educational Resources Information Center

Solmitz, David O.

Most educational reform initiatives of the past 20 years are geared towards ensuring that the United States dominates the emerging global economy. What is lost in this rush to the top of the materialist heap is an education for the more enduring human values: creativity, intellectual development, care, social justice, and democracy. In this book,…

Role of endothelin-1 and big endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts.

PubMed

Grover, G J; Sleph, P G; Fox, M; Trippodo, N C

1992-12-01

The effect of endothelin-1 (ET-1) and big ET-1 on coronary flow and contractile function was determined in isolated nonischemic and ischemic rat hearts. Both ET-1 (IC50 = 12 pMol) and big ET-1 (IC50 = 2 nMol) reduced coronary flow in a concentration-dependent manner, although ET-1 was > 100-fold more potent. Both compounds decreased contractility, an effect which was lost when coronary flow was held constant, indicating that ET-1 and big ET-1 decrease contractility secondary to reducing coronary flow. Mechanical reduction in coronary flow to levels equivalent to those seen for ET-1 or big ET-1 caused similar reductions in contractility. Both 30 pMol ET-1 and 10 nMol big ET-1 pretreatment significantly reduced the time to contracture in globally ischemic rat hearts, suggesting a proischemic effect. Phosphoramidon (100 microM, endothelin-converting enzyme inhibitor) and BQ-123 (0.3 microM, ETA receptor antagonist) abolished the preischemic increase in coronary perfusion pressure induced by big ET-1 as well as its proischemic effect, whereas only BQ-123 abolished the cardiac effect of ET-1. Neither phosphoramidon nor BQ-123 had an effect on severity of ischemia when given alone. Phosphoramidon was also given i.v. to rats subjected to coronary occlusion and reperfusion and was found to significantly reduce infarct size 24 hr postischemia. Thus, in isolated rat hearts, big ET-1 appears to be converted to ET-1 and is a potent coronary constrictor.(ABSTRACT TRUNCATED AT 250 WORDS)

Getting By: A "Lost Generation" Member's Local History of the College Extracurriculum

ERIC Educational Resources Information Center

Rohan, Liz

2014-01-01

This article features the diaries and letters of a college student, John Price, who attended Denison University from 1917 to 1921. It shows how Price was pushed and pulled into writing in the extracurriculum by his literacy sponsors, which resulted in his founding a humor magazine as "the jock" took over as "the big man on college…

Subsurface information from eight wells drilled at the Idaho National Engineering Laboratory, southeastern Idaho

USGS Publications Warehouse

Goldstein, F.J.; Weight, W.D.

1982-01-01

The Idaho National Engineering Laboratory (INEL) covers about 890 square miles of the eastern Snake River Plain, in southeastern Idaho. The eastern Snake River Plain is a structural basin which has been filled with thin basaltic lava flows, rhyolitic deposits, and interbedded sediments. These rocks form an extensive ground-water reservoir known as the Snake River Plain aquifer. Six wells were drilled and two existing wells were deepened at the INEL from 1969 through 1974. Interpretation of data from the drilling program confirms that the subsurface is dominated by basalt flows interbedded with layers of sediment, cinders, and silicic volcanic rocks. Water levels in the wells show cyclic seasonal fluctuations of maximum water levels in winter and minimum water levels in mid-summer. Water levels in three wells near the Big Lost River respond to changes in recharge to the Snake River Plain aquifer from the Big Lost River. Measured water levels in multiple piezometers in one well indicate increasing pressure heads with depth. A marked decline in water levels in the wells since 1977 is attributed to a lack of recharge to the Snake River Plain aquifer.

ARC-1979-A79-7097

NASA Image and Video Library

1979-07-08

Range : 85,000 kilometers (53,000 miles) This photo of Jupiter's satellite Ganymede shows ancient cratered terrain. A variety of impact craters of different ages are shown. The brightest craters are the youngest. The ejecta blankets fade with age. The center shows a bright patch that represents the rebounding of the floor of the crater. The dirty ice has lost all topography except for faint circular patterns. Also shown are the 'Callisto type' curved troughs and ridges that mark an ancient enormous impact basin. The basin itself has been destroyed by later geologic processes. Only the ring features are preserved on the ancient surface. Near the bottom of the picture, these curved features are trumcated by the younger grooved terrain.

Deaths from homicides: a historical series.

PubMed

Costa, Flávia Azevedo de Mattos Moura; da Trindade, Ruth França Cizino; dos Santos, Claudia Benedita

2014-01-01

to describe mortality from homicides in Itabuna, in the State of Bahia. study with hybrid, ecological and time-trend design. The mortality coefficients per 1,000 inhabitants, adjusted by the direct technique, proportional mortality by sex and age range, and Potential Years of Life Lost were all calculated. since 2005, the external causes have moved from third to second most-common cause of death, with homicides being responsible for the increase. In the 13 years analyzed, homicides have risen 203%, with 94% of these deaths occurring among the male population. Within this group, the growth occurred mainly in the age range from 15 to 29 years of age. It was ascertained that 83% of the deaths were caused by firearms; 57.2% occurred in public thoroughfares; and 98.4% in the urban zone. In 2012, the 173 homicides resulted in 7,837 potential years of life lost, with each death causing, on average, the loss of 45.3 years. mortality by homicide in a medium-sized city in Bahia reaches levels observed in the big cities of Brazil in the 1980s, evidencing that the phenomenon of criminality - formerly predominant only in the big urban centers - is advancing into the rural area of Brazil, causing changes in the map of violent homicide in Brazil.

Shoreface response and recovery to Hurricane Sandy: Fire Island, NY

USGS Publications Warehouse

Nelson, Timothy R.; Hapke, Cheryl J.; Wang, Ping; Rosati, Julie D.; Cheng, Jun

2015-01-01

The shoreface of Fire Island was extensively modified by Hurricane Sandy and subsequent storms in the following winter months. The changes were evaluated using various morphometrics of the shoreface from four bathymetric surveys, one prior to Hurricane Sandy, and three over the course of twenty months following Sandy. The datasets show that the nearshore bar system moved offshore to deeper water depths following Hurricane Sandy with volume lost from the subaerial beach and surfzone. Following the offshore shift, the nearshore bar system increased in size, the trough deepened, and there has been gradual landward movement of the nearshore bar. The steepening of the upper shoreface, landward translation of the profile, and loss of sediment is indicative of barrier island transgression.

Archaeological Investigations in the Halls-Fowlkes Region South Fork of the Forked Deer River, West Tennessee

DTIC Science & Technology

1985-01-01

Obion-Forked Deer River and Reelfoot -Indian Creek drainages (Smith 1979a), the Mud Creek drainage (Dye 1975), the Cypress Creek drainages (Peterson 1975...sites have been identified by the presence of Palmer, Cypress Creek, Lost Lake , Decatur, Kirk Stemmed, Big Sandy, Plevna, Haywood, Kirk Corner Notched...necessary to clarify this problem. Several different Mississippian phases, including the Walls, Boxtown, Ensley, Tiptonville and Reelfoot phases have

Rinse trough with improved flow

DOEpatents

O'Hern, Timothy J.; Grasser, Thomas W.

1998-01-01

Novel rinse troughs accomplish thorough uniform rinsing. The troughs are suitable for one or more essentially planar objects having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs provide uniform rinse fluid flow over the objects' surfaces to accomplish a more thorough rinse than prior art troughs.

Rinse trough with improved flow

DOEpatents

O`Hern, T.J.; Grasser, T.W.

1998-08-11

Novel rinse troughs accomplish thorough uniform rinsing. The troughs are suitable for one or more essentially planar objects having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs provide uniform rinse fluid flow over the objects` surfaces to accomplish a more thorough rinse than prior art troughs. 5 figs.

Amplitude versus offset analysis to marine seismic data acquired in Nankai Trough, offshore Japan where methane hydrate exists

NASA Astrophysics Data System (ADS)

Hato, M.; Inamori, T.; Matsuoka, T.; Shimizu, S.

2003-04-01

Occurrence of methane hydrates in the Nankai Trough, located off the south-eastern coast of Japan, was confirmed by the exploratory test well drilling conducted by Japan’s Ministry of International Trade and Industry in 1999. Confirmation of methane hydrate has given so big impact to the Japan's future energy strategy and scientific and technological interest was derived from the information of the coring and logging results at the well. Following the above results, Japan National Oil Corporation (JNOC) launched the national project, named as MH21, for establishing the technology of methane hydrate exploration and related technologies such as production and development. As one of the research project for evaluating the total amount of the methane hydrate, Amplitude versus Offset (AVO) was applied to the seismic data acquired in the Nankai Trough area. The main purpose of the AVO application is to evaluate the validity of delineation of methane hydrate-bearing zones. Since methane hydrate is thought to accompany with free-gas in general just below the methane hydrate-bearing zones, the AVO has a possibility of describing the presence of free-gas. The free-gas is thought to be located just below the base of methane hydrate stability zone which is characterized by the Bottom Simulating Reflectors (BSRs) on the seismic section. In this sense, AVO technology, which was developed as gas delineation tools, can be utilized for methane hydrate exploration. The result of AVO analysis clearly shows gas-related anomaly below the BSRs. Appearance of the AVO anomaly has so wide variety. Some of the anomalies might not correspond to the free-gas existence, however, some of them may show free-gas. We are now going to develop methodology to clearly discriminate free-gas from non-gas zone by integrating various types of seismic methods such as seismic inversion and seismic attribute analysis.

Hellsgate Big Game Winter Range Wildlife Mitigation Project : Annual Report 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitney, Richard P.; Berger, Matthew T.; Rushing, Samuel

The Hellsgate Big Game Winter Range Wildlife Mitigation Project (Hellsgate Project) was proposed by the Confederated Tribes of the Colville Reservation (CTCR) as partial mitigation for hydropower's share of the wildlife losses resulting from Chief Joseph and Grand Coulee Dams. At present, the Hellsgate Project protects and manages 57,418 acres (approximately 90 miles2) for the biological requirements of managed wildlife species; most are located on or near the Columbia River (Lake Rufus Woods and Lake Roosevelt) and surrounded by Tribal land. To date we have acquired about 34,597 habitat units (HUs) towards a total 35,819 HUs lost from original inundationmore » due to hydropower development. In addition to the remaining 1,237 HUs left unmitigated, 600 HUs from the Washington Department of Fish and Wildlife that were traded to the Colville Tribes and 10 secure nesting islands are also yet to be mitigated. This annual report for 2008 describes the management activities of the Hellsgate Big Game Winter Range Wildlife Mitigation Project (Hellsgate Project) during the past year.« less

Corrugated pipe adhesive applicator apparatus

DOEpatents

Shirey, R.A.

1983-06-14

Apparatus for coating selected portions of the troughs of a corrugated pipe with an adhesive includes a support disposed within the pipe with a reservoir containing the adhesive disposed on the support. A pump, including a spout, is utilized for supplying the adhesive from the reservoir to a trough of the pipe. A rotatable applicator is supported on the support and contacts the trough of the pipe. The applicator itself is sized so as to fit within the trough, and contacts the adhesive in the trough and spreads the adhesive in the trough upon rotation. A trough shield, supported by the support and disposed in the path of rotation of the applicator, is utilized to prevent the applicator from contacting selected portions of the trough. A locator head is also disposed on the support and provides a way for aligning the spout, the applicator, and the trough shield with the trough. 4 figs.

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir.

PubMed

Chen, Yen-Liang; Abdul Ghafar, Nahdiyah; Karuna, Ratna; Fu, Yilong; Lim, Siew Pheng; Schul, Wouter; Gu, Feng; Herve, Maxime; Yokohama, Fumiaki; Wang, Gang; Cerny, Daniela; Fink, Katja; Blasco, Francesca; Shi, Pei-Yong

2014-02-01

In a recent clinical trial, balapiravir, a prodrug of a cytidine analog (R1479), failed to achieve efficacy (reducing viremia after treatment) in dengue patients, although the plasma trough concentration of R1479 remained above the 50% effective concentration (EC(50)). Here, we report experimental evidence to explain the discrepancy between the in vitro and in vivo results and its implication for drug development. R1479 lost its potency by 125-fold when balapiravir was used to treat primary human peripheral blood mononuclear cells (PBMCs; one of the major cells targeted for viral replication) that were preinfected with dengue virus. The elevated EC(50) was greater than the plasma trough concentration of R1479 observed in dengue patients treated with balapiravir and could possibly explain the efficacy failure. Mechanistically, dengue virus infection triggered PBMCs to generate cytokines, which decreased their efficiency of conversion of R1479 to its triphosphate form (the active antiviral ingredient), resulting in decreased antiviral potency. In contrast to the cytidine-based compound R1479, the potency of an adenosine-based inhibitor of dengue virus (NITD008) was much less affected. Taken together, our results demonstrate that viral infection in patients before treatment could significantly affect the conversion of the prodrug to its active form; such an effect should be calculated when estimating the dose efficacious for humans.

Evaluating connection of aquifers to springs and streams, Great Basin National Park and vicinity, Nevada

USGS Publications Warehouse

Prudic, David E.; Sweetkind, Donald S.; Jackson, Tracie R.; Dotson, K. Elaine; Plume, Russell W.; Hatch, Christine E.; Halford, Keith J.

2015-12-22

Groundwater flow from southern Spring Valley continues through the western side of Hamlin Valley before being directed northeast toward the south end of Snake Valley. This flow is constrained by southward-flowing groundwater from Big Spring Wash and northward-flowing groundwater beneath central Hamlin Valley. The redirection to the northeast corresponds to a narrowing of the width of flow in southern Snake Valley caused by a constriction formed by a steeply dipping middle Paleozoic siliciclastic confining unit exposed in the flanks of the mountains and hills on the east side of southern Snake Valley and shallowly buried beneath basin fill in the valley. The narrowing of groundwater flow could be responsible for the large area where groundwater flows to springs or is lost to evapotranspiration between Big Springs in Nevada and Pruess Lake in Utah.

New Maps of California to Improve Tsunami Preparedness

NASA Astrophysics Data System (ADS)

Barberopoulou, Aggeliki; Borrero, Jose C.; Uslu, Burak; Kalligeris, Nikos; Goltz, James D.; Wilson, Rick I.; Synolakis, Costas E.

2009-04-01

On 25 April 1992, an M 7.1 earthquake shook the coast of Cape Mendocino near Petrolia, Calif., followed by two large aftershocks (both M ˜ 6.6) the next day. Although no lives were lost in these temblors, 98 people were injured. These earthquakes heavily damaged older structures within this sparsely populated, mountainous region, causing more than US$66 million in losses. Approximately 20 minutes after the first earthquake, tide gauge stations in nearby Crescent City reported a surge—a tsunami with maximum wave heights (from trough to crest) of 1.1 meters. The tsunami hit Crescent City and Eureka at low tide. Fortunately, no damages occurred to city or harbor facilities—had this happened during high tide, it may have been a different story [McCarthy et al., 1993].

A resolution honoring the 29 coal miners who perished in the explosion at the Upper Big Branch Mine in Montcoal, West Virginia, on April 5, 2010, and remembering all those who have lost their lives while mining for the resources on which the United States relies.

THOMAS, 112th Congress

Sen. Rockefeller, John D., IV [D-WV

2011-04-04

Senate - 04/05/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

Inhomogeneous Crustal Structure of the Rifting in the Okinawa Trough, a Backarc Basin West of Kyushu, Japan, Deduced from Seismic Reflection and Refraction Data

NASA Astrophysics Data System (ADS)

Nishizawa, A.; Kaneda, K.; Oikawa, M.; Horiuchi, D.; Fujioka, Y.; Okada, C.

2017-12-01

Several depressions found under the thick sediments in the East China Sea shelf have been considered as failed rift basins. Their formation age becomes progressively younger from NW to SE and the youngest rift basin is the Okinawa Trough, an active backarc basin of the Ryukyu (Nansei-Shoto) arc-trench system, to the southwest of Kyusyu, Japan. Its rifting is in progress and related hydrothermal activity is present in the trough. The knowledge of the crustal structure of the trough is fundamental to understand the current active tectonics and predict the future of the trough. We, Japan Coast Guard, have conducted extensive seismic reflection and refraction surveys in the Ryukyu region since 2008 and compiled the seismic structures of the Okinawa Trough. We will show the crustal structures along seven along-trough and ten across-trough seismic survey lines. The P-wave velocity models beneath the Okinawa Trough generally show a thinned continental/island arc crust consisting of upper, middle, and lower crusts. Moho depths below the trough were estimated mainly from Moho reflection (PmP) travel times. The crustal thickness of the trough is thinner than those of the East China Sea shelf and of the Ryukyu Islands. The depth of the Moho below the trough decreases from over 30 km in the north to about 13 km in the south, indicating a difference in degree of the rifting process. The position of the shallowest Moho along the across-trough lines in the northern trough does not necessarily correspond to the center of the trough defined as the deepest water depth, but it corresponds to the transition area between the East China Sea shelf and the Okinawa Trough. An M7.1 earthquake occurred at the transition area on Nov. 14, 2015 (JST) and many aftershocks were observed along the transition. This seismic activity demonstrated that the area is under rifting tectonics in the present.

Directed flow fluid rinse trough

DOEpatents

Kempka, Steven N.; Walters, Robert N.

1996-01-01

Novel rinse troughs accomplish thorough uniform rinsing. The tanks are suitable for one or more essentially planar items having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs also require less rinse fluid to accomplish a thorough rinse than prior art troughs.

Directed flow fluid rinse trough

DOEpatents

Kempka, S.N.; Walters, R.N.

1996-07-02

Novel rinse troughs accomplish thorough uniform rinsing. The tanks are suitable for one or more essentially planar items having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs also require less rinse fluid to accomplish a thorough rinse than prior art troughs. 9 figs.

Patient-reported non-adherence and immunosuppressant trough levels are associated with rejection after renal transplantation.

PubMed

Scheel, Jennifer; Reber, Sandra; Stoessel, Lisa; Waldmann, Elisabeth; Jank, Sabine; Eckardt, Kai-Uwe; Grundmann, Franziska; Vitinius, Frank; de Zwaan, Martina; Bertram, Anna; Erim, Yesim

2017-03-29

Different measures of non-adherence to immunosuppressant (IS) medication have been found to be associated with rejection episodes after successful transplantation. The aim of the current study was to investigate whether graft rejection after renal transplantation is associated with patient-reported IS medication non-adherence and IS trough level variables (IS trough level variability and percentage of sub-therapeutic IS trough levels). Patient-reported non-adherence, IS trough level variability, percentage of sub-therapeutic IS trough levels, and acute biopsy-proven late allograft rejections were assessed in 267 adult renal transplant recipients who were ≥12 months post-transplantation. The rate of rejection was 13.5%. IS trough level variability, percentage of sub-therapeutic IS trough levels as well as patient-reported non-adherence were all significantly and positively associated with rejection, but not with each other. Logistic regression analyses revealed that only the percentage of sub-therapeutic IS trough levels and age at transplantation remained significantly associated with rejection. Particularly, the percentage of sub-therapeutic IS trough levels is associated with acute rejections after kidney transplantation whereas IS trough level variability and patient-reported non-adherence seem to be of subordinate importance. Patient-reported non-adherence and IS trough level variables were not correlated; thus, non-adherence should always be measured in a multi-methodological approach. Further research concerning the best combination of non-adherence measures is needed.

Archaeological Evaluation of the Paris Road Site (16 or 41), Orleans Parish, Louisiana.

DTIC Science & Technology

1984-03-01

Little Woods middens (16 OR 1 to 16 OR 5) " located northwest of the study area. Unfortunately, the records and most of the artifacts have been lost (Ford...the Little Woods and Big Oak Island (16 OR 6) sites in Orleans Parish led to -’. a definition of Tchefuncte material culture. Shenkel’s 1972 to 1974...the Little Woods Middens (16 OR 1-5) situated along the south shore of Lake Pontchartrain. Unfortunately, Czajkowski’s notes and artifact records

Experimental feeding of DDE and PCB to female big brown bats (Eptesicus fuscus). [1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, D.R. Jr.; Prouty, R.M.

Twenty-two female big brown bats (Eptesicus fuscus) were collected in a house attic in Montgomery County, Maryland. Seventeen were fed mealworms (Tenebrio molitor larvae) that contained 166 ppM DDE; the other five were fed uncontaminated mealworms. After 54 days of feeding, six dosed bats were frozen and the remaining 16 were starved to death. In a second experiment, 21 female big brown bats were collected in a house attic in Prince Georges County, Maryland. Sixteen were fed mealworms that contained 9.4 ppM Aroclor 1254 (PCB). After 37 days, two bats had died, four dosed bats were frozen, and the remainingmore » 15 were starved to death. Starvation caused mobilization of stored residues. After the feeding periods, average weights of all four groups (DDE-dosed, DDE control, PCB-dosed, PCB control) had increased. However, weights of DDE-dosed bats had increased significantly more than those of their controls, whereas weights of PCB-dosed bats had increased significantly less than those of their controls. During starvation, PCB-dosed bats lost weight significantly more slowly than controls. Because PCB levels in dosed bats resembled levels found in some free-living big brown bats, PCBs may be slowing metabolic rates of some free-living bats. It is not known how various common organochlorine residues may affect metabolism in hibernating bats.« less

SHARAD Radar investigations into the initiation of spiral troughs on Planum Boreum, Mars

NASA Astrophysics Data System (ADS)

Smith, I. B.; Holt, J. W.

2010-12-01

Recent evidence demonstrates that the prominent spiral troughs of the North Polar Layered Deposits (NPLD) on Mars are not young features, having persisted and evolved during accumulation of more than 500 meters of ice [Smith and Holt, Nature, 2010]. Because of the rich stratigraphy in the NPLD, determining the processes controlling trough formation and evolution is an important step in understanding the history of ice and climate on Mars. Multiple periods of trough initiation are observed in radar data collected by the Shallow Radar (SHARAD) instrument on Mars Reconnaissance Orbiter; however, the mechanism behind trough initiation is still a mystery. Discrete radar reflectors can be associated with the onset of spiral troughs because of their stratigraphic relationships: below the reflectors the troughs do not exist, and above the troughs begin to take shape. To address the question of trough formation we have mapped these reflectors, which are assumed to represent isochrones, in more than 400 SHARAD observations throughout the NPLD. Taken together these represent the surfaces where troughs initiated, i.e. surfaces that lie directly below the first appearance of troughs. When observation geometries are favorable, we find that the onset of each trough rests on a change in slope usually at the base of a buried erosional scarp. The underlying layers end abruptly at the scarps rather than diminish or pinch out with distance, suggesting that the NPLD underwent cap-wide erosion predating trough formation. This surface morphology provides the initial conditions needed to form troughs from the combination of deposition and katabatic winds affected by surface slope. Radar observations indicate that the troughs initiated and evolved with approximately the same wavelength as can be measured today. Thus proposed hypotheses of small bedforms growing into larger wavelength structures is not supported. Locally, the unconformable contact between younger, trough-related material and older eroded surfaces is exposed at the surface. Neither the younger nor older exposed layers show small-scale bedforms, supporting this conclusion. At least two initiation surfaces can be observed in the radar data within the uppermost 500 m of the NPLD. Alternating periods of erosion and deposition are predicted to result from large changes in obliquity and insolation at the Martian north pole [Laskar et al., Nature, 2004], suggesting that trough initiation may be related to orbital forcing.

Designer Troughs

NASA Image and Video Library

2006-06-11

This MOC image shows a wide, flat-floored trough flanked by several smaller, branching troughs in the Olympica Fossae region of Mars. Dark- and intermediate-toned slope streaks -- created by dry avalanches of dust -- occur on the trough walls

The origin and peculiarities of the nigerian benue trough: Another look from recent gravity data obtained from the middle benue

NASA Astrophysics Data System (ADS)

Ajayi, C. O.; Ajakaiye, D. E.

1981-12-01

The origin of the Benue trough has been a controversial subject. Previous workers in the area have evolved several theories ranging from a rift, with or without plate tectonic concepts (King, 1950; Wright, 1968, 1970; Burke et al., 1970; Grant, 1971; Olade, 1975) to a geosyncline (Lees, 1952) and a combination of both (Cratchley and Jones, 1965; Offodile, 1976) to explain the origin of the trough. One of the aims of the gravity survey, carried out in the middle Benue and discussed in this paper, was to attempt to resolve some of the problems associated with the origin of the trough as proposed by previous workers and in so doing to explain the geological peculiarities associated with the trough. Interpretations of the gravity data along two north—south profiles in the survey area indicated the existence of a rift, of normal width (about 40 km) buried under the Cretaceous cover and located between the central axis (ridge) of the trough and the northern boundary of the trough. The gravity minimum which occurs south of the central axis of the trough, was also ascribed to another rift. Thus the Benue trough is considered to consist of two parallel rifts separated by the axial ridge which partly explains the abnormal width of the trough. The interpreted models also indicate a low-angle thrust fault, with a small displacement, which may be related to the folding of the sediments in the trough and also to the asymmetry of the trough. Furthermore, the gravity data suggest that oceanic crust might not have reached the ground surface in the Benue trough, as in the Red Sea, before rifting ceased.

Modeling canopy-level productivity: is the "big-leaf" simplification acceptable?

NASA Astrophysics Data System (ADS)

Sprintsin, M.; Chen, J. M.

2009-05-01

The "big-leaf" approach to calculating the carbon balance of plant canopies assumes that canopy carbon fluxes have the same relative responses to the environment as any single unshaded leaf in the upper canopy. Widely used light use efficiency models are essentially simplified versions of the big-leaf model. Despite its wide acceptance, subsequent developments in the modeling of leaf photosynthesis and measurements of canopy physiology have brought into question the assumptions behind this approach showing that big leaf approximation is inadequate for simulating canopy photosynthesis because of the additional leaf internal control on carbon assimilation and because of the non-linear response of photosynthesis on leaf nitrogen and absorbed light, and changes in leaf microenvironment with canopy depth. To avoid this problem a sunlit/shaded leaf separation approach, within which the vegetation is treated as two big leaves under different illumination conditions, is gradually replacing the "big-leaf" strategy, for applications at local and regional scales. Such separation is now widely accepted as a more accurate and physiologically based approach for modeling canopy photosynthesis. Here we compare both strategies for Gross Primary Production (GPP) modeling using the Boreal Ecosystem Productivity Simulator (BEPS) at local (tower footprint) scale for different land cover types spread over North America: two broadleaf forests (Harvard, Massachusetts and Missouri Ozark, Missouri); two coniferous forests (Howland, Maine and Old Black Spruce, Saskatchewan); Lost Creek shrubland site (Wisconsin) and Mer Bleue petland (Ontario). BEPS calculates carbon fixation by scaling Farquhar's leaf biochemical model up to canopy level with stomatal conductance estimated by a modified version of the Ball-Woodrow-Berry model. The "big-leaf" approach was parameterized using derived leaf level parameters scaled up to canopy level by means of Leaf Area Index. The influence of sunlit/shaded leaf separation on GPP prediction was evaluated accounting for the degree of the deviation of 3-dimensional leaf spatial distribution from the random case. More specifically, we compared and evaluated the behavior of both models showing the advantages of sunlit/shaded leaf separation strategy over a simplified big-leaf approach. Keywords: canopy photosynthesis, leaf area index, clumping index, remote sensing.

Monitoring of seafloor crustal deformation using GPS/Acoustic technique along the Nankai Trough, Japan

NASA Astrophysics Data System (ADS)

Yasuda, K.; Tadokoro, K.; Ikuta, R.; Watanabe, T.; Fujii, C.; Matsuhiro, K.; Sayanagi, K.

2014-12-01

Seafloor crustal deformation is crucial for estimating the interplate locking at the shallow subduction zone and has been carried out at subduction margins in Japan, e.g., Japan Trench and Nankai Trough [Sato et al., 2011; Tadokoro et al., 2012]. Iinuma et al. [2012] derived slip distributions during the 2011 Tohoku-Oki earthquake using GPS/Acoustic data and on-land GPS data. The result showed that maximum slip is more than 85 m near the trench axis. The focal area along the Nankai trough extended to the trough axis affected this earthquake by cabinet office, government of Japan. 　We monitored seafloor crustal deformation along the Nankai trough, Japan. Observation regions are at the eastern end of Nankai trough (named Suruga trough) and at the central Nankai trough. We established and monitored by two sites across the trough at each region. In the Suruga trough region, we repeatedly observed from 2005 to 2013. We observed 13 and 14 times at a foot wall side (SNE) and at a hanging wall side (SNW), respectively. We estimated the displacement velocities with relative to the Amurian plate from the result of repeated observation. The estimated displacement velocity vectors at SNE and SNW are 42±8 mm/y to N94±3˚W direction and 39±11 mm/y to N84±9˚W direction, respectively. The directions are the same as those measured at the on-land GPS stations. The magnitudes of velocity vector indicate significant shortening by approximately 4 mm/y between SNW and on-land GPS stations at hanging wall side of the Suruga Trough. This result shows that the plate interface at the northernmost Suruga trough is strongly locked. In the central Nankai trough region, we established new two stations across the central Nankai trough (Both stations are about 15km distance from trough) and observed only three times, August 2013, January 2014, and June 2014. We report the results of monitoring performed in this year.

Lithologic and hydraulic controls on network-scale variations in sediment yield: Big Wood and North Fork Big Lost Rivers, Idaho

NASA Astrophysics Data System (ADS)

Mueller, E. R.; Pitlick, J.; Smith, M. E.

2008-12-01

Channel morphology and sediment textures in streams and rivers are a product of the flux of sediment and water conveyed to channel networks. Differences in sediment supply between watersheds should thus be reflected by differences in channel and bed-material properties. In order to address this directly, field measurements of channel morphology, substrate lithology, and bed sediment textures were made at 35 sites distributed evenly across two adjacent watersheds in south-central Idaho, the Big Wood River (BW) and N. Fork Big Lost River (NBL). Measurements of sediment transport indicate a five-fold difference in sediment yields between these basins, despite their geographic proximity. Three dominant lithologic modes (an intrusive and extrusive volcanic suite and a sedimentary suite) exist in different proportions between these basins. The spatial distribution of lithologies exhibits a first-order control on the variation in sediment supply, bed sediment textures, and size distribution of the bed load at the basin outlet. Here we document the coupled hydraulic and sedimentologic structuring of these stream channel networks to differences in sediment supply. The results show that width and depth are remarkably similar between the two basins across a range in channel gradient and drainage area, with the primary difference being decreased bed armoring in the NBL. As a result, dimensionless shear stress (τ*) increases downstream in the NBL with an average value of 0.073, despite declining slope. The opposite is true in the BW where τ* averages 0.048. Lithologic characterization of the substrate indicates that much of the discrepancy in bed armoring can be attributed to an increasing downstream supply of resistant intrusive granitic rocks to the BW, whereas the NBL is dominated by erodible extrusive volcanic and sedimentary rocks. A simple modeling approach using an excess shear stress-based bed load transport equation and observed channel geometry shows that subtle changes in sediment texture can reproduce the marked difference in sediment yield between basins. This suggests that in gravel-bed streams the flux of sediment through the channel network is governed as much by textural changes as by morphological changes, and that these textural changes are tightly coupled to source area lithology.

Are Vancomycin Trough Concentrations of 15 to 20 mg/L Associated With Increased Attainment of an AUC/MIC ≥ 400 in Patients With Presumed MRSA Infection?

PubMed

Hale, Cory M; Seabury, Robert W; Steele, Jeffrey M; Darko, William; Miller, Christopher D

2017-06-01

To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ≥400. A retrospective analysis was conducted among vancomycin-treated adult patients with a positive methicillin-resistant Staphylococcus aureus (MRSA) culture. Attainment of a calculated AUC/MIC ≥400 was compared between patients with troughs in the reference range of 15 to 20 mg/L and those with troughs in the following ranges: <10, 10 to 14.9, and >20 mg/L. Nephrotoxicity was assessed as a secondary outcome based on corrected average vancomycin troughs over 10 days of treatment. Overall, 226 patients were reviewed and 100 included. Relative to troughs ≥10, patients with vancomycin troughs <10 mg/L were 73% less likely to attain an AUC/MIC ≥400 (odds ratio [OR] 0.27, 95% confidence interval [CI]: 0.01-0.75). No difference was found in the attainment of an AUC/MIC ≥400 in patients with troughs of 10 to 14.9 mg/L and >20 mg/L when compared to patients with troughs of 15 to 20 mg/L. The mean corrected average vancomycin trough was higher in patients developing nephrotoxicity compared to those who did not (19.5 vs 14.5 mg/L, P < .001). Achieving vancomycin serum trough concentrations of 15 to 20 mg/L did not result in an increased attainment of the AUC/MIC target relative to troughs of 10 to 14.9 mg/L but may increase nephrotoxicity risk.

Safety and tolerability of deferasirox in pediatric hematopoietic stem cell transplant recipients: one facility's five years' experience of chelation treatment.

PubMed

Maximova, Natalia; Gregori, Massimo; Simeone, Roberto; Sonzogni, Aurelio; Boz, Giulia; Fucile, Carmen; Marini, Valeria; Martelli, Antonietta; Mattioli, Francesca

2017-09-08

42 pediatric patients with iron overload, who underwent liver biopsy and DFX treatment after hematopoietic stem cell transplantation were included in the study group. The patients were divided into two groups diversified according to deferasirox trough plasma concentrations (DFX C trough ) with cut-off equal to10 mcg/mL. The average dose of DFX was 25.9 mg/kg in the DFX C trough < 10 mcg/mL group versus 19.2 mg/kg in the DFX C trough > 10 mcg/mL group ( p =0,0003). The mean duration of DFX treatment was 135.7 days in the DFX C trough < 10 mcg/mL group versus 41.8 days in the DFX C trough > 10 mcg/mL group ( p <0.0001). The mean tissue iron concentration in the DFX C trough < 10 mcg/mL group was 261.9 μmol/g versus 133.4 μmol/g in the DFX C trough > 10 mcg/mL group ( p < 0.0001). 21 patients (100%) in the DFX C trough > 10 mcg/mL group had ductopenia which was complete in 47.6% of them and severe in 52.4%. All patients with particularly high C trough (> 25 mcg/mL) were found to have total ductopenia. 90.5% of all deferasirox-related adverse events and 100% of major adverse events occurred in the DFX C trough > 10 mcg/mL group. In the DFX C trough < 10 mcg/mL group only one patient interrupted chelation therapy versus 16 (84.2%) patients in the DFX C trough > 10 mcg/mL group. We would recommend a close monitoring in pediatric hematopoietic transplant recipients subjected to deferasirox-based therapy because we have observed a high incidence of adverse events and discontinuation of chelation treatment.

Tectonic controls of a backarc trough-fill turbidite system: The Pliocene Tamugigawa Formation in the Niigata Shin'etsu inverted rift basin, Northern Fossa Magna, central Japan

NASA Astrophysics Data System (ADS)

Takano, Osamu; Tateishi, Masaaki; Endo, Masataka

2005-05-01

The Pliocene Tamugigawa Formation in the Niigata-Shin'etsu inverted rift basin, Northern Fossa Magna, located in the junction zone of the NE and SW Japan arcs, demonstrates a trough-fill turbidite system, which is topographically controlled in depositional style and shows notable contrasts in depositional architecture from sandy radial-fan-type turbidite systems. The Tamugigawa trough-fill turbidite system shows an elongated morphology parallel to the basin extent and facies associations consisting of trough-fill, lateral-supply and trough-side elements. The trough-fill elements comprise thick-bedded sheet sandstone and sheet-flow turbidite associations, which show sheet-like sedimentation configuration, instead of depositional lobes, without distinct upward fining and coarsening successions. The lateral-supply elements form an intra-trough small fan along a lateral sediment-supply system into the troughs, and consist mainly of coarser-grained distributary-channel fills and sheet sandstones. The trough-side elements consist of slope-mudstone and spillover associations, which were deposited on the structural highs beside the troughs. The Tamugigawa trough-fill turbidites were deposited through three phases: (a) initial ponding stage with thick, sheet sandstones provided by the lateral-supply system, (b) main filling stage with sheet-flow turbidites provided by the longitudinal supply system, and (c) filled-up stage characterized by minor-scale channel-levee systems. Basin-wide tectono-sedimentary studies reveal that the trough-fill turbidites were characteristically formed during the compressional-stress-field stage related to basin inversion. The compressional stress induced basin-floor syndepositional folding and coarse clastic supply from the uplifted provenance, resulting in topographically restricted turbidite deposition within the troughs. In contrast, turbidites of the post-rift stage, prior to basin inversion, show no topographical control because of the simple and wide rift-basin topography, relative to the amount of sediment supply. It is concluded that the trough-fill turbidites of the Niigata-Shin'etsu basin have been strongly affected by basin tectonics in their depositional architecture and formation phases.

The Effect of Age and Weight on Vancomycin Serum Trough Concentrations in Pediatric Patients

PubMed Central

Madigan, Theresa; Sieve, Ronald M.; Graner, Kevin K.; Banerjee, Ritu

2013-01-01

Background Vancomycin treatment failure has been associated with low serum vancomycin trough concentrations, prompting recommendations to increase the daily doses in adults and children. Despite more aggressive vancomycin dosing, there continues to be significant variability in vancomycin trough concentrations in pediatric patients. Methods To determine if vancomycin trough concentrations in pediatric patients differ by age and weight, we reviewed records of hospitalized patients who received vancomycin between 2008 and 2012. Patients were divided into groups that received vancomycin 40 mg/kg/day (2008 to 2009) or 60 mg/kg/day (2010 to 2012). Vancomycin trough concentrations were compared between groups and within the 60-mg/kg/day group, stratified by patient age and weight. Results After increasing the vancomycin dose from 40 mg/kg/day to 60 mg/kg/day, initial trough concentrations increased significantly in patients younger than 2 and greater than 6 years of age, but not in patients between the ages of 2 and 5 years. In the 60-mg/kg/day group, only 16.7% of patients between 2 and 5 years of age had initial trough concentrations in the therapeutic range (10 mcg/mL to 20 mcg/mL). Initial trough concentrations were therapeutic in a greater proportion of patients ages 6 years to 12 years (38.7%) and 13 years to 18 years (63.0%). Patients between the ages of 13 and 18 had the highest proportion of supratherapeutic initial vancomycin trough concentrations (14.8%). Patients weighing > 50 kg had significantly higher trough concentrations than patients ≤ 50 kg (17.1 mcg/mL vs. 9.3 mcg/mL; p<0.001). Conclusion Although increasing the vancomycin dose from 40 mg/kg/day to 60 mg/kg/day led to a significant increase in vancomycin trough concentrations, a large proportion of patients receiving 60 mg/kg/day of vancomycin had trough concentrations outside of the therapeutic range. Specifically, patients younger than 6 years tend to have low trough concentrations, while adolescents and children > 50 kg are more likely to have elevated trough concentrations. Vancomycin dosing strategies in pediatric patients should consider age and weight as well as renal function and indication. PMID:23864541

Cracked Mars

NASA Technical Reports Server (NTRS)

2006-01-01

25 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows v-shaped troughs in the Hephaestus Fossae region of Mars. Light-toned, windblown ripples reside in the very lowest parts of the troughs, as well as on the cratered upland outside the troughs. Boulders and other types of debris, which were derived from the layered rock exposed near the top of the troughs, are seen resting on the trough floors and perched on the sloping trough walls.

Location near: 21.1oN, 236.7oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Spring

Solar photovoltaic reflective trough collection structure

DOEpatents

Anderson, Benjamin J.; Sweatt, William C.; Okandan, Murat; Nielson, Gregory N.

2015-11-19

A photovoltaic (PV) solar concentration structure having at least two troughs encapsulated in a rectangular parallelepiped optical plastic structure, with the troughs filled with an optical plastic material, the troughs each having a reflective internal surface and approximately parabolic geometry, and the troughs each including photovoltaic cells situated so that light impinging on the optical plastic material will be concentrated onto the photovoltaic cells. Multiple structures can be connected to provide a solar photovoltaic collection system that provides portable, efficient, low-cost electrical power.

Concentrating Solar Power Projects - Gansu Akesai 50MW Molten Salt Trough

Science.gov Websites

project | Concentrating Solar Power | NREL Gansu Akesai 50MW Molten Salt Trough project Status . Technology: Parabolic trough Turbine Capacity: Net: 50.0 MW Gross: 50.0 MW Status: Under development Do you have more information, corrections, or comments? Background Technology: Parabolic trough Status: Under

Paleocene Pacific Plate reorganization mirrored in formation of the Suvarov Trough, Manihiki Plateau

NASA Astrophysics Data System (ADS)

Pietsch, Ricarda; Uenzelmann-Neben, Gabriele

2016-10-01

The Suvarov Trough is a graben structure that deviates from the Danger Islands Troughs within the Manihiki Plateau, a Large Igneous Province (LIP) located in the Central Pacific. New high-resolution seismic reflection data provide evidence that the graben formed in two phases during the Paleocene (65-45 Ma). In a first phase extension occurred in southwestward direction, pulling apart the northern part of the Suvarov Trough and a parallel trending unnamed trough. In a second phase a change of extensional force direction occurred from southwest to west-northwest, forming the southern part of the Suvarov Trough that extends onto the High Plateau. The formation of the Suvarov Trough is accompanied by a series of normal fault systems that apparently formed simultaneously. Comparing the seismic results to existing Pacific paleo strain reconstructions, the timing of increased strain and local deformation direction fits well to our findings. We thus suggest that the multiple strike directions of the Suvarov Trough represent an extensional structure that was caused by the major, stepwise Pacific Plate reorganization during the Paleocene.

Single-shot antithymocyte globuline and daclizumab induction in simultaneous pancreas and kidney transplant recipient: three-year results.

PubMed

Schulz, T; Flecken, M; Kapischke, M; Busing, M

2005-05-01

Since 1996, preoperative single-shot dose antithymocyte globuline (ATG) with prednisolone (PRD), mycophenolate mofetile (MMF), and tacrolimus (TAC) is the favorite induction therapy in our center. In a series of 25 first simultaneous pancreas and kidney transplant (SPK) recipients, 5 doses of daclizumab were administered in addition to standard induction. Here we present our 3-year experience. Immunosuppression was started prior to reperfusion consisting of daclizumab (1 mg/kg body weight [bw]), ATG (4-6 mg/kg bw) and 250 mg PRD. After surgery, PRD was reduced gradually, TAC trough levels were between 8-15 ng/mL, MMF was given twice daily (2-3 g/d) as well as 4 further doses dacilzumab every 14 days. After 3 years, patient, pancreas, and kidney graft survival rates are 100%, 84%, and 92%, respectively. Four pancreas grafts were lost (chronic allograft dysfunction, n = 2; recurrent abdominal infection, n = 1; acute rejection [AR] without treatment, n = 1). Both patients suffering from severe infection and untreated AR lost their kidney graft too. During the first 3 months after SPK, 3 AR episodes were observed in 2 patients (8%). After a 3-year period, 8 AR episodes occurred in 7 recipients (28%). AR was treated using PRD (n = 5) or ATG (n = 1). In 1 case, immunosuppression was switched from TAC to sirolimus successfully. Overall, 8 AR episodes occurred in 7 patients (28%) during the first 3 years after SPK. One severe infection led to graft lost 13 months after SPK. In this series, the combination of ATG and daclizumab prevented AR episodes, successfully providing considerable 3-year survival rates.

Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption.

PubMed

Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y

2017-05-01

Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

Aeolian sand transport over complex intertidal bar-trough beach topography

NASA Astrophysics Data System (ADS)

Anthony, Edward J.; Ruz, Marie-Hélène; Vanhée, Stéphane

2009-04-01

Aeolian sand transport on macrotidal beaches with complex intertidal bar-trough topography (ridge-and-runnel beaches) was assessed from experiments in northern France that involved measurements of wind speed, saltation, surface moisture contents, and rates of sand trapping across surveyed portions of the upper beach profile. Beaches exhibiting intertidal bars and troughs are much more complex, topographically, than simple reflective or dissipative beaches. Furthermore, the intertidal bar-trough morphology commonly exhibits strong cross-shore variations in the moisture contents of the beach surface and in patterns of bedform development. The results of four 30-minute experiments, conducted along topographically surveyed portions of the upper beach-dune toe profile, show that troughs act as extremely efficient sand interceptors, because of their permanently saturated state, which also inhibits sand mobilisation. Troughs, thus, limit or segment the dry fetch during conditions of intermittent saltation. Flow lines, inferred from the wind profiles, suggest that complex interactions at the boundary layer are generated by the bar-trough topography. Troughs systematically appear to be characterised by air expansion, while bar faces generate ramp wind acceleration for onshore winds, and sometimes immediate downwind deceleration for offshore winds. These effects may also contribute to cross-shore variations in the rates of sand trapping. Finally, a simple conceptual model of effective fetch development, integrating the effects of the spring-neap tidal range and of gross bar-trough morphological variability over time, is proposed for bar-trough beaches. The model highlights the key theme of fetch segmentation induced by cross-shore differentiation in the moisture contents of the beach surface hinged on the complex topography of multiple bars and troughs.

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing?

PubMed Central

Youn, Gilmer; Jones, Brenda; Jelliffe, Roger W.; Drusano, George L.; Rodvold, Keith A.; Lodise, Thomas P.

2014-01-01

The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC). We assembled richly sampled vancomycin pharmacokinetic data from three studies comprising 47 adults with various levels of renal function. With Pmetrics, the nonparametric population modeling package for R, we compared AUCs estimated from models derived from trough-only and peak-trough depleted versions of the full data set and characterized the relationship between the vancomycin trough concentration and AUC. The trough-only and peak-trough depleted data sets underestimated the true AUCs compared to the full model by a mean (95% confidence interval) of 23% (11 to 33%; P = 0.0001) and 14% (7 to 19%; P < 0.0001), respectively. In contrast, using the full model as a Bayesian prior with trough-only data allowed 97% (93 to 102%; P = 0.23) accurate AUC estimation. On the basis of 5,000 profiles simulated from the full model, among adults with normal renal function and a therapeutic AUC of ≥400 mg · h/liter for an organism for which the vancomycin MIC is 1 mg/liter, approximately 60% are expected to have a trough concentration below the suggested minimum target of 15 mg/liter for serious infections, which could result in needlessly increased doses and a risk of toxicity. Our data indicate that adjustment of vancomycin doses on the basis of trough concentrations without a Bayesian tool results in poor achievement of maximally safe and effective drug exposures in plasma and that many adults can have an adequate vancomycin AUC with a trough concentration of <15 mg/liter. PMID:24165176

Evaluation of the trough-type rain gage

Treesearch

Irvin C. Reigner

1964-01-01

Although infrequently used, the trough-type rain gage has been described as aerodynamically the most efficient of gages (Hayes and Kittredge 1949). This applies only to the commercial semicircular eave-gutter type of trough and not to troughs rectangular in cross-section. The latter, as well as the upright cylindrical type of gage, produces greater disturbances in the...

Method and apparatus for measuring shear modulus and viscosity of a monomolecular film

DOEpatents

Abraham, B.M.; Miyano, K.; Ketterson, J.B.

1983-10-18

Apparatus for measuring the shear modulus of a monomolecular film comprises a circular trough having inwardly sloping sides containing a liquid for supporting the monolayer on the surface thereof; a circular rotor suspended above the trough such that the lower surface of the rotor contacts the surface of the liquid, positioned such that the axis of the rotor is concentric with the axis of the trough and freely rotable about its axis; means for hydrostatically compressing the monolayer in the annular region formed between the rotor and the sides of the trough; and means for rotating the trough about its axis. Preferably, hydrostatic compression of the monolayer is achieved by removing liquid from the bottom of the trough (decreasing the surface area) while raising the trough vertically along its axis to maintain the monolayer at a constant elevation (and maintain rotor contact). In order to measure viscosity, a means for rotating the rotor about its axis is added to the apparatus.

Method and apparatus for measuring shear modulus and viscosity of a monomolecular film

DOEpatents

Abraham, Bernard M.; Miyano, Kenjiro; Ketterson, John B.

1985-01-01

Instrument for measuring the shear modulus of a monomolecular film comprises a circular trough having inwardly sloping sides containing a liquid for supporting the monolayer on the surface thereof; a circular rotor suspended above the trough such that the lower surface of the rotor contacts the surface of the liquid, positioned such that the axis of the rotor is concentric with the axis of the trough and freely rotable about its axis; apparatus for hydrostatically compressing the monolayer in the annular region formed between the rotor and the sides of the trough; and apparatus for rotating the trough about its axis. Preferably, hydrostatic compression of the monolayer is achieved by removing liquid from the bottom of the trough (decreasing the surface area) while raising the trough vertically along its axis to maintain the monolayer at a constant elevation (and maintain rotor contact). In order to measure viscosity, a apparatus for rotating the rotor about its axis is added to the apparatus.

Concentrating Solar Power Projects in China | Concentrating Solar Power |

Science.gov Websites

Delingha 50MW Thermal Oil Parabolic Trough project Gansu Akesai 50MW Molten Salt Trough project Golden Tower 100MW Molten Salt project Golmud Gulang 100MW Thermal Oil Parabolic Trough project Hami 50 MW CSP Yumen 50MW Thermal Oil Trough project Shangyi 50MW DSG Tower CSP project SunCan Dunhuang 10 MW Phase I

The Relationship Between Vancomycin Trough Concentrations and AUC/MIC Ratios in Pediatric Patients: A Qualitative Systematic Review.

PubMed

Tkachuk, Stacey; Collins, Kyle; Ensom, Mary H H

2018-04-01

In adults, the area under the concentration-time curve (AUC) divided by the minimum inhibitory concentration (MIC) is associated with better clinical and bacteriological response to vancomycin in patients with methicillin-resistant Staphylococcus aureus who achieve target AUC/MIC ≥ 400. This target is often extrapolated to pediatric patients despite the lack of similar evidence. The impracticalities of calculating the AUC in practice means vancomycin trough concentrations are used to predict the AUC/MIC. This review aimed to determine the relationship between vancomycin trough concentrations and AUC/MIC in pediatric patients. We searched the MEDLINE and Embase databases, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials using the medical subject heading (MeSH) terms vancomycin and AUC and pediatric* or paediatric*. Articles were included if they were published in English and reported a relationship between vancomycin trough concentrations and AUC/MIC. Of 122 articles retrieved, 11 met the inclusion criteria. One trial reported a relationship between vancomycin trough concentrations, AUC/MIC, and clinical outcomes but was likely underpowered. Five studies found troughs 6-10 mg/l were sufficient to attain an AUC/MIC > 400 in most general hospitalized pediatric patients. One study in patients undergoing cardiothoracic surgery found a trough of 18.4 mg/l achieved an AUC/MIC > 400. Two oncology studies reported troughs ≥ 15 mg/l likely attained an AUC/MIC ≥ 400. In critical care patients: one study found a trough of 9 mg/l did not attain the AUC/MIC target; another found 7 mg/l corresponded to an AUC/MIC of 400. Potential vancomycin targets varied based on the population studied but, for general hospitalized pediatric patients, troughs of 6-10 mg/l are likely sufficient to achieve AUC/MIC ≥ 400. For MIC ≥ 2 mg/l, higher troughs are likely necessary to achieve an AUC/MIC ≥ 400. More research is needed to determine the relationships between vancomycin trough concentrations, AUC/MIC, and clinical outcomes.

Vancomycin AUC/MIC and Corresponding Troughs in a Pediatric Population

PubMed Central

Lardieri, Allison B.; Heil, Emily L.; Morgan, Jill A.

2017-01-01

OBJECTIVES Adult guidelines suggest an area under the curve/minimum inhibitory concentration (AUC/MIC) > 400 corresponds to a vancomycin trough serum concentration of 15 to 20 mg/L for methicillin-resistant Staphylococcus aureus infections, but obtaining these troughs in children are difficult. The primary objective of this study was to assess the likelihood that 15 mg/kg of vancomycin every 6 hours in a child achieves an AUC/MIC > 400. METHODS This retrospective chart review included pediatric patients >2 months to <18 years with a positive S aureus blood culture and documented MIC who received at least two doses of vancomycin with corresponding trough. Patients were divided into two groups: group 1 initially receiving ≥15 mg/kg every 6 hours, and group 2 initially receiving any other dosing ranges or intervals. AUCs were calculated four times using three pharmacokinetic methods. RESULTS A total of 36 patients with 99 vancomycin trough serum concentrations were assessed. Baseline characteristics were similar between groups. For troughs in group 1 (n = 55), the probability of achieving an AUC/MIC > 400 ranged from 16.4% to 90.9% with a median trough concentration of 11.4 mg/L, while in group 2 (n = 44) the probability of achieving AUC/MIC > 400 ranged from 15.9% to 54.5% with mean trough concentration of 9.2 mg/L. The AUC/MICs were not similar between the different pharmacokinetic methods used; however, a trapezoidal equation (Method A) yielded the highest correlation coefficient (r2 = 0.59). When dosing every 6 hours, an AUC/MIC of 400 correlated to a trough serum concentration of 11 mg/L. CONCLUSIONS The probability of achieving an AUC/MIC > 400 using only a trough serum concentration and an MIC with patients receiving 15 mg/kg every 6 hours is variable based on the method used to calculate the AUC. An AUC/MIC of 400 in children correlated to a trough concentration of 11 mg/L using a trapezoidal Method to calculate AUC. PMID:28337080

Vancomycin AUC/MIC and Corresponding Troughs in a Pediatric Population.

PubMed

Kishk, Omayma A; Lardieri, Allison B; Heil, Emily L; Morgan, Jill A

2017-01-01

Adult guidelines suggest an area under the curve/minimum inhibitory concentration (AUC/MIC) > 400 corresponds to a vancomycin trough serum concentration of 15 to 20 mg/L for methicillin-resistant Staphylococcus aureus infections, but obtaining these troughs in children are difficult. The primary objective of this study was to assess the likelihood that 15 mg/kg of vancomycin every 6 hours in a child achieves an AUC/MIC > 400. This retrospective chart review included pediatric patients >2 months to <18 years with a positive S aureus blood culture and documented MIC who received at least two doses of vancomycin with corresponding trough. Patients were divided into two groups: group 1 initially receiving ≥15 mg/kg every 6 hours, and group 2 initially receiving any other dosing ranges or intervals. AUCs were calculated four times using three pharmacokinetic methods. A total of 36 patients with 99 vancomycin trough serum concentrations were assessed. Baseline characteristics were similar between groups. For troughs in group 1 (n = 55), the probability of achieving an AUC/MIC > 400 ranged from 16.4% to 90.9% with a median trough concentration of 11.4 mg/L, while in group 2 (n = 44) the probability of achieving AUC/MIC > 400 ranged from 15.9% to 54.5% with mean trough concentration of 9.2 mg/L. The AUC/MICs were not similar between the different pharmacokinetic methods used; however, a trapezoidal equation (Method A) yielded the highest correlation coefficient (r 2 = 0.59). When dosing every 6 hours, an AUC/MIC of 400 correlated to a trough serum concentration of 11 mg/L. The probability of achieving an AUC/MIC > 400 using only a trough serum concentration and an MIC with patients receiving 15 mg/kg every 6 hours is variable based on the method used to calculate the AUC. An AUC/MIC of 400 in children correlated to a trough concentration of 11 mg/L using a trapezoidal Method to calculate AUC.

Origin and late quaternary tectonism of a western Canadian continental shelf trough

NASA Astrophysics Data System (ADS)

Moslow, Thomas F.; Luternauer, John L.; Rohr, Kristin

1991-08-01

Analyses of high resolution and multi-channel seismic profiles from the central continental shelf of western Canada ascribe a late Quaternary glacial origin to large-scale troughs. Along the margins of Moresby Trough, one of three large-scale cross-shelf bathymetric depressions in Queen Charlotte Sound, seismic profiles within Quaternary sediments show a divergence of reflectors, thickening and folding of seismic units, and concavity of reflectors suggestive of drag. Compactional subsidence, growth faulting, and compaction faulting are also observed. Fault traces commonly terminate below the seabed. Deformation of Quaternary sediments due to faulting is plastic in nature and maximum offset of reflectors is 2.5 m. The observed Quaternary deformation appears to be a product of rapid deposition, loading and subsidence of late Quaternary sediment, which is unrelated to seismic activity. In addition, Quaternary faulting was probably activated by post-glacial loading and isostatic rebound of consolidated Tertiary strata along the margins of continental shelf troughs. The presence of mass movement (slump or debris flow) deposits overlying lithified Tertiary strata along the flanks of Moresby Trough provides the only evidence of seismic activity in the study area. The lack of a mud drape over these deposits implies a late Holocene age for the timing of their emplacement. The Quaternary troughs are incised into Tertiary-aged sedimentary fill of the Queen Charlotte basin. Previous workers had interpreted seafloor escarpments paralleling the trough margins to indicate that the location of Moresby Trough was controlled by renewed or continued activity on Tertiary-aged faults. A multi-channel seismic line across Moresby Trough shows that such an escarpment on the seafloor does not correlate to faults either in the Tertiary basin fill or the underlying basement. Tertiary reflectors are continuous underneath Moresby Trough; the seafloor escarpment is an erosional feature and was not created by reactivation of Tertiary structures. Trough erosion and subsequent fill (up to 175 m thick) are entirely of Quaternary age.

Concurrent immunomodulator therapy is associated with higher adalimumab trough levels during scheduled maintenance therapy.

PubMed

Bond, Ashley; Dodd, Susanna; Fisher, Gareth; Skouras, Thomas; Subramanian, Sreedhar

2017-02-01

Combination therapy with infliximab and immunomodulators is superior to monotherapy, resulting in better outcomes and higher trough levels of infliximab. The role of concurrent immunomodulatory therapy on adalimumab trough levels has not been adequately investigated. We evaluated the impact of concomitant immunomodulation on adalimumab trough levels in patients on scheduled maintenance therapy. We conducted a prospective observational, cross-sectional study of all inflammatory bowel disease patients on maintenance therapy who had adalimumab trough levels measured between January 2013 and January 2016. Drug level and anti-drug antibody measurements were performed on sera using a solid phase assay. Pairwise comparison of means was used to compare trough levels in patients with and without concomitant immune modulator therapy. In total, 79 patients were included. Twenty-three patients (29.1%) were on weekly dosing whereas 56 (70.9%) were on alternate weeks. Median adalimumab trough levels were comparable in patients with and without clinical remission (6.8 μg/ml (IQR 5.6-8.1) versus 6.7 μg/ml (IQR 3.9-8.1), respectively. Patients with an elevated faecal calprotectin >250 μg/g had lower adalimumab trough levels (median 6.7, IQR 3.9-8) compared to patients with faecal calprotectin <250 μg/g (median 7.7, IQR 6.1-8.1) though this did not achieve statistical significance (p = .062). Median adalimumab trough levels among patients on concurrent immunomodulators was 7.2 μg/ml (IQR 5.7-8.1) compared to those not on concurrent immunomodulator, 6.1 μg/ml (IQR 2.7-7.7, p = .0297). Adalimumab trough levels were significantly higher in patients on concurrent immunomodulators during maintenance therapy. There was a trend towards a lower adalimumab trough level in patients with elevated calprotectin.

Devonian salt dissolution-collapse breccias flooring the Cretaceous Athabasca oil sands deposit and development of lower McMurray Formation sinkholes, northern Alberta Basin, Western Canada

NASA Astrophysics Data System (ADS)

Broughton, Paul L.

2013-01-01

The sub-Cretaceous paleotopography underlying giant Lower Cretaceous Athabasca oil sands, northern Alberta, has an orthogonal lattice pattern of troughs up to 50 km long and 100 m deep between pairs of cross-cutting lineaments. These structures are interpreted to have been inherited from a similar pattern of dissolution collapse-subsidence troughs in the underlying Middle Devonian salt beds. Removal of more than 100 m of halite salt fragmented the overlying Upper Devonian strata into fault blocks and collapse breccias that subsided into the underlying dissolution troughs. The unusually low 1:2 to 1:3 thickness ratios of halite salts to the overlying strata resulted in the Upper Devonian strata collapse-subsidence into underlying salt dissolution troughs being more cataclysmic during the first phase of salt removal. The second phase of slower but complete salt removal between the earlier troughs resulted in a more gradual subsidence of the overlying strata. This obliterated the earlier pattern of giant cross-cutting dissolution troughs bounded by major lineaments. The collapse breccia fabrics underlying the earlier troughs differ from those from areas between the troughs. Collapse breccias underlying the large troughs often have crushed fabrics distributed in zones that rapidly pinched out between fault blocks. Breccias between troughs developed as giant mosaics of detached carbonate blocks that formed breccia pipe complexes. Multiple sinkholes up to 100 m deep aligned along multi-km linear valley trends that dissected the sub-Cretaceous paleotopography. These sinkhole trends formed orthogonal patterns inherited from underlying lattice of NW-SE and NE-SW salt structured lineaments. These cross-cutting sinkhole trends have a smaller 5 km scale reticulate pattern similar to the giant 50 km scale pattern of collapse-subsidence troughs. Other sinkholes developed as lower McMurray strata sagged when underlying Devonian fault blocks and breccia pipes differentially subsided.

Pc-5 wave power in the plasmasphere and trough: CRRES observations

NASA Astrophysics Data System (ADS)

Hartinger, M.; Moldwin, M.; Angelopoulos, V.; Takahashi, K.; Singer, H. J.; Anderson, R. R.

2009-12-01

The CRRES (Combined Release and Radiation Effects Satellite) mission provides an opportunity to study the distribution of MHD wave power in the inner magnetosphere both inside the high-density plasmasphere and in the low-density trough. We present a statistical survey of Pc-5 wave power using CRRES magnetometer and plasma wave data separated into plasmasphere and trough intervals. Using a database of plasmapause crossings, we examined differences in power spectral density between the plasmasphere and trough regions. We found significant differences between the plasmasphere and trough in the radial profiles of Pc-5 wave power. On average, wave power was higher in the trough, but the difference in power depended on magnetic local time. Our study shows that determining the plasmapause location is important for understanding and modeling the MHD wave environment in the Pc-5 frequency band.

The light ion trough.

NASA Technical Reports Server (NTRS)

Taylor, H. A., Jr.

1972-01-01

A distinct feature of the ion composition results from the OGO-2, 4 and 6 satellites is the light ion trough, wherein the mid-latitude concentrations of H+ and He+ decrease sharply with latitude. In contrast to the 'main trough' in electron density observed primarily as a nightside phenomenon, the light ion trough persists during both day and night. For daytime winter hemisphere conditions and for all seasons during night, the mid-latitude light ion concentration decrease is a pronounced feature. In the dayside summer and equinox hemispheres, the rate of light ion decrease with latitude is comparatively gradual, and the trough boundary is less well defined, particularly for quiet magnetic conditions. In response to magnetic storms, the light ion trough minimum moves equatorward, and deepens, consistent with earlier evidence of the contraction of the plasmasphere in response to storm time enhancements in magnetospheric plasma convection.

The Impact of AUC-Based Monitoring on Pharmacist-Directed Vancomycin Dose Adjustments in Complicated Methicillin-Resistant Staphylococcus aureus Infection.

PubMed

Stoessel, Andrew M; Hale, Cory M; Seabury, Robert W; Miller, Christopher D; Steele, Jeffrey M

2018-01-01

This study aimed to assess the impact of area under the curve (AUC)-based vancomycin monitoring on pharmacist-initiated dose adjustments after transitioning from a trough-only to an AUC-based monitoring method at our institution. A retrospective cohort study of patients treated with vancomycin for complicated methicillin-resistant Staphylococcus aureus (MRSA) infection between November 2013 and December 2016 was conducted. The frequency of pharmacist-initiated dose adjustments was assessed for patients monitored via trough-only and AUC-based approaches for trough ranges: 10 to 14.9 mg/L and 15 to 20 mg/L. Fifty patients were included: 36 in the trough-based monitoring and 14 in the AUC-based-monitoring group. The vancomycin dose was increased in 71.4% of patients when troughs were 10 to 14.9 mg/L when a trough-only approach was used and in only 25% of patients when using AUC estimation ( P = .048). In the AUC group, the dose was increased only when AUC/minimum inhibitory concentration (MIC) <400; unchanged regimens had an estimated AUC/MIC ≥400. The AUC-based monitoring did not significantly increase the frequency of dose reductions when trough concentrations were 15 to 20 mg/L (AUC: 33.3% vs trough: 4.6%; P = .107). The AUC-based monitoring resulted in fewer patients with dose adjustments when trough levels were 10 to 14.9 mg/L. The AUC-based monitoring has the potential to reduce unnecessary vancomycin exposure and warrants further investigation.

Currently used dosage regimens of vancomycin fail to achieve therapeutic levels in approximately 40% of intensive care unit patients.

PubMed

Obara, Vitor Yuzo; Zacas, Carolina Petrus; Carrilho, Claudia Maria Dantas de Maio; Delfino, Vinicius Daher Alvares

2016-01-01

This study aimed to assess whether currently used dosages of vancomycin for treatment of serious gram-positive bacterial infections in intensive care unit patients provided initial therapeutic vancomycin trough levels and to examine possible factors associated with the presence of adequate initial vancomycin trough levels in these patients. A prospective descriptive study with convenience sampling was performed. Nursing note and medical record data were collected from September 2013 to July 2014 for patients who met inclusion criteria. Eighty-three patients were included. Initial vancomycin trough levels were obtained immediately before vancomycin fourth dose. Acute kidney injury was defined as an increase of at least 0.3mg/dL in serum creatinine within 48 hours. Considering vancomycin trough levels recommended for serious gram-positive infection treatment (15 - 20µg/mL), patients were categorized as presenting with low, adequate, and high vancomycin trough levels (35 [42.2%], 18 [21.7%], and 30 [36.1%] patients, respectively). Acute kidney injury patients had significantly greater vancomycin trough levels (p = 0.0055, with significance for a trend, p = 0.0023). Surprisingly, more than 40% of the patients did not reach an effective initial vancomycin trough level. Studies on pharmacokinetic and dosage regimens of vancomycin in intensive care unit patients are necessary to circumvent this high proportion of failures to obtain adequate initial vancomycin trough levels. Vancomycin use without trough serum level monitoring in critically ill patients should be discouraged.

A COLD FLARE WITH DELAYED HEATING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fleishman, Gregory D.; Pal'shin, Valentin D.; Lysenko, Alexandra L.

2016-05-10

Recently, a number of peculiar flares have been reported that demonstrate significant nonthermal particle signatures with low, if any, thermal emission, which implies a close association of the observed emission with the primary energy release/electron acceleration region. This paper presents a flare that appears “cold” at the impulsive phase, while displaying delayed heating later on. Using hard X-ray data from Konus- Wind , microwave observations by SSRT, RSTN, NoRH, and NoRP, context observations, and three-dimensional modeling, we study the energy release, particle acceleration, and transport, and the relationships between the nonthermal and thermal signatures. The flaring process is found tomore » involve the interaction between a small loop and a big loop with the accelerated particles divided roughly equally between them. Precipitation of the electrons from the small loop produced only a weak thermal response because the loop volume was small, while the electrons trapped in the big loop lost most of their energy in the coronal part of the loop, which resulted in coronal plasma heating but no or only weak chromospheric evaporation, and thus unusually weak soft X-ray emission. The energy losses of the fast electrons in the big tenuous loop were slow, which resulted in the observed delay of the plasma heating. We determined that the impulsively accelerated electron population had a beamed angular distribution in the direction of the electric force along the magnetic field of the small loop. The accelerated particle transport in the big loop was primarily mediated by turbulent waves, which is similar to other reported cold flares.« less

Fabrication of trough-shaped solar collectors

DOEpatents

Schertz, William W.

1978-01-01

There is provided a radiant energy concentration and collection device formed of a one-piece thin-walled plastic substrate including a plurality of nonimaging troughs with certain metallized surfaces of the substrate serving as reflective side walls for each trough. The one-piece plastic substrate is provided with a seating surface at the bottom of each trough which conforms to the shape of an energy receiver to be seated therein.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schuett, K.J.; Pawlak, J.P.; Traina, L.

No. 13 Blast Furnace at US Steel`s Gary Works is a 35 tuyere furnace with a 36.5 ft. hearth capable of producing over 9,000 tons of hot metal per day. The current casthouse design was placed in service following the second reline in the fall of 1979. This design anticipated daily production rates averaging 7,500 tons of hot metal per day and provided for removable troughs at two of the three tapholes. At the time, the troughs were rammed with a high alumina/silicon carbide granular ramming material that provided the operators with trough campaign lives between 60,000--70,000 tons of hotmore » metal produced. As refractory technology progressed, low cement/low moisture castables were introduced to the trough systems on No. 13 Blast Furnace. The immediate success of the castables was tempered by emergence of a new unexpected problem. That problem was the thermal expansion of the castable. The paper describes the problems that resulted in the need to modify the trough design, the new design of the trough, and its improvement in iron trough campaign life and reliability.« less

Designing Better Water Troughs: Does Trough Color Influence Dairy Cows' Preference?

PubMed

Lemos Teixeira, Dayane; Hötzel, Maria José; Pinheiro Machado Filho, Luiz Carlos; Cazale, José Daniel; Enríquez-Hidalgo, Daniel

2017-01-01

Eighteen lactating dairy cows were used to elucidate their preference for green, grey, or red troughs. The herd was managed under a rotational grazing system with ad-libitum access to water until 11:30 h. For 9 days, all cows were tested individually following the afternoon milking. Cows drank similar quantities, spent a similar amount of time drinking, and took a similar number of sips from the 3 trough colors (p > .05). In 75% of the tests, cows drank more than 95% of the test period from the same trough. Within this time, the percentage of choices did not differ among colors (33.3% green, 39.0% grey, and 27.7% red). When they chose the red trough, cows spent less time drinking (p ≤ .05) and tended to take fewer sips (p = .07), which could suggest a partial aversion to this color. Suboptimal water trough design may have long-term negative effects on both the production and welfare of dairy cattle; however, the results suggest that color does not play a major role in the drinking behavior of dairy cows.

Paleomagnetic record determined in cores from deep research wells in the Quaternary Santa Clara basin, California

USGS Publications Warehouse

Mankinen, Edward A.; Wentworth, Carl M.

2016-01-01

The Mono Lake (ca. 32 ka), Pringle Falls (ca. 210 ka), and Big Lost (ca. 565 ka) geomagnetic excursions all seem to be represented in the Santa Clara Valley wells. Possible correlations to the Laschamp (ca. 40 ka) and Blake (ca. 110 ka) excursions are also noted. Three additional excursions that have apparently not been previously reported from western North America occur within cycle 6 (between 536 and 433 ka), near the base of cycle 5 (after 433 ka), and near the middle of cycle 2 (before ca. 75 ka).

New sidescan sonar and gravity evidence that the Nova-Canton Trough is a fracture zone

NASA Astrophysics Data System (ADS)

Joseph, Devorah; Taylor, Brian; Shor, Alexander N.

1992-05-01

A 1990 sidescan sonar survey in the eastern region of the Nova-Canton Trough mapped 138°-striking abyssal-hill fabric trending into 70°-striking trough structures. The location and angle of intersection of the abyssal hills with the eastern Nova-Canton Trough effectively disprove a spreading-center origin of this feature. Free-air gravity anomalies derived from satellite altimetry data show continuity, across the Line Islands, of the Nova-Canton Trough with the Clipperton Fracture Zone. The Canton-Clipperton trend is copolar, about a pole at 30°S, 152°W, with other coeval Pacific-Farallon fracture-zone segments, from the Pau to Marquesas fracture zones. This copolarity leads us to postulate a Pacific-Farallon spreading pattern for the magnetic quiet zone region north and east of the Manihiki Plateau, with the Nova-Canton Trough originating as a transform fault in this system.

Topography of Valles Marineris: Implications for erosional and structural history

NASA Technical Reports Server (NTRS)

Lucchitta, B. K.; Isbell, N. K.; Howington-Kraus, A.

1994-01-01

Compilation of a simplified geologic/geomorphic map onto digital terrain models of the Valles Marineris permitted an evaluation of elevations in the vicinity of the troughs and the calculation of depth of troughs below surrounding plateaus, thickness of deposits inside the troughs, volumes of void spaces above geologic/geomorphic units, and volumes of deposits. The central troughs north Ophir, north and central Candor, and north Melas Chasmata lie as much as 11 km below the adjacent plateaus. In Ophir and Candor chasmata, interior layered deposits reach 8 km in elevation. If the deposits are lacustrine and if all troughs were interconnected, lake waters standing 8 km high would have spilled out of Coprates Chasma onto the surrounding plateaus having surface elevations of only 4-5 km. On the other hand, the troughs may not have been interconnected at the time of interior-deposit emplacement; they may have formed isolated ancestral basins. The existence of such basins is supported by independent structural and stratigraphic evidence. The ancestral basins may have eventually merged, perhaps through renewed faulting, to form northern subsidiary troughs in Ophir and Candor Chasmata and the Coprates/north Melas/Ius graben system. The peripheral troughs are only 2-5 km deep, shallower than the central troughs. Chaotic terrain is seen in the peripheral troughs near a common contour level of about 4 km on the adjacent plateaus, which supports the idea of release of water under artesian pressure from confined aquifers. The layered deposits in the peripheral troughs may have formed in isolated depressions that harbored lakes and predated the formation of the deep outflow channels. (If these layered deposits are of volcanic origin, they may have been emplaced beneath ice in the manner of table mountains.) Areal and volumetric computations show that erosion widened the troughs by about one-third and that deposits occupy one-sixth of the interior space. Even though the volume eroded is larger than the volume deposited, topographic and geologic considerations imply that material eroded from trough walls was probably part of the interior layered deposits but not their sole source. Additional material may have come from subterranean piping, from reworking of local disintegration products on the floors, such as chaotic materials, or from eolian influx. But overall it is likely that the additional material is volcanic and that it forms mostly the upper, more diversely bedded layers of the interior deposits.

The Skaergaard trough layering: sedimentation in a convecting magma chamber

NASA Astrophysics Data System (ADS)

Vukmanovic, Z.; Holness, M. B.; Monks, K.; Andersen, J. C. Ø.

2018-05-01

The upper parts of the floor cumulates of the Skaergaard Intrusion, East Greenland, contain abundant features known as troughs. The troughs are gently plunging synformal structures comprising stacks of crescentic modally graded layers with a sharply defined mafic base that grades upward into plagioclase-rich material. The origin of the troughs and layering is contentious, attributed variously to deposition of mineral grains by magmatic currents descending from the nearby walls, or to in situ development by localised recrystallisation during gravitationally-driven compaction. They are characterised by outcrop-scale features such as mineral lineations parallel to the trough axis, evidence of erosion and layer truncation associated with migration of the trough axis, and disruption of layering by syn-magmatic slumping. A detailed microstructural study of the modal trough layers, using electron backscatter diffraction together with geochemical mapping, demonstrates that these rocks do not record evidence for deformation by either dislocation creep or dissolution-reprecipitation. Instead, the troughs are characterised by the alignment of euhedral plagioclase crystals with unmodified primary igneous compositional zoning. We argue that the lineations and foliations are, therefore, a consequence of grain alignment during magmatic flow. Post-accumulation amplification of the modal layering occurred as a result of differential migration of an unmixed immiscible interstitial liquid, with upwards migration of the Si-rich conjugate into the plagioclase-rich upper part of the layers, whereas the Fe-rich immiscible conjugate remained in the mafic base. Both field and microstructure evidence support the origin of the troughs as the sites of repeated deposition from crystal-rich currents descending from the nearby chamber walls.

Intersection

NASA Technical Reports Server (NTRS)

2006-01-01

9 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a small portion of a dust-covered plain directly north of Labyrinthus Noctis which is cut by three linear troughs. The two long troughs running diagonally from the lower left (southwest) to the upper right (northeast) are connected by a third, shorter trough. Boulders derived from erosion of layered rock in the trough walls are seen perched on the sloping sidewalls and resting on the trough floors among giant windblown ripples.

Location near: 0.2oN, 105.0oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Northern Spring

Bedrock morphology reveals drainage network in northeast Baffin Bay

NASA Astrophysics Data System (ADS)

Slabon, Patricia; Dorschel, Boris; Jokat, Wilfried; Freire, Francis

2018-02-01

A subglacial drainage network underneath the paleo-ice sheet off West Greenland is revealed by a new compilation of high-resolution bathymetry data from Melville Bay, northeast Baffin Bay. This drainage network is an indicator for ice streaming and subglacial meltwater flow toward the outer shelf. Repeated ice sheet advances and retreats across the crystalline basement together with subglacial meltwater drainage had their impact in eroding overdeepened troughs along ice stream pathways. These overdeepenings indicate the location of a former ice sheet margin. The troughs inherit characteristics of glacial and subglacial meltwater erosion. Most of the troughs follow tectonic weakness zones such as faults and fractures in the crystalline bedrock. Many of these tectonic features correspond with the orientations of major fault axes in the Baffin Bay region. The troughs extend from the present (sub) glacial fjord systems at the Greenland coast and parallel modern outlet-glacier pathways. The fast flowing paleo-ice streams were likely accelerated from the meltwater flow as indicated by glacial landforms within and along the troughs. The ice streams flowed along narrow tributary troughs and merged to form large paleo-ice streams bedded in the major cross-shelf troughs of Melville Bay. Apart from the troughs, a rough seabed topography characterises the bedrock, and we see a sharp geomorphic transition where ice flowed onto sedimentary rock and deposits.

Seasonal variation and solar activity dependence of the quiet-time ionospheric trough

NASA Astrophysics Data System (ADS)

Ishida, T.; Ogawa, Y.; Kadokura, A.; Hiraki, Y.; Häggström, I.

2014-08-01

We have conducted a statistical analysis of the ionospheric F region trough, focusing on its seasonal variation and solar activity dependence under geomagnetically quiet and moderate conditions, using plasma parameter data obtained via Common Program 3 observations performed by the European Incoherent Scatter (EISCAT) radar between 1982 and 2011. We have confirmed that there is a major difference in frictional heating between the high- and low-latitude sides of the EISCAT field of view (FOV) at ~73°0'N-60°5'N (geomagnetic latitude) at an altitude of 325 km, which is associated with trough formation. Our statistical results show that the high-latitude and midlatitude troughs occur on the high- and low-latitude sides of the FOV, respectively. Seasonal variations indicate that dissociative recombination accompanied by frictional heating is a main cause of trough formation in sunlit regions. During summer, therefore, the occurrence rate is maintained at 80-90% in the postmidnight high-latitude region owing to frictional heating by eastward return flow. Solar activity dependence on trough formation indicates that field-aligned currents modulate the occurrence rate of the trough during the winter and equinox seasons. In addition, the trough becomes deeper via dissociative recombination caused by an increased ion temperature with F10.7, at least in the equinox and summer seasons but not in winter.

Increased water contamination and grow-out Pekin duck mortality when raised with water troughs compared to pin-metered water lines using a United States management system

PubMed Central

Schenk, A.; Porter, A. L.; Alenciks, E.; Frazier, K.; Best, A. A.; Fraley, S. M.; Fraley, G. S.

2016-01-01

Controversy has developed as to whether or not pin-metered water lines or water troughs are more appropriate for Pekin ducks. We hypothesized that water troughs would show improved duck body conditions and environmental quality compared to pin-metered water lines. To test this hypothesis, we housed ducks in 2 barns, one with water lines and one with water troughs. Water troughs were constructed to meet RSPCA guidelines for number and density of ducks and with recently described verandas. Ducks were divided into 4 pens per barn (n = 1,000 ducks/pen). The study was then repeated (n = 8 pens per water source) in a cross-over design so the barns each contained the opposite water source to the first experiment. We scored the ducks’ body condition using an established scoring rubric and analyzed using SAS Proc GLM-Mix as binomial data. Ducks housed with water troughs showed higher (thus worse condition; P < 0.001) scores for eyes, nostrils, feather quality, feather cleanliness, and foot pads. We also compared water condition, water quality, and duck mortality using a Student t test for both water sources each week. We found that the water troughs showed higher iron (P < 0.001), nitrites (P < 0.001), pH (P < 0.01), and bacterial growth (P < 0.001). The bacterial growth was shown to have higher (P < 0.001) E. coli, coliforms, and Staphylococcus in the water troughs. Water lines typically showed no bacterial growth in culture-based assays. Ducks housed with water troughs used greater (P = 0.001) volumes of water compared to ducks housed with water lines. Ducks with water troughs also showed a greater percent (P = 0.008) mortality at all ages compared to ducks with water lines. These data suggest that water troughs may not be beneficial for duck welfare and could adversely impact both environment and duck or human health. PMID:26769272

Increased water contamination and grow-out Pekin duck mortality when raised with water troughs compared to pin-metered water lines using a United States management system.

PubMed

Schenk, A; Porter, A L; Alenciks, E; Frazier, K; Best, A A; Fraley, S M; Fraley, G S

2016-04-01

Controversy has developed as to whether or not pin-metered water lines or water troughs are more appropriate for Pekin ducks. We hypothesized that water troughs would show improved duck body conditions and environmental quality compared to pin-metered water lines. To test this hypothesis, we housed ducks in 2 barns, one with water lines and one with water troughs. Water troughs were constructed to meet RSPCA guidelines for number and density of ducks and with recently described verandas. Ducks were divided into 4 pens per barn (n=1,000 ducks/pen). The study was then repeated (n=8 pens per water source) in a cross-over design so the barns each contained the opposite water source to the first experiment. We scored the ducks' body condition using an established scoring rubric and analyzed using SAS Proc GLM-Mix as binomial data. Ducks housed with water troughs showed higher (thus worse condition; P<0.001) scores for eyes, nostrils, feather quality, feather cleanliness, and foot pads. We also compared water condition, water quality, and duck mortality using a Student t test for both water sources each week. We found that the water troughs showed higher iron (P<0.001), nitrites (P<0.001), pH (P<0.01), and bacterial growth (P<0.001). The bacterial growth was shown to have higher (P<0.001)E. coli, coliforms, and Staphylococcusin the water troughs. Water lines typically showed no bacterial growth in culture-based assays. Ducks housed with water troughs used greater (P=0.001) volumes of water compared to ducks housed with water lines. Ducks with water troughs also showed a greater percent (P=0.008) mortality at all ages compared to ducks with water lines. These data suggest that water troughs may not be beneficial for duck welfare and could adversely impact both environment and duck or human health. © The Author 2016. Published by Oxford University Press on behalf of Poultry Science Association.

Structural features related to the volcanic gases in Southern Okinawa Trough

NASA Astrophysics Data System (ADS)

Wang, H. F.; Hsu, S. K.; Tsia, C. H.; Chen, S. C.; Wu, M. F.

2016-12-01

The Okinawa Trough is a rifted back-arc basin, heavily sedimented and formed in an intracontinental rift zone behind the Ryukyu trench-arc system. The Southern Okinawa Trough (SOT) east of Taiwan is the place where post-collisional extension happened. The collision moved southwestward and the Ryukyu trench-arc extension westward, Arc volcanism is dominant in the Northern Ryukyu volcanic arc and back-arc volcanism in the Southern Okinawa Trough. Marine geophysical data including side-scan sonar (SSS), sub-bottom profiler (SBP) and echo sounder system (EK60) data are used in this study. Active fluid activities out of seafloor are obvious from various images observed on these data, such as gas plumes. These hydrothermal vents have been located at a water depth of 1400 m. Our preliminary results show that gas seepage structures appear in the location where is a week zone, such as a normal fault in the slope. The hydrothermal activity within the Okinawa Trough is associated with volcanism located in rift zones in the Southern Okinawa Trough. However, the origin of the submarine hydrothermal fluids within the Okinawa Trough is diverse with contributions from volcanic, sedimentary and magmatic sources, needed further investigations.

A V-band wafer probe using ridge-trough waveguide

NASA Astrophysics Data System (ADS)

Godshalk, Edward M.

1991-12-01

A V-band (50-75 GHz) wafer probe is presented. The probe features a type of waveguide developed to allow transition from rectangular waveguide to coplanar waveguide. The waveguide consists of a ridge extending from the upper waveguide wall into a trough in the lower waveguide wall, and is known as the ridge-trough waveguide. A mathematical model is presented that allows important properties of the ridge-trough waveguide, such as the cutoff frequency and characteristic impedance, to be calculated.

Modern Multi-line Slot Machine Games: The Effect of Lines Wagered on Winners, Losers, Bonuses, and Losses Disguised as Wins.

PubMed

Harrigan, K; Dixon, M; Brown, D

2015-06-01

We simulated the commercially available multi-line slot machine game "Money Storm," including its bonus wins. Our results show that after a specified amount of time (such as 1 or 50 h), when players played a single line, there were marked differences between one player and the next-a few won a lot, others lost far more than average. When playing 20 lines there were fewer big winners and fewer players quickly losing a large percentage of their money. We simulated a Gambler's Ruin scenario whereby players arrived with $100 and made $1 wagers until broke. Again we saw a reduction in the variability among player as the number of lines wagered increased, fewer players lost their entire bankroll quickly, and fewer players had big wins. The bonus wins in Money Storm contribute approximately 24% to the payback of the game, and our simulations of bonus wins shows that with 20 lines wagered the players spend approximately 11% of their time in bonus wins. With one line wagered, there are no losses disguised as wins while with 20 lines wagered the majority of hits are losses disguised as wins. Players using multi-line machines can thus tune the characteristics of the machine gambling experience to match their preferred pattern, though most seem in practice to bet on the most possible lines. Our results serve to inform researchers, counsellors, gamblers and others about how slot machines are designed, and the effect that wagering on multiple lines has on short-term and long-term play, bonus wins, and losses disguised as wins.

Lost in Translation (LiT)

PubMed Central

Dollery, Colin T

2014-01-01

Translational medicine is a roller coaster with occasional brilliant successes and a large majority of failures. Lost in Translation 1 (‘LiT1’), beginning in the 1950s, was a golden era built upon earlier advances in experimental physiology, biochemistry and pharmacology, with a dash of serendipity, that led to the discovery of many new drugs for serious illnesses. LiT2 saw the large-scale industrialization of drug discovery using high-throughput screens and assays based on affinity for the target molecule. The links between drug development and university sciences and medicine weakened, but there were still some brilliant successes. In LiT3, the coverage of translational medicine expanded from molecular biology to drug budgets, with much greater emphasis on safety and official regulation. Compared with R&D expenditure, the number of breakthrough discoveries in LiT3 was disappointing, but monoclonal antibodies for immunity and inflammation brought in a new golden era and kinase inhibitors such as imatinib were breakthroughs in cancer. The pharmaceutical industry is trying to revive the LiT1 approach by using phenotypic assays and closer links with academia. LiT4 faces a data explosion generated by the genome project, GWAS, ENCODE and the ‘omics’ that is in danger of leaving LiT4 in a computerized cloud. Industrial laboratories are filled with masses of automated machinery while the scientists sit in a separate room viewing the results on their computers. Big Data will need Big Thinking in LiT4 but with so many unmet medical needs and so many new opportunities being revealed there are high hopes that the roller coaster will ride high again. PMID:24428732

Lost in Translation (LiT): IUPHAR Review 6.

PubMed

Dollery, Colin T

2014-05-01

Translational medicine is a roller coaster with occasional brilliant successes and a large majority of failures. Lost in Translation 1 ('LiT1'), beginning in the 1950s, was a golden era built upon earlier advances in experimental physiology, biochemistry and pharmacology, with a dash of serendipity, that led to the discovery of many new drugs for serious illnesses. LiT2 saw the large-scale industrialization of drug discovery using high-throughput screens and assays based on affinity for the target molecule. The links between drug development and university sciences and medicine weakened, but there were still some brilliant successes. In LiT3, the coverage of translational medicine expanded from molecular biology to drug budgets, with much greater emphasis on safety and official regulation. Compared with R&D expenditure, the number of breakthrough discoveries in LiT3 was disappointing, but monoclonal antibodies for immunity and inflammation brought in a new golden era and kinase inhibitors such as imatinib were breakthroughs in cancer. The pharmaceutical industry is trying to revive the LiT1 approach by using phenotypic assays and closer links with academia. LiT4 faces a data explosion generated by the genome project, GWAS, ENCODE and the 'omics' that is in danger of leaving LiT4 in a computerized cloud. Industrial laboratories are filled with masses of automated machinery while the scientists sit in a separate room viewing the results on their computers. Big Data will need Big Thinking in LiT4 but with so many unmet medical needs and so many new opportunities being revealed there are high hopes that the roller coaster will ride high again. © 2014 The British Pharmacological Society.

Probable hydrologic effects of a hypothetical failure of Mackay Dam on the Big Lost River Valley from Mackay, Idaho to the Idaho National Engineering Laboratory

USGS Publications Warehouse

Druffel, Leroy; Stiltner, Gloria J.; Keefer, Thomas N.

1979-01-01

Mackay Dam is an irrigation reservoir on the Big Lost River, Idaho, approximately 7.2 kilometers northwest of Mackay, Idaho. Consequences of possible rupture of the dam have long concerned the residents of the river valley. The presence of reactors and of a management complex for nuclear wastes on the reservation of the Idaho National Engineering Laboratory (INEL), near the river , give additional cause for concern over the consequences of a rupture of Mackay Dam. The objective of this report is to calculate and route the flood wave resulting from the hypothetical failure of Mackay Dam downstream to the INEL. Both a full and a 50 percent partial breach of this dam are investigated. Two techniques are used to develop the dam-break model. The method of characteristics is used to propagate the shock wave after the dam fails. The linear implicit finite-difference solution is used to route the flood wave after the shock wave has dissipated. The time of travel of the flood wave, duration of flooding, and magnitude of the flood are determined for eight selected sites from Mackay Dam, Idaho, through the INEL diversion. At 4.2 kilometers above the INEL diversion, peak discharges of 1,550.2 and 1,275 cubic meters per second and peak flood elevations of 1,550.3 and 1,550.2 meters were calculated for the full and partial breach, respectively. Flood discharges and flood peaks were not compared for the area downstream of the diversion because of the lack of detailed flood plain geometry. (Kosco-USGS)

Parabolic Trough Collector Cost Update for the System Advisor Model (SAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurup, Parthiv; Turchi, Craig S.

2015-11-01

This report updates the baseline cost for parabolic trough solar fields in the United States within NREL's System Advisor Model (SAM). SAM, available at no cost at https://sam.nrel.gov/, is a performance and financial model designed to facilitate decision making for people involved in the renewable energy industry. SAM is the primary tool used by NREL and the U.S. Department of Energy (DOE) for estimating the performance and cost of concentrating solar power (CSP) technologies and projects. The study performed a bottom-up build and cost estimate for two state-of-the-art parabolic trough designs -- the SkyTrough and the Ultimate Trough. The SkyTroughmore » analysis estimated the potential installed cost for a solar field of 1500 SCAs as $170/m 2 +/- $6/m 2. The investigation found that SkyTrough installed costs were sensitive to factors such as raw aluminum alloy cost and production volume. For example, in the case of the SkyTrough, the installed cost would rise to nearly $210/m 2 if the aluminum alloy cost was $1.70/lb instead of $1.03/lb. Accordingly, one must be aware of fluctuations in the relevant commodities markets to track system cost over time. The estimated installed cost for the Ultimate Trough was only slightly higher at $178/m 2, which includes an assembly facility of $11.6 million amortized over the required production volume. Considering the size and overall cost of a 700 SCA Ultimate Trough solar field, two parallel production lines in a fully covered assembly facility, each with the specific torque box, module and mirror jigs, would be justified for a full CSP plant.« less

Geophysical basin structure of the Cotonou (Dahomey/Benin) basin, West African Gulf of Guinea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babalola, O.O.

1990-05-01

The frontier Cotonou basin (or Dahomey/Benin embayment), situated west of the prolific Niger Delta basin, appears from seismic, gravity, and aeromagnetic interpretation, as a series of grabens and troughs confined on the west and east by the Romanche and the Chain fracture zones, respectively. The Keta trough of the western basin rim was formed by a 2700-m southeasterly downthrow of the Adina fault. This trough is separated by a north-northeasterly fault from the Lome-Anecho gravity high. Eastward, the arcuate Allada-Adjohon trough is abutted on its southern flank by the northwest-trending Nokue-Afowo trough and separated from the northwesterly Ikorodu trough bymore » the 50-km-wide aeromagnetically inferred ro-Otta ridge. The Ikorodu trough is adjoined on the northwest by the Aiyetoro trough and on the southeast by the Yemoja offshore graben trending east northeast as the Seme oil-field structural trend. North of the regional northeasterly axial, gravity positive, structural divide (the continental precursor of the Charcot fracture zone) a series of half-grabens (notably the Aplahoue, Bohicon, and Keiou troughs), normal faulted eastward and downthrown in the west, dominate the landward western rim of the Cotonou basin. Graben-bounding faults control the upper valleys of the basin drainage, converge toward the regional intrabasin structural trend and continue into the Fenyi-koe fault and the Charcot fracture zone. These faults resulted from brittle dextral shear of continental crust oblique to local, preexisting north-northeast structural trends. In the eastern basin rim, preexisting north-northwest structural trends influenced the shearing stress regime to generate small, shallow, structurally bounded, east-northeast- and north-northwest trending grabens.« less

Self-organized criticality in sandpiles - Nature of the critical phenomenon. [dynamic models in phase transition

NASA Technical Reports Server (NTRS)

Carlson, J. M.; Chayes, J. T.; Swindle, G. H.; Grannan, E. R.

1990-01-01

The scaling behavior of sandpile models is investigated analytically. First, it is shown that sandpile models contain a set of domain walls, referred to as troughs, which bound regions that can experience avalanches. It is further shown that the dynamics of the troughs is governed by a simple set of rules involving birth, death, and coalescence events. A simple trough model is then introduced, and it is proved that the model has a phase transition with the density of the troughs as an order parameter and that, in the thermodynamic limit, the trough density goes to zero at the transition point. Finally, it is shown that the observed scaling behavior is a consequence of finite-size effects.

The impact of the structural features of the rock mass on seismicity in Polish coal mines

NASA Astrophysics Data System (ADS)

Patyńska, Renata

2017-11-01

The article presents seismic activity induced in the coal mines of the Upper Silesian Coal Basin (GZW) in relation to the locations of the occurrence of rockbursts. The comparison of these measurements with the structural features of the rock mass of coal mines indicates the possibility of estimating the so-called Unitary Energy Expenditure (UEE) in a specific time. The obtained values of UEE were compared with the distribution of seismic activity in GZW mines. The level of seismic activity in the analysed period changed and depended on the intensity of mining works and diverse mining and geological conditions. Five regions, where tremors occurred (Bytom Trough, Main Saddle, Main Trough, Kazimierz Trough, and Jejkowice and Chwałowice Trough) which belong to various structural units of the Upper Silesia were analyzed. It was found out that rock bursts were recorded only in three regions: Main Saddle, Bytom Trough, and Jejkowice and Chwałowice Trough.

Stress Fields Along Okinawa Trough and Ryukyu Arc Inferred From Regional Broadband Moment Tensors

NASA Astrophysics Data System (ADS)

Kubo, A.; Fukuyama, E.

2001-12-01

Most shallow earthquakes along Okinawa trough and Ryukyu arc are relatively small (M<5.5). Focal mechanism estimations for such events were difficult due to insufficient dataset. However, this situation is improved by regional broadband network (FREESIA). Lower limit of magnitude of the earthquakes determined becomes 1.5 smaller in M{}w than that of Harvard moment tensors. As a result, we could examine the stress field in more detail than Fournier et al.(2001, JGR, 106, 13751-) did based on surface geology and teleseismic moment tensors. In the NE Okinawa trough, extension axes are oblique to the trough strike, while in SW Okinawa trough, they are perpendicular to the trough. Fault type in SW is normal fault and gradually changes to mixture of normal and strike slip toward NE. In the Ryukyu arc, extension axes are parallel to the arc. Although this feature is not clear in the NW Ryukyu arc, arc parallel extension may be a major property of entire arc. Dominant fault type is normal fault and several strike slips with the same extensional component are included. The volcanic train is located at the edge of arc parallel extension field faced A simple explanation of the arc parallel extension is the response to the opening motion of the Okinawa trough. Another possible mechanism is forearc movement due to oblique subduction which is enhanced in SW. We consider that the Okinawa trough and the Ryukyu arc are independent stress provinces.

Big Crater as Viewed by Pathfinder Lander

NASA Technical Reports Server (NTRS)

1997-01-01

The 'Big Crater' is actually a relatively small Martian crater to the southeast of the Mars Pathfinder landing site. It is 1500 meters (4900 feet) in diameter, or about the same size as Meteor Crater in Arizona. Superimposed on the rim of Big Crater (the central part of the rim as seen here) is a smaller crater nicknamed 'Rimshot Crater.' The distance to this smaller crater, and the nearest portion of the rim of Big Crater, is 2200 meters (7200 feet). To the right of Big Crater, south from the spacecraft, almost lost in the atmospheric dust 'haze,' is the large streamlined mountain nicknamed 'Far Knob.' This mountain is over 450 meters (1480 feet) tall, and is over 30 kilometers (19 miles) from the spacecraft. Another, smaller and closer knob, nicknamed 'Southeast Knob' can be seen as a triangular peak to the left of the flanks of the Big Crater rim. This knob is 21 kilometers (13 miles) southeast from the spacecraft.

The larger features visible in this scene - Big Crater, Far Knob, and Southeast Knob - were discovered on the first panoramas taken by the IMP camera on the 4th of July, 1997, and subsequently identified in Viking Orbiter images taken over 20 years ago. The scene includes rocky ridges and swales or 'hummocks' of flood debris that range from a few tens of meters away from the lander to the distance of South Twin Peak. The largest rock in the nearfield, just left of center in the foreground, nicknamed 'Otter', is about 1.5 meters (4.9 feet) long and 10 meters (33 feet) from the spacecraft.

This view of Big Crater was produced by combining 6 individual 'Superpan' scenes from the left and right eyes of the IMP camera. Each frame consists of 8 individual frames (left eye) and 7 frames (right eye) taken with different color filters that were enlarged by 500% and then co-added using Adobe Photoshop to produce, in effect, a super-resolution panchromatic frame that is sharper than an individual frame would be.

Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

Crustal Density Variation Along the San Andreas Fault Controls Its Secondary Faults Distribution and Dip Direction

NASA Astrophysics Data System (ADS)

Yang, H.; Moresi, L. N.

2017-12-01

The San Andreas fault forms a dominant component of the transform boundary between the Pacific and the North American plate. The density and strength of the complex accretionary margin is very heterogeneous. Based on the density structure of the lithosphere in the SW United States, we utilize the 3D finite element thermomechanical, viscoplastic model (Underworld2) to simulate deformation in the San Andreas Fault system. The purpose of the model is to examine the role of a big bend in the existing geometry. In particular, the big bend of the fault is an initial condition of in our model. We first test the strength of the fault by comparing the surface principle stresses from our numerical model with the in situ tectonic stress. The best fit model indicates the model with extremely weak fault (friction coefficient < 0.1) is requisite. To the first order, there is significant density difference between the Great Valley and the adjacent Mojave block. The Great Valley block is much colder and of larger density (>200 kg/m3) than surrounding blocks. In contrast, the Mojave block is detected to find that it has lost its mafic lower crust by other geophysical surveys. Our model indicates strong strain localization at the jointer boundary between two blocks, which is an analogue for the Garlock fault. High density lower crust material of the Great Valley tends to under-thrust beneath the Transverse Range near the big bend. This motion is likely to rotate the fault plane from the initial vertical direction to dip to the southwest. For the straight section, north to the big bend, the fault is nearly vertical. The geometry of the fault plane is consistent with field observations.

Trough Coating Solar Cells Without Spillover

NASA Technical Reports Server (NTRS)

Heaps, J. D.

1986-01-01

Problem with trough coating of silicon on ceramic - spillover of molten silicon - overcome by combination of redesigned heaters and tiltable trough. Modifications make it possible to coat virtually any length of ceramic with film of solar-cell-grade silicon. Previously, maximum length coated before spillover occurred was 2 inches (5.1 cm).

Labeatis Trough

NASA Technical Reports Server (NTRS)

2006-01-01

2 July 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a trough cutting across a dust-covered plain in the Labeatis Fossae region of Mars. Boulders derived from the layered exposures near the top of the trough walls are resting on the floor, and in some locations, the sloping sidewalls of the dusty trough.

Location near: 22.1oN, 94.5oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Spring

Technical Manual for the SAM Physical Trough Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, M. J.; Gilman, P.

2011-06-01

NREL, in conjunction with Sandia National Lab and the U.S Department of Energy, developed the System Advisor Model (SAM) analysis tool for renewable energy system performance and economic analysis. This paper documents the technical background and engineering formulation for one of SAM's two parabolic trough system models in SAM. The Physical Trough model calculates performance relationships based on physical first principles where possible, allowing the modeler to predict electricity production for a wider range of component geometries than is possible in the Empirical Trough model. This document describes the major parabolic trough plant subsystems in detail including the solar field,more » power block, thermal storage, piping, auxiliary heating, and control systems. This model makes use of both existing subsystem performance modeling approaches, and new approaches developed specifically for SAM.« less

Pennsylvanian-Permian tectonism in the Great Basin: The Dry Mountain trough and related basins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snyder, W.S.; Spinosa, C.; Gallegos, D.M.

1991-02-01

Pennsylvanian-Permian tectonism affected the continental margin of western North America from the Yukon to the Mojave Desert. Specific signatures of this tectonism include local angular unconformities, regional disconformities, renewed outpouring of clastic debris from a reactivated Antler and related highlands, and development of deeper water basins with anoxic sediments deposited below wave base. The basins formed include Ishbel trough (Canada), the Wood River basin (Idaho), Cassia basin, Ferguson trough, Dry Mountain trough (all Nevada), and unnamed basins in Death Valley-Mojave Desert region. The Dry Mountain trough (DMT) was initiated during early Wolfcampian and received up to 1,200 m of sedimentmore » by the late Leonardian. The lower contact is a regional unconformity with the Ely Limestone, or locally with the Diamond Peak or Vinini formations. Thus, following a period of localized regional uplift that destroyed the Ely basin, portions of the uplifted and exposed shelf subsided creating the Dry Mountain trough. Evidence suggesting a tectonic origin for the DMT includes (1) high subsidence rates (60-140 m/m.y.); (2) renewed influx of coarse clastic debris from the Antler highlands: (3) possible pre-Early Permian folding, thrusting, and tilting within the highlands; and (4) differential subsidence within the Dry Mountain trough, suggesting the existence of independent fault blocks.« less

Present-day erosion of Martian polar terrain by the seasonal CO2 jets

NASA Astrophysics Data System (ADS)

Portyankina, Ganna; Hansen, Candice J.; Aye, Klaus-Michael

2017-01-01

Here we report on the detection of new dendritic troughs created by the seasonal CO2 jet activity over several Martian years. According to Kieffers hypothesis (Kieffer, 2007) in Martian polar areas seasonal CO2 ice sublimation creates gas jets that deposit fans of mineral dust and sand on top of the CO2 ice. These jets and the related sub-ice gas flows are believed to carve troughs in the underlying polar deposits which, after multiple repetitions of this process throughout Martian spring seasons, create araneiform terrains. The High Resolution Imaging Science Experiment (HiRISE) on the Mars Reconnaissance Orbiter (MRO) detected the new troughs during its campaign for seasonal monitoring of the polar areas. The newly detected dendritic troughs are small shallow branching troughs (≈ 1.4 m wide) similar to the seasonal furrows previously detected in the northern hemisphere (Bourke, 2013). The essential difference between the new troughs and furrows lies in the fact that the troughs in the south are persistent while the northern furrows are erased each Martian year by the sand movement due to summer winds. From year to year the new southern troughs extend and develop new tributaries and their overall geometry turns from linear to dendritic, a characteristic shared with araneiform terrains. We believe that furrows have the same origin as the southern dendritic troughs but do not develop into dendritic shapes because of the high mobility of the dune material into which they are carved. Several locations where new dendritic troughs are observed lie in the vicinity of dunes. This gives us an observational indication that presence of erosive sand material is an important factor in creating (or at least starting) erosive processes that lead to the formation of dendritic troughs. By extrapolation the same mechanism should be acting to create the much larger araneiform terrains. Detection of the present day erosion working in polar areas and creating new topographical features is important for understanding of the processes that shape polar areas. Several years of HiRISE observations provide us with the information about the current rate of erosion and hence help estimate minimum ages of the araneiforms and the surface into which they are carved to be 1.3 × 103 Martian years.

Applications of digital image analysis capability in Idaho

NASA Technical Reports Server (NTRS)

Johnson, K. A.

1981-01-01

The use of digital image analysis of LANDSAT imagery in water resource assessment is discussed. The data processing systems employed are described. The determination of urban land use conversion of agricultural land in two southwestern Idaho counties involving estimation and mapping of crop types and of irrigated land is described. The system was also applied to an inventory of irrigated cropland in the Snake River basin and establishment of a digital irrigation water source/service area data base for the basin. Application of the system to a determination of irrigation development in the Big Lost River basin as part of a hydrologic survey of the basin is also described.

Verification of the modelling of the main ionospheric trough by the Electron Density Assimilative Model (EDAM)

NASA Astrophysics Data System (ADS)

Parker, James; Pryse, Eleri; Jackson-Booth, Natasha

2017-04-01

The main ionospheric trough is a large-scale spatial depletion in the ionospheric electron density that commonly separates the auroral and mid-latitude regions. The feature covers several degrees in latitude and is extended in longitude. It exhibits substantial day-to-day variability in both the location of its minimum ionisation density and in its latitudinal structure. Observations from the UK have shown the trough to be a night-time feature, appearing in early evening to the north of the mainland and progressing equatorward during the course of the night. At dawn, photoionisation fills in the feature. Under increasing levels of geomagnetic activity, the trough moves progressively to lower latitudes. Steep gradients on the trough walls and their variability can cause problems for radio applications. EDAM can be used to model the ionosphere at the trough latitudes by assimilating ionospheric observations from this region into the International Reference Ionosphere (IRI). In this study troughs modelled by EDAM, assimilating data for a period from September to December 2002, are presented and are verified by comparisons with independent observations. Measurements of slant total electron content (sTEC) between GPS satellites and forty ground receivers in Europe were assimilated into EDAM to model the ionospheric electron density. The Vertical Total Electron Content (VTEC) was then calculated through the model, with the values at the longitude of 0.0E considered to obtain statistical characteristics of identified troughs parameters. Comparisons of the parameters with those obtained previously, using transmissions from the satellites of NIMS (Navy Ionospheric Monitoring System) orbiting at altitudes lower than GPS, revealed consistent results. Further support for the EDAM trough was obtained by comparisons of the model with independent GPS measurements. For this a GPS ground station not used in the assimilation was used to observe the sTEC to this "truth" station. Comparisons of these independent truth data with sTEC calculated through the model were used to determine the accuracy of EDAM in the vicinity of the trough.

Topography and Stratigraphy of the Northern Martian Polar Layered Deposits Using Photoclinometry, Stereogrammetry, and MOLA Altimetry

USGS Publications Warehouse

Fenton, L.K.; Herkenhoff, K. E.

2000-01-01

We present two photoclinometric profiles across a trough in the martian northern polar layered terrain. Complications caused by albedo variations were avoided by using an early springtime Viking image with a thin cover of seasonal CO2 frost. The topographic profiles were constrained with stereogrammetric elevations derived from summertime Viking images of the same region. We find that the photoclinometric profiles are consistent with a nearby MOLA (Mars Orbiter Laser Altimeter) track crossing the same polar trough. The trough is asymmetric, with higher relief and a steeper slope on the equatorward-facing wall. Individual layers are subdued and difficult to observe in the profiles. A decrease in both relief and elevation toward the eastern end of the trough suggests that layers become thinner to the east. Declining equatorward slopes in the eastern portion of the trough imply that erosion rates have varied along the trough. The variation in erosion rate may be linked to the change in layer thickness along the trough. Layers have an average thickness of 19??8 m in the center of the trough and 59??32 m on the northern wall. The northern wall is most likely composed of thinner layers that are obscured. To first order, we find that a 19-m layer requires 16,000 years of deposition to form. Although this timescale does not coincide with orbital variation periods of 105 and 106 years, deposition rates may not be constant and thus the 16,000-year layer formation time does not preclude layer formation during part of each orbital oscillation. ?? 2000 Academic Press.

Meta-analysis of medical intervention for normal tension glaucoma.

PubMed

Cheng, Jin-Wei; Cai, Ji-Ping; Wei, Rui-Li

2009-07-01

To evaluate the intraocular pressure (IOP) reduction achieved by the most frequently prescribed antiglaucoma drugs in patients with normal tension glaucoma (NTG). Systematic review and meta-analysis. Fifteen randomized clinical trials reported 25 arms for peak IOP reduction, 16 arms for trough IOP reduction, and 13 arms for diurnal curve IOP reduction. Pertinent publications were identified through systematic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register. The patients had to be diagnosed as having NTG. Methodological quality was assessed by the Delphi list on a scale from 0 to 18. The pooled 1-month IOP-lowering effects were calculated using the 2-step DerSimonian and Laird estimate method of the random effects model. Absolute and relative reductions in IOP from baseline for peak and trough moments. Quality scores of included studies were generally high, with a mean quality score of 12.7 (range, 9-16). Relative IOP reductions were peak, 15% (12%-18%), and trough, 18% (8%-27%) for timolol; peak, 14% (8%-19%), and trough, 12% (-7% to 31%) for dorzolamide; peak, 24% (17%-31%), and trough, 11% (7%-14%) for brimonidine; peak, 20% (17%-24%), and trough, 20% (18%-23%) for latanoprost; peak, 21% (16%-25%), and trough, 18% (14%-22%) for bimatoprost. The differences in absolute IOP reductions between prostaglandin analogues and timolol varied from 0.9 to 1.0 mmHg at peak and -0.1 to 0.2 mmHg at trough. Latanoprost, bimatoprost, and timolol are the most effective IOP-lowering agents in patients with NTG.

9 CFR 82.21 - Vehicles, cages, coops, containers, troughs, and other equipment used for infected poultry.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., troughs, and other equipment used for infected poultry. 82.21 Section 82.21 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS EXOTIC NEWCASTLE DIS- EASE (END) AND CHLAMYDIOSIS Chlamydiosis in Poultry § 82.21 Vehicles, cages, coops, containers, troughs, and other equipment used for...

Evolution of the Outflows in NGC 3516

NASA Astrophysics Data System (ADS)

Dunn, Jay P.; Parvaresh, Rozhin; Kraemer, S. B.; Crenshaw, D. Michael

2018-02-01

We analyze the 2011 HST/COS spectrum of the Seyfert 1 galaxy NGC 3516, which demonstrates clear changes in one of the intrinsic absorption troughs (component 5), slight evidence of change in a second trough (component 6), and the appearance of a new absorption trough (component 9). We interpret both the changes and the appearance of the new trough as bulk motion across the line of sight. The implied lower limit on the transverse velocity of component 5 is 360 km s‑1, compared to the earlier 2001 HST/STIS spectrum, while the lower limits for components 6 and 9 are 920 km s‑1, based on 2009 FUSE data. Component 5 also exhibits a shift in velocity centroid. This is only the second known case of this behavior in a Seyfert galaxy. Due to the high quality of the HST/COS spectrum, we identify a previously undetected trough due to an excited state of Si II for component 1. In combination with the resonance trough of Si II and photoionization modeling, we directly determine the distance of the component 1 outflow to be 67.2 pc.

Prediction of Vancomycin Dose for Recommended Trough Concentrations in Pediatric Patients With Cystic Fibrosis.

PubMed

Amin, Raid W; Guttmann, Rodney P; Harris, Quianna R; Thomas, Janesha W

2018-05-01

Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus. The present study sought to develop a model based on empirical evidence of optimal vancomycin dose as judged by clinical observations that could accelerate the achievement of desired trough level in children with cystic fibrosis. Transformations of dose and trough were used to arrive at regression models with excellent fit for dose based on weight or age for a target trough. Results of this study indicate that the 2 proposed regression models are robust to changes in age or weight, suggesting that the daily dose on a per-kilogram basis is determined primarily by the desired trough level. The results show that to obtain a vancomycin trough level of 20 μg/mL, a dose of 80 mg/kg/day is needed. This analysis should improve the efficiency of vancomycin usage by reducing the number of titration steps, resulting in improved patient outcome and experience. © 2018, The American College of Clinical Pharmacology.

Geochemical and Sr-Nd-Pb-Li isotopic characteristics of volcanic rocks from the Okinawa Trough: Implications for the influence of subduction components and the contamination of crustal materials

NASA Astrophysics Data System (ADS)

Guo, Kun; Zhai, Shikui; Yu, Zenghui; Wang, Shujie; Zhang, Xia; Wang, Xiaoyuan

2018-04-01

The Okinawa Trough is an infant back-arc basin developed along the Ryukyu arc. This paper provides new major and trace element and Sr-Nd-Pb-Li isotope data of volcanic rocks in the Okinawa Trough and combines the published geochemical data to discuss the composition of magma source, the influence of subduction component, and the contamination of crustal materials, and calculate the contribution between subduction sediment and altered oceanic crust in the subduction component. The results showed that there are 97% DM and 3% EMI component in the mantle source in middle trough (MS), which have been influenced by subduction sediment. The Li-Nd isotopes indicate that the contribution of subduction sediment and altered oceanic crust in subduction component are 4 and 96%, respectively. The intermediate-acidic rocks suffer from contamination of continental crust material in shallow magma chamber during fractional crystallization. The acidic rocks in south trough have experienced more contamination of crustal material than those from the middle and north trough segments.

The noon and midnight mid-latitude trough as seen by Ariel 4

NASA Technical Reports Server (NTRS)

Tulunay, Y. K.; Grebowsky, J. M.

1978-01-01

The electron density data returned by the polar orbiting satellites Ariel 3 and Ariel 4 revealed that the midlatitude trough is one of the distinct large-scale features of the ionosphere at about 550 km. Recent work (e.g., Tulunay and Grebowsky, 1975) on the data included the investigation of the temporal development of the latitudinal position of the midlatitude electron density trough at dawn and dusk during the large magnetic storms of May 1967 and May 1972. Model calculations which assumed that the equatorial convection E-field varies in step with the Kp index reproduced on the average the observed behavior. In the present paper, trough observations made at noon and midnight during the period, 12-21 December 1971 which encompassed a relatively large magnetic storm are discussed. In this context, model calculations have been employed as a guide of average approximations of the actual situation in predicting the plasmapause location. It is also shown that the trough observed on the noon passes is not generally plasmapause-related as the nightside troughs are expected to be.

Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation.

PubMed

Ueshima, Satoshi; Hira, Daiki; Fujii, Ryo; Kimura, Yuuma; Tomitsuka, Chiho; Yamane, Takuya; Tabuchi, Yohei; Ozawa, Tomoya; Itoh, Hideki; Horie, Minoru; Terada, Tomohiro; Katsura, Toshiya

2017-09-01

During anticoagulant therapy, major bleeding is one of the most severe adverse effects. This study aimed to evaluate the relationships between ABCB1, ABCG2, and CYP3A5 polymorphisms and plasma trough concentrations of apixaban, a direct inhibitor of coagulation factor X. A total of 70 plasma concentrations of apixaban from 44 Japanese patients with atrial fibrillation were analyzed. In these analyses, the plasma trough concentration/dose (C/D) ratio of apixaban was used as a pharmacokinetic index and all data were stratified according to the presence of ABCB1 (ABCB1 1236C>T, 2677G>T/A, and 3435C>T), ABCG2 (ABCG2 421C>A), and CYP3A5 (CYP3A5*3) polymorphisms. Influences of various clinical laboratory parameters (age, serum creatinine, estimated glomerular filtration rate, aspartate amino transferase, and alanine amino transferase) on the plasma trough C/D ratio of apixaban were included in analyses. Although no ABCB1 polymorphisms affected the plasma trough C/D ratio of apixaban, the plasma trough C/D ratio of apixaban was significantly higher in patients with the ABCG2 421A/A genotype than in patients with the ABCG2 421C/C genotype (P<0.01). The plasma trough C/D ratio of apixaban in patients with CYP3A5*1/*3 or *3/*3 genotypes was also significantly higher than that in patients with the CYP3A5*1/*1 genotype (P<0.05). Furthermore, the plasma trough C/D ratio of apixaban decreased with increased estimated glomerular filtration rate. These results indicate that ABCG2 421A/A and CYP3A5*3 genotypes and renal function are considered potential factors affecting trough concentrations of apixaban.

Combination of AUV high resolution mapping and submersible visual observations on the Guaymas Hydrothermal Fields (Southern Trough Ridge)

NASA Astrophysics Data System (ADS)

Ondreas, H.; Fouquet, Y.; Normand, A.; Rouxel, O.; Godfroy, A.

2011-12-01

The BIG cruise -leg I- was carried out on the Guaymas basin in June 2010 on board the French research vessel L'Atalante. An AUV high-resolution survey was made on the southern trough ridge to gather fine-scale bathymetry and acoustic imagery data. The results of the high resolution survey were used, the next days, to explore the vent's area during several Nautile dives. The southern trough hydrothermal fields of the Guaymas basin have often been studied. However, the local geological context was not really well-defined. During the AUV surveys, maps at 70 m above the seafloor were done over the hydrothermal area. The data were gridded at 2 m spacing. During the same cruise, Nautile dives help us to compare the field observations and the geological features revealed by the high resolution mapping and to investigate the fine-scale relationships between the vents and their geological environment. Integration of these data is made easier by the use of the GIS software technology. It helps us perpetuate data, undertake comparisons, combine different types of data, realize fine-scale geological mapping. Even if some problems are recurrent (precision of positioning, integration of old data...), such combinations of high resolution mapping and visual observations and sampling have changed our vision of hydrothermal geological context. In the Guaymas sedimented spreading axis, our new data show that major hydrothermal sites, in the south part of the southern trough only, are located inside or at the border of 100 to 250 m long, 60 to 150 m wide, 6 to 12 m deep small collapsed sub-circular depressions. The direction of the collapse is variable. Curved faults at the outer border of these depressions control the largest and mature edifices. Smaller, possibly younger, immature chimneys are located at the centre of some depressions. The mature hydrothermal structures appear as mounds up to 80 m in diameter, 20 m in high, each hydrothermal edifice being very-well identified on the 2 m resolution map. Classical high temperature chimneys are present but also areas of high temperature fluids percolating through the petroleum-rich sediment. Echosounder profiles, realized near the bottom with the AUV, show the root of some hydrothermal edifice 40 m down in the sediment and their link with the small depressions. The profiles also show normal faults buried in the sediment and the collapsed depression controlling the hydrothermal edifices. The bordering curved-faults appear as superficial features. To explain the local features seen on high resolution data, we propose a succession of process: i) collapse related to deep recent fissuration in the volcanic basement, ii) discharge controlled along the border of the sub-circular collapse structures and starting of chimneys construction, iii) maturation of the external edifices and collapse of the depression enhanced by mobilisation of sediment out of the depression by fluid discharge.

A digital map of the high center (HC) and low center (LC) polygon boundaries delineated from high resolution LiDAR data for Barrow, Alaska

DOE Data Explorer

Gangodagamage, Chandana; Wullschleger, Stan

2014-07-03

This dataset represent a map of the high center (HC) and low center (LC) polygon boundaries delineated from high resolution LiDAR data for the arctic coastal plain at Barrow, Alaska. The polygon troughs are considered as the surface expression of the ice-wedges. The troughs are in lower elevations than the interior polygon. The trough widths were initially identified from LiDAR data, and the boundary between two polygons assumed to be located along the lowest elevations on trough widths between them.

Sedimentation and tectonics of the Sylhet trough, Bangladesh

USGS Publications Warehouse

Johnson, S.Y.; Nur Alam, A.M.

1991-01-01

The Sylhet trough, a sub-basin of the Bengal Basin in northeastern Bangladesh, contains a thick fill (12 to 16 km) of late Mesozoic and Cenozoic strata that record its tectonic evolution. Stratigraphic, sedimentologic, and petrographic data collected from outcrops, cores, well logs, and seismic lines are used to reconstruct the history of this trough. -from Authors

Numerical Optimization Using Desktop Computers

DTIC Science & Technology

1980-09-11

concentrating compound parabolic trough solar collector . Thermophysical, geophysical, optical and economic analyses were used to compute a life-cycle...third computer program, NISCO, was developed to model a nonimaging concentrating compound parabolic trough solar collector using thermophysical...concentrating compound parabolic trough Solar Collector . C. OBJECTIVE The objective of this thesis was to develop a system of interactive programs for the Hewlett

Concentrating Solar Power Projects - Yumen 50MW Thermal Oil Trough CSP

Science.gov Websites

project | Concentrating Solar Power | NREL Thermal Oil Trough CSP project Status Date : September 28, 2016 Project Overview Project Name: Yumen 50MW Thermal Oil Trough CSP project Country: China : Thermal Oil Power Block Turbine Capacity (Gross): 50.0 MW Turbine Capacity (Net): 50.0 MW Output Type

The Ordovician Sebree Trough: An oceanic passage to the Midcontinent United States

USGS Publications Warehouse

Kolata, Dennis R.; Huff, W.D.; Bergstrom, Stig M.

2001-01-01

The Sebree Trough is a relatively narrow, shale-filled sedimentary feature extending for several hundred kilometers across the Middle and Late Ordovician carbonate platform of the Midcontinent United States. The dark graptolitic shales within the trough stand in contrast to the coeval bryozoan-brachiopod-echinodermrich limestones on the flanking platforms. We infer from regional stratal patterns, thickness and facies trends, and temporal relations established by biostratigraphy and K-bentonite stratigraphy that the Sebree Trough initially began to develop during late Turinian to early Chatfieldian time (Mohawkian Series) as a linear bathymetric depression situated over the failed late Precambrian-Early Cambrian Reelfoot Rift. Rising sea level and positioning of a subtropical convergence zone along the southern margin of Laurentia caused the rift depression to descend into cool, oxygen-poor, phosphate-rich oceanic waters that entered the southern reaches of the rift from the Iapetus Ocean. The trough apparently formed in a system of epicontinental estuarine circulation marked by a density-stratified water column. Trough formation was accompanied by cessation of carbonate sedimentation, deposition of graptolitic shales, development of hardground omission surfaces, substrate erosion, and local phosphogenesis. The carbonate platforms on either side of the trough are dominated by bryozoan-brachiopod-echinoderm grainstones and packstones that were deposited in zones of mixing where cool, nutrient-rich waters encountered warmer shelf waters. Concurrently, lime mudstone and wackestone were deposited shoreward (northern Illinois, Wisconsin, Iowa, Minnesota, Michigan) in warmer, more tropical shallow seas. Coeval upward growth of the flanking carbonate platforms sustained and enhanced development of the trough shale facies. Five widespread diachronous late Mohawkian and Cincinnatian omission surfaces are present in the carbonate facies of the Midcontinent. These surfaces include sub-Deicke K-bentonite, DSI; top of Black River Limestone, DS2; base and top of the Guttenberg Limestone Member of the Decorah Formation, DS3 and DS4; and top of the Trenton Limestone, DS5. Some of the surfaces correspond to previously described depositional sequence boundaries. All five surfaces, which embody deepening phases on top of high-stand-systems tracts, converge in the Sebree Trough, indicating that the trough was a long-lived feature and was the source of eutrophic waters that episodically spread across the adjacent platforms, terminating carbonate production. Late Turinian and early Chatfieldian incipient drowning episodes were followed by a final drowning event that began in the Sebree Trough during the late Chatfieldian (Climacograptus spiniferus Zone) and reached southernmost Minnesota and other regions far within the platform interior by Richmondian time (Amorphognathus ordovicicus Zone).

Morphological evolution of Jinshan Trough in Hangzhou Bay (China) from 1960 to 2011

NASA Astrophysics Data System (ADS)

Liu, Yifei; Xia, Xiaoming; Chen, Shenliang; Jia, Jianjun; Cai, Tinglu

2017-11-01

An extensive system of tidal channels, starting with Jinshan Trough in the east, is located along the north shore of Hangzhou Bay, China. This contribution investigates the morphological evolution of Jinshan Trough by using 17 bathymetric charts from a series covering a period of 51 years from 1960 to 2011. Three stages of evolution during this period are distinguishable based on the morphology and annual mean volume data. The first stage (1960-1987) is characterized by extension of the trough; the second stage (1987-1996) is a relatively stable period with some adjustments in the trough morphology; the third stage (1996-2011) is marked by the processes of erosion and deposition in the beginning of the period and a subsequent slow erosion process. Spatio-temporal variability of the trough was evaluated by using empirical orthogonal function (EOF) analysis. The first eigenfunction indicates that erosion is the main evolution process and there exists three stages similar to those distinguished from volume variations. The second eigenfunction mainly reflects erosion and deposition in the northwest part of the trough located in the flood tidal current shadow area of the artificial headland in Jinshan. The third eigenfunction mainly reflects annual fluctuations of erosion and deposition in the side slope at the artificial headland in Jinshan. A particularly intense erosion process occurred between 1996 and 1998. The major effects on morphological evolution in Jinshan Trough from 1960 to 2011 were investigated and tentative conclusions were presented. Continuous coastal reclamations in Jinshan had the most pronounced effect on the morphological evolution during the first and the second stages. The storm surge had a pronounced effect on the evolution at the beginning of the third stage.

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.

PubMed

Greenall, Sameer A; Bentley, John D; Pearce, Lesley A; Scoble, Judith A; Sparrow, Lindsay G; Bartone, Nicola A; Xiao, Xiaowen; Baxter, Robert C; Cosgrove, Leah J; Adams, Timothy E

2013-01-04

Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I. Its expression in humans is tightly controlled by maternal imprinting, a genetic restraint that is lost in many cancers, resulting in up-regulation of both mature IGF-II mRNA and protein expression. Additionally, increased expression of several longer isoforms of IGF-II, termed "pro" and "big" IGF-II, has been observed. To date, it is ambiguous as to what role these IGF-II isoforms have in initiating and sustaining tumorigenesis and whether they are bioavailable. We have expressed each individual IGF-II isoform in their proper O-glycosylated format and established that all bind to the IGF-I receptor and both insulin receptors A and B, resulting in their activation and subsequent stimulation of fibroblast proliferation. We also confirmed that all isoforms are able to be sequestered into binary complexes with several IGF-binding proteins (IGFBP-2, IGFBP-3, and IGFBP-5). In contrast to this, ternary complex formation with IGFBP-3 or IGFBP-5 and the auxillary protein, acid labile subunit, was severely diminished. Furthermore, big-IGF-II isoforms bound much more weakly to purified ectodomain of the natural IGF-II scavenging receptor, IGF-IIR. IGF-II isoforms thus possess unique biological properties that may enable them to escape normal sequestration avenues and remain bioavailable in vivo to sustain oncogenic signaling.

Magnetic anomaly map of the central Cayman Trough, northwestern Caribbean Sea

USGS Publications Warehouse

Dillon, William P.; Edgar, N. Terence; Parson, Lindsay M.; Scanlon, Kathryn M.; Driscoll, George R.; Jacobs, Colin L.

1993-01-01

This is the first large-scale published map of magnetic anomalies in the central Cayman Trough area. Two previously published very small scale maps based on much less data are a regional map (Gough and Heirtzler, 1969) and a map compiled from several tracklines running parallel to the axis of the Cayman Trough (MacDonald and Holcombe, 1978).

Effect of Channel Catfish Ictalurus Punctatus Egg Mass Loading Rate on Performance of the “See-Saw” Incubator

USDA-ARS?s Scientific Manuscript database

The “See-Saw” is a vertical-lift incubator that increases water circulation around and through channel catfish egg masses. Baskets in the incubator move up and down on racks in conventional hatchery troughs, raising the rack in one trough while lowering the rack in the adjacent trough. Egg masses ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turchi, Craig; Kurup, Parthiv; Akar, Sertac

This study lists material composition data for two concentrating solar power (CSP) plant designs: a molten-salt power tower and a hypothetical parabolic trough plant, both of which employ a molten salt for the heat transfer fluid (HTF) and thermal storage media. The two designs have equivalent generating and thermal energy storage capacities. The material content of the saltHTF trough plant was approximately 25% lower than a comparably sized conventional oil-HTF parabolic trough plant. The significant reduction in oil, salt, metal, and insulation mass by switching to a salt-HTF design is expected to reduce the capital cost and LCOE for themore » parabolic trough system.« less

Cut By Troughs

NASA Technical Reports Server (NTRS)

2005-01-01

1 September 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows an impact crater cut by troughs which formed after the crater formed. The crater and troughs have large windblown ripples on their floors. The ripples, troughs, craters, and other surfaces in this scene have all been mantled by dust. Dark streaks on slopes indicate areas where avalanches of dry dust have occurred. These features are located on Sacra Mena, a large mesa in the Kasei Valles region.

Location near: 25.4oN, 66.8oW Image width: width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Autumn

Aeolian Sediment Transport Pathways and Aerodynamics at Troughs on Mars

NASA Technical Reports Server (NTRS)

Bourke, Mary C.; Bullard, Joanna E.; Barnouin-Jha, Olivier S.

2004-01-01

Interaction between wind regimes and topography can give rise to complex suites of aeolian landforms. This paper considers aeolian sediment associated wit11 troughs on Mars and identifies a wider range of deposit types than has previously been documented. These include wind streaks, falling dunes, "lateral" dunes, barchan dunes, linear dunes, transverse ridges, sand ramps, climbing dunes, sand streamers, and sand patches. The sediment incorporated into these deposits is supplied by wind streaks and ambient Planitia sources as well as originating within the trough itself, notably from the trough walls and floor. There is also transmission of sediment between dneTsh. e flow dynamics which account for the distribution of aeolian sediment have been modeled using two-dimensional computational fluid dynamics. The model predicts flow separation on the upwind side of the trough followed by reattachment and acceleration at the downwind margin. The inferred patterns of sediment transport compare well with the distribution of aeolian forms. Model data indicate an increase of wind velocity by approx. 30 % at the downwind trough margin. This suggests that the threshold wind speed necessary for sand mobilization on Mars will be more freqentmlye t in these inclined locations.

Studies of plasma irregularities and convection in the polar ionosphere using HILAT, SABRE and EISCAT. Interim report, 1 Feb 88-31 Mar 89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, T.B.; Lester, M.; Wilkinson, A.J.

A statistical study of the F-region main ionospheric trough has been undertaken with EISCAT common programme data to assess the possibility that the trough region is a perferential region for the generation of E-region irregularities. Three years of CP-3 data from EISCAT formed the basis of this study. Backscatter observed by the coherent radar, SABRE, was also utilized to study the occurrence of irregularities in the E-region. On 26 out of the 36 days when the trough was observed by EISCAT, SABRE observed coherent backscatter. Although this percentage seems high, there was no consistent relationship between the latitude of themore » trough minimum and the latitude of peak backscatter intensity. A case study involving a four day run of EISCAT in September 1986 indicates that the trough latitude can be affected by changes in the interplanetary magnetic field north-south components. On two days rapid decreases in the latitude of the trough were related to a southward turning of the IMF and the onset of backscatter. The high percentage of occurrence of backscatter is believed to be caused by enhanced convection.« less

Crustal and upper mantle velocity structure of the Salton Trough, southeast California

USGS Publications Warehouse

Parsons, T.; McCarthy, J.

1996-01-01

This paper presents data and modelling results from a crustal and upper mantle wide-angle seismic transect across the Salton Trough region in southeast California. The Salton Trough is a unique part of the Basin and Range province where mid-ocean ridge/transform spreading in the Gulf of California has evolved northward into the continent. In 1992, the U.S. Geological Survey (USGS) conducted the final leg of the Pacific to Arizona Crustal Experiment (PACE). Two perpendicular models of the crust and upper mantle were fit to wide-angle reflection and refraction travel times, seismic amplitudes, and Bouguer gravity anomalies. The first profile crossed the Salton Trough from the southwest to the northeast, and the second was a strike line that paralleled the Salton Sea along its western edge. We found thin crust (???21-22 km thick) beneath the axis of the Salton Trough (Imperial Valley) and locally thicker crust (???27 km) beneath the Chocolate Mountains to the northeast. We modelled a slight thinning of the crust further to the northeast beneath the Colorado River (???24 km) and subsequent thickening beneath the metamorphic core complex belt northeast of the Colorado River. There is a deep, apparently young basin (???5-6 km unmetamorphosed sediments) beneath the Imperial Valley and a shallower (???2-3 km) basin beneath the Colorado River. A regional 6.9-km/s layer (between ???15-km depth and the Moho) underlies the Salton Trough as well as the Chocolate Mountains where it pinches out at the Moho. This lower crustal layer is spatially associated with a low-velocity (7.6-7.7 km/s) upper mantle. We found that our crustal model is locally compatible with the previously suggested notion that the crust of the Salton Trough has formed almost entirely from magmatism in the lower crust and sedimentation in the upper crust. However, we observe an apparently magmatically emplaced lower crust to the northeast, outside of the Salton Trough, and propose that this layer in part predates Salton Trough rifting. It may also in part result from migration of magmatic spreading centers associated with the southern San Andreas fault system. These spreading centers may have existed east of their current locations in the past and may have influenced the lower crust and upper mantle to the east of the current Salton Trough.

Fast flow of Jakobshavn Isbræ and its subglacial drainage system

NASA Astrophysics Data System (ADS)

Werder, M. A.; Joughin, I. R.

2013-12-01

Jakobshavn Isbræ and many other outlet glaciers of present and past ice sheets lie in deep troughs which often have several overdeepened sections. The subglacial drainage system of such glaciers is heavily influenced by two effects caused by the pressure dependence of the melting point of water. The melting point decreases with increasing water pressure, this enhances wall-melt in downward sloping channels and diminishes wall-melt in upward sloping channels. Thus the first effect is the well known shutdown of channels on steep adverse bed slopes of overdeepenings and the associated high water pressure/low effective pressure. The second effect is a 2D effect and has not received much/any attention so far: the orientation of a channel will be deflected from the direction of the (negative) hydraulic potential gradient (which drives the water flow) towards the steepest slope of the bed. This leads to the enhanced formation of side channels dipping into the trough at about a 45° angle. This efficient connection between the margin and the trough equalizes the hydraulic potential, again leading to higher water pressure in the trough. We investigate these two effects with the 2D subglacial drainage system model GlaDS using Jakobshavn Isbræ as an example. We compare model runs with the pressure melt term disabled and enabled. With the term disabled the main channel situated in the trough is continuous and produces a large depression in the hydraulic potential and consequently high effective pressure in the trough (1-2MPa). Conversely, with the term enabled the main channel becomes discontinuous on steep adverse bed slopes and many side channels form on the margins of the trough. This leads to a hydraulic potential in the trough which is higher than in the surrounding area and consequently the effective pressure is low (0-1MPa). Low effective pressure leads to reduced basal drag and thus to more basal sliding. The modeled large decrease of effective pressure in the trough due to the pressure dependence of the melting point of water suggests that basal drag will be small and that sliding speeds are large. Thus, this may be one of the leading causes for the fast flow of Jakobshavn Isbræ and other glaciers in deep troughs.

Simultaneous Sea-Level Oscillations in Japanese Bays Induced by the Tsunami of Nankai-Trough Earthquake

NASA Astrophysics Data System (ADS)

Oishi, Y.; Furumura, T.; Imamura, F.; Yamashita, K.; Sugawara, D.

2016-12-01

In this study, we investigate the response of bays to the tsunami of Nankai-trough earthquake based on tsunami simulations and demonstrate the possibility that sea-level oscillation of each bay, which is induced by an incident tsunami, interacts with those of other bays. Several major cities in Japan, including the capital, are located in the bays near the Nankai trough and it is assumed that these cities will be largely affected by the tsunamis caused by recurring large earthquakes at the trough. Therefore, it is very important for these populated cities to understand the mechanism and properties of the tsunami-induced oscillations that continue for a long time in bays to draw up evacuation plans. To investigate the response of bays for various tsunamis that may occur in the Nankai trough area, we distributed the tsunami sources that have the form of a 2-D Gaussian function around the Nankai trough. From simulations with these sources, it was found that strong oscillations of bay water occur when the source is located in the bay itself or when strong oscillations occur in other bays. For example, when the Tosa bay oscillates, the Tokyo bay that is 600 km away from the Tosa bay also oscillates. Among the bays around the Nankai trough, the Suruga bay, the deepest bay in Japan with a 2500-km depth, oscillates more strongly than other bays for most cases. To check the influence of the strong oscillations in the Suruga bay on other bays, we conducted tsunami simulations using a modified topography model in which the Suruga bay is artificially landfilled. As a consequence, the strength of oscillations in the adjacent bays are reduced by 20-30%, suggesting the large influence of the distinguished oscillation of the Suruga bay on these bays. We finally conducted tsunami simulations using the eleven Nankai-trough earthquake scenarios of the Central Disaster Prevention Council (CDPC) of Japan as tsunami sources, and the mutual relation regarding the strengths of oscillations among the bays around the Nankai trough was confirmed irrespective of the earthquake scenarios. The results of this study suggest that oscillations of the bays do not occur independently in each bay but simultaneously occur among the bays. More detailed characteristics of the response of the bays to the tsunamis in the Nankai-trough area will be discussed in the presentation.

Controls of bioclastic turbidite deposition in eastern Muertos Trough northeast Caribbean Sea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forsthoff, G.M.; Holcombe, T.L.

1985-02-01

A study of seismic-reflection profiles and sediment cores establishes regional bathymetric and source area control over the composition, transport, and distribution of turbidites in the eastern Muertos Trough, Bioclastic (carbonate) turbidites dominate the eastern portion of the trough. Analyses of carbon content and sand-sized components suggest that the bioclastic turbidites (characterized by planktonic foraminifera, pteropods, and sponge spicules) are reworked pelagic oozes originally deposited on the outer-shelf and upper-slope areas south of St. Croix and eastern Puerto Rico. The presence of several intrashelf and upper-slope basins prohibits shallow-water carbonate sediments from entering the Muertos Trough. Volcanic rock fragments derived frommore » Puerto Rico are transported to the trough via the Guayanilla Canyon system. Mixing of the volcanic fragments with outer-shelf and upper-slope lutites results in mixed bioclastic-terrigenous turbidites south of central and western Puerto Rico. The paucity of shallow-water carbonate sediments in the trough suggests that the submarine canyons are effective conduits for the rapid transport of volcaniclastic sands across the shelf and thereby prevent extensive mixing with inner- and middle-shelf carbonate sediments. Sediment transport within the trough is primarily axial in an east-west direction. Outer trench-wall fault scarps, south of Guayanilla Canyon, limit the southerly progradation of the trench-wedge facies and deflect incoming gravity flows in a down-axis (westward) direction. Where no faults exist, the trench wedge progrades southward and interfingers with the pelagic sediments of the northern Venezuelan basin.« less

Weak lensing by galaxy troughs in DES Science Verification data

DOE PAGES

Gruen, D.; Friedrich, O.; Amara, A.; ...

2015-11-29

In this study, we measure the weak lensing shear around galaxy troughs, i.e. the radial alignment of background galaxies relative to underdensities in projections of the foreground galaxy field over a wide range of redshift in Science Verification data from the Dark Energy Survey. Our detection of the shear signal is highly significant (10σ–15σ for the smallest angular scales) for troughs with the redshift range z ϵ [0.2, 0.5] of the projected galaxy field and angular diameters of 10 arcmin…1°. These measurements probe the connection between the galaxy, matter density, and convergence fields. By assuming galaxies are biased tracers ofmore » the matter density with Poissonian noise, we find agreement of our measurements with predictions in a fiducial Λ cold dark matter model. The prediction for the lensing signal on large trough scales is virtually independent of the details of the underlying model for the connection of galaxies and matter. Our comparison of the shear around troughs with that around cylinders with large galaxy counts is consistent with a symmetry between galaxy and matter over- and underdensities. In addition, we measure the two-point angular correlation of troughs with galaxies which, in contrast to the lensing signal, is sensitive to galaxy bias on all scales. The lensing signal of troughs and their clustering with galaxies is therefore a promising probe of the statistical properties of matter underdensities and their connection to the galaxy field.« less

The Nova-Canton Trough and the Late Cretaceous evolution of the central Pacific

NASA Astrophysics Data System (ADS)

Joseph, Devorah; Taylor, Brain; Shor, Alexander N.; Yamazaki, Toshitsugu

Free-air gravity anomalies derived from satellite altimetry data show that the major Pacific fracture zones, from the Pau to Marquesas, are co-polar about an Euler pole located at 150.5°W, 34.6°S for the period preceding chron 33 and including a large portion of the Cretaceous Normal Superchron. They also show continuity of the Clipperton Fracture Zone through the Line Islands to the Nova-Canton ridge and trough; this Canton-Clipperton trend is co-polar to the same pole. Sidescan-sonar and bathymetry data in the Nova-Canton Trough region reveal N140°E-striking abyssal hill topography south of the N70°E-striking structures of the Nova-Canton Trough and crustal fabric striking normal to the trough (N160°E) to the north. We conclude that the Nova-Canton Trough is the Middle Cretaceous extension of the Clipperton Fracture Zone. We propose that the anomalous depths (7000-8400 m) of the trough between 167°30'-168°30'W are the result of a complex plate reorganization. Conjugate magnetic anomaly lineations M1-M3 in the Phoenix lineations between the Central Pacific Fracture Zone and the Phoenix Fracture Zone and the absence of lineations younger than anomaly M3 west of the Phoenix Fracture Zone suggest that spreading may have gradually ceased along the Pacific-Phoenix system from west to east. We infer that the remaining active segment of the Pacific-Phoenix spreading system after anomaly M1 time was the easternmost section of the Phoenix lineations. At ˜M0 time, the Pacific-Phoenix spreading axis stretched from lineated bathymetric depressions lying between 180°W and the Phoenix Islands to ˜168°W and included the western deep of the Nova-Canton Trough. We hypothesize that accretion terminated on the Pacific-Phoenix spreading axis shortly after M0 time and that the absence of an M0 isochron in the region between the eastern Phoenix lineations and the Nova-Canton Trough, or along the Nova-Canton Trough itself, may be due to a decrease in spreading rate prior to termination. We concur with previous hypotheses that portions of the Phoenix plate were trapped on the Pacific plate by a ridge jump south to the nascent Manihiki Plateau; some portions were overprinted by the Aptian volcanism that formed the Manihiki Plateau and Robbie Ridge. Pacific-Farallon spreading south of the Nova-Canton Trough jumped westwards, initiating transcurrent motion along the easternmost section of the failed ˜M0 spreading axis (the western deep of the Nova-Canton Trough) which subsequently became the western end of the Clipperton (Pacific-Farallon) transform. In our reconstruction, the northeast and southeast margins of the Manihiki Plateau are rifted margins that form the western limit of Pacific-Farallon spreading between the Clipperton, Galapagos, and Marquesas fracture zones.

Ocular Penetration and Anti-inflammatory Activity of Ketorolac 0.45% and Bromfenac 0.09% Against Lipopolysaccharide-Induced Inflammation

PubMed Central

Galindo, Danielle; Villanueva, Linda; Nguyen, Cathy; Patel, Milan; Borbridge, Lisa; Attar, Mayssa; Schiffman, Rhett M.; Hollander, David A.

2011-01-01

Abstract Purpose Anti-inflammatory activity of topical nonsteroidal anti-inflammatory drugs is mediated by suppression of cyclooxygenase (COX) isoenzymes. This study compared ocular penetration and inflammation suppression of topical ketorolac 0.45% and bromfenac 0.09% ophthalmic solutions in a rabbit model. Methods At hour 0, 36 rabbits received ketorolac 0.45%, bromfenac 0.09%, or an artificial tear 3 times once every 20 min. Half of the rabbits in each group then received intravenous injections of lipopolysaccharide (LPS) and fluorescein isothiocyanate (FITC)–dextran at hour 1, and the other half at hour 10. Aqueous and iris-ciliary body (ICB) samples were collected in the former group at hour 2 (peak) and in the latter group at hour 11 (trough) An additional group of 6 animals received only FITC-dextran, and samples were collected 1 h later. Peak and trough nonsteroidal anti-inflammatory drug concentrations were compared with previously determined half-maximal inhibitory concentrations (IC50) for COX isoenzymes. Results Peak and trough aqueous and ICB concentrations of ketorolac were at least 7-fold or greater than those of bromfenac. At peak levels, both ketorolac 0.45% and bromfenac 0.09% significantly inhibited LPS-induced aqueous prostaglandin E2 and FITC-dextran elevation (P < 0.01). At trough, both study drugs significantly inhibited LPS-induced aqueous prostaglandin E2 elevation (P < 0.05), but only ketorolac 0.45% significantly reduced LPS-induced aqueous FITC-dextran elevation (P < 0.01). Aqueous and ICB ketorolac concentrations exceeded its IC50 for COX-1 and COX-2 at peak and trough. Aqueous and ICB bromfenac levels exceeded its IC50 for COX-2 at peak and trough, but not for COX-1 at trough aqueous levels and peak and trough ICB levels. Conclusions Both ketorolac 0.45% and bromfenac 0.09% effectively suppressed inflammation at peak. At trough, only ketorolac 0.45% effectively suppressed inflammation as measured by FITC-dextran leakage. The difference in inflammation suppression may be due to differences in tissue concentrations and/or greater COX-1 suppression by ketorolac 0.45%. PMID:21351868

Interactions of poly(tert-butyl acrylate)-poly(styrene) diblock copolymers with lipids at the air-water interface.

PubMed

Mudgil, Poonam; Dennis, Gary R; Millar, Thomas J

2006-08-29

Diblock copolymers with hydrophilic poly(tert-butyl acrylate) (PtBA) and hydrophobic poly(styrene) (PS) blocks were synthesized with a view to use them as a surfactant in tear film for increasing the ocular comfort in dry eye syndrome. Interactions of six PtBA-PS copolymers with four important lipids found in the tear film, namely cholesterol, cholesteryl palmitate, dipalmitoyl phosphatidylcholine, and phosphatidylinositol, were studied at the air-water interface using a Langmuir trough. Thermodynamics of mixing of the copolymers and the lipids in the mixed monolayers was determined by calculating excess free energy of mixing. The diblock copolymers showed repulsive interactions with cholesteol and cholesteryl palmitate, near neutral interactions with dipalmitoyl phosphatidylcholine, and attractive interactions with phosphatidylinositol. The lipids interacted with the PS component of the copolymer. The results indicate that a copolymer with a small hydrophilic group and a big hydrophobic group can be a likely candidate for forming stable interactions with the lipids present in the tear film and hence increase the ocular comfort.

Associative nature of event participation dynamics: A network theory approach

PubMed Central

Smiljanić, Jelena; Mitrović Dankulov, Marija

2017-01-01

The affiliation with various social groups can be a critical factor when it comes to quality of life of each individual, making such groups an essential element of every society. The group dynamics, longevity and effectiveness strongly depend on group’s ability to attract new members and keep them engaged in group activities. It was shown that high heterogeneity of scientist’s engagement in conference activities of the specific scientific community depends on the balance between the numbers of previous attendances and non-attendances and is directly related to scientist’s association with that community. Here we show that the same holds for leisure groups of the Meetup website and further quantify individual members’ association with the group. We examine how structure of personal social networks is evolving with the event attendance. Our results show that member’s increasing engagement in the group activities is primarily associated with the strengthening of already existing ties and increase in the bonding social capital. We also show that Meetup social networks mostly grow trough big events, while small events contribute to the groups cohesiveness. PMID:28166305

Facies mosaic in a fiord: Carboniferous-Permian Talchir Formation, India

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bose, P.K.; Mukhopadhyay, G.; Bhattacharya, H.N.

1988-01-01

Facies analysis of the basal 37m of the Carboniferous-Permian Talchir Formation is a glacier-fed bedrock trough in Dudhi nala, Bihar, India, provides insight into the pattern of sedimentation of course gravels in a fiord. Rapid transitions between 11 recognized facies, together with their complex organization, random variability in bed thickness, and differences in clast, shape, size, and composition indicate coalescence of fans developed from numerous point sources bordering the elongated trough. Converging slide masses and lodgment tillites on the slopes flanking the trough give way to sediment gravity flow deposits composed of an array of conglomerates (matrix and clast supportedmore » with normal, inverse of absence of grading), attendant turbidite sands, and prodelta mud. The rheology of the in-trough flows ranged from plastic laminar to fluidal turbulent in response to flow from slope to floor of the trough. Rapid calving of icebergs during the onset of deglaciation established a wave regime at the mouth of the trough and deposited cross-stratified sandstone replete with dripstones. The impact of large dripstones landing triggered turbidity currents. Continued rise in water level led to eventual preservation of the fan complex under onlapping wave-built shoal facies that grade into a sequence of upward-thinning hummocky cross-stratified sandstone beds virtually devoid of dripstones.« less

Altitude Variation of the Plasmapause Signature in the Main Ionospheric Trough

NASA Technical Reports Server (NTRS)

Grebowsky, Joseph M.; Benson, Robert F.; Webb, Phillip A.; Truhlik, Vladimir; Bilitza, Dieter

2009-01-01

The projection of the plasmapause magnetic-field lines to low altitudes, where the light-ion chemistry is dominated by O(+), tends to occur near the minimum electron density in the main (midlatitude) electron density trough at night. With increasing attitude in the trough, where H(+) emerges as the dominant iota on the low-latitude boundary, we have found cases where the plasmapause field lines are located on the sharp low-Latitude side of the trough as expected if this topside ionosphere H(+) distribution varies in step with the plasmapause gradient in the distant plasmasphere. These conclusions are based on near-equatorial crossings of the plasmapause (corresponding to the steep gradient in the dominant species H(+) by the Explorer-45 satellite as determined from electric-field measurements by Maynard and Cauffman in the early 1970s and ISIS-2 ionospheric topside-sounder measurements. The former data have now been converted to digital form and made available at http://nssdcftp.gsfc.nasa.gov. The latter provide samples of nearly coincident observations of ionospheric main trough crossings near the same magnetic-field lines of the Explorer 45-determined equatorial plasmapause. The ISIS-2 vertical electron density profiles are used to infer where the F-region transitions from an O(+) to a H(+) dominated plasma through the main trough boundaries.

Climatology of the winter Red Sea Trough

NASA Astrophysics Data System (ADS)

Awad, Adel M.; Almazroui, Mansour

2016-12-01

In this study, a new and objective method for detecting the Red Sea Trough (RST) was developed using mean sea level pressure (SLP) data from NCEP/NCAR reanalysis dataset from the winters of 1956 to 2015 to identify the Sudan Low and its trough. Approximately 96% of the winter RSTs were generated near two main sources, South Sudan and southeastern Sudan, and approximately 85% of these troughs were in four of the most outer areas surrounding the northern Red Sea. Moreover, from west to east of the Red Sea, the RST was affected by the relationships between the Siberian High and Azores High. The RST was oriented to the west when the strength of the Siberian High increased and to the east when the strength of the Azores High increased. Furthermore, the synoptic features of the upper level of the RST emphasize the impacts of subtropical anticyclones at 850 hPa on the orientation of the RST, the impacts of the northern cyclone trough and the maximum wind at a pressure level of 250 hPa. The average static stability between 1000 hPa and 500 hPa demonstrated that the RST followed the northern areas of low static stability. The results from previous studies were confirmed by a detailed case study of the RST that extended to its central outermost area. The results of a detailed case study of the short RST indicated that the trough becomes shorter with increasing static stability and that the Azores and Siberian high-pressure systems influence the northern region of the trough while the maximum upper wind shifts south of the climate position.

Use of rapid prototyping drill template for the expansive open door laminoplasty: A cadaveric study.

PubMed

Rong, Xin; Wang, Beiyu; Chen, Hua; Ding, Chen; Deng, Yuxiao; Ma, Lipeng; Ma, Yanzhao; Liu, Hao

2016-11-01

Trough preparation is a technically demanding yet critical procedure for successful expansive open door laminoplasty (EOLP), requiring both proper position and appropriate bone removal. We aimed to use the specific rapid prototyping drill template to achieve such requirement. The 3D model of the cadaveric cervical spine was reconstructed using the Mimics 17.0 and Geomagic Studio 12.0 software. The drilling template was designed in the 3-Matic software. The trough position was simulated at the medial margin of the facet joint. Two holders were designed on both sides. On the open side, the holder would just allow the drill penetrate the ventral cortex of the lamina. On the hinge side, the holder was designed to keep the ventral cortex of the lamina intact. One orthopedic resident performed the surgery using the rapid prototyping drill template on four cadavers (template group). A control group of four cadavers were operated upon without the use of the template. The deviation of the final trough position from the simulated trough position was 0.18mm±0.51mm in the template group. All the troughs in the template group and 40% of the troughs in the control group were at the medial side of the facet joint. The complete hinge fracture rate was 5% in the template group, significantly lower than that (55%) in the control group (P=0.01). The rapid prototyping drill template could help the surgeon accomplish proper trough position and appropriate bone removal in EOLP on the cadaveric cervical spine. Copyright © 2016 Elsevier B.V. All rights reserved.

Petroleum prospects of Benue trough, Nigeria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nawachukwu, J.I.

1985-04-01

Exploration activities in the Benue trough have been minimal over the years, mainly because of large petroleum deposits found in the adjoining Niger delta and early gas finds in the Anambra basin, south of the Benue trough. The recent increase in exploration activities in the trough has necessitated a reevaluation of the petroleum potentials of the basin. In this study, the time-temperature index (TTI) method was used to evaluate petroleum prospects of the basin. An increase in geothermal gradient resulted in a decrease in depth to the oil window, with the sediments maturing earlier at higher geothermal gradients. At geothermalmore » gradients of 1.5-1.9/sup 0/F/100 ft (2.73.5/sup 0/C/100 m) and maximum TTI values, the Asu River Group and the Eze-Aku Group of sediments are still within the gas-generating stage. The Awgu Shale and the Nkporo Shale are capable of generating gas at geothermal gradients of 2.3-2.7/sup 0/F/100 ft (4.2-4.9/sup 0/C/100 m). The Benue trough is essentially a gas-condensate basin with little oil. Exploration targets in the basin include both the sub-Santonian and superSantonian sediments, with the Eze-Aku Group, Awgu Shale, and Nkporo Shale being more prospective than the stratigraphically lower Asu River Group. In general, the middle Benue trough is considered to be the most prospective area within the trough because depths to the mature zones are moderate (6,600-13,000 ft; 2-4 km). These depths are variable, decreasing northeastward and increasing southwestward toward the Niger delta.« less

Katabatic jumps in the Martian northern polar regions

NASA Astrophysics Data System (ADS)

Spiga, Aymeric; Smith, Isaac

2018-07-01

Martian polar regions host active regional wind circulations, such as the downslope katabatic winds which develop owing to near-surface radiative cooling and sloped topography. Many observations (stratigraphy from radar profiling, frost streaks, spectral analysis of ices) concur to show that aeolian processes play a key role in glacial processes in Martian polar regions. A spectacular manifestation of this resides in elongated clouds that forms within the polar spiral troughs, a series of geological depressions in Mars' polar caps. Here we report mesoscale atmospheric modeling in Martian polar regions making use of five nested domains operating a model downscaling from horizontal resolutions of twenty kilometers to 200 m in a typical polar trough. We show that strong katabatic jumps form at the bottom of polar troughs with an horizontal morphology and location similar to trough clouds, large vertical velocity (up to +3 m/s) and temperature perturbations (up to 20 K) propitious to cloud formation. This strongly suggests that trough clouds on Mars are caused by katabatic jumps forming within polar troughs. This phenomena is analogous to the terrestrial Loewe phenomena over Antarctica's slopes and coastlines, resulting in a distinctive "wall of snow" during katabatic events. Our mesoscale modeling results thereby suggest that trough clouds might be present manifestations of the ice migration processes that yielded the internal cap structure discovered by radar observations, as part of a "cyclic step" process. This has important implications for the stability and possible migration over geological timescales of water ice surface reservoirs-and, overall, for the evolution of Mars' polar caps over geological timescales.

Laboratory measurement of apixaban using anti-factor Xa assays in acute ischemic stroke patients with non-valvular atrial fibrillation.

PubMed

Shin, Hyoshim; Cho, Min-Chul; Kim, Rock Bum; Kim, Chang-Hun; Choi, Nack-Cheon; Kim, Soo-Kyung; Koh, Eun-Ha

2018-02-01

Apixaban is effective and safe for preventing stroke, and its usage has increased exponentially in recent years. However, data concerning the therapeutic range of apixaban is limited. This study determined the trough and peak levels of apixaban-specific anti-factor Xa activity (AFXaA) in acute ischemic stroke patients with non-valvular atrial fibrillation (NVAF) in Korea. The study included 85 patients who received apixaban. Blood samples were taken to measure the trough and peak levels of AFXaA using a chromogenic anti-factor assay, as well as prothrombin time (PT) and activated partial thromboplastin time (aPTT). We also reviewed complications such as major bleeding of patients treated with apixaban. In patients given a 5.0-mg apixaban dose, the median trough and peak levels of AFXaA were 104.5 and 202.0 ng/mL. In patients given a 2.5-mg apixaban dose, the median trough and peak AFXaA levels were 76.0 and 151.0 ng/mL. The PT showed a positive correlation with increased AFXaA activity at both levels (Trough R = 0.486, Peak R = 0.592), but the aPTT had no relationship with AFXaA activity at both levels (Trough R = 0.181, Peak R = 0.129). Two cases with intracranial bleeding belonged to the highest AFXaA quartile (Trough, p = 0.176; Peak, p = 0.053). In conclusion, we determined the trough and peak levels of AFXaA in patients with NVAF while being treated with the apixaban in Korea. Our results could be used as a starting point when setting the reference ranges for laboratories using anti-Xa assay. Large-scale studies are needed to establish the reference range for AFXaA in patients with NVAF.

Early vedolizumab trough levels predict mucosal healing in inflammatory bowel disease: a multicentre prospective observational study.

PubMed

Yacoub, W; Williet, N; Pouillon, L; Di-Bernado, T; De Carvalho Bittencourt, M; Nancey, S; Lopez, A; Paul, S; Zallot, C; Roblin, X; Peyrin-Biroulet, L

2018-04-01

The correlation between vedolizumab trough levels during induction therapy and mucosal healing remains unknown. To compare early vedolizumab trough levels in patients with and without mucosal healing within the first year after treatment initiation. We prospectively collected vedolizumab trough levels in all inflammatory bowel disease patients at weeks 2, 6 and 14 of vedolizumab treatment in three French referral centres between 1 June 2014 and 31 March 2017. Results of every patient that underwent mucosal assessment by magnetic resonance imaging and/or endoscopy in the first year after treatment initiation were analysed. Median vedolizumab trough levels in the overall population (n = 82) were 27 μg/mL (interquartile range, IQR 21.2-33.8 μg/mL) at week 2, 23 μg/mL (IQR 15-34.5 μg/mL) at week 6 and 10.7 μg/mL (IQR 4.6-20.4 μg/mL) at week 14. Only median vedolizumab trough levels at week 6 differed between patients with and without mucosal healing within the first year after treatment initiation (26.8 vs 15.1 μg/mL, P = 0.035). A cut-off trough level of 18 μg/mL at week 6 predicted mucosal healing within the first year after the start of vedolizumab with an area under the receiver operating curve of 0.735 (95% confidence interval 0.531-0.939). A vedolizumab trough level above 18 μg/mL at week 6 was the only independent variable associated with mucosal healing within the first year of treatment (odds ratio 15.7, 95% confidence interval 2.4-173.0, P = 0.01). Early therapeutic drug monitoring might improve timely detection of vedolizumab-treated patients in need for an intensified dosing regimen. © 2018 John Wiley & Sons Ltd.

Mass Balance Changes and Ice Dynamics of Greenland and Antarctic Ice Sheets from Laser Altimetry

NASA Astrophysics Data System (ADS)

Babonis, G. S.; Csatho, B.; Schenk, T.

2016-06-01

During the past few decades the Greenland and Antarctic ice sheets have lost ice at accelerating rates, caused by increasing surface temperature. The melting of the two big ice sheets has a big impact on global sea level rise. If the ice sheets would melt down entirely, the sea level would rise more than 60 m. Even a much smaller rise would cause dramatic damage along coastal regions. In this paper we report about a major upgrade of surface elevation changes derived from laser altimetry data, acquired by NASA's Ice, Cloud and land Elevation Satellite mission (ICESat) and airborne laser campaigns, such as Airborne Topographic Mapper (ATM) and Land, Vegetation and Ice Sensor (LVIS). For detecting changes in ice sheet elevations we have developed the Surface Elevation Reconstruction And Change detection (SERAC) method. It computes elevation changes of small surface patches by keeping the surface shape constant and considering the absolute values as surface elevations. We report about important upgrades of earlier results, for example the inclusion of local ice caps and the temporal extension from 1993 to 2014 for the Greenland Ice Sheet and for a comprehensive reconstruction of ice thickness and mass changes for the Antarctic Ice Sheets.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardenas, A.; Lewinsohn, J.; Auger, C.

The Hanford Site contains one of the few remaining contiguous areas of shrub-steppe habitat left in Washington State. This habitat is home to many native plant and wildlife species, some of which are threatened with extinction or are unique to the Site. The importance of the Hanford Site increases as other lands surrounding the Site are developed, and these native species and habitats are lost. Stands of Wyoming big sagebrush (Artemisia tridentata ssp. wyomingensis) on the Site are a particularly important component of shrub-steppe habitat, because a number of wildlife require big sagebrush for food and cover. Since 1993, researchersmore » and field biologists have made anecdotal observations of dying and declining sagebrush in stands of shrubs near the 100 Areas. This study was initiated to delineate and document the general boundary where sagebrush stands appear to be declining. We mapped the areal extent of the die-off using a global positioning system and found that the central portion of the die-off encompasses 280 hectares. Shrub stand defoliation was estimated to be near or greater than 80% in this area. The remainder of the die-off area exhibits varying mixtures of completely defoliated, partially defoliated, and healthy-looking stands. Declining sagebrush stands comprise a total of 1776 hectares.« less

Making sense of big data in health research: Towards an EU action plan.

PubMed

Auffray, Charles; Balling, Rudi; Barroso, Inês; Bencze, László; Benson, Mikael; Bergeron, Jay; Bernal-Delgado, Enrique; Blomberg, Niklas; Bock, Christoph; Conesa, Ana; Del Signore, Susanna; Delogne, Christophe; Devilee, Peter; Di Meglio, Alberto; Eijkemans, Marinus; Flicek, Paul; Graf, Norbert; Grimm, Vera; Guchelaar, Henk-Jan; Guo, Yi-Ke; Gut, Ivo Glynne; Hanbury, Allan; Hanif, Shahid; Hilgers, Ralf-Dieter; Honrado, Ángel; Hose, D Rod; Houwing-Duistermaat, Jeanine; Hubbard, Tim; Janacek, Sophie Helen; Karanikas, Haralampos; Kievits, Tim; Kohler, Manfred; Kremer, Andreas; Lanfear, Jerry; Lengauer, Thomas; Maes, Edith; Meert, Theo; Müller, Werner; Nickel, Dörthe; Oledzki, Peter; Pedersen, Bertrand; Petkovic, Milan; Pliakos, Konstantinos; Rattray, Magnus; I Màs, Josep Redón; Schneider, Reinhard; Sengstag, Thierry; Serra-Picamal, Xavier; Spek, Wouter; Vaas, Lea A I; van Batenburg, Okker; Vandelaer, Marc; Varnai, Peter; Villoslada, Pablo; Vizcaíno, Juan Antonio; Wubbe, John Peter Mary; Zanetti, Gianluigi

2016-06-23

Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health and healthcare for all Europeans.

Evidence and mechanism of Hurricane Fran-Induced ocean cooling in the Charleston Trough

NASA Astrophysics Data System (ADS)

Xie, Lian; Pietrafesa, L. J.; Bohm, E.; Zhang, C.; Li, X.

Evidence of enhanced sea surface cooling during and following the passage of Hurricane Fran in September 1996 over an oceanic depression located on the ocean margin offshore of Charleston, South Carolina (referred to as the Charleston Trough), [Pietrafesa, 1983] is documented. Approximately 4C° of sea surface temperature (SST) reduction within the Charleston Trough following the passage of Hurricane Fran was estimated based on SST imagery from Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-14 polar orbiting satellite. Simulations using a three-dimensional coastal ocean model indicate that the largest SST reduction occurred within the Charleston Trough. This SST reduction can be explained by oceanic mixing due to storm-induced internal inertia-gravity waves.

Adsorption of apo- and holo-tear lipocalin to a bovine Meibomian lipid film.

PubMed

Mudgil, Poonam; Millar, Thomas J

2008-04-01

Adsorption of apo- and holo-tear lipocalin (Tlc) to bovine Meibomian lipid film was studied. A Langmuir trough was used for these studies and the adsorption of protein was observed by recording changes in the pressure with time (pi-T profile). The films were photographed at different stages of adsorption by doping Meibomian lipids with a fluorescently tagged lipid. The results indicated that apo-Tlc adsorbed much more quickly than holo-Tlc to the Meibomian lipid film. Contrary to the expectation that holo-Tlc would release lipids to the surface and surface pressure would be higher, it was found that the surface pressure was higher with the adsorption of apo-Tlc to the surface. Photography of the films showed that apo- and holo-Tlc interacted differently with the Meibomian lipid layer. Adsorption of holo-Tlc resulted in big bright patches and adsorption of apo-Tlc resulted in many small patches along with the big patches. Both forms of Tlc produced a more stable film as indicated by decreased movement of the protein adsorbed films, and a higher maximum surface pressure upon compression of these films compared with Meibomian lipid films alone. Isocyles of apo-Tlc adsorbed films gave a higher surface pressure than that of holo-Tlc. From these results, it is concluded that both apo- and holo-Tlc adsorbed to the Meibomian lipid layer and the delivery of the lipids from Tlc to the outer lipid layer could not be detected by our techniques. Its scavenging role to remove lipids from the corneal surface and bind with them might be beneficial for increasing tear viscosity but whether those lipids are delivered to the outermost lipid layer still remains unclear.

Stratigraphic, sedimentologic, and dendrogeomorphic analyses of rapid floodplain formation along the Rio Grande in Big Bend National Park, Texas

USGS Publications Warehouse

Dean, D.J.; Scott, M.L.; Shafroth, P.B.; Schmidt, J.C.

2011-01-01

The channel of the lower Rio Grande in the Big Bend region rapidly narrows during years of low mean and peak flow. We conducted stratigraphic, sedimentologic, and dendrogeomorphic analyses within two long floodplain trenches to precisely reconstruct the timing and processes of recent floodplain formation. We show that the channel of the Rio Grande narrowed through the oblique and vertical accretion of inset floodplains following channel-widening floods in 1978 and 1990-1991. Vertical accretion occurred at high rates, ranging from 16 to 35 cm/yr. Dendrogeomorphic analyses show that the onset of channel narrowing occurred during low-flow years when channel bars obliquely and vertically accreted fine sediment. This initial stage of accretion occurred by both bedload and suspended-load deposition within the active channel. Vegetation became established on top of these fine-grained deposits during years of low peak flow and stabilized these developing surfaces. Subsequent deposition by moderate floods (between 1.5 and 7 yr recurrence intervals) caused additional accretion at rapid rates. Suspended-sediment deposition was dominant in the upper deposits, resulting in the formation of natural levees at the channel margins and the deposition of horizontally bedded, fining-upward deposits in the floodplain trough. Overall, channel narrowing and floodplain formation occurred through an evolution from active-channel to floodplain depositional processes. High-resolution dendrogeomorphic analyses provide the ability to specifically correlate the flow record to the onset of narrowing, the establishment of riparian vegetation, the formation of natural levees, and ultimately, the conversion of portions of the active channel to floodplains. ?? 2011 Geological Society of America.

Plutonium activities and 240Pu/ 239Pu atom ratios in sediment cores from the east China sea and Okinawa Trough: Sources and inventories

NASA Astrophysics Data System (ADS)

Wang, Zhong-liang; Yamada, Masatoshi

2005-05-01

Plutonium concentrations and 240Pu/ 239Pu atom ratios in the East China Sea and Okinawa Trough sediment cores were determined by isotope dilution inductively coupled plasma mass spectrometry after separation using ion-exchange chromatography. The results showed that 240Pu/ 239Pu atom ratios in the East China Sea and Okinawa Trough sediments, ranging from 0.21 to 0.33, were much higher than the reported value of global fallout (0.18). The highest 240Pu/ 239Pu ratios (0.32-0.33) were observed in the deepest Okinawa Trough sediment samples. These ratios suggested the US nuclear weapons tests in the early 1950s at the Pacific Proving Grounds in the Marshall Islands were a major source of plutonium in the East China Sea and Okinawa Trough sediments, in addition to the global fallout source. It was proposed that close-in fallout plutonium was delivered from the Pacific Proving Grounds test sites via early direct tropospheric fallout and transportation by the North Pacific Equatorial Circulation system and Kuroshio Current into the Okinawa Trough and East China Sea. The total 239 + 240 Pu inventories in the cores were about 150-200% of that expected from direct global fallout; about 46-67% of the total inventories were delivered from the Pacific Proving Grounds. Much higher 239 + 240 Pu inventories were observed in the East China Sea sediments than in sediments of the Okinawa Trough, because in the open oceans, part of the 239 + 240 Pu was still retained in the water column, and continued Pu scavenging was higher over the margin than the trough. According to the vertical distributions of 239 + 240 Pu activities and 240Pu/ 239Pu atom ratios in these cores, it was concluded that sediment mixing was the dominant process in controlling profiles of plutonium in this area. Faster mixing in the coastal samples has homogenized the entire 240Pu/ 239Pu ratio record today; slightly slower mixing and less scavenging in the Okinawa Trough have left the surface sediment ratios closer to the modern North Pacific water end member and higher ratios (0.30-0.34) at the bottom of the cores.

Waveform anomaly caused by strong attenuation in the crust and upper mantle in the Okinawa Trough region

NASA Astrophysics Data System (ADS)

Padhy, S.; Furumura, T.; Maeda, T.

2017-12-01

The Okinawa Trough is a young continental back-arc basin located behind the Ryukyu subduction zone in southwestern Japan, where the Philippine Sea Plate dives beneath the trough, resulting in localized mantle upwelling and crustal thinning of the overriding Eurasian Plate. The attenuation structure of the plates and surrounding mantle in this region associated with such complex tectonic environment are poorly documented. Here we present seismological evidence for these features based on the high-resolution waveform analyses and 3D finite difference method (FDM) simulation. We analyzed regional broadband waveforms recorded by F-net (NIED) of in-slab events (M>4, H>100 km). Using band-passed (0.5-8 Hz), mean-squared envelopes, we parameterized coda-decay in terms of rise-time (time from P-arrival to maximum amplitude in P-coda), decay-time (time from maximum amplitude to theoretical S-arrival), and energy-ratio defined as the ratio of energy in P-coda to that in direct P wave. The following key features are observed. First, there is a striking difference in S-excitation along paths traversing and not traversing the trough: events from SW Japan not crossing the trough show clear S waves, while those occurring in the trough show very weak S waves at a station close to the volcanic front. Second, some trough events exhibit spindle-shaped seismograms with strong P-coda excitation, obscuring the development of S waves, at back-arc stations; these waveforms are characterized by high decay-time (>10s) and high energy-ratio (>>1.0), suggesting strong forward scattering along ray paths. Third, some trough events show weak S-excitation characterized by low decay-time (<5s) and low energy-ratio (<1.0) at fore-arc stations, suggesting high intrinsic absorption. To investigate the mechanism of the observed anomalies, we will conduct FDM simulation for a suite of models comprising the key subduction features like localized mantle-upwelling and crustal thinning expected in the region. It is expected that simulation results help to resolve rift-induced crust and upper mantle anomalies in the trough showing maximum waveform distortion as we observed in broadband records, and will enhance understanding of tectonic processes related to back-arc rifting in the region.

Andromeda's SMBH Projected Accretion Rate

NASA Astrophysics Data System (ADS)

Wilson, John

2014-03-01

A formula for calculating the half-life of galaxy clusters is proposed. A galactic half-life is the estimated amount of time that the most massive supermassive black hole (SMBH) in the galaxy cluster will have accreted one half of the mass in the cluster. The calculation is based on a projection of the SMBH continuing its exponentially decreasing rate of accretion that it had in its first 13 billion years. The calculated half-life for the Andromeda SMBH is approximately 1.4327e14 years from the Big Bang. Several proposals have suggested that black holes could be significant factors in the formation of new universes. Part of the verification or falsification of this hypothesis could be done by an N-body simulation. These simulations require an enormous amount of computer power and time. Some plausible projection of the growth of the supermassive black hole is needed to prepare an N-body simulation budget proposal. For now, this method provides an estimate for the growth rate of the Andromeda SMBH and deposition of the outcome of most of the galaxy cluster's mass which is either accreted by the SMBH, lost by ejection from the cluster, or lost in the form of energy.

Can we avoid the Sixth Mass Extinction? Setting today's extinction crisis in the context of the Big Five

NASA Astrophysics Data System (ADS)

Barnosky, A. D.

2012-12-01

While the ultimate extinction driver now—Homo sapiens—is unique with respect to the drivers of past extinctions, comparison of parallel neontological and paleontological information helps calibrate how far the so-called Sixth Mass Extinction has progressed and whether it is inevitable. Such comparisons document that rates of extinction today are approaching or exceeding those that characterized the Big Five Mass Extinctions. Continuation of present extinction rates for vertebrates, for example, would result in 75% species loss—the minimum benchmark exhibited in the Big Five extinctions—within 3 to 22 centuries, assuming constant rates of loss and no threshold effects. Preceding and during each of the Big Five, the global ecosystem experienced major changes in climate, atmospheric chemisty, and ocean chemistry—not unlike what is being observed presently. Nevertheless, only 1-2% of well-assessed modern species have been lost over the past five centuries, still far below what characterized past mass extinctions in the strict paleontological sense. For mammals, adding in the end-Pleistocene species that died out would increase the species-loss percentage by some 5%. If threatened vertebrate species were to actually go extinct, losses would rise to between 14 and 40%, depending on the group. Such observations highlight that, although many species have already had their populations drastically reduced to near-critical levels, the Sixth Mass Extinction has not yet progressed to the point where it is unavoidable. Put another way, the vast majority of species that have occupied the world in concert with Homo sapiens are still alive and are possible to save. That task, however, will require slowing the abnormally high extinction rates that are now in progress, which in turn requires unified efforts to cap human population growth, decrease the average human footprint, reduce fossil fuel use while simultaneously increasing clean energy technologies, integrate valuation of natural capital into economic systems, and rescue species from impacts of inevitable climate change.

Experimental feeding of DDE and PCB to female big brown bats (Eptesicus fuscus)

USGS Publications Warehouse

Clark, D.R.; Prouty, R.M.

1977-01-01

Twenty-two female big brown bats (Eptesicus fuscus) were collected in a house attic in Montgomery County, Maryland. Seventeen were fed mealworms (Tenebrio molitor larvae) that contained 166 ppm DDE; the other five were fed uncontaminated mealworms. After 54 days of feeding, six dosed bats were frozen and the remaining 16 were starved to death. In a second experiment, 21 female big brown bats were collected in a house attic in Prince Georges County, Maryland. Sixteen were fed mealworms that contained 9.4 ppm Aroclor 1254 (PCB). After 37 days, two bats had died, four dosed bats were frozen, and the remaining 15 were starved to death. Starvation caused mobilization of stored residues. After the feeding periods, average weights of all four groups (DDE-dosed, DDE control, PCB-dosed, PCB control) had increased. However, weights of DDE-dosed bats had increased significantly more than those of their contols, whereas weights of PCB-dosed bats had increased significantly less than those of their controls. During starvation, PCB-dosed bats lost weight significantly more slowly than controls. Because PCB levels in dosed bats resembled levels found in some free-living big brown bats, PCBs may be slowing metabolic rates of some free-living bats. It is not known how various common organochlorine residues may affect metabolism in hibernating bats. DDE and PCB increased in brains of starving bats as carcass fat was metabolized. Because the tremors and/or convulsions characteristic of neurotoxicity were not observed, we think even the maximum brain levels attained (132 ppm DDE, 20 ppm PCB) were sublethal. However, extrapolation of our DDE data predicted lethal brain levels when fat reserves declined sufficiently. PCB-dosed bats were probably in no danger of neurotoxic poisoning. However, PCB can kill by a nonneurotoxic mode, and this could explain the deaths of two bats on PCB dosage.

Plasma trough concentrations of darunavir/ritonavir and raltegravir in older patients with HIV-1 infection.

PubMed

Calza, L; Colangeli, V; Magistrelli, E; Bussini, L; Conti, M; Ramazzotti, E; Mancini, R; Viale, P

2017-08-01

The aim of the study was to assess plasma concentrations of darunavir/ritonavir and raltegravir in older patients compared with younger patients with HIV-1 infection. In this observational, open-label study, adult HIV-infected out-patients aged ≤ 40 years (younger patients) or ≥ 60 years (older patients) and treated with tenofovir/emtricitabine plus darunavir/ritonavir (800/100 mg daily) or raltegravir (400 mg twice daily) were asked to participate. The trough concentrations (C trough ) of darunavir/ritonavir and raltegravir were assessed at steady state using a validated high-performance liquid chromatography (HPLC)-tandem mass spectrometry method. A total of 88 HIV-positive patients were enrolled in the study. Forty-six patients were treated with darunavir/ritonavir, and 42 with raltegravir. The geometric mean plasma C trough (coefficient of variation) of raltegravir was comparable between the 19 older and 23 younger subjects: 106 ng/mL (151%) and 94 ng/mL (129%), respectively [geometric mean ratio (GMR) 0.85; 95% confidence interval (CI) 0.71-1.57; P = 0.087]. In contrast, the geometric mean plasma C trough of darunavir was significantly higher among the 21 older patients [2209 ng/mL (139%)] than among the 25 younger patients [1876 ng/mL (162%); GMR 1.56; 95% CI: 1.22-1.88; P = 0.004]. Similarly, the geometric mean C trough of ritonavir was significantly higher among older than among younger individuals. The mean plasma C trough of darunavir and ritonavir was significantly higher in older patients than in younger patients with HIV-1 infection, while the mean plasma level of raltegravir was comparable in the two groups. However, both regimens showed good tolerability in both younger and older subjects. © 2017 British HIV Association.

Healthcare-associated Staphylococcus aureus bacteremia in children: Evidence for reverse vancomycin creep and impact of vancomycin trough levels on outcome

PubMed Central

McNeil, J Chase; Kok, Eric Y; Forbes, Andrea; Lamberth, Linda; Hulten, Kristina G; Vallejo, Jesus G; Mason, Edward O; Kaplan, Sheldon L

2015-01-01

Introduction Elevated vancomycin MICs in S. aureus have been associated with worse clinical outcomes in adults. For invasive MRSA infections in adults, the IDSA recommends targeting vancomycin serum trough concentrations between 15–20 μg/ml. We evaluated trends in vancomycin MICs from healthcare-associated S. aureus bacteremia isolates in children in addition to correlating vancomycin serum trough levels with clinical outcomes. Methods Patients and isolates were identified from a prospective S. aureus surveillance study at Texas Children's Hospital (TCH). Healthcare-associated S. aureus bacteremia isolates from 2003–2013 were selected. Vancomycin MICs by E-test were determined and medical records were reviewed. Acute kidney injury (AKI) was defined as doubling of the baseline serum creatinine. Results 341 isolates met inclusion criteria. We observed a reverse vancomycin creep among MRSA isolates in the study period with a decline in the proportion of isolates with vancomycin MIC ≥ 2 μg/ml (from 32.7% to 5.6%, p<0.001). However, the proportion of MSSA isolates with MIC ≥ 2 μg/ml increased (from 2.9% to 9%, p=0.04). Among patients who had vancomycin troughs performed, there was no difference in duration of bacteremia or fever with vancomycin trough >15 μg/ml vs. < 15 μg/ml. A vancomycin trough > 15 μg/ml was, however, an independent risk factor for AKI. Conclusions Vancomycin MICs are shifting among healthcare-associated S. aureus bacteremia isolates with significant differences between MRSA and MSSA at TCH. Higher vancomycin troughs did not improve outcomes in pediatric healthcare-associated S. aureus bacteremia but were associated with increased nephrotoxicity. Further studies are needed to better understand optimal management of children with S. aureus bacteremia. PMID:26646549

Habitat use by larval fishes in a temperate South African surf zone

NASA Astrophysics Data System (ADS)

Watt-Pringle, Peter; Strydom, Nadine A.

2003-12-01

Larval fishes were sampled in the Kwaaihoek surf zone on the south east coast of South Africa. On six occasions between February and May 2002, larval fishes were collected in two habitat types identified in the inner surf zone using a modified beach-seine net. The surf zone habitats were classified as either sheltered trough areas or adjacent exposed surf areas. Temperature, depth and current measurements were taken at all sites. Trough habitats consisted of a depression in surf topography characterised by reduced current velocities and greater average depth than adjacent surf areas. In total, 325 larval fishes were collected. Of these, 229 were collected in trough and 96 in surf habitats. At least 22 families and 37 species were represented in the catch. Dominant families were the Mugilidae, Sparidae, Atherinidae, and Engraulidae. Dominant species included Liza tricuspidens and Liza richardsonii (Mugilidae), Rhabdosargus holubi and Sarpa salpa (Sparidae), Atherina breviceps (Atherinidae) and Engraulis japonicus (Engraulide). Mean CPUE of postflexion larvae of estuary-dependent species was significantly greater in trough areas. The proportion of postflexion larval fishes in trough habitat was significantly greater than that of preflexion stages, a result that was not apparent in surf habitat sampled. CPUE of postflexion larvae of estuary-dependent fishes was negatively correlated with current magnitude and positively correlated with habitat depth. Mean body length of larval fishes was significantly greater in trough than in surf habitats. These results provide evidence that the CPUE of postflexion larvae of estuary-dependent fishes is higher in trough habitat in the surf zone and this may be indicative of active habitat selection for areas of reduced current velocity/wave action. The implications of this behaviour for estuarine recruitment processes are discussed.

A fixed tilt solar collector employing reversible vee-trough reflectors and vacuum tube receivers for solar heating and cooling systems

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1977-01-01

The usefulness of vee-trough concentrators in improving the efficiency and reducing the cost of collectors assembled from evacuated tube receivers was studied in the vee-trough/vacuum tube collector (VTVTC) project. The VTVTC was analyzed rigorously and various mathematical models were developed to calculate the optical performance of the vee-trough concentrator and the thermal performance of the evacuated tube receiver. A test bed was constructed to verify the mathematical analyses and compare reflectors made out of glass, Alzak and aluminized FEP Teflon. Tests were run at temperatures ranging from 95 to 180 C. Vee-trough collector efficiencies of 35 to 40% were observed at an operating temperature of about 175 C. Test results compared well with the calculated values. Predicted daily useful heat collection and efficiency values are presented for a year's duration of operation temperatures ranging from 65 to 230 C. Estimated collector costs and resulting thermal energy costs are presented. Analytical and experimental results are discussed along with a complete economic evaluation.

Using software security analysis to verify the secure socket layer (SSL) protocol

NASA Technical Reports Server (NTRS)

Powell, John D.

2004-01-01

nal Aeronautics and Space Administration (NASA) have tens of thousands of networked computer systems and applications. Software Security vulnerabilities present risks such as lost or corrupted data, information the3, and unavailability of critical systems. These risks represent potentially enormous costs to NASA. The NASA Code Q research initiative 'Reducing Software Security Risk (RSSR) Trough an Integrated Approach '' offers, among its capabilities, formal verification of software security properties, through the use of model based verification (MBV) to address software security risks. [1,2,3,4,5,6] MBV is a formal approach to software assurance that combines analysis of software, via abstract models, with technology, such as model checkers, that provide automation of the mechanical portions of the analysis process. This paper will discuss: The need for formal analysis to assure software systems with respect to software and why testing alone cannot provide it. The means by which MBV with a Flexible Modeling Framework (FMF) accomplishes the necessary analysis task. An example of FMF style MBV in the verification of properties over the Secure Socket Layer (SSL) communication protocol as a demonstration.

The origin of polygonal troughs on the northern plains of Mars

NASA Astrophysics Data System (ADS)

Pechmann, J. C.

1980-05-01

The morphology, distribution, geologic environment and relative age of large-scale polygonal trough systems on Mars are examined. The troughs are steep-walled, flat-floored, sinuous depressions typically 200-800 m wide, 20-120 m deep and spaced 5-10 km apart. The mechanics of formation of tension cracks is reviewed to identify the factors controlling the scale of tension crack systems; special emphasis is placed on thermal cracking in permafrost. It is shown that because of the extremely large scale of the Martian fracture systems, they could not have formed by thermal cracking in permafrost, dessication cracking in sediments or contraction cracking in cooling lava. On the basis of photogeologic evidence and analog studies, it is proposed that polygonal troughs on the northern plains of Mars are grabens.

GAS SEAL

DOEpatents

Monson, H.; Hutter, E.

1961-07-11

A seal is described for a cover closing an opening in the top of a pressure vessel that may house a nuclear reactor. The seal comprises a U-shaped trough formed on the pressure vessel around the opening therein, a mass of metal in the trough, and an edge flange on the cover extending loosely into the trough and dipping into the metal mass. The lower portion of the metal mass is kept melted, and the upper portion, solid. The solid pontion of the metal mass prevents pressure surges in the vessel from expelling the liquid portion of the metal mass from the trough; the liquld portion, thus held in place by the solid portion, does not allow gas to go through, and so gas cannot escape through shrinkage holes in the solid portion.

A vacuum tube vee-trough collector for solar heating and air conditioning applications

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1978-01-01

An analysis is conducted of the performance of a vee-trough vacuum tube collector proposed for use in solar heating and cooling applications. The vee-trough reflector is a triangular sectioned, flat surfaced reflector, whose axis is laid in the East-West direction. A vacuum tube receiver placed at the bottom of the vee-trough collects solar heat most efficiently since convection is completely eliminated. Radiation losses are reduced by use of selective coatings on the absorber. Owing to its high temperature capabilities (300-400 F), the proposed scheme could also be used for power generation applications in combination with an organic Rankine conversion system. It is especially recommended for unattended pumping stations since the reflectors only require reversal once every six months.

Method and apparatus for automatically detecting patterns in digital point-ordered signals

DOEpatents

Brudnoy, David M.

1998-01-01

The present invention is a method and system for detecting a physical feature of a test piece by detecting a pattern in a signal representing data from inspection of the test piece. The pattern is detected by automated additive decomposition of a digital point-ordered signal which represents the data. The present invention can properly handle a non-periodic signal. A physical parameter of the test piece is measured. A digital point-ordered signal representative of the measured physical parameter is generated. The digital point-ordered signal is decomposed into a baseline signal, a background noise signal, and a peaks/troughs signal. The peaks/troughs from the peaks/troughs signal are located and peaks/troughs information indicating the physical feature of the test piece is output.

Method and apparatus for automatically detecting patterns in digital point-ordered signals

DOEpatents

Brudnoy, D.M.

1998-10-20

The present invention is a method and system for detecting a physical feature of a test piece by detecting a pattern in a signal representing data from inspection of the test piece. The pattern is detected by automated additive decomposition of a digital point-ordered signal which represents the data. The present invention can properly handle a non-periodic signal. A physical parameter of the test piece is measured. A digital point-ordered signal representative of the measured physical parameter is generated. The digital point-ordered signal is decomposed into a baseline signal, a background noise signal, and a peaks/troughs signal. The peaks/troughs from the peaks/troughs signal are located and peaks/troughs information indicating the physical feature of the test piece is output. 14 figs.

Southern Sand Dunes

NASA Image and Video Library

2003-01-15

At first glance, this NASA Mars Odyssey image showing impact craters and linear ridges and troughs is typical of the southern highlands. However, upon closer examination migrating sand dunes are observed within the troughs.

Volcanism and massive sulfide formation at a sedimented spreading center, Escanaba Trough, Gorda Ridge, northeast Pacific.

USGS Publications Warehouse

Morton, J.L.; Holmes, M.L.; Koski, R.A.

1987-01-01

Seismic-reflection profiles over the sediment-filled Escanaba Trough at the southern Gorda Ridge reveal a series of volcanic centers that pierce the sediment. The volcanic edifices are 3 to 6 km in diameter and are spaced at 15 to 20 km intervals along the axis of the trough. Composition and form of sulfide samples obtained from the bank suggest significant interaction between hydrothermal fluids and sediment at depth, and deposition of sulfide within the sediment pile.-from Authors

Big Crater as Viewed by Pathfinder Lander - Anaglyph

NASA Technical Reports Server (NTRS)

1997-01-01

The 'Big Crater' is actually a relatively small Martian crater to the southeast of the Mars Pathfinder landing site. It is 1500 meters (4900 feet) in diameter, or about the same size as Meteor Crater in Arizona. Superimposed on the rim of Big Crater (the central part of the rim as seen here) is a smaller crater nicknamed 'Rimshot Crater.' The distance to this smaller crater, and the nearest portion of the rim of Big Crater, is 2200 meters (7200 feet). To the right of Big Crater, south from the spacecraft, almost lost in the atmospheric dust 'haze,' is the large streamlined mountain nicknamed 'Far Knob.' This mountain is over 450 meters (1480 feet) tall, and is over 30 kilometers (19 miles) from the spacecraft. Another, smaller and closer knob, nicknamed 'Southeast Knob' can be seen as a triangular peak to the left of the flanks of the Big Crater rim. This knob is 21 kilometers (13 miles) southeast from the spacecraft.

The larger features visible in this scene - Big Crater, Far Knob, and Southeast Knob - were discovered on the first panoramas taken by the IMP camera on the 4th of July, 1997, and subsequently identified in Viking Orbiter images taken over 20 years ago. The scene includes rocky ridges and swales or 'hummocks' of flood debris that range from a few tens of meters away from the lander to the distance of South Twin Peak. The largest rock in the nearfield, just left of center in the foreground, nicknamed 'Otter', is about 1.5 meters (4.9 feet) long and 10 meters (33 feet) from the spacecraft.

This view of Big Crater was produced by combining 6 individual 'Superpan' scenes from the left and right eyes of the IMP camera. Each frame consists of 8 individual frames (left eye) and 7 frames (right eye) taken with different color filters that were enlarged by 500% and then co-added using Adobe Photoshop to produce, in effect, a super-resolution panchromatic frame that is sharper than an individual frame would be.

The anaglyph view of Big Crater was produced by combining the left and right eye mosaics (above) by assigning the left eye view to the red color plane and the right eye view to the green and blue color planes (cyan), to produce a stereo anaglyph mosaic. This mosaic can be viewed in 3-D on your computer monitor or in color print form by wearing red-blue 3-D glasses.

Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

Click below to see the left and right views individually. [figure removed for brevity, see original site] Left [figure removed for brevity, see original site] Right

Children and wives of deceased veterans--pride and suffering.

PubMed

Gruden, V; Gruden, Z; Gruden, V

1999-06-01

A widow is a women who lost her partner, Separation is what happened to her. Every separation is a big trauma and a possible source of psychopathology. The widow's children have experienced trauma as well, with all known consequences of separation. Admixture of pride partially reduces the intensity of frustration. However, this pride will soon lead to the sense of guilt and auto-aggressive component becomes dominant. Eighty nine widows, members of the Club "April 3, 1992" in Valpovo, were examined by the means of a questionnaire. Due to the widow's anxiety, depression and thinking about their own death and children's psychosomatic disturbances there is the imperative of the long-term psychotherapeutic work with them which is aimed at the correction of possible psychopathology.

Stable interior, showing center aisle, stalls, and feed troughs. View ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Stable interior, showing center aisle, stalls, and feed troughs. View looking southwest - Fort Hill Farm, Stable, West of Staunton (Roanoke) River between Turkey & Caesar's Runs, Clover, Halifax County, VA

Concentrating Solar Power Projects | Concentrating Solar Power | NREL

Science.gov Websites

construction, or under development. CSP technologies include parabolic trough, linear Fresnel reflector, power Technology-listing by parabolic trough, linear Fresnel reflector, power tower, or dish/engine systems Status

Supersonic burning in separated flow regions

NASA Technical Reports Server (NTRS)

Zumwalt, G. W.

1982-01-01

The trough vortex phenomena is used for combustion of hydrogen in a supersonic air stream. This was done in small sizes suitable for igniters in supersonic combustion ramjets so long as the boundary layer displacement thickness is less than 25% of the trough step height. A simple electric spark, properly positioned, ignites the hydrogen in the trough corner. The resulting flame is self sustaining and reignitable. Hydrogen can be injected at the base wall or immediately upstream of the trough. The hydrogen is introduced at low velocity to permit it to be drawn into the corner vortex system and thus experience a long residence time in the combustion region. The igniters can be placed on a skewed back step for angles at least up to 30 deg. without affecting the igniter performance significantly. Certain metals (platinum, copper) act catalytically to improve ignition.

Decadal Modulation of Repeating Slow Slip Event Activity in the Southwestern Ryukyu Arc Possibly Driven by Rifting Episodes at the Okinawa Trough

NASA Astrophysics Data System (ADS)

Tu, Yoko; Heki, Kosuke

2017-09-01

We studied 38 slow slip events (SSEs) in 1997-2016 beneath the Iriomote Island, southwestern Ryukyu Arc, Japan, using continuous Global Navigation Satellite Systems data. These SSEs occur biannually on the same fault patch at a depth of 30 km on the subducting Philippine Sea Plate slab with average moment magnitudes (Mw) of 6.6. Here we show that the slip accumulation rate (cumulative slip/lapse time) of these SSEs fluctuated over a decadal time scale. The rate increased twice around 2002 and 2013 concurrently with earthquake swarms in the Okinawa Trough. This suggests that episodic activations of the back-arc spreading at the Okinawa Trough caused extra southward movement of the block south of the trough and accelerated convergence at the Ryukyu Trench.

Surface expression of the Chicxulub crater

PubMed

Pope, K O; Ocampo, A C; Kinsland, G L; Smith, R

1996-06-01

Analyses of geomorphic, soil, and topographic data from the northern Yucatan Peninsula, Mexico, confirm that the buried Chicxulub impact crater has a distinct surface expression and that carbonate sedimentation throughout the Cenozoic has been influenced by the crater. Late Tertiary sedimentation was mostly restricted to the region within the buried crater, and a semicircular moat existed until at least Pliocene time. The topographic expression of the crater is a series of features concentric with the crater. The most prominent is an approximately 83-km-radius trough or moat containing sinkholes (the Cenote ring). Early Tertiary surfaces rise abruptly outside the moat and form a stepped topography with an outer trough and ridge crest at radii of approximately 103 and approximately 129 km, respectively. Two discontinuous troughs lie within the moat at radii of approximately 41 and approximately 62 km. The low ridge between the inner troughs corresponds to the buried peak ring. The moat corresponds to the outer edge of the crater floor demarcated by a major ring fault. The outer trough and the approximately 62-km-radius inner trough also mark buried ring faults. The ridge crest corresponds to the topographic rim of the crater as modified by postimpact processes. These interpretations support previous findings that the principal impact basin has a diameter of approximately 180 km, but concentric, low-relief slumping extends well beyond this diameter and the eroded crater rim may extend to a diameter of approximately 260 km.

Comparative analyses of the bacterial community of hydrothermal deposits and seafloor sediments across Okinawa Trough

NASA Astrophysics Data System (ADS)

Wang, Long; Yu, Min; Liu, Yan; Liu, Jiwen; Wu, Yonghua; Li, Li; Liu, Jihua; Wang, Min; Zhang, Xiao-Hua

2018-04-01

As an ideal place to study back-arc basins and hydrothermal eco-system, Okinawa Trough has attracted the interests of scientists for decades. However, there are still no in-depth studies targeting the bacterial community of the seafloor sediments and hydrothermal deposits in Okinawa Trough. In the present study, we reported the bacterial community of the surface deposits of a newly found hydrothermal field in the southern Okinawa Trough, and the horizontal and vertical variation of bacterial communities in the sediments of the northern Okinawa Trough. The hydrothermal deposits had a relatively high 16S rRNA gene abundance but low bacterial richness and diversity. Epsilonproteobacteria and Bacteroidetes were predominant in hydrothermal deposits whereas Deltaproteobacteria, Gammaproteobacteria and Chloroflexi were abundant across all samples. The bacterial distribution in the seafloor of Okinawa Trough was significantly correlated to the content of total nitrogen, and had consistent relationship with total carbon. Gradual changes of sulfur-oxidizing bacteria were found with the distance away from hydrothermal fields, while the hydrothermal activity did not influence the distribution of the major clades of sulfate-reducing bacteria. Higher abundance of the sulfur cycle related genes (aprA and dsrB), and lower abundance of the bacterial ammonia-oxidizing related gene (amoA) were quantified in hydrothermal deposits. In addition, the present study also compared the inter-field variation of Epsilonproteobacteria among multi-types of hydrothermal vents, revealing that the proportion and diversity of this clade were quite various.

New details about the LGM extent and subsequent retreat of the West Antarctic Ice Sheet from the easternmost Amundsen Sea Embayment shelf

NASA Astrophysics Data System (ADS)

Klages, J. P.; Hillenbrand, C. D.; Kuhn, G.; Smith, J. A.; Graham, A. G. C.; Nitsche, F. O.; Frederichs, T.; Arndt, J. E.; Gebhardt, C.; Robin, Z.; Uenzelmann-Neben, G.; Gohl, K.; Jernas, P.; Wacker, L.

2017-12-01

In recent years several previously undiscovered grounding-zone wedges (GZWs) have been described within the Abbot-Cosgrove palaeo-ice stream trough on the easternmost Amundsen Sea Embayment shelf. These GZWs document both the Last Glacial Maximum (LGM; 26.5-19 cal. ka BP) grounding-line extent and the subsequent episodic retreat within this trough that neighbors the larger Pine Island-Thwaites trough to the west. Here we combine bathymetric, seismic, and geologic data showing that 1) the grounding line in Abbot Trough did not reach the continental shelf break at any time during the last glacial period, and 2) a prominent stacked GZW constructed from six individual wedges lying upon another was deposited 100 km upstream from the LGM grounding-line position. The available data allow for calculating volumes for most of these individual GZWs and for the entire stack. Sediment cores were recovered seawards from the outermost GZW in the trough, and from the individual wedges of the stacked GZW in order to define the LGM grounding-line extent, and provide minimum grounding-line retreat ages for the respective positions on the stacked GZW. We present implications of a grounded-ice free outer shelf throughout the last glacial period. Furthermore, we assess the significance of the grounding-line stillstand period recorded by the stacked GZW in Abbot Trough for the timing of post-LGM retreat of the West Antarctic Ice Sheet from the Amundsen Sea Embayment shelf.

Landslides in Valles Marineris, Mars

NASA Technical Reports Server (NTRS)

Lucchitta, B. K.

1979-01-01

The morphology of the landslides in the Martian equatorial troughs, the geologic structure of the troughs, the time of emplacement, the similarity to terrestrial landslides, and the origin and mechanism of transport are analyzed. About 35 large landslides well-resolved on Viking images were examined, and it is found that the major landslides cover 31,000 sq km of the trough floors, and individual slides range in area from 40 to 7000 sq km. The morphologic variations of the landslides can be attributed mainly to their degree of confinement on trough floors. Many prominent landslides appear to be of similar age and were emplaced after a major faulting that dropped the trough floors. Most sliding occurred after the created scarps were dissected into spurs, gullies, and tributary canyons. Emplacement of the landslides approximately coincided with a late episode of major eruptive activity of the Tharsis volcanoes, and it is suggested that the slides may have originated as gigantic mudflows with slump blocks at their heads. The large size of many landslides is due to the fault scarps as high as 7 km on which they formed in the absence of vigorous fluvial erosion. The landslides suggest that Mars is earthlike in some respects, which may be important for further evaluations.

Morphology-dependent water budgets and nutrient fluxes in arctic thaw ponds

USGS Publications Warehouse

Koch, Joshua C.; Gurney, Kirsty; Wipfli, Mark S.

2014-01-01

Thaw ponds on the Arctic Coastal Plain of Alaska are productive ecosystems, providing habitat and food resources for many fish and bird species. Permafrost in this region creates unique pond morphologies: deep troughs, shallow low-centred polygons (LCPs) and larger coalescent ponds. By monitoring seasonal trends in pond volume and chemistry, we evaluated whether pond morphology and size affect water temperature and desiccation, and nitrogen (N) and phosphorus (P) fluxes. Evaporation was the largest early-summer water flux in all pond types. LCPs dried quickly and displayed high early-summer nutrient concentrations and losses. Troughs consistently received solute-rich subsurface inflows, which accounted for 12 to 42 per cent of their volume and may explain higher P in the troughs. N to P ratios increased and ammonium concentrations decreased with pond volume, suggesting that P and inorganic N availability may limit ecosystem productivity in older, larger ponds. Arctic summer temperatures will likely increase in the future, which may accelerate mid-summer desiccation. Given their morphology, troughs may remain wet, become warmer and derive greater nutrient loads from their thawing banks. Overall, seasonal- to decadal-scale warming may increase ecosystem productivity in troughs relative to other Arctic Coastal Plain ponds. 

A simple model of the effects of the mid-latitude total ion trough in the bottomside F layer on HF radiowave propagation

NASA Astrophysics Data System (ADS)

Lockwood, M.

1981-06-01

Observations of the amplitudes and Doppler shifts of received HF radio waves are compared with model predictions made using a two-dimensional ray-tracing program. The signals are propagated over a sub-auroral path, which is shown to lie along the latitudes of the mid-latitude trough at times of low geomagnetic activity. Generalizing the predictions to include a simple model of the trough in the density and height of the F2 peak enables the explanation of the anomalous observed diurnal variations. The behavior of received amplitude, Doppler shift, and signal-to-noise ratio as a function of the K sub p index value, the time of day, and the season (in 17 months of continuous recording) is found to agree closely with that predicted using the statistical position of the trough as deduced from 8 years of Alouette satellite soundings. The variation in the times of the observation of large signal amplitudes with the K sub p value and the complete absence of such amplitudes when it exceeds 2.75 are two features that implicate the trough in these effects.

Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections Caused by Coagulase-Negative Staphylococci.

PubMed

Gibson, Ashley; Kaplan, Sheldon L; Vallejo, Jesus G

2018-04-26

Coagulase-negative staphylococci (CoNS) are a common cause of pediatric ventricular shunt infections. The Infectious Diseases Society of America recommends vancomycin serum troughs of 15-20 µg/mL when treating CoNS shunt infections in adult patients. We report a series of pediatric cases of CoNS shunt infections in which clinical cure was obtained with troughs < 15 µg/mL. These findings question the relevance of this recommendation in pediatric patients. © 2018 S. Karger AG, Basel.

GPS/acoustic Seafloor Geodetic Observations Near the Nankai Trough Axis

NASA Astrophysics Data System (ADS)

Tadokoro, K.; Yasuda, K.; Fujii, C.; Watanabe, T.; Nagai, S.

2013-12-01

The GPS/acoustic seafloor geodetic observation system, which uses precise acoustic ranging and kinematic GPS positioning techniques, has been developed as a useful tool for observing seafloor crustal deformations associated with plate convergence and with earthquakes that occurred in ocean area including the 2011 Tohoku-oki Earthquake of Mw 9.0. Our research group installed eight seafloor benchmarks for this observation system in source areas of anticipated major interplate earthquakes along the Nankai Trough, off southwestern Japan. We have performed campaign measurement for 4-8 years until the end of 2012. The error of displacement rate is almost 5 mm/y through the monitoring for more than four years. At the northern-most potion of the Nankai (Suruga) Trough, the observed steady horizontal displacement rate is 45 mm/y toward west. Also no significant velocity difference is observed across the trough, indicating strong interplate locking up to the shallowest segments. On the other hand, site velocities are 40 mm/y in the direction of N75W at the central region of the Nankai trough, 70-90 km landward from the trough axis. Although this result is the strong evidence for interplate locking, with coupling ratios of 60-80% on the basis of the back-slip model, it has no resolution for the interplate locking at the most-shallowest segments whose depths are 0-10 km. In other words, seaward up-dip limit of locked zone is never resolved from the present seafloor benchmark network [Tadokoro et al., 2012] . Large co-seismic slips larger than 40-50 m on the shallowest interplate segment [Ito et al., 2011; Fujii et al., 2011; Iinuma et al., 2012] are the cause of the unexpected high tsunami that has attacked the pacific coasts of the Tohoku region during the Tohoku-oki Earthquake; it is, therefore, essential to understand slip deficit or strain accumulation condition near the trench axis, also for the anticipated mega-thrust earthquake at the Nankai Trough. For this reason, we installed a new seafloor benchmark in the vicinity of the Nankai Trough axis, about 15 km landward from the trough axis, on July 16, 2013. In addition, we plan to install another new benchmark on the other side of the Nankai Trough in August of this year, to directly measure the motion of the subducting Philippine Sea Plate. The coupling ratio is calculated from slip deficit divided by convergence rate. We can directly 'measure' the coupling ratio from crustal deformation at the newly-installed station on the Philippine Sea Plate, without using global plate motion models. Acknowledgments: We are grateful to the captain and crews of R/V "Asama" of Mie Prefecture Fisheries Research Institute, Japan. This study has been partly promoted by Ministry of Education, Culture, Sports, Science and Technology, Japanese Government.

Compilation of geologic, hydrologic, and ground-water flow modeling information for the Spokane Valley-Rathdrum Prairie aquifer, Spokane County, Washington, and Bonner and Kootenai Counties, Idaho

USGS Publications Warehouse

Kahle, Sue C.; Caldwell, Rodney R.; Bartolino, James R.

2005-01-01

The U.S. Geological Survey, in cooperation with the Idaho Department of Water Resources and Washington Department of Ecology compiled and described geologic, hydrologic, and ground-water flow modeling information about the Spokane Valley-Rathdrum Prairie (SVRP) aquifer in northern Idaho and northeastern Washington. Descriptions of the hydrogeologic framework, water-budget components, ground- and surface-water interactions, computer flow models, and further data needs are provided. The SVRP aquifer, which covers about 370 square miles including the Rathdrum Prairie, Idaho and the Spokane valley and Hillyard Trough, Washington, was designated a Sole Source Aquifer by the U.S. Environmental Protection Agency in 1978. Continued growth, water management issues, and potential effects on water availability and water quality in the aquifer and in the Spokane and Little Spokane Rivers have illustrated the need to better understand and manage the region's water resources. The SVRP aquifer is composed of sand, gravel, cobbles, and boulders primarily deposited by a series of catastrophic glacial outburst floods from ancient Glacial Lake Missoula. The material deposited in this high-energy environment is coarser-grained than is typical for most basin-fill deposits, resulting in an unusually productive aquifer with well yields as high as 40,000 gallons per minute. In most places, the aquifer is bounded laterally by bedrock composed of granite, metasedimentary rocks, or basalt. The lower boundary of the aquifer is largely unknown except along the margins or in shallower parts of the aquifer where wells have penetrated its entire thickness and reached bedrock or silt and clay deposits. Based on surface geophysics, the thickness of the aquifer is about 500 ft near the Washington-Idaho state line, but more than 600 feet within the Rathdrum Prairie and more than 700 feet in the Hillyard trough based on drilling records. Depth to water in the aquifer is greatest in the northern Rathdrum Prairie (about 500 feet) and least near the city of Spokane along the Spokane River (less than about 50 feet). Ground-water flow is south from near the southern end of Lake Pend Oreille and Hoodoo Valley, through the Rathdrum Prairie, then west toward Spokane. In Spokane, the aquifer splits and water moves north through the Hillyard Trough as well as west through the Trinity Trough. From the Trinity Trough water flows north along the western arm of the aquifer. The aquifer's discharge area is along the Little Spokane River and near Long Lake, Washington. A compilation of estimates of water-budget components, including recharge (precipitation, irrigation, canal leakage, septic tank effluent, inflow from tributary basins, and flow from the Spokane River) and discharge (withdrawals from wells, flow to the Spokane and Little Spokane Rivers, evapotranspiration, and underflow to Long Lake) illustrates that these estimated values should be compared with caution due to several variables including the area and time period of interest as well as methods employed in making the estimates. Numerous studies have documented the dynamic ground-water and surface-water interaction between the SVRP aquifer and the Spokane and Little Spokane Rivers. Gains and losses vary throughout the year, as well as the locations of gains and losses. September 2004 streamflow measurements indicated that the upper reach of the Spokane River between Post Falls and downstream at Flora Road lost 321 cubic feet per second. A gain of 736 cubic feet per second was measured between the Flora Road site and downstream at Green Street Bridge. A loss of 124 cubic feet per second was measured for the reach between the Green Street Bridge and the Spokane River at Spokane gaging station. The river gained about 87 cubic feet per second between the Spokane River at Spokane gaging station and the TJ Meenach Bridge. Overall, the Spokane River gained about 284 cubic feet per second between the Post Falls,

3D Porosity Estimation of the Nankai Trough Sediments from Core-log-seismic Integration

NASA Astrophysics Data System (ADS)

Park, J. O.

2015-12-01

The Nankai Trough off southwest Japan is one of the best subduction-zone to study megathrust earthquake fault. Historic, great megathrust earthquakes with a recurrence interval of 100-200 yr have generated strong motion and large tsunamis along the Nankai Trough subduction zone. At the Nankai Trough margin, the Philippine Sea Plate (PSP) is being subducted beneath the Eurasian Plate to the northwest at a convergence rate ~4 cm/yr. The Shikoku Basin, the northern part of the PSP, is estimated to have opened between 25 and 15 Ma by backarc spreading of the Izu-Bonin arc. The >100-km-wide Nankai accretionary wedge, which has developed landward of the trench since the Miocene, mainly consists of offscraped and underplated materials from the trough-fill turbidites and the Shikoku Basin hemipelagic sediments. Particularly, physical properties of the incoming hemipelagic sediments may be critical for seismogenic behavior of the megathrust fault. We have carried out core-log-seismic integration (CLSI) to estimate 3D acoustic impedance and porosity for the incoming sediments in the Nankai Trough. For the CLSI, we used 3D seismic reflection data, P-wave velocity and density data obtained during IODP (Integrated Ocean Drilling Program) Expeditions 322 and 333. We computed acoustic impedance depth profiles for the IODP drilling sites from P-wave velocity and density data. We constructed seismic convolution models with the acoustic impedance profiles and a source wavelet which is extracted from the seismic data, adjusting the seismic models to observed seismic traces with inversion method. As a result, we obtained 3D acoustic impedance volume and then converted it to 3D porosity volume. In general, the 3D porosities show decrease with depth. We found a porosity anomaly zone with alteration of high and low porosities seaward of the trough axis. In this talk, we will show detailed 3D porosity of the incoming sediments, and present implications of the porosity anomaly zone for the megathrust fault behavior.

Regional circulation around Heard and McDonald Islands and through the Fawn Trough, central Kerguelen Plateau

NASA Astrophysics Data System (ADS)

van Wijk, Esmee M.; Rintoul, Stephen R.; Ronai, Belinda M.; Williams, Guy D.

2010-05-01

The fine-scale circulation around the Heard and McDonald Islands and through the Fawn Trough, Kerguelen Plateau, is described using data from three high-resolution CTD sections, Argo floats and satellite maps of chlorophyll a, sea surface temperature (SST) and absolute sea surface height (SSH). We confirm that the Polar Front (PF) is split into two branches over the Kerguelen Plateau, with the NPF crossing the north-eastern limits of our survey carrying 25 Sv to the southeast. The SPF was associated with a strong eastward-flowing jet carrying 12 Sv of baroclinic transport through the deepest part of Fawn Trough (relative to the bottom). As the section was terminated midway through the trough this estimate is very likely to be a lower bound for the total transport. We demonstrate that the SPF contributes to the Fawn Trough Current identified by previous studies. After exiting the Fawn Trough, the SPF crossed Chun Spur and continued as a strong north-westward flowing jet along the eastern flank of the Kerguelen Plateau before turning offshore between 50°S and 51.5°S. Measured bottom water temperatures suggest a deep water connection between the northern and southern parts of the eastern Kerguelen Plateau indicating that the deep western boundary current continues at least as far north as 50.5°S. Analysis of satellite altimetry derived SSH streamlines demonstrates a southward shift of both the northern and southern branches of the Polar Front from 1994 to 2004. In the direct vicinity of the Heard and McDonald islands, cool waters of southern origin flow along the Heard Island slope and through the Eastern Trough bringing cold Winter Water (WW) onto the plateau. Complex topography funnels flow through canyons, deepens the mixed layer and increases productivity, resulting in this area being the preferred foraging region for a number of satellite-tracked land-based predators.

Healthcare-associated Staphylococcus aureus Bacteremia in Children: Evidence for Reverse Vancomycin Creep and Impact of Vancomycin Trough Values on Outcome.

PubMed

McNeil, J Chase; Kok, Eric Y; Forbes, Andrea R; Lamberth, Linda; Hulten, Kristina G; Vallejo, Jesus G; Mason, Edward O; Kaplan, Sheldon L

2016-03-01

Elevated vancomycin minimum inhibitory concentrations (MICs) in Staphylococcus aureus have been associated with worse clinical outcomes in adults. For invasive meticillin-resistant S. aureus (MRSA) infections in adults, the Infectious Diseases Society of America recommends targeting vancomycin serum trough concentrations between 15 and 20 μg/mL. We evaluated trends in vancomycin MICs from healthcare-associated (HCA) S. aureus bacteremia isolates in children in addition to correlating vancomycin serum trough levels with clinical outcomes. Patients and isolates were identified from a prospective S. aureus surveillance study at Texas Children's Hospital (TCH). HCA S. aureus bacteremia isolates from 2003 to 2013 were selected. Vancomycin MICs by E-test were determined and medical records were reviewed. Acute kidney injury (AKI) was defined as doubling of the baseline serum creatinine. Three hundred forty-one isolates met inclusion criteria. We observed a reverse vancomycin creep among MRSA isolates in the study period with a decline in the proportion of isolates with vancomycin MIC ≥ 2 μg/mL (from 32.7% to 5.6%; P < 0.001). However, the proportion of MSSA isolates with MIC ≥ 2 μg/mL increased (from 2.9% to 9%; P = 0.04). Among patients who had vancomycin troughs performed, there was no difference in duration of bacteremia or fever with vancomycin trough >15 versus <15 μg/mL. A vancomycin trough >15 μg/mL was, however, an independent risk factor for AKI. Vancomycin MICs are shifting among HCA S. aureus bacteremia isolates with significant differences between MRSA and MSSA at TCH. Higher vancomycin troughs did not improve outcomes in pediatric HCA S. aureus bacteremia but were associated with increased nephrotoxicity. Further studies are needed to better understand optimal management of children with S. aureus bacteremia.

Molten salt parabolic trough system with synthetic oil preheating

NASA Astrophysics Data System (ADS)

Yuasa, Minoru; Hino, Koichi

2017-06-01

Molten salt parabolic trough system (MSPT), which can heat the heat transfer fluid (HTF) to 550 °C has a better performance than a synthetic oil parabolic trough system (SOPT), which can heat the HTF to 400 °C or less. The utilization of HTF at higher temperature in the parabolic trough system is able to realize the design of a smaller size of storage tank and higher heat to electricity conversion efficiency. However, with MSPT there is a great amount of heat loss at night so it is necessary to circulate the HTF at a high temperature of about 290 °C in order to prevent solidification. A new MSPT concept with SOPT preheating (MSSOPT) has been developed to reduce the heat loss at night. In this paper, the MSSOPT system, its performance by steady state analysis and annual performance analysis are introduced.

Balancing vancomycin efficacy and nephrotoxicity: should we be aiming for trough or AUC/MIC?

PubMed

Patel, Karisma; Crumby, Ashley S; Maples, Holly D

2015-04-01

Sixty years later, the question that still remains is how to appropriately utilize vancomycin in the pediatric population. The Infectious Diseases Society of America published guidelines in 2011 that provide guidance for dosing and monitoring of vancomycin in adults and pediatrics. However, goal vancomycin trough concentrations of 15-20 μg/mL for invasive infections caused by methicillin-resistant Staphylococcus aureus were based primarily on adult pharmacokinetic and pharmacodynamic data that achieved an area under the curve to minimum inhibitory concentration ratio (AUC/MIC) of ≥400. Recent pediatric literature shows that vancomycin trough concentrations needed to achieve the target AUC/MIC are different than the adult goal troughs cited in the guidelines. This paper addresses several thoughts, including the role of vancomycin AUC/MIC in dosing strategies and safety monitoring, consistency in laboratory reporting, and future directions for calculating AUC/MIC in pediatrics.

Paleoenvironmental Assessment and Deglacial Chronology of the Onondaga Trough, Onondaga County, New York

USGS Publications Warehouse

Kappel, William M.; Teece, Mark A.

2007-01-01

Introduction The U.S. Geological Survey, in cooperation with the Onondaga Lake Partnership and Onondaga Environmental Institute, has been studying the hydrogeology of the Onondaga Trough since 2002 to determine the movement and concentration of naturally occurring brine in the glacial valley-fill aquifer. Numerous shallow and deep test holes have been drilled to determine the glacial and water-quality stratigraphy in the Onondaga Trough. Organic materials were recovered from the Onondaga Creek, Ninemile Creek, and Harbor Brook valleys, and from lakebed sediments in Onondaga Lake (fig. 1) and age-dated with carbon-isotope analysis techniques. This report summarizes the carbon-isotope data collected from 1996 through 2006 in the Onondaga Trough. The results of these analyses provide a means to understand the deglaciation of the watershed and the development of the watershed from barren glacial sediment to a forested ecosystem.

Formations in Context (or, what is it?)

NASA Image and Video Library

2018-04-02

This image from NASA's Mars Reconnaissance Orbiter is a close-up of a trough, along with channels draining into the depression. Some HiRISE images show strange-looking formations. Sometimes it helps to look at Context Camera images to understand the circumstances of a scene -- like this cutout from CTX 033783_1509 -- which here shows an impact crater with a central peak, and a collapse depression with concentric troughs just north of that peak. On the floor of the trough is some grooved material that we typically see in middle latitude regions where there has been glacial flow. These depressions with concentric troughs exist elsewhere on Mars, and their origins remain a matter of debate. NB: The Context Camera is another instrument onboard MRO, and it has a larger viewing angle than HiRISE, but less resolution capability than our camera. https://photojournal.jpl.nasa.gov/catalog/PIA22348

Oblique H.F. radiowave propagation in the main trough region of the ionosphere

NASA Astrophysics Data System (ADS)

Lockwood, M.; Mitchell, V. B.

1980-12-01

The propagation of 7.335 MHz, CW signals over a 5212 km subauroral, west-east path is studied. Measurements and semiempirical predictions are made of the amplitude distributions and Doppler shifts of the received signals. The observed amplitude distribution is fitted with a numerical fading model, yielding the power losses suffered by the signals during propagation via the predominating modes. The mid-latitude trough in the F2 peak ionization density is predicted by a statistical model to be at the latitudes of this path at these times and at low K sub p values; a sharp cut-off in low-power losses at a mean K sub p of 2.75 strongly implicates the trough in the propagation of these signals. It is shown that a simple extension of this model to allow for the trough can reproduce the form of the observed diurnal variation.

Interannual variation of springtime biomass burning in Indochina: Regional differences, associated atmospheric dynamical changes, and downwind impacts.

PubMed

Huang, Wan-Ru; Wang, Sheng-Hsiang; Yen, Ming-Cheng; Lin, Neng-Huei; Promchote, Parichart

2016-09-16

During March and April, widespread burning occurs across farmlands in Indochina in preparation for planting at the monsoon onset. The resultant aerosols impact the air quality downwind. In this study, we investigate the climatic aspect of the interannual variation of springtime biomass burning in Indochina and its correlation with air quality at Mt. Lulin in Taiwan using long-term (2005-2015) satellite and global reanalysis data. Based on empirical orthogonal function (EOF) analysis, we find that the biomass burning activities vary with two geographical regions: northern Indochina (the primary EOF mode) and southern Indochina (the secondary EOF mode). We determine that the variation of biomass burning over northern Indochina is significantly related with the change in aerosol concentrations at Mt. Lulin. This occurs following the change in the so-called India-Burma Trough in the lower and middle troposphere. When the India-Burma Trough is intensified, a stronger northwesterly wind (to the west of the trough) transports the dryer air from higher latitude into northern Indochina, and this promotes local biomass burning activities. The increase in upward motion to the east of the intensified India-Burma Trough lifts the aerosols, which are transported toward Taiwan by the increased low-level westerly jet. Further diagnoses revealed the connection between the India-Burma Trough and the South Asian jet's wave train pattern as well as the previous winter's El Niño - Southern Oscillation phase. This information highlights the role of the India-Burma Trough in modulating northern Indochina biomass burning and possibly predicting aerosol transport to East Asia on the interannual time scale.

Old flying ice-rock body in space allows a glance at its inner working.

NASA Astrophysics Data System (ADS)

Bieler, A. M.

2015-12-01

I am studying old, cold bodies of rock and ice flying through space, usually far, far away from the Sun. They are even behind the last of the big 8 balls we call our home worlds. (There were 9 balls a few yearsago, but then one of the balls was not considered a ball anymore by some people and he/she had to leave the group.)Because they are so far away from the Sun, they remain dark and very cold for the most part of their life.That is why even most of the very nervous stuff sticks on them ever since. With stuff I mean the little things that the Sun, the big 8 balls, we humans and everything else that is flying around the Sun ismade of. The nervous ones quickly change into something wind like andcan get lost. But the cold on the ice-rock bodies slows this down andthey stick around. This makes those ice-rock bodies interesting tostudy, they did not change too much since they were made.I study news sent back from a computer controlled box flying around oneof those rock-ice things that is now closer to the Sun. When thespace between such a body and the Sun gets smaller, it warms up andsome of the ice changes into wind like things. We find out how muchof what stuff is flying away from that body and at what time.Then I and my friends put those numbers into a big ass computer to findout more on how those rock-ice bodies work. Where does the wind comefrom? Do they all come from the same place or only some? Is it really the Sun's fault? How many cups of ice change into wind each day? Many questions.

Concentrating Solar Power Projects - DEWA CSP Trough Project |

Science.gov Websites

: Parabolic trough Turbine Capacity: Net: 600.0 MW Gross: 600.0 MW Status: Under development Start Year: 2020 Ground: 2018 Start Production: 2020 PPA/Tariff Rate: 7.3 US cents per kWh Participants Developer(s): ACWA

Landslides in Valles Marineris, Mars.

USGS Publications Warehouse

Lucchitta, B.K.

1979-01-01

Large landslides in the Martian equatorial troughs have been investigated with respect to morphology, geologic structure of the troughs, time of emplacement, similarity to terrestrial landslides, and origin and mechanism of transport. The morphologic variations of the landslides can be attributed mainly to their degree of confinement on trough floors. The huge size of many landslides is due to their occurrence on fault scarps that may have attained several kilometers in height in the absence of vigorous fluvial erosion on Mars. The mechanical efficiency of the Martian landslides is high but in accord with predictions from large landslides on earth. -from Author

Optical and mechanical tolerances in hybrid concentrated thermal-PV solar trough.

PubMed

Diaz, Liliana Ruiz; Cocilovo, Byron; Miles, Alexander; Pan, Wei; Blanche, Pierre-Alexandre; Norwood, Robert A

2018-05-14

Hybrid thermal-PV solar trough collectors combine concentrated photovoltaics and concentrated solar power technology to harvest and store solar energy. In this work, the optical and mechanical requirements for optimal efficiency are analyzed using non-sequential ray tracing techniques. The results are used to generate opto-mechanical tolerances that can be compared to those of traditional solar collectors. We also explore ideas on how to relieve tracking tolerances for single-axis solar collectors. The objective is to establish a basis for tolerances required for the fabrication and manufacturing of hybrid solar trough collectors.

Baby Spider: Growth of a Martian Trough Network

NASA Image and Video Library

2016-12-20

This image from NASA Mars Reconnaissance Orbiter shows the growth of a branching network of troughs carved by thawing carbon dioxide over the span of three Martian years. This process is believed to also form larger radially patterned channel features known as Martian "spiders." The image is one of three taken by the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter and included in a report on the first detection of such troughs persisting and growing, from one Mars year to the next. An animation is available at http://photojournal.jpl.nasa.gov/catalog/PIA21257

Optimization of woven jute/glass fibre-reinforced polyester hybrid composite solar parabolic trough collector

NASA Astrophysics Data System (ADS)

Reddy, K. S.; Singla, Hitesh

2017-07-01

In the present work, structural analysis of 5.77m × 4m woven jute (J)/glass (G) fibre-reinforced polyester hybrid composite solar parabolic trough is carried out based on trough parameters to obtain the minimum RMS local slope deviation, termed as SDx value under gravity loading. The optimization is done by varying parameters viz. direction and size of reinforced conduits, stacking number and sequence of hybrid trough laminate at fibre orientation of Δθ=45° and Δθ=60° amongst the layers at 0° collector angle. The analysis revealed that the configuration in which the conduits are placed in both X and Y directions is preferred over other configurations to scale down the effect of wind loads. Furthermore it has been observed that laminate of the order [0°G/45°G/-45°J/90°J]s undergoes minimum surface deformation amongst all the other configurations at conduit reinforcement in both X and Y directions for a conduit thickness of 0.75 mm and radius of 10 mm and obtains the overall SDx value of 1.3492 mrad. The results shows that proposed trough model is very promising and evolves a cost effective system.

Investigating the reasons of variability in Si IV and C IV broad absorption line troughs of quasars

NASA Astrophysics Data System (ADS)

Stathopoulos, Dimitrios; Lyratzi, Evangelia; Danezis, Emmanuel; Antoniou, Antonios; Tzimeas, Dimitrios

2017-09-01

In this paper we analyze the C IV and Si IV broad absorption troughs of two BALQSOs (J101056.69+355833.3, J114548.38+393746.6) to the individual components they consist of. By analyzing a BAL trough to its components we have the advantage to study the variations of the individual absorbing systems in the line of sight and not just the variations of the whole absorption trough or the variations of selected portions of BAL troughs exhibiting changes. We find that the velocity shifts and FWHMs (Full Width at Half Maximum) of the individual components do not vary between an interval of six years. All variable components show changes in the optical depths at line centers which are manifested as variations in the EW (Equivalent Width) of the components. In both BALQSOs, over corresponding velocities, Si IV has higher incidence of variability than C IV. From our analysis, evidence is in favour of different covering fractions between C IV and Si IV. Finally, although most of our results favour the crossing cloud scenario as the cause of variability, there is also strong piece of evidence indicating changing ionization as the source of variability. Thus, a mixed situation where both physical mechanisms contribute to BAL variability is the most possible scenario.

[Successful cyclosporine treatment in 2 patients with refractory CIDP, involving monitoring of both AUC(0-4h) and trough levels].

PubMed

Takeuchi, Akiko; Shirai, Shinichi; Horiuchi, Kazuhiro; Takahashi, Ikuko; Matsushima, Masaaki; Hirotani, Makoto; Kano, Takahiro; Yabe, Ichiro; Matumoto, Akihisa; Sasaki, Hidenao

2012-01-01

Cyclosporine A (CYA) treatment has been reported to be probably useful for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that is resistant to conventional treatment. Although several studies have shown that appropriate area under the concentration-time curve (AUC) monitoring of CYA levels results in improved outcomes for refractory nephrotic syndrome patients, the importance of using AUC analysis for CIDP remains unclear. In this study, we measured both trough and AUC from 0 to 4 h (AUC(0-4 h)) levels of CYA in 2 patients with CIDP and compared the findings for the clinical parameters. On the basis of the CYA dosing recommendations for patients with nephrotic syndrome, we used a CYA concentration of 150 ng/ml for the trough level and an AUC(0-4 h) value of 2,500 ng/(ml·h). Patient 1 showed a significant increase in grip strength and a prolonged remission period. Patient 2 showed improvement in the modified Rankin scale and manual muscle test (MMT) scores. Monitoring both AUC(0-4 h) and trough levels of CYA seems to be a better option than monitoring the trough level alone because it leads to improved estimation of the efficacy and safety of CYA treatment in the case of CIDP patients.

O+ trough zones in the polar cap ionosphere-magnetosphere coupling region

NASA Astrophysics Data System (ADS)

Horwitz, James; Zeng, Wen; Jaafari, Fajer

Regions of low-density troughs in O+ have been observed at 1 RE altitude in the polar cap ionosphere-magnetosphere region by the Thermal Ion Dynamics Experiment(TIDE) on the POLAR spacecraft. In this presentation, the UT Arlington Dynamic Fluid-Kinetic (DyFK) code is employed to investigate the formation of such O+ density troughs. We utilize convection paths of flux tubes in the high-latitude region as prescribed by an empirical convection model with solar wind inputs to track the evolution of ionospheric plasma transport and in particular O+ densities along these tubes with time/space. The flux tubes are subjected to auroral processes of precipitation and wave-driven ion heating when they pass through the auroral oval, which tends to elevate the plasma densities in these tubes. When the F-regions of such tubes traverse locations where the F-region is in darkness, recombination there causes the higher-altitude regions to drain and the densities to decline throughout. Owing to the varying effects of these processes, significant and low trough-like densities at higher altitudes developed along these flux tubes. The modeled densities near 6000 km altitudes will be compared with multiple POLAR passes featuring POLAR/TIDE-measured O+ densities for inside and outside of such trough regions.

Two new methods used to simulate the circumferential solar flux density concentrated on the absorber of a parabolic trough solar collector

NASA Astrophysics Data System (ADS)

Guo, Minghuan; Wang, Zhifeng; Sun, Feihu

2016-05-01

The optical efficiencies of a solar trough concentrator are important to the whole thermal performance of the solar collector, and the outer surface of the tube absorber is a key interface of energy flux. So it is necessary to simulate and analyze the concentrated solar flux density distributions on the tube absorber of a parabolic trough solar collector for various sun beam incident angles, with main optical errors considered. Since the solar trough concentrators are linear focusing, it is much of interest to investigate the solar flux density distribution on the cross-section profile of the tube absorber, rather than the flux density distribution along the focal line direction. Although a few integral approaches based on the "solar cone" concept were developed to compute the concentrated flux density for some simple trough concentrator geometries, all those integral approaches needed special integration routines, meanwhile, the optical parameters and geometrical properties of collectors also couldn't be changed conveniently. Flexible Monte Carlo ray trace (MCRT) methods are widely used to simulate the more accurate concentrated flux density distribution for compound parabolic solar trough concentrators, while generally they are quite time consuming. In this paper, we first mainly introduce a new backward ray tracing (BRT) method combined with the lumped effective solar cone, to simulate the cross-section flux density on the region of interest of the tube absorber. For BRT, bundles of rays are launched at absorber-surface points of interest, directly go through the glass cover of the absorber, strike on the uniformly sampled mirror segment centers in the close-related surface region of the parabolic reflector, and then direct to the effective solar cone around the incident sun beam direction after the virtual backward reflection. All the optical errors are convoluted into the effective solar cone. The brightness distribution of the effective solar cone is supposed to be circular Gaussian type. Then a parabolic trough solar collector of Euro Trough 150 is used as an example object to apply this BRT method. Euro Trough 150 is composed of RP3 mirror facets, with the focal length of 1.71m, aperture width of 5.77m, outer tube diameter of 0.07m. Also to verify the simulated flux density distributions, we establish a modified MCRT method. For this modified MCRT method, the random rays with weighted energy elements are launched in the close-related rectangle region in the aperture plane of the parabolic concentrator and the optical errors are statistically modeled in the stages of forward ray tracing process. Given the same concentrator geometric parameters and optical error values, the simulated results from these two ray tracing methods are in good consistence. The two highlights of this paper are the new optical simulation method, BRT, and figuring out the close-related mirror surface region for BRT and the close-related aperture region for MCRT in advance to effectively simulate the solar flux distribution on the absorber surface of a parabolic trough collector.

Multiple-Panel Cylindrical Solar Concentrator

NASA Technical Reports Server (NTRS)

Brown, E. M.

1983-01-01

Trough composed of many panels concentrates Sun's energy on solar cells, even when trough is not pointed directly at Sun. Tolerates deviation as great as 5 degrees from direction of sun. For terrestrial applications, multiple-flat-plate design offers potential cost reduction and ease of fabrication.

Assessment of undiscovered continuous oil and gas resources in the Hanoi Trough, Vietnam, 2017

USGS Publications Warehouse

Schenk, Christopher J.; Tennyson, Marilyn E.; Mercier, Tracey J.; Woodall, Cheryl A.; Le, Phuong A.; Klett, Timothy R.; Finn, Thomas M.; Leathers-Miller, Heidi M.; Gaswirth, Stephanie B.; Marra, Kristen R.

2018-02-13

Using a geology-based assessment methodology, the U.S. Geological Survey estimated mean undiscovered, technically recoverable continuous resources of 52 million barrels of oil and 591 billion cubic feet of gas in the Hanoi Trough of Vietnam.

A giant, submarine creep zone as a precursor of large-scale slope instability offshore the Dongsha Islands (South China Sea)

NASA Astrophysics Data System (ADS)

Li, Wei; Alves, Tiago M.; Wu, Shiguo; Rebesco, Michele; Zhao, Fang; Mi, Lijun; Ma, Benjun

2016-10-01

A giant submarine creep zone exceeding 800 km2 on the continental slope offshore the Dongsha Islands, South China Sea, is investigated using bathymetric and 3D seismic data tied to borehole information. The submarine creep zone is identified as a wide area of seafloor undulations with ridges and troughs. The troughs form NW- and WNW-trending elongated depressions separating distinct seafloor ridges, which are parallel or sub-parallel to the continental slope. The troughs are 0.8-4.7 km-long and 0.4 to 2.1 km-wide. The ridges have wavelengths of 1-4 km and vertical relief of 10-30 m. Slope strata are characterised by the presence of vertically stacked ridges and troughs at different stratigraphic depths, but remaining relatively stationary in their position. The interpreted ridges and troughs are associated with large-scale submarine creep, and the troughs can be divided into three types based on their different internal characters and formation processes. The large-scale listric faults trending downslope below MTD 1 and horizon T0 may be the potential glide planes for the submarine creep movement. High sedimentation rates, local fault activity and the frequent earthquakes recorded on the margin are considered as the main factors controlling the formation of this giant submarine creep zone. Our results are important to the understanding of sediment instability on continental slopes as: a) the interpreted submarine creep is young, or even active at present, and b) areas of creeping may evolve into large-scale slope instabilities, as recorded by similar large-scale events in the past.

Geologic evolution of the Kastel trough and its implications on the Adiyaman oil fields, SE Turkey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coskun, Bu.

1990-05-01

Oil field developments of the Adiyaman area one of the main oil producing zones in southeast Turkey, have been highly influenced by geologic evolution of the Kastel trough which is situated in front of the suture zone between the Arabian and Anatolian plates. The Upper Cretaceous movements created many paleostructural trends in the Kastel trough where important dolomitic and porous reservoirs exist. The most important tectonic event, which appeared during the Upper Cretaceous movements, is the accumulation of the Kocali-Karadut ophiolitic complex, advancing from the north to the south in the Kastel trough, where heavy materials caused formation of amore » structural model favoring generation and migration and entrapment of oil in the reservoir rocks. Due to the presence of the Kocali-Karadut complex in the Kastel trough the following zones have been distinguished. (1) North Uplift Area. Situated under the allochthonous units, many thrust and reverse faults characterize this zone. The presence of paleohighs, where primary dolomites develop, allows the appearance of some oil fields in the region. This is the main future exploration zone in southeast Turkey. (2) Accumulation Area. Advancing from the north to the south, the allochthonous Kocali-Karadut complex filled the Kastel trough creating a deep graben whose flanks present generally normal faults. (3) Structural Belt. Important paleohighs constitute an exploration trend in this zone where dolomitic and porous carbonates contain actual oil fields. (4) South Accumulation Area. Distant from the Arabian-Anatolian suture zone, regional tectonics and sedimentology show this zone remained deeply buried during geologic time; good source rocks were deposited during the Cretaceous. (5) South Uplift Area. This area corresponds to the northern flank of the huge regional Mardin high in southeast Turkey where new oil fields have been discovered.« less

Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice

PubMed Central

De Cock, R. F. W.; Allegaert, K.; Vanhaesebrouck, S.; Danhof, M.; Knibbe, C. A. J.

2015-01-01

Based on a previously derived population pharmacokinetic model, a novel neonatal amikacin dosing regimen was developed. The aim of the current study was to prospectively evaluate this dosing regimen. First, early (before and after second dose) therapeutic drug monitoring (TDM) observations were evaluated for achieving target trough (<3 mg/liter) and peak (>24 mg/liter) levels. Second, all observed TDM concentrations were compared with model-predicted concentrations, whereby the results of a normalized prediction distribution error (NPDE) were considered. Subsequently, Monte Carlo simulations were performed. Finally, remaining causes limiting amikacin predictability (i.e., prescription errors and disease characteristics of outliers) were explored. In 579 neonates (median birth body weight, 2,285 [range, 420 to 4,850] g; postnatal age 2 days [range, 1 to 30 days]; gestational age, 34 weeks [range, 24 to 41 weeks]), 90.5% of the observed early peak levels reached 24 mg/liter, and 60.2% of the trough levels were <3 mg/liter (93.4% ≤5 mg/liter). Observations were accurately predicted by the model without bias, which was confirmed by the NPDE. Monte Carlo simulations showed that peak concentrations of >24 mg/liter were reached at steady state in almost all patients. Trough values of <3 mg/liter at steady state were documented in 78% to 100% and 45% to 96% of simulated cases with and without ibuprofen coadministration, respectively; suboptimal trough levels were found in patients with postnatal age <14 days and current weight of >2,000 g. Prospective evaluation of a model-based neonatal amikacin dosing regimen resulted in optimized peak and trough concentrations in almost all patients. Slightly adapted dosing for patient subgroups with suboptimal trough levels was proposed. This model-based approach improves neonatal dosing individualization. PMID:26248375

Gas potential of the Rome Trough in Kentucky: Results of recent Cambrian exploration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, D.C.; Drahovzal, J.A.

1996-09-01

A recent gas discovery in the Rome Trough suggests the need to re-evaluate the deep Cambrian potential of eastern Kentucky. A new phase of Cambrian exploration began in mid-1994 with a new pool discovery by the Carson Associates No. 1 Kazee well in Elliott County, Ky. This well blew out and initially flowed 11 MMcfd of gas from the upper Conasauga Group/Rome Formation at 6,258 to 6,270 feet. After this discovery, a second exploratory well (the Blue Ridge No. 1Greene) was drilled on a separate structure in Elliott County in late 1995. The Blue Ridge well was temporarily abandoned, butmore » had shows of gas and condensate. In early 1996, Carson Associates offset their initial discovery well with the No. 33 Lawson Heirs well. This activity follows a frustrating exploration history in the Rome Trough that is marked by numerous gas and oil shows, but rare commercial production. Only three single-well pools have produced commercial gas from the trough, including the recent Kazee well. Stratigraphic units below the Cambrian-Ordovician Knox Group in the Rome Trough are dramatically thicker than their equivalents on the shelf to the north. The interval in the trough is thought to include rocks as old as Early Cambrian, consisting of a basal sandstone, equivalents of the Shady/Tomstown Dolomite, the Rome Formation, and the Conasauga Formation. Sandstones and fractured shales have been responsible for most of the production to date, but dolostone intervals may also have potential. Limited seismic data indicate possible fan-delta and basin-floor fan deposits that may have reservoir potential.« less

Movement of fluids in the Nankai Trough area: Insights from 129I and halogen distributions along the IODP NanTroSEIZE transect

NASA Astrophysics Data System (ADS)

Tomaru, Hitoshi; Fehn, Udo

2015-01-01

Halogen concentrations and 129I/I ratios were determined in pore waters from the Nankai Trough subduction system, collected during IODP Expeditions 315, 316, 322, and 333 along the NanTroSEIZE transect. The transect allowed the first direct comparison of iodine results across an active subduction system, from subducting oceanic sediments to the accretionary prism, and the overlying forearc basin. In contrast to the other halogens (Cl and Br) iodine concentrations show large variations within and among the cores at all sites landward of the trough, I concentrations increase rapidly with depth and reach values several orders of magnitude higher than those in seawater, but are only slightly higher than seawater values at the seaward sites. Methane concentrations follow a similar pattern. Host sediments of the fluids are younger than 7 Ma in all the cores, but the ages of iodine in pore waters at the landward sites reach values beyond 30 Ma. In contrast, iodine seaward of the trough is in isotopic equilibrium with the host sediments, resulting in very similar iodine and sediment ages. The distribution of iodine concentrations and ages indicates that iodine at the landward sites has been transported there in aqueous fluids, probably together with methane, from old formations in the upper plate. The specific fluid pathways potentially were influenced by features such as the megasplay fault in the prism or the décollement. The results demonstrate large-scale transport of fluids carrying iodine and other compounds such as methane from old layers in the upper plate to surface locations landward of the Nankai Trough, while separate, but only local hydrologic processes occur in the marine sediments moving toward the trough.

Structure of the lower crust beneath the Carolina Trough, U.S. Atlantic continental margin

USGS Publications Warehouse

Tréhu, Anne M.; Ballard, A.; Dorman, L.M.; Gettrust, J.F.; Klitgord, Kim D.; Schreiner, A.

1989-01-01

Data from three large-offset seismic profiles provide information on the crustal structure beneath the Carolina trough. The profiles, obtained by the U.S. Geological Survey, the Naval Oceanographic Research Development Agency, and the Scripps Institution of Oceanography in 1985, were oriented parallel to the trough and were located (1) seaward of the East Coast Magnetic Anomaly (ECMA), which is generally thought to represent the boundary between oceanic and continental crust; (2) along the axis of the trough between the ECMA and the hinge zone, which is thought to reflect the landward limit of highly stretched and altered transitional crust; and (3) along the Carolina platform landward of the basement hinge zone on crust thought to have been thinned only slightly during rifting. These data constrain the velocity structure of the lower crust and provide evidence for a thick lens of high-velocity (>7.1 km/s) lower crustal material that extends beneath the Carolina trough and the adjacent ocean basin. This lens reaches a maximum thickness of about 13 km beneath the deepest part of the trough, thins to about 5 km seaward of the ECMA, and is either very thin or absent landward of the hinge zone. It is interpreted to represent material that was underplated beneath and/or intruded into the crust during the late stage of continental rifting and that led to an anomalously thick plutonic layer during the early seafloor spreading phase. These data thus support the recent conclusions of White et al. (1987b) and Mutter et al. (1988) that the initiation of seafloor spreading is attended in many, if not most, cases by the generation of an anomalously large volume of melt.

Top predators in relation to bathymetry, ice and krill during austral winter in Marguerite Bay, Antarctica

USGS Publications Warehouse

Ribic, C.A.; Chapman, E.; Fraser, William R.; Lawson, G.L.; Wiebe, P.H.

2008-01-01

A key hypothesis guiding the US Southern Ocean Global Ocean Ecosystems Dynamics (US SO GLOBEC) program is that deep across-shelf troughs facilitate the transport of warm and nutrient-rich waters onto the continental shelf of the Western Antarctic Peninsula, resulting in enhanced winter production and prey availability to top predators. We tested aspects of this hypothesis during austral winter by assessing the distribution of the resident pack-ice top predators in relation to these deep across-shelf troughs and by investigating associations between top predators and their prey. Surveys were conducted July-August 2001 and August-September 2002 in Marguerite Bay, Antarctica, with a focus on the main across-shelf trough in the bay, Marguerite Trough. The common pack-ice seabird species were snow petrel (Pagodroma nivea, 1.2 individuals km-2), Antarctic petrel (Thalassoica antarctica, 0.3 individuals km-2), and Ade??lie penguin (Pygoscelis adeliae, 0.5 individuals km-2). The most common pack-ice pinniped was crabeater seal (Lobodon carcinophagus). During both winters, snow and Antarctic petrels were associated with low sea-ice concentrations independent of Marguerite Trough, while Ade??lie penguins occurred in association with this trough. Krill concentrations, both shallow and deep, also were associated with Ade??lie penguin and snow petrel distributions. During both winters, crabeater seal occurrence was associated with deep krill concentrations and with regions of lower chlorophyll concentration. The area of lower chlorophyll concentrations occurred in an area with complex bathymetry close to land and heavy ice concentrations. Complex or unusual bathymetry via its influence on physical and biological processes appears to be one of the keys to understanding how top predators survive during the winter in this Antarctic region. ?? 2007 Elsevier Ltd. All rights reserved.

Optical analysis of a photovoltaic V-trough system installed in western India.

PubMed

Maiti, Subarna; Sarmah, Nabin; Bapat, Pratap; Mallick, Tapas K

2012-12-20

The low concentrating photovoltaic (PV) system such as a 2× V-trough system can be a promising choice for enhancing the power output from conventional PV panels with the inclusion of thermal management. This system is more attractive when the reflectors are retrofitted to the stationary PV panels installed in a high aspect ratio in the north-south direction and are tracked 12 times a year manually according to preset angles, thus eliminating the need of diurnal expensive tracking. In the present analysis, a V-trough system facing exactly the south direction is considered, where the tilt angle of the PV panels' row is kept constant at 18.34°. The system is installed on the terrace of CSIR-Central Salt and Marine Chemicals Research Institute in Bhavnagar, Gujarat, India (21.47 N, 71.15 E). The dimension of the entire PV system is 9.64 m×0.55 m. The V-troughs made of anodized aluminum reflectors (70% specular reflectivity) had the same dimensions. An in-house developed; experimentally validated Monte Carlo ray-trace model was used to study the effect of the angular variation of the reflectors throughout a year for the present assembly. Results of the ray trace for the optimized angles showed the maximum simulated optical efficiency to be 85.9%. The spatial distribution of solar intensity over the 0.55 m dimension of the PV panel due to the V-trough reflectors was also studied for the optimized days in periods that included solstices and equinoxes. The measured solar intensity profiles with and without the V-trough system were used to calculate the actual optical efficiencies for several sunny days in the year, and results were validated with the simulated efficiencies within an average error limit of 10%.

Evaluating the Relationship between Vancomycin Trough Concentration and 24-Hour Area under the Concentration-Time Curve in Neonates.

PubMed

Tseng, Sheng-Hsuan; Lim, Chuan Poh; Chen, Qi; Tang, Cheng Cai; Kong, Sing Teang; Ho, Paul Chi-Lui

2018-04-01

Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC 24 /MIC) of >400 as the best predictor of successful treatment against MRSA infections when the MIC is ≤1 mg/liter. The relationship between steady-state vancomycin trough concentrations and AUC 24 values (mg·h/liter) has not been studied in an Asian neonatal population. We conducted a retrospective chart review in Singapore hospitals and collected patient characteristics and therapeutic drug monitoring data from neonates on vancomycin therapy over a 5-year period. A one-compartment population pharmacokinetic model was built from the collected data, internally validated, and then used to assess the relationship between steady-state trough concentrations and AUC 24 A Monte Carlo simulation sensitivity analysis was also conducted. A total of 76 neonates with 429 vancomycin concentrations were included for analysis. Median (interquartile range) was 30 weeks (28 to 36 weeks) for postmenstrual age (PMA) and 1,043 g (811 to 1,919 g) for weight at the initiation of treatment. Vancomycin clearance was predicted by weight, PMA, and serum creatinine. For MRSA isolates with a vancomycin MIC of ≤1, our major finding was that the minimum steady-state trough concentration range predictive of achieving an AUC 24 /MIC of >400 was 8 to 8.9 mg/liter. Steady-state troughs within 15 to 20 mg/liter are unlikely to be necessary to achieve an AUC 24 /MIC of >400, whereas troughs within 10 to 14.9 mg/liter may be more appropriate. Copyright © 2018 American Society for Microbiology.

Spatial patterns of cyanobacterial mat growth on sand ripples

NASA Astrophysics Data System (ADS)

Mariotti, G.; Klepac-Ceraj, V.; Perron, J. T.; Bosak, T.

2016-02-01

Photosynthetic microbial mats produce organic matter, cycle nutrients, bind pollutants and stabilize sediment in sandy marine environments. Here, we investigate the influence of bedforms and wave motion on the growth rate, composition and spatial variability of microbial mats by growing cyanobacterial mats on a rippled bed of carbonate sand in a wave tank. The tank was forced with an oscillatory flow with velocities below the threshold for sediment motion yet able to induce a porewater flow within the sediment. Different spatial patterns developed in mats depending on the initial biochemistry of the water medium. When growing in a medium rich in nitrogen, phosphorous and micronutrients, mats grew faster on ripple troughs than on ripple crests. After two months, mats covered the bed surface uniformly, and the microbial communities on the crests and in the troughs had similar compositions. Differences in bed shear stress and nutrient availability between crests and troughs were not able to explain the faster growth in the troughs. We hypothesize that this growth pattern is due to a "strainer" effect, i.e. the suspended bacteria from the inoculum were preferentially delivered to troughs by the wave-induced porewater flow. In the experiments initiated in a medium previously used up by a microbial mat and thus depleted in nutrients, mats grew preferentially on the ripple crests. This spatial pattern persisted for nearly two years, and the microbial composition on troughs and crests was different. We attribute this pattern to the upwelling of porewater in the crests, which increased the delivery of nutrients from sediment to the cyanobacteria on the bed surface. Thus, the macroscopic patterns formed by photosynthetic microbial mats on sand ripples may be used to infer whether mats are nutrient-limited and whether they are recently colonized or older than a month.

Exposure-response analysis of alectinib in crizotinib-resistant ALK-positive non-small cell lung cancer.

PubMed

Morcos, Peter N; Nueesch, Eveline; Jaminion, Felix; Guerini, Elena; Hsu, Joy C; Bordogna, Walter; Balas, Bogdana; Mercier, Francois

2018-05-10

Alectinib is a selective and potent anaplastic lymphoma kinase (ALK) inhibitor that is active in the central nervous system (CNS). Alectinib demonstrated robust efficacy in a pooled analysis of two single-arm, open-label phase II studies (NP28673, NCT01801111; NP28761, NCT01871805) in crizotinib-resistant ALK-positive non-small-cell lung cancer (NSCLC): median overall survival (OS) 29.1 months (95% confidence interval [CI]: 21.3-39.0) for alectinib 600 mg twice daily (BID). We investigated exposure-response relationships from final pooled phase II OS and safety data to assess alectinib dose selection. A semi-parametric Cox proportional hazards model analyzed relationships between individual median observed steady-state trough concentrations (C trough,ss ) for combined exposure of alectinib and its major metabolite (M4), baseline covariates (demographics and disease characteristics) and OS. Univariate logistic regression analysis analyzed relationships between C trough,ss and incidence of adverse events (AEs: serious and Grade ≥ 3). Overall, 92% of patients (n = 207/225) had C trough,ss data and were included in the analysis. No statistically significant relationship was found between C trough,ss and OS following alectinib treatment. The only baseline covariates that statistically influenced OS were baseline tumor size and prior crizotinib treatment duration. Larger baseline tumor size and shorter prior crizotinib treatment were both associated with shorter OS. Logistic regression confirmed no significant relationship between C trough,ss and AEs. Alectinib 600 mg BID provides systemic exposures at plateau of response for OS while maintaining a well-tolerated safety profile. This analysis confirms alectinib 600 mg BID as the recommended global dose for patients with crizotinib-resistant ALK-positive NSCLC.

Deglacial to Holocene history of ice-sheet retreat and bottom current strength on the western Barents Sea shelf

NASA Astrophysics Data System (ADS)

Lantzsch, Hendrik; Hanebuth, Till J. J.; Horry, Jan; Grave, Marina; Rebesco, Michele; Schwenk, Tilmann

2017-10-01

High-resolution sediment echosounder data combined with radiocarbon-dated sediment cores allowed us to reconstruct the Late Quaternary stratigraphic architecture of the Kveithola Trough and surrounding Spitsbergenbanken. The deposits display the successive deglacial retreat of the Svalbard-Barents Sea Ice Sheet. Basal subglacial till indicates that the grounded ice sheet covered both bank and trough during the Late Weichselian. A glaciomarine blanket inside the trough coinciding with laminated plumites on the bank formed during the initial ice-melting phase from at least 16.1 to 13.5 cal ka BP in close proximity to the ice margin. After the establishment of open-marine conditions at around 13.5 cal ka BP, a sediment drift developed in the confined setting of the Kveithola Trough, contemporary with crudely laminated mud, an overlying lag deposit, and modern bioclastic-rich sand on Spitsbergenbanken. The Kveithola Drift shows a remarkable grain-size coarsening from the moat towards the southern flank of the trough. This trend contradicts the concept of a separated drift (which would imply coarser grain sizes in proximity of the moat) and indicates that the southern bank is the main sediment source for the coarse material building up the Kveithola Drift. This depocenter represents, therefore, a yet undescribed combination of off-bank wedge and confined drift. Although the deposits inside Kveithola Trough and on Spitsbergenbanken display different depocenter geometries, time-equivalent grain-size changes imply a region-wide sediment-dynamic connection. We thus relate a phase of coarsest sediment supply (8.8-6.3 cal ka BP) to an increase in bottom current strength, which might be related to a stronger Atlantic Water inflow from the Southeast across the bank leading to winnowing and off-bank export of sandy sediments.

Tracking Boulders

NASA Technical Reports Server (NTRS)

2006-01-01

13 March 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a trough in the Sirenum Fossae region. On the floor and walls of the trough, large -- truck- to house-sized -- boulders are observed at rest. However, there is evidence in this image for the potential for mobility. In the central portion of the south (bottom) wall, a faint line of depressions extends from near the middle of the wall, down to the rippled trough floor, ending very near one of the many boulders in the area. This line of depressions is a boulder track; it indicates the path followed by the boulder as it trundled downslope and eventually came to rest on the trough floor. Because it is on Mars, even when the boulder is sitting still, this once-rolling stone gathers no moss.

Location near: 29.4oS, 146.6oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

Near-trench slip potential of megaquakes evaluated from fault properties and conditions

PubMed Central

Hirono, Tetsuro; Tsuda, Kenichi; Tanikawa, Wataru; Ampuero, Jean-Paul; Shibazaki, Bunichiro; Kinoshita, Masataka; Mori, James J.

2016-01-01

Near-trench slip during large megathrust earthquakes (megaquakes) is an important factor in the generation of destructive tsunamis. We proposed a new approach to assessing the near-trench slip potential quantitatively by integrating laboratory-derived properties of fault materials and simulations of fault weakening and rupture propagation. Although the permeability of the sandy Nankai Trough materials are higher than that of the clayey materials from the Japan Trench, dynamic weakening by thermally pressurized fluid is greater at the Nankai Trough owing to higher friction, although initially overpressured fluid at the Nankai Trough restrains the fault weakening. Dynamic rupture simulations reproduced the large slip near the trench observed in the 2011 Tohoku-oki earthquake and predicted the possibility of a large slip of over 30 m for the impending megaquake at the Nankai Trough. Our integrative approach is applicable globally to subduction zones as a novel tool for the prediction of extreme tsunami-producing near-trench slip. PMID:27321861

Laser welding on trough panel: 3D body part

NASA Astrophysics Data System (ADS)

Shirai, Masato; Hisano, Hirohiko

2003-03-01

Laser welding for automotive bodies has been introduced mainly by European car manufacturers since more than 10 years ago. Their purposes of laser welding introduction were mainly vehicle performance improvement and lightweight. And laser welding was applied to limited portion where shapes of panels are simple and easy to fit welded flanges. Toyota also has introduced laser welding onto 3 dimensional parts named trough panel since 1999. Our purpose of the introduction was common use of equipment. Trough panel has a complex shape and different shapes in each car type. In order to realize common use of welding equipment, we introduced parts locating equipment which had unique, small & simple jigs fo each car type and NC (Numerical Controlled) locators and air-cooled small laser head developed by ourselves to the trough welding process. Laser welding replaced spot welding and was applied linearly like stitches. Length of laser welding was determined according to comparison with statistic tensile strength and fatigue strength of spot welding.

Microtopographic characterization of ice-wedge polygon landscape in Barrow, Alaska: a digital map of troughs, rims, centers derived from high resolution (0.25 m) LiDAR data

DOE Data Explorer

Gangodagamage, Chandana; Wullschleger, Stan

2014-07-03

The dataset represents microtopographic characterization of the ice-wedge polygon landscape in Barrow, Alaska. Three microtopographic features are delineated using 0.25 m high resolution digital elevation dataset derived from LiDAR. The troughs, rims, and centers are the three categories in this classification scheme. The polygon troughs are the surface expression of the ice-wedges that are in lower elevations than the interior polygon. The elevated shoulders of the polygon interior immediately adjacent to the polygon troughs are the polygon rims for the low center polygons. In case of high center polygons, these features are the topographic highs. In this classification scheme, both topographic highs and rims are considered as polygon rims. The next version of the dataset will include more refined classification scheme including separate classes for rims ad topographic highs. The interior part of the polygon just adjacent to the polygon rims are the polygon centers.

The evolution of modern cosmology as seen through a personal walk across six decades

NASA Astrophysics Data System (ADS)

Narlikar, Jayant V.

2018-02-01

This highly personal account of evolution of cosmology spans a period of approximately six decades 1959-2017. It begins when in 1959 the author, as an undergraduate at Cambridge, was attracted to the subject by the thought provoking lectures by Fred Hoyle as well as by his popular books The Nature of Universe and The Frontiers of Astronomy. The result was that after a successful performance at the Mathematical Tripos (Part III) examination, he enrolled as a research student of Hoyle. In this article the author describes the interesting works in cosmology that kept him busy both in Cambridge and in India. The issues pertinent to cosmological research in the 1960s and 1970s included the Mach's principle, the Wheeler-Feynman theory relating the local electromagnetic arrow of time to the cosmological one, the observational tests of specific expanding universe models, and issues like singularity in quantum cosmology. However, post-1965, the nature of cosmological research changed dramatically with the discovery of the cosmic microwave background radiation (CMBR). Given the assumption that the CMBR is a relic of big bang there has been a host of papers on the early universe, going as close to the big bang as the very early universe would permit: around just 10-36 s. The author argues that despite the popularity of the standard hot big bang cosmology (SBBC) it rests on rather shaky foundations. On the theoretical side there is no well established physical framework to support the SBBC; nor is there independent observational support for its assumptions like the nonbaryonic dark matter, inflation and dark energy. While technological progress has made it possible to explore the universe in greater detail with open mind, today's cosmologists seem caught in a range of speculations in support of the big bang dogma. Thus, in modern times cosmology appears to have lost the Camelot spirit encouraging adventurous studies of the unknown. A spirit of openness is advocated to restore cosmology to its rightful position as the flagship of astronomy.

The evolution of modern cosmology as seen through a personal walk across six decades

NASA Astrophysics Data System (ADS)

Narlikar, Jayant V.

2018-05-01

This highly personal account of evolution of cosmology spans a period of approximately six decades 1959-2017. It begins when in 1959 the author, as an undergraduate at Cambridge, was attracted to the subject by the thought provoking lectures by Fred Hoyle as well as by his popular books The Nature of Universe and The Frontiers of Astronomy. The result was that after a successful performance at the Mathematical Tripos (Part III) examination, he enrolled as a research student of Hoyle. In this article the author describes the interesting works in cosmology that kept him busy both in Cambridge and in India. The issues pertinent to cosmological research in the 1960s and 1970s included the Mach's principle, the Wheeler-Feynman theory relating the local electromagnetic arrow of time to the cosmological one, the observational tests of specific expanding universe models, and issues like singularity in quantum cosmology. However, post-1965, the nature of cosmological research changed dramatically with the discovery of the cosmic microwave background radiation (CMBR). Given the assumption that the CMBR is a relic of big bang there has been a host of papers on the early universe, going as close to the big bang as the very early universe would permit: around just 10-36 s. The author argues that despite the popularity of the standard hot big bang cosmology (SBBC) it rests on rather shaky foundations. On the theoretical side there is no well established physical framework to support the SBBC; nor is there independent observational support for its assumptions like the nonbaryonic dark matter, inflation and dark energy. While technological progress has made it possible to explore the universe in greater detail with open mind, today's cosmologists seem caught in a range of speculations in support of the big bang dogma. Thus, in modern times cosmology appears to have lost the Camelot spirit encouraging adventurous studies of the unknown. A spirit of openness is advocated to restore cosmology to its rightful position as the flagship of astronomy.

Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases.

PubMed

Dreesen, Erwin; Verstockt, Bram; Bian, Sumin; de Bruyn, Magali; Compernolle, Griet; Tops, Sophie; Noman, Maja; Van Assche, Gert; Ferrante, Marc; Gils, Ann; Vermeire, Séverine

2018-04-25

Trough concentrations of vedolizumab were found to correlate with clinical response in phase 3 studies of patients with ulcerative colitis (UC) or Crohn's disease (CD). Nevertheless, there are no solid data to support monitoring of vedolizumab trough concentrations in treated patients. We investigated the correlation between vedolizumab exposure and response in a real-world population and aimed to identify patient factors that affect exposure and response. We performed a retrospective cohort study of 179 consecutive patients (66 with UC and 113 with CD) who began vedolizumab therapy from September 1, 2015, through October 1, 2016, at University Hospitals Leuven, Belgium. Serum concentrations of vedolizumab were measured before all infusions up to week 30. Effectiveness endpoints included endoscopic healing (UC, Mayo endoscopic sub-score ≤1; CD, absence of ulcers), clinical response (physicians' global assessment), and biologic response or remission (based on level of C-reactive protein) and were assessed at week 14 (for patients with UC) and week 22 (for patients with CD). A stepwise forward addition-backward elimination modeling approach was performed to identify factors independently associated with vedolizumab exposure and response. Vedolizumab trough concentrations >30.0 μg/mL at week 2, >24.0 μg/mL at week 6, and >14.0 μg/mL during maintenance therapy associated with a higher probability of attaining the effectiveness endpoints for patients with UC or CD (P < .05). Higher body mass and more severe disease (based on high level of C-reactive protein and low level of albumin and/or hemoglobin) at the start of vedolizumab therapy associated with lower trough concentrations of vedolizumab over the 30-week period and a lower probability of achieving mucosal healing (P < .05). Mucosal healing was achieved in significantly more patients with UC than patients with CD, even though a diagnosis of UC was not an independent predictor of higher vedolizumab trough concentrations. In a retrospective study of 179 patients with CD or UC, we observed a correlation between vedolizumab exposure and response. These findings support monitoring of vedolizumab trough concentrations to predict patients' outcome. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

Adalimumab for Treatment of Noninfectious Uveitis: Immunogenicity and Clinical Relevance of Measuring Serum Drug Levels and Antidrug Antibodies.

PubMed

Cordero-Coma, Miguel; Calleja-Antolín, Sara; Garzo-García, Irene; Nuñez-Garnés, Ana M; Álvarez-Castro, Carolina; Franco-Benito, Manuel; Ruiz de Morales, Jose G

2016-12-01

To evaluate the rate of immunogenicity induced by adalimumab and its relationship with drug serum levels and clinical responses in patients with noninfectious uveitis. Prospective observational study. Consecutive patients from 1 referral center who initiated treatment with adalimumab for active noninfectious uveitis resistant to conventional therapy. All patients received 40 mg adalimumab every other week. Patients were evaluated clinically and immunologically before and after 4, 8, and 24 weeks of treatment. Clinical evaluation included assessment of changes in visual acuity, degree of inflammation in the anterior chamber and vitreous cavity, central macular thickness, and retinal angiographic leakage. Immunologic evaluation included assessment of serum trough adalimumab and antibodies against adalimumab (AAA) levels and class II HLA typing. Twenty-five patients were enrolled. Overall, 18 of 25 patients (72%) showed a favorable clinical response to adalimumab therapy. Eleven patients (44%) achieved a complete response and 7 (28%) achieved a partial response. However, 7 of 25 patients (28%) were considered nonresponders. Median trough adalimumab serum levels were higher in responders than in nonresponders (P < 0.001). We observed AAA positivity (AAA+) at least 1 time point in 8 of 25 patients (32%), including 4 with transitory AAA and 4 with permanent AAA. In all patients with permanent AAA+, trough adalimumab levels became undetectable (P < 0.001). However, in patients who demonstrated transitory AAA+, no correlation was observed between AAA titers and adalimumab trough levels (P = 0.2).Concomitant immunosuppression did not show any protective effect on adalimumab immunogenicity in our cohort. An association between the presence of AAA+ and a worse uveitis outcome was observed only in patients with permanent AAA+, which correlated with undetectable adalimumab trough levels (P = 0.014). Treatment of noninfectious uveitis with adalimumab is associated with high rates of favorable clinical response. Overall, adalimumab trough levels were higher in responder patients. Development of permanent AAA was associated with undetectable trough adalimumab levels and worse uveitis outcome. Immunogenicity was more common in patients in whom uveitis was associated with a systemic disease and was not influenced by concomitant immunosuppressors. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Preliminary report, cruises L1-86-NC and L2-86-NC, Escanaba Trough, Gorda Ridge

USGS Publications Warehouse

Morton, J.L.; Normark, W.R.; Ross, Stephanie L.; Koski, R.A.; Holmes, M.L.; Shanks, Wayne C.; Zierenberg, R.A.; Lyle, M.W.; Benninger, L.M.

1987-01-01

Eight large (up to 200 m across) and many small massive sulfide deposits were photographed and sampled at the sediment-covered Escanaba Trough, southern Gorda Ridge, during S.P. Lee cruises L1-86-NC and L2-86-NC in 1986. The deposits are associated with two volcanic edifices within the sedimentary fill along the axis of Escanaba Trough. The sulfide and other hydrothermal minerals are deposited on the seafloor as well as within the sedimentary section. High concentrations of Pb and As in some of the sulfide samples indicates significant interaction between hydrothermal fluids and sediment at depth.

Sedimentation, volcanism, and ancestral lakes in the Valles Marineris: Clues from topography

NASA Technical Reports Server (NTRS)

Lucchitta, B. K.; Isbell, N. K.; Howington-Kraus, A.

1993-01-01

Compilation of a simplified geologic/geomorphic map onto a digital terrain model of Valles Marineris has permitted quantitative evaluations of topographic parameters. The study showed that, if their interior layered deposits are lacustrine, the ancestral Valles Marineris must have consisted of isolated basins. If, on the other hand, the troughs were interconnected as they are today, the deposits are most likely to volcanic origin, and the mesas in the peripheral troughs may be table mountains. The material eroded from the trough walls was probably not sufficient to form all of the interior layered deposits, but it may have contributed significantly to their formation.

Identification of Risk Factors for Nephrotoxicity in Patients Receiving Extended-Duration, High-Trough Vancomycin Therapy

PubMed Central

Contreiras, Claire; Legal, Michael; Lau, Tim T Y; Thalakada, Rosanne; Shalansky, Stephen; Ensom, Mary H H

2014-01-01

Background: In the past, impurities in vancomycin formulations were thought to contribute to nephrotoxicity. In contrast, when current, purer formulations are dosed at conventional trough levels (i.e., 5–15 mg/L), the incidence of nephrotoxicity is relatively low. Recent guidelines have recommended targeting higher vancomycin trough levels in treatment of complicated methicillin-resistant Staphylococcus aureus infections. Dosing based on these higher trough levels may be associated with nephrotoxicity, so the potential risk factors for vancomycin-associated nephrotoxicity require clearer definition. Objectives: To determine the occurrence of nephrotoxicity in patients receiving more than 7 days of vancomycin therapy with high trough levels (15–20 mg/L) and to identify and evaluate specific risk factors related to development of vancomycin-associated nephrotoxicity (i.e., serum creatinine ≥ 44.2 μmol/L or increase ≥ 50% [i.e., ≥ 26.2 μmol/L] from baseline on 2 consecutive days). Methods: Health care records were reviewed for patients seen at 2 major teaching hospitals between January 2008 and March 2011. Patients who had attained high trough levels of vancomycin were screened for eligibility. Patients with unstable renal function, those undergoing hemodialysis, and those for whom dosage and/or sampling times were unclear were excluded. Univariate and multivariate analyses were performed to identify risk factors associated with nephrotoxicity. Univariate variables with p < 0.1 were included in the logistic regression model. Results: Of the 176 patients with high trough levels included in the analysis, 24 (14%) experienced nephrotoxicity. In univariate analysis, admission to a general medicine unit (the setting of care for 16 [67%] of the 24 patients with nephrotoxicity) and extended duration of vancomycin treatment were identified as risk factors for nephrotoxicity (p < 0.1). Other risk factors included gastrointestinal comorbidity (p = 0.056), malignancy (p = 0.044), and febrile neutropenia (p = 0.032). Multivariate analysis identified treatment on general medicine units and treatment courses longer than 7 days as independent predictors of vancomycin-associated nephrotoxicity. Conclusion: Patients being treated on general medicine units and those receiving vancomycin for more than 7 days had an increased likelihood of experiencing nephrotoxicity. The increased risk for patients on general medicine units is likely multifactorial. The relationship between treatment duration and risk of nephrotoxicity appeared to be linear. When using extended-duration, high-trough vancomycin therapy, clinicians should be vigilant in monitoring for nephrotoxicity. PMID:24799722

Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity.

PubMed

Inciarte-Mundo, José; Ramirez, Julio; Hernández, Maria Victoria; Ruiz-Esquide, Virginia; Cuervo, Andrea; Cabrera-Villalba, Sonia Raquel; Pascal, Mariona; Yagüe, Jordi; Cañete, Juan D; Sanmarti, Raimon

2016-07-08

Serum levels of calprotectin, a major S100 leucocyte protein, are associated with disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients. Higher drug trough serum levels are associated with good response in patients treated with tumour necrosis factor inhibitors (TNFi). Power Doppler ultrasound (PDUS) synovitis is predictive of flare and progression of structural damage in patients in clinical remission. The purpose of this study was to analyse the accuracy of calprotectin and TNFi trough serum levels in detecting PDUS synovitis in RA and PsA patients in clinical remission or with low disease activity who were receiving TNFi. We conducted a cross-sectional study of 92 patients (42 with RA, 50 with PsA) receiving adalimumab (ADA), etanercept (ETN) or infliximab who were in remission or had low disease activity (28-joint Disease Activity Score based on erythrocyte sedimentation rate <3.2). Associations of calprotectin, TNFi trough serum levels and acute phase reactants with PDUS synovitis were assessed using correlation and linear regression analyses. The accuracy and discriminatory capacity in detecting PDUS synovitis was assessed using ROC curves. PDUS synovitis was found in 62.4 % of RA patients and 32 % of PsA patients. Both RA and PsA patients with PDUS synovitis had higher calprotectin levels and lower TNFi trough serum levels. Calprotectin positively correlated with ultrasound scores (all r coefficients >0.50 in RA). Calprotectin correlated with the PDUS synovitis score in patients treated with ADA and ETN. Using PDUS synovitis (yes or no) as the reference variable, calprotectin had an AUC of 0.826. The best cut-off was ≥1.66 μg/ml, with a likelihood ratio of 2.77. C-reactive protein (AUC 0.673) and erythrocyte sedimentation rate (AUC 0.731) had a lower discriminatory capacity. TNFi trough serum levels were significantly associated with PDUS synovitis (OR 0.67, 95 % CI 0.52-0.85, p < 0.001) but their accuracy (AUC <0.5) was less than that of calprotectin. TNFi trough serum levels were inversely correlated with calprotectin and PDUS synovitis in RA and PsA patients receiving ADA and ETN. Calprotectin and TNFi trough serum levels may help identify PDUS synovitis in RA and PsA patients in clinical remission or with low disease activity.

Convection and Easterly Wave Structure Observed in the Eastern Pacific Warm-Pool during EPIC-2001

NASA Technical Reports Server (NTRS)

Peterson, Walter A.; Cifelli, R.; Boccippio, D.; Rutledge, S. A.; Fairall, C. W.; Arnold, James E. (Technical Monitor)

2002-01-01

During September-October 2001, the East Pacific Investigation of Climate Processes in the Coupled Ocean-Atmosphere System (EPIC-2001) ITCZ field campaign focused on studies of deep convection in the warm-pool region of the East Pacific. In addition to the TAO mooring array, observational platforms deployed during the field phase included the NOAA ship RN Ronald H. Brown, the NSF ship RN Horizon, and the NOAA P-3 and NCAR C-130 aircraft. This study combines C-band Doppler radar, rawinsonde, and surface heat flux data collected aboard the RN Brown to describe ITCZ convective structure and rainfall statistics in the eastern Pacific as a function of 3-5 day easterly wave phase. Three distinct easterly wave passages occurred during EPIC-2001. Wind and thermodynamic data reveal that the wave trough axes exhibited positively correlated U and V winds and a slight westward phase tilt with height. A relatively strong (weak) northeasterly deep tropospheric shear followed the trough (ridge) axis. Temperature and humidity perturbations exhibited mid-to upper level cooling (warming) and drying (moistening) in the northerly (trough and southerly) phase. At low levels warming (cooling) occurred in the northerly (southerly) phase with little change in the relative humidity, though mixed layer mixing ratios were larger during the northerly phase. When composited, radar, sounding, lightning and surface heat flux observations suggest the following systematic behavior as a function of wave phase: approximately zero to one quarter wavelength ahead of (behind) the wave trough in northerly (southerly) flow, larger (smaller) CAPE, lower (higher) CIN, weaker (stronger) tropospheric shear, higher (lower) conditional mean rain rates, higher (lower) lightning flash densities, and more (less) robust convective vertical structure occurred. Latent and sensible heat fluxes reached a minimum in the northerly phase and then increased through the trough, reaching a peak during the ridge phase (leading the peak in CAPE). From a radar echo coverage perspective, larger areas of light rain and slightly larger (10%) area averaged rain rates occurred in the vicinity of, and just behind, the trough axes in southerly flow. Importantly, the transition in convective structure observed across the trough axis when considered with the relatively small change in area mean rain rates suggests the presence of a transition in the vertical structure of diabatic heating across the easterly waves examined. The inferred transition in heating structure is supported by radar diagnosed divergence profiles that exhibit convective (stratiform) characteristics ahead of (behind) the trough.

Cycling of sulfur in subduction zones: The geochemistry of sulfur in the Mariana Island Arc and back-arc trough

USGS Publications Warehouse

Alt, J.C.; Shanks, Wayne C.; Jackson, M.C.

1993-01-01

The sulfur contents and sulfur isotopic compositions of 24 glassy submarine volcanics from the Mariana Island Arc and back-arc Mariana Trough were determined in order to investigate the hypothesis that subducted seawater sulfur (??34S = 21???) is recycled through arc volcanism. Our results for sulfur are similar to those for subaerial arc volcanics: Mariana Arc glasses are enriched in 34S (??34S = up to 10.3???, mean = 3.8???) and depleted in S (20-290 ppm, mean = 100 ppm) relative to MORB (850 ppm S, ??34S = 0.1 ?? 0.5???). The back-arc trough basalts contain 200-930 ppm S and have ??34S values of 1.1 ?? 0.5???, which overlap those for the arc and MORB. The low sulfur contents of the arc and some of the trough glasses are attributed to (1) early loss of small amounts of sulfur through separation of immiscible sulfide and (2) later vapor-melt equilibrium control of sulfur contents and loss of sulfur in a vapor phase from sulfide-undersaturated melts near the minimum in sulfur solubility at f{hook}O2 ??? NNO (nickel-nickel oxide). Although these processes removed sulfur from the melts their effects on the sulfur isotopic compositions of the melts were minimal. Positive trends of ??34S with 87Sr 86Sr, LILE and LREE contents of the arc volcanics are consistent with a metasomatic seawater sulfur component in the depleted sub-arc mantle source. The lack of a 34S-rich slab signature in the trough lavas may be attributed to equilibration of metasomatic fluid with mantle material along the longer pathway from the slab to the source of the trough volcanics. Sulfur is likely to have been transported into the mantle wedge by metasomatic fluid derived from subducted sediments and pore fluids. Gases extracted from vesicles in arc and back-arc samples are predominantly H2O, with minor CO2 and traces of H2S and SO2. CO2 in the arc and back-arc rocks has ??13C values of -2.1 to -13.1???, similar to MORB. These data suggest that degassing of CO2 could explain the slightly lower ??13C values for some Mariana Trough volcanic glasses, and that incorporation of subduction-derived organic carbon into the Mariana Trough mantle source may not be necessary. More analyses are required to resolve this question, however. ?? 1993.

Impact of changes to policy for Mexican risk travel on Canadian blood donor deferrals.

PubMed

O'Brien, Sheila F; Uzicanin, Samra; Choquet, Karine; Yi, Qi-Long; Fan, Wenli; Goldman, Mindy

2013-10-01

Travel to malaria risk areas such as Mexico is a common source of donor deferral in Canada. On February 21st, 2011 the deferrable regions in Mexico were revised to permit donation if donors travelled to the state of Quintana Roo, Mexico, a popular ocean-side resort area. Canadian travel data and malaria deferral rates since 2007 were plotted to examine trends. Deferral records in one centre were accessed from January to April, 2011 to tabulate travel destinations of deferred donors immediately before and after the change. Travel to Mexico and the Caribbean accounts for 63% of general population travel, and travel to Mexico has been increasing (P <0.05). Deferral for short-term malaria risk travel has a strong seasonal trend with peaks in the winter and troughs in the summer. Approximately 36,000 fewer donations were lost following the change, a reduction of 37% from the previous year. Deferrals in one centre increased for Caribbean/Central America after the change (P <0.05) consistent with the seasonal trend, but decreased for Mexico (P <0.05). Deferrals for malaria risk travel are substantial. Careful revision and refinement of risk areas of travel can significantly reduce the burden of deferral.

Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored

PubMed Central

López, René; Arriagada, Elizabeth; Carrasco, René; Gallardo, Natalia; Lorca, Eduardo

2017-01-01

Background. Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. Methods. Forty-one stable Prograf (Astellas) receiving kidney transplant patients were switched to a generic tacrolimus (Sandoz) in a 1 : 1 dose ratio and were followed up for up to 8 months. All other drugs were maintained as per normal practice. Results. Neither tacrolimus doses nor their trough blood levels changed significantly after the switch, but serum creatinine did: 1.62 ± 0.90 versus 1.75 ± 0.92 mg/dL (p < 0.001). At the same time, five graft biopsies were performed, and two of them showed cellular acute rejection. There were nine infectious episodes treated satisfactorily with proper therapies. No patient or graft was lost during the follow-up time period. Conclusion. Switching from brand name tacrolimus to a generic tacrolimus (Sandoz) is feasible and appears to be safe, but it must be monitored carefully by treating physicians. PMID:28246556

Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored.

PubMed

González, Fernando; López, René; Arriagada, Elizabeth; Carrasco, René; Gallardo, Natalia; Lorca, Eduardo

2017-01-01

Background . Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. Methods . Forty-one stable Prograf (Astellas) receiving kidney transplant patients were switched to a generic tacrolimus (Sandoz) in a 1 : 1 dose ratio and were followed up for up to 8 months. All other drugs were maintained as per normal practice. Results . Neither tacrolimus doses nor their trough blood levels changed significantly after the switch, but serum creatinine did: 1.62 ± 0.90 versus 1.75 ± 0.92 mg/dL ( p < 0.001). At the same time, five graft biopsies were performed, and two of them showed cellular acute rejection. There were nine infectious episodes treated satisfactorily with proper therapies. No patient or graft was lost during the follow-up time period. Conclusion . Switching from brand name tacrolimus to a generic tacrolimus (Sandoz) is feasible and appears to be safe, but it must be monitored carefully by treating physicians.

Coastal submergence at Ukishima-ga-hara adjacent to the Suruga Trough (eastern Nankai Trough), central Japan, inferred from diatoms and plant macrofossils

NASA Astrophysics Data System (ADS)

Sawai, Y.; Momohara, A.

2017-12-01

Five episodic submergence events during the past 3500 years were recognized at the Ukishima-ga-hara lowland, northern coast of Suruga Trough (eastern Nankai Trough). Coastal submergence in this region was originally reported by Osamu Fujiwara and his colleagues (e.g., Fujiwara et al., 2016) based mainly on changes in lithostratigraphy from a peaty layer that abruptly changed to a light-colored mud and results of microfossil analyses (pollen and diatoms from 57 and 13 samples, respectively). They attributed the submergence events to coseismic deformation associated with earthquakes in the Fujikawa-kako fault zone or Suruga Trough. Here I reevaluated the micropaleontology of this area using 200 samples from 15 cores to reconstruct the full history of coastal submergence during the last few thousand years. The submergence events were shown not by lithostratigraphy but clearly by changes in fossil diatom assemblages and plant macrofossils. For example, at about 2.3 m and 3.1 m below the ground surface, while aerophilic diatoms (such as Diadesmis contenta and Diploneis elliptica) dominate the underlying peaty layer, freshwater and brackish planktonic taxa (Aulacoseira and Thalassiosira) abound in the overlying layer. As many as five such changes in diatom assemblages were found in a 8-m core and radiocarbon ages constrain the age of the entire sequence to 3500 yr BP.

Role of CYP24A1, VDR and GC gene polymorphisms on deferasirox pharmacokinetics and clinical outcomes.

PubMed

Allegra, S; Cusato, J; De Francia, S; Arduino, A; Longo, F; Pirro, E; Massano, D; De Nicolò, A; Piga, A; D'Avolio, A

2018-05-22

β-Thalassemia patients develop deficiency in vitamin D absorption and liver hydroxylation, resulting in extremely low calcitriol levels. We explored the role of single-nucleotide polymorphisms (SNPs) involved in vitamin D metabolism, transport and activity on deferasirox pharmacokinetics and outcomes (effectiveness trough levels (C trough ) and the area under the curve (AUC) cutoffs of 20 μg ml -1 and 360 μg ml -1  h -1 , respectively; nonresponse AUC limit of 250 μg ml -1  h -1 ). Ninety-nine β-thalassemic patients were enrolled. Drug plasma C trough and AUC were measured by the high-performance liquid chromatography system coupled with an ultraviolet determination method. Allelic discrimination for VDR, CYP24A1, CYP27B1 and GC gene SNPs was performed by real-time PCR. CYP24A1 22776 TT significantly influenced C min and negatively predicted it in regression analysis. CYP24A1 3999 CC was associated with C trough and C min and was a negative predictor of T max , whereas CYP24A1 8620 GG seemed to have a role in C trough , AUC, t 1/2 and C min , and was an AUC negative predictor factor. Considering treatment outcome, Cdx2 and GC 1296 were retained in regression analysis as AUC efficacy cutoff negative predictors.

Hydrogeologic Appraisal of the Valley-Fill Aquifer in the Port Jervis Trough, Sullivan and Ulster Counties, New York

USGS Publications Warehouse

Reynolds, Richard J.

2007-01-01

The nature and extent of valley-fill aquifers in the Port Jervis Trough was evaluated for a 16 mile section of this valley from the Orange-Sullivan County line near Westbrookville to the village of Napanoch in Ulster County as part of the U.S. Geological Survey's Detailed Aquifer Mapping Program in New York State. The principal aquifer in the Port Jervis Trough is a 50 feet thick outwash aquifer that extends from the Phillipsport Moraine near Summitville, southward through the study area to Port Jervis, N.Y. Previous studies had estimated as much as 500 feet of saturated drift in parts of the Trough, but new well data show that much of the valley fill consists of fine-grained lacustrine sediments. Drillers' logs show that the outwash aquifer south of Summitville is underlain by as much as 275 feet of lacustrine silt and clay. North of the Phillipsport Moraine, three large glaciolacustrine deltas that were built into Glacial Lake Wawarsing provide some local and discontinuous confined aquifers through their coarser bottomset beds. Elsewhere in the Trough, collapsed and buried portions of kame deltas and terraces provide local confined aquifers. The outwash aquifer appears to be very transmissive, as evidenced by the high specific capacity of 130 gallons per minute per foot [(gal/min)/ft] of a commercial test well screened in the aquifer.

Amplification of drawdown and runup over Hawaii's insular shelves by tsunami N-waves from mega Aleutian earthquakes

NASA Astrophysics Data System (ADS)

Bai, Yefei; Yamazaki, Yoshiki; Cheung, Kwok Fai

2018-04-01

The latest tsunami evacuation maps of Hawaii include an extreme scenario triggered by an Mw 9.3 Aleutian earthquake with large near-trench rupture. The tectonic plate motion produces concentrated seafloor uplift toward the deepest part of the trench generating a tsunami with strong non-hydrostatic characters. A parametric study shows the skewed seafloor uplift produces a dispersive leading crest followed by a prominent trough in the form of an N-wave. The trough maintains its depth across the ocean in the absence of side lobes and dispersion. Shifting of the uplift toward the trench tends to deepen the trough, but has diminishing effects on the wave crest away from the source. While the attenuated leading crest produces relatively moderate runup on north-facing shores of the Hawaiian Islands, with matching of the N-wave and shelf resonance periods, the trough produces an impulsive drawdown followed by an energetic upswing with unprecedented runup for a far-field tsunami. A set of control computations without dispersion reaffirms that a non-hydrostatic model is essential to account for these complex wave processes from the source to the shore. This case study highlights the unique tsunami hazards posed by the Aleutians to Hawaii and the role of wave troughs in delineating the impacts for hazard assessment and engineering design.

Seismic stratigraphic architecture of the Disko Bay trough-mouth fan system, West Greenland

NASA Astrophysics Data System (ADS)

Hofmann, Julia C.; Knutz, Paul C.

2015-04-01

Spatial and temporal changes of the Greenland Ice Sheet on the continental shelf bordering Baffin Bay remain poorly constrained. Then as now, fast-flowing ice streams and outlet glaciers have played a key role for the mass balance and stability of polar ice sheets. Despite their significance for Greenland Ice Sheet dynamics and evolution, our understanding of their long-term behaviour is limited. The central West Greenland margin is characterized by a broad continental shelf where a series of troughs extend from fjords to the shelf margin, acting as focal points for trough-mouth fan (TMF) accummulations. The sea-ward bulging morphology and abrupt shelf-break of these major depositional systems is generated by prograding depocentres that formed during glacial maxima when ice streams reached the shelf edge, delivering large amounts of subglacial sediment onto the continental slope (Ó Cofaigh et al., 2013). The aim of this study is to unravel the seismic stratigraphic architecture and depositional processes of the Disko Bay TMF, aerially the largest single sedimentary system in West Greenland, using 2D and 3D seismic reflection data, seabed bathymetry and stratigraphic information from exploration well Hellefisk-1. The south-west Disko Bay is intersected by a deep, narrow trough, Egedesminde Dyb, which extends towards the southwest and links to the shallower and broader cross-shelf Disko Trough (maximum water depths of > 1000 m and a trough length of c. 370 km). Another trough-like depression (trough length of c. 120 km) in the northern part of the TMF, indicating a previous position of the ice stream, can be distinguished on the seabed topographic map and the seismic images. The Disko Bay TMF itself extends from the shelf edge down to the abyssal plain (abyssal floor depths of 2000 m) of the southern Baffin Bay. Based on seismic stratigraphic configurations relating to reflection terminations, erosive patterns and seismic facies (Mitchum et al., 1977), the TMF succession has been divided into five seismic units, each representing different stages in the progradational accumulation of the TMF system. This poster and ongoing study will discuss how the ice-stream flow switching is linked to changes in depocentres of sedimentary sequences and further investigate the major controls, e.g. ice-sheet dynamics, ocean-climate changes, tectonic forcing and subglacial geology, that determined the evolution of the Disko Bay TMF. Essencial bibliography Mitchum, R.M. Jr., Vail, P.R., Sangree, J.B., 1977. Seismic stratigraphy and global changes of sea level, Part 6: Stratigraphic interpretation of seismic reflection patterns in depositional sequences. AAPG Memoir 26, 117-133. Ó Cofaigh, C., Andrews, J.T., Jennings, A.E., Dowdeswell, J.A., Hogan, K.A., Kilfeather, A.A., Sheldon, C., 2013. Glacimarine lithofacies, provenance and depositional processes on a West Greenland trough-mouth fan. Journal of Quaternary Science, 28(1), 13-26.

Recognition and characterization of networks of water bodies in the Arctic ice-wedge polygonal tundra using high-resolution satellite imagery

NASA Astrophysics Data System (ADS)

Skurikhin, A. N.; Gangodagamage, C.; Rowland, J. C.; Wilson, C. J.

2013-12-01

Arctic lowland landscapes underlain by permafrost are often characterized by polygon-like patterns such as ice-wedge polygons outlined by networks of ice wedges and complemented with polygon rims, troughs, shallow ponds and thermokarst lakes. Polygonal patterns and corresponding features are relatively easy to recognize in high spatial resolution satellite imagery by a human, but their automated recognition is challenging due to the variability in their spectral appearance, the irregularity of individual trough spacing and orientation within the patterns, and a lack of unique spectral response attributable to troughs with widths commonly between 1 m and 2 m. Accurate identification of fine scale elements of ice-wedge polygonal tundra is important as their imprecise recognition may bias estimates of water, heat and carbon fluxes in large-scale climate models. Our focus is on the problem of identification of Arctic polygonal tundra fine-scale landscape elements (as small as 1 m - 2 m width). The challenge of the considered problem is that while large water bodies (e.g. lakes and rivers) can be recognized based on spectral response, reliable recognition of troughs is more difficult. Troughs do not have unique spectral signature, their appearance is noisy (edges are not strong), their width is small, and they often form connected networks with ponds and lakes, and thus they have overlapping spectral response with other water bodies and surrounding non-water bodies. We present a semi-automated approach to identify and classify Arctic polygonal tundra landscape components across the range of spatial scales, such as troughs, ponds, river- and lake-like objects, using high spatial resolution satellite imagery. The novelty of the approach lies in: (1) the combined use of segmentation and shape-based classification to identify a broad range of water bodies, including troughs, and (2) the use of high-resolution WorldView-2 satellite imagery (with resolution of 0.6 m) for this identification. The approach starts by segmenting water bodies from an image, which are then categorized using shape-based classification. Segmentation uses combination of pan sharpened multispectral bands and is based on the active contours without edges technique. The segmentation is robust to noise and can detect objects with weak boundaries that is important for extraction of troughs. We then categorize the segmented regions via shape based classification. Because segmentation accuracy is the main factor impacting the quality of the shape-based classification, for segmentation accuracy assessment we created reference image using WorldView-2 satellite image of ice-wedge polygonal tundra. Reference image contained manually labelled image regions which cover components of drainage networks, such as troughs, ponds, rivers and lakes. The evaluation has shown that the approach provides a good accuracy of segmentation and reasonable classification results. The overall accuracy of the segmentation is approximately 95%, the segmentation user's and producer's accuracies are approximately 92% and 97% respectively.

Last deglaciation of the Svalbard/Barents Sea Ice Sheet - a swath bathymetric and sub-bottom seismic study from the Kveithola Trough

NASA Astrophysics Data System (ADS)

Rebesco, Michele; Liu, Yanguang; Camerlenghi, Angelo; Winsborrow, Monica; Sverre Laberg, Jan; Caburlotto, Andrea; Diviacco, Paolo; Accettella, Daniela; Sauli, Chiara; Wardell, Nigel

2010-05-01

Kveithola Trough, an E-W trending cross-shelf glacial trough in the NW Barents Sea, was surveyed for the first time during the EGLACOM cruise between 8th July and 4th August 2008 on board R/V OGS-Explora. EGLACOM (Evolution of a GLacial Arctic COntinental Margin: the southern Svalbard ice stream-dominated sedimentary system) project is the Italian contribution to the International Polar Year (IPY) Activity 367 (Neogene ice streams and sedimentary processes on high- latitude continental margins - NICE STREAMS). Such IPY activity included as well the Spanish SVAIS 2008 cruise on board BIO Hesperides. EGLACOM data acquisition, focused on the Storfjorden Fan and Kveithola Trough, included a multi-channel seismic (MCS) reflection survey and the simultaneous collection of swath bathymetry and sub-bottom CHIRP profiles. Swath bathymetry in the Kveithola Trough shows that the seafloor is characterized by E-W trending mega-scale glacial lineations (MSGL). These include large-scale ridges about 2 km wide and 15 m high as well as smaller grooves about 100 m wide and a few metres deep. Such MSGL record the fast flow of an ice stream draining the Svalbard/Barents Sea Ice Sheet (SBSIS) during the Last Glacial Maximum (LGM). MSGL are overprinted by transverse sediment ridges about 15 km apart which give rise to a staircase long profile of the trough. Such transverse ridges are interpreted as grounding-zone wedges (GZW) formed by deposition of unconsolidated, saturated subglacial till during ice stream retreat. Sub-bottom (CHIRP) and multi-channel reflection seismic data show that the morphology is controlled by stacked sets of lensoidal transparent units (tills) overlain by a draping glaciomarine unit up to over 15 m thick. Formed during temporary stillstands in grounding-zone position before complete deglaciation, GZW ridges are diagnostic of episodic retreat. Our data allow the reconstruction of deglaciation in the Spitsbergen Bank area, with each stage during deglaciation recorded by deposition of a GZW. Three independent lines of reasoning suggest that an ice cap persisted on Spitsbergen Bank for some thousand years and lasted much longer than those that fed the adjacent glacial troughs: 1) the freshness of the morphology in Kveithola Trough compared to that of adjacent Storfjorden and Bear Island troughs; 2) the volume of sediment in the GZW ridges compared to the small catchment area; 3) preliminary assessment of the stratigraphic position of debris flow deposits on the continental slope. The 15 m of sedimentary drape deposited on top of GZW ridges contains a high-resolution palaeoclimatic record of the last thousand years, which accumulated at a very high average sedimentation rate. Sampling (through drilling) of the thin glaciomarine sediments between the till lenses of the successive GZW ridges may allow the dating of deglaciation phases in the Barents Sea.

Aerial mulching techniques-trough fire

Treesearch

Robert Faust

2008-01-01

The Trough fire occurred in August 2001 on the Mendocino National Forest of northern California. A burned area emergency rehabilitation team evaluated the fire effects on the watershed. Concerns were soil from the denuded slopes moving into streams affecting fishery values, reservoir sedimentation and storm runoff plugging culverts leading to road wash outs. Past...

Strawberry Production in Soilless Substrate Troughs – Plant Growth

USDA-ARS?s Scientific Manuscript database

Soilless substrates made of peat moss, coconut coir, perlite, rockwool or bark are pathogen free and they have been used in strawberry production in Europe in troughs or containers. Open field strawberry production in soilless substrate is new to California growers. The objective of this study was t...

OUT Success Stories: Solar Trough Power Plants

DOE R&D Accomplishments Database

Jones, J.

2000-08-01

The Solar Electric Generating System (SEGS) plants use parabolic-trough solar collectors to capture the sun's energy and convert it to heat. The SEGS plants range in capacity from 13.8 to 80 MW, and they were constructed to meet Southern California Edison Company's periods of peak power demand.

Geohydrology of the stratified-drift aquifer system in the lower Sixmile Creek and Willseyville Creek trough, Tompkins County, New York

USGS Publications Warehouse

Miller, Todd S.; Karig, Daniel E.

2010-01-01

In 2002, the U.S. Geological Survey, in cooperation with the Tompkins County Planning Department began a series of studies of the stratified-drift aquifers in Tompkins County to provide geohydrologic data for planners to develop a strategy to manage and protect their water resources. This aquifer study in lower Sixmile Creek and Willseyville Creek trough is the second in a series of aquifer studies in Tompkins County. The study area is within the northern area of the Appalachian Plateau and extends about 9 miles from the boundary between Tompkins County and Tioga County in the south to just south of the City of Ithaca in the north. In lower Sixmile Creek and Willseyville Creek trough, confined sand and gravel aquifers comprise the major water-bearing units while less extensive unconfined units form minor aquifers. About 600 people who live in lower Sixmile Creek and Willseyville Creek trough rely on groundwater from the stratified-drift aquifer system. In addition, water is used by non-permanent residents such as staff at commercial facilities. The estimated total groundwater withdrawn for domestic use is about 45,000 gallons per day (gal/d) or 0.07 cubic foot per second (ft3/s) based on an average water use of 75 gal/d per person for self-supplied water systems in New York. Scouring of bedrock in the preglacial lower Sixmile Creek and Willseyville Creek valleys by glaciers and subglacial meltwaters truncated hillside spurs, formed U-shaped, transverse valley profiles, smoothed valley walls, and deepened the valleys by as much as 300 feet (ft), forming a continuous trough. The unconsolidated deposits in the study area consist mostly of glacial drift, both unstratified drift (till) and stratified drift (laminated lake, deltaic, and glaciofluvial sediments), as well as some post-glacial stratified sediments (lake-bottom sediments that were deposited in reservoirs, peat and muck that were deposited in wetlands, and alluvium deposited by streams). Multiple advances and retreats of the ice in the study area resulted in several sequences of various types of glacial deposits. A large moraine (Valley Heads Moraine) dominates the southern part of the study area, a large delta dominates the central part, and ground moraine (mostly till) dominates the northern part. Glacial sediments in the center of the lower Sixmile Creek and Willseyville Creek trough typically range from 150 to 200 ft but can be greater than 300 ft in some places. Where the sediments are composed of sand and gravel they form aquifers. In most parts of the lower Sixmile Creek and Willseyville Creek trough, there is an upper and a basal confined aquifer. However, underlying the central parts of the Brooktondale delta, there are as many as four confined aquifers, whereas in the northern part of the study area, only one extensive confined aquifer is present. The major sources of recharge to these confined aquifers are (1) direct infiltration of precipitation where confined aquifers crop out at land surface (mostly along the western trough wall in the southern and central parts of the study area and, to a lesser degree, along the eastern trough wall); (2) unchanneled surface and subsurface runoff from adjacent upland areas that seeps into the aquifer along the western trough walls; (3) subsurface flow from underlying till or bedrock at the lateral contacts at trough walls; (4) adjacent fine-grained stratified drift, especially when the aquifer is pumped; and (5) discharge from bedrock at the bottom and sides of the trough. In the central part of the study area, the surficial coarse-grained sediments (sand and gravel) comprise a delta near Brooktondale and form a small unconfined aquifer (0.3 square mile). Although much of the upper part of the delta has been removed by several aggregate mining operations, sufficient amounts of sand and gravel remain in most places to form a thin unconfined aquifer. The major sources of recharge to the unconfined aquifer are (1)

Charging machine

DOEpatents

Medlin, John B.

1976-05-25

A charging machine for loading fuel slugs into the process tubes of a nuclear reactor includes a tubular housing connected to the process tube, a charging trough connected to the other end of the tubular housing, a device for loading the charging trough with a group of fuel slugs, means for equalizing the coolant pressure in the charging trough with the pressure in the process tubes, means for pushing the group of fuel slugs into the process tube and a latch and a seal engaging the last object in the group of fuel slugs to prevent the fuel slugs from being ejected from the process tube when the pusher is removed and to prevent pressure liquid from entering the charging machine.

Peak Measurement for Vancomycin AUC Estimation in Obese Adults Improves Precision and Lowers Bias.

PubMed

Pai, Manjunath P; Hong, Joseph; Krop, Lynne

2017-04-01

Vancomycin area under the curve (AUC) estimates may be skewed in obese adults due to weight-dependent pharmacokinetic parameters. We demonstrate that peak and trough measurements reduce bias and improve the precision of vancomycin AUC estimates in obese adults ( n = 75) and validate this in an independent cohort ( n = 31). The precision and mean percent bias of Bayesian vancomycin AUC estimates are comparable between covariate-dependent ( R 2 = 0.774, 3.55%) and covariate-independent ( R 2 = 0.804, 3.28%) models when peaks and troughs are measured but not when measurements are restricted to troughs only ( R 2 = 0.557, 15.5%). Copyright © 2017 American Society for Microbiology.

Variations of the ionospheric plasma concentration in the region of the main ionospheric trough during the magnetic storm of December 18-19, 1978, in connection with measurements of the interplanetary magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gdalevich, G.L.; Afonin, V.V.; Eliseev, A.Y.

1986-07-01

Data from the Kosmos-900 satellite are used to examine variations of the ion concentration in the region of the main ionospheric trough at altitudes of about 500 km during the storm of December 18-19, 1978. These variations of ion densities are compared with the variations of the parameters of the interplanetary medium, in particular, with the E /sub y/ = -VB /sub z/ component of the interplanetary electric field. The results of the comparison are discussed. A scheme is proposed for the formation and motion of the trough during magnetic disturbances.

Thickness of surficial sediment at and near the Idaho National Engineering Laboratory, Idaho

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, S.R.; Liszewski, M.J.; Ackerman, D.J.

1996-06-01

Thickness of surficial sediment was determined from natural-gamma logs in 333 wells at and near the Idaho National Engineering Laboratory in eastern Idaho to provide reconnaissance data for future site-characterization studies. Surficial sediment, which is defined as the unconsolidated clay, silt, sand, and gravel that overlie the uppermost basalt flow at each well, ranges in thickness from 0 feet in seven wells drilled through basalt outcrops east of the Idaho Chemical Processing Plant to 313 feet in well Site 14 southeast of the Big Lost River sinks. Surficial sediment includes alluvial, lacustrine, eolian, and colluvial deposits that generally accumulated duringmore » the past 200 thousand years. Additional thickness data, not included in this report, are available from numerous auger holes and foundation borings at and near most facilities.« less

Design of a Field Raised-Bed Trough System using Soilless Substrates for Strawberry Production in California

USDA-ARS?s Scientific Manuscript database

There are a number of approaches for producing strawberry fruit on a commercial scale without fumigants. One possible approach is to grow strawberries using raised-bed troughs filled with non soil based substrate media. Field trials were conducted using peat, perlite, coir, rice hull, and a redwoo...

Concentrating Solar Power Projects - Chabei 64MW Molten Salt Parabolic

Science.gov Websites

project Status Date: September 29, 2016 Project Overview Project Name: Chabei 64MW Molten Salt Parabolic Technology: Parabolic trough Turbine Capacity: Net: 64.0 MW Gross: 64.0 MW Status: Under development Do you have more information, corrections, or comments? Background Technology: Parabolic trough Status: Under

Small mammals in oak woodlands in the Puget Trough, Washington.

Treesearch

S.M. Wilson; A.B. Carey

2001-01-01

We surveyed the 22 largest sites dominated by Oregon white oaks on the Fort Lewis Military Reservation, Washington, to determine small-mammal community structure and population abundances. Study areas were in the Puget Trough physiographic province and western hemlock vegetation zone. Most oak communities were ecotonal between prairie and Douglas-fir forest. Small...

Concentrating Solar Power Projects - Delingha 50MW Thermal Oil Parabolic

Science.gov Websites

Trough project | Concentrating Solar Power | NREL Delingha 50MW Thermal Oil Parabolic Trough project Status Date: April 17, 2017 Project Overview Project Name: Delingha 50MW Thermal Oil Parabolic Contractor: IDOM : Thermal energy storage system engineering Plant Configuration Solar Field # of Loops: 190

Concentrating Solar Power Projects - Urat Middle Banner 100MW Thermal Oil

Science.gov Websites

Parabolic Trough project | Concentrating Solar Power | NREL Middle Banner 100MW Thermal Oil Thermal Oil Parabolic Trough project Country: China Location: Urat Middle Banner (Inner Mongolia) Owner(s , 2017 Start Production: 2018 Participants Developer(s): Changzhou Royal Tech Solar Thermal Equipment Co

Concentrating Solar Power Projects - Rayspower Yumen 50MW Thermal Oil

Science.gov Websites

Trough project | Concentrating Solar Power | NREL Rayspower Yumen 50MW Thermal Oil Trough project Status Date: January 31, 2017 Project Overview Project Name: Rayspower Yumen 50MW Thermal Oil . Plant Configuration Solar Field Heat-Transfer Fluid Type: Thermal oil Power Block Turbine Capacity

Concentrating Solar Power Projects - Gulang 100MW Thermal Oil Parabolic

Science.gov Websites

Trough project | Concentrating Solar Power | NREL Gulang 100MW Thermal Oil Parabolic Trough project Status Date: September 29, 2016 Project Overview Project Name: Gulang 100MW Thermal Oil Parabolic ): Webmaster Solar Participants Developer(s): Changzhou Royal Tech Solar Thermal Equipment Co., Ltd. Owner(s

--No Title--

Science.gov Websites

SOUTHERN ROCKIES... A BROAD LONG WAVE TROUGH CROSSES THE CENTRAL AND SOUTHERN ROCKIES DURING DAY 1...BEFORE WEAKENING AND EXITING INTO THE PLAINS DURING DAY 2. SURFACE LOW PRESSURE FORMING IN RESPONSE TO THE MID MOST RECENT WPC QPF. DAY 1... LIFT ASSOCIATED WITH A BROAD POSITIVELY TILTED LONG WAVE TROUGH MOVING

SeaMARC II mapping of transform faults in the Cayman Trough, Caribbean Sea

USGS Publications Warehouse

Rosencrantz, Eric; Mann, Paul

1992-01-01

SeaMARC II maps of the southern wall of the Cayman Trough between Honduras and Jamaica show zones of continuous, well-defined fault lineaments adjacent and parallel to the wall, both to the east and west of the Cayman spreading axis. These lineaments mark the present, active traces of transform faults which intersect the southern end of the spreading axis at a triple junction. The Swan Islands transform fault to the west is dominated by two major lineaments that overlap with right-stepping sense across a large push-up ridge beneath the Swan Islands. The fault zone to the east of the axis, named the Walton fault, is more complex, containing multiple fault strands and a large pull-apart structure. The Walton fault links the spreading axis to Jamaican and Hispaniolan strike-slip faults, and it defines the southern boundary of a microplate composed of the eastern Cayman Trough and western Hispaniola. The presence of this microplate raises questions about the veracity of Caribbean plate velocities based primarily on Cayman Trough opening rates.

Ionospheric and magnetospheric plasmapauses'

NASA Technical Reports Server (NTRS)

Grebowsky, J. M.; Hoffman, J. H.; Maynard, N. C.

1977-01-01

During August 1972, Explorer 45 orbiting near the equatorial plane with an apogee of about 5.2 R sub e traversed magnetic field lines in close proximity to those simultaneously traversed by the topside ionospheric satellite ISIS 2 near dusk in the L range 2-5.4. The locations of the Explorer 45 plasmapause crossings during this month were compared to the latitudinal decreases of the H(+) density observed on ISIS 2 near the same magnetic field lines. The equatorially determined plasmapause field lines typically passed through or poleward of the minimum of the ionospheric light ion trough, with coincident satellite passes occurring for which the L separation between the plasmapause and trough field lines was between 1 and 2. Vertical flows of the H(+) ions in the light ion trough as detected by the magnetic ion mass spectrometer on ISIS were directed upward with velocities between 1 and 2 kilometers/sec near dusk on these passes. These velocities decreased to lower values on the low latitude side of the H(+) trough but did not show any noticeable change across the field lines corresponding to the magnetospheric plasmapause.

A survey of major east coast snowstorms, 1960-1983. Part 2. Summary of surface and upperlevel characteristics

NASA Technical Reports Server (NTRS)

Kocin, P. J.; Uccellini, L. W.

1985-01-01

Surface and upper-level characteristics of selected meteorological fields are summarized. Two major types of sea level development are described and applied to the cases at hand, with a few storm systems showing characteristics of both types. Aspects such as rapid sea level deepening, coastal frontogenesis, cold air damming, low level jet formation, the development of an S-shaped isotherm pattern, diffluence downwind of a negatively tilted upper level trough axis, upper level confluence and an increase of geopotential heights at the base of the upper level trough characterized the pre-cyclogenetic and cyclogenetic periods of many of the storm systems. Large variability was also observed, especially with regard to the spatial dimensions of the surface and upper level systems, as well as variations in trough/ridge amplification and the evolution of upper level jet streak systems. The influence of transverse circulations associated with a confluent jet streak entrance region and the diffluent exit region of a jet streak/trough system on the production of snowfall is also discussed.

Far-Field Noise Induced by Bubble near Free Surface

NASA Astrophysics Data System (ADS)

Ye, Xi; Li, Jiang-tao; Liu, Jian-hua; Chen, Hai-long

2018-03-01

The motion of a bubble near the free surface is solved by the boundary element method based on the linear wave equation, and the influence of fluid compressibility on bubble dynamics is analyzed. Based on the solution of the bubble motion, the far-field radiation noise induced by the bubble is calculated using Kirchhoff moving boundary integral equation, and the influence of free surface on far-field noise is researched. As the results, the oscillation amplitude of the bubble is weakened in compressible fluid compared with that in incompressible fluid, and the free surface amplifies the effect of fluid compressibility. When the distance between the bubble and an observer is much larger than that between the bubble and free surface, the sharp wave trough of the sound pressure at the observer occurs. With the increment of the distance between the bubble and free surface, the time of the wave trough appearing is delayed and the value of the wave trough increase. When the distance between the observer and the bubble is reduced, the sharp wave trough at the observer disappears.

Element for use in an inductive coupler for downhole drilling components

DOEpatents

Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Dahlgren, Scott; Fox, Joe; Sneddon, Cameron

2006-08-29

The present invention includes an element for use in an inductive coupler in a downhole component. The element includes a plurality of ductile, generally U-shaped leaves that are electrically conductive. The leaves are less than about 0.0625" thick and are separated by an electrically insulating material. These leaves are aligned so as to form a generally circular trough. The invention also includes an inductive coupler for use in downhole components, the inductive coupler including an annular housing having a recess with a magnetically conductive, electrically insulating (MCEI) element disposed in the recess. The MCEI element includes a plurality of segments where each segment further includes a plurality of ductile, generally U-shaped electrically conductive leaves. Each leaf is less than about 0.0625" thick and separated from the otherwise adjacent leaves by electrically insulating material. The segments and leaves are aligned so as to form a generally circular trough. The inductive coupler further includes an insulated conductor disposed within the generally circular trough. A polymer fills spaces between otherwise adjacent segments, the annular housing, insulated conductor, and further fills the circular trough.

Streamflow, water-quality, and biological conditions in the Big Black Creek basin, St. Clair County, Alabama, 1997

USGS Publications Warehouse

Journey, Celeste A.; Clark, Amy E.; Stricklin, Victor E.

1998-01-01

In 1997 synoptic streamflow, water-quality, and biological investi- gations in the Big Black Creek Basin were conducted by the U.S. Geological Survey in cooperation with the City of Moody, St. Clair County, and the Birmingham Water Works Board. Data obtained during these synoptic investigations provide a one-time look at the streamflow and water-quality conditions in the Big Black Creek Basin during a stable, base-flow period when streamflow originated only from ground-water discharge. These data were used to assess the degree of water-quality degradation in the Big Black Creek Basin from land-use activities in the basin, including leakage of leachate from the Acmar Regional Land- fill. Biological data from the benthic invertebrate community investigation provided an assessment of the cumulative effects of stream conditions on organisms in the basin. The synoptic measurement of streamflow at 28 sites was made during a period of baseflow on August 27, 1997. Two stream reaches above the landfill lost water to the ground-water system, but those below the landfill had significantly higher ground-water gains. If significant leakage of leachate from the landfill had occurred during the measurement period, the distribution of ground-water discharge suggests that leachate would travel relatively short distances before resurfacing as ground-water discharge to the stream. Benthic invertebrate communities were sampled at four sites in the Big Black Creek Basin during July 16-17, 1997. Based on Alabama Department of Environmental Management criteria and on comparison with a nearby unimparied reference site, the benthic invertebrate communities at the sites sampled were considered unimpaired or only slightly impaired during the sample period. This would imply that landfill and coal-mining activities did not have a detrimental effect on the benthic invertebrate communities at the time of the study. Synoptic water-column samples were collected at nine sites on Big Black Creek and its tributaries at the same time that the synoptic streamflow measurements were made. Trace-element and organic compound concentrations in the stream water were below established water-quality standards and criteria for the State of Alabama, with the exception of secondary (aesthetic) drinking-water levels for iron and manganese. Oil and grease concentrations detected in bed sediments were below the corrective action limit of 100 milligrams per kilogram. No significant increases in chloride, specific conductance, total dissolved solids, oil and grease, color, or biochemical oxygen demand were observed at sites downgradient from the landfill. Ground-water samples were collected from three drive-point wells in the vicinity of the landfill. These samples were analyzed for a suite of volatile organic compounds. The solvent 1,1-dichloroethane (the same solvent detected in the ground-water monitoring system at the landfill) was detected in a sample from a drive-point well downgradient from the landfill--an indication of the potential risk of landfill-derived contamination migrating toward Big Black Creek. No distinguishing trend or pattern of contamination was identified that could be attributed solely to landfill activities. Landfill activities did not appear to contribute significant contamination to Big Black Creek during these streamflow conditions. Any contaminant contribution from coal-mining activities in the basin may have served to mask any leachate contributions from the landfill; however, the overall effects on stream water and benthic intervebrate communities apparently were only minimal.

Hydrocarbon prospectivity assessment of the Southern Pattani Trough, Gulf of Thailand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mountford, N.

The Pattani Trough is an elongate north to south basin in the Gulf of Thailand offshore area that developed from Oligocene times onward. Numerous hydrocarbon discoveries, mainly gas, have been made within the Tertiary stratigraphic section in areas adjacent to the depocenter of the basin, but only dry holes have been drilled on the extreme basin margins and flanking platform areas. The southern Pattani Trough represents a [open quotes]transition zone[close quotes] in terms of potential hydrocarbon prospectivity between the low potential/high exploration risk basin marginal areas, and the high potential/low exploration risk basin marginal area. The development of hydrocarbon accumulationmore » potential within the southern Pattani Trough can be related to a number of major controlling factors. These include structure, which on a regional scale shows a marked influence of tectonic regime on depositional system development, and on a more local scale determines trap development; stratigraphy, which determines reservoir geometry and potential hydrocarbon source rock facies distribution; petrology, which exerts a major control on depth related reservoir quality; overpressure development, which controls local migration pathways for generated hydrocarbons, and locally provides very efficient trap seals; geochemical factors, related to potential source facies distribution, hydrocarbon type; and thermal maturation of the section. The above factors have been combined to define low-, medium-, and high-risk exploration [open quotes]play fairways[close quotes] within the prospectivity transition zone of the southern Pattani Trough.« less

Crustal structure and extension mode in the northwestern margin of the South China Sea

NASA Astrophysics Data System (ADS)

Gao, Jinwei; Wu, Shiguo; McIntosh, Kirk; Mi, Lijun; Liu, Zheng; Spence, George

2016-06-01

Combining multi-channel seismic reflection and gravity modeling, this study has investigated the crustal structure of the northwestern South China Sea margin. These data constrain a hyper-extended crustal area bounded by basin-bounding faults corresponding to an aborted rift below the Xisha Trough with a subparallel fossil ridge in the adjacent Northwest Sub-basin. The thinnest crust is located in the Xisha Trough, where it is remnant lower crust with a thickness of less than 3 km. Gravity modeling also revealed a hyper-extended crust across the Xisha Trough. The postrift magmatism is well developed and more active in the Xisha Trough and farther southeast than on the northwestern continental margin of the South China Sea; and the magmatic intrusion/extrusion was relatively active during the rifting of Xisha Trough and the Northwest Sub-basin. A narrow continent-ocean transition zone with a width of ˜65 km bounded seaward by a volcanic buried seamount is characterized by crustal thinning, rift depression, low gravity anomaly and the termination of the break-up unconformity seismic reflection. The aborted rift near the continental margin means that there may be no obvious detachment fault like that in the Iberia-Newfoundland type margin. The symmetric rift, extreme hyper-extended continental crust and hotter mantle materials indicate that continental crust underwent stretching phase (pure-shear deformation), thinning phase and breakup followed by onset of seafloor spreading and the mantle-lithosphere may break up before crustal-necking in the northwestern South China Sea margin.

Identification of large-scale meteorological patterns associated with extreme precipitation in the US northeast

NASA Astrophysics Data System (ADS)

Agel, Laurie; Barlow, Mathew; Feldstein, Steven B.; Gutowski, William J.

2018-03-01

Patterns of daily large-scale circulation associated with Northeast US extreme precipitation are identified using both k-means clustering (KMC) and Self-Organizing Maps (SOM) applied to tropopause height. The tropopause height provides a compact representation of the upper-tropospheric potential vorticity, which is closely related to the overall evolution and intensity of weather systems. Extreme precipitation is defined as the top 1% of daily wet-day observations at 35 Northeast stations, 1979-2008. KMC is applied on extreme precipitation days only, while the SOM algorithm is applied to all days in order to place the extreme results into the overall context of patterns for all days. Six tropopause patterns are identified through KMC for extreme day precipitation: a summertime tropopause ridge, a summertime shallow trough/ridge, a summertime shallow eastern US trough, a deeper wintertime eastern US trough, and two versions of a deep cold-weather trough located across the east-central US. Thirty SOM patterns for all days are identified. Results for all days show that 6 SOM patterns account for almost half of the extreme days, although extreme precipitation occurs in all SOM patterns. The same SOM patterns associated with extreme precipitation also routinely produce non-extreme precipitation; however, on extreme precipitation days the troughs, on average, are deeper and the downstream ridges more pronounced. Analysis of other fields associated with the large-scale patterns show various degrees of anomalously strong moisture transport preceding, and upward motion during, extreme precipitation events.

Optimized molten salt receivers for ultimate trough solar fields

NASA Astrophysics Data System (ADS)

Riffelmann, Klaus-J.; Richert, Timo; Kuckelkorn, Thomas

2016-05-01

Today parabolic trough collectors are the most successful concentrating solar power (CSP) technology. For the next development step new systems with increased operation temperature and new heat transfer fluids (HTF) are currently developed. Although the first power tower projects have successfully been realized, up to now there is no evidence of an all-dominant economic or technical advantage of power tower or parabolic trough. The development of parabolic trough technology towards higher performance and significant cost reduction have led to significant improvements in competitiveness. The use of molten salt instead of synthetic oil as heat transfer fluid will bring down the levelized costs of electricity (LCOE) even further while providing dispatchable energy with high capacity factors. FLABEG has developed the Ultimate TroughTM (UT) collector, jointly with sbp Sonne GmbH and supported by public funds. Due to its validated high optical accuracy, the collector is very suitable to operate efficiently at elevated temperatures up to 550 °C. SCHOTT will drive the key-innovations by introducing the 4th generation solar receiver that addresses the most significant performance and cost improvement measures. The new receivers have been completely redesigned to provide a product platform that is ready for high temperature operation up to 550 °C. Moreover distinct product features have been introduced to reduce costs and risks in solar field assembly and installation. The increased material and design challenges incurred with the high temperature operation have been reflected in sophisticated qualification and validation procedures.

Large-Scale Meteorological Patterns Associated with Extreme Precipitation in the US Northeast

NASA Astrophysics Data System (ADS)

Agel, L. A.; Barlow, M. A.

2016-12-01

Patterns of daily large-scale circulation associated with Northeast US extreme precipitation are identified using both k-means clustering (KMC) and Self-Organizing Maps (SOM) applied to tropopause height. Tropopause height provides a compact representation of large-scale circulation patterns, as it is linked to mid-level circulation, low-level thermal contrasts and low-level diabatic heating. Extreme precipitation is defined as the top 1% of daily wet-day observations at 35 Northeast stations, 1979-2008. KMC is applied on extreme precipitation days only, while the SOM algorithm is applied to all days in order to place the extreme results into a larger context. Six tropopause patterns are identified on extreme days: a summertime tropopause ridge, a summertime shallow trough/ridge, a summertime shallow eastern US trough, a deeper wintertime eastern US trough, and two versions of a deep cold-weather trough located across the east-central US. Thirty SOM patterns for all days are identified. Results for all days show that 6 SOM patterns account for almost half of the extreme days, although extreme precipitation occurs in all SOM patterns. The same SOM patterns associated with extreme precipitation also routinely produce non-extreme precipitation; however, on extreme precipitation days the troughs, on average, are deeper and the downstream ridges more pronounced. Analysis of other fields associated with the large-scale patterns show various degrees of anomalously strong upward motion during, and moisture transport preceding, extreme precipitation events.

Comparison of the multi-scale features in two persistent heavy rainfall events in the middle and lower reaches of Yangtze River

NASA Astrophysics Data System (ADS)

Hui, Pinhong; Fang, Juan

2016-06-01

Two persistent heavy rainfall (PHR) events in the middle and lower reaches of Yangtze River (MLYR) occurring in June 1982 and 1998 are studied in this paper. Though both events happened in the Meiyu season, their large-scale background and developing processes were quite different. During the PHR event in 1982, the Lake Baikal area was occupied by a strong westerly trough and the western Pacific subtropical high (WPSH) was stronger and more westward-extending than the normal years. Under such a condition, the cold-dry air and warm-moist air were continuously transported to the MLYR and favored the PHR there. For the event in 1998, the WPSH was similar to that in 1982, while the westerly trough in the Lake Baikal area was comparatively weak and a shortwave trough situating in East China contributed to advect cold-dry air to the MLYR. It is found that the high-latitude trough was closely related to the 10-30-day low-frequency oscillation while the anomaly of WPSH was linked with the combined effect of both 30-60- and 10-30-day low-frequency oscillations in the PHR event in 1982. By contrast, the 60-day low-pass perturbation demonstrated positive impact on the westward extension of WPSH and development of the Baikal trough while the 30-60-day oscillation played a role in strengthening the shortwave trough in East China and the WPSH in the case of 1998. Though the low-latitude 30-60-day oscillations contributed to the intensification and westward extension of the WPSH in both PHR events, their evolution exhibited evident differences. In the 1982 case, the 30-60-day anomalies originated from the western Indian Ocean were much more like the Madden-Julian Oscillation, while its counterpart in the 1998 case was much more similar to the first mode of the boreal summer intraseasonal oscillation.

Late Weichselian ice-sheet dynamics and deglaciation history of the northern Svalbard margin

NASA Astrophysics Data System (ADS)

Fransner, O.; Noormets, R. R. N. N.; Flink, A.; Hogan, K.; Dowdeswell, J. A.; O'Regan, M.; Jakobsson, M.

2016-12-01

The glacial evolution of the northern Svalbard margin is poorly known compared with the western margin. Gravity cores, swath bathymetric, sub-bottom acoustic and 2D airgun data are used to investigate the Late Weichselian Svalbard-Barents Ice Sheet history on the northern Svalbard margin. Prograding sequences in Kvitøya and Albertini trough mouths (TMs) indicate ice streaming to the shelf edge multiple times during the Quaternary. While Kvitøya Trough has an associated trough-mouth fan (TMF), Albertini TM is cut back into the shelf edge. Down-faulted bedrock below Albertini TM suggests larger sediment accommodation space there, explaining the absence of a TMF. The bathymetry indicates that ice flow in Albertini Trough was sourced from Duvefjorden and Albertinibukta. Exposed crystalline bedrock likely kept the two ice flows separated before merging north of Karl XII-Øya. Subglacial landforms in Rijpfjorden and Duvefjorden indicate that both fjords accommodated northward-flowing ice streams during the LGM. The deeper fjord basin and higher elongation ratios of landforms in Duvefjorden suggest a more focused and/or larger ice flow there. Easily erodible sedimentary rocks are common in Duvefjorden, which may explain different ice flow dynamics in these fjords. Kvitøya TMF is flanked by gullies, probably formed through erosive downslope gravity flows triggered by sediment-laden meltwater during early deglaciation. Glacial landforms in Albertini Trough comprise retreat-related landforms indicating slow deglaciation. Iceberg scours in Albertini Trough suggest the importance of calving for mass-loss. Sets of De Geer moraines in Rijpfjorden imply that slow, grounded retreat continued in <210 m water depth. Lack of retreat-related landforms in deeper areas of Rijpfjorden and in Duvefjorden indicates floating glacier fronts influenced by calving. 14C ages suggest that deglaciation of inner Rijpfjorden and central Duvefjorden were complete before 10,434 cal a BP and 10,779 cal a BP respectively.

A Quasi-Experiment To Study the Impact of Vancomycin Area under the Concentration-Time Curve-Guided Dosing on Vancomycin-Associated Nephrotoxicity

PubMed Central

Finch, Natalie A.; Zasowski, Evan J.; Murray, Kyle P.; Mynatt, Ryan P.; Zhao, Jing J.; Yost, Raymond; Pogue, Jason M.

2017-01-01

ABSTRACT Evidence suggests that maintenance of vancomycin trough concentrations at between 15 and 20 mg/liter, as currently recommended, is frequently unnecessary to achieve the daily area under the concentration-time curve (AUC24) target of ≥400 mg · h/liter. Many patients with trough concentrations in this range have AUC24 values in excess of the therapeutic threshold and within the exposure range associated with nephrotoxicity. On the basis of this, the Detroit Medical Center switched from trough concentration-guided dosing to AUC-guided dosing to minimize potentially unnecessary vancomycin exposure. The primary objective of this analysis was to assess the impact of this intervention on vancomycin-associated nephrotoxicity in a single-center, retrospective quasi-experiment of hospitalized adult patients receiving intravenous vancomycin from 2014 to 2015. The primary analysis compared the incidence of nephrotoxicity between patients monitored by assessment of the AUC24 and those monitored by assessment of the trough concentration. Multivariable logistic and Cox proportional hazards regression examined the independent association between the monitoring strategy and nephrotoxicity. Secondary analysis compared vancomycin exposures (total daily dose, AUC, and trough concentrations) between monitoring strategies. Overall, 1,280 patients were included in the analysis. After adjusting for severity of illness, comorbidity, duration of vancomycin therapy, and concomitant receipt of nephrotoxins, AUC-guided dosing was independently associated with lower nephrotoxicity by both logistic regression (odds ratio, 0.52; 95% confidence interval [CI], 0.34 to 0.80; P = 0.003) and Cox proportional hazards regression (hazard ratio, 0.53; 95% CI, 0.35 to 0.78; P = 0.002). AUC-guided dosing was associated with lower total daily vancomycin doses, AUC values, and trough concentrations. Vancomycin AUC-guided dosing was associated with reduced nephrotoxicity, which appeared to be a result of reduced vancomycin exposure. PMID:28923869

Association of the clinical efficacy of vancomycin with the novel pharmacokinetic parameter area under the trough level (AUTL) in elderly patients with hospital-acquired pneumonia.

PubMed

Fukumori, S; Tsuji, Y; Mizoguchi, A; Kasai, H; Ishibashi, T; Iwamura, N; To, H

2016-08-01

The pharmacokinetic-pharmacodynamic parameter that best predicts the efficacy of vancomycin is the ratio of the area under the concentration versus time curve (AUC) to the minimum inhibitory concentration (MIC). A 24-h AUC (AUC24 )/MIC ratio ≥ 400 was recommended in an American consensus review, but vancomycin treatment occasionally fails despite maintenance of AUC24 /MIC ≥ 400. We evaluated the association between clinical efficacy of vancomycin and two novel pharmacokinetic parameters, the 'area under the trough level' (AUTL) and the 'area above the trough level' (AATL), in hospitalized elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. The subjects were hospitalized elderly patients who were administered vancomycin for treatment of MRSA pneumonia between 2006 and 2012 at Sasebo Chuo Hospital (Nagasaki, Japan). Pharmacokinetic parameters of vancomycin were estimated for each patient by Bayesian analysis using population pharmacokinetic parameters for Japanese patients. Based on the patient-specific parameters thus obtained, AUC24 values were calculated as the vancomycin dosage divided by vancomycin clearance. AUTL was calculated as the trough serum concentration multiplied by 24 h, whereas AATL was calculated by subtracting AUTL from AUC24 . Logistic regression analysis demonstrated that efficacy of vancomycin was more strongly associated with AUTL than AUC24 . The optimal cut-off value of AUTL was 331 μg∙h/mL, which means that the optimal cut-off value of the trough serum concentration was 13·8 μg/mL. Efficacy of vancomycin was associated with AUTL, a novel pharmacokinetic parameter. Determining the target AUTL or trough concentration may enhance the efficacy of vancomycin therapy in elderly patients with MRSA pneumonia. Given that nephrotoxicity may increase with a Ctrough in excess of 15 μg/mL, this level should ideally not be exceeded. © 2016 John Wiley & Sons Ltd.

Effect of raltegravir on the total and unintegrated proviral HIV DNA during raltegravir-based HAART.

PubMed

Nicastri, Emanuele; Tommasi, Chiara; Abbate, Isabella; Bonora, Stefano; Tempestilli, Massimo; Bellagamba, Rita; Viscione, Magdalena; Rozera, Gabriella; Gallo, Anna L; Ivanovic, Jelena; Amendola, Alessandra; Pucillo, Leopoldo; Di Perri, Giovanni; Capobianchi, Maria R; Narciso, Pasquale

2011-01-01

Raltegravir is the first approved antiretroviral able to prevent HIV genome integration into the host chromosomes. The aim of the study is to test if raltegravir plasma concentrations can be associated with proviral DNA decline during raltegravir-based salvage therapy. A total of 33 multidrug-resistant HIV-infected patients were enrolled in a longitudinal open-label pilot study and completed a 24-week follow-up. The CD4(+) T-cell count, plasma viral load, proviral HIV DNA and two-long-terminal repeat (2-LTR) circular forms were assessed at baseline, day 14, 30, 60, 90 and 180. The raltegravir trough concentration (C (trough)) was measured by HPLC-ultraviolet and patients were divided into two groups according to the median raltegravir C (trough). The mean±SD values of baseline HIV RNA, CD4(+) T-cell count and HIV DNA were 4.4±0.82 log copies/ml, 256±177 cells/mm(3) , and 2,668±4,721 copies/10(6) peripheral blood mononuclear cells, respectively. Despite a transient increase of total DNA at week 2, a marked proviral DNA decay (P=0.01) with an increase of the 2-LTR unintegrated/total DNA ratio (P=0.06) over time was observed. At univariate analysis, no correlation between raltegravir C(trough) and classical virological parameters was observed. Nevertheless, the decay of proviral HIV DNA was more pronounced in patients displaying C(trough)<158 ng/ml with respect to those with C(trough)>158 ng/ml (P=0.046). Successful raltegravir-based therapy produces a significant decline in proviral DNA and is associated with an increase of the unintegrated/total DNA ratio. Further studies are necessary to define the possible role of pharmacokinetic raltegravir monitoring and the biological meaning of unintegrated proviral DNA. © 2011 International Medical Press

A Quasi-Experiment To Study the Impact of Vancomycin Area under the Concentration-Time Curve-Guided Dosing on Vancomycin-Associated Nephrotoxicity.

PubMed

Finch, Natalie A; Zasowski, Evan J; Murray, Kyle P; Mynatt, Ryan P; Zhao, Jing J; Yost, Raymond; Pogue, Jason M; Rybak, Michael J

2017-12-01

Evidence suggests that maintenance of vancomycin trough concentrations at between 15 and 20 mg/liter, as currently recommended, is frequently unnecessary to achieve the daily area under the concentration-time curve (AUC 24 ) target of ≥400 mg · h/liter. Many patients with trough concentrations in this range have AUC 24 values in excess of the therapeutic threshold and within the exposure range associated with nephrotoxicity. On the basis of this, the Detroit Medical Center switched from trough concentration-guided dosing to AUC-guided dosing to minimize potentially unnecessary vancomycin exposure. The primary objective of this analysis was to assess the impact of this intervention on vancomycin-associated nephrotoxicity in a single-center, retrospective quasi-experiment of hospitalized adult patients receiving intravenous vancomycin from 2014 to 2015. The primary analysis compared the incidence of nephrotoxicity between patients monitored by assessment of the AUC 24 and those monitored by assessment of the trough concentration. Multivariable logistic and Cox proportional hazards regression examined the independent association between the monitoring strategy and nephrotoxicity. Secondary analysis compared vancomycin exposures (total daily dose, AUC, and trough concentrations) between monitoring strategies. Overall, 1,280 patients were included in the analysis. After adjusting for severity of illness, comorbidity, duration of vancomycin therapy, and concomitant receipt of nephrotoxins, AUC-guided dosing was independently associated with lower nephrotoxicity by both logistic regression (odds ratio, 0.52; 95% confidence interval [CI], 0.34 to 0.80; P = 0.003) and Cox proportional hazards regression (hazard ratio, 0.53; 95% CI, 0.35 to 0.78; P = 0.002). AUC-guided dosing was associated with lower total daily vancomycin doses, AUC values, and trough concentrations. Vancomycin AUC-guided dosing was associated with reduced nephrotoxicity, which appeared to be a result of reduced vancomycin exposure. Copyright © 2017 American Society for Microbiology.

NCAR CCM2 simulation of the modern Antarctic climate

NASA Technical Reports Server (NTRS)

Tzeng, Ren-Yow; Bromwich, David H.; Parish, Thomas R.; Chen, Biao

1994-01-01

The National Center for Atmospheric Research (NCAR) community climate model version 2 (CCM2) simulation of the circumpolar trough, surface air temperature, the polar vortex, cloudiness, winds, and atmospheric moisture and energy budgets are examined to validate the model's representation of the present-day Antarctic climate. The results show that the CCM2 can well simulate many important climate features over Antarctica, such as the location and intensity of the circumpolar trough, the coreless winter over the plateau, the intensity and horizontal distribution of the surface inversion, the speed and streamline pattern of the katabatic winds, the double jet stream feature over the southern Indian and Pacific oceans, and the arid climate over the continent. However, there are also some serious errors in the model. Some are due to old problems but some are caused by the new parameterizations in the model. The model errors over high southern latitudes can be summarized as follows: The circumpolar trough, the polar vertex, and the westerlies in midlatitudes are too strong; the semiannual cycle of the circumpolar trough is distorted compared to the observations; the low centers of the circumpolar trough and the troughs in the middle and upper troposphere are shifted eastward by 15 deg - 40 deg longitude; the surface temperatures are too cold over the plateau in summer and over the coastline in winter; the polar tropopause continues to have a cold bias; and the cloudiness is too high over the continent. These biases are induced by two major factors: (1) the cloud optical properties in tropical and middle latitudes, which cause the eastward shift of troughs and surface low centers and the error in the semiannual cycle, and (2) the cold bias of the surface air temperature, which is attributed to the oversimulation of cloudiness over the continent, especially during summer, and the uniform 2-m-thick sea ice. The constant thickness of sea ice suppresses the energy flux from the ocean to the atmosphere and hence reduces the air temperature near the coast during winter. Finally, although the simulated Antarctic climate still suffers these biases, the overall performance of the CCM2 is much better than that of the CCM1-T42. Therefore the CCM2 is good enough to be used for climate change studies, especially over Antarctica.

Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn's disease.

PubMed

Drobne, David; Bossuyt, Peter; Breynaert, Christine; Cattaert, Tom; Vande Casteele, Niels; Compernolle, Griet; Jürgens, Matthias; Ferrante, Marc; Ballet, Vera; Wollants, Willem-Jan; Cleynen, Isabelle; Van Steen, Kristel; Gils, Ann; Rutgeerts, Paul; Vermeire, Severine; Van Assche, Gert

2015-03-01

The addition of immunomodulators increases the efficacy of maintenance therapy with infliximab for up to 1 year in patients with Crohn's disease who have not been previously treated with immunomodulators. However, there are questions about the effect of withdrawing immunomodulator therapy from these patients. We studied the effects of treatment with infliximab and immunomodulators (co-treatment) and then immunomodulator withdrawal on long-term outcomes of patients, as well as trough levels of infliximab and formation of anti-infliximab antibodies (ATI). In a retrospective study with the median follow-up period of 34 months (interquartile range, 19-58 months), we analyzed data from 223 patients treated for Crohn's disease between May 1999 and December 2010 at the University Hospitals, Leuven, Belgium (65 received infliximab monotherapy, 158 received infliximab and an immunomodulator). Trough levels of infliximab and levels of ATI were measured in blood samples collected from 117 patients throughout co-treatment, as well as the time of immunomodulator withdrawal and after withdrawal. Patients receiving co-treatment had higher trough levels of infliximab (adjusted mean increase, 1.44-fold) than those receiving infliximab monotherapy (95% confidence interval [CI], 1.07-1.92; P = .02). A smaller percentage of patients receiving co-treatment developed ATI (35 of 158, 22%) than those receiving infliximab monotherapy (25 of 65, 38%; P = .01). Among co-treated patients, levels of infliximab remained stable after immunomodulators were withdrawn (before: 3.2 μg/mL; 95% CI, 1.6-5.8 μg/mL and after: 3.7 μg/mL; 95% CI, 1.3-6.3 μg/mL; P = .70). After withdrawal of immunomodulators, 45 of 117 patients (38%) required increasing doses of infliximab, and 21 of 117 (18%) discontinued infliximab. At the time of immunomodulator withdrawal, trough levels of infliximab and C-reactive protein were most strongly associated with response to infliximab thereafter. In a retrospective analysis, we confirmed that withdrawal of immunomodulators after at least 6 months (median, 13 months) of co-treatment with infliximab does not reduce the trough levels of infliximab in patients with Crohn's disease. Detectable trough levels of infliximab at the time of immunomodulator withdrawal are associated with long-term response. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Structural characteristics around the frontal thrust along the Nankai Trough revealed by bathymetric and seismic reflection survey

NASA Astrophysics Data System (ADS)

Yamashita, M.; Nakanishi, A.; Moore, G. F.; Kodaira, S.; Nakamura, Y.; Miura, S.; Kaneda, Y.

2016-12-01

Great earthquakes with tsunamis with recurrence intervals of 100-200 years have occurred along the Nankai Trough near central Japan where the Shikoku Basin is subducting with thick sediments on the Philippine Sea plate. To predict the exact height of the tsunami on the coast region generated by these large ruptures, it is important to estimate the vertical deformation that occurs on the seaward end of the rupture area. Recent drilling results have also yielded evidence not only of splay faults that generate tsunamigenic rupture, but also new evidence of tsunamigenic rupture along the frontal thrust at the trench axis in the Nankai Trough. In order to understand the deformation around the frontal thrust at the trench axis, we conducted a dense high-resolution seismic reflection survey with 10-20 km spacing over 1500 km of line length during 2013 and 2014. Clear seismic reflection images of frontal thrusts in the accretionary prism and subducting Shikoku Basin, image deformation along the trench axis between off Muroto Cape and off Ashizuri Cape. The cumulative displacement along the frontal thrust and second thrust are measured from picked distinct reflectors in depth-converted profiles. The average value of cumulative displacement of the frontal thrust is more than 100 m within 2 km depth beneath the seafloor. The location of highest displacement of 300 m displacement agree with the seaward end of slip distribution of the 1946 Nankai event calculated by numerical simulations. We also evaluate the seaward structure for understanding the future rupture distribution. The protothrust zone (PTZ) consisting of many incipient thrusts is identifiable in the portion of trough-fill sediments seaward of the frontal thrust. In order to emphasize the characteristics of frontal thrust and PTZ, we construct the detailed relief image for focusing on the lineated slope of the PTZ at the trough axis. Although our surveys covered a part of Nankai seismogenic zone, it is important to evaluate the initiation and evolution of frontal thrust at the toe of Nankai trough axis. This study is part of "Research project for compound disaster mitigation on the great earthquakes and tsunamis around the Nankai Trough region" funded by the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

Regional distribution of volcaniclastic layer and its implication for segmentation of the Nankai seismogenic zone

NASA Astrophysics Data System (ADS)

Sasaki, T.; Lim, J.; Higashi, M.; Park, J.

2010-12-01

The Nankai Trough is known as one of the best-suited convergent plate margins for studying accretionary prism growth as well as subduction zone earthquakes. Along the Nankai accretionary margin off southwest Japan, the Shikoku Basin which formed 26-15 Ma as backarc spreading in the Philippine Sea Plate is being subducted about 4 cm/year to the northwest. The Deep Sea Drilling Project (DSDP) and Ocean Drilling Program (ODP) penetrated the Nankai accretionary prism and the incoming sedimentary section along the Ashizuri and Muroto transects, off Shikoku Island. Also, Integrated Ocean Drilling Program (IODP), which represented just one part of a multi-stage project known as the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) has been conducting drilling cruises now. IODP Expedition 322 in 2009, the coring was carried out at two drilling sites on the northern part of the Shikoku Basin in the subducting Philippine Sea plate. One of the major achievements of Expedition 322 is a discovery of late Miocene (10.2-7.6 Ma) tuffaceous and volcaniclastic sandstone layer (Underwood et al., IODP Prel. Rept. 322, 2009) that has not been previously recognized in the Nankai Trough. Based on age and volcanic sand content analysis, these volcaniclastic layers were unique to the Shikoku Basin off Kii Peninsula. The closest source of this volcanic layer was supposed to be the Izu-Bonin arc. Subducted sediments ultimately affect subduction zone geochemistry, thermal structure, and seismogenesis. High porosity of the volcaniclastic sandstone layer suggests the transportation of fluid to the subduction zone, it might affect the initiation and evolution of the decollement zone or plate boundary fault in the Nankai Trough. We interpreted single channel and multichannel seismic reflection profiles that have been acquired in the Nankai Trough margin by Japan Agency for Marine-Earth Science and Technology (JAMSTEC) since the year of 1997. We tried to map the major seismic layers such as volcaniclastic layer, volcanic ash layer and turbidite layers which were found at drilling sites in the IODP Expedition 322 in the northern Shikoku Basin. As a result, we recognized that these prominent seismic layers are widely distributed in the northern Shikoku Basin. In this talk, we will show specific seismic layers directly connecting to the decollement at the Nankai Trough axis, and discuss its implications for subduction processes in the Nankai Trough margin.

Interplate locking derived from seafloor geodetic measurement at the shallow subduction zone of the northernmost Suruga Trough, Japan

NASA Astrophysics Data System (ADS)

Yasuda, K.; Tadokoro, K.; Ikuta, R.; Watanabe, T.; Nagai, S.; Sayanagi, K.

2013-12-01

Observation of seafloor crustal deformation is crucial for megathrust earthquake because most of the focal areas are located below seafloor. Seafloor crustal deformation can be observed GPS/Acoustic technique, and this technique has been carried out at subduction margins in Japan, e.g., Japan Trench, Suruga Trough, and Nankai Trough. At the present, the accuracy of seafloor positioning is one to several centimeters for each epoch. Velocity vectors at seafloor site are estimated through repeated observations. Co- and post- seismic slip distribution and interseismic deformation are estimated from results of seafloor geodetic measurement (e.g., Iinuma et al., 2012; Tadokoro et al., 2012). We repeatedly observed seafloor crustal deformations at two sites across the Suruga Trough from 2005 to investigate interplate locking condition at the focal area of the anticipated megathrust, Tokai, earthquake. We observed 12 and 16 times at an east site of the Suruga Trough (SNE) and at an west site of the Suruga Trough (SNW), respectively. We reinstalled seafloor benchmarks at both sites because of run out of batteries in 2012. We calculated and removed the bias between the old and new seafloor benchmarks. Furthermore, we evaluated two type of analysis. One is Fixed triangular configuration Analysis (FTA). When we determine the seafloor benchmark position, we fix the triangular configuration of seafloor units averaging all the measurements to improve trade-off relation between seafloor benchmark position and sound speed structure. Sound speed structure is assumed to be horizontal layered structure. The other one is Fixed Triangle and Gradient structure of sound speed structure (FTGA). We fixed triangular configuration same as FTA. Sound speed structure is assumed to have gradient structure. Comparing FTA with FTGA, the RMS of horizontal position analyzed through FTA is smaller than that through FTGA at SNE site. On the other hand, the RMS of horizontal position analyzed through FTA is larger than that through FTGA at SNW site. We estimated the displacement velocities with relative to the Amurian plate from the result of repeated observation. The estimated displacement velocity vectors at SNE and SNW are 42×8 mm/y to N94W direction and 46×13 mm/y to N77W direction, respectively. The directions are the same as those measured at the on-land GPS stations. The magnitudes of velocity vector indicate significant shortening by approximately 11 mm/y between SNW and on-land GPS stations at the western part of the Suruga Trough. We also calculated the theoretical surface deformation pattern to depict the interplate locking condition. These results show that the plate interface at the shallow zone of the northernmost Suruga trough is strongly locked.

Cycling of sulfur in subduction zones: The geochemistry of sulfur in the Mariana Island Arc and back-arc trough

NASA Astrophysics Data System (ADS)

Alt, Jeffrey C.; Shanks, Wayne C., III; Jackson, Michael C.

1993-10-01

The sulfur contents and sulfur isotopic compositions of 24 glassy submarine volcanics from the Mariana Island Arc and back-arc Mariana Trough were determined in order to investigate the hypothesis that subducted seawater sulfur (delta S-34 = 21 parts per thousand) is recycled through arc volcanism. Our results for sulfur are similar to those for subaerial arc volcanics: Mariana Arc glasses are enriched in S-34(delta S-34 = up to 10.3 parts per thousand, mean = 3.8 parts per thousand) and depleted in S(20-290 ppm, mean = 100 ppm) relative to mid ocean ridge basalt (MORB)(850 ppm S, delta S-34 = 0.1 +/- 0.5 parts per thousand). The bac-arc trough basalts contain 200-930 ppm S and have delta S-34 values of 1.1 +/- 0.5 parts per thousand, which overlap those for the arc and MORB. The low sulfur contents of the arc and some of the trough glasses are attributed to (1) early loss of small amounts of sulfur through separation of immiscible sulfide and (2) later vapor-melt equilibrium control of sulfur contents and loss of sulfur in a vapor phase from sulfide-undersaturated melts near the minimum in sulfur solubility at fO2 is approximately equal to NNO (nickel-nickel oxide). Although these processes removed sulfur from the melts their effects on the sulfur isotopic compositions of the melts were minimal. Positive trends of delta S-34 with Sr-87/Sr-86 large ion lithophile element (LILE) and Light rare earth elements (LREE) contents of the arc volcanics are consistent with a metasomatic seawater sulfur component in the depleted sub-arc mantle source. The lack of a S-34-rich slab signature in the trough lavas may be attributed to equilibration of metasomatic fluid with mantle material along the longer pathway from the slab to the source of the trough volcanics. Sulfur is likely to have been transported into the mantle wedge by metasomatic fluid derived from subducted sediments and pore fluids. Gases extracted from vesicles in arc and back-arc samples are predominantly H2O, with minor CO2 and traces of H2S and SO2.CO2 in the arc and back-arc rocks has delta C-13 values of -2.1 to 13.1 parts per thousand, similar to MORB. These data suggest that degassing of CO2 could explain the slightly lower delta C-13 values for some Mariana Trough volcanic glasses, and that incorporation of subduction-derived organic carbon into the Mariana trough mantle source may not be necessary. More analyses are required to resolve this question, however.

Potentiometric surfaces, summer 2013 and winter 2015, and select hydrographs for the Southern High Plains aquifer, Cannon Air Force Base, Curry County, New Mexico

USGS Publications Warehouse

Collison, Jake

2016-04-07

Cannon Air Force Base (Cannon AFB) is located in the High Plains physiographic region of east-central New Mexico, about 5 miles west of Clovis, New Mexico. The area surrounding Cannon AFB is primarily used for agriculture, including irrigated cropland and dairies. The Southern High Plains aquifer is the principal source of water for Cannon AFB, for the nearby town of Clovis, and for local agriculture and dairies. The Southern High Plains aquifer in the vicinity of Cannon AFB consists of three subsurface geological formations: the Chinle Formation of Triassic age, the Ogallala Formation of Tertiary age, and the Blackwater Draw Formation of Quaternary age. The Ogallala Formation is the main water-yielding formation of the Southern High Plains aquifer. Groundwater-supplied, center-pivot irrigation dominates pumping from the Southern High Plains aquifer in the area surrounding Cannon AFB, where the irrigation season typically extends from early March through October. The U.S. Geological Survey has been monitoring groundwater levels in the vicinity of Cannon AFB since 1954 and has developed general potentiometric-surface maps that show groundwater flow from northwest to southeast in the study area. While previous potentiometric-surface maps show the general direction of groundwater flow, a denser well network is needed to show details of groundwater flow at a local scale. Groundwater levels were measured in 93 wells during summer 2013 and 100 wells during winter 2015.The summer and winter potentiometric-surface maps display the presence of what is interpreted to be a groundwater trough trending from the northwest to the southeast through the study area. This groundwater trough may be the hydraulic expression of a Tertiary-age paleochannel. Groundwater north of the trough flows in a southerly direction into the trough, and groundwater south of the trough flows in an easterly direction into the trough.During the 18-month period between summer 2013 and winter 2015, changes in groundwater levels ranged from a rise of 10.0 to a decline of 3.8 feet. The regions to the north and south of the groundwater trough contained the majority of the rises in groundwater levels, whereas the regions within the trough contained the majority of the declines in groundwater levels. In contrast, the long-term groundwater-level trend in wells with 20 to 60 years of record is a steady decline in average annual water levels, with declines ranging from 0.41 to 2.81 feet per year. Overall, the northwestern part of the study area exhibits the smallest average annual declines, while the southeastern part of the study area exhibits the largest average annual declines.

Stability model and risk assessment for the Montescaglioso Landslide (Southern Italy)

NASA Astrophysics Data System (ADS)

Amanti, Marco; Chiessi, Vittorio; Guarino, Paolo Maria; Spizzichino, Daniele; Troccoli, Alessandro; Vizzini, Giorgio

2015-04-01

In this paper, we present the final results of a landslide risk assessment evaluation implemented for the recent Montescaglioso landslide emergency occurred on 3rd December 2013 when a large and rapid slope failure, triggered by prolonged and intense rainfall, affected a big portion of the SW slope of the village. The slope failure damaged a main road, private homes and commercial buildings. The Montescaglioso village (Basilicata Region, Italy) is located on the top of a conglomerate hill overlying a gentle slope constituted by Plio-Pleistocene clays. The area has been affected since ancient time by different landslide typologies and mechanism, as determined by a direct geomorphological survey and from mapping and available technical literature. Phenomena such as rock-falls and rock lateral spreading in the upper part of the hill, and rotational/translational slides and earth flows can be recognized in the area. Landslides are mainly promoted by the geological and structural setting of the area as well as by very low mechanical characteristics of sediments outcropping in the area. After the emergency phase, a detailed program of field survey and laboratory campaign has been implemented during the last year. A detailed topographical analysis has been developed by using the LIDAR survey in order to define morphometric conditions and geometry modifications of the slope affected by the landslide. Based on the studies carried out in the area, the research has been aimed to assessing the stability conditions (residual landslide risk) of the SW slope of the hill trough an extended geological, geomorphological and geotechnical campaign linked with numerical study of present instability mechanism. The geological and geotechnical model of the slope has been defined trough the analysis of the past and recent logs obtained from several boreholes and also through the results of many mechanical test performed on samples taken in the area. The numerical study has been carried out using two different commercial codes, the Differences Elements Flac ® and Finite Elements Phase2® in 2-Dimensional plain strain conditions, applied to a typical section extending along the slope. The geotechnical model has been calibrated trough a back analysis procedure of the December 2013 failure event. By adopting a reasonable hypothesis concerning the hydraulic conditions in the slope, this procedure allowed to reduce the mechanical parameter obtained during the geotechnical laboratory characterizations to the site scale. The numerical results stressed the influence of a pre existing deep potential failure surface able to trigger a phenomenon of the investigated magnitude. Monitoring data, which are currently in elaboration, are expected to integrate and enhance the understanding of instability mechanism affecting the Montescaglioso village. The reconstruction and modeling of the landslide evolution can be useful to suggest correct mitigation strategies that may help to prevent social and economic degradation of the territory

The Rome trough and evolution of the Iapetean margin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, D.; Hamilton-Smith, T.; Drahovzal, J.A.

1991-08-01

Recent structural mapping of the Rome trough suggests a complex structure very different from the symmetrical and laterally continuous graben commonly depicted. Early and Middle Cambrian extension in the Rome trough of eastern Kentucky and adjacent areas resulted in a series of alternately facing half-grabens with variable displacement. These half-grabens are bounded by southwest-northeast-trending normal faults (e.g., Kentucky River and Warfield faults), which are laterally continuous only on the order to tens of kilometers. The Rome trough is laterally segmented by north-south-trending faults (e.g., Lexington fault) commonly expressed as flexures in younger rocks (e.g., Burning Springs anticline and Floyd Countymore » channel). Many of these north-south-trending faults have significant left-lateral displacement, and probably represent reactivated thrust faults of the Grenville tectonic front. The Rome trough and the associated Mississippi Valley, Rough Creek, and Birmingham fault systems were initiated during an Early Cambrian shift in sea-floor spreading from the Blue Ridge-Pine Mountain rift to the Ouachita rift along the Alabama-Oklahoma transform fault. These fault systems have been proposed as having originated from extensional stress propagated northward from the Ouachita rift across the transform fault. In the alternate model proposed here, faulting was brittle, extensional failure resulting form subsidence and flexure of the continental margin to the east. Following initiation of sea-floor spreading at the Blue Ridge-Pine Mountain rift in the latest Proterozoic, margin subsidence in the presence of the Alabama-Oklahoma transform boundary and the inherited Grenville tectonic front resulted in this interior cratonic fault system.« less

Evidence for Recent Liquid Water on Mars: Gullies in Sirenum Fossae Trough

NASA Technical Reports Server (NTRS)

2000-01-01

This mosaic of two Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) images shows about 20 different gullies coming down the south-facing wall of a trough in the Sirenum Fossae/Gorgonum Chaos region of the martian southern hemisphere. Each channel and its associated fan--or apron--of debris appears to have started just below the same hard, resistant layer of bedrock located approximately 100 meters (about 325 feet) below the top of the trough wall. The layer beneath this hard, resistant bedrock is interpreted to be permeable, which allows ground water to percolate through it and--at the location of this trough--seep out onto the martian surface. The channels and aprons only occur on the south-facing slope of this valley created by faults on each side of the trough. The depression is approximately 1.4 km (0.9 mi) across.

The mosaic was constructed from two pictures taken on September 16, 1999, and May 1, 2000. The black line is a gap between the two images that was not covered by MOC. The scene covers an area approximately 5.5 kilometers (3.4 miles) wide by 4.9 km (3.0 mi) high. Sunlight illuminates the area from the upper left. The image is located near 38.5oS, 171.3oW. MOC high resolution images are taken black-and-white (grayscale); the color seen here has been synthesized from the colors of Mars observed by the MOC wide angle cameras and by the Viking Orbiters in the late 1970s.

Impact of Pharmacy Practice Model Expansion on Pharmacokinetic Services: Optimization of Vancomycin Dosing and Improved Patient Safety.

PubMed

Han, Zhe; Pettit, Natasha N; Landon, Emily M; Brielmaier, Benjamin D

2017-04-01

Background: The impact of pharmacy interventions on optimizing vancomycin therapy has been described, however interventions vary among studies and the most optimal pharmacy practice model (PPM) for pharmacokinetic (PK) services has not been established. Objective: The purpose of this study is to demonstrate the value of 24 hours a day, 7 days a week (24/7) PK services. Methods: New PK services were implemented in 2 phases with institutional PPM expansion. Phase 1 included universal monitoring by pharmacists with recommendations made to prescribers during business hours. Phase 2 expanded clinical pharmacists' coverage to 24/7 and provided an optional 24/7 pharmacist-managed PK consult service. We compared vancomycin therapeutic trough attainment, dosing, and clinical and safety outcomes between phases 1 and 2 in adult inpatients receiving therapeutic intravenous vancomycin. Results. One hundred and fifty patients were included in each phase. Phase 2 had a greater proportion of vancomycin courses with therapeutic initial trough concentrations (27.5% vs 46.1%; p = 0.002), higher initial trough concentrations (10.9 mcg/mL vs 16.4 mcg/mL; p < 0.001), and optimized initial vancomycin dosing (13.5 mg/kg vs 16.2 mg/kg; p < 0.001). Phase 2 also saw significant reduction in the incidence of vancomycin-associated nephrotoxicity (21.1% vs 11.7%; p = 0.038). Dose optimization and improvement in initial target trough attainment were most notable among intensive care unit (ICU) patients. Conclusions. Our study demonstrated that 24/7 PK services implemented with institutional PPM expansion optimized vancomycin target trough attainment and improved patient safety.

Synoptic patterns leading to hailstorm in Chaharmahal and Bakhtiari province, Iran

NASA Astrophysics Data System (ADS)

Salahi, Bromand; Nohegar, Ahmad; Behrouzi, Mahmoud; Aalijahan, Mehdi

2018-03-01

The purpose of this study was to extract the synoptic patterns of 500 mb geopotential height and the sea level pressure leading to form hail in Chaharmahal and Bakhtiari province, Iran. To this end, at first, we explored hail occurrence in different areas of the province under investigation. Then, using sea level pressure and 500 mb geopotential height data, the patterns of hail occurrence were investigated through hierarchical clustering and Ward's method. The level of 500 mb patterns resulting in hail formation in the area include: (1) settlement of a cut-off low pressure blocking in Turkey and Iran's position in downstream of trough and injection of humidity coming from the Red Sea; (2) settlement of low ridge in northern Europe and Iran lying in downstream of the trough and injection of humidity of the Mediterranean Sea; (3) settlement of a cut-off low pressure in east of Europe and Iran lying in downstream of the trough; and (4) settlement of a deep trough in the Mediterranean Sea, formation of an omega-shaped blocking in Northern Europe and Iran lying in downstream of the trough. At sea level, the following patterns have caused hail formation in Chaharmahal and Bakhtiari province: (1) settlement of low pressure in Iran and Russia accompanying high pressure in Taklimakan Desert and east of Europe; (2) settlement of low pressure in Iran and high pressure in Egypt, northern Europe, and Taklimakan Desert; and (3) settlement of low pressure in Iran, Saudi Arabia and south of Italy and high pressure in Egypt and Siberia.

Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids.

PubMed

Mourad, Michel; Mourad, Georges; Wallemacq, Pierre; Garrigue, Valérie; Van Bellingen, Christophe; Van Kerckhove, Valérie; De Meyer, Martine; Malaise, Jacques; Eddour, Djamila Chaib; Lison, Dominique; Squifflet, Jean Paul; Haufroid, Vincent

2005-10-15

CYP3A5 and MDR1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements. The aim is to determine whether these polymorphisms also affect sirolimus trough concentrations and dose requirements after kidney transplantation. Eighty-five renal transplant recipients receiving sirolimus were included. Twenty-four were treated with a combined sirolimus-tacrolimus regimen. Eighty-one patients received steroids. Sirolimus and tacrolimus were adjusted to a target therapeutic window. CYP3A5 (intron 3) and MDR1 (exons 12, 21, 26) genotypes were correlated to the adjusted trough concentrations and dose requirements for both sirolimus and tacrolimus. There were no significant correlation between adjusted sirolimus trough concentrations or dose requirements and genetic polymorphisms. In a multiple regression model, adjusted-prednisone dose was involved with a positive or negative effect when considering sirolimus dose requirements or adjusted concentrations, respectively. In the subgroup of patients treated by tacrolimus and sirolimus, adjusted tacrolimus doses were higher in patients carrying at least one CYP3A5 *1 allele (median 0.083 vs. 0.035 mg/kg for CYP3A5*3/*3 patients, P<0.05). Adjusted-prednisolone dose and CYP3A5 polymorphism explained up to 61% of the variability in tacrolimus dose requirements. Unlike tacrolimus, sirolimus adjusted trough concentrations and dose requirements seem not affected by CYP3A5 and MDR1 polymorphisms. Adjusted-prednisone dose has a significant impact on tacrolimus and sirolimus dose requirements.

Determining the Nature of Late Gunn–Peterson Troughs with Galaxy Surveys

NASA Astrophysics Data System (ADS)

Davies, Frederick B.; Becker, George D.; Furlanetto, Steven R.

2018-06-01

Recent observations have discovered long (up to ∼110 Mpc/h), opaque Gunn–Peterson troughs in the z ∼ 5.5 Lyα forest, which are challenging to explain with conventional models of the post-reionization intergalactic medium. Here, we demonstrate that observations of the galaxy populations in the vicinity of the deepest troughs can distinguish two competing models for these features: deep voids where the ionizing background is weak due to fluctuations in the mean free path of ionizing photons would show a deficit of galaxies, while residual temperature variations from extended, inhomogeneous reionization would show an overdensity of galaxies. We use large (∼550 Mpc/h) semi-numerical simulations of these competing explanations to predict the galaxy populations in the largest of the known troughs at z ∼ 5.7. We quantify the strong correlation of Lyα effective optical depth and galaxy surface density in both models, and estimate the degree to which realistic surveys can measure such a correlation. While a spectroscopic galaxy survey is ideal, we also show that a relatively inexpensive narrowband survey of Lyα-emitting galaxies is ∼90% likely to distinguish between the competing models.

Amazonian volcanism inside Valles Marineris on Mars

NASA Astrophysics Data System (ADS)

Brož, Petr; Hauber, Ernst; Wray, James J.; Michael, Gregory

2017-09-01

The giant trough system of Valles Marineris is one of the most spectacular landforms on Mars, yet its origin is still unclear. Although often referred to as a rift, it also shows some characteristics that are indicative of collapse processes. For decades, one of the major open questions was whether volcanism was active inside the Valles Marineris. Here we present evidence for a volcanic field on the floor of the deepest trough of Valles Marineris, Coprates Chasma. More than 130 individual edifices resemble scoria and tuff cones, and are associated with units that are interpreted as lava flows. Crater counts indicate that the volcanic field was emplaced sometime between ∼0.4 Ga and ∼0.2 Ga. The spatial distribution of the cones displays a control by trough-parallel subsurface structures, suggesting magma ascent in feeder dikes along trough-bounding normal faults. Spectral data reveal an opaline-silica-rich unit associated with at least one of the cones, indicative of hydrothermal processes. Our results point to magma-water interaction, an environment of astrobiological interest, perhaps associated with late-stage activity in the evolution of Valles Marineris, and suggest that the floor of Coprates Chasma is promising target for the in situ exploration of Mars.

A fixed collector employing reversible vee-trough concentrator and a vacuum tube receiver for high temperature solar energy systems

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1976-01-01

A solar heat collection system employing non-tracking reflectors integrated with a fixed vacuum tube receiver which achieves modest year-round concentration (about 2) of the sunlight at low capital costs is discussed. The axis of the vee-trough reflector lies in a east-west direction and requires reversal of the reflector surfaces only twice a year without disturbing the receiver tubes and associated plumbing. It collects most of the diffuse flux. The vacuum tube receiver with selective absorber has no convection losses while radiation and conduction losses are minimal. Significant cost reductions are offered since the vee-trough can be fabricated from inexpensive polished or plastic reflector laminated sheet metal covering 2/3 of the collection area, and only about 1/3 of the area is covered with the more expensive vacuum tube receivers. Thermal and economic performance of the vee-trough vacuum tube system, year-round variation of the concentration factor, incident flux, useful heat per unit area at various operation temperatures and energy cost estimates are presented. The electrical energy cost is estimated to be 77 mills/kWh, and the system construction cost is estimated to be $1140/kWe.

Analysis, development and testing of a fixed tilt solar collector employing reversible Vee-Trough reflectors and vacuum tube receivers

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1979-01-01

The Vee-Trough/Vacuum Tube Collector (VTVTC) aimed to improve the efficiency and reduce the cost of collectors assembled from evacuated tube receivers. The VTVTC was analyzed rigorously and a mathematical model was developed to calculate the optical performance of the vee-trough concentrator and the thermal performance of the evacuated tube receiver. A test bed was constructed to verify the mathematical analyses and compare reflectors made out of glass, Alzak and aluminized GEB Teflon. Tests were run at temperatures ranging from 95 to 180 C during the months of April, May, June, July and August 1977. Vee-trough collector efficiencies of 35-40 per cent were observed at an operating temperature of about 175 C. Test results compared well with the calculated values. Test data covering a complete day are presented for selected dates throughout the test season. Predicted daily useful heat collection and efficiency values are presented for a year's duration at operation temperatures ranging from 65 to 230 C. Estimated collector costs and resulting thermal energy costs are presented. Analytical and experimental results are discussed along with an economic evaluation.

Stratigraphic framework of Cambrian and Ordovician rocks in the central Appalachian Basin from Medina County, Ohio, through southwestern and south-central Pennsylvania to Hampshire County, West Virginia

USGS Publications Warehouse

Ryder, Robert T.; Harris, Anita G.; Repetski, John E.; revised and digitized by Crangle, Robert D.

2003-01-01

A 275-mi-long restored stratigraphic cross section from Medina County, Ohio, through southwestern and south-central Pennsylvania to Hampshire County, W. Va., provides new details on Cambrian and Ordovician stratigraphy in the central Appalachian basin and the structure of underlying Precambrian basement rocks. From west to east, the major structural elements of the block-faulted basement in this section are (1) the relatively stable, slightly extended craton, which includes the Wooster arch, (2) the fault-controlled Ohio-West Virginia hinge zone, which separates the craton from the adjoining Rome trough, (3) the Rome trough, which consists of an east-facing asymmetric graben and an overlying sag basin, and (4) a positive fault block, named here the South-central Pennsylvania arch, which borders the eastern margin of the graben part of the Rome trough. Pre-Middle Ordovician structural relief on Precambrian basement rocks across the down-to-the-west normal fault that separates the Rome trough and the adjoining South-central Pennsylvania arch amounted to between 6,000 and 7,000 ft. The restored cross section shows eastward thickening of the Cambrian and Ordovician sequence from about 3,000 ft near the crest of the Wooster arch at the western end of the section to about 5,150 ft at the Ohio-West Virginia hinge zone adjoining the western margin of the Rome trough to about 19,800 ft near the depositional axis of the Rome trough. East of the Rome trough, at the adjoining western edge of the South-central Pennsylvania arch, the Cambrian and Ordovician sequence thins abruptly to about 13,500 ft and then thins gradually eastward across the arch to about 12,700 ft near the Allegheny structural front and to about 10,150 ft at the eastern end of the restored section. In general, the Cambrian and Ordovician sequence along this section consists of four major lithofacies that are predominantly shallow marine to peritidal in origin. In ascending stratigraphic order, the lithofacies are identified by the following descriptive names: (1) sandstone, shale, limestone, and dolomite unit, (2) dolomite and sandstone unit, (3) limestone and black shale unit, and (4) shale and sandstone unit. Each of these units and their associated subunits thicken from west to east across the restored section to a maximum near the depositional axis of the Rome trough and then thin eastward to the end of the section. The sandstone, shale, limestone, and dolomite unit is largely confined to the asymmetric graben that marks the initial phase of the Rome trough. This unit is Early and Middle Cambrian in age and consists, in ascending order, of a basal sandstone unit (undrilled but probably present), the Tomstown Dolomite (undrilled but probably present), the Waynesboro Formation, and the Pleasant Hill Limestone and its equivalent lower one-third of the Elbrook Formation at the eastern end of the section. The dolomite and sandstone unit forms the core of the Cambrian and Ordovician sequence. In the Rome trough and on the adjoining South-central Pennsylvania arch, this unit consists, in ascending order, of the Middle and Upper Cambrian Warrior Formation and the equivalent upper two-thirds of the Elbrook Formation at the eastern end of the section, the Upper Cambrian Gatesburg Formation, and the Lower Ordovician and Middle Ordovician (Whiterockian and Chazyan) Beekmantown Group. West of the Ohio-West Virginia hinge zone, the dolomite and sandstone unit consists, in ascending order, of the Conasauga Formation of Janssens (1973), the Krysik sandstone of driller's usage, the B zone of Calvert (1964), the Knox Dolomite and the associated Rose Run Sandstone Member, and the Wells Creek Formation. The widespread Knox unconformity is located at the base of the Wells Creek Formation and at or near the top of the adjoining Beekmantown Group, except near the depositional axis of the Rome trough, where the unconformity seems to be absent. The limestone and black shale unit i

Are the dimensions of submarine lobe systems independent of allogenic factors?

NASA Astrophysics Data System (ADS)

Prélat, A.; Covault, J. A.; Hodgson, D. M.; Fildani, A.; Flint, S. S.

2010-05-01

Submarine lobe dimensions from six different systems are compared: 1) the exhumed Permian Fan 3 lobe complex of the Tanqua Karoo, South Africa; 2) the modern Amazon fan channel-mouth lobe complex, offshore Brazil; 3) a portion of the modern distal Zaïre fan, offshore Angola / Congo; 4) a Pleistocene fan of the Kutai Basin, subsurface offshore Indonesia; 5) the modern Golo system, offshore east Corsica, France; and 6) a lobe complex deposited in the shallow subsurface, offshore Nigeria. These six systems have significantly different source-to-sink configurations (shelf dimension and slope topography), sediment supply characteristics (calibre and rate), tectonic settings, (palaeo) latitude, and delivery systems. Despite these differences, the lobe deposits share similar geometric and dimensional characteristics. Lobes are grouped into two distinct populations of geometries that can be related to basin-floor topography. The first population corresponds to areally extensive but thin lobes (average width 14 km × length 35 km × thickness 12 m) that were deposited onto low relief basin floor areas, like the Tanqua Karoo, the Amazon and the Zaïre systems. The second population corresponds to areally smaller but thicker lobes (average width 5 km × length 8 km × thickness 30 m) that were deposited into settings with higher amplitude of relief, like in the Corsican trough, the Kutai basin, and offshore Nigeria. Basin floor topography confining the lobes can be very subtle, and only occur on one side of the system. The two populations of lobe types, however, share similar volumes, in the order of 1 or 2 km3. The largest lobes are observed in the Zaïre fan, where the average lobe volume reaches 3.3 km3 and the smallest lobes are observed in the Corsican trough where the average lobe volume is 0.4 km3. This variation in lobe volume is minor when compared to the variation observed in present-day up-dip drainage systems, which provide sediment to the deep-water depositional systems and their lobes. This suggests that there is a limit to the total volume of sediment that individual lobes can reach before they shift to a new locus of deposition. In otherwords, big systems do not build big lobes, rather more lobes per unit time. Indeed, in the Amazon and the Zaïre systems, lobe life span is estimated to be 600 and 1450 years, respectively, whereas in the Corsican Golo system, lobe life span is ~ 10 times longer, around 10 to 14 × 103 years. A fundamental control on lobe volume is the propensity for flows to find the lowest topography. We postulate that a fundamental control on all distributive systems is the ratio of lobe thickness to feeder channel depth. The surface gradient from the feeder channel base and lobe top will tend to reduce through time as a lobe builds. This is not sustainable, and when a steeper lateral gradient is present a new depositional low will be used for flows to fill.

Down hole transmission system

DOEpatents

Hall, David R [Provo, UT; Hall, Jr., H. Tracy

2007-07-24

A transmission system in a downhole component comprises a data transmission element in both ends of the downhole component. Each data transmission element houses an electrically conducting coil in a MCEI circular trough. The electrically conducting coil comprises at least two generally fractional loops. In the preferred embodiment, the transmission elements are connected by an electrical conductor. Preferably, the electrical conductor is a coaxial cable. Preferably, the MCEI trough comprises ferrite. In the preferred embodiment, the fractional loops are connected by a connecting cable. In one aspect of the present invention, the connecting cable is a pair of twisted wires. In one embodiment the connecting cable is a shielded pair of twisted wires. In another aspect of the present invention, the connecting cable is a coaxial cable. The connecting cable may be disposed outside of the MCEI circular trough.

Contrasting modes of rifting: The Benue Trough and Cameroon Volcanic Line, West Africa

NASA Astrophysics Data System (ADS)

Okereke, C. S.

1988-08-01

The Benue trough of west Africa is commonly believed to be a rift feature that originated in the Cretaceous at about the time that Africa and South America began to separate. Bouguer gravity and available geological data in the trough indicate that its formation was probably the result of regional horizontal stresses in the lithosphere, causing crustal extension and surface subsidence. By contrast, the data for the adjoining Cameroon volcanic line suggests that the associated tensional stresses relate to mantle upwarp causing thinning of the lithosphere and regional crustal uplift similar to that associated with the Kenya rift. Thus the association of passive and active rifts seen in the Afro-Arabia rift system is also a feature of the Cretaceous rift system in west Africa.

Ancient geodynamics and global-scale hydrology on Mars.

PubMed

Phillips, R J; Zuber, M T; Solomon, S C; Golombek, M P; Jakosky, B M; Banerdt, W B; Smith, D E; Williams, R M; Hynek, B M; Aharonson, O; Hauck , S A

2001-03-30

Loading of the lithosphere of Mars by the Tharsis rise explains much of the global shape and long-wavelength gravity field of the planet, including a ring of negative gravity anomalies and a topographic trough around Tharsis, as well as gravity anomaly and topographic highs centered in Arabia Terra and extending northward toward Utopia. The Tharsis-induced trough and antipodal high were largely in place by the end of the Noachian Epoch and exerted control on the location and orientation of valley networks. The release of carbon dioxide and water accompanying the emplacement of approximately 3 x 10(8) cubic kilometers of Tharsis magmas may have sustained a warmer climate than at present, enabling the formation of ancient valley networks and fluvial landscape denudation in and adjacent to the large-scale trough.

Test Tube Tooth: The Next Big Thing.

PubMed

Yadav, Preeti; Tahir, Mohammed; Yadav, Harsh; Sureka, Rakshit; Garg, Aarti

2016-06-01

Unlike some vertebrates and fishes, humans do not have the capacity for tooth regeneration after the loss of permanent teeth. Although artificial replacement with removable dentures, fixed prosthesis and implants is possible through advances in the field of prosthetic dentistry, it would be ideal to recreate a third set of natural teeth to replace lost dentition. For many years now, researchers in the field of tissue engineering have been trying to bioengineer dental tissues as well as whole teeth. In order to attain a whole tooth through dental engineering, that has the same or nearly same biological, mechanical and physical properties of a natural tooth, it's necessary to deal with all the cells and tissues which are concerned with the formation, maintenance and repair of the tooth. In this article we review the steps involved in odontogenesis or organogenesis of a tooth and progress in the bioengineering of a whole tooth.

This meeting: A biased observer's view

NASA Astrophysics Data System (ADS)

Heiles, Carl

1992-06-01

Letting yourself be nominated for a conference summary talk is considered by some to be a big mistake. It eliminates the possibility of making up the sleep lost at night, while partying, during the day, while sitting in the talks. It even forces you to look at all the poster papers. But at a meeting like this, with the wealth of observational data, it is definitely not a mistake: it was even worth missing some of the parties! My problem was to devise a way to be sufficiently selective so as to provide a reasonably coherent summary. I chose to emphasize the multitude of large-scale maps presented at the meeting. Many are relevant to the ``worm paradigm'' (Sec. 2), and the recent γ-ray and ROSAT results are relevant to the Hot Ionized Medium (Sec. 3). And finally, I was impressed by a number of well-crafted smaller-scale observations, which elucidate particular aspects of the interstellar medium (Sec. 4).

This meeting: A biased observer's view

NASA Astrophysics Data System (ADS)

Heiles, Carl

Letting yourself be nominated for a conference summary talk is considered by some to be a big mistake. It eliminates the possibility of making up the sleep lost at night, while partying, during the day, while sitting in the talks. It even forces you to look at all the poster papers. But at a meeting like this, with the wealth of observational data, it is definitely not a mistake: it was even worth missing some of the parties! My problem was to devise a way to be sufficiently selective so as to provide a reasonably coherent summary. I chose to emphasize the multitude of large-scale maps presented at the meeting. Many are relevant to the ``worm paradigm'' (Sec. 2), and the recent γ-ray and ROSAT results are relevant to the Hot Ionized Medium (Sec. 3). And finally, I was impressed by a number of well-crafted smaller-scale observations, which elucidate particular aspects of the interstellar medium (Sec. 4).

Crustal Structure in the Southern Rockall Trough from Satellite Gravity Data: Evidence for Sea-floor Spreading

NASA Astrophysics Data System (ADS)

Chappell, A.; Kusznir, N. J.

2005-05-01

The southern Rockall Trough south of 57 N has previously been interpreted as either an intra-continental rift floored with highly extended continental crust, or a failed oceanic rift formed by Cretaceous sea floor spreading. Satellite gravity, bathymetry data and seismic estimates of sediment thickness are used to derive crustal basement thickness for the southern Rockall Trough and adjacent regions using a gravity inversion method incorporating a correction for the large negative thermal gravity component present in oceanic and stretched continental lithosphere. The marine Bouguer anomaly, derived from satellite free air gravity (Sandwell & Smith 1997) and Gebco 2003 bathymetry data, is inverted using the method of Oldenberg (1974), incorporating an iteratively applied thermal anomaly correction, to give Moho depth. For oceanic crust the thermal anomaly correction is calculated using isochron ages (Muller et al. 1997) and for continental crust from the beta stretching factors resulting from gravity derived crustal basement thickness and an assumed rift age. When sediment thickness and volcanic addition are assumed to be zero, the resulting upper bound of crustal thickness from the gravity inversion is as little as 10 km in the southern Rockall Trough. A segmented axial thickening of the crust at the centre of the Rockall Trough is predicted, between the Barra volcanic ridge and the Anton Dohrn seamount and is interpreted as having a volcanic origin. Inclusion of a sediment thickness correction in the gravity inversion further reduces predicted crustal thickness. A pseudo-sediment-thickness map has been constructed from the available wide-angle data and incorporated in the gravity inversion. The addition of up to 5.5 km of sediment in the gravity inversion reduces the upper bound of crustal thickness to less than 3 km in some locations. The segmented axial thickening and thin crust shown by the gravity inversion, the lack of intra-basinal faulting, and the volcanic origin for the axis shown by normal incidence seismic data, are consistent with a sea-floor spreading origin for the southern Rockall Trough and not formation by intra-continental rifting. We investigate the formation of the southern Rockall Trough using SfMargin, a new model of continental lithosphere thinning leading to continental breakup and sea-floor spreading initiation. Comparisons of the geometry of the southern Rockall Trough predicted by SfMargin with that observed are consistent with a short period (20Ma) of slow Cretaceous sea-floor spreading, followed by thermal subsidence to present day. This work forms part of the NERC Margins iSIMM project. iSIMM investigators are from Liverpool and Cambridge Universities, Badley Geoscience & Schlumberger Cambridge Research supported by the NERC, the DTI, Agip UK, BP, Amerada Hess Ltd, Anadarko, ConocoPhillips, Shell, Statoil and WesternGeco. The iSIMM team comprises NJ Kusznir, RS White, AM Roberts, PAF Christie, A Chappell, J Eccles, R Fletcher, D Healy, N Hurst, ZC Lunnon, CJ Parkin, AW Roberts, LK Smith, V Tymms & R Spitzer.

Western Ross Sea continental slope gravity currents

NASA Astrophysics Data System (ADS)

Gordon, Arnold L.; Orsi, Alejandro H.; Muench, Robin; Huber, Bruce A.; Zambianchi, Enrico; Visbeck, Martin

2009-06-01

Antarctic Bottom Water of the world ocean is derived from dense Shelf Water that is carried downslope by gravity currents at specific sites along the Antarctic margins. Data gathered by the AnSlope and CLIMA programs reveal the presence of energetic gravity currents that are formed over the western continental slope of the Ross Sea when High Salinity Shelf Water exits the shelf through Drygalski Trough. Joides Trough, immediately to the east, offers an additional escape route for less saline Shelf Water, while the Glomar Challenger Trough still farther east is a major pathway for export of the once supercooled low-salinity Ice Shelf Water that forms under the Ross Ice Shelf. The Drygalski Trough gravity currents increase in thickness from ˜100 to ˜400 m on proceeding downslope from ˜600 m (the shelf break) to 1200 m (upper slope) sea floor depth, while turning sharply to the west in response to the Coriolis force during their descent. The mean current pathway trends ˜35° downslope from isobaths. Benthic-layer current and thickness are correlated with the bottom water salinity, which exerts the primary control over the benthic-layer density. A 1-year time series of bottom-water current and hydrographic properties obtained on the slope near the 1000 m isobath indicates episodic pulses of Shelf Water export through Drygalski Trough. These cold (<-1 °C), salty (>34.75) pulses correlate with strong downslope bottom flow. Extreme examples occurred during austral summer/fall 2003, comprising concentrated High Salinity Shelf Water (-1.9 °C; 34.79) and approaching 1.5 m s -1 at descent angles as large as ˜60° relative to the isobaths. Such events were most common during November-May, consistent with a northward shift in position of the dense Shelf Water during austral summer. The coldest, saltiest bottom water was measured from mid-April to mid-May 2003. The summer/fall export of High Salinity Shelf Water observed in 2004 was less than that seen in 2003. This difference, if real, may reflect the influence of the large iceberg C-19 over Drygalski Trough until its departure in mid-May 2003, when there was a marked decrease in the coldest, saltiest gravity current adjacent to Drygalski Trough. Northward transport of cold, saline, recently ventilated Antarctic Bottom Water observed in March 2004 off Cape Adare was ˜1.7 Sv, including ˜0.4 Sv of High Salinity Shelf Water.

Poultry farm hygiene: microbiological quality assessment of drinking water used in layer chickens managed under the battery cage and deep litter systems at three poultry farms in southwestern Nigeria.

PubMed

Folorunso, O R; Kayode, Sule; Onibon, V O

2014-01-01

Water troughs from deep litter and caged chicken water troughs (drinkers) fixed to each of the different 3-tier cages containing layer chickens in Farms A, B and C were subjected to a 7-day study which involved the monitoring of poultry farm hygiene. Drinkers were washed before filling with water on Day 1. For Days 3, 5 and 7 water was served without prior washing. The occurrence and characterization of the bacteria isolates were investigated and data obtained were analyzed and compared. For the bacterial count on Day 1, for layer chickens on cage system, no significant differences (p > 0.05) among the farms and between the farms tier interactions. On Day 3, no significant difference (p > 0.05) among the parameters. On Day 5, there was significant difference (p<0.05) among the farms and on Day 7, there was high significant difference (p < 0.01) among the farms. On Days 5 and 7, there were no significant differences (p>0.05) among the tiers nor between the interactions of the farms and tiers. The bacterial count in water troughs of layer chickens in deep litter system, on Day 1, had no significant differences (p > 0.05) between the farms, water troughs and their interactions. On Day 3, no significant difference (p > 0.05) among the parameters. On Days 5 and 7, there were significant difference (p<0.05) and a high significant difference (p < 0.01) between the farms respectively. On Days 5 and 7, no significant differences between the water troughs and between the interaction of the farms and the water troughs. Farm A isolates contained Staphylococcus aureus, Proteus vulgaris, Streptococcus faecalis, Escherichia coli, Staphylococcus epidermis, Klebsiella sp., Salmonella sp., Bacillus subtilis, Lactobacillus salivarius and Corynebacterium sp. Farm B had Staphylococcus aureus, S. epidermis, Bacillus subtilis, Corynebacterium sp., Escherichia coli, Streptococcus faecalis and Klebsiella sp. while for Farm C, apart from the prevalent bacteria isolates obtained in Farms A and B, additional 2 bacterial isolates, Lactobacillus salivarius and Pseudomonas aeuriginosa were found. In conclusion, water troughs when cleaned on daily basis carry minimum bacterial load. Those left for 3, 5 and 7 days uncleaned had progressively high bacterial loads, suggesting that the flock of birds and the consumers of the eggs and meat from the chickens are at risk of bacterial infection unless strict farm hygiene is ensured through regular monitoring.

Probabilistic Tsunami Hazard Assessment along Nankai Trough (2) a comprehensive assessment including a variety of earthquake source areas other than those that the Earthquake Research Committee, Japanese government (2013) showed

NASA Astrophysics Data System (ADS)

Hirata, K.; Fujiwara, H.; Nakamura, H.; Osada, M.; Morikawa, N.; Kawai, S.; Ohsumi, T.; Aoi, S.; Yamamoto, N.; Matsuyama, H.; Toyama, N.; Kito, T.; Murashima, Y.; Murata, Y.; Inoue, T.; Saito, R.; Takayama, J.; Akiyama, S.; Korenaga, M.; Abe, Y.; Hashimoto, N.

2016-12-01

For the forthcoming Nankai earthquake with M8 to M9 class, the Earthquake Research Committee(ERC)/Headquarters for Earthquake Research Promotion, Japanese government (2013) showed 15 examples of earthquake source areas (ESAs) as possible combinations of 18 sub-regions (6 segments along trough and 3 segments normal to trough) and assessed the occurrence probability within the next 30 years (from Jan. 1, 2013) was 60% to 70%. Hirata et al.(2015, AGU) presented Probabilistic Tsunami Hazard Assessment (PTHA) along Nankai Trough in the case where diversity of the next event's ESA is modeled by only the 15 ESAs. In this study, we newly set 70 ESAs in addition of the previous 15 ESAs so that total of 85 ESAs are considered. By producing tens of faults models, with various slip distribution patterns, for each of 85 ESAs, we obtain 2500 fault models in addition of previous 1400 fault models so that total of 3900 fault models are considered to model the diversity of the next Nankai earthquake rupture (Toyama et al.,2015, JpGU). For PTHA, the occurrence probability of the next Nankai earthquake is distributed to possible 3900 fault models in the viewpoint of similarity to the 15 ESAs' extents (Abe et al.,2015, JpGU). A major concept of the occurrence probability distribution is; (i) earthquakes rupturing on any of 15 ESAs that ERC(2013) showed most likely occur, (ii) earthquakes rupturing on any of ESAs whose along-trench extent is the same as any of 15 ESAs but trough-normal extent differs from it second likely occur, (iii) earthquakes rupturing on any of ESAs whose both of along-trough and trough-normal extents differ from any of 15 ESAs rarely occur. Procedures for tsunami simulation and probabilistic tsunami hazard synthesis are the same as Hirata et al (2015). A tsunami hazard map, synthesized under an assumption that the Nankai earthquakes can be modeled as a renewal process based on BPT distribution with a mean recurrence interval of 88.2 years (ERC, 2013) and an aperiodicity of 0.22, as the median of the values (0.20 to 0.24)that ERC (2013) recommended, suggests that several coastal segments along the southwest coast of Shikoku Island, the southeast coast of Kii Peninsula, and the west coast of Izu Peninsula show over 26 % in exceedance probability that maximum water rise exceeds 10 meters at any coastal point within the next 30 years.

Characterization of inappetent sheep in a feedlot using radio-tracking technology.

PubMed

Barnes, Anne L; Wickham, Sarah L; Admiraal, Ryan; Miller, David W; Collins, Teresa; Stockman, Catherine; Fleming, Patricia A

2018-04-03

The feeding and drinking behaviours of sheep were monitored using RFID technology at a commercial pre-embarkation feedlot in Western Australia with the aim of characterizing feeding and drinking patterns of inappetent sheep that might allow them to be treated. Feeding and drinking behaviours of sheep were compared with their survival and change in body condition. Patterns of number of visits and the time spent at feed and water troughs were analyzed for a total of 8,206 sheep, representing four consignments that were monitored for a range of 6-31 d. Data for feeding and drinking behaviours were compared for the first 6 d. For animals that were alive at exit, 18.9% of sheep attended the feed trough for less than 0.25 h d-1 (15 min per day) on day 1; this decreased to only 2.4% of sheep by day 6. Of the sheep monitored, 0.93% died (n = 76); Salmonella spp. infection was the leading cause of death (n = 40; 52.6% of all deaths) across all months and was accompanied with inanition. There was marked variability in the average time spent at the feed trough for sheep that died eventually from salmonella/inanition (contributing to the lack of statistical difference in time spent at feed trough between sheep dying from different causes; P = 0.056). Over half (55%) of the animals diagnosed with salmonella/inanition spent an average of less than 0.50 h d-1 (30 min per day) and 45% less than 0.25 h d-1 at the feed trough. There was a negative correlation (r) in time spent at the feed trough overtime for individual sheep that died from salmonella/inanition, indicating that these individuals went off their feed. This pattern was not evident for animals that died from other causes (significant difference in r values between five categories of cause of death; P = 0.040). Characterization of feeding behaviour of sheep that died from salmonella/inanition therefore appears to require more than simply monitoring daily intake. There was no difference in time spent at water troughs between sheep that died or were alive at exit (average 0.30 ± 0.23 h d-1). This study reveals that the patterns of feeding and drinking behaviours during pre-embarkation feedlotting do not readily allow identification of animals that warrant singling out for veterinary care or alternative feed arrangements. This result highlights the need for experienced stockmanship in handling these animals.

Lakes in Valles Marineris

NASA Astrophysics Data System (ADS)

Lucchitta, Baerbel K.

2010-10-01

The paper reviews the evolution of hypotheses of lakes in Valles Marineris through observations made from the time of Mariner and continuing through the Viking, MGS, MO, MEx, and MRO missions. Several pertinent findings from these missions are addressed, including: The morphology and composition of the interior layered deposits (ILD); the question whether ILD are deposited inside the troughs or exhumed from the walls; the possible existence of ancestral basins; the derivation of water; arguments for an origin as aqueous, eolian, or pyroclastic sediments, or sub/ice volcanoes; origin of inclined layers, mounds and moats; and age relations of features within and peripheral to the troughs. A possible scenario begins with the collapse of ice-charged ground into ancestral basins along structural planes of weakness due to Tharsis stresses, about 3.5 Ga ago. The basins rapidly filled with water from ground ice, subterranean aquifers, or nearby valley networks. The water spilled out of the peripheral troughs and flowed across high plateaus into early outflow channels. The ancestral basins then filled with sediments derived from valley networks or from trapped eolian or pyroclastic deposits. Alternatively, volcanoes rose under the water or ice to form tuyas. The water was highly acidic, and sediments may have been deposited directly as evaporites or were later altered to evaporites by the brines or by hydrothermal activity. Percolating fluids produced iron oxide concretions. Similar alteration would have affected the putative volcanoes. Most of the ILD were emplaced early in the troughs' history. Shortly thereafter, more water erupted from the peripheral troughs and formed additional chaos and outflow channels. The ancestral basins were breached by erosion and tectonism, and the through-going Coprates/Ius graben system developed. Major lakes within the Valles Marineris dried up and vigorous wind erosion reduced the friable, evaporite-rich sediments to isolated mounds. Simultaneously, the iron oxide concretions weat hered out to form lag deposits mostly at the base of scarps. During that time, some of the ILD may have become tilted by structural deformation. Alternatively, inclined beds on the mounds may have come from draping by volcanic ash or eolian deposits, or by gravity sliding on the steep, evaporite-charged flanks of the mounds. Inclined layers could be readily explained if the ILD were tuyas. Landslides fell into the newly created voids and occasional sliding persisted throughout most of the troughs' history. Minor volcanic activity continued and may have spewed mafic ash onto the eroded ILD-mound surfaces and onto the trough floors. Eventually, only wind persisted, producing yardangs on the ILD and reworking ash, trapped eolian sediments, and debris eroded from the ILD.

High H2O/Ce of K-rich MORB from Lena Trough and Gakkel Ridge, Arctic Ocean

NASA Astrophysics Data System (ADS)

Snow, J. E.; Feig, S. T.

2014-12-01

Lena Trough in the Arctic ocean is the oblique spreading continuation of Gakkel Ridge through the Fram Strait (eg Snow et al. 2011). Extreme trace element and isotopic compositions seen in Lena Trough basalt appear to be the enriched end member dominating the geochemistry of the Western Volcanic Zone of the Western Gakkel Ridge as traced by Pb isotopes, K2O/TiO2, Ba/Nb and other isotopic, major and trace element indicators of mixing (Nauret et al., 2011). This is in contrast to neighboring Gakkel Ridge which has been spreading for 50-60 million years. Basalts from Lena Trough also show a pure MORB noble gas signature (Nauret et al., 2010) and peridotites show no evidence of ancient components in their Os isotopes (Lassiter, et al., in press). The major and trace element compositions of the basalts, however are very distinct from MORB, being far more potassic than all but a single locality on the SW Indian Ridge. We determined H2O and trace element composiitions of a suite of 17 basalt glasses from the Central Lena Trough (CLT) and the Gakkel Western Volcanic Zone, including many of those previously analyzed by Nauret et al. (2012). The Western Gakkel glasses have high H2O/Ce for MORB (>300) suggesting a water rich source consistent with the idea that the northernmost Atlantic mantle is enriched in water (Michael et al., 1995). They are within the range of Eastern Gakkel host glasses determined by Wanless et al, 2013. The Lena Trough (CLT) glasses are very rich in water for MORB (>1% H2O) and are among the highest H2O/Ce (>400) ever measured in MORB aside from melt inclusions in olivine. Mantle melting dynamics and melt evolution cannot account for the H2O/Ce variations in MORB, as these elements have similar behavior during melting and crustal evolution. Interestingly, the H2O/K2O ratios in the basalts are only around 1. This is because the K2O levels in the CLT glasses are very high as well relative to REE. The absolutely linear relationship between H2O and K2O/TiO2 in Lena and Gakkel basalts shows that water systematics in these rocks are completely governed by source composition, with little or no modification by mantle melting dynamics or crystal fractionation. The geochemical influence of the WVZ enriched mantle source declines with distance from Lena Trough along Gakkel Ridge.

Cambrian potential indicated in Kentucky Rome trough

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, D.C.; Drahovzal, J.A.

1996-02-19

This paper reviews recent gas discoveries in the Kentucky Rome trough and the implications for future developments. It reviews the geology and stratigraphy of this structure and identifies the potential zones of production and trapping mechanisms. It provides results from geologic logs and seismic data to provide cross sectional and structural interpretations. Finally it discusses the gas composition of natural gas recovered from the basin.

Concentrating Solar Power Projects - Parabolic Trough Projects |

Science.gov Websites

Project Godawari Solar Project Gujarat Solar One Gulang 100MW Thermal Oil Parabolic Trough project Guzmán Kuraymat (ISCC Kuraymat) Kathu Solar Park KaXu Solar One KVK Energy Solar Project La Africana La Dehesa La Power Facility Nevada Solar One (NSO) NOOR I NOOR II Olivenza 1 Orellana Palma del Río I Palma del Río

Temporal variability of the Circumpolar Deep Water inflow onto the Ross Sea continental shelf

NASA Astrophysics Data System (ADS)

Castagno, Pasquale; Falco, Pierpaolo; Dinniman, Michael S.; Spezie, Giancarlo; Budillon, Giorgio

2017-02-01

The intrusion of Circumpolar Deep Water (CDW) is the primary source of heat, salt and nutrients onto Antarctica's continental shelves and plays a major role in the shelf physical and biological processes. Different studies have analyzed the processes responsible for the transport of CDW across the Ross Sea shelf break, but until now, there are no continuous observations that investigate the timing of the intrusions. Also, few works have focused on the effect of the tides that control these intrusions. In the Ross Sea, the CDW intrudes onto the shelf in several locations, but mostly along the troughs. We use hydrographic observations and a mooring placed on the outer shelf in the middle of the Drygalski Trough in order to characterize the spatial and temporal variability of CDW inflow onto the shelf. Our data span from 2004 to the beginning of 2014. In the Drygalski Trough, the CDW enters as a 150 m thick layer between 250 and 400 m, and moves upward towards the south. At the mooring location, about 50 km from the shelf break, two main CDW cores can be observed: one on the east side of the trough spreading along the west slope of Mawson Bank from about 200 m to the bottom and the other one in the central-west side from 200 m to about 350 m depth. A signature of this lighter and relatively warm water is detected by the instruments on the mooring at bottom of the Drygalski Trough. High frequency periodic CDW intrusion at the bottom of the trough is related to the diurnal and spring/neap tidal cycles. At lower frequency, a seasonal variability of the CDW intrusion is noticed. A strong inflow of CDW is observed every year at the end of December, while the CDW inflow is at its seasonal minimum during the beginning of the austral fall. In addition an interannual variability is also evident. A change of the CDW intrusion before and after 2010 is observed.

Palaeo-ice stream pathways in the easternmost Amundsen Sea Embayment, West Antarctica

NASA Astrophysics Data System (ADS)

Klages, Johann P.; Kuhn, Gerhard; Graham, Alastair G. C.; Smith, James A.; Hillenbrand, Claus-Dieter; Nitsche, Frank O.; Larter, Rob D.; Gohl, Karsten

2015-04-01

Multibeam swath bathymetry datasets collected over the past two decades have been compiled to identify palaeo-ice stream pathways in the easternmost Amundsen Sea Embayment. We mapped 3010 glacial landforms to reconstruct palaeo-ice flow in the ~250 km-long Abbot Glacial Trough that was occupied by a large palaeo-ice stream, fed by two tributaries (Cosgrove and Abbot) that reached the continental shelf edge during the last maximum ice-sheet advance. The mapping has enabled a clear differentiation between glacial landforms interpreted as indicative of wet- (e.g. mega-scale glacial lineations) and cold-based ice (e.g. hill-hole pairs) during the last glaciation of the continental shelf. Both the regions of fast palaeo-ice flow within the palaeo-ice stream troughs, and the regions of slow palaeo-ice flow on adjacent seafloor highs (referred to as inter-ice stream ridges) additionally record glacial landforms such as grounding-zone wedges and recessional moraines that indicate grounding line stillstands of the ice sheet during the last deglaciation from the shelf. As the palaeo-ice stream flowed along a trough with variable geometry and variable subglacial substrate, it appears that trough sections characterized by constrictions and outcropping hard substrate that changes the bed gradient, led the pace of grounding-line retreat to slow and subsequently pause, resulting in the deposition of grounding-zone wedges. The stepped retreat recorded within the Abbot Glacial Trough corresponds well to post-glacial stepped retreat interpreted for the neighbouring Pine Island-Thwaites Palaeo-Ice Stream trough, thus suggesting a uniform pattern of episodic retreat across the eastern Amundsen Sea Embayment. The correlation of episodic retreat features with geological boundaries further emphasises the significance of subglacial geology in steering ice stream flow. Our new geomorphological map of the easternmost Amundsen Sea Embayment resolves the pathways of palaeo-ice streams that were probably all active during the last maximum extent of the ice sheet on this part of the shelf, and reveals the style of postglacial grounding-line retreat. Both are important input variables in ice sheet models and therefore can be used for validating the reliability of these models.

Climatology of atmospheric circulation patterns of Arabian dust in western Iran.

PubMed

Najafi, Mohammad Saeed; Sarraf, B S; Zarrin, A; Rasouli, A A

2017-08-28

Being in vicinity of vast deserts, the west and southwest of Iran are characterized by high levels of dust events, which have adverse consequences on human health, ecosystems, and environment. Using ground based dataset of dust events in western Iran and NCEP/NCAR reanalysis data, the atmospheric circulation patterns of dust events in the Arabian region and west of Iran are identified. The atmospheric circulation patterns which lead to dust events in the Arabian region and western Iran were classified into two main categories: the Shamal dust events that occurs in warm period of year and the frontal dust events as cold period pattern. In frontal dust events, the western trough or blocking pattern at mid-level leads to frontogenesis, instability, and air uplift at lower levels of troposphere in the southwest of Asia. Non-frontal is other pattern of dust event in the cold period and dust generation are due to the regional circulation systems at the lower level of troposphere. In Shamal wind pattern, the Saudi Arabian anticyclone, Turkmenistan anticyclone, and Zagros thermal low play the key roles in formation of this pattern. Summer and transitional patterns are two sub-categories of summer Shamal wind pattern. In summer trough pattern, the mid-tropospheric trough leads to intensify the surface thermal systems in the Middle East and causes instability and rising of wind speed in the region. In synthetic pattern of Shamal wind and summer trough, dust is created by the impact of a trough in mid-levels of troposphere as well as existing the mentioned regional systems which are contributed in formation of summer Shamal wind pattern.

Morphology and sedimentology of glacigenic submarine fans on the west Greenland continental margin

NASA Astrophysics Data System (ADS)

O'Cofaigh, Colm; Hogan, Kelly A.; Dowdeswell, Julian A.; Jennings, Anne E.; Noormets, Riko; Evans, Jeffrey

2014-05-01

Along the West Greenland continental margin adjoining Baffin Bay, bathymetric data show a series of large submarine fans located at the mouths of cross-shelf troughs. Two of these fans, the Uummannaq Fan and the Disko Fan are trough-mouth fans built largely of debris delivered from ice sheet outlets of the Greenland Ice Sheet during past glacial maxima. On the Uummannaq Fan glacigenic debris flow deposits occur on the upper slope and extend to at least 1800 m water depth in front of the trough-mouth. The debris flow deposits are related to the remobilisation of subglacial debris that was delivered onto the upper slope at times when an ice stream was positioned at the shelf edge. In contrast, sedimentary facies from the northern sector of the fan are characterised by hemipelagic and ice-rafted sediments and turbidites; glacigenic debris flows are notably absent in cores from this region. Further south along the Greenland continental margin the surface of the Disko Fan is prominently channelised and associated sediments are acoustically stratified. Although glacigenic debris flow deposits do occur on the upper Disko Fan, sediments recovered in cores from elsewhere on the fan record the influence of turbidity current and meltwater sedimentation. The channelised form of the Disko fan contrasts markedly with that of the Uummannaq Fan and, more widely, with trough mouth fans from the Polar North Atlantic. Collectively these data highlight the variability of glacimarine depositional processes operating on trough-mouth fans on high-latitude continental slopes and show that glacigenic debris flows are but one of a number of mechanisms by which such large glacially-influenced depocentres form.

Earth Observations

NASA Image and Video Library

2013-06-21

ISS036-E-011034 (21 June 2013) --- The Salton Trough is featured in this image photographed by an Expedition 36 crew member on the International Space Station. The Imperial and Coachella Valleys of southern California – and the corresponding Mexicali Valley and Colorado River Delta in Mexico – are part of the Salton Trough, a large geologic structure known to geologists as a graben or rift valley that extends into the Gulf of California. The trough is a geologically complex zone formed by interaction of the San Andreas transform fault system that is, broadly speaking, moving southern California towards Alaska; and the northward motion of the Gulf of California segment of the East Pacific Rise that continues to widen the Gulf of California by sea-floor spreading. According to scientists, sediments deposited by the Colorado River have been filling the northern rift valley (the Salton Trough) for the past several million years, excluding the waters of the Gulf of California and providing a fertile environment – together with irrigation—for the development of extensive agriculture in the region (visible as green and yellow-brown fields at center). The Salton Sea, a favorite landmark of astronauts in low Earth orbit, was formed by an irrigation canal rupture in 1905, and today is sustained by agricultural runoff water. A wide array of varying landforms and land uses in the Salton Trough are visible from space. In addition to the agricultural fields and Salton Sea, easily visible metropolitan areas include Yuma, AZ (lower left); Mexicali, Baja California, Mexico (center); and the San Diego-Tijuana conurbation on the Pacific Coast (right). The approximately 72-kilometer-long Algodones Dunefield is visible at lower left.

Relationship Between FEV1 and Patient-Reported Outcomes Changes: Results of a Meta-Analysis of Randomized Trials in Stable COPD.

PubMed

de la Loge, Christine; Tugaut, Béatrice; Fofana, Fatoumata; Lambert, Jérémy; Hennig, Michael; Tschiesner, Uta; Vahdati-Bolouri, Mitra; Segun Ismaila, Afisi; Suresh Punekar, Yogesh

2016-03-15

Background: This meta-analysis assessed the relationship between change from baseline (CFB) in spirometric measurements (trough forced expiratory volume in 1 second [FEV 1 ] and FEV 1 area under the curve [AUC]) and patient-reported outcomes (St. George's Respiratory Questionnaire total score [SGRQ] CFB, Transition Dyspnea Index [TDI] and exacerbation rates) after 6-12 months' follow-up, using study treatment-group level data. Methods: A systematic literature search was performed for randomized controlled trials of ≥24 weeks duration in adults with chronic obstructive pulmonary disease (COPD). Studies reporting ≥1 spirometric measurement and ≥1 patient-reported outcome (PRO) at baseline and at study endpoint were selected. The relationships between PROs and spirometric endpoints were assessed using Pearson correlation coefficient and meta-regression. Results: Fifty-two studies (62,385 patients) were included. Primary weighted analysis conducted at the last assessment showed a large significant negative correlation (r, -0.68 [95% confidence interval (CI); -0.77, -0.57]) between trough FEV 1 and SGRQ. Improvement of 100 mL in trough FEV 1 corresponded to a 5.9 point reduction in SGRQ. Similarly, a reduction of 4 points on SGRQ corresponded to 40 mL improvement in trough FEV 1 ( p <0.001). The weighted correlation coefficients of trough FEV 1 with TDI, exacerbation rate (all) and exacerbation rate (moderate/severe) at last assessment point were 0.57, -0.69 and -0.57, respectively (all p <0.05). For the analyses excluding placebo groups, the correlations of FEV 1 with SGRQ and TDI were lower but significant. Conclusions: A strong association exists between changes in spirometric measurements and changes in PROs.

How older people in the United States and Germany fared in the growth years of the 1980s: a cross-sectional versus a longitudinal view.

PubMed

Burkhauser, R V; Cutts, A C; Lillard, D R

1999-09-01

The goal of the study was to show that cross-sectional and longitudinal data yield dramatically different answers to a basic question: "How did older persons fare in the recovery years of the 1980s?" The United States Panel Study of Income Dynamics and the German Socio-Economic Panel are used cross-sectionally to capture changes in the economic well-being of older persons in the trough and peak years of the 1980s business cycle, and longitudinally to trace how the economic well-being of a given cohort of older persons changed over those years. Kernel density estimation is then used to show how the distribution of economic well-being of these populations changed over these years. Cross-sectional comparisons confirm that persons aged 65 and over in the peak year were better off than persons aged 65 and over in the trough year in both countries. Longitudinal comparisons, however, show that persons aged 65 and over in the trough year who survived to the peak year received a substantially smaller share of the rewards of economic recovery than cross-sectional comparisons imply. Moreover, the entire income distribution of older persons in the United States shifted downwards. Compositional changes in the cross-sectional data, caused by the entry of high-income persons who are young in the peak year but old in the trough year, obscure the decline in the economic well-being of the cohort of older persons who survived the trough year, in cross-sectional comparisons of older populations in the United States in the 1980s.

On Local Ionization Equilibrium and Disk Winds in QSOs

NASA Astrophysics Data System (ADS)

Pereyra, Nicolas A.

2014-11-01

We present theoretical C IV λλ1548,1550 absorption line profiles for QSOs calculated assuming the accretion disk wind (ADW) scenario. The results suggest that the multiple absorption troughs seen in many QSOs may be due to the discontinuities in the ion balance of the wind (caused by X-rays), rather than discontinuities in the density/velocity structure. The profiles are calculated from a 2.5-dimensional time-dependent hydrodynamic simulation of a line-driven disk wind for a typical QSO black hole mass, a typical QSO luminosity, and for a standard Shakura-Sunyaev disk. We include the effects of ionizing X-rays originating from within the inner disk radius by assuming that the wind is shielded from the X-rays from a certain viewing angle up to 90° ("edge on"). In the shielded region, we assume constant ionization equilibrium, and thus constant line-force parameters. In the non-shielded region, we assume that both the line-force and the C IV populations are nonexistent. The model can account for P-Cygni absorption troughs (produced at edge on viewing angles), multiple absorption troughs (produced at viewing angles close to the angle that separates the shielded region and the non-shielded region), and for detached absorption troughs (produced at an angle in between the first two absorption line types); that is, the model can account for the general types of broad absorption lines seen in QSOs as a viewing angle effect. The steady nature of ADWs, in turn, may account for the steady nature of the absorption structure observed in multiple-trough broad absorption line QSOs. The model parameters are M bh = 109 M ⊙ and L disk = 1047 erg s-1.

Nationwide conversion to generic tacrolimus in pediatric kidney transplant recipients.

PubMed

Naicker, Derisha; Reed, Peter W; Ronaldson, Jane; Kara, Tonya; Wong, William; Prestidge, Chanel

2017-11-01

Bioequivalence between Tacrolimus Prograf® and generic tacrolimus formulations has been demonstrated in adult populations, however clinical experience and safety data regarding generic tacrolimus in pediatric transplant recipients is limited. This study aimed to evaluate conversion from Tacrolimus Prograf® to Sandoz® in pediatric renal transplant recipients nationwide. The primary outcome was a change in mean trough tacrolimus concentration. Additionally, changes in tacrolimus intra-patient coefficient of variation (CoV), allograft function, requirement for dose adjustments, and episodes of biopsy-proven rejection were evaluated. Retrospective cohort study in 37 pediatric renal transplant recipients who switched to Tacrolimus Sandoz®. Each patient had three pre-conversion tacrolimus trough and creatinine concentrations within the 4 months prior and three post-conversion concentrations on day 3, 10, and the next subsequent level. Mean pre- and post-conversion tacrolimus trough concentrations and glomerular filtration rate (eGFR) were calculated. Tacrolimus concentration, CoV, and creatinine differences were compared by paired t test. Thirty-seven patients (41% females, age 3-18 years) were included. Average intra-patient difference in trough tacrolimus concentration was 0.05μg/l (95% CI -0.37 to 0.47). Average intra-patient difference in eGFR was -1.20 ml/min/1.73 2 (95% CI -3.53 to 1.13). Three patients had acute rejection during 12 months post-conversion compared to none during 12 months pre-conversion. Pediatric renal transplant recipients can be converted from Tacrolimus Prograf® to Sandoz® with negligible change in trough concentration, dose adjustments, or immediate allograft function. Of concern was the number of acute rejection episodes, however non-adherence contributed to at least one episode and this difference was determined clinically and statistically not significant.

Constraints on mantle melt geometries from body wave attenuation in the Salton Trough and Snake River Plain

NASA Astrophysics Data System (ADS)

Byrnes, J. S.; Bezada, M.

2017-12-01

Melt can be retained in the mantle at triple junctions between grain boundaries, be spread in thin films along two-grain boundaries, or be organized by shear into elongate melt-rich bands. Which of these geometries is most prevalent is unknown. This ambiguity makes the interpretation of anomalous seismic velocities and quality factors difficult, since different geometries would result in different mechanical effects. Here, we compare observations of seismic attenuation beneath the Salton Trough and the Snake River Plain; two regions where the presence of melt has been inferred. The results suggest that seismic attenuation is diagnostic of melt geometry. We measure the relative attenuation of P waves from deep focus earthquakes using a time-domain method. Even though the two regions are underlain by comparably strong low-velocity anomalies, their attenuation signature is very different. The upper mantle beneath the Salton Trough is sufficiently attenuating that the presence of melt must lower Qp, while attenuation beneath the Snake River Plain is not anomalous with respect to surrounding regions. These seemingly contradictory results can be reconciled if different melt geometries characterize each region. SKS splitting from the Salton Trough suggests that melt is organized into melt-rich bands, while this is not the case for the Snake River Plain. We infer that beneath the Snake River Plain melt is retained at triple junctions between grain boundaries, a geometry that is not predicted to cause seismic attenuation. More elongate geometries beneath the Salton Trough may cause seismic attenuation via the melt-squirt mechanism. In light of these results, we conclude that prior observations of low seismic velocities with somewhat high quality factors beneath the East Pacific Rise and Southern California suggest that melt does not organize into elongate bands across much of the asthenosphere.

Relationship Between FEV1 and Patient-Reported Outcomes Changes: Results of a Meta-Analysis of Randomized Trials in Stable COPD

PubMed Central

de la Loge, Christine; Tugaut, Béatrice; Fofana, Fatoumata; Lambert, Jérémy; Hennig, Michael; Tschiesner, Uta; Vahdati-Bolouri, Mitra; Segun Ismaila, Afisi; Suresh Punekar, Yogesh

2016-01-01

Background: This meta-analysis assessed the relationship between change from baseline (CFB) in spirometric measurements (trough forced expiratory volume in 1 second [FEV1] and FEV1 area under the curve [AUC]) and patient-reported outcomes (St. George’s Respiratory Questionnaire total score [SGRQ] CFB, Transition Dyspnea Index [TDI] and exacerbation rates) after 6-12 months’ follow-up, using study treatment-group level data. Methods: A systematic literature search was performed for randomized controlled trials of ≥24 weeks duration in adults with chronic obstructive pulmonary disease (COPD). Studies reporting ≥1 spirometric measurement and ≥1 patient-reported outcome (PRO) at baseline and at study endpoint were selected. The relationships between PROs and spirometric endpoints were assessed using Pearson correlation coefficient and meta-regression. Results: Fifty-two studies (62,385 patients) were included. Primary weighted analysis conducted at the last assessment showed a large significant negative correlation (r, −0.68 [95% confidence interval (CI); −0.77, −0.57]) between trough FEV1 and SGRQ. Improvement of 100 mL in trough FEV1 corresponded to a 5.9 point reduction in SGRQ. Similarly, a reduction of 4 points on SGRQ corresponded to 40 mL improvement in trough FEV1 (p<0.001). The weighted correlation coefficients of trough FEV1 with TDI, exacerbation rate (all) and exacerbation rate (moderate/severe) at last assessment point were 0.57, -0.69 and -0.57, respectively (all p<0.05). For the analyses excluding placebo groups, the correlations of FEV1 with SGRQ and TDI were lower but significant. Conclusions: A strong association exists between changes in spirometric measurements and changes in PROs. PMID:28848877

The nature of the crust under Cayman Trough from gravity

USGS Publications Warehouse

ten Brink, Uri S.; Coleman, D.F.; Dillon, William P.

2002-01-01

Considerable crustal thickness variations are inferred along Cayman Trough, a slow-spreading ocean basin in the Caribbean Sea, from modeling of the gravity field. The crust to a distance of 50 km from the spreading center is only 2–3 km thick in agreement with dredge and dive results. Crustal thickness increases to ∼5.5 km at distances between 100 and 430 km west of the spreading center and to 3.5–6 km at distances between 60 and 370 km east of the spreading center. The increase in thickness is interpreted to represent serpentinization of the uppermost mantle lithosphere, rather than a true increase in the volume of accreted ocean crust. Serpentinized peridotite rocks have indeed been dredged from the base of escarpments of oceanic crust rocks in Cayman Trough. Laboratory-measured density and P-wave speed of peridotite with 40–50% serpentine are similar to the observed speed in published refraction results and to the inferred density from the model. Crustal thickness gradually increases to 7–8 km at the far ends of the trough partially in areas where sea floor magnetic anomalies were identified. Basement depth becomes gradually shallower starting 250 km west of the rise and 340 km east of the rise, in contrast to the predicted trend of increasing depth to basement from cooling models of the oceanic lithosphere. The gradual increase in apparent crustal thickness and the shallowing trend of basement depth are interpreted to indicate that the deep distal parts of Cayman Trough are underlain by highly attenuated crust, not by a continuously accreted oceanic crust.

Effect of azilsartan versus candesartan on morning blood pressure surges in Japanese patients with essential hypertension

PubMed Central

Kario, Kazuomi; Enya, Kazuaki; Sugiura, Kenkichi; Ikeda, Yoshinori

2014-01-01

Morning blood pressure (BP) surge is reported as a risk factor for cardiovascular events and end-organ damage independent of the 24-h BP level. Controlling morning BP surge is therefore important to help prevent onset of cardiovascular disease. We compared the efficacy of azilsartan and candesartan in controlling morning systolic BP (SBP) surges by analyzing relevant ambulatory BP monitoring data in patients with/without baseline BP surges. As part of a 16-week randomized, double-blind study of azilsartan (20–40 mg once daily) and candesartan (8–12 mg once daily) in Japanese patients with essential hypertension, an exploratory analysis was carried out using ambulatory BP monitoring at baseline and week 14. The effects of study drugs on morning BP surges, including sleep trough surge (early morning SBP minus the lowest night-time SBP) and prewaking surge (early morning SBP minus SBP before awakening), were evaluated. Patients with sleep trough surge of at least 35 mmHg were defined by the presence of a morning BP surge (the ‘surge group’). Sleep trough surge and prewaking surge data were available at both baseline and week 14 in 548 patients, 147 of whom (azilsartan 76; candesartan 71) had a baseline morning BP surge. In surge group patients, azilsartan significantly reduced both the sleep trough surge and the prewaking surge at week 14 compared with candesartan (least squares means of the between-group differences −5.8 mmHg, P=0.0395; and −5.7 mmHg, P=0.0228, respectively). Once-daily azilsartan improved sleep trough surge and prewaking surge to a greater extent than candesartan in Japanese patients with grade I–II essential hypertension. PMID:24710336

Effect of azilsartan versus candesartan on morning blood pressure surges in Japanese patients with essential hypertension.

PubMed

Rakugi, Hiromi; Kario, Kazuomi; Enya, Kazuaki; Sugiura, Kenkichi; Ikeda, Yoshinori

2014-06-01

Morning blood pressure (BP) surge is reported as a risk factor for cardiovascular events and end-organ damage independent of the 24-h BP level. Controlling morning BP surge is therefore important to help prevent onset of cardiovascular disease. We compared the efficacy of azilsartan and candesartan in controlling morning systolic BP (SBP) surges by analyzing relevant ambulatory BP monitoring data in patients with/without baseline BP surges. As part of a 16-week randomized, double-blind study of azilsartan (20-40 mg once daily) and candesartan (8-12 mg once daily) in Japanese patients with essential hypertension, an exploratory analysis was carried out using ambulatory BP monitoring at baseline and week 14. The effects of study drugs on morning BP surges, including sleep trough surge (early morning SBP minus the lowest night-time SBP) and prewaking surge (early morning SBP minus SBP before awakening), were evaluated. Patients with sleep trough surge of at least 35 mmHg were defined by the presence of a morning BP surge (the 'surge group'). Sleep trough surge and prewaking surge data were available at both baseline and week 14 in 548 patients, 147 of whom (azilsartan 76; candesartan 71) had a baseline morning BP surge. In surge group patients, azilsartan significantly reduced both the sleep trough surge and the prewaking surge at week 14 compared with candesartan (least squares means of the between-group differences -5.8 mmHg, P=0.0395; and -5.7 mmHg, P=0.0228, respectively). Once-daily azilsartan improved sleep trough surge and prewaking surge to a greater extent than candesartan in Japanese patients with grade I-II essential hypertension.

Evaluation of risk factors for vancomycin-induced nephrotoxicity.

PubMed

Park, So Jin; Lim, Na Ri; Park, Hyo Jung; Yang, Jae Wook; Kim, Min-Ji; Kim, Kyunga; In, Yong Won; Lee, Young Mee

2018-05-09

Background Vancomycin is a glycopeptide antibiotic of choice for the treatment of serious infections caused by multi-resistant Gram-positive bacteria. However, vancomycin-associated nephrotoxicity (VAN) often limits its use. Previous data suggested a few risk factors of VAN, including higher mean vancomycin trough level, higher daily doses, old age, long duration of vancomycin therapy, and concomitant nephrotoxins. Objective To evaluate the incidence and risk factors of VAN and determine whether higher vancomycin trough concentrations were associated with a greater risk for VAN. Settings A retrospective, observational, single-center study at the 1960-bed university-affiliated tertiary care hospital (Samsung Medical Center), Seoul, Korea. Method A retrospective analysis of adult patients who received vancomycin parenterally in a tertiary care medical center from March 1, 2013 to June 30, 2013 was performed. We excluded patients with a baseline serum creatinine level > 2 mg/dL and those who had a history of end-stage renal disease and dialysis at baseline. The clinical characteristics were compared between patients with nephrotoxicity and those without nephrotoxicity to identify the risk factors associated with VAN. Main outcome measure Incidence of VAN and VAN-associated risk factors were analyzed. Results Of the 315 vancomycin-treated patients, nephrotoxicity occurred in 15.2% of the patients. In multivariate analysis, higher vancomycin trough concentrations of > 20 mg∕L (OR 9.57, 95% CI 2.49-36.83, p < 0.01) and intensive care unit (ICU) residence (OR 2.86, 95% CI 1.41-5.82, p < 0.01) were independently associated with VAN. Conclusion Our findings suggest that higher vancomycin trough levels and ICU residence might be associated with a greater risk for VAN. More careful monitoring of vancomycin serum trough levels and patient status might facilitate the timely prevention of VAN.

Heat Loss Testing of Schott's 2008 PTR70 Parabolic Trough Receiver

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burkholder, Frank; Kutscher, Chuck

2009-05-01

Two Schott 2008 model year PTR70 HCEs were tested on NREL's heat loss test stand from 100 - 500 deg C in 50 deg C increments. Absorber emittance was determined from the laboratory testing so that the performance of the HCEs could be modeled in a parabolic trough collector. Collector/HCE simulation results for many different field operation conditions were used to create heat loss correlationcoefficients for Excelergy and SAM. SAM estimates that the decreased emittance of the 2008 PTR70 will decrease the LCOE for parabolic trough power plants by 0.5 cents/kWh and increase the electricity generated by 5% relative tomore » previous PTR70s. These conclusions assume that the 2008 PTR70 is supplied at the same cost and with the same optical performance as earlier PTR70 models.« less

Post-early cretaceous landform evolution along the western margin of the banca~nnia trough, western nsw

USGS Publications Warehouse

Gibson, D.L.

2000-01-01

Previously undated post-Devonian sediments outcropping north of Fowlers Gap station near the western margin of the Bancannia Trough are shown by plant macro- and microfossil determinations to be of Early Cretaceous (most likely Neocomian and/or Aptian) age, and thus part of the Eromanga Basin. They are assigned to the previously defined Telephone Creek Formation. Study of the structural configuration of this unit and the unconformably underlying Devonian rocks suggests that the gross landscape architecture of the area results from post-Early Cretaceous monoclinal folding along blind faults at the western margin of the trough, combined with the effects of differential erosion. This study shows that, while landscape evolution in the area has been dynamic, the major changes that have occurred are on a geological rather than human timescale.

Element of an inductive coupler

DOEpatents

Hall, David R.; Fox, Joe

2006-08-15

An element for an inductive coupler in a downhole component comprises magnetically conductive material, which is disposed in a recess in annular housing. The magnetically conductive material forms a generally circular trough. The circular trough comprises an outer generally U-shaped surface, an inner generally U-shaped surface, and two generally planar surfaces joining the inner and outer surfaces. The element further comprises pressure relief grooves in at least one of the surfaces of the circular trough. The pressure relief grooves may be scored lines. Preferably the pressure relief grooves are parallel to the magnetic field generated by the magnetically conductive material. The magnetically conductive material is selected from the group consisting of soft iron, ferrite, a nickel iron alloy, a silicon iron alloy, a cobalt iron alloy, and a mu-metal. Preferably, the annular housing is a metal ring.

Improvement Design of Parabolic Trough

NASA Astrophysics Data System (ADS)

Ihsan, S. I.; Safian, M. A. I. M.; Taufek, M. A. M.; Mohiuddin, A. K. M.

2017-03-01

The performance of parabolic trough solar collector (PTSC) has been evaluated using different heat transfer working fluids; namely water and SAE20 W50 engine oil. New and slightly improved PTSC was developed to run the experimental study. Under the meteorological conditions of Malaysia, authors found that PTSC can operate at a higher temperature than water collector but the performance efficiency of collector using engine oil is much lower than the water collector.

Modulations of Driven Nonlinear Surface Waves on Water and Liquid Helium-4.

DTIC Science & Technology

1985-06-01

loop to control drive amplitude. 63 CHAPTER III. DATA AND INTERPRETATION. Section 5. Cockscombs. 25. Cockscomb in water at f/30. 67 26. Double...annular trough, sealed and then partially filled with normal or superfluid helium, is oscillated vertically and supported 6 . . ... . . . . . 41 700...44 0 .0 0 00 loudspeaker surface wave sealed trough transducer shel oo •Figure 3. Schmatic of the helium experiment. 8 r

Current status of the western gray squirrel population in the Puget Trough, Washington.

Treesearch

R. Bayrakci; A.B. Carey; T.M. Wilson

2001-01-01

The Puget Trough population of Washington’s state-threatened western gray squirrel is centered in Oregon white oak ecotones adjacent to conifer forests and prairies on the Fort Lewis Military Reservation. Our goal was to determine the current status of western gray squirrels in this region. In 1998, we found five western gray squirrels in 538 hours of foot surveys in...

Heavy precipitation episodes in the Western Mediterranean : Use of a semi-Lagrangian advection model for the fine-scale description of upper-level troughs

NASA Astrophysics Data System (ADS)

Gauthier, N.; Claud, C.; Funatsu, B. M.; Chaboureau, J.-P.; Argence, S.; Lambert, D.; Richard, E.; Hauchecorne, A.; Arbogast, P.; Maynard, K.

2009-09-01

Heavy precipitation events over the Mediterranean Sea are generally associated with upper-level troughs. The mesoscale structures of such troughs are however not well reproduced by the atmospheric analyses due to inappropriate spatial resolution. We propose here to use a semi-Lagrangian advection model called MIMOSA (Modélisation Isentrope du transport Méso-échelle de l'Ozone Stratosphérique par Advection) initially developed to describe stratospheric filaments, to calculate fine-scale Potential Vorticity (PV) fields on isentropic surfaces near the tropopause. After a description of MIMOSA, we will focus on the model-generated PV fields for several high impact weather cases that occurred over the Western Mediterreanean Sea. We will demonstrate the ability of MIMOSA to resolve fine scale structures of upper-level troughs considering the Algiers' flash flood, which occurred on November 2001, and then a heavy precipitation event over southeast France on the 5-6 September 2005. Finally, with a PV inversion method, we will show the impact of the fine scales PV structures as depicted by MIMOSA to improve the numerical simulation of a « hurricane » that hit Italy in September 2006, both in terms of surface pressure and precipitation forecasts.

Microbial Community in the Hydrothermal System at Southern Mariana Trough

NASA Astrophysics Data System (ADS)

Kato, S.; Itahashi, S.; Kakegawa, T.; Utsumi, M.; Maruyama, A.; Ishibashi, J.; Marumo, K.; Urabe, T.; Yamagishi, A.

2004-12-01

There is unique ecosystem around deep-sea hydrothermal area. Living organisms are supported by chemical free energy provided by the hydrothermal water. The ecosystem is expected to be similar to those in early stage of life history on the earth, when photosynthetic organisms have not emerged. In this study, we have analyzed the microbial diversity in the hydrothermal area at southern Mariana trough. In the "Archaean Park Project" supported by special Coordination Fund, four holes were bored and cased by titanium pipes near hydrothermal vents in the southern Mariana trough in 2004. Hydrothermal fluids were collected from these cased holes and natural vents in this area. Microbial cells were collected by filtering the hydrothermal fluid in situ or in the mother sip. Filters were stored at -80C and used for DNA extraction. Chimneys at this area was also collected and stored at -80C. The filters and chimney samples were crushed and DNA was extracted. DNA samples were used for amplification of 16S rDNA fragments by PCR using archaea specific primers and universal primers. The PCR fragments were cloned and sequenced. These PCR clones of different samples will be compared. We will extend our knowledge about microbiological diversity at Southern Mariana trough to compare the results obtained at other area.

Full parabolic trough qualification from prototype to demonstration loop

NASA Astrophysics Data System (ADS)

Janotte, Nicole; Lüpfert, Eckhard; Pottler, Klaus; Schmitz, Mark

2017-06-01

On the example of the HelioTrough® collector development the full accompanying and supporting qualification program for large-scale parabolic trough collectors for solar thermal power plants is described from prototype to demonstration loop scale. In the evaluation process the actual state and the optimization potential are assessed. This includes the optical and geometrical performance determined by concentrator shape, deformation, assembly quality and local intercept factor values. Furthermore, its mechanical performance in terms of tracking accuracy and torsional stiffness and its thermal system performance on the basis of the overall thermal output and heat loss are evaluated. Demonstration loop tests deliver results of collector modules statistical slope deviation of 1.9 to 2.6 mrad, intercept factor above 98%, peak optical performance of 81.6% and heat loss coefficients from field tests. The benefit of such a closely monitored development lies in prompt feedback on strengths, weaknesses and potential improvements on the new product at any development stage from first module tests until demonstration loop evaluation. The product developer takes advantage of the achieved technical maturity, already before the implementation in a commercial power plant. The well-understood performance characteristics allow the reduction of safety margins making the new HelioTrough collector competitive from the start.

Inductive coupler for downhole components and method for making same

DOEpatents

Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Dahlgren, Scott; Briscoe, Michael A.; Sneddon, Cameron; Fox, Joe

2006-05-09

The present invention includes a method of making an inductive coupler for downhole components. The method includes providing an annular housing, preferably made of steel, the housing having a recess. A conductor, preferably an insulated wire, is also provided along with a plurality of generally U-shaped magnetically conducting, electrically insulating (MCEI) segments. Preferably, the MCEI segments comprise ferrite. An assembly is formed by placing the plurality of MCEI segments within the recess in the annular housing. The segments are aligned to form a generally circular trough. A first portion of the conductor is placed within the circular trough. This assembly is consolidated with a meltable polymer which fills spaces between the segments, annular housing and the first portion of the conductor. The invention also includes an inductive coupler including an annular housing having a recess defined by a bottom portion and two opposing side wall portions. At least one side wall portion includes a lip extending toward but not reaching the other side wall portion. A plurality of generally U-shaped MCEI segments, preferably comprised of ferrite, are disposed in the recess and aligned so as to form a circular trough. The coupler further includes a conductor disposed within the circular trough and a polymer filling spaces between the segments, the annular housing and the conductor.

Hydraulic Characteristics of Bedrock Constrictions and Evaluation of One- and Two-Dimensional Models of Flood Flow on the Big Lost River at the Idaho National Engineering and Environmental Laboratory, Idaho

USGS Publications Warehouse

Berenbrock, Charles; Rousseau, Joseph P.; Twining, Brian V.

2007-01-01

A 1.9-mile reach of the Big Lost River, between the Idaho National Engineering and Environmental Laboratory (INEEL) diversion dam and the Pioneer diversion structures, was investigated to evaluate the effects of streambed erosion and bedrock constrictions on model predictions of water-surface elevations. Two one-dimensional (1-D) models, a fixed-bed surface-water flow model (HEC-RAS) and a movable-bed surface-water flow and sediment-transport model (HEC-6), were used to evaluate these effects. The results of these models were compared to the results of a two-dimensional (2-D) fixed-bed model [Transient Inundation 2-Dimensional (TRIM2D)] that had previously been used to predict water-surface elevations for peak flows with sufficient stage and stream power to erode floodplain terrain features (Holocene inset terraces referred to as BLR#6 and BLR#8) dated at 300 to 500 years old, and an unmodified Pleistocene surface (referred to as the saddle area) dated at 10,000 years old; and to extend the period of record at the Big Lost River streamflow-gaging station near Arco for flood-frequency analyses. The extended record was used to estimate the magnitude of the 100-year flood and the magnitude of floods with return periods as long as 10,000 years. In most cases, the fixed-bed TRIM2D model simulated higher water-surface elevations, shallower flow depths, higher flow velocities, and higher stream powers than the fixed-bed HEC-RAS and movable-bed HEC-6 models for the same peak flows. The HEC-RAS model required flow increases of 83 percent [100 to 183 cubic meters per second (m3/s)], and 45 percent (100 to 145 m3/s) to match TRIM2D simulations of water-surface elevations at two paleoindicator sites that were used to determine peak flows (100 m3/s) with an estimated return period of 300 to 500 years; and an increase of 13 percent (150 to 169 m3/s) to match TRIM2D water-surface elevations at the saddle area that was used to establish the peak flow (150 m3/s) of a paleoflood with a return period of 10,000 years. A field survey of the saddle area, however, indicated that the elevation of the lowest point on the saddle area was 1.2 feet higher than indicated on the 2-ft contour map that was used in the TRIM2D model. Because of this elevation discrepancy, HEC-RAS model simulations indicated that a peak flow of at least 210 m3/s would be needed to initiate flow across the 10,000-year old Pleistocene surface. HEC-6 modeling results indicated that to compensate for the effects of streambed scour, additional flow increases would be needed to match HEC-RAS and TRIM2D water-surface elevations along the upper and middle reaches of the river, and to compensate for sediment deposition, a slight decrease in flows would be needed to match HEC-RAS water-surface elevations along the lower reach of the river. Differences in simulated water-surface elevations between the TRIM2D and the HEC-RAS and HEC-6 models are attributed primarily to differences in topographic relief and to differences in the channel and floodplain geometries used in these models. Topographic differences were sufficiently large that it was not possible to isolate the effects of these differences on simulated water-surface elevations from those attributable to the effects of supercritical flow, streambed scour, and sediment deposition.

Steady-state and transient models of groundwater flow and advective transport, Eastern Snake River Plain aquifer, Idaho National Laboratory and vicinity, Idaho

USGS Publications Warehouse

Ackerman, Daniel J.; Rousseau, Joseph P.; Rattray, Gordon W.; Fisher, Jason C.

2010-01-01

Three-dimensional steady-state and transient models of groundwater flow and advective transport in the eastern Snake River Plain aquifer were developed by the U.S. Geological Survey in cooperation with the U.S. Department of Energy. The steady-state and transient flow models cover an area of 1,940 square miles that includes most of the 890 square miles of the Idaho National Laboratory (INL). A 50-year history of waste disposal at the INL has resulted in measurable concentrations of waste contaminants in the eastern Snake River Plain aquifer. Model results can be used in numerical simulations to evaluate the movement of contaminants in the aquifer. Saturated flow in the eastern Snake River Plain aquifer was simulated using the MODFLOW-2000 groundwater flow model. Steady-state flow was simulated to represent conditions in 1980 with average streamflow infiltration from 1966-80 for the Big Lost River, the major variable inflow to the system. The transient flow model simulates groundwater flow between 1980 and 1995, a period that included a 5-year wet cycle (1982-86) followed by an 8-year dry cycle (1987-94). Specified flows into or out of the active model grid define the conditions on all boundaries except the southwest (outflow) boundary, which is simulated with head-dependent flow. In the transient flow model, streamflow infiltration was the major stress, and was variable in time and location. The models were calibrated by adjusting aquifer hydraulic properties to match simulated and observed heads or head differences using the parameter-estimation program incorporated in MODFLOW-2000. Various summary, regression, and inferential statistics, in addition to comparisons of model properties and simulated head to measured properties and head, were used to evaluate the model calibration. Model parameters estimated for the steady-state calibration included hydraulic conductivity for seven of nine hydrogeologic zones and a global value of vertical anisotropy. Parameters estimated for the transient calibration included specific yield for five of the seven hydrogeologic zones. The zones represent five rock units and parts of four rock units with abundant interbedded sediment. All estimates of hydraulic conductivity were nearly within 2 orders of magnitude of the maximum expected value in a range that exceeds 6 orders of magnitude. The estimate of vertical anisotropy was larger than the maximum expected value. All estimates of specific yield and their confidence intervals were within the ranges of values expected for aquifers, the range of values for porosity of basalt, and other estimates of specific yield for basalt. The steady-state model reasonably simulated the observed water-table altitude, orientation, and gradients. Simulation of transient flow conditions accurately reproduced observed changes in the flow system resulting from episodic infiltration from the Big Lost River and facilitated understanding and visualization of the relative importance of historical differences in infiltration in time and space. As described in a conceptual model, the numerical model simulations demonstrate flow that is (1) dominantly horizontal through interflow zones in basalt and vertical anisotropy resulting from contrasts in hydraulic conductivity of various types of basalt and the interbedded sediments, (2) temporally variable due to streamflow infiltration from the Big Lost River, and (3) moving downward downgradient of the INL. The numerical models were reparameterized, recalibrated, and analyzed to evaluate alternative conceptualizations or implementations of the conceptual model. The analysis of the reparameterized models revealed that little improvement in the model could come from alternative descriptions of sediment content, simulated aquifer thickness, streamflow infiltration, and vertical head distribution on the downgradient boundary. Of the alternative estimates of flow to or from the aquifer, only a 20 percent decrease in

Cultural Heritage Protection Issues In Leśnica, The Settlement Of Wrocław

NASA Astrophysics Data System (ADS)

Kononowicz, Alena

2015-09-01

Leśnica, today the settlement on the western edge of Wrocław, formerly was an independent town, located on a previously wooded area, with a linear street system. It developed in the Middle Ages around the castle and church playing a service role for the Silesian Piast court on their way to Legnica and during hunting. In the thirteenth century it received city rights, and lost them in the eighteenth century. After the Piast dynasty had died out, it was sold by John of Luxembourg, and repeatedly changed its owners. In the nineteenth century it developed thanks to the industry, tourism and a convenient railway connection to Wrocław as well as hotel and restaurant facilities. In 1928, Leśnica was incorporated into Wrocław. After the Second World War, it lost its cultural continuity. In the 1970's, middle-heigh and high prefabricated buildings were built in the vicinity of a residential district. At the end of the twentieth and early twenty-first century, local industries were liquidated, and intensive land development started, causing the systematic blurring of its small-town character and its urban space started to acquire a character of a big city. In 2004, the old part of Leśnica was entered in the Register of Monuments. Also a ring road was planned, moving the cumbersome and dangerous transit traffic away from historic Średzka Street beyond the southern border of the settlement.

Ground-water quality in east-central Idaho valleys

USGS Publications Warehouse

Parliman, D.J.

1982-01-01

From May through November 1978, water quality, geologic, and hydrologic data were collected for 108 wells in the Lemhi, Pahsimeroi, Salman River (Stanley to Salmon), Big Lost River, and Little Lost River valleys in east-central Idaho. Data were assembled to define, on a reconnaissance level, water-quality conditions in major aquifers and to develop an understanding of factors that affected conditions in 1978 and could affect future ground-water quality. Water-quality characteristics determined include specific conductance, pH, water temperature, major dissolved cations, major dissolved anions, and coliform bacteria. Concentrations of hardness, nitrite plus nitrate, coliform bacteria, dissolved solids, sulfate, chloride, fluoride , iron, calcium, magnesium, sodium, potassium or bicarbonate exceed public drinking water regulation limits or were anomalously high in some water samples. Highly mineralized ground water probably is due to the natural composition of the aquifers and not to surface contamination. Concentrations of coliform bacteria that exceed public drinking water limits and anomalously high dissolved nitrite-plus-nitrite concentrations are from 15- to 20-year old irrigation wells in heavily irrigated or more densely populated areas of the valleys. Ground-water quality and quantity in most of the study area are sufficient to meet current (1978) population and economic demands. Ground water in all valleys is characterized by significant concentrations of calcium, magnesium, and bicarbonate plus carbonate ions. Variations in the general trend of ground-water composition (especially in the Lemhi Valley) probably are most directly related to variability in aquifer lithology and proximity of sampling site to source of recharge. (USGS)

Association Between Low Trough Levels of Vedolizumab During Induction Therapy for Inflammatory Bowel Diseases and Need for Additional Doses Within 6 Months.

PubMed

Williet, Nicolas; Boschetti, Gilles; Fovet, Marion; Di Bernado, Thomas; Claudez, Pierre; Del Tedesco, Emilie; Jarlot, Camille; Rinaldi, Leslie; Berger, Anne; Phelip, Jean-Marc; Flourie, Bernard; Nancey, Stéphane; Paul, Stéphane; Roblin, Xavier

2017-11-01

We investigated whether serum trough levels of vedolizumab, a humanized monoclonal antibody against integrin α4β7, during the induction phase of treatment can determine whether patients will need additional doses (optimization of therapy) within the first 6 months. We conducted an observational study of 47 consecutive patients with Crohn's disease (CD; n = 31) or ulcerative colitis (UC; n = 16) who had not responded to 2 previous treatment regimens with antagonists of tumor necrosis factor and were starting therapy with vedolizumab at 2 hospitals in France, from June 2014 through April 2016. All patients were given a 300-mg infusion of vedolizumab at the start of the study, Week 2, Week 6, and then every 8 weeks; patients were also given corticosteroids during the first 4-6 weeks. Patients not in remission at Week 6 were given additional doses of vedolizumab at Week 10 and then every 4 weeks (extended therapy or optimization). Remission at Week 6 of treatment was defined as CD activity score below 150 points for patients with CD and a partial Mayo Clinic score of <3 points, without concomitant corticosteroids, for patients with UC. Blood samples were collected each week and serum levels of vedolizumab and antibodies against vedolizumab were measured using an enzyme-linked immunosorbent assay. Median trough levels of vedolizumab and interquartile ranges were compared using the nonparametric Mann-Whitney test. The primary objective was to determine whether trough levels of vedolizumab measured during the first 6 weeks of induction therapy associated with the need for extended treatment within the first 6 months. Based on response to therapy at Week 6, extended treatment was required for 30 of the 47 patients (23 patients with CD and 7 patients with UC). At Week 2, trough levels of vedolizumab for patients selected for extended treatment were 23.0 μg/mL (interquartile range, 14.0-37.0 μg/mL), compared with 42.5 μg/mL in patients who did not receive extended treatment (interquartile range, 33.5-50.7; P = .15). At Week 6, trough levels of vedolizumab <18.5 μg/mL were associated with need for extended therapy (100% positive predictive value, 46.2%; negative predictive value; area under the receiver operating characteristic curve, 0.72) within the first 6 months. Among patients who required extended treatment at Week 10, all of those with trough levels of vedolizumab <19.0 μg/mL at Week 6 had achieved clinical remission 4 weeks later (secondary responders). In a prospective study of patients with CD or UC receiving induction therapy with vedolizumab, low trough levels of vedolizumab at Week 6 (<19.0 μg/mL) are associated with need for additional doses (given at Week 10 and then every 4 weeks). All patients receiving these additional doses achieved a clinical response 4 weeks later. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Exploring Unconventional Hydrocarbons in the Makó Trough, Pannonian basin, Hungary: Results and Challenges

NASA Astrophysics Data System (ADS)

Horvath, Anita; Bada, Gabor; Szafian, Peter; Sztano, Orsolya; Law, Ben; Wallis, Rod

2010-05-01

The latest phase exploration in the Makó Trough, which commenced a few years ago, has focused on the utilization of unconventional hydrocarbons. Accumulations are regarded as "unconventional" when they cannot be produced economically except by means of some sort of stimulation, usually hydraulic fracturing. The model we have developed for the evaluation of the hydrocarbon potential indicates a significant gas accumulation in the area of the Makó Trough. The tally of the distinctive attributes of the hydrocarbon system and the combined analysis of the available geological data led to the conclusion that the Makó Trough represents an area of active basin-centered gas accumulation (BCGA), with very significant perspective reserves. In a BCGA, hydrocarbons do not accumulate conventionally, in structural or stratigraphic traps, but rather in cells. Due to the geological setting of the Makó Trough, the hydrocarbon cell here forms a relatively continuous zone marked by considerable internal lithological and petrophysical variability. The most prolific parts, called sweet spots, possess a reservoir potential higher than the average. The identification of these sweet spots constitutes one of the most important, and quite possibly the most challenging task of the entire exploration project. The hemipelagic Endrőd Formation, which acts as the source rock, contains organic-rich marls in a depth delimited by the 170-230 °C isotherms. These marls constitute the still active hydrocarbon "kitchen" of the BCGA in the Makó Trough. The top and bottom boundaries of the cell essentially coincide with the turbidites of the Szolnok Formation and the top of the pre-Neogene basement, respectively. In light of the fact that pressure, temperature, and maturity tests have produced rather similar results in a number of wells in the area, we have reason to believe that the extension of the Makó Trough's BCGA is of regional dimensions (>1000 km2). The thickness and lateral extension of the potential reservoirs yield a cell volume as great as several hundred km3 - the largest single prospective gas occurrence in Hungary to date. Due to its novelty and complexity, the exploration of this unconventional resource demands the concurrent application of a wider range of geological and geophysical methods. In this presentation, we use selected examples to give an idea of where we stand on the way toward understanding the Makó Trough, particularly in terms of the geometric and structural features of the basin, the depositional (basin-fill) processes, and of the maturation history and accumulation properties of hydrocarbons. The geophysical surveys were purpose-designed to enable the mapping of the deep sedimentary trough and the sediments deposited in it. The data acquired to date suggest that the basin-centered gas accumulation occurred in the Lower Pannonian strata (11-6? Ma). Interpreting the 3D seismic data, the structural features and sedimentology of the basin can be studied in excellent resolution, while the integration of the seismic information with the geological data obtained from the wells allows us to interpret local well information extensively to gain a deeper, three-dimensional understanding of the basin. The sedimentary sequence filling up the Makó Trough displays distinct stratigraphic units separated by unconformities. Mapping the top of the pre-Neogene basement provides valuable insight into the nature of the paleo-geomorphological elements and the sedimentary environment at the onset of rifting. Paleontological information dates the syn-rift sediments of the trough to the Late Miocene (Early Pannonian), suggesting that the most intensive phase of basin evolution here was delayed by a few million years compared to adjacent areas. For the environmental reconstruction of the post-rift sedimentary sequence, we start with the assumption that initially a starved basin existed here, where sedimentation could not keep up with the rate of subsidence (Endrőd Formation). The basin was then almost completely filled by the turbidites of a prograding delta system (Szolnok Formation), followed by the sediments from the pro-delta (Algyő Formation) and the delta plain (Újfalu Formation). During the Plio- and Pleistocene, the area continued to subside at a decreased rate, providing a limited accumulation space filled by a thick sequence of alluvial deposits similar to the paleo-environment of the Tisza River and its tributaries prior to regulation. Our modeling of basin evolution in terms of subsidence, thermal and maturation history based on the results of geochemical, petrophysical, and paleontological investigations reveals that the organic matter accumulated in the trough underwent exceptionally rapid maturation during the last 5 to 7 million years. In fact, source rocks continue to mature at present time, and the hydrocarbons they generate continue to migrate and trap. The rather young age of the Pannonian Basin and its hydrocarbon system makes it quite different from the other examples of basin-centered gas accumulation, such as the classic Rocky Mountains in the U.S., or the Karoo Basin in South Africa, the Beetaloo Basin in Australia, making up the exploration portfolio of Falcon.

Pushing concentration of stationary solar concentrators to the limit.

PubMed

Winston, Roland; Zhang, Weiya

2010-04-26

We give the theoretical limit of concentration allowed by nonimaging optics for stationary solar concentrators after reviewing sun- earth geometry in direction cosine space. We then discuss the design principles that we follow to approach the maximum concentration along with examples including a hollow CPC trough, a dielectric CPC trough, and a 3D dielectric stationary solar concentrator which concentrates sun light four times (4x), eight hours per day year around.

Pushing concentration of stationary solar concentrators to the limit.

PubMed

Winston, Roland; Zhang, Weiya

2010-04-26

We give the theoretical limit of concentration allowed by nonimaging optics for stationary solar concentrators after reviewing sun-earth geometry in direction cosine space. We then discuss the design principles that we follow to approach the maximum concentration along with examples including a hollow CPC trough, a dielectric CPC trough, and a 3D dielectric stationary solar concentrator which concentrates sun light four times (4x), eight hours per day year around.

Exact analytic flux distributions for two-dimensional solar concentrators.

PubMed

Fraidenraich, Naum; Henrique de Oliveira Pedrosa Filho, Manoel; Vilela, Olga C; Gordon, Jeffrey M

2013-07-01

A new approach for representing and evaluating the flux density distribution on the absorbers of two-dimensional imaging solar concentrators is presented. The formalism accommodates any realistic solar radiance and concentrator optical error distribution. The solutions obviate the need for raytracing, and are physically transparent. Examples illustrating the method's versatility are presented for parabolic trough mirrors with both planar and tubular absorbers, Fresnel reflectors with tubular absorbers, and V-trough mirrors with planar absorbers.

Development of sheet-metal parabolic-trough reflector panels

NASA Astrophysics Data System (ADS)

Biester, A. W.

1982-06-01

Efforts to develop accurate, durable, and mass producible sheet metal parabolic trough solar collectors and the associated support for the collectors are described. The design considered is similar to an automobile hood, a two-piece sheet metal structure consisting of a formed steel frame or stiffening panel and a smooth contoured skin. The two pieces may be bonded or welded to form a rigid structure, and a reflective surface applied such as a film, glass mirror, or any of the presently utilized materials. The work encompassed material selection, adhesive selection and testing, tool design and fabrication, prototype panel production, and design and development of torque tube assemblies on which the trough is inclined. Results of adhesive bonding studies are given. It is found that high volume technology can be used to produce accurate and structurally sound reflector panels, and one configuration was selected for fabrication in suitable quantities for performance testing.

Interseismic Coupling-Based Earthquake and Tsunami Scenarios for the Nankai Trough

NASA Astrophysics Data System (ADS)

Baranes, H.; Woodruff, J. D.; Loveless, J. P.; Hyodo, M.

2018-04-01

Theoretical modeling and investigations of recent subduction zone earthquakes show that geodetic estimates of interseismic coupling and the spatial distribution of coseismic rupture are correlated. However, the utility of contemporary coupling in guiding construction of rupture scenarios has not been evaluated on the world's most hazardous faults. Here we demonstrate methods for scaling coupling to slip to create rupture models for southwestern Japan's Nankai Trough. Results show that coupling-based models produce distributions of ground surface deformation and tsunami inundation that are similar to historical and geologic records of the largest known Nankai earthquake in CE 1707 and to an independent, quasi-dynamic rupture model. Notably, these models and records all support focused subsidence around western Shikoku that makes the region particularly vulnerable to flooding. Results imply that contemporary coupling mirrors the slip distribution of a full-margin, 1707-type rupture, and Global Positioning System measurements of surface motion are connected with the trough's physical characteristics.

Development and Testing of a Power Trough System Using a Structurally-Efficient, High-Performance, Large-Aperture Concentrator with Thin Glass Reflector and Focal Point Rotation

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, E. K.; Forristall, R.

2005-11-01

Industrial Solar Technology has assembled a team of experts to develop a large-aperture parabolic trough for the electric power market that moves beyond cost and operating limitations of 1980's designs based on sagged glass reflectors. IST's structurally efficient space frame design will require nearly 50% less material per square meter than a Solel LS-2 concentrator and the new trough will rotate around the focal point. This feature eliminates flexhoses that increase pump power, installation and maintenance costs. IST aims to deliver a concentrator module costing less than $100 per square meter that can produce temperatures up to 400 C. Themore » IST concentrator is ideally suited for application of front surface film reflectors and ensures that US corporations will manufacture major components, except for the high temperature receivers.« less

Gas Forming a V-Shape Aluminum Sheet into a Trough of Saddle-Contour

NASA Astrophysics Data System (ADS)

Lee, Shyong; Lan, Hsien-Chin; Lee, Jye; Wang, Jian-Yih; Huang, J. C.; Chu, Chun Lin

2012-11-01

A sheet metal trough of aluminum alloys is manufactured by gas-forming process at 500 °C. The product with slope walls is of ~1.2 m long and ~260 mm opening width, comprising two conical sinks at two ends. The depth of one sink apex is ~350 mm, which results in the depth/width ratio reaching 1.4. To form such a complex shape with high aspect ratio, a pre-form of V-shape groove is prepared prior to the gas-forming work. When this double concave trough is turned upside down, the convex contour resembles the back of a twin hump camel. The formability of this configuration depends on the gas pressurization rate profile, the working temperature, material's micro-structure, as well as pre-form design. The latter point is demonstrated by comparing two aluminum alloys, AA5182 and SP5083, with nearly same compositions but very different grain sizes.

Chronology of Miocene-Pliocene deposits at Split Mountain Gorge, Southern California: A record of regional tectonics and Colorado River evolution

USGS Publications Warehouse

Dorsey, R.J.; Fluette, A.; McDougall, K.; Housen, B.A.; Janecke, S.U.; Axen, G.J.; Shirvell, C.R.

2007-01-01

Late Miocene to early Pliocene deposit at Split Mountain Gorge, California, preserve a record of basinal response to changes in regional tectonics, paleogeography, and evolution of the Colorado River. The base of the Elephant Trees Formation, magnetostratigraphically dated as 8.1 ?? 0.4 Ma, provides the earliest well-dated record of extension in the southwestern Salton Trough. The oldest marine sediments are ca. 6.3 Ma. The nearly synchronous timing of marine incursion in the Salton Trough and northern Gulf of California region supports a model for localization of Pacific-North America plate motion in the Gulf ca. 6 Ma. The first appearance of Colorado River sand at the Miocene-Pliocene boundary (5.33 Ma) suggests rapid propagation of the river to the Salton Trough, and supports a lake-spillover hypothesis for initiation of the lower Colorado River. ?? 2007 Geological Society of America.

Sensitivity analysis on the effect of key parameters on the performance of parabolic trough solar collectors

NASA Astrophysics Data System (ADS)

Muhlen, Luis S. W.; Najafi, Behzad; Rinaldi, Fabio; Marchesi, Renzo

2014-04-01

Solar troughs are amongst the most commonly used technologies for collecting solar thermal energy and any attempt to increase the performance of these systems is welcomed. In the present study a parabolic solar trough is simulated using a one dimensional finite element model in which the energy balances for the fluid, the absorber and the envelope in each element are performed. The developed model is then validated using the available experimental data . A sensitivity analysis is performed in the next step in order to study the effect of changing the type of the working fluid and the corresponding Reynolds number on the overall performance of the system. The potential improvement due to the addition of a shield on the upper half of the annulus and enhancing the convection coefficient of the heat transfer fluid is also studied.

The Valencia trough and the origin of the western Mediterranean basins

NASA Astrophysics Data System (ADS)

Vegas, R.

1992-03-01

Evolutionary models for the Valencia trough must be necessarily related to the Neogene-Present geodynamics of the western Mediterranean basins. All these basins occupy new space created in the wake of the westward translation of the Alboran block and the counter-clockwise rotation of the Corso-Sardinian block. This escape-tectonics, microplate dispersal, model can account for the co-existence and progressive migration of compressional and extensional strain fields within the Africa-Europe broad zone of convergence. In this escape-tectonics model, the Valencia trough has resulted in a complex evolution which includes: (1) latest Oligocene-Early Miocene rifting along the Catalan-Valencian margin due to the opening of the Gulf of Lions; (2) almost simultaneous, Early Miocene, transpressive thrusting in the Balearic margin related to the initiation of displacement of the Alboran block; and (3) Late Miocene generalized extension as a consequence of the opening of the South Balearic basin.

Slide Conveying of Granular Materials-Thinking Out of the Glovebox

NASA Technical Reports Server (NTRS)

Goddard, J. D.; Didwania, A. K.; Nott, P. R.

2000-01-01

The vibratory conveyor, routinely employed for normal-gravity transport of granular materials, usually consists of a continuous open trough vibrated sinusoidally to induce axial movement of a granular material. Motivated in part by a hypothetical application in zero gravity, we propose a novel modification of the vibratory conveyor based on a closed 2d trough operating in a "slide-conveying" mode, with the granular mass remaining permanently in contact with the trough walls. We present a detailed analysis of the mechanics of transport, based on a rigid-slab model for the granular mass with frictional (Coulomb) slip at the upper and lower walls. The form of the vibration cycle plays a crucial role, and the optimal conveying cycle is not the commonly assumed rectilinear sinusoidal motion. The conveying efficiency for the novel slide conveyor will be presented for several simple vibration cycles, including one believed to represent the theoretical optimum.

Plasmaspheric Erosion via Plasmasphere Coupling to Ring Current Plasmas: EUV Observations and Modeling

NASA Technical Reports Server (NTRS)

Adrian, M. L.; Gallagher, D. L.; Khazanov, G. V.; Chsang, S. W.; Liemohn, M. W.; Perez, J. D.; Green, J. L.; Sandel, B. R.; Mitchell, D. G.; Mende, S. B.;

Second Generation Novel High Temperature Commercial Receiver & Low Cost High Performance Mirror Collector for Parabolic Solar Trough

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stettenheim, Joel

Norwich Technologies (NT) is developing a disruptively superior solar field for trough concentrating solar power (CSP). Troughs are the leading CSP technology (85% of installed capacity), being highly deployable and similar to photovoltaic (PV) systems for siting. NT has developed the SunTrap receiver, a disruptive alternative to vacuum-tube concentrating solar power (CSP) receivers, a market currently dominated by the Schott PTR-70. The SunTrap receiver will (1) operate at higher temperature (T) by using an insulated, recessed radiation-collection system to overcome the energy losses that plague vacuum-tube receivers at high T, (2) decrease acquisition costs via simpler structure, and (3) dramaticallymore » increase reliability by eliminating vacuum. It offers comparable optical efficiency with thermal loss reduction from ≥ 26% (at presently standard T) to ≥ 55% (at high T), lower acquisition costs, and near-zero O&M costs.« less

Coincident observations of ionospheric troughs and the equatorial plasmapause

NASA Technical Reports Server (NTRS)

Grebowsky, J. M.; Maynard, N. C.; Tulunay, Y. K.; Lanzerotti, L. J.

1976-01-01

Electron-density observations made in the topside ionosphere by the Ariel 4 and Isis 2 satellites are examined in conjunction with results obtained by Explorer 45 when it traversed the near-equatorial plasmapause with one hour (both UT and MLT) of the Ariel and Isis traversals of the same L coordinate. Both dusk and night observations are analyzed, and an attempt is made to show that depressions in ionospheric electron density occur in the vicinity of the plasmapause field line. It is concluded that the electron distributions observed in the electron-density troughs at 550 km near dusk by Ariel and at 1400 km near midnight by Isis do not always parallel variations in the light-ion distribution inferred from the Explorer plasmapause traversals and that there appears to be no specific feature of the main ionospheric trough which can be used to identify the plasmapause field line except in a statistical sense.

A new TRNSYS component for parabolic trough collector simulation

NASA Astrophysics Data System (ADS)

Drosou, Vassiliki; Valenzuela, Loreto; Dimoudi, Argiro

2018-03-01

This study describes and evaluates a new simulation component for parabolic trough collectors (PTCs). The new simulation component is implemented in the TRNSYS software environment by means of new Type that is suitable for integration into the calculation of a whole concentrating solar thermal plant, in order to evaluate the energy production of a PTC. The main advantage of the new Type is that is derived from experimental data available on efficiency Test Reports, according to the current European and International standards, rather than the theoretical approach considered in the existing parabolic trough component of TRNSYS library. The performance of the new Type has been validated with real experimental data obtained from the DISS solar test loop in Plataforma Solar de Almería, Spain. The paper describes the modelling approach, presents the comparison of simulation results with measurements taken at the DISS facility and evaluates the results.

Airborne Lidar measurements of the atmospheric pressure profile with tunable Alexandrite lasers

NASA Technical Reports Server (NTRS)

Korb, C. L.; Schwemmer, G. K.; Dombrowski, M.; Milrod, J.; Walden, H.

1986-01-01

The first remote measurements of the atmospheric pressure profile made from an airborne platform are described. The measurements utilize a differential absorption lidar and tunable solid state Alexandrite lasers. The pressure measurement technique uses a high resolution oxygen A band where the absorption is highly pressure sensitive due to collision broadening. Absorption troughs and regions of minimum absorption were used between pairs of stongly absorption lines for these measurements. The trough technique allows the measurement to be greatly desensitized to the effects of laser frequency instabilities. The lidar system was set up to measure pressure with the on-line laser tuned to the absorption trough at 13147.3/cm and with the reference laser tuned to a nonabsorbing frequency near 13170.0/cm. The lidar signal returns were sampled with a 200 range gate (30 vertical resoltion) and averaged over 100 shots.

Constraining back-arc basin formation in the eastern Coral Sea: preliminary results from the ECOSAT voyage

NASA Astrophysics Data System (ADS)

Seton, M.; Williams, S.; Mortimer, N. N.; Meffre, S.; Moore, J.; Micklethwaite, S.; Zahirovic, S.

2013-12-01

The eastern Coral Sea region is an underexplored area at the northeastern corner of the Australian plate, where long-lived interaction between the Pacific and Australian plate boundaries has resulted in an intricate assemblage of deep oceanic basins and ridges, continental fragments and volcanic products. A paucity of marine geophysical and geological data from this complex region has resulted in the lack of a clear conceptual framework to describe its formation, ultimately affecting our understanding of the connection between the plate boundaries of the SW Pacific and SE Asia. In particular, the tectonic relationship between two back-arc basins, the Santa Cruz and d'Entrecasteaux Basins, and the South Rennell Trough, has yet to be resolved. In October-November, 2012, we collected 6,200 km of marine magnetic, 6,800 km of gravity and over 13,600 km2 of swath bathymetry data from the eastern Coral Sea onboard the RV Southern Surveyor. A complementary dredging program yielded useful samples from 14 seafloor sites. Our preliminary geochemical interpretation of the dredge samples obtained from the South Rennell Trough reveal volcanic rocks resembling MORB or BABB-type basalts, similar in composition to the recently re-analysed and dated ORSTOM dredges from the area that yielded ~28 Ma MORB-like basalts. Swath bathymetry profiles from the Santa Cruz Basin reveal that the South Rennell Trough extends into this basin, with seafloor spreading fabric being parallel to the trough. Preliminary analysis of the three full and four partial new magnetic anomaly profiles across the Santa Cruz Basin, coupled with limited existing profiles, reveals that the basin may have formed between Chrons 13-18 (~32-38 Ma), with an extinct spreading ridge along the inferred continuation of the South Rennell Trough, consistent with ORSTOM age dates. Our results suggest that the South Rennell Trough is an extinct southwestward propagating spreading ridge, which may have initiated along a pre-existing zone of weakness. A preliminary interpretation of the 4 magnetic profiles collected in the d'Entrecasteaux Basin and existing profiles of seafloor fabric shows that this basin does not share a common seafloor spreading history with the Santa Cruz Basin, as has been suggested previously. Our preliminary interpretation of the relationship between the Santa Cruz Basin, South Rennell Trough and d'Entrecasteaux Basin requires a re-interpretation of existing models of the SW Pacific to take into account a southwestward propagating spreading ridge between 38-32 Ma, contemporaneous with seafloor spreading further south in the North Loyalty Basin. Further work on age-dating and geochemical analysis of the newly collected dredge samples and an in-depth analysis of the magnetic anomalies in the d'Entrecasteaux Basin may further yield important information concerning the tectonic evolution of the area.

Deep drivers of mesoscale circulation in the central Rockall Trough

NASA Astrophysics Data System (ADS)

Sherwin, T. J.; Alyenik, D.; Dumont, E.; Inall, M.

2014-11-01

Mesoscale variability in the central Rockall Trough between about 56 and 58° N has been investigated using a combination of ship-borne, underwater glider and gridded satellite altimeter measurements. Altimeter observations show that mesoscale features such as eddies and large scale circulation cells are ubiquitous phenomena. They have horizontal length scales of order 100 km with vertical scales of over 1000 m and are associated with mean current speeds (over the upper 1000 m) of 15 ± 7 cm s-1. Monthly area averaged surface Eddy Kinetic Energy (EKE) has substantial inter-annual variability, which at times can dominate a mean seasonal signal that varies from a maximum in May (74 cm2 s-2) to a minimum in October (52 cm2 s-2) and has increased gradually since 1992 at about 1.1 cm2 s-2 per year. A five month glider mission in the Trough showed that much of this energy comes from features that are located over 1000 m below the surface in the deep cold waters of the Trough (possibly from eddies associated the North Atlantic Current). The surface currents from altimeters had similar magnitude to the drift currents averaged over 1000 m from the glider in the stratified autumn, but were half the deep water speed during late winter. Although the mesoscale features move in an apparent random manner they may also be quasi-trapped by submarine topography such as seamounts. Occasionally anti-cyclonic and cyclonic cells combine to cause a coherent westward deflection of the European slope current that warms the Rockall side of the Trough. Such deflections contribute to the inter-annual variability in the observed temperature and salinity that are monitored in the upper 800 m of the Trough. By combining glider and altimeter measurements it is shown that altimeter measurements fail to observe a 15 cm s-1 northward flowing slope current on the eastern side and a small persistent southward current on the western side. There is much to be gained from the synergy between satellite altimetry and in situ glider observations both in the interpretation of their separate data sets and in aiding glider pilots to steer their vehicles through EKE active regions such as the north-east Atlantic.

The role of water in the petrogenesis of Marina trough magmas

NASA Astrophysics Data System (ADS)

Stolper, Edward; Newman, Sally

1994-02-01

Most variations in composition among primitive basalts from the Mariana back-arc trough can be explained by melting mixtures of an N-type mid-ocean ridge basalt (NMORB) mantle source and an H2O rich component, provided the degree of melting is positively and approximately linearly correlated with the proportion of the H2O-rich component in the mixture. We conclude that the degrees of melting by which Mariana trough magmas are generated increase from magmas similar to NMORB, through more H2O-enriched basalts, to 'arc-like' basalts, and that this increase is due to the lowering of the solidus of mantle peridotite that accompanies addition of the H2O-rich component. The H2O-rich component is likely to be ultimately derived from fluid from a subducting slab, but we propose that by the time fluids reach the source regions of Mariana trough basalts, they have interacted with sufficient mantle material that for all but the most incompatible of elements (with respect to fluid-mantle interaction), they are in equilibrium with the mantle. In contrast, fluids added to the source regions of Mariana island-arc magmas have typically interacted with less mantle and thus retain the signature of slab-derived fluids to varying degrees for all but the most compatible elements. Primitive Mariana arc basalts can be generated by melting mixtures of such incompletely exchanged slab-derived fluids and sources similar to NMORB-type mantle sources, but the degrees of melting are typically higher than those of Mariana trough NMORB and the sources have been variably depleted relative to the back-arc sources by previous melt extraction. This depletion may be related to earlier extraction of back-arc basin magmas or may evolve by repeated fluxing of the sources as fluid is continually added to them in the regions of arc magma generation. If fluid with partitioning behavior relative to the solid mantle similar to that deduced for the H2O-rich component involved in the generation of Mariana trough basalts were extracted from primitive mantle, the residual mantle would have many of the minor and trace element characteristics of typical oceanic upper mantle; primitive mantle enriched in such fluid would be a satisfactory source for the continental crust in terms of its trace and minor element chemical composition.

Quaternary Turbidite Sedimentation in the Moresby Trough, Preliminary Observations from the Papua New Guinea S2S Study Area

NASA Astrophysics Data System (ADS)

Bentley, S. J.; Muhammad, Z.; Dickens, J.; Droxler, A.; Peterson, L.; Opdyke, B.

2004-12-01

Multicores and jumbo piston cores were collected from the Moresby Trough from the R/V Melville in March-April 204 to study patterns of off-shelf sediment flux from the Gulf of Papua to the deep sea over Pleistocene-Holocene timescales. The Moresby Trough represents the primary deep-sea sediment conduit linking the Source to Sink Gulf of Papua study area to the north with the Coral Sea Basin to the south. Core locations were navigated from the surface using dynamic positioning and multibeam bathymetric mosaics collected during the cruise. Selected cores have been analyzed using a multi-sensor core logger, X-radiography, granulometry, and Pb-210 geochronology. Most piston cores collected from the Moresby Trough contain abundant mafic sandy turbidites overlain by fine-grained hemipelagic deposits 1-2 m thick. X-radiographs of multicores reveal mostly bioturbated hemipelagics. However, one core, MV25-0403-24MC, was collected from the axis of a primary channel, and contains at least two fine-grained turbidites within the upper 0.5 m of sediment. The uppermost turbidite contains low but uniform activities of excess Pb-210, and may have been 15-20 cm thick at the time of deposition (i.e., before subsequent disruption by bioturbation), based on fabric and radiochemical evidence. Application of a simple box-model for physical mixing (i.e., during the flow) and subsequent decay suggests that the uppermost turbidite was deposited 70-120 years before present. Bioturbation has since reworked about 60% of the bed, suggesting that such beds will only escape destruction by bioturbation if they are > 10 cm thick, and are deposited more frequently than once per century. Based on these observations, we suggest that gravity flows are presently active in the Moresby trough, and may account for a significant fraction of the hemipelagic drape present in channel systems. However, fabric evidence for these thin, fine-grained beds may be obscured by subsequent bioturbation. Also, at some point in the past, possibly at the onset of the Holocene Transgression, the character of sediment flux to the Moresby Trough shifted from sandy mafic-rich sandy turbidity currents to much finer sediments, delivered downslope by both benthic flows and vertical flux through the water column.

Shielded serpentine traveling wave tube deflection structure

DOEpatents

Hudson, C.L.; Spector, J.

1994-12-27

A shielded serpentine slow wave deflection structure is disclosed having a serpentine signal conductor within a channel groove. The channel groove is formed by a serpentine channel in a trough plate and a ground plane. The serpentine signal conductor is supported at its ends by coaxial feed through connectors. A beam interaction trough intersects the channel groove to form a plurality of beam interaction regions wherein an electron beam may be deflected relative to the serpentine signal conductor. 4 figures.

DETAIL VIEW OF CLASSIFIER, TAILINGS LAUNDER TROUGH, LINE SHAFTS, AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF CLASSIFIER, TAILINGS LAUNDER TROUGH, LINE SHAFTS, AND CONCENTRATION TABLES, LOOKING SOUTHWEST. SLURRY EXITING THE BALL MILL WAS COLLECTED IN AN AMALGAMATION BOX (MISSING) FROM THE END OF THE MILL, AND INTRODUCED INTO THE CLASSIFIER. THE TAILINGS LAUDER IS ON THE GROUND AT LOWER RIGHT. THE LINE SHAFTING ABOVE PROVIDED POWER TO THE CONCENTRATION TABLES BELOW AT CENTER RIGHT. - Gold Hill Mill, Warm Spring Canyon Road, Death Valley Junction, Inyo County, CA

Fate and Transport of Tungsten at Camp Edwards Small Arms Ranges

DTIC Science & Technology

2007-08-01

area into the lower berm and/or trough. A similar approach was used in the lower berm area with samples collected from soil sloughing from the...bucket au- ger to collect samples beneath the bullet pockets and the trough. A multi - increment, subsurface soil sample was made by combining the...range. From these soil profiles, a total of 72 multi -increment subsurface soil sam- ples was collected (Table 2). The auger was cleaned between holes

DETAIL VIEW OF BALL MILL FEED SYSTEM, MOUTH OF CLASSIFIER, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF BALL MILL FEED SYSTEM, MOUTH OF CLASSIFIER, AND ORE BIN CHUTE, LOOKING EAST NORTHEAST. CRUSHED ORE FROM THE SECONDARY ORE BIN WAS INTRODUCED INTO THE FEED TROUGH VIA A CHUTE. AS THE BALL MILL TURNED, THE ROUND SCOOP ALSO TURNED IN THE TROUGH TO CHANNEL ORE INTO THE BALL MILL. SEE CA-292-14 FOR IDENTICAL B&W NEGATIVE. - Gold Hill Mill, Warm Spring Canyon Road, Death Valley Junction, Inyo County, CA

DETAIL VIEW OF BALL MILL FEED SYSTEM, MOUTH OF CLASSIFIER, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF BALL MILL FEED SYSTEM, MOUTH OF CLASSIFIER, AND ORE BIN CHUTE, LOOKING EAST NORTHEAST. CRUSHED ORE FROM THE SECONDARY ORE BIN WAS INTRODUCED INTO THE FEED TROUGH VIA A CHUTE. AS THE BALL MILL TURNED, THE ROUND SCOOP ALSO TURNED IN THE TROUGH TO CHANNEL ORE INTO THE BALL MILL. SEE CA-292-20 (CT) FOR IDENTICAL COLOR TRANSPARENCY. - Gold Hill Mill, Warm Spring Canyon Road, Death Valley Junction, Inyo County, CA

Bottom-water observations in the Vema fracture zone

NASA Astrophysics Data System (ADS)

Eittreim, Stephen L.; Biscaye, Pierre E.; Jacobs, Stanley S.

1983-03-01

The Vema fracture zone trough, at 11°N between 41° and 45°E, is open to the west at the 5000-m level but is silled at the 4650-m level on the east where it intersects the axis of the Mid-Atlantic Ridge. The trough is filled with Antarctic Bottom Water (AABW) with a potential temperature of 1.32°C and salinity of 34.82 ppt. The bottom water is thermally well mixed in a nearly homogeneous layer about 700 m thick. The great thickness of this bottom layer, as compared with the bottom-water structure of the western Atlantic basin, may result from enhanced mixing induced by topographic constriction at the west end of the fracture zone trough. A benthic thermocline, with potential temperature gradients of about 1.2 mdeg m-1, is associated with an abrupt increase in turbidity with depth at about 1200 m above bottom. A transitional layer of more moderate temperature gradients, about 0.4 mdeg m-1, lies between the benthic thermocline above and the AABW below. The AABW layer whose depth-averaged suspended paniculate concentrations range from 8 to 19 μg L-1, is consistently higher in turbidity than the overlying waters. At the eastern end of the trough, 140 m below sill depth, very low northeastward current velocities, with maximums of 3 cm s-1, were recorded for an 11-day period.

Is the oceanic heat flux on the central Amundsen sea shelf caused by barotropic or baroclinic currents?

NASA Astrophysics Data System (ADS)

Kalén, Ola; Assmann, Karen M.; Wåhlin, Anna K.; Ha, Ho Kyung; Kim, Tae Wan; Lee, Sang Hoon

2016-01-01

The glaciers that drain the West Antarctic Ice Sheet into the Amundsen Sea are accelerating and experiencing increased basal melt of the floating ice shelves. Warm and salty deep water has been observed to flow southward in deep troughs leading from the shelf break to the inner shelf area where the glaciers terminate. It has been suggested that the melting induced by this warm water is responsible for the acceleration of the glaciers. Here we investigate the structure of the currents and the associated heat flow on the shelf using in-situ observations from 2008 to 2014 in Dotson Trough, the main channel in the western part of the Amundsen Sea shelf, together with output from a numerical model. The model is generally able to reproduce the observed velocities and temperatures in the trough, albeit with a thicker warm bottom layer. In the absence of measurements of sea surface height we define the barotropic component of the flow as the vertical average of the velocity. It is shown that the flow is dominated by warm barotropic inflows on the eastern side and colder and fresher barotropic outflows on the western side. The transport of heat appears to be primarily induced by this clockwise barotropic circulation in the trough, contrary to earlier studies emphasizing a bottom-intensified baroclinic inflow as the main contributor.

Experimental study on flowing burning behaviors of a pool fire with dripping of melted thermoplastics.

PubMed

Xie, Qiyuan; Tu, Ran; Wang, Nan; Ma, Xin; Jiang, Xi

2014-02-28

The objective of this work is to quantitatively investigate the dripping-burning and flowing fire of thermoplastics. A new experimental setup is developed with a heating vessel and a T-trough. Hot thermoplastic liquids are generated in the vessel by electric heating. N2 gas is continuously injected into the vessel to avoid a sudden ignition of fuel in it. The detailed flowing burning behaviors of pool fire in the T-trough are analyzed through the measurements of the mass, heat flux and temperatures etc. The experimental results suggest that a continuous dripping of melted thermoplastic liquids in a nearly constant mass rate can be successfully made in the new setup. It also shows that the mass dripping rate of melted PS liquid is smaller than PP and PE since its large viscosity. In addition, the flame spread velocities of hot liquids of PS in the T-trough are also smaller than that of PP and PE because of its large viscosity. The mass burning rate of the PP and PE pool fire in T-trough are smaller than PS. Finally, considering the heating, melting, dripping and flowing burning behaviors of these polymers, it is suggested that the fire hazard of PE and PP are obviously higher than PS for their faster flowing burning. Copyright © 2013 Elsevier B.V. All rights reserved.

Analysis of ground-motion simulation big data

NASA Astrophysics Data System (ADS)

Maeda, T.; Fujiwara, H.

2016-12-01

We developed a parallel distributed processing system which applies a big data analysis to the large-scale ground motion simulation data. The system uses ground-motion index values and earthquake scenario parameters as input. We used peak ground velocity value and velocity response spectra as the ground-motion index. The ground-motion index values are calculated from our simulation data. We used simulated long-period ground motion waveforms at about 80,000 meshes calculated by a three dimensional finite difference method based on 369 earthquake scenarios of a great earthquake in the Nankai Trough. These scenarios were constructed by considering the uncertainty of source model parameters such as source area, rupture starting point, asperity location, rupture velocity, fmax and slip function. We used these parameters as the earthquake scenario parameter. The system firstly carries out the clustering of the earthquake scenario in each mesh by the k-means method. The number of clusters is determined in advance using a hierarchical clustering by the Ward's method. The scenario clustering results are converted to the 1-D feature vector. The dimension of the feature vector is the number of scenario combination. If two scenarios belong to the same cluster the component of the feature vector is 1, and otherwise the component is 0. The feature vector shows a `response' of mesh to the assumed earthquake scenario group. Next, the system performs the clustering of the mesh by k-means method using the feature vector of each mesh previously obtained. Here the number of clusters is arbitrarily given. The clustering of scenarios and meshes are performed by parallel distributed processing with Hadoop and Spark, respectively. In this study, we divided the meshes into 20 clusters. The meshes in each cluster are geometrically concentrated. Thus this system can extract regions, in which the meshes have similar `response', as clusters. For each cluster, it is possible to determine particular scenario parameters which characterize the cluster. In other word, by utilizing this system, we can obtain critical scenario parameters of the ground-motion simulation for each evaluation point objectively. This research was supported by CREST, JST.

Seismic Stratigraphic Evidence From SE Ross Sea for Late Oligocene Glaciers and ice Streams Issuing From Marie Byrd Land

NASA Astrophysics Data System (ADS)

Sorlien, C. C.; Luyendyk, B. P.; Wilson, D. S.; Decesari, R. C.; Bartek, L. R.; Diebold, J. B.

2006-12-01

The extent of the West Antarctic ice sheet during mid-Cenozoic time is controversial and important to climate models. High-resolution multichannel seismic reflection data were acquired using the RVIB Palmer along the edge of the Ross Ice Shelf across the Eastern Basin of Ross Sea, in an area where calving of the ice shelf has exposed seafloor that has not been accessible to marine geophysics in several decades. A sub-basin in the far southeast corner of Ross Sea contains a succession of sediment-filled troughs, each capped by an unconformity. These troughs range between 2 and 20 km across, are 100 to 150 m-deep, with the narrower ones bounded by flat-topped ridges interpreted as moraines. We interpret the troughs interval to slightly predate 25 Ma. Reflections just 100 m below the troughs interval can be directly correlated to near DSDP270 where they underlie strata dated at ~25 Ma. A deeper stack of prograding sequences associated with a flat- topped ridge are interpreted as pre-25 Ma, possibly early Oligocene, deltas formed adjacent to the grounding line of a glacier, and the flat-topped ridge to be a moraine. The shallowest of the stack of unconformities capping the broad troughs can be projected across a basement ridge on trend with Roosevelt Island to a regional angular unconformity ("Red"), present across 70 km to deep sedimentary Eastern Basin. This unconformity represents about 1 km of missing stratigraphic section, is smooth and level, and splits into several major sequence boundaries within deep Eastern Basin. The second shallowest of these boundaries is dated about 14 Ma at DSDP-270. We interpret this unconformity to be cut by regional thick, grounded ice at depths several hundred meters below sea level. Pre-25 Ma strata show evidence of narrow erosional troughs and reflective mounds or ridges on the west flank of the basement ridge, but such features are not present in southern deep Eastern Basin near the ice shelf edge. This is evidence that the troughs were carved by glaciers issuing from distant highlands of Marie Byrd Land and not from East Antarctica. Late Oligocene through mid Miocene and younger prograding and unconformities farther north in Eastern Basin indicate grounded ice there. One possible interpretation is that "Red" was cut by thick, grounded ice that affected all of the Eastern Ross Sea paleo-shelf, while the pre-25 Ma glaciers affected only the area proximal to Marie Byrd Land. Late Oligocene glaciation on the outer shelf above deep Eastern Basin may have been sourced from East Antarctica and/or Central High. Evidence for pre-25 Ma glaciation proximal to Marie Byrd Land, combined with evidence for Oligocene ice caps at widely-separated localities of West Antarctica, allow the interpretation that portions of the West Antarctic Ice Sheet developed during Oligocene time. The broad troughs and the stack of prograding sequences may be related to dynamic ice caps and sea level falls in mid Oligocene and earliest Oligocene time. The Middle Miocene Red unconformity may be related to development of polar (cold-base) ice sheets. Oligocene glaciation implies that Marie Byrd Land and eastern Ross Sea have subsided from higher elevation due to cooling after late Cretaceous crustal thinning.

Main Ionospheric Trough and Equatorial Ionization Anomaly During Substorms With the Different UT Onset Moments

NASA Astrophysics Data System (ADS)

Klimenko, M. V.; Klimenko, V. V.; Bryukhanov, V. V.

2007-05-01

In the given work the numerical calculation results of ionospheric effects of four modeling substorms which have begun in 00, 06, 12 and 18 UT are presented. Calculations are executed on the basis of Global Self-consistent Model of the Thermosphere, Ionosphere and Protonosphere (GSM TIP), developed in WD IZMIRAN, added by the new block of calculation of electric fields in the ionosphere of the Earth for vernal equinox conditions in the minimum of solar activity. In calculations we considered superposition of magnetospheric convection electric field (at set potential differences through polar caps and field aligned currents of the second zone with taking into account of particle precipitation) and dynamo field generated by thermospheric winds without taking into account the tides. It is shown, that in the given statement of problem the substorms cause strong positive disturbances in F-region of ionosphere in night sector. Negative disturbances are much less and arise, mainly, at night in the middle and low latitudes. During substorms longitudinal extent of main ionospheric trough increases. The substorm beginning in 18 UT, causes negative disturbances in high latitudes except for a southern polar cap. Besides there is "stratification" of the main ionospheric trough. As a result in southern hemisphere the additional high-latitude trough which is absent in quiet conditions is formed. "Stratification" of the main ionospheric trough occurs in northern hemisphere at 6 hours after the beginning of the substorm. These "stratifications" are consequence non-stationary magnetospheric convection. Distinction between these events consists that "stratification" in a southern hemisphere occurs in active phase of substorm, and in northern hemisphere in recovery phase. During a substorm beginning in 00 UT, foF2 increases in all northern polar cap. Positive disturbances of foF2 in the equatorial anomaly region cause all presented substorms, except for a substorm beginning in 18 UT. This substorm causes small negative disturbances in the equatorial anomaly region in the Indian longitudinal sector.

The Salton Seismic Imaging Project (SSIP): Rift Processes and Earthquake Hazards in the Salton Trough (Invited)

NASA Astrophysics Data System (ADS)

Hole, J. A.; Stock, J. M.; Fuis, G. S.; Rymer, M. J.; Murphy, J. M.; Sickler, R. R.; Criley, C. J.; Goldman, M.; Catchings, R. D.; Ricketts, J. W.; Gonzalez-Fernandez, A.; Driscoll, N.; Kent, G.; Harding, A. J.; Klemperer, S. L.

2009-12-01

The Salton Seismic Imaging Project (SSIP) and coordinated projects will acquire seismic data in and across the Salton Trough in southern California and northern Mexico, including the Coachella, Imperial, and Mexicali Valleys. These projects address both rifting processes at the northern end of the Gulf of California extensional province and earthquake hazards at the southern end of the San Andreas Fault system. In the central Salton Trough, North American lithosphere appears to have been rifted completely apart. Based primarily on a 1979 seismic refraction project, the 20-22 km thick crust is apparently composed entirely of new crust added by magmatism from below and sedimentation from above. The new data will constrain the style of continental breakup, the role and mode of magmatism, the effects of rapid Colorado River sedimentation upon extension and magmatism, and the partitioning of oblique extension. The southernmost San Andreas Fault is considered at high risk of producing a large damaging earthquake, yet structures of the fault and adjacent basins are poorly constrained. To improve hazard models, SSIP will image the geometry of the San Andreas and Imperial Faults, structure of sedimentary basins in the Salton Trough, and three-dimensional seismic velocity of the crust and uppermost mantle. SSIP and collaborating projects have been funded by several different programs at NSF and the USGS. These projects include seven lines of land refraction and low-fold reflection data, airguns and OBS data in the Salton Sea, coordinated fieldwork for onshore-offshore and 3-D data, and a densely sampled line of broadband stations across the trough. Fieldwork is tentatively scheduled for 2010. Preliminary work in 2009 included calibration shots in the Imperial Valley that quantified strong ground motion and proved lack of harm to agricultural irrigation tile drains from explosive shots. Piggyback and complementary studies are encouraged.

Analysis of Earthquake Source Spectra in Salton Trough

NASA Astrophysics Data System (ADS)

Chen, X.; Shearer, P. M.

2009-12-01

Previous studies of the source spectra of small earthquakes in southern California show that average Brune-type stress drops vary among different regions, with particularly low stress drops observed in the Salton Trough (Shearer et al., 2006). The Salton Trough marks the southern end of the San Andreas Fault and is prone to earthquake swarms, some of which are driven by aseismic creep events (Lohman and McGuire, 2007). In order to learn the stress state and understand the physical mechanisms of swarms and slow slip events, we analyze the source spectra of earthquakes in this region. We obtain Southern California Seismic Network (SCSN) waveforms for earthquakes from 1977 to 2009 archived at the Southern California Earthquake Center (SCEC) data center, which includes over 17,000 events. After resampling the data to a uniform 100 Hz sample rate, we compute spectra for both signal and noise windows for each seismogram, and select traces with a P-wave signal-to-noise ratio greater than 5 between 5 Hz and 15 Hz. Using selected displacement spectra, we isolate the source spectra from station terms and path effects using an empirical Green’s function approach. From the corrected source spectra, we compute corner frequencies and estimate moments and stress drops. Finally we analyze spatial and temporal variations in stress drop in the Salton Trough and compare them with studies of swarms and creep events to assess the evolution of faulting and stress in the region. References: Lohman, R. B., and J. J. McGuire (2007), Earthquake swarms driven by aseismic creep in the Salton Trough, California, J. Geophys. Res., 112, B04405, doi:10.1029/2006JB004596 Shearer, P. M., G. A. Prieto, and E. Hauksson (2006), Comprehensive analysis of earthquake source spectra in southern California, J. Geophys. Res., 111, B06303, doi:10.1029/2005JB003979.

Case study of a tropical-extratropical interaction and associated heat low development during the AMMA SOP 2006 pre-monsoon season

NASA Astrophysics Data System (ADS)

Fink, A. H.; Pohle, S.

2009-04-01

Tropical Extra-tropical Interactions (TEIs) are often observed in association with an upper-level subtropical trough that penetrates into the tropics and, therefore, interacts with the tropical circulation. As a visible sign, a mid- to upper-level cloud band at the eastern flank of the trough and its related Subtropical Jet, named Tropical Plume (TP), is identifiable in infrared satellite imagery. McGuirk et al. (1987) gave a definition of Tropical Plumes and described the cloud bands as a northern hemisphere winter time phenomena. Previous studies identified TPs throughout the year with being rare in the June-mid- September period. Results of convection dynamics influenced/caused by TEIs during a pre-monsoon season event between 19 and 30 May 2006 will be presented. This case is characterized by two different investigation regions affected by TEI: During the first half of the event high precipitation amounts south-east of the cloud band over Burkina Faso, Benin, Togo, and Ivory Coast are observed caused by thermal forcing and dynamical maintenance by trough related good upper-level outflow conditions due to ageostrophic acceleration towards the trough and low inertial stability, or even inertial instability. This presentation is focused on the second half of this TEI event, which is characterized by the development of a pronounced heat low (HL) south-east of the upper-level trough over tropical West Africa, followed by convection south-east of the low pressure centre. A modified form of the pressure tendency equation (PTE) used by Knippertz and Fink (2008) is a diagnostic tool to investigate, which processes cause pressure drop near the Mali-Burkina Faso border by using both, the operational ECMWF Analysis and the AMMA EU re-analysis. The latter contains additionally the diabatic heating tendencies. Therefore, all terms of the PTE were calculated and will be discussed.

Calibration method and apparatus for measuring the concentration of components in a fluid

DOEpatents

Durham, M.D.; Sagan, F.J.; Burkhardt, M.R.

1993-12-21

A calibration method and apparatus for use in measuring the concentrations of components of a fluid is provided. The measurements are determined from the intensity of radiation over a selected range of radiation wavelengths using peak-to-trough calculations. The peak-to-trough calculations are simplified by compensating for radiation absorption by the apparatus. The invention also allows absorption characteristics of an interfering fluid component to be accurately determined and negated thereby facilitating analysis of the fluid. 7 figures.

Survey mirrors and lenses and their required surface accuracy. Volume 2. Concentrator optical performance software (COPS) user's manual. Final report for September 15, 1978-December 1, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-01-01

The mathematical modeling of 11 different concentrating collectors is documented and instructions are given for use of the computer code. The 11 concentrators modeled are: faceted mirror concentration; fixed mirror, two-axis tracking receiver; parabolic trough collector; linear Fresnel; incremental reflector; inflated cylindrical concentrator; CPC-involute reflector with evacuated receiver; CPC-parabolic/involute reflector; V trough collectors, imaging collapsing concentrator; and parabolic dish collector. (MHR)

Extreme waves under Hurricane Ivan.

PubMed

Wang, David W; Mitchell, Douglas A; Teague, William J; Jarosz, Ewa; Hulbert, Mark S

2005-08-05

Hurricane Ivan, a category 4 storm, passed directly over six wave-tide gauges deployed by the Naval Research Laboratory on the outer continental shelf in the northeastern Gulf of Mexico. Waves were observed with significant wave heights reaching 17.9 meters and maximum crest-to-trough individual wave heights of 27.7 meters (91 feet). Analysis suggests that significant wave heights likely surpassed 21 meters (69 feet) and that maximum crest-to-trough individual wave heights exceeded 40 meters (132 feet) near the eyewall.

Energy 101: Concentrating Solar Power

ScienceCinema

None

2018-02-07

From towers to dishes to linear mirrors to troughs, concentrating solar power (CSP) technologies reflect and collect solar heat to generate electricity. A single CSP plant can generate enough power for about 90,000 homes. This video explains what CSP is, how it works, and how systems like parabolic troughs produce renewable power. For more information on the Office of Energy Efficiency and Renewable Energy's CSP research, see the Solar Energy Technology Program's Concentrating Solar Power Web page at http://www1.eere.energy.gov/solar/csp_program.html.

Calibration method and apparatus for measuring the concentration of components in a fluid

DOEpatents

Durham, Michael D.; Sagan, Francis J.; Burkhardt, Mark R.

1993-01-01

A calibration method and apparatus for use in measuring the concentrations of components of a fluid is provided. The measurements are determined from the intensity of radiation over a selected range of radiation wavelengths using peak-to-trough calculations. The peak-to-trough calculations are simplified by compensating for radiation absorption by the apparatus. The invention also allows absorption characteristics of an interfering fluid component to be accurately determined and negated thereby facilitating analysis of the fluid.

On-line monitoring of H2 generation and the HTF degradation in parabolic trough solar thermal power plants: Development of an optical sensor based on an innovative approach

NASA Astrophysics Data System (ADS)

Pagola, Iñigo; Funcia, Ibai; Sánchez, Marcelino; Gil, Javier; González-Vallejo, Victoria; Bedoya, Maxi; Orellana, Guillermo

2017-06-01

The work presented in this paper offers a robust, effective and economically competitive method for online detection and monitoring of the presence of molecular hydrogen in the heat transfer fluids of parabolic trough collector plants. The novel method is based on a specific fluorescent sensor according to the ES2425002 patent ("Method for the detection and quantification of hydrogen in a heat transfer fluid").

Ripples in Tempe Mensa Region

NASA Technical Reports Server (NTRS)

2004-01-01

1 February 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows large windblown ripples (or, some might say, small dunes) in troughs between mesas of the Tempe Mensa region. The ripples are generally perpendicular to the trough walls, indicating that [missing text] the features blew through these canyons. The image is located near 33.5oN, 69.2oW. The picture covers an area 3 km (1.9 mi) wide; sunlight illuminates the scene from the lower left.

Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer

PubMed Central

Greenall, Sameer A.; Bentley, John D.; Pearce, Lesley A.; Scoble, Judith A.; Sparrow, Lindsay G.; Bartone, Nicola A.; Xiao, Xiaowen; Baxter, Robert C.; Cosgrove, Leah J.; Adams, Timothy E.

2013-01-01

Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I. Its expression in humans is tightly controlled by maternal imprinting, a genetic restraint that is lost in many cancers, resulting in up-regulation of both mature IGF-II mRNA and protein expression. Additionally, increased expression of several longer isoforms of IGF-II, termed “pro” and “big” IGF-II, has been observed. To date, it is ambiguous as to what role these IGF-II isoforms have in initiating and sustaining tumorigenesis and whether they are bioavailable. We have expressed each individual IGF-II isoform in their proper O-glycosylated format and established that all bind to the IGF-I receptor and both insulin receptors A and B, resulting in their activation and subsequent stimulation of fibroblast proliferation. We also confirmed that all isoforms are able to be sequestered into binary complexes with several IGF-binding proteins (IGFBP-2, IGFBP-3, and IGFBP-5). In contrast to this, ternary complex formation with IGFBP-3 or IGFBP-5 and the auxillary protein, acid labile subunit, was severely diminished. Furthermore, big-IGF-II isoforms bound much more weakly to purified ectodomain of the natural IGF-II scavenging receptor, IGF-IIR. IGF-II isoforms thus possess unique biological properties that may enable them to escape normal sequestration avenues and remain bioavailable in vivo to sustain oncogenic signaling. PMID:23166326

Global Sea Level Rise and its Impact Estimation Model by Beach Mechanics, GDP, and Shoreline Length using Big Data Approach.

NASA Astrophysics Data System (ADS)

Xu, A. A.

2016-12-01

Existing research has shown consistent increase in global sea levels due to warming of the climate; since 1870, average global sea level has risen by about 20 cm. There are processes that scientists and coastal engineers can follow to estimate the erosion and flooding risk impacts for specific locations based on historical data. However, there are no methods available to assess the risk impacts for locations where little research has been conducted. In this study, we introduce a prototype to better predict sea level change and land loss using big data technology. Our approach combines cluster analysis and artificial intelligence to classify and calculate impacts for locations worldwide. Data from 235 locations (89 countries) on sea level change was gathered from NOAA data investigations and other research organizations, including beach profile data, shoreline length data, and GDP data. The rate of sea level rise varies from -18 to 21 mm/yr. We divide the data into 4 groups (Group A: +0 to 9mm, Group B: +10 to +20mm, Group C: -0 to -9mm, and Group D:-10 to -20mm). Our research focuses on types A and B only since both reflect increase on sea level rise. We find the correlation between the sea level rise and factors such as the economic parameter (α), sea level rise height (h), beach breaker wave (Hb), gravitational constant (g), period of wave (T), foreshore slope (i), and sand sizes (D). We conclude the sea level rise impact ($ lost) can be more scientifically and precisely predicted using our model.

Morphodynamics of intertidal bars near a seawall on a macrotidal beach, Wissant Bay, northern France

NASA Astrophysics Data System (ADS)

Sedrati, M.; Anthony, E.

2009-04-01

Several studies on beaches with intertidal bar-trough (ridge-and-runnel) systems in settings with relatively large tidal ranges (> 3 m) have focused on cross-shore bar mobility; however a few recent studies have drawn attention to the potential role of longshore transport induced by a mix of wave-tide and wind-forced longshore currents in the morphodynamics of the bars and troughs. The aim of this paper is to briefly highlight the relationship between wind-forced currents on the shallow intertidal zone and rapid intertidal bar-trough morphological response on a macrotidal beach. Fieldwork was conduced on Wissant beach, Wissant Bay, northern France, from 7 to 23 March, 2006. During the experiment, the beach (oriented NE-SW) exhibited three intertidal bar-trough systems and the upper bar was directly attached to a seawall. Seven digital elevation models (DEMs) were generated from high-resolution topographic surveys. Hydrodynamic measurements were obtained from five currentmeters (2 S4 and 3 ADCP) deployed on the bars crests and on the upper beach trough. Wave characteristics were obtained from the measured time series by spectral analysis using Fast Fourier Transforms. Wind speed and direction on the beach were measured using a portable weather station. The mean wind speed and directions averaged every three hours highlight closely-spaced high-energy events during the experiment, with long phases of significant lateral wind stress (NE to ENE). The measured waves and currents showed rapid and strong response to both the changes in wind speed and direction. Longshore currents measured during the experiment on the upper intertidal bar-trough system showed a clear SW flow pattern in response to NE to ENE wind approach directions while the currents in the lower intertidal zone flowed northeastward during the flood, following the coastline, and southwestward during the ebb in response to the tidal current modulation. Strong longshore migration of the upper intertidal bar to the SW was observed during the course of this fieldwork. This longshore migration was attended by erosion of the upper beach in the northeast and accretion in the southwest. Bars in the lower intertidal zone were relatively stable. The SW migration process of the upper intertidal bar during the experiment occurred at rates that fluctuated with the intensity of the longshore current. The net beach volume over the experiment was quite stable, thus showing that morphological change, notably bar migration, simply reflected adjustments to hydrodynamic forcing without new sand inputs into the system. The findings of the present study suggest that cross-shore currents are subordinate to, and may even be mitigated by, wind-forced longshore flows on this beach. The importance of longshore transport on the upper beach is due to hydrodynamic forcing over the shallow depth, with the seawall playing a probable additional longshore canalization effect. Longshore transport should be considered as an essential element of the morphodynamics of bar-trough beaches subject to large tidal ranges and significant lateral wind stress.

Tracing subducted sediment inputs to the Ryukyu arc-Okinawa Trough system: Evidence from thallium isotopes

NASA Astrophysics Data System (ADS)

Shu, Yunchao; Nielsen, Sune G.; Zeng, Zhigang; Shinjo, Ryuichi; Blusztajn, Jerzy; Wang, Xiaoyuan; Chen, Shuai

2017-11-01

Sediments are actively subducted in virtually every arc worldwide. However, quantifying their contributions to arc lavas and thereby establishing budgets of how sediments participate in slab-mantle interaction is challenging. In this contribution we use thallium (Tl) abundances and isotopic compositions of lavas from the Ryukyu arc (including south Kyushu) and its back-arc basin, Okinawa Trough, to investigate the influence of sediments from arc to back-arc. We also present extensive geochemical data for sediments and altered oceanic crust (AOC) outboard of the northern (DSDP Sites 296, 442B, 443 and 444) and central (DSDP Sites 294 and 295) part of the Ryukyu arc. The Tl isotopic compositions of sediments change systematically from lighter outboard of northern Ryukyu arc to heavier outboard of central Ryukyu arc. The feature reflects the dominance of terrigenous material and pelagic sedimentation outboard of the northern and central Ryukyu arc, respectively. Central and northern sections of Ryukyu arc and Okinawa Trough display larger range of Tl isotopic variation than southern section, which is consistent with more pelagic provenance for sediments outboard of central and northern Ryukyu arcs than that of expected sediments outboard of southern Ryukyu arc. Identical Tl, Sr, Nd and Pb isotope variations are found when comparing arc and back arc lavas, which indicates that sediments fluxes also account for the Tl isotopic variations in the Okinawa Trough lavas. Two-end-member mixing models of Tl with Pb, Sr and Nd isotopes require sediment inputs of< 1%, 0.1-1% and 0.3-2% by weight to the depleted mantle source to account for all these isotopic compositions of lavas from northern, central and southern portion of the Ryukyu arc and Okinawa Trough. Bulk mixing between mantle and sediment end members predict very similar sediment fluxes when using Tl, Sr, Nd and Pb isotopes, which indicates that fractionation of these elements must have happened after mixing between mantle and sediments. This conclusion is corroborated by model calculations of mixing between sediment melts with fractionated Sr/Nd ratios and mantle wedge, which show that no arc lava plot on such mixing lines. Thus bulk sediment mixing, rather than sediment melt, is required for the generation of the lavas from the Ryukyu arc and Okinawa Trough. The requirement of bulk sediment mixing occurring before trace element fractionation in the sub-arc mantle is consistent with models where mélange layers form at the top of the slab and are the principle source material for arc lavas. In addition, the fact that sediment components observed in the Ryukyu arc and Okinawa Trough lavas are similar, suggests that transport of mélange material to the source regions of the arc and back arc is equally efficient. This feature is most readily explained if mélange material is transported from the slab as diapirs.

Mutagenicity of furan in female Big Blue B6C3F1 mice

PubMed Central

Terrell, Ashley N.; Huynh, Mailee; Grill, Alex E.; Kovi, Ramesh C.; O’Sullivan, M. Gerard; Guttenplan, Joseph B.; Ho, Yen-Yi; Peterson, Lisa A.

2014-01-01

Furan is an abundant food and environmental contaminant that is a potent liver carcinogen in rodent models. To determine if furan is genotoxic in vivo, female B6C3F1 Big Blue transgenic mice were treated with 15 mg/kg bw furan by gavage 5 days a week for 6 weeks, or once weekly for 3 weeks. Liver cII trans-gene mutation-frequency and mutation spectra were determined. Furan did not increase the mutation frequency under either treatment condition. In the 6-week treatment regimen, there was a change in the cII transgene mutation-spectrum, with the fraction of GC to AT transitions significantly reduced. The only other significant change was an increase in GC to CG transversions; these represented a minor contribution to the overall mutation spectrum. A much larger furan-dependent shift was observed in the 3-week study. There was a significant increase in transversion mutations, predominantly GC to TA transversions as well as smaller non-significant changes in GC to CG and AT to TA transversions. To determine if these mutations were caused by cis-2-butene-1,4-dial (BDA), a reactive metabolite of furan, the mutagenic activity and the mutation spectrum of BDA was determined in vitro, in Big Blue mouse embryonic fibroblasts. This compound did not increase the cII gene mutation-frequency but caused a substantial increase in AT to CG transversions. This increase, however, lost statistical significance when adjusted for multiple comparisons. Together, these findings suggest that BDA may not be directly responsible for the in-vivo effects of furan on mutational spectra. Histopathological analysis of livers from furan-treated mice revealed that furan induced multifocal, hepatocellular necrosis admixed with reactive leukocytes and pigment-laden Kupffer cells, enhanced oval-cell hyperplasia, and increased hepatocyte mitoses, some of which were atypical. An indirect mechanism of genotoxicity is proposed in which chronic toxicity followed by inflammation and secondary cell proliferation triggers cancer development in furan-exposed rodents. PMID:25344163

Distribution and mobility of selenium and other trace elements in shallow groundwater of the western San Joaquin Valley, California

USGS Publications Warehouse

Deverel, S.J.; Milliard, S.P.

1988-01-01

Samples of shallow groundwater that underlies much of the irrigated area in the western San Joaquin Valley, CA, were analyzed for various major ions and trace elements, including selenium. Concentrations of the major ions generally were similar for groundwater collected in the two primary geologic zones - the alluvial fan and basin trough. Selenium concentrations are significantly (α = 0.05) higher in the groundwater of the alluvial-fan zone than in that of the basin-trough zone. The concentrations of oxyanion trace elements were significantly correlated (α = 0.05) with groundwater salinity, but the correlations between selenium and salinity and between molybdenum and salinity were significantly different (α = 0.05) in the alluvial-fan geologic zone compared with those in the basin-trough geologic zone. The evidence suggests that the main factors affecting selenium concentrations in the shallow groundwater are the degree of groundwater salinity and the geologic source of the alluvial soil material.

Origin of giant Martian polygons

NASA Technical Reports Server (NTRS)

Mcgill, George E.; Hills, L. S.

1992-01-01

Extensive areas of the Martian northern plains in Utopia and Acidalia planitiae are characterized by 'polygonal terrane'. Polygonal terrane consists of material cut by complex troughs defining a pattern resembling mudcracks, columnar joints, or frost-wedge polygons on earth. However, the Martian polygons are orders of magnitude larger than these potential earth analogues, leading to severe mechanical difficulties for genetic models based on simple analogy arguments. Plate-bending and finite element models indicate that shrinkage of desiccating sediment or cooling volcanics accompanied by differential compaction over buried topography can account for the stresses responsible for polygon troughs as well as the large size of the polygons. Although trough widths and depths relate primarily to shrinkage, the large scale of the polygonl pattern relates to the spacing between topographic elevations on the surface buried beneath polygonal terrane material. Geological relationships favor a sedimentary origin for polygonal terrane material, but our model is not dependent on the specific genesis. Our analysis also suggests that the polygons must have formed at a geologically rapid rate.

Performance and Simulation of a Stand-alone Parabolic Trough Solar Thermal Power Plant

NASA Astrophysics Data System (ADS)

Mohammad, S. T.; Al-Kayiem, H. H.; Assadi, M. K.; Gilani, S. I. U. H.; Khlief, A. K.

2018-05-01

In this paper, a Simulink® Thermolib Model has been established for simulation performance evaluation of Stand-alone Parabolic Trough Solar Thermal Power Plant in Universiti Teknologi PETRONAS, Malaysia. This paper proposes a design of 1.2 kW parabolic trough power plant. The model is capable to predict temperatures at any system outlet in the plant, as well as the power output produced. The conditions that are taken into account as input to the model are: local solar radiation and ambient temperatures, which have been measured during the year. Other parameters that have been input to the model are the collector’s sizes, location in terms of latitude and altitude. Lastly, the results are presented in graphical manner to describe the analysed variations of various outputs of the solar fields obtained, and help to predict the performance of the plant. The developed model allows an initial evaluation of the viability and technical feasibility of any similar solar thermal power plant.

E and F region study of the evening sector auroral oval - A Chatanika/Dynamics Explorer 2/NOAA 6 comparison

NASA Technical Reports Server (NTRS)

Senior, C.; Sharber, J. R.; Winningham, J. D.; De La Beaujardiere, O.; Heelis, R. A.; Evans, D. S.; Sugiura, M.; Hoegy, W. R.

1987-01-01

Simultaneous data from the Chatanika radar and the DE 2 and NOAA 6 satellites are used to study the typical behavior of the winter evening-sector auroral plasma during moderate and steady magnetic activity. The equatorward edge of the auroral E layer, of the region 2 field-aligned currents, and of the region of intense convection are colocated. The auroral E layer extends several degrees south of the equatorward edge of the keV electron precipitation from the CPS. Although the main trough and ionization channel are embedded in a region of intense electric field where the plasma flows sunward at high speed, the flux tubes associated with these two features have different time histories. The midlatitude trough is located south of the region of electron precipitation, above a proton aurora. The ionization channel marks the poleward edge of the main trough and is colocated with the equatorward boundary of the electron precipitation from the central plasma sheet.

The Edge

NASA Technical Reports Server (NTRS)

2006-01-01

6 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the edge (running diagonally from the lower left to the upper right) of a trough, which is part of a large pit crater complex in Noachis Terra. This type of trough forms through the collapse of surface materials into the subsurface, and often begins as a series of individual pit craters. Over time, continued collapse increases the diameter of individual pits until finally, adjacent pits merge to form a trough such as the one captured in this image. The deep shadowed area is caused in part by an overhang; layered rock beneath this overhang is less resistant to erosion, and thus has retreated tens of meters backward, beneath the overhang. A person could walk up inside this 'cave' formed by the overhanging layered material.

Location near: 47.0oS, 355.7oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

Palynostratigraphy of the Upper Cretaceous and Paleogene Deposits in the South of Western Siberia by Example of Russkaya Polyana Boreholes, Omsk Trough

NASA Astrophysics Data System (ADS)

Lebedeva, N. K.; Kuz'mina, O. B.

2018-01-01

The detailed study of Boreholes 8, 10, and 2 in the Russkaya Polyana district (Omsk Trough) made it possible to reveal the complex structure of the Upper Cretaceous sediments formed in unstable conditions of the marginal part of the Western Siberian basin. The Pokur, Kuznetsovo, Ipatovo, Slavgorod, and Gan'kino formations were subjected to palynological analysis and substantiation of their Late Cretaceous age. Eight biostratigraphic units with dinocysts and five units with spores and pollen from the Albian to the Maastrichtian were identified. The joint application of biostratigraphic and magnetostratigraphic methods made it possible to reveal the stratigraphic breaks in the studied sedimentary stratum and to estimate their scope. The age of the Lower Lyulinvor Subformation was specified in the marginal part of the Omsk Trough. The ingression traces of the Western Siberian basin in the Albian were found for the first time in the considered region.

Solar photochemical process engineering for production of fuels and chemicals

NASA Technical Reports Server (NTRS)

Biddle, J. R.; Peterson, D. B.; Fujita, T.

1984-01-01

The engineering costs and performance of a nominal 25,000 scmd (883,000 scfd) photochemical plant to produce dihydrogen from water were studied. Two systems were considered, one based on flat-plate collector/reactors and the other on linear parabolic troughs. Engineering subsystems were specified including the collector/reactor, support hardware, field transport piping, gas compression equipment, and balance-of-plant (BOP) items. Overall plant efficiencies of 10.3 and 11.6% are estimated for the flat-plate and trough systems, respectively, based on assumed solar photochemical efficiencies of 12.9 and 14.6%. Because of the opposing effects of concentration ratio and operating temperature on efficiency, it was concluded that reactor cooling would be necessary with the trough system. Both active and passive cooling methods were considered. Capital costs and energy costs, for both concentrating and non-concentrating systems, were determined and their sensitivity to efficiency and economic parameters were analyzed. The overall plant efficiency is the single most important factor in determining the cost of the fuel.

Solar photochemical process engineering for production of fuels and chemicals

NASA Technical Reports Server (NTRS)

Biddle, J. R.; Peterson, D. B.; Fujita, T.

1985-01-01

The engineering costs and performance of a nominal 25,000 scmd (883,000 scfd) photochemical plant to produce dihydrogen from water were studied. Two systems were considered, one based on flat-plate collector/reactors and the other on linear parabolic troughs. Engineering subsystems were specified including the collector/reactor, support hardware, field transport piping, gas compression equipment, and balance-of-plant (BOP) items. Overall plant efficiencies of 10.3 and 11.6 percent are estimated for the flat-plate and trough systems, respectively, based on assumed solar photochemical efficiencies of 12.9 and 14.6 percent. Because of the opposing effects of concentration ratio and operating temperature on efficiency, it was concluded that reactor cooling would be necessary with the trough system. Both active and passive cooling methods were considered. Capital costs and energy costs, for both concentrating and non-concentrating systems, were determined and their sensitivity to efficiency and economic parameters were analyzed. The overall plant efficiency is the single most important factor in determining the cost of the fuel.

Harmonization of standards for parabolic trough collector testing in solar thermal power plants

NASA Astrophysics Data System (ADS)

Sallaberry, Fabienne; Valenzuela, Loreto; Palacin, Luis G.; Leon, Javier; Fischer, Stephan; Bohren, Andreas

2017-06-01

The technology of parabolic trough collectors (PTC) is used widely in concentrating Solar Power (CSP) plants worldwide. However this type of large-size collectors cannot be officially tested by an accredited laboratory and certified by an accredited certification body so far, as there is no standard adapted to its particularity, and the current published standard for solar thermal collectors are not completely applicable to them. Recently some standardization committees have been working on this technology. This paper aims to give a summary of the standardized testing methodology of large-size PTC for CSP plants, giving the physical model chosen for modeling the thermal performance of the collector in the new revision of standard ISO 9806 and the points still to be improved in the standard draft IEC 62862-3-2. In this paper, a summary of the testing validation performed on one parabolic trough collector installed in one of the test facilities at the Plataforma Solar de Almería (PSA) with this new model is also presented.

Permanently enhanced dynamic triggering probabilities as evidenced by two M ≥ 7.5 earthquakes

USGS Publications Warehouse

Gomberg, Joan S.

2013-01-01

The 2012 M7.7 Haida Gwaii earthquake radiated waves that likely dynamically triggered the 2013M7.5 Craig earthquake, setting two precedents. First, the triggered earthquake is the largest dynamically triggered shear failure event documented to date. Second, the events highlight a connection between geologic structure, sedimentary troughs that act as waveguides, and triggering probability. The Haida Gwaii earthquake excited extraordinarily large waves within and beyond the Queen Charlotte Trough, which propagated well into mainland Alaska and likely triggering the Craig earthquake along the way. Previously, focusing and associated dynamic triggering have been attributed to unpredictable source effects. This case suggests that elevated dynamic triggering probabilities may exist along the many structures where sedimentary troughs overlie major faults, such as subduction zones’ accretionary prisms and transform faults’ axial valleys. Although data are sparse, I find no evidence of accelerating seismic activity in the vicinity of the Craig rupture between it and the Haida Gwaii earthquake.

Friction stir welding process to repair voids in aluminum alloys

NASA Technical Reports Server (NTRS)

Rosen, Charles D. (Inventor); Litwinski, Edward (Inventor); Valdez, Juan M. (Inventor)

1999-01-01

The present invention provides an in-process method to repair voids in an aluminum alloy, particularly a friction stir weld in an aluminum alloy. For repairing a circular void or an in-process exit hole in a weld, the method includes the steps of fabricating filler material of the same composition or compatible with the parent material into a plug form to be fitted into the void, positioning the plug in the void, and friction stir welding over and through the plug. For repairing a longitudinal void (30), the method includes machining the void area to provide a trough (34) that subsumes the void, fabricating filler metal into a strip form (36) to be fitted into the trough, positioning the strip in the trough, and rewelding the void area by traversing a friction stir welding tool longitudinally through the strip. The method is also applicable for repairing welds made by a fusing welding process or voids in aluminum alloy workpieces themselves.

Back-Arc Opening in the Western End of the Okinawa Trough Revealed From GNSS/Acoustic Measurements

NASA Astrophysics Data System (ADS)

Chen, Horng-Yue; Ikuta, Ryoya; Lin, Cheng-Horng; Hsu, Ya-Ju; Kohmi, Takeru; Wang, Chau-Chang; Yu, Shui-Beih; Tu, Yoko; Tsujii, Toshiaki; Ando, Masataka

2018-01-01

We measured seafloor movement using a Global Navigation Satellite Systems (GNSS)/Acoustic technique at the south of the rifting valley in the western end of the Okinawa Trough back-arc basin, 60 km east of northeastern corner of Taiwan. The horizontal position of the seafloor benchmark, measured eight times between July 2012 and May 2016, showed a southeastward movement suggesting a back-arc opening of the Okinawa Trough. The average velocity of the seafloor benchmark shows a block motion together with Yonaguni Island. The westernmost part of the Ryukyu Arc rotates clockwise and is pulled apart from the Taiwan Island, which should cause the expansion of the Yilan Plain, Taiwan. Comparing the motion of the seafloor benchmark with adjacent seismicity, we suggest a gentle episodic opening of the rifting valley accompanying a moderate seismic activation, which differs from the case in the segment north off-Yonaguni Island where a rapid dyke intrusion occurs with a significant seismic activity.

An innovative index for evaluating water quality in streams.

PubMed

Said, Ahmend; Stevens, David K; Sehlke, Gerald

2004-09-01

A water quality index expressed as a single number is developed to describe overall water quality conditions using multiple water quality variables. The index consists of water quality variables: dissolved oxygen, specific conductivity, turbidity, total phosphorus, and fecal coliform. The objectives of this study were to describe the preexisting indices and to define a new water quality index that has advantages over these indices. The new index was applied to the Big Lost River Watershed in Idaho, and the results gave a quantitative picture for the water quality situation. If the new water quality index for the impaired water is less than a certain number, remediation-likely in the form of total maximum daily loads or changing the management practices-may be needed. The index can be used to assess water quality for general beneficial uses. Nevertheless, the index cannot be used in making regulatory decisions, indicate water quality for specific beneficial uses, or indicate contamination from trace metals, organic contaminants, and toxic substances.

Floods of December 1961 in Mississippi and adjoining states

USGS Publications Warehouse

Shell, James D.

1962-01-01

Widespread floods occurred over parts of Mississippi, Louisiana, and Alabama after heavy rains during December 18, 1961. A series of low-pressure systems produced as much as 19 inches of rainfall in some areas. Heavy rainfall, 7 to 11 inches, on December 10 resulted in outstanding floods on small streams in southern Mississippi and southwestern Alabama. Subsequent rains produced multiple floods on small streams and outstanding floods of prolonged duration along the Big Black, upper Pearl, and lower Tombigbee Rivers in Mississippi. At Jackson, Miss., the Pearl River reached the highest stage known. Along the east bank, flood waters topped or breached some of the levee system protecting the Flowood industrial area, but other parts were saved by extensive reinforcement and by emergency operation of the partially completed dam 10 miles upstream. Additional heavy damage to commercial and industrial property was prevented as a result of these measures. Elsewhere, damage was restricted primarily to secondary highways and bridges. Two lives were lost.

GC/MS and proteomics to unravel the painting history of the lost Giant Buddhas of Bāmiyān (Afghanistan)

PubMed Central

Galano, Eugenio; Blaensdorf, Catharina; Emmerling, Erwin; Perla Colombini, Maria; Birolo, Leila

2017-01-01

A chemical investigation of the organic paint binders of the Giant Buddhas of Bāmiyān was performed using an analytical approach based on mass spectrometry, combining traditional gas chromatography/mass spectrometry protocols with advanced proteomics methodologies. The research was carried out on a selection of rescued fragments. The data revealed the use of egg proteins as the paint binders of the original layers, in accordance with the traditional use of this proteinaceous medium in antiquity, spanning from the Mediterranean basin to the Far East, and already in the Bronze Age. Egg tempera was thus known to artists of the region in the first centuries AD, probably also due to the position of the Bāmiyān valley, which was connected to the Silk Road. Milk was found in the first historical overpaintings. A new proteomics approach was used, which was able to identify the source of the milk proteins present in the restoration layers, despite their age and degradation. In particular cow’s and goat's milk were both found, in agreement with the documented presence of rich pastures in the Bāmiyān valley when the historical restorations were carried out. Investigating the materials of the Giant Buddhas not only enabled us to obtain isolated data on these invaluable works of art, which are now lost, but contributes to understanding the big “puzzle” of our past and the development of our culture, by implementing and supporting written sources, stylistic and anthropological studies with molecular data. PMID:28379960

GC/MS and proteomics to unravel the painting history of the lost Giant Buddhas of Bāmiyān (Afghanistan).

PubMed

Lluveras-Tenorio, Anna; Vinciguerra, Roberto; Galano, Eugenio; Blaensdorf, Catharina; Emmerling, Erwin; Perla Colombini, Maria; Birolo, Leila; Bonaduce, Ilaria

2017-01-01

A chemical investigation of the organic paint binders of the Giant Buddhas of Bāmiyān was performed using an analytical approach based on mass spectrometry, combining traditional gas chromatography/mass spectrometry protocols with advanced proteomics methodologies. The research was carried out on a selection of rescued fragments. The data revealed the use of egg proteins as the paint binders of the original layers, in accordance with the traditional use of this proteinaceous medium in antiquity, spanning from the Mediterranean basin to the Far East, and already in the Bronze Age. Egg tempera was thus known to artists of the region in the first centuries AD, probably also due to the position of the Bāmiyān valley, which was connected to the Silk Road. Milk was found in the first historical overpaintings. A new proteomics approach was used, which was able to identify the source of the milk proteins present in the restoration layers, despite their age and degradation. In particular cow's and goat's milk were both found, in agreement with the documented presence of rich pastures in the Bāmiyān valley when the historical restorations were carried out. Investigating the materials of the Giant Buddhas not only enabled us to obtain isolated data on these invaluable works of art, which are now lost, but contributes to understanding the big "puzzle" of our past and the development of our culture, by implementing and supporting written sources, stylistic and anthropological studies with molecular data.

Formation of Continental Fragments: The Tamayo Bank, Gulf of California

NASA Astrophysics Data System (ADS)

van Wijk, J.; Abera, R.; Axen, G. J.

2015-12-01

Potential field data are used to construct a two-dimensional crustal model along a profile through the Tamayo Trough and Bank in the Gulf of California. The model is constrained by seismic reflection and refraction data, and field observations. The potential field data do not fit a model where the crust of the Tamayo trough is continental, but they fit well with a model where the Tamayo trough crust is oceanic. This implies that the Tamayo Bank is entirely bounded by oceanic crust and is a microcontinent. The oceanic crust of the Tamayo trough that separates the Tamayo Bank from the mainland of Mexico is thin (~4 km), so oceanic spreading was probably magma-starved before it ceased. This led us to come up with a model that explains the formation of microcontinents that are smaller in size and are not found in the proximity of hotspots. At first, seafloor spreading commences following continental breakup. When the magma supply to the ridge slows down, the plate boundary strengthens. Hence, the ridge may be abandoned while tectonic extension begins elsewhere, or slow spreading may continue while a new ridge starts to develop. The old spreading ridge becomes extinct. An asymmetric ocean basin forms if the ridge jumps within oceanic lithosphere; a microcontinent forms if the ridge jumps into a continental margin. This model for formation of continental fragments is applicable to other regions as well, eliminating the need of mantle plume impingement to facilitate rifting of a young continental margin and microcontinent formation.

Comparative Tectonics of Europa and Ganymede

NASA Astrophysics Data System (ADS)

Pappalardo, R. T.; Collins, G. C.; Prockter, L. M.; Head, J. W.

2000-10-01

Europa and Ganymede are sibling satellites with tectonic similarities and differences. Ganymede's ancient dark terrain is crossed by furrows, probably related to ancient large impacts, and has been normal faulted to various degrees. Bright grooved is pervasively deformed at multiple scales and is locally highly strained, consistent with normal faulting of an ice-rich lithosphere above a ductile asthenosphere, along with minor horizontal shear. Little evidence has been identified for compressional structures. The relative roles of tectonism and icy cryovolcanism in creating bright grooved terrain is an outstanding issue. Some ridge and trough structures within Europa's bands show tectonic similarities to Ganymede's grooved terrain, specifically sawtooth structures resembling normal fault blocks. Small-scale troughs are consistent with widened tension fractures. Shearing has produced transtensional and transpressional structures in Europan bands. Large-scale folds are recognized on Europa, with synclinal small-scale ridges and scarps probably representing folds and/or thrust blocks. Europa's ubiquitous double ridges may have originated as warm ice upwelled along tidally heated fracture zones. The morphological variety of ridges and troughs on Europa imply that care must be taken in inferring their origin. The relative youth of Europa's surface means that the satellite has preserved near-pristine morphologies of many structures, though sputter erosion could have altered the morphology of older topography. Moderate-resolution imaging has revealed lesser apparent diversity in Ganymede's ridge and trough types. Galileo's 28th orbit has brought new 20 m/pixel imaging of Ganymede, allowing direct comparison to Europa's small-scale structures.

Environments of Long-Lived Mesoscale Convective Systems Over the Central United States in Convection Permitting Climate Simulations

NASA Astrophysics Data System (ADS)

Yang, Qing; Houze, Robert A.; Leung, L. Ruby; Feng, Zhe

2017-12-01

Continental-scale convection-permitting simulations of the warm seasons of 2011 and 2012 using the Weather Research and Forecasting model reproduce realistic structure and frequency distribution of lifetime and event mean precipitation of mesoscale convective systems (MCSs) over the central United States. Analysis is performed to determine the environmental conditions conducive to generating long-lived MCSs. The simulations show that MCSs systematically form over the central Great Plains ahead of a trough in the westerlies in combination with an enhanced low-level moist jet from the Gulf of Mexico. These environmental properties at the time of storm initiation are most prominent for the MCSs that persist for the longest times. MCSs reaching lifetimes of 9 h or more occur closer to the approaching trough than shorter-lived MCSs. These long-lived MCSs exhibit the strongest feedback to the environment through diabatic heating in the trailing regions of the MCSs. The feedback strengthens the synoptic-scale trough associated with the MCS by producing an anomaly circulation characterized by a divergent perturbation at high levels over the MCS and a midlevel cyclonic circulation perturbation near the trough line in association with the trailing portion of the MCS. The quasi-balanced mesoscale vortex may help to maintain the MCS over a long period of time by feeding dry, cool air into the environment at the rear of the MCS region that enhances evaporative cooling and helps maintain the MCS.

The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors.

PubMed

Scheer, Frank A J L; Morris, Christopher J; Shea, Steven A

2013-03-01

Despite the extended overnight fast, paradoxically, people are typically not ravenous in the morning and breakfast is typically the smallest meal of the day. We assessed whether this paradox could be explained by an endogenous circadian influence on appetite with a morning trough, while controlling for sleep/wake and fasting/feeding effects. Twelve healthy non-obese adults (six males; age, 20-42 years) were studied throughout a 13-day laboratory protocol that balanced all behaviors, including eucaloric meals and sleep periods, evenly across the endogenous circadian cycle. Participants rated their appetite and food preferences by visual analog scales. There was a large endogenous circadian rhythm in hunger, with the trough in the biological morning (8 AM) and peak in the biological evening (8 PM; peak-to-trough amplitude = 17%; P = 0.004). Similarly-phased significant endogenous circadian rhythms were present in appetites for sweet, salty and starchy foods, fruits, meats/poultry, food overall, and for estimates of how much food participants could eat (amplitudes 14-25%; all P < 0.05). In people who sleep at night, the intrinsic circadian evening peak in appetite may promote larger meals before the fasting period necessitated by sleep, whereas the circadian morning trough would theoretically facilitate the extended overnight fast. Furthermore, the circadian decline in hunger across the night would theoretically counteract the fasting-induced hunger increase that could otherwise disrupt sleep. Copyright © 2013 The Obesity Society.

Exploring fungal diversity in deep-sea sediments from Okinawa Trough using high-throughput Illumina sequencing

NASA Astrophysics Data System (ADS)

Zhang, Xiao-Yong; Wang, Guang-Hua; Xu, Xin-Ya; Nong, Xu-Hua; Wang, Jie; Amin, Muhammad; Qi, Shu-Hua

2016-10-01

The present study investigated the fungal diversity in four different deep-sea sediments from Okinawa Trough using high-throughput Illumina sequencing of the nuclear ribosomal internal transcribed spacer-1 (ITS1). A total of 40,297 fungal ITS1 sequences clustered into 420 operational taxonomic units (OTUs) with 97% sequence similarity and 170 taxa were recovered from these sediments. Most ITS1 sequences (78%) belonged to the phylum Ascomycota, followed by Basidiomycota (17.3%), Zygomycota (1.5%) and Chytridiomycota (0.8%), and a small proportion (2.4%) belonged to unassigned fungal phyla. Compared with previous studies on fungal diversity of sediments from deep-sea environments by culture-dependent approach and clone library analysis, the present result suggested that Illumina sequencing had been dramatically accelerating the discovery of fungal community of deep-sea sediments. Furthermore, our results revealed that Sordariomycetes was the most diverse and abundant fungal class in this study, challenging the traditional view that the diversity of Sordariomycetes phylotypes was low in the deep-sea environments. In addition, more than 12 taxa accounted for 21.5% sequences were found to be rarely reported as deep-sea fungi, suggesting the deep-sea sediments from Okinawa Trough harbored a plethora of different fungal communities compared with other deep-sea environments. To our knowledge, this study is the first exploration of the fungal diversity in deep-sea sediments from Okinawa Trough using high-throughput Illumina sequencing.

Dynamical analysis of extreme precipitation in the US northeast based on large-scale meteorological patterns

NASA Astrophysics Data System (ADS)

Agel, Laurie; Barlow, Mathew; Colby, Frank; Binder, Hanin; Catto, Jennifer L.; Hoell, Andrew; Cohen, Judah

2018-05-01

Previous work has identified six large-scale meteorological patterns (LSMPs) of dynamic tropopause height associated with extreme precipitation over the Northeast US, with extreme precipitation defined as the top 1% of daily station precipitation. Here, we examine the three-dimensional structure of the tropopause LSMPs in terms of circulation and factors relevant to precipitation, including moisture, stability, and synoptic mechanisms associated with lifting. Within each pattern, the link between the different factors and extreme precipitation is further investigated by comparing the relative strength of the factors between days with and without the occurrence of extreme precipitation. The six tropopause LSMPs include two ridge patterns, two eastern US troughs, and two troughs centered over the Ohio Valley, with a strong seasonality associated with each pattern. Extreme precipitation in the ridge patterns is associated with both convective mechanisms (instability combined with moisture transport from the Great Lakes and Western Atlantic) and synoptic forcing related to Great Lakes storm tracks and embedded shortwaves. Extreme precipitation associated with eastern US troughs involves intense southerly moisture transport and strong quasi-geostrophic forcing of vertical velocity. Ohio Valley troughs are associated with warm fronts and intense warm conveyor belts that deliver large amounts of moisture ahead of storms, but little direct quasi-geostrophic forcing. Factors that show the largest difference between days with and without extreme precipitation include integrated moisture transport, low-level moisture convergence, warm conveyor belts, and quasi-geostrophic forcing, with the relative importance varying between patterns.

Poisson regression models outperform the geometrical model in estimating the peak-to-trough ratio of seasonal variation: a simulation study.

PubMed

Christensen, A L; Lundbye-Christensen, S; Dethlefsen, C

2011-12-01

Several statistical methods of assessing seasonal variation are available. Brookhart and Rothman [3] proposed a second-order moment-based estimator based on the geometrical model derived by Edwards [1], and reported that this estimator is superior in estimating the peak-to-trough ratio of seasonal variation compared with Edwards' estimator with respect to bias and mean squared error. Alternatively, seasonal variation may be modelled using a Poisson regression model, which provides flexibility in modelling the pattern of seasonal variation and adjustments for covariates. Based on a Monte Carlo simulation study three estimators, one based on the geometrical model, and two based on log-linear Poisson regression models, were evaluated in regards to bias and standard deviation (SD). We evaluated the estimators on data simulated according to schemes varying in seasonal variation and presence of a secular trend. All methods and analyses in this paper are available in the R package Peak2Trough[13]. Applying a Poisson regression model resulted in lower absolute bias and SD for data simulated according to the corresponding model assumptions. Poisson regression models had lower bias and SD for data simulated to deviate from the corresponding model assumptions than the geometrical model. This simulation study encourages the use of Poisson regression models in estimating the peak-to-trough ratio of seasonal variation as opposed to the geometrical model. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Laboratory simulation of hydrothermal petroleum formation from sediment in Escanaba Trough, offshore from northern California

USGS Publications Warehouse

Kvenvolden, K.A.; Rapp, J.B.; Hostettler, F.D.; Rosenbauer, R.J.

1994-01-01

Petroleum associated with sulfide-rich sediment is present in Escanaba Trough at the southern end of the Gorda Ridge spreading axis offshore from northern California within the Exclusive Economic Zone (EEZ) of the U.S. This location and occurrence are important for evaluation of the mineral and energy resource potential of the seafloor under U.S. jurisdiction. In Escanaba Trough, petroleum is believed to be formed by hydrothermal processes acting on mainly terrigenous organic material in Quaternary, river-derived sediment. To attempt to simulate these processes in the laboratory, portions of a Pleistocene gray-green mud, obtained from ??? 1.5 m below the seafloor at a water depth of ??? 3250 m in Escanaba Trough, were heated in the presence of water in four hydrous-pyrolysis experiments conducted at temperatures ranging from 250 to 350??C and at a pressure of 350 bar for 1.0-4.5 days. Distributions of n-alkanes, isoprenoid hydrocarbons, triterpanes, and steranes in the heated samples were compared with those in a sample of hydrothermal petroleum from the same area. Mud samples heated for less than 4.5 days at less than 350??C show changes in some, but not all, molecular marker ratios of organic compounds that are consistent with those expected during hydrothermal petroleum formation. Our results suggest that the organic matter in this type of sediment serves as one possible source for some of the compounds found in the hydrothermal petroleum. ?? 1994.

Geologic Mapping of Vesta

NASA Technical Reports Server (NTRS)

Yingst, R. A.; Mest, S. C.; Berman, D. C.; Garry, W. B.; Williams, D. A.; Buczkowski, D.; Jaumann, R.; Pieters, C. M.; De Sanctis, M. C.; Frigeri, A.;

Seafloor glacial geomorphology in a cross shelf trough: insights into the deglaciation of the Melville Bay Ice Stream

NASA Astrophysics Data System (ADS)

Newton, Andrew; Huuse, Mads

2016-04-01

Compared to other glaciated margins such as offshore mid-Norway and Svalbard, the Greenland continental shelf has, until recently, been the subject of only a limited amount of academic and industry research. This has been mainly due to the difficulty and expense of obtaining data in such harsh and operationally complex settings. Climate amelioration and technological advance has, particularly in recent years, allowed both academics and industry to substantially increase data collection across the many glaciated continental shelves in the Northern Hemisphere. Baffin Bay has been one of the primary regions of interest for the hydrocarbon industry which has sought to operate in the frontier basins offshore Greenland. As a result of these industry operations, a large database of geophysical and geological data has been collected. Some of this data has been made available to glacial scientists and provides a unique opportunity to investigate the seafloor geomorphology for regions where the majority of previous work has been hypothetical rather than grounded in geological evidence. In the work presented here we present a landform record offshore NW Greenland in the Melville Bay cross-shelf trough. This is one of the largest troughs on the entire Greenland shelf and measures up to 140 km in width. Shallow-marine cores collected in the coastal part of the trough show bedrock of Miocene age and indicate that a significant cover has likely been removed from the shelf by ice streams operating through the Late Cenozoic. This material has then been deposited at the shelf edge as a trough mouth fan. Using multibeam and seismic reflection data a large number of glacial landforms are observed and mapped in the trough. These include mega-scale glacial lineations, grounding-zone wedges, iceberg scours, and iceberg grounding pits. These landforms are used to reconstruct the ice dynamics of the Melville Bugt Ice Stream at the last glacial maximum and during its deglaciation. The observed grounding-zone wedges suggest that initial retreat was punctuated with two still-stands of long enough duration to accumulate material at the grounding zone. As the ice sheet decayed further, a rapid retreat of over 30 km occurred before the grounding line margin was stabilised again. Understanding the nonlinear rate of grounding-line retreat such as that presented here is crucial for the future modelling of not just the evolution of the Greenland Ice Sheet but also those elsewhere.

Facies analysis, depositional environments and paleoclimate of the Cretaceous Bima Formation in the Gongola Sub - Basin, Northern Benue Trough, NE Nigeria

NASA Astrophysics Data System (ADS)

Shettima, B.; Abubakar, M. B.; Kuku, A.; Haruna, A. I.

2018-01-01

Facies analysis of the Cretaceous Bima Formation in the Gongola Sub -basin of the Northern Benue Trough northeastern Nigeria indicated that the Lower Bima Member is composed of alluvial fan and braided river facies associations. The alluvial fan depositional environment dominantly consists of debris flow facies that commonly occur as matrix supported conglomerate. This facies is locally associated with grain supported conglomerate and mudstone facies, representing sieve channel and mud flow deposits respectively, and these deposits may account for the proximal alluvial fan region of the Lower Bima Member. The distal fan facies were represented by gravel-bed braided river system of probably Scot - type model. This grade into sandy braided river systems with well developed floodplains facies, forming probably at the lowermost portion of the alluvial fan depositional gradient, where it inter-fingers with basinal facies. In the Middle Bima Member, the facies architecture is dominantly suggestive of deep perennial sand-bed braided river system with thickly developed amalgamated trough crossbedded sandstone facies fining to mudstone. Couplets of shallow channels are also locally common, attesting to the varying topography of the basin. The Upper Bima Member is characterized by shallow perennial sand-bed braided river system composed of successive succession of planar and trough crossbedded sandstone facies associations, and shallower channels of the flashy ephemeral sheetflood sand - bed river systems defined by interbedded succession of small scale trough crossbedded sandstone facies and parallel laminated sandstone facies. The overall stacking pattern of the facies succession of the Bima Formation in the Gongola Sub - basin is generally thinning and fining upwards cycles, indicating scarp retreat and deposition in a relatively passive margin setting. Dominance of kaolinite in the clay mineral fraction of the Bima Formation points to predominance of humid sub - tropical to tropical climatic conditions. This favors pedogenic activities which are manifested in the several occurrences of paleosols. Pronounced periods of arid climatic conditions are also notable from the subordinate smectite mineralization. Chlorite mineralization at some localities is indicative of elevation of the provenance area, and this is synonymous with deposition of the Bima Formation, because of its syn - depositional tectonics. The absences of lacustrine shales in the syn - rift stratigraphic architecture of the Bima Formation indicates that the lower Cretaceous petroleum system that are common in the West and Central African Rift basins are generally barren in the Gongola Sub - basin of the Northern Benue Trough.

Shielded serpentine traveling wave tube deflection structure

DOEpatents

Hudson, Charles L.; Spector, Jerome

1994-01-01

A shielded serpentine slow wave deflection structure (10) having a serpene signal conductor (12) within a channel groove (46). The channel groove (46) is formed by a serpentine channel (20) in a trough plate (18) and a ground plane (14). The serpentine signal conductor (12) is supported at its ends by coaxial feed through connectors 28. A beam interaction trough (22) intersects the channel groove (46) to form a plurality of beam interaction regions (56) wherein an electron beam (54) may be deflected relative to the serpentine signal conductor (12).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binotti, M.; Zhu, G.; Gray, A.

An analytical approach, as an extension of one newly developed method -- First-principle OPTical Intercept Calculation (FirstOPTIC) -- is proposed to treat the geometrical impact of three-dimensional (3-D) effects on parabolic trough optical performance. The mathematical steps of this analytical approach are presented and implemented numerically as part of the suite of FirstOPTIC code. In addition, the new code has been carefully validated against ray-tracing simulation results and available numerical solutions. This new analytical approach to treating 3-D effects will facilitate further understanding and analysis of the optical performance of trough collectors as a function of incidence angle.

1/32 Degree Real-Time Global Ocean Prediction and Value-Added Over 1/16 Degree Resolution

DTIC Science & Technology

2007-07-30

SSH ridge to the south of these eddies are captured by at least one of the two data narrowing the trough, both assisting in cutting off eddy...In Section 3.4, the off from a GFO track a week later (Fig. 3D). Eddy #12 Hawaiian Islands region is used to compare results where was already...Journal of Marine Systems 65 (2007) 3-26 13 The second example is the cluster of 6 small eddies week leading up to 29 Sept. This formed an SSH trough

Nonimaging secondary concentrators for large rim angle parabolic troughs with tubular absorbers.

PubMed

Ries, H; Spirkl, W

1996-05-01

For parabolic trough solar collectors with tubular absorbers, we design new tailored secondary concentrators. The design is applicable for any rim angle of a parabolic reflector. With the secondary, the concentration can be increased by a factor of more than 2 with a compact secondary reflector consisting of a single piece, even for the important case of a rim angle of 90 deg. The parabolic reflector can be used without changes; the reduced absorber is still tubular but smaller than the original absorber and slightly displaced toward the primary.

Flow of a surfactant across a thin liquid film wetting a solid substrate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, J.B.; He, S.X.; Dutta, P.

1989-12-15

Transfer of a monolayer (valinomycin) between two Langmuir troughs via an interconnecting glass bridge'' has been observed when there is a difference between the monolayer pressures in the two troughs. Assuming that the transfer occurs over the surface of the thin film of water that wets the bridge,'' the transfer rate can be used to estimate the thickness of the liquid film. The thickness thus determined may be used to determine the retarded van der Waals (Hamaker) constant associated with the interaction of the film with the underlying substrate.

Climatic Variations in Tropical West African Rainfall and the Implications for Military Planners

DTIC Science & Technology

2008-06-01

perturbation pressure isobars. There is a ridge in (a) and a trough in (b) at the equator and to the east of the forcing region. Note that the pressure...Climatology course project team), CDR Eric Buch (C6F Oceanographer), Mr. Samson Brand (NRL Monterey), VADM Paul Gaffney (ret.), Prof. Russell Elsberry, LT...pressure isobars. There is a ridge in (a) and a trough in (b) at the equator and to the east of the forcing region. Note that the pressure to the west

First Born amplitude for transitions from a circular state to a state of large (l, m)

NASA Astrophysics Data System (ADS)

Dewangan, D. P.

2005-01-01

The use of cylindrical polar coordinates instead of the conventional spherical polar coordinates enables us to derive compact expressions of the first Born amplitude for some selected sets of transitions from an arbitrary initial circular \\big|\\psi_{n_i,n_i-1,n_i-1}\\big\\rangle state to a final \\big|\\psi_{n_f,l_f,m_f}\\big\\rangle state of large (lf, mf). The formulae for \\big|\\psi_{n_i,n_i-1,n_i-1}\\big\\rangle \\longrightarrow \\big|\\psi_{n_f,n_f-1,n_f-2}\\big\\rangle and \\big|\\psi_{n_i,n_i-1,n_i-1}\\big\\rangle \\longrightarrow \\big|\\psi_{n_f,n_f-1,n_f-3}\\big\\rangle transitions are expressed in terms of the Jacobi polynomials which serve as suitable starting points for constructing complete solutions over the bound energy levels of hydrogen-like atoms. The formulae for \\big|\\psi_{n_i,n_i-1,n_i-1}\\big\\rangle \\longrightarrow \\big|\\psi_{n_f,n_f-1,-(n_f-2)}\\big\\rangle and \\big|\\psi_{n_i,n_i-1,n_i-1}\\big\\rangle \\longrightarrow \\big|\\psi_{n_f,n_f-1,-(n_f-3)}\\big\\rangle transitions are in simple algebraic forms and are directly applicable to all possible values of ni and nf. It emerges that the method can be extended to evaluate the first Born amplitude for many other transitions involving states of large (l, m).

Hazard assessment of long-period ground motions for the Nankai Trough earthquakes

NASA Astrophysics Data System (ADS)

Maeda, T.; Morikawa, N.; Aoi, S.; Fujiwara, H.

2013-12-01

We evaluate a seismic hazard for long-period ground motions associated with the Nankai Trough earthquakes (M8~9) in southwest Japan. Large interplate earthquakes occurring around the Nankai Trough have caused serious damages due to strong ground motions and tsunami; most recent events were in 1944 and 1946. Such large interplate earthquake potentially causes damages to high-rise and large-scale structures due to long-period ground motions (e.g., 1985 Michoacan earthquake in Mexico, 2003 Tokachi-oki earthquake in Japan). The long-period ground motions are amplified particularly on basins. Because major cities along the Nankai Trough have developed on alluvial plains, it is therefore important to evaluate long-period ground motions as well as strong motions and tsunami for the anticipated Nankai Trough earthquakes. The long-period ground motions are evaluated by the finite difference method (FDM) using 'characterized source models' and the 3-D underground structure model. The 'characterized source model' refers to a source model including the source parameters necessary for reproducing the strong ground motions. The parameters are determined based on a 'recipe' for predicting strong ground motion (Earthquake Research Committee (ERC), 2009). We construct various source models (~100 scenarios) giving the various case of source parameters such as source region, asperity configuration, and hypocenter location. Each source region is determined by 'the long-term evaluation of earthquakes in the Nankai Trough' published by ERC. The asperity configuration and hypocenter location control the rupture directivity effects. These parameters are important because our preliminary simulations are strongly affected by the rupture directivity. We apply the system called GMS (Ground Motion Simulator) for simulating the seismic wave propagation based on 3-D FDM scheme using discontinuous grids (Aoi and Fujiwara, 1999) to our study. The grid spacing for the shallow region is 200 m and 100 m in horizontal and vertical, respectively. The grid spacing for the deep region is three times coarser. The total number of grid points is about three billion. The 3-D underground structure model used in the FD simulation is the Japan integrated velocity structure model (ERC, 2012). Our simulation is valid for period more than two seconds due to the lowest S-wave velocity and grid spacing. However, because the characterized source model may not sufficiently support short period components, we should be interpreted the reliable period of this simulation with caution. Therefore, we consider the period more than five seconds instead of two seconds for further analysis. We evaluate the long-period ground motions using the velocity response spectra for the period range between five and 20 second. The preliminary simulation shows a large variation of response spectra at a site. This large variation implies that the ground motion is very sensitive to different scenarios. And it requires studying the large variation to understand the seismic hazard. Our further study will obtain the hazard curves for the Nankai Trough earthquake (M 8~9) by applying the probabilistic seismic hazard analysis to the simulation results.

Ensemble-based diagnosis of the large-scale processes associated with multiple high-impact weather events over North America during late October 2007

NASA Astrophysics Data System (ADS)

Moore, B. J.; Bosart, L. F.; Keyser, D.

2013-12-01

During late October 2007, the interaction between a deep polar trough and Tropical Cyclone (TC) Kajiki off the eastern Asian coast perturbed the North Pacific jet stream and resulted in the development of a high-amplitude Rossby wave train extending into North America, contributing to three concurrent high-impact weather events in North America: wildfires in southern California associated with strong Santa Ana winds, a cold surge into eastern Mexico, and widespread heavy rainfall (~150 mm) in the south-central United States. Observational analysis indicates that these high-impact weather events were all dynamically linked with the development of a major high-latitude ridge over the eastern North Pacific and western North America and a deep trough over central North America. In this study, global operational ensemble forecasts from the European Centre for Medium-Range Weather Forecasts (ECMWF) obtained from The Observing System Research and Predictability Experiment (THORPEX) Interactive Grand Global Ensemble (TIGGE) archive are used to characterize the medium-range predictability of the large-scale flow pattern associated with the three events and to diagnose the large-scale atmospheric processes favorable, or unfavorable, for the occurrence of the three events. Examination of the ECMWF forecasts leading up to the time period of the three high-impact weather events (~23-25 October 2007) indicates that ensemble spread (i.e., uncertainty) in the 500-hPa geopotential height field develops in connection with downstream baroclinic development (DBD) across the North Pacific, associated with the interaction between TC Kajiki and the polar trough along the eastern Asian coast, and subsequently moves downstream into North America, yielding considerable uncertainty with respect to the structure, amplitude, and position of the ridge-trough pattern over North America. Ensemble sensitivity analysis conducted for key sensible weather parameters corresponding to the three high-impact weather events, including relative humidity, temperature, and precipitation, demonstrates quantitatively that all three high-impact weather events are closely linked with the development of the ridge-trough pattern over North America. Moreover, results of this analysis indicate that the development of the ridge-trough pattern is modulated by DBD and cyclogenesis upstream over the central and eastern North Pacific. Specifically, ensemble members exhibiting less intense cyclogenesis and a more poleward cyclone track over the central and eastern North Pacific feature the development of a poleward-displaced ridge over the eastern North Pacific and western North America and a cut-off low over the Intermountain West, an unfavorable scenario for the occurrence the three high-impact weather events. Conversely, ensemble members exhibiting more intense cyclogenesis and a less poleward cyclone track feature persistent ridging along the western coast of North America and trough development over central North America, establishing a favorable flow pattern for the three high-impact weather events. Results demonstrate that relatively small initial differences in the large-scale flow pattern over the North Pacific among ensemble members can result in large uncertainty in the forecast downstream flow response over North America.

Morphotectonics of the central Muertos thrust belt and Muertos Trough (northeastern Caribbean)

USGS Publications Warehouse

Granja, Bruna J.L.; ten Brink, Uri S.; Carbó-Gorosabel, Andrés; Muñoz-Martín, A.; Gomez, Ballesteros M.

2009-01-01

Multibeam bathymetry data acquired during the 2005 Spanish R/V Hesp??rides cruise and reprocessed multichannel seismic profiles provide the basis for the analysis of the morphology and deformation in the central Muertos Trough and Muertos thrust belt. The Muertos Trough is an elongated basin developed where the Venezuelan Basin crust is thrusted under the Muertos fold-and-thrust belt. Structural variations along the Muertos Trough are suggested to be a consequence of the overburden of the asymmetrical thrust belt and by the variable nature of the Venezuelan Basin crust along the margin. The insular slope can be divided into three east-west trending slope provinces with high lateral variability which correspond to different accretion stages: 1) The lower slope is composed of an active sequence of imbricate thrust slices and closed fold axes, which form short and narrow accretionary ridges and elongated slope basins; 2) The middle slope shows a less active imbricate structure resulting in lower superficial deformation and bigger slope basins; 3) The upper slope comprises the talus region and extended terraces burying an island arc basement and an inactive imbricate structure. The talus region is characterized by a dense drainage network that transports turbidite flows from the islands and their surrounding carbonate platform areas to the slope basins and sometimes to the trough. In the survey area the accommodation of the ongoing east-west differential motion between the Hispaniola and the Puerto Rico-Virgin Islands blocks takes place by means of diffuse deformation. The asymmetrical development of the thrust belt is not related to the geological conditions in the foreland, but rather may be caused by variations in the geometry and movement of the backstop. The map-view curves of the thrust belt and the symmetry of the recesses suggest a main north-south convergence along the Muertos margin. The western end of the Investigator Fault Zone comprises a broad band of active normal faults which result in high instability of the upper insular slope. ?? 2009 Elsevier B.V.

Enhanced and asymmetric melting beneath the southern Mariana back-arc spreading ridge under the influence of the Pacific plate subduction

NASA Astrophysics Data System (ADS)

Matsuno, T.; Seama, N.; Shindo, H.; Nogi, Y.; Okino, K.

2017-12-01

Back-arc spreading ridges in the southern Mariana Trough are slow-spreading ridges but have features suggesting enhanced melting beneath the ridges and influences on seafloor spreading processes by fluid derived from the subducted Pacific slab underlying the ridges. To reveal melting and dehydration processes and dynamics in the upper mantle in the southern Mariana Trough, we conducted a marine magnetotelluric (MT) experiment along a 120 km-length transect across a ridge segment at 13°N. We obtained electromagnetic field data at 9 stations along the transect, and analyzed them for estimating MT responses, striping seafloor topographic distortion from the responses, and imaging a 2-D electrical resistivity structure by 2-D inversion of TM-mode responses. A resultant 2-D inversion model showed 1) a conductive area at 10-20 km depth beneath the ridge center, the center of which slightly offsets to the trench side, 2) a moderately conductive area expanding asymmetrically around and under the conductor of 1), 3) a resistive area thickening from the ridge center up to about 40 km on the remnant arc side, and 4) a resistive area with a constant thickness of about 150 km on the trench side. These model features suggest 1) a melt body beneath the ridge center, possibly containing slab-derived water 2) water- and melt-retained mantle area produced by hydration of the back-arc mantle wedge and asymmetric passive decompression melting in the hydrous mantle wedge, 3) cooled and residual lithospheric mantle off the ridge center, and 4) mantle wedge and subducted Pacific lithospheric mantle that are both cold and depleted. The electrical resistivity structure obtained in the southern Mariana Trough, which clearly contrasts with the structure of the central Mariana Trough at 18°N in that this lacks a conductor beneath the ridge center, provides insights on the mantle dynamics and its relation to the characteristic tectonics and many kinds of observational results in the southern Mariana Trough.

Inner-shelf circulation and sediment dynamics on a series of shoreface connected ridges offshore of Fire Island, NY

USGS Publications Warehouse

Warner, John C.; List, Jeffrey H.; Schwab, William C.; Voulgaris, George; Armstrong, Brandy N.; Marshall, N

2014-01-01

Locations along the inner-continental shelf offshore of Fire Island, NY, are characterized by a series of shoreface connected ridges (SFCRs). These sand ridges have approximate dimensions of 10 km in length, 3 km spacing, up to ~8 m ridge to trough relief, and are oriented obliquely at approximately 30 degrees clockwise from the coastline. Stability analysis from previous studies explains how sand ridges such as these could be formed and maintained by storm-driven flows directed alongshore with a key maintenance mechanism of offshore deflected flows over ridge crests and onshore in the troughs. We examine these processes both with a limited set of idealized numerical simulations and analysis of observational data. Model results confirm that along-shore flows over the SFCRs exhibit offshore veering of currents over the ridge crests and onshore-directed flows in the troughs, and demonstrate the opposite circulation pattern for a reverse wind. To further investigate these maintenance processes, oceanographic instruments were deployed at seven sites on the SFCRs offshore of Fire Island to measure water levels, ocean currents, waves, suspended-sediment concentrations, and bottom stresses from January to April 2012. Data analysis reveals that during storms with winds from the northeast the processes of offshore deflection of currents over ridge crests and onshore in the troughs were observed, and during storm events with winds from the southwest a reverse flow pattern over the ridges occurred. Computations of suspended-sediment fluxes identify periods that are consistent with SFCR maintenance mechanisms. Alongshore winds from the northeast drove fluxes offshore on the ridge crest and onshore in the trough that would tend to promote ridge maintenance. However, alongshore winds from the southwest drove opposite circulations. The wind fields are related to different storm types that occur in the region (low pressure systems, cold fronts, and warm fronts). From the limited data set we identify that low pressure systems drive sediment fluxes that tend to promote stability and maintain the SFCRs, while cold front type storms appear to drive circulations that are in the opposite sense and may not be a supporting mechanism for ridge maintenance.

Declining Nutrient Concentrations in the Northeast Atlantic as a Result of a Weakening Subpolar Gyre

NASA Technical Reports Server (NTRS)

Johnson, Clare; Inall, Mark; Hakkinen, Sirpa

2013-01-01

Between 1996 and the mid-2000s the upper waters (200-700 m) of the Rockall Trough became warmer (+0.72 C), saltier (+0.088) and reduced in nitrate and phosphate (-2.00 Micron and -0.14 Micron respectively). These changes, out-with calculated errors, can be explained by the varying influence of southern versus subpolar water masses in the basin as the Subpolar Gyre weakened and contracted. Upper water properties strongly correlate with a measure of the strength of the Subpolar Gyre (the first principal component of sea surface height over the Subpolar North Atlantic) prior to the mid-2000s. As the gyre weakens, the upper layers of the trough become warmer (r -0.85), more saline (r -0.86) and reduced in nitrate and phosphate (r +0.81 and r +0.87 respectively). Further the proportion of subpolar waters in the basin decreases from around 50% to less than 20% (r +0. 88). Since the mid-2000s the Subpolar Gyre has been particularly weak. During this period temperatures decreased slightly (-0.21 1C), salinities remained near constant (35.410 +/- 0.005) and phosphate levels low and stable (0.68 +/- 0.02 Micron). These relative lack of changes are thought to be related to the maximum proportion of southern water masses within the Rockall Trough having been reached. Thus the upper water properties are no longer controlled by changes in the relative importance of different water masses in the basin (as prior to the mid-2000s), but rather a different process. We suggest that when the gyre is particularly weak the interannual changes in upper water properties in the Rockall Trough reflect changes in the source properties of the southern water masses. Since the early-2000s the Subpolar Gyre has been weaker than observed since 1992, or modelled since 1960-1970. Hence upper waters within the Rockall Trough may be warmer, saltier and more depleted in nitrate and phosphate than at any time in the last half century.

The tug-of-war between the West Philippine Sea and South China Sea Tropical Waters and Intermediate Waters in the Okinawa Trough

NASA Astrophysics Data System (ADS)

Chen, C. T. A.

2015-12-01

It has been known that Kuroshio subsurface waters are the major source of nutrients to the East China Sea continental shelf, a major fishing ground. It has also been known that subsurface waters that upwell onto the shelf are heavily affected by the South China Sea (SCS) Tropical Water and the SCS Intermediate Water which contain more nutrients than the tropical (Smax) and intermediate (Smin) waters from the West Philippine Sea (WPS). A front has been found to separate the tropical and intermediate waters from the SCS and WPS. The reported front in the Okinawa Trough, however, was identified based only on one-time data from a single cross-section in the central Okinawa Trough. Here historical hydrographic data between Mar. 1950 and Dec. 2011 in the Okinawa Trough and its neighborhood are analyzed. A vertical front tilted toward the west is found in all seasons in all years across the World Ocean Circulation Repeated Lines PR 18 and 19 as well as at the PN cross-section in the central Okinawa Trough. The front at the Smax level (sigma theta=24.6-24.9) shows large seasonal and interannual variations. In winter during normal and La Niña periods the presence of the SCS Tropical Water is the most prominent. It is the weakest in autumn during normal periods and in spring during La Nina periods. Yet during El Niño periods the SCS Tropical Water is the most prominent in spring and it becomes the weakest in winter. As for intermediate waters (Smin at sigma theta= 26.7-26.9) the WPS Intermediate Water and SCS Intermediate Water show much weaker seasonality compared with tropical waters although during normal periods in winter the WPS Intermediate Water contribution is slightly larger than during other times. During El Niño periods the WPS Intermediate Water contribution is the smallest but in spring it is much strengthened. On the other hand, the WPS Intermediate Water contribution is the smallest in spring, and the largest in winter during La Niña periods.

New Insight Into the Crustal Structure of the Continental Margin offshore NW Sabah/Borneo

NASA Astrophysics Data System (ADS)

Barckhausen, U.; Franke, D.; Behain, D.; Meyer, H.

2002-12-01

The continental margin offshore NW Sabah/Borneo (Malaysia) has been investigated with reflection and refraction seismics, magnetics, and gravity during the recent cruise BGR01-POPSCOMS. A total of 4000 km of geophysical profiles has been acquired, thereof 2900 km with reflection seismics. The focus of investigations was on the deep water areas. The margin looks like a typical accretionary margin and was presumably formed during the subduction of a proto South China Sea. Presently, no horizontal movements between the two plates are being observed. Like in major parts of the South China Sea, the area seaward of the Sabah Trough consists of extended continental lithosphere which is characterised by a pattern of rotated fault blocks and half grabens and a carbonate platform of Early Oligocene to Early Miocene age. We found evidence that the continental crust also underlies the Sabah Trough and the adjacent continental slope, a fact that raises many questions about the tectonic history and development of this margin. The tectonic pattern of the Dangerous Grounds' extended continental crust can be traced a long way landward of the Sabah Trough beneath the sedimentary succession of the upper plate. The magnetic anomalies which are dominated by the magnetic signatures of relatively young volcanic features also continue under the continental slope. The sedimentary rocks of the upper plate, in contrast, seem to generate hardly any magnetic anomalies. Based on the new data we propose the following scenario for the development of the NW Sabah continental margin: Seafloor spreading in the present South China Sea started at about 30 Ma in the Late Oligocene. The spreading process separated the Dangerous Grounds area from the SE Asian continent and ceased in late Early Miocene when the oceanic crust of the proto South China Sea was fully subducted in eastward direction along the Borneo-Palawan Trough. During Lower and/or Middle Miocene, Borneo rotated counterclockwise and was thrusted onto the edge of the rifted continental block of the Dangerous Grounds. The subducted oceanic crust of the proto South China Sea must today be located below the Eastern part of Sabah and not along the present NW Sabah Trough.

Early glaciation already during the Early Miocene in the Amundsen Sea, Southern Pacific: Indications from the distribution of sedimentary sequences

NASA Astrophysics Data System (ADS)

Uenzelmann-Neben, Gabriele; Gohl, Karsten

2014-09-01

The distribution and internal architecture of seismostratigraphic sequences observed on the Antarctic continental slope and rise are results of sediment transport and deposition by bottom currents and ice sheets. Analysis of seismic reflection data allows to reconstruct sediment input and sediment transport patterns and to infer past changes in climate and oceanography. We observe four seismostratigraphic units which show distinct differences in location and shape of their depocentres and which accumulated at variable sedimentation rates. We used an age-depth model based on DSDP Leg 35 Site 324 for the Plio/Pleistocene and a correlation with seismic reflection characteristics from the Ross and Bellingshausen Seas, which unfortunately has large uncertainties. For the period before 21 Ma, we interpret low energy input of detritus via a palaeo-delta originating in an area of the Amundsen Sea shelf, where a palaeo-ice stream trough (Pine Island Trough East, PITE) is located today, and deposition of this material on the continental rise under sea ice coverage. For the period 21-14.1 Ma we postulate glacial erosion for the hinterland of this part of West Antarctica, which resulted in a larger depocentre and an increase in mass transport deposits. Warming during the Mid Miocene Climatic Optimum resulted in a polythermal ice sheet and led to a higher sediment supply along a broad front but with a focus via two palaeo-ice stream troughs, PITE and Abbot Trough (AT). Most of the glaciogenic debris was transported onto the eastern Amundsen Sea rise where it was shaped into levee-drifts by a re-circulating bottom current. A reduced sediment accumulation in the deep-sea subsequent to the onset of climatic cooling after 14 Ma indicates a reduced sediment supply probably in response to a colder and drier ice sheet. A dynamic ice sheet since 4 Ma delivered material offshore mainly via AT and Pine Island Trough West (PITW). Interaction of this glaciogenic detritus with a west-setting bottom current resulted in the continued formation of levee-drifts in the eastern and central Amundsen Sea.

Imaging of Upper-Mantle Upwelling Beneath the Salton Trough, Southern California, by Joint Inversion of Ambient Noise Dispersion Curves and Receiver Functions

NASA Astrophysics Data System (ADS)

Klemperer, S. L.; Barak, S.

2016-12-01

We present a new 2D shear-wave velocity model of the crust and upper-mantle across the Salton Trough, southern California, obtained by jointly inverting our new dataset of receiver functions and our previously published Rayleigh-wave group-velocity model (Barak et al., G-cubed, 2015), obtained from ambient-noise tomography. Our results show an upper-mantle low-velocity zone (LVZ) with Vs ≤4.2 km/s extending from the Elsinore Fault to the Sand Hills Fault, that together bracket the full width of major San Andreas dextral motion since its inception 6 Ma b.p., and underlying the full width of low topography of the Imperial Valley and Salton Trough. The lateral extent of the LVZ is coincident with the lateral extent of an upper-mantle anisotropic region interpreted as a zone of SAF-parallel melt pockets (Barak & Klemperer, Geology, 2016). The shallowest part of the LVZ is 40 km depth, coincident with S-receiver function images. The western part of the LVZ, between the Elsinore and San Jacinto faults (the region of greatest modern dextral slip), appears to continue to significantly greater depth; but a puzzling feature of our preliminary models is that the eastern part of the LVZ, from the San Jacinto Fault to the Sand Hills Fault, appears to be underlain by more-normalvelocity upper mantle (Vs ≥ 4.5 km/s) below 75 km depth. We compare our model to the current SCEC community models CVM-H and CVM-S, and to P-wave velocity models obtained by the active-source Salton Sea Imaging Project (SSIP). The hypothesized lower-crustal low-velocity zone beneath the Salton Trough in our previous model (Barak et al., G-cubed, 2015), there interpreted as a region of partial melt, is not supported by our new modeling. Melt may be largely absent from the lower crust of the Salton trough; but appears required in the upper mantle at depths as shallow as 40 km.

Bathymetry and oceanic flow structure at two deep passages crossing the Lomonosov Ridge

NASA Astrophysics Data System (ADS)

Björk, Göran; Jakobsson, Martin; Assmann, Karen; Andersson, Leif G.; Nilsson, Johan; Stranne, Christian; Mayer, Larry

2018-01-01

The Lomonosov Ridge represents a major topographical feature in the Arctic Ocean which has a large effect on the water circulation and the distribution of water properties. This study presents detailed bathymetric survey data along with hydrographic data at two deep passages across the ridge: a southern passage (80-81° N), where the ridge crest meets the Siberian continental slope, and a northern passage around 84.5° N. The southern channel is characterized by smooth and flat bathymetry around 1600-1700 m with a sill depth slightly shallower than 1700 m. A hydrographic section across the channel reveals an eastward flow with Amundsen Basin properties in the southern part and a westward flow of Makarov Basin properties in the northern part. The northern passage includes an approximately 72 km long and 33 km wide trough which forms an intra-basin in the Lomonosov Ridge morphology (the Oden Trough). The eastern side of the Oden Trough is enclosed by a narrow and steep ridge rising 500-600 m above a generally 1600 m deep trough bottom. The deepest passage (the sill) is 1470 m deep and located on this ridge. Hydrographic data show irregular temperature and salinity profiles indicating that water exchange occurs as midwater intrusions bringing water properties from each side of the ridge in well-defined but irregular layers. There is also morphological evidence that some rather energetic flows may occur in the vicinity of the sill. A well expressed deepening near the sill may be the result of seabed erosion by bottom currents.

Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data.

PubMed

Acosta, Edward P; Limoli, Kay L; Trinh, Lan; Parkin, Neil T; King, Jennifer R; Weidler, Jodi M; Ofotokun, Ighovwerha; Petropoulos, Christos J

2012-11-01

Durable suppression of HIV-1 replication requires the establishment of antiretroviral drug concentrations that exceed the susceptibility of the virus strain(s) infecting the patient. Minimum plasma drug concentrations (C(trough)) are correlated with response, but determination of target C(trough) values is hindered by a paucity of in vivo concentration-response data. In the absence of these data, in vitro susceptibility measurements, adjusted for serum protein binding, can provide estimations of suppressive in vivo drug concentrations. We derived serum protein binding correction factors (PBCF) for protease inhibitors, nonnucleoside reverse transcriptase inhibitors, and an integrase inhibitor by measuring the effect of a range of human serum concentrations on in vitro drug susceptibility measured with the PhenoSense HIV assay. PBCFs corresponding to 100% HS were extrapolated using linear regression and ranged from 1.4 for nevirapine to 77 for nelfinavir. Using the mean 95% inhibitory concentration (IC(95)) for ≥1,200 drug-susceptible viruses, we calculated protein-bound IC(95) (PBIC(95)) values. PBIC(95) values were concordant with the minimum effective C(trough) values that were established in well-designed pharmacodynamic studies (e.g., indinavir, saquinavir, and amprenavir). In other cases, the PBIC(95) values were notably lower (e.g., darunavir, efavirenz, and nevirapine) or higher (nelfinavir and etravirine) than existing target recommendations. The establishment of PBIC(95) values as described here provides a convenient and standardized approach for estimation of the minimum drug exposure that is required to maintain viral suppression and prevent the emergence of drug-resistant variants, particularly when in vivo concentration-response relationships are lacking.

A tale of seven narrow spikes and a long trough: constraining the timing of the percolation of H II bubbles at the tail end of reionization with ULAS J1120+0641

NASA Astrophysics Data System (ADS)

Chardin, Jonathan; Haehnelt, Martin G.; Bosman, Sarah E. I.; Puchwein, Ewald

2018-01-01

High signal-to-noise observations of the Ly α forest transmissivity in the z = 7.085 quasi-stellar object (QSO) ULAS J1120+0641 show seven narrow transmission spikes followed by a long 240 cMpc h-1 trough. Here, we use radiative transfer simulations of cosmic reionization previously calibrated to match a wider range of Ly α forest data to show that the occurrence of seven transmission spikes in the narrow redshift range z = 5.85-6.1 is very sensitive to the exact timing of reionization. Occurrence of the spikes requires the most underdense regions of the intergalactic medium to be already fully ionized. The rapid onset of a long trough at z = 6.12 requires a strong decrease of the photoionization rate Γ at z ≳ 6.1 in this line of sight, consistent with the end of percolation at this redshift. The narrow range of reionization histories that we previously found to be consistent with a wider range of Ly α forest data have a reasonable probability of showing seven spikes and the mock absorption spectra provide an excellent match to the spikes and the trough in the observed spectrum of ULAS J1120+0641. Larger samples of high signal-to-noise searches for rare Ly α transmission spikes at z > 5.8 should therefore provide important further insights into the exact timing of the percolation of H II bubbles at the tail end of reionization.

Experimental study on melting and flowing behavior of thermoplastics combustion based on a new setup with a T-shape trough.

PubMed

Xie, Qiyuan; Zhang, Heping; Ye, Ruibo

2009-07-30

The objective of this work is to quantitatively study the burning characteristics of thermoplastics. A new experimental setup with a T-shape trough is designed. Based on this setup, the loop mechanism between the wall fire and pool fires induced by the melting and dripping of thermoplastic can be well simulated and studied. Additionally, the flowing characteristics of pool fires can also be quantitatively analyzed. Experiments are conducted for PP and PE sheets with different thicknesses. The maximum distances of the induced flowing pool flame in the T-shape trough are recorded and analyzed. The typical fire parameters, such as heat release rates (HRRs), CO concentrations are also monitored. The results show that the softening and clinging of the thermoplastic sheets plays a considerable role for their vertical wall burning. It is illustrated that the clinging of burning thermoplastic sheet may be mainly related with the softening temperatures and the ignition temperatures of the thermoplastics, as well as their viscosity coefficients. Through comparing the maximum distances of flowing flame of induced pool fires in the T-shape trough for thermoplastic sheets with different thicknesses, it is indicated that the pool fires induced by PE materials are easier to flow away than that of PP materials. Therefore, PE materials may be more dangerous for their faster pool fire spread on the floor. These experimental results preliminarily illustrate that this new experimental setup is helpful for quantitatively studying the special burning feature of thermoplastics although further modifications is needed for this setup in the future.

Antibodies against Hepatitis A and Hepatitis B Virus in Intravenous Immunoglobulin Products.

PubMed

Lee, Soyoung; Kim, Han Wool; Kim, Kyung Hyo

2016-12-01

The worldwide seroprevalence of hepatitis A virus (HAV) and hepatitis B virus (HBV) has changed over the last two decades, indicating a declining incidence of HAV and HBV infections. Therefore, vaccinations against HAV and HBV are recommended for unimmunized people before traveling to an endemic area. Unfortunately, primary antibody deficiency (PAD) patients can only obtain humoral immunity through intravenous immunoglobulin G (IVIG) replacement and not from vaccination because of a defect in antibody production. However, few studies have analyzed the titers of antibodies against HAV or HBV in IVIG products. In this study, the titers of anti-HAV and anti-HBs antibodies were measured in nineteen lots of IVIG products from five manufacturers from three countries (A, B from Korea; C, D from Japan; and E from the USA), and trough titers in plasma were estimated. Concentrations of anti-HAV antibody ranged from 1,888-8,927 mIU/mL and estimated trough titers exceeded the minimal protective value in all evaluated IVIG products. Concentrations of anti-HBs antibody ranged from 438-965 mIU/mL in products A and B and were 157, 123, and 1,945 mIU/mL in products C, D, and E, respectively. Estimated trough titers in products A, B, and E exceeded the minimal protective value but those in products C and D did not reach this threshold. These data demonstrated that available IVIG products generally provide sufficient antibodies against HAV and HBV to protect patients with PAD, although the trough concentrations of anti-HBs antibody in two IVIG products did not reach the minimum protective value.

The influence of genetic polymorphisms of cytochrome P450 3A5 and ABCB1 on starting dose- and weight-standardized tacrolimus trough concentrations after kidney transplantation in relation to renal function.

PubMed

Mourad, Michel; Wallemacq, Pierre; De Meyer, Martine; Brandt, Dimitri; Van Kerkhove, Valérie; Malaise, Jacques; Chaïb Eddour, Djamila; Lison, Dominique; Haufroid, Vincent

2006-01-01

Cytochrome P450 3A5 (CYP3A5) and ABCB1 polymorphisms have been shown to influence tacrolimus (Tc) blood concentrations in the stable phase after organ transplantation. We hypothesized that Tc pharmacokinetics may be affected by genetic mutations subsequent to starting doses. We retrospectively analyzed data from a cohort of 59 kidney transplant recipients, in whom CYP3A5 (intron 3) and ABCB1 (exons 12, 21 and 26) genotypes were correlated to dose- and weight-standardized Tc trough concentrations obtained after initial Tc doses. Renal function, expressed as glomerular filtration rate (GFR) (MDRD equation), on days 7 and 14 after transplantation was evaluated and its relationship with Tc concentrations was analyzed. Dose- and weight-standardized Tc trough concentrations were lower in patients carrying the CYP3A5 *1 allele (p<0.01). There was no statistically significant association with ABCB1 polymorphisms. In a multivariate analysis, both the presence of at least one CYP3A5 *1 allele (p=0.006) and age at the time of transplantation (p=0.010) were significant independent variables affecting Tc trough blood concentrations standardized to the first dosages (model r2=0.23). GFR was not affected by Tc concentrations. Prospective trials are needed to prove that a genetic approach to Tc pharmacokinetics and its related side effects during the early period after grafting may improve patient outcome.

The fabrication and visible-near-infrared optical modulation of vanadium dioxide/silicon dioxide composite photonic crystal structure

NASA Astrophysics Data System (ADS)

Liang, Jiran; Li, Peng; Song, Xiaolong; Zhou, Liwei

2017-12-01

We demonstrated a visible and near-infrared light tunable photonic nanostructure, which is composed of vanadium dioxide (VO2) thin film and silicon dioxide (SiO2) ordered nanosphere arrays. The vanadium films were sputtered on two-dimensional (2D) SiO2 sphere arrays. VO2 thin films were prepared by rapid thermal annealing (RTA) method with different oxygen flow rates. The close-packed VO2 shell formed a continuous surface, the composition of VO2 films in the structure changed when the oxygen flow rates increased. The 2D VO2/SiO2 composite photonic crystal structure exhibited transmittance trough tunability and near-infrared (NIR) transmittance modulation. When the oxygen flow rate increased from 3 slpm to 4 slpm, the largest transmittance trough can be regulated from 904 to 929 nm at low temperature, the transmittance troughs also appear blue shift when the VO2 phase changes from insulator to metal. The composite nanostructure based on VO2 films showed visible transmittance tunability, which would provide insights into the glass color changing in smart windows.

New insights into the origin of the bimodal volcanism in the middle Okinawa Trough: not a basalt-rhyolite differentiation process

NASA Astrophysics Data System (ADS)

Zhang, Yuxiang; Zeng, Zhigang; Chen, Shuai; Wang, Xiaoyuan; Yin, Xuebo

2018-06-01

In the middle Okinawa Trough (MOT), rhyolites have been typically considered as products of crystallization differentiation of basaltic magma as a feature of bimodal volcanism. However, the evidence is insufficient. This paper compared chemical trends of volcanic rocks from the MOT with fractional crystallization simulation models and experimental results and utilized trace element modeling combined with Rayleigh fractionation calculations to re-examine fractional crystallization processes in generating rhyolites. Both qualitative and quantitative studies indicate that andesites, rather than rhyolites, originate by fractional crystallization from basalts in the MOT. Furthermore, we established two batch-melting models for the MOT rhyolites and proposed that type 1 rhyolites are produced by remelting of andesites with amphiboles in the residue, while type 2 rhyolites are derived from remelting of andesites without residual amphiboles. It is difficult to produce melts with a SiO2 content ranging from 62% to 68% either by magmatic differentiation from basalts or by remelting of andesites, and this difficulty might help account for the compositional gap (Daly gap) for bimodal volcanism in the Okinawa Trough.

The Cu-Zn superoxide dismutase (SOD1) inhibits ERK phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Secondo, Agnese; De Mizio, Mariarosaria; Zirpoli, Laura

The Cu-Zn superoxide dismutase (SOD1) belongs to a family of isoenzymes that are able to dismutate the oxygen superoxide in hydrogen peroxide and molecular oxygen. This enzyme is secreted by many cellular lines and it is also released trough a calcium-dependent depolarization mechanism involving SNARE protein SNAP 25. Using rat pituitary GH3 cells that express muscarinic receptors we found that SOD1 inhibits P-ERK1/2 pathway trough an interaction with muscarinic M1 receptor. This effect is strengthened by oxotremorine, a muscarinic M agonist and partially reverted by pyrenzepine, an antagonist of M1 receptor; moreover this effect is independent from increased intracellular calciummore » concentration induced by SOD1. Finally, P-ERK1/2 inhibition was accompanied by the reduction of GH3 cell proliferation. These data indicate that SOD1 beside the well studied antioxidant properties can be considered as a neuromodulator able to affect mitogen-activated protein kinase in rat pituitary cells trough a M1 muscarinic receptor.« less

Exploration gaps exist in Nigeria`s prolific delta

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, D.

The Niger delta region of the Republic of Nigeria is Africa`s largest oil producing area. It is clear that Nigeria will continue to contribute significantly to world petroleum production well into the 21st century: with increases in recoverable oil reserves in the Niger delta onshore and offshore; the promising potential of the Niger delta deepwater region; and a lesser but not insignificant contribution from the unexplored onshore Benue trough, part of the mid-African rift system, which has already proved to hold substantial oil reserves in the Doba basin of neighboring Chad. This is the first of five parts on Nigeria`smore » oil and gas potential. The later articles deal with Niger delta oil reserves and production, Niger delta gas reserves, the delta`s deepwater region, and the Benue trough and onshore cretaceous rift basins. This article deals with the geologic setting of the Niger delta-Benue trough region, the synrift deposits, marine sedimentation, margin evolution, geologic strata and reservoirs, reservoir character, structure and traps, hydrocarbon types, geotemperatures, and source rock quality.« less

Anti-adalimumab antibodies in juvenile idiopathic arthritis-related uveitis.

PubMed

Leinonen, Sanna T; Aalto, Kristiina; Kotaniemi, Kaisu M; Kivelä, Tero T

2017-01-01

To evaluate the association of adalimumab trough levels and anti-adalimumab antibodies with activity of uveitis in juvenile idiopathic arthritis-related uveitis. This was a retrospective observational case series in a clinical setting at the Department of Ophthalmology, Helsinki University Hospital, Finland in 2014-2016. Thirty-one paediatric patients with chronic anterior juvenile idiopathic arthritis-related uveitis in 58 eyes and who had been on adalimumab ≥6 months were eligible for the study. Uveitis activity during adalimumab treatment, adalimumab trough levels and anti-adalimumab antibody levels were recorded. Anti-adalimumab antibody levels ≥12 AU /ml were detected in nine patients (29%). This level of anti-adalimumab antibodies was associated with a higher grade of uveitis (p<0.001), uveitis that was not in remission (p=0.001) and with lack of concomitant methotrexate therapy (p=0.043). In patients with anti-adalimumab antibody levels <12 AU/ml, higher serum trough levels did not associate with better control of uveitis (p=0.86). Adalimumab treatment might be better guided by monitoring anti-adalimumab antibody formation in treating JIA-related uveitis.

Multilevel groundwater monitoring of hydraulic head and temperature in the eastern Snake River Plain aquifer, Idaho National Laboratory, Idaho, 2009–10

USGS Publications Warehouse

Twining, Brian V.; Fisher, Jason C.

2012-01-01

During 2009 and 2010, the U.S. Geological Survey’s Idaho National Laboratory Project Office, in cooperation with the U.S. Department of Energy, collected quarterly, depth-discrete measurements of fluid pressure and temperature in nine boreholes located in the eastern Snake River Plain aquifer. Each borehole was instrumented with a multilevel monitoring system consisting of a series of valved measurement ports, packer bladders, casing segments, and couplers. Multilevel monitoring at the Idaho National Laboratory has been ongoing since 2006. This report summarizes data collected from three multilevel monitoring wells installed during 2009 and 2010 and presents updates to six multilevel monitoring wells. Hydraulic heads (heads) and groundwater temperatures were monitored from 9 multilevel monitoring wells, including 120 hydraulically isolated depth intervals from 448.0 to 1,377.6 feet below land surface. Quarterly head and temperature profiles reveal unique patterns for vertical examination of the aquifer’s complex basalt and sediment stratigraphy, proximity to aquifer recharge and discharge, and groundwater flow. These features contribute to some of the localized variability even though the general profile shape remained consistent over the period of record. Major inflections in the head profiles almost always coincided with low-permeability sediment layers and occasionally thick sequences of dense basalt. However, the presence of a sediment layer or dense basalt layer was insufficient for identifying the location of a major head change within a borehole without knowing the true areal extent and relative transmissivity of the lithologic unit. Temperature profiles for boreholes completed within the Big Lost Trough indicate linear conductive trends; whereas, temperature profiles for boreholes completed within the axial volcanic high indicate mostly convective heat transfer resulting from the vertical movement of groundwater. Additionally, temperature profiles provide evidence for stratification and mixing of water types along the southern boundary of the Idaho National Laboratory. Vertical head and temperature change were quantified for each of the nine multilevel monitoring systems. The vertical head gradients were defined for the major inflections in the head profiles and were as high as 2.1 feet per foot. Low vertical head gradients indicated potential vertical connectivity and flow, and large gradient inflections indicated zones of relatively low vertical connectivity. Generally, zones that primarily are composed of fractured basalt displayed relatively small vertical head differences. Large head differences were attributed to poor vertical connectivity between fracture units because of sediment layering and/or dense basalt. Groundwater temperatures in all boreholes ranged from 10.2 to 16.3˚C. Normalized mean hydraulic head values were analyzed for all nine multilevel monitoring wells for the period of record (2007-10). The mean head values suggest a moderately positive correlation among all boreholes, which reflects regional fluctuations in water levels in response to seasonality. However, the temporal trend is slightly different when the location is considered; wells located along the southern boundary, within the axial volcanic high, show a strongly positive correlation.

Big Opportunities and Big Concerns of Big Data in Education

ERIC Educational Resources Information Center

Wang, Yinying

2016-01-01

Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

Relationships between tinnitus and the prevalence of anxiety and depression.

PubMed

Bhatt, Jay M; Bhattacharyya, Neil; Lin, Harrison W

2017-02-01

Quantify the relationships between tinnitus, and anxiety and depression among adults. Cross-sectional analysis of a national health survey. Adult respondents in the 2007 Integrated Health Interview Series tinnitus module were analyzed. Data for tinnitus symptoms and severity and reported anxiety and depression symptoms were extracted. Associations between tinnitus problems and anxiety, depression, lost workdays, days of alcohol consumption, and mean hours of sleep were assessed. Among 21.4 ± 0.69 million adult tinnitus sufferers, 26.1% reported problems with anxiety in the preceding 12 months, whereas only 9.2% of those without tinnitus reported an anxiety problem (P < .001). Similarly, 25.6% of respondents with tinnitus reported problems with depression, whereas only 9.1% of those without tinnitus reported depression symptoms (P < .001). Those reporting tinnitus symptoms as a "big" or "very big" problem were more likely to concurrently report anxiety (odds ratio [OR]: 5.7; 95% CI: 4.0-8.1; P < .001) and depression (OR: 4.8; 95% CI: 3.5-6.7; P < .001) symptoms. Tinnitus sufferers reported significantly fewer mean hours of sleep per night (7.00 vs. 7.21; P < .001) and greater mean days of work missed (6.94 vs. 3.79, P < .001) compared to those who did not report tinnitus. Mean days of alcohol consumption between the two groups were not significantly different. Tinnitus symptoms are closely associated with anxiety, depression, shorter sleep duration, and greater workdays missed. These comorbidities and sequelae should be recognized and addressed to optimally manage patients with chronic and bothersome tinnitus. 4 Laryngoscope, 2016 127:466-469, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

Vulnerability to exercise addiction, socio-demographic, behavioral and psychological characteristics of runners at risk for eating disorders.

PubMed

Di Lodovico, Laura; Dubertret, Caroline; Ameller, Aurely

2018-02-01

Excessive exercise is frequently associated with eating disorders and may degenerate into exercise addiction. We still don't know whether runners at risk for eating disorders are at risk for exercise addiction. Our aim is to assess: 1) risk for exercise addiction in runners at risk for eating disorders and 2) socio-demographic, behavioral and psychological characteristics distinguishing runners at-risk from not-at-risk for eating disorders. We assessed risk for eating disorders and exercise addiction using the SCOFF questionnaire and the Exercise Addiction Inventory personality traits with the Big-Five Inventory Test, socio-demographic data, eating and training habits in a sample of 154 healthy runners. Twenty five subjects had a score of ≥2 at the SCOFF and were included in the group "at risk for eating disorders". In this group, we found a higher percentage of subjects at risk for exercise addiction (p=0.01) and higher average scores at the Exercise Addiction Inventory (p=0.01) than runners not at risk (N=136). Runners at risk were statistically younger (p=0.03), women (p=0.001), started running to lose weight more often (p=0.03), lost more kilos since affiliation in their running club (p=0.04), and were characterized by neurotic traits using the Big-Five-Inventory Test (p=3.10 -6 ). Screening for exercise addiction and mood disorders could lead to a more accurate management of runners at risk for eating disorders. Identifying vulnerable individuals will facilitate the prevention of eating disorders and preserve the benefits of sport practice. Copyright © 2018. Published by Elsevier Inc.

Landslide in Coprates

NASA Technical Reports Server (NTRS)

2004-01-01

This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows part of a large landslide complex off the north wall of Coprates Chasma in the Valles Marineris trough complex. The wall of Coprates Chasma occupies much of the upper and middle portions of the image; the landslide lobes are on the trough floor in the bottom half of the image. Large boulders the size of houses can be seen on these landslide surfaces. This image is located near 13.9 S, 56.7 W. The picture covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the upper left.

Experimental evaluation of a fixed collector employing vee-trough concentrator and vacuum tube receivers

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1977-01-01

A test bed for experimental evaluation of a fixed solar collector which combines an evacuated glass tube solar receiver with a flat plate/black chrome plated copper absorber and an asymmetric vee-trough concentrator was designed and constructed. Earlier predictions of thermal performance were compared with test data acquired for a bare vacuum tube receiver; and receiver tubes with Alzak aluminum, aluminized FEP Teflon film laminated sheet metal and second surface ordinary mirror reflectors. Test results and system economics as well as objectives of an ongoing program to obtain long-term performance data are discussed.

Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact

PubMed Central

Valerio, Maricela; Muñoz, Patricia; Alcalá, Luis; García-González, Xandra; Burillo, Almudena; Sanjurjo, María; Grau, Santiago

2017-01-01

ABSTRACT Linezolid serum trough (Cmin) and peak (Cmax) levels were determined prospectively in 90 patients. Adequate exposure was defined as a Cmin of 2 to 8 mg/liter. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid Cmin levels was recorded (0.1 to 25.2 μg/ml). Overall, 65.5% of the patients had out-of-range, 41.1% had subtherapeutic, and 24.4% had supratherapeutic trough levels. We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome. PMID:28739788

Alignment method for parabolic trough solar concentrators

DOEpatents

Diver, Richard B [Albuquerque, NM

2010-02-23

A Theoretical Overlay Photographic (TOP) alignment method uses the overlay of a theoretical projected image of a perfectly aligned concentrator on a photographic image of the concentrator to align the mirror facets of a parabolic trough solar concentrator. The alignment method is practical and straightforward, and inherently aligns the mirror facets to the receiver. When integrated with clinometer measurements for which gravity and mechanical drag effects have been accounted for and which are made in a manner and location consistent with the alignment method, all of the mirrors on a common drive can be aligned and optimized for any concentrator orientation.

Object-oriented simulation model of a parabolic trough solar collector: Static and dynamic validation

NASA Astrophysics Data System (ADS)

Ubieta, Eduardo; Hoyo, Itzal del; Valenzuela, Loreto; Lopez-Martín, Rafael; Peña, Víctor de la; López, Susana

2017-06-01

A simulation model of a parabolic-trough solar collector developed in Modelica® language is calibrated and validated. The calibration is performed in order to approximate the behavior of the solar collector model to a real one due to the uncertainty in some of the system parameters, i.e. measured data is used during the calibration process. Afterwards, the validation of this calibrated model is done. During the validation, the results obtained from the model are compared to the ones obtained during real operation in a collector from the Plataforma Solar de Almeria (PSA).

Preparation of nuclear fuel spheres by flotation-internal gelation

DOEpatents

Haas, Paul A.; Fowler, Victor L.; Lloyd, Milton H.

1987-01-01

A simplified internal gelation process for the preparation of gel spheres of nuclear fuels. The process utilizes perchloroethylene as a gelation medium. Gelation is accomplished by directing droplets of a nuclear fuel broth into a moving volume of hot perchloroethylene (about 85.degree. C.) in a trough. Gelation takes place as the droplets float on the surface of the perchloroethylene and the resultant gel spheres are carried directly into an ager column which is attached to the trough. The aged spheres are disengaged from the perchloroethylene on a moving screen and are deposited in an aqueous wash column.

Inductive coupler for downhole components and method for making same

DOEpatents

Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Dahlgren, Scott; Sneddon, Cameron; Fox, Joe; Briscoe, Michael A.

2006-10-03

An inductive coupler for downhole components. The inductive coupler includes an annular housing having a recess defined by a bottom portion and two opposing side wall portions. At least one side wall portion includes a lip extending toward but not reaching the other side wall portion. A plurality of generally U-shaped MCEI segments, preferably comprised of ferrite, are disposed in the recess and aligned so as to form a circular trough. The coupler further includes a conductor disposed within the circular trough and a polymer filling spaces between the segments, the annular housing and the conductor.

Evidence for submarine landslides and continental slope erosion related to fault reactivation during the last glaciation offshore eastern Canada

NASA Astrophysics Data System (ADS)

Saint-Ange, F.; Campbell, C.; MacKillop, K.; Mosher, D. C.; Piper, D. J.; Roger, J.

2012-12-01

Many studies have proposed that reactivation of dormant faults during deglaciation is a source of neotectonic activity in glaciated regions, but few have demonstrated the relationship to submarine landslides. In this study, seabed morphology and shallow geology of the outer continental margin adjacent to the Charlie Gibbs Fracture Zone off Newfoundland, Canada was investigated for evidence of this relationship. The glacial history and morphology of the margin suggest that the entire continental shelf in the area, coincident with major continental crustal lineaments, was ice-covered during the Last glacial cycle, and transverse troughs delineate the paleo-icestream drainage patterns. A recent investigation of Notre Dame Trough revealed the existence of large sediment failures on the shelf. The current study investigates complex seafloor erosion and widespread mass transport deposition (MTD) on the continental slope seaward of Notre Dame Trough, using recently-acquired high resolution seismic reflection data and piston cores. The new data reveal that a trough mouth fan (TMF) is present on the slope seaward of Notre Dame Trough. The Notre Dame TMF is characterized by a succession of stacked debris flows, but does not show a lobate shape in plan view like other classic TMFs. Instead, the Notre Dame TMF has abruptly-truncated margins suggesting post-depositional failure and erosion of the fan deposits. Seismic reflection data show that the locations of the failures along the TMF margin are coincident with a set of shallow faults; however the current dataset does not image the deeper portion of the faults. On the upper slope immediately south of the TMF, a narrow and deeply incised canyon is located along-trend with the Notre Dame Trough. The location of this canyon appears to be controlled by a fault. Downslope from this canyon, along the southern margin of the TMF, a 25 km wide, flat-floored, U-shaped valley was eroded into a succession of stacked MTD-filled channels. Seismic stratigraphic analysis shows that the valley developed around the same time as the adjacent TMF, however, the valley morphology and evidence for repeated slope failure suggests that the processes responsible for its formation were different than the processes that formed the nearby TMF. Age control provided from piston cores suggest that the last major slope failure that contributed to valley formation probably occurred at ~29 ka. Geotechnical measurements from piston cores show slightly underconsolidated sediments. The results indicate that this part of the margin is more unstable than Orphan Basin and Labrador slope regions. Given the low factor of safety and the complex fault system, low energy earthquake from the surrounding area could be enough to potentially trigger landslides.

Influence of trough versus pasture feeding on average daily gain and carcass characteristics in ruminants: a meta-analysis.

PubMed

Agastin, A; Sauvant, D; Naves, M; Boval, M

2014-03-01

Quantitative meta-analysis was run on 108 publications featuring 116 experiments and 399 treatments dealing with the effect of trough or pasture feeding environment (FE) on ruminant performances. The objective was to compare the effect of trough or pasture FE on ADG, diet OM digestibility (OMD), various carcass characteristics, and the interaction between FE and complementation modalities. Live weight was adjusted to compare results between species. Results showed that trough-fed animals had higher ADG (+17.89%; P < 0.001), hot carcass yield (HYield; + 2.47%; P < 0.001) and carcass fat content (+ 24.87%; P < 0.001) than pasture-fed animals but lower carcass muscle and bone percentages (-1.60% [P = 0.010] and -7.63% [P = 0.003], respectively). Feeding environment had no effect on diet OMD (P = 0.818), but the number of observations was low. After considering the addition or not of concentrate in the diet (addiCO), FE effect persisted on ADG (P = 0.024) and carcass fat content (P = 0.027) but not on HYield (P = 0.078) or muscle and bone percentages (P = 0.119 and P = 0.581, respectively). After considering the nature of the concentrate (natCO), FE effect persisted on ADG (P < 0.001) and HYield (P = 0.004). Considering the percentage of concentrate in the diet (PCO) erased FE effect on ADG (P = 0.891) and HYield (P = 0.128). In contrast, considering the quantity of concentrate(QCO) erased FE effect on ADG (P = 0.084) but not on HYield (P = 0.006) or on carcass fat and muscle contents (P = 0.040 and P = 0.040, respectively) although the FE effect on carcass bone content persisted (P = 0.550). Animal species and physiological stage had no effect on any of the variables studied (P > 0.05) but experiment did (P ≤ 0.001). The increase in ADG was positively correlated to HYield in cattle (P = 0.002) and small ruminants (P = 0.003) and positively linked to carcass fat content (P = 0.007) but not carcass muscle content, which actually decreased (P = 0.001). Overall, this meta-analysis confirmed previous reports of FE effects and revealed how the differences generally reported result from a confounding effect of FE and nature of the diet. Indeed, in most of the studies used, trough-fed animals were supplemented with concentrate whereas pasture-fed animals were not. This research also highlighted the fact that pasture-fed animals have the potential to achieve the same performances as trough-fed animals when fed a similar diet.

Thaw pond dynamics and carbon emissions in a Siberian lowland tundra landscape

NASA Astrophysics Data System (ADS)

van Huissteden, Ko; Heijmans, Monique; Dean, Josh; Meisel, Ove; Goovaerts, Arne; Parmentier, Frans-Jan; Schaepman-Strub, Gabriela; Belelli Marchesini, Luca; Kononov, Alexander; Maximov, Trofim; Borges, Alberto; Bouillon, Steven

2017-04-01

Arctic climate change induces drastic changes in permafrost surface wetness. As a result of thawing ground ice bodies, ice wedge troughs and thaw ponds are formed. Alternatively, ongoing thaw may enhance drainage as a result of increased interconnectedness of thawing ice wedge troughs, as inferred from a model study (Liljedahl et al., 2016, Nature Geoscience, DOI: 10.1038/NGEO2674). However, a recent review highlighted the limited predictability of consequences of thawing permafrost on hydrology (Walvoord and Kurylyk, 2016, Vadose Zone J., DOI:10.2136/vzj2016.01.0010). Overall, these changes in tundra wetness modify carbon cycling in the Arctic and in particular the emissions of CO2 and CH4 to the atmosphere, providing a possibly positive feedback on climate change. Here we present the results of a combined remote sensing, geomorphological, vegetation and biogechemical study of thaw ponds in Arctic Siberian tundra, at Kytalyk research station near Chokurdakh, Indigirka lowlands. The station is located in an area dominated by Pleistocene ice-rich 'yedoma' sediments and drained thaw lake bottoms of Holocene age. The development of three types of ponds in the Kytalyk area (polygon centre ponds, ice wedge troughs and thaw ponds) has been traced with high resolution satellite and aerial imagery. The remote sensing data show net areal expansion of all types of ponds. Next to formation of new ponds, local vegetation change from dry vegetation types to wet, sedge-dominated vegetation is common. Thawing ice wedges and thaw ponds show an increase in area and number at most studied locations. In particular the area of polygon centre ponds increased strongly between 2010 and 2015, but this is highly sensitive to antecedent precipitation conditions. Despite a nearly 60% increase of the area of thawing ice wedge troughs, there is no evidence of decreasing water surfaces by increasing drainage through connected ice wedge troughs. The number of thaw ponds shows an equilibrium between newly formed and disappearing ponds, although their net area increased by 16%. The disappearing of ponds was mostly the result of vegetation succession, rather than drainage. This vegetation succession results from an invasion by sedges, followed by establishment of Sphagnum and seedlings of dwarf shrubs. The formation of thaw ponds and troughs resulting from small-scale permafrost collapse results in a drastic change of CH4 and CO2 emissions, from near-zero emission or uptake to high emission. New water surfaces with drowned dry tundra vegetation show the highest emission. However, rapid vegetation succession may mitigate these emissions over time, in particular in the relatively shallow thaw ponds. In contrast, the polygon centre ponds with a stable, oligotrophic vegetation show modest and constant CH4 emission and CO2 uptake.

Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.

PubMed

Miyauchi, Yumi; Sakai, Satoshi; Maeda, Seiji; Shimojo, Nobutake; Watanabe, Shigeyuki; Honma, Satoshi; Kuga, Keisuke; Aonuma, Kazutaka; Miyauchi, Takashi

2012-10-15

Big endothelins (pro-endothelin; inactive-precursor) are converted to biologically active endothelins (ETs). Mammals and humans produce three ET family members: ET-1, ET-2 and ET-3, from three different genes. Although ET-1 is produced by vascular endothelial cells, these cells do not produce ET-3, which is produced by neuronal cells and organs such as the thyroid, salivary gland and the kidney. In patients with end-stage renal disease, abnormal vascular endothelial cell function and elevated plasma ET-1 and big ET-1 levels have been reported. It is unknown whether big ET-2 and big ET-3 plasma levels are altered in these patients. The purpose of the present study was to determine whether endogenous ET-1, ET-2, and ET-3 systems including big ETs are altered in patients with end-stage renal disease. We measured plasma levels of ET-1, ET-3 and big ET-1, big ET-2, and big ET-3 in patients on chronic hemodialysis (n=23) and age-matched healthy subjects (n=17). In patients on hemodialysis, plasma levels (measured just before hemodialysis) of both ET-1 and ET-3 and big ET-1, big ET-2, and big ET-3 were markedly elevated, and the increase was higher for big ETs (Big ET-1, 4-fold; big ET-2, 6-fold; big ET-3: 5-fold) than for ETs (ET-1, 1.7-fold; ET-3, 2-fold). In hemodialysis patients, plasma levels of the inactive precursors big ET-1, big ET-2, and big ET-3 levels are markedly increased, yet there is only a moderate increase in plasma levels of the active products, ET-1 and ET-3. This suggests that the activity of endothelin converting enzyme contributing to circulating levels of ET-1 and ET-3 may be decreased in patients on chronic hemodialysis. Copyright © 2012 Elsevier Inc. All rights reserved.

Big Data: Implications for Health System Pharmacy

PubMed Central

Stokes, Laura B.; Rogers, Joseph W.; Hertig, John B.; Weber, Robert J.

2016-01-01

Big Data refers to datasets that are so large and complex that traditional methods and hardware for collecting, sharing, and analyzing them are not possible. Big Data that is accurate leads to more confident decision making, improved operational efficiency, and reduced costs. The rapid growth of health care information results in Big Data around health services, treatments, and outcomes, and Big Data can be used to analyze the benefit of health system pharmacy services. The goal of this article is to provide a perspective on how Big Data can be applied to health system pharmacy. It will define Big Data, describe the impact of Big Data on population health, review specific implications of Big Data in health system pharmacy, and describe an approach for pharmacy leaders to effectively use Big Data. A few strategies involved in managing Big Data in health system pharmacy include identifying potential opportunities for Big Data, prioritizing those opportunities, protecting privacy concerns, promoting data transparency, and communicating outcomes. As health care information expands in its content and becomes more integrated, Big Data can enhance the development of patient-centered pharmacy services. PMID:27559194

Big Data: Implications for Health System Pharmacy.

PubMed

Stokes, Laura B; Rogers, Joseph W; Hertig, John B; Weber, Robert J

2016-07-01

Big Data refers to datasets that are so large and complex that traditional methods and hardware for collecting, sharing, and analyzing them are not possible. Big Data that is accurate leads to more confident decision making, improved operational efficiency, and reduced costs. The rapid growth of health care information results in Big Data around health services, treatments, and outcomes, and Big Data can be used to analyze the benefit of health system pharmacy services. The goal of this article is to provide a perspective on how Big Data can be applied to health system pharmacy. It will define Big Data, describe the impact of Big Data on population health, review specific implications of Big Data in health system pharmacy, and describe an approach for pharmacy leaders to effectively use Big Data. A few strategies involved in managing Big Data in health system pharmacy include identifying potential opportunities for Big Data, prioritizing those opportunities, protecting privacy concerns, promoting data transparency, and communicating outcomes. As health care information expands in its content and becomes more integrated, Big Data can enhance the development of patient-centered pharmacy services.

Characteristics and origin of Earth-mounds on the Eastern Snake River Plain, Idaho

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tullis, J.A.

1995-09-01

Earth-mounds are common features on the Eastern Snake River Plain, Idaho. The mounds are typically round or oval in plan view, <0.5 m in height, and from 8 to 14 m in diameter. They are found on flat and sloped surfaces, and appear less frequently in lowland areas. The mounds have formed on deposits of multiple sedimentary environments. Those studied included alluvial gravel terraces along the Big Lost River (late Pleistocene/early Holocene age), alluvial fan segments on the flanks of the Lost River Range (Bull Lake and Pinedale age equivalents), and loess/slopewash sediments overlying basalt flows. Backhoe trenches were dugmore » to allow characterization of stratigraphy and soil development. Each mound has features unique to the depositional and pedogenic history of the site; however, there are common elements to all mounds that are linked to the history of mound formation. Each mound has a {open_quotes}floor{close_quotes} of a sediment or basement rock of significantly different hydraulic conductivity than the overlying sediment. These paleosurfaces are overlain by finer-grained sediments, typically loess or flood-overbank deposits. Mounds formed in environments where a sufficient thickness of fine-grained sediment held pore water in a system open to the migration to a freezing front. Heaving of the sediment occurred by the growth of ice lenses. Mound formation occurred at the end of the Late Pleistocene or early in the Holocene, and was followed by pedogenesis. Soils in the mounds were subsequently altered by bioturbation, buried by eolian deposition, and eroded by slopewash runoff. These secondary processes played a significant role in maintaining or increasing the mound/intermound relief.« less

Tectonic controls on deposition of Middle Jurassic strata in a retroarc foreland basin, Utah-Idaho trough, western interior, United States

NASA Astrophysics Data System (ADS)

Bjerrum, Christian J.; Dorsey, Rebecca J.

1995-08-01

An electronic supplement of this material may be obtained on a diskette or Anonymous FTP from KOSMOS.AGU.ORG. (LOGIN to AGU's FTP account using ANONYMOUS as the username and GUEST as the password. Go to the right directory by typing CD APEND. Type LS to see what files are available. Type GET and the name of the file to get it. Finally, type EXIT to leave the system.) (Paper 95TC01448, Tectonic controls on deposition of Middle Jurassic strata in a retroarc foreland basin, Utah-Idaho trough, western interior, United States, Christian J. Bjerrum and Rebecca J. Dorsey). Diskette may be ordered from American Geophysical Union, 2000 Florida Avenue, N. W., Washington, DC 20009; $15.00. Payment must accompany order. A thick succession of Jurassic nonmarine and marine sedimentary rocks is exposed in a large area from northern Arizona to eastern Idaho and western Wyoming. These sediments accumulated in the Utah-Idaho trough, a deep elongate cratonal basin whose origin has recently been debated. Detailed stratigraphic analysis, subsidence analysis, and first-order flexural modeling of these deposits (this study) provide new insights into the timing and mechanisms of subsidence in the Utah-Idaho trough. Lower and Middle Jurassic strata are divided into six unconformity-bounded sequences. In contrast to the overall uniform thickness of Lower Jurassic sequences (1 and 2), Middle Jurassic strata (sequences 3 through 6) consist of distinctly westward thickening sedimentary packages in which basal shallow marine deposits onlap eastward onto bounding unconformities. Basal strata of sequences 3 through 6 pass upward into widespread progradational continental deposits that are truncated progressively toward the east (cratonward) by the next unconformity. Decompacted total subsidence curves show that the rate of subsidence in most sections increased sharply at the end of sequence 2 time (J-2 unconformity; ˜170 Ma). This is interpreted to record the onset of Middle Jurassic deposition in the distal part of a retroarc foreland basin. The unconformities and distinctive stratal geometries may have formed in response to forebulge migration caused by episodic thrusting in the Cordilleran orogen to the west. First-order flexural modeling was carried out to test the hypothesis of flexural subsidence in the Utah-Idaho trough. Trial-and-error comparisons produce a close match between decompacted stratigraphic profiles and model deflection profiles. The best fit is obtained using an infinite elastic plate (D = 1 × 1024 Nm), a moderate load topography, elevated base level, and an overfilled basin. Using recently published tectonic reconstructions for Nevada and Utah, we find close spatial agreement between a large Middle Jurassic fold-thrust belt and the supracrustal load inferred from model simulations. Our integrated basin analysis thus supports the interpretation of some previous studies that the Middle Jurassic Utah-Idaho trough was a retroarc foreland basin that formed east of a belt of regional contractile deformation and crustal thickening in western and central Nevada and southeastern California. Late Jurassic extension and normal faulting in northeastern Nevada may have been related to gravitational collapse of overthickened crust in the Cordilleran orogen. This coincides with a period of slowed subsidence in the Utah-Idaho trough that began at about 157 Ma.

The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study.

PubMed

Moots, Robert J; Xavier, Ricardo M; Mok, Chi Chiu; Rahman, Mahboob U; Tsai, Wen-Chan; Al-Maini, Mustafa H; Pavelka, Karel; Mahgoub, Ehab; Kotak, Sameer; Korth-Bradley, Joan; Pedersen, Ron; Mele, Linda; Shen, Qi; Vlahos, Bonnie

2017-01-01

To assess the incidence of anti-drug antibodies (ADA) in patients with rheumatoid arthritis (RA) treated with the TNF inhibitors etanercept (ETN), adalimumab (ADL), or infliximab (IFX), and determine the potential relationship with trough drug concentration, efficacy, and patient-reported outcomes. This multi-national, non-interventional, cross-sectional study (NCT01981473) enrolled adult patients with RA treated continuously for 6-24 months with ETN, ADL, or IFX. ADA and trough drug concentrations were measured by independent assays ≤2 days before the next scheduled dose. Efficacy measurements included Disease Activity Score 28-joint count (DAS28), low disease activity (LDA), remission, and erythrocyte sedimentation rate (ESR). Targeted medical histories of injection site/infusion reactions, serum sickness, and thromboembolic events were collected. Baseline demographics of the 595 patients (ETN: n = 200; ADL: n = 199; IFX: n = 196) were similar across groups. The mean duration of treatment was 14.6, 13.5, and 13.1 months for ETN, ADL, and IFX, respectively. All ETN-treated patients tested negative for ADA, whereas 31.2% and 17.4% patients treated with ADL and IFX, respectively, tested positive. In ADL- or IFX-treated patients, those with ADA had significantly lower trough drug concentrations. There were negative correlations between trough drug levels and both CRP and ESR in ADL- and IFX-treated patients. DAS28-ESR LDA and remission rates were higher in patients without ADA. The rate of targeted medical events reported was low. ADA were detected in ADL- and IFX-treated but not ETN-treated patients. Patients without ADA generally showed numerically better clinical outcomes than those with ADA. This study was registered on www.ClinicalTrials.gov (NCT01981473).

Examination of the largest-possible tsunamis (Level 2) generated along the Nankai and Suruga troughs during the past 4000 years based on studies of tsunami deposits from the 2011 Tohoku-oki tsunami

NASA Astrophysics Data System (ADS)

Kitamura, Akihisa

2016-12-01

Japanese historical documents reveal that Mw 8 class earthquakes have occurred every 100-150 years along the Suruga and Nankai troughs since the 684 Hakuho earthquake. These earthquakes have commonly caused large tsunamis with wave heights of up to 10 m in the Japanese coastal area along the Suruga and Nankai troughs. From the perspective of tsunami disaster management, these tsunamis are designated as Level 1 tsunamis and are the basis for the design of coastal protection facilities. A Mw 9.0 earthquake (the 2011 Tohoku-oki earthquake) and a mega-tsunami with wave heights of 10-40 m struck the Pacific coast of the northeastern Japanese mainland on 11 March 2011, and far exceeded pre-disaster predictions of wave height. Based on the lessons learned from the 2011 Tohoku-oki earthquake, the Japanese Government predicted the tsunami heights of the largest-possible tsunami (termed a Level 2 tsunami) that could be generated in the Suruga and Nankai troughs. The difference in wave heights between Level 1 and Level 2 tsunamis exceeds 20 m in some areas, including the southern Izu Peninsula. This study reviews the distribution of prehistorical tsunami deposits and tsunami boulders during the past 4000 years, based on previous studies in the coastal area of Shizuoka Prefecture, Japan. The results show that a tsunami deposit dated at 3400-3300 cal BP can be traced between the Shimizu, Shizuoka and Rokken-gawa lowlands, whereas no geologic evidence related to the corresponding tsunami (the Rokken-gawa-Oya tsunami) was found on the southern Izu Peninsula. Thus, the Rokken-gawa-Oya tsunami is not classified as a Level 2 tsunami.

Towards to Resilience Science -Research on the Nankai trough seismogenic zone-

NASA Astrophysics Data System (ADS)

Kaneda, Yoshiyuki; Shiraki, Wataru; Fujisawa, Kazuhito; Tokozakura, Eiji

2017-04-01

For the last few decades, many destructive earthquakes and tsunamis occurred in the world. Based on lessons learnt from 2004 Sumatra Earthquake/Tsunamis, 2010 Chilean Earthquake/Tsunami and 2011 East Japan Earthquake/Tsunami, we recognized the importance of real time monitoring on Earthquakes and Tsunamis for disaster mitigation. Recently, Kumamoto Earthquake occurred in 2006. This destructive Earthquake indicated that multi strong motions including pre shock and main shock generated severe earthquake damages buildings. Furthermore, we recognize recovers/ revivals are very important and difficult. In Tohoku area damaged by large tsunamis, recovers/revivals have been under progressing after over 5 years passed after the 2011 Tohoku Earthquake. Therefore, we have to prepare the pre plan before next destructive disasters such as the Nankai trough mega thrust earthquake. As one of disaster countermeasures, we would like to propose that Disaster Mitigation Science. This disaster mitigation science is including engineering, science, medicine and social science such as sociology, informatics, law, literature, art, psychology etc. For Urgent evacuations, there are some kinds of real time monitoring system such as Dart buoy and ocean floor network. Especially, the real time monitoring system using multi kinds of sensors such as the accelerometer, broadband seismometer, pressure gauge, difference pressure gauge, hydrophone and thermometer is indispensable for Earthquakes/ Tsunamis monitoring. Furthermore, using multi kind of sensors, we can analyze and estimate broadband crustal activities around mega thrust earthquake seismogenic zones. Therefore, we deployed DONET1 and DONET2 which are dense ocean floor networks around the Nankai trough Southwestern Japan. We will explain about Resilience Science and real time monitoring systems around the Nankai trough seismogenic zone.

Therapeutic drug monitoring of eculizumab: Rationale for an individualized dosing schedule.

PubMed

Gatault, Philippe; Brachet, Guillaume; Ternant, David; Degenne, Danielle; Récipon, Guillaume; Barbet, Christelle; Gyan, Emmanuel; Gouilleux-Gruart, Valérie; Bordes, Cécile; Farrell, Alexandra; Halimi, Jean Michel; Watier, Hervé

2015-01-01

The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic-uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding of eculizumab pharmacokinetics and subsequent individual dose adjustment could reduce this cost. We measured the trough eculizumab concentration in 9 patients with maintenance therapy (aHUS, n = 7; PNH, n = 2) and determined: 1) the intra- and inter-individual variability; 2) the influence of weight on eculizumab pharmacokinetics; and 3) the rate of elimination of eculizumab following discontinuation. A one-compartment model was developed to describe the pharmacokinetics of eculizumab and predicted complement activity by body weight. Trough eculizumab concentrations were >50 µg/mL in 9/9, >100 µg/mL in 8/9, and >300 µg/mL in 5/9 of patients. Intra-individual variability was low but eculizumab concentrations, closely correlated with patient weight (R(2) = 0.66, p = 0.034), varied broadly (55 ± 12 to 733 ± 164 µg/mL). Pharmacokinetic modeling showed that the elimination half-life varied greatly, with an increase from 7.8 d in a patient weighing 100 kg to 19.5 d in a 40 kg patient. We predicted that infusions of 1200 mg could be spaced every 4 or 6 weeks in patients weighing <90 and <70 kg, respectively. In this pilot study, the current recommended use of a fixed eculizumab dose for maintenance therapy is associated with excessively high trough concentrations in many patients. Further prospective larger studies are now required to support an individualized schedule adjusted for patient weight and based on the observed trough serum eculizumab concentration.

Therapeutic drug monitoring of eculizumab: Rationale for an individualized dosing schedule

PubMed Central

Gatault, Philippe; Brachet, Guillaume; Ternant, David; Degenne, Danielle; Récipon, Guillaume; Barbet, Christelle; Gyan, Emmanuel; Gouilleux-Gruart, Valérie; Bordes, Cécile; Farrell, Alexandra; Halimi, Jean Michel; Watier, Hervé

2015-01-01

The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic–uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding of eculizumab pharmacokinetics and subsequent individual dose adjustment could reduce this cost. We measured the trough eculizumab concentration in 9 patients with maintenance therapy (aHUS, n = 7; PNH, n = 2) and determined: 1) the intra- and inter-individual variability; 2) the influence of weight on eculizumab pharmacokinetics; and 3) the rate of elimination of eculizumab following discontinuation. A one-compartment model was developed to describe the pharmacokinetics of eculizumab and predicted complement activity by body weight. Trough eculizumab concentrations were >50 µg/mL in 9/9, >100 µg/mL in 8/9, and >300 µg/mL in 5/9 of patients. Intra-individual variability was low but eculizumab concentrations, closely correlated with patient weight (R2 = 0.66, p = 0.034), varied broadly (55 ± 12 to 733 ± 164 µg/mL). Pharmacokinetic modeling showed that the elimination half-life varied greatly, with an increase from 7.8 d in a patient weighing 100 kg to 19.5 d in a 40 kg patient. We predicted that infusions of 1200 mg could be spaced every 4 or 6 weeks in patients weighing <90 and <70 kg, respectively. In this pilot study, the current recommended use of a fixed eculizumab dose for maintenance therapy is associated with excessively high trough concentrations in many patients. Further prospective larger studies are now required to support an individualized schedule adjusted for patient weight and based on the observed trough serum eculizumab concentration. PMID:26337866

Spatial and temporal distribution of pore gas concentrations during mainstream large-scale trough composting in China.

PubMed

Zeng, Jianfei; Shen, Xiuli; Sun, Xiaoxi; Liu, Ning; Han, Lujia; Huang, Guangqun

2018-05-01

With the advantages of high treatment capacity and low operational cost, large-scale trough composting has become one of the mainstream composting patterns in composting plants in China. This study measured concentrations of O 2 , CO 2 , CH 4 and NH 3 on-site to investigate the spatial and temporal distribution of pore gas concentrations during mainstream large-scale trough composting in China. The results showed that the temperature in the center of the pile was obviously higher than that in the side of the pile. Pore O 2 concentration rapidly decreased and maintained <5% (in volume) for 38 days or more in both the center and side of the pile and effective O 2 diffusion occurred at most in every two contiguous layers. Pore CO 2 and CH 4 concentrations at each measurement point were positively correlated (0.436 ≤ r ≤ 0.570, P < 0.01) and the concentrations in the side of the pile were obviously lower than those in the center. The top layer exhibited highest pore O 2 concentration and lowest CO 2 and CH 4 concentrations, and the bottom layer was on the contrary. No significant differences in pore NH 3 concentrations between different layers or between different measurement points in the same layer were found. Therefore, mixing the center and the side of the pile when mechanical turning and adjusting the height of the pile according to the physical properties of bulking agents are suggested to optimize the oxygen distribution and promote the composting process during large-scale trough composting when the pile was naturally aerated, which will contribute to improving the current undesirable atmosphere environment in China. Copyright © 2018 Elsevier Ltd. All rights reserved.

Multi-Scale Peak and Trough Detection Optimised for Periodic and Quasi-Periodic Neuroscience Data.

PubMed

Bishop, Steven M; Ercole, Ari

2018-01-01

The reliable detection of peaks and troughs in physiological signals is essential to many investigative techniques in medicine and computational biology. Analysis of the intracranial pressure (ICP) waveform is a particular challenge due to multi-scale features, a changing morphology over time and signal-to-noise limitations. Here we present an efficient peak and trough detection algorithm that extends the scalogram approach of Scholkmann et al., and results in greatly improved algorithm runtime performance. Our improved algorithm (modified Scholkmann) was developed and analysed in MATLAB R2015b. Synthesised waveforms (periodic, quasi-periodic and chirp sinusoids) were degraded with white Gaussian noise to achieve signal-to-noise ratios down to 5 dB and were used to compare the performance of the original Scholkmann and modified Scholkmann algorithms. The modified Scholkmann algorithm has false-positive (0%) and false-negative (0%) detection rates identical to the original Scholkmann when applied to our test suite. Actual compute time for a 200-run Monte Carlo simulation over a multicomponent noisy test signal was 40.96 ± 0.020 s (mean ± 95%CI) for the original Scholkmann and 1.81 ± 0.003 s (mean ± 95%CI) for the modified Scholkmann, demonstrating the expected improvement in runtime complexity from [Formula: see text] to [Formula: see text]. The accurate interpretation of waveform data to identify peaks and troughs is crucial in signal parameterisation, feature extraction and waveform identification tasks. Modification of a standard scalogram technique has produced a robust algorithm with linear computational complexity that is particularly suited to the challenges presented by large, noisy physiological datasets. The algorithm is optimised through a single parameter and can identify sub-waveform features with minimal additional overhead, and is easily adapted to run in real time on commodity hardware.

Numerical experiment on tsunami deposit distribution process by using tsunami sediment transport model in historical tsunami event of megathrust Nankai trough earthquake

NASA Astrophysics Data System (ADS)

Imai, K.; Sugawara, D.; Takahashi, T.

2017-12-01

A large flow caused by tsunami transports sediments from beach and forms tsunami deposits in land and coastal lakes. A tsunami deposit has been found in their undisturbed on coastal lakes especially. Okamura & Matsuoka (2012) found some tsunami deposits in the field survey of coastal lakes facing to the Nankai trough, and tsunami deposits due to the past eight Nankai Trough megathrust earthquakes they identified. The environment in coastal lakes is stably calm and suitable for tsunami deposits preservation compared to other topographical conditions such as plains. Therefore, there is a possibility that the recurrence interval of megathrust earthquakes and tsunamis will be discussed with high resolution. In addition, it has been pointed out that small events that cannot be detected in plains could be separated finely (Sawai, 2012). Various aspects of past tsunami is expected to be elucidated, in consideration of topographical conditions of coastal lakes by using the relationship between the erosion-and-sedimentation process of the lake bottom and the external force of tsunami. In this research, numerical examination based on tsunami sediment transport model (Takahashi et al., 1999) was carried out on the site Ryujin-ike pond of Ohita, Japan where tsunami deposit was identified, and deposit migration analysis was conducted on the tsunami deposit distribution process of historical Nankai Trough earthquakes. Furthermore, examination of tsunami source conditions is possibly investigated by comparison studies of the observed data and the computation of tsunami deposit distribution. It is difficult to clarify details of tsunami source from indistinct information of paleogeographical conditions. However, this result shows that it can be used as a constraint condition of the tsunami source scale by combining tsunami deposit distribution in lakes with computation data.

LCOE reduction potential of parabolic trough and solar tower CSP technology until 2025

NASA Astrophysics Data System (ADS)

Dieckmann, Simon; Dersch, Jürgen; Giuliano, Stefano; Puppe, Michael; Lüpfert, Eckhard; Hennecke, Klaus; Pitz-Paal, Robert; Taylor, Michael; Ralon, Pablo

2017-06-01

Concentrating Solar Power (CSP), with an installed capacity of 4.9 GW by 2015, is a young technology compared to other renewable power generation technologies. A limited number of plants and installed capacity in a small challenging market environment make reliable and transparent cost data for CSP difficult to obtain. The International Renewable Energy Agency (IRENA) and the DLR German Aerospace Center gathered and evaluated available cost data from various sources for this publication in order to yield transparent, reliable and up-to-date cost data for a set of reference parabolic trough and solar tower plants in the year 2015 [1]. Each component of the power plant is analyzed for future technical innovations and cost reduction potential based on current R&D activities, ongoing commercial developments and growth in market scale. The derived levelized cost of electricity (LCOE) for 2015 and 2025 are finally contrasted with published power purchase agreements (PPA) of the NOOR II+III power plants in Morocco. At 7.5% weighted average cost of capital (WACC) and 25 years economic life time, the levelized costs of electricity for plants with 7.5 (trough) respectively 9 (tower) full-load hours thermal storage capacity decrease from 14-15 -ct/kWh today to 9-10 -ct/kWh by 2025 for both technologies at direct normal irradiation of 2500 kWh/(m².a). The capacity factor increases from 41.1% to 44.6% for troughs and from 45.5% to 49.0% for towers. Financing conditions are a major cost driver and offer potential for further cost reduction with the maturity of the technology and low interest rates (6-7 - ct/kWh for 2% WACC at 2500 kWh/(m2.a) in 2025).

Tertiary sedimentary history and structure of the Valencia trough (western Mediterranean)

NASA Astrophysics Data System (ADS)

Maillard, A.; Mauffret, A.; Watts, A. B.; Torné, M.; Pascal, G.; Buhl, P.; Pinet, B.

1992-03-01

We present here main results of the Common Depth Point (CDP) data acquired during the Valsis 2 Cruise in 1988 in the Valencia trough. The profiles are tied in with industrial well data and this correlation allows the sedimentary and structural history of the region to be deduced. The Valsis Cruise seismic profiles have been supplemented by a very dense grid of industrial seismic lines and these data permit us to establish an accurate depth to basement map. The formation of the initial grabens, coeval with those of the Gulf of Lions, is related to the Early Miocene opening of the northwestern Mediterranean basin and the Barcelona graben is filled by the same sedimentary layers, including evaporites, as that of the Provençal region. Nevertheless, the Valencia-Catalan grabens have been reactivated by young extensional tectonics which could be a consequence of the convergence of Africa relative to Europe. The Valencia trough is segmented by transfer faults which trend NW-SE. These faults, which have a more accentuated structural expression than the Valencia and Catalonia grabens, may act as transform faults separating the individual Balearic Islands. The transfer faults are in strike with volcanic ridges which have been sampled during the DSDP Leg 13. The dense seismic grid allows us to delineate several widespread volcanic features in the Valencia trough which have been active from the Early Miocene to the Pleistocene. However, we note that the volcanic features are mainly Miocene in age whereas the recent volcanism is restricted to a narrow zone (Columbretes Islands). The compressional tectonics which deformed the Balearic Islands does not appear to extend far towards the North. We delineate the compressional front north of Ibiza, but we failed to determine any thrust or fold north of Mallorca, whereas an extensional tectonics is evident.

Offshore Tectonics of the St. Elias Mountains: Insights from Ocean Drilling and Seismic Stratigraphy on the Yakutat Shelf

NASA Astrophysics Data System (ADS)

Worthington, L. L.; Gulick, S. P. S.; Montelli, A.; Jaeger, J. M.; Zellers, S.; Walczak, M. H.; Mix, A. C.

2015-12-01

Ongoing collision of the Yakutat (YAK) microplate with North America (NA) in southern Alaska has driven orogenesis of the St. Elias Mountains and the advance of the offshore deformation front to the southeast. The offshore St. Elias fold-thrust belt records the complex interaction between collisional tectonics and glacial climate variability, providing insight for models of orogenesis and the evolution of glacial depocenters. Glacial erosion and deposition have provided sediment that constructed the upper continental shelf, much of which has been reincorporated into the orogenic wedge through offshore faulting and folding. We integrate core and downhole logging data from IODP Expedition 341 (Sites U1420 and U1421) drilled on the Yakutat shelf and slope with high-resolution and regional seismic profiles to investigate the coupled structural and stratigraphic evolution of the St. Elias margin. Site U1420 lies on the Yakutat shelf within the Bering Trough, a shelf-crossing trough that is within primary depocenter for Bering Glacier sediments. Two faults underlie the glacial packages and have been rendered inactive as the depositional environment has evolved, while faulting elsewhere on the shelf has initiated. Site U1421 lies on the current continental slope, within the backlimb of an active thrust that forms part of the modern YAK-NA deformation front. At each of these sites, we recovered glacigenic diamict (at depths up to ~1015 m at Site U1420), much of which is younger than 0.3 Ma. Age models within the trough indicated that initiation of active deformation away from the Bering Trough depocenter likely occurred since 0.3 Ma, suggesting that possible tectonic reorganization due to mass redistribution by glacial processes can occur at time scales on the order of 100kyr-1Myr.

Ramp sedimentation in the Dinantian limestones of the Shannon Trough, Co. Limerick, Ireland

NASA Astrophysics Data System (ADS)

Somerville, Ian D.; Strogen, Peter

1992-08-01

During the late Chadian and Arundian (Lower Carboniferous), an extensive carbonate ramp (Limerick Ramp) developed over County Limerick, southwest Ireland, dipping northwestwards. Three distinct facies can be recognised corresponding to position on this ramp: inner, mid- and outer ramp. The inner ramp facies of oolitic and crinoidal grainstones (Herbertstown Limestone Formation) in east Limerick formed a major shoal behind which peritidal limestones were deposited. The mid-ramp facies of muddy bioclastic limestones and shales (Cooperhill facies) in north Limerick formed between fairweather and storm wave bases. The outer ramp (basinal) facies of mudstones and thin graded resedimented limestones (Rathkeale Beds) in west Limerick developed below storm wave base when fine terrigenous input was high. Later in the Arundian there was progradation of the nearshore oolitic and crinoidal grainstones over the mid-ramp facies. By the Holkerian, the deep-water basinal facies in west Limerick was buried beneath mid-ramp facies (Durnish Limestone). The initiation of the Limerick Ramp is closely related to the formation of the Shannon Trough. In the late Courceyan, accelerated subsidence in the Shannon area during deposition of Waulsortian facies marked the onset of a sag phase. Following a quiescent period in early Chadian, subsidence was renewed in the late Chadian and Arundian, when major facies changes occurred on the ramp. Comparison of the Shannon Trough with the Dublin Basin shows that in the latter, tectonic events in the Chadian and Arundian, particularly syn-sedimentary faulting, created a sharp division between platform and basinal sedimentation. Such tectonic influence is not recognised in the Shannon Trough. Here differential subsidence and eustatic sea-level changes led to more permanent ramp existence, modified only by westwards progradation.

Is Blood Eosinophil Count a Predictor of Response to Bronchodilators in Chronic Obstructive Pulmonary Disease? Results from Post Hoc Subgroup Analyses.

PubMed

Iqbal, Ahmar; Barnes, Neil C; Brooks, Jean

2015-10-01

Chronic obstructive pulmonary disease (COPD) patients with blood eosinophil (EOS) count ≥ 2% benefit from exacerbation reductions with inhaled corticosteroids (ICSs). We conducted post hoc analyses to determine if EOS count ≥ 2% is a marker for greater responsiveness to the bronchodilators umeclidinium (UMEC; long-acting muscarinic antagonist), vilanterol (VI; long-acting β2-agonist) or UMEC/VI combination. Effects of once-daily UMEC/VI 62.5/25, UMEC 62.5 and VI 25 µg versus placebo on trough forced expiratory volume in one second (FEV1), Transition Dyspnoea Index (TDI), St George's Respiratory Questionnaire (SGRQ) scores and adverse event (AE) incidences in four completed, 6-month studies were assessed by EOS subgroup. Trough FEV1 was also evaluated by ICS use and EOS subgroup. Analyses were performed using a repeated measures model. At baseline, 2437 of 4647 (52%) patients had EOS count ≥ 2%. Overall, ≈ 50% of patients used ICSs. At day 169, no notable variations were observed in trough FEV1 least squares mean differences between EOS subgroups versus placebo for UMEC/VI, UMEC and VI; results according to ICS use were similar. No differences were reported between EOS subgroups in TDI and SGRQ scores on day 168, or for incidences of AEs, serious AEs and AEs leading to withdrawal. Response to UMEC/VI, UMEC and VI in terms of trough FEV1, dyspnoea and health-related quality of life was similar for COPD patients with baseline EOS counts ≥ 2 or <2%. EOS count did not appear to predict bronchodilator response in either ICS users or non-users.

Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China.

PubMed

Dong, Mo-Han; Wang, Jing-Wen; Wu, Yin; Chen, Bei-Yu; Yu, Min; Wen, Ai-Dong

2015-08-01

To identify specific risk factors of vancomycin-induced nephrotoxicity in China, as the relationship between vancomycin therapy (dosing and trough concentration monitoring) and nephrotoxicity has been the subject of critical debate. The cases of 90 critically ill patients who received vancomycin therapy in Xijing Hospital in the northwest of China between March 2014 and January 2015 were reviewed retrospectively. Vancomycin dosing, blood serum trough concentration, and other independent risk factors associated with nephrotoxicity were evaluated in a multivariable model. Among the 90 critically ill patients, 59 were males; mean age was 46.3 years. The indications for vancomycin use were methicillin-resistant Staphylococcus aureus-associated pneumonia, central nervous system infection, and bacteremia. Clinical pharmacists prescribed weight-based dosing, ranging from 20 to 45mg/kg/day. Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from a mean (standard deviation) of 90.0 (18.8) μmol/l to 133.8 (63.2) μmol/l (p = 0.015). It was found that those with a vancomycin dosage >38mg/kg/day (50.0% vs. 11.3%, p = 0.004) and a vancomycin serum trough concentration >20mg/l (57.1% vs. 12.0%, p = 0.01) were more likely to develop nephrotoxicity. The data from this study indicate that a vancomycin dosage >38mg/kg/day and a serum trough level >20mg/l are both independent factors associated with the development of nephrotoxicity, suggesting that renal function should be monitored closely during vancomycin treatment. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Everolimus with reduced-dose cyclosporine in de novo renal transplant recipients: Philippine experience.

PubMed

Li, J T; Danguilan, R A; Cabanayan-Casasola, C B; Talusan-Tomacruz, Y; Ona, E T

2008-09-01

The objective of this study was to describe the appropriate dose of everolimus to achieve target trough concentrations in standard-risk Filipino kidney transplant recipients. We reviewed all kidney transplant recipients from December 1, 2006 to June 15, 2007 who were given everolimus (1.5 mg/d) in combination with low-dose cyclosporine (5 mg/kg/d) and prednisone but without induction therapy for their immunosuppressive doses, trough levels, as well as hematologic and blood chemistry profiles. Target everolimus trough concentration was 3-8 ng/mL and C2 level was 1000-1400 ng/mL for the first 3 months. Among 148 patients who underwent transplantation during the study period, 26 comprised the study population but only 15 patients completed the 3-month follow-up and are the subject of this report. Their mean age was 33 years, average PRA 2%, and mean HLA mismatches 3. All were from living donors. At 7 days posttransplantation, all patients achieved or exceeded the target everolimus trough and cyclosporine C2 level. At 1 and 3 months posttransplantation the mean everolimus dose was 1.17 and 0.78 mg/d, respectively, whereas the cyclosporine dose was 195 and 148 mg/d, respectively. Three patients showed elevated alanine aminotransferase (ALT) and all patients had hypercholesterolemia after 1 month, which improved with everolimus dose reduction (half required statins). One patient experienced a Banff Grade IA acute rejection episode at 2 months posttransplantation with a serum creatinine value of 2 mg/dL after steroid pulsing. Most standard-risk Filipino kidney transplant recipients required a maintenance everolimus dose of 1 mg/d at 1 month. The cyclosporine dose requirement was also lower. A larger sample size is needed to provide a level of significance compared with other populations.

Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: lessons from the DALI Study.

PubMed

Roberts, J A; Stove, V; De Waele, J J; Sipinkoski, B; McWhinney, B; Ungerer, J P J; Akova, M; Bassetti, M; Dimopoulos, G; Kaukonen, K-M; Koulenti, D; Martin, C; Montravers, P; Rello, J; Rhodes, A; Starr, T; Wallis, S C; Lipman, J

2014-05-01

The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The following are the median (interquartile range) total and free concentrations (mg/L): midpoint, total 13.6 (11.2-26.0) and free 1.5 (0.7-2.5); trough, total 11.9 (10.2-22.7) and free 1.8 (0.6-2.6). The percentage free teicoplanin for the mid-dose and trough time points was 6.9% (4.5-15.6%) and 8.2% (5.5-16.4%), respectively. The correlation between total and free antibiotic concentrations was moderate for both the midpoint (ρ = 0.79, P = 0.0021) and trough (ρ = 0.63, P = 0.027). Only 42% and 58% of patients were in the lower and higher therapeutic ranges, respectively. In conclusion, use of standard dosing for teicoplanin leads to inappropriate concentrations in a high proportion of critically ill patients. Variability in teicoplanin protein binding is very high, placing significant doubt on the validity of total concentrations for therapeutic drug monitoring in critically ill patients. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients.

PubMed

Chen, W-Y; Lee, C-Y; Lin, P-Y; Hsieh, C-E; Ko, C-J; Lin, K-H; Lin, C-C; Ming, Y-Z; Chen, Y-L

2017-03-01

Studies have shown that arecoline, the major alkaloid component of betel nuts, alters the activity of enzymes in the cytochrome P450 (CYP-450) family. Tacrolimus, an immunosuppressant that protects against organ rejection in transplant recipients, not only is mainly metabolized by CYP3A enzymes but also has a narrow therapeutic range. We aimed to investigate whether dose-adjusted blood trough levels of tacrolimus differed over time between betel nut-chewing and non-betel nut-chewing liver transplant recipients. In this retrospective case-control study, 14 active betel nut-using liver recipients were matched at a 1:2 ratio to 28 non-betel nut-using liver recipients by sex, age, graft source, duration of follow-up after liver transplantation, and estimated glomerular filtration rate. Differences in liver function index, renal function index, and dose-adjusted blood trough levels of tacrolimus over an 18-month period were compared between the 2 groups by using the Generalized Estimating Equation approach. Dose-adjusted blood trough levels of tacrolimus tended to be significantly (P = .04) lower in betel nut chewers (mean = 0.81, medium = 0.7, 95% confidence interval [CI] = 0.73 to 0.90) than in nonchewers (mean = 1.12, medium = 0.88, 95% CI = 1.03 to 1.22) during the 18-month study period. However, there was no significant difference in renal and liver function index between the 2 groups. Liver transplant recipients receiving tacrolimus tend to have lower blood trough levels of the drug over time if they chew betel nuts. Copyright © 2016 Elsevier Inc. All rights reserved.

Turbidite megabeds in an Oceanic Rift Valley recording jokulhlaups of late Pleistocene glacial lakes of the western United States

USGS Publications Warehouse

Zuffa, G.G.; Normark, W.R.; Serra, F.; Brunner, C.A.

2000-01-01

Escanaba Trough is the southernmost segment of the Gorda Ridge and is filled by sandy turbidites locally exceeding 500 m in thickness. New results from Ocean Drilling Program (ODP) Sites 1037 and 1038 that include accelerator mass spectrometry (AMS) 14C dates and revised petrographic evaluation of the sediment provenance, combined with high-resolution seismic-reflection profiles, provide a lithostratigraphic framework for the turbidite deposits. Three fining-upward units of sandy turbidites from the upper 365 m at ODP Site 1037 can be correlated with sediment recovered at ODP Site 1038 and Deep Sea Drilling Program (DSDP) Site 35. Six AMS 14C ages in the upper 317 m of the sequence at Site 1037 indicate that average deposition rates exceeded 10 m/k.yr. between 32 and 11 ka, with nearly instantaneous deposition of one ~60-m interval of sand. Petrography of the sand beds is consistent with a Columbia River source for the entire sedimentary sequence in Escanaba Trough. High-resolution acoustic stratigraphy shows that the turbidites in the upper 60 m at Site 1037 provide a characteristic sequence of key reflectors that occurs across the floor of the entire Escanaba Trough. Recent mapping of turbidite systems in the northeast Pacific Ocean suggests that the turbidity currents reached the Escanaba Trough along an 1100-km-long pathway from the Columbia River to the west flank of the Gorda Ridge. The age of the upper fining-upward unit of sandy turbidites appears to correspond to the latest Wisconsinan outburst of glacial Lake Missoula. Many of the outbursts, or jokulhlaups, from the glacial lakes probably continued flowing as hyperpycnally generated turbidity currents on entering the sea at the mouth of the Columbia River.

New simple spectrophotometric method for determination of the binary mixtures (atorvastatin calcium and ezetimibe; candesartan cilexetil and hydrochlorothiazide) in tablets.

PubMed

Belal, Tarek S; Daabees, Hoda G; Abdel-Khalek, Magdi M; Mahrous, Mohamed S; Khamis, Mona M

2013-04-01

A new simple spectrophotometric method was developed for the determination of binary mixtures without prior separation. The method is based on the generation of ratio spectra of compound X by using a standard spectrum of compound Y as a divisor. The peak to trough amplitudes between two selected wavelengths in the ratio spectra are proportional to concentration of X without interference from Y . The method was demonstrated by determination of two drug combinations. The first consists of the two antihyperlipidemics: atorvastatin calcium (ATV) and ezetimibe (EZE), and the second comprises the antihypertensives: candesartan cilexetil (CAN) and hydrochlorothiazide (HCT). For mixture 1, ATV was determined using 10 μg/mL EZE as the divisor to generate the ratio spectra, and the peak to trough amplitudes between 231 and 276 nm were plotted against ATV concentration. Similarly, by using 10 μg/mL ATV as divisor, the peak to trough amplitudes between 231 and 276 nm were found proportional to EZE concentration. Calibration curves were linear in the range 2.5-40 μg/mL for both drugs. For mixture 2, divisor concentration was 7.5 μg/mL for both drugs. CAN was determined using its peak to trough amplitudes at 251 and 277 nm, while HCT was estimated using the amplitudes between 251 and 276 nm. The measured amplitudes were linearly correlated to concentration in the ranges 2.5-50 and 1-30 μg/mL for CAN and HCT, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of both drug combinations in several laboratory-prepared mixtures and commercial tablets.

New simple spectrophotometric method for determination of the binary mixtures (atorvastatin calcium and ezetimibe; candesartan cilexetil and hydrochlorothiazide) in tablets

PubMed Central

Belal, Tarek S.; Daabees, Hoda G.; Abdel-Khalek, Magdi M.; Mahrous, Mohamed S.; Khamis, Mona M.

2012-01-01

A new simple spectrophotometric method was developed for the determination of binary mixtures without prior separation. The method is based on the generation of ratio spectra of compound X by using a standard spectrum of compound Y as a divisor. The peak to trough amplitudes between two selected wavelengths in the ratio spectra are proportional to concentration of X without interference from Y. The method was demonstrated by determination of two drug combinations. The first consists of the two antihyperlipidemics: atorvastatin calcium (ATV) and ezetimibe (EZE), and the second comprises the antihypertensives: candesartan cilexetil (CAN) and hydrochlorothiazide (HCT). For mixture 1, ATV was determined using 10 μg/mL EZE as the divisor to generate the ratio spectra, and the peak to trough amplitudes between 231 and 276 nm were plotted against ATV concentration. Similarly, by using 10 μg/mL ATV as divisor, the peak to trough amplitudes between 231 and 276 nm were found proportional to EZE concentration. Calibration curves were linear in the range 2.5–40 μg/mL for both drugs. For mixture 2, divisor concentration was 7.5 μg/mL for both drugs. CAN was determined using its peak to trough amplitudes at 251 and 277 nm, while HCT was estimated using the amplitudes between 251 and 276 nm. The measured amplitudes were linearly correlated to concentration in the ranges 2.5–50 and 1–30 μg/mL for CAN and HCT, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of both drug combinations in several laboratory-prepared mixtures and commercial tablets. PMID:29403805

Suitability of feeding and chewing time for estimation of feed intake in dairy cows.

PubMed

Pahl, C; Hartung, E; Grothmann, A; Mahlkow-Nerge, K; Haeussermann, A

2016-09-01

Monitoring of feeding and rumination behaviour can provide useful information for dairy herd management. The feeding behaviour of dairy cows can be recorded by different techniques, such as video cameras, weighing troughs or chewing sensors. Among feeding characteristics, individual feed intake of cows is of utmost interest, but as weighing troughs have high space and cost requirements they are used primarily in research studies. The objective of the present study was to evaluate whether records on feeding time or chewing activity or a combination of both contain enough information to estimate feed intake with sufficient accuracy. Feed intake and feeding time per cow were recorded by means of weighing troughs. Concurrently, chewing activity of seven cows was recorded by MSR-ART pressure sensors during five to eight measuring days per cow. Feeding and chewing behaviour were evaluated in time slots (1 min) and additionally assigned to feeding bouts for further analysis. The 1 min time slots were classified into feeding/no feeding or chewing/no chewing by the two systems, and agreement was found in 92.2% of the records. On average, cows spent 270±39 min/day at the feeding troughs and chewed 262±48 min/day. The average fresh matter intake (FMI) was 49.6±5.1 kg/day. Feed intake was divided into 9.7 bouts/day during which cows fed in average 27.8±21.7 min/bout and chewed 27.0±23.1 min/bout. The correlation between FMI and feeding time was r=0.891 and between FMI and chewing time r=0.780 overall cows. Hence, both systems delivered suitable information for estimating feed intake.

Facies analysis, palaeoenvironmental reconstruction and stratigraphic development of the Early Cretaceous sediments (Lower Bima Member) in the Yola Sub-basin, Northern Benue Trough, NE Nigeria

NASA Astrophysics Data System (ADS)

Sarki Yandoka, Babangida M.; Abubakar, M. B.; Abdullah, Wan Hasiah; Amir Hassan, M. H.; Adamu, Bappah U.; Jitong, John S.; Aliyu, Abdulkarim H.; Adegoke, Adebanji Kayode

2014-08-01

The Benue Trough of Nigeria is a major rift basin formed from the tension generated by the separation of African and South American plates in the Early Cretaceous. It is geographically sub-divided into Southern, Central and Northern Benue portions. The Northern Benue Trough comprises two sub-basins; the N-S trending Gongola Sub-basin and the E-W trending Yola Sub-basin. The Bima Formation is the oldest lithogenetic unit occupying the base of the Cretaceous successions in the Northern Benue Trough. It is differentiated into three members; the Lower Bima (B1), the Middle Bima (B2) and the Upper Bima (B3). Facies and their stratigraphical distribution analyses were conducted on the Lower Bima Member exposed mainly at the core of the NE-SW axially trending Lamurde Anticline in the Yola Sub-basin, with an objective to interpret the paleodepositional environments, and to reconstruct the depositional model and the stratigraphical architecture. Ten (10) lithofacies were identified on the basis of lithology, grain size, sedimentary structures and paleocurrent analysis. The facies constitute three (3) major facies associations; the gravelly dominated, the sandy dominated and the fine grain dominated. These facies and facies associations were interpreted and three facies successions were recognized; the alluvial-proximal braided river, the braided river and the lacustrine-marginal lacustrine. The stratigraphic architecture indicates a rifted (?pull-apart) origin as the facies distribution shows a progradational succession from a shallow lacustrine/marginal lacustrine (at the axial part of the basin) to alluvial fan (sediment gravity flow)-proximal braided river (gravel bed braided river) and braided river (channel and overbank) depositional systems. The facies stacking patterns depict sedimentation mainly controlled by allogenic factors of climate and tectonism.

Thermal and chemical variations of the Nigerian Benue trough lead-zinc-barite-fluorite deposits

NASA Astrophysics Data System (ADS)

Ogundipe, Ibukun Emmanuel

2017-08-01

The Benue trough is an intra-continental rift initiated in the Cretaceous during the opening of the South Atlantic Ocean. Lead-zinc-barite-fluorite mineralization occurs along the 600 km axis of the trough in three discrete sub-basins which coincide with the lower, middle and upper mineral districts of the Benue Valley. Lithologically these sub-basins are dominated by black carbonaceous shale in the Lower Benue, platform carbonates in the Middle Benue and sandstones in the Upper Benue. Micro-thermometric analysis of fluid inclusions in sphalerite, fluorite, barite and quartz have shown that each mineral district has its own unique thermal and chemical imprint. For example, the temperature can be bracketed between 109 °C and 160 °C for lower Benue, 89 °C-144 °C for the Middle Benue and 176 °C-254 °C for the Upper Benue. Chemical differentiation also exists between each mineral district with the Lower Benue having 22 wt % equivalent NaCl while the Middle and Upper Benue have 18 and 16 wt % equivalent NaCl respectively. This study shows that inter-district thermal and chemical variations exist between the ore-stage sulfide and post-sulfide gangue minerals of the entire Benue Valley. Similarly, intra-district thermal and chemical variations have also been observed among all the paragenetic minerals of each district. The thermal variations may be as a result of variations in the geothermal gradient accompanying continental rifting from one district to the other. The variations in the chemistry between the Lower Benue and the Upper Benue paragenic minerals may be as a result of the distinct lithological differences across the Benue Trough.

On purpose simulation model for molten salt CSP parabolic trough

NASA Astrophysics Data System (ADS)

Caranese, Carlo; Matino, Francesca; Maccari, Augusto

2017-06-01

The utilization of computer codes and simulation software is one of the fundamental aspects for the development of any kind of technology and, in particular, in CSP sector for researchers, energy institutions, EPC and others stakeholders. In that extent, several models for the simulation of CSP plant have been developed with different main objectives (dynamic simulation, productivity analysis, techno economic optimization, etc.), each of which has shown its own validity and suitability. Some of those models have been designed to study several plant configurations taking into account different CSP plant technologies (Parabolic trough, Linear Fresnel, Solar Tower or Dish) and different settings for the heat transfer fluid, the thermal storage systems and for the overall plant operating logic. Due to a lack of direct experience of Molten Salt Parabolic Trough (MSPT) commercial plant operation, most of the simulation tools do not foresee a suitable management of the thermal energy storage logic and of the solar field freeze protection system, but follow standard schemes. ASSALT, Ase Software for SALT csp plants, has been developed to improve MSPT plant's simulations, by exploiting the most correct operational strategies in order to provide more accurate technical and economical results. In particular, ASSALT applies MSPT specific control logics for the electric energy production and delivery strategy as well as the operation modes of the Solar Field in off-normal sunshine condition. With this approach, the estimated plant efficiency is increased and the electricity consumptions required for the plant operation and management is drastically reduced. Here we present a first comparative study on a real case 55 MWe Molten Salt Parabolic Trough CSP plant placed in the Tibetan highlands, using ASSALT and SAM (System Advisor Model), which is a commercially available simulation tool.