F-15B Quiet Spike(TradeMark) Aeroservoelastic Flight-Test Data Analysis

NASA Technical Reports Server (NTRS)

Kukreja, Sunil L.

2007-01-01

System identification is utilized in the aerospace community for development of simulation models for robust control law design. These models are often described as linear, time-invariant processes and assumed to be uniform throughout the flight envelope. Nevertheless, it is well known that the underlying process is inherently nonlinear. Over the past several decades the controls and biomedical communities have made great advances in developing tools for the identification of nonlin ear systems. In this report, we show the application of one such nonlinear system identification technique, structure detection, for the an alysis of Quiet Spike(TradeMark)(Gulfstream Aerospace Corporation, Savannah, Georgia) aeroservoelastic flight-test data. Structure detectio n is concerned with the selection of a subset of candidate terms that best describe the observed output. Structure computation as a tool fo r black-box modeling may be of critical importance for the development of robust, parsimonious models for the flight-test community. The ob jectives of this study are to demonstrate via analysis of Quiet Spike(TradeMark) aeroservoelastic flight-test data for several flight conditions that: linear models are inefficient for modelling aeroservoelast ic data, nonlinear identification provides a parsimonious model description whilst providing a high percent fit for cross-validated data an d the model structure and parameters vary as the flight condition is altered.

NASA's Rodent Research Project: Validation of Flight Hardware, Operations and Science Capabilities for Conducting Long Duration Experiments in Space

NASA Technical Reports Server (NTRS)

Choi, S. Y.; Beegle, J. E.; Wigley, C. L.; Pletcher, D.; Globus, R. K.

2015-01-01

Research using rodents is an essential tool for advancing biomedical research on Earth and in space. Rodent Research (RR)-1 was conducted to validate flight hardware, operations, and science capabilities that were developed at the NASA Ames Research Center. Twenty C57BL/6J adult female mice were launched on Sept 21, 2014 in a Dragon Capsule (SpaceX-4), then transferred to the ISS for a total time of 21-22 days (10 commercial mice) or 37 (10 validation mice). Tissues collected on-orbit were either rapidly frozen or preserved in RNA later at less than or equal to -80 C (n=2/group) until their return to Earth. Remaining carcasses were rapidly frozen for dissection post-flight. The three controls groups at Kennedy Space Center consisted of: Basal mice euthanized at the time of launch, Vivarium controls, housed in standard cages, and Ground Controls (GC), housed in flight hardware within an environmental chamber. FLT mice appeared more physically active on-orbit than GC, and behavior analysis are in progress. Upon return to Earth, there were no differences in body weights between FLT and GC at the end of the 37 days in space. RNA was of high quality (RIN greater than 8.5). Liver enzyme activity levels of FLT mice and all control mice were similar in magnitude to those of the samples that were optimally processed in the laboratory. Liver samples collected from the intact frozen FLT carcasses had RNA RIN of 7.27 +/- 0.52, which was lower than that of the samples processed on-orbit, but similar to those obtained from the control group intact carcasses. Nonetheless, the RNA samples from the intact carcasses were acceptable for the most demanding transcriptomic analyses. Adrenal glands, thymus and spleen (organs associated with stress response) showed no significant difference in weights between FLT and GC. Enzymatic activity was also not significantly different. Over 3,000 tissues collected from the four groups of mice have become available for the Biospecimen Sharing Program. Together, these validation flight findings demonstrate the capability to support long-duration RR on the ISS to achieve both basic science and biomedical objectives.

Creating Simulated Microgravity Patient Models

NASA Technical Reports Server (NTRS)

Hurst, Victor; Doerr, Harold K.; Bacal, Kira

2004-01-01

The Medical Operational Support Team (MOST) has been tasked by the Space and Life Sciences Directorate (SLSD) at the NASA Johnson Space Center (JSC) to integrate medical simulation into 1) medical training for ground and flight crews and into 2) evaluations of medical procedures and equipment for the International Space Station (ISS). To do this, the MOST requires patient models that represent the physiological changes observed during spaceflight. Despite the presence of physiological data collected during spaceflight, there is no defined set of parameters that illustrate or mimic a 'space normal' patient. Methods: The MOST culled space-relevant medical literature and data from clinical studies performed in microgravity environments. The areas of focus for data collection were in the fields of cardiovascular, respiratory and renal physiology. Results: The MOST developed evidence-based patient models that mimic the physiology believed to be induced by human exposure to a microgravity environment. These models have been integrated into space-relevant scenarios using a human patient simulator and ISS medical resources. Discussion: Despite the lack of a set of physiological parameters representing 'space normal,' the MOST developed space-relevant patient models that mimic microgravity-induced changes in terrestrial physiology. These models are used in clinical scenarios that will medically train flight surgeons, biomedical flight controllers (biomedical engineers; BME) and, eventually, astronaut-crew medical officers (CMO).

Time of flight imaging through scattering environments (Conference Presentation)

NASA Astrophysics Data System (ADS)

Le, Toan H.; Breitbach, Eric C.; Jackson, Jonathan A.; Velten, Andreas

2017-02-01

Light scattering is a primary obstacle to imaging in many environments. On small scales in biomedical microscopy and diffuse tomography scenarios scattering is caused by tissue. On larger scales scattering from dust and fog provide challenges to vision systems for self driving cars and naval remote imaging systems. We are developing scale models for scattering environments and investigation methods for improved imaging particularly using time of flight transient information. With the emergence of Single Photon Avalanche Diode detectors and fast semiconductor lasers, illumination and capture on picosecond timescales are becoming possible in inexpensive, compact, and robust devices. This opens up opportunities for new computational imaging techniques that make use of photon time of flight. Time of flight or range information is used in remote imaging scenarios in gated viewing and in biomedical imaging in time resolved diffuse tomography. In addition spatial filtering is popular in biomedical scenarios with structured illumination and confocal microscopy. We are presenting a combination analytical, computational, and experimental models that allow us develop and test imaging methods across scattering scenarios and scales. This framework will be used for proof of concept experiments to evaluate new computational imaging methods.

CHeCS (Crew Health Care Systems): International Space Station (ISS) Medical Hardware Catalog. Version 10.0

NASA Technical Reports Server (NTRS)

2011-01-01

The purpose of this catalog is to provide a detailed description of each piece of hardware in the Crew Health Care System (CHeCS), including subpacks associated with the hardware, and to briefly describe the interfaces between the hardware and the ISS. The primary user of this document is the Space Medicine/Medical Operations ISS Biomedical Flight Controllers (ISS BMEs).

Kaleri works with the Pilot experiment during Expedition 8

NASA Image and Video Library

2003-10-31

ISS008-E-05179 (31 October 2003) --- Cosmonaut Alexander Y. Kaleri, Expedition 8 flight engineer, works with the Russian biomedical “Pilot” experiment (MBI-15) in the Zvezda Service Module on the International Space Station (ISS). The experiment, which looks at psychological and physiological changes in crew performance during long-duration spaceflight, requires a worktable, ankle restraint system and two control handles for testing piloting skill. Kaleri represents Rosaviakosmos.

Medical Operations Support for ISS Operations - The Role of the BME Operations Team Leads

NASA Technical Reports Server (NTRS)

Janney, Rob; Sabatier, Veronica

2010-01-01

This slide presentation reviews the role of the biomedical flight controllers (BMEs), and BME Operations Team Leads (OTLs) in providing medical support for personnel on the International Space Station. This presentation will concentrate on role of the BME OTLs, who provide the integration function across the integration function across all Crew Health Care System (CHeCS) disciplines for operational products and medical procedures.

Application of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Imaging Mass Spectrometry (MALDI-TOF IMS) for Premalignant Gastrointestinal Lesions

PubMed Central

Ko, Kwang Hyun; Kwon, Chang Il; Park, So Hye; Han, Na Young; Lee, Hoo Keun; Kim, Eun Hee

2013-01-01

Imaging mass spectrometry (IMS) is currently receiving large attention from the mass spectrometric community, although its use is not yet well known in the clinic. As matrix-assisted laser desorption/ionization time-of-flight (MALDI)-IMS can show the biomolecular changes in cells as well as tissues, it can be an ideal tool for biomedical diagnostics as well as the molecular diagnosis of clinical specimens, especially aimed at the prompt detection of premalignant lesions much earlier before overt mass formation, or for obtaining histologic clues from endoscopic biopsy. Besides its use for pathologic diagnosis, MALDI-IMS is also a powerful tool for the detection and localization of drugs, proteins, and lipids in tissue. Measurement of parameters that define and control the implications, challenges, and opportunities associated with the application of IMS to biomedical tissue studies might be feasible through a deep understanding of mass spectrometry. In this focused review series, new insights into the molecular processes relevant to IMS as well as other field applications are introduced. PMID:24340253

The Application of Integrated Knowledge-based Systems for the Biomedical Risk Assessment Intelligent Network (BRAIN)

NASA Technical Reports Server (NTRS)

Loftin, Karin C.; Ly, Bebe; Webster, Laurie; Verlander, James; Taylor, Gerald R.; Riley, Gary; Culbert, Chris; Holden, Tina; Rudisill, Marianne

1993-01-01

One of NASA's goals for long duration space flight is to maintain acceptable levels of crew health, safety, and performance. One way of meeting this goal is through the Biomedical Risk Assessment Intelligent Network (BRAIN), an integrated network of both human and computer elements. The BRAIN will function as an advisor to flight surgeons by assessing the risk of in-flight biomedical problems and recommending appropriate countermeasures. This paper describes the joint effort among various NASA elements to develop BRAIN and an Infectious Disease Risk Assessment (IDRA) prototype. The implementation of this effort addresses the technological aspects of the following: (1) knowledge acquisition; (2) integration of IDRA components; (3) use of expert systems to automate the biomedical prediction process; (4) development of a user-friendly interface; and (5) integration of the IDRA prototype and Exercise Countermeasures Intelligent System (ExerCISys). Because the C Language, CLIPS (the C Language Integrated Production System), and the X-Window System were portable and easily integrated, they were chosen as the tools for the initial IDRA prototype. The feasibility was tested by developing an IDRA prototype that predicts the individual risk of influenza. The application of knowledge-based systems to risk assessment is of great market value to the medical technology industry.

Apollo Soyuz Mission: 5-Day Report

NASA Technical Reports Server (NTRS)

1975-01-01

The Apollo Soyuz Test Project mission objectives and technical investigations are summarized. Topics discussed include: spacecraft and crew systems performance; joint flight activities; scientific and applications experiments; in-flight demonstrations; biomedical considerations; and mission support performance.

National Space Biomedical Research Institute

NASA Technical Reports Server (NTRS)

2005-01-01

NSBRI partners with NASA to develop countermeasures against the deleterious effects of long duration space flight. NSBRI's science and technology projects are directed toward this goal, which is accomplished by: 1. Designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight. 2. Defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures. 3. Establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level and deliver quality medical care. 4. Transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of humankind; including the treatment of patients suffering from gravity- and radiation-related conditions on Earth. and 5. ensuring open involvement of the scientific community,industry and the public in the Institute's activities and fostering a robust collaboration with NASA, particularly through JSC.

Kennedy's Biomedical Laboratory Makes Multi-Tasking Look Easy

NASA Technical Reports Server (NTRS)

Dunn, Carol Anne

2009-01-01

If it is one thing that Florida has in abundance, it is sunshine and with that sunshine heat and humidity. For workers at the Kennedy Space Center that have to work outside in the heat and humidity, heat exhaustion/stroke is a real possibility. It might help people to know that Kennedy's Biomedical Laboratory has been testing some new Koolvests(Trademark) that can be worn underneath SCAPE suits. They have also been working on how to block out high noise levels; in fact, Don Doerr, chief of the Biomedical Lab, says, "The most enjoyable aspect is knowing that the Biomedical Lab and the skills of its employees have been used to support safe space flight, not only for the astronaut flight crew, but just as important for the ground processing personnel as well." The NASA Biomedical Laboratory has existed in the John F. Kennedy's Operations and Checkout Building since the Apollo Program. The primary mission of this laboratory has been the biomedical support to major, manned space programs that have included Apollo, Apollo-Soyuz, Skylab, and Shuttle. In this mission, the laboratory has been responsible in accomplishing much of the technical design, planning, provision, fabrication, and maintenance of flight and ground biomedical monitoring instrumentation. This includes the electronics in the launch flight suit and similar instrumentation systems in the spacecraft. (Note: The Lab checked out the system for STS-128 at Pad A using Firing room 4 and ground support equipment in the lab.) During Apollo, there were six engineers and ten technicians in the facility. This has evolved today to two NASA engineers and two NASA technicians, a Life Science Support contract physiologist and part-time support from an LSSC nurse and physician. Over the years, the lab has enjoyed collaboration with outside agencies and investigators. These have included on-site support to the Ames Research Center bed rest studies (seven years) and the European Space Agency studies in Toulouse, France (two years). The lab has also actively collaborated with the US Army Institute for Surgical Research, the USAF School of Aerospace Medicine, and the USN Naval Experimental Diving Unit. Because the lab often evaluates various forms of commercial-off-the-shelf life support equipment, the laboratory works closely with private companies, both domestic and foreign. The European companies seem to be more proactive and participatory with the advancement of personal protective equipment. Because these companies have viewed the space program's unique need for advanced forms of personal protective equipment, some have responded with new designs based on the prediction that these advances will soon find markets in the commercial sector. Using much of the same skills and equipment, the laboratory also addresses physiological testing of humans by supporting flight experiments and personnel involved with ground processing. While Johnson Space Center is primarily responsible for flight experiments, the Kennedy's Biomedical Lab provides the local support. However, as stated above, there are many challenges facing KSC workers that gain the attention of this lab in the measurement of the problem and the selection and testing of countermeasures. These include respiratory protection, whole body suits, hearing protection and heat stress, among many others.

Acquisition of a Biomedical Database of Acute Responses to Space Flight during Commercial Personal Suborbital Flights

NASA Technical Reports Server (NTRS)

Charles, John B.; Richard, Elizabeth E.

2010-01-01

There is currently too little reproducible data for a scientifically valid understanding of the initial responses of a diverse human population to weightlessness and other space flight factors. Astronauts on orbital space flights to date have been extremely healthy and fit, unlike the general human population. Data collection opportunities during the earliest phases of space flights to date, when the most dynamic responses may occur in response to abrupt transitions in acceleration loads, have been limited by operational restrictions on our ability to encumber the astronauts with even minimal monitoring instrumentation. The era of commercial personal suborbital space flights promises the availability of a large (perhaps hundreds per year), diverse population of potential participants with a vested interest in their own responses to space flight factors, and a number of flight providers interested in documenting and demonstrating the attractiveness and safety of the experience they are offering. Voluntary participation by even a fraction of the flying population in a uniform set of unobtrusive biomedical data collections would provide a database enabling statistical analyses of a variety of acute responses to a standardized space flight environment. This will benefit both the space life sciences discipline and the general state of human knowledge.

Biomedical research publications: 1980 - 1982

NASA Technical Reports Server (NTRS)

Pleasant, L. G.; Limbach, L.

1982-01-01

Publications concerning the major physiological and psychological problems encountered by man when he undertakes space flight are listed. Nine research areas are included: cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, blood cell alterations, fluid and eletrolyte changes, radiation effects and protection, behavior and performance, and general biomedical research.

John Glenn Biomedical Engineering Consortium

NASA Technical Reports Server (NTRS)

Nall, Marsha

2004-01-01

The John Glenn Biomedical Engineering Consortium is an inter-institutional research and technology development, beginning with ten projects in FY02 that are aimed at applying GRC expertise in fluid physics and sensor development with local biomedical expertise to mitigate the risks of space flight on the health, safety, and performance of astronauts. It is anticipated that several new technologies will be developed that are applicable to both medical needs in space and on earth.

Collaborative research in cardiovascular dynamics and bone elasticity

NASA Technical Reports Server (NTRS)

1974-01-01

A collaborative research program covering a variety of topics of biomechanics and biomedical engineering within the fields of cardiovascular dynamics, respiration, bone elasticity and vestibular physiology is described. The goals of the research were to promote: (1) a better understanding of the mechanical behavior of the circulatory system and its control mechanisms; (2) development of noninvasive methods of measuring the changes in the mechanical properties of blood vessels and other cardiovascular parameters in man; (3) application of these noninvasive methods to examine in man the physiological effects of environmental changes, including earth-simulated gravitational changes; and (4) development of in-flight methods for studying the events which lead to post-flight postural hypotension.

National Space Biomedical Research Institute Annual Report

NASA Technical Reports Server (NTRS)

2000-01-01

This report summarizes the activities of the National Space Biomedical Research Institute (NSBRI) during FY 2000. The NSBRI is responsible for the development of countermeasures against the deleterious effects of long-duration space flight and performs fundamental and applied space biomedical research directed towards this specific goal. Its mission is to lead a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan by focusing on the enabling of long-term human presence in, development of, and exploration of space. This is accomplished by: designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of mankind, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through NASA's Lyndon B. Johnson Space Center. Attachment:Appendices (A,B,C,D,E,F,G,H,I,J,K,L,M,N,O, and P.).

Application of Telemedicine Technologies to Long Term Spaceflight Support

NASA Astrophysics Data System (ADS)

Orlov, O. I.; Grigoriev, A. I.

Space medicine passed a long way of search for informative methods of medical data collection and analysis and worked out a complex of effective means of countermeasures and medical support. These methods and means aimed at optimization of the habitation conditions and professional activity of space crews enabled space medicine specialists to create a background for the consecutive prolongation of manned space flights and providing their safety and effectiveness. To define support systems perspectives we should consider those projects on which bases the systems are implemented. According to the set opinion manned spaceflights programs will develop in two main directions. The first one is connected with the near space exploration, first of all with the growing interest in scientific-applied and in prospect industrial employment of large size orbit manned complexes, further development of transport systems and in long-run prospect - reclamation of Lunar surface. The second direction is connected with the perspectives of interplanetary missions. There's no doubt that the priority project of the near-earth space exploration in the coming decenaries will be building up of the International Space Station. This trend characteristics prove the necessity to provide crews whose members may differ in health with individual approach to the schedule of work, rest, nutrition and training, to the medical control and therapeutic-prophylactic procedures. In these conditions the importance of remote monitoring and distance support of crew members activities by the earth- based medical control services will increase. The response efficiency in such cases can only be maintained by means of advanced telemedicine systems. The international character of the International Space Station (ISS) gives a special importance to the current activities on integrating medical support systems of the participating countries. Creation of such a system will allow to coordinate international research projects on space biology and medicine at the modern high level. In spite of the ISS international cooperation transparency space research programs require to follow the biomedicine ethics and provide confidentiality of the special medical information exchange. That can be achieved in the telemedicine support system built on the network principle. Presently we have all technical facilities needed to create such a system. In Russia activities on space telemedicicine support improvement are carried out by the State Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Mission Control Center of the Russian Aviation and Space Agency, Space Biomedical Center for Training and Research and Yu. Gagarin Cosmonaut Training Center. Communications development and next generation Internet systems creation almost eliminate differences in the types of information technologies implementation both in the earth-based and near-earth space conditions. In prospect of the information community creation the telecommunication system of the near-earth space objects and its telemedicine element will become a natural part of the Earth unified information field that will open unlimited perspectives for flight support system improvement and space biomedical research conducting. Russia has unique data of numerous investigations on simulation of long, up to a year, effects of space flight factors on the human body. The sphere of situations studied by space medicine specialists embraced orbit manned space flights of the escalating duration (438 days in 1995). However a number of biomedical problems related to space flights didn't face optimal solutions. It's evident that during a space flight to Mars biomedical problems will be much more difficult in comparison with those of the orbit flights of the same duration. The summed up factors of such flights specify a level of the total medical risk that require assessment and application of effective means lowering the risk level. The characteristics of the interplanetary flights projects make it necessary to develop a special system of telemedicine support with an accent on the onboard facilities. Space crew medical support systems must be "intellectual". The telemedicine system of the interplanetary spacecraft should be based on the extremely large data bank, it's better say "knowledge bank", i.e. it should contain the mankind medical knowledge in miniature. At the same time the system capacity is determined by the flight conditions and existing or supposed factors of the effect on the crew. It can be complemented and concretized from the Earth during the flight. Crew interaction with this system will be built on symbiotic "man-machine" combination where a man has a creative inception, adaptability, common sense and intuition, he or she is irreplaceable in situations when nonstandard decisions should be taken in conditions of time and ingoing parameters shortage. A physician's presence in the crew of the spacecraft will decrease the medical risk of the mission. It's quite natural that the effective operations of this knowledge system carried out autonomously by the crew physician or earth-based service can function only if the system is based on the artificial intelligence principles, neuro information systems with the highest degree of analytical functions and prognostical capabilities of the models. Development of telemedicine technologies will greatly change an extent and level of the interference into a crewmember organism. Interplanetary flight support telemedicine solutions present a new quality of simulation and influence systems. They're not simply a new instrument opening promising opportunities to improve flight medical support systems. They integrate information technologies with biology, physics and chemistry. It's a new interdisciplinary technological breakthrough.

Legacy of Biomedical Research During the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Hayes, Judith C.

2011-01-01

The Space Shuttle Program provided many opportunities to study the role of spaceflight on human life for over 30 years and represented the longest and largest US human spaceflight program. Outcomes of the research were understanding the effect of spaceflight on human physiology and performance, countermeasures, operational protocols, and hardware. The Shuttle flights were relatively short, < 16 days and routinely had 4 to 6 crewmembers for a total of 135 flights. Biomedical research was conducted on the Space Shuttle using various vehicle resources. Specially constructed pressurized laboratories called Spacelab and SPACEHAB housed many laboratory instruments to accomplish experiments in the Shuttle s large payload bay. In addition to these laboratory flights, nearly every mission had dedicated human life science research experiments conducted in the Shuttle middeck. Most Shuttle astronauts participated in some life sciences research experiments either as test subjects or test operators. While middeck experiments resulted in a low sample per mission compared to many Earth-based studies, this participation allowed investigators to have repetition of tests over the years on successive Shuttle flights. In addition, as a prelude to the International Space Station (ISS), NASA used the Space Shuttle as a platform for assessing future ISS hardware systems and procedures. The purpose of this panel is to provide an understanding of science integration activities required to implement Shuttle research, review biomedical research, characterize countermeasures developed for Shuttle and ISS as well as discuss lessons learned that may support commercial crew endeavors. Panel topics include research integration, cardiovascular physiology, neurosciences, skeletal muscle, and exercise physiology. Learning Objective: The panel provides an overview from the Space Shuttle Program regarding research integration, scientific results, lessons learned from biomedical research and countermeasure development.

Space motion sickness medications - Interference with biomedical parameters

NASA Technical Reports Server (NTRS)

Vernikos-Danellis, J.; Winget, C. M.; Leach, C. S.; Rosenblatt, L. S.; Lyman, J.; Beljan, J. R.

1976-01-01

The possibility that drugs administered to Skylab 3 and 4 crewmen for space motion sickness may have interfered with their biomedical evaluation in space is investigated. The mixture of scopolamine and dextroamphetamine produced changes which allow a more valid interpretation of the early biomedical changes ocurring in weightlessness. There is no doubt that the dramatic increase in aldosterone excretion is not attributable to the drug, while the drug could have contributed to the in-flight changes observed in cortisol, epinephrine, heart rate and possibly urine volume.

Biomedical Results of Apollo

NASA Technical Reports Server (NTRS)

Johnston, R. S. (Editor); Dietlein, L. F. (Editor); Berry, C. A. (Editor); Parker, James F. (Compiler); West, Vita (Compiler)

1975-01-01

The biomedical program developed for Apollo is described in detail. The findings are listed of those investigations which are conducted to assess the effects of space flight on man's physiological and functional capacities, and significant medical events in Apollo are documented. Topics discussed include crew health and inflight monitoring, preflight and postflight medical testing, inflight experiments, quarantine, and life support systems.

["Soiuz-Apollo" experimental flight. Preliminary results of medicobiological studies, carried out during the flight of "Soiuz-19" spaceship].

PubMed

Vorob'ev, E I; Gazenko, O G; Gurovskiĭ, N N; Nefedov, Iu G; Egorov, B B

1976-01-01

The paper presents brief information on the Apollo-Soyuz test mission, its program biomedical investigations to be carried out in flight and specific medical aspects. It discusses the main tasks of the joint US-USSR experiments and Soviet experiments. It gives and analyzes preliminary results of medical monitoring and postflight examinations of the crew members.

Strategic implementation plan

NASA Technical Reports Server (NTRS)

1989-01-01

The Life Science Division of the NASA Office of Space Science and Applications (OSSA) describes its plans for assuring the health, safety, and productivity of astronauts in space, and its plans for acquiring further fundamental scientific knowledge concerning space life sciences. This strategic implementation plan details OSSA's goals, objectives, and planned initiatives. The following areas of interest are identified: operational medicine; biomedical research; space biology; exobiology; biospheric research; controlled ecological life support; flight programs and advance technology development; the life sciences educational program; and earth benefits from space life sciences.

Swanson uses the BMMD in the SM

NASA Image and Video Library

2014-03-31

ISS039-E-008066 (30 March 2014) --- NASA astronaut Steve Swanson, Expedition 39 flight engineer, participates in body mass measurement/Russian biomedical routine assessments in the Zvezda Service Module of the International Space Station. Looking on is Russian cosmonaut Alexander Skvortsov, flight engineer representing the Russian Federal Space Agency (Roscosmos).

Research and technology activities at Ames Research Center's Biomedical Research Division

NASA Technical Reports Server (NTRS)

Martello, N.

1985-01-01

Various research and technology activities at Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include descriptions of research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, behavior and performance, gravitational biology, and life sciences flight experiments.

The Value of Biomedical Simulation Environments to Future Human Space Flight Missions

NASA Technical Reports Server (NTRS)

Mulugeta, Lealem; Myers, Jerry G.; Skytland, Nicholas G.; Platts, Steven H.

2010-01-01

With the ambitious goals to send manned missions to asteroids and onto Mars, substantial work will be required to ensure the well being of the men and women who will undertake these difficult missions. Unlike current International Space Station or Shuttle missions, astronauts will be required to endure long-term exposure to higher levels of radiation, isolation and reduced gravity. These new operation conditions will pose health risks that are currently not well understood and perhaps unanticipated. Therefore, it is essential to develop and apply advanced tools to predict, assess and mitigate potential hazards to astronaut health. NASA s Digital Astronaut Project (DAP) is working to develop and apply computational models of physiologic response to space flight operation conditions over various time periods and environmental circumstances. The collective application and integration of well vetted models assessing the physiology, biomechanics and anatomy is referred to as the Digital Astronaut. The Digital Astronaut simulation environment will serve as a practical working tool for use by NASA in operational activities such as the prediction of biomedical risks and functional capabilities of astronauts. In additional to space flight operation conditions, DAP s work has direct applicability to terrestrial biomedical research by providing virtual environments for hypothesis testing, experiment design, and to reduce animal/human testing. A practical application of the DA to assess pre and post flight responses to exercise is illustrated and the difficulty in matching true physiological responses is discussed.

Structure Computation of Quiet Spike[Trademark] Flight-Test Data During Envelope Expansion

NASA Technical Reports Server (NTRS)

Kukreja, Sunil L.

2008-01-01

System identification or mathematical modeling is used in the aerospace community for development of simulation models for robust control law design. These models are often described as linear time-invariant processes. Nevertheless, it is well known that the underlying process is often nonlinear. The reason for using a linear approach has been due to the lack of a proper set of tools for the identification of nonlinear systems. Over the past several decades, the controls and biomedical communities have made great advances in developing tools for the identification of nonlinear systems. These approaches are robust and readily applicable to aerospace systems. In this paper, we show the application of one such nonlinear system identification technique, structure detection, for the analysis of F-15B Quiet Spike(TradeMark) aeroservoelastic flight-test data. Structure detection is concerned with the selection of a subset of candidate terms that best describe the observed output. This is a necessary procedure to compute an efficient system description that may afford greater insight into the functionality of the system or a simpler controller design. Structure computation as a tool for black-box modeling may be of critical importance for the development of robust parsimonious models for the flight-test community. Moreover, this approach may lead to efficient strategies for rapid envelope expansion, which may save significant development time and costs. The objectives of this study are to demonstrate via analysis of F-15B Quiet Spike aeroservoelastic flight-test data for several flight conditions that 1) linear models are inefficient for modeling aeroservoelastic data, 2) nonlinear identification provides a parsimonious model description while providing a high percent fit for cross-validated data, and 3) the model structure and parameters vary as the flight condition is altered.

Estimating the Effects of Astronaut Career Ionizing Radiation Dose Limits on Manned Interplanetary Flight Programs

NASA Technical Reports Server (NTRS)

Koontz, Steven L.; Rojdev, Kristina; Valle, Gerard D.; Zipay, John J.; Atwell, William S.

2013-01-01

The Hybrid Inflatable DSH combined with electric propulsion and high power solar-electric power systems offer a near TRL-now solution to the space radiation crew dose problem that is an inevitable aspect of long term manned interplanetary flight. Spreading program development and launch costs over several years can lead to a spending plan that fits with NASA's current and future budgetary limitations, enabling early manned interplanetary operations with space radiation dose control, in the near future while biomedical research, nuclear electric propulsion and active shielding research and development proceed in parallel. Furthermore, future work should encompass laboratory validation of HZETRN calculations, as previous laboratory investigations have not considered large shielding thicknesses and the calculations presented at these thicknesses are currently performed via extrapolation.

Phase shifts of the human circadian system and performance deficit during the periods of transition : I, East-West flight.

DOT National Transportation Integrated Search

1965-12-01

At periodic intervals throughout the biological day, biomedical assessments were made for a week prior to jet flight to Santiago, Chile, for 12 days at Santiago, and for a week following return to Washington, D.C. Although previous East-West and West...

Phase shifts of the human circadian system and performance deficit during the periods of transition : II, West-East flight.

DOT National Transportation Integrated Search

1965-12-01

At periodic intervals throughout the biological day, biomedical assessments were made for a week prior to jet flight to Rome, for 12 days at Rome, and for a week following return to Oklahoma City. A primary shift of circadian periodicity was manifest...

Phase shifts of the human circadian system and performance deficit during the periods of transition : III, North-South flight.

DOT National Transportation Integrated Search

1965-12-01

At periodic intervals throughout the biological day, biomedical assessments were made for a week prior to jet flight to Santiago, Chile, for 12 days at Santiago, and for a week following return to Washington, D.C. Although previous East-West and West...

Animals in biomedical space research

NASA Astrophysics Data System (ADS)

Phillips, Robert W.

The use of experimental animals has been a major component of biomedical research progress. Using animals in space presents special problems, but also provides special opportunities. Rat and squirrel monkeys experiments have been planned in concert with human experiments to help answer fundamental questions concerning the effect of weightlessness on mammalian function. For the most part, these experiments focus on identified changes noted in humans during space flight. Utilizing space laboratory facilities, manipulative experiments can be completed while animals are still in orbit. Other experiments are designed to study changes in gravity receptor structure and function and the effect of weightlessness on early vertebrate development. Following these preliminary animals experiments on Spacelab Shuttle flights, longer term programs of animal investigation will be conducted on Space Station.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradshaw, Nathan P.; Severt, Sean Y.; Wang, Zhaoying

Biocompatible materials capable of controlled actuation under biologically relevant conditions are in high demand for use in a number of biomedical applications. Recently, we demonstrated that a composite material composed of silk biopolymer and the conducting polymer poly(pyrrole) can bend under an applied voltage using a simple bilayer device. Here we present further characterization of these bilayer actuators using time of flight secondary ion mass spectrometry, and provide clarification on the mechanism of actuation and factors affecting device performance and stability. We will discuss the results of this study in the context of strategies for optimization of device performance.

Space motion sickness: The sensory motor controls and cardiovascular correlation

NASA Astrophysics Data System (ADS)

Souvestre, Philippe A.; Blaber, Andrew P.; Landrock, Clinton K.

Background and PurposeSpace motion sickness (SMS) and related symptoms remain a major limiting factor in Space operations. A recent comprehensive literature review [J.R. Lackner, Z. DiZio, Space motion sickness, Experimental Brain Research 175 (2006) 377-399, doi 10.1007/s00221-006-0697-y] concluded that SMS does not represent a unique diagnostic entity, and there is no adequate predictor of SMS' susceptibility and severity. No countermeasure has been found reliable to prevent or treat SMS symptoms onset. Recent neurophysiological findings on sensory-motor controls monitoring [P.A. Souvestre, C. Landrock, Biomedical-performance monitoring and assessment of astronauts by means of an ocular vestibular monitoring system, Acta Astronautica, 60 (4-7) (2007) 313-321, doi:10.1016/j.actaastro.2006.08.013] and heart-rate variability (HRV) measurements relationship could explain post-flight orthostatic intolerance (PFOI) in astronauts [A.P. Blaber, R.L. Bondar, M.S. Kassam, Heart rate variability and short duration space flight: relationship to post-flight orthostatic intolerance, BMC Physiology 4 (2004) 6]. These two methodologies are generally overlooked in SMS' analysis. In this paper we present the case for a strong relationship between sensory-motor controls related symptoms, including orthostatic intolerance (OI) and SMS symptoms. MethodsThis paper expands on several previously published papers [J.R. Lackner, Z. DiZio, Space motion sickness, Experimental Brain Research 175 (2006) 377-399, doi 10.1007/s00221-006-0697-y; P.A. Souvestre, C. Landrock, Biomedical-performance monitoring and assessment of astronauts by means of an ocular vestibular monitoring system, Acta Astronautica, 60 (4-7) (2007) 313-321, doi:10.1016/j.actaastro.2006.08.013] along with an updated literature review. An analysis of a 10-year period clinical data from trauma patients experiencing postural deficiency syndrome (PDS) show assessment and monitoring techniques which successfully identify trauma impacts on core regulatory sensory motor and cognitive mechanisms. Static postural analysis provides specific central neurophysiological markers that can reliably identify PDS occurrence among classic peripheral musculoskeletal and spinal data [C. Landrock, P.A. Souvestre, Static postural analysis: a methodology to assess gravity related sensory motor controls' status for astronauts, 2006-01-2298, 36th SAE-ICES]. Many astronauts experience PFOI and recent research has implicated altered autonomic cardiovascular regulation caused by microgravity. HRV measurements have been used to determine if some pre-flight autonomic indicators relating to PFOI may exist by differentiating parasympathetic and sympathetic activity. ResultsThis review suggests a new approach to SMS mitigation based on specific neurophysiological assessment criteria. While SMS may not be a "unique diagnosis", it should be treated as result, or symptom of, the condition space adaptation syndrome (SAS), which can be shown to be a unique diagnosis. This methodology can identify and measure brain functional status in specific areas during pre-flight and post-flight examinations. This could provide further understanding on why, how and when SMS and PFOI might occur in Astronauts, and lead to criteria that predict susceptibility to SMS. An additional test component is presented that relates to using static central sensory-motor data towards understanding SMS and OI occurrence. Recent investigations indicate relationship between HRV autonomic indicators with Motion Sickness [B. Cheung, K. Hoffer, R. Heskin, A. Smith, Physiological and behavioral responses to an exposure to pitch illusion in the simulator, Aviation Space, 2004; Y. Yokota, M. Aoki, K. Mizuta, Y. Ito, N. Isu, Motion sickness susceptibility associated with visually induced postural instability and cardiac autonomic responses in healthy subjects, Acta Oto-laryngological, 2005]. It is found that astronauts with lower sympatho-vagal balance and higher supine parasympathetic activity pre-flight may present with PFOI indicators. Not only HRV provides information on autonomic regulation, but HRV pattern appears to be chaotic and/or fractal. Beat-by-beat HRV yields fractal dimension of the cardiovascular control system [C.K. Peng, J. Mistus, J.M. Hausdorff, S. Havlin, H.E. Stanley, A.L. Goldberger, Long-range anticorrelations and non-Gaussian behavior of the heartbeat, Physics Review Letters 70 (1999) 1343-1346]. Similar properties can be found in other physiological signals such as breathing intervals and gait pattern [N. Scafetta, R. Moon, B.J. West, Physiological signals and their fractal response to stress conditions, environmental changes and neurodegenerative diseases, in: Proceedings of The 25th Army Science Conference (ASC), Orlando, Florida, November 27-30, 2006]. ConclusionsA strong correlation between unmitigated SMS and PFOI related symptoms in astronauts has been presented. There is also strong correlation with PDS related symptoms, which can be accurately identified, measured, and monitored via a specific ocular-vestibular-postural monitoring system along with relevant clinical data. Along with the associated autonomic interactions detected by HRV, the fractal nature of the HRV data may provide useful information on the nature and complexity of central neural controls in relation to physiological [A.P. Blaber, R.L. Bondar, R. Freeman, Coarse grained spectral analysis of HR and BP variability in patients with autonomic failure, American Journal of Physiology 271 (1996) H1555-H1564] and mental stress [Y. Hoshikawa, Y. Yamamoto, Effects of Stroop color-word conflict test on the autonomic nervous system responses, American Journal of Physiology, 1997]. The data presented provide strong evidence that proper biomedical assessment methodologies employed with appropriate technology can lead to better understanding Astronauts' pre-flight and post-flight biomedical status, necessary to further human exploration in Space on a safe and successful path.

Materials processing in space

NASA Technical Reports Server (NTRS)

1975-01-01

The feasibility and possible advantages of processing materials in a nongravitational field are considered. Areas of investigation include biomedical applications, the processing of inorganic materials, and flight programs and funding.

Space transportation system biomedical operations support study

NASA Technical Reports Server (NTRS)

White, S. C.

1983-01-01

The shift of the Space Transportation System (STS) flight tests of the orbiter vehicle to the preparation and flight of the payloads is discussed. Part of this change is the transition of the medical and life sciences aspects of the STS flight operations to reflect the new state. The medical operations, the life sciences flight experiments support requirements and the intramural research program expected to be at KSC during the operational flight period of the STS and a future space station are analyzed. The adequacy of available facilities, plans, and resources against these future needs are compared; revisions and/or alternatives where appropriate are proposed.

F-15B QuietSpike(TradeMark) Aeroservoelastic Flight Test Data Analysis

NASA Technical Reports Server (NTRS)

Kukreja, Sunil L.

2007-01-01

System identification or mathematical modelling is utilised in the aerospace community for the development of simulation models for robust control law design. These models are often described as linear, time-invariant processes and assumed to be uniform throughout the flight envelope. Nevertheless, it is well known that the underlying process is inherently nonlinear. The reason for utilising a linear approach has been due to the lack of a proper set of tools for the identification of nonlinear systems. Over the past several decades the controls and biomedical communities have made great advances in developing tools for the identification of nonlinear systems. These approaches are robust and readily applicable to aerospace systems. In this paper, we show the application of one such nonlinear system identification technique, structure detection, for the analysis of F-15B QuietSpike(TradeMark) aeroservoelastic flight test data. Structure detection is concerned with the selection of a subset of candidate terms that best describe the observed output. This is a necessary procedure to compute an efficient system description which may afford greater insight into the functionality of the system or a simpler controller design. Structure computation as a tool for black-box modelling may be of critical importance for the development of robust, parsimonious models for the flight-test community. Moreover, this approach may lead to efficient strategies for rapid envelope expansion which may save significant development time and costs. The objectives of this study are to demonstrate via analysis of F-15B QuietSpike(TradeMark) aeroservoelastic flight test data for several flight conditions (Mach number) that (i) linear models are inefficient for modelling aeroservoelastic data, (ii) nonlinear identification provides a parsimonious model description whilst providing a high percent fit for cross-validated data and (iii) the model structure and parameters vary as the flight condition is altered.

Spaceflight Decompression Sickness Contingency Plan

NASA Technical Reports Server (NTRS)

Dervay, Joseph P.

2007-01-01

A viewgraph presentation on the Decompression Sickness (DCS) Contingency Plan for manned spaceflight is shown. The topics include: 1) Approach; 2) DCS Contingency Plan Overview; 3) Extravehicular Activity (EVA) Cuff Classifications; 4) On-orbit Treatment Philosophy; 5) Long Form Malfunction Procedure (MAL); 6) Medical Checklist; 7) Flight Rules; 8) Crew Training; 9) Flight Surgeon / Biomedical Engineer (BME) Training; and 10) DCS Emergency Landing Site.

Advanced flight hardware for organic separations using aqueous two-phase partitioning

NASA Astrophysics Data System (ADS)

Deuser, Mark S.; Vellinger, John C.; Weber, John T.

1996-03-01

Separation of cells and cell components is the limiting factor in many biomedical research and pharmaceutical development processes. Aqueous Two-Phase Partitioning (ATPP) is a unique separation technique which allows purification and classification of biological materials. SHOT has employed the ATPP process in separation equipment developed for both space and ground applications. Initial equipment development and research focused on the ORganic SEParation (ORSEP) space flight experiments that were performed on suborbital rockets and the shuttle. ADvanced SEParations (ADSEP) technology was developed as the next generation of ORSEP equipment through a NASA Small Business Innovation Research (SBIR) contract. Under the SBIR contract, a marketing study was conducted, indicating a growing commercial market exists among biotechnology firms for ADSEP equipment and associated flight research and development services. SHOT is preparing to begin manufacturing and marketing laboratory versions of the ADSEP hardware for the ground-based market. In addition, through a self-financed SBIR Phase III effort, SHOT is fabricating and integrating the ADSEP flight hardware for a commercially-driven SPACEHAB 04 experiment that will be the initial step in marketing space separations services. The ADSEP ground-based and microgravity research is expected to play a vital role in developing important new biomedical and pharmaceutical products.

Commercial Instrumentation Technology Associates' Biomedical Experiments

NASA Technical Reports Server (NTRS)

2003-01-01

Experiments to seek solutions for a range of biomedical issues are at the heart of several investigations that will be hosted by the Commercial Instrumentation Technology Associates (ITA), Inc. Biomedical Experiments (CIBX-2) payload. CIBX-2 is unique, encompassing more than 20 separate experiments including cancer research, commercial experiments, and student hands-on experiments from 10 schools as part of ITA's ongoing University Among the Stars program. Student Marnix Aklian and ITA's Mark Bem prepare biological samples for flight as part of ITA's hands-on student outreach program on STS-95. Similar activities are a part of the CIBX-2 payload. The experiments are sponsored by NASA's Space Product Development Program (SPD).

Advances in Rodent Research Missions on the International Space Station

NASA Technical Reports Server (NTRS)

Choi, S. Y.; Ronca, A.; Leveson-Gower, D.; Gong, C.; Stube, K.; Pletcher, D.; Wigley, C.; Beegle, J.; Globus, R. K.

2016-01-01

A research platform for rodent experiment on the ISS is a valuable tool for advancing biomedical research in space. Capabilities offered by the Rodent Research project developed at NASA Ames Research Center can support experiments of much longer duration on the ISS than previous experiments performed on the Space Shuttle. NASAs Rodent Research (RR)-1 mission was completed successfully and achieved a number of objectives, including validation of flight hardware, on-orbit operations, and science capabilities as well as support of a CASIS-sponsored experiment (Novartis) on muscle atrophy. Twenty C57BL6J adult female mice were launched on the Space-X (SpX) 4 Dragon vehicle, and thrived for up to 37 days in microgravity. Daily health checks of the mice were performed during the mission via downlinked video; all flight animals were healthy and displayed normal behavior, and higher levels of physical activity compared to ground controls. Behavioral analysis demonstrated that Flight and Ground Control mice exhibited the same range of behaviors, including eating, drinking, exploratory behavior, self- and allo-grooming, and social interactions indicative of healthy animals. The animals were euthanized on-orbit and select tissues were collected from some of the mice on orbit to assess the long-term sample storage capabilities of the ISS. In general, the data obtained from the flight mice were comparable to those from the three groups of control mice (baseline, vivarium and ground controls, which were housed in flight hardware), showing that the ISS has adequate capability to support long-duration rodent experiments. The team recovered 35 tissues from 40 RR-1 frozen carcasses, yielding 3300 aliquots of tissues to distribute to the scientific community in the U.S., including NASAs GeneLab project and scientists via Space Biology's Biospecimen Sharing Program Ames Life Science Data Archive. Tissues also were distributed to Russian research colleagues at the Institute for Biomedical Problems. The expression levels of select genes including albumin, catalase, GAPDH, HMGCoA Reductase, and IGF1 were determined using RNA isolated from the livers by qPCR and no significant differences by one factor ANOVA were found between flight and ground control groups. In addition, some of the liver samples were analyzed for transcriptomic, epigenomic and proteomic profiles; some of the data sets are now available to the scientific community through GeneLabs open science data website. A second long duration mission, Rodent Research-2 (RR-2) was completed on the ISS in 2015; 20 female C57BL6J mice were successfully maintained on the ISS for various durations, with the last group of 5 animals living on-orbit for 54 days. Furthermore, we continue to expand the ISSs capabilities by introducing new on-orbit technologies including blood collection and separation, bone densitometry scanning, muscle grip strength and anesthesia with recovery. In addition, series of ground-based verification testing to fly male mice and increase the total number of mice on-orbit from 20 to 40. Subsequent missions will provide the capability to return live mice from the ISS animals to evaluate recovery on Earth, further expanding operational and science capabilities of the RR project on the ISS.

Performance Support Tools for Space Medical Operations

NASA Technical Reports Server (NTRS)

Byrne, Vicky; Schmid, Josef; Barshi, Immanuel

2010-01-01

Early Constellation space missions are expected to have medical capabilities similar to those currently on board the Space Shuttle and International Space Station (ISS). Flight surgeons on the ground in Mission Control will direct the Crew Medical Officer (CMO) during medical situations. If the crew is unable to communicate with the ground, the CMO will carry out medical procedures without the aid of a flight surgeon. In these situations, use of performance support tools can reduce errors and time to perform emergency medical tasks. The research presented here is part of the Human Factors in Training Directed Research Project of the Space Human Factors Engineering Project under the Space Human Factors and Habitability Element of the Human Research Program. This is a joint project consisting of human factors teams from the Johnson Space Center (JSC) and the Ames Research Center (ARC). Work on medical training has been conducted in collaboration with the Medical Training Group at JSC and with Wyle that provides medical training to crew members, biomedical engineers (BMEs), and flight surgeons under the Bioastronautics contract. Human factors personnel at Johnson Space Center have investigated medical performance support tools for CMOs and flight surgeons.

Life Sciences Research and Development Opportunities During Suborbital Space Flight

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2010-01-01

Suborbital space platforms provide a unique opportunity for Space Life Sciences in the next few years. The opportunities include: physiological characterization of the first few minutes of space flight; evaluation of a wide-variety of medical conditions during periods of hyper and hypo-gravity through physiological monitoring; and evaluation of new biomedical and environmental health technologies under hyper and hypo-gravity conditions

Physiologic and anti-G suit performance data from YF-16 flight tests

NASA Technical Reports Server (NTRS)

Gillingham, K. K.; Winter, W. R.

1976-01-01

Biomedical data were collected during high-G portions of 11 YF-16 test flights. Test pilots monitored revealed increased respiratory rate and volume, decreased tidal volume, and increased heart rate at higher G levels, with one pilot exhibiting various cardiac arrhythmias. Anti-G suit inflation and pressurization lags varied inversely with G-onset rate, and suit pressurization slope was near the design value.

Clothing and personal hygiene

NASA Technical Reports Server (NTRS)

Finogenov, A. M.; Azhayev, A. N.; Kaliberdin, G. V.

1975-01-01

The biomedical maintenance of astronauts is discussed in terms of personal hygiene. Principal characteristics and general requirements are described which must be followed in perfecting a system of hygienic practices and in devising means to maintain personal hygiene, flight clothing, underwear, bedding, and medical-domestic equipment for manned space flights of varying durations. Factors discussed include: disposable clothing, thermal protection, oral hygiene, cleansing of the skin, and grooming of the hair.

KSC-05PD-0369

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, workers prepare the Human Research Facility-2 (HRF-2) science rack for installation into the Multi-Purpose Logistics Module Raffaello for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0372

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, the Rack Insertion Device moves the Human Research Facility-2 (HRF-2) science rack toward the Multi-Purpose Logistics Module Raffaello (at left) for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0368

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, the Human Research Facility-2 (HRF-2) science rack sits on a stand waiting to be installed into the Multi-Purpose Logistics Module Raffaello for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

National Space Biomedical Research Institute

NASA Technical Reports Server (NTRS)

1998-01-01

The National Space Biomedical Research Institute (NSBRI) sponsors and performs fundamental and applied space biomedical research with the mission of leading a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan. It focuses on the enabling of long-term human presence in, development of, and exploration of space. This will be accomplished by: designing, implementing, and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the benefit of mankind in space and on Earth, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry, and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through Johnson Space Center.

The immune system in space and microgravity

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald

2002-01-01

Space flight and models that created conditions similar to those that occur during space flight have been shown to affect a variety of immunological responses. These have primarily been cell-mediated immune responses including leukocyte proliferation, cytokine production, and leukocyte subset distribution. The mechanisms and biomedical consequences of these changes remain to be established. Among the possible causes of space flight-induced alterations in immune responses are exposure to microgravity, exposure to stress, exposure to radiation, and many more as yet undetermined causes. This review chronicles the known effects of space flight on the immune system and explores the possible role of stress in contributing to these changes.

The 2013 German-Russian BION-M1 Joint Flight Project: Skeletal Muscle and Neuromuscular Changes in Mice Housed for 30 Days in a Biosatellite on Orbit

NASA Astrophysics Data System (ADS)

Blottner, Dieter; Shenkman, Boris; Salanova, Michele

Exposure to microgravity results in various structural, biochemical and molecular changes of the skeletal neuromuscular system. The BION Joint Flight Proposal between the Charité Berlin Center of Space Medicine (www.zwmb.de) in Berlin, and the Institute of Biomedical Problem (IMBP) in Moscow, provided an exciting opportunity for a more detailed analysis of neuromuscular changes in mice (C57/bl6) exposed to real microgravity housed for 30 days in a BION M1 biosatellite on orbit. The mice from the BION flight group (n=5) were compared to three different on-ground control groups (Flight control, BION-ground and Vivarium, each n=5 mice). We started to analyse various skeletal muscles from the hind limbs or trunk. Apart from routine structural and biochemical analysis (fiber size and type distribution, slow/fastMyHC) we test the hypothesis for the presence of a microgravity-induced sarcolemma-cytosolic protein shift of nitric oxide synthase (NOS) and partial loss in neuromuscular synapse scaffold protein (Homer) immunoexpression known to be prone to disuse in mice or humans (hind limb unloading, bed rest) as previously shown (Sandonà D et al., PLoS One, 2012, Salanova M et al., FASEB J, 2011). National Sponsors: Federal Ministry of Economics and Technology (BMWi) via the German AeroSpace Board, DLR e.V., Bonn-Oberkassel, Germany (#50WB1121); Contract RAS-IMBP/Charité Berlin # Bion-M1/2013

Launch of Mercury-Redstone vehicle 2 on Jan. 21, 1961

NASA Image and Video Library

1961-08-10

S61-01942 (31 Jan. 1961) --- Launch of the Mercury-Redstone 2 (MR-2) vehicle on Jan. 31, 1961. The 16-minute suborbital flight carried biomedical test subject chimpanzee (Ham) aboard. Photo credit: NASA

KSC-05PD-0371

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, the Human Research Facility-2 (HRF-2) science rack is attached to the Rack Insertion Device that will install it into the Multi-Purpose Logistics Module Raffaello (at left) for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0374

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, a worker watches as the Rack Insertion Device slowly moves the Human Research Facility-2 (HRF-2) science rack into the Multi-Purpose Logistics Module Raffaello for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0370

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, workers prepare to attach the Human Research Facility-2 (HRF-2) science rack onto the Rack Insertion Device. HRF-2 will be installed into the Multi-Purpose Logistics Module Raffaello (at left) for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0373

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, a worker stands by as the Rack Insertion Device slowly moves the Human Research Facility-2 (HRF-2) science rack into the Multi-Purpose Logistics Module Raffaello for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

Assessment of the efficacy of medical countermeasures in space flight

NASA Technical Reports Server (NTRS)

Nicogossian, A. E.; Sulzman, F.; Radtke, M.; Bungo, M.

1989-01-01

Changes in body fluids, electrolytes, and muscle mass are manifestations of adaptation to space flight and readaptation to the 1-g environment. The purposes of this paper are to review the current knowledge of biomedical responses to short- and long-duration space missions and to assess the efficacy of countermeasures to 1-g conditioning. Exercise protocols, fluid hydration, dietary and potential pharmacologic measures are evaluated, and directions for future research activities are recommended.

Assessment of the efficacy of medical countermeasures in space flight

NASA Technical Reports Server (NTRS)

Nicogossian, A.; Sulzman, F.; Radtke, M.; Bungo, M.

1988-01-01

Changes in body fluids, electrolytes, and muscle mass are manifestations of adaptation to space flight and readaptation to the 1-g environment. The purposes of this paper are to review the current knowledge of biomedical responses to short- and long-duration space missions and to assess the efficacy of countermeasures to 1-g conditioning. Exercise protocols, fluid hydration, dietary and potential pharmacologic measures are evaluated, and directions for future research activities are recommended.

[The contribution of military aviation and space medicine to the biomedical support of the first flight into space].

PubMed

Belevitin, A B; Bukhtiiarov, I V; Zhdan'ko, I M; Bednenko, V S; Khomenko, M N

2011-04-01

April 12, 2011 Humanity celebrated 50 years of one of the greatest achievements of the twentieth century--the legendary flight of Y. Gagarin into space. In this study are highlighted the role and importance of military aviation and space medicine, and in particular, the State Scientific Research Testing Institute of Aviation and Space Medicine, Ministry of Defence of the USSR (now--the State Scientific Research Testing Institute of Military Medicine, Military Medical Academy named after S.M. Kirov) in the preparation and conduct of flight of Yu.A.Gagarin.

The space shuttle payload planning working groups. Volume 4: Life sciences

NASA Technical Reports Server (NTRS)

1973-01-01

The findings of the Life Sciences working group of the space shuttle payload planning activity are presented. The objectives of the Life Sciences investigations are: (1) to continue the research directed at understanding the origin of life and the search for extraterrestrial evidence of life, (2) biomedical research to understand mechanisms and provide criteria for support of manned flight, (3) technology development for life support, protective systems, and work aids for providing environmental control, and (4) to study basic biological functions at all levels or organization influenced by gravity, radiation, and circadian rhythms. Examples of candidate experimental schedules and the experimental package functional requirements are included.

Biomedical technical transfer. Applications of NASA science and technology

NASA Technical Reports Server (NTRS)

1976-01-01

Lower body negative pressure testing in cardiac patients has been completed as well as the design and construction of a new leg negative unit for evaluating heart patients. This technology is based on NASA research, using vacuum chambers to stress the cardiovascular system during space flight. Additional laboratory tests of an intracranial pressure transducer, have been conducted. Three new biomedical problems to which NASA technology is applicable are also identified. These are: a communication device for the speech impaired, the NASA development liquid-cooled garment, and miniature force transducers for heart research.

Pilot fatigue : intercontinental jet flight. 1. Oklahoma City Tokyo.

DOT National Transportation Integrated Search

1965-03-01

Following 3 consecutive days of biomedical assessment in Oklahoma City, six healthy subjects were transported to Tokyo, where assessments were made on alternate days throughout a period of 10 days, and were then transported back to Oklahoma City, whe...

Hypogravity Research and Educational Parabolic Flight Activities Conducted in Barcelona: a new Hub of Innovation in Europe

NASA Astrophysics Data System (ADS)

Perez-Poch, Antoni; González, Daniel Ventura; López, David

2016-12-01

We report on different research and educational activities related to parabolic flights conducted in Barcelona since 2008. We use a CAP10B single-engine aerobatic aircraft flying out of Sabadell Airport and operating in visual flight conditions providing up to 8 seconds of hypogravity for each parabola. Aside from biomedical experiments being conducted, different student teams have flown in parabolic flights in the framework of the international contest `Barcelona Zero-G Challenge', and have published their results in relevant symposiums and scientific journals. The platform can certainly be a good testbed for a proof-of-concept before accessing other microgravity platforms, and has proved to be excellent for motivational student campaigns.

The BIMDA shuttle flight mission: a low cost microgravity payload.

PubMed

Holemans, J; Cassanto, J M; Moller, T W; Cassanto, V A; Rose, A; Luttges, M; Morrison, D; Todd, P; Stewart, R; Korszun, R Z; Deardorff, G

1991-01-01

This paper presents the design, operation and experiment protocol of the Bioserve sponsored flights of the ITA Materials Dispersion Apparatus Payload (BIMDA) flown on the Space Shuttle on STS-37. The BIMDA payload represents a joint effort between ITA (Instrumentation Technology Associates, Inc.) and Bioserve Space Technologies, a NASA Center for the Commercial Development of Space, to investigate the methods and commercial potential of biomedical and fluid science applications in the microgravity environment of space. The BIMDA payload, flown in a Refrigerator/Incubator Module (R/IM) in the Orbiter middeck, consists of three different devices designed to mix fluids in space; four Materials Dispersion Apparatus (MDA) Minilabs developed by ITA, six Cell Syringes, and six Bioprocessing Modules both developed by NASA JSC and Bioserve. The BIMDA design and operation reflect user needs for late access prior to launch (<24 h) and early access after landing (<2 h). The environment for the payload is temperature controlled by the R/IM. The astronaut crew operates the payload and documents its operation. The temperature of the payload is recorded automatically during flight. The flight of the BIMDA payload is the first of two development flights of the MDA on the Space Shuttle. Future commercial flights of ITA's Materials Dispersion Apparatus on the Shuttle will be sponsored by NASA's Office of Commercial Programs and will take place over the next three years. Experiments for the BIMDA payload include research into the following areas: protein crystal growth, thin film membrane casting, collagen formation, fibrin clot formation, seed germination, enzymatic catalysis, zeolite crystallization, studies of mixing effects of lymphocyte functions, and solute diffusion and transport.

Microgravity

NASA Image and Video Library

2000-01-31

Arn Harris Hoover of Lockheed Martin Company demonstrates an engineering mockup of the Human Research Facility (HRF) that will be installed in Destiny, the U.S. Laboratory Module on the International Space Station (ISS). Using facilities similar to research hardware available in laboratories on Earth, the HRF will enable systematic study of cardiovascular, musculoskeletal, neurosensory, pulmonary, radiation, and regulatory physiology to determine biomedical changes resulting from space flight. Research results obtained using this facility are relevant to the health and the performance of the astronaut as well as future exploration of space. Because this is a mockup, the actual flight hardware may vary as desings are refined. (Credit: NASA/Marshall Space Flight Center)

Mercury Project

NASA Image and Video Library

1960-01-21

The Little Joe launch vehicle for the LJ1 mission on the launch pad at the wallops Flight Facility, Wallops Island, Virginia, on January 21, 1960. This mission achieved the suborbital Mercury cupsule test, testing of the escape system, and biomedical tests by using a monkey, named Miss Sam.

Potable water supply in U.S. manned space missions

NASA Technical Reports Server (NTRS)

Sauer, Richard L.; Straub, John E., II

1992-01-01

A historical review of potable water supply systems used in the U.S. manned flight program is presented. This review provides a general understanding of the unusual challenges these systems have presented to the designers and operators of the related flight hardware. The presentation concludes with the projection of how water supply should be provided in future space missions - extended duration earth-orbital and interplanetary missions and lunar and Mars habitation bases - and the challenges to the biomedical community that providing these systems can present.

Facilities for Biological Research Aboard the International Space Station

NASA Technical Reports Server (NTRS)

Souza, Kenneth A.; Yost, Bruce D.; Berry, William E.; Johnson, Catherine C.

1996-01-01

A centrifuge designed as part of an integrated biological facility for installation onboard the International Space Station is presented. The requirements for the 2.5 m diameter centrifuge, which is designed for the support of biological experiments are discussed. The scientific objectives of the facility are to: provide a means of conducting fundamental studies in which gravitational acceleration is a controllable variable; provide a 1g control; determine the threshold acceleration for physiological response, and determine the value of centrifugation as a potential countermeasure for the biomedical problems associated with space flight. The implementation of the facility is reported on, and the following aspects of the facility are described: the host resources systems supply requirements such as power and data control; the habitat holding rack; the life sciences glove box; the centrifuge; the different habitats for cell culture, aquatic studies, plant research and insect research; the egg incubator, and the laboratory support equipment.

Space Medicine: A Surgeon's Perspective

NASA Technical Reports Server (NTRS)

Dawson, David L.

1999-01-01

For the first four decades of human space flight NASA's priorities in life sciences and medical programs have been preventative medicine (astronaut selection and training); assessment of the physiologic effects of microgravity and other unique aspects of space flight, implementation of countermeasures to protect against adverse effects, and amelioration of these adverse effects. Because most of the U.S. space flight experience has been on short duration missions, the need for medical and diagnostic treatment capabilities have been limited.The first long-term crews will arrive on the International Space Station (ISS) in early 2000. This will usher in a new era, an era of sustained human presence in Low Earth Orbit. One of the principal purposes of the ISS program is to increase the knowledge of the effects of long duration space flight on humans, a pre-requisite to future exploration class missions beyond Low Earth Orbit (e.g., a return to the Moon or an exploration of Mars). Areas of particular interest include protection from radiation, muscle atrophy, bone loss, cardiovascular alterations, immune dysfunction, adverse psychological response to hazards and confinement, and neurovestibular alterations. In addition, long duration space flight requires the development of autonomous medical care capabilities, as the distances involved eliminate the possibility of real-time telemedicine or robotic intervention, and prevent a mission abort and a rapid return to Earth. The objectives of this presentation include: 1. A description of the International Space Station project, including its research facilities and on-orbit medical capabilities; 2. An overview of the physiological and medical problems associated with microgravity in space flight; 3. A review of NASA's biomedical research priorities and ongoing work to develop clinical care capabilities for space flight crews (including surgical interventions) and; 4. An overview of current and proposed research priorities for NASA Research Announcements, NASA Space Biomedical Research Institute, Small Business Innovation Research Grant, and other funding sources.

Long term flight electrodes

NASA Technical Reports Server (NTRS)

Mosier, B.

1975-01-01

The reproducibility, stability, and methods of preparation for the various types and forms of biomedical electrodes are discussed. A critical and selective compilation of information on biological and/or physiological electrodes is presented. A discussion of plant hydrocolloids, clays, hydrophyllic colloids, synthetic waxes, and acrylic polymers is included.

Noguchi uses BMMD in SM

NASA Image and Video Library

2010-05-26

ISS023-E-052104 (26 May 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 23 flight engineer, uses the IM mass measurement device to perform the PZEh-MO-8/Body Mass Measurement Russian biomedical routine assessments in the Zvezda Service Module of the International Space Station.

Human Adaptation to Space: Space Physiology and Countermeasures

NASA Technical Reports Server (NTRS)

Fogarty, Jennifer

2009-01-01

This viewgraph presentation reviews human physiological responses to spaceflight, and the countermeasures taken to prevent adverse effects of manned space flight. The topics include: 1) Human Spaceflight Experience; 2) Human Response to Spaceflight; 3) ISS Expeditions 1-16; 4) Countermeasure; and 5) Biomedical Data;

Space Flight Immunodeficiency

NASA Technical Reports Server (NTRS)

Shearer, William T.

1999-01-01

The National Aeronautics and Space Administration (NASA) has had sufficient concern for the well-being of astronauts traveling in space to create the National Space Biomedical Research Institute (NSBRI), which is investigating several areas of biomedical research including those of immunology. As part of the Immunology, Infection, and Hematology Team, the co-investigators of the Space Flight Immunodeficiency Project began their research projects on April 1, 1998 and are now just into the second year of work. Two areas of research have been targeted: 1) specific immune (especially antibody) responses and 2) non-specific inflammation and adhesion. More precise knowledge of these two areas of research will help elucidate the potential harmful effects of space travel on the immune system, possibly sufficient to create a secondary state of immunodeficiency in astronauts. The results of these experiments are likely to lead to the delineation of functional alterations in antigen presentation, specific immune memory, cytokine regulation of immune responses, cell to cell interactions, and cell to endothelium interactions.

Rodent Habitat on ISS: Advances in Capability for Determining Spaceflight Effects on Mammalian Physiology

NASA Technical Reports Server (NTRS)

Globus, R. K.; Choi, S.; Gong, C.; Leveson-Gower, D.; Ronca, A.; Taylor, E.; Beegle, J.

2016-01-01

Rodent research is a valuable essential tool for advancing biomedical discoveries in life sciences on Earth and in space. The National Research Counsel's Decadal survey (1) emphasized the importance of expanding NASAs life sciences research to perform long duration, rodent experiments on the International Space Station (ISS). To accomplish this objective, new flight hardware, operations, and science capabilities were developed at NASA ARC to support commercial and government-sponsored research. The flight phases of two separate spaceflight missions (Rodent Research-1 and Rodent Research-2) have been completed and new capabilities are in development. The first flight experiments carrying 20 mice were launched on Sept 21, 2014 in an unmanned Dragon Capsule, SpaceX4; Rodent Research-1 was dedicated to achieving both NASA validation and CASIS science objectives, while Rodent Reesearch-2 extended the period on orbit to 60 days. Groundbased control groups (housed in flight hardware or standard cages) were maintained in environmental chambers at Kennedy Space Center. Crewmembers previously trained in animal handling transferred mice from the Transporter into Habitats under simultaneous veterinary supervision by video streaming and were deemed healthy. Health and behavior of all mice on the ISS was monitored by video feed on a daily basis, and post-flight quantitative analyses of behavior were performed. The 10 mice from RR-1 Validation (16wk old, female C57Bl6/J) ambulated freely and actively throughout the Habitat, relying heavily on their forelimbs for locomotion. The first on-orbit dissections of mice were performed successfully, and high quality RNA (RIN values>9) and liver enzyme activities were obtained, validating the quality of sample recovery. Post-flight sample analysis revealed that body weights of FLT animals did not differ from ground controls (GC) housed in the same hardware, or vivarium controls (VIV) housed in standard cages. Organ weights analyzed post-flight showed that there were no differences between FLT and GC groups in adrenal gland and spleen weights, whereas FLT thymus and liver weights exceeded those of GC. Minimal differences between the control groups (GC and VIV) were observed. In addition, Over 3,000 aliquots collected post-flight from the four groups of mice were deposited into the Ames Life Science Data Archives for the Biospecimen Sharing Program and Genelab project. New capabilities recently developed include DEXA scanning, grip strength tests and male mice. In conclusion, new capability for long duration rodent habitation of group-housed rodents was developed and includes in-flight sample collection, thus avoiding the complication of reentry. Results obtained to date reveal the possibility of striking differences between the effects of short duration vs. long duration spaceflight. This Rodent Research system enables achievement of both basic science and translational research objectives to advance human exploration of space.

ToF-SIMS Characterization of Biocompatible Silk/Polypyrrole Electromechanical Actuators

NASA Astrophysics Data System (ADS)

Bradshaw, Nathan; Severt, Sean; Wang, Zhaoying; Klemke, Carly; Larson, Jesse; Zhu, Zihua; Murphy, Amanda; Leger, Janelle

2015-03-01

Materials capable of controlled movements that can also interface with biological environments are highly sought after for biomedical devices such as valves, blood vessel sutures, cochlear implants and controlled drug release devices. Recently we have reported the synthesis of films composed of a conductive interpenetrating network of the biopolymer silk fibroin and poly(pyrrole). These silk-PPy composites function as bilayer electromechanical actuators in a biologically-relevant environment, can be actuated repeatedly, and are able to generate forces comparable with natural muscle (>0.1 MPa), making them an ideal candidate for interfacing with biological tissues. Here, time of flight secondary ion mass spectrometry was used to investigate the migration of ions in the devices during actuation. These findings will be discussed in the context of the actuation mechanism and opportunities for further improvements in device stability and performance.

STS-44 crewmembers conduct DSO 472, Intraocular Pressure, on OV-104's middeck

NASA Image and Video Library

1991-12-01

STS044-04-001 (24 Nov-1 Dec 1991) --- Astronauts F. Story Musgrave (right) and Mario Runco, Jr., mission specialists, team up for one of the biomedical Detailed Supplementary Objective (DSO) test on the eight-day flight, this one involving intraocular pressure.

USSR and Eastern europe Scientific Abstracts, Biomedical and Behavioral Sciences. Number 55.

DTIC Science & Technology

1976-11-02

could solve the problems of the first manned flight. Can people breathe in weightlessness? Are they capable of digesting food? Is it possible in...Animals and Department of Poultry Farming (Timiryazev Agri- cultural Academy) MEAT PRODUCTIVITY OF BROILERS FED WITH DIFFERENT FATS Moscow

View of FE Stott using the BMMD in the SM

NASA Image and Video Library

2009-10-12

ISS021-E-014503 (12 Oct. 2009) --- NASA astronaut Nicole Stott, Expedition 21 flight engineer, uses the IM mass measurement device to perform the PZEh-MO-8/Body Mass Measurement Russian biomedical routine assessments in the Zvezda Service Module of the International Space Station.

PZEh-MO-8/Body Mass Measurement

NASA Image and Video Library

2009-06-30

ISS020-E-015853 (30 June 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 20 flight engineer, uses the IM mass measurement device to perform the PZEh-MO-8/Body Mass Measurement Russian biomedical routine assessments in the Zvezda Service Module of the International Space Station.

STS-58 crewmembers participate in baseline data collection

NASA Image and Video Library

1993-09-29

S93-45367 (29 Sept 1993) --- Astronaut Rhea Seddon, STS-58 payload commander, participates in biomedical data collection. The seven member crew spent an entire day recording important pre-flight data in preparation for the two week Spacelab Life Sciences (SLS-2) mission, scheduled for next month.

Mercury Project

NASA Image and Video Library

1960-01-21

The launch of the Little Joe booster for the LJ1B mission on the launch pad from the wallops Flight Facility, Wallops Island, Virginia, on January 21, 1960. This mission achieved the suborbital Mercury capsule test, testing of the escape system, and biomedical tests by using a monkey, named Miss Sam.

Life sciences report 1987

NASA Technical Reports Server (NTRS)

1987-01-01

Highlighted here are the major research efforts of the NASA Life Sciences Division during the past year. Topics covered include remote health care delivery in space, space biomedical research, gravitational biology, biospherics (studying planet Earth), the NASA Closed Ecological Life Support System (CELSS), exobiology, flight programs, international cooperation, and education programs.

Apollo Program Summary Report: Synopsis of the Apollo Program Activities and Technology for Lunar Exploration

NASA Technical Reports Server (NTRS)

1975-01-01

Overall program activities and the technology developed to accomplish lunar exploration are discussed. A summary of the flights conducted over an 11-year period is presented along with specific aspects of the overall program, including lunar science, vehicle development and performance, lunar module development program, spacecraft development testing, flight crew summary, mission operations, biomedical data, spacecraft manufacturing and testing, launch site facilities, equipment, and prelaunch operations, and the lunar receiving laboratory. Appendixes provide data on each of the Apollo missions, mission type designations, spacecraft weights, records achieved by Apollo crewmen, vehicle histories, and a listing of anomalous hardware conditions noted during each flight beginning with Apollo 4.

Biotelemetry and computer analysis of sleep processes on earth and in space.

NASA Technical Reports Server (NTRS)

Adey, W. R.

1972-01-01

Developments in biomedical engineering now permit study of states of sleep, wakefulness, and focused attention in man exposed to rigorous environments, including aerospace flight. These new sensing devices, data acquisition systems, and computational methods have also been extensively applied to clinical problems of disordered sleep. A 'library' of EEG data has been prepared for sleep in normal man, and characterized for its group features by computational analysis. Sleep in an astronaut in space flight has been examined for the first and second 'nights' of space flight. Normal 90-min cycles were detected during the second night. Sleep patterns in quadriplegic patients deprived of all sensory inputs below the neck have indicated major deviations.

PZEh-MO-8/Body Mass Measurement in Service Module

NASA Image and Video Library

2009-05-06

ISS019-E-014222 (6 May 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 19/20 flight engineer, uses the IM mass measurement device to perform the PZEh-MO-8/Body Mass Measurement Russian biomedical routine assessments in the Zvezda Service Module of the International Space Station.

PZEh-MO-8/Body Mass Measurement in Service Module

NASA Image and Video Library

2009-05-06

ISS019-E-014216 (6 May 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 19/20 flight engineer, uses the IM mass measurement device to perform the PZEh-MO-8/Body Mass Measurement Russian biomedical routine assessments in the Zvezda Service Module of the International Space Station.

Foundations of Space Biology and Medicine. Volume 3: Space Medicine and Biotechnology

NASA Technical Reports Server (NTRS)

Calvin, M. (Editor); Gazenko, O. G. (Editor)

1975-01-01

The results of medical and biological research in space are presented. Specific topics discussed include: methods of providing life support systems for astronauts, characteristics of integrated life support systems, protection against adverse factors of space flight, selection and training of astronauts, and future space biomedical research.

Space Product Development (SPD)

NASA Image and Video Library

2003-01-12

Experiments to seek solutions for a range of biomedical issues are at the heart of several investigations that will be hosted by the Commercial Instrumentation Technology Associates (ITA), Inc. Biomedical Experiments (CIBX-2) payload. CIBX-2 is unique, encompassing more than 20 separate experiments including cancer research, commercial experiments, and student hands-on experiments from 10 schools as part of ITA's ongoing University Among the Stars program. Student Marnix Aklian and ITA's Mark Bem prepare biological samples for flight as part of ITA's hands-on student outreach program on STS-95. Similar activities are a part of the CIBX-2 payload. The experiments are sponsored by NASA's Space Product Development Program (SPD).

KSC-04PD-2497

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Joe Mounts, with Boeing, monitors the Payload Test and Checkout System for the Human Research Facility (HRF) Rack -2 payload. The HRF-2 is scheduled to fly on Return to Flight Space Shuttle mission STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF Rack 1 contains an ultrasound unit and gas analyzer system and has been operational in the U.S. Lab since May 2001. HRF-2 will also be installed in the U. S. Lab and will provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U. S. Lab.

The application of integrated knowledge-based systems for the Biomedical Risk Assessment Intelligent Network (BRAIN)

NASA Technical Reports Server (NTRS)

Loftin, Karin C.; Ly, Bebe; Webster, Laurie; Verlander, James; Taylor, Gerald R.; Riley, Gary; Culbert, Chris

1992-01-01

One of NASA's goals for long duration space flight is to maintain acceptable levels of crew health, safety, and performance. One way of meeting this goal is through BRAIN, an integrated network of both human and computer elements. BRAIN will function as an advisor to mission managers by assessing the risk of inflight biomedical problems and recommending appropriate countermeasures. Described here is a joint effort among various NASA elements to develop BRAIN and the Infectious Disease Risk Assessment (IDRA) prototype. The implementation of this effort addresses the technological aspects of knowledge acquisition, integration of IDRA components, the use of expert systems to automate the biomedical prediction process, development of a user friendly interface, and integration of IDRA and ExerCISys systems. Because C language, CLIPS and the X-Window System are portable and easily integrated, they were chosen ss the tools for the initial IDRA prototype.

Biomedical results of the Skylab Program.

PubMed

Michel, E L; Johnston, R S; Dietlein, L F

1976-01-01

Skylab, the fourth in a logical sequence of USA manned space flight projects following Mercury, Gemini and Apollo, presented life scientists with their first opportunity for an in-depth study of man's response to the space environment. Extensive medical investigations were undertaken to increase our understanding of man's adaptation to the space environment and his readaptation to gravity upon return to earth. The flight durations of the three Skylab missions were progressively increased from 28 days to 59 days and, finally, 84 days. The results of these investigations of the various body systems clearly demonstrated that man can adapt to zero gravity and perform useful work during long-duration space flight. However, definite changes (some unexpected) in the vestibular, cardiovascular, musculo-skeletal, renal and electrolyte areas were documented. The most significant were: the occurrence of space motion sickness early in the missions; diminished orthostatic tolerance, both in-flight and post-flight; moderate losses of calcium, phosphorus and nitrogen; and decreased tolerance for exercise post-flight. The mechanisms responsible for these physiological responses must be understood and, if necessary, effective countermeasures developed before man can endure unlimited exposure to space flight.

Man in space - A time for perspective. [crew performance on Space Shuttle-Spacelab program

NASA Technical Reports Server (NTRS)

Winter, D. L.

1975-01-01

Factors affecting crew performances in long-term space flights are examined with emphasis on the Space Shuttle-Spacelab program. Biomedical investigations carried out during four Skylab missions indicate that initially rapid changes in certain physiological parameters, notably in cardiovascular response and red-blood-cell levels, lead to an adapted condition. Calcium loss remains a potential problem. Space Shuttle environmental control and life-support systems are described together with technology facilitating performance of mission objectives in a weightless environment. It is concluded that crew requirements are within the physical and psychological capability of astronauts, but the extent to which nonastronaut personnel will be able to participate without extensive training and pre-conditioning remains to be determined.

Biomedical study on combined effects of simulated weightlessness and emergent depressurization of spacecraft

NASA Astrophysics Data System (ADS)

Yang, T. D.; Zhang, R. G.; Wang, C. M.; Fu, H. W.; Zhang, B. L.; Zhang, J. X.

1999-01-01

Cabin emergent depressurization (CED) may occur in spacecraft during manned space flight. The purpose of this paper was to study the combined effects of simulated weightlessness (SW) and CED factors on humans and animals. It was found that the amplitude of T wave of human electrocardiograms (ECG) significantly decreased in bed rest and hypoxia compared with the control condition (P<0.05), and that suspension with pure O2 induced severer edema in the lungs of rats than that in only a pure O2 environment. SW and pure O2 caused middle ear congestion and decreased the barofunction during pressure changes. These results indicate that human response to CED factors become more serious under SW because of the blood redistribution.

BDPU, Favier places new test chamber into experiment module in LMS-1 Spacelab

NASA Image and Video Library

1996-07-09

STS078-301-021 (20 June - 7 July 1996) --- Payload specialist Jean-Jacques Favier, representing the French Space Agency (CNES), holds up a test container to a Spacelab camera. The test involves the Bubble Drop Particle Unit (BDPU), which Favier is showing to ground controllers at the Marshall Space Flight Center (MSFC) in order to check the condition of the unit prior to heating in the BDPU facility. The test container holds experimental fluid and allows experiment observation through optical windows. BDPU contains three internal cameras that are used to continuously downlink BDPU activity so that behavior of the bubbles can be monitored. Astronaut Richard M. Linnehan, mission specialist, conducts biomedical testing in the background.

An integrative approach to space-flight physiology using systems analysis and mathematical simulation

NASA Technical Reports Server (NTRS)

Leonard, J. I.; White, R. J.; Rummel, J. A.

1980-01-01

An approach was developed to aid in the integration of many of the biomedical findings of space flight, using systems analysis. The mathematical tools used in accomplishing this task include an automated data base, a biostatistical and data analysis system, and a wide variety of mathematical simulation models of physiological systems. A keystone of this effort was the evaluation of physiological hypotheses using the simulation models and the prediction of the consequences of these hypotheses on many physiological quantities, some of which were not amenable to direct measurement. This approach led to improvements in the model, refinements of the hypotheses, a tentative integrated hypothesis for adaptation to weightlessness, and specific recommendations for new flight experiments.

Man in space - The use of animal models

NASA Technical Reports Server (NTRS)

Ballard, Rodney W.; Souza, Kenneth A.

1991-01-01

The use of animal surrogates as experimental subjects in order to provide essential missing information on the effects of long-term spaceflights, to validate countermeasures, and to test medical treatment techniques is discussed. Research needs also include the definition of biomedical adaptations to flight, and the developments of standards for safe space missions to assure human health and productivity during and following flight. NASA research plans in this area are outlined. Over the next 40 years, NASA plans to concentrate on the use of rodents and nonhuman primates as the models of choice for various physiological responses observed in humans during extended stays in space. This research will include flights on the Space Shuttle, unmanned biosatellites, and the Space Station Freedom.

Metabolic and cardiovascular adaptation, monkey. NASA SMD 3, project 76, experiment 44 conducted at NASA/JSC, 14-25 May 1977

NASA Technical Reports Server (NTRS)

Pace, N.; Rahlmann, D. F.; Mains, R. C.; Kodama, A. M.; Mccutcheon, E. P.

1977-01-01

The biomedical results from an experiment on a monkey subjected to space flight conditions are reported. A background history of the development and testing of an experiment system designed to permit measurement of physiological parameters in subhuman primates during continuous, comfortable, couch restraint for periods of up to 30 days is reviewed. Of major importance in the experimental design of the system was the use of a fiberglass pod, which could be sealed and subdivided into upper and lower parts, to monitor and control the physiological responses for various parts of the animal's body. The experiment was conducted within the Spacelab Simulator for a period of 11 days. Data recorded includes: Spacelab Simulator cabin temperature; ventilation rate; pod internal temperature; fraction percent oxygen; fraction percent carbon dioxide; oxygen consumption rate; carbon dioxide production rate; respiratory quotient; intrathoracic temperature; heart rate; mean aortic pressure; mean ventricular pressure; diurnal variation of parameters measured; comparison of mean preflight, flight, and postflight values of the parameters measured; and correlation matrix for the parameters measured.

The MARS2013 Mars analog mission.

PubMed

Groemer, Gernot; Soucek, Alexander; Frischauf, Norbert; Stumptner, Willibald; Ragonig, Christoph; Sams, Sebastian; Bartenstein, Thomas; Häuplik-Meusburger, Sandra; Petrova, Polina; Evetts, Simon; Sivenesan, Chan; Bothe, Claudia; Boyd, Andrea; Dinkelaker, Aline; Dissertori, Markus; Fasching, David; Fischer, Monika; Föger, Daniel; Foresta, Luca; Fritsch, Lukas; Fuchs, Harald; Gautsch, Christoph; Gerard, Stephan; Goetzloff, Linda; Gołebiowska, Izabella; Gorur, Paavan; Groemer, Gerhard; Groll, Petra; Haider, Christian; Haider, Olivia; Hauth, Eva; Hauth, Stefan; Hettrich, Sebastian; Jais, Wolfgang; Jones, Natalie; Taj-Eddine, Kamal; Karl, Alexander; Kauerhoff, Tilo; Khan, Muhammad Shadab; Kjeldsen, Andreas; Klauck, Jan; Losiak, Anna; Luger, Markus; Luger, Thomas; Luger, Ulrich; McArthur, Jane; Moser, Linda; Neuner, Julia; Orgel, Csilla; Ori, Gian Gabriele; Paternesi, Roberta; Peschier, Jarno; Pfeil, Isabella; Prock, Silvia; Radinger, Josef; Ramirez, Barbara; Ramo, Wissam; Rampey, Mike; Sams, Arnold; Sams, Elisabeth; Sandu, Oana; Sans, Alejandra; Sansone, Petra; Scheer, Daniela; Schildhammer, Daniel; Scornet, Quentin; Sejkora, Nina; Stadler, Andrea; Stummer, Florian; Taraba, Michael; Tlustos, Reinhard; Toferer, Ernst; Turetschek, Thomas; Winter, Egon; Zanella-Kux, Katja

2014-05-01

We report on the MARS2013 mission, a 4-week Mars analog field test in the northern Sahara. Nineteen experiments were conducted by a field crew in Morocco under simulated martian surface exploration conditions, supervised by a Mission Support Center in Innsbruck, Austria. A Remote Science Support team analyzed field data in near real time, providing planning input for the management of a complex system of field assets; two advanced space suit simulators, four robotic vehicles, an emergency shelter, and a stationary sensor platform in a realistic work flow were coordinated by a Flight Control Team. A dedicated flight planning group, external control centers for rover tele-operations, and a biomedical monitoring team supported the field operations. A 10 min satellite communication delay and other limitations pertinent to human planetary surface activities were introduced. The fields of research for the experiments were geology, human factors, astrobiology, robotics, tele-science, exploration, and operations research. This paper provides an overview of the geological context and environmental conditions of the test site and the mission architecture, in particular the communication infrastructure emulating the signal travel time between Earth and Mars. We report on the operational work flows and the experiments conducted, including a deployable shelter prototype for multiple-day extravehicular activities and contingency situations.

Effects of body posture on the interpretation of biomedical data obtained from manned missions

NASA Technical Reports Server (NTRS)

Nicogossian, Arnauld; Leach-Huntoon, Carolyn; Charles, John; Pool, Sam; Leonard, Joel I.

1989-01-01

The role that different body postures may have on the interpretation of inflight results is studied. The cardiovascular measurements taken in the upright position more closely approximated the findings from space flight in the short-duration missions. However, the supine position most approximated the long-duration missions.

What's New in...Science Teacher Preparation.

ERIC Educational Resources Information Center

Borowiec, Jonathan B., James, Robert K.

2000-01-01

Argues that NASA's 20-year research effort which will culminate with a manned flight to Mars is an opportunity to involve students in the science of that effort. Describes the National Space Biomedical Research Institute (NSBRI) Teacher Academy Program, a program designed to reach science teachers so that they can prepare their students to…

Animals in biomedical space research

NASA Technical Reports Server (NTRS)

Phillips, R. W.

1986-01-01

Rat and squirrel monkeys experiments have been planned in concert with human experiments to help answer fundamental questions concerning the effect of weightlessness on mammalism function. For the most part, these experiments focus on identified changes noted in humans during space flight. Utilizing space laboratory facilities, manipulative experiments can be completed while animals are still in orbit. Other experiments are designed to study changes in gravity receptor structure and function and the effect of weightlessness on early vertibrate development. Following these preliminary animal experiments on Spacelab Shuttle flights, longer term programs of animal investigation will be conducted on Space Station.

KSC-04PD-2495

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Nancy Lowry (left) and Mikiko Ujihara, with Boeing, monitor the Payload Test and Checkout System for the Human Research Facility (HRF) Rack -2 payload. The HRF-2 is scheduled to fly on Return to Flight Space Shuttle mission STS- 114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF Rack 1 contains an ultrasound unit and gas analyzer system and has been operational in the U.S. Lab since May 2001. HRF-2 will also be installed in the U. S. Lab and will provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U. S. Lab.

Spacelab Life Sciences 3 biomedical research using the Rhesus Research Facility

NASA Technical Reports Server (NTRS)

Ballard, R. W.; Searby, N. D.; Stone, L. S.; Hogan, R. P.; Viso, M.; Venet, M.

1992-01-01

In 1985, a letter of agreement was signed between the French space agency, CNES, and NASA, formally initiating a joint venture called the RHESUS Project. The goal of this project is to provide a facility to fly rhesus monkeys (Macaca mulatta) to support spaceflight experiments which are applicable but not practical to carry out on human subjects. Biomedical investigations in behavior/performance, immunology/microbiology, muscle physiology, cardiopulmonary physiology, bone/calcium physiology, regulatory physiology, and neurophysiology disciplines will be performed. The Rhesus Research Facility, hardware capable of supporting two adult rhesus monkeys in a microgravity environment, is being developed for a first flight on Spacelab Life Sciences in early 1996.

User and Task Analysis of the Flight Surgeon Console at the Mission Control Center of the NASA Johnson Space Center

NASA Technical Reports Server (NTRS)

Johnson, Kathy A.; Shek, Molly

2003-01-01

Astronauts in a space station are to some extent like patients in an intensive care unit (ICU). Medical support of a mission crew will require acquisition, transmission, distribution, integration, and archiving of significant amounts of data. These data are acquired by disparate systems and will require timely, reliable, and secure distribution to different communities for the execution of various tasks of space missions. The goal of the Comprehensive Medical Information System (CMIS) Project at Johnson Space Center Flight Medical Clinic is to integrate data from all Medical Operations sources, including the reference information sources and the electronic medical records of astronauts. A first step toward the full CMIS implementation is to integrate and organize the reference information sources and the electronic medical record with the Flight Surgeons console. In order to investigate this integration, we need to understand the usability problems of the Flight Surgeon's console in particular and medical information systems in general. One way to achieve this understanding is through the use of user and task analyses whose general purpose is to ensure that only the necessary and sufficient task features that match users capacities will be included in system implementations. The goal of this summer project was to conduct user and task analyses employing cognitive engineering techniques to analyze the task of the Flight Surgeons and Biomedical Engineers (BMEs) while they worked on Console. The techniques employed were user interviews, observations and a questionnaire to collect data for which a hierarchical task analysis and an information resource assessment were performed. They are described in more detail below. Finally, based on our analyses, we make recommendations for improvements to the support structure.

STS-58 crewmembers participate in baseline data collection

NASA Image and Video Library

1993-09-29

S93-45373 (29 Sept 1993) --- Astronaut Rhea Seddon, STS-58 payload commander, is in a piloting simulator as part of a pre-flight data collection project for neurovestibular functions. The seven Spacelab Life Sciences (SLS-2) crew members devoted a full day to miscellaneous biomedical data collection in preparation for next month's two week mission aboard Columbia.

Causes and consequences of reduced blood volume in space flight - A multi-discipline modeling study

NASA Technical Reports Server (NTRS)

Leonard, J. I.

1983-01-01

A group of mathematical models of various physiological systems have been developed and applied to studying problems associated with adaptation to weightlessness. One biomedical issue which could be addressed by at least three of these models from varying perspectives was the reduction in blood volume that universally occurs in astronauts. Accordingly, models of fluid-electrolyte, erythropoiesis, and cardiovascular regulation were employed to study the causes and consequences of blood volume loss during space flight. This analysis confirms the notion that alterations of blood volume are central to an understanding of adaptation to prolonged space flight. More importantly, the modeling studies resulted in specific hypotheses accounting for plasma volume and red cell mass losses and testable predictions concerning the behavior of the circulatory system.

Medical Operations Console Procedure Evaluation: BME Response to Crew Call Down for an Emergency

NASA Technical Reports Server (NTRS)

Johnson-Troop; Pettys, Marianne; Hurst, Victor, IV; Smaka, Todd; Paul, Bonnie; Rosenquist, Kevin; Gast, Karin; Gillis, David; McCulley, Phyllis

2006-01-01

International Space Station (ISS) Mission Operations are managed by multiple flight control disciplines located at the lead Mission Control Center (MCC) at NASA-Johnson Space Center (JSC). ISS Medical Operations are supported by the complementary roles of Flight Surgeons (Surgeon) and Biomedical Engineer (BME) flight controllers. The Surgeon, a board certified physician, oversees all medical concerns of the crew and the BME provides operational and engineering support for Medical Operations Crew Health Care System. ISS Medical Operations is currently addressing the coordinated response to a crew call down for an emergent medical event, in particular when the BME is the only Medical Operations representative in MCC. In this case, the console procedure BME Response to Crew Call Down for an Emergency will be used. The procedure instructs the BME to contact a Surgeon as soon as possible, coordinate with other flight disciplines to establish a Private Medical Conference (PMC) for the crew and Surgeon, gather information from the crew if time permits, and provide Surgeon with pertinent console resources. It is paramount that this procedure is clearly written and easily navigated to assist the BME to respond consistently and efficiently. A total of five BME flight controllers participated in the study. Each BME participant sat in a simulated MCC environment at a console configured with resources specific to the BME MCC console and was presented with two scripted emergency call downs from an ISS crew member. Each participant used the procedure while interacting with analog MCC disciplines to respond to the crew call down. Audio and video recordings of the simulations were analyzed and each BME participant's actions were compared to the procedure. Structured debriefs were conducted at the conclusion of both simulations. The procedure was evaluated for its ability to elicit consistent responses from each BME participant. Trials were examined for deviations in procedure task completion and/or navigation, in particular the execution of the Surgeon call sequence. Debrief comments were used to analyze unclear procedural steps and to discern any discrepancies between the procedure and generally accepted BME actions. The sequence followed by BME participants differed considerably from the sequence intended by the procedure. Common deviations included the call sequence used to contact Surgeon, the content of BME and crew interaction and the gathering of pertinent console resources. Differing perceptions of task priority and imprecise language seem to have caused multiple deviations from the procedure s intended sequence. The study generated 40 recommendations for the procedure, of which 34 are being implemented. These recommendations address improving the clarity of the instructions, identifying training considerations, expediting Surgeon contact, improving cues for anticipated flight control team communication and identifying missing console tools.

Anabolic and Catabolic Signaling Pathways in mouse Longissimus Dorsi after 30-day BION-M1 Spaceflight and Subsequent Recovery

NASA Astrophysics Data System (ADS)

Mirzoev, Timur; Blottner, Dieter; Shenkman, Boris; Lomonosova, Yulia; Vilchinskaya, Natalia; Nemirovskaya, Tatiana; Salanova, Michele

The aim of the study was to analyze some of the key markers regulating anabolic and catabolic processes in mouse m. longissimus dorsi, an important back muscle system for trunk stabilization, following 30-day spaceflight and 8-day recovery period. C57/black mice were divided into 3 groups: 1) Vivarium Control (n=7), 2) Flight (n=5), 3) Recovery (n=5). The experiment was carried out in accordance with the rules of biomedical ethics certified by the Russian Academy of Sciences Committee on Bioethics. Using Western-blotting analysis we determined the content of IRS-1, p-AMPK, MURF-1 and eEF2 in m. longissimus dorsi. The content of IRS-1 in mice m. longissimus dorsi after the 30-day flight did not differ from the control group, however, in the Recovery group IRS-1 level was 80% higher (p<0.05) as compared to Control. Phospho-AMPK content remained unchanged. In the Recovery group there was an increase of eEF2 by 75% compared to the Control (p<0.05). After spaceflight MuRF-1 content was increased more than 2 times compared to the control animals. Thus, our findings showed that the work of the IRS-1 - dependent signaling pathway is only active in the recovery period. The content of the ubiquitin-ligase MURF-1 that takes parts in degrading myosin heavy chain was increased after the spaceflight, however, after 8-day recovery period MURF-1 level did not exceed the control indicating normalization of protein degradation in m. longissimus dorsi. The work was supported by the program of basic research of RAS and Federal Space Program of Russia for the period of 2006-2015.

Use of controlled vocabularies to improve biomedical information retrieval tasks.

PubMed

Pasche, Emilie; Gobeill, Julien; Vishnyakova, Dina; Ruch, Patrick; Lovis, Christian

2013-01-01

The high heterogeneity of biomedical vocabulary is a major obstacle for information retrieval in large biomedical collections. Therefore, using biomedical controlled vocabularies is crucial for managing these contents. We investigate the impact of query expansion based on controlled vocabularies to improve the effectiveness of two search engines. Our strategy relies on the enrichment of users' queries with additional terms, directly derived from such vocabularies applied to infectious diseases and chemical patents. We observed that query expansion based on pathogen names resulted in improvements of the top-precision of our first search engine, while the normalization of diseases degraded the top-precision. The expansion of chemical entities, which was performed on the second search engine, positively affected the mean average precision. We have shown that query expansion of some types of biomedical entities has a great potential to improve search effectiveness; therefore a fine-tuning of query expansion strategies could help improving the performances of search engines.

The Proceedings of the Skylab Life Sciences Symposium, volume 2

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.

1974-01-01

The three manned Skylab missions resulted in biomedical experiment data in the areas of neurophysiology, musculoskeletal physiology, biochemistry, hematology, cytology, cardiovascular and respiratory metabolic functions: as well as detailed test objectives involving crew health and environment procedures. Major emphasis was placed on results from the last mission, Skylab 4, which covered 84 days of in-flight data collection. Many new norms were defined for normal man living and operating in a unique environment. While man is quite adaptable to this unique environment, many of the changes observed in Skylab require additional research for future flights lasting very long periods of time such as a Mars mission requiring 18 months.

The Proceedings of the Skylab Life Sciences Symposium, Volume 1

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.

1974-01-01

The three manned Skylab missions resulted in biomedical experiment data in the areas of neurophysiology, musculoskeletal physiology, biochemistry, hematology, cytology, cardiovascular and respiratory metabolic functions: as well as detailed test objectives involving crew health and environment procedures. Major emphasis was placed on results from the last mission, Skylab 4, which covered 84 days of in-flight data collection. Many new norms were defined for normal man living and operating in a unique environment. While man is quite adaptable to this unique environment, many of the changes observed in Skylab require additional research for future flights lasting very long periods of time such as a Mars mission requiring 18 months.

Benefits attained from space flight in pre-clinical evaluation of candidate drugs

NASA Astrophysics Data System (ADS)

Stodieck, Louis S.; Bateman, Ted; Ayers, Reed; Ferguson, Virginia; Simske, Steve

1998-01-01

Modern medicine has made great strides in recent decades. The promises of biotechnology and advances in gene identification and manipulation offer tremendous potential for treatment of disease. However, developing new drug therapies by biotechnology and pharmaceutical companies is still a very costly and time consuming process. One of the important milestones in drug development is the successful completion of preclinical evaluation. During this phase, drug candidates must be shown to be safe, yet effective as a treatment of the target disease or disorder. Critical for preclinical testing is the availability of biomedical test models that adequately mimic the target disease. A good model will 1) allow confident prediction of a drug's effects before expensive clinical trials are begun, 2) provide convincing data for use in an FDA new drug application and 3) minimize the time required for testing. Space flight may offer a completely unique and new set of biomedical models for use in pharmaceutical testing. This paper highlights some examples of recent experiments done in space to test new compounds for Chiron, (Emmeryville, CA) and discusses the importance of the International Space Station to greatly expand such commercial opportunities.

Utilization of biosensors and chemical sensors for space applications

NASA Technical Reports Server (NTRS)

Bonting, S. L.

1992-01-01

There will be a need for a wide array of chemical sensors for biomedical experimentation and for the monitoring of water and air recycling processes on Space Station Freedom. The infrequent logistics flights of the Space Shuttle will necessitate onboard analysis. The advantages of biosensors and chemical sensors over conventional analysis onboard spacecraft are manifold. They require less crew time, space, and power. Sample treatment is not needed. Real time or near-real time monitoring is possible, in some cases on a continuous basis. Sensor signals in digitized form can be transmitted to the ground. Types and requirements for chemical sensors to be used in biomedical experimentation and monitoring of water recycling during long-term space missions are discussed.

Milestones of space medicine development in Russia (establishment and evolution of the Institute of Biomedical Problems).

PubMed

Gazenko, O G

1997-10-01

This paper describes the history of the Institute of Biomedical Problems (IMBP): its birth and development. IMBP's directors were: Andrei V. Libedinsky (1963-1965), Vasily V. Parin (1965-1967), Oleg G. Gazenko (1968-1988), and Anatoly I. Grigoriev (1988 to the present). Most of the early employees of IMBP came from the USSR Air Force Institute of Aviation Medicine and the USSR Ministry of Health Institute of Biophysics. The major goals of IMBP were: development of a system of medical monitoring and support of long-duration space missions, selection and training of civilian crew members, bioengineering testing of flight equipment, and development of life support system concepts and requirements. The paper presents major results of the above research activities.

KSC-04pd1505

NASA Image and Video Library

2004-07-08

KENNEDY SPACE CENTER, FLA. - In the water for a practice dive in the ocean offshore from Key Largo are the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission team: (left to right) Tara Ruttley, a biomedical engineer, and astronauts Nick Patrick, John Herrington and Doug Wheelock. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1506

NASA Image and Video Library

2004-07-08

KENNEDY SPACE CENTER, FLA. - A dive boat is moored to the Life Support Buoy, anchored above the NOAA undersea station Aquarius, offshore from Key Largo. Underwater is the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission team: (left to right) Tara Ruttley, a biomedical engineer, and astronauts Nick Patrick, John Herrington and Doug Wheelock. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy.

KSC-04pd1501

NASA Image and Video Library

2004-07-08

KENNEDY SPACE CENTER, FLA. - Onboard the dive boat, members of the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission don dive suits. From left are Tara Ruttley, a biomedical engineer, and astronauts Nick Patrick and Doug Wheelock. John Herrington is mission commander. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius offshore from Key Largo - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1510

NASA Image and Video Library

2004-07-11

KENNEDY SPACE CENTER, FLA. - In the water for a practice dive in the ocean offshore from Key Largo is astronaut John Herrington. He is commander of the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission team. The others are Nick Patrick, Doug Wheelock, and Tara Ruttley, a biomedical engineer. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1504

NASA Image and Video Library

2004-07-08

KENNEDY SPACE CENTER, FLA. - In the water for a practice dive in the ocean offshore from Key Largo is astronaut John Herrington. He is commander of the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission team. The others are Nick Patrick, Doug Wheelock, and Tara Ruttley, a biomedical engineer. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04PD-2492

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, Gaschen Geissen and Elton Witt, with Lockheed Martin, monitor the Payload Test and Checkout System for the Human Research Facility (HRF) Rack -2 payload. The HRF-2 is scheduled to fly on Return to Flight Space Shuttle mission STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF Rack 1 contains an ultrasound unit and gas analyzer system and has been operational in the U.S. Lab since May 2001. HRF-2 will also be installed in the U. S. Lab and will provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U. S. Lab.

Advanced Refrigerator/Freezer Technology Development. Technology Assessment

NASA Technical Reports Server (NTRS)

Gaseor, Thomas; Hunter, Rick; Hamill, Doris

1996-01-01

The NASA Lewis Research Center, through contract with Oceaneering Space Systems, is engaged in a project to develop advanced refrigerator/freezer (R/F) technologies for future Life and Biomedical Sciences space flight missions. The first phase of this project, a technology assessment, has been completed to identify the advanced R/F technologies needed and best suited to meet the requirements for the five R/F classifications specified by Life and Biomedical Science researchers. Additional objectives of the technology assessment were to rank those technologies based on benefit and risk, and to recommend technology development activities that can be accomplished within this project. This report presents the basis, the methodology, and results of the R/F technology assessment, along with technology development recommendations.

Advanced flight hardware for organic separations

NASA Astrophysics Data System (ADS)

Deuser, Mark S.; Vellinger, John C.; Weber, John T.

1997-01-01

Aqueous Two-Phase Partitioning (ATPP) is a unique separation technique which allows purification and classification of biological materials. SHOT has employed the ATPP process in separation equipment developed for both space and ground applications. Initial equipment development and research focused on the ORganic SEParation (ORSEP) space flight experiments that were performed on suborbital rockets and the shuttle. ADvanced SEParations (ADSEP) technology was developed as the next generation of ORSEP equipment through a NASA Small Business Innovation Research (SBIR) contract. Under the SBIR contract, a marketing study was conducted, indicating a growing commercial market exists among biotechnology firms for ADSEP equipment and associated flight research and development services. SHOT is preparing to begin manufacturing and marketing laboratory versions of the ADSEP hardware for the ground-based market. In addition, through a self-financed SBIR Phase III effort, SHOT fabricated and integrated the ADSEP flight hardware for a commercially-driven flight experiment as the initial step in marketing space processing services. The ADSEP ground-based and microgravity research is expected to play a vital role in developing important new biomedical and pharmaceutical products.

Current biomedical waste management practices and cross-infection control procedures of dentists in India.

PubMed

Singh, Balendra Pratap; Khan, Suleman A; Agrawal, Neeraj; Siddharth, Ramashanker; Kumar, Lakshya

2012-06-01

To investigate the knowledge, attitudes and behaviour of dentists working in dental clinics and dental hospitals regarding biomedical waste management and cross-infection control. A national survey was conducted. Self-administered questionnaires were sent to 800 dentists across India. A total of 494 dentists responded, giving a response rate of 61.8%. Of these, 228 of 323 (70.6%) general dentists reported using boiling water as a sterilising medium and 339 (68.6%) dentists reported disposing of hazardous waste such as syringes, blades and ampoules in dustbins and emptying these into municipal corporation bins. Dentists should undergo continuing education programmes on biomedical waste management and infection control guidelines. Greater cooperation between dental clinics and hospitals and pollution control boards is needed to ensure the proper handling and disposal of biomedical waste. © 2012 FDI World Dental Federation.

Haughton-Mars Project (HMP)/NASA 2006 Lunar Medical Contingency Simulation: An Overview

NASA Technical Reports Server (NTRS)

Scheuring, R. A.; Jones, J. A.; Lee, P.; Comtois, J. M.; Chappell, S.; Rafiq, A.; Braham, S.; Hodgson, E.; Sullivan, P.; Wilkinson, N.

2006-01-01

Medical requirements are currently being developed for NASA's space exploration program. Lunar surface operations for crews returning to the moon will be performed on a daily basis to conduct scientific research and construct a lunar habitat. Inherent to aggressive surface activities is the potential risk of injury to crew members. To develop an evidence-base for handling medical contingencies on the lunar surface, a simulation project was conducted using the moon-Mars analog environment at Devon Island, Nunavut, high Canadian Arctic. A review of the Apollo lunar surface activities and personal communications with Apollo lunar crew members provided a knowledge base of plausible scenarios that could potentially injure an astronaut during a lunar extravehicular activity. Objectives were established to 1) demonstrate stabilization, field extraction and transfer an injured crew member to the habitat and 2) evaluate audio, visual and biomedical communication capabilities with ground controllers at multiple mission control centers. The simulation project s objectives were achieved. Among these objectives were 1) extracting a crew member from a sloped terrain by a two-member team in a 1-g analog environment, 2) establishing real-time communication to multiple space centers, 3) providing biomedical data to flight controllers and crew members, and 4) establishing a medical diagnosis and treatment plan from a remote site. The simulation project provided evidence for the types of equipment and methods needed for planetary space exploration. During the project, the crew members were confronted with a number of unexpected scenarios including environmental, communications, EVA suit, and navigation challenges. These trials provided insight into the challenges of carrying out a medical contingency in an austere environment. The knowledge gained from completing the objectives of this project will be incorporated into the exploration medical requirements involving an incapacited astronaut on the lunar surface.

Professional Identification for Biomedical Engineers

ERIC Educational Resources Information Center

Long, Francis M.

1973-01-01

Discusses four methods of professional identification in biomedical engineering including registration, certification, accreditation, and possible membership qualification of the societies. Indicates that the destiny of the biomedical engineer may be under the control of a new profession, neither the medical nor the engineering. (CC)

Humans in Space: Summarizing the Medico-Biological Results of the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Risin, Diana; Stepaniak, P. C.; Grounds, D. J.

2011-01-01

As we celebrate the 50th anniversary of Gagarin's flight that opened the era of Humans in Space we also commemorate the 30th anniversary of the Space Shuttle Program (SSP) which was triumphantly completed by the flight of STS-135 on July 21, 2011. These were great milestones in the history of Human Space Exploration. Many important questions regarding the ability of humans to adapt and function in space were answered for the past 50 years and many lessons have been learned. Significant contribution to answering these questions was made by the SSP. To ensure the availability of the Shuttle Program experiences to the international space community NASA has made a decision to summarize the medico-biological results of the SSP in a fundamental edition that is scheduled to be completed by the end of 2011 beginning 2012. The goal of this edition is to define the normal responses of the major physiological systems to short-duration space flights and provide a comprehensive source of information for planning, ensuring successful operational activities and for management of potential medical problems that might arise during future long-term space missions. The book includes the following sections: 1. History of Shuttle Biomedical Research and Operations; 2. Medical Operations Overview Systems, Monitoring, and Care; 3. Biomedical Research Overview; 4. System-specific Adaptations/Responses, Issues, and Countermeasures; 5. Multisystem Issues and Countermeasures. In addition, selected operational documents will be presented in the appendices. The chapters are written by well-recognized experts in appropriate fields, peer reviewed, and edited by physicians and scientists with extensive expertise in space medical operations and space-related biomedical research. As Space Exploration continues the major question whether humans are capable of adapting to long term presence and adequate functioning in space habitats remains to be answered We expect that the comprehensive review of the medico-biological results of the SSP along with the data collected during the missions on the space stations (Mir and ISS) provides a good starting point in seeking the answer to this question.

Composite annotations: requirements for mapping multiscale data and models to biomedical ontologies

PubMed Central

Cook, Daniel L.; Mejino, Jose L. V.; Neal, Maxwell L.; Gennari, John H.

2009-01-01

Current methods for annotating biomedical data resources rely on simple mappings between data elements and the contents of a variety of biomedical ontologies and controlled vocabularies. Here we point out that such simple mappings are inadequate for large-scale multiscale, multidomain integrative “virtual human” projects. For such integrative challenges, we describe a “composite annotation” schema that is simple yet sufficiently extensible for mapping the biomedical content of a variety of data sources and biosimulation models to available biomedical ontologies. PMID:19964601

KSC-04pd1502

NASA Image and Video Library

2004-07-08

KENNEDY SPACE CENTER, FLA. - Getting ready to enter the water on a practice dive in the ocean offshore from Key Largo are Tara Ruttley (below) and Nick Patrick (above). The two are members of the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission team. Ruttley is a biomedical engineer. The others are astronauts John Herrington, mission commander, and Doug Wheelock. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1503

NASA Image and Video Library

2004-07-08

KENNEDY SPACE CENTER, FLA. - Getting ready to enter the water on a practice dive in the ocean offshore from Key Largo is Nick Patrick. He is a member of the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission team. The others are astronauts John Herrington, mission commander, and Doug Wheelock, plus Tara Ruttley, a biomedical engineer. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

STS-32 crewmembers hold finish line banner as MS Low races on treadmill

NASA Image and Video Library

1990-01-20

STS032-03-021 (9-20 Jan. 1990) --- Three crew members aboard the Space Shuttle Columbia enjoy one of the lighter moments of the 11-day mission on the flight deck. Astronaut G. David Low "runs" on a treadmill device while astronauts Daniel C. Brandenstein, left, and James D. Wetherbee look on. Wetherbee's mother competed in a marathon in Houston while the crew members had their own in-space version. The treadmill served as an exerciser and also was an important element of onboard biomedical testing. This picture was used by the astronauts at their January 30, 1990 Post Flight Press Conference (PFPC) at the Johnson Space Center (JSC).

The Life Sciences program at the NASA Ames Research Center - An overview

NASA Technical Reports Server (NTRS)

Vernikos-Danellis, Joan; Sharp, Joseph C.

1989-01-01

The research projects planned for the Life Sciences program have a goal of answering basic questions concerning the nature of life itself and its evolution in the universe from basic elements, as well as the search for extraterrestrial intelligence. The program also includes studies of the evolution and development of life on the planet earth, and the global changes occurring today that affect life on the earth. The paper describes the simulation models developed to study the effects of space, the flight projects of the program, and the biomedical program, which currently focuses on the physiological changes in the human body that are associated with space flights and the interactions among these changes.

Assessing the practice of biomedical ontology evaluation: Gaps and opportunities.

PubMed

Amith, Muhammad; He, Zhe; Bian, Jiang; Lossio-Ventura, Juan Antonio; Tao, Cui

2018-04-01

With the proliferation of heterogeneous health care data in the last three decades, biomedical ontologies and controlled biomedical terminologies play a more and more important role in knowledge representation and management, data integration, natural language processing, as well as decision support for health information systems and biomedical research. Biomedical ontologies and controlled terminologies are intended to assure interoperability. Nevertheless, the quality of biomedical ontologies has hindered their applicability and subsequent adoption in real-world applications. Ontology evaluation is an integral part of ontology development and maintenance. In the biomedicine domain, ontology evaluation is often conducted by third parties as a quality assurance (or auditing) effort that focuses on identifying modeling errors and inconsistencies. In this work, we first organized four categorical schemes of ontology evaluation methods in the existing literature to create an integrated taxonomy. Further, to understand the ontology evaluation practice in the biomedicine domain, we reviewed a sample of 200 ontologies from the National Center for Biomedical Ontology (NCBO) BioPortal-the largest repository for biomedical ontologies-and observed that only 15 of these ontologies have documented evaluation in their corresponding inception papers. We then surveyed the recent quality assurance approaches for biomedical ontologies and their use. We also mapped these quality assurance approaches to the ontology evaluation criteria. It is our anticipation that ontology evaluation and quality assurance approaches will be more widely adopted in the development life cycle of biomedical ontologies. Copyright © 2018 Elsevier Inc. All rights reserved.

SLS-1 flight experiments preliminary significant results

NASA Technical Reports Server (NTRS)

1992-01-01

Spacelab Life Sciences-1 (SLS-1) is the first of a series of dedicated life sciences Spacelab missions designed to investigate the mechanisms involved in the physiological adaptation to weightlessness and the subsequent readaptation to 1 gravity (1 G). Hypotheses generated from the physiological effects observed during earlier missions led to the formulation of several integrated experiments to determine the underlying mechanisms responsible for the observed phenomena. The 18 experiments selected for flight on SLS-1 investigated the cardiovascular, cardiopulmonary, regulatory physiology, musculoskeletal, and neuroscience disciplines in both human and rodent subjects. The SLS-1 preliminary results gave insight to the mechanisms involved in the adaptation to the microgravity environment and readaptation when returning to Earth. The experimental results will be used to promote health and safety for future long duration space flights and, as in the past, will be applied to many biomedical problems encountered here on Earth.

Psychophysiology of Spaceflight and Aviation

NASA Technical Reports Server (NTRS)

Cowings, Patricia; Toscano, William

2013-01-01

In space, the absence of gravity alone causes unique physiological stress. Significant biomedical changes, across multiple organ systems, such as body fluid redistribution, diminished musculoskeletal strength, changes in cardiac function and sensorimotor control have been reported. The time course of development of these disorders and severity of symptoms experienced by individuals varies widely. Space motion sickness (SMS) is an example of maladaptation to microgravity, which occurs early in the mission and can have profound effects on physical health and crew performance. Disturbances in sleep quality, perception, emotional equilibrium and mood have also been reported, with impact to health and performance varying widely across individuals. And lastly, post-flight orthostatic intolerance, low blood pressure experienced after returning to Earth, is also of serious concern. Both the Russian and American space programs have a varied list of human errors and mistakes, which adversely impacted mission goals. Continued probability of human exposure to microgravity for extended time periods provides a rationale for the study of the effects of stress. The primary focus of this research group is directed toward examining individual differences in: (a) prediction of susceptibility to these disorders, (b) assessment of symptom severity, (c) evaluation of the effectiveness of countermeasures, and (d) developing and testing a physiological training method, Autogenic-Feedback Training Exercise (AFTE) as a countermeasure with multiple applications. The present paper reports on the results of a series of human flight experiments with AFTE aboard the Space Shuttle and Mir Space Station, and during emergency flight scenarios on Earth.

Biomedical analysis of rat body hair after hindlimb suspension for 14 days

NASA Astrophysics Data System (ADS)

Terada, Masahiro; Kawano, Fuminori; Ishioka, Noriaki; Higashibata, Akira; Majima, Hideyuki J.; Yamazaki, Takashi; Watanabe-Asaka, Tomomi; Niihori, Maki; Nakao, Reiko; Yamada, Shin; Mukai, Chiaki; Ohira, Yoshinobu

2012-04-01

The levels of 26 minerals in rat body hair were analyzed in control and hindlimb-suspended Wistar Hannover rats (n=5 each). We quantified the levels of 22 minerals in this experiment. However, we were unable to measure the levels of 4 minerals (Be, V, Cd, and Hg) quantitatively because they were below the limit of detection. Of the 22 quantified, the levels of 19 minerals were not significantly different between control and hindlimb-suspended groups. The levels of 3 minerals (Pb, Cr, and Al) tended to be higher in the hindlimb-suspended group than in the control group; however, this difference was not significant. The concentrations of 3 other minerals (I, K, and Mg) were significantly different between the 2 groups. The iodine (I) level was 58.2% higher in the hindlimb-suspended group than in the control group (P<0.05). Potassium (K) and magnesium (Mg) levels were 55.2% and 20.4% lower, respectively, in the experimental group (P<0.05 in both cases). These results indicate that a physiological change in mineral metabolism resulting from physical or mental stress, such as hindlimb suspension, is reflected in body hair. The Japan Aerospace Exploration Agency (JAXA) has initiated a human research study to investigate the effects of long-term space flight on gene expression and mineral metabolism by analyzing hair samples of astronauts who stayed in the International Space Station (ISS) for 6 months. We believe that hindlimb suspension for 14 days can simulate the effects of an extremely severe environment, such as space flight, because the hindlimb suspension model elicits a rapid physiological change in skeletal muscle, bone, and fluid shift even in the short term. These results also suggest that we can detect various effects on the body by analyzing the human scalp hair shaft.

Remotely-actuated biomedical switch

NASA Technical Reports Server (NTRS)

Lee, R. D.

1969-01-01

Remotely-actuated biomedical switching circuit using transistors consumes no power in the off position and can be actuated by a single-frequency telemetry pulse to control implanted instrumentation. Silicon controlled rectifiers permit the circuit design which imposes zero drain on supply batteries when not in use.

USSR Report, Life Sciences, Biomedical and Behavioral Sciences, No. 39

DTIC Science & Technology

1983-08-02

professional " handwriting ." Commanders of advance units [chasti] and subunits [podrazdeleniya], when analyzing high-altitude flights and pilot actions...in morbidity levels from 1966 to 1980 were much greater in children than in adults , This has been particularly true for older schoolchildren in...recent times. Children contacted viral hepatitis 3,4 to 6,5 times more frequently than adults . Half of all cases occur from September to December

The BIMDA shuttle flight mission - A low cost MPS payload

NASA Technical Reports Server (NTRS)

Holemans, Jaak; Cassanto, John M.; Morrison, Dennis; Rose, Alan; Luttges, Marvin

1990-01-01

The design, operation, and experimental protocol of the Bioserve-ITA Materials Dispersion Apparatus Payload (BIMDA) to be flown on the Space Shuttle on STS-37 are described. The aim of BIMDA is to investigate the methods and commercial potential of biomedical and fluid science applications in the microgravity environment. The BIMDA payload operations are diagrammed, and the payload components and experiments are listed, including the investigators and sponsoring institutions.

Assessing the Likelihood of Rare Medical Events in Astronauts

NASA Technical Reports Server (NTRS)

Myers, Jerry G., Jr.; Leandowski, Beth E.; Brooker, John E.; Weaver, Aaron S.

2011-01-01

Despite over half a century of manned space flight, the space flight community is only now coming to fully assess the short and long term medical dangers of exposure to reduced gravity environments. Further, as new manned spacecraft are designed and with the advent of commercial flight capabilities to the general public, a full understanding of medical risk becomes even more critical for maintaining and understanding mission safety and crew health. To address these critical issues, the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) has begun to address the medical hazards with a formalized risk management approach by effectively identifying and attempting to mitigate acute and chronic medical risks to manned space flight. This paper describes NASA Glenn Research Center?s (GRC) efforts to develop a systematic methodology to assess the likelihood of in-flight medical conditions. Using a probabilistic approach, medical risks are assessed using well established and accepted biomedical and human performance models in combination with fundamentally observed data that defines the astronauts? physical conditions, environment and activity levels. Two different examples of space flight risk are used to show the versatility of our approach and how it successfully integrates disparate information to provide HRP decision makers with a valuable source of information which is otherwise lacking.

[From the flight of Iu. A. Gagarin to the contemporary piloted space flights and exploration missions].

PubMed

Grigor'ev, A I; Potapov, A N

2011-01-01

The first human flight to space made by Yu. A. Gagarin on April 12, 1961 was a crucial event in the history of cosmonautics that had a tremendous effect on further progress of the human civilization. Gagarin's flight had been prefaced by long and purposeful biomedical researches with the use of diverse bio-objects flown aboard rockets and artificial satellites. Data of these researches drove to the conclusion on the possibility in principle for humans to fly to space. After a series of early flights and improvements in the medical support system space missions to the Salyut and Mir station gradually extended to record durations. The foundations of this extension were laid by systemic researches in the fields of space biomedicine and allied sciences. The current ISS system of crew medical care has been successful in maintaining health and performance of cosmonauts as well as in providing the conditions for implementation of flight duties and operations with a broad variety of payloads. The ISS abounds in opportunities of realistic trial of concepts and technologies in preparation for crewed exploration missions. At the same, ground-based simulation of a mission to Mars is a venue for realization of scientific and technological experiments in space biomedicine.

Biochemical imaging of tissues by SIMS for biomedical applications

NASA Astrophysics Data System (ADS)

Lee, Tae Geol; Park, Ji-Won; Shon, Hyun Kyong; Moon, Dae Won; Choi, Won Woo; Li, Kapsok; Chung, Jin Ho

2008-12-01

With the development of optimal surface cleaning techniques by cluster ion beam sputtering, certain applications of SIMS for analyzing cells and tissues have been actively investigated. For this report, we collaborated with bio-medical scientists to study bio-SIMS analyses of skin and cancer tissues for biomedical diagnostics. We pay close attention to the setting up of a routine procedure for preparing tissue specimens and treating the surface before obtaining the bio-SIMS data. Bio-SIMS was used to study two biosystems, skin tissues for understanding the effects of photoaging and colon cancer tissues for insight into the development of new cancer diagnostics for cancer. Time-of-flight SIMS imaging measurements were taken after surface cleaning with cluster ion bombardment by Bi n or C 60 under varying conditions. The imaging capability of bio-SIMS with a spatial resolution of a few microns combined with principal component analysis reveal biologically meaningful information, but the lack of high molecular weight peaks even with cluster ion bombardment was a problem. This, among other problems, shows that discourse with biologists and medical doctors are critical to glean any meaningful information from SIMS mass spectrometric and imaging data. For SIMS to be accepted as a routine, daily analysis tool in biomedical laboratories, various practical sample handling methodology such as surface matrix treatment, including nano-metal particles and metal coating, in addition to cluster sputtering, should be studied.

Autogenic Feedback Training Applications for Man in Space

NASA Technical Reports Server (NTRS)

Cowings, Patricia S.; Wade, Charles E. (Technical Monitor)

1994-01-01

Finding an effective treatment for the motion sickness-like symptoms that occur in space has become a high priority for NASA. This paper reviews the back-round research and procedures of an experiment designed to prevent space motion sickness in shuttle crewmembers. The preventive method used, Autogenic - Feedback Training (AFT) involves training subjects to control voluntarily several of their own physiological responses to environmental stressors. AFT has been used reliably to increase tolerance to motion sickness during around based tests in over 300 men and women under a variety of conditions that induce motion sickness, and preliminary evidence from space suggests that AFT may be an effective treatment for space motion sickness as well. Other applications of AFT described include; (1) a potential treatment for post flight orthostatic intolerance, a serious biomedical problem resulting from long duration exposure to micro-g and (2) improving pilot performance during emergency flying conditions.

KSC-04pd1508

NASA Image and Video Library

2004-07-11

KENNEDY SPACE CENTER, FLA. - Onboard the dive boat at the Life Support Buoy offshore from Key Largo is Marc Reagan, mission lead for the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission. At right is Lt. Scott Sparks, a Navy medical officer. Reagan is also the underwater still photographer. The NEEMO-6 team comprises John Herrington, commander, Tara Ruttley, a biomedical engineer, and astronauts Nick Patrick and Doug Wheelock. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1498

NASA Image and Video Library

2004-07-07

KENNEDY SPACE CENTER, FLA. - Disembarking from the boat in Key Largo are Otto Rutten and Marc Reagan, participating in the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission at the NOAA Aquarius underwater station offshore. Rutten is director for the National Underwater Research Center; Reagan is mission lead. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. The NEEMO-6 team comprises astronaut John Herrington, mission commander, astronauts Doug Wheelock and Nick Patrick, and biomedical engineer Tara Ruttley. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1509

NASA Image and Video Library

2004-07-11

KENNEDY SPACE CENTER, FLA. - In the water offshore from Key Largo, site of the NASA Extreme Environment Mission Operations 6 (NEEMO-6), are (left to right) Bill Todd, project lead, and Marc Reagan, mission lead. Todd and Lucas are also the underwater videographer and still photographer, respectively, for the mission. The NEEMO-6 team comprises John Herrington, commander, Tara Ruttley, a biomedical engineer, and astronauts Nick Patrick and Doug Wheelock. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-05PD-0375

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, a worker inside the Multi-Purpose Logistics Module Raffaello is ready for installation of the Human Research Facility-2 (HRF-2) science rack. Raffaello will fly on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

Telemedicine optoelectronic biomedical data processing system

NASA Astrophysics Data System (ADS)

Prosolovska, Vita V.

2010-08-01

The telemedicine optoelectronic biomedical data processing system is created to share medical information for the control of health rights and timely and rapid response to crisis. The system includes the main blocks: bioprocessor, analog-digital converter biomedical images, optoelectronic module for image processing, optoelectronic module for parallel recording and storage of biomedical imaging and matrix screen display of biomedical images. Rated temporal characteristics of the blocks defined by a particular triggering optoelectronic couple in analog-digital converters and time imaging for matrix screen. The element base for hardware implementation of the developed matrix screen is integrated optoelectronic couples produced by selective epitaxy.

Initial Flight Test of the Production Support Flight Control Computers at NASA Dryden Flight Research Center

NASA Technical Reports Server (NTRS)

Carter, John; Stephenson, Mark

1999-01-01

The NASA Dryden Flight Research Center has completed the initial flight test of a modified set of F/A-18 flight control computers that gives the aircraft a research control law capability. The production support flight control computers (PSFCC) provide an increased capability for flight research in the control law, handling qualities, and flight systems areas. The PSFCC feature a research flight control processor that is "piggybacked" onto the baseline F/A-18 flight control system. This research processor allows for pilot selection of research control law operation in flight. To validate flight operation, a replication of a standard F/A-18 control law was programmed into the research processor and flight-tested over a limited envelope. This paper provides a brief description of the system, summarizes the initial flight test of the PSFCC, and describes future experiments for the PSFCC.

Results of the life sciences DSOs conducted aboard the space shuttle 1981-1986

NASA Technical Reports Server (NTRS)

Bungo, Michael W.; Bagian, Tandi M.; Bowman, Mark A.; Levitan, Barry M.

1987-01-01

Results are presented for a number of life sciences investigations sponsored by the Space Biomedical Research Institute at the NASA Lyndon B. Johnson Space Center and conducted as Detailed Supplementary Objectives (DSOs) on Space Shuttle flights between 1981 and 1986. An introduction and a description of the DSO program are followed by summary reports on the investigations. Reports are grouped into the following disciplines: Biochemistry and Pharmacology, Cardiovascular Effects and Fluid Shifts, Equipment Testing and Experiment Verification, Microbiology, Space Motion Sickness, and Vision. In the appendix, the status of every medical/life science DSO is presented in graphical form, which enables the flight history, the number of subjects tested, and the experiment results to be reviewed at a glance.

Mission Specialist (MS) Thornton rolls DSO 404 strip chart on middeck

NASA Image and Video Library

1983-09-05

STS008-14-378 (30 Aug-5 Sept 1983) --- Astronaut William E. Thornton, a very busy mission specialist conducting a great deal of bio-medical experimentation, checks a prolific roll of data in the mid deck of the Earth-orbiting Space Shuttle Challenger. The electrode on Dr. Thornton’s forehead indicates that his four crewmates were not his only test subjects during the extensive test on this six-day flight.

The Value of Biomedical Simulation Environments to Future Human Space Flight Missions

NASA Technical Reports Server (NTRS)

Mulugeta,Lealem; Myers, Jerry G.; Lewandowski, Beth; Platts, Steven H.

2011-01-01

Mars and NEO missions will expose astronaut to extended durations of reduced reduced gravity, isolation and higher radiation. These new operation conditions pose health risks that are not well understood and perhaps unanticipated. Advanced computational simulation environments can beneficially augment research to predict, assess and mitigate potential hazards to astronaut health. The NASA Digital Astronaut Project (DAP), within the NASA Human Research Program, strives to achieve this goal.

Reduced-gravity environment hardware demonstrations of a prototype miniaturized flow cytometer and companion microfluidic mixing technology.

PubMed

Phipps, William S; Yin, Zhizhong; Bae, Candice; Sharpe, Julia Z; Bishara, Andrew M; Nelson, Emily S; Weaver, Aaron S; Brown, Daniel; McKay, Terri L; Griffin, DeVon; Chan, Eugene Y

2014-11-13

Until recently, astronaut blood samples were collected in-flight, transported to earth on the Space Shuttle, and analyzed in terrestrial laboratories. If humans are to travel beyond low Earth orbit, a transition towards space-ready, point-of-care (POC) testing is required. Such testing needs to be comprehensive, easy to perform in a reduced-gravity environment, and unaffected by the stresses of launch and spaceflight. Countless POC devices have been developed to mimic laboratory scale counterparts, but most have narrow applications and few have demonstrable use in an in-flight, reduced-gravity environment. In fact, demonstrations of biomedical diagnostics in reduced gravity are limited altogether, making component choice and certain logistical challenges difficult to approach when seeking to test new technology. To help fill the void, we are presenting a modular method for the construction and operation of a prototype blood diagnostic device and its associated parabolic flight test rig that meet the standards for flight-testing onboard a parabolic flight, reduced-gravity aircraft. The method first focuses on rig assembly for in-flight, reduced-gravity testing of a flow cytometer and a companion microfluidic mixing chip. Components are adaptable to other designs and some custom components, such as a microvolume sample loader and the micromixer may be of particular interest. The method then shifts focus to flight preparation, by offering guidelines and suggestions to prepare for a successful flight test with regard to user training, development of a standard operating procedure (SOP), and other issues. Finally, in-flight experimental procedures specific to our demonstrations are described.

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

PubMed Central

Bae, Candice; Sharpe, Julia Z.; Bishara, Andrew M.; Nelson, Emily S.; Weaver, Aaron S.; Brown, Daniel; McKay, Terri L.; Griffin, DeVon; Chan, Eugene Y.

2014-01-01

Until recently, astronaut blood samples were collected in-flight, transported to earth on the Space Shuttle, and analyzed in terrestrial laboratories. If humans are to travel beyond low Earth orbit, a transition towards space-ready, point-of-care (POC) testing is required. Such testing needs to be comprehensive, easy to perform in a reduced-gravity environment, and unaffected by the stresses of launch and spaceflight. Countless POC devices have been developed to mimic laboratory scale counterparts, but most have narrow applications and few have demonstrable use in an in-flight, reduced-gravity environment. In fact, demonstrations of biomedical diagnostics in reduced gravity are limited altogether, making component choice and certain logistical challenges difficult to approach when seeking to test new technology. To help fill the void, we are presenting a modular method for the construction and operation of a prototype blood diagnostic device and its associated parabolic flight test rig that meet the standards for flight-testing onboard a parabolic flight, reduced-gravity aircraft. The method first focuses on rig assembly for in-flight, reduced-gravity testing of a flow cytometer and a companion microfluidic mixing chip. Components are adaptable to other designs and some custom components, such as a microvolume sample loader and the micromixer may be of particular interest. The method then shifts focus to flight preparation, by offering guidelines and suggestions to prepare for a successful flight test with regard to user training, development of a standard operating procedure (SOP), and other issues. Finally, in-flight experimental procedures specific to our demonstrations are described. PMID:25490614

Nanoparticles for Biomedical Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nune, Satish K.; Gunda, Padmaja; Thallapally, Praveen K.

2009-11-01

Background: Synthetic nanoparticles are emerging as versatile tools in biomedical applications, particularly in the area of biomedical imaging. Nanoparticles 1 to 100 nm in diameter possess dimensions comparable to biological functional units. Diverse surface chemistries, unique magnetic properties, tunable absorption and emission properties, and recent advances in the synthesis and engineering of various nanoparticles suggest their potential as probes for early detection of diseases such as cancer. Surface functionalization has further expanded the potential of nanoparticles as probes for molecular imaging. Objective: To summarize emerging research of nanoparticles for biomedical imaging with increased selectivity and reduced non-specific uptake with increasedmore » spatial resolution containing stabilizers conjugated with targeting ligands. Methods: This review summarizes recent technological advances in the synthesis of various nanoparticle probes, and surveys methods to improve the targeting of nanoparticles for their applications in biomedical imaging. Conclusion: Structural design of nanomaterials for biomedical imaging continues to expand and diversify. Synthetic methods have aimed to control the size and surface characteristics of nanoparticles to control distribution, half-life and elimination. Although molecular imaging applications using nanoparticles are advancing into clinical applications, challenges such as storage stability and long-term toxicology should continue to be addressed. Keywords: nanoparticle synthesis, surface modification, targeting, molecular imaging, and biomedical imaging.« less

NASA - Human Space Flight

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2006-01-01

The presentation covers five main topical areas. The first is a description of how things work in the microgravity environment such as convection and sedimentation. The second part describes the effects of microgravity on human physiology. This is followed by a description of the hazards of space flight including the environment, the space craft, and the mission. An overview of biomedical research in space, both on shuttle and ISS is the fourth section of the presentation. The presentation concludes with a history of space flight from Ham to ISS. At CART students (11th and 12th graders from Fresno Unified and Clovis Unified) are actively involved in their education. They work in teams to research real world problems and discover original solutions. Students work on projects guided by academic instructors and business partners. They will have access to the latest technology and will be expected to expand their learning environment to include the community. They will focus their studies around a career area (Professional Sciences, Advanced Communications, Engineering and Product Development, or Global Issues).

Training of cosmonauts and astronauts

NASA Technical Reports Server (NTRS)

Gurovskiy, N. N.; Link, M. M.

1975-01-01

The biomedical and preflight training of spacecraft crews is discussed based on a survey of scientific and technical literature in the U.S. and U.S.S.R. Experience gained from high velocity and high altitude aircraft flights, predictions of human reactions and theoretical models of human adaptation to the new environment of space, and actual spaceflight experience provided scientists and specialists with data from which the state of human health in space could be predicted and life support measures developed.

Translations on USSR Science and Technology, Biomedical and Behavioral Sciences, Number 35.

DTIC Science & Technology

1978-07-14

the course of vital functions. The level thereof at relative rest is about 90 kcal/h and it increases by 6-7 times when performing physical work...and moisture from it. Such a method of heat regulation is ineffective in long-term space flights, when a cosmonaut is subject to intensive physical ...P. Leshchinskaya, and I. S. Cherfus, I. M. Sechenov Yalta Scientific Research Institute of Physical Methods of Treatment and Medical Climatology

Experiment K-6-02. Biomedical, biochemical and morphological alterations of muscle and dense, fibrous connective tissues during 14 days of spaceflight

NASA Technical Reports Server (NTRS)

Vailas, A.; Zernicke, R.; Grindeland, R.; Kaplanski, A.

1990-01-01

Findings on the connective tissue response to short-term space flight (12 days) are discussed. Specifically, data regarding the biochemical, biomechanical and morphological characteristics of selected connective tissues (humerus, vertebral body, tendon and skeletal muscle) of growing rats is given. Results are given concerning the humerus cortical bone, the vertebral bone, nutritional effects on bone biomechanical properties, and soft tense fiber connective tissue response.

The next phase of life-sciences spaceflight research

PubMed Central

Etheridge, Timothy; Nemoto, Kanako; Hashizume, Toko; Mori, Chihiro; Sugimoto, Tomoko; Suzuki, Hiromi; Fukui, Keiji; Yamazaki, Takashi; Higashibata, Akira; Higashitani, Atsushi

2011-01-01

Recently we demonstrated that the effectiveness of RNAi interference (RNAi) for inhibiting gene expression is maintained during spaceflight in the worm Caenorhabditis elegans and argued for the biomedical importance of this finding. We also successfully utilized green fluorescent protein (GFP)-tagged proteins to monitor changes in GPF localization during flight. Here we discuss potential applications of RNAi and GFP in spaceflight studies and the ramifications of these experiments for the future of space life-sciences research. PMID:22446523

Spacelab Life Sciences 1 - Dedicated life sciences mission

NASA Technical Reports Server (NTRS)

Womack, W. D.

1990-01-01

The Spacelab Life Sciences 1 (SLS-1) mission is discussed, and an overview of the SLS-1 Spacelab configuration is shown. Twenty interdisciplinary experiments, planned for this mission, are intended to explore the early stages of human and animal physiological adaptation to space flight conditions. Biomedical and gravitational biology experiments include cardiovascular and cardiopulmonary deconditioning, altered vestibular functions, altered metabolic functions (including altered fluid-electrolyte regulation), muscle atrophy, bone demineralization, decreased red blood cell mass, and altered immunologic responses.

KSC-04pd1507

NASA Image and Video Library

2004-07-11

KENNEDY SPACE CENTER, FLA. - Ready for another dive to the NOAA undersea station Aquarius, offshore from Key Largo, the site of the NASA Extreme Environment Mission Operations 6 (NEEMO-6), are (left to right) Monike Schultz, CB Office lead; Bill Todd, project lead; Marc Reagan, mission lead; and Michele Lucas, OPS planner. Todd and Lucas are also the underwater videographer and still photographer, respectively, for the mission. The NEEMO-6 team comprises John Herrington, commander, Tara Ruttley, a biomedical engineer, and astronauts Nick Patrick and Doug Wheelock. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - Aquarius - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1499

NASA Image and Video Library

2004-07-07

KENNEDY SPACE CENTER, FLA. - After their return from a practice dive at the NOAA Aquarius underwater station offshore at Key Largo, Marc Reagan, John Herrington and Nick Patrick unload dive gear. Herrington is mission commander and Patrick is a member of the crew on the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission. Reagan is mission lead as well as underwater still photographer. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius offshore from Key Largo - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. Other team members are Doug Wheelock and biomedical engineer Tara Ruttley. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

KSC-04pd1500

NASA Image and Video Library

2004-07-07

KENNEDY SPACE CENTER, FLA. - After their return from a practice dive at the NOAA Aquarius underwater station offshore at Key Largo, John Herrington and Tara Ruttley look over their dive gear. Herrington is mission commander and Ruttley, a biomedical engineer, is a member of the crew on the NASA Extreme Environment Mission Operations 6 (NEEMO-6) mission. The NEEMO-6 mission involves exposing an astronaut/scientist crew to a real mission experience in an extreme environment - the NOAA undersea station Aquarius offshore from Key Largo - to prepare for future space flight. Spacewalk-like diving excursions and field-tests on a variety of biomedical equipment are designed to help astronauts living aboard the International Space Station. Other team members are astronauts Doug Wheelock and Nick Patrick. To prepare for their 10-day stay, the team had dive training twice a day at the Life Support Buoy, anchored above Aquarius.

Biomedical technology transfer: Applications of NASA science and technology

NASA Technical Reports Server (NTRS)

1976-01-01

The major efforts of the Stanford Biomedical Applications Team Program at the Stanford University School of Medicine for the period from October 1, 1975 to September 31, 1976 are covered. A completed EMG biotelemetry system which monitors the physiological signals of man and animals in space related research is discussed. The results of a pilot study involving lower body negative pressure testing in cardiac patients has been completed as well as the design and construction of a new leg negative pressure unit for evaluating heart patients. This technology utilizes vacuum chambers to stress the cardiovascular system during space flight. Laboratory tests of an intracranial pressure transducer, have been conducted. Extremely stable long term data using capacative pressure sensors has lead to the order of commercially manufactured monitoring systems base. Projects involving commercialization are: flexible medical electrodes, an echocardioscope, a miniature biotelemetry system, and an on-line ventricular contour detector.

The biomedical challenges of space flight

NASA Technical Reports Server (NTRS)

Williams, David R.

2003-01-01

Space medicine has evolved considerably through past U.S. missions. It has been proven that humans can live and work in space for long durations and that humans are integral to mission success. The space medicine program of the National Aeronautics and Space Administration (NASA) looks toward future long-duration missions. Its goal is to overcome the biomedical challenges associated with maintaining the safety, health, and optimum performance of astronauts and cosmonauts. This program investigates the health effects of adaptation to microgravity: the nature of their pathologies, the effects of microgravity on pathophysiology, and the alterations in pharmacodynamics and treatment. A critical capability in performing research is the monitoring of the health of all astronauts and of the spacecraft environment. These data support the evidence-based approach to space medicine, incorporating past studies of microgravity-related conditions and their terrestrial counterparts. This comprehensive approach will enable safe and effective exploration beyond low Earth orbit.

Multidimensional Processing and Visual Rendering of Complex 3D Biomedical Images

NASA Technical Reports Server (NTRS)

Sams, Clarence F.

2016-01-01

The proposed technology uses advanced image analysis techniques to maximize the resolution and utility of medical imaging methods being used during spaceflight. We utilize COTS technology for medical imaging, but our applications require higher resolution assessment of the medical images than is routinely applied with nominal system software. By leveraging advanced data reduction and multidimensional imaging techniques utilized in analysis of Planetary Sciences and Cell Biology imaging, it is possible to significantly increase the information extracted from the onboard biomedical imaging systems. Year 1 focused on application of these techniques to the ocular images collected on ground test subjects and ISS crewmembers. Focus was on the choroidal vasculature and the structure of the optic disc. Methods allowed for increased resolution and quantitation of structural changes enabling detailed assessment of progression over time. These techniques enhance the monitoring and evaluation of crew vision issues during space flight.

Assistance to NASA in biomedical areas of the technology utilization program

NASA Technical Reports Server (NTRS)

Culclasure, D. F.; Eckhardt, L.

1972-01-01

The applications of aerospace technology to biomedical research are reported. The medical institutions participating in the Biomedical Applications Program are listed along with the institutions currently utilizing the services of the Southwest Research Institute Biomedical Applications Team. Significant accomplishments during this period include: ultra-low bandpass amplifier for gastro-intestinal electric potentials; non-encumbering EEG electrode assembly suitable for long term sleep research; accurate cardiac telemetry system for active subjects; warning system for the deaf; tracking cane for the blind; and an improved control mechanism to expand the self-sufficiency of quadriplegics.

Biosputniks: The use by the Soviet Union and Russia of dogs, monkeys and other animals in the exploration of space, 1949-93

NASA Astrophysics Data System (ADS)

Harvey, B.

1993-10-01

The Soviet Union used animals in the exploration of space from 1949 onwards. Russia has continued the use of animals in the exploration of space with the launch on 30 December 1992 of Bion-10 (Cosmos 2229). Animals in the space program is an important theme in the Soviet exploration of space. The use of animals in the exploration of space has four main phases: (1) Suborbital missions 1949-1959; (2) Preparation for man's first flight into space 1960-1; (3) Preparation for man's flight to the Moon 1968-1970; (4) The international biomedical program 1962- . Each is dealt with in turn. The use of animals or biological specimens on board manned orbital space stations is not discussed.

MEDES clinical research facility as a tool to prepare ISSA space flights

NASA Astrophysics Data System (ADS)

Maillet, A.; Traon, A. Pavy-Le

This new multi-disciplinary medical experimentation center provides the ideal scientific, medical and technical environment required for research programs and to prepare international space station Alpha (ISSA) missions, where space and healthcare industries can share their expertise. Different models are available to simulate space flight effects (bed-rest, confinement,…). This is of particular interest for research in Human psychology, physiology, physiopathology and ergonomics, validation of biomedical materials and procedures, testing of drugs, and other healthcare related products. This clinical research facility (CRF) provides valuable services in various fields of Human research requiring healthy volunteers. CRF is widely accessible to national and international, scientific, medical and industrial organisations. Furthermore, users have at their disposal the multi-disciplinary skills of MEDES staff and all MEDES partners on a single site.

14 CFR 25.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Design and Construction Fire Protection § 25.865 Fire protection of flight controls, engine mounts, and other flight structure. Essential flight controls, engine mounts, and other flight structures located in... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fire protection of flight controls, engine...

14 CFR 25.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Design and Construction Fire Protection § 25.865 Fire protection of flight controls, engine mounts, and other flight structure. Essential flight controls, engine mounts, and other flight structures located in... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fire protection of flight controls, engine...

14 CFR 23.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... controls, engine mounts, and other flight structure. Flight controls, engine mounts, and other flight... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Fire protection of flight controls, engine mounts, and other flight structure. 23.865 Section 23.865 Aeronautics and Space FEDERAL AVIATION...

14 CFR 25.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Design and Construction Fire Protection § 25.865 Fire protection of flight controls, engine mounts, and other flight structure. Essential flight controls, engine mounts, and other flight structures located in... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fire protection of flight controls, engine...

14 CFR 23.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... controls, engine mounts, and other flight structure. Flight controls, engine mounts, and other flight... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fire protection of flight controls, engine mounts, and other flight structure. 23.865 Section 23.865 Aeronautics and Space FEDERAL AVIATION...

14 CFR 23.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... controls, engine mounts, and other flight structure. Flight controls, engine mounts, and other flight... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Fire protection of flight controls, engine mounts, and other flight structure. 23.865 Section 23.865 Aeronautics and Space FEDERAL AVIATION...

14 CFR 23.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... controls, engine mounts, and other flight structure. Flight controls, engine mounts, and other flight... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fire protection of flight controls, engine mounts, and other flight structure. 23.865 Section 23.865 Aeronautics and Space FEDERAL AVIATION...

14 CFR 25.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Design and Construction Fire Protection § 25.865 Fire protection of flight controls, engine mounts, and other flight structure. Essential flight controls, engine mounts, and other flight structures located in... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Fire protection of flight controls, engine...

14 CFR 23.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... controls, engine mounts, and other flight structure. Flight controls, engine mounts, and other flight... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fire protection of flight controls, engine mounts, and other flight structure. 23.865 Section 23.865 Aeronautics and Space FEDERAL AVIATION...

14 CFR 25.865 - Fire protection of flight controls, engine mounts, and other flight structure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Design and Construction Fire Protection § 25.865 Fire protection of flight controls, engine mounts, and other flight structure. Essential flight controls, engine mounts, and other flight structures located in... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Fire protection of flight controls, engine...

Microgravity Flight - Accommodating Non-Human Primates

NASA Technical Reports Server (NTRS)

Dalton, Bonnie P.; Searby, Nancy; Ostrach, Louis

1994-01-01

Spacelab Life Sciences-3 (SLS-3) was scheduled to be the first United States man-tended microgravity flight containing Rhesus monkeys. The goal of this flight as in the five untended Russian COSMOS Bion flights and an earlier American Biosatellite flight, was to understand the biomedical and biological effects of a microgravity environment using the non-human primate as human surrogate. The SLS-3/Rhesus Project and COSMOS Primate-BIOS flights all utilized the rhesus monkey, Macaca mulatta. The ultimate objective of all flights with an animal surrogate has been to evaluate and understand biological mechanisms at both the system and cellular level, thus enabling rational effective countermeasures for future long duration human activity under microgravity conditions and enabling technical application to correction of common human physiological problems within earth's gravity, e.g., muscle strength and reloading, osteoporosis, immune deficiency diseases. Hardware developed for the SLS-3/Rhesus Project was the result of a joint effort with the French Centre National d'Etudes Spatiales (CNES) and the United States National Aeronautics and Space Administration (NASA) extending over the last decade. The flight hardware design and development required implementation of sufficient automation to insure flight crew and animal bio-isolation and maintenance with minimal impact to crew activities. A variety of hardware of varying functional capabilities was developed to support the scientific objectives of the original 22 combined French and American experiments, along with 5 Russian co-investigations, including musculoskeletal, metabolic, and behavioral studies. Unique elements of the Rhesus Research Facility (RRF) included separation of waste for daily delivery of urine and fecal samples for metabolic studies and a psychomotor test system for behavioral studies along with monitored food measurement. As in untended flights, telemetry measurements would allow monitoring of thermoregulation, muscular, and cardiac responses to weightlessness. In contrast, the five completed Cosmos/Bion flights, lacked the metabolic samples and behavioral task monitoring, but did facilitate studies of the neurovestibular system during several of the flights.

Bioastronautics: optimizing human performance through research and medical innovations

NASA Technical Reports Server (NTRS)

Williams, David R.

2002-01-01

A strategic use of resources is essential to achieving long-duration space travel and understanding the human physiological changes in space, including the roles of food and nutrition in space. To effectively address the challenges of space flight, the Bioastronautics Initiative, undertaken in 2001, expands extramural collaboration and leverages unique capabilities of the scientific community and the federal government, all the while applying this integrated knowledge to Earth-based problems. Integral to the National Aeronautics and Space Administration's missions in space is the reduction of risk of medical complications, particularly during missions of long duration. Cumulative medical experience and research provide the ability to develop evidence-based medicine for prevention, countermeasures, and treatment modalities for space flight. The early approach applied terrestrial clinical judgment to predict medical problems in space. Space medicine has evolved to an evidence-based approach with the use of biomedical data gathered and lessons learned from previous space flight missions to systematically aid in decision making. This approach led, for example, to the determination of preliminary nutritional requirements for space flight, and it aids in the development of nutrition itself as a countermeasure to support nutritional mitigation of adaptation to space.

Biomedical support of man in space

NASA Astrophysics Data System (ADS)

Pendergast, D. R.; Olszowka, A. J.; Rokitka, M. A.; Farhi, L. E.

In its broadest sense, biomedical support of man in space must not be limited to assisting spacecraft crew during the mission; such support should also ensure that flight personnel be able to perform properly during landing and after leaving the craft. Man has developed mechanisms that allow him to cope with specific stresses in his normal habitat; there is indisputable evidence that, in some cases, the space environment, by relieving these stresses, has also allowed the adaptive mechanisms to lapse, causing serious problems after re-entry. Inflight biomedical support must therefore include means to simulate some of the normal stresses of the Earth environment. In the area of cardiovascular performance, we have come to rely heavily on complex feedback mechanisms to cope with two stresses, often combined: postural changes, which alter the body axis along which gravitational acceleration acts, and physical exercise, which increases the total load on the system. Unless the appropriate responses are reinforced continuously during flight, crew members may be incapacitated upon return. The first step in the support process must be a study of the way in which changes in g, even of short duration, affect these responses. In particular we should learn more about effects of g on the "on" and "off" dynamics, using a variety of approaches: increased acceleration on one hand at recumbency, immersion, lower body positive pressure, and other means of simulating some of the effects of low g, on the other. Once we understand this, we will have to determine the minimal exposure dose required to maintain the response mechanisms. Finally, we shall have to design stresses that simulate Earth environment and can be imposed in the space vehicle. Some of the information is already at hand; we know that several aspects of the response to exercise are affected by posture. Results from a current series of studies on the kinetics of tilt and on the dynamics of readjustment to exercise in different postures will be presented and discussed.

Summer Biomedical Engineering Institute 1972

NASA Technical Reports Server (NTRS)

Deloatch, E. M.

1973-01-01

The five problems studied for biomedical applications of NASA technology are reported. The studies reported are: design modification of electrophoretic equipment, operating room environment control, hematological viscometry, handling system for iridium, and indirect blood pressure measuring device.

Selected Flight Test Results for Online Learning Neural Network-Based Flight Control System

NASA Technical Reports Server (NTRS)

Williams-Hayes, Peggy S.

2004-01-01

The NASA F-15 Intelligent Flight Control System project team developed a series of flight control concepts designed to demonstrate neural network-based adaptive controller benefits, with the objective to develop and flight-test control systems using neural network technology to optimize aircraft performance under nominal conditions and stabilize the aircraft under failure conditions. This report presents flight-test results for an adaptive controller using stability and control derivative values from an online learning neural network. A dynamic cell structure neural network is used in conjunction with a real-time parameter identification algorithm to estimate aerodynamic stability and control derivative increments to baseline aerodynamic derivatives in flight. This open-loop flight test set was performed in preparation for a future phase in which the learning neural network and parameter identification algorithm output would provide the flight controller with aerodynamic stability and control derivative updates in near real time. Two flight maneuvers are analyzed - pitch frequency sweep and automated flight-test maneuver designed to optimally excite the parameter identification algorithm in all axes. Frequency responses generated from flight data are compared to those obtained from nonlinear simulation runs. Flight data examination shows that addition of flight-identified aerodynamic derivative increments into the simulation improved aircraft pitch handling qualities.

Biomedical program of the ALTAIR french russian flight onboard the MIR station.

PubMed

Andre-Deshays, C; Haignere, J P; Guell, A; Marsal, O; Suchet, L; Kotovskaya, A; Gratchev, V; Noskin, A; Grigoriev, A

1995-01-01

One year after the achievement of the 2 weeks ANTARES french-russian mission in the MIR station in July 1992, a 22 days ALTAIR mission with a french cosmonaut has been performed in July 1993, making use of the scientific payload remaining on board. Taking benefit of the analysis of the previous mission, the experimental protocols were adapted to refine scientific objectives and gave to the scientists the opportunity to enhance quantitatively and qualitatively their results. The french biomedical program, conducted in close scientific cooperation with IMBP and associated laboratories, was composed of 8 experiments out of which 2 were new with regards to the ANTARES program. In the field of cardio-vascular physiology and fluid regulation, the experiments: ORTHOSTATISME, DIURESE have been renewed and complemented by the TISSU experiment (proposed by a german scientist) and a real-time tele-assistance program using US echography technic and ground support from the french CADMOS support control center located in Toulouse. With respect to neurosciences objectives, to the experiments VIMINAL (cognitive processes) and ILLUSIONS (study of proprioceptives cues), was added the SYNERGIES experiment to analyse the postural adjustments during movement. The IMMUNOLOGIE experiment carried on and the radiobiological experiment BIODOSE ended. Adding the results of the 2 missions ANTARES and ALTAIR, and the data obtained in between onboard with russian cosmonauts, the scientists have received a wealth of physiological data and gained reproducibility and confidence in their results.

Biomedical program of the ALTAÏR french russian flight onboard the MIR station

NASA Astrophysics Data System (ADS)

André-Deshays, C.; Haigneré, J. P.; Guell, A.; Marsal, O.; Suchet, L.; Kotovskaya, A.; Gratchev, V.; Noskin, A.; Grigoriev, A.

One year after the achievemant of the 2 weeks ANTARES french-russian mission in the MIR station in July 1992, a 22 days ALTAÏR mission with a french cosmonaut has been performed in July 1993, making use of the scientific payload remaining on board. Taking benefit of the analysis of the previous mission, the experimental protocols were adapted to refine scientific objectives and gave to the scientists the opportunity to enhance quantitatively and qualitatively their results. The french biomedical program, conducted in close scientific cooperation with IMBP and associated laboratories, was composed of 8 experiments out of which 2 were new with regards to the ANTARES program. In the field of cardio-vascular physiology and fluid regulation, the experiments: ORTHOSTATISME, DIURESE have been renewed and complemented by the TISSU experiment (proposed by a german scientist) and a real-time tele-assistance program using US echography technic and ground support from the french CADMOS support control center located in Toulouse. With respect to neurosciences objectives, to the experiments VIMINAL (cognitive processes) and ILLUSIONS (study of proprioceptives cues), was added the SYNERGIES experiment to analyse the postural adjustements during movement. The IMMUNOLOGIE experiment carried on and the radiobiological experiment BIODOSE ended. Adding the results of the 2 missions ANTARES and ALTAÏR, and the data obtained in between onboard with russian cosmonauts, the scientists have received a wealth of physiological data and gained reproducibility and confidence in their results.

Variations in chemical fingerprints and major flavonoid contents from the leaves of thirty-one accessions of Hibiscus sabdariffa L.

PubMed

Wang, Jin; Cao, Xianshuang; Ferchaud, Vanessa; Qi, Yadong; Jiang, Hao; Tang, Feng; Yue, Yongde; Chin, Kit L

2016-06-01

The leaves of Hibiscus sabdariffa L. have been used as traditional folk medicines for treating high blood pressure and fever. There are many accessions of H. sabdariffa L. throughout the world. To assess the chemical variations of 31 different accessions of H. sabdariffa L., fingerprinting analysis and quantitation of major flavonoids were performed by high-performance liquid chromatography (HPLC). The HPLC method was validated for linearity, sensitivity, precision, repeatability and accuracy. A quadrupole-time-of-flight mass spectrometry (Q-TOF-MS) was applied for the characterization of major compounds. A total of 9 compounds were identified, including 6 flavonoids and 3 phenolic acids. In the fingerprint analysis, similarity analysis (SA) and principal component analysis (PCA) were used to differentiate the 31 accessions of H. sabdariffa L. Based on the results of PCA and SA, the samples No. 15 and 19 appeared much different from the main group. The total content of five flavonoids varied greatly among different accessions, ranging from 3.35 to 23.30 mg/g. Rutin was found to be the dominant compound and the content of rutin could contribute to chemical variations among different accessions. This study was helpful to understand the chemical variations between different accessions of H. sabdariffa L., which could be used for quality control. © 2015 The Authors Biomedical Chromatography Published by John Wiley & Sons Ltd. © 2015 The Authors Biomedical Chromatography Published by John Wiley & Sons Ltd.

Management and analysis of genomic functional and phenotypic controlled annotations to support biomedical investigation and practice.

PubMed

Masseroli, Marco

2007-07-01

The growing available genomic information provides new opportunities for novel research approaches and original biomedical applications that can provide effective data management and analysis support. In fact, integration and comprehensive evaluation of available controlled data can highlight information patterns leading to unveil new biomedical knowledge. Here, we describe Genome Function INtegrated Discover (GFINDer), a Web-accessible three-tier multidatabase system we developed to automatically enrich lists of user-classified genes with several functional and phenotypic controlled annotations, and to statistically evaluate them in order to identify annotation categories significantly over- or underrepresented in each considered gene class. Genomic controlled annotations from Gene Ontology (GO), KEGG, Pfam, InterPro, and Online Mendelian Inheritance in Man (OMIM) were integrated in GFINDer and several categorical tests were implemented for their analysis. A controlled vocabulary of inherited disorder phenotypes was obtained by normalizing and hierarchically structuring disease accompanying signs and symptoms from OMIM Clinical Synopsis sections. GFINDer modular architecture is well suited for further system expansion and for sustaining increasing workload. Testing results showed that GFINDer analyses can highlight gene functional and phenotypic characteristics and differences, demonstrating its value in supporting genomic biomedical approaches aiming at understanding the complex biomolecular mechanisms underlying patho-physiological phenotypes, and in helping the transfer of genomic results to medical practice.

Design and Testing of Flight Control Laws on the RASCAL Research Helicopter

NASA Technical Reports Server (NTRS)

Frost, Chad R.; Hindson, William S.; Moralez. Ernesto, III; Tucker, George E.; Dryfoos, James B.

2001-01-01

Two unique sets of flight control laws were designed, tested and flown on the Army/NASA Rotorcraft Aircrew Systems Concepts Airborne Laboratory (RASCAL) JUH-60A Black Hawk helicopter. The first set of control laws used a simple rate feedback scheme, intended to facilitate the first flight and subsequent flight qualification of the RASCAL research flight control system. The second set of control laws comprised a more sophisticated model-following architecture. Both sets of flight control laws were developed and tested extensively using desktop-to-flight modeling, analysis, and simulation tools. Flight test data matched the model predicted responses well, providing both evidence and confidence that future flight control development for RASCAL will be efficient and accurate.

Payload specialist Robert Cenker after adjusting DSO equipment

NASA Image and Video Library

1986-01-12

61C-05-035 (12-17 Jan 1986) --- Robert J. Cenker, 61-C payload specialist representing RCA, returns a tiny tool to its stowage position after adjusting the inner workings of a device used in one of a number of detailed supplementary objective (DSO) studies for NASA's Space Biomedical Research Institute. The device is a pair of ocular counter-rolling goggles used by U.S. Rep. Bill Nelson (D., Florida), 61-C's other payload specialist aboard the Columbia for this five-day flight.

Hungarian space research 1981-1985: Lectures and review articles

NASA Technical Reports Server (NTRS)

Benko, G. (Editor)

1986-01-01

This monograph presents an overview of Hungarian space research from 1981 to 1985. Topics discussed in the original report include the development of space research centers, the flight of the first Hungarian astronaut, Hungarian participation in international space programs such as the Vega/Halley's Comet mission and the BEALUCA materials science experiment, advances in astronomical research, and activities of the Cosmic Geodetic Observatory. Other topics discussed incude space biomedical studies, meteorological applications of space research, satellite communications, and satellite power supply systems.

Astronaut Joseph Kerwin strapped into sleep restraint in crew quarters

NASA Image and Video Library

1973-06-01

Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, is photographed strapped into the sleep restraint in the crew quarters of the Orbital Workshop of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is wearing the special cap which contains biomedical instrumentation for the M133 Sleep Monitoring Experiment. The purpose of the M133 experiment is to evaluate quantity and quality of sleep during prolonged space flight by the analysis of electroencephalographic (EEG) and electrooculographic (EOG) activity.

Virtual Glovebox (VGX) Aids Astronauts in Pre-Flight Training

NASA Technical Reports Server (NTRS)

2003-01-01

NASA's Virtual Glovebox (VGX) was developed to allow astronauts on Earth to train for complex biology research tasks in space. The astronauts may reach into the virtual environment, naturally manipulating specimens, tools, equipment, and accessories in a simulated microgravity environment as they would do in space. Such virtual reality technology also provides engineers and space operations staff with rapid prototyping, planning, and human performance modeling capabilities. Other Earth based applications being explored for this technology include biomedical procedural training and training for disarming bio-terrorism weapons.

Space Shuttle Project

NASA Image and Video Library

1992-01-22

Onboard Space Shuttle Discovery (STS-42) the seven crewmembers pose for a traditional in-space portrait in the shirt-sleeve environment of the International Microgravity Laboratory (IML-1) science module in the Shuttle's cargo bay. Pictured are (clockwise from top),Commander Ronald J. Grabe, payload commander Norman E. Thagard, payload specialist Roberta L. Bondar; mission specialists William F. Readdy and David C. Hilmers; pilot Stephen S. Oswald and payload specialist Ulf Merbold. The rotating chair, used often in biomedical tests on the eight-day flight, is in center frame.

STS-118 Ascent/Entry Flight Control Team in White Flight Control Room (WFCR) with Flight Director Steve Stitch

NASA Image and Video Library

2007-07-20

JSC2007-E-41011 (20 July 2007) --- STS-118 Ascent/Entry flight control team pose for a group portrait in the space shuttle flight control room of Houston's Mission Control Center (MCC). Flight director Steve Stich (center right) and astronaut Tony Antonelli, spacecraft communicator (CAPCOM), hold the STS-118 mission logo.

Selected Flight Test Results for Online Learning Neural Network-Based Flight Control System

NASA Technical Reports Server (NTRS)

Williams, Peggy S.

2004-01-01

The NASA F-15 Intelligent Flight Control System project team has developed a series of flight control concepts designed to demonstrate the benefits of a neural network-based adaptive controller. The objective of the team is to develop and flight-test control systems that use neural network technology to optimize the performance of the aircraft under nominal conditions as well as stabilize the aircraft under failure conditions. Failure conditions include locked or failed control surfaces as well as unforeseen damage that might occur to the aircraft in flight. This report presents flight-test results for an adaptive controller using stability and control derivative values from an online learning neural network. A dynamic cell structure neural network is used in conjunction with a real-time parameter identification algorithm to estimate aerodynamic stability and control derivative increments to the baseline aerodynamic derivatives in flight. This set of open-loop flight tests was performed in preparation for a future phase of flights in which the learning neural network and parameter identification algorithm output would provide the flight controller with aerodynamic stability and control derivative updates in near real time. Two flight maneuvers are analyzed a pitch frequency sweep and an automated flight-test maneuver designed to optimally excite the parameter identification algorithm in all axes. Frequency responses generated from flight data are compared to those obtained from nonlinear simulation runs. An examination of flight data shows that addition of the flight-identified aerodynamic derivative increments into the simulation improved the pitch handling qualities of the aircraft.

Flight testing and simulation of an F-15 airplane using throttles for flight control

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Maine, Trindel; Wolf, Thomas

1992-01-01

Flight tests and simulation studies using the throttles of an F-15 airplane for emergency flight control have been conducted at the NASA Dryden Flight Research Facility. The airplane and the simulation are capable of extended up-and-away flight, using only throttles for flight path control. Initial simulation results showed that runway landings using manual throttles-only control were difficult, but possible with practice. Manual approaches flown in the airplane were much more difficult, indicating a significant discrepancy between flight and simulation. Analysis of flight data and development of improved simulation models that resolve the discrepancy are discussed. An augmented throttle-only control system that controls bank angle and flight path with appropriate feedback parameters has also been developed, evaluated in simulations, and is planned for flight in the F-15.

Flight demonstration of a self repairing flight control system in a NASA F-15 fighter aircraft

NASA Technical Reports Server (NTRS)

Urnes, James M.; Stewart, James; Eslinger, Robert

1990-01-01

Battle damage causing loss of control capability can compromise mission objectives and even result in aircraft loss. The Self Repairing Flight Control System (SRFCS) flight development program directly addresses this issue with a flight control system design that measures the damage and immediately refines the control system commands to preserve mission potential. The system diagnostics process detects in flight the type of faults that are difficult to isolate post flight, and thus cause excessive ground maintenance time and cost. The control systems of fighter aircraft have the control power and surface displacement to maneuver the aircraft in a very large flight envelope with a wide variation in airspeed and g maneuvering conditions, with surplus force capacity available from each control surface. Digital flight control processors are designed to include built-in status of the control system components, as well as sensor information on aircraft control maneuver commands and response. In the event of failure or loss of a control surface, the SRFCS utilizes this capability to reconfigure control commands to the remaining control surfaces, thus preserving maneuvering response. Correct post-flight repair is the key to low maintainability support costs and high aircraft mission readiness. The SRFCS utilizes the large data base available with digital flight control systems to diagnose faults. Built-in-test data and sensor data are used as inputs to an Onboard Expert System process to accurately identify failed components for post-flight maintenance action. This diagnostic technique has the advantage of functioning during flight, and so is especially useful in identifying intermittent faults that are present only during maneuver g loads or high hydraulic flow requirements. A flight system was developed to test the reconfiguration and onboard maintenance diagnostics concepts on a NASA F-15 fighter aircraft.

Incidence of clinical symptoms during long-duration orbital spaceflight.

PubMed

Crucian, Brian; Babiak-Vazquez, Adriana; Johnston, Smith; Pierson, Duane L; Ott, C Mark; Sams, Clarence

2016-01-01

The environment of spaceflight may elevate an astronaut's clinical risk for specific diseases. The purpose of this study was to derive, as accurately as currently possible, an assessment of in-flight clinical "incidence" data, based on observed clinical symptoms in astronauts on board the International Space Station (ISS). Electronic medical records were examined from 46 long-duration ISS crew members, each serving approximately a 6-month mission on board the ISS, constituting 20.57 total flight years. Incidence for immunological-related adverse health events or relevant clinical symptoms was tabulated in a non-identifiable fashion. Event categories included infectious diseases, allergies, and rashes/hypersensitivities. A subsequent re-evaluation of more notable events, either of prolonged duration or unresponsive to treatment, was performed. For the disease/symptom categories used in this evaluation, the ISS incidence rate was 3.40 events per flight year. Skin rashes were the most reported event (1.12/flight year) followed by upper respiratory symptoms (0.97/flight year) and various other (non-respiratory) infectious processes. During flight, 46% of crew members reported an event deemed "notable". Among the notable events, 40% were classified as rashes/hypersensitivities. Characterization of on-orbit rashes manifested as redness with irritation, and could present on a variety of body locations. Based on reported symptoms, astronauts experience adverse medical events of varying severity during long-duration spaceflights. The data suggests caution, from both a vehicle design and biomedical countermeasures perspective, as space agencies plan for prolonged deep space exploration missions.

An informal analysis of flight control tasks

NASA Technical Reports Server (NTRS)

Andersen, George J.

1991-01-01

Issues important in rotorcraft flight control are discussed. A perceptual description is suggested of what is believed to be the major issues in flight control. When the task is considered of a pilot controlling a helicopter in flight, the task is decomposed in several subtasks. These subtasks include: (1) the control of altitude, (2) the control of speed, (3) the control of heading, (4) the control of orientation, (5) the control of flight over obstacles, and (6) the control of flight to specified positions in the world. The first four subtasks can be considered to be primary control tasks as they are not dependent on any other subtasks. However, the latter two subtasks can be considered hierarchical tasks as they are dependent on other subtasks. For example, the task of flight control over obstacles can be decomposed as a task requiring the control of speed, altitude, and heading. Thus, incorrect control of altitude should result in poor control of flight over an obstacle.

14 CFR 27.151 - Flight controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flight controls. 27.151 Section 27.151... STANDARDS: NORMAL CATEGORY ROTORCRAFT Flight Flight Characteristics § 27.151 Flight controls. (a) Longitudinal, lateral, directional, and collective controls may not exhibit excessive breakout force, friction...

14 CFR 29.151 - Flight controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flight controls. 29.151 Section 29.151... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Flight Flight Characteristics § 29.151 Flight controls. (a) Longitudinal, lateral, directional, and collective controls may not exhibit excessive breakout force, friction...

Web quality control for lectures: Supercourse and Amazon.com.

PubMed

Linkov, Faina; LaPorte, Ronald; Lovalekar, Mita; Dodani, Sunita

2005-12-01

Peer review has been at the corner stone of quality control of the biomedical journals in the past 300 years. With the emergency of the Internet, new models of quality control and peer review are emerging. However, such models are poorly investigated. We would argue that the popular system of quality control used in Amazon.com offers a way to ensure continuous quality improvement in the area of research communications on the Internet. Such system is providing an interesting alternative to the traditional peer review approaches used in the biomedical journals and challenges the traditional paradigms of scientific publishing. This idea is being explored in the context of Supercourse, a library of 2,350 prevention lectures, shared for free by faculty members from over 150 countries. Supercourse is successfully utilizing quality control approaches that are similar to Amazon.com model. Clearly, the existing approaches and emerging alternatives for quality control in scientific communications needs to be assessed scientifically. Rapid explosion of internet technologies could be leveraged to produce better, more cost effective systems for quality control in the biomedical publications and across all sciences.

Taking control: Complementary and alternative medicine in diabetes and cardiovascular disease management.

PubMed

Warren, Narelle; Canaway, Rachel; Unantenne, Nalika; Manderson, Lenore

2013-07-01

The chronicity of chronic disease, and its associated uncertainties and fluctuations in health status, pain and/or discomfort, often leaves those so diagnosed feeling that they have lost control. Treatment can exacerbate this sense of loss of control, as people surrender to the expertise of their biomedical providers and interventions. In principle, self-management aims to return control to the individual, but its promotion is as much motivated by cost-containment as patient autonomy, and is advocated in an environment largely shaped by policy makers and biomedical providers. In this article, we examine how Australians with type 2 diabetes and/or cardiovascular disease supplement medical with complementary and alternative medical (CAM) care. Drawing on in-depth interviews with 69 participants collected in 2009-2010, we illustrate how people rely on medical providers and pharmaceuticals to manage their diabetes, but concurrently consulted with CAM practitioners and used non-biomedical therapies to enhance well-being. In explaining this, participants framed CAM use in the context of reclaiming relative personal and bodily control.

Photonic crystal fibres in biomedical investigations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skibina, Yu S; Tuchin, Valerii V; Beloglazov, V I

2011-04-30

The state of the art in the field of design and study of photonic crystal fibres for biomedical applications is considered and some original results recently obtained by the authors are presented. Optical properties of the fibres that offer prospects of their wide application as biological sensors, 'labs-on-a-chip', and facilities of electromagnetic radiation control in a wide range of wavelengths aimed at designing novel biomedical instrumentation are considered (optical technologies in biophysics and medicine)

Teaching biomedical applications to secondary students.

PubMed

Openshaw, S; Fleisher, A; Ljunggren, C

1999-01-01

Certain aspects of biomedical engineering applications lend themselves well to experimentation that can be done by high school students. This paper describes two experiments done during a six-week summer internship program in which two high school students used electrodes, circuit boards, and computers to mimic a sophisticated heart monitor and also to control a robotic car. Our experience suggests that simple illustrations of complex instrumentation can be effective in introducing adolescents to the biomedical engineering field.

A neural based intelligent flight control system for the NASA F-15 flight research aircraft

NASA Technical Reports Server (NTRS)

Urnes, James M.; Hoy, Stephen E.; Ladage, Robert N.; Stewart, James

1993-01-01

A flight control concept that can identify aircraft stability properties and continually optimize the aircraft flying qualities has been developed by McDonnell Aircraft Company under a contract with the NASA-Dryden Flight Research Facility. This flight concept, termed the Intelligent Flight Control System, utilizes Neural Network technology to identify the host aircraft stability and control properties during flight, and use this information to design on-line the control system feedback gains to provide continuous optimum flight response. This self-repairing capability can provide high performance flight maneuvering response throughout large flight envelopes, such as needed for the National Aerospace Plane. Moreover, achieving this response early in the vehicle's development schedule will save cost.

Flight Test Implementation of a Second Generation Intelligent Flight Control System

NASA Technical Reports Server (NTRS)

Williams-Hayes, Peggy S.

2005-01-01

The NASA F-15 Intelligent Flight Control System project team has developed a series of flight control concepts designed to demonstrate the benefits of a neural network-based adaptive controller. The objective of the team was to develop and flight-test control systems that use neural network technology, to optimize the performance of the aircraft under nominal conditions, and to stabilize the aircraft under failure conditions. Failure conditions include locked or failed control surfaces as well as unforeseen damage that might occur to the aircraft in flight. The Intelligent Flight Control System team is currently in the process of implementing a second generation control scheme, collectively known as Generation 2 or Gen 2, for flight testing on the NASA F-15 aircraft. This report describes the Gen 2 system as implemented by the team for flight test evaluation. Simulation results are shown which describe the experiment to be performed in flight and highlight the ways in which the Gen 2 system meets the defined objectives.

Propulsion system-flight control integration-flight evaluation and technology transition

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Gilyard, Glenn B.; Myers, Lawrence P.

1990-01-01

Integration of propulsion and flight control systems and their optimization offering significant performance improvement are assessed. In particular, research programs conducted by NASA on flight control systems and propulsion system-flight control interactions on the YF-12 and F-15 aircraft are addressed; these programs have demonstrated increased thrust, reduced fuel consumption, increased engine life, and improved aircraft performance. Focus is placed on altitude control, speed-Mach control, integrated controller design, as well as flight control systems and digital electronic engine control. A highly integrated digital electronic control program is analyzed and compared with a performance seeking control program. It is shown that the flight evaluation and demonstration of these technologies have been a key part in the transition of the concepts to production and operational use on a timely basis.

Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

NASA Technical Reports Server (NTRS)

Clarke, Robert; Allen, Michael J.; Dibley, Ryan P.; Gera, Joseph; Hodgkinson, John

2005-01-01

Successful flight-testing of the Active Aeroelastic Wing airplane was completed in March 2005. This program, which started in 1996, was a joint activity sponsored by NASA, Air Force Research Laboratory, and industry contractors. The test program contained two flight test phases conducted in early 2003 and early 2005. During the first phase of flight test, aerodynamic models and load models of the wing control surfaces and wing structure were developed. Design teams built new research control laws for the Active Aeroelastic Wing airplane using these flight-validated models; and throughout the final phase of flight test, these new control laws were demonstrated. The control laws were designed to optimize strategies for moving the wing control surfaces to maximize roll rates in the transonic and supersonic flight regimes. Control surface hinge moments and wing loads were constrained to remain within hydraulic and load limits. This paper describes briefly the flight control system architecture as well as the design approach used by Active Aeroelastic Wing project engineers to develop flight control system gains. Additionally, this paper presents flight test techniques and comparison between flight test results and predictions.

PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm

PubMed Central

Plikus, Maksim V; Zhang, Zina; Chuong, Cheng-Ming

2006-01-01

Background Understanding research activity within any given biomedical field is important. Search outputs generated by MEDLINE/PubMed are not well classified and require lengthy manual citation analysis. Automation of citation analytics can be very useful and timesaving for both novices and experts. Results PubFocus web server automates analysis of MEDLINE/PubMed search queries by enriching them with two widely used human factor-based bibliometric indicators of publication quality: journal impact factor and volume of forward references. In addition to providing basic volumetric statistics, PubFocus also prioritizes citations and evaluates authors' impact on the field of search. PubFocus also analyses presence and occurrence of biomedical key terms within citations by utilizing controlled vocabularies. Conclusion We have developed citations' prioritisation algorithm based on journal impact factor, forward referencing volume, referencing dynamics, and author's contribution level. It can be applied either to the primary set of PubMed search results or to the subsets of these results identified through key terms from controlled biomedical vocabularies and ontologies. NCI (National Cancer Institute) thesaurus and MGD (Mouse Genome Database) mammalian gene orthology have been implemented for key terms analytics. PubFocus provides a scalable platform for the integration of multiple available ontology databases. PubFocus analytics can be adapted for input sources of biomedical citations other than PubMed. PMID:17014720

Flight Validation of a Metrics Driven L(sub 1) Adaptive Control

NASA Technical Reports Server (NTRS)

Dobrokhodov, Vladimir; Kitsios, Ioannis; Kaminer, Isaac; Jones, Kevin D.; Xargay, Enric; Hovakimyan, Naira; Cao, Chengyu; Lizarraga, Mariano I.; Gregory, Irene M.

2008-01-01

The paper addresses initial steps involved in the development and flight implementation of new metrics driven L1 adaptive flight control system. The work concentrates on (i) definition of appropriate control driven metrics that account for the control surface failures; (ii) tailoring recently developed L1 adaptive controller to the design of adaptive flight control systems that explicitly address these metrics in the presence of control surface failures and dynamic changes under adverse flight conditions; (iii) development of a flight control system for implementation of the resulting algorithms onboard of small UAV; and (iv) conducting a comprehensive flight test program that demonstrates performance of the developed adaptive control algorithms in the presence of failures. As the initial milestone the paper concentrates on the adaptive flight system setup and initial efforts addressing the ability of a commercial off-the-shelf AP with and without adaptive augmentation to recover from control surface failures.

Engineered, thermoresponsive, magnetic nanocarriers of oligo(ethylene glycol)-methacrylate-based biopolymers

NASA Astrophysics Data System (ADS)

McCallister, Thomas; Gidney, Elwood; Adams, Devin; Diercks, David R.; Ghosh, Santaneel

2014-11-01

Engineered magnetic nanocarriers offer attractive options for implementing novel therapeutic solutions in biomedical research; however lack of biocompatibility and external tunability have prevented a biomedical breakthrough. Here we report multifunctional, magnetic nanospheres with tailored size, volumetric transition range, and magnetic properties based on biocompatible, thermo-responsive oligo(ethylene glycol) methacrylate biopolymers. Precise control of the nanosphere size in the range 100-300 nm, coupled with a higher and broader volumetric transition range (32-42 °C), is ideal for various biomedical applications. More importantly, super-paramagnetic behavior of the nanocarriers, even after polymer shell shrinkage, indicates stable and easily controllable loss mechanisms under exposure to an ac magnetic field.

Nonclassical Flight Control for Unhealthy Aircraft

NASA Technical Reports Server (NTRS)

Lu, Ping

1997-01-01

This research set out to investigate flight control of aircraft which has sustained damage in regular flight control effectors, due to jammed control surfaces or complete loss of hydraulic power. It is recognized that in such an extremely difficult situation unconventional measures may need to be taken to regain control and stability of the aircraft. Propulsion controlled aircraft (PCA) concept, initiated at the NASA Dryden Flight Research Center. represents a ground-breaking effort in this direction. In this approach, the engine is used as the only flight control effector in the rare event of complete loss of normal flight control system. Studies and flight testing conducted at NASA Dryden have confirmed the feasibility of the PCA concept. During the course of this research (March 98, 1997 to November 30, 1997), a comparative study has been done using the full nonlinear model of an F-18 aircraft. Linear controllers and nonlinear controllers based on a nonlinear predictive control method have been designed for normal flight control system and propulsion controlled aircraft. For the healthy aircraft with normal flight control, the study shows that an appropriately designed linear controller can perform as well as a nonlinear controller. On the other hand. when the normal flight control is lost and the engine is the only available means of flight control, a nonlinear PCA controller can significantly increase the size of the recoverable region in which the stability of the unstable aircraft can be attained by using only thrust modulation. The findings and controller design methods have been summarized in an invited paper entitled.

Free-flight investigation of forebody blowing for stability and control

NASA Technical Reports Server (NTRS)

Brandon, Jay M.; Simon, James M.; Owens, D. Bruce; Kiddy, Jason S.

1996-01-01

A free-flight wind-tunnel investigation was conducted on a generic fighter model with forebody pneumatic vortex control for high angle-of-attack directional control. This is believed to be the first flight demonstration of a forebody blowing concept integrated into a closed-loop flight control system for stability augmentation and control. The investigation showed that the static wind tunnel estimates of the yaw control available generally agreed with flight results. The control scheme for the blowing nozzles consisted of an on/off control with a deadband. Controlled flight was obtained for the model using forebody blowing for directional control to beyond 45 deg. angle of attack.

A Piloted Evaluation of Damage Accommodating Flight Control Using a Remotely Piloted Vehicle

NASA Technical Reports Server (NTRS)

Cunningham, Kevin; Cox, David E.; Murri, Daniel G.; Riddick, Stephen E.

2011-01-01

Toward the goal of reducing the fatal accident rate of large transport airplanes due to loss of control, the NASA Aviation Safety Program has conducted research into flight control technologies that can provide resilient control of airplanes under adverse flight conditions, including damage and failure. As part of the safety program s Integrated Resilient Aircraft Control Project, the NASA Airborne Subscale Transport Aircraft Research system was designed to address the challenges associated with the safe and efficient subscale flight testing of research control laws under adverse flight conditions. This paper presents the results of a series of pilot evaluations of several flight control algorithms used during an offset-to-landing task conducted at altitude. The purpose of this investigation was to assess the ability of various flight control technologies to prevent loss of control as stability and control characteristics were degraded. During the course of 8 research flights, data were recorded while one task was repeatedly executed by a single evaluation pilot. Two generic failures, which degraded stability and control characteristics, were simulated inflight for each of the 9 different flight control laws that were tested. The flight control laws included three different adaptive control methodologies, several linear multivariable designs, a linear robust design, a linear stability augmentation system, and a direct open-loop control mode. Based on pilot Cooper-Harper Ratings obtained for this test, the adaptive flight control laws provided the greatest overall benefit for the stability and control degradation scenarios that were considered. Also, all controllers tested provided a significant improvement in handling qualities over the direct open-loop control mode.

[Space experiments on the development of biological systems for the human life].

PubMed

Sychev, V N

2013-01-01

Over the past 22 years, the Institute of Biomedical Problems has stubbornly continued the investigations with higher plants aimed at the development of cultivation technologies suitable for the conditions of space flight. Analysis of the results of 24 plant experiments performed aboard orbital complex MIR and the ISS Russian segment evidenced the ability of higher plants to grow, develop and reproduce inside spacecraft living compartments. Space crops were normal as compared with the laboratory controls. Microbial contamination of the plants was within the normal limits; no pathogen has been detected on plant surfaces. Plants did not change genetically, at least in four space generations. It should be noted that the presence of greenhouse on board the ISS also has a marked positive effect on wellbeing of people living in the close environment and isolation from Earth's biosphere. In the context of the above, the higher plants might become a secure and beneficial part of the life support system for crews on space exploration missions.

Combining control input with flight path data to evaluate pilot performance in transport aircraft.

PubMed

Ebbatson, Matt; Harris, Don; Huddlestone, John; Sears, Rodney

2008-11-01

When deriving an objective assessment of piloting performance from flight data records, it is common to employ metrics which purely evaluate errors in flight path parameters. The adequacy of pilot performance is evaluated from the flight path of the aircraft. However, in large jet transport aircraft these measures may be insensitive and require supplementing with frequency-based measures of control input parameters. Flight path and control input data were collected from pilots undertaking a jet transport aircraft conversion course during a series of symmetric and asymmetric approaches in a flight simulator. The flight path data were analyzed for deviations around the optimum flight path while flying an instrument landing approach. Manipulation of the flight controls was subject to analysis using a series of power spectral density measures. The flight path metrics showed no significant differences in performance between the symmetric and asymmetric approaches. However, control input frequency domain measures revealed that the pilots employed highly different control strategies in the pitch and yaw axes. The results demonstrate that to evaluate pilot performance fully in large aircraft, it is necessary to employ performance metrics targeted at both the outer control loop (flight path) and the inner control loop (flight control) parameters in parallel, evaluating both the product and process of a pilot's performance.

STS-97 flight control team in WFCR - JSC - MCC

NASA Image and Video Library

2000-11-24

JSC2000-07303 (24 November 2000) --- The 30-odd flight controllers supporting the STS-97 entry shift pose for a pre-flight group portrait in the shuttle flight control room in Houston's Mission Control Center (JSC). Entry flight director LeRoy Cain (front center) holds a mission logo.

An Electronic Workshop on the Performance Seeking Control and Propulsion Controlled Aircraft Results of the F-15 Highly Integrated Digital Electronic Control Flight Research Program

NASA Technical Reports Server (NTRS)

Powers, Sheryll Goecke (Compiler)

1995-01-01

Flight research for the F-15 HIDEC (Highly Integrated Digital Electronic Control) program was completed at NASA Dryden Flight Research Center in the fall of 1993. The flight research conducted during the last two years of the HIDEC program included two principal experiments: (1) performance seeking control (PSC), an adaptive, real-time, on-board optimization of engine, inlet, and horizontal tail position on the F-15; and (2) propulsion controlled aircraft (PCA), an augmented flight control system developed for landings as well as up-and-away flight that used only engine thrust (flight controls locked) for flight control. In September 1994, the background details and results of the PSC and PCA experiments were presented in an electronic workshop, accessible through the Dryden World Wide Web (http://www.dfrc.nasa.gov/dryden.html) and as a compact disk.

Advanced transport operating system software upgrade: Flight management/flight controls software description

NASA Technical Reports Server (NTRS)

Clinedinst, Winston C.; Debure, Kelly R.; Dickson, Richard W.; Heaphy, William J.; Parks, Mark A.; Slominski, Christopher J.; Wolverton, David A.

1988-01-01

The Flight Management/Flight Controls (FM/FC) software for the Norden 2 (PDP-11/70M) computer installed on the NASA 737 aircraft is described. The software computes the navigation position estimates, guidance commands, those commands to be issued to the control surfaces to direct the aircraft in flight based on the modes selected on the Advanced Guidance Control System (AGSC) mode panel, and the flight path selected via the Navigation Control/Display Unit (NCDU).

Development and Flight Evaluation of an Emergency Digital Flight Control System Using Only Engine Thrust on an F-15 Airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Maine, Trindel A.; Fullerton, C. Gordon; Webb, Lannie Dean

1996-01-01

A propulsion-controlled aircraft (PCA) system for emergency flight control of aircraft with no flight controls was developed and flight tested on an F-15 aircraft at the NASA Dryden Flight Research Center. The airplane has been flown in a throttles-only manual mode and with an augmented system called PCA in which pilot thumbwheel commands and aircraft feedback parameters were used to drive the throttles. Results from a 36-flight evaluation showed that the PCA system can be used to safety land an airplane that has suffered a major flight control system failure. The PCA system was used to recover from a severe upset condition, descend, and land. Guest pilots have also evaluated the PCA system. This paper describes the principles of throttles-only flight control; a history of loss-of-control accidents; a description of the F-15 aircraft; the PCA system operation, simulation, and flight testing; and the pilot comments.

Flight-determined benefits of integrated flight-propulsion control systems

NASA Technical Reports Server (NTRS)

Stewart, James F.; Burcham, Frank W., Jr.; Gatlin, Donald H.

1992-01-01

Over the last two decades, NASA has conducted several experiments in integrated flight-propulsion control. Benefits have included improved maneuverability; increased thrust, range, and survivability; reduced fuel consumption; and reduced maintenance. This paper presents the basic concepts for control integration, examples of implementation, and benefits. The F-111E experiment integrated the engine and inlet control systems. The YF-12C incorporated an integral control system involving the inlet, autopilot, autothrottle, airdata, navigation, and stability augmentation systems. The F-15 research involved integration of the engine, flight, and inlet control systems. Further extension of the integration included real-time, onboard optimization of engine, inlet, and flight control variables; a self-repairing flight control system; and an engines-only control concept for emergency control. The F-18A aircraft incorporated thrust vectoring integrated with the flight control system to provide enhanced maneuvering at high angles of attack. The flight research programs and the resulting benefits of each program are described.

Linearized aerodynamic and control law models of the X-29A airplane and comparison with flight data

NASA Technical Reports Server (NTRS)

Bosworth, John T.

1992-01-01

Flight control system design and analysis for aircraft rely on mathematical models of the vehicle dynamics. In addition to a six degree of freedom nonlinear simulation, the X-29A flight controls group developed a set of programs that calculate linear perturbation models throughout the X-29A flight envelope. The models include the aerodynamics as well as flight control system dynamics and were used for stability, controllability, and handling qualities analysis. These linear models were compared to flight test results to help provide a safe flight envelope expansion. A description is given of the linear models at three flight conditions and two flight control system modes. The models are presented with a level of detail that would allow the reader to reproduce the linear results if desired. Comparison between the response of the linear model and flight measured responses are presented to demonstrate the strengths and weaknesses of the linear models' ability to predict flight dynamics.

Human Research Program (HRP) Exploration Medical Capability (ExMC) Standing Review Panel (SRP)

NASA Technical Reports Server (NTRS)

Cintron, Nitza; Dutson, Eric; Friedl, Karl; Hyman, William; Jemison, Mae; Klonoff, David

2009-01-01

The SRP believes strongly that regularly performed in-flight crew assessments are needed in order to identify a change in health status before a medical condition becomes clinically apparent. It is this early recognition in change that constitutes the foundation of the "occupational health model" expounded in the HRP Requirements Document as a key component of the HRP risk mitigation strategy that will enable its objective of "prevention and mitigation of human health and performance risks". A regular crew status examination of physiological and clinical performance is needed. This can be accomplished through instrumented monitoring of routine embedded tasks. The SRP recommends addition of a new gap to address this action under Category 3.0 Mitigate the Risk. This new gap is closely associated with Task 4.19 which addresses the lack of adequate biomedical monitoring capabilities for performing periodic clinical status evaluations and contingency medical monitoring. A corollary to these gaps is the critical emphasis on preventive medicine, not only during pre- and post-flight phases of a mission as is the current practice, but continued into the in-flight phases of exploration class missions.

Spacelab

NASA Image and Video Library

1985-04-01

The primary purpose of the Spacelab-3 mission was to conduct materials science experiments in a stable low-gravity environment. In addition, the crew performed research in life sciences, fluid mechanics, atmospheric science, and astronomy. Spacelab-3 was equipped with several new minilabs, special facilities that would be used repeatedly on future flights. Two elaborate crystal growth furnaces, a life support and housing facility for small animals, and two types of apparatus for the study of fluids were evaluated on their inaugural flight. In this photograph, astronaut Don Lind observes the mercuric iodide growth experiment through a microscope at the vapor crystal growth furnace. The goals of this investigation were to grow near-perfect single crystals of mercuric iodide and to gain improved understanding of crystal growth by a vapor process. Mercuric iodide crystals have practical use as sensitive x-ray and gamma-ray detectors, and in portable detector devices for nuclear power plant monitoring, natural resource prospecting, biomedical applications in diagnosis and therapy, and in astronomical instruments. Managed by the Marshall Space Flight Center, Spacelab-3 (STS-51B) was launched aboard the Space Shuttle Orbiter Challenger on April 29, 1985.

Spacelab-3 (STS-51B) Onboard Photograph

NASA Technical Reports Server (NTRS)

1985-01-01

The primary purpose of the Spacelab-3 mission was to conduct materials science experiments in a stable low-gravity environment. In addition, the crew performed research in life sciences, fluid mechanics, atmospheric science, and astronomy. Spacelab-3 was equipped with several new minilabs, special facilities that would be used repeatedly on future flights. Two elaborate crystal growth furnaces, a life support and housing facility for small animals, and two types of apparatus for the study of fluids were evaluated on their inaugural flight. In this photograph, astronaut Don Lind observes the mercuric iodide growth experiment through a microscope at the vapor crystal growth furnace. The goals of this investigation were to grow near-perfect single crystals of mercuric iodide and to gain improved understanding of crystal growth by a vapor process. Mercuric iodide crystals have practical use as sensitive x-ray and gamma-ray detectors, and in portable detector devices for nuclear power plant monitoring, natural resource prospecting, biomedical applications in diagnosis and therapy, and in astronomical instruments. Managed by the Marshall Space Flight Center, Spacelab-3 (STS-51B) was launched aboard the Space Shuttle Orbiter Challenger on April 29, 1985.

Experience with synchronous and asynchronous digital control systems. [for flight

NASA Technical Reports Server (NTRS)

Regenie, Victoria A.; Chacon, Claude V.; Lock, Wilton P.

1986-01-01

Flight control systems have undergone a revolution since the days of simple mechanical linkages; presently the most advanced systems are full-authority, full-time digital systems controlling unstable aircraft. With the use of advanced control systems, the aerodynamic design can incorporate features that allow greater performance and fuel savings, as can be seen on the new Airbus design and advanced tactical fighter concepts. These advanced aircraft will be and are relying on the flight control system to provide the stability and handling qualities required for safe flight and to allow the pilot to control the aircraft. Various design philosophies have been proposed and followed to investigate system architectures for these advanced flight control systems. One major area of discussion is whether a multichannel digital control system should be synchronous or asynchronous. This paper addressed the flight experience at the Dryden Flight Research Facility of NASA's Ames Research Center with both synchronous and asynchronous digital flight control systems. Four different flight control systems are evaluated against criteria such as software reliability, cost increases, and schedule delays.

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Primary flight control. 27.673 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.673 Primary flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Primary flight controls. 29.673 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.673 Primary flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Primary flight controls. 29.673 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.673 Primary flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Primary flight control. 27.673 Section 27... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.673 Primary flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

76 FR 9265 - Special Conditions: Gulfstream Model GVI Airplane; Electronic Flight Control System: Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

... for transport category airplanes. These design features include an electronic flight control system... Design Features The GVI has an electronic flight control system and no direct coupling from the cockpit...: Gulfstream Model GVI Airplane; Electronic Flight Control System: Control Surface Position Awareness AGENCY...

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.673 Primary flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Primary flight control. 27.673 Section 27...

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.673 Primary flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Primary flight controls. 29.673 Section 29...

STS-119 Flight Control Team in WFCR - Orbit 3 - Flight Director Bryan Lunney

NASA Image and Video Library

2009-03-24

JSC2009-E-061542 (24 March 2009) --- The members of the STS-119 Orbit 3 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA?s Johnson Space Center. Flight director Bryan Lunney (center) near the front.

STS-125 Flight Control Team in WFCR - Orbit 1 - Flight Director Tony Ceccacci

NASA Image and Video Library

2009-05-20

JSC2009-E-120813 (20 May 2009) --- The members of the STS-125 Orbit 1 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Tony Ceccacci holds the STS-125 mission logo.

STS-131 Flight Control Team in WFCR - Orbit 2 - Flight Director Mike Sarafin

NASA Image and Video Library

2010-04-14

JSC2010-E-051978 (14 April 2010) --- The members of the STS-131 Orbit 2 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Mike Sarafin holds the STS-131 mission logo.

STS-131 Flight Control Team in WFCR - Planning - Flight Director: Ginger Kerrick

NASA Image and Video Library

2010-04-12

JSC2010-E-050902 (12 April 2010) --- The members of the STS-131 Planning flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Ginger Kerrick (center) is visible on the second row.

Development and Flight Test of an Augmented Thrust-Only Flight Control System on an MD-11 Transport Airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Maine, Trindel A.; Burken, John J.; Pappas, Drew

1996-01-01

An emergency flight control system using only engine thrust, called Propulsion-Controlled Aircraft (PCA), has been developed and flight tested on an MD-11 airplane. In this thrust-only control system, pilot flight path and track commands and aircraft feedback parameters are used to control the throttles. The PCA system was installed on the MD-11 airplane using software modifications to existing computers. Flight test results show that the PCA system can be used to fly to an airport and safely land a transport airplane with an inoperative flight control system. In up-and-away operation, the PCA system served as an acceptable autopilot capable of extended flight over a range of speeds and altitudes. The PCA approaches, go-arounds, and three landings without the use of any non-nal flight controls have been demonstrated, including instrument landing system-coupled hands-off landings. The PCA operation was used to recover from an upset condition. In addition, PCA was tested at altitude with all three hydraulic systems turned off. This paper reviews the principles of throttles-only flight control; describes the MD-11 airplane and systems; and discusses PCA system development, operation, flight testing, and pilot comments.

STS-125 Flight Controllers on Console - (Orbit Shift 2). Flight Director: Richard LaBrode

NASA Image and Video Library

2009-05-12

JSC2009-E-119382 (12 May 2009) --- Flight director Rick LaBrode monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-125 flight day two activities. Flight director Chris Edelen is at right.

Flight Approach to Adaptive Control Research

NASA Technical Reports Server (NTRS)

Pavlock, Kate Maureen; Less, James L.; Larson, David Nils

2011-01-01

The National Aeronautics and Space Administration's Dryden Flight Research Center completed flight testing of adaptive controls research on a full-scale F-18 testbed. The testbed served as a full-scale vehicle to test and validate adaptive flight control research addressing technical challenges involved with reducing risk to enable safe flight in the presence of adverse conditions such as structural damage or control surface failures. This paper describes the research interface architecture, risk mitigations, flight test approach and lessons learned of adaptive controls research.

ISS-12A.1 Orbit 1 Flight Control Team in FCR-1 with Flight Director Derek Hassmann

NASA Image and Video Library

2006-12-15

JSC2006-E-54411 (15 Dec. 2006) --- The members of the STS-116/12A.1 ISS Orbit 1 flight control team pose for a group portrait in the station flight control room of Houston's Mission Control Center (MCC). Flight director Derek Hassman (center right) holds the STS-116 mission logo. Astronaut Terry W. Virts Jr., spacecraft communicator (CAPCOM), is at center. PHALCON flight controller Scott Stover (center left) holds the P5 truss power reconfiguration logo.

Preliminary Flight Results of a Fly-by-throttle Emergency Flight Control System on an F-15 Airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Maine, Trindel A.; Fullerton, C. Gordon; Wells, Edward A.

1993-01-01

A multi-engine aircraft, with some or all of the flight control system inoperative, may use engine thrust for control. NASA Dryden has conducted a study of the capability and techniques for this emergency flight control method for the F-15 airplane. With an augmented control system, engine thrust, along with appropriate feedback parameters, is used to control flightpath and bank angle. Extensive simulation studies were followed by flight tests. The principles of throttles only control, the F-15 airplane, the augmented system, and the flight results including actual landings with throttles-only control are discussed.

L(sub 1) Adaptive Flight Control System: Flight Evaluation and Technology Transition

NASA Technical Reports Server (NTRS)

Xargay, Enric; Hovakimyan, Naira; Dobrokhodov, Vladimir; Kaminer, Isaac; Gregory, Irene M.; Cao, Chengyu

2010-01-01

Certification of adaptive control technologies for both manned and unmanned aircraft represent a major challenge for current Verification and Validation techniques. A (missing) key step towards flight certification of adaptive flight control systems is the definition and development of analysis tools and methods to support Verification and Validation for nonlinear systems, similar to the procedures currently used for linear systems. In this paper, we describe and demonstrate the advantages of L(sub l) adaptive control architectures for closing some of the gaps in certification of adaptive flight control systems, which may facilitate the transition of adaptive control into military and commercial aerospace applications. As illustrative examples, we present the results of a piloted simulation evaluation on the NASA AirSTAR flight test vehicle, and results of an extensive flight test program conducted by the Naval Postgraduate School to demonstrate the advantages of L(sub l) adaptive control as a verifiable robust adaptive flight control system.

Flight Test of an Intelligent Flight-Control System

NASA Technical Reports Server (NTRS)

Davidson, Ron; Bosworth, John T.; Jacobson, Steven R.; Thomson, Michael Pl; Jorgensen, Charles C.

2003-01-01

The F-15 Advanced Controls Technology for Integrated Vehicles (ACTIVE) airplane (see figure) was the test bed for a flight test of an intelligent flight control system (IFCS). This IFCS utilizes a neural network to determine critical stability and control derivatives for a control law, the real-time gains of which are computed by an algorithm that solves the Riccati equation. These derivatives are also used to identify the parameters of a dynamic model of the airplane. The model is used in a model-following portion of the control law, in order to provide specific vehicle handling characteristics. The flight test of the IFCS marks the initiation of the Intelligent Flight Control System Advanced Concept Program (IFCS ACP), which is a collaboration between NASA and Boeing Phantom Works. The goals of the IFCS ACP are to (1) develop the concept of a flight-control system that uses neural-network technology to identify aircraft characteristics to provide optimal aircraft performance, (2) develop a self-training neural network to update estimates of aircraft properties in flight, and (3) demonstrate the aforementioned concepts on the F-15 ACTIVE airplane in flight. The activities of the initial IFCS ACP were divided into three Phases, each devoted to the attainment of a different objective. The objective of Phase I was to develop a pre-trained neural network to store and recall the wind-tunnel-based stability and control derivatives of the vehicle. The objective of Phase II was to develop a neural network that can learn how to adjust the stability and control derivatives to account for failures or modeling deficiencies. The objective of Phase III was to develop a flight control system that uses the neural network outputs as a basis for controlling the aircraft. The flight test of the IFCS was performed in stages. In the first stage, the Phase I version of the pre-trained neural network was flown in a passive mode. The neural network software was running using flight data inputs with the outputs provided to instrumentation only. The IFCS was not used to control the airplane. In another stage of the flight test, the Phase I pre-trained neural network was integrated into a Phase III version of the flight control system. The Phase I pretrained neural network provided realtime stability and control derivatives to a Phase III controller that was based on a stochastic optimal feedforward and feedback technique (SOFFT). This combined Phase I/III system was operated together with the research flight-control system (RFCS) of the F-15 ACTIVE during the flight test. The RFCS enables the pilot to switch quickly from the experimental- research flight mode back to the safe conventional mode. These initial IFCS ACP flight tests were completed in April 1999. The Phase I/III flight test milestone was to demonstrate, across a range of subsonic and supersonic flight conditions, that the pre-trained neural network could be used to supply real-time aerodynamic stability and control derivatives to the closed-loop optimal SOFFT flight controller. Additional objectives attained in the flight test included (1) flight qualification of a neural-network-based control system; (2) the use of a combined neural-network/closed-loop optimal flight-control system to obtain level-one handling qualities; and (3) demonstration, through variation of control gains, that different handling qualities can be achieved by setting new target parameters. In addition, data for the Phase-II (on-line-learning) neural network were collected, during the use of stacked-frequency- sweep excitation, for post-flight analysis. Initial analysis of these data showed the potential for future flight tests that will incorporate the real-time identification and on-line learning aspects of the IFCS.

Miniature Time-of-Flight Mass Spectrometer

NASA Technical Reports Server (NTRS)

Potember, Richard S.

1999-01-01

Major advances must occur to protect astronauts from prolonged periods in near-zero gravity and high radiation associated with extended space travel. The dangers of living in space must be thoroughly understood and methods developed to reverse those effects that cannot be avoided. Six of the seven research teams established by the National Space Biomedical Research Institute (NSBRI) are studying biomedical factors for prolonged space travel to deliver effective countermeasures. To develop effective countermeasures, each of these teams require identification of and quantitation of complex pharmacological, hormonal, and growth factor compounds (biomarkers) in humans and in experimental animals to develop an in-depth knowledge of the physiological changes associated with space travel. At present, identification of each biomarker requires a separate protocol. Many of these procedures are complicated and the identification of each biomarker requires a separate protocol and associated laboratory equipment. To carry all of this equipment and chemicals on a spacecraft would require a complex clinical laboratory; and it would occupy much of the astronauts time. What is needed is a small, efficient, broadband medical diagnostic instrument to rapidly identify important biomarkers for human space exploration. The Miniature Time-Of- Flight Mass Spectrometer Project in the Technology Development Team is developing a small, high resolution, time-of-flight mass spectrometer (TOFMS) to quantitatively measure biomarkers for human space exploration. Virtues of the JHU/APL TOFMS technologies reside in the promise for a small (less than one cubic ft), lightweight (less than 5 kg), low-power (less than 50 watts), rugged device that can be used continuously with advanced signal processing diagnostics. To date, the JHU/APL program has demonstrated mass capability from under 100 to beyond 10,000 atomic mass units (amu) in a very small, low power prototype for biological analysis. Further, the electronic nature of the TOFMS output makes it ideal for rapid telemetry to earth for in-depth analysis by ground support teams.

Experience with synchronous and asynchronous digital control systems

NASA Technical Reports Server (NTRS)

Regenie, V. A.; Chacon, C. V.; Lock, W. P.

1986-01-01

Flight control systems have undergone a revolution since the days of simple mechanical linkages; presently the most advanced systems are full-authority, full-time digital systems controlling unstable aircraft. With the use of advanced control systems, the aerodynamic design can incorporate features that allow greater performance and fuel savings, as can be seen on the new Airbus design and advanced tactical fighter concepts. These advanced aircraft will be and are relying on the flight control system to provide the stability and handling qualities required for safe flight and to allow the pilot to control the aircraft. Various design philosophies have been proposed and followed to investigate system architectures for these advanced flight control systems. One major area of discussion is whether a multichannel digital control system should be synchronous or asynchronous. This paper addressed the flight experience at the Dryden Flight Research Facility of NASA's Ames Research Center with both synchronous and asynchronous digital flight control systems. Four different flight control systems are evaluated against criteria such as software reliability, cost increases, and schedule delays.

An Overview of Controls and Flying Qualities Technology on the F/A-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Pahle, Joseph W.; Wichman, Keith D.; Foster, John V.; Bundick, W. Thomas

1996-01-01

The NASA F/A-18 High Alpha Research Vehicle (HARV) has been the flight test bed of a focused technology effort to significantly increase maneuvering capability at high angles of attack. Development and flight test of control law design methodologies, handling qualities metrics, performance guidelines, and flight evaluation maneuvers are described. The HARV has been modified to include two research control effectors, thrust vectoring, and actuated forebody strakes in order to provide increased control power at high angles of attack. A research flight control system has been used to provide a flexible, easily modified capability for high-angle-of-attack research controls. Different control law design techniques have been implemented and flight-tested, including eigenstructure assignment, variable gain output feedback, pseudo controls, and model-following. Extensive piloted simulation has been used to develop nonlinear performance guide-lines and handling qualities criteria for high angles of attack. This paper reviews the development and evaluation of technologies useful for high-angle-of-attack control. Design, development, and flight test of the research flight control system, control laws, flying qualities specifications, and flight test maneuvers are described. Flight test results are used to illustrate some of the lessons learned during flight test and handling qualities evaluations.

Manual Manipulation of Engine Throttles for Emergency Flight Control

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Fullerton, C. Gordon; Maine, Trindel A.

2004-01-01

If normal aircraft flight controls are lost, emergency flight control may be attempted using only engines thrust. Collective thrust is used to control flightpath, and differential thrust is used to control bank angle. Flight test and simulation results on many airplanes have shown that pilot manipulation of throttles is usually adequate to maintain up-and-away flight, but is most often not capable of providing safe landings. There are techniques that will improve control and increase the chances of a survivable landing. This paper reviews the principles of throttles-only control (TOC), a history of accidents or incidents in which some or all flight controls were lost, manual TOC results for a wide range of airplanes from simulation and flight, and suggested techniques for flying with throttles only and making a survivable landing.

Flight control actuation system

NASA Technical Reports Server (NTRS)

Wingett, Paul T. (Inventor); Gaines, Louie T. (Inventor); Evans, Paul S. (Inventor); Kern, James I. (Inventor)

2004-01-01

A flight control actuation system comprises a controller, electromechanical actuator and a pneumatic actuator. During normal operation, only the electromechanical actuator is needed to operate a flight control surface. When the electromechanical actuator load level exceeds 40 amps positive, the controller activates the pneumatic actuator to offset electromechanical actuator loads to assist the manipulation of flight control surfaces. The assistance from the pneumatic load assist actuator enables the use of an electromechanical actuator that is smaller in size and mass, requires less power, needs less cooling processes, achieves high output forces and adapts to electrical current variations. The flight control actuation system is adapted for aircraft, spacecraft, missiles, and other flight vehicles, especially flight vehicles that are large in size and travel at high velocities.

Flight control actuation system

NASA Technical Reports Server (NTRS)

Wingett, Paul T. (Inventor); Gaines, Louie T. (Inventor); Evans, Paul S. (Inventor); Kern, James I. (Inventor)

2006-01-01

A flight control actuation system comprises a controller, electromechanical actuator and a pneumatic actuator. During normal operation, only the electromechanical actuator is needed to operate a flight control surface. When the electromechanical actuator load level exceeds 40 amps positive, the controller activates the pneumatic actuator to offset electromechanical actuator loads to assist the manipulation of flight control surfaces. The assistance from the pneumatic load assist actuator enables the use of an electromechanical actuator that is smaller in size and mass, requires less power, needs less cooling processes, achieves high output forces and adapts to electrical current variations. The flight control actuation system is adapted for aircraft, spacecraft, missiles, and other flight vehicles, especially flight vehicles that are large in size and travel at high velocities.

Expedition 13 flight controller on console during mission - Orbit 1, BFCR

NASA Image and Video Library

2006-08-31

JSC2006-E-38926 (31 Aug. 2006) --- Flight director Rick LaBrode discusses Expedition 13 mission activities with another flight controller (out of frame) in the Station (Blue) Flight Control Room in Houston's Mission Control Center.

Life Sciences Data Archive Scientific Development

NASA Technical Reports Server (NTRS)

Buckey, Jay C., Jr.

1995-01-01

The Life Sciences Data Archive will provide scientists, managers and the general public with access to biomedical data collected before, during and after spaceflight. These data are often irreplaceable and represent a major resource from the space program. For these data to be useful, however, they must be presented with enough supporting information, description and detail so that an interested scientist can understand how, when and why the data were collected. The goal of this contract was to provide a scientific consultant to the archival effort at the NASA-Johnson Space Center. This consultant (Jay C. Buckey, Jr., M.D.) is a scientist, who was a co-investigator on both the Spacelab Life Sciences-1 and Spacelab Life Sciences-2 flights. In addition he was an alternate payload specialist for the Spacelab Life Sciences-2 flight. In this role he trained on all the experiments on the flight and so was familiar with the protocols, hardware and goals of all the experiments on the flight. Many of these experiments were flown on both SLS-1 and SLS-2. This background was useful for the archive, since the first mission to be archived was Spacelab Life Sciences-1. Dr. Buckey worked directly with the archive effort to ensure that the parameters, scientific descriptions, protocols and data sets were accurate and useful.

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Primary flight controls. 29.673 Section 29.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Primary flight controls. 29.673 Section 29.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Primary flight control. 27.673 Section 27.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Primary flight control. 27.673 Section 27.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

STS-125 Flight Control Team in WFCR - Orbit 2 - Flight Director Richard LaBrode

NASA Image and Video Library

2009-05-20

JSC2009-E-120845 (20 May 2009) --- The members of the STS-125 Orbit 2 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Rick LaBrode (right) is visible on the front row.

STS-125 Flight Control Team in WFCR - Orbit 3 - Flight Director Paul Dye

NASA Image and Video Library

2009-05-20

JSC2009-E-120846 (20 May 2009) --- The members of the STS-125 Orbit 3 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Paul Dye (center left) is visible on the front row.

STS-131 Flight Control Team in WFCR - Orbit 1 - Flight Director: Richard Jones

NASA Image and Video Library

2010-04-12

JSC2010-E-050680 (12 April 2010) --- The members of the STS-131 Orbit 1 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Richard Jones (second left) is on the front row.

Flight-testing of the self-repairing flight control system using the F-15 highly integrated digital electronic control flight research facility

NASA Technical Reports Server (NTRS)

Stewart, James F.; Shuck, Thomas L.

1990-01-01

Flight tests conducted with the self-repairing flight control system (SRFCS) installed on the NASA F-15 highly integrated digital electronic control aircraft are described. The development leading to the current SRFCS configuration is highlighted. Key objectives of the program are outlined: (1) to flight-evaluate a control reconfiguration strategy with three types of control surface failure; (2) to evaluate a cockpit display that will inform the pilot of the maneuvering capacity of the damage aircraft; and (3) to flight-evaluate the onboard expert system maintenance diagnostics process using representative faults set to occur only under maneuvering conditions. Preliminary flight results addressing the operation of the overall system, as well as the individual technologies, are included.

Mission Control Center (MCC) system specification for the shuttle Orbital Flight Test (OFT) timeframe

NASA Technical Reports Server (NTRS)

1978-01-01

The Mission Control Center Shuttle (MCC) Shuttle Orbital Flight Test (OFT) Data System (OFTDS) provides facilities for flight control and data systems personnel to monitor and control the Shuttle flights from launch (tower clear) to rollout (wheels stopped on runway). It also supports the preparation for flight (flight planning, flight controller and crew training, and integrated vehicle and network testing activities). The MCC Shuttle OFTDS is described in detail. Three major support systems of the OFTDS and the data types and sources of data entering or exiting the MCC were illustrated. These systems are the communication interface system, the data computation complex, and the display and control system.

X-43A Flight Controls

NASA Technical Reports Server (NTRS)

Baumann, Ethan

2006-01-01

A viewgraph presentation detailing X-43A Flight controls at NASA Dryden Flight Research Center is shown. The topics include: 1) NASA Dryden, Overview and current and recent flight test programs; 2) Unmanned Aerial Vehicle Synthetic Aperture Radar (UAVSAR) Program, Program Overview and Platform Precision Autopilot; and 3) Hyper-X Program, Program Overview, X-43A Flight Controls and Flight Results.

Launch Vehicle Manual Steering with Adaptive Augmenting Control In-flight Evaluations Using a Piloted Aircraft

NASA Technical Reports Server (NTRS)

Hanson, Curt

2014-01-01

An adaptive augmenting control algorithm for the Space Launch System has been developed at the Marshall Space Flight Center as part of the launch vehicles baseline flight control system. A prototype version of the SLS flight control software was hosted on a piloted aircraft at the Armstrong Flight Research Center to demonstrate the adaptive controller on a full-scale realistic application in a relevant flight environment. Concerns regarding adverse interactions between the adaptive controller and a proposed manual steering mode were investigated by giving the pilot trajectory deviation cues and pitch rate command authority.

Digital Electronic Engine Control (DEEC) Flight Evaluation in an F-15 Airplane

NASA Technical Reports Server (NTRS)

1984-01-01

Flight evaluation in an F-15 aircraft by digital electronic engine control (DEEC) was investigated. Topics discussed include: system description, F100 engine tests, effects of inlet distortion on static pressure probe, flight tests, digital electronic engine control fault detection and accommodation flight evaluation, flight evaluation of a hydromechanical backup control, augmentor transient capability of an F100 engine, investigation of nozzle instability, real time in flight thrust calculation, and control technology for future aircraft propulsion systems. It is shown that the DEEC system is a powerful and flexible controller for the F100 engine.

The Aircraft Simulation Role in Improving Flight Safety Through Control Room Training

NASA Technical Reports Server (NTRS)

Shy, Karla S.; Hageman, Jacob J.; Le, Jeanette H.; Sitz, Joel (Technical Monitor)

2002-01-01

NASA Dryden Flight Research Center uses its six-degrees-of-freedom (6-DOF) fixed-base simulations for mission control room training to improve flight safety and operations. This concept is applied to numerous flight projects such as the F-18 High Alpha Research Vehicle (HARV), the F-15 Intelligent Flight Control System (IFCS), the X-38 Actuator Control Test (XACT), and X-43A (Hyper-X). The Dryden 6-DOF simulations are typically used through various stages of a project, from design to ground tests. The roles of these simulations have expanded to support control room training, reinforcing flight safety by building control room staff proficiency. Real-time telemetry, radar, and video data are generated from flight vehicle simulation models. These data are used to drive the control room displays. Nominal static values are used to complete information where appropriate. Audio communication is also an integral part of training sessions. This simulation capability is used to train control room personnel and flight crew for nominal missions and emergency situations. Such training sessions are also opportunities to refine flight cards and control room display pages, exercise emergency procedures, and practice control room setup for the day of flight. This paper describes this technology as it is used in the X-43A and F-15 IFCS and XACT projects.

Advanced Transport Operating System (ATOPS) Flight Management/Flight Controls (FM/FC) software description

NASA Technical Reports Server (NTRS)

Wolverton, David A.; Dickson, Richard W.; Clinedinst, Winston C.; Slominski, Christopher J.

1993-01-01

The flight software developed for the Flight Management/Flight Controls (FM/FC) MicroVAX computer used on the Transport Systems Research Vehicle for Advanced Transport Operating Systems (ATOPS) research is described. The FM/FC software computes navigation position estimates, guidance commands, and those commands issued to the control surfaces to direct the aircraft in flight. Various modes of flight are provided for, ranging from computer assisted manual modes to fully automatic modes including automatic landing. A high-level system overview as well as a description of each software module comprising the system is provided. Digital systems diagrams are included for each major flight control component and selected flight management functions.

14 CFR 23.673 - Primary flight controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Primary flight controls. 23.673 Section 23... AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.673 Primary flight controls. Primary flight controls are those used by the pilot for...

14 CFR 23.673 - Primary flight controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Primary flight controls. 23.673 Section 23... AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.673 Primary flight controls. Primary flight controls are those used by the pilot for...

14 CFR 23.673 - Primary flight controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Primary flight controls. 23.673 Section 23... AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.673 Primary flight controls. Primary flight controls are those used by the pilot for...

14 CFR 23.673 - Primary flight controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Primary flight controls. 23.673 Section 23... AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.673 Primary flight controls. Primary flight controls are those used by the pilot for...

14 CFR 23.673 - Primary flight controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Primary flight controls. 23.673 Section 23... AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.673 Primary flight controls. Primary flight controls are those used by the pilot for...

Preliminary flight test results of a fly-by-throttle emergency flight control system on an F-15 airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Maine, Trindel A.; Fullerton, C. G.; Wells, Edward A.

1993-01-01

A multi-engine aircraft, with some or all of the flight control system inoperative, may use engine thrust for control. NASA Dryden has conducted a study of the capability and techniques for this emergency flight control method for the F-15 airplane. With an augmented control system, engine thrust, along with appropriate feedback parameters, is used to control flightpath and bank angle. Extensive simulation studies have been followed by flight tests. This paper discusses the principles of throttles-only control, the F-15 airplane, the augmented system, and the flight results including landing approaches with throttles-only control to within 10 ft of the ground.

Development and flight test experiences with a flight-crucial digital control system

NASA Technical Reports Server (NTRS)

Mackall, Dale A.

1988-01-01

Engineers and scientists in the advanced fighter technology integration (AFTI) F-16 program investigated the integration of emerging technologies into an advanced fighter aircraft. AFTI's three major technologies included: flight-crucial digital control, decoupled aircraft flight control, and integration of avionics, flight control, and pilot displays. In addition to investigating improvements in fighter performance, researchers studied the generic problems confronting the designers of highly integrated flight-crucial digital control. An overview is provided of both the advantages and problems of integration digital control systems. Also, an examination of the specification, design, qualification, and flight test life-cycle phase is provided. An overview is given of the fault-tolerant design, multimoded decoupled flight control laws, and integrated avionics design. The approach to qualifying the software and system designs is discussed, and the effects of design choices on system qualification are highlighted.

Application and flight test of linearizing transformations using measurement feedback to the nonlinear control problem

NASA Technical Reports Server (NTRS)

Antoniewicz, Robert F.; Duke, Eugene L.; Menon, P. K. A.

1991-01-01

The design of nonlinear controllers has relied on the use of detailed aerodynamic and engine models that must be associated with the control law in the flight system implementation. Many of these controllers were applied to vehicle flight path control problems and have attempted to combine both inner- and outer-loop control functions in a single controller. An approach to the nonlinear trajectory control problem is presented. This approach uses linearizing transformations with measurement feedback to eliminate the need for detailed aircraft models in outer-loop control applications. By applying this approach and separating the inner-loop and outer-loop functions two things were achieved: (1) the need for incorporating detailed aerodynamic models in the controller is obviated; and (2) the controller is more easily incorporated into existing aircraft flight control systems. An implementation of the controller is discussed, and this controller is tested on a six degree-of-freedom F-15 simulation and in flight on an F-15 aircraft. Simulation data are presented which validates this approach over a large portion of the F-15 flight envelope. Proof of this concept is provided by flight-test data that closely matches simulation results. Flight-test data are also presented.

Spacecraft Design Thermal Control Subsystem

NASA Technical Reports Server (NTRS)

Miyake, Robert N.

2008-01-01

The Thermal Control Subsystem engineers task is to maintain the temperature of all spacecraft components, subsystems, and the total flight system within specified limits for all flight modes from launch to end-of-mission. In some cases, specific stability and gradient temperature limits will be imposed on flight system elements. The Thermal Control Subsystem of "normal" flight systems, the mass, power, control, and sensing systems mass and power requirements are below 10% of the total flight system resources. In general the thermal control subsystem engineer is involved in all other flight subsystem designs.

STS-125 Flight Controllers on Console - (Orbit Shift 2). Flight Director: Richard LaBrode

NASA Image and Video Library

2009-05-12

JSC2009-E-119390 (12 May 2009) --- Flight director Rick LaBrode monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-125 flight day two activities.

Muscle Feasibility for Cosmos Rhesus

NASA Technical Reports Server (NTRS)

Edgerton, V. Reggie (Principal Investigator); Roland, Roy R.; Hodgson, John A.

1994-01-01

The following tasks were proposed for the Cosmos project: 1) Complete recordings of all preflight candidates during performance of a foot pedal motor control task while in the space capsule mock-up. 2) Complete recordings of all preflight candidates during locomotion and postural tasks. 3) Complete recordings of 24-hour spontaneous cage activity in the two flight monkeys before and after flight and of at least three control (non-flight) monkeys after the flight has been completed. 4) Complete recordings of the foot pedal and motor control tasks during flight and postflight as scheduled. 5) Complete recordings of the vertical drop test pre, during and postflight for the two flight and three control monkeys. 6) Complete recordings of locomotion and posture tests of the two flight monkeys postflight. 7) Complete recordings of locomotion and postural tests of at least three control (non-flight) monkeys during the postflight period. 8) Recalibrate buckles of the two flight and of at least three control monkeys postflight. 9) Complete analysis of the 24 hour EMG recordings of all monkeys. 10) Complete analysis of the foot pedal, locomotor and postural motor control tasks for the two flight and three control monkeys. It was proposed that efforts in the first postflight year be concentrated on the two flight animals and three postflight animals.

Space Station Freedom CHeCS overview. [Crew Health Care System

NASA Technical Reports Server (NTRS)

Boyce, Joey B.

1990-01-01

The current status, progress, and future plans for development of the Crew Health Care System (CHeCS) for the International Space Station Freedom are presented. Essential operational biomedical support requirements for the astronauts, including medical care, environmental habitat monitoring, and countermeasures for the potentially maladaptive physiological effects of space flight will be provided by the CHeCS. Three integral parts will make up the system: a health maintenance facility, an environmental health system, and the exercise countermeasures facility. Details of each of the major systems and their subsystems are presented.

sl2-x3-205

NASA Image and Video Library

2013-09-10

SL2-X3-205 (June 1973) --- Scientist-astronaut Joseph P. Kerwin, Skylab 2 science pilot, is photographed strapped into the sleep restraint in the crew quarters of the Orbital Workshop of the Skylab 1 & 2 space station cluster in Earth orbit. Kerwin is wearing the special cap which contains biomedical instrumentation for the M133 Sleep Monitoring Experiment. The purpose of the M133 experiment is to evaluate quantity and quality of sleep during prolonged space flight by the analysis of electroencephalographic (EEG) and electrooculographic (EOG) activity. Photo credit: NASA

Microgravity: New opportunities to facilitate biotechnology development

NASA Astrophysics Data System (ADS)

Johnson, Terry; Todd, Paul; Stodieck, Louis S.

1996-03-01

New opportunities exist to use the microgravity environment to facilitate biotechnology development. BioServe Space Technologies Center for the Commercial Development of Space offers access to microgravity environments for companies who wish to perform research or develop products in three specific life-science fields: Biomedical and Pharmaceutical Research, Biotechnology and Bioprocessing Research, and Agricultural and Environmental Research. Examples of each include physiological testing of new pharmaceutical countermeasures against symptoms that are exaggerated in space flight, crystallization and testing of novel, precompetitive biopharmaceutical substances in a convection-free environment, and closed life-support system product development.

Flight simulation for flight control computer S/N 0104-1 (ASTP)

NASA Technical Reports Server (NTRS)

1975-01-01

Flight control computer (FCC) 0104-I has been designated the prime unit for the SA-210 launch vehicle. The results of the final flight simulation for FCC S/N 0104-I are documented. These results verify satisfactory implementation of the design release and proper interfacing of the FCC with flight-type control sensor elements and simulated thrust vector control system.

ISS15A Flight Control Team in FCR-1 Orbit 1 - Flight Director Kwatsi Alibaruho

NASA Image and Video Library

2009-03-20

JSC2009-E-060959 (20 March 2009) --- The members of the STS-119/15A ISS Orbit 1 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA’s Johnson Space Center. Flight director Kwatsi Alibaruho (right) is visible on the front row.

STS-131/19A Flight Control Team in FCR-1 - Orbit 1- Flight Director Ron Spencer

NASA Image and Video Library

2010-04-14

JSC2010-E-052008 (14 April 2010) --- The members of the STS-131/19A ISS Orbit 2 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Ron Spencer (right) holds the STS-131 mission logo.

ISS ULF2 Flight Control Team in FCR-1 - Orbit 3 - Flight Director David Korth

NASA Image and Video Library

2009-03-20

JSC2009-E-061164 (20 March 2009) --- The members of the STS-119/15A ISS Orbit 3 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA’s Johnson Space Center. Flight director David Korth (right) is visible on the front row.

STS-131/19A Flight Control Team in FCR-1 - Orbit 1- Flight Director Courtney McMillan

NASA Image and Video Library

2010-04-14

JSC2010-E-052979 (14 April 2010) --- The members of the STS-131/19A ISS Orbit 1 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Courtenay McMillan (center) stands on the front row.

STS-131/19A Flight Control Team in FCR-1 - Orbit 3- Flight Director Ed Van Cise

NASA Image and Video Library

2010-04-14

JSC2010-E-052556 (14 April 2010) --- The members of the STS-131/19A ISS Orbit 3 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Ed Van Cise holds the STS-131 mission logo.

Biomedical Information Dissemination: Alternative Systems.

ERIC Educational Resources Information Center

Farquhar, J. A.

This memorandum is the result of an investigation into the three existing biomedical information services; MEDLARS (Medical Literature Analysis and Retrieval System), the interlibrary loan (ILL) service, and the network of Poison Control Centers. This research is intended to provide an understanding of the structure, quality, and coverage of these…

Southwest Research Institute assistance to NASA in biomedical areas of the technology utilization program

NASA Technical Reports Server (NTRS)

1972-01-01

The problem statements presented relate mostly to research on prosthetic equipment and means of attaching biomedical and electronic devices to the human body. A patent application for a reliable switching element in a patient assist control units is also described.

A Flight Control System Architecture for the NASA AirSTAR Flight Test Infrastructure

NASA Technical Reports Server (NTRS)

Murch, Austin M.

2008-01-01

A flight control system architecture for the NASA AirSTAR infrastructure has been designed to address the challenges associated with safe and efficient flight testing of research control laws in adverse flight conditions. The AirSTAR flight control system provides a flexible framework that enables NASA Aviation Safety Program research objectives, and includes the ability to rapidly integrate and test research control laws, emulate component or sensor failures, inject automated control surface perturbations, and provide a baseline control law for comparison to research control laws and to increase operational efficiency. The current baseline control law uses an angle of attack command augmentation system for the pitch axis and simple stability augmentation for the roll and yaw axes.

Functional integration of vertical flight path and speed control using energy principles

NASA Technical Reports Server (NTRS)

Lambregts, A. A.

1984-01-01

A generalized automatic flight control system was developed which integrates all longitudinal flight path and speed control functions previously provided by a pitch autopilot and autothrottle. In this design, a net thrust command is computed based on total energy demand arising from both flight path and speed targets. The elevator command is computed based on the energy distribution error between flight path and speed. The engine control is configured to produce the commanded net thrust. The design incorporates control strategies and hierarchy to deal systematically and effectively with all aircraft operational requirements, control nonlinearities, and performance limits. Consistent decoupled maneuver control is achieved for all modes and flight conditions without outer loop gain schedules, control law submodes, or control function duplication.

Incidence of clinical symptoms during long-duration orbital spaceflight

PubMed Central

Crucian, Brian; Babiak-Vazquez, Adriana; Johnston, Smith; Pierson, Duane L; Ott, C Mark; Sams, Clarence

2016-01-01

Background The environment of spaceflight may elevate an astronaut’s clinical risk for specific diseases. The purpose of this study was to derive, as accurately as currently possible, an assessment of in-flight clinical “incidence” data, based on observed clinical symptoms in astronauts on board the International Space Station (ISS). Methods Electronic medical records were examined from 46 long-duration ISS crew members, each serving approximately a 6-month mission on board the ISS, constituting 20.57 total flight years. Incidence for immunological-related adverse health events or relevant clinical symptoms was tabulated in a non-identifiable fashion. Event categories included infectious diseases, allergies, and rashes/hypersensitivities. A subsequent re-evaluation of more notable events, either of prolonged duration or unresponsive to treatment, was performed. Results For the disease/symptom categories used in this evaluation, the ISS incidence rate was 3.40 events per flight year. Skin rashes were the most reported event (1.12/flight year) followed by upper respiratory symptoms (0.97/flight year) and various other (non-respiratory) infectious processes. During flight, 46% of crew members reported an event deemed “notable”. Among the notable events, 40% were classified as rashes/hypersensitivities. Characterization of on-orbit rashes manifested as redness with irritation, and could present on a variety of body locations. Conclusion Based on reported symptoms, astronauts experience adverse medical events of varying severity during long-duration spaceflights. The data suggests caution, from both a vehicle design and biomedical countermeasures perspective, as space agencies plan for prolonged deep space exploration missions. PMID:27843335

An overview of integrated flight-propulsion controls flight research on the NASA F-15 research airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Gatlin, Donald H.; Stewart, James F.

1995-01-01

The NASA Dryden Flight Research Center has been conducting integrated flight-propulsion control flight research using the NASA F-15 airplane for the past 12 years. The research began with the digital electronic engine control (DEEC) project, followed by the F100 Engine Model Derivative (EMD). HIDEC (Highly Integrated Digital Electronic Control) became the umbrella name for a series of experiments including: the Advanced Digital Engine Controls System (ADECS), a twin jet acoustics flight experiment, self-repairing flight control system (SRFCS), performance-seeking control (PSC), and propulsion controlled aircraft (PCA). The upcoming F-15 project is ACTIVE (Advanced Control Technology for Integrated Vehicles). This paper provides a brief summary of these activities and provides background for the PCA and PSC papers, and includes a bibliography of all papers and reports from the NASA F-15 project.

Anthropometric considerations for a 4-axis side-arm flight controller

NASA Technical Reports Server (NTRS)

Debellis, W. B.

1986-01-01

A data base on multiaxis side-arm flight controls was generated. The rapid advances in fly-by-light technology, automatic stability systems, and onboard computers have combined to create flexible flight control systems which could reduce the workload imposed on the operator by complex new equipment. This side-arm flight controller combines four controls into one unit and should simplify the pilot's task. However, the use of a multiaxis side-arm flight controller without complete cockpit integration may tend to increase the pilot's workload.

Development and Flight Test of an Emergency Flight Control System Using Only Engine Thrust on an MD-11 Transport Airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Burken, John J.; Maine, Trindel A.; Fullerton, C. Gordon

1997-01-01

An emergency flight control system that uses only engine thrust, called the propulsion-controlled aircraft (PCA) system, was developed and flight tested on an MD-11 airplane. The PCA system is a thrust-only control system, which augments pilot flightpath and track commands with aircraft feedback parameters to control engine thrust. The PCA system was implemented on the MD-11 airplane using only software modifications to existing computers. Results of a 25-hr flight test show that the PCA system can be used to fly to an airport and safely land a transport airplane with an inoperative flight control system. In up-and-away operation, the PCA system served as an acceptable autopilot capable of extended flight over a range of speeds, altitudes, and configurations. PCA approaches, go-arounds, and three landings without the use of any normal flight controls were demonstrated, including ILS-coupled hands-off landings. PCA operation was used to recover from an upset condition. The PCA system was also tested at altitude with all three hydraulic systems turned off. This paper reviews the principles of throttles-only flight control, a history of accidents or incidents in which some or all flight controls were lost, the MD-11 airplane and its systems, PCA system development, operation, flight testing, and pilot comments.

Performance seeking control program overview

NASA Technical Reports Server (NTRS)

Orme, John S.

1995-01-01

The Performance Seeking Control (PSC) program evolved from a series of integrated propulsion-flight control research programs flown at NASA Dryden Flight Research Center (DFRC) on an F-15. The first of these was the Digital Electronic Engine Control (DEEC) program and provided digital engine controls suitable for integration. The DEEC and digital electronic flight control system of the NASA F-15 were ideally suited for integrated controls research. The Advanced Engine Control System (ADECS) program proved that integrated engine and aircraft control could improve overall system performance. The objective of the PSC program was to advance the technology for a fully integrated propulsion flight control system. Whereas ADECS provided single variable control for an average engine, PSC controlled multiple propulsion system variables while adapting to the measured engine performance. PSC was developed as a model-based, adaptive control algorithm and included four optimization modes: minimum fuel flow at constant thrust, minimum turbine temperature at constant thrust, maximum thrust, and minimum thrust. Subsonic and supersonic flight testing were conducted at NASA Dryden covering the four PSC optimization modes and over the full throttle range. Flight testing of the PSC algorithm, conducted in a series of five flight test phases, has been concluded at NASA Dryden covering all four of the PSC optimization modes. Over a three year period and five flight test phases 72 research flights were conducted. The primary objective of flight testing was to exercise each PSC optimization mode and quantify the resulting performance improvements.

Historical aspects of human presence in Space

NASA Astrophysics Data System (ADS)

Harsch, V.

2007-02-01

Purpose: This paper presents the development of human presence in Space from its beginnings. Study hypotheses were based on historical findings on scientific, medical, cultural, and political aspects of manned Space flight due to the different attitudes of Space minded nations and organizations. Impacts of aerospace medicine on the advances of biomedical sciences will be touched upon, as well as the historical development of aviation and Space medical achievements which are described briefly and visions for future developments are given. Methods: An overview was gained by literature-study, archives research and oral history taking. Results: Aviation Medicine evolved parallel to Man's ability to fly. War-triggered advancements in aviation brought mankind to the edge of space-equivalent conditions within a few decades of the first motor-flight, which took place in the USA in 1903 [V. Harsch, Aerospace medicine in Germany: from the very beginnings, Aviation and Space Environment Medicine 71 (2000) 447-450 [1

Veterinary medical considerations for the use of nonhuman primates in space research

NASA Technical Reports Server (NTRS)

Simmonds, R. C.

1977-01-01

The validity of biomedical research using animal subjects is highly dependent on the use of 'normal' and healthy animals. The current costs of research programs dictate that a minimum number of animals and test replicates be used to obtain the desired data. The use of healthy and standardized animals increases the probability of obtaining valid data while also permitting greater economy by reducing the between-individual variation, thus allowing the use of fewer animals. Areas of concern when planning animal payloads include constraints of the flight on candidate species selection, screening for physiological and psychological normalcy, procedures for routine care and quarantine of new animals and those returning from space, ground-based studies to determine experimental protocol, selection of instrumentation, stress during transportation for flight operations, housing and care facilities at launch and recovery sites, and the overall veterinary program.

STS-125 Flight Controllers on Console - (Orbit Shift 2). Flight Director: Richard LaBrode

NASA Image and Video Library

2009-05-12

JSC2009-E-119397 (12 May 2009) --- Flight directors Rick LaBrode (left) and Chris Edelen monitor data at their console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-125 flight day two activities.

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

Investigation of controlled flight into terrain : descriptions of flight paths for selected controlled flight into terrain (CFIT) aircraft accidents, 1985-1997

DOT National Transportation Integrated Search

1999-03-01

This report documents an investigation of the flight paths of 13 selected controlled flight into terrain (CFIT) aircraft accidents that occurred between 1985 and 1997. The Operations Assessment Division (DTS-43) and the Aviation Safety Division (DTS-...

Atmospheric reentry flight test of winged space vehicle

NASA Astrophysics Data System (ADS)

Inatani, Yoshifumi; Akiba, Ryojiro; Hinada, Motoki; Nagatomo, Makoto

A summary of the atmospheric reentry flight experiment of winged space vehicle is presented. The test was conducted and carried out by the Institute of Space and Astronautical Science (ISAS) in Feb. 1992 in Kagoshima Space Center. It is the first Japanese atmospheric reentry flight of the controlled lifting vehicle. A prime objective of the flight is to demonstrate a high speed atmospheric entry flight capability and high-angle-of-attack flight capability in terms of aerodynamics, flight dynamics and flight control of these kind of vehicles. The launch of the winged vehicle was made by balloon and solid propellant rocket booster which was also the first trial in Japan. The vehicle accomplishes the lfight from space-equivalent condition to the atmospheric flight condition where reaction control system (RCS) attitude stabilization and aerodynamic control was used, respectively. In the flight, the vehicle's attitude was measured by both an inertial measurement unit (IMU) and an air data sensor (ADS) which were employed into an auto-pilot flight control loop. After completion of the entry transient flight, the vehicle experienced unexpected instability during the atmospheric decelerating flight; however, it recovered the attitude orientation and completed the transonic flight after that. The latest analysis shows that it is due to the ADS measurement error and the flight control gain scheduling; what happened was all understood. Some details of the test and the brief summary of the current status of the post flight analysis are presented.

Flight Control Laws for NASA's Hyper-X Research Vehicle

NASA Technical Reports Server (NTRS)

Davidson, J.; Lallman, F.; McMinn, J. D.; Martin, J.; Pahle, J.; Stephenson, M.; Selmon, J.; Bose, D.

1999-01-01

The goal of the Hyper-X program is to demonstrate and validate technology for design and performance predictions of hypersonic aircraft with an airframe-integrated supersonic-combustion ramjet propulsion system. Accomplishing this goal requires flight demonstration of a hydrogen-fueled scramjet powered hypersonic aircraft. A key enabling technology for this flight demonstration is flight controls. Closed-loop flight control is required to enable a successful stage separation, to achieve and maintain the design condition during the engine test, and to provide a controlled descent. Before the contract award, NASA developed preliminary flight control laws for the Hyper-X to evaluate the feasibility of the proposed scramjet test sequence and descent trajectory. After the contract award, a Boeing/NASA partnership worked to develop the current control laws. This paper presents a description of the Hyper-X Research Vehicle control law architectures with performance and robustness analyses. Assessments of simulated flight trajectories and stability margin analyses demonstrate that these control laws meet the flight test requirements.

Experimental Validation of L1 Adaptive Control: Rohrs' Counterexample in Flight

NASA Technical Reports Server (NTRS)

Xargay, Enric; Hovakimyan, Naira; Dobrokhodov, Vladimir; Kaminer, Issac; Kitsios, Ioannis; Cao, Chengyu; Gregory, Irene M.; Valavani, Lena

2010-01-01

The paper presents new results on the verification and in-flight validation of an L1 adaptive flight control system, and proposes a general methodology for verification and validation of adaptive flight control algorithms. The proposed framework is based on Rohrs counterexample, a benchmark problem presented in the early 80s to show the limitations of adaptive controllers developed at that time. In this paper, the framework is used to evaluate the performance and robustness characteristics of an L1 adaptive control augmentation loop implemented onboard a small unmanned aerial vehicle. Hardware-in-the-loop simulations and flight test results confirm the ability of the L1 adaptive controller to maintain stability and predictable performance of the closed loop adaptive system in the presence of general (artificially injected) unmodeled dynamics. The results demonstrate the advantages of L1 adaptive control as a verifiable robust adaptive control architecture with the potential of reducing flight control design costs and facilitating the transition of adaptive control into advanced flight control systems.

Microgravity Flight - Accommodating Non-Human Primates

NASA Technical Reports Server (NTRS)

Dalton, Bonnie P.; Searby, Nancy; Ostrach, Louis

1994-01-01

Spacelab Life Sciences-3 (SLS-3) was scheduled to be the first United States man-tended microgravity flight containing Rhesus monkeys. The goal of this flight as in the five untended Russian COSMOS Bion flights and an earlier American Biosatellite flight, was to understand the biomedical and biological effects of a microgravity environment using the non-human primate as human surrogate. The SLS-3/Rhesus Project and COSMOS Primate-BIOS flights all utilized the rhesus monkey Macaca mulatta. The ultimate objective of all flights with an animal surrogate has been to evaluate and understand biological mechanisms at both the system and cellular level, thus enabling rational effective countermeasures for future long duration human activity under microgravity conditions and enabling technical application to correction of common human physiological problems within earth's gravity, e.g., muscle strength and reloading, osteoporosis, immune deficiency diseases. Hardware developed for the SLS-3/Rhesus Project was the result of a joint effort with the French Centre National d'Etudes Spatiales (CNES) and the United States National Aeronautics and Space Administration (NASA) extending over the last decade. The flight hardware design and development required implementation of sufficient automation to insure flight crew and animal bio-isolation and maintenance with minimal impact to crew activities. A variety of hardware of varying functional capabilities was developed to support the scientific objectives of the original 22 combined French and American experiments, along with 5 Russian co-investigations, including musculoskeletal, metabolic, and behavioral studies. Unique elements of the Rhesus Research Facility (RRF) included separation of waste for daily delivery of urine and fecal samples for metabolic studies and a psychomotor test system for behavioral studies along with monitored food measurement. As in untended flights, telemetry measurements would allow monitoring of thermoregulation, muscular, and cardiac responses to weightlessness. In contrast, the five completed Cosmos/Bion flights, lacked the metabolic samples and behavioral task monitoring, but did facilitate studies of the neurovestibular system during several of the flights. The RRF accommodated two adult 8-11 kg rhesus monkeys, while the Russian experiments and hardware were configured for a younger animal in the 44 kg range. Both the American and Russian hardware maintained a controlled environmental system, specifically temperature, humidity, a timed lighting cycle, and had means for providing food and fluids to the animal(s). Crew availability during a Shuttle mission was to be an optimal condition for retrieval and refrigeration of the animal urine samples along with a manual calcein injection which could lead to greater understanding of bone calcium incorporation. A special portable bioisolation glove box was under development to support this aspect of the experiment profile along with the capability of any contingency human intervention. As a result of recent U.S./Russian negotiations, funding for Space Station, and a series of other events, the SLS-3 mission was cancelled and applicable Rhesus Project experiments incorporated into the Russian Bion 11 and 12 missions. A presentation of the RRF and COSMOS/Bion rhesus hardware is presented along with current plans for the hardware.

Microgravity Flight: Accommodating Non-Human Primates

NASA Technical Reports Server (NTRS)

Dalton, Bonnie P.; Searby, Nancy; Ostrach, Louis

1995-01-01

Spacelab Life Sciences-3 (SLS-3) was scheduled to be the first United States man-tended microgravity flight containing Rhesus monkeys. The goal of this flight as in the five untended Russian COSMOS Bion flights and an earlier American Biosatellite flight, was to understand the biomedical and biological effects of a microgravity environment using the non-human primate as human surrogate. The SLS-3/Rhesus Project and COSMOS Primate-BIOS flights all utilized the rhesus monkey, Macaca mulatta. The ultimate objective of all flights with an animal surrogate has been to evaluate and understand biological mechanisms at both the system and cellular level, thus enabling rational effective countermeasures for future long duration human activity under microgravity conditions and enabling technical application to correction of common human physiological problems within earth's gravity, e.g., muscle strength and reloading, osteoporosis, immune deficiency diseases. Hardware developed for the SLS-3/Rhesus Project was the result of a joint effort with the French Centre National d'Etudes Spatiales (CNES) and the United States National Aeronautics and Space Administration (NASA) extending over the last decade. The flight hardware design and development required implementation of sufficient automation to insure flight crew and animal bio-isolation and maintenance with minimal impact to crew activities. A variety of hardware of varying functional capabilities was developed to support the scientific objectives of the original 22 combined French and American experiments, along with 5 Russian co-investigations, including musculoskeletal, metabolic, and behavioral studies. Unique elements of the Rhesus Research Facility (RRF) included separation of waste for daily delivery of urine and fecal samples for metabolic studies and a psychomotor test system for behavioral studies along with monitored food measurement. As in untended flights, telemetry measurements would allow monitoring of thermoregulation, muscular, and cardiac responses to weightlessness. In contrast, the five completed Cosmos/Bion flights, lacked the metabolic samples and behavioral task monitoring, but did facilitate studies of the neurovestibular system during several of the flights. The RRF accommodated two adult 8-11 kg rhesus monkeys, while the Russian experiments and hardware were configured for a younger animal in the 44 kg range. Both the American and Russian hardware maintained a controlled environmental system, specifically temperature, humidity, a timed lighting cycle, and had means for providing food and fluids to the animal(s). Crew availability during a Shuttle mission was to be an optimal condition for retrieval and refrigeration of the animal urine samples along with a manual calcein injection which could lead to greater understanding of bone calcium incorporation. A special portable bioisolation glove box was under development to support this aspect of the experiment profile along with the capability of any contingency human intervention. As a result of recent U.S./Russian negotiations, funding for Space Station, and a series of other events, the SLS-3 mission was cancelled and applicable Rhesus Project experiments incorporated into the Russian Bion 11 and 12 missions. A presentation of the RRF and COSMOS/Bion rhesus hardware is presented along with current plans for the hardware.

Practical aspects of modeling aircraft dynamics from flight data

NASA Technical Reports Server (NTRS)

Iliff, K. W.; Maine, R. E.

1984-01-01

The purpose of parameter estimation, a subset of system identification, is to estimate the coefficients (such as stability and control derivatives) of the aircraft differential equations of motion from sampled measured dynamic responses. In the past, the primary reason for estimating stability and control derivatives from flight tests was to make comparisons with wind tunnel estimates. As aircraft became more complex, and as flight envelopes were expanded to include flight regimes that were not well understood, new requirements for the derivative estimates evolved. For many years, the flight determined derivatives were used in simulations to aid in flight planning and in pilot training. The simulations were particularly important in research flight test programs in which an envelope expansion into new flight regimes was required. Parameter estimation techniques for estimating stability and control derivatives from flight data became more sophisticated to support the flight test programs. As knowledge of these new flight regimes increased, more complex aircraft were flown. Much of this increased complexity was in sophisticated flight control systems. The design and refinement of the control system required higher fidelity simulations than were previously required.

Potential benefits of propulsion and flight control integration for supersonic cruise vehicles

NASA Technical Reports Server (NTRS)

Berry, D. T.; Schweikhard, W. G.

1976-01-01

Typical airframe/propulsion interactions such as Mach/altitude excursions and inlet unstarts are reviewed. The improvements in airplane performance and flight control that can be achieved by improving the interfaces between propulsion and flight control are estimated. A research program to determine the feasibility of integrating propulsion and flight control is described. This program includes analytical studies and YF-12 flight tests.

STS-125 Flight Control Team in WFCR - Ascent/Entry with Flight Director Norman Knight

NASA Image and Video Library

2009-05-21

JSC2009-E-121353 (21 May 2009) --- The members of the STS-125 Ascent and Entry flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Norm Knight (left) and astronaut Gregory H. Johnson, spacecraft communicator (CAPCOM), hold the STS-125 mission logo.

F-16XL ship #1 (#849) during first flight of the Digital Flight Control System (DFCS)

NASA Technical Reports Server (NTRS)

1997-01-01

After completing its first flight with the Digital Flight Control System on December 16, 1997, the F-16XL #1 aircraft began a series of envelope expansion flights. On January 27 and 29, 1998, it successfully completed structural clearance tests, as well as most of the load testing Only flights at Mach 1.05 at 10,000 feet, Mach 1.1 at 15,000 feet, and Mach 1.2 at 20,000 feet remained. During the next flight, on February 4, an instrumentation problem cut short the planned envelope expansion tests. After the problem was corrected, the F-16XL returned to flight status, and on February 18 and 20, flight control and evaluation flights were made. Two more research flights were planned for the following week, but another problem appeared. During the ground start up, project personnel noticed that the leading edge flap moved without being commanded. The Digital Flight Control Computer was sent to the Lockheed-Martin facility at Fort Worth, where the problem was traced to a defective chip in the computer. After it was replaced, the F-16XL #1 flew a highly successful flight controls and handling qualities evaluation flight on March 26, clearing the way for the final tests. The final limited loads expansion flight occurred on March 31, and was fully successful. As a result, the on-site Lockheed-Martin loads engineer cleared the aircraft to Mach 1.8. The remaining two handling qualities and flight control evaluation flights were both made on April 3, 1998. These three flights concluded the flight test portion of the DFCS upgrade.

STS-120 Orbit 2 Flight Control Team Photo

NASA Image and Video Library

2007-10-31

JSC2007-E-095908 (31 Oct. 2007) --- The members of the STS-120 Orbit 2 flight control team pose for a group portrait in the space shuttle flight control room of Houston's Mission Control Center (MCC). Flight director Mike Moses holds the STS-120 mission logo.

Using Engine Thrust for Emergency Flight Control: MD-11 and B-747 Results

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Maine, Trindel A.; Burken, John J.; Bull, John

1998-01-01

With modern digital control systems, using engine thrust for emergency flight control to supplement or replace failed aircraft normal flight controls has become a practical consideration. The NASA Dryden Flight Research Center has developed a propulsion-controlled aircraft (PCA) system in which computer-controlled engine thrust provides emergency flight control. An F-15 and an MD-11 airplane have been landed without using any flight control surfaces. Preliminary studies have also been conducted that show that engines on only one wing can provide some flight control capability if the lateral center of gravity can be shifted toward the side of the airplane that has the operating engine(s). Simulator tests of several airplanes with no flight control surfaces operating and all engines out on the left wing have all shown positive control capability within the available range of lateral center-of-gravity offset. Propulsion-controlled aircraft systems that can operate without modifications to engine control systems, thus allowing PCA technology to be installed on less capable airplanes or at low cost, are also desirable. Further studies have examined simplified 'PCA Lite' and 'PCA Ultralite' concepts in which thrust control is provided by existing systems such as auto-throttles or a combination of existing systems and manual pilot control.

Securely and Flexibly Sharing a Biomedical Data Management System

PubMed Central

Wang, Fusheng; Hussels, Phillip; Liu, Peiya

2011-01-01

Biomedical database systems need not only to address the issues of managing complex data, but also to provide data security and access control to the system. These include not only system level security, but also instance level access control such as access of documents, schemas, or aggregation of information. The latter is becoming more important as multiple users can share a single scientific data management system to conduct their research, while data have to be protected before they are published or IP-protected. This problem is challenging as users’ needs for data security vary dramatically from one application to another, in terms of who to share with, what resources to be shared, and at what access level. We develop a comprehensive data access framework for a biomedical data management system SciPort. SciPort provides fine-grained multi-level space based access control of resources at not only object level (documents and schemas), but also space level (resources set aggregated in a hierarchy way). Furthermore, to simplify the management of users and privileges, customizable role-based user model is developed. The access control is implemented efficiently by integrating access privileges into the backend XML database, thus efficient queries are supported. The secure access approach we take makes it possible for multiple users to share the same biomedical data management system with flexible access management and high data security. PMID:21625285

Flight Test of an Adaptive Controller and Simulated Failure/Damage on the NASA NF-15B

NASA Technical Reports Server (NTRS)

Buschbacher, Mark; Maliska, Heather

2006-01-01

The method of flight-testing the Intelligent Flight Control System (IFCS) Second Generation (Gen-2) project on the NASA NF-15B is herein described. The Gen-2 project objective includes flight-testing a dynamic inversion controller augmented by a direct adaptive neural network to demonstrate performance improvements in the presence of simulated failure/damage. The Gen-2 objectives as implemented on the NASA NF-15B created challenges for software design, structural loading limitations, and flight test operations. Simulated failure/damage is introduced by modifying control surface commands, therefore requiring structural loads measurements. Flight-testing began with the validation of a structural loads model. Flight-testing of the Gen-2 controller continued, using test maneuvers designed in a sequenced approach. Success would clear the new controller with respect to dynamic response, simulated failure/damage, and with adaptation on and off. A handling qualities evaluation was conducted on the capability of the Gen-2 controller to restore aircraft response in the presence of a simulated failure/damage. Control room monitoring of loads sensors, flight dynamics, and controller adaptation, in addition to postflight data comparison to the simulation, ensured a safe methodology of buildup testing. Flight-testing continued without major incident to accomplish the project objectives, successfully uncovering strengths and weaknesses of the Gen-2 control approach in flight.

Software control and system configuration management - A process that works

NASA Technical Reports Server (NTRS)

Petersen, K. L.; Flores, C., Jr.

1983-01-01

A comprehensive software control and system configuration management process for flight-crucial digital control systems of advanced aircraft has been developed and refined to insure efficient flight system development and safe flight operations. Because of the highly complex interactions among the hardware, software, and system elements of state-of-the-art digital flight control system designs, a systems-wide approach to configuration control and management has been used. Specific procedures are implemented to govern discrepancy reporting and reconciliation, software and hardware change control, systems verification and validation testing, and formal documentation requirements. An active and knowledgeable configuration control board reviews and approves all flight system configuration modifications and revalidation tests. This flexible process has proved effective during the development and flight testing of several research aircraft and remotely piloted research vehicles with digital flight control systems that ranged from relatively simple to highly complex, integrated mechanizations.

Software control and system configuration management: A systems-wide approach

NASA Technical Reports Server (NTRS)

Petersen, K. L.; Flores, C., Jr.

1984-01-01

A comprehensive software control and system configuration management process for flight-crucial digital control systems of advanced aircraft has been developed and refined to insure efficient flight system development and safe flight operations. Because of the highly complex interactions among the hardware, software, and system elements of state-of-the-art digital flight control system designs, a systems-wide approach to configuration control and management has been used. Specific procedures are implemented to govern discrepancy reporting and reconciliation, software and hardware change control, systems verification and validation testing, and formal documentation requirements. An active and knowledgeable configuration control board reviews and approves all flight system configuration modifications and revalidation tests. This flexible process has proved effective during the development and flight testing of several research aircraft and remotely piloted research vehicles with digital flight control systems that ranged from relatively simple to highly complex, integrated mechanizations.

Piloted evaluation of an integrated propulsion and flight control simulator

NASA Technical Reports Server (NTRS)

Bright, Michelle M.; Simon, Donald L.

1992-01-01

A piloted evaluation of the integrated flight and propulsion control simulator for advanced integrated propulsion and airframe control design is described. The evaluation will cover control effector gains and deadbands, control effectiveness and control authority, and heads up display functionality. For this evaluation the flight simulator is configured for transition flight using an advanced Short Take-Off and Vertical Landing fighter aircraft model, a simplified high-bypass turbofan engine model, fighter cockpit displays, and pilot effectors. The piloted tasks used for rating displays and control effector gains are described. Pilot comments and simulation results confirm that the display symbology and control gains are very adequate for the transition flight task. Additionally, it is demonstrated that this small-scale, fixed base flight simulator facility can adequately perform a real time, piloted control evaluation.

In-Flight Suppression of an Unstable F/A-18 Structural Mode Using the Space Launch System Adaptive Augmenting Control System

NASA Technical Reports Server (NTRS)

VanZwieten, Tannen S.; Gilligan, Eric T.; Wall, John H.; Miller, Christopher J.; Hanson, Curtis E.; Orr, Jeb S.

2015-01-01

NASA's Space Launch System (SLS) Flight Control System (FCS) includes an Adaptive Augmenting Control (AAC) component which employs a multiplicative gain update law to enhance the performance and robustness of the baseline control system for extreme off-nominal scenarios. The SLS FCS algorithm including AAC has been flight tested utilizing a specially outfitted F/A-18 fighter jet in which the pitch axis control of the aircraft was performed by a Non-linear Dynamic Inversion (NDI) controller, SLS reference models, and the SLS flight software prototype. This paper describes test cases from the research flight campaign in which the fundamental F/A-18 airframe structural mode was identified using post-flight frequency-domain reconstruction, amplified to result in closed loop instability, and suppressed in-flight by the SLS adaptive control system.

Development and Flight Testing of a Neural Network Based Flight Control System on the NF-15B Aircraft

NASA Technical Reports Server (NTRS)

Bomben, Craig R.; Smolka, James W.; Bosworth, John T.; Silliams-Hayes, Peggy S.; Burken, John J.; Larson, Richard R.; Buschbacher, Mark J.; Maliska, Heather A.

2006-01-01

The Intelligent Flight Control System (IFCS) project at the NASA Dryden Flight Research Center, Edwards AFB, CA, has been investigating the use of neural network based adaptive control on a unique NF-15B test aircraft. The IFCS neural network is a software processor that stores measured aircraft response information to dynamically alter flight control gains. In 2006, the neural network was engaged and allowed to learn in real time to dynamically alter the aircraft handling qualities characteristics in the presence of actual aerodynamic failure conditions injected into the aircraft through the flight control system. The use of neural network and similar adaptive technologies in the design of highly fault and damage tolerant flight control systems shows promise in making future aircraft far more survivable than current technology allows. This paper will present the results of the IFCS flight test program conducted at the NASA Dryden Flight Research Center in 2006, with emphasis on challenges encountered and lessons learned.

STS-114 Mission Support - Flight Controllers on Launch Day

NASA Image and Video Library

2005-07-26

Documentation of flight controllers in the White Flight Control Room (WFCR) on STS-114 Launch Day, July 26, 2005. View of Phil Engelauf and Flight Director Paul Hill standing at the Mission Operations Directorate (MOD) console.

STS-125 Flight Controllers on Console During HST Grapple - Orbit 1. Flight Director: Tony Ceccacci

NASA Image and Video Library

2009-05-13

JSC2009-E-119632 (13 May 2009) --- Flight director Tony Ceccacci and astronaut Dan Burbank (background), STS-125 spacecraft communicator (CAPCOM), monitor data at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day three activities.

Attitude control system for a lightweight flapping wing MAV.

PubMed

Tijmons, Sjoerd; Karásek, Matěj; de Croon, G C H E

2018-03-14

Robust attitude control is an essential aspect of research on autonomous flight of flapping wing Micro Air Vehicles. The mechanical solutions by which the necessary control moments are realised come at the price of extra weight and possible loss of aerodynamic efficiency. Stable flight of these vehicles has been shown by several designs using a conventional tail, but also by tailless designs that use active control of the wings. In this study a control mechanism is proposed that provides active control over the wings. The mechanism improves vehicle stability and agility by generation of control moments for roll, pitch and yaw. Its effectiveness is demonstrated by static measurements around all the three axes. Flight test results confirm that the attitude of the test vehicle, including a tail, can be successfully controlled in slow forward flight conditions. Furthermore, the flight envelope is extended with robust hovering and the ability to reverse the flight direction using a small turn space. This capability is very important for autonomous flight capabilities such as obstacle avoidance. Finally, it is demonstrated that the proposed control mechanism allows for tailless hovering flight. © 2018 IOP Publishing Ltd.

Practical Application of a Subscale Transport Aircraft for Flight Research in Control Upset and Failure Conditions

NASA Technical Reports Server (NTRS)

Cunningham, Kevin; Foster, John V.; Morelli, Eugene A.; Murch, Austin M.

2008-01-01

Over the past decade, the goal of reducing the fatal accident rate of large transport aircraft has resulted in research aimed at the problem of aircraft loss-of-control. Starting in 1999, the NASA Aviation Safety Program initiated research that included vehicle dynamics modeling, system health monitoring, and reconfigurable control systems focused on flight regimes beyond the normal flight envelope. In recent years, there has been an increased emphasis on adaptive control technologies for recovery from control upsets or failures including damage scenarios. As part of these efforts, NASA has developed the Airborne Subscale Transport Aircraft Research (AirSTAR) flight facility to allow flight research and validation, and system testing for flight regimes that are considered too risky for full-scale manned transport airplane testing. The AirSTAR facility utilizes dynamically-scaled vehicles that enable the application of subscale flight test results to full scale vehicles. This paper describes the modeling and simulation approach used for AirSTAR vehicles that supports the goals of efficient, low-cost and safe flight research in abnormal flight conditions. Modeling of aerodynamics, controls, and propulsion will be discussed as well as the application of simulation to flight control system development, test planning, risk mitigation, and flight research.

Synthesis and Biomedical Applications of Poly((meth)acrylic acid) Brushes.

PubMed

Qu, Zhenyuan; Xu, Hong; Gu, Hongchen

2015-07-15

Poly((meth)acrylic acid) (P(M)AA) brushes possess a number of distinctive properties that are particularly attractive for biomedical applications. This minireview summarizes recent advances in the synthesis and biomedical applications of P(M)AA brushes and brushes containing P(M)AA segments. First, we review different surface-initiated polymerization (SIP) methods, with a focus on recent progress in the surface-initiated controlled/living radical polymerization (SI-CLRP) techniques used to generate P(M)AA brushes with a tailored structure. Next, we discuss biomolecule immobilization methods for P(M)AA brushes, including physical adsorption, covalent binding, and affinity interactions. Finally, typical biomedical applications of P(M)AA brushes are reviewed, and their performance is discussed based on their unique properties. We conclude that P(M)AA brushes are promising biomaterials, and more potential biomedical applications are expected to emerge with the further development of synthetic techniques and increased understanding of their interactions with biological systems.

STS-125 Entry flight controllers on console with Flight Director Norman Knight

NASA Image and Video Library

2009-05-24

JSC2009-E-121510 (24 May 2009) --- Flight controllers in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center watch the big screens during the landing of Space Shuttle Atlantis (STS-125) at Edwards Air Force Base in California.

STS-125 Entry flight controllers on console with Flight Director Norman Knight

NASA Image and Video Library

2009-05-24

JSC2009-E-121511 (24 May 2009) --- Flight controllers in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center watch the big screens during the landing of Space Shuttle Atlantis (STS-125) at Edwards Air Force Base in California.

STS-125 Entry flight controllers on console with Flight Director Norman Knight

NASA Image and Video Library

2009-05-24

JSC2009-E-121512 (24 May 2009) --- Flight controllers in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center watch the big screens during the landing of Space Shuttle Atlantis (STS-125) at Edwards Air Force Base in California.

STS-125 Entry flight controllers on console with Flight Director Norman Knight

NASA Image and Video Library

2009-05-24

JSC2009-E-121509 (24 May 2009) --- Flight controllers in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center watch the big screens during the landing of Space Shuttle Atlantis (STS-125) at Edwards Air Force Base in California.

75 FR 80886 - Ninth Meeting-RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220: Automatic Flight Guidance and Control meeting. SUMMARY: The FAA is... for a Special Committee 220: Automatic Flight Guidance and Control meeting. The agenda will include...

Extraction of stability and control derivatives from orbiter flight data

NASA Technical Reports Server (NTRS)

Iliff, Kenneth W.; Shafer, Mary F.

1993-01-01

The Space Shuttle Orbiter has provided unique and important information on aircraft flight dynamics. This information has provided the opportunity to assess the flight-derived stability and control derivatives for maneuvering flight in the hypersonic regime. In the case of the Space Shuttle Orbiter, these derivatives are required to determine if certain configuration placards (limitations on the flight envelope) can be modified. These placards were determined on the basis of preflight predictions and the associated uncertainties. As flight-determined derivatives are obtained, the placards are reassessed, and some of them are removed or modified. Extraction of the stability and control derivatives was justified by operational considerations and not by research considerations. Using flight results to update the predicted database of the orbiter is one of the most completely documented processes for a flight vehicle. This process followed from the requirement for analysis of flight data for control system updates and for expansion of the operational flight envelope. These results show significant changes in many important stability and control derivatives from the preflight database. This paper presents some of the stability and control derivative results obtained from Space Shuttle flights. Some of the limitations of this information are also examined.

Robust integrated flight/propulsion control design for a STOVL aircraft using H-infinity control design techniques

NASA Technical Reports Server (NTRS)

Garg, Sanjay

1993-01-01

Results are presented from an application of H-infinity control design methodology to a centralized integrated flight/propulsion control (IFPC) system design for a supersonic STOVL fighter aircraft in transition flight. The emphasis is on formulating the H-infinity optimal control synthesis problem such that the critical requirements for the flight and propulsion systems are adequately reflected within the linear, centralized control problem formulation and the resulting controller provides robustness to modeling uncertainties and model parameter variations with flight condition. Detailed evaluation results are presented for a reduced order controller obtained from the improved H-infinity control design showing that the control design meets the specified nominal performance objective as well as provides stability robustness for variations in plant system dynamics with changes in aircraft trim speed within the transition flight envelope.

Pigeons (C. livia) Follow Their Head during Turning Flight: Head Stabilization Underlies the Visual Control of Flight.

PubMed

Ros, Ivo G; Biewener, Andrew A

2017-01-01

Similar flight control principles operate across insect and vertebrate fliers. These principles indicate that robust solutions have evolved to meet complex behavioral challenges. Following from studies of visual and cervical feedback control of flight in insects, we investigate the role of head stabilization in providing feedback cues for controlling turning flight in pigeons. Based on previous observations that the eyes of pigeons remain at relatively fixed orientations within the head during flight, we test potential sensory control inputs derived from head and body movements during 90° aerial turns. We observe that periods of angular head stabilization alternate with rapid head repositioning movements (head saccades), and confirm that control of head motion is decoupled from aerodynamic and inertial forces acting on the bird's continuously rotating body during turning flapping flight. Visual cues inferred from head saccades correlate with changes in flight trajectory; whereas the magnitude of neck bending predicts angular changes in body position. The control of head motion to stabilize a pigeon's gaze may therefore facilitate extraction of important motion cues, in addition to offering mechanisms for controlling body and wing movements. Strong similarities between the sensory flight control of birds and insects may also inspire novel designs of robust controllers for human-engineered autonomous aerial vehicles.

Pigeons (C. livia) Follow Their Head during Turning Flight: Head Stabilization Underlies the Visual Control of Flight

PubMed Central

Ros, Ivo G.; Biewener, Andrew A.

2017-01-01

Similar flight control principles operate across insect and vertebrate fliers. These principles indicate that robust solutions have evolved to meet complex behavioral challenges. Following from studies of visual and cervical feedback control of flight in insects, we investigate the role of head stabilization in providing feedback cues for controlling turning flight in pigeons. Based on previous observations that the eyes of pigeons remain at relatively fixed orientations within the head during flight, we test potential sensory control inputs derived from head and body movements during 90° aerial turns. We observe that periods of angular head stabilization alternate with rapid head repositioning movements (head saccades), and confirm that control of head motion is decoupled from aerodynamic and inertial forces acting on the bird's continuously rotating body during turning flapping flight. Visual cues inferred from head saccades correlate with changes in flight trajectory; whereas the magnitude of neck bending predicts angular changes in body position. The control of head motion to stabilize a pigeon's gaze may therefore facilitate extraction of important motion cues, in addition to offering mechanisms for controlling body and wing movements. Strong similarities between the sensory flight control of birds and insects may also inspire novel designs of robust controllers for human-engineered autonomous aerial vehicles. PMID:29249929

Flight Test Results on the Stability and Control of the F-15B Quiet Spike Aircraft

NASA Technical Reports Server (NTRS)

Moua, Cheng; McWherter, Shaun H.; Cox, Timothy H.; Gera, Joseph

2007-01-01

The Quiet Spike (QS) flight research program was an aerodynamic and structural proof-of-concept of a telescoping sonic-boom suppressing nose boom on an F-15 B aircraft. The program goal was to collect flight data for model validation up to 1.8 Mach. The primary test philosophy was maintaining safety of flight. In the area of stability and controls the primary concerns were to assess the potential destabilizing effect of the spike on the stability, controllability, and handling qualities of the aircraft and to ensure adequate stability margins across the entire QS flight envelop. This paper reports on the stability and control methods used for flight envelope clearance and flight test results of the F-15B Quiet Spike. Also discussed are the flight test approach, the criteria to proceed to the next flight condition, brief pilot commentary on typical piloting tasks, approach and landing, and refueling task, and air data sensitivity to the flight control system.

Production Support Flight Control Computers: Research Capability for F/A-18 Aircraft at Dryden Flight Research Center

NASA Technical Reports Server (NTRS)

Carter, John F.

1997-01-01

NASA Dryden Flight Research Center (DFRC) is working with the United States Navy to complete ground testing and initiate flight testing of a modified set of F/A-18 flight control computers. The Production Support Flight Control Computers (PSFCC) can give any fleet F/A-18 airplane an in-flight, pilot-selectable research control law capability. NASA DFRC can efficiently flight test the PSFCC for the following four reasons: (1) Six F/A-18 chase aircraft are available which could be used with the PSFCC; (2) An F/A-18 processor-in-the-loop simulation exists for validation testing; (3) The expertise has been developed in programming the research processor in the PSFCC; and (4) A well-defined process has been established for clearing flight control research projects for flight. This report presents a functional description of the PSFCC. Descriptions of the NASA DFRC facilities, PSFCC verification and validation process, and planned PSFCC projects are also provided.

Initial flight qualification and operational maintenance of X-29A flight software

NASA Technical Reports Server (NTRS)

Earls, Michael R.; Sitz, Joel R.

1989-01-01

A discussion is presented of some significant aspects of the initial flight qualification and operational maintenance of the flight control system softward for the X-29A technology demonstrator. Flight qualification and maintenance of complex, embedded flight control system software poses unique problems. The X-29A technology demonstrator aircraft has a digital flight control system which incorporates functions generally considered too complex for analog systems. Organizational responsibilities, software assurance issues, tools, and facilities are discussed.

STS-106 Orbit 2 Flight Team

NASA Image and Video Library

2000-09-14

JSC2000-06244 (September 2000)--- Flight director Jeff Hanley, front center, and the fifty-odd flight controllers making up the ISS Orbit 2 Team pose for their group portrait in the ISS Flight Control Room of Houston's Mission Control Center.

New Developments in NASA's Rodent Research Hardware for Conducting Long Duration Biomedical and Basic Research in Space

NASA Technical Reports Server (NTRS)

Shirazi, Yasaman; Choi, S.; Harris, C.; Gong, C.; Fisher, R. J.; Beegle, J. E.; Stube, K. C.; Martin, K. J.; Nevitt, R. G.; Globus, R. K.

2017-01-01

Animal models, particularly rodents, are the foundation of pre-clinical research to understand human diseases and evaluate new therapeutics, and play a key role in advancing biomedical discoveries both on Earth and in space. The National Research Councils Decadal survey emphasized the importance of expanding NASA's life sciences research to perform long duration, rodent experiments on the International Space Station (ISS) to study effects of the space environment on the musculoskeletal and neurological systems of mice as model organisms of human health and disease, particularly in areas of muscle atrophy, bone loss, and fracture healing. To accomplish this objective, flight hardware, operations, and science capabilities were developed at NASA Ames Research Center (ARC) to enhance science return for both commercial (CASIS) and government-sponsored rodent research. The Rodent Research Project at NASA ARC has pioneered a new research capability on the International Space Station and has progressed toward translating research to the ISS utilizing commercial rockets, collaborating with academia and science industry, while training crewmembers to assist in performing research on orbit. The Rodent Research Habitat provides a living environment for animals on ISS according to standard animal welfare requirements, and daily health checks can be performed using the habitats camera system. Results from these studies contribute to the science community via both the primary investigation and banked samples that are shared in publicly available data repository such as GeneLab. Following each flight, through the Biospecimen Sharing Program (BSP), numerous tissues and thousands of samples will be harvested, and distributed from the Space Life and Physical Sciences (SLPS) to Principal Investigators (PIs) through the Ames Life Science Data Archive (ALSDA). Every completed mission sets a foundation to build and design greater complexity into future research and answer questions about common human diseases. Together, the hardware improvements (enrichment, telemetry sensors, cameras), new capabilities (live animal return), and experience that the Rodent Research team has gained working with principal investigator teams and ISS crew to conduct complex experiments on orbit are expanding capabilities for long duration rodent research on the ISS to achieve both basic science and biomedical research objectives.

Remotely Piloted Vehicles for Experimental Flight Control Testing

NASA Technical Reports Server (NTRS)

Motter, Mark A.; High, James W.

2009-01-01

A successful flight test and training campaign of the NASA Flying Controls Testbed was conducted at Naval Outlying Field, Webster Field, MD during 2008. Both the prop and jet-powered versions of the subscale, remotely piloted testbeds were used to test representative experimental flight controllers. These testbeds were developed by the Subsonic Fixed Wing Project s emphasis on new flight test techniques. The Subsonic Fixed Wing Project is under the Fundamental Aeronautics Program of NASA's Aeronautics Research Mission Directorate (ARMD). The purpose of these testbeds is to quickly and inexpensively evaluate advanced concepts and experimental flight controls, with applications to adaptive control, system identification, novel control effectors, correlation of subscale flight tests with wind tunnel results, and autonomous operations. Flight tests and operator training were conducted during four separate series of tests during April, May, June and August 2008. Experimental controllers were engaged and disengaged during fully autonomous flight in the designated test area. Flaps and landing gear were deployed by commands from the ground control station as unanticipated disturbances. The flight tests were performed NASA personnel with support from the Maritime Unmanned Development and Operations (MUDO) team of the Naval Air Warfare Center, Aircraft Division

Design Challenges Encountered in a Propulsion-Controlled Aircraft Flight Test Program

NASA Technical Reports Server (NTRS)

Maine, Trindel; Burken, John; Burcham, Frank; Schaefer, Peter

1994-01-01

The NASA Dryden Flight Research Center conducted flight tests of a propulsion-controlled aircraft system on an F-15 airplane. This system was designed to explore the feasibility of providing safe emergency landing capability using only the engines to provide flight control in the event of a catastrophic loss of conventional flight controls. Control laws were designed to control the flightpath and bank angle using only commands to the throttles. Although the program was highly successful, this paper highlights some of the challenges associated with using engine thrust as a control effector. These challenges include slow engine response time, poorly modeled nonlinear engine dynamics, unmodeled inlet-airframe interactions, and difficulties with ground effect and gust rejection. Flight and simulation data illustrate these difficulties.

Document handover of ISS Flight Control room to new Flight Control Room in old MCC

NASA Image and Video Library

2006-10-06

JSC2006-E-43860 (6 Oct. 2006)--- International Space Station flight controllers have this area as their new home with increased technical capabilities, more workspace and a long, distinguished history. The newly updated facility is just down the hall from its predecessor at NASA's Johnson Space Center, Houston. Known as Flight Control Room 1, it was first used to control a space flight 38 years ago, the mission of Apollo 7 launched Oct. 11, 1968. It was one of two control rooms for NASA's manned missions. The room it replaces in its new ISS role, designated the Blue Flight Control Room, had been in operation since the first station component was launched in 1998.

A fault-tolerant control architecture for unmanned aerial vehicles

NASA Astrophysics Data System (ADS)

Drozeski, Graham R.

Research has presented several approaches to achieve varying degrees of fault-tolerance in unmanned aircraft. Approaches in reconfigurable flight control are generally divided into two categories: those which incorporate multiple non-adaptive controllers and switch between them based on the output of a fault detection and identification element, and those that employ a single adaptive controller capable of compensating for a variety of fault modes. Regardless of the approach for reconfigurable flight control, certain fault modes dictate system restructuring in order to prevent a catastrophic failure. System restructuring enables active control of actuation not employed by the nominal system to recover controllability of the aircraft. After system restructuring, continued operation requires the generation of flight paths that adhere to an altered flight envelope. The control architecture developed in this research employs a multi-tiered hierarchy to allow unmanned aircraft to generate and track safe flight paths despite the occurrence of potentially catastrophic faults. The hierarchical architecture increases the level of autonomy of the system by integrating five functionalities with the baseline system: fault detection and identification, active system restructuring, reconfigurable flight control; reconfigurable path planning, and mission adaptation. Fault detection and identification algorithms continually monitor aircraft performance and issue fault declarations. When the severity of a fault exceeds the capability of the baseline flight controller, active system restructuring expands the controllability of the aircraft using unconventional control strategies not exploited by the baseline controller. Each of the reconfigurable flight controllers and the baseline controller employ a proven adaptive neural network control strategy. A reconfigurable path planner employs an adaptive model of the vehicle to re-shape the desired flight path. Generation of the revised flight path is posed as a linear program constrained by the response of the degraded system. Finally, a mission adaptation component estimates limitations on the closed-loop performance of the aircraft and adjusts the aircraft mission accordingly. A combination of simulation and flight test results using two unmanned helicopters validates the utility of the hierarchical architecture.

Assessment of the State of the Art of Flight Control Technologies as Applicable to Adverse Conditions

NASA Technical Reports Server (NTRS)

Reveley, Mary s.; Briggs, Jeffrey L.; Leone, Karen M.; Kurtoglu, Tolga; Withrow, Colleen A.

2010-01-01

Literature from academia, industry, and other Government agencies was surveyed to assess the state of the art in current Integrated Resilient Aircraft Control (IRAC) aircraft technologies. Over 100 papers from 25 conferences from the time period 2004 to 2009 were reviewed. An assessment of the general state of the art in adaptive flight control is summarized first, followed by an assessment of the state of the art as applicable to 13 identified adverse conditions. Specific areas addressed in the general assessment include flight control when compensating for damage or reduced performance, retrofit software upgrades to flight controllers, flight control through engine response, and finally test and validation of new adaptive controllers. The state-of-the-art assessment applicable to the adverse conditions include technologies not specifically related to flight control, but may serve as inputs to a future flight control algorithm. This study illustrates existing gaps and opportunities for additional research by the NASA IRAC Project

Integrated Resilient Aircraft Control Project Full Scale Flight Validation

NASA Technical Reports Server (NTRS)

Bosworth, John T.

2009-01-01

Objective: Provide validation of adaptive control law concepts through full scale flight evaluation. Technical Approach: a) Engage failure mode - destabilizing or frozen surface. b) Perform formation flight and air-to-air tracking tasks. Evaluate adaptive algorithm: a) Stability metrics. b) Model following metrics. Full scale flight testing provides an ability to validate different adaptive flight control approaches. Full scale flight testing adds credence to NASA's research efforts. A sustained research effort is required to remove the road blocks and provide adaptive control as a viable design solution for increased aircraft resilience.

Potential commercial use of the International Space Station by the biotechnology/pharmaceutical/biomedical sector

NASA Astrophysics Data System (ADS)

Morgenthaler, George W.; Stodieck, Louis

1999-01-01

The International Space Station (ISS) is the linch-pin of NASA's future space plans. It emphasizes scientific research by providing a world-class scientific laboratory in which to perform long-term basic science experiments in the space environment of microgravity, radiation, vacuum, vantage-point, etc. It will serve as a test-bed for determining human system response to long-term space flight and for developing the life support equipment necessary for NASA's Human Exploration and Development of Space (HEDS) enterprise. The ISS will also provide facilities (up to 30% of the U.S. module) for testing material, agricultural, cellular, human, aquatic, and plant/animal systems to reveal phenomena heretofore shrouded by the veil of 1-g. These insights will improve life on Earth and will provide a commercial basis for new products and services. In fact, some products, e.g., rare metal-alloys, semiconductor chips, or protein crystals that cannot now be produced on Earth may be found to be sufficiently valuable to be manufactured on-orbit. Biotechnology, pharmaceutical and biomedical experiments have been regularly flown on 10-16 day Space Shuttle flights and on three-month Mir flights for basic science knowledge and for life support system and commercial product development. Since 1985, NASA has created several Commercial Space Centers (CSCs) for the express purpose of bringing university, government and industrial researchers together to utilize space flight and space technology to develop new industrial products and processes. BioServe Space Technologies at the University of Colorado at Boulder and Kansas State University, Manhattan, Kansas, is such a NASA sponsored CSC that has worked with over 65 companies and institutions in the Biotech Sector in the past 11 years and has successfully discovered and transferred new product and process information to its industry partners. While tests in the space environment have been limited to about two weeks on Shuttle or a few months on Mir, tests on ISS can be performed over many months, or even years. More importantly, a test can be regularly scheduled so that the effects of microgravity and other space environment parameters can be thoroughly researched and quantified. This paper attempts to envision the potential benefits of this soon-to-be-available orbital laboratory and the broad commercial utilization of ISS that will likely occur.

Propulsion system/flight control integration for supersonic aircraft

NASA Technical Reports Server (NTRS)

Reukauf, P. J.; Burcham, F. W., Jr.

1976-01-01

Digital integrated control systems are studied. Such systems allow minimization of undesirable interactions while maximizing performance at all flight conditions. One such program is the YF-12 cooperative control program. The existing analog air data computer, autothrottle, autopilot, and inlet control systems are converted to digital systems by using a general purpose airborne computer and interface unit. Existing control laws are programed and tested in flight. Integrated control laws, derived using accurate mathematical models of the airplane and propulsion system in conjunction with modern control techniques, are tested in flight. Analysis indicates that an integrated autothrottle autopilot gives good flight path control and that observers are used to replace failed sensors.

High Stability Engine Control (HISTEC) Flight Test Results

NASA Technical Reports Server (NTRS)

Southwick, Robert D.; Gallops, George W.; Kerr, Laura J.; Kielb, Robert P.; Welsh, Mark G.; DeLaat, John C.; Orme, John S.

1998-01-01

The High Stability Engine Control (HISTEC) Program, managed and funded by the NASA Lewis Research Center, is a cooperative effort between NASA and Pratt & Whitney (P&W). The program objective is to develop and flight demonstrate an advanced high stability integrated engine control system that uses real-time, measurement-based estimation of inlet pressure distortion to enhance engine stability. Flight testing was performed using the NASA Advanced Controls Technologies for Integrated Vehicles (ACTIVE) F-15 aircraft at the NASA Dryden Flight Research Center. The flight test configuration, details of the research objectives, and the flight test matrix to achieve those objectives are presented. Flight test results are discussed that show the design approach can accurately estimate distortion and perform real-time control actions for engine accommodation.

Implementation of an Adaptive Controller System from Concept to Flight Test

NASA Technical Reports Server (NTRS)

Larson, Richard R.; Burken, John J.; Butler, Bradley S.; Yokum, Steve

2009-01-01

The National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California) is conducting ongoing flight research using adaptive controller algorithms. A highly modified McDonnell-Douglas NF-15B airplane called the F-15 Intelligent Flight Control System (IFCS) is used to test and develop these algorithms. Modifications to this airplane include adding canards and changing the flight control systems to interface a single-string research controller processor for neural network algorithms. Research goals include demonstration of revolutionary control approaches that can efficiently optimize aircraft performance in both normal and failure conditions and advancement of neural-network-based flight control technology for new aerospace system designs. This report presents an overview of the processes utilized to develop adaptive controller algorithms during a flight-test program, including a description of initial adaptive controller concepts and a discussion of modeling formulation and performance testing. Design finalization led to integration with the system interfaces, verification of the software, validation of the hardware to the requirements, design of failure detection, development of safety limiters to minimize the effect of erroneous neural network commands, and creation of flight test control room displays to maximize human situational awareness; these are also discussed.

In-Flight Suppression of a Destabilized F/A-18 Structural Mode Using the Space Launch System Adaptive Augmenting Control System

NASA Technical Reports Server (NTRS)

Wall, John H.; VanZwieten, Tannen S.; Gilligan, Eric T.; Miller, Christopher J.; Hanson, Curtis E.; Orr, Jeb S.

2015-01-01

NASA's Space Launch System (SLS) Flight Control System (FCS) includes an Adaptive Augmenting Control (AAC) component which employs a multiplicative gain update law to enhance the performance and robustness of the baseline control system for extreme off nominal scenarios. The SLS FCS algorithm including AAC has been flight tested utilizing a specially outfitted F/A-18 fighter jet in which the pitch axis control of the aircraft was performed by a Non-linear Dynamic Inversion (NDI) controller, SLS reference models, and the SLS flight software prototype. This paper describes test cases from the research flight campaign in which the fundamental F/A-18 airframe structural mode was identified using frequency-domain reconstruction of flight data, amplified to result in closed loop instability, and suppressed in-flight by the SLS adaptive control system.

75 FR 59326 - Eighth Meeting-RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... Committee 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220: Automatic Flight Guidance and Control meeting. SUMMARY: The... Flight Guidance and Control. DATES: The meeting will be held October 12-14, 2010. October 12th and 13th...

76 FR 50809 - Eleventh Meeting: RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... Committee 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Correction of Notice of RTCA Special Committee 220 meeting: Automatic Flight Guidance and Control...: Automatic Flight Guidance and Control DATES: The meeting will be held September 13-15, 2011, from 9 a.m. to...

STS-132/ULF-4 Flight Control Team in FCR-1

NASA Image and Video Library

2010-05-20

JSC2010-E-085365 (20 May 2010) --- The members of the STS-132/ULF-4 ISS Orbit 2 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Emily Nelson holds the Expedition 23 mission logo.

STS-124/1J ISS Orbit 3 flight control team portrait

NASA Image and Video Library

2008-06-09

JSC2008-E-045777 (9 June 2008) --- The members of the STS-124/1J ISS Orbit 3 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Emily Nelson stands in the center foreground.

STS-132/ULF-4 Flight Control Team in FCR-1

NASA Image and Video Library

2010-05-19

JSC2010-E-086277 (19 May 2010) --- The members of the STS-132/ULF-4 ISS Orbit 1 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Holly Ridings holds the STS-132 mission logo.

STS-132 Flight Control Team in WFCR - Orbit 1

NASA Image and Video Library

2010-05-22

JSC2010-E-086698 (22 May 2010) --- The members of the STS-132 Orbit 1 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Mike Sarafin (center) is visible on the front row.

STS-132 Flight Control Team in WFCR - Orbit 2

NASA Image and Video Library

2010-05-20

JSC2010-E-086451 (20 May 2010) --- The members of the STS-132 Orbit 2 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Chris Edelen (second left) is visible on the front row.

STS-132/ULF-4 Flight Control Team in FCR-1

NASA Image and Video Library

2010-05-20

JSC2010-E-086504 (20 May 2010) --- The members of the STS-132/ULF-4 ISS Orbit 3 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Scott Stover holds the Expedition 23 mission logo.

Some psychophysiological and behavioral aspects of adaptation to simulated autonomous Mission to Mars

NASA Astrophysics Data System (ADS)

Gushin, V.; Shved, D.; Vinokhodova, A.; Vasylieva, G.; Nitchiporuk, I.; Ehmann, B.; Balazs, L.

2012-01-01

“Mars-105” experiment was executed in March-July 2009 in Moscow, at the Institute for Bio-Medical Problems (IBMP) with participation of European Space Agency (ESA) to simulate some specific conditions of future piloted Mars mission. In the last 35 days of isolation, in order to simulate autonomous flight conditions, some serious restrictions were established for the crew resupply and communication with Mission Control (MC). The objective of the study was to investigate psychophysiological and behavioral aspects (communication) of adaptation during this period of “high autonomy”. We used computerized analysis of the crew written daily reports to calculate the frequencies of utilization of certain semantic units, expressing different psychological functions. To estimate the level of psycho-physiological stress, we measured the concentration of urinal cortisol once in two weeks. To investigate psycho-emotional state, we used the questionnaire SAN, estimating Mood, Activity and Health once in two weeks.During the simulation of autonomous flight, we found out the different tendencies of communicative behavior. One group of subjects demonstrated the tendency to “activation and self-government” under “high autonomy” conditions. The other subjects continued to use communicative strategy that we called “closing the communication channel”. “Active” communication strategy was accompanied by increasing in subjective scores of mood and activity. The subjects, whose communication strategy was attributed as “closing”, demonstrated the considerably lower subjective scores of mood and activity. Period of high autonomy causes specific changes in communication strategies of the isolated crew.

Graduate program in biomedical communication.

PubMed

Ryan, S M

1969-10-01

The need for harnessing the achievements of communication technology to the burgeoning mass of biomedical information is critical. Recognizing this problem and aware of the short supply of professionals with the skills necessary for the job, a group of leaders from the fields of medicine and communications formed a consortium in 1967 and have developed a twelve month graduate program in biomedical communication. Designed to ground the advanced student in the development and administration of biomedical communication programs, the curriculum focuses on the principles and practice of communication and the development of communications media. Courses are given in the control and communication of information; the printed and spoken word; visual media of photographic arts, television, and motion pictures; computer science; and administration and systems analysis.

Graduate Program in Biomedical Communication *

PubMed Central

Ryan, Susan M.

1969-01-01

The need for harnessing the achievements of communication technology to the burgeoning mass of biomedical information is critical. Recognizing this problem and aware of the short supply of professionals with the skills necessary for the job, a group of leaders from the fields of medicine and communications formed a consortium in 1967 and have developed a twelve month graduate program in biomedical communication. Designed to ground the advanced student in the development and administration of biomedical communication programs, the curriculum focuses on the principles and practice of communication and the development of communications media. Courses are given in the control and communication of information; the printed and spoken word; visual media of photographic arts, television, and motion pictures; computer science; and administration and systems analysis. PMID:5823505

Space Shuttle stability and control test plan

NASA Technical Reports Server (NTRS)

Cooke, D. R.

1982-01-01

The development of a completely automatic flight test program to test different aspects of the Shuttle flight capability during reentries is described. Data from each flight to date has been employed to devise a sequence of maneuvers which will be keyboard-punched into the Orbiter control system by the astronauts during entry phases of flight. Details of the interaction and cooperation of the Orbiter elevons and bodyflap to provide the vehicle with latitudinal and longitudinal directional control and trim are outlined. Uncertainties predicted for the control of the Orbiter during wind tunnel testing prior to actual flights have been adjusted to actual flight data, leading to the identification of actual flight regimes which need further investigation. Maneuvers scheduled for flights 5-9 are reviewed.

HIDEC F-15 adaptive engine control system flight test results

NASA Technical Reports Server (NTRS)

Smolka, James W.

1987-01-01

NASA-Ames' Highly Integrated Digital Electronic Control (HIDEC) flight test program aims to develop fully integrated airframe, propulsion, and flight control systems. The HIDEC F-15 adaptive engine control system flight test program has demonstrated that significant performance improvements are obtainable through the retention of stall-free engine operation throughout the aircraft flight and maneuver envelopes. The greatest thrust increase was projected for the medium-to-high altitude flight regime at subsonic speed which is of such importance to air combat. Adaptive engine control systems such as the HIDEC F-15's can be used to upgrade the performance of existing aircraft without resort to expensive reengining programs.

Remote radio control of insect flight.

PubMed

Sato, Hirotaka; Berry, Christopher W; Peeri, Yoav; Baghoomian, Emen; Casey, Brendan E; Lavella, Gabriel; Vandenbrooks, John M; Harrison, Jon F; Maharbiz, Michel M

2009-01-01

We demonstrated the remote control of insects in free flight via an implantable radio-equipped miniature neural stimulating system. The pronotum mounted system consisted of neural stimulators, muscular stimulators, a radio transceiver-equipped microcontroller and a microbattery. Flight initiation, cessation and elevation control were accomplished through neural stimulus of the brain which elicited, suppressed or modulated wing oscillation. Turns were triggered through the direct muscular stimulus of either of the basalar muscles. We characterized the response times, success rates, and free-flight trajectories elicited by our neural control systems in remotely controlled beetles. We believe this type of technology will open the door to in-flight perturbation and recording of insect flight responses.

Applications of Payload Directed Flight

NASA Technical Reports Server (NTRS)

Ippolito, Corey; Fladeland, Matthew M.; Yeh, Yoo Hsiu

2009-01-01

Next generation aviation flight control concepts require autonomous and intelligent control system architectures that close control loops directly around payload sensors in manner more integrated and cohesive that in traditional autopilot designs. Research into payload directed flight control at NASA Ames Research Center is investigating new and novel architectures that can satisfy the requirements for next generation control and automation concepts for aviation. Tighter integration between sensor and machine requires definition of specific sensor-directed control modes to tie the sensor data directly into a vehicle control structures throughout the entire control architecture, from low-level stability- and control loops, to higher level mission planning and scheduling reasoning systems. Payload directed flight systems can thus provide guidance, navigation, and control for vehicle platforms hosting a suite of onboard payload sensors. This paper outlines related research into the field of payload directed flight; and outlines requirements and operating concepts for payload directed flight systems based on identified needs from the scientific literature.'

Specificity of Good Manufacturing Practice (GMP) for Biomedical Cell Products.

PubMed

Tulina, M A; Pyatigorskaya, N V

2018-03-01

The article describes special aspects of Good Manufacturing Practice (GMP) for biomedical cell products (BMCP) that imply high standards of aseptics throughout the entire productio process, strict requirements to donors and to the procedure of biomaterial isolation, guaranty of tracing BMCP products, defining processing procedures which allow to identify BMCP as minimally manipulated; continuous quality control and automation of the control process at all stages of manufacturing, which will ensure product release simultaneously with completion of technological operations.

The NASA Lewis integrated propulsion and flight control simulator

NASA Technical Reports Server (NTRS)

Bright, Michelle M.; Simon, Donald L.

1991-01-01

A new flight simulation facility was developed at NASA-Lewis. The purpose of this flight simulator is to allow integrated propulsion control and flight control algorithm development and evaluation in real time. As a preliminary check of the simulator facility capabilities and correct integration of its components, the control design and physics models for a short take-off and vertical landing fighter aircraft model were shown, with their associated system integration and architecture, pilot vehicle interfaces, and display symbology. The initial testing and evaluation results show that this fixed based flight simulator can provide real time feedback and display of both airframe and propulsion variables for validation of integrated flight and propulsion control systems. Additionally, through the use of this flight simulator, various control design methodologies and cockpit mechanizations can be tested and evaluated in a real time environment.

F-15 HiDEC in flight over Mojave desert

NASA Technical Reports Server (NTRS)

1990-01-01

NASA's F-15 HIDEC (Highly Integrated Digital Electronic Control) research aircraft cruises over California's Mojave Desert at sunset on a flight out of the Dryden Flight Research Center, Edwards, California. The aircraft was used to carry out research on engine and flight control systems and most recently demonstrated the use of computer-assisted engine controls as a means of landing an aircraft safely with only engine power if its normal control surfaces such as elevators, rudders or ailerons are disabled. The aircraft also tested and evaluated a computerized self-repair flight control system for the Air Force that detects damaged or failed flight control surfaces, and then reconfigures undamaged flight surfaces so the mission can continue or the aircraft is landed safely. Nearly all research being carried out in the HIDEC program is applicable to future civilian and military aircraft.

14 CFR 121.597 - Flight release authority: Supplemental operations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... flight following system without specific authority from the person authorized by the operator to exercise operational control over the flight. (b) No person may start a flight unless the pilot in command or the person authorized by the operator to exercise operational control over the flight has executed a flight...

STS-134 Orbit 2 flight controllers on consoles

NASA Image and Video Library

2011-05-17

JSC2011-E-045475 (17 May 2011) --- Flight director Paul Dye monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-134 flight day two activities. Photo credit: NASA

STS-132/ULF4 Flight Controllers on Console - Orbit 2

NASA Image and Video Library

2010-05-17

JSC2010-E-084363 (17 May 2010) --- Flight director Chris Edelen monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132 flight day four activities.

Digital fabrication of multi-material biomedical objects.

PubMed

Cheung, H H; Choi, S H

2009-12-01

This paper describes a multi-material virtual prototyping (MMVP) system for modelling and digital fabrication of discrete and functionally graded multi-material objects for biomedical applications. The MMVP system consists of a DMMVP module, an FGMVP module and a virtual reality (VR) simulation module. The DMMVP module is used to model discrete multi-material (DMM) objects, while the FGMVP module is for functionally graded multi-material (FGM) objects. The VR simulation module integrates these two modules to perform digital fabrication of multi-material objects, which can be subsequently visualized and analysed in a virtual environment to optimize MMLM processes for fabrication of product prototypes. Using the MMVP system, two biomedical objects, including a DMM human spine and an FGM intervertebral disc spacer are modelled and digitally fabricated for visualization and analysis in a VR environment. These studies show that the MMVP system is a practical tool for modelling, visualization, and subsequent fabrication of biomedical objects of discrete and functionally graded multi-materials for biomedical applications. The system may be adapted to control MMLM machines with appropriate hardware for physical fabrication of biomedical objects.

Effects of an educational intervention on female biomedical scientists' research self-efficacy.

PubMed

Bakken, Lori L; Byars-Winston, Angela; Gundermann, Dawn M; Ward, Earlise C; Slattery, Angela; King, Andrea; Scott, Denise; Taylor, Robert E

2010-05-01

Women and people of color continue to be underrepresented among biomedical researchers to an alarming degree. Research interest and subsequent productivity have been shown to be affected by the research training environment through the mediating effects of research self-efficacy. This article presents the findings of a study to determine whether a short-term research training program coupled with an efficacy enhancing intervention for novice female biomedical scientists of diverse racial backgrounds would increase their research self-efficacy beliefs. Forty-three female biomedical scientists were randomized into a control or intervention group and 15 men participated as a control group. Research self-efficacy significantly increased for women who participated in the self-efficacy intervention workshop. Research self-efficacy within each group also significantly increased following the short-term research training program, but cross-group comparisons were not significant. These findings suggest that educational interventions that target sources of self-efficacy and provide domain-specific learning experiences are effective at increasing research self-efficacy for women and men. Further studies are needed to determine the longitudinal outcomes of this effort.

Effects of an Educational Intervention on Female Biomedical Scientists’ Research Self-Efficacy

PubMed Central

Bakken, Lori L.; Byars-Winston, Angela; Gundermann, Dawn M.; Ward, Earlise C.; Slattery, Angela; King, Andrea; Scott, Denise; Taylor, Robert E.

2009-01-01

Women and people of color continue to be underrepresented among biomedical researchers to an alarming degree. Research interest and subsequent productivity have been shown to be affected by the research training environment through the mediating effects of research self-efficacy. This article presents the findings of a study to determine whether a short-term research training program coupled with an efficacy enhancing intervention for novice female biomedical scientists of diverse racial backgrounds would increase their research self-efficacy beliefs. Forty-three female biomedical scientists were randomized into a control or intervention group and 15 men participated as a control group. Research self-efficacy significantly increased for women who participated in the self-efficacy intervention workshop. Research self-efficacy within each group also significantly increased following the short-term research training program, but cross-group comparisons were not significant. These findings suggest that educational interventions that target sources of self-efficacy and provide domain-specific learning experiences are effective at increasing research self-efficacy for women and men. Further studies are needed to determine the longitudinal outcomes of this effort. PMID:19774477

Highly integrated digital electronic control: Digital flight control, aircraft model identification, and adaptive engine control

NASA Technical Reports Server (NTRS)

Baer-Riedhart, Jennifer L.; Landy, Robert J.

1987-01-01

The highly integrated digital electronic control (HIDEC) program at NASA Ames Research Center, Dryden Flight Research Facility is a multiphase flight research program to quantify the benefits of promising integrated control systems. McDonnell Aircraft Company is the prime contractor, with United Technologies Pratt and Whitney Aircraft, and Lear Siegler Incorporated as major subcontractors. The NASA F-15A testbed aircraft was modified by the HIDEC program by installing a digital electronic flight control system (DEFCS) and replacing the standard F100 (Arab 3) engines with F100 engine model derivative (EMD) engines equipped with digital electronic engine controls (DEEC), and integrating the DEEC's and DEFCS. The modified aircraft provides the capability for testing many integrated control modes involving the flight controls, engine controls, and inlet controls. This paper focuses on the first two phases of the HIDEC program, which are the digital flight control system/aircraft model identification (DEFCS/AMI) phase and the adaptive engine control system (ADECS) phase.

Document handover of ISS Flight Control room to new Flight Control Room in old MCC

NASA Image and Video Library

2006-10-06

JSC2006-E-43863 (6 Oct. 2006)--- International Space Station flight controllers have this area as their new home with increased technical capabilities, more workspace and a long, distinguished history. The newly updated facility is just down the hall from its predecessor at NASA's Johnson Space Center, Houston. This view is toward the rear of the "new" room. Known as Flight Control Room 1, it was first used to control a space flight 38 years ago, the mission of Apollo 7 launched Oct. 11, 1968. It was one of two control rooms for NASA's manned missions. The room it replaces in its new ISS role, designated the Blue Flight Control Room, had been in operation since the first station component was launched in 1998.

Launch Vehicle Manual Steering with Adaptive Augmenting Control In-flight Evaluations of Adverse Interactions Using a Piloted Aircraft

NASA Technical Reports Server (NTRS)

Hanson, Curt; Miller, Chris; Wall, John H.; Vanzwieten, Tannen S.; Gilligan, Eric; Orr, Jeb S.

2015-01-01

An adaptive augmenting control algorithm for the Space Launch System has been developed at the Marshall Space Flight Center as part of the launch vehicles baseline flight control system. A prototype version of the SLS flight control software was hosted on a piloted aircraft at the Armstrong Flight Research Center to demonstrate the adaptive controller on a full-scale realistic application in a relevant flight environment. Concerns regarding adverse interactions between the adaptive controller and a proposed manual steering mode were investigated by giving the pilot trajectory deviation cues and pitch rate command authority. Two NASA research pilots flew a total of twenty five constant pitch-rate trajectories using a prototype manual steering mode with and without adaptive control.

Flight control optimization from design to assessment application on the Cessna Citation X business aircraft =

NASA Astrophysics Data System (ADS)

Boughari, Yamina

New methodologies have been developed to optimize the integration, testing and certification of flight control systems, an expensive process in the aerospace industry. This thesis investigates the stability of the Cessna Citation X aircraft without control, and then optimizes two different flight controllers from design to validation. The aircraft's model was obtained from the data provided by the Research Aircraft Flight Simulator (RAFS) of the Cessna Citation business aircraft. To increase the stability and control of aircraft systems, optimizations of two different flight control designs were performed: 1) the Linear Quadratic Regulation and the Proportional Integral controllers were optimized using the Differential Evolution algorithm and the level 1 handling qualities as the objective function. The results were validated for the linear and nonlinear aircraft models, and some of the clearance criteria were investigated; and 2) the Hinfinity control method was applied on the stability and control augmentation systems. To minimize the time required for flight control design and its validation, an optimization of the controllers design was performed using the Differential Evolution (DE), and the Genetic algorithms (GA). The DE algorithm proved to be more efficient than the GA. New tools for visualization of the linear validation process were also developed to reduce the time required for the flight controller assessment. Matlab software was used to validate the different optimization algorithms' results. Research platforms of the aircraft's linear and nonlinear models were developed, and compared with the results of flight tests performed on the Research Aircraft Flight Simulator. Some of the clearance criteria of the optimized H-infinity flight controller were evaluated, including its linear stability, eigenvalues, and handling qualities criteria. Nonlinear simulations of the maneuvers criteria were also investigated during this research to assess the Cessna Citation X's flight controller clearance, and therefore, for its anticipated certification.

Launch Vehicle Manual Steering with Adaptive Augmenting Control:In-Flight Evaluations of Adverse Interactions Using a Piloted Aircraft

NASA Technical Reports Server (NTRS)

Hanson, Curt; Miller, Chris; Wall, John H.; VanZwieten, Tannen S.; Gilligan, Eric T.; Orr, Jeb S.

2015-01-01

An Adaptive Augmenting Control (AAC) algorithm for the Space Launch System (SLS) has been developed at the Marshall Space Flight Center (MSFC) as part of the launch vehicle's baseline flight control system. A prototype version of the SLS flight control software was hosted on a piloted aircraft at the Armstrong Flight Research Center to demonstrate the adaptive controller on a full-scale realistic application in a relevant flight environment. Concerns regarding adverse interactions between the adaptive controller and a potential manual steering mode were also investigated by giving the pilot trajectory deviation cues and pitch rate command authority, which is the subject of this paper. Two NASA research pilots flew a total of 25 constant pitch rate trajectories using a prototype manual steering mode with and without adaptive control, evaluating six different nominal and off-nominal test case scenarios. Pilot comments and PIO ratings were given following each trajectory and correlated with aircraft state data and internal controller signals post-flight.

Research flight-control system development for the F-18 high alpha research vehicle

NASA Technical Reports Server (NTRS)

Pahle, Joseph W.; Powers, Bruce; Regenie, Victoria; Chacon, Vince; Degroote, Steve; Murnyak, Steven

1991-01-01

The F-18 high alpha research vehicle was recently modified by adding a thrust vectoring control system. A key element in the modification was the development of a research flight control system integrated with the basic F-18 flight control system. Discussed here are design requirements, system development, and research utility of the resulting configuration as an embedded system for flight research in the high angle of attack regime. Particular emphasis is given to control system modifications and control law features required for high angle of attack flight. Simulation results are used to illustrate some of the thrust vectoring control system capabilities and predicted maneuvering improvements.

Modeling pilot interaction with automated digital avionics systems: Guidance and control algorithms for contour and nap-of-the-Earth flight

NASA Technical Reports Server (NTRS)

Hess, Ronald A.

1990-01-01

A collection of technical papers are presented that cover modeling pilot interaction with automated digital avionics systems and guidance and control algorithms for contour and nap-of-the-earth flight. The titles of the papers presented are as follows: (1) Automation effects in a multiloop manual control system; (2) A qualitative model of human interaction with complex dynamic systems; (3) Generalized predictive control of dynamic systems; (4) An application of generalized predictive control to rotorcraft terrain-following flight; (5) Self-tuning generalized predictive control applied to terrain-following flight; and (6) Precise flight path control using a predictive algorithm.

Integrated Neural Flight and Propulsion Control System

NASA Technical Reports Server (NTRS)

Kaneshige, John; Gundy-Burlet, Karen; Norvig, Peter (Technical Monitor)

2001-01-01

This paper describes an integrated neural flight and propulsion control system. which uses a neural network based approach for applying alternate sources of control power in the presence of damage or failures. Under normal operating conditions, the system utilizes conventional flight control surfaces. Neural networks are used to provide consistent handling qualities across flight conditions and for different aircraft configurations. Under damage or failure conditions, the system may utilize unconventional flight control surface allocations, along with integrated propulsion control, when additional control power is necessary for achieving desired flight control performance. In this case, neural networks are used to adapt to changes in aircraft dynamics and control allocation schemes. Of significant importance here is the fact that this system can operate without emergency or backup flight control mode operations. An additional advantage is that this system can utilize, but does not require, fault detection and isolation information or explicit parameter identification. Piloted simulation studies were performed on a commercial transport aircraft simulator. Subjects included both NASA test pilots and commercial airline crews. Results demonstrate the potential for improving handing qualities and significantly increasing survivability rates under various simulated failure conditions.

HOME - An application of fault-tolerant techniques and system self-testing. [independent computer for helicopter flight control command monitoring

NASA Technical Reports Server (NTRS)

Holden, D. G.

1975-01-01

Hard Over Monitoring Equipment (HOME) has been designed to complement and enhance the flight safety of a flight research helicopter. HOME is an independent, highly reliable, and fail-safe special purpose computer that monitors the flight control commands issued by the flight control computer of the helicopter. In particular, HOME detects the issuance of a hazardous hard-over command for any of the four flight control axes and transfers the control of the helicopter to the flight safety pilot. The design of HOME incorporates certain reliability and fail-safe enhancement design features, such as triple modular redundancy, majority logic voting, fail-safe dual circuits, independent status monitors, in-flight self-test, and a built-in preflight exerciser. The HOME design and operation is described with special emphasis on the reliability and fail-safe aspects of the design.

76 FR 38742 - Eleventh Meeting: RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... Committee 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220 Meeting: Automatic Flight Guidance and Control. SUMMARY: The... Flight Guidance and Control DATES: The meeting will be held August 9-11, 2011, from 9 a.m. to 5 p.m...

75 FR 36471 - Seventh Meeting-RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... Committee 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220: Automatic Flight Guidance and Control meeting. SUMMARY: The... Flight Guidance and Control. DATES: The meeting will be held July 13-15, 2010. July 13th and 14th from 9...

STS-132 Flight Control Team in WFCR

NASA Image and Video Library

2010-05-25

JSC2010-E-087358 (25 May 2010) --- The members of the STS-132 Entry flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Tony Ceccacci holds the STS-132 mission logo. Photo credit: NASA or National Aeronautics and Space Administration

STS-132/ULF4 Flight Controllers on Console

NASA Image and Video Library

2010-05-18

JSC2010-E-081946 (18 May 2010) --- ISS flight director Emily Nelson monitors data at her console in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132/ULF-4 mission flight day five activities.

STS-132/ULF4 Flight Controllers on Console - Bldg. 30 south

NASA Image and Video Library

2010-05-20

JSC2010-E-086375 (20 May 2010) --- Flight director Mike Sarafin monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132 mission flight day seven activities.

STS-132/ULF4 Flight Controllers on Console - Bldg. 30 south

NASA Image and Video Library

2010-05-20

JSC2010-E-086399 (20 May 2010) --- Flight director Mike Sarafin monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132 mission flight day seven activities.

STS-132/ULF4 Flight Controllers on Console

NASA Image and Video Library

2010-05-18

JSC2010-E-081914 (18 May 2010) --- ISS flight director Holly Ridings reviews data at her console in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132/ULF-4 mission flight day five activities.

STS-106 Orbit 1 Flight Team with Phil Engelhauf in WFCR

NASA Image and Video Library

2000-09-15

JSC2000-06253 (15 Sept. 2000) --- Flight director Phil Engelauf, front center, and the other fifty-odd flight controllers making up the STS-106 Orbit 1 team, pose for their group portrait in the Flight Control Room of Houston's Mission Control Center.

URV Flight Test of an ADA Implemented Self-Repairing Flight Control System

DTIC Science & Technology

1992-08-01

USE ONLY(Leave blank) I2. REPORT DATE j3.REOTYPANDTSCVRD JAUG 1992 j FINAL 01/01/85--08/31/92 4. TITLE AND SUBTITLE URV FL GHT TEST OF AN ADA IMPLEMESNT...History of the XBQM-106 2 2.0 Self-Repairing Flight Control System 4 Introduction 2.1 Control System Reconfiguration 5 Strategy 2.2 Failure Detection...ji * Ill ’ha A GJ s.d I I I C S U L 3 2.0 Self-Repairing Flight Control System Introduction Self-Repairing Flight Control Systems (SRFCS) are an

A benchmark for fault tolerant flight control evaluation

NASA Astrophysics Data System (ADS)

Smaili, H.; Breeman, J.; Lombaerts, T.; Stroosma, O.

2013-12-01

A large transport aircraft simulation benchmark (REconfigurable COntrol for Vehicle Emergency Return - RECOVER) has been developed within the GARTEUR (Group for Aeronautical Research and Technology in Europe) Flight Mechanics Action Group 16 (FM-AG(16)) on Fault Tolerant Control (2004 2008) for the integrated evaluation of fault detection and identification (FDI) and reconfigurable flight control strategies. The benchmark includes a suitable set of assessment criteria and failure cases, based on reconstructed accident scenarios, to assess the potential of new adaptive control strategies to improve aircraft survivability. The application of reconstruction and modeling techniques, based on accident flight data, has resulted in high-fidelity nonlinear aircraft and fault models to evaluate new Fault Tolerant Flight Control (FTFC) concepts and their real-time performance to accommodate in-flight failures.

Flight Research Using F100 Engine P680063 in the NASA F-15 Airplane

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Conners, Timothy R.; Maxwell, Michael D.

1994-01-01

The value of flight research in developing and evaluating gas turbine engines is high. NASA Dryden Flight Research Center has been conducting flight research on propulsion systems for many years. The F100 engine has been tested in the NASA F-15 research airplane in the last three decades. One engine in particular, S/N P680063, has been used for the entire program and has been flown in many pioneering propulsion flight research activities. Included are detailed flight-to-ground facility tests; tests of the first production digital engine control system, the first active stall margin control system, the first performance-seeking control system; and the first use of computer-controlled engine thrust for emergency flight control. The flight research has been supplemented with altitude facility tests at key times. This paper presents a review of the tests of engine P680063, the F-15 airplanes in which it flew, and the role of the flight test in maturing propulsion technology.

Adaptive control of a millimeter-scale flapping-wing robot.

PubMed

Chirarattananon, Pakpong; Ma, Kevin Y; Wood, Robert J

2014-06-01

Challenges for the controlled flight of a robotic insect are due to the inherent instability of the system, complex fluid-structure interactions, and the general lack of a complete system model. In this paper, we propose theoretical models of the system based on the limited information available from previous work and a comprehensive flight controller. The modular flight controller is derived from Lyapunov function candidates with proven stability over a large region of attraction. Moreover, it comprises adaptive components that are capable of coping with uncertainties in the system that arise from manufacturing imperfections. We have demonstrated that the proposed methods enable the robot to achieve sustained hovering flights with relatively small errors compared to a non-adaptive approach. Simple lateral maneuvers and vertical takeoff and landing flights are also shown to illustrate the fidelity of the flight controller. The analysis suggests that the adaptive scheme is crucial in order to achieve millimeter-scale precision in flight control as observed in natural insect flight.

Piloted evaluation of an integrated propulsion and flight control simulator

NASA Technical Reports Server (NTRS)

Bright, Michelle M.; Simon, Donald L.

1992-01-01

This paper describes a piloted evaluation of the integrated flight and propulsion control simulator at NASA Lewis Research Center. The purpose of this evaluation is to demonstrate the suitability and effectiveness of this fixed based simulator for advanced integrated propulsion and airframe control design. The evaluation will cover control effector gains and deadbands, control effectiveness and control authority, and heads up display functionality. For this evaluation the flight simulator is configured for transition flight using an advanced Short Take-Off and vertical Landing fighter aircraft model, a simplified high-bypass turbofan engine model, fighter cockpit, displays, and pilot effectors. The paper describes the piloted tasks used for rating displays and control effector gains. Pilot comments and simulation results confirm that the display symbology and control gains are very adequate for the transition flight task. Additionally, it is demonstrated that this small-scale, fixed base flight simulator facility can adequately perform a real time, piloted control evaluation.

Integrated Flight-propulsion Control Concepts for Supersonic Transport Airplanes

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Gilyard, Glenn B.; Gelhausen, Paul A.

1990-01-01

Integration of propulsion and flight control systems will provide significant performance improvements for supersonic transport airplanes. Increased engine thrust and reduced fuel consumption can be obtained by controlling engine stall margin as a function of flight and engine operating conditions. Improved inlet pressure recovery and decreased inlet drag can result from inlet control system integration. Using propulsion system forces and moments to augment the flight control system and airplane stability can reduce the flight control surface and tail size, weight, and drag. Special control modes may also be desirable for minimizing community noise and for emergency procedures. The overall impact of integrated controls on the takeoff gross weight for a generic high speed civil transport is presented.

Flight Characteristics of a 1/4-Scale Model of the XFV-1 Airplane (TED No. NACA DE-378)

NASA Technical Reports Server (NTRS)

Kelly, Mark W.; Smaus, Louis H.

1952-01-01

A l/4-scale dynamically similar model of the XFV-1 airplane has been flown in the Ames 40- by 80-foot wind tunnel, using the trailing flight-cable technique. This investigation was devoted to establishing the flight characteristics of the model in forward flight from hovering to wing stall, and in yawed flight (wing span alined with the relative wind) from hovering to the maximum speed at which controlled flight could be maintained. Landings, take-offs, and hovering characteristics in flights close to the ground were also investigated.. Since the remote control system for the model was rather complicated and provided artificial damping about the pitch, roll, and yaw axes, sufficient data from the control-system calibration tests are included in this report to specify the performance of the control system in relation to both the model flight tests and the design of an automatic control system for the full-scale airplane. The model in hovering flight appeared to be neutrally stable. The response of the model to the controls was very rapid, and it was always necessary to provide some amount of artificial damping to maintain control. The model could be landed with little difficulty by hovering approximately a foot above the floor and then cutting the power. Take-offs were more difficult to perform, primarily because the rate of change in power to the model motors was limited by the characteristics of the available power source. The model was,capable of controlled yawed flight at translational velocities up to and including 20 feet per second. The effectiveness of the controls decreased with increasing speed, however, and at 25 fps control in pitch, and probably roll, was lost completely. The model was flown in controlled forward flight from hovering up to 70 fps. During these flights the model appeared to be more difficult to control in yaw than it was in pitch or roll. The flights of the model were recorded by motion picture cameras. These motion pictures are available on loan from NACA Headquarters as a film supplement to this report.

Full-Scaled Advanced Systems Testbed: Ensuring Success of Adaptive Control Research Through Project Lifecycle Risk Mitigation

NASA Technical Reports Server (NTRS)

Pavlock, Kate M.

2011-01-01

The National Aeronautics and Space Administration's Dryden Flight Research Center completed flight testing of adaptive controls research on the Full-Scale Advance Systems Testbed (FAST) in January of 2011. The research addressed technical challenges involved with reducing risk in an increasingly complex and dynamic national airspace. Specific challenges lie with the development of validated, multidisciplinary, integrated aircraft control design tools and techniques to enable safe flight in the presence of adverse conditions such as structural damage, control surface failures, or aerodynamic upsets. The testbed is an F-18 aircraft serving as a full-scale vehicle to test and validate adaptive flight control research and lends a significant confidence to the development, maturation, and acceptance process of incorporating adaptive control laws into follow-on research and the operational environment. The experimental systems integrated into FAST were designed to allow for flexible yet safe flight test evaluation and validation of modern adaptive control technologies and revolve around two major hardware upgrades: the modification of Production Support Flight Control Computers (PSFCC) and integration of two, fourth-generation Airborne Research Test Systems (ARTS). Post-hardware integration verification and validation provided the foundation for safe flight test of Nonlinear Dynamic Inversion and Model Reference Aircraft Control adaptive control law experiments. To ensure success of flight in terms of cost, schedule, and test results, emphasis on risk management was incorporated into early stages of design and flight test planning and continued through the execution of each flight test mission. Specific consideration was made to incorporate safety features within the hardware and software to alleviate user demands as well as into test processes and training to reduce human factor impacts to safe and successful flight test. This paper describes the research configuration, experiment functionality, overall risk mitigation, flight test approach and results, and lessons learned of adaptive controls research of the Full-Scale Advanced Systems Testbed.

Flight control system design factors for applying automated testing techniques

NASA Technical Reports Server (NTRS)

Sitz, Joel R.; Vernon, Todd H.

1990-01-01

Automated validation of flight-critical embedded systems is being done at ARC Dryden Flight Research Facility. The automated testing techniques are being used to perform closed-loop validation of man-rated flight control systems. The principal design features and operational experiences of the X-29 forward-swept-wing aircraft and F-18 High Alpha Research Vehicle (HARV) automated test systems are discussed. Operationally applying automated testing techniques has accentuated flight control system features that either help or hinder the application of these techniques. The paper also discusses flight control system features which foster the use of automated testing techniques.

Post-Flight Analysis of the Guidance, Navigation, and Control Performance During Orion Exploration Flight Test 1

NASA Technical Reports Server (NTRS)

Barth, Andrew; Mamich, Harvey; Hoelscher, Brian

2015-01-01

The first test flight of the Orion Multi-Purpose Crew Vehicle presented additional challenges for guidance, navigation and control as compared to a typical re-entry from the International Space Station or other Low Earth Orbit. An elevated re-entry velocity and steeper flight path angle were chosen to achieve aero-thermal flight test objectives. New IMU's, a GPS receiver, and baro altimeters were flight qualified to provide the redundant navigation needed for human space flight. The guidance and control systems must manage the vehicle lift vector in order to deliver the vehicle to a precision, coastal, water landing, while operating within aerodynamic load, reaction control system, and propellant constraints. Extensive pre-flight six degree-of-freedom analysis was performed that showed mission success for the nominal mission as well as in the presence of sensor and effector failures. Post-flight reconstruction analysis of the test flight is presented in this paper to show whether that all performance metrics were met and establish how well the pre-flight analysis predicted the in-flight performance.

Mentoring SFRM: A New Approach to International Space Station Flight Control Training

NASA Technical Reports Server (NTRS)

Huning, Therese; Barshi, Immanuel; Schmidt, Lacey

2009-01-01

The Mission Operations Directorate (MOD) of the Johnson Space Center is responsible for providing continuous operations support for the International Space Station (ISS). Operations support requires flight controllers who are skilled in team performance as well as the technical operations of the ISS. Space Flight Resource Management (SFRM), a NASA adapted variant of Crew Resource Management (CRM), is the competency model used in the MOD. ISS flight controller certification has evolved to include a balanced focus on development of SFRM and technical expertise. The latest challenge the MOD faces is how to certify an ISS flight controller (Operator) to a basic level of effectiveness in 1 year. SFRM training uses a twopronged approach to expediting operator certification: 1) imbed SFRM skills training into all Operator technical training and 2) use senior flight controllers as mentors. This paper focuses on how the MOD uses senior flight controllers as mentors to train SFRM skills.

STS-125 Flight Controllers on Console - (Orbit Shift 1). Flight Director: Anthony Ceccacci

NASA Image and Video Library

2009-05-14

JSC2009-E-120480 (14 May 2009) --- Tomas Gonzalez-Torres, STS-125 lead spacewalk officer, monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day four activities.

STS-125 Flight Controllers on Console - (Orbit Shift 1). Flight Director: Anthony Ceccacci

NASA Image and Video Library

2009-05-14

JSC2009-E-120486 (14 May 2009) --- Tomas Gonzalez-Torres, STS-125 lead spacewalk officer, monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day four activities.

STS-132/ULF4 Flight Controllers on Console - Bldg. 30 south

NASA Image and Video Library

2010-05-20

JSC2010-E-086341 (20 May 2010) --- ISS flight director Holly Ridings monitors data at her console in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132/ULF-4 mission flight day seven activities.

STS-125 Flight Controllers on Console - (Orbit Shift 1). Flight Director: Anthony Ceccacci

NASA Image and Video Library

2009-05-14

JSC2009-E-120489 (14 May 2009) --- Astronaut Dan Burbank, STS-125 spacecraft communicator (CAPCOM), monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day four activities.

Studying time of flight imaging through scattering media across multiple size scales (Conference Presentation)

NASA Astrophysics Data System (ADS)

Velten, Andreas

2017-05-01

Light scattering is a primary obstacle to optical imaging in a variety of different environments and across many size and time scales. Scattering complicates imaging on large scales when imaging through the atmosphere when imaging from airborne or space borne platforms, through marine fog, or through fog and dust in vehicle navigation, for example in self driving cars. On smaller scales, scattering is the major obstacle when imaging through human tissue in biomedical applications. Despite the large variety of participating materials and size scales, light transport in all these environments is usually described with very similar scattering models that are defined by the same small set of parameters, including scattering and absorption length and phase function. We attempt a study of scattering and methods of imaging through scattering across different scales and media, particularly with respect to the use of time of flight information. We can show that using time of flight, in addition to spatial information, provides distinct advantages in scattering environments. By performing a comparative study of scattering across scales and media, we are able to suggest scale models for scattering environments to aid lab research. We also can transfer knowledge and methodology between different fields.

Flight Test Approach to Adaptive Control Research

NASA Technical Reports Server (NTRS)

Pavlock, Kate Maureen; Less, James L.; Larson, David Nils

2011-01-01

The National Aeronautics and Space Administration s Dryden Flight Research Center completed flight testing of adaptive controls research on a full-scale F-18 testbed. The validation of adaptive controls has the potential to enhance safety in the presence of adverse conditions such as structural damage or control surface failures. This paper describes the research interface architecture, risk mitigations, flight test approach and lessons learned of adaptive controls research.

Mechanization of and experience with a triplex fly-by-wire backup control system

NASA Technical Reports Server (NTRS)

Lock, W. P.; Petersen, W. R.; Whitman, G. B.

1975-01-01

A redundant three-axis analog control system was designed and developed to back up a digital fly-by-wire control system for an F-8C airplane. Forty-two flights, involving 58 hours of flight time, were flown by six pilots. The mechanization and operational experience with the backup control system, the problems involved in synchronizing it with the primary system, and the reliability of the system are discussed. The backup control system was dissimilar to the primary system, and it provided satisfactory handling through the flight envelope evaluated. Limited flight tests of a variety of control tasks showed that control was also satisfactory when the backup control system was controlled by a minimum-displacement (force) side stick. The operational reliability of the F-8 digital fly-by-wire control system was satisfactory, with no unintentional downmodes to the backup control system in flight. The ground and flight reliability of the system's components is discussed.

Excitations for Rapidly Estimating Flight-Control Parameters

NASA Technical Reports Server (NTRS)

Moes, Tim; Smith, Mark; Morelli, Gene

2006-01-01

A flight test on an F-15 airplane was performed to evaluate the utility of prescribed simultaneous independent surface excitations (PreSISE) for real-time estimation of flight-control parameters, including stability and control derivatives. The ability to extract these derivatives in nearly real time is needed to support flight demonstration of intelligent flight-control system (IFCS) concepts under development at NASA, in academia, and in industry. Traditionally, flight maneuvers have been designed and executed to obtain estimates of stability and control derivatives by use of a post-flight analysis technique. For an IFCS, it is required to be able to modify control laws in real time for an aircraft that has been damaged in flight (because of combat, weather, or a system failure). The flight test included PreSISE maneuvers, during which all desired control surfaces are excited simultaneously, but at different frequencies, resulting in aircraft motions about all coordinate axes. The objectives of the test were to obtain data for post-flight analysis and to perform the analysis to determine: 1) The accuracy of derivatives estimated by use of PreSISE, 2) The required durations of PreSISE inputs, and 3) The minimum required magnitudes of PreSISE inputs. The PreSISE inputs in the flight test consisted of stacked sine-wave excitations at various frequencies, including symmetric and differential excitations of canard and stabilator control surfaces and excitations of aileron and rudder control surfaces of a highly modified F-15 airplane. Small, medium, and large excitations were tested in 15-second maneuvers at subsonic, transonic, and supersonic speeds. Typical excitations are shown in Figure 1. Flight-test data were analyzed by use of pEst, which is an industry-standard output-error technique developed by Dryden Flight Research Center. Data were also analyzed by use of Fourier-transform regression (FTR), which was developed for onboard, real-time estimation of the derivatives.

78 FR 53237 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... control secondary computers (FCSCs), rather than flight control primary computers (FCPCs). This document... control primary computers (FCPCs); modifying two flight control secondary computers (FCSCs); revising the... the AD, which specify FCSCs, instead of flight control primary computers FCPCs. No other part of the...

Gravity Sensors and the Role of 3-D Visualization and Simulation in Biomedical Research

NASA Technical Reports Server (NTRS)

Ross, Muriel D.

1995-01-01

Ross 3.0 software was developed in the Biocomputation Center for semi-automated reconstruction of objects from serial thin sections. Data are captured directly from a transmission electron microscope via a video camera to a graphics workstation where the sections are mosaicked and contours are traced, registered and displayed by semi-automated methods. For the first time, macular type II cells are described completely for their innervation patterns. The purposes are to learn more about the fundamental circuitry of the macula and to demonstrate whether the terminals are altered morphologically by space flight. Current examples, from the medial part of the macula, are from maculas collected in-flight on the Space Life Sciences-2 mission, 4.5 hrs post-flight, and from a ground control. Results show that the typical type 11 cell receives processes from up to six nearby calyces or afferents. Nearly all the processes are elongated; some have bouton-like swellings and numerous vesicles. Multiple (2 to 4) processes from a single calyx to a type II cell are common, and approx. 1/3 of the processes innervate 2 type II cells of a neighboring cluster of 3 cells. About 2% of type II cells resemble type I cells morphologically and are surrounded by demicalyces. Differences in size or shape of the terminals under flight conditions could not be determined because the sample size is still too small; but it is clear that reconstruction methods provide insights into macular circuitry not obtainable by other techniques. The results demonstrate a morphological basis for interactions between adjacent receptive fields, through feedback-feedforward connections, during preprocessing of linear acceleratory information by the maculas. While the methods are currently being tested using vestibular maculas as the model system, it is clear that the technology is applicable to any tissue that can be physically or optically sectioned. ROSS software has already been implemented for reconstructing objects from tissues studied by confocal and by transmitted light microscopy, and research into magnetic resonance imaging-computational tomography combined visualization are underway.

STS-125 Flight Controllers on Console - (Orbit Shift 2). Flight Director: Richard LaBrode

NASA Image and Video Library

2009-05-12

JSC2009-E-119378 (12 May 2009) --- Tomas Gonzalez-Torres, STS-125 lead spacewalk officer, monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day two activities.

STS-132/ULF4 Flight Controllers on Console

NASA Image and Video Library

2010-05-18

JSC2010-E-081916 (18 May 2010) --- ISS flight directors Holly Ridings (seated) and Emily Nelson monitor data at their console in the space station flight control room in the Mission Control Center at NASA's Johnson Space Center during STS-132/ULF-4 mission flight day five activities.

STS-125 Flight Controllers on Console During HST Grapple - Orbit 1. Flight Director: Tony Ceccacci

NASA Image and Video Library

2009-05-13

JSC2009-E-119633 (13 May 2009) --- Astronaut Dan Burbank, STS-125 spacecraft communicator (CAPCOM), monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day three activities.

STS-125 Flight Controllers on Console - (Orbit Shift 2). Flight Director: Richard LaBrode

NASA Image and Video Library

2009-05-12

JSC2009-E-119391 (12 May 2009) --- Astronaut Alan Poindexter, STS-125 spacecraft communicator (CAPCOM), monitors data at his console in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day two activities.

STS-109 Flight Control Team Photo in WFCR - Orbit 2 with Flight Director Tony Ceccaci.

NASA Image and Video Library

2002-03-05

JSC2002-00574 (5 March 2002) --- The members of the STS-109 Orbit 2 Team pose for a group portrait in the shuttle flight control room (WFCR) in Houston's Mission Control Center (MCC). Flight director Tony Ceccacci holds the STS-109 mission logo.

Launch vehicle flight control augmentation using smart materials and advanced composites (CDDF Project 93-05)

NASA Technical Reports Server (NTRS)

Barret, C.

1995-01-01

The Marshall Space Flight Center has a rich heritage of launch vehicles that have used aerodynamic surfaces for flight stability such as the Saturn vehicles and flight control such as on the Redstone. Recently, due to aft center-of-gravity locations on launch vehicles currently being studied, the need has arisen for the vehicle control augmentation that is provided by these flight controls. Aerodynamic flight control can also reduce engine gimbaling requirements, provide actuator failure protection, enhance crew safety, and increase vehicle reliability, and payload capability. In the Saturn era, NASA went to the Moon with 300 sq ft of aerodynamic surfaces on the Saturn V. Since those days, the wealth of smart materials and advanced composites that have been developed allow for the design of very lightweight, strong, and innovative launch vehicle flight control surfaces. This paper presents an overview of the advanced composites and smart materials that are directly applicable to launch vehicle control surfaces.

Simulation Training Versus Real Time Console Training for New Flight Controllers

NASA Technical Reports Server (NTRS)

Heaton, Amanda

2010-01-01

For new flight controllers, the two main learning tools are simulations and real time console performance training. These benefit the new flight controllers in different ways and could possibly be improved. Simulations: a) Allow for mistakes without serious consequences. b) Lets new flight controllers learn the working style of other new flight controllers. c) Lets new flight controllers eventually begin to feel like they have mastered the sim world, so therefore they must be competent in the real time world too. Real time: a) Shows new flight controllers some of the unique problems that develop and have to be accounted for when dealing with certain payloads or systems. b) Lets new flight controllers experience handovers - gathering information from the previous shift on what the room needs to be aware of and what still needs to be done. c) Gives new flight controllers confidence that they can succeed in the position they are training for when they can solve real anomalies. How Sims could be improved and more like real-time ops for the ISS Operations Controller position: a) Operations Change Requests to review. b) Fewer anomalies (but still more than real time for practice). c) Payload Planning Manager Handover sheet for the E-1 and E-3 reviews. d) Flight note in system with at least one comment to verify for the E-1 and E-3 reviews How the real time console performance training could be improved for the ISS Operations Controller position: a) Schedule the new flight controller to be on console for four days but with a different certified person each day. This will force them to be the source of knowledge about every OCR in progress, everything that has happened in those few days, and every activity on the timeline. Constellation program flight controllers will have to learn entirely from simulations, thereby losing some of the elements that they will need to have experience with for real time ops. It may help them to practice real time console performance training in the International Space Station or Space Shuttle to gather some general anomaly resolution and day-to-day task management skills.

The Right Stuff: A Look Back at Three Decades of Flight Controller Training for Space Shuttle Mission Operations

NASA Technical Reports Server (NTRS)

Dittemore, Gary D.; Bertels, Christie

2010-01-01

This paper will summarize the thirty-year history of Space Shuttle operations from the perspective of training in NASA Johnson Space Center's Mission Control Center. It will focus on training and development of flight controllers and instructors, and how training practices have evolved over the years as flight experience was gained, new technologies developed, and programmatic needs changed. Operations of human spaceflight systems is extremely complex, therefore the training and certification of operations personnel is a critical piece of ensuring mission success. Mission Control Center (MCC-H), at the Lyndon B. Johnson Space Center, in Houston, Texas manages mission operations for the Space Shuttle Program, including the training and certification of the astronauts and flight control teams. This paper will give an overview of a flight control team s makeup and responsibilities during a flight, and details on how those teams are trained and certified. The training methodology for developing flight controllers has evolved significantly over the last thirty years, while the core goals and competencies have remained the same. In addition, the facilities and tools used in the control center have evolved. These changes have been driven by many factors including lessons learned, technology, shuttle accidents, shifts in risk posture, and generational differences. Flight controllers will share their experiences in training and operating the Space Shuttle throughout the Program s history. A primary method used for training Space Shuttle flight control teams is by running mission simulations of the orbit, ascent, and entry phases, to truly "train like you fly." The audience will learn what it is like to perform a simulation as a shuttle flight controller. Finally, we will reflect on the lessons learned in training for the shuttle program, and how those could be applied to future human spaceflight endeavors.

Measurement of OH, NO, O and N atoms in helium plasma jet for ROS/RNS controlled biomedical processes

NASA Astrophysics Data System (ADS)

Yonemori, Seiya; Kamakura, Taku; Ono, Ryo

2014-10-01

Atmospheric-pressure plasmas are of emerging interest for new plasma applications such as cancer treatment, cell activation and sterilization. In those biomedical processes, reactive oxygen/nitrogen species (ROS/RNS) are said that they play significant role. It is though that active species give oxidative stress and induce biomedical reactions. In this study, we measured OH, NO, O and N atoms using laser induced fluorescence (LIF) measurement and found that voltage polarity affect particular ROS. When negative high voltage was applied to the plasma jet, O atom density was tripled compared to the case of positive applied voltage. In that case, O atom density was around 3 × 1015 [cm-3] at maximum. In contrast, OH and NO density did not change their density depending on the polarity of applied voltage, measured as in order of 1013 and 1014 [cm-3] at maximum, respectively. From ICCD imaging measurement, it could be seen that negative high voltage enhanced secondary emission in plasma bullet propagation and it can affect the effective production of particular ROS. Since ROS/RNS dose can be a quantitative criterion to control plasma biomedical application, those measurement results is able to be applied for in vivo and in vitro plasma biomedical experiments. This study is supported by the Grant-in-Aid for Science Research by the Ministry of Education, Culture, Sport, Science and Technology.

Photoreconfigurable polymers for biomedical applications: chemistry and macromolecular engineering.

PubMed

Zhu, Congcong; Ninh, Chi; Bettinger, Christopher J

2014-10-13

Stimuli-responsive polymers play an important role in many biomedical technologies. Light responsive polymers are particularly desirable because the parameters of irradiated light and diverse photoactive chemistries produce a large number of combinations between functional materials and associated stimuli. This Review summarizes recent advances in utilizing photoactive chemistries in macromolecules for prospective use in biomedical applications. Special focus is granted to selection criterion when choosing photofunctional groups. Synthetic strategies to incorporate these functionalities into polymers and networks with different topologies are also highlighted herein. Prospective applications of these materials are discussed including programmable matrices for controlled release, dynamic scaffolds for tissue engineering, and functional coatings for medical devices. The article concludes by summarizing the state of the art in photoresponsive polymers for biomedical applications including current challenges and future opportunities.

International Space Station as Analog of Interplanetary Transit Vehicle For Biomedical Research

NASA Technical Reports Server (NTRS)

Charles, John B.

2012-01-01

Astronaut missions lasting up to six months aboard the International Space Station (ISS) have much in common with interplanetary flights, especially the outbound, Earth-to-Mars transit portion of a Mars mission. Utilization of ISS and other appropriate platforms to prepare for crewed expeditions to planetary destinations including Mars has been the work of NASA's Human Research Program (HRP) since 2005. HRP is charged specifically to understand and reduced the risks to astronaut health and performance in space exploration missions: everything HRP does and has done is directly related to that responsibility. Two major categories of human research have capitalized on ISS capabilities. The first category centers on the biomedical aspects of long-duration exposure to spaceflight factors, including prolonged weightlessness, radiation exposure, isolation and confinement, and actual risk to life and limb. These studies contribute to astronaut safety, health and efficiency on any long-duration missions, whether in low Earth orbit (LEO) or beyond. Qualitatively, weightlessness is weightlessness, whether in LEO or en route to Mars. The HRP sponsors investigations into losses in muscle and bone integrity, cardiovascular function, sensory-motor capability, immune capacity and psychosocial health, and development and demonstration of appropriate treatments and preventative measures. The second category includes studies that are focused on planetary expeditions beyond LEO. For these, ISS offers a high fidelity analog to investigate the combined effects of spaceflight factors (described above) plus the isolation and autonomy associated with simulated increasing distance from Earth. Investigations address crew cohesion, performance and workload, and mission control performance. The behavioral health and performance and space human factors aspects of planetary missions dominate this category. Work has already begun on a new investigation in this category which will examine the effects of a simulated lag in communications (mimicking that expected in transit to Mars) on astronaut performance aboard ISS. Extension of the current ISS increment duration from six months to nine or even twelve months would provide opportunities for expanded research relevant to long duration missions, albeit at the cost of fewer astronauts as subjects for those investigations. Given the possible limited access to ISS after 2020, if ISS is intended to facilitate future exploration missions, then the in-flight human investigations should focus on those that clearly enable future exploration missions.

Judging The Efficacy of Anthrax Fumigations

DTIC Science & Technology

2003-11-20

FUMIGATIONS IN RESPONSE TO 2001 ANTHRAX ATTACKS Most fumigations modeled after biomedical sterilization processes, with established ranges for process...exposure to VHP All BIs recovered aseptically negative for growth of B. stearothermophilus Positive control BIs (5% of BIs) demonstrate growth Negative...of 10 zones was re-fumigated; second fumigation met all requirements HISTORICAL CRITERIA FOR SUCCESSFUL TREATMENT Biomedical sterilizations – FDA

New Biomedical Technologies and Strategies for Prevention of HIV and Other Sexually Transmitted Infections

PubMed Central

2016-01-01

Sexually transmitted infections remain to be of public health concern in many developing countries. Their control is important, considering the high incidence of acute infections, complications and sequelae, and their socioeconomic impact. This article discusses the new biomedical technologies and strategies for the prevention of HIV and other sexually transmitted infections. PMID:27703837

STS-116/ISS 12A.1 flight controllers on console during EVA #4

NASA Image and Video Library

2006-12-18

JSC2006-E-54436 (18 Dec. 2006) --- ISS lead flight director John Curry (right) and astronaut Stephen K. Robinson, at the CAPCOM console, represent part of the busy ground support effort for the add-on spacewalk by the STS-116 crew. Astronaut Joseph R. Tanner, who like Robinson is a veteran of multiple space walks, assisted with CAPCOM duties. While flight controllers in this space station flight control room were busy supporting the spacewalk, so were their counterparts in the space shuttle flight control room, not far away in the Johnson Space Center's Mission Control Center.

Flight Control of Biomimetic Air Vehicles Using Vibrational Control and Averaging

NASA Astrophysics Data System (ADS)

Tahmasian, Sevak; Woolsey, Craig A.

2017-08-01

A combination of vibrational inputs and state feedback is applied to control the flight of a biomimetic air vehicle. First, a control strategy is developed for longitudinal flight, using a quasi-steady aerodynamic model and neglecting wing inertial effects. Vertical and forward motion is controlled by modulating the wings' stroke and feather angles, respectively. Stabilizing control parameter values are determined using the time-averaged dynamic model. Simulations of a system resembling a hawkmoth show that the proposed controller can overcome modeling error associated with the wing inertia and small parameter uncertainties when following a prescribed trajectory. After introducing the approach through an application to longitudinal flight, the control strategy is extended to address flight in three-dimensional space.

Total energy based flight control system

NASA Technical Reports Server (NTRS)

Lambregts, Antonius A. (Inventor)

1985-01-01

An integrated aircraft longitudinal flight control system uses a generalized thrust and elevator command computation (38), which accepts flight path angle, longitudinal acceleration command signals, along with associated feedback signals, to form energy rate error (20) and energy rate distribution error (18) signals. The engine thrust command is developed (22) as a function of the energy rate distribution error and the elevator position command is developed (26) as a function of the energy distribution error. For any vertical flight path and speed mode the outerloop errors are normalized (30, 34) to produce flight path angle and longitudinal acceleration commands. The system provides decoupled flight path and speed control for all control modes previously provided by the longitudinal autopilot, autothrottle and flight management systems.

Biomedical experiments. Part A: Biostack experiment

NASA Technical Reports Server (NTRS)

Buecker, H.; Horneck, G.; Reinholz, E.; Scheuermann, W.; Ruether, W.; Graul, E. H.; Planel, H.; Soleilhavoup, J. P.; Cuer, P.; Kaiser, R.

1972-01-01

The biostack experiment is described which was designed to study the biologic effects of individual heavy nuclei of galactic cosmic radiation during space flight outside the magnetosphere of the earth. Specifically, the biostack experiment was designed to promote research on the effects of high energy/high Z particles of galactic cosmic radiation on a broad spectrum of biologic systems, from the molecular to the highly organized and developed forms of life. The experiment was considered unique and scientifically meritorious because of its potential yield of information - currently unavailable on earth - on the interaction of biologic systems with the heavy particles of galactic cosmic radiation.

Digital flight control actuation system study

NASA Technical Reports Server (NTRS)

Rossing, R.; Hupp, R.

1974-01-01

Flight control actuators and feedback sensors suitable for use in a redundant digital flight control system were examined. The most appropriate design approach for an advanced digital flight control actuation system for development and use in a fly-by-wire system was selected. The concept which was selected consisted of a PM torque motor direct drive. The selected system is compatible with concurrent and independent development efforts on the computer system and the control law mechanizations.

The B-747 flight control system maintenance and reliability data base for cost effectiveness tradeoff studies

NASA Technical Reports Server (NTRS)

1982-01-01

Primary and automatic flight controls are combined for a total flight control reliability and maintenance cost data base using information from two previous reports and additional cost data gathered from a major airline. A comparison of the current B-747 flight control system effects on reliability and operating cost with that of a B-747 designed for an active control wing load alleviation system is provided.

Human factors implications of unmanned aircraft accidents : flight-control problems

DOT National Transportation Integrated Search

2006-04-01

This research focuses on three types of flight control problems associated with unmanned aircraft systems. The : three flight control problems are: 1) external pilot difficulties with inconsistent mapping of the controls to the : movement of the airc...

Implementation of an Adaptive Controller System from Concept to Flight Test

NASA Technical Reports Server (NTRS)

Larson, Richard R.; Burken, John J.; Butler, Bradley S.

2009-01-01

The National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California) is conducting ongoing flight research using adaptive controller algorithms. A highly modified McDonnell-Douglas NF-15B airplane called the F-15 Intelligent Flight Control System (IFCS) was used for these algorithms. This airplane has been modified by the addition of canards and by changing the flight control systems to interface a single-string research controller processor for neural network algorithms. Research goals included demonstration of revolutionary control approaches that can efficiently optimize aircraft performance for both normal and failure conditions, and to advance neural-network-based flight control technology for new aerospace systems designs. Before the NF-15B IFCS airplane was certified for flight test, however, certain processes needed to be completed. This paper presents an overview of these processes, including a description of the initial adaptive controller concepts followed by a discussion of modeling formulation and performance testing. Upon design finalization, the next steps are: integration with the system interfaces, verification of the software, validation of the hardware to the requirements, design of failure detection, development of safety limiters to minimize the effect of erroneous neural network commands, and creation of flight test control room displays to maximize human situational awareness.

Flight Test Results on the Stability and Control of the F-15 Quiet Spike(TradeMark) Aircraft

NASA Technical Reports Server (NTRS)

Moua, Cheng M.; McWherter, Shaun C.; Cox, Timothy H.; Gera, Joe

2012-01-01

The Quiet Spike F-15B flight research program investigated supersonic shock reduction using a 24-ft sub-scale telescoping nose boom on an F-15B airplane. The program primary flight test objective was to collect flight data for aerodynamic and structural models validation up to 1.8 Mach. Other objectives were to validate the mechanical feasibility of a morphing fuselage at the operational conditions and determine the near-field shock wave characterization. The stability and controls objectives were to assess the effect of the spike on the stability, controllability, and handling qualities of the aircraft and to ensure adequate stability margins across the entire research flight envelop. The two main stability and controls issues were the effects of the telescoping nose boom influenced aerodynamics on the F-15B aircraft flight dynamics and air data and angle of attack sensors. This paper reports on the stability and controls flight envelope clearance methods and flight test analysis of the F-15B Quiet Spike. Brief pilot commentary on typical piloting tasks, approach and landing, refueling task, and air data sensitivity to the flight control system are also discussed in this report.

14 CFR 415.127 - Flight safety system design and operation data.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Expendable Launch Vehicle From a Non-Federal Launch Site § 415.127 Flight safety system design and operation...: flight termination system; command control system; tracking; telemetry; communications; flight safety... control system. (7) Flight termination system component storage, operating, and service life. A listing of...

Advances in Thrust-Based Emergency Control of an Airplane

NASA Technical Reports Server (NTRS)

Creech, Gray; Burken, John J.; Burcham, Bill

2003-01-01

Engineers at NASA's Dryden Flight Research Center have received a patent on an emergency flight-control method implemented by a propulsion-controlled aircraft (PCA) system. Utilizing the preexisting auto-throttle and engine-pressure-ratio trim controls of the airplane, the PCA system provides pitch and roll control for landing an airplane safely without using aerodynamic control surfaces that have ceased to function because of a primary-flight-control-system failure. The installation of the PCA does not entail any changes in pre-existing engine hardware or software. [Aspects of the method and system at previous stages of development were reported in Thrust-Control System for Emergency Control of an Airplane (DRC-96-07), NASA Tech Briefs, Vol. 25, No. 3 (March 2001), page 68 and Emergency Landing Using Thrust Control and Shift of Weight (DRC-96-55), NASA Tech Briefs, Vol. 26, No. 5 (May 2002), page 58.]. Aircraft flight-control systems are designed with extensive redundancy to ensure low probabilities of failure. During recent years, however, several airplanes have exhibited major flight-control-system failures, leaving engine thrust as the last mode of flight control. In some of these emergency situations, engine thrusts were successfully modulated by the pilots to maintain flight paths or pitch angles, but in other situations, lateral control was also needed. In the majority of such control-system failures, crashes resulted and over 1,200 people died. The challenge lay in creating a means of sufficient degree of thrust-modulation control to safely fly and land a stricken airplane. A thrust-modulation control system designed for this purpose was flight-tested in a PCA an MD-11 airplane. The results of the flight test showed that without any operational control surfaces, a pilot can land a crippled airplane (U.S. Patent 5,330,131). The installation of the original PCA system entailed modifications not only of the flight-control computer (FCC) of the airplane but also of each engine-control computer. Inasmuch as engine-manufacturer warranties do not apply to modified engines, the challenge became one of creating a PCA system that does not entail modifications of the engine computers.

Design and simulation of flight control system for man-portable micro reconnaissance quadcopter

NASA Astrophysics Data System (ADS)

Yin, Xinfan; Zhang, Daibing; Fang, Qiang; Shen, Lincheng

2017-10-01

The quadcopter has been widely used in the field of aerial photography and environmental detection, because of its advantages of VTOL, simple structure, and easy-control. In the field of urban anti-terrorism or special operations, micro reconnaissance quadcpter has its unique advantages such as all-weather taking off and landing, small noise and so on, and it is very popular with special forces and riot police. This paper aims at the flight control problem of the micro quadcopter, for the purposes of attitude stabilization control and trajectory tracking control of the micro quadcopter, first, the modeling of the micro quadcopter is presented. And using the MATLAB/SIMULINK toolbox to build the flight controller of the micro quadcopter, and then simulation analysis and real flight test are given. The results of the experiment show that the designed PID controller can correct the flight attitude shift effectively and track the planned tracks well, and can achieve the goal of stable and reliable flight of the quadcopter. It can be a useful reference for the flight control system design of future special operations micro UAV.

The Effect of Lateral-Directional Control Coupling on Pilot Control of an Airplane as Determined in Flight and in a Fixed-Base Flight Simulator

NASA Technical Reports Server (NTRS)

Vomaske, Richard F.; Sadoff, Melvin; Drinkwater, Fred J., III

1961-01-01

A flight and fixed-base simulator study was made of the effects of aileron-induced yaw on pilot opinion of aircraft lateral-directional controllability characteristics. A wide range of adverse and favorable aileron-induced yaw was investigated in flight at several levels of Dutch-roll damping. The flight results indicated that the optimum values of aileron- induced yaw differed only slightly from zero for Dutch-roll damping from satisfactory to marginally controllable levels. It was also shown that each range of values of aileron-induced yawing moment considered satisfactory, acceptable, or controllable increased with an increase in the Dutch- roll damping. The increase was most marked for marginally controllable configurations exhibiting favorable aileron-induced yaw. Comparison of fixed-base flight simulator results with flight results showed agreement, indicating that absence of kinesthetic motion cues did not markedly affect the pilots' evaluation of the type of control problem considered in this study. The results of the flight study were recast in terms of several parameters which were considered to have an important effect on pilot opinion of lateral-directional handling qualities, including the effects of control coupling. Results of brief tests with a three-axis side-arm controller indicated that for control coupling problems associated with highly favorable yaw and cross-control techniques, use of the three-axis controller resulted in a deterioration of control relative to results obtained with the conventional center stick and rudder pedals.

14 CFR 125.311 - Flight crewmembers at controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight crewmembers at controls. 125.311... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Operations § 125.311 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each...

14 CFR 125.311 - Flight crewmembers at controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight crewmembers at controls. 125.311... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Operations § 125.311 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each...

14 CFR 125.311 - Flight crewmembers at controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight crewmembers at controls. 125.311... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Operations § 125.311 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each...

75 FR 3959 - Fifth Meeting-RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220: Automatic Flight Guidance and Control meeting. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 220: Automatic Flight...

75 FR 15770 - Sixth Meeting-RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

... 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220: Automatic Flight Guidance and Control meeting. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 220: Automatic Flight...

76 FR 22163 - Tenth Meeting: RTCA Special Committee 220: Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220 meeting: Automatic Flight Guidance and Control. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 220: Automatic Flight...

14 CFR 125.311 - Flight crewmembers at controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight crewmembers at controls. 125.311... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Operations § 125.311 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each...

STS-132/ULF4 Flight Controllers on Console

NASA Image and Video Library

2010-05-18

JSC2010-E-081909 (18 May 2010) --- Flight director Mike Sarafin (left) and NASA astronaut Chris Cassidy, spacecraft communicator (CAPCOM) for the STS-132 mission, are pictured at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day five activities.

14 CFR 125.311 - Flight crewmembers at controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight crewmembers at controls. 125.311... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Flight Operations § 125.311 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each...

STS-132/ULF4 Flight Controllers on Console - Orbit 2

NASA Image and Video Library

2010-05-17

JSC2010-E-084271 (17 May 2010) --- Flight director Chris Edelen (right) and NASA astronaut Stanley Love, spacecraft communicator (CAPCOM) for the STS-132 mission, are pictured at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day four activities.

A unified flight control methodology for a compound rotorcraft in fundamental and aerobatic maneuvering flight

NASA Astrophysics Data System (ADS)

Thorsen, Adam

This study investigates a novel approach to flight control for a compound rotorcraft in a variety of maneuvers ranging from fundamental to aerobatic in nature. Fundamental maneuvers are a class of maneuvers with design significance that are useful for testing and tuning flight control systems along with uncovering control law deficiencies. Aerobatic maneuvers are a class of aggressive and complex maneuvers with more operational significance. The process culminating in a unified approach to flight control includes various control allocation studies for redundant controls in trim and maneuvering flight, an efficient methodology to simulate non-piloted maneuvers with varying degrees of complexity, and the setup of an unconventional control inceptor configuration along with the use of a flight simulator to gather pilot feedback in order to improve the unified control architecture. A flight path generation algorithm was developed to calculate control inceptor commands required for a rotorcraft in aerobatic maneuvers. This generalized algorithm was tailored to generate flight paths through optimization methods in order to satisfy target terminal position coordinates or to minimize the total time of a particular maneuver. Six aerobatic maneuvers were developed drawing inspiration from air combat maneuvers of fighter jet aircraft: Pitch-Back Turn (PBT), Combat Ascent Turn (CAT), Combat Descent Turn (CDT), Weaving Pull-up (WPU), Combat Break Turn (CBT), and Zoom and Boom (ZAB). These aerobatic maneuvers were simulated at moderate to high advance ratios while fundamental maneuvers of the compound including level accelerations/decelerations, climbs, descents, and turns were investigated across the entire flight envelope to evaluate controller performance. The unified control system was developed to allow controls to seamlessly transition between manual and automatic allocations while ensuring that the axis of control for a particular inceptor remained constant with flight regime. An energy management system was developed in order to manage performance limits (namely power required) to promote carefree maneuvering and alleviate pilot workload. This system features limits on pilot commands and has additional logic for preserving control margins and limiting maximum speed in a dive. Nonlinear dynamic inversion (NLDI) is the framework of the unified controller, which incorporates primary and redundant controls. The inner loop of the NLDI controller regulates bank angle, pitch attitude, and yaw rate, while the outer loop command structure is varied (three modes). One version uses an outer loop that commands velocities in the longitudinal and vertical axes (velocity mode), another commands longitudinal acceleration and vertical speed (acceleration mode), and the third commands longitudinal acceleration and transitions from velocity to acceleration command in the vertical axis (aerobatic mode). The flight envelope is discretized into low, cruise, and high speed flight regimes. The unified outer loop primary control effectors for the longitudinal and vertical axes (collective pitch, pitch attitude, and propeller pitch) vary depending on flight regime. A weighted pseudoinverse is used to phase either the collective or propeller pitch in/out of a redundant control role. The controllers were evaluated in Penn State's Rotorcraft Flight Simulator retaining the cyclic stick for vertical and lateral axis control along with pedal inceptors for yaw axis control. A throttle inceptor was used in place of the pilot's traditional left hand inceptor for longitudinal axis control. Ultimately, a simple rigid body model of the aircraft was sufficient enough to design a controller with favorable performance and stability characteristics. This unified flight control system promoted a low enough pilot workload so that an untrained pilot (the author) was able to pilot maneuvers of varying complexity with ease. The framework of this unified system is generalized enough to be able to be applied to any rotorcraft with redundant controls. Minimum power propeller thrust shares ranged from 50% - 90% in high speed flight, while lift shares at high speeds tended towards 60% wing and 40% main rotor.

Flight testing a propulsion-controlled aircraft emergency flight control system on an F-15 airplane

NASA Technical Reports Server (NTRS)

Burcham, F. W., Jr.; Burken, John; Maine, Trindel A.

1994-01-01

Flight tests of a propulsion-controlled aircraft (PCA) system on an F-15 airplane have been conducted at the NASA Dryden Flight Research Center. The airplane was flown with all flight control surfaces locked both in the manual throttles-only mode and in an augmented system mode. In the latter mode, pilot thumbwheel commands and aircraft feedback parameters were used to position the throttles. Flight evaluation results showed that the PCA system can be used to land an airplane that has suffered a major flight control system failure safely. The PCA system was used to recover the F-15 airplane from a severe upset condition, descend, and land. Pilots from NASA, U.S. Air Force, U.S. Navy, and McDonnell Douglas Aerospace evaluated the PCA system and were favorably impressed with its capability. Manual throttles-only approaches were unsuccessful. This paper describes the PCA system operation and testing. It also presents flight test results and pilot comments.

Application of Artificial Intelligence Techniques in Unmanned Aerial Vehicle Flight

NASA Technical Reports Server (NTRS)

Bauer, Frank H. (Technical Monitor); Dufrene, Warren R., Jr.

2003-01-01

This paper describes the development of an application of Artificial Intelligence for Unmanned Aerial Vehicle (UAV) control. The project was done as part of the requirements for a class in Artificial Intelligence (AI) at Nova southeastern University and as an adjunct to a project at NASA Goddard Space Flight Center's Wallops Flight Facility for a resilient, robust, and intelligent UAV flight control system. A method is outlined which allows a base level application for applying an AI method, Fuzzy Logic, to aspects of Control Logic for UAV flight. One element of UAV flight, automated altitude hold, has been implemented and preliminary results displayed. A low cost approach was taken using freeware, gnu, software, and demo programs. The focus of this research has been to outline some of the AI techniques used for UAV flight control and discuss some of the tools used to apply AI techniques. The intent is to succeed with the implementation of applying AI techniques to actually control different aspects of the flight of an UAV.

Exploration Medical System Demonstration (EMSD) Project

NASA Technical Reports Server (NTRS)

Chin, Duane

2012-01-01

The Exploration Medical System Demonstration (EMSD) is a project under the Exploration Medical Capability (ExMC) element managed by the Human Research Program (HRP). The vision for the EMSD is to utilize ISS as a test bed to show that several medical technologies needed for an exploration mission and medical informatics tools for managing evidence and decision making can be integrated into a single system and used by the on-orbit crew in an efficient and meaningful manner. Objectives: a) Reduce and even possibly eliminate the time required for on-orbit crew and ground personnel (which include Surgeon, Biomedical Engineer (BME) Flight Controller, and Medical Operations Data Specialist) to access and move medical data from one application to another. b) Demonstrate that the on-orbit crew has the ability to access medical data/information using an intuitive and crew-friendly software solution to assist/aid in the treatment of a medical condition. c) Develop a common data management framework and architecture that can be ubiquitously used to automate repetitive data collection, management, and communications tasks for all crew health and life sciences activities.

NASA researchers in gold control room during an F-15 HiDEC flight

NASA Technical Reports Server (NTRS)

1993-01-01

NASA researchers monitor equipment in the mission control Gold room at the Dryden Flight Research Center, Edwards, California, during a flight of an F-15 Highly Integrated Digital Electronic Control (HIDEC) research aircraft. The system was developed on the F-15 to investigate and demonstrate methods of obtaining optimum aircraft performance. The major elements of HIDEC were a Digital Electronic Flight Control System (DEFCS), a Digital Electronic Engine Control (DEEC), an on-board general purpose computer, and an integrated architecture to allow all components to 'talk to each other.' Unlike standard F-15s, which have a mechanical and analog electronic flight control system, the HIDEC F-15 also had a dual-channel, fail-safe digital flight control system programmed in Pascal. It was linked to the Military Standard 1553B and a H009 data bus which tied all the other electronic systems together.

NASA researchers in gold control room during an F-15 HiDEC flight, John Orme and Gerard Schkolnik

NASA Technical Reports Server (NTRS)

1993-01-01

NASA researchers Gerard Schkolnik (left) and John Orme monitor equipment in the control room at the Dryden Flight Research Center, Edwards, California, during a flight of an F-15 Highly Integrated Digital Electronic Control (HIDEC) research aircraft. The system was developed on the F-15 to investigate and demonstrate methods of obtaining optimum aircraft performance. The major elements of HIDEC were a Digital Electronic Flight Control System (DEFCS), a Digital Electronic Engine Control (DEEC), an on-board general purpose computer, and an integrated architecture to allow all components to 'talk to each other.' Unlike standard F-15s, which have a mechanical and analog electronic flight control system, the HIDEC F-15 also had a dual-channel, fail-safe digital flight control system programmed in Pascal. It was linked to the Military Standard 1553B and a H009 data bus which tied all the other electronic systems together.

Pilot-in-the-Loop Analysis of Propulsive-Only Flight Control Systems

NASA Technical Reports Server (NTRS)

Chou, Hwei-Lan; Biezad, Daniel J.

1996-01-01

Longitudinal control system architectures are presented which directly couple flight stick motions to throttle commands for a multi-engine aircraft. This coupling enables positive attitude control with complete failure of the flight control system. The architectures chosen vary from simple feedback gains to classical lead-lag compensators with and without prefilters. Each architecture is reviewed for its appropriateness for piloted flight. The control systems are then analyzed with pilot-in-the-loop metrics related to bandwidth required for landing. Results indicate that current and proposed bandwidth requirements should be modified for throttles only flight control. Pilot ratings consistently showed better ratings than predicted by analysis. Recommendations are made for more robust design and implementation. The use of Quantitative Feedback Theory for compensator design is discussed. Although simple and effective augmented control can be achieved in a wide variety of failed configurations, a few configuration characteristics are dominant for pilot-in-the-loop control. These characteristics will be tested in a simulator study involving failed flight controls for a multi-engine aircraft.

A pilot rating scale for evaluating failure transients in electronic flight control systems

NASA Technical Reports Server (NTRS)

Hindson, William S.; Schroeder, Jeffery A.; Eshow, Michelle M.

1990-01-01

A pilot rating scale was developed to describe the effects of transients in helicopter flight-control systems on safety-of-flight and on pilot recovery action. The scale was applied to the evaluation of hardovers that could potentially occur in the digital flight-control system being designed for a variable-stability UH-60A research helicopter. Tests were conducted in a large moving-base simulator and in flight. The results of the investigation were combined with existing airworthiness criteria to determine quantitative reliability design goals for the control system.

Psychophysiological investigations of the biomedical problems of manned spaceflight

NASA Technical Reports Server (NTRS)

1993-01-01

The Final Report on psychophysiological investigations of the biomedical problems of manned spaceflight is presented. In the first project, statistical analyses of human autonomic data were performed. The objectives were the following: to establish a relational data base containing human psychophysiological data obtained from Shuttle flight experiments and ground-based research over a 20 year period; to enable multi-user access and retrieval of these data for subsequent analyses and for possible inclusion in the proposed Life Sciences Data Archive; and to enable/conduct statistical analyses across several experiments on large subject populations which can thereby provide definitive answers to questions on human autonomic and behavioral responses and adaptation to environmental stressors on Earth and in space. The second project studied motion sickness. The objectives were: to test/develop hardware and procedures to be incorporated into preflight training of crewmembers of Spacelab-J; and to examine spin-off applications of AFT. The third project studied orthostatic intolerance. The objective was to test the feasibility of applying autogenic-feedback training as a potential treatment for postflight orthostatic intolerance.

Pilot control through the TAFCOS automatic flight control system

NASA Technical Reports Server (NTRS)

Wehrend, W. R., Jr.

1979-01-01

The set of flight control logic used in a recently completed flight test program to evaluate the total automatic flight control system (TAFCOS) with the controller operating in a fully automatic mode, was used to perform an unmanned simulation on an IBM 360 computer in which the TAFCOS concept was extended to provide a multilevel pilot interface. A pilot TAFCOS interface for direct pilot control by use of a velocity-control-wheel-steering mode was defined as well as a means for calling up conventional autopilot modes. It is concluded that the TAFCOS structure is easily adaptable to the addition of a pilot control through a stick-wheel-throttle control similar to conventional airplane controls. Conventional autopilot modes, such as airspeed-hold, altitude-hold, heading-hold, and flight path angle-hold, can also be included.

Preparations for flight research to evaluate actuated forebody strakes on the F-18 high-alpha research vehicle

NASA Technical Reports Server (NTRS)

Murri, Daniel G.; Shah, Gautam H.; Dicarlo, Daniel J.

1994-01-01

As part of the NASA High-Angle-of-Attack Technology Program (HATP), flight tests are currently being conducted with a multi-axis thrust vectoring system applied to the NASA F-18 High Alpha Research Vehicle (HARV). A follow-on series of flight tests with the NASA F-18 HARV will be focusing on the application of actuated forebody strake controls. These controls are designed to provide increased levels of yaw control at high angles of attack where conventional aerodynamic controls become ineffective. The series of flight tests are collectively referred to as the Actuated Nose Strakes for Enhanced Rolling (ANSER) Flight Experiment. The development of actuated forebody strake controls for the F-18 HARV is discussed and a summary of the ground tests conducted in support of the flight experiment is provided. A summary of the preparations for the flight tests is also provided.

Design Specification for a Thrust-Vectoring, Actuated-Nose-Strake Flight Control Law for the High-Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Bacon, Barton J.; Carzoo, Susan W.; Davidson, John B.; Hoffler, Keith D.; Lallman, Frederick J.; Messina, Michael D.; Murphy, Patrick C.; Ostroff, Aaron J.; Proffitt, Melissa S.; Yeager, Jessie C.;

Improving adherence and biomedical markers in hemodialysis patients: the effects of relaxation therapy.

PubMed

Pasyar, Nilofar; Rambod, Masoume; Sharif, Farkhondeh; Rafii, Forough; Pourali-Mohammadi, Nasrin

2015-02-01

This study aimed to assess the effectiveness of Benson's relaxation technique in improving the hemodialysis patients' dietary and fluid adherence and biomedical markers. This randomized controlled trial with a pre-post test design was conducted on 86 hemodialysis patients randomly divided into an intervention (receiving Benson's relaxation technique) and a control group (usual care). The setting of the study was two hemodialysis units affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. The patients listened to the audiotape of Benson's relaxation technique twice a day each time for 20min for 8 weeks. Dietary and fluid adherence and some biomedical markers were measured in both the intervention and the control group at baseline and at the 8th week after the intervention. The results showed significant differences between the two groups regarding blood urea nitrogen and phosphate as dietary adherence and interdialytic weight gain as fluid adherence in the 8th week of the intervention (P<0.05). Also, a significant difference was found between the two groups concerning blood glucose level after the intervention (P<0.05). This study highlighted the importance of Benson's relaxation technique in improvement of adherence and some biomedical markers in hemodialysis patients. Thus, Benson's relaxation therapy could be used as a part of the nursing care practice for hemodialysis patients and those suffering from chronic diseases. Copyright © 2014 Elsevier Ltd. All rights reserved.

Operational viewpoint of the X-29A digital flight control system

NASA Technical Reports Server (NTRS)

Chacon, Vince; Mcbride, David

1988-01-01

In the past few years many flight control systems have been implemented as full-authority, full-time digital systems. The digital design has allowed flight control systems to make use of many enhanced elements that are generally considered too complex to implement in an analog system. Examples of these elements are redundant information exchanged between channels to allow for continued operation after multiple failures and multiple variable gain schedules to optimize control of the aircraft throughout its flight envelope and in all flight modes. The introduction of the digital system for flight control also created the problem of obtaining information from the system in an understandable and useful format. This paper presents how the X-29A was dealt with during its operations at NASA Ames-Dryden Flight Research Facility. A brief description of the X-29A control system, a discussion of the tools developed to aid in daily operations, and the troubleshooting of the aircraft are included.

Flight Operations reunion for the Apollo 11 20th anniversary of the first manned lunar landing

NASA Technical Reports Server (NTRS)

1989-01-01

The following major areas are presented: (1) the Apollo years; (2) official flight control manning list for Apollo 11; (3) original mission control emblem; (4) foundations of flight control; (5) Apollo-11 20th anniversary program and events; (6) Apollo 11 mission operations team certificate; (7) Apollo 11 mission summary (timeline); and (8) Apollo flight control team photographs and biographies.

Control Oriented Modeling and Validation of Aeroservoelastic Systems

NASA Technical Reports Server (NTRS)

Crowder, Marianne; deCallafon, Raymond (Principal Investigator)

2002-01-01

Lightweight aircraft design emphasizes the reduction of structural weight to maximize aircraft efficiency and agility at the cost of increasing the likelihood of structural dynamic instabilities. To ensure flight safety, extensive flight testing and active structural servo control strategies are required to explore and expand the boundary of the flight envelope. Aeroservoelastic (ASE) models can provide online flight monitoring of dynamic instabilities to reduce flight time testing and increase flight safety. The success of ASE models is determined by the ability to take into account varying flight conditions and the possibility to perform flight monitoring under the presence of active structural servo control strategies. In this continued study, these aspects are addressed by developing specific methodologies and algorithms for control relevant robust identification and model validation of aeroservoelastic structures. The closed-loop model robust identification and model validation are based on a fractional model approach where the model uncertainties are characterized in a closed-loop relevant way.

Flight control systems development and flight test experience with the HiMAT research vehicles

NASA Technical Reports Server (NTRS)

Kempel, Robert W.; Earls, Michael R.

1988-01-01

Two highly maneuverable aircraft technology (HiMAT) remotely piloted vehicles were flown a total of 26 flights. These subscale vehicles were of advanced aerodynamic configuration with advanced technology concepts such as composite and metallic structures, digital integrated propulsion control, and ground (primary) and airborne (backup) relaxed static stability, digital fly-by-wire control systems. Extensive systems development, checkout, and flight qualification were required to conduct the flight test program. The design maneuver goal was to achieve a sustained 8-g turn at Mach 0.9 at an altitude of 25,000 feet. This goal was achieved, along with the acquisition of high-quality flight data at subsonic and supersonic Mach numbers. Control systems were modified in a variety of ways using the flight-determined aerodynamic characteristics. The HiMAT program was successfully completed with approximately 11 hours of total flight time.

Intelligent Control Approaches for Aircraft Applications

NASA Technical Reports Server (NTRS)

Gundy-Burlet, Karen; KrishnaKumar, K.; Soloway, Don; Kaneshige, John; Clancy, Daniel (Technical Monitor)

2001-01-01

This paper presents an overview of various intelligent control technologies currently being developed and studied under the Intelligent Flight Control (IFC) program at the NASA Ames Research Center. The main objective of the intelligent flight control program is to develop the next generation of flight controllers for the purpose of automatically compensating for a broad spectrum of damaged or malfunctioning aircraft components and to reduce control law development cost and time. The approaches being examined include: (a) direct adaptive dynamic inverse controller and (b) an adaptive critic-based dynamic inverse controller. These approaches can utilize, but do not require, fault detection and isolation information. Piloted simulation studies are performed to examine if the intelligent flight control techniques adequately: 1) Match flying qualities of modern fly-by-wire flight controllers under nominal conditions; 2) Improve performance under failure conditions when sufficient control authority is available; and 3) Achieve consistent handling qualities across the flight envelope and for different aircraft configurations. Results obtained so far demonstrate the potential for improving handling qualities and significantly increasing survivability rates under various simulated failure conditions.

A Flight Control Approach for Small Reentry Vehicles

NASA Technical Reports Server (NTRS)

Bevacqoa, Tim; Adams, Tony; Zhu. J. Jim; Rao, P. Prabhakara

2004-01-01

Flight control of small crew return vehicles during atmospheric reentry will be an important technology in any human space flight mission undertaken in the future. The control system presented in this paper is applicable to small crew return vehicles in which reaction control system (RCS) thrusters are the only actuators available for attitude control. The control system consists of two modules: (i) the attitude controller using the trajectory linearization control (TLC) technique, and (ii) the reaction control system (RCS) control allocation module using a dynamic table-lookup technique. This paper describes the design and implementation of the TLC attitude control and the dynamic table-lookup RCS control allocation for nonimal flight along with design verification test results.

A biomedical and feminist perspective on women's experiences with weight management.

PubMed

Allan, J D

1994-10-01

Weight concerns and dieting have become so normative for U.S. women that weight is the lens through which experience is viewed. The obsession with weight and dieting among women is considered by feminists to be one result of the oppression by women resulting from questionable weight standards and weight control programs that foster a view of overweight as a sign of addiction and lack of control. Feminist critique is used to deconstruct both the literature related to weight standards and health and the research on weight loss/weight management. Feminist and ethnographic methods are used to describe successful and unsuccessful experiences with weight management of 20 Euro-American women who had participated in a 1985 weight study and agreed to be reinterviewed. Success at weight management was examined from a biomedical perspective using Body Mass Index (BMI) norms and from a feminist perspective using participants' subjective definitions of success. Based upon BMI, only 8 members of the study group were defined as successful, whereas based upon the women's perspectives, 11 members were successful. Participants' definitions of successful weight management were divergent from biomedical definitions and could be categorized into three perspectives: biomedical, reframed normal weight, and holistic. Women who ascribed to the biomedical definition of success embodied the cultural ideal of thinness by adhering to an underweight weight norm. Participants using the reframed normal weight definition of success rejected biomedical weight norms and created their own weight norms. The holistic perspective on success involved the use of a broader, health-focused definition of successful weight management and offers some directions for revising current health promotion care relative to weight.

STS-125 Flight Control Team in BFCR - HST Orbit & Planning Teams

NASA Image and Video Library

2009-05-18

JSC2009-E-120479 (18 May 2009) --- Members of the STS-125 Hubble Space Telescope Planning and Orbit flight control team pose for a group portrait in the blue flight control room in the Mission Control Center at NASA's Johnson Space Center.

STS-125 Flight Control Team in BFCR - HST Planning & Orbit Team

NASA Image and Video Library

2009-05-19

JSC2009-E-120701 (19 May 2009) --- Members of the STS-125 Hubble Space Telescope Planning and Orbit flight control team pose for a group portrait in the blue flight control room in the Mission Control Center at NASA's Johnson Space Center.

Documentation of new mission control center White Flight Control Room (FLCR)

NASA Image and Video Library

1995-06-06

Documentation of the new mission control center White Flight Control Room (FLCR). Excellent overall view of White FLCR with personnel manning console workstations (11221). Fisheye lens perspective from Flight Director station with Brian Austin (11222). Environmental (EECOM) workstation and personnel (11223).

STS-125 Flight Controllers on Console During HST Grapple - Orbit 1. Flight Director: Tony Ceccacci

NASA Image and Video Library

2009-05-13

JSC2009-E-119745 (13 May 2009) --- Flight director Tony Ceccacci (left) and astronaut Dan Burbank, STS-125 spacecraft communicator (CAPCOM), monitor data at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day three activities. The Hubble Space Telescope, grappled by Space Shuttle Atlantis? remote manipulator system (RMS), is visible on one of the big screens.

STS-125 Flight Controllers on Console During HST Grapple - Orbit 1. Flight Director: Tony Ceccacci

NASA Image and Video Library

2009-05-13

JSC2009-E-119746 (13 May 2009) --- Flight director Tony Ceccacci (left) and astronaut Dan Burbank, STS-125 spacecraft communicator (CAPCOM), monitor data at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day three activities. The Hubble Space Telescope, grappled by Space Shuttle Atlantis? remote manipulator system (RMS), is visible on one of the big screens.

Rationale for selection of a flight control system for lift cruise fan V/STOL aircraft

NASA Technical Reports Server (NTRS)

Konsewicz, R. K.

1977-01-01

Various features of the lift cruise fan V/STOL concept are briefly reviewed. The ability to operate from small ships in adverse weather, low visibility, and rough sea conditions is emphasized as is the need for a highly capable, flexible, and reliabile flight control system. A three channel control by wire, digital flight control system is suggested. The requirement for automatic flight control, the advantage of control by wire implementation, the preference for a digital computer, and the need for three channel redundancy are among the factors discussed.

Engineering artificial machines from designable DNA materials for biomedical applications.

PubMed

Qi, Hao; Huang, Guoyou; Han, Yulong; Zhang, Xiaohui; Li, Yuhui; Pingguan-Murphy, Belinda; Lu, Tian Jian; Xu, Feng; Wang, Lin

2015-06-01

Deoxyribonucleic acid (DNA) emerges as building bricks for the fabrication of nanostructure with complete artificial architecture and geometry. The amazing ability of DNA in building two- and three-dimensional structures raises the possibility of developing smart nanomachines with versatile controllability for various applications. Here, we overviewed the recent progresses in engineering DNA machines for specific bioengineering and biomedical applications.

[An integral chip for the multiphase pulse-duration modulation used for voltage changer in biomedical microprocessor systems].

PubMed

Balashov, A M; Selishchev, S V

2004-01-01

An integral chip (IC) was designed for controlling the step-down pulse voltage converter, which is based on the multiphase pulse-duration modulation, for use in biomedical microprocessor systems. The CMOS technology was an optimal basis for the IC designing. An additional feedback circuit diminishes the output voltage dispersion at dynamically changing loads.