Linking asphalt binder fatigue to asphalt mixture fatigue performance using viscoelastic continuum damage modeling

NASA Astrophysics Data System (ADS)

Safaei, Farinaz; Castorena, Cassie; Kim, Y. Richard

2016-08-01

Fatigue cracking is a major form of distress in asphalt pavements. Asphalt binder is the weakest asphalt concrete constituent and, thus, plays a critical role in determining the fatigue resistance of pavements. Therefore, the ability to characterize and model the inherent fatigue performance of an asphalt binder is a necessary first step to design mixtures and pavements that are not susceptible to premature fatigue failure. The simplified viscoelastic continuum damage (S-VECD) model has been used successfully by researchers to predict the damage evolution in asphalt mixtures for various traffic and climatic conditions using limited uniaxial test data. In this study, the S-VECD model, developed for asphalt mixtures, is adapted for asphalt binders tested under cyclic torsion in a dynamic shear rheometer. Derivation of the model framework is presented. The model is verified by producing damage characteristic curves that are both temperature- and loading history-independent based on time sweep tests, given that the effects of plasticity and adhesion loss on the material behavior are minimal. The applicability of the S-VECD model to the accelerated loading that is inherent of the linear amplitude sweep test is demonstrated, which reveals reasonable performance predictions, but with some loss in accuracy compared to time sweep tests due to the confounding effects of nonlinearity imposed by the high strain amplitudes included in the test. The asphalt binder S-VECD model is validated through comparisons to asphalt mixture S-VECD model results derived from cyclic direct tension tests and Accelerated Loading Facility performance tests. The results demonstrate good agreement between the asphalt binder and mixture test results and pavement performance, indicating that the developed model framework is able to capture the asphalt binder's contribution to mixture fatigue and pavement fatigue cracking performance.

Research on preparation of phosphate-modified animal glue binder for foundry use

NASA Astrophysics Data System (ADS)

Wang, Tian-Shu; Liu, Wei-Hua; Li, Ying-Min

2018-03-01

In this paper, three phosphates were used as modifiers to modify animal glue binder. The structural characteristics and thermal properties of animal glue binder treated with phosphates were studied by Fourier transform-infrared spectroscopy, gel permeation chromatography and derivative thermogravimetric analysis. The results showed that the modified animal glue binder had better sand tensile strength and lower viscosity than untreated animal glue binder. The best modification process was as follows: the optimal amount of sodium carbonate was 4 wt% to animal glue; the optimal weight ratio of the modifiers was sodium pyrophosphate : sodium tripolyphosphate : sodium hexametaphosphate : animal glue = 3 : 3 : 4 : 100, and the optimal reaction should be performed at 80°C for a reaction time of 120 min. A final tensile strength of approximately 3.20 MPa was achieved and the viscosity value was approximately 880 mPa s.

Effect of Co-Production of Renewable Biomaterials on the Performance of Asphalt Binder in Macro and Micro Perspectives.

PubMed

Qu, Xin; Liu, Quan; Wang, Chao; Wang, Dawei; Oeser, Markus

2018-02-06

Conventional asphalt binder derived from the petroleum refining process is widely used in pavement engineering. However, asphalt binder is a non-renewable material. Therefore, the use of a co-production of renewable bio-oil as a modifier for petroleum asphalt has recently been getting more attention in the pavement field due to its renewability and its optimization for conventional petroleum-based asphalt binder. Significant research efforts have been done that mainly focus on the mechanical properties of bio-asphalt binder. However, there is still a lack of studies describing the effects of the co-production on performance of asphalt binders from a micro-scale perspective to better understand the fundamental modification mechanism. In this study, a reasonable molecular structure for the co-production of renewable bio-oils is created based on previous research findings and the observed functional groups from Fourier-transform infrared spectroscopy tests, which are fundamental and critical for establishing the molecular model of bio-asphalt binder with various biomaterials contents. Molecular simulation shows that the increase of biomaterial content causes the decrease of cohesion energy density, which can be related to the observed decrease of dynamic modulus. Additionally, a parameter of Flexibility Index is employed to characterize the ability of asphalt binder to resist deformation under oscillatory loading accurately.

Scaffold diversification enhances effectiveness of a superlibrary of hyperthermophilic proteins.

PubMed

Hussain, Mahmud; Gera, Nimish; Hill, Andrew B; Rao, Balaji M

2013-01-18

The use of binding proteins from non-immunoglobulin scaffolds has become increasingly common in biotechnology and medicine. Typically, binders are isolated from a combinatorial library generated by mutating a single scaffold protein. In contrast, here we generated a "superlibrary" or "library-of-libraries" of 4 × 10(8) protein variants by mutagenesis of seven different hyperthermophilic proteins; six of the seven proteins have not been used as scaffolds prior to this study. Binding proteins for five different model targets were successfully isolated from this library. Binders obtained were derived from five out of the seven scaffolds. Strikingly, binders from this modestly sized superlibrary have affinities comparable or higher than those obtained from a library with 1000-fold higher sequence diversity but derived from a single stable scaffold. Thus scaffold diversification, i.e., randomization of multiple different scaffolds, is a powerful alternate strategy for combinatorial library construction.

High performance binder-free SiO x/C composite LIB electrode made of SiO x and lignin

DOE PAGES

Chen, Tao; Hu, Jiazhi; Zhang, Long; ...

2017-07-19

A high performance binder-free SiO x/C composite electrode was synthesized by mixing SiO x particles and Kraft lignin in a cryo-mill followed by heat treatment at 600 °C. After the heat treatment, lignin formed a conductive matrix hosting SiO x particles, ensuring electronic conductivity, connectivity, and accommodation of volume changes during lithiation/delithiation. As the result, no conventional binder or conductive agent was necessary. When electrochemically cycled, the composite electrode delivered excellent performance, maintaining ~900 mAh g -1 after 250 cycles at a rate of 200 mA g -1, and good rate capability. The robustness of the electrode was also examinedmore » by post-cycling SEM images, where few cracks were observed. The excellent electrochemical performance can be attributed to the comparatively small volume change of SiO x-based electrodes (160%) and the flexibility of the lignin derived carbon matrix to accommodate the volume change. In conclusion, this work should stimulate further interests in using bio-renewable resources in making advanced electrochemical energy storage systems.« less

High performance binder-free SiO x/C composite LIB electrode made of SiO x and lignin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Tao; Hu, Jiazhi; Zhang, Long

A high performance binder-free SiO x/C composite electrode was synthesized by mixing SiO x particles and Kraft lignin in a cryo-mill followed by heat treatment at 600 °C. After the heat treatment, lignin formed a conductive matrix hosting SiO x particles, ensuring electronic conductivity, connectivity, and accommodation of volume changes during lithiation/delithiation. As the result, no conventional binder or conductive agent was necessary. When electrochemically cycled, the composite electrode delivered excellent performance, maintaining ~900 mAh g -1 after 250 cycles at a rate of 200 mA g -1, and good rate capability. The robustness of the electrode was also examinedmore » by post-cycling SEM images, where few cracks were observed. The excellent electrochemical performance can be attributed to the comparatively small volume change of SiO x-based electrodes (160%) and the flexibility of the lignin derived carbon matrix to accommodate the volume change. In conclusion, this work should stimulate further interests in using bio-renewable resources in making advanced electrochemical energy storage systems.« less

Effect of binder liquid type on spherical crystallization.

PubMed

Maghsoodi, Maryam; Hajipour, Ali

2014-11-01

Spherical crystallization is a process of formation of agglomerates of crystals held together by binder liquid. This research focused on understanding the effect of type of solvents used as binder liquid on the agglomeration of crystals. Carbamazepine and ethanol/water were used respectively as a model drug and crystallization system. Eight solvents as binder liquid including chloroform, dichloromethane, isopropyl acetate, ethyl acetate, n-hexane, dimethyl aniline, benzene and toluene were examined to better understand the relationship between the physical properties of the binder liquid and its ability to bring about the formation of the agglomerates. Moreover, the agglomerates obtained from effective solvents as binder liquid were evaluated in term of size, apparent particle density and compressive strength. In this study the clear trend was observed experimentally in the agglomerate formation as a function of physical properties of the binder liquid such as miscibility with crystallization system. Furthermore, the properties of obtained agglomerates such as size, apparent particle density and compressive strength were directly related to physical properties of effective binder liquids. RESULTS of this study offer a useful starting point for a conceptual framework to guide the selection of solvent systems for spherical crystallization.

Effect of Co-Production of Renewable Biomaterials on the Performance of Asphalt Binder in Macro and Micro Perspectives

PubMed Central

Qu, Xin; Liu, Quan; Wang, Chao; Oeser, Markus

2018-01-01

Conventional asphalt binder derived from the petroleum refining process is widely used in pavement engineering. However, asphalt binder is a non-renewable material. Therefore, the use of a co-production of renewable bio-oil as a modifier for petroleum asphalt has recently been getting more attention in the pavement field due to its renewability and its optimization for conventional petroleum-based asphalt binder. Significant research efforts have been done that mainly focus on the mechanical properties of bio-asphalt binder. However, there is still a lack of studies describing the effects of the co-production on performance of asphalt binders from a micro-scale perspective to better understand the fundamental modification mechanism. In this study, a reasonable molecular structure for the co-production of renewable bio-oils is created based on previous research findings and the observed functional groups from Fourier-transform infrared spectroscopy tests, which are fundamental and critical for establishing the molecular model of bio-asphalt binder with various biomaterials contents. Molecular simulation shows that the increase of biomaterial content causes the decrease of cohesion energy density, which can be related to the observed decrease of dynamic modulus. Additionally, a parameter of Flexibility Index is employed to characterize the ability of asphalt binder to resist deformation under oscillatory loading accurately. PMID:29415421

Binder enhanced refuse derived fuel

DOEpatents

Daugherty, Kenneth E.; Venables, Barney J.; Ohlsson, Oscar O.

1996-01-01

A refuse derived fuel (RDF) pellet having about 11% or more particulate calcium hydroxide which is utilized in a combustionable mixture. The pellets are used in a particulate fuel bring a mixture of 10% or more, on a heat equivalent basis, of the RDF pellet which contains calcium hydroxide as a binder, with 50% or more, on a heat equivalent basis, of a sulphur containing coal. Combustion of the mixture is effective to produce an effluent gas from the combustion zone having a reduced SO.sub.2 and polycyclic aromatic hydrocarbon content of effluent gas from similar combustion materials not containing the calcium hydroxide.

A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity.

PubMed

Timmerman, Peter; Barderas, Rodrigo; Desmet, Johan; Altschuh, Danièle; Shochat, Susana; Hollestelle, Martine J; Höppener, Jo W M; Monasterio, Alberto; Casal, J Ignacio; Meloen, Rob H

2009-12-04

The great success of therapeutic monoclonal antibodies has fueled research toward mimicry of their binding sites and the development of new strategies for peptide-based mimetics production. Here, we describe a new combinatorial approach for the production of peptidomimetics using the complementarity-determining regions (CDRs) from gastrin17 (pyroEGPWLEEEEEAYGWMDF-NH(2)) antibodies as starting material for cyclic peptide synthesis in a microarray format. Gastrin17 is a trophic factor in gastrointestinal tumors, including pancreatic cancer, which makes it an interesting target for development of therapeutic antibodies. Screening of microarrays containing bicyclic peptidomimetics identified a high number of gastrin binders. A strong correlation was observed between gastrin binding and overall charge of the peptidomimetic. Most of the best gastrin binders proceeded from CDRs containing charged residues. In contrast, CDRs from high affinity antibodies containing mostly neutral residues failed to yield good binders. Our experiments revealed essential differences in the mode of antigen binding between CDR-derived peptidomimetics (K(d) values in micromolar range) and the parental monoclonal antibodies (K(d) values in nanomolar range). However, chemically derived peptidomimetics from gastrin binders were very effective in gastrin neutralization studies using cell-based assays, yielding a neutralizing activity in pancreatic tumoral cell lines comparable with that of gastrin-specific monoclonal antibodies. These data support the use of combinatorial CDR-peptide microarrays as a tool for the development of a new generation of chemically synthesized cyclic peptidomimetics with functional activity.

A Combinatorial Approach for the Design of Complementarity-determining Region-derived Peptidomimetics with in Vitro Anti-tumoral Activity*

PubMed Central

Timmerman, Peter; Barderas, Rodrigo; Desmet, Johan; Altschuh, Danièle; Shochat, Susana; Hollestelle, Martine J.; Höppener, Jo W. M.; Monasterio, Alberto; Casal, J. Ignacio; Meloen, Rob H.

2009-01-01

The great success of therapeutic monoclonal antibodies has fueled research toward mimicry of their binding sites and the development of new strategies for peptide-based mimetics production. Here, we describe a new combinatorial approach for the production of peptidomimetics using the complementarity-determining regions (CDRs) from gastrin17 (pyroEGPWLEEEEEAYGWMDF-NH2) antibodies as starting material for cyclic peptide synthesis in a microarray format. Gastrin17 is a trophic factor in gastrointestinal tumors, including pancreatic cancer, which makes it an interesting target for development of therapeutic antibodies. Screening of microarrays containing bicyclic peptidomimetics identified a high number of gastrin binders. A strong correlation was observed between gastrin binding and overall charge of the peptidomimetic. Most of the best gastrin binders proceeded from CDRs containing charged residues. In contrast, CDRs from high affinity antibodies containing mostly neutral residues failed to yield good binders. Our experiments revealed essential differences in the mode of antigen binding between CDR-derived peptidomimetics (Kd values in micromolar range) and the parental monoclonal antibodies (Kd values in nanomolar range). However, chemically derived peptidomimetics from gastrin binders were very effective in gastrin neutralization studies using cell-based assays, yielding a neutralizing activity in pancreatic tumoral cell lines comparable with that of gastrin-specific monoclonal antibodies. These data support the use of combinatorial CDR-peptide microarrays as a tool for the development of a new generation of chemically synthesized cyclic peptidomimetics with functional activity. PMID:19808684

Investigation of the Effect of Oil Modification on Critical Characteristics of Asphalt Binders

NASA Astrophysics Data System (ADS)

Golalipour, Amir

Thermally induced cracking of asphalt pavement continues to be a serious issue in cold climate regions as well as in areas which experience extreme daily temperature differentials. Low temperature cracking of asphalt pavements is attributed to thermal stresses and strains developed during cooling cycles. Improving asphalt binder low temperature fracture and stiffness properties continues to be a subject of particular concern. Therefore, significant amount of research has been focused on improving asphalt binder properties through modification. In recent years, wide ranges of oil based modifications have been introduced to improve asphalt binder performance, especially at the low service temperatures. Although, significant use of these oils is seen in practice, knowledge of the fundamental mechanisms of oil modification and their properties for achieving optimum characteristics is limited. Hence, this study focuses on better understanding of the effect of oil modifiers which would help better material selection and achieve optimum performance in terms of increasing the life span of pavements. In this study, the effect of oil modification on the rheological properties of the asphalt binder is investigated. To examine the effect of oil modification on binder characteristics, low temperature properties as well as high temperature performance of oil modified binders were evaluated. It is found that oils vary in their effects on asphalt binder performance. However, for all oils used in the study, adding an oil to binder can improve binder low temperature performance, and this result mainly attributed to the softening effect. In addition to that, a simple linear model is proposed to predict the performance grade of oil modified binder based on the properties of its constituents at high and low temperatures. Another part of this study focuses on the oil modification effect on asphalt binder thermal strain and stresses. A viscoelastic analytical procedure is combined with experimentally derived failure stress and strain envelopes to determine the controlling failure mechanism, strain tolerance or critical stress, in thermal cracking of oil modified binders. The low temperature failure results depict that oil modification has a good potential of improving the cracking resistance of asphalt binders during thermal cycles.

Selective catalytic reduction system and process using a pre-sulfated zirconia binder

DOEpatents

Sobolevskiy, Anatoly; Rossin, Joseph A.

2010-06-29

A selective catalytic reduction (SCR) process with a palladium catalyst for reducing NOx in a gas, using hydrogen as a reducing agent is provided. The process comprises contacting the gas stream with a catalyst system, the catalyst system comprising (ZrO.sub.2)SO.sub.4, palladium, and a pre-sulfated zirconia binder. The inclusion of a pre-sulfated zirconia binder substantially increases the durability of a Pd-based SCR catalyst system. A system for implementing the disclosed process is further provided.

Phosphate-bonded ceramic–wood composites : R&D project overview and invitation to participate

Treesearch

Theodore L. Laufenberg; Matt Aro

2004-01-01

We are developing chemically bonded ceramic phosphate binders for the production of biofiber-based composite materials. These binders promise to have better processing and properties than some current cement and polymer resin binder systems. The ceramic phosphate binders (termed Ceramicrete), if used in place of cement and polymers, will significantly reduce the...

Flexible and Binder-Free Hierarchical Porous Carbon Film for Supercapacitor Electrodes Derived from MOFs/CNT.

PubMed

Liu, Yazhi; Li, Gaoran; Guo, Yi; Ying, Yulong; Peng, Xinsheng

2017-04-26

Rational design of free-standing porous carbon materials with large specific surface area and high conductivity is a great need for ligh-weight suprecapacitors. Here, we report a flexible porous carbon film composed of metal-organic framework (MOF)-derived porous carbon polyhedrons and carbon nanotubes (CNTs) as binder-free supercapacitor electrode for the first time. Due to the synergistic combination of carbon polyhedrons and CNT, the obtained carbon electrode shows a specific capacitance of 381.2 F g -1 at 5 mV s -1 and 194.8 F g -1 at 2 A g -1 and outstanding cycling stability with a Coulombic effciency above 95% after 10000 cycles at 10 A g -1 . The assembled aqueous symmetrical supercapacitor exhibits an energy density of 9.1 Wh kg -1 with a power density of 3500 W kg -1 . The work opens a new way to design flexible MOF-based hierarchical porous carbon film as binder-free electrodes for high-performance energy storage devices.

Using llama derived single domain antibodies to target botulinum neurotoxins

NASA Astrophysics Data System (ADS)

Swain, Marla D.; Anderson, George P.; Bernstein, Rachael D.; Liu, Jinny L.; Goldman, Ellen R.

2010-04-01

Llama serum contains both conventional IgG as well as unique forms of antibody that contain only heavy chains where antigen binding is mediated through a single variable domain. These variable domains can be expressed recombinantly and are referred to as single domain antibodies (sdAb). SdAb are among the smallest known naturally derived antigen binding fragments, possess good solubility, thermal stability, and can refold after heat and chemical denaturation. Llamas were immunized with either BoNT A or B toxoid and phage display libraries prepared. Single domain antibodies (sdAb) that were able to detect botulinum neurotoxin (BoNT) serotypes A and B were selected from their respective libraries. Here, the binders obtained by panning the BoNT B library on either BoNT B toxoid or BoNT B complex toxoid coated plates or BoNT B toxin coupled microspheres are described. Using these panning methods, we selected for binders that showed specificity for BoNT B. Phage displayed binders were screened, moved to a protein expression vector and soluble sdAb was produced. Using a Luminex flow cytometer binders were evaluated in direct binding assays. We have exploited the unique properties of sdAb and used them as biological recognition elements in immuno-based sensors that can detect BoNT B.

Texas cracking performance prediction, simulation, and binder recommendation.

DOT National Transportation Integrated Search

2014-10-01

Recent studies show some mixes with softer binders used outside of Texas (e.g., Minnesotas Cold Weather Road Research Facility mixes) have both good rutting and cracking performance. However, the current binder performance grading (PG) system fail...

Die Starter: A New System to Manage Early Feasibility in Sheet Metal Forming

NASA Astrophysics Data System (ADS)

Narainen, Rodrigue; Porzner, Harald

2016-08-01

Die Starter, a new system developed by ESI Group, allows the user to drastically reduce the number of iterations during the early tool process feasibility. This innovative system automatically designs the first quick die face, generating binder and addendum surfaces (NURBS surfaces) by taking account the full die process. Die Starter also improves the initial die face based on feasibility criteria (avoiding splits, wrinkles) by automatically generating the geometrical modifications of the binder and addendum and the bead restraining forces with minimal material usage. This paper presents a description of the new system and the methodology of Die Starter. Some industrial examples are presented from the part geometry to final die face including automatic developed flanges, part on binder and inner binder.

Advancements in Binder Systems for Solid Freeform Fabrication

NASA Technical Reports Server (NTRS)

Cooper, Ken; Munafo, Paul (Technical Monitor)

2002-01-01

Paper will present recent developments in advanced material binder systems for solid freeform fabrication (SFF) technologies. The advantage of SFF is the capability to custom fabricate complex geometries directly from computer aided design data in layer- by-layer fashion, eliminated the need for traditional fixturing and tooling. Binders allow for the low temperature processing of 'green' structural materials, either metal, ceramic or composite, in traditional rapid prototyping machines. The greatest obstacle comes when green parts must then go through a sintering or burnout process to remove the binders and fully densify the parent material, without damaging or distorting the original part geometry. Critical issues and up-to-date assessments will be delivered on various material systems.

Evaluation of the Texas tier system for seal coat binder specification.

DOT National Transportation Integrated Search

2012-09-01

The Texas Department of Transportation (TxDOT) instituted a change in their seal coat binder specification in 2010 which allowed districts to select multiple binders within specified traffic levels or tiers for the purposes of allowing contractors to...

Rheological and thermal performance of newly developed binder systems for ceramic injection molding

NASA Astrophysics Data System (ADS)

Hausnerova, Berenika; Kasparkova, Vera; Hnatkova, Eva

2016-05-01

In a novel binder system, carnauba wax was considered to replace the synthetic backbone polymers (polyolefins) enhancing the environmental sustainability of Ceramic Injection Molding (CIM) technology. The paper presents comparison of the rheological performance and thermal behavior of the aluminum oxide CIM feedstocks based on a binder containing carnauba wax with those consisting of a commercial binder. Further, acrawax (N, N'-Ethylene Bis-stearamide) has been considered as another possible substitute of polyolefins. For both proposed substitutes there is a significant reduction in viscosity, and in case of carnauba wax based feedstock also in processing temperature, which is essential for injection molding of reactive powders. Thermal characterization comprised analyses of single neat binders, their mixtures and mixtures with aluminum oxide. The presence of powder lowered melting temperatures of all tested binders except of polyolefin. Further depression in melting point of poly(ethylene glycol) is observed in combination with polyolefin in the presence of powder, and it is related to changes in size of the crystalline domains.

Control of the rheological properties of clay nanosheet hydrogels with a guanidinium-attached calix[4]arene binder.

PubMed

Lee, Ji Ha; Kim, Chaelin; Jung, Jong Hwa

2015-10-21

A 1,3-alternate calix[4]arene derivative 1 possessing four guanidinium moieties was synthesized as a molecular binder. The clay nanosheet (CNS) hydrogels were prepared upon addition of 1 and sodium polyacrylate (ASSP), and their mechanical properties were measured by rheometry. CNS hydrogels prepared by combining calix[4]arene 1 with dispersed CNSs surrounded by ASSPs showed an enhancement of mechanical properties such as viscosity and elasticity.

Carbon Nanotube and Graphene-Based Supercapacitors: Rationale, Status, and Prospects

DTIC Science & Technology

2010-08-01

porous “activated” carbon (typically derived from coconut shells) and a binder material attached to a highly conductive current collector. Carbide...fiber-, and sugar -derived activated carbons are under development to improve upon the performance of activated carbon. Carbon electrodes are

0-6674 : improving fracture resistance measurement in asphalt binder specification with verification on asphalt mixture cracking performance.

DOT National Transportation Integrated Search

2014-08-01

The current performance grading (PG) specification for asphalt binders is based primarily on the study of unmodified asphalt binders. Over the years, experience has proven that the PG grading system, while good for ensuring overall quality, fails in ...

Biodiscovery of aluminum binding peptides

NASA Astrophysics Data System (ADS)

Adams, Bryn L.; Sarkes, Deborah A.; Finch, Amethist S.; Hurley, Margaret M.; Stratis-Cullum, Dimitra

2013-05-01

Cell surface peptide display systems are large and diverse libraries of peptides (7-15 amino acids) which are presented by a display scaffold hosted by a phage (virus), bacteria, or yeast cell. This allows the selfsustaining peptide libraries to be rapidly screened for high affinity binders to a given target of interest, and those binders quickly identified. Peptide display systems have traditionally been utilized in conjunction with organic-based targets, such as protein toxins or carbon nanotubes. However, this technology has been expanded for use with inorganic targets, such as metals, for biofabrication, hybrid material assembly and corrosion prevention. While most current peptide display systems employ viruses to host the display scaffold, we have recently shown that a bacterial host, Escherichia coli, displaying peptides in the ubiquitous, membrane protein scaffold eCPX can also provide specific peptide binders to an organic target. We have, for the first time, extended the use of this bacterial peptide display system for the biodiscovery of aluminum binding 15mer peptides. We will present the process of biopanning with macroscopic inorganic targets, binder enrichment, and binder isolation and discovery.

Nitrogen-Doped Banana Peel–Derived Porous Carbon Foam as Binder-Free Electrode for Supercapacitors

PubMed Central

Liu, Bingzhi; Zhang, Lili; Qi, Peirong; Zhu, Mingyuan; Wang, Gang; Ma, Yanqing; Guo, Xuhong; Chen, Hui; Zhang, Boya; Zhao, Zhuangzhi; Dai, Bin; Yu, Feng

2016-01-01

Nitrogen-doped banana peel–derived porous carbon foam (N-BPPCF) successfully prepared from banana peels is used as a binder-free electrode for supercapacitors. The N-BPPCF exhibits superior performance including high specific surface areas of 1357.6 m2/g, large pore volume of 0.77 cm3/g, suitable mesopore size distributions around 3.9 nm, and super hydrophilicity with nitrogen-containing functional groups. It can easily be brought into contact with an electrolyte to facilitate electron and ion diffusion. A comparative analysis on the electrochemical properties of BPPCF electrodes is also conducted under similar conditions. The N-BPPCF electrode offers high specific capacitance of 185.8 F/g at 5 mV/s and 210.6 F/g at 0.5 A/g in 6 M KOH aqueous electrolyte versus 125.5 F/g at 5 mV/s and 173.1 F/g at 0.5 A/g for the BPPCF electrode. The results indicate that the N-BPPCF is a binder-free electrode that can be used for high performance supercapacitors. PMID:28344275

Nitrogen-Doped Banana Peel-Derived Porous Carbon Foam as Binder-Free Electrode for Supercapacitors.

PubMed

Liu, Bingzhi; Zhang, Lili; Qi, Peirong; Zhu, Mingyuan; Wang, Gang; Ma, Yanqing; Guo, Xuhong; Chen, Hui; Zhang, Boya; Zhao, Zhuangzhi; Dai, Bin; Yu, Feng

2016-01-15

Nitrogen-doped banana peel-derived porous carbon foam (N-BPPCF) successfully prepared from banana peels is used as a binder-free electrode for supercapacitors. The N-BPPCF exhibits superior performance including high specific surface areas of 1357.6 m²/g, large pore volume of 0.77 cm³/g, suitable mesopore size distributions around 3.9 nm, and super hydrophilicity with nitrogen-containing functional groups. It can easily be brought into contact with an electrolyte to facilitate electron and ion diffusion. A comparative analysis on the electrochemical properties of BPPCF electrodes is also conducted under similar conditions. The N-BPPCF electrode offers high specific capacitance of 185.8 F/g at 5 mV/s and 210.6 F/g at 0.5 A/g in 6 M KOH aqueous electrolyte versus 125.5 F/g at 5 mV/s and 173.1 F/g at 0.5 A/g for the BPPCF electrode. The results indicate that the N-BPPCF is a binder-free electrode that can be used for high performance supercapacitors.

Cold in-place recycling characterization framework for single or multiple component binder systems

NASA Astrophysics Data System (ADS)

Cox, Benjamin C.

Cold in-place recycling (CIR) is a pavement rehabilitation technique which has gained momentum in recent years. This momentum is due partly to its economic and sustainability characteristics, which has led to CIR market expansion. When pavement network deterioration is considered alongside increasing material costs, it is not beyond reason to expect demands on CIR to continue to increase. Historically, single component binder (SCB) systems, those with one stabilization binder (or two if the secondary binder dosage is 1% or less), have dominated the CIR market and could be considered the general state of practice. Common stabilization binders are either bituminous or cementitious. Two example SCB systems would be: 1) 3% portland cement, or 2) 3% asphalt emulsion with 1% hydrated lime. While traditional SCB systems have demonstrated positive economic and sustainability impacts, this dissertation focuses on multiple component binder (MCB) systems (bituminous and cementitious combined) which exhibit the potential to provide better overall economics and performance. Use of MCBs has the potential to alleviate SCB issues to some extent (e.g. cracking with cementitious SCBs, rutting with bituminous SCBs). Furthermore, to fairly represent both binders in an MCB system a universal design method which can accommodate multiple binder types is needed. The main objectives of this dissertation are to develop a universal CIR design framework and, using this framework, characterize multiple SCB and MCB systems. Approximately 1500 CIR specimens were tested herein along with approximately 300 asphalt concrete specimens which serve as a reference data set for CIR characterization. A case study of a high-traffic Mississippi CIR project which included cement SCB and emulsion SCB sections is also presented to support laboratory efforts. Individual components needed to comprise a universal design framework, such as curing protocols, were developed. SCB and MCB characterization indicated that cement SCBs yielded low cracking resistance, high rutting resistance, and lower costs. Emulsion SCBs yielded the opposite. MCBs demonstrated the ability to balance rutting, cracking, and economics. Overall, the universal framework presented appears promising as it could offer agencies flexibility and, in some cases, improved overall performance beyond that of current SCB design methods.

Effect of Carbon and Binder on High Sulfur Loading Electrode for Li-S Battery Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Ke; Cama, Christina A.; Huang, Jian

For the Lithium-Sulfur (Li-S) battery to be competitive in commercialization, it is requested that the sulfur electrode must have deliverable areal capacity > 8 mAh cm -2, which corresponds to a sulfur loading > 6 mg cm -2. At this relatively high sulfur loading, we evaluated the impact of binder and carbon type on the mechanical integrity and the electrochemical properties of sulfur electrodes. We identified hydroxypropyl cellulose (HPC) as a new binder for the sulfur electrode because it offers better adhesion between the electrode and the aluminum current collector than the commonly used polyvinylidene fluoride (PVDF) binder. In combinationmore » with the binder study, multiple types of carbon with high specific surface area were evaluated as sulfur hosts for high loading sulfur electrodes. A commercial microporous carbon derived from wood with high pore volume showed the best performance. An electrode with sulfur loading up to 10 mg cm -2 was achieved with the optimized recipe. Based on systematic electrochemical studies, the soluble polysulfide to insoluble Li 2S 2/Li 2S conversion was identified to be the major barrier for high loading sulfur electrodes to achieve high sulfur utilization.« less

Effect of Carbon and Binder on High Sulfur Loading Electrode for Li-S Battery Technology

DOE PAGES

Sun, Ke; Cama, Christina A.; Huang, Jian; ...

2017-03-10

For the Lithium-Sulfur (Li-S) battery to be competitive in commercialization, it is requested that the sulfur electrode must have deliverable areal capacity > 8 mAh cm -2, which corresponds to a sulfur loading > 6 mg cm -2. At this relatively high sulfur loading, we evaluated the impact of binder and carbon type on the mechanical integrity and the electrochemical properties of sulfur electrodes. We identified hydroxypropyl cellulose (HPC) as a new binder for the sulfur electrode because it offers better adhesion between the electrode and the aluminum current collector than the commonly used polyvinylidene fluoride (PVDF) binder. In combinationmore » with the binder study, multiple types of carbon with high specific surface area were evaluated as sulfur hosts for high loading sulfur electrodes. A commercial microporous carbon derived from wood with high pore volume showed the best performance. An electrode with sulfur loading up to 10 mg cm -2 was achieved with the optimized recipe. Based on systematic electrochemical studies, the soluble polysulfide to insoluble Li 2S 2/Li 2S conversion was identified to be the major barrier for high loading sulfur electrodes to achieve high sulfur utilization.« less

Fluorescence microscopy techniques for quantitative evaluation of organic biocide distribution in antifouling paint coatings: application to model antifouling coatings.

PubMed

Goodes, L R; Dennington, S P; Schuppe, H; Wharton, J A; Bakker, M; Klijnstra, J W; Stokes, K R

2012-01-01

A test matrix of antifouling (AF) coatings including pMMA, an erodible binder and a novel trityl copolymer incorporating Cu₂O and a furan derivative (FD) natural product, were subjected to pontoon immersion and accelerated rotor tests. Fluorescence and optical microscopy techniques were applied to these coatings for quantification of organic biocide and pigment distribution. Total leaching of the biocide from the novel copolymer binder was observed within 6 months of rotor immersion, compared to 35% from the pMMA coating. In pontoon immersions, 61% of the additive was lost from the pMMA coating, and 53% from the erodible binder. Profiles of FD content in the binders revealed an accelerated loss of additive from the surface of the CDP resulting from rosin degradation, compared to even depletion from pMMA. In all samples, release of the biocide was inhibited beyond the Cu₂O front, corresponding to the leached layer in samples where Cu₂O release occurred.

Sol-gel based oxidation catalyst and coating system using same

NASA Technical Reports Server (NTRS)

Leighty, Bradley D. (Inventor); Watkins, Anthony N. (Inventor); Patry, JoAnne L. (Inventor); Schryer, Jacqueline L. (Inventor); Oglesby, Donald M. (Inventor)

2010-01-01

An oxidation catalyst system is formed by particles of an oxidation catalyst dispersed in a porous sol-gel binder. The oxidation catalyst system can be applied by brush or spray painting while the sol-gel binder is in its sol state.

Unexpected DNA affinity and sequence selectivity through core rigidity in guanidinium-based minor groove binders.

PubMed

Nagle, Padraic S; McKeever, Caitriona; Rodriguez, Fernando; Nguyen, Binh; Wilson, W David; Rozas, Isabel

2014-09-25

In this paper we report the design and biophysical evaluation of novel rigid-core symmetric and asymmetric dicationic DNA binders containing 9H-fluorene and 9,10-dihydroanthracene cores as well as the synthesis of one of these fluorene derivatives. First, the affinity toward particular DNA sequences of these compounds and flexible core derivatives was evaluated by means of surface plasmon resonance and thermal denaturation experiments finding that the position of the cations significantly influence the binding strength. Then their affinity and mode of binding were further studied by performing circular dichroism and UV studies and the results obtained were rationalized by means of DFT calculations. We found that the fluorene derivatives prepared have the ability to bind to the minor groove of certain DNA sequences and intercalate to others, whereas the dihydroanthracene compounds bind via intercalation to all the DNA sequences studied here.

Nanobodies and recombinant binders in cell biology

PubMed Central

Helma, Jonas; Cardoso, M. Cristina; Muyldermans, Serge

2015-01-01

Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes. PMID:26056137

Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties.

PubMed

Monteyne, Tinne; Vancoillie, Jochem; Remon, Jean-Paul; Vervaet, Chris; De Beer, Thomas

2016-10-01

The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing requires fundamental process understanding and the implementation of quality-by-design (QbD) principles. The aim of this study was to examine the relationship between formulation-parameters (type binder, binder concentration, drug-binder miscibility), process-parameters (screw speed, powder feed rate and granulation temperature), granule properties (size, size distribution, shape, friability, true density, flowability) and tablet properties (tensile strength, friability, dissolution rate) of four different drug-binder formulations using Design of experiments (DOE). Two binders (polyethylene glycol (PEG) and Soluplus®) with a different solid state, semi-crystalline vs amorphous respectively, were combined with two model-drugs, metoprolol tartrate (MPT) and caffeine anhydrous (CAF), both having a contrasting miscibility with the binders. This research revealed that the granule properties of miscible drug-binder systems depended on the powder feed rate and barrel filling degree of the granulator whereas the granule properties of immiscible systems were mainly influenced by binder concentration. Using an amorphous binder, the tablet tensile strength depended on the granule size. In contrast, granule friability was more important for tablet quality using a brittle binder. However, this was not the case for caffeine-containing blends, since these phenomena were dominated by the enhanced compression properties of caffeine Form I, which was formed during granulation. Hence, it is important to gain knowledge about formulation behavior during processing since this influences the effect of process parameters onto the granule and tablet properties. Copyright © 2016 Elsevier B.V. All rights reserved.

Resistance to minor groove binders.

PubMed

Colmegna, Benedetta; Uboldi, Sarah; Erba, Eugenio; D'Incalci, Maurizio

2014-03-01

In this paper multiple resistance mechanisms to minor groove binders (MGBs) are overviewed. MGBs with antitumor properties are natural products or their derivatives and, as expected, they are all substrates of P-glycoprotein (P-gp). However, a moderate expression of P-gp does not appear to reduce the sensitivity to trabectedin, the only MGB so far approved for clinical use. Resistance to this drug is often related to transcriptional mechanisms and to DNA repair pathways, particularly defects in transcription-coupled nucleotide excision repair (TC-NER). Therefore tumors resistant to trabectedin may become hypersensitive to UV rays and other DNA damaging agents acting in the major groove, such as Platinum (Pt) complexes. If this is confirmed in clinic, that will provide the rationale to combine trabectedin sequentially with Pt derivates.

Influence of Mycotoxin Binders on the Oral Bioavailability of Doxycycline in Pigs.

PubMed

De Mil, Thomas; Devreese, Mathias; De Saeger, Sarah; Eeckhout, Mia; De Backer, Patrick; Croubels, Siska

2016-03-16

Mycotoxin binders are feed additives that aim to adsorb mycotoxins in the gastrointestinal tract of animals, making them unavailable for systemic absorption. The antimicrobial drug doxycycline (DOX) is often used in pigs and is administered through feed or drinking water; hence, DOX can come in contact with mycotoxin binders in the gastrointestinal tract. This paper describes the effect of four mycotoxin binders on the absorption of orally administered DOX in pigs. Two experiments were conducted: The first used a setup with bolus administration to fasted pigs at two different dosages of mycotoxin binder. In the second experiment, DOX and the binders were mixed in the feed at dosages recommended by the manufacturers (= field conditions). Interactions are possible between some of the mycotoxin binders dosed at 10 g/kg feed but not at 2 g/kg feed. When applying field conditions, no influences were seen on the plasma concentrations of DOX.

40 CFR 63.10886 - What are my management practices for binder formulations?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Area Sources Pollution Prevention Management Practices for New and Existing Affected Sources § 63.10886 What are my management practices for binder formulations? For each furfuryl alcohol warm box mold or... does not apply to the resin portion of the binder system. Requirements for New and Existing Affected...

40 CFR 63.10886 - What are my management practices for binder formulations?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Area Sources Pollution Prevention Management Practices for New and Existing Affected Sources § 63.10886 What are my management practices for binder formulations? For each furfuryl alcohol warm box mold or... does not apply to the resin portion of the binder system. Requirements for New and Existing Affected...

40 CFR 63.10886 - What are my management practices for binder formulations?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Area Sources Pollution Prevention Management Practices for New and Existing Affected Sources § 63.10886 What are my management practices for binder formulations? For each furfuryl alcohol warm box mold or... does not apply to the resin portion of the binder system. Requirements for New and Existing Affected...

40 CFR 63.10886 - What are my management practices for binder formulations?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Area Sources Pollution Prevention Management Practices for New and Existing Affected Sources § 63.10886 What are my management practices for binder formulations? For each furfuryl alcohol warm box mold or... does not apply to the resin portion of the binder system. Requirements for New and Existing Affected...

Cohesive finite element modeling of the delamination of HTPB binder and HMX crystals under tensile loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walters, David J.; Luscher, Darby J.; Yeager, John D.

Accurately modeling the mechanical behavior of the polymer binders and the degradation of interfaces between binder and crystal is important to science-based understanding of the macro-scale response of polymer bonded explosives. The paper presents a description of relatively a simple bi-crystal HMX-HTPB specimen and associated tensile loading experiment including computed tomography imaging, the pertinent constitutive theory, and details of numerical simulations used to infer the behavior of the material during the delamination process. Within this work, mechanical testing and direct numerical simulation of this relatively simple bi-crystal system enabled reasonable isolation of binder-crystal interface delamination, in which the effects ofmore » the complicated thermomechanical response of explosive crystals were minimized. Cohesive finite element modeling of the degradation and delamination of the interface between a modified HTPB binder and HMX crystals was used to reproduce observed results from tensile loading experiments on bi-crystal specimens. Several comparisons are made with experimental measurements in order to identify appropriate constitutive behavior of the binder and appropriate parameters for the cohesive traction-separation behavior of the crystal-binder interface. This research demonstrates the utility of directly modeling the delamination between binder and crystal within crystal-binder-crystal tensile specimen towards characterizing the behavior of these interfaces in a manner amenable to larger scale simulation of polycrystalline PBX materials. One critical aspect of this approach is micro computed tomography imaging conducted during the experiments, which enabled comparison of delamination patterns between the direct numerical simulation and actual specimen. In addition to optimizing the cohesive interface parameters, one important finding from this investigation is that understanding and representing the strain-hardening plasticity of HTPB binder is important within the context of using a cohesive traction-separation model for the delamination of a crystal-binder system.« less

Cohesive finite element modeling of the delamination of HTPB binder and HMX crystals under tensile loading

DOE PAGES

Walters, David J.; Luscher, Darby J.; Yeager, John D.; ...

2018-02-27

Accurately modeling the mechanical behavior of the polymer binders and the degradation of interfaces between binder and crystal is important to science-based understanding of the macro-scale response of polymer bonded explosives. The paper presents a description of relatively a simple bi-crystal HMX-HTPB specimen and associated tensile loading experiment including computed tomography imaging, the pertinent constitutive theory, and details of numerical simulations used to infer the behavior of the material during the delamination process. Within this work, mechanical testing and direct numerical simulation of this relatively simple bi-crystal system enabled reasonable isolation of binder-crystal interface delamination, in which the effects ofmore » the complicated thermomechanical response of explosive crystals were minimized. Cohesive finite element modeling of the degradation and delamination of the interface between a modified HTPB binder and HMX crystals was used to reproduce observed results from tensile loading experiments on bi-crystal specimens. Several comparisons are made with experimental measurements in order to identify appropriate constitutive behavior of the binder and appropriate parameters for the cohesive traction-separation behavior of the crystal-binder interface. This research demonstrates the utility of directly modeling the delamination between binder and crystal within crystal-binder-crystal tensile specimen towards characterizing the behavior of these interfaces in a manner amenable to larger scale simulation of polycrystalline PBX materials. One critical aspect of this approach is micro computed tomography imaging conducted during the experiments, which enabled comparison of delamination patterns between the direct numerical simulation and actual specimen. In addition to optimizing the cohesive interface parameters, one important finding from this investigation is that understanding and representing the strain-hardening plasticity of HTPB binder is important within the context of using a cohesive traction-separation model for the delamination of a crystal-binder system.« less

Binder-free nitrogen-doped carbon paper electrodes derived from polypyrrole/cellulose composite for Li-O2 batteries

NASA Astrophysics Data System (ADS)

Liu, Jia; Wang, Zhaohui; Zhu, Jiefang

2016-02-01

This work presents a novel binder-free nitrogen-doped carbon paper electrode (NCPE), which was derived from a N-rich polypyrrole (PPy)/cellulose-chopped carbon filaments (CCFs) composite, for Li-O2 batteries. The fabrication of NCPE involved cheap raw materials (e.g., Cladophora sp. green algae) and easy operation (e.g., doping N by a carbonization of N-rich polymer), which is especially suitable for large-scale production. The NCPE exhibited a bird's nest microstructure, which could provide the self-standing electrode with considerable mechanic durability, fast Li+ and O2 diffusion, and enough space for the discharge product deposition. In addition, the NCPE contained N-containing function groups, which may promote the electrochemical reactions. Furthermore, binder-free architecture designs can prevent binder-involved parasitic reactions. A Li-O2 cell with the NCPE displayed a cyclability of more than 30 cycles at a constant current density of 0.1 mA/cm2. The 1st discharge capacity for a cell with the NCPE reached 8040 mAh/g at a current density of 0.1 mA/cm2, with a cell voltage around 2.81 V. A cell with the NCPE displayed a coulombic efficiency of 81% on the 1st cycle at a current density of 0.2 mA/cm2. These results represent a promising progress in the development of a low-cost and versatile paper-based O2 electrode for Li-O2 batteries.

Natural asphalt modified binders used for high stiffness modulus asphalt concrete

NASA Astrophysics Data System (ADS)

Bilski, Marcin; Słowik, Mieczysław

2018-05-01

This paper presents a set of test results supporting the possibility of replacing, in Polish climate conditions, hard road 20/30 penetration grade bitumen used in the binder course and/or base course made of high stiffness modulus asphalt concrete with binders comprising of 35/50 or 50/70 penetration grade bitumens and additives in the form of natural Gilsonite or Trinidad Epuré asphalts. For the purpose of comparing the properties of the discussed asphalt binders, values of the Performance Grade have been determined according to the American Superpave system criteria.

Nanobodies and recombinant binders in cell biology.

PubMed

Helma, Jonas; Cardoso, M Cristina; Muyldermans, Serge; Leonhardt, Heinrich

2015-06-08

Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes. © 2015 Helma et al.

Development and Design of Binder Systems for Titanium Metal Injection Molding: An Overview

NASA Astrophysics Data System (ADS)

Wen, Guian; Cao, Peng; Gabbitas, Brian; Zhang, Deliang; Edmonds, Neil

2013-03-01

Titanium metal injection molding (Ti-MIM) has been practiced since the late 1980s. Logically, the Ti-MIM practice follows the similar processes developed for the antecedent materials such as stainless steel and ceramics. Although Ti-MIM is a favorite research topic today, the issue of convincing the designers to use Ti injection-molded parts still exists. This is mainly because of the concern about contamination which seems unavoidable during the Ti-MIM process. Much information about the binder formulation, powder requirements, debinding, and sintering is available in the literature. There are several powder vendors and feedstock suppliers. However, most of the binders in the feedstock are proprietarily protected. The disclosed information on the binders used for formulating powder feedstock is very limited, which in turn discourages their adoption by engineering designers. This overview intends to discuss some of major binder systems for Ti-MIM available in the literature. It serves to provide a guideline for the Ti-MIM practitioners to choose a suitable powder feedstock.

Recovery of fermented inulin fiber by lactic acid bacteria (LAB) from inulin hydrolysate using fungi inulinase enzymes of Scopulariopsis sp.-CBS1 and class of Deuteromycetes-CBS4 as cholesterol binder

NASA Astrophysics Data System (ADS)

Susilowati, Agustine; Melanie, Hakiki; Maryati, Yati; Aspiyanto

2017-01-01

Fermentation of Lactobacillus Acid Bacteria (LAB) which are mixtures of Lactobacillus acidophilus, Bifidobacteriumbifidum, Lactobacillus bulgaricus and Streptococcus thermophillus on hydrolysate as a result of inulin hydrolysis using inulinase enzymes obtained from endophytic fungi ofScopulariopsis sp.-CBS1 (inulin hydrolysate of S) and Class of Deuteromycetes-CBS4 (inulin hydrolysate of D) generate potential fermented inulin fiber as cholesterol binder. Fermentation process was conducted under concentrations of inulin hydrolysate 50% (w/v), LAB 15% (v/v) and skim milk 12.5% (w/v) at room temperature and 40°C for 0, 12, 24, 36 and 48 hours, respectively. Result of experimental work showed that longer time of LAB fermentation increased total acids, TPC and CBC at pH 2, but decreased total sugar, reducing, IDF, SDF, CBC pH 2 and CBC pH 7. Based on Cholesterol Binding Capacity (CBC), optimization of fermentation process on inulin hydrolysate of S was achieved by combining treatment at 40°C for 24 hours resulted in CBC pH 2 of 19.11 mg/g TDF and inulin hydrolysate of D was achieved by fermentation at 40 °C for 48 hours resulted in CBC pH 2 of 24.28 mg/g TDF. Inulin hydrolysate of class of Deutrymecetes CBS4 fermented by LAB had better functional property as cholesterol binder than that inulin hydrolysate of S fermented by LAB. This is due to cholesterol binder and cholesterol derivatives as a result of degradation of LAB on digestive system (stomach) when compared to higher colon under optimal process condition.

Influence of Binder in Iron Matrix Composites

NASA Astrophysics Data System (ADS)

Shamsuddin, S.; Jamaludin, S. B.; Hussain, Z.; Ahmad, Z. A.

2010-03-01

The ability to use iron and its alloys as the matrix material in composite systems is of great importance because it is the most widely used metallic material with a variety of commercially available steel grades [1]. The aim of this study is to investigate the influence of binder in particulate iron based metal matrix composites. There are four types of binder that were used in this study; Stearic Acid, Gummi Arabisch, Polyvinyl alcohol 15000 MW and Polyvinyl alcohol 22000 MW. Six different weight percentage of each binder was prepared to produce the composite materials using powder metallurgy (P/M) route; consists of dry mixing, uniaxially compacting at 750 MPa and vacuum sintering at 1100° C for two hours. Their characterization included a study of density, porosity, hardness and microstructure. Results indicate that MMC was affected by the binder and stearic acid as a binder produced better properties of the composite.

Characterization and Modeling of Asphalt Binder Fatigue

NASA Astrophysics Data System (ADS)

Safaei, Farinaz

Fatigue cracking is a primary distress in asphalt pavements caused by the accumulation of damage under repeated traffic loading. Many factors influence fatigue damage in pavements, including pavement structure, environmental conditions, and asphalt mixture volumetric properties. Asphalt binder is the weakest asphalt concrete constituent and, thus, plays a critical role in determining the fatigue resistance of pavements. Therefore, the ability to characterize and model the inherent fatigue performance of an asphalt binder is a necessary first step to design. A comprehensive understanding and prediction of asphalt binder fatigue performance require a suitable experiment coupled with a model to predict how the binder will perform under various traffic, temperature, and structural conditions encountered in the field. The simplified viscoelastic continuum damage (S-VECD) model has been used successfully by researchers to predict the damage evolution in asphalt mixtures for various traffic and climatic conditions using limited uniaxial test data. Although the literature shows promise for applying VECD modeling to asphalt binder fatigue, the past efforts have several shortcomings. It has been demonstrated that flow and adhesion loss can impede DSR fatigue test results. Thus, definition of test conditions (e.g., temperature) where cyclic DSR tests are appropriate for fatigue characterization of binders is necessary. In addition, the applicability of the model to predict fatigue performance under varying loading and thermal history has not been rigorously evaluated. Furthermore, the effects of material nonlinearity have been largely neglected in past modeling efforts for simplicity. In addition, past efforts have employed the parallel plate DSR geometry for the fatigue characterization of asphalt binders. In the parallel plate geometry, the strain depends on the radial distance from the specimen center. Therefore, the material will fail at different rates as a function of radial location. Past efforts have neglected the radial strain gradient, using the apparent shear stress at the sample edge to infer fatigue damage and derive S-VECD model parameters. Apparent edge stress is calculated using linear mapping to the total torque, which is erroneous in the presence of material or geometric nonlinearities (such as cracking). This study seeks to overcome the aforementioned shortcomings of past efforts to improve the ability to characterize and predict asphalt binder fatigue.

Effects of POE-g-MAH on properties of PP-based binder in metal injection molding

NASA Astrophysics Data System (ADS)

Li, Duxin; Zhang, Chenming; Ding, Chuxiong; Pan, Donghua; Lu, Renwei; Yang, Zhongchen

2018-06-01

The objective of this study is to explore the effects of maleic anhydride-grafted polyolefin elastomer (POE-g-MAH) on properties of polypropylene (PP)-based binder. The viscosity of feedstocks as well as properties of green parts, brown parts and sintered parts were investigated. Through the analysis of viscosity, the feedstock containing 8 vol% POE-g-MAH in binder was supposed to be more suitable for the injection molding. The impact absorbed energy at break increased with increasing POE-g-MAH content in binder while the bending strength decreased first and then increased. The introduction of POE-g-MAH improve the density distribution and increased the density of green parts. After debinding, most binder components were removed regardless of the POE-g-MAH content in binder. As for the parts after sintering, the carbon content decreased with an increase in POE-g-MAH content. The results suggest that POE-g-MAH act as a toughening agent as well as compatibilizer for PP-based binder/metal powder system. The mechanical properties of the green parts could be enhanced even after multiple injection and in addition the powder-binder separation trend could be decreased.

The Influence of Phosphor and Binder Chemistry on the Aging Characteristics of Remote Phosphor Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Lynn; Yaga, Robert; Lamvik, Michael

The influence of phosphor and binder layer chemistries on the lumen maintenance and color stability of remote phosphor disks were examined using wet high-temperature operational lifetime testing (WHTOL). As part of the experimental matrix, two different correlated color temperature (CCT) values, 2700 K and 5000 K, were studied and each had a different binder chemistry. The 2700 K samples used a urethane binder whereas the 5000 K samples used an acrylate binder. Experimental conditions were chosen to enable study of the binder and phosphor chemistries and to minimize photo-oxidation of the polycarbonate substrate. Under the more severe WHTOL conditions ofmore » 85°C and 85% relative humidity (RH), absorption in the binder layer significantly reduced luminous flux and produced a blue color shift. The milder WHTOL conditions of 75°C and 75% RH, resulted in chemical changes in the binder layer that may alter its index of refraction. As a result, lumen maintenance remained high, but a slight yellow shift was found. The aging of remote phosphor products provides insights into the impact of materials on the performance of phosphors in an LED lighting system.« less

Preparation of nitrogen-doped biomass-derived carbon nanofibers/graphene aerogel as a binder-free electrode for high performance supercapacitors

NASA Astrophysics Data System (ADS)

Zhang, Yimei; Wang, Fei; Zhu, Hao; Zhou, Lincheng; Zheng, Xinliang; Li, Xinghua; Chen, Zhuang; Wang, Yue; Zhang, Dandan; Pan, Duo

2017-12-01

Carbon materials derived from various biomasses have aroused forceful interest from scientific community based on their abundant resource, low cost, environment friendly and easy fabrication. Herein, the method has been developed to prepare nitrogen-doped biomass-derived carbon nanofibers/graphene aerogel (NCGA) as the binder-free electrode for supercapacitors. Ethylenediamine (EDA) is select as nitrogen source for its high nitrogen content and strong interaction with graphene oxide (GO) and cellulose nanofibers (CNFs) via hydrothermal self-assembly method to form hybrid hydrogel, and finally converts to NCGA by freeze-drying and carbonization. After carbonization the insulated CNFs converted to high conductivity carbon nanofibers. The NCGA electrode exhibits a high specific capacitance of 289 F g-1 at 5 mV s-1 and high stability of 90.5% capacitance retention ratio after 5000 cycles at 3 A g-1. This novel biomass electrode could be potential candidate for high performance supercapacitors.

Llama-derived single domain antibodies specific for Abrus agglutinin.

PubMed

Goldman, Ellen R; Anderson, George P; Zabetakis, Dan; Walper, Scott; Liu, Jinny L; Bernstein, Rachael; Calm, Alena; Carney, James P; O'Brien, Thomas W; Walker, Jennifer L; Garber, Eric A E

2011-11-01

Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid preparation. Abrin is a potent toxin similar to ricin in structure, sequence and mechanism of action. The selected sdAb were evaluated for their ability to bind to commercial abrin as well as abrax (a recombinant abrin A-chain), purified abrin fractions, Abrus agglutinin (a protein related to abrin but with lower toxicity), ricin, and unrelated proteins. Isolated sdAb were also evaluated for their ability to refold after heat denaturation and ability to be used in sandwich assays as both capture and reporter elements. The best binders were specific for the Abrus agglutinin, showing minimal binding to purified abrin fractions or unrelated proteins. These binders had sub nM affinities and regained most of their secondary structure after heating to 95 °C. They functioned well in sandwich assays. Through gel analysis and the behavior of anti-abrin monoclonal antibodies, we determined that the commercial toxoid preparation used for the original immunizations contained a high percentage of Abrus agglutinin, explaining the selection of Abrus agglutinin binders. Used in conjunction with anti-abrin monoclonal and polyclonal antibodies, these reagents can fill a role to discriminate between the highly toxic abrin and the related, but much less toxic, Abrus agglutinin and distinguish between different crude preparations.

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

PubMed Central

Goldman, Ellen R.; Anderson, George P.; Zabetakis, Dan; Walper, Scott; Liu, Jinny L.; Bernstein, Rachael; Calm, Alena; Carney, James P.; O’Brien, Thomas W.; Walker, Jennifer L.; Garber, Eric A. E.

2011-01-01

Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid preparation. Abrin is a potent toxin similar to ricin in structure, sequence and mechanism of action. The selected sdAb were evaluated for their ability to bind to commercial abrin as well as abrax (a recombinant abrin A-chain), purified abrin fractions, Abrus agglutinin (a protein related to abrin but with lower toxicity), ricin, and unrelated proteins. Isolated sdAb were also evaluated for their ability to refold after heat denaturation and ability to be used in sandwich assays as both capture and reporter elements. The best binders were specific for the Abrus agglutinin, showing minimal binding to purified abrin fractions or unrelated proteins. These binders had sub nM affinities and regained most of their secondary structure after heating to 95 °C. They functioned well in sandwich assays. Through gel analysis and the behavior of anti-abrin monoclonal antibodies, we determined that the commercial toxoid preparation used for the original immunizations contained a high percentage of Abrus agglutinin, explaining the selection of Abrus agglutinin binders. Used in conjunction with anti-abrin monoclonal and polyclonal antibodies, these reagents can fill a role to discriminate between the highly toxic abrin and the related, but much less toxic, Abrus agglutinin and distinguish between different crude preparations. PMID:22174977

Experimentally validated computational modeling of organic binder burnout from green ceramic compacts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ewsuk, K.G.; Cochran, R.J.; Blackwell, B.F.

The properties and performance of a ceramic component is determined by a combination of the materials from which it was fabricated and how it was processed. Most ceramic components are manufactured by dry pressing a powder/binder system in which the organic binder provides formability and green compact strength. A key step in this manufacturing process is the removal of the binder from the powder compact after pressing. The organic binder is typically removed by a thermal decomposition process in which heating rate, temperature, and time are the key process parameters. Empirical approaches are generally used to design the burnout time-temperaturemore » cycle, often resulting in excessive processing times and energy usage, and higher overall manufacturing costs. Ideally, binder burnout should be completed as quickly as possible without damaging the compact, while using a minimum of energy. Process and computational modeling offer one means to achieve this end. The objective of this study is to develop an experimentally validated computer model that can be used to better understand, control, and optimize binder burnout from green ceramic compacts.« less

A Robust, Water-Based, Functional Binder Framework for High-Energy Lithium-Sulfur Batteries.

PubMed

Lacey, Matthew J; Österlund, Viking; Bergfelt, Andreas; Jeschull, Fabian; Bowden, Tim; Brandell, Daniel

2017-07-10

We report here a water-based functional binder framework for the lithium-sulfur battery systems, based on the general combination of a polyether and an amide-containing polymer. These binders are applied to positive electrodes optimised towards high-energy electrochemical performance based only on commercially available materials. Electrodes with up to 4 mAh cm -2 capacity and 97-98 % coulombic efficiency are achievable in electrodes with a 65 % total sulfur content and a poly(ethylene oxide):poly(vinylpyrrolidone) (PEO:PVP) binder system. Exchange of either binder component for a different polymer with similar functionality preserves the high capacity and coulombic efficiency. The improvement in coulombic efficiency from the inclusion of the coordinating amide group was also observed in electrodes where pyrrolidone moieties were covalently grafted to the carbon black, indicating the role of this functionality in facilitating polysulfide adsorption to the electrode surface. The mechanical properties of the electrodes appear not to significantly influence sulfur utilisation or coulombic efficiency in the short term but rather determine retention of these properties over extended cycling. These results demonstrate the robustness of this very straightforward approach, as well as the considerable scope for designing binder materials with targeted properties. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

In-situ Click Reaction Coupled with Quantitative Proteomics for Identifying Protein Targets of Catechol Estrogens.

PubMed

Liang, Huei-Chen; Liu, Yi-Chen; Chen, Hsin; Ku, Ming Chun; Do, Quynh-Trang; Wang, Chih-Yen; Tzeng, Shun-Fen; Chen, Shu-Hui

2018-06-13

Catechol estrogens (CEs) are metabolic electrophiles that actively undergo covalent interaction with cellular proteins, influencing molecular function. There is no feasible method to identify their binders in a living system. Herein, we developed a click chemistry-based approach using ethinylestradiol (EE2) as the precursor probe coupled with quantitative proteomics to identify protein targets of CEs and classify their binding strengths. Using in-situ metabolic conversion and click reaction in liver microsomes, CEs-protein complex was captured by the probe, digested by trypsin, stable isotope labeled via reductive amination, and analyzed by liquid chromatography-mass spectrometry (LC-MS). A total of 334 liver proteins were repeatedly identified (n  2); 274 identified proteins were classified as strong binders based on precursor mass mapping. The binding strength was further scaled by D/H ratio (activity probe/solvent): 259 strong binders had D/H > 5.25; 46 weak binders had 5.25 > D/H > 1; 5 non-specific binders (keratins) had D/H < 1. These results were confirmed using spiked covalent control (strong binder) and noncovalent control (weak binder), as well as in vitro testing of cytochrome c (D/H = 5.9) which showed covalent conjugation with CEs. Many identified strong binders, such as glutathione transferase, catechol-O-methyl transferase, superoxide dismutase, catalase, glutathione peroxidase, and cytochrome c, are involved in cellular redox processes or detoxification activities. CE conjugation was shown to suppress the superoxide oxidase activity of cytochrome c, suggesting that CEs modification may alter the redox action of cellular proteins. Due to structural similarity and inert alkyne group, EE2 probe is very likely to capture protein targets of CEs in general. Thus, this strategy can be adopted to explore the biological impact of CEs modification in living systems.

Investigating Deformation and Mesoscale Void Creation in HMX Based Composites using Tomography Based Grain Scale Finite Element Modeling

NASA Astrophysics Data System (ADS)

Walters, David J.; Luscher, Darby J.; Manner, Virginia; Yeager, John D.; Patterson, Brian M.

2017-06-01

The microstructure of plastic bonded explosives (PBXs) significantly affects their macroscale mechanical characteristics. Imaging and modeling of the mesoscale constituents allows for a detailed examination of the deformation of mechanically loaded PBXs. In this study, explosive composites, formulated with HMX crystals and various HTPB based polymer binders have been imaged using micro Computed Tomography (μCT). Cohesive parameters for simulation of the crystal/binder interface are determined by comparing numerical and experimental results of the delamination of a polymer bound bi-crystal system. Similarly, polycrystalline samples are discretized into a finite element mesh using the mesoscale geometry captured by in-situ μCT imaging. Experimentally, increasing the stiffness of the HTPB binder in the polycrystalline system resulted in a transition from ductile flow with little crystal/binder delamination to brittle behavior with increased void creation along the interfaces. Simulating the macroscale compression of these samples demonstrates the effects that the mesoscale geometry, cohesive properties, and binder stiffness have on the creation and distribution of interfacial voids. Understanding void nucleation is critical for modeling damage in these complex materials.

Managing oral phosphate binder medication expenditures within the Medicare bundled end-stage renal disease prospective payment system: economic implications for large U.S. dialysis organizations.

PubMed

Park, Haesuk; Rascati, Karen L; Keith, Michael S

2015-06-01

From January 2016, payment for oral-only renal medications (including phosphate binders and cinacalcet) was expected to be included in the new Medicare bundled end-stage renal disease (ESRD) prospective payment system (PPS). The implementation of the ESRD PPS has generated concern within the nephrology community because of the potential for inadequate funding and the impact on patient quality of care. To estimate the potential economic impact of the new Medicare bundled ESRD PPS reimbursement from the perspective of a large dialysis organization in the United States. We developed an interactive budget impact model to evaluate the potential economic implications of Medicare payment changes to large dialysis organizations treating patients with ESRD who are receiving phosphate binders. In this analysis, we focused on the budget impact of the intended 2016 integration of oral renal drugs, specifically oral phosphate binders, into the PPS. We also utilized the model to explore the budgetary impact of a variety of potential shifts in phosphate binder market shares under the bundled PPS from 2013 to 2016. The base model predicts that phosphate binder costs will increase to $34.48 per dialysis session in 2016, with estimated U.S. total costs for phosphate binders of over $682 million. Based on these estimates, a projected Medicare PPS $33.44 reimbursement rate for coverage of all oral-only renal medications (i.e., phosphate binders and cinacalcet) would be insufficient to cover these costs. A potential renal drugs and services budget shortfall for large dialysis organizations of almost $346 million was projected. Our findings suggest that large dialysis organizations will be challenged to manage phosphate binder expenditures within the planned Medicare bundled rate structure. As a result, large dialysis organizations may have to make treatment choices in light of potential inadequate funding, which could have important implications for the quality of care for patients with ESRD.

Investigations into the burning-out of organic substances in the ceramic body

NASA Technical Reports Server (NTRS)

Locher, C.; Pfaff, E.; Schulz, P.; Zografou, C.

1983-01-01

Pressed compacts were made of spray dried alumina containing water soluble polyvinyl alcohol or cellulose derivative binder. The burning out of organic binder on gradual heating was investigated by visual and microscopic observations of the cross section and by thermogravimetry. Burning out proceeds inward from the peripheries, gradually reducing the size of the black core, which first consists of a dark boundary layer and later turns uniformly black with a sharp boundary. A detailed mechanism of the burning out process between and within the spray dried granules is observed under the microscope. Oxygen atmosphere accelerates the burning out process.

Analysis of the usage of rubberized asphalt in hot mix asphalt using Reclaimed Asphalt Pavement (RAP)

NASA Astrophysics Data System (ADS)

Dwidarma Nataadmadja, Adelia; Prahara, Eduardi; Sumbung, Pierre Christian

2017-12-01

There has been an increasing demand in using more environmentally friendly materials in pavement construction. One of the alternative materials that have been widely used is the Reclaimed Asphalt Pavement (RAP) aggregates. The RAP aggregates are derived from the crushed and screened pavement materials that contain asphalt and aggregates. This material is usually combined with natural aggregates and virgin asphalt binder to construct a new pavement. There have been numerous positive feedbacks in using this material although RAP aggregates also have certain weaknesses, such as questionable interaction between virgin and recycled materials and increased stiffness of RAP binder. Moreover, there has been a push on using rubber as an additive to asphalt binder to improve the welfare of rubber farmers. This research combines the usage of both latex and RAP as the ingredients to design hot mix asphalt (HMA) as latex could help in improving the flexibility of HMA and the interaction between the virgin and recycled materials. The main objective of this research is to find a suitable percentage of RAP aggregates to be used in HMA with certain percentage of latex as the binder additive.

Single Domain Antibodies as New Biomarker Detectors

PubMed Central

Fischer, Katja; Leow, Chiuan Yee; Chuah, Candy; McCarthy, James

2017-01-01

Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for monitoring the progression of diseases. Antibodies represent promising tools for recognition of biomarkers, and are widely deployed as analytical tools in clinical settings. For immunodiagnostics, antibodies are now exploited as binders for antigens of interest across a range of platforms. More recently, the discovery of antibody surface display and combinatorial chemistry techniques has allowed the exploration of new binders from a range of animals, for instance variable domains of new antigen receptors (VNAR) from shark and variable heavy chain domains (VHH) or nanobodies from camelids. These single domain antibodies (sdAbs) have some advantages over conventional murine immunoglobulin owing to the lack of a light chain, making them the smallest natural biomarker binders thus far identified. In this review, we will discuss several biomarkers used as a means to validate diseases progress. The potential functionality of modern singe domain antigen binders derived from phylogenetically early animals as new biomarker detectors for current diagnostic and research platforms development will be described. PMID:29039819

Black Ink of Activated Carbon Derived From Palm Kernel Cake (PKC)

NASA Astrophysics Data System (ADS)

Selamat, M. H.; Ahmad, A. H.

2009-06-01

Recycling the waste from natural plant to produce useful end products will benefit many industries and help preserve the environment. The research reported in this paper is an investigation on the use of the natural waste of palm kernel cake (PKC) to produce carbon residue as a black carbon for pigment source by using pyrolysis process. The activated carbons (AC) is produced in powder form using ball milling process. Rheological spectra in ink is one of quality control process in determining its performance properties. Findings from this study will help expand the scientific knowledge-base for black ink production and formulation base on PKC. Various inks with different weight percentage compositions of AC will be made and tested against its respective rheological properties in order to determine ideal ink printing system. The items in the formulation used comprised of organic and bio-waste materials with added additive to improve the quality of the black ink. Modified Polyurethane was used as binder. The binder's properties highlighted an ideal vehicle to be applied for good black ink opacity performance. The rheological behaviour is a general foundation for ink characterization where the wt% of AC-PKC resulted in different pseudoplastic behaviors, including the Newtonian behavior. The result found that Newtonian field was located in between 2 wt% and 10 wt% of AC-PKC composition with binder. Mass spectroscopy results shown that the carbon content in PKC is high and very suitable for black performance. In the ageing test, the pigment of PKC perform fairly according to the standard pigment of Black carbon (CB) of ferum oxide pigment. The contact angle for substrate's wettability of the ink system shown a good angle proven to be a water resistive coating on paper subtrates; an advantage of the PKC ink pigment performance.

Selection and evaluation of performance-graded asphalt binders for Virginia.

DOT National Transportation Integrated Search

1999-06-01

This study recommended performance-graded (PG) binders to be used in hot-mix asphalt in Virginia. Ten conventional viscosity-graded asphalt cements, representing the asphalt typically available in Virginia, were graded under the PG system to develop ...

Lithium metal doped electrodes for lithium-ion rechargeable chemistry

DOEpatents

Liu, Gao; Battaglia, Vince; Wang, Lei

2016-09-13

An embodiment of the invention combines the superior performance of a polyvinylidene difluoride (PVDF) or polyethyleneoxide (POE) binder, the strong binding force of a styrene-butadiene (SBR) binder, and a source of lithium ions in the form of solid lithium metal powder (SLMP) to form an electrode system that has improved performance as compared to PVDF/SBR binder based electrodes. This invention will provide a new way to achieve improved results at a much reduced cost.

In situ imaging during compression of plastic bonded explosives for damage modeling

DOE PAGES

Manner, Virginia Warren; Yeager, John David; Patterson, Brian M.; ...

2017-06-10

Here, the microstructure of plastic bonded explosives (PBXs) is known to influence behavior during mechanical deformation, but characterizing the microstructure can be challenging. For example, the explosive crystals and binder in formulations such as PBX 9501 do not have sufficient X-ray contrast to obtain three-dimensional data by in situ, absorption contrast imaging. To address this difficulty, we have formulated a series of PBXs using octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) crystals and low-density binder systems. The binders were hydroxyl-terminated polybutadiene (HTPB) or glycidyl azide polymer (GAP) cured with a commercial blend of acrylic monomers/oligomers. The binder density is approximately half of the HMX, allowingmore » for excellent contrast using in situ X-ray computed tomography (CT) imaging. The samples were imaged during unaxial compression using micro-scale CT in an interrupted in situ modality. The rigidity of the binder was observed to significantly influence fracture, crystal-binder delamination, and flow. Additionally, 2D slices from the segmented 3D images were meshed for finite element simulation of the mesoscale response. At low stiffness, the binder and crystal do not delaminate and the crystals move with the material flow; at high stiffness, marked delamination is noted between the crystals and the binder, leading to very different mechanical properties. Initial model results exhibit qualitatively similar delamination.« less

In situ imaging during compression of plastic bonded explosives for damage modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manner, Virginia Warren; Yeager, John David; Patterson, Brian M.

Here, the microstructure of plastic bonded explosives (PBXs) is known to influence behavior during mechanical deformation, but characterizing the microstructure can be challenging. For example, the explosive crystals and binder in formulations such as PBX 9501 do not have sufficient X-ray contrast to obtain three-dimensional data by in situ, absorption contrast imaging. To address this difficulty, we have formulated a series of PBXs using octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) crystals and low-density binder systems. The binders were hydroxyl-terminated polybutadiene (HTPB) or glycidyl azide polymer (GAP) cured with a commercial blend of acrylic monomers/oligomers. The binder density is approximately half of the HMX, allowingmore » for excellent contrast using in situ X-ray computed tomography (CT) imaging. The samples were imaged during unaxial compression using micro-scale CT in an interrupted in situ modality. The rigidity of the binder was observed to significantly influence fracture, crystal-binder delamination, and flow. Additionally, 2D slices from the segmented 3D images were meshed for finite element simulation of the mesoscale response. At low stiffness, the binder and crystal do not delaminate and the crystals move with the material flow; at high stiffness, marked delamination is noted between the crystals and the binder, leading to very different mechanical properties. Initial model results exhibit qualitatively similar delamination.« less

In Situ Imaging during Compression of Plastic Bonded Explosives for Damage Modeling.

PubMed

Manner, Virginia W; Yeager, John D; Patterson, Brian M; Walters, David J; Stull, Jamie A; Cordes, Nikolaus L; Luscher, Darby J; Henderson, Kevin C; Schmalzer, Andrew M; Tappan, Bryce C

2017-06-10

The microstructure of plastic bonded explosives (PBXs) is known to influence behavior during mechanical deformation, but characterizing the microstructure can be challenging. For example, the explosive crystals and binder in formulations such as PBX 9501 do not have sufficient X-ray contrast to obtain three-dimensional data by in situ, absorption contrast imaging. To address this difficulty, we have formulated a series of PBXs using octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) crystals and low-density binder systems. The binders were hydroxyl-terminated polybutadiene (HTPB) or glycidyl azide polymer (GAP) cured with a commercial blend of acrylic monomers/oligomers. The binder density is approximately half of the HMX, allowing for excellent contrast using in situ X-ray computed tomography (CT) imaging. The samples were imaged during unaxial compression using micro-scale CT in an interrupted in situ modality. The rigidity of the binder was observed to significantly influence fracture, crystal-binder delamination, and flow. Additionally, 2D slices from the segmented 3D images were meshed for finite element simulation of the mesoscale response. At low stiffness, the binder and crystal do not delaminate and the crystals move with the material flow; at high stiffness, marked delamination is noted between the crystals and the binder, leading to very different mechanical properties. Initial model results exhibit qualitatively similar delamination.

In Situ Imaging during Compression of Plastic Bonded Explosives for Damage Modeling

PubMed Central

Manner, Virginia W.; Yeager, John D.; Patterson, Brian M.; Walters, David J.; Stull, Jamie A.; Cordes, Nikolaus L.; Luscher, Darby J.; Henderson, Kevin C.; Schmalzer, Andrew M.; Tappan, Bryce C.

2017-01-01

The microstructure of plastic bonded explosives (PBXs) is known to influence behavior during mechanical deformation, but characterizing the microstructure can be challenging. For example, the explosive crystals and binder in formulations such as PBX 9501 do not have sufficient X-ray contrast to obtain three-dimensional data by in situ, absorption contrast imaging. To address this difficulty, we have formulated a series of PBXs using octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) crystals and low-density binder systems. The binders were hydroxyl-terminated polybutadiene (HTPB) or glycidyl azide polymer (GAP) cured with a commercial blend of acrylic monomers/oligomers. The binder density is approximately half of the HMX, allowing for excellent contrast using in situ X-ray computed tomography (CT) imaging. The samples were imaged during unaxial compression using micro-scale CT in an interrupted in situ modality. The rigidity of the binder was observed to significantly influence fracture, crystal-binder delamination, and flow. Additionally, 2D slices from the segmented 3D images were meshed for finite element simulation of the mesoscale response. At low stiffness, the binder and crystal do not delaminate and the crystals move with the material flow; at high stiffness, marked delamination is noted between the crystals and the binder, leading to very different mechanical properties. Initial model results exhibit qualitatively similar delamination. PMID:28772998

Hyperscaling breakdown and Ising spin glasses: The Binder cumulant

NASA Astrophysics Data System (ADS)

Lundow, P. H.; Campbell, I. A.

2018-02-01

Among the Renormalization Group Theory scaling rules relating critical exponents, there are hyperscaling rules involving the dimension of the system. It is well known that in Ising models hyperscaling breaks down above the upper critical dimension. It was shown by Schwartz (1991) that the standard Josephson hyperscaling rule can also break down in Ising systems with quenched random interactions. A related Renormalization Group Theory hyperscaling rule links the critical exponents for the normalized Binder cumulant and the correlation length in the thermodynamic limit. An appropriate scaling approach for analyzing measurements from criticality to infinite temperature is first outlined. Numerical data on the scaling of the normalized correlation length and the normalized Binder cumulant are shown for the canonical Ising ferromagnet model in dimension three where hyperscaling holds, for the Ising ferromagnet in dimension five (so above the upper critical dimension) where hyperscaling breaks down, and then for Ising spin glass models in dimension three where the quenched interactions are random. For the Ising spin glasses there is a breakdown of the normalized Binder cumulant hyperscaling relation in the thermodynamic limit regime, with a return to size independent Binder cumulant values in the finite-size scaling regime around the critical region.

A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders

PubMed Central

Cui, Naiwen; Zhang, Huidan; Schneider, Nils; Tao, Ye; Asahara, Haruichi; Sun, Zhiyi; Cai, Yamei; Koehler, Stephan A.; de Greef, Tom F. A.; Abbaspourrad, Alireza; Weitz, David A.; Chong, Shaorong

2016-01-01

Drop-based microfluidics have recently become a novel tool by providing a stable linkage between phenotype and genotype for high throughput screening. However, use of drop-based microfluidics for screening high-affinity peptide binders has not been demonstrated due to the lack of a sensitive functional assay that can detect single DNA molecules in drops. To address this sensitivity issue, we introduced in vitro two-hybrid system (IVT2H) into microfluidic drops and developed a streamlined mix-and-read drop-IVT2H method to screen a random DNA library. Drop-IVT2H was based on the correlation between the binding affinity of two interacting protein domains and transcriptional activation of a fluorescent reporter. A DNA library encoding potential peptide binders was encapsulated with IVT2H such that single DNA molecules were distributed in individual drops. We validated drop-IVT2H by screening a three-random-residue library derived from a high-affinity MDM2 inhibitor PMI. The current drop-IVT2H platform is ideally suited for affinity screening of small-to-medium-sized libraries (103–106). It can obtain hits within a single day while consuming minimal amounts of reagents. Drop-IVT2H simplifies and accelerates the drop-based microfluidics workflow for screening random DNA libraries, and represents a novel alternative method for protein engineering and in vitro directed protein evolution. PMID:26940078

Gas Retention in a Heated Plastic Bonded Explosive (LX-14).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hobbs, Michael L.; Kaneshige, Michael J.; Erikson, William W.

In prior work, we found that the nitroplasticizer in the plastic bonded explosive PBX 9501 played a crucial role in cookoff, especially when predicting response in larger systems [1]. We have recently completed experiments with a similar explosive, LX-14, that has a relatively nonreactive binder. We expected the ignition times for LX-14 to be longer than PBX 9501 since PBX 9501 has a more reactive binder. However, our experiments show the opposite trend. This paradox can be explained by retention of reactive gases within the interior of LX-14 by the higher strength binder resulting in faster ignition times. In contrast,more » the binder in PBX 9501 melts at low temperatures and does not retain decomposition gases as well as the LX-14 binder. Retention of reactive gases in LX-14 may also explain the more violent response in oblique impact tests [2] when compared to PBX 9501.« less

Semiconductor cooling apparatus

NASA Technical Reports Server (NTRS)

Banks, Bruce A. (Inventor); Gaier, James R. (Inventor)

1993-01-01

Gas derived graphite fibers generated by the decomposition of an organic gas are joined with a suitable binder. This produces a high thermal conductivity composite material which passively conducts heat from a source, such as a semiconductor, to a heat sink. The fibers may be intercalated. The intercalate can be halogen or halide salt, alkaline metal, or any other species which contributes to the electrical conductivity improvement of the graphite fiber. The fibers are bundled and joined with a suitable binder to form a high thermal conductivity composite material device. The heat transfer device may also be made of intercalated highly oriented pyrolytic graphite and machined, rather than made of fibers.

Structural comparison of Gilsonite and Trinidad Lake Asphalt using 13C-NMR technique

NASA Astrophysics Data System (ADS)

Nciri, Nader; Cho, Namjun

2017-04-01

The recent increased importance of natural asphalt as an alternative binder for sustainable road pavement has dictated that more knowledge should be acquired about its structure and properties. Earlier, Carbon-13 NMR spectroscopy has been applied to very few natural bituminous materials. In this work, two types of raw binders namely Gilsonite and Trinidad Lake asphalt (TLA) have been subjected to an extensive investigation by using 13C-NMR technique. Results have shown that valuable chemical data can be readily withdrawn on aromatic ring structures and ring substituents in natural asphalts derived from different sources. The chemical significance of these findings will be discussed.

Development of viscosity sensor with long period fiber grating technology

NASA Astrophysics Data System (ADS)

Lin, Jyh-Dong; Wang, Jian-Neng; Chen, Shih-Huang; Wang, Juei-Mao

2009-03-01

In this paper, we describe the development of a viscosity sensing system using a simple and low-cost long-period fiber grating (LPFG) sensor. The LPFG sensor was extremely sensitive to the refractive index of the medium surrounding the cladding surface of the sensing grating, thus allowing it to be used as an ambient index sensor or chemical concentration indicator. Viscosity can be simply defined as resistance to flow of a liquid. We have measured asphalt binder, 100-190000 centistokes, in comparison with optical sensing results. The system sensing asphalt binders exhibited increase trend in the resonance wavelength shift when the refractive index of the medium changed. The prototype sensor consisted of a LPFG sensing component and a cone-shaped reservoir where gravitational force can cause asphalt binders flow through the capillary. Thus the measured time for a constant volume of asphalt binders can be converted into either absolute or kinematic viscosity. In addition, a rotational viscometer and a dynamic shear rheometer were also used to evaluate the viscosity of this liquid, the ratio between the applied shear stress and rate of shear, as well as the viscoelastic property including complex shear modulus and phase angle. The measured time could be converted into viscosity of asphalt binder based on calculation. This simple LPFG viscosity sensing system is hopefully expected to benefit the viscosity measurement for the field of civil, mechanical and aerospace engineering.

Poly (acrylic acid sodium) grafted carboxymethyl cellulose as a high performance polymer binder for silicon anode in lithium ion batteries

PubMed Central

Wei, Liangming; Chen, Changxin; Hou, Zhongyu; Wei, Hao

2016-01-01

The design of novel binder systems is required for the high capacity silicon (Si) anodes which usually undergo huge volume change during the charge/discharge cycling. Here, we introduce a poly (acrylic acid sodium)-grafted-carboxymethyl cellulose (NaPAA-g-CMC) copolymer as an excellent binder for Si anode in lithium ion batteries (LIBs). The NaPAA-g-CMC copolymer was prepared via a free radical graft polymerization method by using CMC and acrylic acid as precursors. Unlike the linear, one-dimensional binders, the NaPAA-g-CMC copolymer binder is expected to present multi-point interaction with Si surface, resulting in enhanced binding ability with Si particles as well as with the copper (Cu) current collectors, and building a stable solid electrolyte interface (SEI) layer on the Si surface. The NaPAA-g-CMC based Si anode shows much better cycle stability and higher coulombic efficiency than those made with the well-known linear polymeric binders such as CMC and NaPPA. PMID:26786315

Analysis of aggregates and binders used for the ODOT chip seal program.

DOT National Transportation Integrated Search

2010-11-30

This project compared the results of laboratory characterization of chip seal aggregate samples for Oklahoma DOT Divisions 1,2,3,5 and 6 with performance data from the Pavement Management System (PMS) database. Binder evaluation was limited to identi...

A Novel Polar Copolymer Design as a Multi-Functional Binder for Strong Affinity of Polysulfides in Lithium-Sulfur Batteries

NASA Astrophysics Data System (ADS)

Jiao, Yu; Chen, Wei; Lei, Tianyu; Dai, Liping; Chen, Bo; Wu, Chunyang; Xiong, Jie

2017-03-01

High energy density, low cost and environmental friendliness are the advantages of lithium-sulfur (Li-S) battery which is regarded as a promising device for electrochemical energy storage systems. As one of the important ingredients in Li-S battery, the binder greatly affects the battery performance. However, the conventional binder has some drawbacks such as poor capability of absorbing hydrophilic lithium polysulfides, resulting in severe capacity decay. In this work, we reported a multi-functional polar binder (AHP) by polymerization of hexamethylene diisocyanate (HDI) with ethylenediamine (EDA) bearing a large amount of amino groups, which were successfully used in electrode preparation with commercial sulfur powder cathodes. The abundant amide groups of the binder endow the cathode with multidimensional chemical bonding interaction with sulfur species within the cathode to inhibit the shuttling effect of polysulfides, while the suitable ductility to buffer volume change. Utilizing these advantageous features, composite C/S cathodes based the binder displayed excellent capacity retention at 0.5 C, 1 C, 1.5 C, and 3 C over 200 cycles. Accompany with commercial binder, AHP may act as an alternative feedstock to open a promising approach for sulfur cathodes in rechargeable lithium battery to achieve commercial application.

Binder model system to be used for determination of prepolymer functionality

NASA Technical Reports Server (NTRS)

Martinelli, F. J.; Hodgkin, J. H.

1971-01-01

Development of a method for determining the functionality distribution of prepolymers used for rocket binders is discussed. Research has been concerned with accurately determining the gel point of a model polyester system containing a single trifunctional crosslinker, and the application of these methods to more complicated model systems containing a second trifunctional crosslinker, monofunctional ingredients, or a higher functionality crosslinker. Correlations of observed with theoretical gel points for these systems would allow the methods to be applied directly to prepolymers.

Molecular dynamics simulations for the examination of mechanical properties of hydroxyapatite/ poly α-n-butyl cyanoacrylate under additive manufacturing.

PubMed

Wang, Yanen; Wei, Qinghua; Pan, Feilong; Yang, Mingming; Wei, Shengmin

2014-01-01

Molecular dynamics (MD) simulations emerged to be a helpful tool in the field of material science. In rapid prototyping artificial bone scaffolds process, the binder spraying volume and mechanism are very important for bone scaffolds mechanical properties. In this study, we applied MD simulations to investigating the binding energy of α-n-butyl cyanoacrylate (NBCA) on Hydroxyapatite (HA) crystallographic planes (001, 100 and 110), and to calculating and analyzing the mechanical properties and radial distribution function of the HA(110)/NBCA mixed system. The simulation results suggested that HA (110) has the highest binding energy with NBCA owing to the high planar atom density, and the mechanical properties of HA(110)/NBCA mixed system is stronger than pure HA system. Therefore, the multi-grade strength bone scaffold could be fabricated through spraying various volume NBCA binders during 3D printing process. By calculating the radial distribution function of HA(110)/NBCA, the essence of the interface interaction were successfully elucidated. The forming situation parameters can be referred to calculation results. There exists a strong interaction between HA crystallographic plane (110) and NBCA, it is mainly derived from the hydrogen bonds between O atoms which connect with C atoms of NBCA and H atoms in HA crystal. Furthermore, a strong adsorption effect can be demonstrated between HA and NBCA.

A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies.

PubMed

Trotta, Roberta; De Tito, Stefano; Lauri, Ilaria; La Pietra, Valeria; Marinelli, Luciana; Cosconati, Sandro; Martino, Luigi; Conte, Maria R; Mayol, Luciano; Novellino, Ettore; Randazzo, Antonio

2011-08-01

The growing amount of literature about G-quadruplex DNA clearly demonstrates that such a structure is no longer viewed as just a biophysical strangeness but it is instead being considered as an important target for the treatment of various human disorders such as cancers or venous thrombosis. In this scenario, with the aim of finding brand new molecular scaffolds able to interact with the groove of the DNA quadruplex [d(TGGGGT)](4), we recently performed a successful structure-based virtual screening (VS) campaign. As a result, six molecules were found to be somehow groove binders. Herein, we report the results of novel NMR titration experiments of these VS-derived ligands with modified quadruplexes, namely [d(TGG(Br)GGT)](4) and [d(TGGGG(Br)T)](4). The novel NMR spectroscopy experiments combined with molecular modelling studies, allow for a more detailed picture of the interaction between each binder and the quadruplex DNA. Noteworthy, isothermal titration calorimetry (ITC) measurements on the above-mentioned compounds revealed that 2, 4, and 6 besides their relatively small dimensions bind the DNA quadruplex [d(TGGGGT)](4) with higher affinity than distamycin A, to the best of our knowledge, the most potent groove binder identified thus far. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Targeting endogenous proteins for degradation through the affinity-directed protein missile system.

PubMed

Fulcher, Luke J; Hutchinson, Luke D; Macartney, Thomas J; Turnbull, Craig; Sapkota, Gopal P

2017-05-01

Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes. Similarly, RNA interference approaches necessitate prolonged treatments, can lead to incomplete knockdowns and are often associated with off-target effects. Targeted proteolysis can overcome these limitations. In this report, we describe an affinity-directed protein missile (AdPROM) system that harbours the von Hippel-Lindau (VHL) protein, the substrate receptor of the Cullin2 (CUL2) E3 ligase complex, tethered to polypeptide binders that selectively bind and recruit endogenous target proteins to the CUL2-E3 ligase complex for ubiquitination and proteasomal degradation. By using synthetic monobodies that selectively bind the protein tyrosine phosphatase SHP2 and a camelid-derived VHH nanobody that selectively binds the human ASC protein, we demonstrate highly efficient AdPROM-mediated degradation of endogenous SHP2 and ASC in human cell lines. We show that AdPROM-mediated loss of SHP2 in cells impacts SHP2 biology. This study demonstrates for the first time that small polypeptide binders that selectively recognize endogenous target proteins can be exploited for AdPROM-mediated destruction of the target proteins. © 2017 The Authors.

Targeting endogenous proteins for degradation through the affinity-directed protein missile system

PubMed Central

Fulcher, Luke J.; Hutchinson, Luke D.; Macartney, Thomas J.; Turnbull, Craig

2017-01-01

Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes. Similarly, RNA interference approaches necessitate prolonged treatments, can lead to incomplete knockdowns and are often associated with off-target effects. Targeted proteolysis can overcome these limitations. In this report, we describe an affinity-directed protein missile (AdPROM) system that harbours the von Hippel–Lindau (VHL) protein, the substrate receptor of the Cullin2 (CUL2) E3 ligase complex, tethered to polypeptide binders that selectively bind and recruit endogenous target proteins to the CUL2-E3 ligase complex for ubiquitination and proteasomal degradation. By using synthetic monobodies that selectively bind the protein tyrosine phosphatase SHP2 and a camelid-derived VHH nanobody that selectively binds the human ASC protein, we demonstrate highly efficient AdPROM-mediated degradation of endogenous SHP2 and ASC in human cell lines. We show that AdPROM-mediated loss of SHP2 in cells impacts SHP2 biology. This study demonstrates for the first time that small polypeptide binders that selectively recognize endogenous target proteins can be exploited for AdPROM-mediated destruction of the target proteins. PMID:28490657

Gel nanostructure in alkali-activated binders based on slag and fly ash, and effects of accelerated carbonation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernal, Susan A., E-mail: s.bernal@sheffield.ac.uk; Department of Materials Science and Engineering, The University of Sheffield, Sheffield S1 3JD; Provis, John L., E-mail: j.provis@sheffield.ac.uk

2013-11-15

Binders formed through alkali-activation of slags and fly ashes, including ‘fly ash geopolymers’, provide appealing properties as binders for low-emissions concrete production. However, the changes in pH and pore solution chemistry induced during accelerated carbonation testing provide unrealistically low predictions of in-service carbonation resistance. The aluminosilicate gel remaining in an alkali-activated slag system after accelerated carbonation is highly polymerised, consistent with a decalcification mechanism, while fly ash-based binders mainly carbonate through precipitation of alkali salts (bicarbonates at elevated CO{sub 2} concentrations, or carbonates under natural exposure) from the pore solution, with little change in the binder gel identifiable by nuclearmore » magnetic resonance spectroscopy. In activated fly ash/slag blends, two distinct gels (C–A–S–H and N–A–S–H) are formed; under accelerated carbonation, the N–A–S–H gel behaves comparably to fly ash-based systems, while the C–A–S–H gel is decalcified similarly to alkali-activated slag. This provides new scope for durability optimisation, and for developing appropriate testing methodologies. -- Highlights: •C-A-S-H gel in alkali-activated slag decalcifies during accelerated carbonation. •Alkali-activated fly ash gel changes much less under CO{sub 2} exposure. •Blended slag-fly ash binder contains two coexisting gel types. •These two gels respond differently to carbonation. •Understanding of carbonation mechanisms is essential in developing test methods.« less

Effect of Binder and Mold parameters on Collapsibility and Surface Finish of Gray Cast Iron No-bake Sand Molds

NASA Astrophysics Data System (ADS)

Srinivasulu Reddy, K.; Venkata Reddy, Vajrala; Mandava, Ravi Kumar

2017-08-01

Chemically bonded no-bake molds and cores have good mechanical properties and produce dimensionally accurate castings compared to green sand molds. Poor collapsibility property of CO2 hardened sodium silicate bonded sand mold and phenolic urethane no-bake (PUN) binder system, made the reclamation of the sands more important. In the present work fine silica sand is mixed with phenolic urethane no-bake binder and the sand sets in a very short time within few minutes. In this paper it is focused on optimizing the process parameters of PUN binder based sand castings for better collapsibility and surface finish of gray cast iron using Taguchi design. The findings were successfully verified through experiments.

Comparison between traditional strategies and classification technique (SIMCA) in the identification of old proteinaceous binders.

PubMed

Checa-Moreno, R; Manzano, E; Mirón, G; Capitan-Vallvey, L F

2008-05-15

In this paper, we performed a comparison between commonly used strategies amino acid ratios (Aa ratios), two-dimensional ratio plots (2D-Plot) and statistical correlation factor (SCF) and a classification technique, soft independent modelling of class analogy (SIMCA), to identify protein binders present in old artwork samples. To do this, we used a natural standard collection of proteinaceous binders prepared in our laboratory using old recipes and eleven samples coming from Cultural Heritage, such as mural and easel paintings, manuscripts and polychrome sculptures from the 15-18th centuries. Protein binder samples were hydrolyzed and their constitutive amino acids were determined as PITC-derivatives using HPLC-DAD. Amino acid profile data were used to perform the comparison between the four different strategies mentioned above. Traditional strategies can lead to ambiguous or non-conclusive results. With SIMCA, it is possible to provide a more robust and less subjective identification knowing the confidence level of identification. As a standard, we used proteinaceous albumin (whole egg, yolk and glair); casein (goat, cow and sheep) and collagen (mammalian and fish). The process results in a more robust understanding of proteinaceous binding media in old artworks that makes it possible to distinguish them according to their origin.

Freeforming objects with low-binder slurry

DOEpatents

Cesarano, III, Joseph; Calvert, Paul D.

2000-01-01

In a rapid prototyping system, a part is formed by depositing a bead of slurry that has a sufficient high concentration of particles to be pseudoplastic and almost no organic binders. After deposition the bead is heated to drive off sufficient liquid to cause the bead to become dilatant.

p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells.

PubMed

Křížová, Lucie; Kuchař, Milan; Petroková, Hana; Osička, Radim; Hlavničková, Marie; Pelák, Ondřej; Černý, Jiří; Kalina, Tomáš; Malý, Petr

2017-03-01

Interleukin-23 (IL-23), a heterodimeric cytokine of covalently bound p19 and p40 proteins, has recently been closely associated with development of several chronic autoimmune diseases such as psoriasis, psoriatic arthritis or inflammatory bowel disease. Released by activated dendritic cells, IL-23 interacts with IL-23 receptor (IL-23R) on Th17 cells, thus promoting intracellular signaling, a pivotal step in Th17-driven pro-inflammatory axis. Here, we aimed to block the binding of IL-23 cytokine to its cell-surface receptor by novel inhibitory protein binders targeted to the p19 subunit of human IL-23. To this goal, we used a combinatorial library derived from a scaffold of albumin-binding domain (ABD) of streptococcal protein G, and ribosome display selection, to yield a collection of ABD-derived p19-targeted variants, called ILP binders. From 214 clones analyzed by ELISA, Western blot and DNA sequencing, 53 provided 35 different sequence variants that were further characterized. Using in silico docking in combination with cell-surface competition binding assay, we identified a group of inhibitory candidates that substantially diminished binding of recombinant p19 to the IL-23R on human monocytic THP-1 cells. Of these best p19-blockers, ILP030, ILP317 and ILP323 inhibited IL-23-driven expansion of IL-17-producing primary human CD4 +  T-cells. Thus, these novel binders represent unique IL-23-targeted probes useful for IL-23/IL-23R epitope mapping studies and could be used for designing novel p19/IL-23-targeted anti-inflammatory biologics.

Paralytic shellfish poisoning (PSP) toxin binders for optical biosensor technology: problems and possibilities for the future: a review

PubMed Central

Campbell, K.; Rawn, D.F.K.; Niedzwiadek, B.; Elliott, C.T.

2011-01-01

This review examines the developments in optical biosensor technology, which uses the phenomenon of surface plasmon resonance, for the detection of paralytic shellfish poisoning (PSP) toxins. Optical biosensor technology measures the competitive biomolecular interaction of a specific biological recognition element or binder with a target toxin immobilised onto a sensor chip surface against toxin in a sample. Different binders such as receptors and antibodies previously employed in functional and immunological assays have been assessed. Highlighted are the difficulties in detecting this range of low molecular weight toxins, with analogues differing at four chemical substitution sites, using a single binder. The complications that arise with the toxicity factors of each toxin relative to the parent compound, saxitoxin, for the measurement of total toxicity relative to the mouse bioassay are also considered. For antibodies, the cross-reactivity profile does not always correlate to toxic potency, but rather to the toxin structure to which it was produced. Restrictions and availability of the toxins makes alternative chemical strategies for the synthesis of protein conjugate derivatives for antibody production a difficult task. However, when two antibodies with different cross-reactivity profiles are employed, with a toxin chip surface generic to both antibodies, it was demonstrated that the cross-reactivity profile of each could be combined into a single-assay format. Difficulties with receptors for optical biosensor analysis of low molecular weight compounds are discussed, as are the potential of alternative non-antibody-based binders for future assay development in this area. PMID:21623494

Paralytic shellfish poisoning (PSP) toxin binders for optical biosensor technology: problems and possibilities for the future: a review.

PubMed

Campbell, K; Rawn, D F K; Niedzwiadek, B; Elliott, C T

2011-06-01

This review examines the developments in optical biosensor technology, which uses the phenomenon of surface plasmon resonance, for the detection of paralytic shellfish poisoning (PSP) toxins. Optical biosensor technology measures the competitive biomolecular interaction of a specific biological recognition element or binder with a target toxin immobilised onto a sensor chip surface against toxin in a sample. Different binders such as receptors and antibodies previously employed in functional and immunological assays have been assessed. Highlighted are the difficulties in detecting this range of low molecular weight toxins, with analogues differing at four chemical substitution sites, using a single binder. The complications that arise with the toxicity factors of each toxin relative to the parent compound, saxitoxin, for the measurement of total toxicity relative to the mouse bioassay are also considered. For antibodies, the cross-reactivity profile does not always correlate to toxic potency, but rather to the toxin structure to which it was produced. Restrictions and availability of the toxins makes alternative chemical strategies for the synthesis of protein conjugate derivatives for antibody production a difficult task. However, when two antibodies with different cross-reactivity profiles are employed, with a toxin chip surface generic to both antibodies, it was demonstrated that the cross-reactivity profile of each could be combined into a single-assay format. Difficulties with receptors for optical biosensor analysis of low molecular weight compounds are discussed, as are the potential of alternative non-antibody-based binders for future assay development in this area.

[New potassium binders effective: treatment of hyperkalaemia secondary to RAAS inhibitors].

PubMed

Hoorn, Ewout J

2015-01-01

This commentary discusses two recent publications by Weir et al. and Packham et al. in The New England Journal of Medicine on the efficacy of two novel potassium binders, sodium zirconium cyclosilicate and patiromer. In a similar manner to existing potassium binders, these drugs exchange dietary potassium for either sodium or calcium in the gut, thereby preventing absorption of potassium. Both drugs were tested against placebo in patients with chronic kidney disease who developed hyperkalaemia because they were also using renin-angiotensin-aldosterone system (RAAS) inhibitors. Both drugs lowered serum potassium effectively and were tolerated reasonably well. A strong point in the trials is that the new potassium binders allow patients to continue using RAAS inhibitors. By doing so, these patients with high cardiovascular risk may continue to benefit from the protective effects of RAAS inhibitors. Limitations include the relatively short treatment period, the lack of a control group using existing potassium binders, and the exclusion of patients with severe or symptomatic hyperkalaemia.

Development of an MgO-based binder for stabilizing fine sediments and storing CO2.

PubMed

Hwang, Kyung-Yup; Ahn, Jun-Young; Kim, Cheolyong; Seo, Jeong-Yun; Hwang, Inseong

2015-12-01

An MgO-based binder was developed that could stabilize fine dredged sediments for reuse and store CO2. Initially, a binder consisting of fly ash (FA) and blast furnace slag (BFS) was developed by using alkaline activators such as KOH, NaOH, and lime. The FA0.4-BFS0.6 binder (mixed at a FA-to-BFS weight ratio of 4:6) showed the highest compressive strength of 10.7 MPa among FA/BFS binders when 5 M KOH was used. When lime (L) was tested as an alkaline activator, the strength was comparable with those obtained when KOH or NaOH was used. The L0.1-(FA0.4BFS0.6)0.9 binder (10 % lime mixed with the FA/BFS binder) showed the highest strength of 11.0 MPa. Finally, by amending this L0.1-(FA0.4BFS0.6)0.9 binder with MgO, a novel MgO-based binder (MgO0.5-(L0.1-(FA0.4BFS0.6)0.9) 0.5) was developed, which demonstrated the 28th day strength of 11.9 MPa. The MgO-based binder was successfully applied to stabilize a fine sediment to yield a compressive strength of 4.78 MPa in 365 days, which was higher than that obtained by the Portland cement (PC) system (3.22 MPa). Carbon dioxide sequestration was evidenced by three observations: (1) the decrease in pH of the treated sediment from 12.2 to 11.0; (2) the progress of the carbonation front inward the treated sediment; and (3) the presence of magnesium carbonates. The thermogravimetric analysis (TGA) results showed that 67.2 kg of CO2 per ton of the treated sediment could be stored under the atmospheric condition during 1 year.

Method for freeforming objects with low-binder slurry

DOEpatents

Cesarano, III, Joseph; Calvert, Paul D.

2002-01-01

In a rapid prototyping system, a part is formed by depositing a bead of slurry that has a sufficient high concentration of particles to be pseudoplastic and almost no organic binders. After deposition the bead is heated to drive off sufficient liquid to cause the bead to become dilatant.

The performance of blended conventional and novel binders in the in-situ stabilisation/solidification of a contaminated site soil.

PubMed

Wang, Fei; Wang, Hailing; Jin, Fei; Al-Tabbaa, Abir

2015-03-21

This paper presents an investigation of the effects of novel binders and pH values on the effectiveness of the in-situ stabilisation/solidification technique in treating heavy metals and organic contaminated soils after 1.5-year treatment. To evaluate the performance of different binders, made ground soils of SMiRT site, upto 5 m depth, were stabilised/solidified with the triple auger system and cores were taken for laboratory testing after treatment. Twenty four different binders were used including Portland cement (PC), ground granulated blastfurnace slag (GGBS), pulverised fuel ash (PFA), MgO and zeolite. Unconfined compressive strength (UCS), leachate pH and the leachability of heavy metals and total organics were applied to study the behaviours of binders in treating site soils. Under various contaminant level and binder level, the results show that UCS values were 22-3476 kPa, the leachability of the total organics was in the range of 22-241 mg/l and the heavy metals was in the range of 0.002-0.225 mg/l. In addition, the combination of GGBS and MgO at a ratio of 9:1 shows better immobilisation efficiency in treating heavy metals and organic contaminated soils after 1.5-year treatment, and the binding mechanisms under different binders were also discussed in this paper. Copyright © 2014 Elsevier B.V. All rights reserved.

Progress in the development of immunoanalytical methods incorporating recombinant antibodies to small molecular weight biotoxins.

PubMed

Kavanagh, Owen; Elliott, Christopher T; Campbell, Katrina

2015-04-01

Rapid immunoanalytical screening of food and environmental samples for small molecular weight (hapten) biotoxin contaminations requires the production of antibody reagents that possess the requisite sensitivity and specificity. To date animal-derived polyclonal (pAb) and monoclonal (mAb) antibodies have provided the binding element of the majority of these assays but recombinant antibodies (rAb) isolated from in vitro combinatorial phage display libraries are an exciting alternative due to (1) circumventing the need for experimental animals, (2) speed of production in commonly used in vitro expression systems and (3) subsequent molecular enhancement of binder performance. Short chain variable fragments (scFv) have been the most commonly employed rAb reagents for hapten biotoxin detection over the last two decades but antibody binding fragments (Fab) and single domain antibodies (sdAb) are increasing in popularity due to increased expression efficiency of functional binders and superior resistance to solvents. rAb-based immunochromatographic assays and surface plasmon resonance (SPR) biosensors have been reported to detect sub-regulatory levels of fungal (mycotoxins), marine (phycotoxins) and aquatic biotoxins in a wide range of food and environmental matrices, however this technology has yet to surpass the performances of the equivalent mAb- and pAb-based formats. As such the full potential of rAb technology in hapten biotoxin detection has yet to be achieved, but in time the inherent advantages of engineered rAb are set to provide the next generation of ultra-high performing binder reagents for the rapid and specific detection of hapten biotoxins.

Prediction of chemical speciation in stabilized/solidified wastes using a general chemical equilibrium model. Part 1: Chemical representation of cementitious binders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, J.Y.; Batchelor, B.

1999-03-01

Chemical equilibrium models are useful to evaluate stabilized/solidified waste. A general equilibrium model, SOLTEQ, a modified version of MINTEQA2 for S/S, was applied to predict the chemical speciations in the stabilized/solidified waste form. A method was developed to prepare SOLTEQ input data that can chemically represent various stabilized/solidified binders. Taylor`s empirical model was used to describe partitioning of alkali ions. As a result, SOLTEQ could represent chemical speciation in pure binder systems such as ordinary Portland cement and ordinary Portland cement + fly ash. Moreover, SOLTEQ could reasonably describe the effects on the chemical speciation due to variations in water-to-cement,more » fly ash contents, and hydration times of various binder systems. However, this application of SOLTEQ was not accurate in predicting concentrations of Ca, Si, and SO{sub 4} ions, due to uncertainties in the CSH solubility model and K{sub sp} values of cement hydrates at high pH values.« less

Design and Properties of Asphalt Concrete Mixtures Using Renewable Bioasphalt Binder

NASA Astrophysics Data System (ADS)

Setyawan, A.; Djumari; Irfansyah, P. A.; Shidiq, A. M.; Wibisono, I. S.; Fauzy, M. N.; Hadi, F. N.

2017-02-01

The needs of petroleum asphalt as materials for pavement is very large, while the petroleum classified as natural resources that cannot be renewable. As a result of petroleum dwindling and prices tend to be more expensive. So that requiring other alternative materials as a substitute for conventional asphalt derived from biomass or often called bioasphalt. This study aims to know the volumetric and Marshall characteristics on Asphalt Cement ( AC ) using the Damar asphalt modification to substitute 60/70 penetration asphalt as a binder. The volumetric and Marshall characteristic are porosity, density, flow, stability, and Marshall quotient. The characteristic of asphalt concrete at optimum bitumen content are compared to the conditions from highway agency 1987 and the general specification of asphalt concrete Bina Marga 2010 the third revision. The research uses experimental method in the laboratory with the samples made using the dasphalt modification as binder and incorporating the aggregate gradation no. VII SNI 03-1737-1989. The research is using 15 samples divided into 5 contents of damar asphalt, they are 5%, 5,5%, 6%, 6,5%, dan 7%. Tests carried out using Marshall test equipment to get the value of flow and stability and then be searched the value of optimum damar asphalt content. The result of asphalt concrete analysis using dasphalt modification as binder gives the value of optimum dasphalt content at 5,242%. The most characteristics already met the requirements and specifications.

Glyoxalated polyacrylamide as a covalently attachable and rapidly cross-linkable binder for Si electrode in lithium ion batteries

NASA Astrophysics Data System (ADS)

Yoo, Jung-Keun; Jeon, Jaebeom; Kang, Kisuk; Jung, Yeon Sik

2017-03-01

Recently, investigation of Si-based anode materials for rechargeable battery applications garnered much interest due to its exceptionally high capacity. High-capacity Si anode ( 4,200 mAhg-1) is highly desirable for the replacement of conventional graphite anode (< 400 mAhg-1) for large-scale energy-storage applications such as in electric vehicles (EVs) and energy storage systems (ESSs) for renewable energy sources. However, Si-based anodes suffer from poor cycling stability due to their large volumetric changes during repeated Li insertion. Therefore, development of highly efficient binder materials that can suppress the volume change of Si is one of the most essential parts of improving the performance of batteries. We herein demonstrate highly cross-linked polymeric binder (glyoxalated polyacrylamide) with an enhanced mechanical property by applying wet-strengthening chemistry used in paper industry. We found that the degree of cross-linking can be systematically adjusted by controlling the acidity of the slurry and has a profound effect on the cell performance using Si anode. The enhanced cycle performance of Si nanoparticles obtained by treating the binder at pH 4 can be explained by its strong interaction between the binder and Si surface and current collector, and also rigidity of binder by cross-linking.

Electron/Ion Transport Enhancer in High Capacity Li-Ion Battery Anodes

DOE PAGES

Kwon, Yo Han; Minnici, Krysten; Huie, Matthew M.; ...

2016-08-30

In this paper, magnetite (Fe 3O 4) was used as a model high capacity metal oxide active material to demonstrate advantages derived from consideration of both electron and ion transport in the design of composite battery electrodes. The conjugated polymer, poly[3-(potassium-4-butanoate) thiophene] (PPBT), was introduced as a binder component, while polyethylene glycol (PEG) was coated onto the surface of Fe 3O 4 nanoparticles. The introduction of PEG reduced aggregate size, enabled effective dispersion of the active materials and facilitated ionic conduction. As a binder for the composite electrode, PPBT underwent electrochemical doping which enabled the formation of effective electrical bridgesmore » between the carbon and Fe 3O 4 components, allowing for more efficient electron transport. Additionally, the PPBT carboxylic moieties effect a porous structure, and stable electrode performance. Finally, the methodical consideration of both enhanced electron and ion transport by introducing a carboxylated PPBT binder and PEG surface treatment leads to effectively reduced electrode resistance, which improved cycle life performance and rate capabilities.« less

Bias extension test on a bi-axial non-crimp fabric powdered with a non-reactive binder system

NASA Astrophysics Data System (ADS)

Pourtier, Jean; Duchamp, Boris; Kowalski, Maxime; Legrand, Xavier; Wang, Peng; Soulat, Damien

2018-05-01

In this communication, we investigated the effects of a chemical non-reactive binder system (powder) on the formability of NCF. Those influences are evaluated for two different of bi-axial NCF structures tested in a range of temperature [20°C - 140°] during bias extension tests (Fig. 1). This analyze is based on the study of force in function of deformation modes (slipping effects and shear angle field).

Enhanced multifunctional paint for detection of radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, Joseph C.; Moses, Edward Ira; Rubenchik, Alexander M.

An enhanced multifunctional paint apparatus, systems, and methods for detecting radiation on a surface include providing scintillation particles; providing an enhance neutron absorptive material; providing a binder; combining the scintillation particles, the enhance neutron absorptive material, and the binder creating a multifunctional paint; applying the multifunctional paint to the surface; and monitoring the surface for detecting radiation.

Si composite electrode with Li metal doping for advanced lithium-ion battery

DOEpatents

Liu, Gao; Xun, Shidi; Battaglia, Vincent

2015-12-15

A silicon electrode is described, formed by combining silicon powder, a conductive binder, and SLMP.TM. powder from FMC Corporation to make a hybrid electrode system, useful in lithium-ion batteries. In one embodiment the binder is a conductive polymer such as described in PCT Published Application WO 2010/135248 A1.

Computational screening of oxetane monomers for novel hydroxy terminated polyethers.

PubMed

Sarangapani, Radhakrishnan; Ghule, Vikas D; Sikder, Arun K

2014-06-01

Energetic hydroxy terminated polyether prepolymers find paramount importance in search of energetic binders for propellant applications. In the present study, density functional theory (DFT) has been employed to screen the various novel energetic oxetane derivatives, which usually construct the backbone for these energetic polymers. Molecular structures were investigated at the B3LYP/6-31G* level, and isodesmic reactions were designed for calculating the gas phase heats of formation. The condensed phase heats of formation for designed compounds were calculated by the Politzer approach using heats of sublimation. Among the designed oxetane derivatives, T4 and T5 possess condensed phase heat of formation above 210 kJ mol(-1). The crystal packing density of the designed oxetane derivatives varied from 1.2 to 1.6 g/cm(3). The detonation velocities and pressures were evaluated using the Kamlet-Jacobs equations, utilizing the predicted densities and HOFCond. It was found that most of the designed oxetane derivatives have detonation performance comparable to the monomers of benchmark energetic polymers viz., NIMMO, AMMO, and BAMO. The strain energy (SE) for the oxetane derivatives were calculated using homodesmotic reactions, while intramolecular group interactions were predicted through the disproportionation energies. The concept of chemical hardness is used to analyze the susceptibility of designed compounds to reactivity and chemical transformations. The heats of formation, density, and predicted performance imply that the designed molecules are expected to be candidates for polymer synthesis and potential molecules for energetic binders.

Additive Manufacturing Consolidation of Low-Cost Water Atomized Steel Powder Using Micro-Induction Sintering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, William G.; Rios, Orlando; U

ORNL worked with Grid Logic Inc to demonstrate micro induction sintering (MIS) and binder decomposition of steel powders. It was shown that MIS effectively emits spatially confined electromagnetic energy that is directly coupled to metallic powders resulting in resistive heating of individual particles. The non-uniformity of particle morphology and distribution of the water atomized steel powders resulted in inefficient transfer of energy. It was shown that adhering the particles together using polymer binders resulted in more efficient coupling. Using the MIS processes, debinding and sintering could be done in a single step. When combined with another system, such as binder-jet,more » this could reduce the amount of required post-processing. An invention disclosure was filed on hybrid systems that use MIS to reduce the amount of required post-processing.« less

Possibilities of using aluminate cements in high-rise construction

NASA Astrophysics Data System (ADS)

Kaddo, Maria

2018-03-01

The article describes preferable ways of usage of alternative binders for high-rise construction based on aluminate cements. Possible areas of rational use of aluminate cements with the purpose of increasing the service life of materials and the adequacy of the durability of materials with the required durability of the building are analyzed. The results of the structure, shrinkage and physical and mechanical properties of concrete obtained from dry mixes on the base of aluminate cements for self-leveling floors are presented. To study the shrinkage mechanism of curing binders and to evaluate the role of evaporation of water in the development of shrinkage was undertaken experiment with simple unfilled systems: gypsum binder, portland cement and «corrosion resistant high alumina cement + gypsum». Principle possibility of binder with compensated shrinkage based on aluminate cement, gypsum and modern superplasticizers was defined, as well as cracking resistance and corrosion resistance provide durability of the composition.

Density impact on performance of composite Si/graphite electrodes

DOE PAGES

Dufek, Eric J.; Picker, Michael; Petkovic, Lucia M.

2016-01-27

The ability of alkali-substituted binders for composite Si and graphite negative electrodes to minimize capacity fade for lithium ion batteries is investigated. Polymer films and electrodes are described and characterized by FTIR following immersion in electrolyte (1:2 EC:DMC) for 24 h. FTIR analysis following electrode formation displayed similar alkali-ion dependent shifts in peak location suggesting that changes in the vibrational structure of the binder are maintained after electrode formation. The Si and graphite composite electrodes prepared using the alkali-substituted polyacrylates were also exposed to electrochemical cycling and it has been found that the performance of the Na-substituted binder is superiormore » to a comparable density K-substituted system. However, in comparing performance across many different electrode densities attention needs to be placed on making comparisons at similar densities, as low density electrodes tend to exhibit lower capacity fade over cycling. This is highlighted by a 6% difference between a low density K-substituted electrode and a high density Na-substituted sample. As a result, this low variance between the two systems makes it difficult to quickly make a direct evaluation of binder performance unless electrode density is tightly controlled.« less

Powder bed binder jet 3D printing of Inconel 718: Densification, microstructural evolution and challenges

DOE PAGES

Nandwana, Peeyush; Elliott, Amy M.; Siddel, Derek; ...

2017-01-03

Traditional manufacturing of Inconel 718 components from castings and thermomechanical processing routes involve extensive post processing and machining to attain the desired geometry. Additive manufacturing (AM) technologies including direct energy deposition (DED), selective laser melting (SLM), electron beam melting (EBM) and binder jet 3D printing (BJ3DP) can minimize scrap generation and reduce lead times. While there is extensive literature on the use of melting and solidification based AM technologies, there has been limited research on the use of binder jet 3D printing. In this paper, a brief review on binder jet additive manufacturing of Inconel 718 is presented. In addition,more » existing knowledge on sintering of Inconel 718 has been extended to binder jet 3D printing. We found that supersolidus liquid phase sintering (SLPS) is necessary to achieve full densification of Inconel 718. SLPS is sensitive to the feedstock chemistry that has a strong influence on the liquid volume fraction at the processing temperature. Based on these results, we discuss an empirical framework to determine the role of powder particle size and liquid volume fraction on sintering kinetics. In conclusion, the role of powder packing factor and binder saturation on microstructural evolution is discussed. The current challenges in the use of BJ3DP for fabrication of Inconel 718, as well as, extension to other metal systems, are presented.« less

The Effect of Water or Wax-based Binders on the Chemical and Morphological Characteristics of the Margin Ceramic-Framework Interface.

PubMed

Güler, Umut; de Queiroz, José Renato Cavalcanti; de Oliveira, Luiz Fernando Cappa; Canay, Senay; Ozcan, Mutlu

2015-09-01

This study evaluated the effect of binder choice in mixing ceramic powder on the chemical and morphological features between the margin ceramic-framework interfaces. Titanium and zirconia frameworks (15 x 5 x 0.5 mm3) were veneered with margin ceramics prepared with two different binders, namely a) water/conventional or b) wax-based. For each zirconia framework material, four different margin ceramics were used: a- Creation Zi (Creation Willi Geller International); b- GC Initial Zr (GC America); Triceram (Dentaurum); and d- IPS emax (voclar Vivadent). For the titanium framework, three different margin ceramics were used: a- Creation Ti (Creation Willi Geller International); b- Triceram (Dentaurum); and c- VITA Titaniumkeramik (Vita Zahnfabrik). The chemical composition of the framework-margin ceramic interface was analyzed using Energy Dispersive X-ray Spectroscopy (EDS) and porosity level was quantified within the margin ceramic using an image program (ImageJ) from four random areas (100 x 100 pixels) on each SEM image. EDS analysis showed the presence of Carbon at the margin ceramic-framework interface in the groups where wax-based binder technique was used with the concentration being the highest for the IPS emax ZirCAD group. While IPS system (IPS ZirCAD and IPS Emax) presented higher porosity concentration using wax binder, in the other groups wax-based binder reduced the porosity of margin ceramic, except for Titanium - Triceram combination.

Shark Attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation.

PubMed

Zielonka, Stefan; Weber, Niklas; Becker, Stefan; Doerner, Achim; Christmann, Andreas; Christmann, Christine; Uth, Christina; Fritz, Janine; Schäfer, Elena; Steinmann, Björn; Empting, Martin; Ockelmann, Pia; Lierz, Michael; Kolmar, Harald

2014-12-10

A novel method for stepwise in vitro affinity maturation of antigen-specific shark vNAR domains is described that exclusively relies on semi-synthetic repertoires derived from non-immunized sharks. Target-specific molecules were selected from a CDR3-randomized bamboo shark (Chiloscyllium plagiosum) vNAR library using yeast surface display as platform technology. Various antigen-binding vNAR domains were easily isolated by screening against several therapeutically relevant antigens, including the epithelial cell adhesion molecule (EpCAM), the Ephrin type-A receptor 2 (EphA2), and the human serine protease HTRA1. Affinity maturation was demonstrated for EpCAM and HTRA1 by diversifying CDR1 of target-enriched populations which allowed for the rapid selection of nanomolar binders. EpCAM-specific vNAR molecules were produced as soluble proteins and more extensively characterized via thermal shift assays and biolayer interferometry. Essentially, we demonstrate that high-affinity binders can be generated in vitro without largely compromising the desirable high thermostability of the vNAR scaffold. Copyright © 2014 Elsevier B.V. All rights reserved.

Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders.

PubMed

Jiménez-Moreno, Ester; Montalvillo-Jiménez, Laura; Santana, Andrés G; Gómez, Ana M; Jiménez-Osés, Gonzalo; Corzana, Francisco; Bastida, Agatha; Jiménez-Barbero, Jesús; Cañada, Francisco Javier; Gómez-Pinto, Irene; González, Carlos; Asensio, Juan Luis

2016-05-25

Development of strong and selective binders from promiscuous lead compounds represents one of the most expensive and time-consuming tasks in drug discovery. We herein present a novel fragment-based combinatorial strategy for the optimization of multivalent polyamine scaffolds as DNA/RNA ligands. Our protocol provides a quick access to a large variety of regioisomer libraries that can be tested for selective recognition by combining microdialysis assays with simple isotope labeling and NMR experiments. To illustrate our approach, 20 small libraries comprising 100 novel kanamycin-B derivatives have been prepared and evaluated for selective binding to the ribosomal decoding A-Site sequence. Contrary to the common view of NMR as a low-throughput technique, we demonstrate that our NMR methodology represents a valuable alternative for the detection and quantification of complex mixtures, even integrated by highly similar or structurally related derivatives, a common situation in the context of a lead optimization process. Furthermore, this study provides valuable clues about the structural requirements for selective A-site recognition.

Sodium alginate adhesives as binders in wood fibers/textile waste fibers biocomposites for building insulation.

PubMed

Lacoste, Clément; El Hage, Roland; Bergeret, Anne; Corn, Stéphane; Lacroix, Patrick

2018-03-15

Alginate derived from seaweed is a natural polysaccharide able to form stable gel through carbohydrate functional groups largely used in the food and pharmaceutical industry. This article deals with the use of sodium alginate as an adhesive binder for wood fibres/textile waste fibres biocomposites. Several aldehyde-based crosslinking agents (glyoxal, glutaraldehyde) were compared for various wood/textile waste ratios (100/0, 50/50, 60/40, 70/30 and 0/100 in weight). The fully biomass derived composites whose properties are herewith described satisfy most of the appropriate requirements for building materials. They are insulating with a thermal conductivity in the range 0.078-0.089 W/m/K for an average density in the range 308-333 kg/m3 according to the biocomposite considered. They are semi-rigid with a maximal mechanical strength of 0.84 MPa under bending and 0.44 MPa under compression for 60/40 w/w wood/textile waste biocomposites with a glutaraldehyde crosslinking agent. Copyright © 2017 Elsevier Ltd. All rights reserved.

Optimizing the durability of the coarse fraction of porous asphalt RAP for effective recycling

NASA Astrophysics Data System (ADS)

Holleran, Irina; Wilson, Douglas J.; Black, Philippa; Holleran, Glynn; Walubita, Lubinda F.

2017-09-01

Porous asphalt (PA) durability depends not only on the binder used to manufacture the mix, but also on the aggregates chosen, particularly the coarse fraction component. Aggregates for PA should be of the highest quality and highly durable to withstand the effects of weather and traffic. To recycle PA into a new PA mix, without compromising the long-term performance, the durability of the recovered aggregates from PA-derived reclaimed asphalt pavement (RAP) should be assessed alongside the aged binder properties. In this study, the Micro-Deval (MD) Abrasion test, combined with water absorption, was found to be a good predictor of asphalt mix performance for PA. Minerology of the aggregates is an important factor when setting limits for MD loss. New Zealand (NZ) aggregates are significantly younger in geological terms, and chemically and physically less stable compared to the aggregates used in many other countries. This is especially true for greywacke, the most used aggregate in NZ for road construction. If the MD limits reported in some literature are applied to NZ PA-derived RAP aggregates, poor performing material can be erroneously incorporated in asphalt mixes. Findings from this study contributes in understanding how PA-derived RAP can be recycled into new value PA mixes.

Development of fire-resistant wood structural panels

NASA Technical Reports Server (NTRS)

Vaughan, T. W.; Etzold, R.

1977-01-01

Structural panels made with Xylok 210 resin as the binder had a burn-through resistance at least equal to the structural panels made with Kerimid 500. Therefore, because of its comparative ease of handling, Xylok 210 was selected as the resin binder to provide the baseline panel for the study of a means of improving the flame-spread resistance of the structural panels. The final resin-filler system consisted of Xylok 210 binder with the addition of ammonium oxalate and ammonium phosphate to the strands of the surface layers, using 24% of each salt based upon the air-dry weight of the strands. This system resulted in a panel with a flame-spread code of about 60, a Class 2 classification. A standard phenolic based structural panel had a flame-spread greater than 200 for laboratory prepared panels. The burn-through tests indicated an average burn-through time of 588 seconds for the specimens made with the final system. This compares to an average burn-through time of 287 seconds for the standard phenolic base structural specimen. One full-size panel was made with the final system.

High solid loading aqueous base metal/ceramic feedstock for injection molding

NASA Astrophysics Data System (ADS)

Behi, Mohammad

2001-07-01

Increasing volume fraction of metal powder in feedstock provided lower shrinkage. Reduction of the shrinkage results in better dimensional precision. The rheology of the feedstock material plays an important role to allowing larger volume fractions of the metal powder to be incorporated in the feedstock formulations. The viscosity of the feedstock mainly depends on the binder viscosity, powder volume fraction and characteristics of metal powder. Aqueous polysaccharide agar was used as a baseline binder system for this study. The effect of several gel-strengthening additives on 1.5wt% and 2wt% agar gel was evaluated. A new gel-strengthening additive was found to be the most effective among the others. The effect of other additives such as glucose, sucrose and fructose on viscosity of baseline binder and feedstock was investigated. Two new agar based binder compositions were developed. The use of these new binder formulations significantly improved the volume fraction of the metal powder, the stability of the feedstock, and reduced the final shrinkage of the molded articles. Two types of 17-4PH stainless steel metal powders, one gas atomized and, the other water atomized, were used for this research.

Phenomena during thermal removal of binders

NASA Astrophysics Data System (ADS)

Hrdina, Kenneth Edward

The research presented herein has focused on debinding of an ethylene copolymer from a SiC based molded ceramic green body. Examination of the binder burnout process was carried out by breaking down the process into two distinct regions: those events which occur before any weight loss begins, and those events occurring during binder removal. Below the temperature of observed binder loss (175sp°C), both reversible and irreversible displacement was observed to occur. The displacement was accounted for by relaxation of molding stresses, thermal expansion of the system, and melting of the semicrystalline copolymer occurring during heating. Upon further heating the binder undergoes a two stage thermal degradation process. In the first stage, acetic acid is the only degradation product formed, as determined by GC/MS analysis. In this stage, component shrinkage persisted and it was found that one unit volume of shrinkage corresponded with one unit volume of binder removed, indicating that no porosity developed. The escaping acetic acid effluents must diffuse through liquid polymer filled porous regions to escape. The gas pressure of the acetic acid species produced in the first stage of the thermal degradation may exceed the ambient pressure promoting bubble formation. Controlling the heating rate of the specimen maintains the gas pressure below the bubbling threshold and minimizes the degradation time. Experiments have determined the kinetics of the reaction in the presence of the high surface area (10-15msp2/g) ceramic powder and then verified that acetic acid was diffusing through the polymer phase to the specimen surface where evaporation is taking place. The sorption method measured the diffusivity and activity of acetic acid within the filled ceramic system within a TGA. These data were incorporated into a Fickian type model which included the rate of generation of the diffusing species. The modeling process involved prediction of the bloating temperature as a function of the sample size for a given heating rate. The predicted results and experimental results show good correlation. The model was used to optimize the heating schedule which minimized the binder removal time.

Association of pelvic fracture patterns, pelvic binder use and arterial angio-embolization with transfusion requirements and mortality rates; a 7-year retrospective cohort study.

PubMed

Agri, Fabio; Bourgeat, Mylène; Becce, Fabio; Moerenhout, Kevin; Pasquier, Mathieu; Borens, Olivier; Yersin, Bertrand; Demartines, Nicolas; Zingg, Tobias

2017-11-09

Pelvic fractures are severe injuries with frequently associated multi-system trauma and a high mortality rate. The value of the pelvic fracture pattern for predicting transfusion requirements and mortality is not entirely clear. To address hemorrhage from pelvic injuries, the early application of pelvic binders is now recommended and arterial angio-embolization is widely used for controlling arterial bleeding. Our aim was to assess the association of the pelvic fracture pattern according to the Tile classification system with transfusion requirements and mortality rates, and to evaluate the correlation between the use of pelvic binders and arterial angio-embolization and the mortality of patients with pelvic fractures. Single-center retrospective cohort study including all consecutive patients with a pelvic fracture from January 2008 to June 2015. All radiological fracture patterns were independently reviewed and grouped according to the Tile classification system. Data on patient demographics, use of pelvic binders and arterial angio-embolization, transfusion requirements and mortality were extracted from the institutional trauma registry and analyzed. The present study included 228 patients. Median patient age was 43.5 years and 68.9% were male. The two independent observers identified 105 Tile C (46.1%), 71 Tile B (31.1%) and 52 Tile A (22.8%) fractures, with substantial to almost perfect interobserver agreement (Kappa 0.70-0.83). Tile C fractures were associated with a higher mortality rate (p = 0.001) and higher transfusion requirements (p < 0.0001) than Tile A or B fractures. Arterial angio-embolization for pelvic bleeding (p = 0.05) and prehospital pelvic binder placement (p = 0.5) were not associated with differences in mortality rates. Tile C pelvic fractures are associated with higher transfusion requirements and a higher mortality rate than Tile A or B fractures. No association between the use of pelvic binders or arterial angio-embolization and survival was observed in this cohort of patients with pelvic fractures.

Method Of Characterizing An Electrode Binder

DOEpatents

Cocciantelli, Jean-Michel; Coco, Isabelle; Villenave, Jean-Jacques

1999-05-11

In a method of characterizing a polymer binder for cell electrodes in contact with an electrolyte and including a current collector and a paste containing an electrochemically active material and said binder, a spreading coefficient of the binder on the active material is calculated from the measured angle of contact between standard liquids and the active material and the binder, respectively. An interaction energy of the binder with the electrolyte is calculated from the measured angle of contact between the electrolyte and the binder. The binder is selected such that the spreading coefficient is less than zero and the interaction energy is at least 60 mJ/m.sup.2.

In Situ Imaging during Compression of Plastic Bonded Explosives for Damage Modeling

NASA Astrophysics Data System (ADS)

Yeager, John; Manner, Virginia; Patterson, Brian; Walters, David; Cordes, Nikolaus; Henderson, Kevin; Tappan, Bryce; Luscher, Darby

2017-06-01

The microstructure of plastic bonded explosives (PBXs) is known to influence behavior during insults such as deformation, heating or initiation to detonation. Obtaining three-dimensional microstructural data can be difficult due in part to fragility of the material and small feature size. X-ray computed tomography (CT) is an ideal characterization technique but the explosive crystals and binder in formulations such as PBX 9501 do not have sufficient x-ray contrast to differentiate between the components. Here, we have formulated several PBXs using octahydro-1,3,5,7-tetranitro-1,3,5,7- tetrazocine (HMX) crystals and low-density binder systems. The full three-dimensional microstructure of these samples has been characterized using microscale CT during uniaxial mechanical compression in an interrupted in situ modality. The rigidity of the binder was observed to significantly influence fracture, crystal-binder delamination, and material flow. Additionally, the segmented, 3D images were meshed for finite element simulation. Initial results of the mesoscale modeling exhibit qualitatively similar delamination. Los Alamos National Laboratory - LDRD.

Formulation design for optimal high-shear wet granulation using on-line torque measurements.

PubMed

Cavinato, Mauro; Bresciani, Massimo; Machin, Marianna; Bellazzi, Guido; Canu, Paolo; Santomaso, Andrea C

2010-03-15

An alternative procedure for achieving formulation design in a high-shear wet granulation process has been developed. Particularly, a new formulation map has been proposed which describes the onset of a significant granule growth as a function of the formulation variables (diluent, dry and liquid binder). Granule growth has been monitored using on-line impeller torque and evaluated as changes in granule particle size distribution with respect to the dry formulation. It is shown how the onset of granule growth is denoted by an abrupt increase in the torque value requires the amount of binder liquid added to be greater than a certain threshold that is identified here as 'minimum liquid volume'. This minimum liquid volume is determined as a function of dry binder type, amount, hygroscopicity and particle size distribution of diluent. It is also demonstrated how this formulation map can be constructed from independent measurements of binder glass transition temperatures using a static humidity conditioning system. 2009 Elsevier B.V. All rights reserved.

Laser-assisted manufacturing of super-insulation materials

NASA Astrophysics Data System (ADS)

Wang, Zhen; Zhang, Tao; Park, Byung Kyu; Lee, Woo Il; Hwang, David

2017-02-01

Being lightweight materials with good mechanical and thermal properties, hollow glass micro-particles (HGMPs) have been widely studied for multiple applications. In this study, it is shown that by using reduced binder fraction diluted in solvent, enables minimal contacts among the HGMPs assisted by a natural capillary trend, as confirmed by optical and electron microscope imaging. Such material architecture fabricated in a composite level proves to have enhanced thermal insulation performance through quantitative thermal conductivity measurement. Mechanical strength has also been evaluated in terms of particle-binder bonding by tensile test via in-situ microscope inspection. Effect of laser treatment was examined for further improvement of thermal and mechanical properties by selective binder removal and efficient redistribution of remaining binder components. The fabricated composite materials have potential applications to building insulation materials for their scalable manufacturing nature, improved thermal insulation performance and reasonable mechanical strength. Further studies are needed to understand mechanical and thermal properties of the resulting composites, and key fabrication mechanisms involved with laser treatment of complex multi-component and multi-phase systems.

High performance polymer chemical hydrogel-based electrode binder materials for direct borohydride fuel cells

NASA Astrophysics Data System (ADS)

Choudhury, Nurul A.; Ma, Jia; Sahai, Yogeshwar; Buchheit, Rudolph G.

Novel, cost-effective, high-performance, and environment-friendly electrode binders, comprising polyvinyl alcohol chemical hydrogel (PCH) and chitosan chemical hydrogel (CCH), are reported for direct borohydride fuel cells (DBFCs). PCH and CCH binders-based electrodes have been fabricated using a novel, simple, cost-effective, time-effective, and environmentally benign technique. Morphologies and electrochemical performance in DBFCs of the chemical hydrogel binder-based electrodes have been compared with those of Nafion ® binder-based electrodes. Relationships between the performance of binders in DBFCs with structural features of the polymers and the polymer-based chemical hydrogels are discussed. The CCH binder exhibited better performance than a Nafion ® binder whereas the PCH binder exhibited comparable performance to Nafion ® in DBFCs operating at elevated cell temperatures. The better performance of CCH binder at higher operating cell temperatures has been ascribed to the hydrophilic nature and water retention characteristics of chitosan. DBFCs employing CCH binder-based electrodes and a Nafion ®-117 membrane as an electrolyte exhibited a maximum peak power density of about 589 mW cm -2 at 70 °C.

Refined Models for an Analysis of Internal and External Buckling Modes of a Monolayer in a Layered Composite

NASA Astrophysics Data System (ADS)

Paimushin, V. N.

2017-11-01

For an analysis of internal and external buckling modes of a monolayer inside or at the periphery of a layered composite, refined geometrically nonlinear equations are constructed. They are based on modeling the monolayer as a thin plate interacting with binder layers at the points of boundary surfaces. The binder layer is modeled as a transversely soft foundation. It is assumed the foundations, previously compressed in the transverse direction (the first loading stage), have zero displacements of its external boundary surfaces at the second loading stage, but the contact interaction of the plate with foundations occurs without slippage or delamination. The deformation of the plate at a medium flexure is described by geometrically nonlinear relations of the classical plate theory based on the Kirchhoff-Love hypothesis (the first variant) or the refined Timoshenko model with account of the transverse shear and compression (the second variant). The foundation is described by linearized 3D equations of elasticity theory, which are simplified within the framework of the model of a transversely soft layer. Integrating the linearized equations along the transverse coordinate and satisfying the kinematic joining conditions of the plate with foundations, with account of their initial compression in the thickness direction, a system of 2D geometrically nonlinear equations and appropriate boundary conditions are derived. These equations describe the contact interaction between elements of the deformable system. The relations obtained are simplified for the case of a symmetric stacking sequence.

Array-Based Rational Design of Short Peptide Probe-Derived from an Anti-TNT Monoclonal Antibody.

PubMed

Okochi, Mina; Muto, Masaki; Yanai, Kentaro; Tanaka, Masayoshi; Onodera, Takeshi; Wang, Jin; Ueda, Hiroshi; Toko, Kiyoshi

2017-10-09

Complementarity-determining regions (CDRs) are sites on the variable chains of antibodies responsible for binding to specific antigens. In this study, a short peptide probe for recognition of 2,4,6-trinitrotoluene (TNT), was identified by testing sequences derived from the CDRs of an anti-TNT monoclonal antibody. The major TNT-binding site in this antibody was identified in the heavy chain CDR3 by antigen docking simulation and confirmed by an immunoassay using a spot-synthesis based peptide array comprising amino acid sequences of six CDRs in the variable region. A peptide derived from heavy chain CDR3 (RGYSSFIYWF) bound to TNT with a dissociation constant of 1.3 μM measured by surface plasmon resonance. Substitution of selected amino acids with basic residues increased TNT binding while substitution with acidic amino acids decreased affinity, an isoleucine to arginine change showed the greatest improvement of 1.8-fold. The ability to create simple peptide binders of volatile organic compounds from sequence information provided by the immune system in the creation of an immune response will be beneficial for sensor developments in the future.

Effect of X-ray Line Spectra Profile Fitting with Pearson VII, Pseudo-Voigt and Generalized Fermi Functions on Asphalt Binder Aromaticity and Crystallite Parameters

NASA Astrophysics Data System (ADS)

Gebresellasie, K.; Shirokoff, J.; Lewis, J. C.

2012-12-01

X-ray line spectra profile fitting using Pearson VII, pseudo-Voigt and generalized Fermi functions was performed on asphalt binders prior to the calculation of aromaticity and crystallite size parameters. The effects of these functions on the results are presented and discussed in terms of the peak profile fit parameters, the uncertainties in calculated values that can arise owing to peak shape, peak features in the pattern and crystallite size according to the asphalt models (Yen, modified Yen or Yen-Mullins) and theories. Interpretation of these results is important in terms of evaluating the performance of asphalt binders widely used in the application of transportation systems (roads, highways, airports).

Evaluation of hybrid binder for use in surface mixtures in Florida : final report, June 2009.

DOT National Transportation Integrated Search

2009-06-01

Binder and mixture tests were performed to evaluate the relative performance of a PG 67-22 base binder and six other commercially available binders produced by modifying the same base binder with the following modifiers: one Styrene Butadiene Styrene...

A combined approach for high-performance Li-O2 batteries: A binder-free carbon electrode and atomic layer deposition of RuO2 as an inhibitor-promoter

NASA Astrophysics Data System (ADS)

Shin, Hyun-Seop; Seo, Gi Won; Kwon, Kyoungwoo; Jung, Kyu-Nam; Lee, Sang Ick; Choi, Eunsoo; Kim, Hansung; Hwang, Jin-Ha; Lee, Jong-Won

2018-04-01

A rechargeable lithium-oxygen (Li-O2) battery is considered as a promising technology for electrochemical energy storage systems because its theoretical energy density is much higher than those of state-of-the-art Li-ion batteries. The cathode (positive electrode) for Li-O2 batteries is made of carbon and polymeric binders; however, these constituents undergo parasitic decomposition reactions during battery operation, which in turn causes considerable performance degradation. Therefore, the rational design of the cathode is necessary for building robust and high-performance Li-O2 batteries. Here, a binder-free carbon nanotube (CNT) electrode surface-modified by atomic layer deposition (ALD) of dual acting RuO2 as an inhibitor-promoter is proposed for rechargeable Li-O2 batteries. RuO2 nanoparticles formed directly on the binder-free CNT electrode by ALD play a dual role to inhibit carbon decomposition and to promote Li2O2 decomposition. The binder-free RuO2/CNT cathode with the unique architecture shows outstanding electrochemical performance as characterized by small voltage gaps (˜0.9 V) as well as excellent cyclability without any signs of capacity decay over 80 cycles.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nandwana, Peeyush; Elliott, Amy M.; Siddel, Derek

Traditional manufacturing of Inconel 718 components from castings and thermomechanical processing routes involve extensive post processing and machining to attain the desired geometry. Additive manufacturing (AM) technologies including direct energy deposition (DED), selective laser melting (SLM), electron beam melting (EBM) and binder jet 3D printing (BJ3DP) can minimize scrap generation and reduce lead times. While there is extensive literature on the use of melting and solidification based AM technologies, there has been limited research on the use of binder jet 3D printing. In this paper, a brief review on binder jet additive manufacturing of Inconel 718 is presented. In addition,more » existing knowledge on sintering of Inconel 718 has been extended to binder jet 3D printing. We found that supersolidus liquid phase sintering (SLPS) is necessary to achieve full densification of Inconel 718. SLPS is sensitive to the feedstock chemistry that has a strong influence on the liquid volume fraction at the processing temperature. Based on these results, we discuss an empirical framework to determine the role of powder particle size and liquid volume fraction on sintering kinetics. In conclusion, the role of powder packing factor and binder saturation on microstructural evolution is discussed. The current challenges in the use of BJ3DP for fabrication of Inconel 718, as well as, extension to other metal systems, are presented.« less

Final Report on Initial Samples Supplied by LLNL for Task 3.3 Binder Burnout and Sintering Schedule Optimisation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walls, P

Sixteen of the twenty-one samples have been investigated using the scanning laser dilatometer. This includes all three types of samples with different preparation routes and organic content. Cracks were observed in all samples, even those only heated to 300 C. It was concluded that the cracking was occurring in the early part of the heat treatment before the samples reached 300 C. Increase in the rate of dilation of the samples occurred above 170 C which coincided with the decomposition of the binder/wax additives as determined by differential thermal analysis. A comparison was made with SYNROC C material (Powder Runmore » 143), samples of which had been CIPed and green machined to a similar diameter and thickness as the 089mm SRTC pucks. These samples contained neither binder nor other organic processing aids and had been kept in the same desiccator as the SRTC samples. The CIPed Synroc C samples sintered to high density with zero cracks. As the cracks made up only a small contribution to the change in diameter of the sample compared to the sintering shrinkage, useful information could still be gained from the runs. The sintering curves showed that there was much greater shrinkage of the Type III samples containing only the 5% PEG binder compared to the Type I which contained polyolefin wax as processing aid. Slight changes in gradient of the sintering curve were observed, however, due to the masking effect of the cracking, full analysis of the sintering kinetics cannot be conducted. Even heating the samples to 300 C at 1.0 or 0.5 C/min could not prevent crack formation. This indicated that heating rate was not the critical parameter causing cracking of the samples. Sectioning of green bodies revealed the inhomogeneous nature of the binder/lubricant distribution in the samples. Increased homogeneity would reduce the amount of binder/lubricant required, which should in turn, reduce the degree of cracking observed during heating to the binder burnout temperature. A combination of: (1) use of a higher forming pressure, (2) reduction of organics content, (3) improvement in the distribution of the organic wax and binder components throughout the green body, could possibly alleviate cracking. Ultrasonic emulsification of the binder and wax with a small quantity of water prior to adding to the ball or attrition mill is advised to ensure more even distribution of the wax/binder system. This would also reduce the proportion of organic additives required. The binder burnout stage of the operation must first be optimized (i.e. production of pucks with no cracks) prior to optimization of the sintering stage.« less

Evaluation of Thermal Oxidative Aging Effect on the Rheological Performance of Modified Asphalt Binders

NASA Astrophysics Data System (ADS)

Zhu, Cheng

Modified asphalt binder, which is combined by base binder and additive modifier, has been implemented in pavement industry for more than 30 years. Recently, the oxidative aging mechanism of asphalt binder has been studied for several decades, and appreciable finding results of asphalt binder aging mechanism were achieved from the chemistry and rheological performance aspects. However, most of these studies were conducted with neat binders, the research of aging mechanism of modified asphalt binder was limited. Nowadays, it is still highly necessary to clarify how the asphalt binder aging happens with the modified asphalt binder, what is the effect of the different modifiers (additives) on the binder aging process, how the rheological performance changes under the thermal oxidative aging conditions and so on. The objective of this study was to investigate the effect of isothermal oxidative aging conditions on the rheological performance change of the modified and controlled asphalt binders. There were totally 14 different sorts of asphalt binders had been aged in the PAV pans in the air-force drafted ovens at 50°C, 60°C and 85°C for 0.5 day to 240 days. The Fourier-Transform Infrared Spectroscopy (FT-IR) and Dynamic Shear Rheometer (DSR) were used to perform the experiments. The analysis of rheological indices (Low shear viscosity-LSV, Crossover modulus-G*c, Glover-Rowe Parameter-G-R, DSR function-DSR Fn) as a function of carbonyl area (CA) was conducted. With the SBS modification, both of the hardening susceptibility of the rheological index-LSV and G-R decreases compared with the corresponding base binder. The TR increased the hardening susceptibility of all the rheological indexes. While for the G*c, SBS increases the slope of the most modified asphalt binders except A and B_TR_X series binders. The multiple linear regression statistical analysis results indicate that the oxidative aging conditions play an important role on the CA, and rheological performance indexes. The modifiers-SBS and TR have different directional effect on these parameters. The field asphalt binder carbonyl area prediction was conducted. The pavement temperatures which were calculated by TEMP software were input into MATLAB(TM) as a parameter with other factors, e.g the asphalt binder oxidative aging parameters, the binder film thickness, the air void radius, etc., to calculate the field asphalt CA value as a function of time out to 20 years. It was found that the different rheological index method resulted different conclusion with the asphalt binder. The SBS modified asphalt binders of A, C version and B version had close average increasing rate of LSV, higher average decreasing rate of G*c, lower average increasing rate of DSR Fn compared with the corresponding base binders. D_HPM had lower average increasing rate of LSV, G*c and DSR Fn than base binder Base D. The tire rubber modified binder B_TR had higher average increasing rate of LSV, DSR Fn, and higher average decreasing rate of G*c than base binder Base B. The main finding of this study was that the modifier SBS and tire rubber can reduce the thermal oxidation aging rate (kf and kc) compared with the corresponding base binder, the activation energy was asphalt binder source dependent. For the hardening susceptibility, the modifiers-SBS, X, Y, Z reduced the HS of LSV and G-R. The tire rubber slightly increased the HS of LSV and G-R. A_PM, B_TR_X_PM reduced the HS of G*c and other modified binders increased the HS of G*c.

Initiation disruptor systems and methods of initiation disruption

DOEpatents

Baum, Dennis W

2014-09-23

A system that may be used as an initiation disruption system (IDS) according to one embodiment includes an explosive charge; a plurality of particles in a layer at least partially surrounding the explosive charge; and a fire suppressant adjacent the plurality of particles. A method for disabling an object according to one embodiment includes placing the system as recited above near an object; and causing the explosive charge to initiate, thereby applying mechanical loading to the object such that the object becomes disabled. Additional systems and methods are also presented. A device according to another embodiment includes a plurality of particles bound by a binder thereby defining a sidewall having an interior for receiving an explosive; and a fire suppressant adjacent the plurality of particles and binder. Additional systems and methods are also presented.

Microscale Electromagnetic Heating in Heterogeneous Energetic Materials Based on X-ray Computed Tomography

NASA Astrophysics Data System (ADS)

Kort-Kamp, W. J. M.; Cordes, N. L.; Ionita, A.; Glover, B. B.; Duque, A. L. Higginbotham; Perry, W. L.; Patterson, B. M.; Dalvit, D. A. R.; Moore, D. S.

2016-04-01

Electromagnetic stimulation of energetic materials provides a noninvasive and nondestructive tool for detecting and identifying explosives. We combine structural information based on x-ray computed tomography, experimental dielectric data, and electromagnetic full-wave simulations to study microscale electromagnetic heating of realistic three-dimensional heterogeneous explosives. We analyze the formation of electromagnetic hot spots and thermal gradients in the explosive-binder mesostructures and compare the heating rate for various binder systems.

Porosity Dependence of Piezoelectric Properties for Porous Potassium Niobate System Ceramics

NASA Astrophysics Data System (ADS)

Wada, S.; Mase, Y.; Shimizu, S.; Maeda, K.; Fujii, I.; Nakashima, K.; Pulpan, P.; Miyajima, N.

2011-10-01

Porous potassium niobate (KNbO3, KN) system ceramics were prepared by a conventional sintering method using carbon black (CB) nanoparticles. First, KN nanoparticles with a size of 100 nm was mixed with CB nanoparticles and binder using ball milling with ethanol. The mixture was dried, and pressed into pellets using uniaxial pressing. After binder burnout, these ceramics was sintered in air. Their piezoelectric properties were measured and discussed a relationship between porosity and piezoelectric properties. As the results, with increasing porosity, piezoelectric g33 constant increased significantly, which suggested that porous ceramics were effective for stress sensor application.

Low vulnerability explosives (LOVEX) for mass-use warheads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pruneda, C.; Jessop, E.; McGuire, R.

1990-03-13

There is an ongoing effort at Lawrence Livermore National Laboratory to develop explosives with a significantly lower vulnerability to battlefield environments (bullets, fragments, sympathetic detonation) than current explosives (TNT and Comp B) without sacrificing performance or increasing costs. The approach taken is to develop a composite explosive which is comprised of inexpensive fillers such as RDX, NaNO{sub 3}, Al and a low modulus binder system. The binder system uses nitroglycerin/triacetin as an energetic plasticizer. This paper discusses the experimental results to date in vulnerability, performance and processing. 7 refs., 8 figs., 6 tabs.

Formulation procedure and spectral data for a coatings system optimally employing the high intrinsic reflectance of barium sulphate

NASA Technical Reports Server (NTRS)

Schutt, J. B.; Stromberg, E.; Shai, C. M.; Arens, J. F.

1972-01-01

The use of polyvinyl alcohol as a binder for barium sulphate does not allow the intrinsically high reflectance of this material in the near vacuum ultraviolet to be optimally employed. In an effort to better utilize this property, completely inorganic coatings systems are described, where from the intrinsically high reflectance of barium sulphate in this spectral region can be gotten. Potassium sulphate turns out to be the preferred binder. Compositions, formulating procedures, and application techniques are included. For completeness, absolute and relative reflectance data are included for intra- and intersystem comparisons.

14 CFR 198.15 - Non-premium insurance-payment of registration binders.

Code of Federal Regulations, 2013 CFR

2013-01-01

...—payment of registration binders. (a) The binder for initial registration is $575 for each aircraft or... registration binders. 198.15 Section 198.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... addition of an aircraft or insurable item must be accompanied by the binder for each aircraft and insurable...

14 CFR 198.15 - Non-premium insurance-payment of registration binders.

Code of Federal Regulations, 2011 CFR

2011-01-01

...—payment of registration binders. (a) The binder for initial registration is $575 for each aircraft or... registration binders. 198.15 Section 198.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... addition of an aircraft or insurable item must be accompanied by the binder for each aircraft and insurable...

14 CFR 198.15 - Non-premium insurance-payment of registration binders.

Code of Federal Regulations, 2010 CFR

2010-01-01

...—payment of registration binders. (a) The binder for initial registration is $575 for each aircraft or... registration binders. 198.15 Section 198.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... addition of an aircraft or insurable item must be accompanied by the binder for each aircraft and insurable...

14 CFR 198.15 - Non-premium insurance-payment of registration binders.

Code of Federal Regulations, 2014 CFR

2014-01-01

...—payment of registration binders. (a) The binder for initial registration is $575 for each aircraft or... registration binders. 198.15 Section 198.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... addition of an aircraft or insurable item must be accompanied by the binder for each aircraft and insurable...

Durable Hybrid Coatings. Annual Performance Report (2008)

DTIC Science & Technology

2008-09-01

points 162ensuring stabilization of the reading before moving to the next point. 163Two different thermogravimetric analysis (TGA) methods were...aluminum alloy (Al 2024). Mg-rich primers based on a hybrid organic-inorganic binder derived from silica nanoparticles and...phenethyltrimethoxysilane gave excellent corrosion protection of Al 2024-T3. Work has continued on these coatings with particular emphasis on the silica nanoparticle

Optimization of NiFe2O4/rGO composite electrode for lithium-ion batteries

NASA Astrophysics Data System (ADS)

Li, Chen; Wang, Xia; Li, Shandong; Li, Qiang; Xu, Jie; Liu, Xiaomin; Liu, Changkun; Xu, Yuanhong; Liu, Jingquan; Li, Hongliang; Guo, Peizhi; Zhao, Xiu Song

2017-09-01

The combination of carbon compositing and the proper choice of binders in one system offer an effective strategy for improving electrode performance for lithium ion batteries (LIBs). Here, we focus on the optimization of reduced graphene oxide content in NiFe2O4/reduced graphene oxide (abbreviated to NiFe2O4/rGO) composites and the proper choice of binders to enhance the cycling stability of the NiFe2O4 electrode. The NiFe2O4/rGO composites were fabricated by a hydrothermal-annealing method, in which the mean size of spinel NiFe2O4 nanoparticles was approximately 20 nm. When tested as anode materials for LIBs, the NiFe2O4/rGO electrodes with carboxymethylcellulose (CMC) binder exhibited excellent lithium-storage performance including high reversible capacity, good cycling durability and high-rate capability. The capacity could be retained as high as 1105 mAh g-1 at a current density of 100 mA g-1 for over 50 cycles, even cycled at higher current density of 1000 mA g-1, a capacity of 800 mAh g-1can be obtained, whereas the electrode with the polyvinylidene fluoride (PVDF) binder suffered from rapid capacity decay under the same test conditions. As a result, the NiFe2O4/rGO composites with CMC binder electrode in this work are promising as anodes for high-performance LIBs, resulting from the synergistic effect of optimal graphene content and proper choice of binder.

The effects of crystal proximity and crystal-binder adhesion on the thermal responses of ultrasonically-excited composite energetic materials

NASA Astrophysics Data System (ADS)

Roberts, Z. A.; Casey, A. D.; Gunduz, I. E.; Rhoads, J. F.; Son, S. F.

2017-12-01

Composite energetic materials have been shown to generate heat under certain ultrasonic excitations, enough to drive rapid reactions in some cases. In an attempt to isolate the proposed heat generation mechanisms of frictional and viscoelastic heating at crystal-crystal and crystal-binder interfaces, a systematic study was conducted with cyclotetramethylene-tetranitramine crystals arranged as discrete inclusions within Sylgard 184 binder. Groups of three embedded crystals, or "triads," were arranged in two geometries with the crystals either in contact or slightly separated. Additionally, samples with good crystal-binder adhesion as well as ones mechanically debonded using compression were considered. The samples were excited ultrasonically with a contact piezoelectric transducer, and the top surface of each sample was monitored via infrared thermography. The contacting triads showed evidence of an intense localized heat source conducting to the polymer surface above the crystal locations in contrast to the separated triads. The debonded samples of both types reached higher maximum surface temperatures, on average. The results of both two-way and nested analysis of variance indicate a statistically significant difference for both adhesion and separation distance on temperature rise. We conclude that friction between crystal contact points and a debonded, moving binder at the crystal interface (also a mode of friction) play a significant role in localized heat generation, while viscoelastic/viscoplastic heating appears comparatively minor for these specific excitation conditions. The significance of frictional heat generation over viscoelastic heating in these systems may influence future design considerations related to the selection of binder materials for composite energetic materials.

Observation of asphalt binder microstructure with ESEM.

PubMed

Mikhailenko, P; Kadhim, H; Baaj, H; Tighe, S

2017-09-01

The observation of asphalt binder with the environmental scanning electron microscope (ESEM) has shown the potential to observe asphalt binder microstructure and its evolution with binder aging. A procedure for the induction and identification of the microstructure in asphalt binder was established in this study and included sample preparation and observation parameters. A suitable heat-sampling asphalt binder sample preparation method was determined for the test and several stainless steel and Teflon sample moulds developed, finding that stainless steel was the preferable material. The magnification and ESEM settings conducive to observing the 3D microstructure were determined through a number of observations to be 1000×, although other magnifications could be considered. Both straight run binder (PG 58-28) and an air blown oxidised binder were analysed; their structures being compared for their relative size, abundance and other characteristics, showing a clear evolution in the fibril microstructure. The microstructure took longer to appear for the oxidised binder. It was confirmed that the fibril microstructure corresponded to actual characteristics in the asphalt binder. Additionally, a 'bee' micelle structure was found as a transitional structure in ESEM observation. The test methods in this study will be used for more comprehensive analysis of asphalt binder microstructure. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

The value of 'binder-off' imaging to identify occult and unexpected pelvic ring injuries.

PubMed

Fagg, James A C; Acharya, Mehool R; Chesser, Tim J S; Ward, Anthony J

2018-02-01

To determine the effectiveness of 'binder-off' plain pelvic radiographs in the assessment of pelvic ring injuries. All patients requiring operative intervention at our tertiary referral pelvic unit/major trauma centre for high-energy pelvic injuries between April 2012 and December 2014 were retrospectively identified. Pre-operative pelvic imaging with and without pelvic binder was reviewed with respect to fracture pattern and pelvic stability. The frequency with which the imaging without pelvic binder changed the opinion of the pelvic stability and need for operative intervention, when compared with the computed tomography (CT) scans and anteroposterior (AP) radiographs with the binder on, was assessed. Seventy-three percent (71 of 97) of patients had initial imaging with a pelvic binder in situ. Of these, 76% (54 of 71) went on to have 'binder-off' imaging. Seven percent (4 of 54) of patients had unexpected unstable pelvic ring injuries identified on 'binder-off' imaging that were not identified on CT imaging in binder. Trauma CT imaging of the pelvis with a pelvic binder in place is inadequate at excluding unstable pelvic ring injuries, and, based on the original findings in this paper, we recommend additional plain film 'binder-off' radiographs, when there is any clinical concern. Copyright © 2017 Elsevier Ltd. All rights reserved.

Enhanced electrochemical properties of LiFePO4 (LFP) cathode using the carboxymethyl cellulose lithium (CMC-Li) as novel binder in lithium-ion battery.

PubMed

Qiu, Lei; Shao, Ziqiang; Wang, Daxiong; Wang, Wenjun; Wang, Feijun; Wang, Jianquan

2014-10-13

Novel water-based binder CMC-Li is synthesized using cotton as raw material. The mechanism of the CMC-Li as a binder is reported. Electrochemical properties of batteries cathodes based on commercially available lithium iron phosphate (LiFePO4, LFP) and CMC-Li as a water-soluble binder are investigated. CMC-Li is a novel lithium-ion binder. Compare with conventional poly(vinylidene fluoride) (PVDF) binder, and the battery with CMC-Li as the binder retained 97.8% of initial reversible capacity after 200 cycles at 176 mAh g(-1), which is beyond the theoretical specific capacity of LFP. Constant current charge-discharge test results demonstrate that the LFP electrode using CMC-Li as the binder has the highest rate capability, follow closely by that using PVDF binder. The batteries have good electrochemical property, outstanding pollution-free and excellent stability. Copyright © 2014 Elsevier Ltd. All rights reserved.

Laser readable thermoluminescent radiation dosimeters and methods for producing thereof

DOEpatents

Braunlich, Peter F.; Tetzlaff, Wolfgang

1989-01-01

Thin layer thermoluminescent radiation dosimeters for use in laser readable dosimetry systems, and methods of fabricating such thin layer dosimeters. The thin layer thermoluminescent radiation dosimeters include a thin substrate made from glass or other inorganic materials capable of withstanding high temperatures and high heating rates. A thin layer of a thermoluminescent phoshphor material is heat bonded to the substrate using an inorganic binder such as glass. The dosimeters can be mounted in frames and cases for ease in handling. Methods of the invention include mixing a suitable phosphor composition and binder, both being in particulate or granular form. The mixture is then deposited onto a substrate such as by using mask printing techniques. The dosimeters are thereafter heated to fuse and bond the binder and phosphor to the substrate.

The effect of a new formaldehyde-free binder on the dissolution rate of glass wool fibre in physiological saline solution.

PubMed

Potter, Russell M; Olang, Nassreen

2013-04-12

The in-vitro dissolution rate of fibres is a good predictor of the in-vivo behavior and potential health effects of inhaled fibres. This study examines the effect of a new formaldehyde-free carbohydrate-polycarboxylic acid binder on the in-vitro dissolution rate of biosoluble glass fibres. Dissolution rate measurements in pH 7.4 physiological saline solution show that the presence of the binder on wool insulation glass fibres has no effect on their dissolution. There is no measurable difference between the dissolution rates of continuous draw fibres before and after binder was applied by dipping. Nor is there a measurable difference between the dissolution rates of a production glass wool sample with binder and that same sample after removal of the binder by low-temperature ashing. Morphological examination shows that swelling of the binder in the solution is at least partially responsible for the development of open channels around the glass-binder interface early in the dissolution. These channels allow fluid to reach the entire glass surface under the binder coating. There is no evidence of any delay in the dissolution rate as a result of the binder coating.

The effect of a new formaldehyde-free binder on the dissolution rate of glass wool fibre in physiological saline solution

PubMed Central

2013-01-01

The in-vitro dissolution rate of fibres is a good predictor of the in-vivo behavior and potential health effects of inhaled fibres. This study examines the effect of a new formaldehyde-free carbohydrate-polycarboxylic acid binder on the in-vitro dissolution rate of biosoluble glass fibres. Dissolution rate measurements in pH 7.4 physiological saline solution show that the presence of the binder on wool insulation glass fibres has no effect on their dissolution. There is no measurable difference between the dissolution rates of continuous draw fibres before and after binder was applied by dipping. Nor is there a measurable difference between the dissolution rates of a production glass wool sample with binder and that same sample after removal of the binder by low-temperature ashing. Morphological examination shows that swelling of the binder in the solution is at least partially responsible for the development of open channels around the glass-binder interface early in the dissolution. These channels allow fluid to reach the entire glass surface under the binder coating. There is no evidence of any delay in the dissolution rate as a result of the binder coating. PMID:23587247

Microscale electromagnetic heating in heterogeneous energetic materials based on x-ray computed tomography

DOE PAGES

Kort-Kamp, W. J. M.; Cordes, N. L.; Ionita, A.; ...

2016-04-01

Electromagnetic stimulation of energetic materials provides a noninvasive and nondestructive tool for detecting and identifying explosives. We combine structural information based on x-ray computed tomography, experimental dielectric data, and electromagnetic full-wave simulations to study microscale electromagnetic heating of realistic three-dimensional heterogeneous explosives. In conclusion, we analyze the formation of electromagnetic hot spots and thermal gradients in the explosive-binder mesostructures and compare the heating rate for various binder systems.

Microscale electromagnetic heating in heterogeneous energetic materials based on x-ray computed tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kort-Kamp, W. J. M.; Cordes, N. L.; Ionita, A.

Electromagnetic stimulation of energetic materials provides a noninvasive and nondestructive tool for detecting and identifying explosives. We combine structural information based on x-ray computed tomography, experimental dielectric data, and electromagnetic full-wave simulations to study microscale electromagnetic heating of realistic three-dimensional heterogeneous explosives. In conclusion, we analyze the formation of electromagnetic hot spots and thermal gradients in the explosive-binder mesostructures and compare the heating rate for various binder systems.

Multifunctional SA-PProDOT Binder for Lithium Ion Batteries.

PubMed

Ling, Min; Qiu, Jingxia; Li, Sheng; Yan, Cheng; Kiefel, Milton J; Liu, Gao; Zhang, Shanqing

2015-07-08

An environmentally benign, highly conductive, and mechanically strong binder system can overcome the dilemma of low conductivity and insufficient mechanical stability of the electrodes to achieve high performance lithium ion batteries (LIBs) at a low cost and in a sustainable way. In this work, the naturally occurring binder sodium alginate (SA) is functionalized with 3,4-propylenedioxythiophene-2,5-dicarboxylic acid (ProDOT) via a one-step esterification reaction in a cyclohexane/dodecyl benzenesulfonic acid (DBSA)/water microemulsion system, resulting in a multifunctional polymer binder, that is, SA-PProDOT. With the synergetic effects of the functional groups (e.g., carboxyl, hydroxyl, and ester groups), the resultant SA-PProDOT polymer not only maintains the outstanding binding capabilities of sodium alginate but also enhances the mechanical integrity and lithium ion diffusion coefficient in the LiFePO4 (LFP) electrode during the operation of the batteries. Because of the conjugated network of the PProDOT and the lithium doping under the battery environment, the SA-PProDOT becomes conductive and matches the conductivity needed for LiFePO4 LIBs. Without the need of conductive additives such as carbon black, the resultant batteries have achieved the theoretical specific capacity of LiFePO4 cathode (ca. 170 mAh/g) at C/10 and ca. 120 mAh/g at 1C for more than 400 cycles.

Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications.

PubMed

Saftic, Dijana; Ban, Zeljka; Matic, Josipa; Tumir, Lidija-Marija; Piantanida, Ivo

2018-05-07

Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class are nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder - nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Multivariate Analysis of Combined Fourier Transform Near-Infrared Spectrometry (FT-NIR) and Raman Datasets for Improved Discrimination of Drying Oils.

PubMed

Carlesi, Serena; Ricci, Marilena; Cucci, Costanza; La Nasa, Jacopo; Lofrumento, Cristiana; Picollo, Marcello; Becucci, Maurizio

2015-07-01

This work explores the application of chemometric techniques to the analysis of lipidic paint binders (i.e., drying oils) by means of Raman and near-infrared spectroscopy. These binders have been widely used by artists throughout history, both individually and in mixtures. We prepared various model samples of the pure binders (linseed, poppy seed, and walnut oils) obtained from different manufacturers. These model samples were left to dry and then characterized by Raman and reflectance near-infrared spectroscopy. Multivariate analysis was performed by applying principal component analysis (PCA) on the first derivative of the corresponding Raman spectra (1800-750 cm(-1)), near-infrared spectra (6000-3900 cm(-1)), and their combination to test whether spectral differences could enable samples to be distinguished on the basis of their composition. The vibrational bands we found most useful to discriminate between the different products we studied are the fundamental ν(C=C) stretching and methylenic stretching and bending combination bands. The results of the multivariate analysis demonstrated the potential of chemometric approaches for characterizing and identifying drying oils, and also for gaining a deeper insight into the aging process. Comparison with high-performance liquid chromatography data was conducted to check the PCA results.

Alkali-metal silicate binders and methods of manufacture

NASA Technical Reports Server (NTRS)

Schutt, J. B. (Inventor)

1979-01-01

A paint binder is described which uses a potassium or sodium silicate dispersion having a silicon dioxide to alkali-metal oxide mol ratio of from 4.8:1 to 6.0:1. The binder exhibits stability during both manufacture and storage. The process of making the binder is predictable and repeatable and the binder may be made with inexpensive components. The high mol ratio is achieved with the inclusion of a silicon dioxide hydrogel. The binder, which also employs a silicone, is in the final form of a hydrogel sol.

Phosphate binder usage in kidney failure patients.

PubMed

Bleyer, Anthony J

2003-06-01

Phosphorus binders are used in patients with kidney failure because of the incomplete removal of phosphorus with dialysis and the inability to exclude phosphorus from the diet. Aluminium was the initial phosphorus binder used, but was replaced by calcium-containing binders because of the development of aluminium toxicity. Calcium-based binders have been the mainstay of therapy for many years, but recent investigations have pointed to increased rates of vascular calcification in patients taking calcium-containing binders. For this reason, alternative agents have been developed. Sevelamer (Renagel), GelTex Pharmaceuticals Inc.) is a polymer which has been found to effectively bind phosphorus. It has resulted in a decreased rate of vascular calcification compared to calcium-containing binders. Other agents under development include lanthanum carbonate and iron-complex preparations. Further research will likely concentrate on identifying binders that bind phosphate more efficiently, have minimal gastrointestinal side effects and provide other benefits to dialysis patients.

Analyzing the influence of manufacturing conditions of reclaimed asphalt concrete on the characteristics of the asphalt binder: development of a gradual binder extraction method

NASA Astrophysics Data System (ADS)

Navaro, J.; Bruneau, D.; Drouadaine, I.; Pouteau, B.; Colin, J.; Dony, A.

2012-05-01

When asphalt concrete is manufactured incorporating a high percentage (almost 70%) of reclaimed materials from the deconstruction of road surfaces under renovation, and when the corresponding production device is designed specifically to reduce the energy input need (lowering the production temperature), the resulting manufacturing process contributes to the protection of the environment and reduces production costs. However, to meet the quality requirements of the finished product, virgin materials of appropriate quality and quantity must also be added (mineral aggregates and new asphalt binder) and control systems set up to quantify and optimize the parameters involved (thus avoiding the guess work which still often prevails today). It was for this reason that a new experimental technique described here was devised, which will ultimately be used in asphalt concrete production plants. The technique involves lixiviating reclaimed asphalt concrete using a chlorinated solvent; the resulting solute is collected gradually, then the mixture of binders (virgin and reclaimed asphalt concrete) can be characterized and their mass fractions quantified using a combination of UV and IR spectrometry. With this experimental technique we were able to assess the extent to which the reclaimed asphalt pavement binder participates in the agglomeration and cohesion of the reclaimed asphalt concrete. This assessment was made in terms of the main parameters in the production process, temperature of the materials and mixing time.

3D fabrication and characterization of phosphoric acid scaffold with a HA/β-TCP weight ratio of 60:40 for bone tissue engineering applications.

PubMed

Wang, Yanen; Wang, Kai; Li, Xinpei; Wei, Qinghua; Chai, Weihong; Wang, Shuzhi; Che, Yu; Lu, Tingli; Zhang, Bo

2017-01-01

A key requirement for three-dimensional printing (3-DP) at room temperature of medical implants depends on the availability of printable and biocompatible binder-powder systems. Different concentration polyvinyl alcohol (PVA) and phosphoric acid solutions were chosen as the binders to make the artificial stent biocompatible with sufficient compressive strength. In order to achieve an optimum balance between the bioceramic powder and binder solution, the biocompatibility and mechanical properties of these artificial stent samples were tested using two kinds of binder solutions. This study demonstrated the printable binder formulation at room temperature for the 3D artificial bone scaffolds. 0.6 wt% PVA solution was ejected easily via inkjet printing, with a supplementation of 0.25 wt% Tween 80 to reduce the surface tension of the polyvinyl alcohol solution. Compared with the polyvinyl alcohol scaffolds, the phosphoric acid scaffolds had better mechanical properties. Though both scaffolds supported the cell proliferation, the absorbance of the polyvinyl alcohol scaffolds was higher than that of the phosphoric acid scaffolds. The artificial stents with a hydroxyapatite/beta-tricalcium phosphate (HA/β-TCP) weight ratios of 60:40 depicted good biocompatibility for both scaffolds. Considering the scaffolds' mechanical and biocompatible properties, the phosphoric acid scaffolds with a HA/β-TCP weight ratio of 60:40 may be the best combination for bone tissue engineering applications.

Hydrocarbon polymeric binder for advanced solid propellant

NASA Technical Reports Server (NTRS)

Potts, J. E. (Editor); Ashcraft, A. C., Jr.; Wise, E. W.

1971-01-01

The results of curing vinyl alcohol terpolymers of ethylene, propylene and vinyl acetate are reported for an average functionality of 1.24 when reacted with an equivalent amount of diisocynate, and saturated polyisoprene derivative is described having terminal methyl ester functionality. The development is reported of two hydroxy-telechelic polyisoprenes prepared by DEAB initiated free radical polymerization followed by LiAlH4 reduction of the end groups.

ATTRITION RESISTANT IRON-BASED FISCHER-TROPSCH CATALYSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

JAMES G. GOODWIN, JR.; JAMES J. SPIVEY; K. JOTHIMURUGESAN

1998-09-17

The Fischer-Tropsch (F-T) reaction provides a way of converting coal-derived synthesis gas (CO+H{sub 2}) to liquid fuels. Since the reaction is highly exothermic, one of the major problems in control of the reaction is heat removal. Recent work has shown that the use of slurry bubble column reactors (SBCRs) can largely solve this problem. Iron-based (Fe) catalysts are preferred catalysts for F-T when using low CO/H{sub 2} ratio synthesis gases derived from modern coal gasifiers. This is because in addition to reasonable F-T activity, the F-T catalysts also possess high water gas shift (WGS) activity. However, a serious problem withmore » the use of Fe catalysts in a SBCR is their tendency to undergo attrition. This can cause fouling/plugging of downstream filters and equipment, making the separation of catalyst from the oil/wax product very difficult if not impossible, and results in a steady loss of catalyst from the reactor. The objectives of this research are to develop a better understanding of the parameters affecting attrition resistance of Fe F-T catalysts suitable for use in SBCRs and to incorporate this understanding into the design of novel Fe catalysts having superior attrition resistance. Catalyst preparations will be based on the use of spray drying and will be scalable using commercially available equipment. The research will employ among other measurements, attrition testing and F-T synthesis, including long duration slurry reactor runs in order to ascertain the degree of success of the various preparations. The goal is to develop an Fe catalyst which can be used in a SBCR having only an internal filter for separation of the catalyst from the liquid product, without sacrificing F-T activity and selectivity. The effect of silica addition via coprecipitation and as a binder to a doubly promoted Fischer-Tropsch synthesis iron catalyst (100 Fe/5 Cu/4.2 K) was studied. The catalysts were prepared by coprecipitation, followed by binder addition and drying in a 1 m diameter, 2 m tall spray dryer. The binder silica content was varied from 0 to 20 wt %. A catalyst with 12 wt % binder silica was found to have the highest attrition resistance. F-T reaction studies over 100 hours in a fixed-bed reactor showed that this catalyst maintained around 95 % CO conversion with a methane selectivity of less than 7 wt % and a C{sub 5}{sup +} selectivity of greater than 73 wt %. The effect of adding precipitated silica from 0 to 20 parts by weight to this catalyst (containing 12 wt % binder silica) was also studied. Addition of precipitated silica was found to be detrimental to attrition resistance and resulted in increased methane and reduced wax formation.« less

Economic evaluations of interventions to manage hyperphosphataemia in adult haemodialysis patients: A systematic review.

PubMed

Rizk, Rana; Hiligsmann, Mickaël; Karavetian, Mirey; Evers, Silvia Maa

2016-03-01

Managing hyperphosphataemia in haemodialysis patients is resource-intensive. A search for cost-effective interventions in this field is needed to inform decisions on the allocation of healthcare resources. NHSEED, MEDLINE, EMBASE and CINAHL were searched for full economic evaluations of hyperphosphataemia-managing interventions in adult haemodialysis patients, published between 2004 and 2014, in English, French, Dutch or German. Incremental cost-effectiveness ratios of the interventions were up-rated to 2013US$ using Purchasing Power Parity conversion rates and Consumer Price Indices. The quality of included studies was assessed using the Extended Consensus on Health Economic Criteria List. Twelve out of the 1681 retrieved records fulfilled the inclusion criteria. They reported only on one aspect of hyperphosphataemia management, which is the use of phosphate binders (calcium-based and calcium-free, in first-line and sequential use). No economic evaluations of other phosphorus-lowering interventions were found. The included articles derived from five countries and most of them were funded by pharmaceutical companies. The incremental cost-effectiveness ratios of phosphate binders ranged between US$11 461 and US$157 760 per quality-adjusted life-year gained. Calcium-based binders (especially calcium acetate) appear to be the optimal cost-effective first- and second-line therapy in prevalent patients, while the calcium-free binder, lanthanum carbonate, might provide good value for money, as second-line therapy, in incident patients. The studies' overall quality was suboptimal. Drawing firm conclusions was not possible due to the quality heterogeneity and inconsistent results. Future high-quality economic evaluations are needed to confirm the findings of this review and to address other interventions to manage hyperphosphataemia in this population. © 2015 Asian Pacific Society of Nephrology.

Preclinical studies of VS‐505: a non‐absorbable highly effective phosphate binder

PubMed Central

Chen, Yung‐wu; Wong, Jonathan T; Wessale, Jerry L

2016-01-01

Abstract Background and Purpose Phosphate imbalance is often present in chronic kidney disease (CKD), and it contributes to a higher cardiovascular mortality rate. A phosphate binder is typically part of a treatment strategy for controlling phosphate imbalance. However, safety concerns and low compliance are two well‐recognized disadvantages of on‐market phosphate binders. This report describes the preclinical studies of VS‐505, a non‐absorbable, calcium‐ and aluminum‐free, plant‐derived polymer currently being evaluated in haemodialysis patients in Australia. Experimental Approach Normal Sprague Dawley (SD) rats or uraemic SD rats induced by 5/6 nephrectomy fed a high‐phosphate diet were treated with VS‐505 or sevelamer (0.05–10% in food) for 5 and 28 days respectively. Key Results Urinary and serum phosphate levels were significantly elevated in untreated rats, and were decreased by VS‐505 and sevelamer. VS‐505 increased faecal phosphate levels in a dose‐dependent manner. High‐phosphate diet also caused an increase in serum FGF‐23 and parathyroid hormone in nephrectomized (NX) rats, effects prevented by VS‐505 or sevelamer. Significant aortic calcification was observed in NX rats treated with 5% sevelamer, whereas VS‐505 at all doses tested did not show effects. VS‐505 had no effects on small intestine histomorphology and intestinal sodium‐dependent phosphate cotransporter gene expression. In vitro characterizations showed that VS‐505 has a relatively high density and low expansion volume when exposed to simulated gastric fluid. Conclusions and Implications VS‐505 is a safe and effective phosphate binder and may offer the advantage of having a reduced pill burden and minimal GI side effects for CKD patients. PMID:27156057

Effect of recovered binders from recycled shingles and increased RAP percentages on resultant binder PG.

DOT National Transportation Integrated Search

2011-12-01

This research evaluated the properties of recycled asphalt binders from Wisconsin sources. Continuous grading : properties were measured for 18 recycled binder sources: 12 reclaimed asphalt pavement (RAP) sources and 6 recycled : asphalt shingle sour...

Proton conducting membrane using a solid acid

NASA Technical Reports Server (NTRS)

Boysen, Dane A. (Inventor); Narayanan, Sekharipuram R. (Inventor); Haile, Sossina M. (Inventor); Chisholm, Calum (Inventor)

2006-01-01

A solid acid material is used as a proton conducting membrane in an electrochemical device. The solid acid material can be one of a plurality of different kinds of materials. A binder can be added, and that binder can be either a nonconducting or a conducting binder. Nonconducting binders can be, for example, a polymer or a glass. A conducting binder enables the device to be both proton conducting and electron conducting.

Distribution of a viscous binder during high shear granulation--sensitivity to the method of delivery and its impact on product properties.

PubMed

Tan, Bernice Mei Jin; Loh, Zhi Hui; Soh, Josephine Lay Peng; Liew, Celine Valeria; Heng, Paul Wan Sia

2014-01-02

Binder distribution in the powder mass during high shear granulation is especially critical with the use of viscous liquid binders and with short processing times. A viscous liquid binder was delivered into the powder mass at two flow rates using three methods: pouring, pumping and spraying from a pressure pot. Binder content analyses at the scale of individual granules were conducted to investigate the impact of different delivery conditions on the homogeneity of binder distribution. There was clear evidence of non-uniformity of binder content among individual granules across all delivery conditions, particularly for the fast rates of delivery. Poorer reproducibility values of tablet thickness and disintegration time were observed when binder was poured but this may be overcome by pumping or spraying from the pressure pot. Greater homogeneity of binder distribution occurred with the slow rates of delivery and led to the earlier onset of granule growth and a consequent increase in granule size. Larger granule size and lower proportion of fines were in turn associated with increased granule bulk density and improvement of granule flow. In conclusion, delivery of a viscous binder at a slow rate either by pumping or via a pressure pot was most desirable during granulation. Copyright © 2013 Elsevier B.V. All rights reserved.

Adherence to phosphate binders in hemodialysis patients: prevalence and determinants.

PubMed

Van Camp, Yoleen P M; Vrijens, Bernard; Abraham, Ivo; Van Rompaey, Bart; Elseviers, Monique M

2014-12-01

Phosphate control is a crucial treatment goal in end-stage renal disease, but poor patient adherence to phosphate binder therapy remains a challenge. This study aimed to estimate the extent of phosphate binder adherence in hemodialysis patients and to identify potential determinants. Phosphate binder adherence was measured blindly in 135 hemodialysis patients for 2 months using the medication event monitoring system. Patient data, gathered at inclusion through medical records, ad hoc questionnaires and the short form (SF)-36 health survey, included: (1) demographics, (2) perceived side-effects, belief in benefit, self-reported adherence to the therapy, (3) knowledge about phosphate binder therapy, (4) social support, and (5) quality of life (SF-36). Phosphatemia data was collected from charts. 'Being adherent' was defined as missing <1 total daily dose/week and 'being totally adherent' as missing <1 total daily dose/week, every week. Mean age of patients was 67 years and 64 % of the sample was male. Over the 2 months, 78 % of the prescribed doses were taken. Every week, about half of patients were adherent. Over the entire 8-week period, 22 % of patients were totally adherent. Mean phosphatemia levels were 0.55 mg/dl lower in adherent than nonadherent patients (4.76 vs. 5.31 mg/dl). Determinants for being totally adherent were living with a partner, higher social support (both were interrelated) and higher physical quality of life. Experiencing intake-related inconvenience negatively affected adherence. The social support and quality of life physical score explained 26 % of the variance in adherence. Phosphate binder nonadherence remains a major problem. Interventions should aim, at least, to improve social support. With few associated factors found and yet low adherence, an individualized approach seems indicated.

Polyamidoamine dendrimer-based binders for high-loading lithium–sulfur battery cathodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhattacharya, Priyanka; Nandasiri, Manjula I.; Lv, Dongping

2016-01-01

Lithium-sulfur (Li-S) batteries are regarded as one of the most promising candidates for next generation energy storage systems because of their ultra high theoretical specific energy. To realize the practical application of Li-S batteries, however, a high S active material loading is essential (>70 wt% in the carbon-sulfur (C-S) composite cathode and >2 mg cm-2 in the electrode). A critical challenge to achieving this high capacity in practical electrodes is the dissolution of the longer lithium polysulfide reaction intermediates in the electrolyte (resulting in loss of active material from the cathode and contamination of the anode due to the polysulfidemore » shuttle mechanism). The binder material used for the cathode is therefore crucial as this is a key determinant of the bonding interactions between the active material (S) and electronic conducting support (C), as well as the maintenance of intimate contact between the electrode materials and current collector. The battery performance can thus be directly correlated with the choice of binder, but this has received only minimal attention in the relevant Li-S battery published literature. Here, we investigated the application of polyamidoamine (PAMAM) dendrimers as functional binders in Li-S batteries—a class of materials which has been unexplored for electrode design. By using dendrimers, it is demonstrated that high S loadings (>4 mg cm-2) can be easily achieved using "standard" (not specifically tailored) materials and simple processing methods. An exceptional electrochemical cycling performance was obtained (as compared to cathodes with conventional linear polymeric binders such as carboxymethyl cellulose (CMC) and styrene-butadiene rubber (SBR)) with >100 cycles and 85-98% capacity retention, thus demonstrating the significant utility of this new binder architecture which exhibits critical physicochemical properties and flexible nanoscale design parameters (CNDP's).« less

Process for producing an activated carbon adsorbent with integral heat transfer apparatus

NASA Technical Reports Server (NTRS)

Jones, Jack A. (Inventor); Yavrouian, Andre H. (Inventor)

1996-01-01

A process for producing an integral adsorbent-heat exchanger apparatus useful in ammonia refrigerant heat pump systems. In one embodiment, the process wets an activated carbon particles-solvent mixture with a binder-solvent mixture, presses the binder wetted activated carbon mixture on a metal tube surface and thereafter pyrolyzes the mixture to form a bonded activated carbon matrix adjoined to the tube surface. The integral apparatus can be easily and inexpensively produced by the process in large quantities.

An evaluation of dry film lubricants and substrate materials for use on SSME gimbal bearings

NASA Technical Reports Server (NTRS)

Harp, J. A.

1976-01-01

Failure of the spherical bearing shaft of the Space Shuttle Main Engine (SSME) gimbal bearing assembly was encountered during Design Verification Specification testing of the full scale engine. Investigation revealed that the failure was caused by a deficiency in the lubrication system. Based upon the materials and gimbal operating conditions, a lubricant of MoS2 and graphite with a ceramic binder was the best lubricant candidate for this particular application; however, the decision to implement the change was not made without verification testing. Scaled down simulation testing was performed. Four different substrate materials and eight different dry film lubricants were subjected to tests under simulated SSME environmental and stress load conditions. The test specimens were evaluated for friction and operating life. Each test specimen was subjected to cyclic operation under load until failure. The force required to move the bearing surfaces relative to each other was monitored throughout the test, thus providing analytical data for derivation of the coefficient of friction. Results indicate that the MoS2/graphite lubricant with ceramic binder proved to be superior from the standpoint of endurance and also from the standpoint of friction reducing capabilities when applied to the titanium substrate material used on SSME. Endurance of this lubricant was approximately 16 times that of the lubricant which was being used when the SSME gimbal failed.

Fatigue and fracture properties of aged binders in the context of reclaimed asphalt mixes.

DOT National Transportation Integrated Search

2014-08-01

Evidence in the literature indicates that the stiffness of the asphalt binder increases and ductility of the binder decreases : with oxidative aging. Typically for unmodified asphalt binders, increase in stiffness or decrease in ductility is regarded...

Laser readable thermoluminescent radiation dosimeters and methods for producing thereof

DOEpatents

Braunlich, P.F.; Tetzlaff, W.

1989-04-25

Thin layer thermoluminescent radiation dosimeters for use in laser readable dosimetry systems, and methods of fabricating such thin layer dosimeters are disclosed. The thin layer thermoluminescent radiation dosimeters include a thin substrate made from glass or other inorganic materials capable of withstanding high temperatures and high heating rates. A thin layer of a thermoluminescent phosphor material is heat bonded to the substrate using an inorganic binder such as glass. The dosimeters can be mounted in frames and cases for ease in handling. Methods of the invention include mixing a suitable phosphor composition and binder, both being in particulate or granular form. The mixture is then deposited onto a substrate such as by using mask printing techniques. The dosimeters are thereafter heated to fuse and bond the binder and phosphor to the substrate. 34 figs.

Development of non-petroleum-based binders for use in flexible pavements - phase II.

DOT National Transportation Integrated Search

2015-10-01

Bio-binders can be utilized as asphalt modifiers, extenders, and replacements for conventional asphalt in bituminous binders. : From the rheology results of Phase I of this project, it was found that the bio-binders tested had good performance, simil...

High-Density IgE Recognition of the Major Grass Pollen Allergen Phl p 1 Revealed with Single-Chain IgE Antibody Fragments Obtained by Combinatorial Cloning

PubMed Central

Madritsch, Christoph; Gadermaier, Elisabeth; Roder, Uwe W.; Lupinek, Christian; Valenta, Rudolf; Flicker, Sabine

2015-01-01

The timothy grass pollen allergen Phl p 1 belongs to the group 1 of highly cross-reactive grass pollen allergens with a molecular mass of ~25–30 kDa. Group 1 allergens are recognized by >95% of grass pollen allergic patients. We investigated the IgE recognition of Phl p 1 using allergen-specific IgE-derived single-chain variable Ab fragments (IgE-ScFvs) isolated from a combinatorial library constructed from PBMCs of a grass pollen–allergic patient. IgE-ScFvs reacted with recombinant Phl p 1 and natural group 1 grass pollen allergens. Using synthetic Phl p 1–derived peptides, the binding sites of two ScFvs were mapped to the N terminus of the allergen. In surface plasmon resonance experiments they showed comparable high-affinity binding to Phl p 1 as a complete human IgE-derived Ab recognizing the allergens’ C terminus. In a set of surface plasmon resonance experiments simultaneous allergen recognition of all three binders was demonstrated. Even in the presence of the three binders, allergic patients’ polyclonal IgE reacted with Phl p 1, indicating high-density IgE recognition of the Phl p 1 allergen. Our results show that multiple IgE Abs can bind with high density to Phl p 1, which may explain the high allergenic activity and sensitizing capacity of this allergen. PMID:25637023

Electrochemical lithiation performance and characterization of silicon-graphite composites with lithium, sodium, potassium, and ammonium polyacrylate binders.

PubMed

Han, Zhen-Ji; Yamagiwa, Kiyofumi; Yabuuchi, Naoaki; Son, Jin-Young; Cui, Yi-Tao; Oji, Hiroshi; Kogure, Akinori; Harada, Takahiro; Ishikawa, Sumihisa; Aoki, Yasuhito; Komaba, Shinichi

2015-02-07

Poly(acrylic acid) (PAH), which is a water soluble polycarboxylic acid, is neutralized by adding different amounts of LiOH, NaOH, KOH, and ammonia (NH4OH) aqueous solutions to fix neutralization degrees. The differently neutralized polyacid, alkali and ammonium polyacrylates are examined as polymeric binders for the preparation of Si-graphite composite electrodes as negative electrodes for Li-ion batteries. The electrode performance of the Si-graphite composite depends on the alkali chemicals and neutralization degree. It is found that 80% NaOH-neutralized polyacrylate binder (a pH value of the resultant aqueous solution is ca. 6.7) is the most efficient binder to enhance the electrochemical lithiation and de-lithiation performance of the Si-graphite composite electrode compared to that of conventional PVdF and the other binders used in this study. The optimum polyacrylate binder highly improves the dispersion of active material in the composite electrode. The binder also provides the strong adhesion, suitable porosity, and hardness for the composite electrode with 10% (m/m) binder content, resulting in better electrochemical reversibility. From these results, the factors of alkali-neutralized polyacrylate binders affecting the electrode performance of Si-graphite composite electrodes are discussed.

Effects of binders on the electrochemical performance of rechargeable magnesium batteries

NASA Astrophysics Data System (ADS)

Wang, Nan; NuLi, Yanna; Su, Shuojian; Yang, Jun; Wang, Jiulin

2017-02-01

A comparative study on the effects of different binders on the electrochemical performance of rechargeable magnesium batteries with Mo6S8 cathode is conducted for the first time. The selected binders are commercial organic-soluble polyvinylidene fluoride (PVDF), water-soluble poly(acrylic acid) (PAA), poly(vinyl alcohol) (PVA), gelatin, sodium alginate (SA) and Beta-cyclodextrin (β-CD). The binders significantly affect the physical properties, thus the electrochemical performance of Mo6S8 cathode. Compared with those using traditional PVDF binder, Mo6S8 electrodes with PAA and PVA exhibit enhanced cycling stabilities and rate capabilities, which are attributed to the improved cohesion among the electrode constituents and adhesion between the electrode laminate and the current collector. In addition, the anodic stability of these binders is not only related to the chemical structure of binders, but also to the uniformity of electrode surface. SA binder shows low anodic stability duo to containing easily oxidized groups. Non-uniform electrode surface decreases the anodic stability of PVDF based Mo6S8 electrode. Gelatin can be used as a binder in the formulation of high voltage cathodes for rechargeable magnesium batteries.

21 CFR 880.5160 - Therapeutic medical binder.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Therapeutic medical binder. 880.5160 Section 880...) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use Therapeutic Devices § 880.5160 Therapeutic medical binder. (a) Identification. A therapeutic medical binder is a...

21 CFR 880.5160 - Therapeutic medical binder.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Therapeutic medical binder. 880.5160 Section 880...) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use Therapeutic Devices § 880.5160 Therapeutic medical binder. (a) Identification. A therapeutic medical binder is a...

Elastic and Sorption Characteristics of an Epoxy Binder in a Composite During Its Moistening

NASA Astrophysics Data System (ADS)

Aniskevich, K.; Glaskova, T.; Jansons, J.

2005-07-01

Results of an experimental investigation into the elastic and sorption characteristics of a model composite material (CM) — epoxy resin filled with LiF crystals — during its moistening are presented. Properties of the binder in the CM with different filler contents ( v f = 0, 0.05, 0.11, 0.23, 0.28, 0.33, 0.38, and 0.46) were evaluated indirectly by using known micromechanical models of CMs. It was revealed that, for the CM in a conditionally initial state, the elastic modulus of the binder in it and the filler microstrain (change in the interplanar distance in the crystals, measured by the X-ray method) as functions of filler content had the same character. The elastic modulus of the binder in the CM with a low filler content was equal to that for the binder in a block; the elastic modulus of the binder in the CM decreased with increasing filler content. The maximum (corresponding to water saturation of the CM) stresses in the binder and the filler microstresses as functions of filler content were of the same character. Moreover, the absolute values of maximum stresses in the binder and of filler microstresses coincided for high and low contents of the filler. At v f = 0.2-0. 3, the filler microstrains exceeded the stresses in the binder. The effect of moisture on the epoxy binder in the CM with a high filler content was not entirely reversible: the elastic characteristics of the binder increased, the diffusivity decreased, and the ultimate water content increased after a moistening-drying cycle.

47 CFR 51.232 - Binder group management.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 3 2012-10-01 2012-10-01 false Binder group management. 51.232 Section 51.232... Obligations of All Local Exchange Carriers § 51.232 Binder group management. (a) With the exception of loops..., segregating or reserving particular loops or binder groups for use solely by any particular advanced services...

47 CFR 51.232 - Binder group management.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 3 2013-10-01 2013-10-01 false Binder group management. 51.232 Section 51.232... Obligations of All Local Exchange Carriers § 51.232 Binder group management. (a) With the exception of loops..., segregating or reserving particular loops or binder groups for use solely by any particular advanced services...

47 CFR 51.232 - Binder group management.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 3 2011-10-01 2011-10-01 false Binder group management. 51.232 Section 51.232... Obligations of All Local Exchange Carriers § 51.232 Binder group management. (a) With the exception of loops..., segregating or reserving particular loops or binder groups for use solely by any particular advanced services...

46 CFR 308.3 - Applications for insurance; warranties; supporting documents; payment of binder fees.

Code of Federal Regulations, 2012 CFR

2012-10-01

... documents; payment of binder fees. 308.3 Section 308.3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.3 Applications for insurance; warranties; supporting documents; payment of binder fees. (a) Application, binder forms. A single application for War...

46 CFR 308.3 - Applications for insurance; warranties; supporting documents; payment of binder fees.

Code of Federal Regulations, 2014 CFR

2014-10-01

... documents; payment of binder fees. 308.3 Section 308.3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.3 Applications for insurance; warranties; supporting documents; payment of binder fees. (a) Application, binder forms. A single application for War...

46 CFR 308.3 - Applications for insurance; warranties; supporting documents; payment of binder fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... documents; payment of binder fees. 308.3 Section 308.3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.3 Applications for insurance; warranties; supporting documents; payment of binder fees. (a) Application, binder forms. A single application for War...

46 CFR 308.3 - Applications for insurance; warranties; supporting documents; payment of binder fees.

Code of Federal Regulations, 2013 CFR

2013-10-01

... documents; payment of binder fees. 308.3 Section 308.3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.3 Applications for insurance; warranties; supporting documents; payment of binder fees. (a) Application, binder forms. A single application for War...

Microstructure of the combustion zone: Thin-binder AP-polymer sandwiches

NASA Technical Reports Server (NTRS)

Price, E. W.; Panyam, R. R.; Sigman, R. K.

1980-01-01

Experimental results are summarized for systematic quench-burning tests on ammonium perchlorate-HC binder sandwiches with binder thicknesses in the range 10 - 150 microns. Tests included three binders (polysulfide, polybutadiene-acrylonitrile, and hydroxy terminated polybutadiene), and pressures from 1.4 to 14 MPa. In addition, deflagration limits were determined in terms of binder thickness and pressure. Results are discussed in terms of a qualitative theory of sandwich burning consolidated from various sources. Some aspects of the observed results are explained only speculatively.

Color-coding and human factors engineering to improve patient safety characteristics of paper-based emergency department clinical documentation.

PubMed

Kobayashi, Leo; Boss, Robert M; Gibbs, Frantz J; Goldlust, Eric; Hennedy, Michelle M; Monti, James E; Siegel, Nathan A

2011-01-01

Investigators studied an emergency department (ED) physical chart system and identified inconsistent, small font labeling; a single-color scheme; and an absence of human factors engineering (HFE) cues. A case study and description of the methodology with which surrogate measures of chart-related patient safety were studied and subsequently used to reduce latent hazards are presented. Medical records present a challenge to patient safety in EDs. Application of HFE can improve specific aspects of existing medical chart organization systems as they pertain to patient safety in acute care environments. During 10 random audits over 5 consecutive days (573 data points), 56 (9.8%) chart binders (range 0.0-23%) were found to be either misplaced or improperly positioned relative to other chart binders; 12 (21%) were in the critical care area. HFE principles were applied to develop an experimental chart binder system with alternating color-based chart groupings, simple and prominent identifiers, and embedded visual cues. Post-intervention audits revealed significant reductions in chart binder location problems overall (p < 0.01), for Urgent Care A and B pods (6.4% to 1.2%; p < 0.05), Fast Track C pod (19.3% to 0.0%; p < 0.05) and Behavioral/Substance Abuse D pod (15.7% to 0.0%; p < 0.05) areas of the ED. The critical care room area did not display an improvement (11.4% to 13.2%; p = 0.40). Application of HFE methods may aid the development, assessment, and modification of acute care clinical environments through evidence-based design methodologies and contribute to safe patient care delivery.

Graphene oxide as a dual-function conductive binder for PEEK-derived microporous carbons in high performance supercapacitors

NASA Astrophysics Data System (ADS)

Kim, Christine H. J.; Zhang, Hongbo; Liu, Jie

2015-06-01

Microporous carbons (MPCs) are promising electrode materials for supercapacitors because of their high surface area and accessible pores. However, their low electrical conductivity and mechanical instability result in limited power density and poor cycle life. This work proposes a unique two-layered film made of polyetheretherketone-derived MPCs and reduced graphene oxide (rGO) as an electrode for supercapacitors. Electrochemical characterizations of films show that such a layered structure is more effective in increasing the accessibility of ions to the hydrophilic MPCs and establishing conductive paths through the rGO network than a simple mixed composite film. The two-layered structure increases the capacitance by ˜124% (237 F g-1) with excellent cycling stability (˜93% after 6000 cycles). More importantly, we demonstrate that such performance improvements result from an optimal balance between electrical conductivity and ion accessibility, which maximizes the synergistic effects of MPC and rGO. The MPCs, which are exposed to the surface, provide a highly accessible surface area for ion adsorption. The rGO serves a dual function as a conductive filler to increase the electrical conductivity and as a binder to interconnect individual MPC particles into a robust and flexible film. These findings provide a rational basis for the design of MPC-based electrodes in high performance supercapacitors.

The effect of chemical vapor deposition temperature on the performance of binder-free sewage sludge-derived anodes in microbial fuel cells.

PubMed

Feng, Huajun; Jia, Yufeng; Shen, Dongsheng; Zhou, Yuyang; Chen, Ting; Chen, Wei; Ge, Zhipeng; Zheng, Shuting; Wang, Meizhen

2018-04-13

Conversion of sewage sludge (SS) into value-added material has garnered increasing attention due to its potential applications. In this study, we propose a new application of the sewage sludge-derived carbon (SSC) as an electrode without binder in microbial fuel cells (MFCs). SS was firstly converted into SSC monoliths by methane chemical vapor method at different temperature (600, 800, 1000 or 1200°C). Scanning electron microscopy images showed that carbon micro-wires were present on the surfaces of the samples prepared at 1000 and 1200°C. The results showed that it was beneficial for converting sludge into a highly conductive electrode and increasing carbon content of the electrode at higher temperatures, thereby improving the current generation. The conductivity results show that a higher temperature favors the conversion of sludge into a highly conductive electrode. The MFC using an SSC anode processed at 1200°C generated the maximum power density of 2228mWm -2 and the maximum current density of 14.2Am -2 . This value was 5 times greater than that generated by an MFC equipped with a graphite anode. These results present a promising means of converting SS into electrode materials. Copyright © 2018 Elsevier B.V. All rights reserved.

The effect of crumb rubber particle size to the optimum binder content for open graded friction course.

PubMed

Ibrahim, Mohd Rasdan; Katman, Herda Yati; Karim, Mohamed Rehan; Koting, Suhana; Mashaan, Nuha S

2014-01-01

The main objective of this paper is to investigate the relations of rubber size, rubber content, and binder content in determination of optimum binder content for open graded friction course (OGFC). Mix gradation type B as specified in Specification for Porous Asphalt produced by the Road Engineering Association of Malaysia (REAM) was used in this study. Marshall specimens were prepared with four different sizes of rubber, namely, 20 mesh size [0.841 mm], 40 mesh [0.42 mm], 80 mesh [0.177 mm], and 100 mesh [0.149 mm] with different concentrations of rubberised bitumen (4%, 8%, and 12%) and different percentages of binder content (4%-7%). The appropriate optimum binder content is then selected according to the results of the air voids, binder draindown, and abrasion loss test. Test results found that crumb rubber particle size can affect the optimum binder content for OGFC.

Influence of solidification accelerators on structure formation of anhydrite-containing binders

NASA Astrophysics Data System (ADS)

Anikanova, L.; Volkova, O.; Kudyakov, A.; Sarkisov, Y.; Tolstov, D.

2016-01-01

The article presents results of scientific analysis of chemical additives influence on acid fluoride binder. It was found that the influence of sulfate nature additives on the process of hydration and solidification of the binder is similar to influence of additives on indissoluble anhydrite. Additives with SO42- anion NO- are more efficient. The mentioned additives according to accelerating effect belong to the following succession: K2SO4 > Na2SO4 > FeSO4 > MgSO4. Facilitation of the process of hydration and solidification of the binder, increase in density and durability of the binder (32 MPa) is to the greatest extent achieved with the introduction of 2% sodium sulfate additive of the binder's mass into the composition of the binder along with the ultrasonic treatment of water solution. Directed crystal formation process with healing of porous structure by new growths presented as calcium sulfate dehydrate and hydroglauberite provides positive effect.

Comparison of influence of ageing on low-temperature characteristics of asphalt mixtures

NASA Astrophysics Data System (ADS)

Vacková, Pavla; Valentin, Jan; Benešová, Lucie

2017-09-01

Ability of relaxation of asphalt mixtures and thus its resilience to climate change and traffic load is decreasing by influence of aging - in this case aging of bituminous binder. Binder exposed to climate and UV ages and becomes more fragile and susceptible to damage. The results of the research presented in this paper are aimed to finding a correlation between low-temperature properties of referential and aged asphalt mixture specimens and characteristics (not low-temperature) of bituminous binders. In this research there were used conventional road binders, commonly used modified binders and binders additionally modified in the laboratory. The low-temperature characteristics were determined by strength flexural test, commonly used in the Czech Republic for High Modulus Asphalt Mixtures (TP 151), and semi-cylindrical bending test (EN 12697-44). Both of the tests were extended by specimens exposed to artificial long-term aging (EN 12697-52) - storing at 85° C for 5 days. The results were compared with characteristics of binders for finding a suitable correlation between characteristics of binders and asphalt mixtures.

Sustainable asphalt pavement: Application of slaughterhouse waste oil and fly ash in asphalt binder

NASA Astrophysics Data System (ADS)

Sanchez Ramos, Jorge Luis

Increasing energy costs, lack of sufficient natural resources and the overwhelming demand for petroleum has stimulated the development of alternative binders to modify or replace petroleum-based asphalt binders. In the United States, the petroleum-based asphalt binder is mainly used to produce the Hot Mix Asphalt (HMA). There are approximately 4000 asphalt plants that make 500 million tons of asphalt binder valued at roughly 3 billion/year. The instability of the world's oil market has pushed oil prices to more than 80 per barrel in 2012, which increased the cost of asphalt binder up to $570 per ton. Therefore, there is a timely need to find alternative sustainable resources to the asphalt binder. This paper investigates the possibility of the partial replacement of the asphalt binder with slaughterhouse waste and/or fly ash. In order to achieve this objective, the asphalt binder is mixed with different percentages of waste oil and/or fly ash. In order to investigate the effect of these additives to the performance of the asphalt binder, a complete performance grade test performed on multiple samples. The results of the performance grade tests are compared with a control sample to observe how the addition of the waste oil and/or fly ash affects the sample. Considering the increasing cost and demand of asphalt, the use of slaughterhouse waste oil and/or fly ash as a partial replacement may result in environmental and monetary improvements in the transportation sector.

Evaluation of moisture-induced damage of dense graded and gap graded asphalt mixture with nanopolymer modified binder

NASA Astrophysics Data System (ADS)

Shaffie, E.; Arshad, A. K.; Ahmad, J.; Hashim, W.

2018-04-01

The purpose of this research is to study the moisture induce damage performance of dense graded (AC14) and stone mastic asphalt (SMA14) asphalt pavement using Nanolyacrylate polymer modified asphalt binder. The physical properties of aggregate, volumetric and performance of asphalt mixes were assessed and evaluated with the laboratory tests. The study investigates fourteenth different asphalt mixtures consisting of NP modified asphalt binder formulations at 2%, 4% and 6%. Two types of asphalt binder, penetration grade PEN 80-100 and performance grade PG 76 were added with Nanopolyacrylate as asphalt modifier. The modified asphalt binder was prepared by adding 6 percent of Nanopolyacrylate (NP) to the asphalt binder. Both AC14 and SMA14 mixtures passed the Marshall requirements which indicate that these mixtures were good with respect to durability and flexibility. In terms of moisture induce damage, it was observed that the strength of the asphalt mixes increased with the addition of NP polymer modified asphalt binder. Similar trend could also be seen for SMA14 mixes, where the ITS value of SMA14 showed a significant difference compared to AC14 and all the mixtures exceeded the minimum requirement value as specified in the specification. Thus, addition of nanopolyacrylate polymer to the asphalt binder has significantly improved the cohesion as well as adhesion properties of the asphalt binder, and hence the stripping performance. Therefore, it can be concluded that the nanopolyacylate is suitable to be used as a modifier to the modified asphalt binder in order to enhance the properties of the asphalt binder and thus improving the performance of asphalt in both AC14 and SMA14 mixes.

Do aluminium-based phosphate binders continue to have a role in contemporary nephrology practice?

PubMed

Mudge, David W; Johnson, David W; Hawley, Carmel M; Campbell, Scott B; Isbel, Nicole M; van Eps, Carolyn L; Petrie, James J B

2011-05-13

Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports of aluminium related neurological and bone disease began to appear. Available historical evidence however, suggests that neurological toxicity may have primarily been caused by excessive exposure to aluminium in dialysis fluid, rather than aluminium-containing oral phosphate binders. Limited evidence suggests that aluminium bone disease may also be on the decline in the era of aluminium removal from dialysis fluid, even with continued use of aluminium binders. The K/DOQI and KDIGO guidelines both suggest avoiding aluminium-containing binders. These guidelines will tend to promote the use of the newer, more expensive binders (lanthanum, sevelamer), which have limited evidence for benefit and, like aluminium, limited long-term safety data. Treating hyperphosphatemia in dialysis patients continues to represent a major challenge, and there is a large body of evidence linking serum phosphate concentrations with mortality. Most nephrologists agree that phosphate binders have the potential to meaningfully reduce mortality in dialysis patients. Aluminium is one of the cheapest, most effective and well tolerated of the class, however there are no prospective or randomised trials examining the efficacy and safety of aluminium as a binder. Aluminium continues to be used as a binder in Australia as well as some other countries, despite concern about the potential for toxicity. There are some data from selected case series that aluminium bone disease may be declining in the era of reduced aluminium content in dialysis fluid, due to rigorous water testing. This paper seeks to revisit the contemporary evidence for the safety record of aluminium-containing binders in dialysis patients. It puts their use into the context of the newer, more expensive binders and increasing concerns about the risks of calcium binders, which continue to be widely used. The paper seeks to answer whether the continued use of aluminium is justifiable in the absence of prospective data establishing its safety, and we call for prospective trials to be conducted comparing the available binders both in terms of efficacy and safety. © 2011 Mudge et al; licensee BioMed Central Ltd.

The use of abdominal binders to treat over-shunting headaches.

PubMed

Sklar, Frederick H; Nagy, Laszlo; Robertson, Brian D

2012-06-01

Headaches are common in children with shunts. Headaches associated with over-shunting are typically intermittent and tend to occur later in the day. Lying down frequently makes the headaches better. This paper examines the efficacy of using abdominal binders to treat over-shunting headaches. Over an 18-year period, the senior author monitored 1027 children with shunts. Office charts of 483 active patients were retrospectively reviewed to identify those children with headaches and, in particular, those children who were thought to have headaches as a result of over-shunting. Abdominal binders were frequently used to treat children with presumed over-shunting headaches, and these data were analyzed. Of the 483 patients undergoing chart review, 258 (53.4%) had headache. A clinical diagnosis of over-shunting was made in 103 patients (21.3% overall; 39.9% of patients with headache). In 14 patients, the headaches were very mild (1-2 on a 5-point scale) and infrequent (1 or 2 per month), and treatment with an abdominal binder was not thought indicated. Eighty-nine patients were treated with a binder, but 19 were excluded from this retrospective study for noncompliance, interruption of the binder trial, or lack of follow-up. The remaining 70 pediatric patients, who were diagnosed with over-shunting headaches and were treated with abdominal binders, were the subjects of a more detailed retrospective study. Significant headache improvement was observed in 85.8% of patients. On average, the patients wore the binders for approximately 1 month, and headache relief usually persisted even after the binders were discontinued. However, the headaches eventually did recur in many of the patients more than a year later. In these patients, reuse of the abdominal binder was successful in relieving headaches in 78.9%. The abdominal binder is an effective, noninvasive therapy to control over-shunting headaches in most children. This treatment should be tried before any surgery is considered. It is suggested that the abdominal binder may modulate abnormally increased intracranial pulse pressures associated with over-shunting. Interactions with the cerebrovascular bed are suspected to account for persistent headache relief after the binder is discontinued.

Do aluminium-based phosphate binders continue to have a role in contemporary nephrology practice?

PubMed Central

2011-01-01

Background Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports of aluminium related neurological and bone disease began to appear. Available historical evidence however, suggests that neurological toxicity may have primarily been caused by excessive exposure to aluminium in dialysis fluid, rather than aluminium-containing oral phosphate binders. Limited evidence suggests that aluminium bone disease may also be on the decline in the era of aluminium removal from dialysis fluid, even with continued use of aluminium binders. Discussion The K/DOQI and KDIGO guidelines both suggest avoiding aluminium-containing binders. These guidelines will tend to promote the use of the newer, more expensive binders (lanthanum, sevelamer), which have limited evidence for benefit and, like aluminium, limited long-term safety data. Treating hyperphosphatemia in dialysis patients continues to represent a major challenge, and there is a large body of evidence linking serum phosphate concentrations with mortality. Most nephrologists agree that phosphate binders have the potential to meaningfully reduce mortality in dialysis patients. Aluminium is one of the cheapest, most effective and well tolerated of the class, however there are no prospective or randomised trials examining the efficacy and safety of aluminium as a binder. Aluminium continues to be used as a binder in Australia as well as some other countries, despite concern about the potential for toxicity. There are some data from selected case series that aluminium bone disease may be declining in the era of reduced aluminium content in dialysis fluid, due to rigorous water testing. Summary This paper seeks to revisit the contemporary evidence for the safety record of aluminium-containing binders in dialysis patients. It puts their use into the context of the newer, more expensive binders and increasing concerns about the risks of calcium binders, which continue to be widely used. The paper seeks to answer whether the continued use of aluminium is justifiable in the absence of prospective data establishing its safety, and we call for prospective trials to be conducted comparing the available binders both in terms of efficacy and safety. PMID:21569446

Phosphate binder use and mortality among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS): evaluation of possible confounding by nutritional status.

PubMed

Lopes, Antonio Alberto; Tong, Lin; Thumma, Jyothi; Li, Yun; Fuller, Douglas S; Morgenstern, Hal; Bommer, Jürgen; Kerr, Peter G; Tentori, Francesca; Akiba, Takashi; Gillespie, Brenda W; Robinson, Bruce M; Port, Friedrich K; Pisoni, Ronald L

2012-07-01

Poor nutritional status and both hyper- and hypophosphatemia are associated with increased mortality in maintenance hemodialysis (HD) patients. We assessed associations of phosphate binder prescription with survival and indicators of nutritional status in maintenance HD patients. Prospective cohort study (DOPPS [Dialysis Outcomes and Practice Patterns Study]), 1996-2008. 23,898 maintenance HD patients at 923 facilities in 12 countries. Patient-level phosphate binder prescription and case-mix-adjusted facility percentage of phosphate binder prescription using an instrumental-variable analysis. All-cause mortality. Overall, 88% of patients were prescribed phosphate binders. Distributions of age, comorbid conditions, and other characteristics showed small differences between facilities with higher and lower percentages of phosphate binder prescription. Patient-level phosphate binder prescription was associated strongly at baseline with indicators of better nutrition, ie, higher values for serum creatinine, albumin, normalized protein catabolic rate, and body mass index and absence of cachectic appearance. Overall, patients prescribed phosphate binders had 25% lower mortality (HR, 0.75; 95% CI, 0.68-0.83) when adjusted for serum phosphorus level and other covariates; further adjustment for nutritional indicators attenuated this association (HR, 0.88; 95% CI, 0.80-0.97). However, this inverse association was observed for only patients with serum phosphorus levels ≥3.5 mg/dL. In the instrumental-variable analysis, case-mix-adjusted facility percentage of phosphate binder prescription (range, 23%-100%) was associated positively with better nutritional status and inversely with mortality (HR for 10% more phosphate binders, 0.93; 95% CI, 0.89-0.96). Further adjustment for nutritional indicators reduced this association to an HR of 0.95 (95% CI, 0.92-0.99). Results were based on phosphate binder prescription; phosphate binder and nutritional data were cross-sectional; dietary restriction was not assessed; observational design limits causal inference due to possible residual confounding. Longer survival and better nutritional status were observed for maintenance HD patients prescribed phosphate binders and in facilities with a greater percentage of phosphate binder prescription. Understanding the mechanisms for explaining this effect and ruling out possible residual confounding require additional research. Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Toward greener lithium-ion batteries: Aqueous binder-based LiNi0.4Co0.2Mn0.4O2 cathode material with superior electrochemical performance

NASA Astrophysics Data System (ADS)

Chen, Zhen; Kim, Guk-Tae; Chao, Dongliang; Loeffler, Nicholas; Copley, Mark; Lin, Jianyi; Shen, Zexiang; Passerini, Stefano

2017-12-01

This work reports the performance of LiNi0.4Co0.2Mn0.4O2 electrodes employing sodium carboxymethyl cellulose as the binder (CMC/NCM). Compared with conventional organic PVDF-based electrodes, the CMC/NCM electrodes display very uniform distribution of NCM and carbon particles together with strong adhesion among the particles and with the current collector, leading to significantly mitigated crack formation and delamination of the electrode upon repeated delithiation/lithiation processes. Additionally, these electrodes offer enhanced Li+ diffusion kinetics, reduced polarization, therefore, excellent high C-rate capability, and extremely stable cycling performance even at elevated temperature (60 °C). Benefiting from the features of low cost, environmentally friendliness, and easy disposability-recyclability, the water-soluble CMC is a promising binder for practical application in energy storage systems.

Prediction of crosslink density of solid propellant binders. [curing of elastomers

NASA Technical Reports Server (NTRS)

Marsh, H. E., Jr.

1976-01-01

A quantitative theory is outlined which allows calculation of crosslink density of solid propellant binders from a small number of predetermined parameters such as the binder composition, the functionality distributions of the ingredients, and the extent of the curing reaction. The parameter which is partly dependent on process conditions is the extent of reaction. The proposed theoretical model is verified by independent measurement of effective chain concentration and sol and gel fractions in simple compositions prepared from model compounds. The model is shown to correlate tensile data with composition in the case of urethane-cured polyether and certain solid propellants. A formula for the branching coefficient is provided according to which if one knows the functionality distributions of the ingredients and the corresponding equivalent weights and can measure or predict the extent of reaction, he can calculate the branching coefficient of such a system for any desired composition.

The nature of the MDI/wood bond

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marcinko, J.J.; Phanopoulos, C.; Newman, W.H.

1995-12-01

Polymeric diphenylmethane diisocyanate (pMDI) binders have been used in the wood composite industry for 20 years. Almost one half of the oriented strand board (OSB) manufactures in North America are taking advantage of its processing speed and superior board performance. MDI`s current use in Strandboard, MDF (medium density fiber board), LVL (laminated veneer lumber), Plywood, and Particleboard is wide spread. A fundamental understanding of the role of MIDI as a binder in these complex composites is essential for further processing optimization. Experimental data is presented which investigates the nature of the chemical bonding in wood composites. Solid state nuclear magneticmore » resonance (NMR) data is combined with data from thermal analysis and fluorescence microscopy to investigate the chemistry, penetration, and morphology of the isocyanate/wood interphase. Structure property relationships are developed and related to composite performance. The study contrasts isocyanate and phenol formaldehyde binder systems.« less

Clarithromycin highly-loaded gastro-floating fine granules prepared by high-shear melt granulation can enhance the efficacy of Helicobacter pylori eradication.

PubMed

Aoki, Hajime; Iwao, Yasunori; Mizoguchi, Midori; Noguchi, Shuji; Itai, Shigeru

2015-05-01

In an effort to develop a new gastro-retentive drug delivery system (GRDDS) without a large amount of additives, 75% clarithromycin (CAM) loaded fine granules were prepared with three different hydrophobic binders by high-shear melt granulation and their properties were evaluated. Granules containing the higher hydrophobic binder showed sustained drug release and were able to float over 24h. The synchrotron X-ray CT measurement indicated that both the high hydrophobicity of the binder and the void space inside the granules might be involved in their buoyancy. In an in vivo experiment, the floating granules more effectively eradicated Helicobacter pylori than a CAM suspension by remaining in the stomach for a longer period. In short, CAM highly-loaded gastro-floating fine granules can enhance the eradication efficiency of H. pylori compared with CAM alone. Copyright © 2015 Elsevier B.V. All rights reserved.

Theoretical Solution for Temperature Profile in Multi-layered Pavement Systems Subjected to Transient Thermal Loads

DTIC Science & Technology

2011-01-01

kcal/mm s ◦C) Geopolymer paste 2.0x10−7 PCC slab 5.1x10−7 Thermal diffusivity, α (mm2/s) Geopolymer 0.2 PCC slab 1.3 for the surface layer of airfield...concrete pavements. Geopolymer materials have desirable properties for serving as an alternative binder to traditional Portland cement in producing...high thermal stability. Thus it is possible to construct paving concrete made from a geopolymer binder on top of the ordinary concrete slab to limit

Binder-free LiCoO2/carbon nanotube cathodes for high-performance lithium ion batteries.

PubMed

Luo, Shu; Wang, Ke; Wang, Jiaping; Jiang, Kaili; Li, Qunqing; Fan, Shoushan

2012-05-02

Binder-free LiCoO(2) -SACNT cathodes with excellent flexibility and conductivity are obtained by constructing a continuous three-dimensional super-aligned carbon nanotube (SACNT) framework with embedded LiCoO(2) particles. These binder-free cathodes display much better cycling stability, greater rate performance, and higher energy density than classical cathodes with binder. Various functional binder-free SACNT composites can be mass produced by the ultrasonication and co-deposition method described in this paper. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Proton conducting membrane using a solid acid

NASA Technical Reports Server (NTRS)

Haile, Sossina M. (Inventor); Chisholm, Calum (Inventor); Boysen, Dane (Inventor); Narayanan, Sekharipuram R. (Inventor)

2002-01-01

A solid acid material is used as a proton conducting membrane in an electrochemical device. The solid acid material can be one of a plurality of different kinds of materials. A binder can be added, and that binder can be either a nonconducting or a conducting binder. Nonconducting binders can be, for example, a polymer or a glass. A conducting binder enables the device to be both proton conducting and electron conducting. The solid acid material has the general form M.sub.a H.sub.b (XO.sub.t).sub.c.

Predictors of Response and Mechanisms of Change in an Organizational Skills Intervention for Students with ADHD

PubMed Central

Becker, Stephen P.; Epstein, Jeffery N.; Vaughn, Aaron J.; Girio-Herrera, Erin

2013-01-01

The purpose of the study was to evaluate predictors of response and mechanisms of change for the Homework, Organization, and Planning Skills (HOPS) intervention for middle school students with Attention-Deficit/Hyperactivity Disorder (ADHD). Twenty-three middle school students with ADHD (grades 6–8) received the HOPS intervention implemented by school mental health providers and made significant improvements in parent-rated materials organization and planning skills, impairment due to organizational skills problems, and homework problems. Predictors of response examined included demographic and child characteristics, such as gender, ethnicity, intelligence, ADHD and ODD symptom severity, and ADHD medication use. Mechanisms of change examined included the therapeutic alliance and adoption of the organization and planning skills taught during the HOPS intervention. Participant implementation of the HOPS binder materials organization system and the therapeutic alliance as rated by the student significantly predicted post-intervention outcomes after controlling for pre-intervention severity. Adoption of the binder materials organization system predicted parent-rated improvements in organization, planning, and homework problems above and beyond the impact of the therapeutic alliance. These findings demonstrate the importance of teaching students with ADHD to use a structured binder organization system for organizing and filing homework and classwork materials and for transferring work to and from school. PMID:24319323

Reduction of hyperphosphatemia is related with the reduction of C-reactive protein in dialysis patients. Study in sevelamer-resistant dialysis patients treated with chitosan chewing gum as salivary phosphate binder.

PubMed

Calò, Lorenzo A; Savica, Vincenzo; Piccoli, Antonio; Fusaro, Maria; D'Angelo, Angela; Davis, Paul A

2011-01-01

In end-stage renal disease (ESRD) hyperphosphatemia associates with vascular calcifications and cardiovascular events derived from endothelial dysfunction. In dialysis patients, C-reactive protein (CRP), a marker of inflammation, associates with cardiovascular mortality. Increased PO(4) concentration impairs endothelial integrity via induction of oxidative stress, and sevelamer, a phosphate binder, showed anti-inflammatory effect reducing CRP, which paralleled PO(4) reduction. To give support to a direct proinflammatory role of hyperphosphatemia "per se," we have considered previously studied dialysis patients with sevelamer-"resistant" hyperphosphatemia, who were treated with a chitosan-loaded chewing gum, as salivary phosphate binder, in addition to sevelamer, reduced serum PO(4) to normal, to retrospectively evaluate their CRP and the relationship with hyperphosphatemia and calcium × phosphate (Ca × PO(4)) product. High sensitive (hs) CRP of 13 previously studied hemodialysis patients with sevelamer-resistant hyperphosphatemia was evaluated with immunonephelometry. Chitosan chewing gum use reduced hsCRP (from 1.38 ± 0.61 to 0.39 ± 0.16 mg/L after the gum, p < 0.0002), which returned to baseline after 4 weeks from gum discontinuation (1.25 ± 0.41). hsCRP reduction paralleled serum PO(4) reduction: from 7.60 ± 0.91 mg/dL to 5.18 ± 0.73 (after the gum) (p < 0.00001), returning to baseline (7.55 ± 0.75) after gum discontinuation. hsCRP reduction directly correlated with PO(4) reduction (p = 0.029). The relationship in sevelamer-resistant dialysis patients between the reduction of serum PO(4), induced by the chitosan-loaded chewing gum, and CRP reduction supports also in humans a proinflammatory role of hyperphosphatemia "per se" derived from "in vitro" studies. This further contributes to the high cardiovascular risk of ESRD patients making their serum phosphate in the normal range of vital importance.

The Theory and Application of Information and Referral Systems in the University of Maryland Residence Halls

ERIC Educational Resources Information Center

Thoman, Cherie; Moore, Jerry E.

1977-01-01

This resource system consists of eight information and referral centers each housing a resource instrument (binders and flip chart), an operator, outreach staff, one mobile instrument, a systematic updating system and an evaluation system. (Author/DOW)

Characterizing and modeling organic binder burnout from green ceramic compacts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ewsuk, K.G.; Cesarano, J. III; Cochran, R.J.

New characterization and computational techniques have been developed to evaluate and simulate binder burnout from pressed powder compacts. Using engineering data and a control volume finite element method (CVFEM) thermal model, a nominally one dimensional (1-D) furnace has been designed to test, refine, and validate computer models that simulate binder burnout assuming a 1-D thermal gradient across the ceramic body during heating. Experimentally, 1-D radial heat flow was achieved using a rod-shaped heater that directly heats the inside surface of a stack of ceramic annuli surrounded by thermal insulation. The computational modeling effort focused on producing a macroscopic model formore » binder burnout based on continuum approaches to heat and mass conservation for porous media. Two increasingly complex models have been developed that predict the temperature and mass of a porous powder compact as a function of time during binder burnout. The more complex model also predicts the pressure within a powder compact during binder burnout. Model predictions are in reasonably good agreement with experimental data on binder burnout from a 57--65% relative density pressed powder compact of a 94 wt% alumina body containing {approximately}3 wt% binder. In conjunction with the detailed experimental data from the prototype binder burnout furnace, the models have also proven useful for conducting parametric studies to elucidate critical i-material property data required to support model development.« less

Characterization of 27 Mycotoxin Binders and the Relation with in Vitro Zearalenone Adsorption at a Single Concentration

PubMed Central

De Mil, Thomas; Devreese, Mathias; De Baere, Siegrid; Van Ranst, Eric; Eeckhout, Mia; De Backer, Patrick; Croubels, Siska

2015-01-01

The aim of this study was to characterize 27 feed additives marketed as mycotoxin binders and to screen them for their in vitro zearalenone (ZEN) adsorption. Firstly, 27 mycotoxin binders, commercially available in Belgium and The Netherlands, were selected and characterized. Characterization was comprised of X-ray diffraction (XRD) profiling of the mineral content and d-spacing, determination of the cation exchange capacity (CEC) and the exchangeable base cations, acidity, mineral fraction, relative humidity (RH) and swelling volume. Secondly, an in vitro screening experiment was performed to evaluate the adsorption of a single concentration of ZEN in a ZEN:binder ratio of 1:20,000. The free concentration of ZEN was measured after 4 h of incubation with each of the 27 mycotoxin binders at a pH of 2.5, 6.5 and 8.0. A significant correlation between the free concentration of ZEN and both the d-spacing and mineral fraction of the mycotoxin binders was seen at the three pH levels. A low free concentration of ZEN was demonstrated using binders containing mixed-layered smectites and binders containing humic acids. PMID:25568976

The impact of nurse-led education on haemodialysis patients' phosphate binder medication adherence.

PubMed

Sandlin, Kimberly; Bennett, Paul N; Ockerby, Cherene; Corradini, Ann-Marie

2013-03-01

Phosphate binder medication adherence is required to maintain optimal phosphate levels and minimise bone disease in people with end stage kidney disease. To examine the impact of a nurse-led education intervention on bone disorder markers, adherence to phosphate binder medication and medication knowledge. Descriptive study with a paired pre-post intervention survey. Adults receiving haemodialysis. Twelve-week intervention where patients self-administered their phosphate binder medication at each dialysis treatment. Nurses provided individualised education. Patients completed a pre- and post-intervention survey designed to explore their knowledge of phosphate binders. There were no statistically significant changes in clinical markers but a significant improvement in the proportion of patients who took their phosphate binder correctly, increasing from 44 to 72% (p = 0.016). There were moderate to large effect size changes for improved knowledge. A nurse-led intervention education programme can increase patients' phosphate binder adherence. However, this does not necessarily manifest into improved serum phosphate levels. © 2013 European Dialysis and Transplant Nurses Association/European Renal Care Association.

The Effect of Crumb Rubber Particle Size to the Optimum Binder Content for Open Graded Friction Course

PubMed Central

Ibrahim, Mohd Rasdan; Katman, Herda Yati; Karim, Mohamed Rehan; Koting, Suhana; Mashaan, Nuha S.

2014-01-01

The main objective of this paper is to investigate the relations of rubber size, rubber content, and binder content in determination of optimum binder content for open graded friction course (OGFC). Mix gradation type B as specified in Specification for Porous Asphalt produced by the Road Engineering Association of Malaysia (REAM) was used in this study. Marshall specimens were prepared with four different sizes of rubber, namely, 20 mesh size [0.841 mm], 40 mesh [0.42 mm], 80 mesh [0.177 mm], and 100 mesh [0.149 mm] with different concentrations of rubberised bitumen (4%, 8%, and 12%) and different percentages of binder content (4%–7%). The appropriate optimum binder content is then selected according to the results of the air voids, binder draindown, and abrasion loss test. Test results found that crumb rubber particle size can affect the optimum binder content for OGFC. PMID:24574875

Effect of Different Binders on the Electrochemical Performance of Metal Oxide Anode for Lithium-Ion Batteries

NASA Astrophysics Data System (ADS)

Wang, Rui; Feng, Lili; Yang, Wenrong; Zhang, Yinyin; Zhang, Yanli; Bai, Wei; Liu, Bo; Zhang, Wei; Chuan, Yongming; Zheng, Ziguang; Guan, Hongjin

2017-10-01

When testing the electrochemical performance of metal oxide anode for lithium-ion batteries (LIBs), binder played important role on the electrochemical performance. Which binder was more suitable for preparing transition metal oxides anodes of LIBs has not been systematically researched. Herein, five different binders such as polyvinylidene fluoride (PVDF) HSV900, PVDF 301F, PVDF Solvay5130, the mixture of styrene butadiene rubber and sodium carboxymethyl cellulose (SBR+CMC), and polyacrylonitrile (LA133) were studied to make anode electrodes (compared to the full battery). The electrochemical tests show that using SBR+CMC and LA133 binder which use water as solution were significantly better than PVDF. The SBR+CMC binder remarkably improve the bonding capacity, cycle stability, and rate performance of battery anode, and the capacity retention was about 87% after 50th cycle relative to the second cycle. SBR+CMC binder was more suitable for making transition metal oxides anodes of LIBs.

Method for the production of cementitious compositions and aggregate derivatives from said compositions, and cementitious compositions and aggregates produced thereby

DOEpatents

Minnick, L. John

1983-01-01

The present invention relates to a method for preparing synthetic shaped cementitious compositions having high quality even without the addition of high energy binders, such as portland cement, through the use of the spent residue from a fluidized combustion bed of the type wherein limestone particles are suspended in a fluidized medium and sulfur oxides are captured, and pulverized coal fly ash.

On The Development of Additive Construction Technologies for Application to Development of Lunar/Martian Surface Structures Using In-Situ Materials

NASA Technical Reports Server (NTRS)

Werkheiser, Niki; Fiske, Michael; Edmunson, Jennifer; Khoshnevis, Behrokh

2015-01-01

For long-duration missions on other planetary bodies, the use of in-situ materials will become increasingly critical. As man's presence on these bodies expands, so must the breadth of the structures required to accommodate them including habitats, laboratories, berms, radiation shielding for natural radiation and surface reactors, garages, solar storm shelters, greenhouses, etc. Planetary surface structure manufacturing and assembly technologies that incorporate in-situ resources provide options for autonomous, affordable, pre-positioned environments with radiation shielding features and protection from micrometeorites, exhaust plume debris, and other hazards. This is important because gamma and particle radiation constitute a serious but reducible threat to long-term survival of human beings, electronics, and other materials in space environments. Also, it is anticipated that surface structures will constitute the primary mass element of lunar or Martian launch requirements. The ability to use in-situ materials to construct these structures will provide a benefit in the reduction of up-mass that would otherwise make long-term Moon or Mars structures cost prohibitive. The ability to fabricate structures in situ brings with it the ability to repair these structures, which allows for self-sufficiency necessary for long-duration habitation. Previously, under the auspices of the MSFC In Situ Fabrication and Repair (ISFR) project and more recently, under the joint MSFC/KSC Additive Construction with Mobile Emplacement (ACME) project, the MSFC Surface Structures Group has been developing materials and construction technologies to support future planetary habitats with in situ resources. One such technology, known as Contour Crafting (additive construction), is shown in Figure 1, along with a typical structure fabricated using this technology. This paper will present the results to date of these efforts, including development of novel nozzle concepts for advanced layer deposition using the Contour Crafting process. This process, conceived initially for rapid development of cementitious structures on Earth, also lends itself exceptionally well to the automated fabrication of planetary surface structures using minimally processed regolith as aggregate, and imported binder material or binders developed from in situ materials. This process has been used successfully in the fabrication of construction elements using lunar regolith simulant and Mars regolith simulant, both with various binder materials. These binder materials have resulted from extensive evaluation and include both "imported" binder materials that might be launched from Earth as well as some binder materials that can theoretically also be derived from existing regolith materials. They were chosen to 1) reduce penetrating radiation as much as possible, primarily with hydrogen-bearing polymers, 2) attempt to provide an air-tight structure, 3) sufficiently mix and adsorb to regolith grains for strength, 4) maximize tolerance to day-night thermal cycling, 5) possibly increase electrical conductivity to dissipate any accumulated static charge, and 6) ease their application on planetary surfaces (specifically, the accommodation of reduced atmosphere and lack of heat sinks). Some of these materials have been tested with respect to radiation mitigation, micrometeorite resistance, and resistance to larger, slower-traveling pieces of regolith impinging on the surface, simulating nearby launch and landing activities. Conceptual designs for a Continuous Feedstock Delivery/Mixing System (CFDMS) will also be presented and future planned activities will be discussed as well.

40 CFR 63.1381 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... wool fiberglass to which a phenol-formaldehyde binder has been applied. Building insulation means bonded wool fiberglass insulation, having a loss on ignition of less than 8 percent and a density of less... charger systems, heat exchangers, melter cooling system, exhaust system, refractory brick work, fuel...

40 CFR 63.1381 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... wool fiberglass to which a phenol-formaldehyde binder has been applied. Building insulation means bonded wool fiberglass insulation, having a loss on ignition of less than 8 percent and a density of less... charger systems, heat exchangers, melter cooling system, exhaust system, refractory brick work, fuel...

Metal-phosphate binders

DOEpatents

Howe, Beth Ann [Lewistown, IL; Chaps-Cabrera, Jesus Guadalupe [Coahuila, MX

2009-05-12

A metal-phosphate binder is provided. The binder may include an aqueous phosphoric acid solution, a metal-cation donor including a metal other than aluminum, an aluminum-cation donor, and a non-carbohydrate electron donor.

Correlated Time-Variation of Asphalt Rheology and Bulk Microstructure

NASA Astrophysics Data System (ADS)

Ramm, Adam; Nazmus, Sakib; Bhasin, Amit; Downer, Michael

We use noncontact optical microscopy and optical scattering in the visible and near-infrared spectrum on Performance Grade (PG) asphalt binder to confirm the existence of microstructures in the bulk. The number of visible microstructures increases linearly as penetration depth of the incident radiation increases, which verifies a uniform volume distribution of microstructures. We use dark field optical scatter in the near-infrared to measure the temperature dependent behavior of the bulk microstructures and compare this behavior with Dynamic Shear Rheometer (DSR) measurements of the bulk complex shear modulus | G* (T) | . The main findings are: (1) After reaching thermal equilibrium, both temperature dependent optical scatter intensity (I (T)) and bulk shear modulus (| G* (T) |) continue to change appreciably for times much greater than thermal equilibration times. (2) The hysteresis behavior during a complete temperature cycle seen in previous work derives from a larger time dependence in the cooling step compared with the heating step. (3) Different binder aging conditions show different thermal time-variations for both I (T) and | G* (T) | .

A smart approach to add antibacterial functionality to cellulosic pigment prints.

PubMed

Ibrahim, N A; Eid, B M; Elmaaty, T M Abou; El-Aziz, E Abd

2013-04-15

This study was devoted to enhancing the antibacterial functionality of pigment printed cotton, linen and viscose fabrics. Ag-NP's/PVP colloid, triclosan derivatives, chitosan or choline chloride was successfully incorporated into the pigment paste followed by printing and microwave curing to impart antibacterial activity to the cellulosic prints. Results obtained demonstrate that the modified pigment prints exhibit a remarkable antibacterial activity against the G+ve (Staphylococcus aureus) and G-ve (Escherichia coli) bacteria with a noticeable durability after 20 washing cycles without adversely affecting the printing and softness properties. The extent of printability and functionality of the nominated substrates are significantly governed by the type of: bio-active ingredient, binder, pigment and substrate. TEM, SEM and EDX analysis confirmed the formation of Ag-NP's/PVP colloid, of particle size range 7-14 nm, deposition of cross-linked-binder film onto the modified pigment prints, and the existence of elementary Ag and Si loaded onto fabrics surface, respectively. Copyright © 2013 Elsevier Ltd. All rights reserved.

Study the bonding mechanism of binders on hydroxyapatite surface and mechanical properties for 3DP fabrication bone scaffolds.

PubMed

Wei, Qinghua; Wang, Yanen; Li, Xinpei; Yang, Mingming; Chai, Weihong; Wang, Kai; zhang, Yingfeng

2016-04-01

In 3DP fabricating artificial bone scaffolds process, the interaction mechanism between binder and bioceramics power determines the microstructure and macro mechanical properties of Hydroxyapatite (HA) bone scaffold. In this study, we applied Molecular Dynamics (MD) methods to investigating the bonding mechanism and essence of binders on the HA crystallographic planes for 3DP fabrication bone scaffolds. The cohesive energy densities of binders and the binding energies, PCFs g(r), mechanical properties of binder/HA interaction models were analyzed through the MD simulation. Additionally, we prepared the HA bone scaffold specimens with different glues by 3DP additive manufacturing, and tested their mechanical properties by the electronic universal testing machine. The simulation results revealed that the relationship of the binding energies between binders and HA surface is consistent with the cohesive energy densities of binders, which is PAM/HA>PVA/HA>PVP/HA. The PCFs g(r) indicated that their interfacial interactions mainly attribute to the ionic bonds and hydrogen bonds which formed between the polar atoms, functional groups in binder polymer and the Ca, -OH in HA. The results of mechanical experiments verified the relationship of Young׳s modulus for three interaction models in simulation, which is PVA/HA>PAM/HA>PVP/HA. But the trend of compressive strength is PAM/HA>PVA/HA>PVP/HA, this is consistent with the binding energies of simulation. Therefore, the Young׳s modulus of bone scaffolds are limited by the Young׳s modulus of binders, and the compressive strength is mainly decided by the viscosity of binder. Finally, the major reasons for differences in mechanical properties between simulation and experiment were found, the space among HA pellets and the incomplete infiltration of glue were the main reasons influencing the mechanical properties of 3DP fabrication HA bone scaffolds. These results provide useful information in choosing binder for 3DP fabrication bone scaffolds and understanding the interaction mechanism between binder and HA bioceramics power. Copyright © 2015 Elsevier Ltd. All rights reserved.

Effect of dietary supplementation with clay-based binders on biochemical and histopathological changes in organs of turkey fed with aflatoxin-contaminated diets.

PubMed

Lala, A O; Ajayi, O L; Oso, A O; Ajao, M O; Oni, O O; Okwelum, N; Idowu, O M O

2016-12-01

This study was carried out to investigate the effect of dietary supplementation with molecular or nano-clay binders on biochemical and histopathological examination of organs of turkeys fed diets contaminated with aflatoxin B 1. Two hundred and sixteen unsexed 1-day-old British United Turkeys were randomly allotted to nine diets in a 3 × 3 factorial arrangement of diets supplemented with no toxin binder, molecular toxin binder (MTB) and nano-clay toxin binder, each contaminated with 0, 60 and 110 ppb aflatoxin B 1 respectively. There were three replicates per treatment with eight turkeys per replicate. Biochemical analyses, organ weights and histopathological changes of some organs were examined at the end of the study which lasted for 84 days. Turkeys fed diets supplemented with molecular and nano-binders showed higher (p < 0.001) total serum protein, reduced (p < 0.001) serum uric acid and GGT concentration values when compared with those fed aflatoxin-contaminated diets supplemented with no binder. Turkeys fed aflatoxin-contaminated diets supplemented with no binder had increased (p < 0.001) AST and ALT concentration when compared with other treatments. The heaviest (p < 0.001) liver and intestinal weight was noticed with turkeys fed diets supplemented with no binder and contaminated with 110 ppb aflatoxin B 1 . Pathologically, there was no visible morphological alteration noticed in all turkeys fed uncontaminated diets and nano-clay-supplemented group. Hepatic paleness, hepatomegaly and yellowish discolouration of the liver were observed with turkeys fed diets containing no binder but contaminated with 60 and 110 ppb aflatoxin B1. Intestinal histopathological changes such as goblet cell hyperplasia, villous atrophy and diffuse lymphocytic enteritis were more prominent in turkeys fed diets containing no toxin binder and MTB. In conclusion, there were improved biochemical parameters and reduced deleterious effects of aflatoxin B 1 in turkeys fed diet supplemented with clay binders. However, the improvement was more conspicuous in the nano-clay-supplemented group than molecular clay group. Journal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbH.

High capacity Li-ion battery anodes: Impact of crystallite size, surface chemistry and PEG-coating

DOE PAGES

Minnici, Krysten; Kwon, Yo Han; Huie, Matthew M.; ...

2017-12-06

Battery electrodes are complex mesoscale systems comprised of an active material, conductive agent, current collector, and polymeric binder. Previous work showed that introduction of poly [3-(potassium-4-butanoate) thiophene] (PPBT) as a binder component coupled with a polyethylene glycol (PEG) surface coating on magnetite (Fe 3O 4) nanoparticles enhanced electron and ion transport in the high capacity anode system. Here, the impact of Fe 3O 4 crystallite size (10 nm vs. 20 nm) and surface chemistry were explored to evaluate their effects on interfacial interactions within the composite PEG/PPBT based electrodes and resultant battery performance. The Fe 3O 4 synthesis methods inevitablymore » lead to differences in surface chemistry. For instance, the Fe 3O 4 particles synthesized using ammonium hydroxide appeared more dispersed, and afforded improved rate capability performance. Notably, chemical interactions between the active nanoparticles and PPBT binder were only seen with particles synthesized using triethylamine. Capacity retention and cycling performance were unaffected. Thus, this study provides fundamental insights into the significant impact of active material synthesis on the design and fabrication of composite battery electrodes.« less

High capacity Li-ion battery anodes: Impact of crystallite size, surface chemistry and PEG-coating

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minnici, Krysten; Kwon, Yo Han; Huie, Matthew M.

Battery electrodes are complex mesoscale systems comprised of an active material, conductive agent, current collector, and polymeric binder. Previous work showed that introduction of poly [3-(potassium-4-butanoate) thiophene] (PPBT) as a binder component coupled with a polyethylene glycol (PEG) surface coating on magnetite (Fe 3O 4) nanoparticles enhanced electron and ion transport in the high capacity anode system. Here, the impact of Fe 3O 4 crystallite size (10 nm vs. 20 nm) and surface chemistry were explored to evaluate their effects on interfacial interactions within the composite PEG/PPBT based electrodes and resultant battery performance. The Fe 3O 4 synthesis methods inevitablymore » lead to differences in surface chemistry. For instance, the Fe 3O 4 particles synthesized using ammonium hydroxide appeared more dispersed, and afforded improved rate capability performance. Notably, chemical interactions between the active nanoparticles and PPBT binder were only seen with particles synthesized using triethylamine. Capacity retention and cycling performance were unaffected. Thus, this study provides fundamental insights into the significant impact of active material synthesis on the design and fabrication of composite battery electrodes.« less

Effect of different binders on the physico-chemical, textural, histological, and sensory qualities of retort pouched buffalo meat nuggets.

PubMed

Devadason, I Prince; Anjaneyulu, A S R; Babji, Y

2010-01-01

The functional properties of 4 binders, namely corn starch, wheat semolina, wheat flour, and tapioca starches, were evaluated to improve the quality of buffalo meat nuggets processed in retort pouches at F(0) 12.13. Incorporation of corn starch in buffalo meat nuggets produced more stable emulsion than other binders used. Product yield, drip loss, and pH did not vary significantly between the products with different binders. Shear force value was significantly higher for product with corn starch (0.42 +/- 0.0 Kg/cm(3)) followed by refined wheat flour (0.36 +/- 0.010 Kg/cm(3)), tapioca starch (0.32 +/- 0.010 Kg/cm(3)), and wheat semolina (0.32 +/- 0.010 Kg/cm(3)). Type of binder used had no significant effect on frying loss, moisture, and protein content of the product. However, fat content was higher in products with corn starch when compared to products with other binders. Texture profile indicated that products made with corn starch (22.17 +/- 2.55 N) and refined wheat flour (21.50 +/- 0.75 N) contributed firmer texture to the product. Corn starch contributed greater chewiness (83.8 +/- 12.51) to the products resulting in higher sensory scores for texture and overall acceptability. Products containing corn starch showed higher sensory scores for all attributes in comparison to products with other binders. Panelists preferred products containing different binders in the order of corn starch (7.23 +/- 0.09) > refined wheat flour (6.48 +/- 0.13) > tapioca starch (6.45 +/- 0.14) > wheat semolina (6.35 +/- 0.13) based on sensory scores. Histological studies indicated that products with corn starch showed dense protein matrix, uniform fat globules, and less number of vacuoles when compared to products made with other binders. The results indicated that corn flour is the better cereal binder for developing buffalo meat nuggets when compared to all other binders based on physico-chemical and sensory attributes.

Influence of pH on in vitro disintegration of phosphate binders.

PubMed

Stamatakis, M K; Alderman, J M; Meyer-Stout, P J

1998-11-01

Hyperphosphatemia, a common complication in patients with end-stage renal disease, is treated with oral phosphate-binding medications that restrict phosphorus absorption from the gastrointestinal (GI) tract. Impaired product performance, such as failure to disintegrate and/or dissolve in the GI tract, could limit the efficacy of the phosphate binder. Disintegration may be as important as dissolution for predicting in vitro product performance for medications that act locally on the GI tract, such as phosphate binders. Furthermore, patients with end-stage renal disease have a wide range in GI pH, and pH can influence a product's performance. The purpose of this study was to determine the effect of pH on in vitro disintegration of phosphate binders. Fifteen different commercially available phosphate binders (seven calcium carbonate tablet formulations, two calcium acetate tablet formulations, three aluminum hydroxide capsule formulations, and three aluminum hydroxide tablet formulations) were studied using the United States Pharmacopeia (USP) standard disintegration apparatus. Phosphate binders were tested in simulated gastric fluid (pH 1.5), distilled water (pH 5.1), and simulated intestinal fluid (pH 7.5). Product failure was defined as two or more individual tablets or capsules failing to disintegrate completely within 30 minutes. Results indicate that 9 of the 15 phosphate binders tested showed statistically significant differences in disintegration time (DT) based on pH. The percentage of binders that passed the disintegration study test in distilled water, gastric fluid, and intestinal fluid were 80%, 80%, and 73%, respectively. The findings of this study show that the disintegration of commercially available phosphate binders is highly variable. The pH significantly affected in vitro disintegration in the majority of phosphate binders tested; how significantly this affects in vivo performance has yet to be studied.

Capabilities and limitations of handheld Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) for the analysis of colourants and binders in 20th-century reverse paintings on glass

NASA Astrophysics Data System (ADS)

Steger, Simon; Stege, Heike; Bretz, Simone; Hahn, Oliver

2018-04-01

A non-invasive method has been carried out to show the capabilities and limitations of Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) for identifying of colourants and binders in modern reverse glass paintings. For this purpose, the reverse glass paintings "Zwei Frauen am Tisch" (1920-22), "Bäume" (1946) (both by Heinrich Campendonk), "Lofoten" (1933) (Edith Campendonk-van Leckwyck) and "Ohne Titel" (1954) (Marianne Uhlenhuth), were measured. In contrast to other techniques (e.g. panel and mural painting), the paint layers are applied in reverse succession. In multi-layered paint systems, the front paint layer may no longer be accessible. The work points out the different spectral appearance of a given substance (gypsum, basic lead white) in reverse glass paintings. However, inverted bands, band overlapping and derivative-shaped spectral features can be interpreted by comparing the spectra from the paintings with spectra from pure powders and pigment/linseed oil mock-ups. Moreover, the work focuses on this method's capabilities in identifying synthetic organic pigments (SOP). Reference spectra of three common SOP (PG7, PY1, PR83) were obtained from powders and historical colour charts. We identified PR83 and PY1 in two reverse glass paintings, using the measured reference spectra. The recorded DRIFTS spectra of pure linseed oil, gum Arabic, mastic, polyvinyl acetate resin and bees wax can be used to classify the binding media of the measured paintings.

Development of a Rapid Identification Method for a Variety of Antibody Candidates Using High-throughput Sequencing.

PubMed

Ito, Yuji

2017-01-01

As an alternative to hybridoma technology, the antibody phage library system can also be used for antibody selection. This method enables the isolation of antigen-specific binders through an in vitro selection process known as biopanning. While it has several advantages, such as an avoidance of animal immunization, the phage cloning and screening steps of biopanning are time-consuming and problematic. Here, we introduce a novel biopanning method combined with high-throughput sequencing (HTS) using a next-generation sequencer (NGS) to save time and effort in antibody selection, and to increase the diversity of acquired antibody sequences. Biopannings against a target antigen were performed using a human single chain Fv (scFv) antibody phage library. VH genes in pooled phages at each round of biopanning were analyzed by HTS on a NGS. The obtained data were trimmed, merged, and translated into amino acid sequences. The frequencies (%) of the respective VH sequences at each biopanning step were calculated, and the amplification factor (change of frequency through biopanning) was obtained to estimate the potential for antigen binding. A phylogenetic tree was drawn using the top 50 VH sequences with high amplification factors. Representative VH sequences forming the cluster were then picked up and used to reconstruct scFv genes harboring these VHs. Their derived scFv-Fc fusion proteins showed clear antigen binding activity. These results indicate that a combination of biopanning and HTS enables the rapid and comprehensive identification of specific binders from antibody phage libraries.

Seal coat binder performance specifications.

DOT National Transportation Integrated Search

2013-11-01

Need to improve seal coat binder specs: replace empirical tests (penetration, ductility) with : performance-related tests applicable to both : unmodified and modified binders; consider temperatures that cover entire in service : range that are tied t...

Polysiloxane binder for lithium ion battery electrodes

DOEpatents

Zhang, Zhengcheng; Dong, Jian; Amine, Khalil

2015-10-13

An electrode includes a binder and an electroactive material, wherein the binder includes a polymer including a linear polysiloxane or a cyclic polysiloxane. The polymer may be generally represented by Formula I: ##STR00001##

Practical experiences with new types of highly modified asphalt binders

NASA Astrophysics Data System (ADS)

Špaček, Petr; Hegr, Zdeněk; Beneš, Jan

2017-09-01

As a result of steadily increasing traffic load on the roads in the Czech Republic, we should be focused on the innovative technical solutions, which will lead to extending the life time of asphalt pavements. One of these ways could be the future use of bitumen with a higher degree of polymer modification. This paper discusses experience with comparison of new highly polymer modified asphalt binder type with conventional polymer modified asphalt binder and unmodified binder with penetration grade 50/70. There are compared the results of various types laboratory tests of asphalt binders, as well as the results of asphalt mixtures laboratory tests. The paper also mentions the experience with workability and compactability of asphalt mixture with highly polymer modified asphalt binder during the realization of the experimental reference road section by the Skanska company in the Czech Republic.

The influence of metakaolin substitution by slag in alkali-activated inorganic binders for civil engineering

NASA Astrophysics Data System (ADS)

Kadlec, J.; Rieger, D.; Kovářík, T.; Novotný, P.; Franče, P.; Pola, M.

2017-02-01

In this study the effect of metakaolin replacement by milled blast furnace slag in alkali-activated geopolymeric binder was investigated in accordance to their rheological and mechanical properties. It was demonstrated that slag addition into the metakaolin binder can improve mechanical properties of final products. Our investigation was focused on broad interval of metakaolin substitution in the range from 100 to 40 volume per cents of metakaolin so that the volume content of solids in final binder was maintained constant. Prepared binders were activated by alkaline solution of potassium silicate with silicate module of 1.61. The particle size analyses were performed for determination of particle size distribution. The rheological properties were determined in accordance to flow properties by measurements on Ford viscosity cup and by oscillatory measurements of hardening process. For the investigation of hardening process, the strain controlled small amplitude oscillatory rheometry was used in plane-plate geometry. For determination of applied mechanical properties were binders filled by ceramic grog in the granularity range 0-1 mm. The filling was maintained constant at 275 volume per cents in accordance to ratio of solids in dry binder. The mechanical properties were investigated after 1, 7 and 28 days and microstructure was documented by scanning electron microscopy. The results indicate that slag addition have beneficial effect not only on mechanical properties of hardened binder but also on flow properties of fresh geopolymer paste and subsequent hardening kinetics of alkali-activated binders.

Modified binders on the basis of flotation tailings

NASA Astrophysics Data System (ADS)

Shapovalov, N. A.; Zagorodnyuk, L. Kh; Shchekina, A. Yu; Gorodov, A. I.

2018-03-01

The article proposes compositions of efficient modified composite binders on the basis of portland cement and flotation tailings; the new binders attain the ultimate compressive stress that is twice as high as that of the cement stone. At that, use of annually growing volume of flotation tailings in the production of the composite binder is a rational way for recycling this type of waste and allows saving the planet's natural resources.

The effects of two thick film deposition methods on tin dioxide gas sensor performance.

PubMed

Bakrania, Smitesh D; Wooldridge, Margaret S

2009-01-01

This work demonstrates the variability in performance between SnO(2) thick film gas sensors prepared using two types of film deposition methods. SnO(2) powders were deposited on sensor platforms with and without the use of binders. Three commonly utilized binder recipes were investigated, and a new binder-less deposition procedure was developed and characterized. The binder recipes yielded sensors with poor film uniformity and poor structural integrity, compared to the binder-less deposition method. Sensor performance at a fixed operating temperature of 330 °C for the different film deposition methods was evaluated by exposure to 500 ppm of the target gas carbon monoxide. A consequence of the poor film structure, large variability and poor signal properties were observed with the sensors fabricated using binders. Specifically, the sensors created using the binder recipes yielded sensor responses that varied widely (e.g., S = 5 - 20), often with hysteresis in the sensor signal. Repeatable and high quality performance was observed for the sensors prepared using the binder-less dispersion-drop method with good sensor response upon exposure to 500 ppm CO (S = 4.0) at an operating temperature of 330 °C, low standard deviation to the sensor response (±0.35) and no signal hysteresis.

The Effects of Two Thick Film Deposition Methods on Tin Dioxide Gas Sensor Performance

PubMed Central

Bakrania, Smitesh D.; Wooldridge, Margaret S.

2009-01-01

This work demonstrates the variability in performance between SnO2 thick film gas sensors prepared using two types of film deposition methods. SnO2 powders were deposited on sensor platforms with and without the use of binders. Three commonly utilized binder recipes were investigated, and a new binder-less deposition procedure was developed and characterized. The binder recipes yielded sensors with poor film uniformity and poor structural integrity, compared to the binder-less deposition method. Sensor performance at a fixed operating temperature of 330 °C for the different film deposition methods was evaluated by exposure to 500 ppm of the target gas carbon monoxide. A consequence of the poor film structure, large variability and poor signal properties were observed with the sensors fabricated using binders. Specifically, the sensors created using the binder recipes yielded sensor responses that varied widely (e.g., S = 5 – 20), often with hysteresis in the sensor signal. Repeatable and high quality performance was observed for the sensors prepared using the binder-less dispersion-drop method with good sensor response upon exposure to 500 ppm CO (S = 4.0) at an operating temperature of 330 °C, low standard deviation to the sensor response (±0.35) and no signal hysteresis. PMID:22399977

Preparation of Fiber Based Binder Materials to Enhance the Gas Adsorption Efficiency of Carbon Air Filter.

PubMed

Lim, Tae Hwan; Choi, Jeong Rak; Lim, Dae Young; Lee, So Hee; Yeo, Sang Young

2015-10-01

Fiber binder adapted carbon air filter is prepared to increase gas adsorption efficiency and environmental stability. The filter prevents harmful gases, as well as particle dusts in the air from entering the body when a human inhales. The basic structure of carbon air filter is composed of spunbond/meltblown/activated carbon/bottom substrate. Activated carbons and meltblown layer are adapted to increase gas adsorption and dust filtration efficiency, respectively. Liquid type adhesive is used in the conventional carbon air filter as a binder material between activated carbons and other layers. However, it is thought that the liquid binder is not an ideal material with respect to its bonding strength and liquid flow behavior that reduce gas adsorption efficiency. To overcome these disadvantages, fiber type binder is introduced in our study. It is confirmed that fiber type binder adapted air filter media show higher strip strength, and their gas adsorption efficiencies are measured over 42% during 60 sec. These values are higher than those of conventional filter. Although the differential pressure of fiber binder adapted air filter is relatively high compared to the conventional one, short fibers have a good potential as a binder materials of activated carbon based air filter.

Chelating effect in short polymers for the design of bidentate binders of increased affinity and selectivity

PubMed Central

Fortuna, Sara; Fogolari, Federico; Scoles, Giacinto

2015-01-01

The design of new strong and selective binders is a key step towards the development of new sensing devices and effective drugs. Both affinity and selectivity can be increased through chelation and here we theoretically explore the possibility of coupling two binders through a flexible linker. We prove the enhanced ability of double binders of keeping their target with a simple model where a polymer composed by hard spheres interacts with a spherical macromolecule, such as a protein, through two sticky spots. By Monte Carlo simulations and thermodynamic integration we show the chelating effect to hold for coupling polymers whose radius of gyration is comparable to size of the chelated particle. We show the binding free energy of flexible double binders to be higher than that of two single binders and to be maximized when the binding sites are at distances comparable to the mean free polymer end-to-end distance. The affinity of two coupled binders is therefore predicted to increase non linearly and in turn, by targeting two non-equivalent binding sites, this will lead to higher selectivity. PMID:26496975

Extending the Service Life of Pavements

NASA Astrophysics Data System (ADS)

Gschwendt, Ivan

2018-03-01

The cost of road construction and expenditures on the maintenance of pavements, i.e., their whole life cost, represents a lot of money. The paper describes a procedure for a pavement management system with degradation models and estimates the length of time for the rehabilitation of an asphalt pavement. Using a theory of pavement mechanics, we calculated the stresses and strains on the layers of two pavement models. High modulus asphalt concrete, an asphalt mix with a high binder content, and an asphalt mix with binder modifications are new road building materials. Prolonging the time for the rehabilitation of pavements is possible.

Viton's Impact on NASA Standard Initiator Propellant Properties

NASA Technical Reports Server (NTRS)

Hohmann, Carl; Tipton, Bill, Jr.

2000-01-01

This paper discusses some of the properties of Viton that are relevant to its use as a pyrotechnic binder in a NASA standard initiator (NSI) propellant. Nearly every aspect of NSI propellant manufacture and use is impacted by the binder system. The effect of Viton's molecular weight on solubility, solution viscosity, glass transition temperature, and strength characteristics as applied to NSI production and performance are reviewed. Emphasis is placed on the Viton fractionation that occurs during the precipitation cycle and its impact on bridgewire functions. Special consideration is given to the production of bridgewire slurry mixtures.

Privileged scaffolds or promiscuous binders: a glance of pyrrolo[2,1-f][1,2,4]triazines and related bridgehead nitrogen heterocycles in medicinal chemistry.

PubMed

Song, Yu'ning; Zhan, Peng; Zhang, Qingzhu; Liu, Xinyong

2013-01-01

Pyrrolo[2,1-f][1,2,4]triazine template, a unique bridgehead nitrogen heterocycle, certainly deserves the title of "privileged scaffold" in the drug discovery field because of the versatility and potential to yield derivatives with a wide range of biological activities, such as anti-anaplastic lymphoma kinase (ALK), Janus kinase 2 (JAK2), VEGFR-2, EGFR and/or HER2, Met kinase, p38α mitogen-activated protein (MAP) kinase and insulin-like growth factor receptor (IGF-1R) kinase activities, etc. These different biological properties of pyrrolo[2,1-f][1,2,4]triazine derivatives have motivated new studies in searching for novel derivatives with improved activity and also other applications in pharmaceutical field. However, no systematic review is available in the literature on the pyrrolo[2,1- f][1,2,4]triazine derivatives concerning the design of potent drug-like compounds. Owing to the importance of this heterocyclic system, the present paper is an attempt to the pharmacological activities, structural modifications and the structure-activity relationship (SAR) reported for bridgehead nitrogen heterocycles in the current literature, making an effort to highlight the importance and therapeutic potentials of the pyrrolo[2,1-f][1,2,4]triazine scaffold and its bridgehead nitrogen bioisosters as heterocyclic privileged medicinal scaffolds.

Modeling of Human Prokineticin Receptors: Interactions with Novel Small-Molecule Binders and Potential Off-Target Drugs

PubMed Central

Levit, Anat; Yarnitzky, Talia; Wiener, Ayana; Meidan, Rina; Niv, Masha Y.

2011-01-01

Background and Motivation The Prokineticin receptor (PKR) 1 and 2 subtypes are novel members of family A GPCRs, which exhibit an unusually high degree of sequence similarity. Prokineticins (PKs), their cognate ligands, are small secreted proteins of ∼80 amino acids; however, non-peptidic low-molecular weight antagonists have also been identified. PKs and their receptors play important roles under various physiological conditions such as maintaining circadian rhythm and pain perception, as well as regulating angiogenesis and modulating immunity. Identifying binding sites for known antagonists and for additional potential binders will facilitate studying and regulating these novel receptors. Blocking PKRs may serve as a therapeutic tool for various diseases, including acute pain, inflammation and cancer. Methods and Results Ligand-based pharmacophore models were derived from known antagonists, and virtual screening performed on the DrugBank dataset identified potential human PKR (hPKR) ligands with novel scaffolds. Interestingly, these included several HIV protease inhibitors for which endothelial cell dysfunction is a documented side effect. Our results suggest that the side effects might be due to inhibition of the PKR signaling pathway. Docking of known binders to a 3D homology model of hPKR1 is in agreement with the well-established canonical TM-bundle binding site of family A GPCRs. Furthermore, the docking results highlight residues that may form specific contacts with the ligands. These contacts provide structural explanation for the importance of several chemical features that were obtained from the structure-activity analysis of known binders. With the exception of a single loop residue that might be perused in the future for obtaining subtype-specific regulation, the results suggest an identical TM-bundle binding site for hPKR1 and hPKR2. In addition, analysis of the intracellular regions highlights variable regions that may provide subtype specificity. PMID:22132188

76 FR 81487 - Agency Information Collection Extension; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... to Kathleen Binder at kathleen.binder@hq.doe.gov . Correction In the Federal Register of December 16... corrected to read: (1) OMB No. 1910-5118; Issued in Washington, DC on December 21, 2011. Kathleen M. Binder...

Method of waste stabilization via chemically bonded phosphate ceramics

DOEpatents

Wagh, Arun S.; Singh, Dileep; Jeong, Seung-Young

1998-01-01

A method for regulating the reaction temperature of a ceramic formulation process is provided comprising supplying a solution containing a monovalent alkali metal; mixing said solution with an oxide powder to create a binder; contacting said binder with bulk material to form a slurry; and allowing the slurry to cure. A highly crystalline waste form is also provided consisting of a binder containing potassium and waste substrate encapsulated by the binder.

Method of waste stabilization via chemically bonded phosphate ceramics

DOEpatents

Wagh, A.S.; Singh, D.; Jeong, S.Y.

1998-11-03

A method for regulating the reaction temperature of a ceramic formulation process is provided comprising supplying a solution containing a monovalent alkali metal; mixing said solution with an oxide powder to create a binder; contacting said binder with bulk material to form a slurry; and allowing the slurry to cure. A highly crystalline waste form is also provided consisting of a binder containing potassium and waste substrate encapsulated by the binder. 3 figs.

Study of chloride ion transport of composite by using cement and starch as a binder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Armynah, Bidayatul; Halide, Halmar; Zahrawani,

This study presents the chemical bonding and the structural properties of composites from accelerator chloride test migration (ACTM). The volume fractions between binder (cement and starch) and charcoal in composites are 20:80 and 60:40. The effect of the binder to the chemical composition, chemical bonding, and structural properties before and after chloride ion passing through the composites was determined by X-ray fluorescence (XRF), by Fourier transform infra-red (FTIR), and x-ray diffraction (XRD), respectively. From the XRD data, XRF data, and the FTIR data shows the amount of chemical composition, the type of binding, and the structure of composites are dependingmore » on the type of binder. The amount of chloride migration using starch as binder is higher than that of cement as a binder due to the density effects.« less

In Vitro Adsorption and in Vivo Pharmacokinetic Interaction between Doxycycline and Frequently Used Mycotoxin Binders in Broiler Chickens.

PubMed

De Mil, Thomas; Devreese, Mathias; Broekaert, Nathan; Fraeyman, Sophie; De Backer, Patrick; Croubels, Siska

2015-05-06

Mycotoxin binders are readily mixed in feeds to prevent uptake of mycotoxins by the animal. Concerns were raised for nonspecific binding with orally administered veterinary drugs by the European Food Safety Authority in 2010. This paper describes the screening for in vitro adsorption of doxycycline-a broad-spectrum tetracycline antibiotic-to six different binders that were able to bind >75% of the doxycycline. Next, an in vivo pharmacokinetic interaction study of doxycycline with two of the binders, which demonstrated significant in vitro binding, was performed in broiler chickens using an oral bolus model. It was shown that two montmorillonite-based binders were able to lower the area under the plasma concentration-time curve of doxycycline by >60% compared to the control group. These results may indicate a possible risk for reduced efficacy of doxycycline when used concomitantly with montmorillonite-based mycotoxin binders.

Binder-induced surface structure evolution effects on Li-ion battery performance

NASA Astrophysics Data System (ADS)

Rezvani, S. J.; Pasqualini, M.; Witkowska, A.; Gunnella, R.; Birrozzi, A.; Minicucci, M.; Rajantie, H.; Copley, M.; Nobili, F.; Di Cicco, A.

2018-03-01

A comparative investigation on binder induced chemical and morphological evolution of Li4Ti5O12 electrodes was performed via X-ray photoemission spectroscopy, scanning electron microscopy, and electrochemical measurements. Composite electrodes were obtained using three different binders (PAA, PVdF, and CMC) with 80:10:10 ratio of active material:carbon:binder. The electrochemical performances of the electrodes, were found to be intimately correlated with the evolution of the microstructure of the electrodes, probed by XPS and SEM analysis. Our analysis shows that the surface chemistry, thickness of the passivation layers and the morphology of the electrodes are strongly dependent on the type of binders that significantly influence the electrochemical properties of the electrodes. These results point to a key role played by binders in optimization of the battery performance and improve our understanding of the previously observed and unexplained electrochemical properties of these electrodes.

Application of biomass-derived flexible carbon cloth coated with MnO2 nanosheets in supercapacitors

NASA Astrophysics Data System (ADS)

He, Shuijian; Chen, Wei

2015-10-01

Successful application of inexpensive energy storage devices lies in the exploitation of fabrication approaches that are based on cost-efficient materials and that can be easily scaled up. Here, inexpensive textile weaved by natural flax fiber is selected as raw material in preparing flexible and binder-free electrode material for supercapacitors. Although carbon fiber cloth obtained from the direct carbonization of flax textile exhibits a low specific capacitance of 0.78 F g-1, carbon fiber cloth electrode shows a very short relaxation time of 39.1 m s and good stability with almost 100% capacitance retaining after 104 cycles at 5 A g-1. To extend the application of the resulting carbon cloth in supercapacitor field, a layer of MnO2 nanosheets is deposited on the surface of carbon fiber via in situ redox reaction between carbon and KMnO4. The specific capacitance of MnO2 reaches 683.73 F g-1 at 2 A g-1 and still retains 269.04 F g-1 at 300 A g-1, indicating the excellent rate capacitance performance of the carbon cloth/MnO2 hybrids. The present study shows that carbon cloth derived from flax textile can provide a low-cost material platform for the facile, cost-efficient and large scale fabrication of binder-free electrode materials for energy storage devices.

Raman scattering or fluorescence emission? Raman spectroscopy study on lime-based building and conservation materials.

PubMed

Kaszowska, Zofia; Malek, Kamilla; Staniszewska-Slezak, Emilia; Niedzielska, Karina

2016-12-05

This work presents an in-depth study on Raman spectra excited with 1064 and 532nm lasers of lime binders employed in the past as building materials and revealed today as valuable conservation materials. We focus our interest on the bands of strong intensity, which are present in the spectra of all binders acquired with laser excitation at 1064nm, but absent in the corresponding spectra acquired with laser excitation at 532nm. We suggest, that the first group of spectra represents fluorescence phenomena of unknown origin and the second true Raman scattering. In our studies, we also include two other phases of lime cycle, i.e. calcium carbonate (a few samples of calcite of various origins) and calcium oxide (quicklime) to assess how structural and chemical transformations of lime phases affect the NIR-Raman spectral profile. Furthermore, we analyse a set of carbonated limewashes and lime binders derived from old plasters to give an insight into their spectral characteristics after excitation with the 1064nm laser line. NIR-Raman micro-mapping results are also presented to reveal the spatial distribution of building materials and fluorescent species in the cross-section of plaster samples taken from a 15th century chapel. Our study shows that the Raman analysis can help identify lime-based building and conservation materials, however, a caution is advised in the interpretation of the spectra acquired using 1064nm excitation. Copyright © 2016. Published by Elsevier B.V.

Investigation of newly discovered lobate scarps: Implications for the tectonic and thermal evolution of the Moon

NASA Astrophysics Data System (ADS)

Clark, Jaclyn D.; Hurtado, José M.; Hiesinger, Harald; van der Bogert, Carolyn H.; Bernhardt, Hannes

2017-12-01

Using observations of lunar scarps in Apollo Panoramic Camera photos, Binder and Gunga (1985) tested competing models for the initial thermal state of the Moon, i.e., whether it was initially completely molten or if the molten portion was limited to a global magma ocean. Binder and Gunga (1985) favored the concept of an initially molten Moon that had entered into a late-stage epoch of global tectonism. Since the start of the Lunar Reconnaissance Orbiter mission, thousands of new small lobate scarps have been identified across the lunar surface with high-resolution images from the Lunar Reconnaissance Orbiter Camera (LROC). As such, we selected spatially random scarps and reevaluated the fault dynamical calculations presented by Binder and Gunga (1985). Additionally, we examined the geometry and properties of these fault scarps and place better constraints on the amount of scarp-related crustal shortening. We found that these low angle thrust faults (∼23˚) have an average relief of ∼40 m and average depths of 951 m. Using crater size-frequency distribution (CSFD) measurements, we derived absolute model ages for the scarp surfaces proximal to the trace of the fault and found that the last slip event occurred in the last ∼132 Ma. Along with young model ages, lunar lobate scarps exhibit a youthful appearance with their crisp morphologies which is indicative of late-stage horizontal shortening. In conclusion, interior secular cooling and tidal stresses cause global contraction of the Moon.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Nacre, also known as mother-of-pearl, is a biocomposite material that exhibits higher strength and fracture toughness than its component materials. It derives its strength from the brick-and-mortar layering of aragonite (CaCO{sub 3}) platelets and organic binder. It is believed that the protein binder helps redistribute the stress throughout all tablets for optimal mechanical performance. In this study, we attempt to measure the mechanical properties of aragonite within nacre and compare them to bulk aragonite and bulk nacre and understand the redistribution of stresses. Here we show that x-ray diffraction techniques are useful for isolating and measuring strain of crystallites withinmore » a composite material. Our results show that the apparent stiffness of aragonite varies with crystallographic directions and is higher than the stiffness of bulk nacre in all cases, meaning that aragonite tablets are exposed to less than the average bulk stress. The average force applied to the bulk sample is partitioned between the aragonite and the binder, so that the protein layer bears as much as 27.2% of the total applied force. Different crystallographic directions exhibit behaviors different than bulk aragonite or bulk nacre. These are related to texture of aragonite platelets (i.e. preferred orientations within nacre). By examining nacre, we can obtain a better understanding of the mechanical relationship between the ceramic and polymer in composite materials. We expect that x-ray diffraction will become the standard method for probing the mechanical properties of composite materials.« less

Development of an Image-based Multi-Scale Finite Element Approach to Predict Fatigue Damage in Asphalt Mixtures

NASA Astrophysics Data System (ADS)

Arshadi, Amir

Image-based simulation of complex materials is a very important tool for understanding their mechanical behavior and an effective tool for successful design of composite materials. In this thesis an image-based multi-scale finite element approach is developed to predict the mechanical properties of asphalt mixtures. In this approach the "up-scaling" and homogenization of each scale to the next is critically designed to improve accuracy. In addition to this multi-scale efficiency, this study introduces an approach for consideration of particle contacts at each of the scales in which mineral particles exist. One of the most important pavement distresses which seriously affects the pavement performance is fatigue cracking. As this cracking generally takes place in the binder phase of the asphalt mixture, the binder fatigue behavior is assumed to be one of the main factors influencing the overall pavement fatigue performance. It is also known that aggregate gradation, mixture volumetric properties, and filler type and concentration can affect damage initiation and progression in the asphalt mixtures. This study was conducted to develop a tool to characterize the damage properties of the asphalt mixtures at all scales. In the present study the Viscoelastic continuum damage model is implemented into the well-known finite element software ABAQUS via the user material subroutine (UMAT) in order to simulate the state of damage in the binder phase under the repeated uniaxial sinusoidal loading. The inputs are based on the experimentally derived measurements for the binder properties. For the scales of mastic and mortar, the artificially 2-Dimensional images of mastic and mortar scales were generated and used to characterize the properties of those scales. Finally, the 2D scanned images of asphalt mixtures are used to study the asphalt mixture fatigue behavior under loading. In order to validate the proposed model, the experimental test results and the simulation results were compared. Indirect tensile fatigue tests were conducted on asphalt mixture samples. A comparison between experimental results and the results from simulation shows that the model developed in this study is capable of predicting the effect of asphalt binder properties and aggregate micro-structure on mechanical behavior of asphalt concrete under loading.

Time dependent viscoelastic rheological response of pure, modified and synthetic bituminous binders

NASA Astrophysics Data System (ADS)

Airey, G. D.; Grenfell, J. R. A.; Apeagyei, A.; Subhy, A.; Lo Presti, D.

2016-08-01

Bitumen is a viscoelastic material that exhibits both elastic and viscous components of response and displays both a temperature and time dependent relationship between applied stresses and resultant strains. In addition, as bitumen is responsible for the viscoelastic behaviour of all bituminous materials, it plays a dominant role in defining many of the aspects of asphalt road performance, such as strength and stiffness, permanent deformation and cracking. Although conventional bituminous materials perform satisfactorily in most highway pavement applications, there are situations that require the modification of the binder to enhance the properties of existing asphalt material. The best known form of modification is by means of polymer modification, traditionally used to improve the temperature and time susceptibility of bitumen. Tyre rubber modification is another form using recycled crumb tyre rubber to alter the properties of conventional bitumen. In addition, alternative binders (synthetic polymeric binders as well as renewable, environmental-friendly bio-binders) have entered the bitumen market over the last few years due to concerns over the continued availability of bitumen from current crudes and refinery processes. This paper provides a detailed rheological assessment, under both temperature and time regimes, of a range of conventional, modified and alternative binders in terms of the materials dynamic (oscillatory) viscoelastic response. The rheological results show the improved viscoelastic properties of polymer- and rubber-modified binders in terms of increased complex shear modulus and elastic response, particularly at high temperatures and low frequencies. The synthetic binders were found to demonstrate complex rheological behaviour relative to that seen for conventional bituminous binders.

Grafting of functional motifs onto protein scaffolds identified by PDB screening--an efficient route to design optimizable protein binders.

PubMed

Tlatli, Rym; Nozach, Hervé; Collet, Guillaume; Beau, Fabrice; Vera, Laura; Stura, Enrico; Dive, Vincent; Cuniasse, Philippe

2013-01-01

Artificial miniproteins that are able to target catalytic sites of matrix metalloproteinases (MMPs) were designed using a functional motif-grafting approach. The motif corresponded to the four N-terminal residues of TIMP-2, a broad-spectrum protein inhibitor of MMPs. Scaffolds that are able to reproduce the functional topology of this motif were obtained by exhaustive screening of the Protein Data Bank (PDB) using STAMPS software (search for three-dimensional atom motifs in protein structures). Ten artificial protein binders were produced. The designed proteins bind catalytic sites of MMPs with affinities ranging from 450 nm to 450 μm prior to optimization. The crystal structure of one artificial binder in complex with the catalytic domain of MMP-12 showed that the inter-molecular interactions established by the functional motif in the artificial binder corresponded to those found in the MMP-14-TIMP-2 complex, albeit with some differences in geometry. Molecular dynamics simulations of the ten binders in complex with MMP-14 suggested that these scaffolds may allow partial reproduction of native inter-molecular interactions, but differences in geometry and stability may contribute to the lower affinity of the artificial protein binders compared to the natural protein binder. Nevertheless, these results show that the in silico design method used provides sets of protein binders that target a specific binding site with a good rate of success. This approach may constitute the first step of an efficient hybrid computational/experimental approach to protein binder design. © 2012 The Authors Journal compilation © 2012 FEBS.

Initiator system in holographic photopolymer materials

NASA Astrophysics Data System (ADS)

Ortuño, M.; Fernández, E.; Fuentes, R.; Gallego, S.; Márquez, A.

2010-05-01

The photopolymers with a hydrophilic matrix as poly(vinyl alcohol), PVA, are versatile holographic recording materials in hologram recording experiments. They use water as solvent and they can be made in layers with several thickness. One of the photopolymers more used is composed of acrylamide as polymerizable monomer, PVA and water as binder. The pair: triethanolamine, TEA, and the dye yellowish eosin, YE, is widely used as initiator system due to its high sensitivity and efficiency. TEA is the radical initiator more used with dyes derived from fluorescein as YE because they can generate a radical by redox reaction under dye excitation by light. The dye is bleached in this process because is decomposed in the photoinitiation reaction. The ethylenediaminetetraacetic acid EDTA has a molecular structure very similar to TEA and therefore could replace it in this kind of photopolymers. The 4,4' azo-bis-(4-cyanopentanoic acid), ACPA, is a radical initiator that is soluble in water and usually used in polymerizations in solution with thermal initiation. In this work, we use EDTA and ACPA in order to check their properties as radical initiator in the photochemical reaction that takes place inside the photopolymer while a hologram is being recorded. We will compare the results obtained with those derived from TEA and will evaluate the possibilities for these substances.

MATCON MODIFIED ASPHALT COVER CONTAINMENT SYSTEM DEMONSTRATION

EPA Science Inventory

In order to make improvements to conventional paving asphalt to make it more suitable for containment applications, Wilder Construction Co. of Everett, WA offers MatCon, a polymer modified asphalt system comprised of proprietary binder, when coupled with a selected aggregate type...

The evaluation and specification development of alternate modified asphalt binders in South Carolina : final report.

DOT National Transportation Integrated Search

2014-11-01

In this research project, asphalt binders containing various polymer modifiers were investigated through : examining both binder and mixture properties.Two additional topics were also investigated, including: a) the : effects of liquid antistr...

78 FR 73503 - Procurement List Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

...: 7510-01-462-1383--Binder, Loose-leaf, View Framed, Navy Blue, 1/2''. NSN: 7510-01-462-1385--Binder, Loose-leaf, Frame View, Navy Blue, 1-1/2''. NSN: 7510-01-462-1386--Binder, Loose-leaf, View Framed...

Laboratory evaluation of asphalt binder rutting, fracture, and adhesion tests.

DOT National Transportation Integrated Search

2014-04-01

The current performance grading (PG) specification for asphalt binders was developed based on the Strategic Highway : Research Program (SHRP) and is based primarily on the study of unmodified asphalt binders. Over the years, experience has : proven t...

Quantification and modeling of mechanical degradation in lithium-ion batteries based on nanoscale imaging.

PubMed

Müller, Simon; Pietsch, Patrick; Brandt, Ben-Elias; Baade, Paul; De Andrade, Vincent; De Carlo, Francesco; Wood, Vanessa

2018-06-14

Capacity fade in lithium-ion battery electrodes can result from a degradation mechanism in which the carbon black-binder network detaches from the active material. Here we present two approaches to visualize and quantify this detachment and use the experimental results to develop and validate a model that considers how the active particle size, the viscoelastic parameters of the composite electrode, the adhesion between the active particle and the carbon black-binder domain, and the solid electrolyte interphase growth rate impact detachment and capacity fade. Using carbon-silicon composite electrodes as a model system, we demonstrate X-ray nano-tomography and backscatter scanning electron microscopy with sufficient resolution and contrast to segment the pore space, active particles, and carbon black-binder domain and quantify delamination as a function of cycle number. The validated model is further used to discuss how detachment and capacity fade in high-capacity materials can be minimized through materials engineering.

Conductive Polymer Binder-Enabled SiO–Sn xCo yC z Anode for High-Energy Lithium-Ion Batteries

DOE PAGES

Zhao, Hui; Fu, Yanbao; Ling, Min; ...

2016-05-10

In this paper, a SiOSnCoC composite anode is assembled using a conductive polymer binder for the application in next-generation high energy density lithium-ion batteries. A specific capacity of 700 mAh/g is achieved at a 1C (900 mA/g) rate. A high active material loading anode with an areal capacity of 3.5 mAh/cm 2 is demonstrated by mixing SiOSnCoC with graphite. To compensate for the lithium loss in the first cycle, stabilized lithium metal powder (SLMP) is used for prelithiation; when paired with a commercial cathode, a stable full cell cycling performance with a 86% first cycle efficiency is realized. Finally, bymore » achieving these important metrics toward a practical application, this conductive polymer binder/SiOSnCoC anode system presents great promise to enable the next generation of high-energy lithium-ion batteries.« less

Investigating the Doping Mechanism of Pyrene Based Methacrylate Functional Conductive Binder in Silicon Anodes for Lithium-Ion Batteries

DOE PAGES

Ling, Min; Liu, Michael; Zheng, Tianyue; ...

2017-01-01

The doping mechanism of poly (1-pyrenemethyl methacrylate) (PPy) is investigated through electrochemical analytical and spectroscopic method. The performance of PPy as a Si materials binder is studied and compared with that of a commercial available lithium polyacrylate (PAALi) binder. The pyrene moiety consumes lithium ions according to the cyclic voltammogram (CV) measurement, as a doping to the PPy binder. Based on the lithium consumption, PPy based Si/graphite electrode doping is quantified at 1.1 electron/pyrene moiety. Lastly, the PPy binder based electrodes surface are uniform and crack free during lithiation/delithiation, which is revealed through Scanning electron microscope (SEM) imaging.

Development of bio-sourced binder to metal injection moulding

NASA Astrophysics Data System (ADS)

Royer, Alexandre; Barrière, Thierry; Gelin, Jean-Claude

2016-10-01

In the MIM process the binder play the most important role. It provides fluidity of the feedstock mixture for injection molding and adhesion of the powder to keep the molded shape. The binder must provide strength and cohesion for the molded part, must be easy to be removed from the molded part, and must be the recyclable, environmentally friendly and economical ones. The goal of this study is to develop a binder environmentally friendly. For this, a study of formulation based on polyethylene glycol, because of is water debinding properties, was made. Polylactic acid and Polyhydroxyalkanoates were investigated as bio sourced polymers. The chemical, miscibility and rheological behavior of the binder formulation were investigated.

Phosphate binders for the treatment of hyperphosphatemia in chronic kidney disease patients on dialysis: a comparison of safety profiles.

PubMed

Locatelli, Francesco; Del Vecchio, Lucia; Violo, Leano; Pontoriero, Giuseppe

2014-05-01

Hyperphosphatemia is common in the late stages of chronic kidney disease (CKD) and is associated with elevated parathormone levels, abnormal bone mineralization, extraosseous calcification and increased risk of cardiovascular events and death. Several classes of oral phosphate binders are available to help control phosphorus levels. Although effective at lowering serum phosphorus, they all have safety issues that need to be considered when selecting which one to use. This paper reviews the use of phosphate binders in patients with CKD on dialysis, with a focus on safety and tolerability. In addition to the more established agents, a new resin-based phosphate binder, colestilan, is discussed. Optimal phosphate control is still an unmet need in CKD. Nonetheless, we now have an extending range of phosphate binders available. Aluminium has potentially serious toxic risks. Calcium-based binders are still very useful but can lead to hypercalcemia and/or positive calcium balance and cardiovascular calcification. No long-term data are available for the new calcium acetate/magnesium combination product. Lanthanum is an effective phosphate binder, but there is insufficient evidence about possible long-term effects of tissue deposition. The resin-based binders, colestilan and sevelamer, appear to have profiles that would lead to less vascular calcification, and the main adverse events seen with these agents are gastrointestinal effects.

Reuse potential of low-calcium bottom ash as aggregate through pelletization.

PubMed

Geetha, S; Ramamurthy, K

2010-01-01

Coal combustion residues which include fly ash, bottom ash and boiler slag is one of the major pollutants as these residues require large land area for their disposal. Among these residues, utilization of bottom ash in the construction industry is very low. This paper explains the use of bottom ash through pelletization. Raw bottom ash could not be pelletized as such due to its coarseness. Though pulverized bottom ash could be pelletized, the pelletization efficiency was low, and the aggregates were too weak to withstand the handling stresses. To improve the pelletization efficiency, different clay and cementitious binders were used with bottom ash. The influence of different factors and their interaction effects were studied on the duration of pelletization process and the pelletization efficiency through fractional factorial design. Addition of binders facilitated conversion of low-calcium bottom ash into aggregates. To achieve maximum pelletization efficiency, the binder content and moisture requirements vary with type of binder. Addition of Ca(OH)(2) improved the (i) pelletization efficiency, (ii) reduced the duration of pelletization process from an average of 14-7 min, and (iii) reduced the binder dosage for a given pelletization efficiency. For aggregate with clay binders and cementitious binder, Ca(OH)(2) and binder dosage have significant effect in reducing the duration of pelletization process. 2010 Elsevier Ltd. All rights reserved.

Effects of compatibility of polymer binders with solvate ionic liquid electrolytes on discharge and charge reactions of lithium-sulfur batteries

NASA Astrophysics Data System (ADS)

Nakazawa, Toshitada; Ikoma, Ai; Kido, Ryosuke; Ueno, Kazuhide; Dokko, Kaoru; Watanabe, Masayoshi

2016-03-01

Electrochemical reactions in Li-S cells with a solvate ionic liquid (SIL) electrolyte composed of tetraglyme (G4) and Li[TFSA] (TFSA: bis(trifluoromethanesulfonyl)amide) are studied. The sulfur cathode (S cathode) comprises sulfur, carbon powder, and a polymer binder. Poly(ethylene oxide) (PEO) and poly(vinyl alcohol) (PVA-x) with different degrees of saponification (x%) are used as binders to prepare the composite cathodes. For the Li-S cell containing PEO binder, lithium polysulfides (Li2Sm, 2 ≤ m ≤ 8), reaction intermediates of the S cathode, dissolve into the electrolyte, and Li2Sm acts as a redox shuttle in the Li-S cell. In contrast, in the Li-S cell with PVA-x binder, the dissolution of Li2Sm is suppressed, leading to high columbic efficiencies during charge-discharge cycles. The compatibility of the PVA-x binder with the SIL electrolyte changes depending on the degree of saponification. Decreasing the degree of saponification leads to increased electrolyte uptake by the PVA-x binder, increasing the charge and discharge capacities of Li-S cell. The rate capability of Li-S cell is also enhanced by the partial swelling of the PVA-x binder. The enhanced performance of Li-S cell containing PVA-x is attributed to the lowering of resistance of Li+ ion transport in the composite cathode.

Mechanical and Permeability Characteristics of Latex-Modified Pre-Packed Pavement Repair Concrete as a Function of the Rapid-Set Binder Content

PubMed Central

Han, Jae-Woong; Jeon, Ji-Hong; Park, Chan-Gi

2015-01-01

We evaluated the strength and durability characteristics of latex-polymer-modified, pre-packed pavement repair concrete (LMPPRC) with a rapid-set binder. The rapid-set binder was a mixture of rapid-set cement and silica sand, where the fluidity was controlled using a latex polymer. The resulting mix exhibited a compressive strength of ≥21 MPa and a flexural strength of ≥3.5 MPa after 4 h of curing (i.e., the traffic opening term for emergency repairs of pavement). The ratio of latex polymer to rapid-set binder material was varied through 0.40, 0.33, 0.29, and 0.25. Mechanical characterization revealed that the mechanical performance, permeability, and impact resistance increased as the ratio of latex polymer to rapid-set binder decreased. The mixture exhibited a compressive strength of ≥21 MPa after 4 h when the ratio of latex polymer to rapid-set binder material was ≤0.29. The mixture exhibited a flexural strength of ≥3.5 MPa after 4 h when the ratio of latex polymer to rapid-set binder material was ≤0.33. The permeability resistance to chloride ions satisfied 2000 C after 7 days of curing for all ratios. The ratio of latex polymer to rapid-set binder material that satisfied all conditions for emergency pavement repair was ≤0.29. PMID:28793596

Mechanical and Permeability Characteristics of Latex-Modified Pre-Packed Pavement Repair Concrete as a Function of the Rapid-Set Binder Content.

PubMed

Han, Jae-Woong; Jeon, Ji-Hong; Park, Chan-Gi

2015-10-01

We evaluated the strength and durability characteristics of latex-polymer-modified, pre-packed pavement repair concrete (LMPPRC) with a rapid-set binder. The rapid-set binder was a mixture of rapid-set cement and silica sand, where the fluidity was controlled using a latex polymer. The resulting mix exhibited a compressive strength of ¥21 MPa and a flexural strength of ¥3.5 MPa after 4 h of curing (i.e., the traffic opening term for emergency repairs of pavement). The ratio of latex polymer to rapid-set binder material was varied through 0.40, 0.33, 0.29, and 0.25. Mechanical characterization revealed that the mechanical performance, permeability, and impact resistance increased as the ratio of latex polymer to rapid-set binder decreased. The mixture exhibited a compressive strength of ¥21 MPa after 4 h when the ratio of latex polymer to rapid-set binder material was ¤0.29. The mixture exhibited a flexural strength of ¥3.5 MPa after 4 h when the ratio of latex polymer to rapid-set binder material was ¤0.33. The permeability resistance to chloride ions satisfied 2000 C after 7 days of curing for all ratios. The ratio of latex polymer to rapid-set binder material that satisfied all conditions for emergency pavement repair was ¤0.29.

Composite propellant combustion with low aluminum agglomeration

NASA Astrophysics Data System (ADS)

Mullen, Jessica Christine

Aluminum behavior---accumulation, agglomeration and ignition---is studied in a unique, wide-distribution, ammonium perchlorate/hydroxyl-terminated polybutadiene (AP/HTPB) propellant formulation that results in low Al agglomeration, even at low pressures (1--30 atm). Variations in formulation---such as fine-AP/binder ratio, Al particle size, Al loading, coarse-AP size---are also examined. A fuel-rich, oxygenated binder matrix highly loaded with fine (2-mum) AP (FAP) at 75/25:FAP/binder (by mass) is found to have premixed flame conditions that produce minimal agglomeration (without ignition) of 15-mum Al. Coarse AP (CAP) is added to the system in the form of either particles (200 or 400 mum) or pressed-AP laminates (simulated CAP). In the 2-D laminate system the CAP/oxyfuel-matrix flame structure is seen to be similar to that previously described for non-aluminized laminates with split (diffusion) and merged (partially-premixed) flame regimes, depending on pressure and fuel-matrix thickness. Both laminate and particulate systems show that with CAP present, Al can agglomerate more extensively on CAP via lateral surface migration from fuel matrix to the CAP region. The particulate CAP system also shows that Al can accumulate/agglomerate via settling on CAP from above (in the direction of burning). Both systems, but more clearly the 2-D laminates, show that with CAP present, Al is ignited by the outer CAP/fuel-matrix canopy flames. Thus, a propellant formulation is proposed for reducing overall Al agglomeration through intrinsically reduced agglomeration in the fuel-matrix and a reduced number of CAP-particle agglomerates via higher FAP/CAP ratio.

Installation and laboratory evaluation of alternatives to conventional polymer modification for asphalt.

DOT National Transportation Integrated Search

2015-01-01

The Virginia Department of Transportation (VDOT) specifies polymer-modified asphalt binders for certain asphalt : mixtures used on high-volume, high-priority routes. These binders must meet performance grade (PG) requirements for a PG : 76-22 binder ...

40 CFR 427.40 - Applicability; description of the asbestos paper (elastomeric binder) subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... asbestos paper (elastomeric binder) subcategory. 427.40 Section 427.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Elastomeric Binder) Subcategory § 427.40 Applicability...

40 CFR 427.40 - Applicability; description of the asbestos paper (elastomeric binder) subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... asbestos paper (elastomeric binder) subcategory. 427.40 Section 427.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Elastomeric Binder) Subcategory § 427.40 Applicability...

40 CFR 427.40 - Applicability; description of the asbestos paper (elastomeric binder) subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... asbestos paper (elastomeric binder) subcategory. 427.40 Section 427.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Elastomeric Binder) Subcategory § 427.40 Applicability...

Impact of Recycled Asphalt Shingles (RAS) on Asphalt Binder Performance

DOT National Transportation Integrated Search

2018-01-01

This study evaluated the effect of reclaimed asphalt pavement (RAP) and recycled asphalt shingles (RAS) on virgin binder true grade and fracture energy density (FED). A mortar approach, which avoids the need for binder extraction, was adopted to quan...

40 CFR 247.16 - Non-paper office products.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-paper office products. (a) Office recycling containers and office waste receptacles. (b) Plastic desktop accessories. (c) Toner cartridges. (d) Plastic-covered binders containing recovered plastic; chipboard and pressboard binders containing recovered paper; and solid plastic binders containing recovered plastic. (e...

Guidelines on design and construction of high performance thin HMA overlays.

DOT National Transportation Integrated Search

2016-08-01

Key Components of Mix Design and Material Properties: : High-quality aggregate - SAC A for high : volume roads : - PG 70 or 76 (Polymer Modified binders) : - RAP and RAS (shingles) not allowed : - Minimum binder content ( Over 6%) : - Pay for binder ...

40 CFR 247.16 - Non-paper office products.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-paper office products. (a) Office recycling containers and office waste receptacles. (b) Plastic desktop accessories. (c) Toner cartridges. (d) Plastic-covered binders containing recovered plastic; chipboard and pressboard binders containing recovered paper; and solid plastic binders containing recovered plastic. (e...

40 CFR 247.16 - Non-paper office products.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-paper office products. (a) Office recycling containers and office waste receptacles. (b) Plastic desktop accessories. (c) Toner cartridges. (d) Plastic-covered binders containing recovered plastic; chipboard and pressboard binders containing recovered paper; and solid plastic binders containing recovered plastic. (e...

40 CFR 247.16 - Non-paper office products.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-paper office products. (a) Office recycling containers and office waste receptacles. (b) Plastic desktop accessories. (c) Toner cartridges. (d) Plastic-covered binders containing recovered plastic; chipboard and pressboard binders containing recovered paper; and solid plastic binders containing recovered plastic. (e...

40 CFR 247.16 - Non-paper office products.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-paper office products. (a) Office recycling containers and office waste receptacles. (b) Plastic desktop accessories. (c) Toner cartridges. (d) Plastic-covered binders containing recovered plastic; chipboard and pressboard binders containing recovered paper; and solid plastic binders containing recovered plastic. (e...

Evaluation of new binders using newly developed fracture energy test.

DOT National Transportation Integrated Search

2013-07-01

This study evaluated a total of seven asphalt binders with various additives : using the newly developed binder fracture energy test. The researchers prepared and : tested PAV-aged and RTFO-plus-PAV-aged specimens. This study confirmed previous : res...

Defining the RNA Internal Loops Preferred by Benzimidazole Derivatives via Two-Dimensional Combinatorial Screening and Computational Analysis

PubMed Central

Velagapudi, Sai Pradeep; Seedhouse, Steven J.; French, Jonathan

2011-01-01

RNA is an important therapeutic target, however, RNA targets are generally underexploited due to a lack of understanding of the small molecules that bind RNA and the RNA motifs that bind small molecules. Herein, we describe the identification of the RNA internal loops derived from a 4096-member 3×3 nucleotide loop library that are the most specific and highest affinity binders to a series of four designer, drug-like benzimidazoles. These studies establish a potentially general protocol to define the highest affinity and most specific RNA motif targets for heterocyclic small molecules. Such information could be used to target functionally important RNAs in genomic sequence. PMID:21604752

Pressurized feeding on the GEGAS system

NASA Technical Reports Server (NTRS)

Furman, A. H.

1977-01-01

A continuous process to feed coal directly into a pressurized gasifier is described. Coal fines are heated and mixed with a recycled tar binder and extruded through a novel die system against gasifier pressure. Performance data on a 2 in. system is given and scale up to a larger 6 in. system is described.

Viscoelastic behaviour of cold recycled asphalt mixes

NASA Astrophysics Data System (ADS)

Cizkova, Zuzana; Suda, Jan

2017-09-01

Behaviour of cold recycled mixes depends strongly on both the bituminous binder content (bituminous emulsion or foamed bitumen) and the hydraulic binder content (usually cement). In the case of cold recycled mixes rich in bitumen and with low hydraulic binder content, behaviour is close to the viscoelastic behaviour of traditional hot mix asphalt. With decreasing bituminous binder content together with increasing hydraulic binder content, mixes are characteristic with brittle behaviour, typical for concrete pavements or hydraulically bound layers. The behaviour of cold recycled mixes with low content of both types of binders is similar to behaviour of unbound materials. This paper is dedicated to analysing of the viscoelastic behaviour of the cold recycled mixes. Therefore, the tested mixes contained higher amount of the bituminous binder (both foamed bitumen and bituminous emulsion). The best way to characterize any viscoelastic material in a wide range of temperatures and frequencies is through the master curves. This paper includes interesting findings concerning the dependency of both parts of the complex modulus (elastic and viscous) on the testing frequency (which simulates the speed of heavy traffic passing) and on the testing temperature (which simulates the changing climate conditions a real pavement is subjected to).

A "Sticky" Mucin-Inspired DNA-Polysaccharide Binder for Silicon and Silicon-Graphite Blended Anodes in Lithium-Ion Batteries.

PubMed

Kim, Sunjin; Jeong, You Kyeong; Wang, Younseon; Lee, Haeshin; Choi, Jang Wook

2018-05-14

New binder concepts have lately demonstrated improvements in the cycle life of high-capacity silicon anodes. Those binder designs adopt adhesive functional groups to enhance affinity with silicon particles and 3D network conformation to secure electrode integrity. However, homogeneous distribution of silicon particles in the presence of a substantial volumetric content of carbonaceous components (i.e., conductive agent, graphite, etc.) is still difficult to achieve while the binder maintains its desired 3D network. Inspired by mucin, the amphiphilic macromolecular lubricant, secreted on the hydrophobic surface of gastrointestine to interface aqueous serous fluid, here, a renatured DNA-alginate amphiphilic binder for silicon and silicon-graphite blended electrodes is reported. Mimicking mucin's structure comprised of a hydrophobic protein backbone and hydrophilic oligosaccharide branches, the renatured DNA-alginate binder offers amphiphilicity from both components, along with a 3D fractal network structure. The DNA-alginate binder facilitates homogeneous distribution of electrode components in the electrode as well as its enhanced adhesion onto a current collector, leading to improved cyclability in both silicon and silicon-graphite blended electrodes. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Coercivity Recovery Effect of Sm-Fe-Cu-Al Alloy on Sm2Fe17N3 Magnet

NASA Astrophysics Data System (ADS)

Otogawa, Kohei; Asahi, Toru; Jinno, Miho; Yamaguchi, Wataru; Takagi, Kenta; Kwon, Hansang

2018-03-01

The potential of a Sm-Fe-Cu-Al binder for improvement of the magnetic properties of Sm2Fe17N3 was examined. Transmission electron microscope (TEM) observation of a Sm-Fe-Cu-Al alloy-bonded Sm2Fe17N3 magnet which showed high coercivity revealed that the Sm-Fe-Cu-Al alloy had an effect of removing the surface oxide layer of the Sm2 Fe17N3 grains. However, the Sm-Fe-Cu-Al binder was contaminated by carbon and nitrogen, which originated from the organic solvent used as the milling medium during pulverization. To prevent carbon and nitrogen contamination, the Sm-Fe- Cu-Al alloy was added directly on the surface of the Sm2Fe17N3 grains by sputtering. Comparing the recovered coercivity per unit amount of the added binder the uncontaminated binder-coated sample had a higher coercivity recovery effect than the milled binder-added sample. These results suggested that sufficient addition of the contamination-free Sm-Fe-Cu-Al binder has the possibility to reduce the amount of binder necessary to produce a high coercive Sm2Fe17N3 magnet.

Analysis of the binder yield energy test as an indicator of fatigue behaviour of asphalt mixes

NASA Astrophysics Data System (ADS)

O'Connell, Johan; Mturi, Georges A. J.; Komba, Julius; Du Plessis, Louw

2017-09-01

Empirical binder testing has increasingly failed to predict pavement performance in South Africa, with fatigue cracking being one of the major forms of premature pavement distress. In response, it has become a national aspiration to incorporate a performance related fatigue test into the binder specifications for South Africa. The Binder Yield Energy Test (BYET) was the first in a series of tests analysed for its potential to predict the fatigue performance of the binder. The test is performed with the dynamic shear rheometer, giving two key parameters, namely, yield energy and shear strain at maximum shear stress (γτmax). The objective of the investigation was to perform a rudimentary evaluation of the BYET; followed by a more in-depth investigation should the initial BYET results prove promising. The paper discusses the results generated from the BYET under eight different conditions, using six different binders. The results are then correlated with four point bending beam fatigue test results obtained from asphalt mix samples that were manufactured from the same binders. Final results indicate that the BYET is not ideal as an indicator of fatigue performance.

Effects of ageing on different binders for retouching and on some binder-pigment combinations used for restoration of wall paintings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ropret, P.; Zoubek, R.; Skapin, A. Sever

2007-11-15

In restoration of colour layers, the selection of the most appropriate retouching binder is a very important step that may have a crucial impact on materials durability. As different weather conditions can have versatile influence on stability of colour layers, we determined the effect of ageing on carefully selected samples of binders (Tylose, Klucel, ammonium caseinate, gum arabicum, fish and skin glues and some other synthetic binders) as well as on several binder-pigment combinations (the pigments in combinations being cinnabar, green earth and smalt). The samples were subjected to accelerated ageing tests in climatic chambers. In these tests the temperaturemore » and the relative humidity were daily oscillating between - 20 deg. C and 50 deg. C and 50% to 90%, respectively, for a period of one month. Then the samples were exposed to UV and visible light generated by a metal halide lamp for a month. The differences in microstructure before and after ageing were determined by optical and scanning electron microscopy, while the ageing of the organic structures in binders was investigated by Fourier transform infrared (FTIR) microscopy.« less

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

PubMed

Klein, Tobias; Henn, Claudia; de Jong, Johannes C; Zimmer, Christina; Kirsch, Benjamin; Maurer, Christine K; Pistorius, Dominik; Müller, Rolf; Steinbach, Anke; Hartmann, Rolf W

2012-09-21

The Gram-negative pathogen Pseudomonas aeruginosa produces an intercellular alkyl quinolone signaling molecule, the Pseudomonas quinolone signal. The pqs quorum sensing communication system that is characteristic for P. aeruginosa regulates the production of virulence factors. Therefore, we consider the pqs system a novel target to limit P. aeruginosa pathogenicity. Here, we present small molecules targeting a key player of the pqs system, PqsR. A rational design strategy in combination with surface plasmon resonance biosensor analysis led to the identification of PqsR binders. Determination of thermodynamic binding signatures and functional characterization in E. coli guided the hit optimization, resulting in the potent hydroxamic acid derived PqsR antagonist 11 (IC(50) = 12.5 μM). Remarkably it displayed a comparable potency in P. aeruginosa (IC(50) = 23.6 μM) and reduced the production of the virulence factor pyocyanin. Beyond this, site-directed mutagenesis together with thermodynamic analysis provided insights into the energetic characteristics of protein-ligand interactions. Thus the identified PqsR antagonists are promising scaffolds for further drug design efforts against this important pathogen.

Validity of multiple stress creep recovery (MSCR) test for DOTD asphalt binder specification : final report 564.

DOT National Transportation Integrated Search

2017-09-01

Numerous studies have shown that G*/Sin, the high temperature specification parameter for current Performance Graded (PG) asphalt binder is not adequate to reflect the rutting characteristics of polymer-modified binders. Consequently, many state De...

Validity of multiple stress creep recovery (MSCR) test for DOTD asphalt binder specification : technical summary.

DOT National Transportation Integrated Search

2017-09-01

Higher traffic coupled with heavier loads led the asphalt industry to introduce polymer-modified binders to enhance the durability and strength of hot mix asphalt (HMA) pavements. When the Superpave Performance Graded (PG) binder specification (AASHT...

Self-healing composites and applications thereof

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tee, Chee Keong; Wang, Chao; Cui, Yi

A battery electrode includes an electrochemically active material and a binder covering the electrochemically active material. The binder includes a self-healing polymer and conductive additives dispersed in the self-healing polymer to provide an electrical pathway across at least a portion of the binder.

40 CFR 427.40 - Applicability; description of the asbestos paper (elastomeric binder) subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... asbestos paper (elastomeric binder) subcategory. 427.40 Section 427.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Elastomeric Binder) Subcategory § 427.40 Applicability; description of...

40 CFR 427.40 - Applicability; description of the asbestos paper (elastomeric binder) subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... asbestos paper (elastomeric binder) subcategory. 427.40 Section 427.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Elastomeric Binder) Subcategory § 427.40 Applicability; description of...

Grade determination of crumb rubber-modified performance graded asphalt binder.

DOT National Transportation Integrated Search

2013-08-01

Due to particulates common in crumb rubber-modified asphalt binders, conventional PG grading using the Dynamic Shear Rheometer (DSR) with a gap height of 1.0 mm may not be valid and in accordance with current specifications. Asphalt binder testing an...

Grade determination of crumb rubber-modified performance graded asphalt binder.

DOT National Transportation Integrated Search

2013-08-01

Due to particulates common in crumb rubber-modified asphalt binders, conventional PG grading using the Dynamic : Shear Rheometer (DSR) with a gap height of 1.0 mm may not be valid and in accordance with current specifications. : Asphalt binder testin...

Effect of asphalt rejuvenating agent on aged reclaimed asphalt pavement and binder properties.

DOT National Transportation Integrated Search

2016-11-01

Hot in-place recycling (HIR) preserves distressed asphalt pavements while minimizing use of virgin binder : and aggregates. The final quality of an HIR mixture depends on the characteristics of the original binder, aging of the : pavement surface dur...

Wetting characteristics of asphalt binders at mixing temperatures.

DOT National Transportation Integrated Search

2013-10-01

Conventional hot mix asphalt (HMA) is produced by heating the aggregate and the asphalt binder to elevated : temperatures that are typically in the range of 150C to 160C. These temperatures ensure that the viscosity of the : asphalt binder is low eno...

Development of binder test to determine fracture energy [summary].

DOT National Transportation Integrated Search

2012-04-01

Asphalt binder makes up a relatively small percentage 4% to 8% of the hot mix asphalt used in pavements, but its performance as a binder is critical to the longevity of road surfaces. Asphalt is : a material whose flexibility changes with : t...

New agent to treat elevated phosphate levels: magnesium carbonate/calcium carbonate tablets.

PubMed

Meyer, Caitlin; Cameron, Karen; Battistella, Marisa

2012-01-01

In summary, Binaphos CM, a magnesium carbonate/calcium carbonate combination phosphate binder, is marketed for treating elevated phosphate levels in dialysis patients. Although studies using magnesium/calcium carbonate as a phosphate binder are short term with small numbers of patients, this phosphate binder has shown some promising results and may provide clinicians with an alternative for phosphate binding. Using a combination phosphate binder may reduce pill burden and encourage patient compliance. In addition to calcium and phosphate, it is imperative to diligently monitor magnesium levels in patients started on this medication, as magnesium levels may increase with longer duration of use. Additional randomized controlled trials are necessary to evaluate long-term efficacy and safety of this combination phosphate binder.

Nanoporous Ru as a carbon- and binder-free cathode for Li-O2 batteries.

PubMed

Liao, Kaiming; Zhang, Tao; Wang, Yongqing; Li, Fujun; Jian, Zelang; Yu, Haijun; Zhou, Haoshen

2015-04-24

Porous carbon-free cathodes are critical to achieve a high discharge capacity and efficient cycling for rechargeable Li-O2 battery. Herein, we present a very simple method to directly grow nanoporous Ru (composed of polycrystalline particles of ∼5 nm) on one side of a current collector of Ni foam via a galvanic replacement reaction. The resulting Ru@Ni can be employed as a carbon- and binder-free cathode for Li-O2 batteries and delivers a specific capacity of 3720 mAh gRu (-1) at a current density of 200 mA gRu (-1) . 100 cycles of continuous discharge and charge are obtained at a very narrow terminal voltage window of 2.75∼3.75 V with a limited capacity of 1000 mAh gRu (-1) . The good performance of the nanoporous Ru@Ni cathode can be mainly attributed to the effective suppression of the by-products related to carbon or binder, the good adhesion of the catalyst to the current collector, and the good permeation of O2 and electrolyte into the active sites of the nanoporous Ru with the open pore system. This new type electrode provides a snapshot toward developing high-performance carbon- and binder-free Li-O2 batteries. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

40 CFR 427.30 - Applicability; description of the asbestos paper (starch binder) subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... asbestos paper (starch binder) subcategory. 427.30 Section 427.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Starch Binder) Subcategory § 427.30 Applicability; description of the...

40 CFR 427.30 - Applicability; description of the asbestos paper (starch binder) subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... asbestos paper (starch binder) subcategory. 427.30 Section 427.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Starch Binder) Subcategory § 427.30 Applicability; description of the...

40 CFR 427.30 - Applicability; description of the asbestos paper (starch binder) subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... asbestos paper (starch binder) subcategory. 427.30 Section 427.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Starch Binder) Subcategory § 427.30 Applicability; description of the...

40 CFR 427.30 - Applicability; description of the asbestos paper (starch binder) subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... asbestos paper (starch binder) subcategory. 427.30 Section 427.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Starch Binder) Subcategory § 427.30 Applicability; description of the asbestos paper...

40 CFR 427.30 - Applicability; description of the asbestos paper (starch binder) subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... asbestos paper (starch binder) subcategory. 427.30 Section 427.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Starch Binder) Subcategory § 427.30 Applicability; description of the asbestos paper...

Mechanical Properties of Warm Mix Asphalt Prepared Using Foamed Asphalt Binders : Executive Summary Report

DOT National Transportation Integrated Search

2011-03-01

Hot mix asphalt (HMA) is a mixture containing aggregates and asphalt binders prepared at specified : proportions. The aggregates and asphalt binder proportions are determined through a mix design : procedure such as the Marshall Mix Design or the Sup...

Mechanical properties of warm mix asphalt prepared using foamed asphalt binders : executive summary report.

DOT National Transportation Integrated Search

2011-03-01

Hot mix asphalt (HMA) is a mixture containing aggregates and asphalt binders prepared at specified : proportions. The aggregates and asphalt binder proportions are determined through a mix design : procedure such as the Marshall Mix Design or the Sup...

Validity of multiple stress creep recovery test for LADOTD asphalt binder specification.

DOT National Transportation Integrated Search

2010-09-01

The objectives of this research are to characterize the elastic response of various binders used by LADOTD to determine the feasibility of the Multiple Stress Creep Recovery (MSCR) test to be included in the LADOTD asphalt binder specification and to...

Effect of asphalt rejuvenating agent on aged reclaimed asphalt pavement and binder properties : technical summary.

DOT National Transportation Integrated Search

2016-11-01

Hot in-place recycling (HIR) preserves distressed asphalt pavements while minimizing use of virgin binder and aggregates. The final quality of an HIR mixture depends on the characteristics of the original binder, aging of the pavement surface during ...

46 CFR 308.544 - Facultative binder, Form MA-315.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Facultative War Risk Cargo Insurance § 308.544 Facultative binder, Form MA-315. The standard form of War Risk Facultative Cargo Binder, which may be obtained from MARAD's...

47 CFR 51.232 - Binder group management.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Binder group management. 51.232 Section 51.232 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) INTERCONNECTION Obligations of All Local Exchange Carriers § 51.232 Binder group management. (a) With the exception of loops...

Cortisol-21-sulfate (FS) is a specific ligand for intracellular transcortin: demonstration of three types of high affinity corticosteroid binders in bovine aortic cytosol by a combined use of FS and RU 28362.

PubMed

Hayashi, T; Kornel, L

1990-01-01

This paper reports the results of a study on the binding of adrenal steroids in bovine aortic tissue. Using the same method as in our previous study of mineralocorticoid and glucocorticoid binding in rabbit arterial cytosol, we could not demonstrate in the bovine aorta the three types of high affinity binders for these steroids, which we found in the rabbit arteries. In the search for specific markers for each of the three types of binders (glucocorticoid and mineralocorticoid receptors and the transcortin-like intracellular binder), we have found that a conjugated steroid, cortisol-21-sulfate, binds preferentially to the transcortin-like binder, but not to the two receptors. Using this steroid, in combination with the pure synthetic glucocorticoid RU 28362, we were able to clearly discriminate between the three types of corticosteroid binders in bovine aorta.

Performance analysis of flexible DSSC with binder addition

NASA Astrophysics Data System (ADS)

Muliani, Lia; Hidayat, Jojo; Anggraini, Putri Nur

2016-04-01

Flexible DSSC is one of modification of DSSC based on its substrate. Operating at low temperature, flexible DSSC requires a binder to improve particles interconnection. This research was done to compare the morphology and performance of flexible DSSC that was produced with binder-added and binder-free. TiO2 powder, butanol, and HCl were mixed for preparation of TiO2 paste. Small amount of titanium isopropoxide as binder was added into the mixture. TiO2 paste was deposited on ITO-PET plastic substrate with area of 1x1 cm2 by doctor blade method. Furthermore, SEM, XRD, and BET characterization were done to analyze morphology and surface area of the TiO2 photoelectrode microstructures. Dyed TiO2 photoelectrode and platinum counter electrode were assembled and injected by electrolyte. In the last process, flexible DSSCs were illuminated by sun simulator to do J-V measurement. As a result, flexible DSSC containing binder showed higher performance with photoconversion efficiency of 0.31%.

Remarkable Effect of Sodium Alginate Aqueous Binder on Anatase TiO2 as High-Performance Anode in Sodium Ion Batteries.

PubMed

Ling, Liming; Bai, Ying; Wang, Zhaohua; Ni, Qiao; Chen, Guanghai; Zhou, Zhiming; Wu, Chuan

2018-02-14

Sodium alginate (SA) is investigated as the aqueous binder to fabricate high-performance, low-cost, environmentally friendly, and durable TiO 2 anodes in sodium-ion batteries (SIBs) for the first time. Compared to the conventional polyvinylidene difluoride (PVDF) binder, electrodes using SA as the binder exhibit significant promotion of electrochemical performances. The initial Coulombic efficiency is as high as 62% at 0.1 C. A remarkable capacity of 180 mAh g -1 is achieved with no decay after 500 cycles at 1 C. Even at 10 C (3.4 A g -1 ), it remains 82 mAh g -1 after 3600 cycles with approximate 100% Coulombic efficiency. TiO 2 electrodes with SA binder display less electrolyte decomposition, fewer side reactions, high electrochemistry reaction activity, effective suppression of polarization, and good electrode morphology, which is ascribed to the rich carboxylic groups, high Young's modulus, and good electrochemical stability of SA binder.

Effect of microstructure on the coupled electromagnetic-thermo-mechanical response of cyclotrimethylenetrinitramine-estane energetic aggregates to infrared laser radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Judith A.; Zikry, M. A., E-mail: zikry@ncsu.edu

2015-09-28

The coupled electromagnetic (EM)-thermo-mechanical response of cyclotrimethylenetrinitramine-estane energetic aggregates under laser irradiation and high strain rate loads has been investigated for various aggregate sizes and binder volume fractions. The cyclotrimethylenetrinitramine (RDX) crystals are modeled with a dislocation density-based crystalline plasticity formulation and the estane binder is modeled with finite viscoelasticity through a nonlinear finite element approach that couples EM wave propagation with laser heat absorption, thermal conduction, and inelastic deformation. Material property and local behavior mismatch at the crystal-binder interfaces resulted in geometric scattering of the EM wave, electric field and laser heating localization, high stress gradients, dislocation density, andmore » crystalline shear slip accumulation. Viscous sliding in the binder was another energy dissipation mechanism that reduced stresses in aggregates with thicker binder ligaments and larger binder volume fractions. This investigation indicates the complex interactions between EM waves and mechanical behavior, for accurate predictions of laser irradiation of heterogeneous materials.« less

Transparent superhydrophobic surfaces using a spray coating process

DOE PAGES

Polyzos, Georgios; Jang, Gyoung Gug; Smith, D. Barton; ...

2017-11-03

One significant maintenance problem and cost associated with solar energy conversion systems is the soiling due to the accumulation of dust and other pollutants. Here in this work, we describe a scalable approach for applying antisoiling coatings based on superhydrophobic (SH) silica particles using a spray coating process. A large water contact angle (WCA) is one of the characteristics of excellent SH surfaces and because of the low surface energy and low adhesion forces the soiling rate is reduced. Our findings indicate that the WCA depends strongly on the ratio of the polymer binder and the nanoparticles. The nanoparticle surfacemore » coverage of the spray coated samples was substantially improved after rinsing with solvent. This process tended to remove large aggregates and excess polymer binder and further increased the WCA by allowing exposure of the functionalized nanoparticles. The durability of the SH coatings was enhanced when the substrate was pretreated with polymer binder and an optimal curing time between 30 and 60 min. The abrasion tests of the SH coatings we report in this study showed that the WCA decreased from ~ 166° to ~ 157° after exposure to 2.6 g of sand. Such coatings will help reduce costs of periodic cleaning of solar energy conversion systems (photovoltaic panels and concentrated solar mirrors).« less

Elucidating the Polymeric Binder Distribution within Lithium-ion Battery Electrodes Using SAICAS.

PubMed

Kim, Kyuman; Byun, Seoungwoo; Choi, Jaecheol; Hong, Seungbum; Ryou, Myung-Hyun; Lee, Yong Min

2018-03-30

Polymeric binder distribution within electrodes is crucial to guarantee the electrochemical performance of lithium-ion batteries (LIBs) for their long-term use in applications such as electric vehicles and energy-storage systems. However, due to limited analytical tools, such analyses have not been conducted so far. Herein, the adhesion properties of LIB electrodes at different depths are measured using a surface and interfacial cutting analysis system (SAICAS). Moreover, two LiCoO 2 electrodes, dried at 130 and 230 °C, are carefully prepared and used to obtain the adhesion properties at every 10 μm of depth as well as the interface between the electrode composite and the current collector. At high drying temperatures, more of the polymeric binder material and conductive agent appears adjacent to the electrode surface, resulting in different adhesion properties as a function of depth. When the electrochemical properties are evaluated at different temperatures, the LiCoO 2 electrode dried at 130 °C shows a much better high-temperature cycling performance than does the electrode dried at 230 °C due to the uniform adhesion properties and the higher interfacial adhesion strength. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Transparent superhydrophobic surfaces using a spray coating process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Polyzos, Georgios; Jang, Gyoung Gug; Smith, D. Barton

One significant maintenance problem and cost associated with solar energy conversion systems is the soiling due to the accumulation of dust and other pollutants. Here in this work, we describe a scalable approach for applying antisoiling coatings based on superhydrophobic (SH) silica particles using a spray coating process. A large water contact angle (WCA) is one of the characteristics of excellent SH surfaces and because of the low surface energy and low adhesion forces the soiling rate is reduced. Our findings indicate that the WCA depends strongly on the ratio of the polymer binder and the nanoparticles. The nanoparticle surfacemore » coverage of the spray coated samples was substantially improved after rinsing with solvent. This process tended to remove large aggregates and excess polymer binder and further increased the WCA by allowing exposure of the functionalized nanoparticles. The durability of the SH coatings was enhanced when the substrate was pretreated with polymer binder and an optimal curing time between 30 and 60 min. The abrasion tests of the SH coatings we report in this study showed that the WCA decreased from ~ 166° to ~ 157° after exposure to 2.6 g of sand. Such coatings will help reduce costs of periodic cleaning of solar energy conversion systems (photovoltaic panels and concentrated solar mirrors).« less

Development of Nanoporous Carbide-Derived Carbon Electrodes for High-Performance Lithium-Ion Batteries

DTIC Science & Technology

2011-09-01

carbon produced from TiC (From [10]). .................................... 27 Figure 9. LiFePO4 , acetylene black, and PVDF powders in weighing boat...dispenser, and the ball milled powder mixture x containing LiFePO4 , acetylene black, and PVDF binder; and b) Prepared slurry after adding NMP solvent to...the powder mixture. ..... 39 Figure 12. Sample vial containing a LiFePO4 slurry inside the ultrasonic bath. Each vial was sonicated for 30 minutes

Generic Biocombinatorial Strategy to Select Tailor-Made Stabilizers for Sol-Gel Nanoparticle Synthesis.

PubMed

Hanßke, Felix; Kemnitz, Erhard; Börner, Hans G

2015-09-09

A generic route for the selection of nanoparticle stabilizers via biocombinatorial means of phage display peptide screening is presented, providing magnesium fluoride nanoparticle synthesis as example. Selected sequence-specific MgF2 binders are evaluated for their adsorption behavior. Peptide-polymer conjugates derived from the best binding peptide are used for the stabilization of MgF2 sol nanoparticles, yielding fully redispersable dry states and improoving processability significantly. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effect of polymer binders in anode catalyst layer on performance of alkaline direct ethanol fuel cells

NASA Astrophysics Data System (ADS)

Li, Y. S.; Zhao, T. S.; Liang, Z. X.

In preparing low-temperature fuel cell electrodes, a polymer binder is essential to bind discrete catalyst particles to form a porous catalyst layer that simultaneously facilitates the transfer of ions, electrons, and reactants/products. For two types of polymer binder, namely, an A3-an anion conducting ionomer and a PTFE-a neutral polymer, an investigation is made of the effect of the content of each binder in the anode catalyst layer on the performance of an alkaline direct ethanol fuel cell (DEFC) with an anion-exchange membrane and non-platinum (non-Pt) catalysts. Experiments are performed by feeding either ethanol (C 2H 5OH) solution or ethanol-potassium hydroxide (C 2H 5OH-KOH) solution. The experimental results for the case of feeding C 2H 5OH solution without added KOH indicate that the cell performance varies with the A3 ionomer content in the anode catalyst layer, and a content of 10 wt.% exhibits the best performance. When feeding C 2H 5OH-KOH solution, the results show that: (i) in the region of low current density, the best performance is achieved for a membrane electrode assembly without any binder in the anode catalyst layer; (ii) in the region of high current density, the performance is improved with incorporation of PTFE binder in the anode catalyst layer; (iii) the PTFE binder yields better performance than does the A3 binder.

ATTRITION RESISTANT IRON-BASED FISCHER-TROPSCH CATALYSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

James G. Goodwin, Jr.; James J. Spivey; K. Jothimurugesan

1999-03-29

The Fischer-Tropsch (F-T) reaction provides a way of converting coal-derived synthesis gas (CO+H{sub 2}) to liquid fuels. Since the reaction is highly exothermic, one of the major problems in control of the reaction is heat removal. Recent work has shown that the use of slurry bubble column reactors (SBCRs) can largely solve this problem. Iron-based (Fe) catalysts are preferred catalysts for F-T when using low CO/H2 ratio synthesis gases derived from modern coal gasifiers. This is because in addition to reasonable F-T activity, the F-T catalysts also possess high water gas shift (WGS) activity. However, a serious problem with themore » use of Fe catalysts in a SBCR is their tendency to undergo attrition. This can cause fouling/plugging of downstream filters and equipment, making the separation of catalyst from the oil/wax product very difficult if not impossible, and results in a steady loss of catalyst from the reactor. The objectives of this research are to develop a better understanding of the parameters affecting attrition resistance of Fe F-T catalysts suitable for use in SBCRs and to incorporate this understanding into the design of novel Fe catalysts having superior attrition resistance. Catalyst preparations will be based on the use of spray drying and will be scalable using commercially available equipment. The research will employ among other measurements, attrition testing and F-T synthesis, including long duration slurry reactor runs in order to ascertain the degree of success of the various preparations. The goal is to develop an Fe catalyst which can be used in a SBCR having only an internal filter for separation of the catalyst from the liquid product, without sacrificing F-T activity and selectivity. The effect of silica addition via coprecipitation and as a binder to a doubly promoted Fischer-Tropsch synthesis iron catalyst (100 Fe/5 Cu/4.2 K) was studied. The catalysts were prepared by coprecipitation, followed by binder addition and drying in a 1 m diameter, 2 m tall spray dryer. The binder silica content was varied from 0 to 20 wt %. A catalyst with 12 wt % binder silica was found to have the highest attrition resistance. F-T reaction studies over 100 hours in a fixed-bed reactor showed that this catalyst maintained around 95 % CO conversion with a methane selectivity of less than 7 wt % and a C5 + selectivity of greater than 73 wt %. The effect of adding precipitated silica from 0 to 20 parts by weight to this catalyst (containing 12 wt % binder silica) was also studied. Addition of precipitated silica was found to be detrimental to attrition resistance and resulted in increased methane and reduced wax formation. An HPR series of proprietary catalysts was prepared to further improve the attrition resistance. Based on the experience gained, a proprietary HPR-43 catalyst has been successfully spray dried in 500 g quantity. This catalyst showed 95 % CO conversion over 125 h and had less than 4 % methane selectivity. Its attrition resistance was one of the highest among the catalyst tested.« less

Magnesium-based methods, systems, and devices

DOEpatents

Zhao, Yufeng; Ban, Chunmei; Ruddy, Daniel; Parilla, Philip A.; Son, Seoung-Bum

2017-12-12

An aspect of the present invention is an electrical device, where the device includes a current collector and a porous active layer electrically connected to the current collector to form an electrode. The porous active layer includes MgB.sub.x particles, where x.gtoreq.1, mixed with a conductive additive and a binder additive to form empty interstitial spaces between the MgB.sub.x particles, the conductive additive, and the binder additive. The MgB.sub.x particles include a plurality of boron sheets of boron atoms covalently bound together, with a plurality of magnesium atoms reversibly intercalated between the boron sheets and ionically bound to the boron atoms.

Space stable thermal control coatings

NASA Technical Reports Server (NTRS)

Harada, Y.

1982-01-01

A specification quality zinc orthotitanate coating was developed. This silicate-bonded Zn2TiO4 coating is discussed. The effects of precursor chemistry, precursor mixing procedures, stoichiometry variations, and of different heat treatments on the physical and optical properties of Zn2TiO4 are investigated. Inorganic silicates are compared to organic silicone binder systems. The effects of pigment to binder ratio, water content, and of different curing procedures on the optical and physical properties of Zn2TiO4 potassium silicate coatings are also studied. Environmental tests were conducted to determine the UV vacuum stability of coatings for durations up to 5000 equivalent Sun hours.

Field test of a polyphosphoric acid (PPA) modified asphalt binder on Rt. 1 in Perry.

DOT National Transportation Integrated Search

2013-04-01

The Maine Department of Transportation (MaineDOT) uses the Superpave hot mix asphalt process and : specifies asphalt binder grades using the Performance Grade criteria. The Department mainly uses asphalt : binder grade PG 64-28. This is an asphalt bi...

44 CFR 61.13 - Standard Flood Insurance Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... use. (e) Oral and written binders. No oral binder or contract shall be effective. No written binder shall be effective unless issued with express authorization of the Federal Insurance Administrator. (f...” (WYO) property insurance companies, based upon flood insurance applications and renewal forms, all of...

Evaluation of binder aging and its influence in aging of hot mix asphalt concrete : literature review and experimental design.

DOT National Transportation Integrated Search

2009-02-01

Binder oxidation in pavements and its impact on pavement performance has been addressed by : numerous laboratory studies of binder oxidation chemistry, reaction kinetics, and hardening and its impact on : mixture fatigue. Studies also have included s...

46 CFR 308.544 - Facultative binder, Form MA-315.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.544 Facultative binder, Form MA-315. The standard form of War Risk Facultative Cargo Binder, which may be obtained from the American War...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 8 2014-10-01 2014-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.544 - Facultative binder, Form MA-315.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.544 Facultative binder, Form MA-315. The standard form of War Risk Facultative Cargo Binder, which may be obtained from the American War...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.544 - Facultative binder, Form MA-315.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.544 Facultative binder, Form MA-315. The standard form of War Risk Facultative Cargo Binder, which may be obtained from the American War...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.544 - Facultative binder, Form MA-315.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.544 Facultative binder, Form MA-315. The standard form of War Risk Facultative Cargo Binder, which may be obtained from the American War...

Theme Binders: One Size Fits All.

ERIC Educational Resources Information Center

Baskwill, Steve

1996-01-01

Describes theme binders designed by sixth graders as an independent study component that unites the class as a learning community, showcases student work, and illustrates developmental milestones for parents. Details theme binder components: (1) cover page; (2) introductory page outlining the theme and contents; (3) evaluation sections indicating…

Effect of Reclaimed Asphalt Pavement on Binder Properties Using the Superpave System

DOT National Transportation Integrated Search

1998-09-01

While the use of reclaimed asphalt pavement (RAP) in asphalt mixes is common practice within many state departments of transportation, the evolution of the Superpave system has prompted a need for specific Superpave guidelines for the use of RAP. In ...

76 FR 64115 - Privacy Act of 1974; Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

...-leaf binders or file folders, and in electronic media, including NASA's Ethics Program Tracking System... documents, electronic media, micrographic media, photographs, or motion pictures film, and various medical....; General Accounting Office's General Policies/Procedures and Communications Manual, Chapter 7; Treasury...

Energy and Resource-Saving Sources of Energy in Small Power Engineering of Siberia

NASA Astrophysics Data System (ADS)

Baranova, Marina

2017-11-01

The sustainable development of distant areas of Siberia is associated with the structures of energy demand and supply, the implementation and promotion of the process of environmentally safe restructuring of the energy supply system. It has been established that suspension coal fuels derived from brown coal, coal mining, coal processing wastes can be used as fuel. The results of experimental and industrial boilers on suspension water coal fuel are presented. The designs of vortex combustion chambers of various powers are developed and tested. The possibility of using coal-enrichment wastes and substandard coals for the production of manure-coal fuel briquettes was studied. It is shown that the strength and thermal power characteristics of briquettes depend on the moisture content and degree of metamorphism of the raw materials. The most effective percentage of the solid phase and manure, as a binder, was determined.

VISCOSITY AND BINDER COMPOSITION EFFECTS ON TYROSINASE-BASED CARBON PASTE ELECTRODE FOR DETECTION OF PHENOL AND CATECHOL

EPA Science Inventory

The systematic study of the effect of binder viscosity on the sensitivity of a tyrosinase-based carbon paste electrode (CPE) biosensor for phenol and catechol is reported. Silicon oil binders with similar (polydimethylsiloxane) chemical composition were used to represent a wid...

Field test of a polyphosphoric acid (PPA) modified asphalt binder on Rt. 1 in Perry : [second interim report, April 2012].

DOT National Transportation Integrated Search

2012-04-01

The Maine Department of Transportation (MaineDOT) uses the Superpave hot mix asphalt process and : specifies asphalt binder grades using the Performance Grade criteria. The Department mainly uses asphalt : binder grade PG64-28. This is an asphalt bin...

Redox-Active Supramolecular Polymer Binders for Lithium–Sulfur Batteries That Adapt Their Transport Properties in Operando

DOE PAGES

Frischmann, Peter D.; Hwa, Yoon; Cairns, Elton J.; ...

2016-10-25

π-Stacked perylene bisimide (PBI) molecules are implemented here as highly networked, redox-active supramolecular polymer binders in sulfur cathodes for lightweight and energy-dense Li-S batteries. We show that the in operando reduction and lithiation of these PBI binders sustainably reduces Li-S cell impedance relative to nonredox active conventional polymer binders. This lower impedance enables high-rate cycling in Li-S cells with excellent durability, a critical step toward unlocking the full potential of Li-S batteries for electric vehicles and aviation.

Binder-Free V 2 O 5 Cathode for Greener Rechargeable Aluminum Battery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Huali; Bai, Ying; Chen, Shi

This letter reports on the investigation of a binder-free cathode material to be used in rechargeable aluminum batteries. This cathode is synthesized by directly depositing V2O5 on a Ni foam current collector. Rechargeable aluminum coin cells fabricated using the as-synthesized binder-free cathode delivered an initial discharge capacity of 239 mAh/g, which is much higher than that of batteries fabricated using a cathode composed of V2O5 nanowires and binder. An obvious discharge voltage plateau appeared at 0.6 V in the discharge curves of the Ni–V2O5 cathode, which is slightly higher than that of the V2O5 nanowire cathodes with common binders. Thismore » improvement is attributed to reduced electrochemical polarization.« less

Factors affecting hazardous waste solidification/stabilization: a review.

PubMed

Malviya, Rachana; Chaudhary, Rubina

2006-09-01

Solidification/stabilization is accepted as a well-established disposal technique for hazardous waste. As a result many different types of hazardous wastes are treated with different binders. The S/S products have different property from waste and binders individually. The effectiveness of S/S process is studied by physical, chemical and microstructural methods. This paper summarizes the effect of different waste stream such as heavy metals bearing sludge, filter cake, fly ash, and slag on the properties of cement and other binders. The factors affecting strength development is studied using mix designs, including metal bearing waste alters the hydration and setting time of binders. Pore structure depends on relative quantity of the constituents, cement hydration products and their reaction products with admixtures. Carbonation and additives can lead to strength improvement in waste-binder matrix.

Method of making bonded or sintered permanent magnets

DOEpatents

McCallum, R.W.; Dennis, K.W.; Lograsso, B.K.; Anderson, I.E.

1993-08-31

An isotropic permanent magnet is made by mixing a thermally responsive, low viscosity binder and atomized rare earth-transition metal (e.g., iron) alloy powder having a carbon-bearing (e.g., graphite) layer thereon that facilitates wetting and bonding of the powder particles by the binder. Prior to mixing with the binder, the atomized alloy powder may be sized or classified to provide a particular particle size fraction having a grain size within a given relatively narrow range. A selected particle size fraction is mixed with the binder and the mixture is molded to a desired complex magnet shape. A molded isotropic permanent magnet is thereby formed. A sintered isotropic permanent magnet can be formed by removing the binder from the molded mixture and thereafter sintering to full density.

Method of making bonded or sintered permanent magnets

DOEpatents

McCallum, R.W.; Dennis, K.W.; Lograsso, B.K.; Anderson, I.E.

1995-11-28

An isotropic permanent magnet is made by mixing a thermally responsive, low viscosity binder and atomized rare earth-transition metal (e.g., iron) alloy powder having a carbon-bearing (e.g., graphite) layer thereon that facilitates wetting and bonding of the powder particles by the binder. Prior to mixing with the binder, the atomized alloy powder may be sized or classified to provide a particular particle size fraction having a grain size within a given relatively narrow range. A selected particle size fraction is mixed with the binder and the mixture is molded to a desired complex magnet shape. A molded isotropic permanent magnet is thereby formed. A sintered isotropic permanent magnet can be formed by removing the binder from the molded mixture and thereafter sintering to full density. 14 figs.

Method of making bonded or sintered permanent magnets

DOEpatents

McCallum, R. William; Dennis, Kevin W.; Lograsso, Barbara K.; Anderson, Iver E.

1995-11-28

An isotropic permanent magnet is made by mixing a thermally responsive, low viscosity binder and atomized rare earth-transition metal (e.g., iron) alloy powder having a carbon-bearing (e.g., graphite) layer thereon that facilitates wetting and bonding of the powder particles by the binder. Prior to mixing with the binder, the atomized alloy powder may be sized or classified to provide a particular particle size fraction having a grain size within a given relatively narrow range. A selected particle size fraction is mixed with the binder and the mixture is molded to a desired complex magnet shape. A molded isotropic permanent magnet is thereby formed. A sintered isotropic permanent magnet can be formed by removing the binder from the molded mixture and thereafter sintering to full density.

Mesoscale Effective Property Simulations Incorporating Conductive Binder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trembacki, Bradley L.; Noble, David R.; Brunini, Victor E.

Lithium-ion battery electrodes are composed of active material particles, binder, and conductive additives that form an electrolyte-filled porous particle composite. The mesoscale (particle-scale) interplay of electrochemistry, mechanical deformation, and transport through this tortuous multi-component network dictates the performance of a battery at the cell-level. Effective electrode properties connect mesoscale phenomena with computationally feasible battery-scale simulations. We utilize published tomography data to reconstruct a large subsection (1000+ particles) of an NMC333 cathode into a computational mesh and extract electrode-scale effective properties from finite element continuum-scale simulations. We present a novel method to preferentially place a composite binder phase throughout the mesostructure,more » a necessary approach due difficulty distinguishing between non-active phases in tomographic data. We compare stress generation and effective thermal, electrical, and ionic conductivities across several binder placement approaches. Isotropic lithiation-dependent mechanical swelling of the NMC particles and the consideration of strain-dependent composite binder conductivity significantly impact the resulting effective property trends and stresses generated. Lastly, our results suggest that composite binder location significantly affects mesoscale behavior, indicating that a binder coating on active particles is not sufficient and that more accurate approaches should be used when calculating effective properties that will inform battery-scale models in this inherently multi-scale battery simulation challenge.« less

Mesoscale Effective Property Simulations Incorporating Conductive Binder

DOE PAGES

Trembacki, Bradley L.; Noble, David R.; Brunini, Victor E.; ...

2017-07-26

Lithium-ion battery electrodes are composed of active material particles, binder, and conductive additives that form an electrolyte-filled porous particle composite. The mesoscale (particle-scale) interplay of electrochemistry, mechanical deformation, and transport through this tortuous multi-component network dictates the performance of a battery at the cell-level. Effective electrode properties connect mesoscale phenomena with computationally feasible battery-scale simulations. We utilize published tomography data to reconstruct a large subsection (1000+ particles) of an NMC333 cathode into a computational mesh and extract electrode-scale effective properties from finite element continuum-scale simulations. We present a novel method to preferentially place a composite binder phase throughout the mesostructure,more » a necessary approach due difficulty distinguishing between non-active phases in tomographic data. We compare stress generation and effective thermal, electrical, and ionic conductivities across several binder placement approaches. Isotropic lithiation-dependent mechanical swelling of the NMC particles and the consideration of strain-dependent composite binder conductivity significantly impact the resulting effective property trends and stresses generated. Lastly, our results suggest that composite binder location significantly affects mesoscale behavior, indicating that a binder coating on active particles is not sufficient and that more accurate approaches should be used when calculating effective properties that will inform battery-scale models in this inherently multi-scale battery simulation challenge.« less

Modelling and Laboratory Studies on the Adhesion Fatigue Performance for Thin-Film Asphalt and Aggregate System

PubMed Central

Wang, Dongsheng; Feng, Decheng

2014-01-01

Adhesion between asphalt and aggregate plays an important role in the performance of asphalt mixtures. A low-frequency adhesion fatigue test was proposed in this paper to study the effect of environment on the asphalt-aggregate adhesion system. The stress-based fatigue model had been utilized to describe the fatigue behavior of thin-film asphalt and aggregate system. The factors influencing the adhesion fatigue performance were also investigated. Experiment results show that asphalt has more important effect on the adhesion performance comparing with aggregate. Basalt, which is regarded as hydrophobic aggregates with low silica content, has better adhesion performance to asphalt binder when compared with granite. The effects of aging on the adhesion fatigue performance are different for PG64-22 and rubber asphalt. Long-term aging is found to reduce the adhesion fatigue lives for rubber asphalt and aggregate system, while the effect of long-term aging for aggregate and PG64-22 binder system is positive. Generally the increased stress amplitude and test temperature could induce greater damage and lead to less fatigue lives for adhesion test system. PMID:25054187

Modelling and laboratory studies on the adhesion fatigue performance for thin-film asphalt and aggregate system.

PubMed

Wang, Dongsheng; Yi, Junyan; Feng, Decheng

2014-01-01

Adhesion between asphalt and aggregate plays an important role in the performance of asphalt mixtures. A low-frequency adhesion fatigue test was proposed in this paper to study the effect of environment on the asphalt-aggregate adhesion system. The stress-based fatigue model had been utilized to describe the fatigue behavior of thin-film asphalt and aggregate system. The factors influencing the adhesion fatigue performance were also investigated. Experiment results show that asphalt has more important effect on the adhesion performance comparing with aggregate. Basalt, which is regarded as hydrophobic aggregates with low silica content, has better adhesion performance to asphalt binder when compared with granite. The effects of aging on the adhesion fatigue performance are different for PG64-22 and rubber asphalt. Long-term aging is found to reduce the adhesion fatigue lives for rubber asphalt and aggregate system, while the effect of long-term aging for aggregate and PG64-22 binder system is positive. Generally the increased stress amplitude and test temperature could induce greater damage and lead to less fatigue lives for adhesion test system.

Phage display biopanning and isolation of target-unrelated peptides: in search of nonspecific binders hidden in a combinatorial library.

PubMed

Bakhshinejad, Babak; Zade, Hesam Motaleb; Shekarabi, Hosna Sadat Zahed; Neman, Sara

2016-12-01

Phage display is known as a powerful methodology for the identification of targeting ligands that specifically bind to a variety of targets. The high-throughput screening of phage display combinatorial peptide libraries is performed through the affinity selection method of biopanning. Although phage display selection has proven very successful in the discovery of numerous high-affinity target-binding peptides with potential application in drug discovery and delivery, the enrichment of false-positive target-unrelated peptides (TUPs) without any actual affinity towards the target remains a major problem of library screening. Selection-related TUPs may emerge because of binding to the components of the screening system rather than the target. Propagation-related TUPs may arise as a result of faster growth rate of some phage clones enabling them to outcompete slow-propagating clones. Amplification of the library between rounds of biopanning makes a significant contribution to the selection of phage clones with propagation advantage. Distinguishing nonspecific TUPs from true target binders is of particular importance for the translation of biopanning findings from basic research to clinical applications. Different experimental and in silico approaches are applied to assess the specificity of phage display-derived peptides towards the target. Bioinformatic tools are playing a rapidly growing role in the analysis of biopanning data and identification of target-irrelevant TUPs. Recent progress in the introduction of efficient strategies for TUP detection holds enormous promise for the discovery of clinically relevant cell- and tissue-homing peptides and paves the way for the development of novel targeted diagnostic and therapeutic platforms in pharmaceutical areas.

Capabilities and limitations of handheld Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) for the analysis of colourants and binders in 20th-century reverse paintings on glass.

PubMed

Steger, Simon; Stege, Heike; Bretz, Simone; Hahn, Oliver

2018-04-15

A non-invasive method has been carried out to show the capabilities and limitations of Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) for identifying of colourants and binders in modern reverse glass paintings. For this purpose, the reverse glass paintings "Zwei Frauen am Tisch" (1920-22), "Bäume" (1946) (both by Heinrich Campendonk), "Lofoten" (1933) (Edith Campendonk-van Leckwyck) and "Ohne Titel" (1954) (Marianne Uhlenhuth), were measured. In contrast to other techniques (e.g. panel and mural painting), the paint layers are applied in reverse succession. In multi-layered paint systems, the front paint layer may no longer be accessible. The work points out the different spectral appearance of a given substance (gypsum, basic lead white) in reverse glass paintings. However, inverted bands, band overlapping and derivative-shaped spectral features can be interpreted by comparing the spectra from the paintings with spectra from pure powders and pigment/linseed oil mock-ups. Moreover, the work focuses on this method's capabilities in identifying synthetic organic pigments (SOP). Reference spectra of three common SOP (PG7, PY1, PR83) were obtained from powders and historical colour charts. We identified PR83 and PY1 in two reverse glass paintings, using the measured reference spectra. The recorded DRIFTS spectra of pure linseed oil, gum Arabic, mastic, polyvinyl acetate resin and bees wax can be used to classify the binding media of the measured paintings. Copyright © 2018 Elsevier B.V. All rights reserved.

Bacterial-cellulose-derived interconnected meso-microporous carbon nanofiber networks as binder-free electrodes for high-performance supercapacitors

NASA Astrophysics Data System (ADS)

Hao, Xiaodong; Wang, Jie; Ding, Bing; Wang, Ya; Chang, Zhi; Dou, Hui; Zhang, Xiaogang

2017-06-01

Bacterial cellulose (BC), a typical biomass prepared from the microbial fermentation process, has been proved that it can be an ideal platform for design of three-dimensional (3D) multifunctional nanomaterials in energy storage and conversion field. Here we developed a simple and general silica-assisted strategy for fabrication of interconnected 3D meso-microporous carbon nanofiber networks by confine nanospace pyrolysis of sustainable BC, which can be used as binder-free electrodes for high-performance supercapacitors. The synthesized carbon nanofibers exhibited the features of interconnected 3D networks architecture, large surface area (624 m2 g-1), mesopores-dominated hierarchical porosity, and high graphitization degree. The as-prepared electrode (CN-BC) displayed a maximum specific capacitance of 302 F g-1 at a current density of 0.5 A g-1, high-rate capability and good cyclicity in 6 M KOH electrolyte. This work, together with cost-effective preparation strategy to make high-value utilization of cheap biomass, should have significant implications in the green and mass-producible energy storage.

Polymeric Selectin Ligands Mimicking Complex Carbohydrates: From Selectin Binders to Modifiers of Macrophage Migration.

PubMed

Moog, Kai E; Barz, Matthias; Bartneck, Matthias; Beceren-Braun, Figen; Mohr, Nicole; Wu, Zhuojun; Braun, Lydia; Dernedde, Jens; Liehn, Elisa A; Tacke, Frank; Lammers, Twan; Kunz, Horst; Zentel, Rudolf

2017-01-24

Novel polymeric cell adhesion inhibitors were developed in which the selectin tetrasaccharide sialyl-Lewis X (SLe X ) is multivalently presented on a biocompatible poly(2-hydroxypropyl)methacrylamide (PHPMA) backbone either alone (P1) or in combination with O-sulfated tyramine side chains (P2). For comparison, corresponding polymeric glycomimetics were prepared in which the crucial "single carbohydrate" substructures fucose, galactose, and sialic acid side chains were randomly linked to the PHPMA backbone (P3 or P4 (O-sulfated tyramine)). All polymers have an identical degree of polymerization, as they are derived from the same precursor polymer. Binding assays to selectins, to activated endothelial cells, and to macrophages show that polyHPMA with SLe X is an excellent binder to E-, L-, and P-selectins. However, mimetic P4 can also achieve close to comparable binding affinities in in vitro measurements and surprisingly, it also significantly inhibits the migration of macrophages; this provides new perspectives for the therapy of severe inflammatory diseases. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Aqueous Binder Enhanced High-Performance GeP5 Anode for Lithium-Ion Batteries

PubMed Central

He, Jun; Wei, Yaqing; Hu, Lintong; Li, Huiqiao; Zhai, Tianyou

2018-01-01

GeP5 is a recently reported new anode material for lithium ion batteries (LIBs), it holds a large theoretical capacity about 2300 mAh g−1, and a high rate capability due to its bi-active components and superior conductivity. However, it undergoes a large volume change during its electrochemical alloying and de-alloying with Li, a suitable binder is necessary to stable the electrode integrity for improving cycle performance. In this work, we tried to apply aqueous binders LiPAA and NaCMC to GeP5 anode, and compared the difference in electrochemical performance between them and traditional binder PVDF. As can be seen from the test result, GeP5 can keep stable in both common organic solvents and proton solvents such as water and alcohol solvents, it meets the application requirements of aqueous binders. The electrochemistry results show that the use of LiPAA binder can significantly improve the initial Coulombic efficiency, reversible capacity, and cyclability of GeP5 anode as compared to the electrodes based on NaCMC and PVDF binders. The enhanced electrochemical performance of GeP5 electrode with LiPAA binder can be ascribed to the unique high strength long chain polymer structure of LiPAA, which also provide numerous uniform distributed carboxyl groups to form strong ester groups with active materials and copper current collector. Benefit from that, the GeP5 electrode with LiPAA can also exhibit excellent rate capability, and even at low temperature, it still shows attractive electrochemical performance. PMID:29484292

Wear and corrosion behaviour of tungsten carbide based coatings with different metallic binder

NASA Astrophysics Data System (ADS)

Kamdi, Z.; Apandi, M. N. M.; Ibrahim, M. D.

2017-12-01

Tungsten carbide based coating has been well known as wear and corrosion resistance materials. However, less study is done on comparing the coating with different binder. Thus, in this work the wear and corrosion behaviour of high velocity oxy-fuel (HVOF) coatings, namely (i) tungsten carbide cobalt and (ii) tungsten carbide nickel will be evaluated. Both coatings were characterised using X-ray Diffractometer (XRD) and Scanning Electron Microscope (SEM). The wear behaviour has been examined using the modified grinder machine by weight loss measurement. Two types of abrasive have been used that include 3 g by weight alumina and silica. While for the corrosion behaviour, it is monitored by three electrodes of electrochemical test and immersion test for 30 days in an acidic environment. The electrolyte used was 0.5 M sulphuric acids (H2SO4). It was found that the cobalt binder shows higher wear resistance compares to the nickel binder for both slurry types. The harder alumina compared to silica results in higher wear rate with removal of carbide and binder is about the same rate. For silica abrasive, due to slightly lower hardness compared to the carbide, the wear is dominated by binder removal followed by carbide detachment. For corrosion, the nickel binder shows four times higher wear resistance compared to the cobalt binder as expected due to its natural behaviour. These finding demonstrate that the selection of coating to be used in different application in this case, wear and corrosion shall be chosen carefully to maximize the usage of the coating.

Aqueous Binder Enhanced High-Performance GeP5 Anode for Lithium-Ion Batteries

NASA Astrophysics Data System (ADS)

He, Jun; Wei, Yaqing; Hu, Lintong; Li, Huiqiao; Zhai, Tianyou

2018-02-01

GeP5 is a recently reported new anode material for lithium ion batteries (LIBs), it holds a large theoretical capacity about 2300 mAh g-1, and a high rate capability due to its bi-active components and superior conductivity. However, it undergoes a large volume change during its electrochemical alloying and de-alloying with Li, a suitable binder is necessary to stable the electrode integrity for improving cycle performance. In this work, we tried to apply aqueous binders LiPAA and NaCMC to GeP5 anode, and compared the difference in electrochemical performance between them and traditional binder PVDF. As can be seen from the test result, GeP5 can keep stable in both common organic solvents and proton solvents such as water and alcohol solvents, it meets the application requirements of aqueous binders. The electrochemistry results show that the use of LiPAA binder can significantly improve the initial Coulombic efficiency, reversible capacity, and cyclability of GeP5 anode as compared to the electrodes based on NaCMC and PVDF binders. The enhanced electrochemical performance of GeP5 electrode with LiPAA binder can be ascribed to the unique high strength long chain polymer structure of LiPAA, which also provide numerous uniform distributed carboxyl groups to form strong ester groups with active meterials and copper current collector. Benefit from that, the GeP5 electrode with LiPAA can also exhibit excellent rate capability, and even at low temperature, it still shows attractive electrochemical performance.

Systematic molecular-level design of binders incorporating Meldrum's acid for silicon anodes in lithium rechargeable batteries.

PubMed

Kwon, Tae-woo; Jeong, You Kyeong; Lee, Inhwa; Kim, Taek-Soo; Choi, Jang Wook; Coskun, Ali

2014-12-17

Covalent or Noncovalent? Systematic investigation of polymeric binders incorporating Meldrum's acid reveals most critical binder properties for silicon -anodes in lithium ion batteries, that is self-healing effect facilitated by a series of noncovalent interactions. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

46 CFR 308.6 - Period of interim binders, updating application information and new applications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... information and new applications. 308.6 Section 308.6 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.6 Period of interim binders, updating... interim binders are required to notify the American War Risk Agency annually, by June 30th, of any change...

46 CFR 308.6 - Period of interim binders, updating application information and new applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... information and new applications. 308.6 Section 308.6 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.6 Period of interim binders, updating... interim binders are required to notify the American War Risk Agency annually, by June 30th, of any change...

46 CFR 308.6 - Period of interim binders, updating application information and new applications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... information and new applications. 308.6 Section 308.6 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.6 Period of interim binders, updating... interim binders are required to notify the American War Risk Agency annually, by June 30th, of any change...

46 CFR 308.6 - Period of interim binders, updating application information and new applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... information and new applications. 308.6 Section 308.6 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.6 Period of interim binders, updating... interim binders are required to notify the American War Risk Agency annually, by June 30th, of any change...

7 CFR 1755.200 - RUS standard for splicing copper and fiber optic cables.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Color coded plastic tie wraps shall be placed loosely around each binder group of cables before splicing... conform to the same color designations as the binder ribbons. Twisted wire pigtails shall not be used to identify binder groups due to potential transmission degradation. (ii) The standard insulation color code...

Binders for Energetics - Modelling and Synthesis in Harmony

NASA Astrophysics Data System (ADS)

Dossi, Licia; Cleaver, Doug; Gould, Peter; Dunnett, Jim; Cavaye, Hamish; Ellison, Laurence; Luppi, Federico; Hollands, Ron; Bradley, Mark

The Binders by Design UK programme develop new polymeric materials for energetic applications that can overcome problems related to chemico-physical properties, aging, additives, environmental and performance of energetic compositions. Combined multi-scale modelling and experiment is used for the development of a new modelling tool and with the aim to produce novel materials with great confidence and fast turnaround. New synthesised binders with attractive properties for energetic applications used to provide a high level of confidence in the results of developed models. Molecular dynamics simulations investigate the thermal behaviour and the results directly feed into a Group Interaction Model (GIM). A viscoelastic constitutive model has been developed examining stress development in energetic/binder configurations. GIM data has been used as the basis for developing hydrocode equations of state, which then applied in run-to-detonation type investigations to examine the effect of the shock properties of a binder on the reactivity of a typical Polymer Bonded Explosive in a high-velocity impact type scenario. The Binders by Design UK programme is funded through the Weapons Science and Technology Centre by DSTL.

Influence of solidification accelerators on structure formation of anhydrite-containing binders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anikanova, L., E-mail: alasmit@mail.ru; Volkova, O., E-mail: v.olga.nikitina@gmail.com; Kudyakov, A.

2016-01-15

The article presents results of scientific analysis of chemical additives influence on acid fluoride binder. It was found that the influence of sulfate nature additives on the process of hydration and solidification of the binder is similar to influence of additives on indissoluble anhydrite. Additives with SO{sub 4}{sup 2−} anion NO{sup −} are more efficient. The mentioned additives according to accelerating effect belong to the following succession: K{sub 2}SO{sub 4} > Na{sub 2}SO{sub 4} > FeSO{sub 4} > MgSO{sub 4}. Facilitation of the process of hydration and solidification of the binder, increase in density and durability of the binder (32 MPa)more » is to the greatest extent achieved with the introduction of 2% sodium sulfate additive of the binder’s mass into the composition of the binder along with the ultrasonic treatment of water solution. Directed crystal formation process with healing of porous structure by new growths presented as calcium sulfate dehydrate and hydroglauberite provides positive effect.« less

Performance analysis of flexible DSSC with binder addition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muliani, Lia; Hidayat, Jojo; Anggraini, Putri Nur, E-mail: putri.nur.anggraini@gmail.com

2016-04-19

Flexible DSSC is one of modification of DSSC based on its substrate. Operating at low temperature, flexible DSSC requires a binder to improve particles interconnection. This research was done to compare the morphology and performance of flexible DSSC that was produced with binder-added and binder-free. TiO{sub 2} powder, butanol, and HCl were mixed for preparation of TiO{sub 2} paste. Small amount of titanium isopropoxide as binder was added into the mixture. TiO{sub 2} paste was deposited on ITO-PET plastic substrate with area of 1x1 cm{sup 2} by doctor blade method. Furthermore, SEM, XRD, and BET characterization were done to analyzemore » morphology and surface area of the TiO{sub 2} photoelectrode microstructures. Dyed TiO{sub 2} photoelectrode and platinum counter electrode were assembled and injected by electrolyte. In the last process, flexible DSSCs were illuminated by sun simulator to do J-V measurement. As a result, flexible DSSC containing binder showed higher performance with photoconversion efficiency of 0.31%.« less

Method And Apparatus For Detecting Chemical Binding

DOEpatents

Warner, Benjamin P.; Havrilla, George J.; Miller, Thomasin C.; Wells, Cyndi A.

2005-02-22

The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.

Method and apparatus for detecting chemical binding

DOEpatents

Warner, Benjamin P [Los Alamos, NM; Havrilla, George J [Los Alamos, NM; Miller, Thomasin C [Los Alamos, NM; Wells, Cyndi A [Los Alamos, NM

2007-07-10

The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.

The chemistry of dimethacrylate-styrene networks, and, Development of flame retardant, halogen-free fiber reinforced vinyl ester composites

NASA Astrophysics Data System (ADS)

Rosario, Astrid Christa

One of the major classes of polymer matrix resins under consideration for structural composite applications in the infrastructure and construction industries is vinyl ester resin. Vinyl ester resin is comprised of low molecular weight poly(hydroxyether) oligomers with methacrylate endgroups diluted with styrene monomer. The methacrylate endgroups cure with styrene via free radical copolymerization to yield thermoset networks. The copolymerization behavior of these networks was monitored by Fourier Transform Infrared Spectroscopy (FTIR) at various cure conditions. Reactions of the carbon-carbon double bonds of the methacrylate (943 cm-1) and styrene (910 cm-1 ) were followed independently. Oligomers possessing number average molecular weights of 700 g/mole were studied with systematically increasing levels of styrene. The Mortimer-Tidwell reactivity ratios indicated that at low conversion more styrene was incorporated into the network at lower cure temperatures. The experimental vinyl ester-styrene network compositions deviated significantly from those predicted by the Meyer-Lowry integrated copolymer equation at higher conversion, implying that the reactivity ratios for these networks may change with conversion. The kinetic data were used to provide additional insight into the physical and mechanical properties of these materials. In addition to establishing the copolymerization kinetics of these materials, the development of halogen free fiber reinforced vinyl ester composites exhibiting good flame properties was of interest. Flame retardant vinyl ester resins are used by many industries for applications requiring good thermal resistance. The current flame-retardant technology is dependent on brominated vinyl esters, which generate high levels of smoke and carbon monoxide. A series of halogen free binder systems has been developed and dispersed in the vinyl ester to improve flame retardance. The binder approach enables the vinyl ester resin to maintain its low temperature viscosity so that fabrication of composites via Vacuum Assisted Resin Transfer Molding (VARTM) is possible. The first binder system investigated was a polycaprolactone layered silicate nanocomposite, which was prepared via intercalative polymerization. Transmission Electron Microscopy (TEM) and X-ray Diffraction (XRD) data indicated a mixed morphology of exfoliated and intercalated structures. The mechanical properties and the normalized peak heat release rates were comparable to the neat vinyl ester resin. Alternative binder systems possessing inherent flame retardance were also investigated. A series of binders comprised of novolac, bisphenol A diphosphate, and montmorillonite clay were developed and dispersed into the vinyl ester matrix. Cone calorimetry showed reductions in the peak heat release rate comparable to the brominated resin. Keywords: dimethacrylate; vinyl ester; network; reactivity ratios; nanocomposites; layered silicates; exfoliated; thermoset matrix resin; flame retardant

Rutting resistance of asphalt mixture with cup lumps modified binder

NASA Astrophysics Data System (ADS)

Shaffie, E.; Hanif, W. M. M. Wan; Arshad, A. K.; Hashim, W.

2017-11-01

Rutting is the most common pavement distress in pavement structures which occurs mainly due to several factors such as increasing of traffic volume, climatic conditions and also due to construction design errors. This failure reduced the service life of the pavement, reduced driver safety and increase cost of maintenance. Polymer Modified Binder has been observed for a long time in improving asphalt pavement performance. Research shows that the use of polymer in bituminous mix not only improve the resistance to rutting but also increase the life span of the pavement. This research evaluates the physical properties and rutting performance of dense graded Superpave-designed HMA mix. Two different types of dense graded Superpave HMA mix were developed consists of unmodified binder mix (UMB) and cup lumps rubber (liquid form) modified binder mix (CLMB). Natural rubber polymer modified binder was prepared from addition of 8 percent of cup lumps into binder. Results showed that all the mixes passed the Superpave volumetric properties criteria which indicate that these mixtures were good with respect to durability and flexibility. Furthermore, rutting results from APA rutting test was determined to evaluate the performance of these mixtures. The rutting result of CLMB demonstrates better resistance to rutting than those prepared using UMB mix. Addition of cup lumps rubber in asphalt mixture was found to be significant, where the cup lumps rubber has certainly improves the binder properties and enhanced its rutting resistance due to greater elasticity offered by the cup lumps rubber particles. It shows that the use of cup lumps rubber can significantly reduce the rut depth of asphalt mixture by 41% compared to the minimum rut depth obtained for the UMB mix. Therefore, it can be concluded that the cup lumps rubber is suitable to be used as a modifier to modified binder in order to enhance the properties of the binder and thus improves the performance of asphalt mixes.

Novel Binders and Methods for Agglomeration of Ore

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. K. Kawatra; T. C. Eisele; K. A. Lewandowski

2006-12-31

Many metal extraction operations, such as leaching of copper, leaching of precious metals, and reduction of metal oxides to metal in high-temperature furnaces, require agglomeration of ore to ensure that reactive liquids or gases are evenly distributed throughout the ore being processed. Agglomeration of ore into coarse, porous masses achieves this even distribution of fluids by preventing fine particles from migrating and clogging the spaces and channels between the larger ore particles. Binders are critically necessary to produce agglomerates that will not break down during processing. However, for many important metal extraction processes there are no binders known that willmore » work satisfactorily. Primary examples of this are copper heap leaching, where there are no binders that will work in the acidic environment encountered in this process, and advanced ironmaking processes, where binders must function satisfactorily over an extraordinarily large range of temperatures (from room temperature up to over 1200 C). As a result, operators of many facilities see a large loss of process efficiency due to their inability to take advantage of agglomeration. The large quantities of ore that must be handled in metal extraction processes also means that the binder must be inexpensive and useful at low dosages to be economical. The acid-resistant binders and agglomeration procedures developed in this project will also be adapted for use in improving the energy efficiency and performance of a broad range of mineral agglomeration applications, particularly heap leaching and advanced primary ironmaking. This project has identified several acid-resistant binders and agglomeration procedures that can be used for improving the energy efficiency of heap leaching, by preventing the ''ponding'' and ''channeling'' effects that currently cause reduced recovery and extended leaching cycle times. Methods have also been developed for iron ore processing which are intended to improve the performance of pellet binders, and have directly saved energy by increasing filtration rates of the pelletization feed by as much as 23%.« less

Characterization of domain-peptide interaction interface: a case study on the amphiphysin-1 SH3 domain.

PubMed

Hou, Tingjun; Zhang, Wei; Case, David A; Wang, Wei

2008-02-29

Many important protein-protein interactions are mediated by peptide recognition modular domains, such as the Src homology 3 (SH3), SH2, PDZ, and WW domains. Characterizing the interaction interface of domain-peptide complexes and predicting binding specificity for modular domains are critical for deciphering protein-protein interaction networks. Here, we propose the use of an energetic decomposition analysis to characterize domain-peptide interactions and the molecular interaction energy components (MIECs), including van der Waals, electrostatic, and desolvation energy between residue pairs on the binding interface. We show a proof-of-concept study on the amphiphysin-1 SH3 domain interacting with its peptide ligands. The structures of the human amphiphysin-1 SH3 domain complexed with 884 peptides were first modeled using virtual mutagenesis and optimized by molecular mechanics (MM) minimization. Next, the MIECs between domain and peptide residues were computed using the MM/generalized Born decomposition analysis. We conducted two types of statistical analyses on the MIECs to demonstrate their usefulness for predicting binding affinities of peptides and for classifying peptides into binder and non-binder categories. First, combining partial least squares analysis and genetic algorithm, we fitted linear regression models between the MIECs and the peptide binding affinities on the training data set. These models were then used to predict binding affinities for peptides in the test data set; the predicted values have a correlation coefficient of 0.81 and an unsigned mean error of 0.39 compared with the experimentally measured ones. The partial least squares-genetic algorithm analysis on the MIECs revealed the critical interactions for the binding specificity of the amphiphysin-1 SH3 domain. Next, a support vector machine (SVM) was employed to build classification models based on the MIECs of peptides in the training set. A rigorous training-validation procedure was used to assess the performances of different kernel functions in SVM and different combinations of the MIECs. The best SVM classifier gave satisfactory predictions for the test set, indicated by average prediction accuracy rates of 78% and 91% for the binding and non-binding peptides, respectively. We also showed that the performance of our approach on both binding affinity prediction and binder/non-binder classification was superior to the performances of the conventional MM/Poisson-Boltzmann solvent-accessible surface area and MM/generalized Born solvent-accessible surface area calculations. Our study demonstrates that the analysis of the MIECs between peptides and the SH3 domain can successfully characterize the binding interface, and it provides a framework to derive integrated prediction models for different domain-peptide systems.

Solventless, curable fluid oligomeric systems for high performance microwave, acoustical and mechanical applications

NASA Technical Reports Server (NTRS)

Lefave, G. M.; Stanton, Leo; Foreman, Jim

1994-01-01

While establishing the basis for a 'Technology 2000' product plan several years ago we plugged in the usual factors contributing toward product success: price/performance justifiable; profitable, warranting high quality maintenance, enhancement, and specific property improvement; narrow inventory requirements; and raw material integrable backwards with easily variable properties (molecular weight, functionality, and isomer control). We resolved this by selecting radical functional, low molecular weight polybutadiene liquid polymers. Encouraged by the need for solid rocket binders, several companies embarked on various perceptions of binder performance requirements over four decades ago. Initially dominated by progress of liquid polysulfides, soon a few settled primarily upon polybutadiene based binders. Such an approach in a few instances was exploited quite viably with a series of functional group terminated liquid polybutadienes: hydroxyl, mercaptan, carboxyl, vinyl, and amine. Good results are obtained for oligomers, liquid polymers, and their hybrids. The only significant limits on compounded products has been solvent resistance and oxidative sensitivity, unless sufficient proportion of sulfide or nitrile moiety is incorporated. For convenience, they have been grouped under the trademarks Nylane, Seamax, Oligomax, and Castomax.

Influence of EDTA in poly(acrylic acid) binder for enhancing electrochemical performance and thermal stability of silicon anode

NASA Astrophysics Data System (ADS)

Lee, Sun-Young; Choi, Yunju; Hong, Kyong-Soo; Lee, Jung Kyoo; Kim, Ju-Young; Bae, Jong-Seong; Jeong, Euh Duck

2018-07-01

The crucial roles of ethylenediaminetetraacetic acid (EDTA) in the poly(acrylic acid) (PAA)-binder system were investigated for the high electrochemical performance silicon anode in lithium-ion batteries. The EDTA supports the construction of a mechanically robust network through the formation of sbndCOOH linkage with the SiO2 layer of the Si nanoparticles. The mixture of the PAA/EDTA binder and the conductive agent exhibited an improved elastic modulus and peeling strength. The creation of hydrogen fluoride (HF) was effectively suppressed through the elimination of the H2O. An H2O-phosphorous pentafluoride (PF5) reaction, which is known for its use in the etching of metal oxides including its creation of the solid electrolyte interphase (SEI) layer, generates the HF. A remarkably sound cyclability with a discharge capacity of 2540 mA h g-1 was achieved as a result of the synergistic effect between robust mechanical properties and suppression of the HF creation for the stability of the SEI layer.

Method for forming thin composite solid electrolyte film for lithium batteries

NASA Technical Reports Server (NTRS)

Attia, Alan I. (Inventor); Nagasubramanian, Ganesan (Inventor)

1997-01-01

A composite solid electrolyte film is formed by dissolving a lithium salt such as lithium iodide in a mixture of a first solvent which is a cosolvent for the lithium salt and a binder polymer such as polyethylene oxide and a second solvent which is a solvent for the binder polymer and has poor solubility for the lithium salt. Reinforcing filler such as alumina particles are then added to form a suspension followed by the slow addition of binder polymer. The binder polymer does not agglomerate the alumina particles. The suspension is cast into a uniform film.

Nanosized carbon modifier used to control plastic deformations of asphalt concrete

NASA Astrophysics Data System (ADS)

Vysotskaya, M. A.; Shekhovtsova, S. Yu; Barkovsky, D. V.

2018-03-01

Aspects related to plastic track, the formation of which directly depends on the properties of the binder in the composition of asphalt concrete, are considered in this article. The effect of primary carbon nanomaterials on the quality of polymer and bitumen binder in comparison with the traditional binder including cross-linking agent is evaluated. The influence of binders on the resistance to the track formation of type B asphalt concrete is studied. To quantify the service life of surfacing, a calculation method based on the criteria for the resistance of surfacing material to plastic deformations is used.

Method for forming thin composite solid electrolyte film for lithium batteries

NASA Technical Reports Server (NTRS)

Nagasubramanian, Ganesan (Inventor); Attia, Alan I. (Inventor)

1994-01-01

A composite solid electrolyte film is formed by dissolving a lithium salt such as lithium iodide in a mixture of a first solvent which is a co-solvent for the lithium salt and a binder polymer such as polyethylene oxide and a second solvent which is a solvent for the binder polymer and has poor solubility for the lithium salt. Reinforcing filler such as alumina particles are then added to form a suspension followed by the slow addition of binder polymer. The binder polymer does not agglomerate the alumina particles. The suspension is cast into a uniform film.

40 CFR 1065.1107 - Sample media and sample system preparation; sample system assembly.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) For capturing PM, we recommend using pure quartz filters with no binder. Select the filter diameter to minimize filter change intervals, accounting for the expected PM emission rate, sample flow rate, and... filter without replacing the sorbent or otherwise disassembling the batch sampler. In those cases...

The School Personnel Management System. Manual 1--Tools. Manual 2--Models. Manual 3--Results.

ERIC Educational Resources Information Center

National School Boards Association, Washington, DC.

The School Personnel Management System offers a correlated set of job descriptions, evaluative instruments, policies, tools, forms, and publications intended to aid local school officials in enhancing their personnel management programs. The materials are contained in two looseleaf binders entitled "Manual 1--Tools," and "Manual…

Paraffin wax removal from metal injection moulded cocrmo alloy compact by solvent debinding process

NASA Astrophysics Data System (ADS)

Dandang, N. A. N.; Harun, W. S. W.; Khalil, N. Z.; Ahmad, A. H.; Romlay, F. R. M.; Johari, N. A.

2017-10-01

One of the most crucial and time consuming phase in metal injection moulding (MIM) process is “debinding”. These days, in metal injection moulding process, they had recounted that first debinding practice was depend on thermal binder degradation, which demanding more than 200 hours for complete removal of binder. Fortunately, these days world had introduced multi-stage debinding techniques to simplified the debinding time process. This research study variables for solvent debinding which are temperature and soaking time for samples made by MIM CoCrMo powder. Since wax as the key principal in the binder origination, paraffin wax will be removed together with stearic acid from the green bodies. Then, debinding process is conducted at 50, 60 and 70°C for 30-240 minutes. It is carried out in n-heptane solution. Percentage weight loss of the binder were measured. Lastly, scanning electron microscope (SEM) analysis and visual inspection were observed for the surface of brown compact. From the results, samples debound at 70°C exhibited a significant amount of binder loss; nevertheless, sample collapse, brittle surface and cracks were detected. But, at 60°C temperature and time of 4 hours proven finest results as it shows sufficient binder loss, nonappearance of surface cracks and easy to handle. Overall, binder loss is directly related to solvent debinding temperature and time.

Evolution of the microstructure of unmodified and polymer modified asphalt binders with aging in an accelerated weathering tester.

PubMed

Menapace, Ilaria; Masad, Eyad

2016-09-01

This paper presents findings on the evolution of the surface microstructure of two asphalt binders, one unmodified and one polymer modified, directly exposed to aging agents with increasing durations. The aging is performed using an accelerated weathering tester, where ultraviolet radiation, oxygen and an increased temperature are applied to the asphalt binder surface. Ultraviolet and dark cycles, which simulated the succession of day and night, alternated during the aging process, and also the temperature varied, which corresponded to typical summer day and night temperatures registered in the state of Qatar. Direct aging of an exposed binder surface is more effective in showing microstructural modifications than previously applied protocols, which involved the heat treatment of binders previously aged with standardized methods. With the new protocol, any molecular rearrangements in the binder surface after aging induced by the heat treatment is prevented. Optical photos show the rippling and degradation of the binder surface due to aging. Microstructure images obtained by means of atomic force microscopy show gradual alteration of the surface due to aging. The original relatively flat microstructure was substituted with a profoundly different microstructure, which significantly protrudes from the surface, and is characterized by various shapes, such as rods, round structures and finally 'flower' or 'leaf' structures. © 2016 The Authors Journal of Microscopy © 2016 Royal Microscopical Society.

Effect of treatment temperature on the microstructure of asphalt binders: insights on the development of dispersed domains.

PubMed

Menapace, I; Masad, E; Bhasin, A

2016-04-01

This paper offers important insights on the development of the microstructure in asphalt binders as a function of the treatment temperature. Different treatment temperatures are useful to understand how dispersed domains form when different driving energies for the mobility of molecular species are provided. Small and flat dispersed domains, with average diameter between 0.02 and 0.70 μm, were detected on the surface of two binders at room temperature, and these domains were observed to grow with an increase in treatment temperature (up to over 2 μm). Bee-like structures started to appear after treatment at or above 100°C. Moreover, the effect of the binder thickness on its microstructure at room temperature and at higher treatment temperatures was investigated and is discussed in this paper. At room temperature, the average size of the dispersed domains increased as the binder thickness decreased. A hypothesis that conciliates current theories on the origin and development of dispersed domains is proposed. Small dispersed domains (average diameter around 0.02 μm) are present in the bulk of the binder, whereas larger domains and bee-like structures develop on the surface, following heat treatment or mechanical disturbance that reduces the film thickness. Molecular mobility and association are the key factors in the development of binder microstructure. © 2015 The Authors Journal of Microscopy © 2015 Royal Microscopical Society.

Anisotropic fibrous thermal insulator of relatively thick cross section and method for making same

DOEpatents

Reynolds, Carl D.; Ardary, Zane L.

1979-01-01

The present invention is directed to an anisotropic thermal insulator formed of carbon-bonded organic or inorganic fibers and having a thickness or cross section greater than about 3 centimeters. Delaminations and deleterious internal stresses generated during binder curing and carbonizing operations employed in the fabrication of thick fibrous insulation of thicknesses greater than 3 centimeters are essentially obviated by the method of the present invention. A slurry of fibers, thermosetting resin binder and water is vacuum molded into the selected insulator configuration with the total thickness of the molded slurry being less than about 3 centimeters, the binder is thermoset to join the fibers together at their nexaes, and then the binder is carbonized to form the carbon bond. A second slurry of the fibers, binder and water is then applied over the carbonized body with the vacuum molding, binder thermosetting and carbonizing steps being repeated to form a layered insulator with the binder providing a carbon bond between the layers. The molding, thermosetting and carbonizing steps may be repeated with additional slurries until the thermal insulator is of the desired final thickness. An additional feature of the present invention is provided by incorporating opacifying materials in any of the desired layers so as to provide different insulating properties at various temperatures. Concentration and/or type of additive can be varied from layer-to-layer.

The Effect of Abdominal Support on Functional Outcomes in Patients Following Major Abdominal Surgery: A Randomized Controlled Trial

PubMed Central

Cheifetz, Oren; Overend, Tom J.; Crowe, Jean

2010-01-01

ABSTRACT Purpose: Immobility and pain are modifiable risk factors for development of venous thromboembolism and pulmonary morbidity after major abdominal surgery (MAS). The purpose of this study was to investigate the effect of abdominal incision support with an elasticized abdominal binder on postoperative walk performance (mobility), perceived distress, pain, and pulmonary function in patients following MAS. Methods: Seventy-five patients scheduled to undergo MAS via laparotomy were randomized to experimental (binder) or control (no binder) groups. Sixty (33 male, 27 female; mean age 58±14.9 years) completed the study. Preoperative measurements of 6-minute walk test (6MWT) distance, perceived distress, pain, and pulmonary function were repeated 1, 3, and 5 days after surgery. Results: Surgery was associated with marked postoperative reductions (p<0.001) in walk distance (∼75–78%, day 3) and forced vital capacity (35%, all days) for both groups. Improved 6MWT distance by day 5 was greater (p<0.05) for patients wearing a binder (80%) than for the control group (48%). Pain and symptom-associated distress remained unchanged following surgery with binder usage, increasing significantly (p<0.05) only in the no binder group. Conclusion: Elasticized abdominal binders provide a non-invasive intervention for enhancing recovery of walk performance, controlling pain and distress, and improving patients' experience following MAS. PMID:21629603

Environment-friendly cathodes using biopolymer chitosan with enhanced electrochemical behavior for use in lithium ion batteries.

PubMed

Prasanna, K; Subburaj, T; Jo, Yong Nam; Lee, Won Jong; Lee, Chang Woo

2015-04-22

The biopolymer chitosan has been investigated as a potential binder for the fabrication of LiFePO4 cathode electrodes in lithium ion batteries. Chitosan is compared to the conventional binder, polyvinylidene fluoride (PVDF). Dispersion of the active material, LiFePO4, and conductive agent, Super P carbon black, is tested using a viscosity analysis. The enhanced structural and morphological properties of chitosan are compared to the PVDF binder using X-ray diffraction analysis (XRD) and field emission scanning electron microscopy (FE-SEM). Using an electrochemical impedance spectroscopy (EIS) analysis, the LiFePO4 electrode with the chitosan binder is observed to have a high ionic conductivity and a smaller increase in charge transfer resistance based on time compared to the LiFePO4 electrode with the PVDF binder. The electrode with the chitosan binder also attains a higher discharge capacity of 159.4 mAh g(-1) with an excellent capacity retention ratio of 98.38% compared to the electrode with the PVDF binder, which had a discharge capacity of 127.9 mAh g(-1) and a capacity retention ratio of 85.13%. Further, the cycling behavior of the chitosan-based electrode is supported by scrutinizing its charge-discharge behavior at specified intervals and by a plot of dQ/dV.

Conductivity degradation of polyvinylidene fluoride composite binder during cycling: Measurements and simulations for lithium-ion batteries

DOE PAGES

Grillet, Anne M.; Humplik, Thomas; Stirrup, Emily K.; ...

2016-07-02

The polymer-composite binder used in lithium-ion battery electrodes must both hold the electrodes together and augment their electrical conductivity while subjected to mechanical stresses caused by active material volume changes due to lithiation and delithiation. We have discovered that cyclic mechanical stresses cause significant degradation in the binder electrical conductivity. After just 160 mechanical cycles, the conductivity of polyvinylidene fluoride (PVDF):carbon black binder dropped between 45–75%. This degradation in binder conductivity has been shown to be quite general, occurring over a range of carbon black concentrations, with and without absorbed electrolyte solvent and for different polymer manufacturers. Mechanical cycling ofmore » lithium cobalt oxide (LiCoO2) cathodes caused a similar degradation, reducing the effective electrical conductivity by 30–40%. Mesoscale simulations on a reconstructed experimental cathode geometry predicted the binder conductivity degradation will have a proportional impact on cathode electrical conductivity, in qualitative agreement with the experimental measurements. Lastly, ohmic resistance measurements were made on complete batteries. Direct comparisons between electrochemical cycling and mechanical cycling show consistent trends in the conductivity decline. This evidence supports a new mechanism for performance decline of rechargeable lithium-ion batteries during operation – electrochemically-induced mechanical stresses that degrade binder conductivity, increasing the internal resistance of the battery with cycling.« less

Char binder for fluidized beds

DOEpatents

Borio, Richard W.; Accortt, Joseph I.

1981-01-01

An arrangement that utilizes agglomerating coal as a binder to bond coal fines and recycled char into an agglomerate mass that will have suitable retention time when introduced into a fluidized bed 14 for combustion. The simultaneous use of coal for a primary fuel and as a binder effects significant savings in the elimination of non-essential materials and processing steps.

Guide for preparing active solar heating systems operation and maintenance manuals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-01-01

This book presents a systematic and standardized approach to the preparation of operation and maintenance manuals for active solar heating systems. Provides an industry consensus of the best operating and maintenance procedures for large commercial-scale solar service water and space heating systems. A sample O M manual is included. 3-ring binder included.

Five year magnetic tape for unattended satellite tape recorders

NASA Technical Reports Server (NTRS)

Benn, G. S. L.; Gutfreund, K.

1972-01-01

The development and fabrication of a quantity of long life magnetic tape with properties selected specifically for unattended operation in spacecraft tape recorders was studied. A detailed analytical consideration of various binder systems was undertaken. This included the chemical aspects of the binders, cohesion and adhesion effects, stability and the mechanical and physical properties. The ability to form free films of these polymers and their combination with various oxide loadings and other additives allowed a rapid selection of four polymer candidates for a five year magnetic tape. Samples were evaluated under actual running conditions which included physical, magnetic, and extensive life testing. These sample tapes withstood 50,000 bidirectional tape passes under fairly harsh operating conditions.

Early-age hydration and volume change of calcium sulfoaluminate cement-based binders

NASA Astrophysics Data System (ADS)

Chaunsali, Piyush

Shrinkage cracking is a predominant deterioration mechanism in structures with high surface-to-volume ratio. One way to allay shrinkage-induced stresses is to use calcium sulfoaluminate (CSA) cement whose early-age expansion in restrained condition induces compressive stress that can be utilized to counter the tensile stresses due to shrinkage. In addition to enhancing the resistance against shrinkage cracking, CSA cement also has lower carbon footprint than that of Portland cement. This dissertation aims at improving the understanding of early-age volume change of CSA cement-based binders. For the first time, interaction between mineral admixtures (Class F fly ash, Class C fly ash, and silica fume) and OPC-CSA binder was studied. Various physico-chemical factors such as the hydration of ye'elimite (main component in CSA cement), amount of ettringite (the main phase responsible for expansion in CSA cement), supersaturation with respect to ettringite in cement pore solution, total pore volume, and material stiffness were monitored to examine early-age expansion characteristics. This research validated the crystallization stress theory by showing the presence of higher supersaturation level of ettringite, and therefore, higher crystallization stress in CSA cement-based binders. Supersaturation with respect to ettringite was found to increase with CSA dosage and external supply of gypsum. Mineral admixtures (MA) altered the expansion characteristics in OPC-CSA-MA binders with fixed CSA cement. This study reports that fly ash (FA) behaves differently depending on its phase composition. The Class C FA-based binder (OPC-CSA-CFA) ceased expanding beyond two days unlike other OPC-CSA-MA binders. Three factors were found to govern expansion of CSA cement-based binders: 1) volume fraction of ettringite in given pore volume, 2) saturation level of ettringite, and 3) dynamic modulus. Various models were utilized to estimate the macroscopic tensile stress in CSA cement-based binders without taking into account the viscoelastic effects. For the first time, model based on poromechanics was used to calculate the macroscopic tensile stress that develops in CSA cement-based binders due to crystallization of ettringite. The models enabled a reasonable prediction of tensile stress due to crystallization of ettringite including the failure of an OPC-CSA binder which had high CSA cement content. Elastic strain based on crystallization stress was calculated and compared with the observed strain. A mismatch between observed and calculated elastic strain indicated the presence of early-age creep. Lastly, the application of CSA cement in concretes is discussed to link the paste and concrete behavior.

Stabilisation/solidification of synthetic petroleum drill cuttings.

PubMed

Al-Ansary, Marwa S; Al-Tabbaa, Abir

2007-03-15

This paper presents the results of an experimental investigation into the use of stabilisation/solidification (S/S) to treat synthetic drill cuttings as a pre-treatment to landfilling or for potential re-use as construction products. Two synthetic mixes were used based on average concentrations of specific contaminates present in typical drill cuttings from the North Sea and the Red Sea areas. The two synthetic drill cuttings contained similar chloride content of 2.03% and 2.13% by weight but different hydrocarbon content of 4.20% and 10.95% by weight, respectively; hence the mixes were denoted as low and high oil content mixes, respectively. A number of conventional S/S binders were tested including Portland cement (PC), lime and blast-furnace slag (BFS), in addition to novel binders such as microsilica and magnesium oxide cement. Physical, chemical and microstructural analyses were used to compare the relative performance of the different binder mixes. The unconfined compressive strength (UCS) values were observed to cover a wide range depending on the binder used. Despite the significant difference in the hydrocarbon content in the two synthetic cuttings, the measured UCS values of the mixes with the same binder type and content were similar. The leachability results showed the reduction of the synthetic drill cuttings to a stable non-reactive hazardous waste, compliant with the UK acceptance criteria for non-hazardous landfills: (a) by most of the binders for chloride concentrations, and (b) by the 20% BFS-PC and 30% PC binders for the low oil content mix. The 30% BFS-PC binder successfully reduced the leached oil concentration of the low oil content mix to inert levels. Finally, the microstructural analysis offered valuable information on the morphology and general behaviour of the mixes that were not depicted by the other tests.

DNA-Encoded Dynamic Combinatorial Chemical Libraries.

PubMed

Reddavide, Francesco V; Lin, Weilin; Lehnert, Sarah; Zhang, Yixin

2015-06-26

Dynamic combinatorial chemistry (DCC) explores the thermodynamic equilibrium of reversible reactions. Its application in the discovery of protein binders is largely limited by difficulties in the analysis of complex reaction mixtures. DNA-encoded chemical library (DECL) technology allows the selection of binders from a mixture of up to billions of different compounds; however, experimental results often show low a signal-to-noise ratio and poor correlation between enrichment factor and binding affinity. Herein we describe the design and application of DNA-encoded dynamic combinatorial chemical libraries (EDCCLs). Our experiments have shown that the EDCCL approach can be used not only to convert monovalent binders into high-affinity bivalent binders, but also to cause remarkably enhanced enrichment of potent bivalent binders by driving their in situ synthesis. We also demonstrate the application of EDCCLs in DNA-templated chemical reactions. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Criteria for asphalt-rubber concrete in civil airport pavements: Mixture design

NASA Astrophysics Data System (ADS)

Roberts, F. L.; Lytton, R. L.; Hoyt, D.

1986-07-01

A mixture design procedure is developed to allow the use of asphalt-rubber binders in concrete for flexible airport pavement. The asphalt-rubber is produced by reacting asphalt with ground, scrap tire rubber to produce the binder for the asphalt-rubber concrete. Procedures for laboratory preparation of alsphalt-rubber binders using an equipment setup that was found by researchers to produce laboratory binders with similar properties to field processes are included. The rubber-asphalt concrete mixture design procedure includes adjustments to the aggregate gradation to permit space for the rubber particles in the asphalt-rubber binder as well as suggested mixing and compaction temperatures, and compaction efforts. While the procedure was used in the laboratory to successfully produce asphalt-rubber concrete mixtures, it should be evaluated in the field to ensure that consistent results can be achieved in a production environment.

Microarray Detection of Duplex and Triplex DNA Binders with DNA-Modified Gold Nanoparticles

PubMed Central

Lytton-Jean, Abigail K. R.; Han, Min Su; Mirkin, Chad A.

2008-01-01

We have designed a chip-based assay, using microarray technology, for determining the relative binding affinities of duplex and triplex DNA binders. This assay combines the high discrimination capabilities afforded by DNA-modified Au nanoparticles with the high-throughput capabilities of DNA microarrays. The detection and screening of duplex DNA binders are important because these molecules, in many cases, are potential anticancer agents as well as toxins. Triplex DNA binders are also promising drug candidates. These molecules, in conjunction with triplex forming oligonucleotides, could potentially be used to achieve control of gene expression by interfering with transcription factors that bind to DNA. Therefore, the ability to screen for these molecules in a high-throughput fashion could dramatically improve the drug screening process. The assay reported here provides excellent discrimination between strong, intermediate, and weak duplex and triplex DNA binders in a high-throughput fashion. PMID:17614366

Process Development of Porcelain Ceramic Material with Binder Jetting Process for Dental Applications

NASA Astrophysics Data System (ADS)

Miyanaji, Hadi; Zhang, Shanshan; Lassell, Austin; Zandinejad, Amirali; Yang, Li

2016-03-01

Custom ceramic structures possess significant potentials in many applications such as dentistry and aerospace where extreme environments are present. Specifically, highly customized geometries with adequate performance are needed for various dental prostheses applications. This paper demonstrates the development of process and post-process parameters for a dental porcelain ceramic material using binder jetting additive manufacturing (AM). Various process parameters such as binder amount, drying power level, drying time and powder spread speed were studied experimentally for their effect on geometrical and mechanical characteristics of green parts. In addition, the effects of sintering and printing parameters on the qualities of the densified ceramic structures were also investigated experimentally. The results provide insights into the process-property relationships for the binder jetting AM process, and some of the challenges of the process that need to be further characterized for the successful adoption of the binder jetting technology in high quality ceramic fabrications are discussed.

Testing of Binders Toxicological Effects

NASA Astrophysics Data System (ADS)

Strokova, V.; Nelyubova, V.; Rykunova, M.

2017-11-01

The article presents the results of a study of the toxicological effect of binders with different compositions on the vital activity of plant and animal test-objects. The analysis of the effect on plant cultures was made on the basis of the phytotesting data. The study of the effect of binders on objects of animal origin was carried out using the method of short-term testing. Based on the data obtained, binders are ranked according to the degree of increase in the toxic effect: Gypsum → Portland cement → Slag Portland cement. Regardless of the test-object type, the influence of binders is due to the release of various elements (calcium ions or heavy metals) into the solution. In case of plant cultures, the saturation of the solution with elements has a positive effect (there is no inhibitory effect), and in case of animal specimens - an increase in the toxic effect.

Studies of organic paint binders by NMR spectroscopy

NASA Astrophysics Data System (ADS)

Spyros, A.; Anglos, D.

2006-06-01

Nuclear magnetic resonance spectroscopy is applied to the study of aged binding media used in paintings, namely linseed oil, egg tempera and an acrylic medium. High resolution 1D and 2D NMR experiments establish the state of hydrolysis and oxidation of the linseed and egg tempera binders after five years of aging, by determining several markers sensitive to the hydrolytic and oxidative processes of the binder lipid fraction. The composition of the acrylic binder co-polymer is determined by 2D NMR spectroscopy, while the identification of a surfactant, poly(ethylene glycol), found in greater amounts in aged acrylic medium, is reported. The non-destructive nature of the proposed analytical NMR methodology, and minimization of the amount of binder material needed through the use of sophisticated cryoprobes and hyphenated LC-NMR techniques, make NMR attractive for the arts analyst, in view of its rapid nature and experimental simplicity.

In situ multi-length scale approach to understand the mechanics of soft and rigid binder in composite lithium ion battery electrodes

NASA Astrophysics Data System (ADS)

Jäckel, Nicolas; Dargel, Vadim; Shpigel, Netanel; Sigalov, Sergey; Levi, Mikhael D.; Daikhin, Leonid; Aurbach, Doron; Presser, Volker

2017-12-01

Intercalation-induced dimensional changes of composite battery electrodes containing either a stiff or a soft polymeric binder is one of the many factors determining the cycling performance and ageing. Herein, we report dimensional changes in bulk composite electrodes by in situ electrochemical dilatometry (eD) combined with electrochemical quartz-crystal microbalance with dissipation monitoring (EQCM-D). The latter tracks the mechanical properties on the level of the electrode particle size. Lithium iron phosphate (LiFePO4, LFP) electrodes with a stiff binder (PVdF) and a soft binder (NaCMC) were investigated by cycling in lithium sulfate (Li2SO4) aqueous solution. The electrochemical and mechanical electrode performances depend on the electrode cycling history. Based on combined eD and EQCM-D measurements we provide evidence which properties are preferred for a binder used for a composite Li-ion battery electrode.

Graphene nanocomposites for electrochemical cell electrodes

DOEpatents

Zhamu, Aruna; Jang, Bor Z.; Shi, Jinjun

2015-11-19

A composite composition for electrochemical cell electrode applications, the composition comprising multiple solid particles, wherein (a) a solid particle is composed of graphene platelets dispersed in or bonded by a first matrix or binder material, wherein the graphene platelets are not obtained from graphitization of the first binder or matrix material; (b) the graphene platelets have a length or width in the range of 10 nm to 10 .mu.m; (c) the multiple solid particles are bonded by a second binder material; and (d) the first or second binder material is selected from a polymer, polymeric carbon, amorphous carbon, metal, glass, ceramic, oxide, organic material, or a combination thereof. For a lithium ion battery anode application, the first binder or matrix material is preferably amorphous carbon or polymeric carbon. Such a composite composition provides a high anode capacity and good cycling response. For a supercapacitor electrode application, the solid particles preferably have meso-scale pores therein to accommodate electrolyte.

Epoxidized Natural Rubber/Chitosan Network Binder for Silicon Anode in Lithium-Ion Battery.

PubMed

Lee, Sang Ha; Lee, Jeong Hun; Nam, Dong Ho; Cho, Misuk; Kim, Jaehoon; Chanthad, Chalathorn; Lee, Youngkwan

2018-05-16

Polymeric binder is extremely important for Si-based anode in lithium-ion batteries due to large volume variation during charging/discharging process. Here, natural rubber-incorporated chitosan networks were designed as a binder material to obtain both adhesion and elasticity. Chitosan could strongly anchor Si particles through hydrogen bonding, while the natural rubber could stretch reversibly during the volume variation of Si particles, resulting in high cyclic performance. The prepared electrode exhibited the specific capacities of 1350 mAh/g after 1600 cycles at the current density of 8 A/g and 2310 mAh/g after 500 cycles at the current density of 1 A/g. Furthermore, the cycle test with limiting lithiation capacity was conducted to study the optimal binder properties at varying degree of the volume expansion of silicon, and it was found that the elastic property of binder material was strongly required when the large volume expansion of Si occurred.

Directly Grown Nanostructured Electrodes for High Volumetric Energy Density Binder-Free Hybrid Supercapacitors: A Case Study of CNTs//Li4Ti5O12

NASA Astrophysics Data System (ADS)

Zuo, Wenhua; Wang, Chong; Li, Yuanyuan; Liu, Jinping

2015-01-01

Hybrid supercapacitor (HSC), which typically consists of a Li-ion battery electrode and an electric double-layer supercapacitor electrode, has been extensively investigated for large-scale applications such as hybrid electric vehicles, etc. Its application potential for thin-film downsized energy storage systems that always prefer high volumetric energy/power densities, however, has not yet been explored. Herein, as a case study, we develop an entirely binder-free HSC by using multiwalled carbon nanotube (MWCNT) network film as the cathode and Li4Ti5O12 (LTO) nanowire array as the anode and study the volumetric energy storage capability. Both the electrode materials are grown directly on carbon cloth current collector, ensuring robust mechanical/electrical contacts and flexibility. Our 3 V HSC device exhibits maximum volumetric energy density of ~4.38 mWh cm-3, much superior to those of previous supercapacitors based on thin-film electrodes fabricated directly on carbon cloth and even comparable to the commercial thin-film lithium battery. It also has volumetric power densities comparable to that of the commercial 5.5 V/100 mF supercapacitor (can be operated within 3 s) and has excellent cycling stability (~92% retention after 3000 cycles). The concept of utilizing binder-free electrodes to construct HSC for thin-film energy storage may be readily extended to other HSC electrode systems.

Self-assembly kinetics of DNA functionalised liposomes

NASA Astrophysics Data System (ADS)

Mognetti, B. M.; Bachmann, S. J.; Kotar, J.; Parolini, L.; Petitzon, M.; Cicuta, P.; di Michele, L.

DNA has been largely used to program state-dependent interactions between functionalised Brownian units resulting in responsive systems featuring complex phase behaviours. In this talk I will show how DNA can also be used to control aggregation kinetics in systems of liposomes functionalised by three types of linkers that can simultaneously bind. In doing so, I will present a general coarse-graining strategy that allows calculating the adhesion free energy between pairs of compliant units functionalised by mobile binders. I will highlight the important role played by bilayer deformability and will calculate the free energy contribution due to the presence of complexes made by more than two binders. Finally we will demonstrate the importance of explicitly accounting for the kinetics underlying ligand-receptor reactions when studying large-scale self-assembly. We acknowledge support from ULB, the Oppenheimer Fund, and the EPSRC Programme Grant CAPITALS No. EP/J017566/1.

Developing a Livebinder as Teaching Resource in Family & Consumer Sciences

ERIC Educational Resources Information Center

Miller, Cynthia L.

2015-01-01

The primary purpose of this paper is to explain how a digital tool, "LiveBinder," can be used for organizing online content and learning. The article explains why this digital tool should be utilized as a teaching resource and describes common uses. It also addresses how LiveBinders can be organized using shelves. A model LiveBinder of…

Ductile Binder Phase For Use With Almgb14 And Other Hard Ceramic Materials

DOEpatents

Cook, Bruce A.; Russell, Alan; Harringa, Joel

2005-07-26

This invention relates to a ductile binder phase for use with AlMgB14 and other hard materials. The ductile binder phase, a cobalt-manganese alloy, is used in appropriate quantities to tailor good hardness and reasonable fracture toughness for hard materials so they can be used suitably in industrial machining and grinding applications.

Polyolefin backbone substitution in binders for low temperature powder injection moulding feedstocks.

PubMed

Hausnerova, Berenika; Kuritka, Ivo; Bleyan, Davit

2014-02-27

This paper reports the substitution of polyolefin backbone binder components with low melting temperature carnauba wax for powder injection moulding applications. The effect of various binder compositions of Al₂O₃ feedstock on thermal degradation parameters is investigated by thermogravimetric analysis. Within the experimental framework 29 original feedstock compositions were prepared and the superiority of carnauba wax over the polyethylene binder backbone was demonstrated in compositions containing polyethylene glycol as the initial opening agent and governing the proper mechanism of the degradation process. Moreover, the replacement of synthetic polymer by the natural wax contributes to an increase of environmental sustainability of modern industrial technologies.

Matrices of radiation-protective composites using bismuth oxide

NASA Astrophysics Data System (ADS)

Yashkina, S. Yu; Doroganov, V. A.; Trepalina, Yu N.; Loktionov, V. A.; Evtushenko, E. I.

2018-03-01

The article presents the results of investigations of radiation-protective composites with two types of matrices based on chamotte and aluminous binders. The synthesis of binders was carried out according to the principles of the production of ceramic concrete based on the artificial ceramic binders (ACB). Bismuth oxide was selected as filler. Basic physical and mechanical, as well as radiation-protective characteristics, of composites with different ratios of ACB and Bi2O3 were shown. It was found out that binder of high-alumina chamotte can be used as an optimal matrix base. Composites on its basis have higher structural and radiation-protective properties.

Combinatorially Screened Peptide as Targeted Covalent Binder: Alteration of Bait-Conjugated Peptide to Reactive Modifier.

PubMed

Uematsu, Shuta; Tabuchi, Yudai; Ito, Yuji; Taki, Masumi

2018-06-01

A peptide-type covalent binder for a target protein was obtained by combinatorial screening of fluoroprobe-conjugated peptide libraries on bacteriophage T7. The solvatochromic fluoroprobe works as a bait during the affinity selection process of phage display. To obtain the targeted covalent binder, the bait in the selected consensus peptide was altered into a reactive warhead possessing a sulfonyl fluoride. The reaction efficiency and site/position specificity of the covalent conjugation between the binder and the target protein were evaluated by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and rationalized by a protein-ligand docking simulation.

OncoBinder facilitates interpretation of proteomic interaction data by capturing coactivation pairs in cancer.

PubMed

Van Coillie, Samya; Liang, Lunxi; Zhang, Yao; Wang, Huanbin; Fang, Jing-Yuan; Xu, Jie

2016-04-05

High-throughput methods such as co-immunoprecipitationmass spectrometry (coIP-MS) and yeast 2 hybridization (Y2H) have suggested a broad range of unannotated protein-protein interactions (PPIs), and interpretation of these PPIs remains a challenging task. The advancements in cancer genomic researches allow for the inference of "coactivation pairs" in cancer, which may facilitate the identification of PPIs involved in cancer. Here we present OncoBinder as a tool for the assessment of proteomic interaction data based on the functional synergy of oncoproteins in cancer. This decision tree-based method combines gene mutation, copy number and mRNA expression information to infer the functional status of protein-coding genes. We applied OncoBinder to evaluate the potential binders of EGFR and ERK2 proteins based on the gastric cancer dataset of The Cancer Genome Atlas (TCGA). As a result, OncoBinder identified high confidence interactions (annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) or validated by low-throughput assays) more efficiently than co-expression based method. Taken together, our results suggest that evaluation of gene functional synergy in cancer may facilitate the interpretation of proteomic interaction data. The OncoBinder toolbox for Matlab is freely accessible online.

Effect of solvents on the electrochemical properties of binder-free sulfur cathode films in lithium–sulfur batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryu, Ho-Suk; Kim, Byeong-Wook; Park, Jin-Woo

Highlights: • The binder-free sulfur electrode with high sulfur contents of 75 wt.% was fabricated. • The binder-free sulfur electrode using NMP solvents showed 784 mAh g{sup −1} after 40 cycles. • The solvent affect the electrochemical properties of binder-free sulfur electrode films. - Abstract: The effects of solvents on the preparation of sulfur cathodes were investigated by fabricating binder-free sulfur electrode films using three different solvents: 1-methyl-2-pyrrolidinone (NMP), acetonitrile, and deionized water. These solvents are commonly employed to dissolve binders used to prepare sulfur cathodes for lithium–sulfur batteries. The sulfur electrode fabricated with NMP had a higher discharge capacitymore » and longer cycle life than the ones fabricated with acetonitrile and deionized water. Better adhesion between the current collector and the sulfur electrode accounted for the improved capacity and cycle life of the battery. In addition, the stability of the electrode in the electrolyte was a result of the solubility of sulfur in the solvent. We thus concluded that the solvents used in the fabrication of sulfur electrodes had a positive influence on the electrochemical properties of Li–S batteries.« less

Use of Adhesion Promoters in Asphalt Mixtures

NASA Astrophysics Data System (ADS)

Cihlářová, Denisa; Fencl, Ivan; Cápayová, Silvia; Pospíšil, Petr

2018-03-01

The purpose of asphalt binder as a significant binder in road constructions is to permanently bind aggregates of different compositions and grain sizes. The asphalt binder itself does not have suitable adhesiveness, so after a period of time, bare grains can appear. This results in a gradual separation of the grains from an asphalt layer and the presence of potholes in a pavement. Adhesion promoters or adhesive agents are important and proven promoters in practice. They are substances mainly based on the fatty acids of polyamides which should increase the reliability of the asphalt's binder adhesion to the aggregates, thus increasing the lifetime period of the asphalt mixture as well as its resistance to mechanical strain. The amount of a promoter or agent added to the asphalt mixture is negligible and constitutes about 0.3% of the asphalt's binder weight. Nevertheless, even this quantity significantly increases the adhesive qualities of an asphalt binder. The article was created in cooperatation with the Slovak University of Technology, in Bratislava, Slovakia, and focuses on proving the new AD2 adhesive additive and comparing it with the Addibit and Wetfix BE promoters used on aggregates from the Skuteč - Litická and Bystřec quarries.

Poly(isobutylene-alt-maleic anhydride) binders containing lithium for high-performance Li-ion batteries

NASA Astrophysics Data System (ADS)

Ku, Jun-Hwan; Hwang, Seung-Sik; Ham, Dong-Jin; Song, Min-Sang; Shon, Jeong-Kuk; Ji, Sang-Min; Choi, Jae-Man; Doo, Seok-Gwang

2015-08-01

Anode materials including graphite are known to be thermodynamically unstable toward organic solvents and salts and become covered by a passivating film (Solid electrolyte interphase, SEI) which retards the kinetics because of the high electronic resistivity. To achieve high performance in lithium ion batteries (LIBs), the SEIs are required to be mechanically stable during repeated cycling and possess highly ion-conductive. In this work, we have investigated an artificial pre-SEI on graphite electrode using a polymer binder containing lithium (i.e., a Li-copolymer of isobutylene and maleic anhydride, Li-PIMA) and its effect on the anode performances. During charging, the polymer binder with the functional group (-COOLi) acts as a SEI component, reducing the electrolyte decomposition and providing a stable passivating layer for the favorable penetration of lithium ions. Hence, by using the binder containing lithium, we have been able to obtain the first Coulombic efficiency of 84.2% (compared to 77.2% obtained using polyvinylidene fluoride as the binder) and a capacity retention of 99% after 100 cycles. The results of our study demonstrate that binder containing lithium we have used is a favorable candidate for the development of high-performance LIBs.

SNAP dendrimers: multivalent protein display on dendrimer-like DNA for directed evolution.

PubMed

Kaltenbach, Miriam; Stein, Viktor; Hollfelder, Florian

2011-09-19

Display systems connect a protein with the DNA encoding it. Such systems (e.g., phage or ribosome display) have found widespread application in the directed evolution of protein binders and constitute a key element of the biotechnological toolkit. In this proof-of-concept study we describe the construction of a system that allows the display of multiple copies of a protein of interest in order to take advantage of avidity effects during affinity panning. To this end, dendrimer-like DNA is used as a scaffold with docking points that can join the coding DNA with multiple protein copies. Each DNA construct is compartmentalised in water-in-oil emulsion droplets. The corresponding protein is expressed, in vitro, inside the droplets as a SNAP-tag fusion. The covalent bond between DNA and the SNAP-tag is created by reaction with dendrimer-bound benzylguanine (BG). The ability to form dendrimer-like DNA straightforwardly from oligonucleotides bearing BG allowed the comparison of a series of templates differing in size, valency and position of BG. In model selections the most efficient constructs show recoveries of up to 0.86 % and up to 400-fold enrichments. The comparison of mono- and multivalent constructs suggests that the avidity effect enhances enrichment by up to fivefold and recovery by up to 25-fold. Our data establish a multivalent format for SNAP-display based on dendrimer-like DNA as the first in vitro display system with defined tailor-made valencies and explore a new application for DNA nanostructures. These data suggest that multivalent SNAP dendrimers have the potential to facilitate the selection of protein binders especially during early rounds of directed evolution, allowing a larger diversity of candidate binders to be recovered. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Electrostatic dry powder prepregging of carbon fiber

NASA Technical Reports Server (NTRS)

Throne, James L.; Sohn, Min-Seok

1990-01-01

Ultrafine, 5-10 micron polymer-matrix resin powders are directly applied to carbon fiber tows by passing then in an air or nitrogen stream through an electrostatic potential; the particles thus charged will strongly adhere to grounded carbon fibers, and can be subsequently fused to the fiber in a continuously-fed radiant oven. This electrostatic technique derived significant end-use mechanical property advantages from the obviation of solvents, binders, and other adulterants. Additional matrix resins used to produce prepregs to date have been PMR-15, Torlon 40000, and LaRC TPI.

Abdominal binders may reduce pain and improve physical function after major abdominal surgery - a systematic review.

PubMed

Rothman, Josephine Philip; Gunnarsson, Ulf; Bisgaard, Thue

2014-11-01

Evidence for the effect of post-operative abdominal binders on post-operative pain, seroma formation, physical function, pulmonary function and increased intra-abdominal pressure among patients after surgery remains largely un-investigated. A systematic review was conducted. The PubMed, EMBASE and Cochrane databases were searched for studies on the use of abdominal binders after abdominal surgery or abdominoplasty. All types of clinical studies were included. Two independent assessors evaluated the scientific quality of the studies. The primary outcomes were pain, seroma formation and physical function. A total of 50 publications were identified; 42 publications were excluded leaving eight publications counting a total of 578 patients for analysis. Generally, the scientific quality of the studies was poor. Use of abdominal binder revealed a non-significant tendency to reduce seroma formation after laparoscopic ventral herniotomy and a non-significant reduction in pain. Physical function was improved, whereas evidence supports a beneficial effect on psychological distress after open abdominal surgery. Evidence also supports that intra-abdominal pressure increases with the use of abdominal binders. Reduction of pulmonary function during use of abdominal binders has not been revealed. Abdominal binders reduce post-operative psychological distress, but their effect on post-operative pain after laparotomy and seroma formation after ventral hernia repair remains unclear. Due to the sparse evidence and poor quality of the literature, solid conclusions may be difficult to make, and procedure-specific, high-quality randomised clinical trials are warranted.

Development of an advanced, continuous mild gasification process for the production of co-products. Quarterly report, October 30, 1991--January 2, 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

O`Neal, G.W.

1991-12-31

During this quarter the work on Task 3, char upgrading, was in two areas; upgrading Penelec char made from Penelec filter cake to blast furnace formed coke, and evaluating various bituminous pitch binders. The formed coke from Penelec filter cake was of good quality with a high crush strength of 3000 pounds. The reactivity was not equal to that of conventional coke but it is felt that it could be made to equal conventional coke with further study, specifically by adding binder coal to the raw material recipe. The work evaluating bituminous pitch binders confirmed earlier thinking that will bemore » valuable to a commercial scale-up. Asphalt binders are compatible with coal tar binders and produce a coke of equal quality. Hence asphalt binders can be used to supply deficiencies of tar production in units employing coals with insufficient volatile matter to supply enough tar for the coking process. Asphalt binders have about a 50% savings from coal tar pitch. During the 4th Quarter of 1991, a total of 15 Continuous Mild Gasification Unit (CMGU) test runs were made. Efforts continued to determine the optimum forward/reverse ratio to maximize coal feed rate. The success of these efforts has been limited with a maximum coal feed rate of 400 lbs/hr obtainable with a caking coal. The handicap of not having screw shaft heaters cannot be overcome by adjustment of the forward/reverse ratio.« less

Development of an advanced, continuous mild gasification process for the production of co-products

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Neal, G.W.

1991-01-01

During this quarter the work on Task 3, char upgrading, was in two areas; upgrading Penelec char made from Penelec filter cake to blast furnace formed coke, and evaluating various bituminous pitch binders. The formed coke from Penelec filter cake was of good quality with a high crush strength of 3000 pounds. The reactivity was not equal to that of conventional coke but it is felt that it could be made to equal conventional coke with further study, specifically by adding binder coal to the raw material recipe. The work evaluating bituminous pitch binders confirmed earlier thinking that will bemore » valuable to a commercial scale-up. Asphalt binders are compatible with coal tar binders and produce a coke of equal quality. Hence asphalt binders can be used to supply deficiencies of tar production in units employing coals with insufficient volatile matter to supply enough tar for the coking process. Asphalt binders have about a 50% savings from coal tar pitch. During the 4th Quarter of 1991, a total of 15 Continuous Mild Gasification Unit (CMGU) test runs were made. Efforts continued to determine the optimum forward/reverse ratio to maximize coal feed rate. The success of these efforts has been limited with a maximum coal feed rate of 400 lbs/hr obtainable with a caking coal. The handicap of not having screw shaft heaters cannot be overcome by adjustment of the forward/reverse ratio.« less

NOVEL BINDERS AND METHODS FOR AGGLOMERATION OF ORE

DOE Office of Scientific and Technical Information (OSTI.GOV)

S.K. Kawatra; T.C. Eisele; J.A. Gurtler

2004-04-01

Many metal extraction operations, such as leaching of copper, leaching of precious metals, and reduction of metal oxides to metal in high-temperature furnaces, require agglomeration of ore to ensure that reactive liquids or gases are evenly distributed throughout the ore being processed. Agglomeration of ore into coarse, porous masses achieves this even distribution of fluids by preventing fine particles from migrating and clogging the spaces and channels between the larger ore particles. Binders are critically necessary to produce agglomerates that will not break down during processing. However, for many important metal extraction processes there are no binders known that willmore » work satisfactorily. Primary examples of this are copper heap leaching, where there are no binders that will work in the acidic environment encountered in this process, and advanced ironmaking processes, where binders must function satisfactorily over an extraordinarily large range of temperatures (from room temperature up to over 1200 C). As a result, operators of many facilities see a large loss of process efficiency due to their inability to take advantage of agglomeration. The large quantities of ore that must be handled in metal extraction processes also means that the binder must be inexpensive and useful at low dosages to be economical. The acid-resistant binders and agglomeration procedures developed in this project will also be adapted for use in improving the energy efficiency and performance of a broad range of mineral agglomeration applications, particularly heap leaching and advanced primary ironmaking.« less

Method for fabricating ceramic filaments and high density tape casting method

NASA Technical Reports Server (NTRS)

Collins, Jr., Earl R. (Inventor)

1990-01-01

An apparatus and method is disclosed for fabricating mats of ceramic material comprising preparing a slurry of ceramic particles in a binder/solvent, charging the slurry into a vessel, forcing the slurry from the vessel into spinneret nozzles, discharging the slurry from the nozzles into the path of airjets to enhance the sinuous character of the slurry exudate and to dry it, collecting the filaments on a moving belt so that the filaments overlap each other thereby forming a mat, curing the binder therein, compressing and sintering the mat to form a sintered mat, and crushing the sintered mat to produce filament shaped fragments. A process is also disclosed for producing a tape of densely packed, bonded ceramic particles comprising forming a slurry of ceramic particles and a binder/solvent, applying the slurry to a rotating internal molding surface, applying a large centrifugal force to the slurry to compress it and force excess binder/solvent from the particles, evaporating solvent and curing the binder thereby forming layers of bonded ceramic particles and cured binder, and separating the binder layer from the layer of particles. Multilayers of ceramic particles are cast in an analogous manner on top of previously formed layers. When all of the desired layers have been cast the tape is fired to produce a sintered tape. For example, a three-layer tape is produced having outer layers of highly compressed filament shaped fragments of strontium doped lanthanum (LSM) particles and a center layer of yttria stabilized zicronia (YSZ) particles.

Development of a discriminative biphasic in vitro dissolution test and correlation with in vivo pharmacokinetic studies for differently formulated racecadotril granules.

PubMed

Deng, Jia; Staufenbiel, Sven; Hao, Shilei; Wang, Bochu; Dashevskiy, Andriy; Bodmeier, Roland

2017-06-10

The purpose of this study was to discriminate the release behavior from three differently formulated racecadotril (BCS II) granules and to establish an in vitro-in vivo correlation. Three granule formulations of the lipophilic drug were prepared with equivalent composition but prepared with different manufacturing processes (dry granulation, wet granulation with or without binder). In vitro release of the three granules was investigated using a biphasic dissolution system (phosphate buffer pH6.8 and octanol) and compared to the conventional single phase USP II dissolution test performed under sink and non-sink conditions. In vivo studies with each granule formulation were performed in rats. Interestingly, the granule formulations exhibited pronouncedly different behavior in the different dissolution systems depending on different wetting and dissolution conditions. Single phase USP II dissolution tests lacked discrimination. In contrast, remarkable discrimination between the granule formulations was observed in the octanol phase of biphasic dissolution system with a rank order of release from granules prepared by wet granulation with binder>wet granulation without binder>dry granulation. This release order correlated well with the wettability of these granules. An excellent correlation was also established between in vitro release in the octanol phase of the biphasic test and in vivo data (R 2 =0.999). Compared to conventional dissolution methods, the biphasic method provides great potential to discriminate between only minor formulation and process changes within the same dosage form for poorly soluble drugs. Copyright © 2017 Elsevier B.V. All rights reserved.

RC beams shear-strengthened with fabric-reinforced-cementitious-matrix (FRCM) composite

NASA Astrophysics Data System (ADS)

Loreto, Giovanni; Babaeidarabad, Saman; Leardini, Lorenzo; Nanni, Antonio

2015-12-01

The interest in retrofit/rehabilitation of existing concrete structures has increased due to degradation and/or introduction of more stringent design requirements. Among the externally-bonded strengthening systems fiber-reinforced polymers is the most widely known technology. Despite its effectiveness as a material system, the presence of an organic binder has some drawbacks that could be addressed by using in its place a cementitious binder as in fabric-reinforced cementitious matrix (FRCM) systems. The purpose of this paper is to evaluate the behavior of reinforced concrete (RC) beams strengthened in shear with U-wraps made of FRCM. An extensive experimental program was undertaken in order to understand and characterize this composite when used as a strengthening system. The laboratory results demonstrate the technical viability of FRCM for shear strengthening of RC beams. Based on the experimental and analytical results, FRCM increases shear strength but not proportionally to the number of fabric plies installed. On the other hand, FRCM failure modes are related with a high consistency to the amount of external reinforcement applied. Design considerations based on the algorithms proposed by ACI guidelines are also provided.

Non-Sintered Nickel Electrode

DOEpatents

Bernard, Patrick; Dennig, Corinne; Cocciantelli, Jean-Michel; Alcorta, Jose; Coco, Isabelle

2002-01-01

A non-sintered nickel electrode contains a conductive support and a paste comprising an electrochemically active material containing nickel hydroxide and a binder which is a mixture of an elastomer and a crystalline polymer. The proportion of the elastomer is in the range 25% to 60% by weight of the binder and the proportion of the crystalline polymer is in the range 40% to 75% by weight of the binder.

Kwik Bond Polymers(R) high friction surface treatment.

DOT National Transportation Integrated Search

2015-12-01

High friction surface treatment (HFST) was applied to two on-ramps in the Seattle urban area to improve : friction resistance. The ramps were high accident locations. The system applied was polyester resin binder and : calcined bauxite aggregate. Tes...

Evaluation of Tyregrip(R) high-friction surfacing.

DOT National Transportation Integrated Search

2012-06-01

This report describes the installation of Tyregrip, a high friction surface, on a high accident location to reduce accident : rates. Tyregrip is a thin polymer overlay system that uses a two part epoxy binder and calcined bauxite aggregate. Postc...

Shock initiation of an ɛ-CL-20-estane formulation

NASA Astrophysics Data System (ADS)

Tarver, C. M.; Simpson, R. L.; Urtiew, P. A.

1996-05-01

The shock sensitivity of a pressed solid explosive formulation, LX-19, containing 95.2% by weight epsilon phase 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (HNIW) and 4.8% Estane binder, was determined using the wedge test and embedded manganin pressure gauge techniques. This formulation was shown to be slightly more sensitive than LX-14, which contains 95.5% HMX and 4.5% Estane binder. The measured pressure histories for LX-19 were very similar to those obtained using several HMX-inert binder formulations. An Ignition and Growth reactive flow model for LX-19 was developed which differed from those for HMX-inert binder formulations only by a 25% higher hot spot growth rate.

Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.

PubMed

Hall, Justin D; Wang, Hong; Byrnes, Laura J; Shanker, Suman; Wang, Kelong; Efremov, Ivan V; Chong, P Andrew; Forman-Kay, Julie D; Aulabaugh, Ann E

2016-02-01

The most common mutation in cystic fibrosis (CF) patients is deletion of F508 (ΔF508) in the first nucleotide binding domain (NBD1) of the CF transmembrane conductance regulator (CFTR). ΔF508 causes a decrease in the trafficking of CFTR to the cell surface and reduces the thermal stability of isolated NBD1; it is well established that both of these effects can be rescued by additional revertant mutations in NBD1. The current paradigm in CF small molecule drug discovery is that, like revertant mutations, a path may exist to ΔF508 CFTR correction through a small molecule chaperone binding to NBD1. We, therefore, set out to find small molecule binders of NBD1 and test whether it is possible to develop these molecules into potent binders that increase CFTR trafficking in CF-patient-derived human bronchial epithelial cells. Several fragments were identified that bind NBD1 at either the CFFT-001 site or the BIA site. However, repeated attempts to improve the affinity of these fragments resulted in only modest gains. Although these results cannot prove that there is no possibility of finding a high-affinity small molecule binder of NBD1, they are discouraging and lead us to hypothesize that the nature of these two binding sites, and isolated NBD1 itself, may not contain the features needed to build high-affinity interactions. Future work in this area may, therefore, require constructs including other domains of CFTR in addition to NBD1, if high-affinity small molecule binding is to be achieved. © 2016 The Protein Society.

Buckling Modes of Structural Elements of Off-Axis Fiber-Reinforced Plastics

NASA Astrophysics Data System (ADS)

Paimushin, V. N.; Polyakova, N. V.; Kholmogorov, S. A.; Shishov, M. A.

2018-05-01

The structures of two types of unidirectional fiber-reinforced composites — with an ELUR-P carbon fiber tape, an XT-118 cold-cure binder with an HSE 180 REM prepreg, and a hot-cure binder — were investigated. The diameters of fibers and fiber bundles (threads) of both the types of composites were measured, and their mutual arrangement was examined both in the semifinished products (in the uncured state) and in the finished composites. The defects characteristic of both the types of binder and manufacturing technique were detected in the cured composites. Based on an analysis of the results obtained, linearized problems on the internal multiscale buckling modes of an individual fiber (with and without account of its interaction with the surrounding matrix) or of a fiber bundle are formulated. In the initial atate, these structural elements of the fibrous composites are in a subcritical (unperturbed) state under the action of shear stresses and tension (compression) in the transverse direction. Such an initial stress state is formed in them in tension and compression tests on flat specimens made of off-axis-reinforced composites with straight fibers. To formulate the problems, the equations derived earlier from a consistent variant of geometrically nonlinear equations of elasticity theory by reducing them to the one-dimensional equations of the theory of straight rods on the basis of a refined Timoshenko shear model with account of tensile-compressive strains in the transverse direction are used. It is shown that, in loading test specimens, a continuous rearrangement of composite structure can occur due to the realization and continuous change of internal buckling modes as the wave-formation parameter varies continuously, which apparently explain the decrease revealed in the tangential shear modulus of the fibrous composites with increasing shear strains.

Carbazole ligands as c-myc G-quadruplex binders.

PubMed

Głuszyńska, Agata; Juskowiak, Bernard; Kuta-Siejkowska, Martyna; Hoffmann, Marcin; Haider, Shozeb

2018-07-15

The interactions of c-myc G-quadruplex with three carbazole derivatives were investigated by UV-Vis spectrophotometry, fluorescence, CD spectroscopy, and molecular modeling. The results showed that a combination of carbazole scaffold functionalized with ethyl, triazole and imidazole groups resulted in stabilization of the intramolecular G-quadruplex formed by the DNA sequence derived from the NHE III 1 region of c-myc oncogene (Pu22). Binding to the G-quadruplex Pu22 resulted in the significant increase in fluorescence intensity of complexed ligands 1-3. All ligands were capable of interacting with G4 DNA with binding stoichiometry indicating that two ligand molecules bind to G-quadruplex with comparable affinity, which agrees with binding model of end-stacking on terminal G-tetrads. Copyright © 2018 Elsevier B.V. All rights reserved.

Advanced Graphene-Based Binder-Free Electrodes for High-Performance Energy Storage.

PubMed

Ji, Junyi; Li, Yang; Peng, Wenchao; Zhang, Guoliang; Zhang, Fengbao; Fan, Xiaobin

2015-09-23

The increasing demand for energy has triggered tremendous research effort for the development of high-performance and durable energy-storage devices. Advanced graphene-based electrodes with high electrical conductivity and ion accessibility can exhibit superior electrochemical performance in energy-storage devices. Among them, binder-free configurations can enhance the electron conductivity of the electrode, which leads to a higher capacity by avoiding the addition of non-conductive and inactive binders. Graphene, a 2D material, can be fabricated into a porous and flexible structure with an interconnected conductive network. Such a conductive structure is favorable for both electron and ion transport to the entire electrode surface. In this review, the main processes used to prepare binder-free graphene-based hybrids with high porosity and well-designed electron conductive networks are summarized. Then, the applications of free-standing binder-free graphene-based electrodes in energy-storage devices are discussed. Future research aspects with regard to overcoming the technological bottlenecks are also proposed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs

PubMed Central

Goossens, Joline; Vandenbroucke, Virginie; Pasmans, Frank; De Baere, Siegrid; Devreese, Mathias; Osselaere, Ann; Verbrugghe, Elin; Haesebrouck, Freddy; De Saeger, Sarah; Eeckhout, Mia; Audenaert, Kris; Haesaert, Geert; De Backer, Patrick; Croubels, Siska

2012-01-01

It is recognized that mycotoxins can cause a variety of adverse health effects in animals, including altered gastrointestinal barrier function. It is the aim of the present study to determine whether mycotoxin-contaminated diets can alter the oral bioavailability of the antibiotics doxycycline and paromomycin in pigs, and whether a mycotoxin adsorbing agent included into diets interacts with those antibiotics. Experiments were conducted with pigs utilizing diets that contained blank feed, mycotoxin-contaminated feed (T-2 toxin or deoxynivalenol), mycotoxin-contaminated feed supplemented with a glucomannan mycotoxin binder, or blank feed supplemented with mycotoxin binder. Diets with T-2 toxin and binder or deoxynivalenol and binder induced increased plasma concentrations of doxycycline administered as single bolus in pigs compared to diets containing blank feed. These results suggest that complex interactions may occur between mycotoxins, mycotoxin binders, and antibiotics which could alter antibiotic bioavailability. This could have consequences for animal toxicity, withdrawal time for oral antibiotics, or public health. PMID:22606377

Characterization of polymeric binders for Metal Injection Molding (MIM) process

NASA Astrophysics Data System (ADS)

Adames, Juan M.

The Metal Injection Molding (MIM) process is an economically attractive method of producing large amounts of small and complex metallic parts. This is achieved by combining the productivity of injection molding with the versatility of sintering of metal particulates. In MIM, the powdered metal is blended with a plastic binder to obtain the feedstock. The binder imparts flowability to the blend at injection molding conditions and strength at ambient conditions. After molding, the binder is removed in a sequence of steps that usually involves solvent-extraction and polymer burn-out. Once the binder is removed, the metal particles are sintered. In this research several topics of the MIM process were studied to understand how the polymeric binder, similar to the one used in the sponsoring company, works. This was done by examining the compounding and water debinding processes, the rheological and thermal properties, and the microstructure of the binder/metal composite at different processing stages. The factors studied included the metal contents, the composition of the binder and the processing conditions. The three binders prepared during the course of this research were blends of a polyolefin, polyoxymethylene copolymer (POM) and a water-soluble polymer (WSP). The polyolefin resins included polypropylene (PP), high-density polyethylene (HDPE) and linear low-density polyethylene (LLDPE). The powdered metal in the feedstocks was 316 L stainless steel. The compounding studies were completed in an internal mixer under different conditions of temperature, rotational speed and feedstock composition. It was found that the metal concentration was the most important factor in determining the torque evolution curves. The observation of microstructure with Scanning Electron Microscope (SEM) at different stages during compounding revealed that the metal particles neither agglomerate nor touch each other. The liquid extraction of the water-soluble polymer (WSP) from the molded parts (or water debinding) was investigated using two configurations of flow of water relative to the samples. Both permitted the reduction of the mass transfer resistance outside the parts, revealing information on the diffusion of the WSP inside the part exclusively. The debinding studies showed that a single effective diffusivity could be used to model the extraction process of the binder from molded parts. This approach is more accurate when the debinding time is above 2 hours. Steady shear and dynamic experiments were conducted on the binder and feedstocks samples containing LLDPE. The results of both experiments revealed that the feedstocks did not show yield stress even though the highest metal content was 64% by volume. Therefore, it was concluded that there were only hydrodynamic interactions between the metal particles. The thermal characterization of binders, polymers and feedstocks included differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The DSC tests were performed after preheating and quenching of the samples. The heating rate was 20°C/min. The TGA scans were conducted from room temperature to 700°C at 20°C/min. The DSC tests revealed that the melting point of the polymers depressed when blended in the binders and feedstocks. The depression was more intense for POM and the water-soluble polymer than for the polyolefins. Therefore, it was concluded that the melting point depression of POM and the water-soluble polymer was caused by their entrapment in the polyolefin matrix and in between the metal particles. The TGA scans showed that the feedstocks with higher metal concentration had higher final decomposition temperature, but similar onset temperature. The reason was that the higher the metal concentration the more difficult the diffusion of the products of the decomposition of the binder out of the samples. The morphological studies revealed that the binders were heterogeneous showing domains of the polar resins, embedded in a continuous phase composed of polyolefin. This distribution of phases was the result of the immiscibility between the polymeric components, and of the higher concentration (>70 vol%) of the polyolefin with respect to the polar components (polyoxymethylene and water-soluble polymer). The deformation during steady shear testing and compounding of the binder with the metal modified the size of the dispersed domains. The steady shearing increased the size of the dispersed domains by coalescence of the particles. On the other hand, the presence of powdered metal during compounding forced a redistribution of the dispersed phases. Apparently, a thin heterogeneous layer of binder surrounded the metal particles while most of the polyolefin occupied the space between the coated metal particles. The SEM study on samples obtained after water debinding revealed that the water-soluble polymer did not distribute uniformly on the surface of the molded disk of feedstock used for water debinding tests.

Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating.

PubMed

Serrano, Dolores R; Walsh, David; O'Connell, Peter; Mugheirbi, Naila A; Worku, Zelalem Ayenew; Bolas-Fernandez, Francisco; Galiana, Carolina; Dea-Ayuela, Maria Auxiliadora; Healy, Anne Marie

2018-03-01

Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the production of cocrystals, several issues can arise such as sublimation or stickiness due to low glass transition temperatures of some organic molecules, making the process very challenging. Even though, fluidised bed spray coating has been successfully employed in the production of amorphous drug-coated particles, to the best of our knowledge, it has never been employed in the production of cocrystals. The feasibility of this technique was proven using three model cocrystals: sulfadimidine (SDM)/4-aminosalicylic acid (4ASA), sulfadimidine/nicotinic acid (NA) and ibuprofen (IBU)/ nicotinamide (NAM). Design of experiments were performed to understand the critical formulation and process parameters that determine the formation of either cocrystal or coamorphous systems for SDM/4ASA. The amount and type of binder played a key role in the overall solid state and in vitro performance characteristics of the cocrystals. The optimal balance between high loading efficiencies and high degree of crystallinity was achieved only when a binder: cocrystal weight ratio of 5:95 or 10:90 was used. The cocrystal coated beads showed an improved in vitro-in vivo performance characterised by: (i) no tendency to aggregate in aqueous media compared to spray dried formulations, (ii) enhanced in vitro activity (1.8-fold greater) against S. aureus, (iii) larger oral absorption and bioavailability (2.2-fold higher C max ), (iv) greater flow properties and (v) improved chemical stability than cocrystals produced by other methods derived from the morphology and solid nature of the starter cores. Copyright © 2017 Elsevier B.V. All rights reserved.

Imaging Neuroinflammation in Post Traumatic Stress Disorder

DTIC Science & Technology

2012-11-01

Metabolite B = 0-30%), without evidence of lipophilic metabolites which can confound the analysis. 8 Figure 2 Left graph : Mean PSTD... graph : There is similar plasma protein binding of 18-F PBR111 in healthy and PTSD participants. Individual subject are data are indicated on the... graph . TSPO Binder status Both mixed and high afffinity TSPO binders were evident in the PTSD (4 high affinity binders, 4 mixed affinity

Classification and virtual screening of androgen receptor antagonists.

PubMed

Li, Jiazhong; Gramatica, Paola

2010-05-24

Computational tools, such as quantitative structure-activity relationship (QSAR), are highly useful as screening support for prioritization of substances of very high concern (SVHC). From the practical point of view, QSAR models should be effective to pick out more active rather than inactive compounds, expressed as sensitivity in classification works. This research investigates the classification of a big data set of endocrine-disrupting chemicals (EDCs)-androgen receptor (AR) antagonists, mainly aiming to improve the external sensitivity and to screen for potential AR binders. The kNN, lazy IB1, and ADTree methods and the consensus approach were used to build different models, which improve the sensitivity on external chemicals from 57.1% (literature) to 76.4%. Additionally, the models' predictive abilities were further validated on a blind collected data set (sensitivity: 85.7%). Then the proposed classifiers were used: (i) to distinguish a set of AR binders into antagonists and agonists; (ii) to screen a combined estrogen receptor binder database to find out possible chemicals that can bind to both AR and ER; and (iii) to virtually screen our in-house environmental chemical database. The in silico screening results suggest: (i) that some compounds can affect the normal endocrine system through a complex mechanism binding both to ER and AR; (ii) new EDCs, which are nonER binders, but can in silico bind to AR, are recognized; and (iii) about 20% of compounds in a big data set of environmental chemicals are predicted as new AR antagonists. The priority should be given to them to experimentally test the binding activities with AR.

Current and potential treatment options for hyperphosphatemia.

PubMed

Carfagna, Fabio; Del Vecchio, Lucia; Pontoriero, Giuseppe; Locatelli, Francesco

2018-06-01

Hyperphosphatemia is common in late stages of chronic kidney disease and is often associated with elevated parathormone levels, abnormal bone mineralization, extra-osseous calcification, and increased risk of cardiovascular events and death. Several classes of oral phosphate binders are available to help control plasma phosphorus levels. Although effective at lowering serum phosphorus, they all have safety, tolerability, and compliance issues that need to be considered when selecting which one to use. Areas covered: This paper reviews the most established treatment options for hyperphosphatemia, in patients with chronic kidney disease, focusing on the new inhibitors of active phosphate absorption. Expert opinion: The prevention and the treatment of hyperphosphatemia is today far to be satisfactory. Nonetheless, an extending range of phosphate binders are now available. Aluminum has potentially serious toxic risks. Calcium-based binders are very effective but can lead to hypercalcemia and/or positive calcium balance and progression of cardiovascular calcification. No long-term data are available for the new calcium acetate/magnesium combination product. Lanthanum is an effective phosphate binder, and long-term effects of tissue deposition seem clinically irrelevant. Sevelamer, appear to have profiles that would lead to pleiotropic effects and reduced progression of vascular calcification, and the main adverse events seen with these agents are gastrointestinal. Iron has a powerful capability of binding phosphate, thus numerous preparations are available, both with and without significant systemic absorption of the iron component. The inhibitors of active intestinal phosphate transport, with their very selective mechanism of action and low pill burden seem the most interesting approach; however, do not seem at present to be effective alone, in reducing serum phosphorus levels.

Effect of Binder Architecture on the Performance of Silicon/Graphite Composite Anodes for Lithium Ion Batteries

DOE PAGES

Cao, Peng-Fei; Naguib, Michael; Du, Zhijia; ...

2018-01-04

Although significant progress has been made in improving cycling performance of silicon-based electrodes, few studies have been performed on the architecture effect on polymer binder performance for lithium-ion batteries. A systematic study on the relationship between polymer architectures and binder performance is especially useful in designing synthetic polymer binders. In this paper, a graft block copolymer with readily tunable architecture parameters is synthesized and tested as the polymer binder for the high-mass loading silicon (15 wt %)/graphite (73 wt %) composite electrode (active materials >2.5 mg/cm 2). With the same chemical composition and functional group ratio, the graft block copolymermore » reveals improved cycling performance in both capacity retention (495 mAh/g vs 356 mAh/g at 100th cycle) and Coulombic efficiency (90.3% vs 88.1% at first cycle) than the physical mixing of glycol chitosan (GC) and lithium polyacrylate (LiPAA). Galvanostatic results also demonstrate the significant impacts of different architecture parameters of graft copolymers, including grafting density and side chain length, on their ultimate binder performance. Finally, by simply changing the side chain length of GC-g-LiPAA, the retaining delithiation capacity after 100 cycles varies from 347 mAh/g to 495 mAh/g.« less

[Study of the strength of compacts of mixed dry binders consisting of powdered cellulose and directly compressible lactose].

PubMed

Muzíková, J; Hájková, P; Vinklarová, S

2004-07-01

The paper studied the strength of compacts of dry binders consisting of powdered cellulose and directly compressible lactose. The powdered cellulose employed was Arbocel A300, the directly compressible lactose, Pharmatosa DCL 21. The first step of the evaluation comprised the tensile strength of compacts and sensitivity of dry binders alone to an addition of magnesium stearate. The same method of evaluation was then used for mixed dry binders from Arbocel A300 and Pharmatosa DCL 21 in ratios of 3:1, 1:1 and 1:3. The tested concentrations of magnesium stearate were 0.4 and 0.8%. Sensitivity of dry binders to an addition of the lubricant was evaluated by means of lubricant sensitivity ratio (LSR) values. The compacts with the highest strength and at the same time the lowest sensitivity to an addition of magnesium stearate were produced using a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3. The evaluation also included the commercially produced mixed dry binder Cellactosa 80, in which higher sensitivity to an addition of stearate than in a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3 was found.

Role of polymeric binders on mechanical behavior and cracking resistance of silicon composite electrodes during electrochemical cycling

NASA Astrophysics Data System (ADS)

Li, Dawei; Wang, Yikai; Hu, Jiazhi; Lu, Bo; Dang, Dingying; Zhang, Junqian; Cheng, Yang-Tse

2018-05-01

This work focuses on understanding the role of various binders, including sodium alginate (SA), Nafion, and polyvinylidene fluoride (PVDF), on the mechanical behavior and cracking resistance of silicon composite electrodes during electrochemical cycling. In situ curvature measurement of bilayer electrodes, consisting of a silicon-binder-carbon black composite layer on a copper foil, is used to determine the effects of binders on bending deformation, elastic modulus, and stress on the composite electrodes. It is found that the lithiation induced curvature and the modulus of the silicon/SA electrodes are larger than those of electrodes with Nafion and PVDF as binders. Although the modulus of Nafion is smaller than that of PVDF, the curvature and the modulus of silicon/Nafion composite are larger than those of silicon/PVDF electrodes. The moduli of all three composites decrease not only during lithiation but also during delithiation. Based on the measured stress and scanning electron microscopy observations of cracking in the composite electrodes, we conclude that the stress required to crack the composite electrodes with SA and Nafion binders is considerably higher than that of the silicon/PVDF electrode during electrochemical cycling. Thus, the cracking resistance of silicon/SA and silicon/Nafion composite electrodes is higher than that of silicon/PVDF electrodes.

Asphalt mixtures with a high amount of RAP - case study

NASA Astrophysics Data System (ADS)

Koudelka, Tomas; Varaus, Michal

2017-09-01

A case study of one trial section in the Pilsen region is presented. The pavement in the section was newly constructed in 2015 using one type of an asphalt concrete mixtures with varying RAP content. The constructed surface course comprises of 0% to 50% RAP. In order to restore the aged binder properties and to avoid the embrittlement of the produced mixtures, a rubber-based modifier/rejuvenator was employed. For technological reasons during manufacturing processes, which engage a parallel drying drum, a crude oil-based rejuvenator was also added. This article contains the preliminary data from an on-going project focused on monitoring the properties of bituminous binders contained in asphalt mixtures. The actual bituminous binders were extracted straight after production, after 6 months and after 12 months. The binder characteristics are evaluated using empirical testing as well as functional tests. Low temperature properties are measured by a Bending Beam Rheometer (BBR). The preliminary results show, that the bituminous binders properties change significantly in a relatively short period of time. The progress in binder’ characteristics is contradictory to up-to date knowledge. The probability that the phenomenon of diffusion between aged binder and rejuvenator agents occurs exists. Moreover, the data might indicate that the process of rejuvenator evaporation takes place.

Effect of Binder Architecture on the Performance of Silicon/Graphite Composite Anodes for Lithium Ion Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cao, Peng-Fei; Naguib, Michael; Du, Zhijia

Although significant progress has been made in improving cycling performance of silicon-based electrodes, few studies have been performed on the architecture effect on polymer binder performance for lithium-ion batteries. A systematic study on the relationship between polymer architectures and binder performance is especially useful in designing synthetic polymer binders. In this paper, a graft block copolymer with readily tunable architecture parameters is synthesized and tested as the polymer binder for the high-mass loading silicon (15 wt %)/graphite (73 wt %) composite electrode (active materials >2.5 mg/cm 2). With the same chemical composition and functional group ratio, the graft block copolymermore » reveals improved cycling performance in both capacity retention (495 mAh/g vs 356 mAh/g at 100th cycle) and Coulombic efficiency (90.3% vs 88.1% at first cycle) than the physical mixing of glycol chitosan (GC) and lithium polyacrylate (LiPAA). Galvanostatic results also demonstrate the significant impacts of different architecture parameters of graft copolymers, including grafting density and side chain length, on their ultimate binder performance. Finally, by simply changing the side chain length of GC-g-LiPAA, the retaining delithiation capacity after 100 cycles varies from 347 mAh/g to 495 mAh/g.« less

NOVEL BINDERS AND METHODS FOR AGGLOMERATION OF ORE

DOE Office of Scientific and Technical Information (OSTI.GOV)

S.K. Kawatra; T.C. Eisele; J.A. Gurtler

2005-04-01

Many metal extraction operations, such as leaching of copper, leaching of precious metals, and reduction of metal oxides to metal in high-temperature furnaces, require agglomeration of ore to ensure that reactive liquids or gases are evenly distributed throughout the ore being processed. Agglomeration of ore into coarse, porous masses achieves this even distribution of fluids by preventing fine particles from migrating and clogging the spaces and channels between the larger ore particles. Binders are critically necessary to produce agglomerates that will not breakdown during processing. However, for many important metal extraction processes there are no binders known that will workmore » satisfactorily. Primary examples of this are copper heap leaching, where there are no binders that will work in the acidic environment encountered in this process. As a result, operators of many facilities see large loss of process efficiency due to their inability to take advantage of agglomeration. The large quantities of ore that must be handled in metal extraction processes also means that the binder must be inexpensive and useful at low dosages to be economical. The acid-resistant binders and agglomeration procedures developed in this project will also be adapted for use in improving the energy efficiency and performance of a broad range of mineral agglomeration applications, particularly heap leaching.« less

Novel Binders and Methods for Agglomeration of Ore

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. K. Kawatra; T. C. Eisele; J. A. Gurtler

2004-03-31

Many metal extraction operations, such as leaching of copper, leaching of precious metals, and reduction of metal oxides to metal in high-temperature furnaces, require agglomeration of ore to ensure that reactive liquids or gases are evenly distributed throughout the ore being processed. Agglomeration of ore into coarse, porous masses achieves this even distribution of fluids by preventing fine particles from migrating and clogging the spaces and channels between the larger ore particles. Binders are critically necessary to produce agglomerates that will not break down during processing. However, for many important metal extraction processes there are no binders known that willmore » work satisfactorily. A primary example of this is copper heap leaching, where there are no binders that will work in the acidic environment encountered in this process. As a result, operators of acidic heap-leach facilities see a large loss of process efficiency due to their inability to take advantage of agglomeration. The large quantities of ore that must be handled in metal extraction processes also means that the binder must be inexpensive and useful at low dosages to be economical. The acid-resistant binders and agglomeration procedures developed in this project will also be adapted for use in improving the energy efficiency and performance of other agglomeration applications, particularly advanced primary ironmaking.« less

Performance characterizations of asphalt binders and mixtures incorporating silane additive ZycoTherm

NASA Astrophysics Data System (ADS)

Hasan, Mohd Rosli Mohd; Hamzah, Meor Othman; Yee, Teh Sek

2017-10-01

Experimental works were conducted to evaluate the properties of asphalt binders and mixtures produced using a relatively new silane additive, named ZycoTherm. In this study, 0.1wt% ZycoTherm was blended with asphalt binder to enable production of asphalt mixture at lower than normal temperatures, as well as improve mix workability and compactability. Asphalt mixture performances towards pavement distresses in tropical climate region were also investigated. The properties of control asphalt binders (60/70 and 80/10 penetration grade) and asphalt binders incorporating 0.1% ZycoTherm were reported based on the penetration, softening point, rotational viscosity, complex modulus and phase angle. Subsequently, to compare the performance of asphalt mixture incorporating ZycoTherm with the control asphalt mixture, cylindrical samples were prepared at recommended temperatures and air voids depending on the binder types and test requirements. The samples were tested for indirect tensile strength (ITS), resilient modulus, dynamic creep, Hamburg wheel tracking and moisture induced damage. From compaction data using the Servopak gyratory compactor, specimen prepared using ZycoTherm exhibit higher workability and compactability compared to the conventional mixture. From the mixture performance test results, mixtures prepared with ZycoTherm showed comparable if not better performance than the control sample in terms of the resistance to moisture damage, permanent deformation and cracking.

Effect of rapid set binder on early strength and permeability of HES latex modified road repair pre-packed concrete

NASA Astrophysics Data System (ADS)

Han, J. W.; Lee, S. K.; Yu, C.; Park, C. G.

2015-12-01

The early strength development characteristics and permeability resistance of high early strength (HES) pre-packed road repair concrete incorporating a rapid-set binder material were evaluated for emergency repairs to road pavement. The rapid-set binder is a mixture of rapid-set cement and silica sands whose fluidity improves with the addition of styrene butadiene latex (latex). The resulting mixture has a compressive strength of 21 MPa or higher and a flexural strength of greater than 3.5 MPa after 4 hours, the maximum curing age allowed for emergency repair materials. This study examines the strength development properties and permeability resistance of HES latex-modified pre-packed road repair concrete using a rapid- set binder as a function of the latex-to-binder mixing ratio at values of 0.40, 0.33, 0.29 and 0.25. Both early strength development properties and permeability resistance increased as the ratio of latex to rapid-set binder decreased. The mixture showed a compressive strength of 21 MPa or higher after 4 hours, which is the design standard of emergency repair concrete, only when this ratio was 0.29 or lower. A flexural strength of 3.5 MPa or greater was observed after hours only when this ratio was 0.33 or lower. The standard for permeability resistance, less than 2,000 C of chloride after 7 days of curing, was satisfied by all ratios. The ratio of latex to rapid-set binder satisfying all of the conditions for an emergency road repair material was 0.29 or less.

The role of bentonite binders in single or concomitant mycotoxin contamination of chicken diets.

PubMed

Pappas, A C; Tsiplakou, E; Tsitsigiannis, D I; Georgiadou, M; Iliadi, M K; Sotirakoglou, K; Zervas, G

2016-08-01

Concomitant presence of mycotoxins is more likely to appear than a single mycotoxicosis since many mycotoxigenic fungi grow and produce their toxic metabolites under similar conditions. The present study was designed to evaluate the efficacy of 4 mycotoxin binders to protect meat-type chickens against single and concomitant administration in the feed of two mycotoxins, namely aflatoxin B1 (AFB1) and ochratoxin A (OTA) both at concentration of 0.1 mg/kg. A total of 440 as hatched, d-old, Ross 308 broilers were reared for 42 d. There were 11 dietary treatments. Chickens were fed on either an uncontaminated basal diet, basal diet and AFB1, basal with concomitant presence of AFB1 and OTA, basal diet and three binders A, B and C (1%) with or without AFB1 or basal diet and binder D (0.5%) with or without concomitant presence of AFB1 and OTA. Performance, carcass yield and several biochemical parameters were examined. Mycotoxin concentration in liver and breast muscle samples was determined. Broiler performance under concomitant mycotoxin contamination was poorer than that under single mycotoxicosis. Mycotoxin presence increased relative heart weight compared to that of broilers fed on uncontaminated diets. Only OTA and not AFB1 was detected and only in the liver. OTA concentration was four-fold lower in broilers fed on a diet with binder compared to those fed on contaminated diets without binder. In conclusion, the study revealed that binder composition and presence or not of multiple toxins may be important factors for optimum broiler performance under mycotoxicosis.

Improvements in Fabrication of Sand/Binder Cores for Casting

NASA Technical Reports Server (NTRS)

Bakhitiyarov, Sayavur I.; Overfelt, Ruel A.; Adanur, Sabit

2005-01-01

Three improvements have been devised for the cold-box process, which is a special molding process used to make sand/binder cores for casting hollow metal parts. These improvements are: The use of fiber-reinforced composite binder materials (in contradistinction to the non-fiber-reinforced binders used heretofore), The substitution of a directed-vortex core-blowing subprocess for a prior core-blowing process that involved a movable gassing plate, and The use of filters made from filtration-grade fabrics to prevent clogging of vents. For reasons that exceed the scope of this article, most foundries have adopted the cold-box process for making cores for casting metals. However, this process is not widely known outside the metal-casting industry; therefore, a description of pertinent aspects of the cold-box process is prerequisite to a meaningful description of the aforementioned improvements. In the cold-box process as practiced heretofore, sand is first mixed with a phenolic resin (considered to be part 1 of a three-part binder) and an isocyanate resin (part 2 of the binder). Then by use of compressed air, the mixture is blown into a core box, which is a mold for forming the core. Next, an amine gas (part 3 of the binder) that acts as a catalyst for polymerization of parts 1 and 2 is blown through the core box. Alternatively, a liquid amine that vaporizes during polymerization can be incorporated into the sand/resin mixture. Once polymerization is complete, the amine gas is purged from the core box by use of compressed air. The finished core is then removed from the core box.

Intensive Hemodialysis, Mineral and Bone Disorder, and Phosphate Binder Use.

PubMed

Copland, Michael; Komenda, Paul; Weinhandl, Eric D; McCullough, Peter A; Morfin, Jose A

2016-11-01

Mineral and bone disorder is a common complication of end-stage renal disease. Notably, hyperphosphatemia likely promotes calcification of the myocardium, valves, and arteries. Hyperphosphatemia is associated with higher risk for cardiovascular mortality and morbidity along a gradient beginning at 5.0mg/dL. Among contemporary hemodialysis (HD) patients, mean serum phosphorus level is 5.2mg/dL, although 25% of patients have serum phosphorus levels of 5.5 to 6.9mg/dL; and 13%, >7.0mg/dL. Treatment of hyperphosphatemia is burdensome. Dialysis patients consume a mean of 19 pills per day, half of which are phosphate binders. Medicare Part D expenditures on binders for dialysis patients approached $700 million in 2013. Phosphorus removal with thrice-weekly HD (4 hours per session) is ∼3,000mg/wk. However, clearance is unlikely to counterbalance dietary intake, which varies around a mean of 7,000mg/wk. Dietary restriction and phosphate binders are important interventions, but each has limitations. Dietary control is complicated by limited access to healthy food choices and unclear labeling. Meanwhile, adherence to phosphate binders is poor, especially in younger patients and those with high pill burden. Multiple randomized clinical trials show that intensive HD reduces serum phosphorus levels. In the Frequent Hemodialysis Network (FHN) trial, short daily and nocturnal schedules reduced serum phosphorus levels by 0.6 and 1.6mg/dL, respectively, relative to 3 sessions per week. A similar effect of nocturnal HD was observed in an earlier trial. In the daily arm of the FHN trial, intensive HD significantly lowered estimated phosphate binder dose per day, whereas in the nocturnal arm, intensive HD led to binder discontinuation in 75% of patients. However, intensive HD appears to have no meaningful effects on serum calcium and parathyroid hormone concentrations. In conclusion, intensive HD, especially nocturnal HD, lowers serum phosphorus levels and decreases the need for phosphate binders. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Method to produce durable pellets at lower energy consumption using high moisture corn stover and a corn starch binder in a flat die pellet mill

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tumuluru, Jaya Shankar; Conner, Craig C.; Hoover, Amber N.

Biomass from plants can serve as an alternative renewable energy resources for energy production. Low densities of 40–60 kg/m3 for ground lignocellulosic biomass like corn stover limit its operation for energy purposes. The common drawbacks are inefficient transportation, a bigger storage foot print, and handling problems. Densification of biomass using pellet mill helps to overcome these limitations. This study helps to understand the effect of binder on high moisture biomass with a focus on the quality (density and durability), the pelleting efficiency and the specific energy consumption of its pelleting process. Raw corn stover was pelleted at high moisture ofmore » 33% (w.b.) at both varying preheating temperatures and binder percentage. The die speed of the pellet mill was set at 60Hz. The pellets produced were analyzed and showed higher moisture content. They were further dried in a laboratory oven at 70°C for 3-4 hr bringing the pellet moisture to <9%. The dried pellets were evaluated for their physical properties like unit, bulk and tapped density, and durability. Furthermore, the results indicated increasing the binder percentage to 4% improved the physical properties of the pellets and reduced the specific energy consumption. Higher binder addition of 4% reduced the feedstock moisture loss during pelleting to <4%, which can be due reduced residence time of the material in the die. On the other hand the physical properties like density and durability improved significantly with binder addition. At 4% binder and 33% feedstock moisture content, the bulk density and durability values observed were >510 kg/m3 and >98% and the percent fines generation has reduced to <3%. Also at these conditions the specific energy consumption was reduced by about 30-40% compared no binder pelleting test.« less

Method to produce durable pellets at lower energy consumption using high moisture corn stover and a corn starch binder in a flat die pellet mill

DOE PAGES

Tumuluru, Jaya Shankar; Conner, Craig C.; Hoover, Amber N.

2016-06-15

Biomass from plants can serve as an alternative renewable energy resources for energy production. Low densities of 40–60 kg/m3 for ground lignocellulosic biomass like corn stover limit its operation for energy purposes. The common drawbacks are inefficient transportation, a bigger storage foot print, and handling problems. Densification of biomass using pellet mill helps to overcome these limitations. This study helps to understand the effect of binder on high moisture biomass with a focus on the quality (density and durability), the pelleting efficiency and the specific energy consumption of its pelleting process. Raw corn stover was pelleted at high moisture ofmore » 33% (w.b.) at both varying preheating temperatures and binder percentage. The die speed of the pellet mill was set at 60Hz. The pellets produced were analyzed and showed higher moisture content. They were further dried in a laboratory oven at 70°C for 3-4 hr bringing the pellet moisture to <9%. The dried pellets were evaluated for their physical properties like unit, bulk and tapped density, and durability. Furthermore, the results indicated increasing the binder percentage to 4% improved the physical properties of the pellets and reduced the specific energy consumption. Higher binder addition of 4% reduced the feedstock moisture loss during pelleting to <4%, which can be due reduced residence time of the material in the die. On the other hand the physical properties like density and durability improved significantly with binder addition. At 4% binder and 33% feedstock moisture content, the bulk density and durability values observed were >510 kg/m3 and >98% and the percent fines generation has reduced to <3%. Also at these conditions the specific energy consumption was reduced by about 30-40% compared no binder pelleting test.« less

A novel approach to support formulation design on twin screw wet granulation technology: Understanding the impact of overarching excipient properties on drug product quality attributes.

PubMed

Willecke, N; Szepes, A; Wunderlich, M; Remon, J P; Vervaet, C; De Beer, T

2018-04-21

The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based formulation design and formulation optimization. Three principal components which represent the overarching properties of 8 selected pharmaceutical fillers were used as factors, whereas factors 4 and 5 represented binder type and binder concentration in a design of experiments (DoE). The majority of process parameters were kept constant to minimize their influence on the granule and drug product quality. 27 DoE batches consisting of binary filler/binder mixtures were processed via continuous twin screw wet granulation followed by tablet compression. Multiple linear regression models were built providing understanding of the impact of filler and binder properties on granule and tablet quality attributes (i.e. 16 DoE responses). The impact of fillers on the granule and tablet responses was more dominant compared to the impact of binder type and concentration. The filler properties had a relevant effect on granule characteristics, such as particle size, friability and specific surface area. Binder type and concentration revealed a relevant influence on granule flowability and friability as well as on the compactability (required compression force during tableting to obtain target hardness). In order to evaluate the DoE models' validity, a verification of the DoE models was performed with new formulations (i.e. a new combination of filler, binder type and binder concentration) which were initially not included in the dataset used to build the DoE models. The combined PCA (principle component analysis)/DoE approach allowed to link the excipient properties with the drug product quality attributes. Copyright © 2018 Elsevier B.V. All rights reserved.

Evaluation of the binding effect of human serum albumin on the properties of granules.

PubMed

Kristó, Katalin; Bajdik, János; Eros, István; Pintye-Hódi, Klára

2008-11-01

The main objective of this study was the application of a solution of human serum albumin as a granulating fluid. The properties of the granules formed were evaluated and compared with those when a conventional binder was applied in the same concentration. The powder mixture contained a soluble (mannitol) and an insoluble component (different types of cellulose). The protein solution applied exerted an appropriate aggregating effect if the system contained microcrystalline celluloses. Powdered cellulose was not suitable for the granulation with human serum albumin solution. As compared with the same concentration of the conventionally applied cellulose ethers as binder, the prepared granules exhibited a larger particle size, a significantly better compressibility, a higher breaking hardness and a favourable deformation process. These findings mainly reflect the good adhesive properties of the protein. The best compressibility and mechanical behaviour were attained on the application of the microcrystalline cellulose Vivapur type 105. This favourable behaviour may be connected with the wettability of cellulose. These results suggest that the formulation of tablets may be easier from an active agent in the serum that binds to albumin (e.g. interferon) since the amount of additives (binder) can be reduced.

Fast reactions of aluminum and explosive decomposition products in a post-detonation environment

NASA Astrophysics Data System (ADS)

Tappan, Bryce C.; Manner, Virginia W.; Lloyd, Joseph M.; Pemberton, Steven J.

2012-03-01

In order to determine the reaction behavior of Al in RDX or HMX/cast-cured binder formulations shortly after the passage of the detonation, a series of cylinder tests was performed on formulations comprising of varying binder systems and either 3.5 μm spherical Al or LiF (an inert salt with a similar molecular weight and density to Al). In these studies, both detonation velocity and cylinder expansion velocity are measured in order to determine exactly how and when Al contributes to the explosive event, particularly in the presence of oxidizing/energetic binders. The U.S. Army Research, Development and Engineering Laboratory at Picatinny have recently coined the term "combined effects" explosives for materials such as these; as they demonstrate both high metal pushing capability and high blast ability. This study is aimed at developing a fundamental understanding of the reaction of Al with explosives decomposition products, where both the detonation and early post-detonation environment are analyzed. Reaction rates of Al metal are investigated via comparison of predicted performance based on thermoequilibrium calculations. The detonation velocities, wall velocities, and parameters at the CJ plane are some of the parameters that will be discussed.

Pharmacology of the Phosphate Binder, Lanthanum Carbonate

PubMed Central

Damment, Stephen JP

2011-01-01

Studies were conducted to compare the phosphate-binding efficacy of lanthanum carbonate directly with other clinically used phosphate binders and to evaluate any potential adverse pharmacology. To examine the phosphate-binding efficacy, rats with normal renal function and chronic renal failure received lanthanum carbonate, aluminum hydroxide, calcium carbonate, or sevelamer hydrochloride in several experimental models. Lanthanum carbonate and aluminum hydroxide markedly increased excretion of [32P]-phosphate in feces and reduced excretion in urine in rats with normal renal function (p < 0.05), indicating good dietary phosphate-binding efficacy. In rats with chronic renal failure, lanthanum carbonate and aluminum hydroxide reduced urinary phosphate excretion to a greater degree and more rapidly than calcium carbonate, which in turn was more effective than sevelamer hydrochloride. The potential to induce adverse pharmacological effects was assessed systematically in mice, rats, and dogs with normal renal function using standard in vivo models. There was no evidence of any adverse secondary pharmacological effects of lanthanum carbonate on the central nervous, cardiovascular, respiratory, or gastrointestinal systems. These studies indicate that lanthanum carbonate is the more potent of the currently available dietary phosphate binders. No adverse secondary pharmacological actions were observed in vivo in a systematic evaluation at high doses. PMID:21332344

SABinder: A Web Service for Predicting Streptavidin-Binding Peptides.

PubMed

He, Bifang; Kang, Juanjuan; Ru, Beibei; Ding, Hui; Zhou, Peng; Huang, Jian

2016-01-01

Streptavidin is sometimes used as the intended target to screen phage-displayed combinatorial peptide libraries for streptavidin-binding peptides (SBPs). More often in the biopanning system, however, streptavidin is just a commonly used anchoring molecule that can efficiently capture the biotinylated target. In this case, SBPs creeping into the biopanning results are not desired binders but target-unrelated peptides (TUP). Taking them as intended binders may mislead subsequent studies. Therefore, it is important to find if a peptide is likely to be an SBP when streptavidin is either the intended target or just the anchoring molecule. In this paper, we describe an SVM-based ensemble predictor called SABinder. It is the first predictor for SBP. The model was built with the feature of optimized dipeptide composition. It was observed that 89.20% (MCC = 0.78; AUC = 0.93; permutation test, p < 0.001) of peptides were correctly classified. As a web server, SABinder is freely accessible. The tool provides a highly efficient way to exclude potential SBP when they are TUP or to facilitate identification of possibly new SBP when they are the desired binders. In either case, it will be helpful and can benefit related scientific community.

Experimental Investigation of Bio-Sealants Used for Pavement Preservation and Development of a New Strength Test for Asphalt Binders at Low Temperature

NASA Astrophysics Data System (ADS)

Ghosh, Debaroti

Surface treatment using sealants as a mean of pavement preservation is an important tool for cost-effectively extending service life of pavement. Sealants have become an important tool for cost-effectively extending the service life pavements. Due to the combined negative effects of asphalt aging and thermal cracking, it is always more challenging to choose an appropriate preservation technique for pavements built in cold-regions. Asphalt aging and thermal cracking negatively affect pavements built in cold climates. Therefore, it is important to evaluate the effects of sealants in laboratory conditions before application in the field to ensure effective performance. However, preservation activities cannot effectively address major distresses, such as low-temperature cracking, that can occur when the pavement was built from the very beginning with less durable materials. Therefore, an essential requirement to mitigate low-temperature cracking of pavements for asphalt materials used in the construction of pavement built in cold- regions is ensuring proper fracture properties of the asphalt materials used in construction. This study has two parts. In the first part, a laboratory evaluation of the effects of adding bio-sealants to both asphalt binder and mixture is performed. The goal is to obtain relevant properties of treated asphalt materials to understand the mechanism by which sealants improve pavement performance. For asphalt binders, a dynamic shear rheometer and a bending beam rheometer were used to obtain rheological properties of treated and untreated asphalt binders. For asphalt mixtures, field cores from both untreated and treated sections were collected and thin beam specimens were prepared from the cores to compare the creep and strength properties of the field-treated and laboratory-treated mixture. It is observed that the oil-based sealants have a significant softening effect on the control binder compared to the water-based sealant and traditional emulsion. Oil-based sealants increased rutting and fatigue potential of the binder and helped the low-temperature cracking resistance. For asphalt mixtures, different trends are observed for the field samples compared to the laboratory prepared samples. Similar to binder results, significant differences are observed between the asphalt mixtures treated with oil-based and water-based sealants, respectively. Additional analyses were performed to better understand the sealant effects. Fourier transform infrared spectroscopy (FTIR) analysis showed that the sealant products could not be detected in mixture samples collected from the surface of the treated section. Semi-empirical Hirsch model was able to predict asphalt mixture creep stiffness from binder stiffness. The results of a distress survey of the test sections correlated well with the laboratory findings. In the second part, a news binder strength testing method is proposed with the goal to provide an effective tool for selecting asphalt binders that are crack resistant. A modified Bending Beam Rheometer (BBR) is used to perform three-point bending strength tests, at constant loading rate, on asphalt binder beams at low temperature. Based on the results, a protocol for selecting the most crack resistant material from binders with similar rheological properties is proposed.

Long-Life and High-Power Binder-Free Cathode Based on One-Step Synthesis of Radical Polymers with Multi-Pendant Groups.

PubMed

Chen, Yaoguang; Zhang, Yangfan; Liu, Xiu; Fan, Xuliang; Bai, Bing; Yang, Kang; Liang, Zhongxin; Zhang, Zishou; Mai, Kancheng

2018-05-16

The main bottlenecks for the widespread application of radical polymers in organic radical batteries are poor cycling stability, due to the dissolution of radical polymers into the electrolyte, and the low efficiency of multi-step synthesis strategies. Herein, a kind of electrolyte-resistant radical polymer bearing multi-pendant groups (poly(ethylene-alt-TEMPO maleate) (PETM)) is designed and synthesized through a one-step esterification reaction to graft 4-hydroxy-2,2,6,6-teramethylpiperidinyl-1-oxy into the commercially available poly(ethylene-alt-maleic anhydride). Interestingly, PETM is hardly soluble in the ethylene carbonate/dimethyl carbonate/ethyl methyl carbonate-based electrolyte, showing an extremely low solubility of 0.59 mg mL -1 , but is easily soluble in tetrahydrofuran and N-Methyl pyrrolidone. The derived binder-free PETM cathode exhibits nearly 100% utilization of the grafted nitroxide radicals (88 mA h g -1 ) and excellent rate capability with almost invariant capacitance from 10 C to 40 C. Significantly, the PETM cathodes retain 94% of the initial capacity after 1000 cycles, outperforming most reported radical polymer-based cathodes. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Immobilization of long-lived radionuclides in carbon matrices produced with the use of polyimide binders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdulakhatov, Murat; Bartenev, Sergey; Firsin, Nikolai

Available in abstract form only. Full text of publication follows: Conditions for immobilization of long-lived radionuclides {sup 99}Tc, {sup 129}I and {sup 241}Am in carbon matrices were investigated by using their chemical analogs. Stable isotopes of rhenium, iodine and europium were used as chemical analogs of {sup 99}Tc, {sup 129}I and {sup 241}Am, respectively. It is shown that the carbon matrices incorporating the above elements can be produced by carbonization of composites with ITA-31 polyimide binder of the following composition: equal molar ratio between dianhydride of 3,3/,4,4/-benzophenone-tetracarboxylic acid and tetraacetyl derivative of 4,4/-diaminodiphenyl ester, radionuclide being investigated or its chemicalmore » analog and carbon fabric as reinforcing component. The elements under investigation were used both in the form of salts or oxides and in the form of their complexes with ion-exchange resins. The produced composites were carbonized in inert gas (argon) or in vacuum. The physical-chemical properties of the samples were studied. It was revealed that the resultant matrices meet the requirements imposed on waste storage and final disposal. (authors)« less

4D Imaging in Thermally Damaged Polymer-bonded Explosives

NASA Astrophysics Data System (ADS)

Parker, Gary; Bourne, Neil; Eastwood, David; Jacques, Simon; Dickson, Peter; Lopez-Pulliam, Ian; Heatwole, Eric; Holmes, Matt; Smilowitz, Laura; Rau, Christoph

2017-06-01

PBXs are composites in which explosive crystallites are bound by compliant polymers. There are safety benefits derived from compliant binders; e.g. they mitigate some effects of mechanical insult. However, during elevated thermal insult, degradation of binder and HE crystallites can modify the morphology in ways that can reduce safety margins by increasing post-ignition reaction violence. The response of thermally damaged PBXs, before and following self-ignition has safety implications and it is desirable to understand the fundamental physics controlling the rate of pre-ignition thermal runaway and the post-ignition flame propagation in thermal accident scenarios. Coupled with this there is an ongoing effort to make in situ, time-resolved, measurements of the size, nature and extent of micro-porosity in PBX 9501 during thermal decomposition. We report on PBX heating experiments conducted at the Diamond synchrotron with both PBX 9501 and an inert mock. During heating, CT radiography was conducted in order to observe void production and interconnectivity of gas flow pathways, as well as to monitor phase changes within the crystals. We explore the variation of behavior as a function of heating rate, soak temperature, soak time and confinement.

Surface Protection Study for Navy Projectiles,

DTIC Science & Technology

1997-01-01

an aluniinized-phenolic, an inorganic zinc, a two-part epoxy, a silicon-oxide, and an alkyd paint system as control. The main purpose was to...polyester, nylon, metallic-ceramic, aluminized-phenolic, inorganic zinc, silicon-oxide, alkyd paint system , corrosion resistance, abrasion resistance...environmental exposure. Acrylics and epoxies are commonly used paint binder systems which can be made water soluble for E-Coat applications. An epoxy E-Coat

Elastomeric binders for electrodes. [in secondary lithium cells

NASA Technical Reports Server (NTRS)

Yen, S. P. S.; Shen, D. H.; Somoano, R. B.

1983-01-01

The poor mechanical integrity of the cathode represents an important problem which affects the performance of ambient temperature secondary lithium cells. Repeated charge of a TiS2 cathode may give rise to stresses which disturb the electrode structure and can contribute to capacity loss. An investigation indicates that the use of an inelastic binder material, such as Teflon, aggravates the problem, and can lead to electrode disruption and poor TiS2 particle-particle contact. The feasibility of a use of elastomers as TiS2 binder materials has, therefore, been explored. It was found that elastomeric binders provide an effective approach for simplifying rechargeable cathode fabrication. A pronounced improvement in the mechanical integrity of the cathode structure contributes to a prolonged cycle life.

Composition for forming an optically transparent, superhydrophobic coating

DOEpatents

Simpson, John T.; Lewis, Linda A.

2015-12-29

A composition for producing an optically clear, well bonded superhydrophobic coating includes a plurality of hydrophobic particles comprising an average particle size of about 200 nm or less, a binder at a binder concentration of from about 0.1 wt. % to about 0.5 wt. %, and a solvent. The hydrophobic particles may be present in the composition at a particle concentration of from about 0.1 wt. % to about 1 wt. %. An optically transparent, superhydrophobic surface includes a substrate, a plurality of hydrophobic particles having an average particle size of about 200 nm or less dispersed over the substrate, and a discontinuous binder layer bonding the hydrophobic particles to the substrate, where the hydrophobic particles and the binder layer form an optically transparent, superhydrophobic coating.

The micromechanics model analysis of the viscosity regulation of ultra-high strength concrete with low viscosity

NASA Astrophysics Data System (ADS)

Zhu, M.; Wang, F. G.; Wang, F. Z.; Liu, Y. P.

2017-02-01

The plastic viscosity of mortar and concrete with different binder content, sand ratio, water-binder ratio, microbead dosage and different class and dosage of fly ash were tested and calculated according tomicromechanics model proposed by A. Ghanbari and B.L. Karihaloo, The correlations between these parameters and fresh concrete workability were also investigated, which showed i. high consistence with the objective reality. When binder content, microbead dosage, fly ash dosage or the water-binder ratio was increased or sand ratio was reduced, the fresh concrete viscosity would decrease correspondingly. However their effects were not that same. The relationships between T50 a, V-funnel and inverted slump time with fresh concrete viscosity were established, respectively.

Directly Grown Nanostructured Electrodes for High Volumetric Energy Density Binder-Free Hybrid Supercapacitors: A Case Study of CNTs//Li4Ti5O12

PubMed Central

Zuo, Wenhua; Wang, Chong; Li, Yuanyuan; Liu, Jinping

2015-01-01

Hybrid supercapacitor (HSC), which typically consists of a Li-ion battery electrode and an electric double-layer supercapacitor electrode, has been extensively investigated for large-scale applications such as hybrid electric vehicles, etc. Its application potential for thin-film downsized energy storage systems that always prefer high volumetric energy/power densities, however, has not yet been explored. Herein, as a case study, we develop an entirely binder-free HSC by using multiwalled carbon nanotube (MWCNT) network film as the cathode and Li4Ti5O12 (LTO) nanowire array as the anode and study the volumetric energy storage capability. Both the electrode materials are grown directly on carbon cloth current collector, ensuring robust mechanical/electrical contacts and flexibility. Our 3 V HSC device exhibits maximum volumetric energy density of ~4.38 mWh cm−3, much superior to those of previous supercapacitors based on thin-film electrodes fabricated directly on carbon cloth and even comparable to the commercial thin-film lithium battery. It also has volumetric power densities comparable to that of the commercial 5.5 V/100 mF supercapacitor (can be operated within 3 s) and has excellent cycling stability (~92% retention after 3000 cycles). The concept of utilizing binder-free electrodes to construct HSC for thin-film energy storage may be readily extended to other HSC electrode systems. PMID:25586374

Structure and properties of binder gels formed in the system Mg(OH)2-SiO2-H2O for immobilisation of Magnox sludge.

PubMed

Walling, Sam A; Kinoshita, Hajime; Bernal, Susan A; Collier, Nick C; Provis, John L

2015-05-07

A cementitious system for the immobilisation of magnesium rich Magnox sludge was produced by blending an Mg(OH)2 slurry with silica fume and an inorganic phosphate dispersant. The Mg(OH)2 was fully consumed after 28 days of curing, producing a disordered magnesium silicate hydrate (M-S-H) with cementitious properties. The structural characterisation of this M-S-H phase by (29)Si and (25)Mg MAS NMR showed clearly that it has strong nanostructural similarities to a disordered form of lizardite, and does not take on the talc-like structure as has been proposed in the past for M-S-H gels. The addition of sodium hexametaphosphate (NaPO3)6 as a dispersant enabled the material to be produced at a much lower water/solids ratio, while still maintaining the fluidity which is essential in practical applications, and producing a solid monolith. Significant retardation of M-S-H formation was observed with larger additions of phosphate, however the use of 1 wt% (NaPO3)6 was beneficial in increasing fluidity without a deleterious effect on M-S-H formation. This work has demonstrated the feasibility of using M-S-H as binder to structurally immobilise Magnox sludge, enabling the conversion of a waste into a cementitious binder with potentially very high waste loadings, and providing the first detailed nanostructural description of the material thus formed.

Atomistic Molecular Dynamics Simulations of Charged Latex Particle Surfaces in Aqueous Solution.

PubMed

Li, Zifeng; Van Dyk, Antony K; Fitzwater, Susan J; Fichthorn, Kristen A; Milner, Scott T

2016-01-19

Charged particles in aqueous suspension form an electrical double layer at their surfaces, which plays a key role in suspension properties. For example, binder particles in latex paint remain suspended in the can because of repulsive forces between overlapping double layers. Existing models of the double layer assume sharp interfaces bearing fixed uniform charge, and so cannot describe aqueous binder particle surfaces, which are soft and diffuse, and bear mobile charge from ionic surfactants as well as grafted multivalent oligomers. To treat this industrially important system, we use atomistic molecular dynamics simulations to investigate a structurally realistic model of commercial binder particle surfaces, informed by extensive characterization of particle synthesis and surface properties. We determine the interfacial profiles of polymer, water, bound and free ions, from which the charge density and electrostatic potential can be calculated. We extend the traditional definitions of the inner and outer Helmholtz planes to our diffuse interfaces. Beyond the Stern layer, the simulated electrostatic potential is well described by the Poisson-Boltzmann equation. The potential at the outer Helmholtz plane compares well to the experimental zeta potential. We compare particle surfaces bearing two types of charge groups, ionic surfactant and multivalent oligomers, with and without added salt. Although the bare charge density of a surface bearing multivalent oligomers is much higher than that of a surfactant-bearing surface at realistic coverage, greater counterion condensation leads to similar zeta potentials for the two systems.

Implementation of GPC characterization of asphalt binders at Louisiana materials laboratory : tech summary.

DOT National Transportation Integrated Search

2013-10-01

Asphalt is a mixture of a wide variety of chemical compounds that include aliphatic hydrocarbons and highly fused : aromatic ring systems. They are classi ed as asphaltenes (medium molecular weight) and maltenes (low molecular : weight). To improv...

40 CFR 63.1381 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fiberglass to which a phenol-formaldehyde binder has been applied. Building insulation means bonded wool fiberglass insulation, having a loss on ignition of less than 8 percent and a density of less than 32... includes foundations, superstructure and retaining walls, raw material charger systems, heat exchangers...

40 CFR 63.1381 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... fiberglass to which a phenol-formaldehyde binder has been applied. Building insulation means bonded wool fiberglass insulation, having a loss on ignition of less than 8 percent and a density of less than 32... includes foundations, superstructure and retaining walls, raw material charger systems, heat exchangers...

40 CFR 63.1381 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... fiberglass to which a phenol-formaldehyde binder has been applied. Building insulation means bonded wool fiberglass insulation, having a loss on ignition of less than 8 percent and a density of less than 32... includes foundations, superstructure and retaining walls, raw material charger systems, heat exchangers...

Economic Evaluation of Sevelamer versus Calcium-Based Phosphate Binders in Hemodialysis Patients: A Secondary Analysis using Centers for Medicare & Medicaid Services Data

PubMed Central

Fan, Qiao; Weinhandl, Eric; Liu, Jiannong

2009-01-01

Background and objectives: A secondary analysis of the Dialysis Clinical Outcomes Revisited (DCOR) trial suggested that sevelamer reduced hospitalizations relative to calcium-based phosphate binders. However, whether changed medical costs associated with reduced hospitalizations or other medical services offset the higher cost of sevelamer is unclear. This DCOR secondary analysis aimed to (1) evaluate Medicare total, inpatient, outpatient, skilled nursing facility, and other costs in sevelamer-treated versus calcium-treated patients; (2) examine Medicare costs in specific categories to determine cost drivers; and (3) estimate and incorporate sevelamer and calcium binder costs. Design, setting, participants, & measurements: DCOR trial participants were linked to the Centers for Medicare & Medicaid Services ESRD database. Medicare costs for 1895 dosed Medicare-primary-payer participants were evaluated. Phosphate binder costs were incorporated. Costs were indexed to 2001 (study base year). Sensitivity analyses were performed with randomized participants, two follow-up periods, and 2004 as index year. Results: Inflation-adjusted Medicare per member per month (PMPM) costs were lower for sevelamer-treated than for calcium-treated participants by a mean differential of $199 PMPM (mean, $5236 versus $5435; median, $4653 versus $4933), mainly because of lower inpatient costs for the sevelamer group (mean, $1461 versus $1644; median, $909 versus $1144). However, after phosphate binder costs were incorporated, costs trended lower for calcium-treated than for sevelamer-treated patients (differential −$81, 95% confidence interval −$321 to $157 PMPM, using average wholesale price; −$25, −$256 to $213 PMPM, using wholesale acquisition cost). Conclusions: Sevelamer reduced inpatient Medicare costs compared with calcium binders. However, when binder costs were added, overall PMPM costs favored calcium-treated over sevelamer-treated participants. PMID:19833904

Effect of Warm Asphalt Additive on the Creep and Recovery Behaviour of Aged Binder Containing Waste Engine Oil

NASA Astrophysics Data System (ADS)

Hassan, Norhidayah Abdul; Kamaruddin, Nurul Hidayah Mohd; Rosli Hainin, Mohd; Ezree Abdullah, Mohd

2017-08-01

The use of waste engine oil as an additive in asphalt mixture has been reported to be able to offset the stiffening effect caused by the recycled asphalt mixture. Additionally, the fumes and odor of the waste engine oil has caused an uncomfortable condition for the workers during road construction particularly at higher production temperature. Therefore, this problem was addressed by integrating chemical warm asphalt additive into the mixture which functions to reduce the mixing and compaction temperature. This study was initiated by blending the additive in the asphalt binder of bitumen penetration grade 80/100 prior to the addition of pavement mixture. The effect of chemical warm asphalt additive, Rediset WMX was investigated by modifying the aged binder containing waste engine oil with 0%, 1%, 2% and 3% by weight of the binder. The samples were then tested for determining the rutting behaviour under different loading stress levels of 3Pa (low), 10Pa (medium) and 50Pa (high) using Dynamic Shear Rheometer (DSR). A reference temperature of 60 °C was fixed to reflect the maximum temperature of the pavement. The results found that the addition of Rediset did not affect the creep and recovery behavior of the modified binder under different loading. On the other hand, 2% Rediset resulted a slight decrease in its rutting resistance as shown by the reduction of non-recoverable compliance under high load stress. However, overall, the inclusion of chemical warm asphalt additive to the modified binder did not adversely affect the rutting resistance which could be beneficial in lowering the temperature of asphalt production and simultaneously not compromising the binder properties.

Numerical simulation of stress distribution in Inconel 718 components realized by metal injection molding during supercritical debinding

NASA Astrophysics Data System (ADS)

Agne, Aboubakry; Barrière, Thierry

2018-05-01

Metal injection molding (MIM) is a process combining advantages of thermoplastic injection molding and powder metallurgy process in order to manufacture components with complex and near net-shape geometries. The debinding of a green component can be performed in two steps, first by using solvent debinding in order to extract the organic part of the binder and then by thermal degradation of the rest of the binder. A shorter and innovative method for extracting an organic binder involves the use of supercritical fluid instead of a regular solvent. The debinding via a supercritical fluid was recently investigated to extract organic binders contained in components obtained by Metal Injection Molding. It consists to put the component in an enclosure subjected to high pressure and temperature. The supercritical fluid has various properties depending on these two conditions, e.g., density and viscosity. The high-pressure combined with the high temperature during the process affect the component structure. Three mechanisms contributing to the deformation of the component can been differentiated: thermal expansion, binder extraction and supercritical fluid effect on the outer surfaces of the component. If one supposes that, the deformation due to binder extraction is negligible, thermal expansion and the fluid effect are probably the main mechanisms that can produce several stress. A finite-element model, which couples fluid-structures interaction and structural mechanics, has been developed and performed on the Comsol Multiphysics® finite-element software platform allowed to estimate the stress distribution during the supercritical debinding of MIM component composed of Inconel 718 powders, polypropylene, polyethylene glycol and stearic acid as binder. The proposed numerical simulations allow the estimation of the stress distribution with respect to the processing parameters for MIM components during the supercritical debinding process using a stationary solver.

Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation.

PubMed

Ciudad, M Teresa; Sorvillo, Nicoletta; van Alphen, Floris P; Catalán, Diego; Meijer, Alexander B; Voorberg, Jan; Jaraquemada, Dolores

2017-01-01

Dendritic cells (DCs) are the major professional APCs of the immune system; however, their MHC-II-associated peptide repertoires have been hard to analyze, mostly because of their scarce presence in blood and tissues. In vitro matured human monocyte-derived DCs (MoDCs) are widely used as professional APCs in experimental systems. In this work, we have applied mass spectrometry to identify the HLA-DR-associated self-peptide repertoires from small numbers of mature MoDCs (∼5 × 10 6 cells), derived from 7 different donors. Repertoires of 9 different HLA-DR alleles were defined from analysis of 1319 peptides, showing the expected characteristics of MHC-II-associated peptides. Most peptides identified were predicted high binders for their respective allele, formed nested sets, and belonged to endo-lysosomal pathway-degraded proteins. Approximately 20% of the peptides were derived from cytosolic and nuclear proteins, a recurrent finding in HLA-DR peptide repertoires. Of interest, most of these peptides corresponded to single sequences, did not form nested sets, and were located at the C terminus of the parental protein, which suggested alternative processing. Analysis of cleavage patterns for terminal peptides predominantly showed aspartic acid before the cleavage site of both C- and N-terminal peptides and proline immediately after the cleavage site in C-terminal peptides. Proline was also frequent next to the cut sites of internal peptides. These data provide new insights into the Ag processing capabilities of DCs. The relevance of these processing pathways and their contribution to response to infection, tolerance induction, or autoimmunity deserve further analysis. © Society for Leukocyte Biology.

Cobalt Oxide Porous Nanofibers Directly Grown on Conductive Substrate as a Binder/Additive-Free Lithium-Ion Battery Anode with High Capacity.

PubMed

Liu, Hao; Zheng, Zheng; Chen, Bochao; Liao, Libing; Wang, Xina

2017-12-01

In order to reduce the amount of inactive materials, such as binders and carbon additives in battery electrode, porous cobalt monoxide nanofibers were directly grown on conductive substrate as a binder/additive-free lithium-ion battery anode. This electrode exhibited very high specific discharging/charging capacities at various rates and good cycling stability. It was promising as high capacity anode materials for lithium-ion battery.

Collagen-based proteinaceous binder-pigment interaction study under UV ageing conditions by MALDI-TOF-MS and principal component analysis.

PubMed

Romero-Pastor, Julia; Navas, Natalia; Kuckova, Stepanka; Rodríguez-Navarro, Alejandro; Cardell, Carolina

2012-03-01

This study focuses on acquiring information on the degradation process of proteinaceous binders due to ultra violet (UV) radiation and possible interactions owing to the presence of historical mineral pigments. With this aim, three different paint model samples were prepared according to medieval recipes, using rabbit glue as proteinaceus binders. One of these model samples contained only the binder, and the other two were prepared by mixing each of the pigments (cinnabar or azurite) with the binder (glue tempera model samples). The model samples were studied by applying Principal Component Analysis (PCA) to their mass spectra obtained with Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS). The complementary use of Fourier Transform Infrared Spectroscopy to study conformational changes of secondary structure of the proteinaceous binder is also proposed. Ageing effects on the model samples after up to 3000 h of UV irradiation were periodically analyzed by the proposed approach. PCA on MS data proved capable of identifying significant changes in the model samples, and the results suggested different aging behavior based on the pigment present. This research represents the first attempt to use this approach (PCA on MALDI-TOF-MS data) in the field of Cultural Heritage and demonstrates the potential benefits in the study of proteinaceous artistic materials for purposes of conservation and restoration. Copyright © 2012 John Wiley & Sons, Ltd.

Strength Loss in MA-MOX Green Pellets from Radiation Damage to Binders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paul A. Lessing; W.R. Cannon; Gerald W. Egeland

The fracture strength of green Minor Actinides (MA)-MOX pellets containing 75 wt.% DUO2, 20 wt. % PuO2, 3 wt. % AmO2 and 2 wt. % NpO2 was studied as a function of storage time, after mixing in the binder and before sintering, to test the effect of radiation damage on binders. Fracture strength degraded continuously over the 10 days of the study for all three binders studied: PEG binder (Carbowax 8000), microcrystalline wax (Mobilcer X) and Styrene-acrylic copolymer (Duramax B1022) but the fracture strength of Duramax B1022 degraded the least. For instance, for several hours after mixing Carbowax 8000 withmore » MA MOX, the fracture strength of a pellet was reasonably high and pellets were easily handled without breaking but the pellets were too weak to handle after 10 days. Strength measured using diametral compression test showed strength degradation was more rapid in pellets containing 1.0 wt. % Carbowax PEG 8000 compared to those containing only 0.2 wt. %, suggesting that irradiation not only left the binder less effective but also reduced the pellet strength. In contrast the strength of pellets containing Duramax B1022 degraded very little over the 10 day period. It was suggested that the styrene portion of the Duramax B1022 copolymer provided the radiation resistance.« less

Carboxymethyl chitosan/conducting polymer as water-soluble composite binder for LiFePO4 cathode in lithium ion batteries

NASA Astrophysics Data System (ADS)

Zhong, Haoxiang; He, Aiqin; Lu, Jidian; Sun, Minghao; He, Jiarong; Zhang, Lingzhi

2016-12-01

A water-soluble conductive composite binder consisting of carboxymethyl chitosan (CCTS) as a binder and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as a conduction-promoting agent is reported for the LiFePO4 (LFP) cathode in Li-ion batteries. The introduction of conductive PEDOT:PSS as a conductive composite binder facilitates the formation of homogeneous and continuous conducting bridges throughout the electrode and raises the compaction density of the electrode sheet by decreasing the amounts of the commonly used conducting agent of acetylene black. The optimized replacement ratios of acetylene black with PEDOT:PSS (acetylene black/PEDOT:PSS = 1:1, by weight) are obtained by measuring electrical conductivity, peel strength and compaction density of the electrode sheets. The LFP half-cell with the optimized conductive binder exhibits better cycling and rate performance and more favorable electrochemical kinetics than that using only acetylene black conducting agent. The pilot application of PEDOT:PSS/CCTS binder in 10 Ah CCTS-LFP prismatic cell exhibits a comparable cycling performance, retaining 89.7% of capacity at 1 C/2 C (charge/discharge) rate as compared with 90% for commercial PVDF-LFP over 1000 cycles, and better rate capability than that of commercial PVDF-LFP, retaining 98% capacity of 1 C at 7 C rate as compared with 95.4% for PVDF-LFP.

Experimental study of the maximum resolution and packing density achievable in sintered and non-sintered binder-jet 3D printed steel microchannels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elliott, Amy M; Mehdizadeh Momen, Ayyoub; Benedict, Michael

2015-01-01

Developing high resolution 3D printed metallic microchannels is a challenge especially when there is an essential need for high packing density of the primary material. While high packing density could be achieved by heating the structure to the sintering temperature, some heat sensitive applications require other strategies to improve the packing density of primary materials. In this study the goal is to develop high green or pack densities microchannels on the scale of 2-300 microns which have a robust mechanical structure. Binder-jet 3D printing is an additive manufacturing process in which droplets of binder are deposited via inkjet into amore » bed of powder. By repeatedly spreading thin layers of powder and depositing binder into the appropriate 2D profiles, complex 3D objects can be created one layer at time. Microchannels with features on the order of 500 microns were fabricated via binder jetting of steel powder and then sintered and/or infiltrated with a secondary material. The average particle size of the steel powder was varied along with the droplet volume of the inkjet-deposited binder. The resolution of the process, packing density of the primary material, the subsequent features sizes of the microchannels, and the overall microchannel quality were characterized as a function of particle size distribution, droplet sizes and heat treatment temperatures.« less

Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder.

PubMed

Siloto, E V; Oliveira, E F A; Sartori, J R; Fascina, V B; Martins, B A B; Ledoux, D R; Rottinghaus, G E; Sartori, D R S

2013-08-01

Aflatoxins (AF) and fumonisins (FU) are a major problem faced by poultry farmers, leading to huge economic losses. This experiment was conducted to determine the effects of AF (1 mg/kg of feed) and FU (25 mg/kg of feed), singly or in combination, on the lipid metabolism in commercial layers and investigate the efficacy of a commercial binder (2 kg/t of feed) on reducing the toxic effects of these mycotoxins. A total of 168 Hisex Brown layer hens, 37 wk of age, were randomized into a 3 × 2 + 1 factorial arrangement (3 diets with no binder containing AF, FU, and AF+FU; 3 diets with binder containing AF, FU, and AF+FU; and a control diet with no mycotoxins and binders), totaling 7 treatments. The hens contaminated with AF showed the characteristic effects of aflatoxicosis, such as a yellow liver, resulting from the accumulation of liver fat, lower values of plasma very low-density lipoprotein and triglycerides, and higher relative weight of the kidneys and liver. Hepatotoxic and nephrotoxic effects of FU were not observed in this study. On the other hand, the FU caused a reduction in small intestine length and an increase in abdominal fat deposition. The glucan-based binder prevented some of the deleterious effects of these mycotoxins, particularly the effects of AF on hepatic lipid metabolism, kidney relative weight, and FU in the small intestine.