CT findings associated with blastic plasmacytoid dendritic cell neoplasm: a case report

PubMed Central

Choi, Jung W; Jeong, Katherine; Sokol, Lubomir

2016-01-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that is frequently misdiagnosed. We present a case of a 53-year-old man diagnosed with blastic plasmacytoid dendritic cell neoplasm with extensive computed tomography (CT) findings and provide an imaging focused review of this uncommon malignancy. PMID:27504192

Rituximab in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer

ClinicalTrials.gov

2017-09-29

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Blastic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Graft Versus Host Disease; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage I Small Lymphocytic Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia; Waldenström Macroglobulinemia

Bortezomib as a new therapeutic approach for blastic plasmacytoid dendritic cell neoplasm.

PubMed

Philippe, Laure; Ceroi, Adam; Bôle-Richard, Elodie; Jenvrin, Alizée; Biichle, Sabeha; Perrin, Sophie; Limat, Samuel; Bonnefoy, Francis; Deconinck, Eric; Saas, Philippe; Garnache-Ottou, Francine; Angelot-Delettre, Fanny

2017-11-01

Blastic plasmacytoid dendritic cell neoplasm is an aggressive hematologic malignancy with a poor prognosis. No consensus regarding optimal treatment modalities is currently available. Targeting the nuclear factor-kappa B pathway is considered a promising approach since blastic plasmacytoid dendritic cell neoplasm has been reported to exhibit constitutive activation of this pathway. Moreover, nuclear factor-kappa B inhibition in blastic plasmacytoid dendritic cell neoplasm cell lines, achieved using either an experimental specific inhibitor JSH23 or the clinical drug bortezomib, interferes in vitro with leukemic cell proliferation and survival. Here we extended these data by showing that primary blastic plasmacytoid dendritic cell neoplasm cells from seven patients were sensitive to bortezomib-induced cell death. We confirmed that bortezomib efficiently inhibits the phosphorylation of the RelA nuclear factor-kappa B subunit in blastic plasmacytoid dendritic cell neoplasm cell lines and primary cells from patients in vitro and in vivo in a mouse model. We then demonstrated that bortezomib can be associated with other drugs used in different chemotherapy regimens to improve its impact on leukemic cell death. Indeed, when primary blastic plasmacytoid dendritic cell neoplasm cells from a patient were grafted into mice, bortezomib treatment significantly increased the animals' survival, and was associated with a significant decrease of circulating leukemic cells and RelA nuclear factor-kappa B subunit expression. Overall, our results provide a rationale for the use of bortezomib in combination with other chemotherapy for the treatment of patients with blastic plasmacytoid dendritic cell neoplasm. Based on our data, a prospective clinical trial combining proteasome inhibitor with classical drugs could be envisaged. Copyright© Ferrata Storti Foundation.

Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant

ClinicalTrials.gov

2017-01-24

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, Breakpoint Cluster Region-abl Translocation (BCR-ABL) Negative; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Gastrointestinal Complications; Juvenile Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Poor Prognosis Metastatic Gestational Trophoblastic Tumor; Previously Treated Childhood Rhabdomyosarcoma; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Neuroblastoma; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Small Lymphocytic Lymphoma; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage II Ovarian Epithelial Cancer; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Ovarian Epithelial Cancer; Stage III Small Lymphocytic Lymphoma; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Breast Cancer; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Ovarian Epithelial Cancer; Stage IV Small Lymphocytic Lymphoma

Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia

ClinicalTrials.gov

2015-10-29

B-cell Adult Acute Lymphoblastic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia

3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia

ClinicalTrials.gov

2014-12-16

Accelerated Phase Chronic Myelogenous Leukemia; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Essential Thrombocythemia; Philadelphia Chromosome Negative Chronic Myelogenous Leukemia; Polycythemia Vera; Primary Myelofibrosis; Relapsing Chronic Myelogenous Leukemia

Myeloid Blastic Transformation of Myeloproliferative Neoplasms – A Review of 112 Cases

PubMed Central

Noor, Syed J; Tan, Wei; Wilding, Gregory E; Ford, Laurie A; Barcos, Maurice; Sait, Sheila N J; Block, AnneMarie W; Thompson, James E; Wang, Eunice S; Wetzler, Meir

2010-01-01

Blastic transformation of myeloproliferative neoplasms (MPN) is still poorly understood. We describe a cohort of 23 Roswell Park Cancer Institute (RPCI) patients and 89 additional cases from the English literature for whom biologic features were described. We initially compared our 23 patients to the 89 cases from the literature. Our population had significantly less patients with prior history of polycythemia vera (PV), shorter time from MPN diagnosis to blastic transformation, <3 prior therapies, more frequent use of hydroxyurea and erythropoietin and less frequent use of alkylating agents. Interestingly, the overall survival of the two cohorts from the time of blastic transformation was similar. We therefore looked at the outcome of the entire cohort (n=112). Patients with prior history of essential thrombocythemia survived longer than patients with prior history of myelofibrosis or PV. Further, patients with <3 prior therapies, those who lacked complex karyotype and those <60 year old at MPN diagnosis had significantly longer survival. Among the PRCI population, 20/23 patients underwent induction treatment with cytarabine and an anthracycline containing regimens; 12 achieved remission and their overall survival was significantly longer than those who did not. Three patients underwent an allogeneic transplantation and their survival was significantly longer than those who did not. Patients with <3 prior therapies, those who lack complex karyotype and those <60 at MPN diagnosis have longer survival following blastic transformation. Finally, allogeneic transplantation represents the only chance for long-term survival in these patients. PMID:20727590

Imatinib Intolerance Is Associated With Blastic Phase Development in Philadelphia Chromosome-Positive Chronic Myeloid Leukemia.

PubMed

Ángeles-Velázquez, Jorge Luis; Hurtado-Monroy, Rafael; Vargas-Viveros, Pablo; Carrillo-Muñoz, Silvia; Candelaria-Hernández, Myrna

2016-08-01

Over the past years, the survival of patients with Philadelphia-positive chronic myeloid leukemia (CML Ph(+)) has increased as a result of therapy with tyrosin kinase inhibitors (TKIs). Intolerance to TKIs has been described in approximately 20% of patients receiving treatment. We studied the incidence of imatinib intolerance in patients with CML Ph(+) and their outcome in our CML reference site, as there is no information about the evolution of patients intolerant to TKIs. A group of 86 patients with CML Ph(+) receiving imatinib monotherapy who abandoned treatment were the basis for this study. We present the trends of their disease evolution. The median of age at diagnosis was 42 years. Within a year, 19 (22%) of 86 patients developed imatinib intolerance, all of them with grade III or IV disease that required imatinib dose reduction or discontinuation. Of these patients, 16 (84%) of 19 developed transformation to blastic phase. The cumulative incidences of blastic phase development were 47% in the nonintolerant group and 84% in the intolerant group. There was a relative risk for those with imatinib intolerance to develop blastic phase of 1.78 (95% confidence interval, 1.28 to 2.42) (P < .05). Most imatinib-intolerant patients develop blastic phase transformation, with a poor survival of 3 to 6 months; no effective rescue treatment is available. Future research should to determine whether the origin of this evolution is really due to the intolerance itself or whether it is due to a more aggressive form of the disease, perhaps related to genetic transformation. Copyright © 2016 Elsevier Inc. All rights reserved.

Monoclonal Antibody Therapy in Treating Patients With Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma, Acute Lymphoblastic Leukemia, or Acute Myeloid Leukemia

ClinicalTrials.gov

2013-06-03

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma

Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer

ClinicalTrials.gov

2015-03-05

Hematopoietic/Lymphoid Cancer; Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Graft Versus Host Disease; Isolated Plasmacytoma of Bone; Juvenile Myelomonocytic Leukemia; Meningeal Chronic Myelogenous Leukemia; Myelodysplastic/Myeloproliferative Disease, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Myelodysplastic Syndromes; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Multiple Myeloma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma

Rituximab and Dexamethasone in Treating Patients With Low-Grade Non-Hodgkin Lymphoma

ClinicalTrials.gov

2017-04-14

Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Marginal Zone Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Marginal Zone Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant

ClinicalTrials.gov

2015-06-03

Hematopoietic/Lymphoid Cancer; Accelerated Phase Chronic Myelogenous Leukemia; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Aplastic Anemia; Atypical Chronic Myeloid Leukemia, BCR-ABL Negative; Blastic Phase Chronic Myelogenous Leukemia; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Cytomegalovirus Infection; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Isolated Plasmacytoma of Bone; Mast Cell Leukemia; Meningeal Chronic Myelogenous Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Polycythemia Vera; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Primary Systemic Amyloidosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Secondary Myelofibrosis; Splenic Marginal Zone Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Multiple Myeloma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Waldenstrom Macroglobulinemia

Blastic transformation in chronic myelogenous leukemia: experience with 50 patients.

PubMed

Marks, S M; McCaffrey, R; Rosenthal, D S; Moloney, W C

1978-01-01

Fifty consecutive patients with blastic chronic myelogenous leukemia were evaluated clinically, morphologically, biochemically, and therapeutically. Forty-five patients had a preceding stable phase (38 Ph'+, 7 Ph'-); five patients presented with de novo Ph+ blast crisis. The most frequent clinical signs of impending blast crisis were weakness, fatigue, increasing splenomegaly, anemia, thrombocytopenia, marrow fibrosis, and a rising neutrophil alkaline phosphatase. Fever (unrelated to infection), skin infiltration, lymphadenopathy, hepatomegaly, thrombocytosis, and basophilia were much less common. The development of aneuploidy occurred in less than one-half of the total group. Myeloblastic morphology at blastic transformation was most frequent with occasional lymphoblastic, promyelocytic, and undifferentiated cases seen. Terminal deoxynucleotidyl transferase was present in one-third of the patients, but had no clear-cut relationship to the morphology. Response to treatment was generally disappointing (two complete and 15 partial remissions in 45 treated patients).

Carfilzomib With or Without Rituximab in the Treatment of Waldenstrom Macroglobulinemia or Marginal Zone Lymphoma

ClinicalTrials.gov

2018-02-05

Marginal Zone Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Waldenstrom Macroglobulinemia; Refractory Marginal Zone Lymphoma; Refractory Waldenstrom Macroglobulinemia; Waldenstrom Macroglobulinemia

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

ClinicalTrials.gov

2017-06-30

Recurrent Chronic Lymphocytic Leukemia; Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Lymphoplasmacytic Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Nodal Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Splenic Marginal Zone Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Refractory Follicular Lymphoma; Refractory Lymphoplasmacytic Lymphoma; Refractory Nodal Marginal Zone Lymphoma; Refractory Small Lymphocytic Lymphoma; Refractory Splenic Marginal Zone Lymphoma; Richter Syndrome; Waldenstrom Macroglobulinemia

Pegfilgrastim and Rituximab in Treating Patients With Untreated, Relapsed, or Refractory Follicular Lymphoma, Small Lymphocytic Lymphoma, or Marginal Zone Lymphoma

ClinicalTrials.gov

2017-09-08

Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma

Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

ClinicalTrials.gov

2018-03-02

Adult Acute Myeloid Leukemia in Remission; Acute Biphenotypic Leukemia; Early Relapse of Acute Myeloid Leukemia; Late Relapse of Acute Myeloid Leukemia; Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Blastic Plasmacytoid Dendritic Cell Neoplasm; Acute Myeloid Leukemia; Adult Acute Lymphoblastic Leukemia; Interleukin-3 Receptor Subunit Alpha Positive; Minimal Residual Disease; Refractory Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia

A Phase I/II Study of Intratumoral Injection of SD-101

ClinicalTrials.gov

2017-09-04

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

Study of BKM120 & Rituximab in Patients With Relapsed or Refractory Indolent B-Cell Lymphoma

ClinicalTrials.gov

2017-09-12

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

[Undifferentiated blastic cell crisis of chronic myelogenous leukemia with myeloblastic tumor in the skin].

PubMed

Kawakami, K; Kiyosaki, M; Amaya, H; Nakamaki, T; Hino, K; Tomoyasu, S

2000-04-01

A 54-year-old female, who had been treated for 4 years in the chronic phase of chronic myelogenous leukemia (CML) was admitted for management of a CML blastic crisis. Blast cells showed strong positive expression of CD7 and HLA-DR, and weakly expressed CD2, CD5 and CD10, as well. The cells were peroxidase negative in peripheral blood and bone marrow. An undifferentiated blastic crisis was diagnosed and she was treated with Interferon-alpha and VP(vincristine 2 mg/week; prednisolone 30 mg/day). A 5-7 mm in diameter tumor in the skin of the anterior right chest appeared one week after VP therapy. The tumor consisted of blasts which were CD13, CD33 and peroxidase positive, unlike the peripheral undifferentiated blasts. This is a rare case of mixed blast crisis with an increase in undifferentiated blasts in peripheral blood and bone marrow, and myeloblastic tumor formation in the skin.

[Monoclonal antibodies ICO-02 to blast cell antigens in patients with chronic myeloleukemia in blast crisis].

PubMed

Baryshnikov, A Iu

1984-01-01

Mice were immunized with blood cells of a patient with chronic granulocytic leukemia, and their cells were subsequently used for the preparation of hybridoma ICO-02. This hybridoma is continuously producing monoclonal antibodies which reacted with cells in 4 out of 13 patients with blastic crisis of chronic granulocytic leukemia and in 6 out of 38 patients with acute lymphoblastic leukemia. Antibodies reacted with blast cells in 2 out of 3 patients with undifferentiated blastic crisis of chronic myelocytic leukemia and in 2 out of 5 patients with lymphoid variant of blastic crisis of chronic granulocytic leukemia. Cells of 6 patients with acute lymphoblastic leukemia which reacted with the monoclonal antibodies had immunological markers of T lymphocytes bone-marrow precursors. Monoclonal antibodies did not react with cells of blood and bone marrow from healthy people and from patients with chronic lymphocytic leukemia, acute myeloblastic leukemia, acute myelomonocytic leukemia, acute monoblastic leukemia and lymphosarcoma.

Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2017-11-07

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

Arsenic Trioxide in Treating Patients With Relapsed or Refractory Lymphoma or Leukemia

ClinicalTrials.gov

2013-01-31

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Prolymphocytic Leukemia; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2015-11-04

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Sca-1(+) mesenchymal stromal cells inhibit splenic marginal zone B lymphocytes commitment through Caspase-3.

PubMed

Chen, Yaozhen; Yang, Jialei; Zhang, Hui-Jie; Fan, Hong; An, Ning; Xin, Jiajia; Li, Na; Xu, Jinmei; Yin, Wen; Wu, Zhongliang; Hu, Xingbin

2016-05-01

Mesenchymal stromal cells (MSCs) have been characterized as an important component of hematopoietic niche, which are capable of modulating the immune system through interaction with a wide range of immune cells. Marginal zone B cells, one main type of mature B lymphocytes, play a central role in eliciting antibody response against pathogens. However, how MSCs and its subpopulations regulate marginal zone B cells commitment is unknown yet. In this study, we assessed the contribution of Sca-1(+) MSCs on marginal zone B cells commitment. Our results showed that Sca-1(+) MSCs inhibit the commitment of marginal zone B lymphocytes. The inhibition was exerted through lowered Caspase-3 expression. Furthermore, we found marginal zone B lymphocytes in spleen of Caspase-3 knockout mice decreased and Caspase-3 knockout Sca-1(+) MSCs accounted for the MZB lymphocytes decrease. In conclusion, our investigation provided clues about Sca-1(+) MSCs regulation on the commitment of marginal zone B cells through Caspase-3 gene. © 2016 International Federation for Cell Biology.

Blastic plasmacytoid dendritic cell neoplasm in an elderly woman.

PubMed

Foong, H B B; Chong, M; Taylor, E M; Carlson, J A; Petrella, T

2013-04-01

Blastic plasmacytoid dendritic cell neoplasm (a.k.a. NK cell lymphoma, CD4+CD56+ haematodermic neoplasm) is a rare aggressive tumour that arises from plasmacytoid dendritic cell precursors. We report the first case from Malaysia of a 79-year-old Chinese woman who presented with purpuric plaques and nodules produced by pleomorphic CD4+, CD56+, CD68+, CD123+ and CD303+, but CD2APmononuclear cell infiltrates. Leukemic dissemination occurred and she succumbed to disease without treatment 4 weeks after diagnosis and 9 months after onset of cutaneous disease.

Blastic natural killer cell leukaemia in a dog--a case report.

PubMed

Bonkobara, Makoto; Saito, Taro; Yamashita, Masahiro; Tamura, Kyoichi; Yagihara, Hiroko; Isotani, Mayu; Sato, Takashi; Washizu, Tsukimi

2007-11-01

A case of canine non-T, non-B lymphoid leukaemia was determined to be of natural killer (NK) cell lineage by detecting specific expression of canine CD56 mRNA by reverse transcriptase polymerase chain reaction analysis. Although NK cells are usually considered to be morphologically large granular lymphocytes, the malignant NK cells in this case were agranular and blast-like, resembling human blastic NK cell leukaemia. The prognosis of human NK cell leukaemia is usually poor. In this case, the dog died 10 days after initial presentation, despite chemotherapy.

Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome.

PubMed

Pajor, L; Matolcsy, A; Vass, J A; Méhes, G; Marton, E; Szabó, F; Iványi, J L

1998-01-01

The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.

A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma.

PubMed

Ozawa, Michael G; Bhaduri, Aparna; Chisholm, Karen M; Baker, Steven A; Ma, Lisa; Zehnder, James L; Luna-Fineman, Sandra; Link, Michael P; Merker, Jason D; Arber, Daniel A; Ohgami, Robert S

2016-10-01

Pediatric-type follicular lymphoma and pediatric marginal zone lymphoma are two of the rarest B-cell lymphomas. These lymphomas occur predominantly in the pediatric population and show features distinct from their more common counterparts in adults: adult-type follicular lymphoma and adult-type nodal marginal zone lymphoma. Here we report a detailed whole-exome deep sequencing analysis of a cohort of pediatric-type follicular lymphomas and pediatric marginal zone lymphomas. This analysis revealed a recurrent somatic variant encoding p.Lys66Arg in the transcription factor interferon regulatory factor 8 (IRF8) in 3 of 6 cases (50%) of pediatric-type follicular lymphoma. This specific point mutation was not detected in pediatric marginal zone lymphoma or in adult-type follicular lymphoma. Additional somatic point mutations in pediatric-type follicular lymphoma were observed in genes involved in transcription, intracellular signaling, and cell proliferation. In pediatric marginal zone lymphoma, no recurrent mutation was identified; however, somatic point mutations were observed in genes involved in cellular adhesion, cytokine regulatory elements, and cellular proliferation. A somatic variant in AMOTL1, a recurrently mutated gene in splenic marginal zone lymphoma, was also identified in a case of pediatric marginal zone lymphoma. The overall non-synonymous mutational burden was low in both pediatric-type follicular lymphoma and pediatric marginal zone lymphoma (4.6 mutations per exome). Altogether, these findings support a distinctive genetic basis for pediatric-type follicular lymphoma and pediatric marginal zone lymphoma when compared with adult subtypes and to one another. Moreover, identification of a recurrent point mutation in IRF8 provides insight into a potential driver mutation in the pathogenesis of pediatric-type follicular lymphoma with implications for novel diagnostic or therapeutic strategies.

A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma

PubMed Central

Ozawa, Michael G; Bhaduri, Aparna; Chisholm, Karen M; Baker, Steven A; Ma, Lisa; Zehnder, James L; Luna-Fineman, Sandra; Link, Michael P; Merker, Jason D; Arber, Daniel A; Ohgami, Robert S

2016-01-01

Pediatric-type follicular lymphoma and pediatric marginal zone lymphoma are two of the rarest B-cell lymphomas. These lymphomas occur predominantly in the pediatric population and show features distinct from their more common counterparts in adults: adult-type follicular lymphoma and adult-type nodal marginal zone lymphoma. Here we report a detailed whole-exome deep sequencing analysis of a cohort of pediatric-type follicular lymphomas and pediatric marginal zone lymphomas. This analysis revealed a recurrent somatic variant encoding p.Lys66Arg in the transcription factor interferon regulatory factor 8 (IRF8) in 3 of 6 cases (50%) of pediatric-type follicular lymphoma. This specific point mutation was not detected in pediatric marginal zone lymphoma or in adult-type follicular lymphoma. Additional somatic point mutations in pediatric-type follicular lymphoma were observed in genes involved in transcription, intracellular signaling, and cell proliferation. In pediatric marginal zone lymphoma, no recurrent mutation was identified; however, somatic point mutations were observed in genes involved in cellular adhesion, cytokine regulatory elements, and cellular proliferation. A somatic variant in AMOTL1, a recurrently mutated gene in splenic marginal zone lymphoma, was also identified in a case of pediatric marginal zone lymphoma. The overall non-synonymous mutational burden was low in both pediatric-type follicular lymphoma and pediatric marginal zone lymphoma (4.6 mutations per exome). Altogether, these findings support a distinctive genetic basis for pediatric-type follicular lymphoma and pediatric marginal zone lymphoma when compared with adult subtypes and to one another. Moreover, identification of a recurrent point mutation in IRF8 provides insight into a potential driver mutation in the pathogenesis of pediatric-type follicular lymphoma with implications for novel diagnostic or therapeutic strategies. PMID:27338637

Concordance between fine-needle aspiration and core biopsies for osseous lesions by lesion imaging appearance and CT attenuation.

PubMed

Li, John; Weissberg, Zoe; Bevilacqua, Thomas A; Yu, Gordon; Weber, Kristy; Sebro, Ronnie

2018-04-01

To compare the concordance between fine-needle aspiration and core biopsies for osseous lesions by lesion imaging appearance and CT attenuation. Retrospective review of 215 FNAs of osseous lesions performed in conjunction with core biopsy at our institution over a 6-year period (2011-2016). FNAs were interpreted independently of core biopsies. We assessed if FNA in conjunction with core biopsy increased diagnostic accuracy compared to core biopsy alone. We also calculated the concordance between FNA and core biopsy by lesion appearance, lesion CT attenuation, lesion histology, lesion location and FNA needle gauge size. Core biopsy alone provided the diagnosis in 207/215 cases (96.3%), however, the FNA provided the diagnosis in the remaining 8/215 cases (3.7%) where the core biopsy was non-diagnostic. There were 154 (71.6%) lytic lesions, 21 (9.8%) blastic lesions, 25 (11.6%) mixed lytic and blastic lesions and 15 (7.0%) lesions that were neither lytic nor blastic. The concordance between FNA and core biopsy for lytic osseous lesions (136/154 cases, 88.3%) was statistically significantly higher than that for blastic osseous lesions (13/21 cases, 61.9%) [P = 4.2 × 10 -3 ; 95% CI (0.02, 0.50)]. The concordance between FNA and core biopsy was higher for low-attenuation- (110/126) than high-attenuation (58/77) lesions (P = 0.028). The concordance between FNA and core biopsy was also higher for metastases (102/119 cases, 85.7%) than non-metastases (78/96, 81.3%) [P = 0.487; 95% CI (- 0.15, 0.065)]. There was no difference in the rate of concordance between FNA and core biopsy by lesion location or FNA needle gauge size (P > 0.05). FNA with core biopsy increases diagnostic rate compared to core biopsy alone or FNA alone. The concordance between FNA and core biopsy is higher for lytic lesions than for blastic lesions; and higher for low-attenuation lesions than for high-attenuation lesions.

Splenic marginal zone lymphoma: comprehensive analysis of gene expression and miRNA profiling.

PubMed

Arribas, Alberto J; Gómez-Abad, Cristina; Sánchez-Beato, Margarita; Martinez, Nerea; Dilisio, Lorena; Casado, Felipe; Cruz, Miguel A; Algara, Patrocinio; Piris, Miguel A; Mollejo, Manuela

2013-07-01

Splenic marginal zone lymphoma is a small B-cell neoplasm whose molecular pathogenesis is still essentially unknown and whose differentiation from other small B-cell lymphomas is hampered by the lack of specific markers. We have analyzed the gene expression and miRNA profiles of 31 splenic marginal zone lymphoma cases. For comparison, 7 spleens with reactive lymphoid hyperplasia, 10 spleens infiltrated by chronic lymphocytic leukemia, 12 spleens with follicular lymphoma, 6 spleens infiltrated by mantle cell lymphoma and 15 lymph nodes infiltrated by nodal marginal zone lymphoma were included. The results were validated by qRT-PCR in an independent series including 77 paraffin-embedded splenic marginal zone lymphomas. The splenic marginal zone lymphoma miRNA signature had deregulated expression of 51 miRNAs. The most highly overexpressed miRNAs were miR-155, miR-21, miR-34a, miR-193b and miR-100, while the most repressed miRNAs were miR-377, miR-27b, miR-145, miR-376a and miR-424. MiRNAs located in 14q32-31 were underexpressed in splenic marginal zone lymphoma compared with reactive lymphoid tissues and other B-cell lymphomas. Finally, the gene expression data were integrated with the miRNA profile to identify functional relationships between genes and deregulated miRNAs. Our study reveals miRNAs that are deregulated in splenic marginal zone lymphoma and identifies new candidate diagnostic molecules for splenic marginal zone lymphoma.

Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma

ClinicalTrials.gov

2014-08-04

B-cell Chronic Lymphocytic Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Fusion Protein Cytokine Therapy After Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma

ClinicalTrials.gov

2015-06-03

Anaplastic Large Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

Bortezomib and Fludarabine With or Without Rituximab in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

ClinicalTrials.gov

2013-09-27

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hematopoietic/Lymphoid Cancer; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

NF-κB deregulation in splenic marginal zone lymphoma.

PubMed

Spina, Valeria; Rossi, Davide

2016-08-01

Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biological basis of splenic marginal zone lymphoma by providing a comprehensive and unbiased view of the genes/pathways that are deregulated in this disease. NF-κB is a family of transcription factors that plays critical roles in development, survival, and activation of B lymphocytes. Consistent with the physiological involvement of NF-κB signalling in proliferation and commitment of mature B-cells to the marginal zone of the spleen, many oncogenic mutations involved in constitutive activation of the NF-κB pathway were recently identified in splenic marginal zone lymphoma. This review describes the progress in understanding the mechanism of NF-κB activation in splenic marginal zone lymphoma, including molecular, epigenetic and post-transcriptional modifications of NF-κB genes and of upstream pathways, and discusses how information gained from these efforts has provided new insights on potential targets of diagnostic, prognostic and therapeutic relevance for splenic marginal zone lymphoma. Copyright © 2016. Published by Elsevier Ltd.

Bryostatin 1 Plus Vincristine in Treating Patients With Progressive or Relapsed Non-Hodgkin's Lymphoma After Bone Marrow or Stem Cell Transplantation

ClinicalTrials.gov

2013-01-09

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

Volume of Lytic Vertebral Body Metastatic Disease Quantified Using Computed Tomography–Based Image Segmentation Predicts Fracture Risk After Spine Stereotactic Body Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thibault, Isabelle; Department of Radiation Oncology, Centre Hospitalier de L'Universite de Québec–Université Laval, Quebec, Quebec; Whyne, Cari M.

Purpose: To determine a threshold of vertebral body (VB) osteolytic or osteoblastic tumor involvement that would predict vertebral compression fracture (VCF) risk after stereotactic body radiation therapy (SBRT), using volumetric image-segmentation software. Methods and Materials: A computational semiautomated skeletal metastasis segmentation process refined in our laboratory was applied to the pretreatment planning CT scan of 100 vertebral segments in 55 patients treated with spine SBRT. Each VB was segmented and the percentage of lytic and/or blastic disease by volume determined. Results: The cumulative incidence of VCF at 3 and 12 months was 14.1% and 17.3%, respectively. The median follow-up was 7.3 months (range,more » 0.6-67.6 months). In all, 56% of segments were determined lytic, 23% blastic, and 21% mixed, according to clinical radiologic determination. Within these 3 clinical cohorts, the segmentation-determined mean percentages of lytic and blastic tumor were 8.9% and 6.0%, 0.2% and 26.9%, and 3.4% and 15.8% by volume, respectively. On the basis of the entire cohort (n=100), a significant association was observed for the osteolytic percentage measures and the occurrence of VCF (P<.001) but not for the osteoblastic measures. The most significant lytic disease threshold was observed at ≥11.6% (odds ratio 37.4, 95% confidence interval 9.4-148.9). On multivariable analysis, ≥11.6% lytic disease (P<.001), baseline VCF (P<.001), and SBRT with ≥20 Gy per fraction (P=.014) were predictive. Conclusions: Pretreatment lytic VB disease volumetric measures, independent of the blastic component, predict for SBRT-induced VCF. Larger-scale trials evaluating our software are planned to validate the results.« less

Rituximab and Interleukin-12 in Treating Patients With B-Cell Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2013-08-23

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

CD22 expression on blastic plasmacytoid dendritic cell neoplasms and reactivity of anti-CD22 antibodies to peripheral blood dendritic cells.

PubMed

Reineks, Edmunds Z; Osei, Ebenezer S; Rosenberg, Arlene; Auletta, Jeffrey; Meyerson, Howard J

2009-07-01

We identified CD22 expression on a blastic plasmacytoid dendritic cell (pDC) neoplasm presenting as a leukemia in a child. CD22 expression, as determined by the antibody s-HCL-1, was also noted on the neoplastic cells from three additional patients with blastic pDC tumors identified at our institution. Subsequently we determined that peripheral blood pDCs react with the s-HCL-1 antibody demonstrating that normal pDCs express CD22. Evaluation of five additional anti-CD22 antibodies indicated that staining of pDCs with these reagents was poor except for s-HCL-1. Therefore, the detection of CD22 on pDCs is best demonstrated with the use of this specific antibody clone. All anti-CD22 antibodies stained conventional DCs. We also evaluated the reactivity of the anti-CD22 antibodies with basophils and noted that the pattern of staining was similar to that seen with pDCs. The studies demonstrate that normal DCs and pDC neoplasms express CD22, and highlight clone specific differences in anti-CD22 antibody reactivity patterns on pDCs and basophils. (c) 2009 Clinical Cytometry Society.

Blastic plasmacytoid dendritic cell neoplasms: clinico-immunohistochemical correlations in a series of 91 patients.

PubMed

Julia, Fanny; Dalle, Stephane; Duru, Gerard; Balme, Brigitte; Vergier, Béatrice; Ortonne, Nicolas; Vignon-Pennamen, Marie D; Costes-Martineau, Valérie; Lamant, Laurence; Dalac, Sophie; Delattre, Claire; Déchelotte, Pierre; Courville, Philippe; Carlotti, Agnès; De Muret, Anne; Fraitag, Sylvie; Levy, Annie; Mitchell, Andrew; Petrella, Tony

2014-05-01

Blastic plasmacytoid dendritic cell neoplasm is a rare clinicopathologic entity, characterized by strong skin tropism and a poor prognosis. The diagnosis is generally made by skin biopsy with appropriate immunohistochemical studies. To identify potential biological prognostic factors for blastic plasmacytoid dendritic cell neoplasm, we performed an extended clinico-immunohistochemical study on a series of 91 well-documented cases collected since 1995 by the French Study Group on Cutaneous Lymphomas. Skin biopsies were analyzed using a panel of 12 immunohistochemical markers (CD4, CD56, CD123, CD303, TCL1, CD68, CD2, CD7, TdT, Ki-67, S100, and MX-1). The results were correlated with survival. The 5 most characteristic markers of this entity (CD4, CD56, CD123, CD303, and TCL1) were expressed simultaneously in only 46% of patients. However, when 4 markers were expressed the diagnosis could still be reliably made without resorting to any additional stains. Expression of TdT and/or S100 correlated with varying degrees of maturation. Statistical survival analyses showed that CD303 expression and high proliferative index (Ki-67) were significantly associated with longer survival.

Pathology of nodal marginal zone lymphomas.

PubMed

Pileri, Stefano; Ponzoni, Maurilio

Nodal marginal zone B cell lymphomas (NMZLs) are a rare group of lymphoid disorders part of the spectrum of marginal zone B-cell lymphomas, which encompass splenic marginal one B-cell lymphoma (SMZL) and extra nodal marginal zone of B-cell lymphoma (EMZL), often of MALT-type. Two clinicopathological forms of NMZL are recognized: adult-type and pediatric-type, respectively. NMZLs show overlapping features with other types of MZ, but distinctive features as well. In this review, we will focus on the salient distinguishing features of NMZL mostly under morphological/immunophenotypical/molecular perspectives in views of the recent acquisitions and forthcoming updated 2016 WHO classification of lymphoid malignancies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Methylation patterns in marginal zone lymphoma.

PubMed

Arribas, Alberto J; Bertoni, Francesco

Promoter DNA methylation is a major regulator of gene expression and transcription. The identification of methylation changes is important for understanding disease pathogenesis, for identifying prognostic markers and can drive novel therapeutic approaches. In this review we summarize the current knowledge regarding DNA methylation in MALT lymphoma, splenic marginal zone lymphoma, nodal marginal zone lymphoma. Despite important differences in the study design for different publications and the existence of a sole large and genome-wide methylation study for splenic marginal zone lymphoma, it is clear that DNA methylation plays an important role in marginal zone lymphomas, in which it contributes to the inactivation of tumor suppressors but also to the expression of genes sustaining tumor cell survival and proliferation. Existing preclinical data provide the rationale to target the methylation machinery in these disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

Iodine I 131 Tositumomab and Fludarabine Phosphate in Treating Older Patients Who Are Undergoing an Autologous or Syngeneic Stem Cell Transplant for Relapsed or Refractory Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2014-08-04

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease

ClinicalTrials.gov

2015-04-14

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

CCI-779 in Treating Patients With Recurrent or Refractory B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

ClinicalTrials.gov

2014-05-07

B-cell Chronic Lymphocytic Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Malignant Neoplasm; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Iodine I 131 Tositumomab, Etoposide and Cyclophosphamide Followed by Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2017-07-21

Anaplastic Large Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics

PubMed Central

Robles, Eloy F.; Mena-Varas, Maria; Barrio, Laura; Merino-Cortes, Sara V.; Balogh, Péter; Du, Ming-Qing; Akasaka, Takashi; Parker, Anton; Roa, Sergio; Panizo, Carlos; Martin-Guerrero, Idoia; Siebert, Reiner; Segura, Victor; Agirre, Xabier; Macri-Pellizeri, Laura; Aldaz, Beatriz; Vilas-Zornoza, Amaia; Zhang, Shaowei; Moody, Sarah; Calasanz, Maria Jose; Tousseyn, Thomas; Broccardo, Cyril; Brousset, Pierre; Campos-Sanchez, Elena; Cobaleda, Cesar; Sanchez-Garcia, Isidro; Fernandez-Luna, Jose Luis; Garcia-Muñoz, Ricardo; Pena, Esther; Bellosillo, Beatriz; Salar, Antonio; Baptista, Maria Joao; Hernandez-Rivas, Jesús Maria; Gonzalez, Marcos; Terol, Maria Jose; Climent, Joan; Ferrandez, Antonio; Sagaert, Xavier; Melnick, Ari M.; Prosper, Felipe; Oscier, David G.; Carrasco, Yolanda R.; Dyer, Martin J. S.; Martinez-Climent, Jose A.

2016-01-01

NKX2 homeobox family proteins have a role in cancer development. Here we show that NKX2-3 is overexpressed in tumour cells from a subset of patients with marginal-zone lymphomas, but not with other B-cell malignancies. While Nkx2-3-deficient mice exhibit the absence of marginal-zone B cells, transgenic mice with expression of NKX2-3 in B cells show marginal-zone expansion that leads to the development of tumours, faithfully recapitulating the principal clinical and biological features of human marginal-zone lymphomas. NKX2-3 induces B-cell receptor signalling by phosphorylating Lyn/Syk kinases, which in turn activate multiple integrins (LFA-1, VLA-4), adhesion molecules (ICAM-1, MadCAM-1) and the chemokine receptor CXCR4. These molecules enhance migration, polarization and homing of B cells to splenic and extranodal tissues, eventually driving malignant transformation through triggering NF-κB and PI3K-AKT pathways. This study implicates oncogenic NKX2-3 in lymphomagenesis, and provides a valid experimental mouse model for studying the biology and therapy of human marginal-zone B-cell lymphomas. PMID:27297662

Normal fates and states of specification of different regions in the axolotl gastrula.

PubMed

Cleine, J H; Slack, J M

1985-04-01

A fate map was constructed for four regions of the early gastrula of Ambystoma mexicanum using orthotopic grafts from donors labelled with FLDx (fluoresceinated-lysinated-dextran). The region around the animal pole gave rise to epidermis only and did not include prospective neural plate. The dorsal marginal zone contributed to cephalic endoderm and to the whole length of the axial mesoderm (notochord and somites), the lateral marginal zone to lateroventral and somitic mesoderm, and the ventral marginal zone to lateroventral mesoderm. It was found that the dorsal marginal zone contributed relatively more to the anterior regions of the mesodermal mantle and the ventral marginal zone more to its posterior parts. The same regions of the gastrula and also vegetal yolky tissue were cultured as explants and labelled with tritiated mannose. Their glycoprotein synthesis pattern was compared to those of the neurula tissues to which they contribute in vivo. Animal pole explants synthesized large amounts of the epidermis-specific marker epimucin. Dorsal marginal zone explants did not synthesize epimucin but did make amounts of S2 and S6 indicative of mesoderm, as well as the notochord-specific markers S2.2 and S3.2. Lateral marginal zone explants showed the same pattern as the dorsal marginal zone including the two notochord-specific markers, although they do not contribute to notochord in vivo. Ventral marginal zone explants were more variable in their behaviour. Yolky tissue from the vegetal hemisphere of the gastrula or the archenteron floor of the neurula synthesized mainly polydisperse material of high molecular weight rather than discrete glycoproteins. The results indicate that at the early gastrula stage states of specification exist which correspond to the three germ layers, ecto-, meso- and endoderm. The ectodermal specification of animal pole explants is quite robust and cannot easily be changed by variation of the culture conditions. However treatment with a concentrated pellet of vegetalizing factor does induce a change to mesodermal specification, which is clearly detectable in the pattern of glycoprotein synthesis. Similar inductive interactions between different regions of the early embryo are thought to occur during normal development.

Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer

ClinicalTrials.gov

2017-12-05

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Polycythemia Vera; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage II Childhood Lymphoblastic Lymphoma; Stage II Childhood Small Noncleaved Cell Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Multiple Myeloma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Childhood Lymphoblastic Lymphoma; Stage III Childhood Small Noncleaved Cell Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Childhood Lymphoblastic Lymphoma; Stage IV Childhood Small Noncleaved Cell Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome; Testicular Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies; Waldenström Macroglobulinemia

MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma

ClinicalTrials.gov

2014-05-22

Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Remote sensing of the marginal ice zone during Marginal Ice Zone Experiment (MIZEX) 83

NASA Technical Reports Server (NTRS)

Shuchman, R. A.; Campbell, W. J.; Burns, B. A.; Ellingsen, E.; Farrelly, B. A.; Gloersen, P.; Grenfell, T. C.; Hollinger, J.; Horn, D.; Johannessen, J. A.

1984-01-01

The remote sensing techniques utilized in the Marginal Ice Zone Experiment (MIZEX) to study the physical characteristics and geophysical processes of the Fram Strait Region of the Greenland Sea are described. The studies, which utilized satellites, aircraft, helicopters, and ship and ground-based remote sensors, focused on the use of microwave remote sensors. Results indicate that remote sensors can provide marginal ice zone characteristics which include ice edge and ice boundary locations, ice types and concentration, ice deformation, ice kinematics, gravity waves and swell (in the water and the ice), location of internal wave fields, location of eddies and current boundaries, surface currents and sea surface winds.

Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review

PubMed Central

van den Brand, Michiel; van Krieken, J. Han J.M.

2013-01-01

The diagnosis of nodal marginal zone lymphoma is one of the remaining problem areas in hematopathology. Because no established positive markers exist for this lymphoma, it is frequently a diagnosis of exclusion, making distinction from other low-grade B-cell lymphomas difficult or even impossible. This systematic review summarizes and discusses the current knowledge on nodal marginal zone lymphoma, including clinical features, epidemiology and etiology, histology, and cytogenetic and molecular features. In particular, recent advances in diagnostics and pathogenesis are discussed. New immunohistochemical markers have become available that could be used as positive markers for nodal marginal zone lymphoma. These markers could be used to ensure more homogeneous study groups in future research. Also, recent gene expression studies and studies describing specific gene mutations have provided clues to the pathogenesis of nodal marginal zone lymphoma, suggesting deregulation of the nuclear factor kappa B pathway. Nevertheless, nodal marginal zone lymphoma remains an enigmatic entity, requiring further study to define its pathogenesis to allow an accurate diagnosis and tailored treatment. However, recent data indicate that it is not related to splenic or extranodal lymphoma, and that it is also not related to lymphoplasmacytic lymphoma. Thus, even though the diagnosis is not always easy, it is clearly a separate entity. PMID:23813646

GTI-2040 in Treating Patients With Relapsed, Refractory, or High-Risk Acute Leukemia, High-Grade Myelodysplastic Syndromes, or Refractory or Blastic Phase Chronic Myelogenous Leukemia

ClinicalTrials.gov

2015-12-03

Acute Undifferentiated Leukemia; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia

Structure across the northeastern margin of Flemish Cap, offshore Newfoundland from Erable multichannel seismic reflection profiles: evidence for a transtensional rifting environment

NASA Astrophysics Data System (ADS)

Welford, J. Kim; Hall, Jeremy; Sibuet, Jean-Claude; Srivastava, Shiri P.

2010-11-01

We present the results from processing and interpreting nine multichannel seismic reflection lines collected during the 1992 Erable experiment over the northeastern margin of Flemish Cap offshore Newfoundland. These lines, combined into five cross-sections, provide increased seismic coverage over this lightly probed section of the margin and reveal tectonically significant along-strike variations in the degree and compartmentalization of crustal thinning. Similar to the southeastern margins of Flemish Cap and the Grand Banks, a transitional zone of exhumed serpentinized mantle is interpreted between thinned continental and oceanic crust. The 25 km wide transitional zone bears similarities to the 120 km wide transitional zone interpreted as exhumed serpentinized mantle on the conjugate Irish Atlantic margin but the significant width difference is suggestive of an asymmetric conjugate pair. A 40-50 km wide zone of inferred strike-slip shearing is interpreted and observed to extend along most of the northeastern margin of Flemish Cap. Individual shear zones (SZs) may represent extensions of SZs and normal faults within the Orphan Basin providing further evidence for the rotation and displacement of Flemish Cap out of Orphan Basin. The asymmetry between the Flemish Cap and Irish conjugate pairs is likely due in large part to the rotation and displacement of Flemish Cap which resulted in the Flemish Cap margin displaying features of both a strike-slip margin and an extensional margin.

The anatomy and histology of the bicipital tunnel of the shoulder.

PubMed

Taylor, Samuel A; Fabricant, Peter D; Bansal, Manjula; Khair, M Michael; McLawhorn, Alexander; DiCarlo, Edward F; Shorey, Mary; O'Brien, Stephen J

2015-04-01

The bicipital tunnel is the extra-articular, fibro-osseous structure that encloses the long head of the biceps tendon. Twelve cadaveric shoulder specimens underwent in situ casting of the bicipital tunnel with methyl methacrylate cement to demonstrate structural competence (n = 6) and en bloc harvest with gross and histologic evaluation (n = 6). The percentage of empty tunnel was calculated histologically by subtracting the proportion of cross-sectional area of the long head of the biceps tendon from that of the bicipital tunnel for each zone. Cement casting demonstrated that the bicipital tunnel was a closed space. Zone 1 extended from the articular margin to the distal margin of the subscapularis tendon. Zone 2 extended from the distal margin of the subscapularis tendon to the proximal margin of the pectoralis major tendon. Zone 3 was the subpectoral region. Zones 1 and 2 were both enclosed by a dense connective tissue sheath and demonstrated the presence of synovium. Zone 3 had significantly greater percentage of empty tunnel than zones 1 and 2 did (P < .01). The bicipital tunnel is a closed space with 3 distinct zones. Zones 1 and 2 have similar features, including the presence of synovium, but differ from zone 3. A significant bottleneck occurs between zone 2 and zone 3, most likely at the proximal margin of the pectoralis major tendon. The bicipital tunnel is a closed space where space-occupying lesions may produce a bicipital tunnel syndrome. Careful consideration should be given to surgical techniques that decompress both zones 1 and 2 of the bicipital tunnel. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Selinexor Plus Combination Chemotherapy in Treating Patients With Advanced B Cell Non-Hodgkin Lymphoma

ClinicalTrials.gov

2018-02-12

Diffuse Large B-Cell Lymphoma; Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Extranodal Marginal Zone Lymphoma; Recurrent Follicular Lymphoma; Recurrent Indolent Adult Non-Hodgkin Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Waldenstrom Macroglobulinemia; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Extranodal Marginal Zone Lymphoma; Refractory Follicular Lymphoma; Refractory Mantle Cell Lymphoma; Stage III Non-Hodgkin Lymphoma; Stage IV Non-Hodgkin Lymphoma; Transformed Recurrent Non-Hodgkin Lymphoma

Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma

ClinicalTrials.gov

2016-08-09

B-cell Adult Acute Lymphoblastic Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Phanerozoic tectonic evolution of the Circum-North Pacific

USGS Publications Warehouse

Nokleberg, Warren J.; Parfenov, Leonid M.; Monger, James W.H.; Norton, Ian O.; Khanchuk, Alexander I.; Stone, David B.; Scotese, Christopher R.; Scholl, David W.; Fujita, Kazuya

2000-01-01

The Phanerozoic tectonic evolution of the Circum-North Pacific is recorded mainly in the orogenic collages of the Circum-North Pacific mountain belts that separate the North Pacific from the eastern part of the North Asian Craton and the western part of the North American Craton. These collages consist of tectonostratigraphic terranes that are composed of fragments of igneous arcs, accretionary-wedge and subduction-zone complexes, passive continental margins, and cratons; they are overlapped by continental-margin-arc and sedimentary-basin assemblages. The geologic history of the terranes and overlap assemblages is highly complex because of postaccretionary dismemberment and translation during strike-slip faulting that occurred subparallel to continental margins.We analyze the complex tectonics of this region by the following steps. (1) We assign tectonic environments for the orogenic collages from regional compilation and synthesis of stratigraphic and faunal data. The types of tectonic environments include cratonal, passive continental margin, metamorphosed continental margin, continental-margin arc, island arc, oceanic crust, seamount, ophiolite, accretionary wedge, subduction zone, turbidite basin, and metamorphic. (2) We make correlations between terranes. (3) We group coeval terranes into a single tectonic origin, for example, a single island arc or subduction zone. (4) We group igneous-arc and subduction- zone terranes, which are interpreted as being tectonically linked, into coeval, curvilinear arc/subduction-zone complexes. (5) We interpret the original positions of terranes, using geologic, faunal, and paleomagnetic data. (6) We construct the paths of tectonic migration. Six processes overlapping in time were responsible for most of the complexities of the collage of terranes and overlap assemblages around the Circum-North Pacific, as follows. (1) During the Late Proterozoic, Late Devonian, and Early Carboniferous, major periods of rifting occurred along the ancestral margins of present-day Northeast Asia and northwestern North America. The rifting resulted in the fragmentation of each continent and the formation of cratonal and passive continental-margin terranes that eventually migrated and accreted to other sites along the evolving margins of the original or adjacent continents. (2) From about the Late Triassic through the mid-Cretaceous, a succession of island arcs and tectonically paired subduction zones formed near the continental margins. (3) From about mainly the mid-Cretaceous through the present, a succession of igneous arcs and tectonically paired subduction zones formed along the continental margins. (4) From about the Jurassic to the present, oblique convergence and rotations caused orogenparallel sinistral and then dextral displacements within the upper-plate margins of cratons that have become Northeast Asia and North America. The oblique convergences and rotations resulted in the fragmentation, displacement, and duplication of formerly more nearly continuous arcs, subduction zones, and passive continental margins. These fragments were subsequently accreted along the expanding continental margins. (5) From the Early Jurassic through Tertiary, movement of the upper continental plates toward subduction zones resulted in strong plate coupling and accretion of the former island arcs and subduction zones to the continental margins. Accretions were accompanied and followed by crustal thickening, anatexis, metamorphism, and uplift. The accretions resulted in substantial growth of the North Asian and North American Continents. (6) During the middle and late Cenozoic, oblique to orthogonal convergence of the Pacifi c plate with present-day Alaska and Northeast Asia resulted in formation of the modern-day ring of volcanoes around the Circum-North Pacific. Oblique convergence between the Pacific plate and Alaska also resulted in major dextral-slip faulting in interior and southern Alaska and along the western p

A new approach to the evolution of the blastic crisis from chronic myelocytic leukemia: dynamic interplay of cellular alterations and a changing microenvironment.

PubMed Central

Grossman, Z

1986-01-01

The mechanisms responsible for the massive hyperplasia and for the blastic crisis in chronic myelocytic leukemia are poorly understood. The most generally accepted hypothesis proposes that this progression is due to the development of genetic instability in the leukemic cells. In particular, the two phases of the disease are believed to reflect different, discrete genetic events. Such events remain undefined as yet, and the causal significance of observed genetic aberrations is not clear. An alternative hypothesis is presented here. It is assumed that the feedback interactions adjust the relative probabilities of maturation and replication of the 'committed' as well as the pluripotent cells, and further that mitotic cells at all stages possess considerable phenotypic adaptability; in particular their self-renewal capacity can vary in response to changes in the cellular composition of the tissue even within a conventionally defined compartment. On this basis, it is shown that chronic leukemia can arise and evolve into the blastic crisis from a progressive decline in a single clonal characteristic--inducibility to maturation. It is shown, with the help of mathematical considerations, how an initial hereditable event in an early hemopoietic cell can cause a disturbance of the tissue which feeds back onto the individual members of the clone, resulting in a cascade of dynamic changes which can lead to blast cell dominance. PMID:3458586

A Phase 2 Study of Concurrent Fludarabine and Rituximab for the Treatment of Marginal Zone Lymphomas

PubMed Central

Brown, Jennifer R; Friedberg, Jonathan W.; Feng, Yang; Scofield, Sarah; Phillips, Kimberly; Cin, Paola Dal; Joyce, Robin; Takvorian, Ronald W; Fisher, David C; Fisher, Richard I; Liesveld, Jane; Marquis, Diana; Neuberg, Donna; Freedman, Arnold S

2009-01-01

SUMMARY The marginal zone lymphomas are a recently defined group of related diseases likely arising from a common cell of origin, the marginal zone B cell. Data on therapy for subtypes other than gastric MALT has been largely limited to retrospective case series. We therefore undertook this prospective phase 2 study of fludarabine and rituximab for the treatment of marginal zone lymphomas. 26 patients were enrolled, 14 with nodal MZL, 8 with MALT lymphomas and 4 with splenic MZL; 81% were receiving initial systemic therapy. Only 58% (95% CI 37–77%) of patients completed the planned six cycles, due to significant hematologic, infectious and allergic toxicity. Four late toxic deaths occurred due to infections (15% (95% CI 4.3–35%), two related to delayed bone marrow aplasia and two related to MDS. Nonetheless, the ORR was 85% (95% CI 65–96%), with 54% CRs. The progression-free survival at 3.1 years of follow-up is 79.5% (95% CI, 63–96%). We conclude that although concurrent fludarabine and rituximab given at this dose and schedule is a highly effective regimen in the treatment of marginal zone lymphomas, the significant hematologic and infectious toxicity observed both during and after therapy is prohibitive in this patient population, emphasizing the need to study marginal zone lymphomas as a separate entity. PMID:19344412

Extranodal Marginal Zone B-cell Lymphoma of the Ocular Adnexa.

PubMed

Guffey Johnson, Jean; Terpak, Lauren A; Margo, Curtis E; Setoodeh, Reza

2016-04-01

Low-grade B-cell lymphomas located around the eye present unique challenges in diagnosis and treatment. Extranodal marginal zone B-cell lymphoma is the most common lymphoma of the ocular adnexa (conjunctiva, orbit, lacrimal gland, and eyelid). A systematic search of the relevant literature was performed. Material pertinent to the diagnosis, prognosis, pathogenesis, and treatment of extranodal marginal zone B-cell lymphoma of the ocular adnexa was identified, reviewed, and analyzed, focusing on management strategies for primary localized disease. The primary cause of extranodal marginal zone B-cell lymphoma of the ocular adnexa remains elusive, although an infectious agent is suspected. Radiotherapy is the most common initial treatment for localized disease. Initial treatment with chemotherapy, immunotherapy, and antibiotics has shown promising results, but the number of series is limited and controlled trials do not exist. Although the long-term outcome of localized extranodal marginal zone B-cell lymphoma of the ocular adnexa is good, optimal treatment remains a goal. The variation in rates of local and systemic relapse among treated stage 1E tumors suggests that critical factors affecting outcomes are not fully understood. Radiotherapy is the standard of care; at this time, the evidence is insufficient to recommend chemotherapy, immunotherapy, or antibiotics for initial treatment of extranodal marginal zone B-cell lymphoma localized to the ocular adnexa. Well-controlled comparative studies are needed.

Splenic marginal zone lymphoma.

PubMed

Piris, Miguel A; Onaindía, Arantza; Mollejo, Manuela

Splenic marginal zone lymphoma (SMZL) is an indolent small B-cell lymphoma involving the spleen and bone marrow characterized by a micronodular tumoral infiltration that replaces the preexisting lymphoid follicles and shows marginal zone differentiation as a distinctive finding. SMZL cases are characterized by prominent splenomegaly and bone marrow and peripheral blood infiltration. Cells in peripheral blood show a villous cytology. Bone marrow and peripheral blood characteristic features usually allow a diagnosis of SMZL to be performed. Mutational spectrum of SMZL identifies specific findings, such as 7q loss and NOTCH2 and KLF2 mutations, both genes related with marginal zone differentiation. There is a striking clinical variability in SMZL cases, dependent of the tumoral load and performance status. Specific molecular markers such as 7q loss, p53 loss/mutation, NOTCH2 and KLF2 mutations have been found to be associated with the clinical variability. Distinction from Monoclonal B-cell lymphocytosis with marginal zone phenotype is still an open issue that requires identification of precise and specific thresholds with clinical meaning. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection

ClinicalTrials.gov

2015-08-18

Adult B Acute Lymphoblastic Leukemia; Chronic Lymphocytic Leukemia; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; HIV Infection; Intraocular Lymphoma; Multicentric Angiofollicular Lymphoid Hyperplasia; Nodal Marginal Zone Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Plasma Cell Myeloma; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma

ClinicalTrials.gov

2018-01-26

Adult Grade III Lymphomatoid Granulomatosis; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

[Diarrhea with malabsorption and exudative enteropathy caused by intestinal myeloid involvement in a patient with myeloproliferative syndrome].

PubMed

Molas, G; Ponsot, P; Solal-Celigny, P; Amar, M; Paolaggi, J A; Potet, F; Henin, D

1992-01-01

A 41-year-old woman with a myelodysplastic syndrome complained of diarrhea with malabsorption and protein-losing enteropathy after splenectomy. No cause was found and various therapeutic regimens were not effective. Pathological examination of biopsies from stomach, small intestine, and large bowel showed infiltrations interpreted as inflammatory on routine technics. Blast cell infiltration was found on electron microscopy. Treatment by citarabine induced normalization of leukocytosis, and diarrhea disappeared. Six months after the onset of illness, she developed acute myeloblastic leukemia and died of infectious pneumonia. Blastic infiltration of the lamina propria could be responsible for the determinism of symptoms, because of the lack of another etiology, the intensity of the blastic infiltration and the effect of cytotoxic therapy, even in the absence of new biopsies.

A Druggable TCF4 and BRD4 dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm

PubMed Central

Ceribelli, Michele; Hou, Zhiying Esther; Kelly, Priscilla N.; Huang, Da Wei; Wright, George; Ganapathi, Karthik; Evbuomwan, Moses O.; Pittaluga, Stefania; Shaffer, Arthur L.; Marcucci, Guido; Forman, Stephen J.; Xiao, Wenming; Guha, Rajarshi; Zhang, Xiaohu; Ferrer, Marc; Chaperot, Laurence; Plumas, Joel; Jaffe, Elaine S.; Thomas, Craig J.; Reizis, Boris; Staudt, Louis M.

2016-01-01

SUMMARY Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasmacytoid dendritic cells (pDCs). Using RNA interference screening, we identified the E-box transcription factor TCF4 as a master regulator of the BPDCN oncogenic program. TCF4 served as a faithful diagnostic marker of BPDCN, and its downregulation caused the loss of the BPDCN-specific gene expression program and apoptosis. High-throughput drug screening revealed that bromodomain and extra-terminal domain inhibitors (BETi’s) induced BPDCN apoptosis, which was attributable to disruption of a BPDCN-specific transcriptional network controlled by TCF4-dependent super-enhancers. BETi’s retarded the growth of BPDCN xenografts, supporting their clinical evaluation in this recalcitrant malignancy. PMID:27846392

Temsirolimus and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia

ClinicalTrials.gov

2013-01-11

Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia; Relapsing Chronic Myelogenous Leukemia

Primary cutaneous marginal zone B-cell lymphoma: clinical and histological aspects.

PubMed

Khaled, A; Sassi, S; Fazaa, B; Ben Hassouna, J; Ben Romdhane, K; Kamoun, M R

2009-02-01

According to the WHO-EORTC classification of cutaneous lymphomas, primary cutaneous marginal zone B-cell lymphoma are now well characterized. We report here a case of primary cutaneous marginal zone B-cell lymphoma in a 51 year-old man in which the diagnosis was made using both histology and immunopathology. The patient had no remarkable medical history, no history of either acute inflammation or insect bite, and presented with a 5 cm solitary asymptomatic erythematous firm, multinodular and infiltrated plaque on the back for 12 months. Histological examination and immunohistochemical study of a cutaneous biopsy provided a differential diagnosis between B cell lymphoma and lymphocytoma cutis. Full body work up revealed no signs of extracutaneous dissemination. The patient underwent surgical excision of the nodule. Histological examination showed a histological and immunophenotyping profile typical of primary cutaneous marginal zone B-cell lymphoma. The lesion was completely excised with clear margins and no recurrence occurred after a 12 month-follow-up period. Primary cutaneous marginal zone B-cell lymphoma are low-grade lymphomas that have an indolent course and a high tendency to recur. They should be differentiated from lymphocytoma cutis and from the other types of cutaneous B cell lymphomas that have a different course and prognosis.

CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

ClinicalTrials.gov

2017-05-25

B-cell Adult Acute Lymphoblastic Leukemia; B-cell Chronic Lymphocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Oblimersen and Gemcitabine in Treating Patients With Advanced Solid Tumor or Lymphoma

ClinicalTrials.gov

2013-01-24

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific

Performance of an airborne imaging 92/183 GHz radiometer during the Bering Sea Marginal Ice Zone Experiment (MIZEX-WEST)

NASA Technical Reports Server (NTRS)

Gagliano, J. A.; Mcsheehy, J. J.; Cavalieri, D. J.

1983-01-01

An airborne imaging 92/183 GHz radiometer was recently flown onboard NASA's Convair 990 research aircraft during the February 1983 Bering Sea Marginal Ice Zone Experiment (MIZEX-WEST). The 92 GHz portion of the radiometer was used to gather ice signature data and to generate real-time millimeter wave images of the marginal ice zone. Dry atmospheric conditions in the Arctic resulted in good surface ice signature data for the 183 GHz double sideband (DSB) channel situated + or - 8.75 GHz away from the water vapor absorption line. The radiometer's beam scanner imaged the marginal ice zone over a + or - 45 degrees swath angle about the aircraft nadir position. The aircraft altitude was 30,000 feet (9.20 km) maximum and 3,000 feet (0.92 km) minimum during the various data runs. Calculations of the minimum detectable target (ice) size for the radiometer as a function of aircraft altitude were performed. In addition, the change in the atmospheric attenuation at 92 GHz under varying weather conditions was incorporated into the target size calculations. A radiometric image of surface ice at 92 GHz in the marginal ice zone is included.

Monoclonal Antibody Therapy and Peripheral Stem Cell Transplant in Treating Patients With Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2013-01-08

Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Waldenström Macroglobulinemia

Flavopiridol in Treating Patients With Relapsed or Refractory Lymphoma or Multiple Myeloma

ClinicalTrials.gov

2016-06-27

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma; Waldenström Macroglobulinemia

Gemcitabine Hydrochloride, Carboplatin, Dexamethasone, and Rituximab in Treating Patients With Previously Treated Lymphoid Malignancies

ClinicalTrials.gov

2017-05-28

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma

ClinicalTrials.gov

2018-04-19

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; Waldenström Macroglobulinemia

Molecular pathogenesis of splenic and nodal marginal zone lymphoma.

PubMed

Spina, Valeria; Rossi, Davide

Genomic studies have improved our understanding of the biological basis of splenic (SMZL) and nodal (NMZL) marginal zone lymphoma by providing a comprehensive and unbiased view of the genes/pathways that are deregulated in these diseases. Consistent with the physiological involvement of NOTCH, NF-κB, B-cell receptor and toll-like receptor signaling in mature B-cells differentiation into the marginal zone B-cells, many oncogenic mutations of genes involved in these pathways have been identified in SMZL and NMZL. Beside genetic lesions, also epigenetic and post-transcriptional modifications contribute to the deregulation of marginal zone B-cell differentiation pathways in SMZL and NMZL. This review describes the progress in understanding the molecular mechanism underlying SMZL and NMZL, including molecular and post-transcriptional modifications, and discusses how information gained from these efforts has provided new insights on potential targets of diagnostic, prognostic and therapeutic relevance in SMZL and NMZL. Copyright © 2016 Elsevier Ltd. All rights reserved.

Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia

ClinicalTrials.gov

2017-05-25

Adult Acute Lymphoblastic Leukemia; Adult Acute Myeloid Leukemia; Adult Burkitt Lymphoma; Adult Diffuse Large Cell Lymphoma; Adult Diffuse Mixed Cell Lymphoma; Adult Diffuse Small Cleaved Cell Lymphoma; Adult Hodgkin Lymphoma; Adult Immunoblastic Large Cell Lymphoma; Adult Lymphoblastic Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Breast Cancer; Chronic Eosinophilic Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Cutaneous T-cell Non-Hodgkin Lymphoma; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3 Follicular Lymphoma; Malignant Testicular Germ Cell Tumor; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Multiple Myeloma; Mycosis Fungoides/Sezary Syndrome; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neutropenia; Nodal Marginal Zone B-cell Lymphoma; Ovarian Epithelial Cancer; Ovarian Germ Cell Tumor; Plasma Cell Neoplasm; Poor Prognosis Metastatic Gestational Trophoblastic Tumor; Primary Myelofibrosis; Prolymphocytic Leukemia; Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma

Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer

ClinicalTrials.gov

2017-04-17

Accelerated Phase Chronic Myelogenous Leukemia; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Aggressive NK-cell Leukemia; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV Infection; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Isolated Plasmacytoma of Bone; Juvenile Myelomonocytic Leukemia; Mast Cell Leukemia; Meningeal Chronic Myelogenous Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Myeloid/NK-cell Acute Leukemia; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Polycythemia Vera; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Central Nervous System Lymphoma; Primary Myelofibrosis; Primary Systemic Amyloidosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage II Childhood Lymphoblastic Lymphoma; Stage II Childhood Small Noncleaved Cell Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Multiple Myeloma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Childhood Lymphoblastic Lymphoma; Stage III Childhood Small Noncleaved Cell Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Hodgkin Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Childhood Lymphoblastic Lymphoma; Stage IV Childhood Small Noncleaved Cell Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Function

ClinicalTrials.gov

2013-01-04

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; Stage II Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

ClinicalTrials.gov

2018-02-07

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

Yttrium Y 90 Ibritumomab Tiuxetan, Fludarabine, Radiation Therapy, and Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

ClinicalTrials.gov

2017-04-17

B-cell Chronic Lymphocytic Leukemia; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Kinematic Reconstruction of the Costa Rican Margin: Evidence for Discontinuities in Deformation Across the Margin

NASA Astrophysics Data System (ADS)

Gose, B.; Bangs, N. L.; McIntosh, K. D.

2016-12-01

Recently acquired 3D seismic reflection data shows that both in-sequence and out-of sequence faults makeup the interior structure of the Costa Rican convergent margin. Recent studies have found evidence for a phase of accretion that led to the formation of a series of thrust-bounded folds that are easily observable within the margin-wedge fabric. Along a primary 2D transect through the center of the 3D survey, faults partition the outer 23km of the margin into 8 fault-bounded segments that can be divided into two characteristic zones, those closest to the trench (S1-S3) and those furthest (S4-S8) separated by a slope break 10 km from the trench (Fig 1). To better understand the observed structure, each segment was characterized as a fault-propagation fold and geometrically modeled using Paradigm's Geosec 2D software. Kinematic flexural slip modules were applied in order to perform bed-length balancing and generate a geologic reconstruction of the margin. Results show the section of the margin spanning from 3-23km from the deformation front has experienced 27.5% shortening, assuming the interpreted horizons were initially flat and continuous. The individual values for percent shortening are not consistent across the margin but distributed into two zones each with progressively increasing strain in the landward direction. Zone 2 (landward) begins with a percent shortening for S8 at 22% and linearly decreases to 2% shortening as you move seaward to S4. The Zone 1-2 boundary is marked by a slope break coinciding with an increase in percent shortening (S3,15%) followed by less shortening seaward (9%, 8%). Shortening and the associated strain is focused at the landward side of the two zones, within S3 and S8. We conclude that the Costa Rican margin has some degree of mechanical partitioning, with a notable discontinuity in strain patterns occurring 10 km from the trench.

Blastic plasmacytoid dendritic cell neoplasm: report of two pediatric cases.

PubMed

Dharmani, Preeti Ashok; Mittal, Neha Manish; Subramanian, P G; Galani, Komal; Badrinath, Yajamanam; Amare, Pratibha; Gujral, Sumeet

2015-01-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of acute leukemia that typically follows a highly aggressive clinical course in adults, whereas experience in children with this disease is very limited. We report cases of two children in whom bone marrow showed infiltration by large atypical monocytoid 'blast-like' cells which on immunophenotyping expressed CD4, CD56, HLA-DR and CD33 while were negative for CD34 other T-cell, B-cell and myeloid markers. The differential diagnoses considered were AML, T/NK-cell leukemia and acute undifferentiated leukemia. Additional markers CD303/BDCA-2 and CD123 which are recently validated plasmacytoid dendritic cell markers were done which helped us clinch the diagnosis of this rare neoplasm. An accurate diagnosis of BPDCN is essential in order to provide prompt treatment. Due to its rarity and only recent recognition as a distinct clinicopathological entity, no standardized therapeutic approach has been established for BPDCN.

Blastic plasmacytoid dendritic cell neoplasm is dependent on BCL-2 and sensitive to venetoclax

PubMed Central

Montero, Joan; Stephansky, Jason; Cai, Tianyu; Griffin, Gabriel K.; Cabal-Hierro, Lucia; Togami, Katsuhiro; Hogdal, Leah J.; Galinsky, Ilene; Morgan, Elizabeth A.; Aster, Jon C.; Davids, Matthew S.; LeBoeuf, Nicole R.; Stone, Richard M.; Konopleva, Marina; Pemmaraju, Naveen; Letai, Anthony; Lane, Andrew A.

2017-01-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the anti-apoptotic protein BCL-2 and were uniformly sensitive to the BCL-2 inhibitor venetoclax, as measured by direct cytotoxicity, apoptosis assays, and dynamic BH3 profiling. Animals bearing BPDCN patient-derived xenografts had disease responses and improved survival after venetoclax treatment in vivo. Finally, we report on two patients with relapsed/refractory BPDCN who received venetoclax off-label and experienced significant disease responses. We propose that venetoclax or other BCL-2 inhibitors undergo expedited clinical evaluation in BPDCN, alone or in combination with other therapies. In addition, these data illustrate an example of precision medicine to predict treatment response using ex vivo functional assessment of primary tumor tissue, without requiring a genetic biomarker. PMID:27986708

Neuroendocrine tumor of cecum in patient treated with imatinib mesylate for blastic phase of chronic myeloid leukemia.

PubMed

Novaković, Sabina; Kovač Peić, Anamarija; Holik, Hrvoje; Coha, Božena

2017-12-01

Imatinib mesylate (IM), a tyrosine kinase inhibitor, is the treatment of choice in patients with chronic myeloid leukemia (CML). It is considered a very safe drug, with mostly mild and reversible side effects. Lately, it has been suggested that adverse events may occur after a long term. We report a case of a 72-year-old woman diagnosed with blastic phase of Philadelphia chromosome positive CML treated with IM for 28 months. The patient presented first with ascites as a side effect of the drug. When the ascites re-occurred, it was caused by neuroendocrine tumor (NET) with peritoneal carcinomatosis. We believe this is the first case of a NET as a secondary malignancy (SM) after IM treatment. SM have been described in patients on IM before. It is unclear whether these tumors are caused by imatinib or found more easily because of close follow-up.

Lenalidomide Maintenance Therapy After High Dose BEAM With or Without Rituximab

ClinicalTrials.gov

2018-01-13

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Waldenström Macroglobulinemia

Style of extensional tectonism during rifting, Red Sea and Gulf of Aden

USGS Publications Warehouse

Bohannon, R.G.

1989-01-01

Geologic and geophysical studies from the Arabian continental margin in the southern Red Sea and LANDSAT analysis of the northern Somalia margin in the Gulf of Aden suggest that the early continental rifts were long narrow features that formed by extension on closely spaced normal faults above moderate- to shallow-dipping detachments with break-away zones defining one rift flank and root zones under the opposing rift flank. The rift flanks presently form the opposing continental margins across each ocean basin. The detachment on the Arabian margin dips gently to the west, with a breakaway zone now eroded above the deeply dissected terrain of the Arabian escarpment. A model is proposed in which upper crustal breakup occurs on large detachment faults that have a distinct polarity. -from Author

Variations of mesoscale and large-scale sea ice morphology in the 1984 Marginal Ice Zone Experiment as observed by microwave remote sensing

NASA Technical Reports Server (NTRS)

Campbell, W. J.; Josberger, E. G.; Gloersen, P.; Johannessen, O. M.; Guest, P. S.

1987-01-01

The data acquired during the summer 1984 Marginal Ice Zone Experiment in the Fram Strait-Greenland Sea marginal ice zone, using airborne active and passive microwave sensors and the Nimbus 7 SMMR, were analyzed to compile a sequential description of the mesoscale and large-scale ice morphology variations during the period of June 6 - July 16, 1984. Throughout the experiment, the long ice edge between northwest Svalbard and central Greenland meandered; eddies were repeatedly formed, moved, and disappeared but the ice edge remained within a 100-km-wide zone. The ice pack behind this alternately diffuse and compact edge underwent rapid and pronounced variations in ice concentration over a 200-km-wide zone. The high-resolution ice concentration distributions obtained in the aircraft images agree well with the low-resolution distributions of SMMR images.

Blastic plasmacytoid dendritic cell neoplasm: update on molecular biology, diagnosis, and therapy.

PubMed

Riaz, Wasif; Zhang, Ling; Horna, Pedro; Sokol, Lubomir

2014-10-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes. A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4(+)CD56(+) hematodermic neoplasm, and blastic natural killer cell lymphoma. Data regarding diagnosis, prognosis, and treatment were analyzed. BPDCN is derived from precursor plasmacytoid dendritic cells. The diagnosis of BPDCN is based on the characteristic cytology and immunophenotype of malignant cells coexpressing CD4, CD56, CD123, blood dendritic cell antigens 2 and 4, and CD2AP markers. Multiple chromosomal abnormalities and gene mutations previously reported in patients with myeloid and selected lymphoid neoplasms were identified in approximately 60% of patients with BPDCN. Prospectively controlled studies to guide treatment decisions are lacking. The overall response rate with aggressive acute lymphoblastic leukemia-type induction regimens was as high as 90%, but the durability of response was short. Median survival rates ranged between 12 and 16 months. Patients with relapsed disease may respond to L-asparaginase-containing regimens. Allogeneic hematopoietic stem cell transplantation, particularly when performed during the first remission, may produce durable remissions in selected adults. BPDCN is a rare aggressive disease that typically affects elderly patients. The most commonly affected nonhematopoietic organ is the skin. Although BPDCN is initially sensitive to conventional chemotherapy regimens, this response is relatively short and long-term prognosis is poor. In the near future, novel targeted therapies may improve outcomes for patients with BPDCN.

Blastic plasmacytoid dendritic cell neoplasm: clinical features in 90 patients.

PubMed

Julia, F; Petrella, T; Beylot-Barry, M; Bagot, M; Lipsker, D; Machet, L; Joly, P; Dereure, O; Wetterwald, M; d'Incan, M; Grange, F; Cornillon, J; Tertian, G; Maubec, E; Saiag, P; Barete, S; Templier, I; Aubin, F; Dalle, S

2013-09-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease characterized by malignant proliferation of a contingent blastic plasmacytoid dendritic cell. This rare entity is recognized mostly by cutaneous spreading, or not having a leukaemic component. The prognosis is very poor. To study a large cohort of 90 patients with BPDCN, to define additional symptoms to form a correct diagnosis earlier, and to manage such patients accordingly. We retrospectively reviewed BPDCN cases registered in the French Study Group on Cutaneous Lymphoma database between November 1995 and January 2012. Ninety patients were studied. Demographic data, clinical presentation, initial staging and outcome were recorded. The group contained 62 male and 28 female patients (sex ratio 2·2). Their ages ranged from 8 to 103 years at the time of diagnosis (mean 67·2 years). Three major different clinical presentations were identified. Sixty-six patients (73%) presented with nodular lesions only, 11 patients (12%) with 'bruise-like' patches and 13 (14%) with disseminated lesions (patches and nodules). Mucosal lesions were seen in five patients (6%). The median survival in patients with BPDCN was 12 months. We here distinguish three different clinical presentations of BPDCN. A nodular pattern is a more common feature than the originally reported 'bruise-like' pattern. Despite the fact that BPDCN may initially appear as a localized skin tumour, aggressive management including allogeneic bone marrow transplantation should be considered immediately, as it is currently the only option associated with long-term survival. © 2013 The Authors BJD © 2013 British Association of Dermatologists.

Analysis of First-Year Twitter Metrics of a Rare Disease Community for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) on Social Media: #BPDCN.

PubMed

Pemmaraju, Naveen; Utengen, Audun; Gupta, Vikas; Thompson, Michael A; Lane, Andrew A

2017-12-01

The use of Twitter, one of the most commonly engaged social media platforms in the world, is increasing among the general public. Notably, this trend has also been observed among those involved in the healthcare field. With its ability to readily connect diverse groups of stakeholders in a given area of interest, Twitter has become a focal point for those involved in increasing awareness and information exchange in orphan disease fields. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy with generally poor long-term outcomes for adult patients and no standard therapeutic guidelines. Coupled with its low incidence rate, the disease has experienced a number of name changes over the past three decades (e.g., blastic NK cell lymphoma, CD4+CD56+ hematodermic tumor), thereby historically resulting in difficulties in its clinico-pathologic diagnosis and treatment approaches. All of these factors have led to a striking gap in terms of accurate information available to patients and the general public. Therefore, there is an urgent need for the development of more venues for the dissemination of information, particularly online, for this rare cancer. In this context, we began the Twitter medical community, #BPDCN, over a year ago, to help fill this information void. Now, completing its first year of existence, we aimed to analyze the metrics of Twitter use in order to better understand and to describe the characteristics and reach in of #BPDCN, and to determine the feasibility of starting and maintaining a disease-specific hashtag community in a particularly rare cancer.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGinnis, J.P.; Karner, G.D.; Driscoll, N.W.

The tectonic and stratigraphic development of the Congo continental margin reflects the timing, magnitude, and distribution of lithospheric extension responsible for its formation. Details of the lithospheric extension process are recorded in the stratigraphic successions preserved along and across the margin. By using the stratal relationships (e.g., onlap, downlap, and truncation) and lithofacies determined from seismic reflection and exploratory well data as input into our basin-modeling strategy, we have developed an integrated approach to determine the relationship between the timing, magnitude, and distribution of lithospheric extension across the margin. Two hinge zones, an eastern and Atlantic hinge formed along themore » Congo margin in response to discrete extensional events occurring from the Berriasian to the Aptian. The eastern hinge zone demarcates the eastern limit of the broadly distributed Berriasian extension. This extension resulted in the formation of deep anoxic, lacustrine systems. In contrast, the Atlantic hinge, located [approximately]90 km west of the eastern hinge, marks the eastern limit of a second phase of extension, which began in the Hauterivian. Consequent footwall uplift and rotation exposed the earlier synrift and prerift stratigraphy to at least wave base causing varying amounts of erosional truncation across the Atlantic hinge zone along much of the Gabon, Congo, and Angola margins. The absence of the Melania Formation across the Congo margin implies that uplift of the Atlantic hinge was relatively minor compared to that across the Angola and Gabon margins. In addition, material eroded from the adjacent and topographically higher hinge zones may in part account for the thick wedge of sediment deposited seaward of the Congo Atlantic hinge. A third phase of extension reactivated both the eastern and Atlantic hinge zones and was responsible for creating the accommodation space for Marnes Noires source rock deposition.« less

Coupling of Waves, Turbulence and Thermodynamics Across the Marginal Ice Zone

DTIC Science & Technology

2015-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Coupling of Waves, Turbulence and Thermodynamics across...developing Thermodynamically Forced Marginal Ice Zone. Submitted to JGR. Heiles,A. S., NPS thesis, Sep. 2014 Schmidt, B. K., NPS thesis March 2012 Shaw

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

ClinicalTrials.gov

2018-06-27

B-Cell Chronic Lymphocytic Leukemia; Monoclonal B-Cell Lymphocytosis; Lymhoma, Small Lymphocytic; Chronic Lymphocytic Leukemia; Lymphoplasmacytic Lymphoma; Waldenstrom Macroglobulinemia; Splenic Marginal Zone Lymphoma

Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer

ClinicalTrials.gov

2017-01-12

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Colon Cancer; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Melanoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Rectal Cancer; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Monoclonal Antibody Therapy Before Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoid Malignancies

ClinicalTrials.gov

2017-10-10

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Bendamustine Hydrochloride, Etoposide, Dexamethasone, and Filgrastim For Peripheral Blood Stem Cell Mobilization in Treating Patients With Refractory or Recurrent Lymphoma or Multiple Myeloma

ClinicalTrials.gov

2017-04-14

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Multiple Myeloma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Methoxyamine and Fludarabine Phosphate in Treating Patients With Relapsed or Refractory Hematologic Malignancies

ClinicalTrials.gov

2015-08-12

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Chronic Lymphocytic Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Biotechnology of Aureobasidium pullulans: A phylogenetic perspective

USDA-ARS?s Scientific Manuscript database

Aureobasidium pullulans is a fungus historically included among the "black yeasts." Although many strains are predominantly yeast-like, the species is actually polymorphic, exhibiting complex forms ranging from blastic conidia and swollen cells to pseudophyphae, hyphae, and chlamydospores. A. pull...

Geodynamic models of the Wilson Cycle: From rifts to mountains to rifts

NASA Astrophysics Data System (ADS)

Buiter, Susanne; Tetreault, Joya; Torsvik, Trond

2015-04-01

The Wilson Cycle theory that oceans close and reopen along the former suture is a fundamental concept in plate tectonics. The theory suggests that subduction initiates at a passive margin, closing the ocean, and that future continental extension localises at the ensuing collision zone. Each stage of the Wilson Cycle will therefore be characterised by inherited structural and thermal heterogeneities. Here we investigate the role of Wilson Cycle inheritance by considering the influence of (1) passive margin structure on continental collision and (2) collision zones on passive margin formation. Passive margins may be preferred locations for subduction initiation because inherited faults and areas of exhumed serpentinized mantle may weaken a margin enough to localise shortening. If subduction initiates at a passive margin, the shape and structure of the passive margins will affect future continental collision. Our review of present-day passive margins along the Atlantic and Indian Oceans reveals that most passive margins are located on former collision zones. Continental break-up occurs on relatively young sutures, such as Morocco-Nova Scotia, and on very old sutures, such as the Greenland-Labrador and East Antarctica-Australia systems. This implies that it is not always post-collisional collapse that initiates the extensional phase of a Wilson Cycle. We highlight the impact of collision zone inheritance on continental extension and rifted margin architecture. We show numerical experiments of one Wilson Cycle of subduction, collision, and extension. Subduction initiates at a tapered passive margin. Closure of a 60 Ma ocean leads to continental collision and slab break-off, followed by some tens of kilometres of slab eduction. Mantle flow above the sinking detached slab enhances deformation in the rift area. The resulting rift exposes not only continental crust, but also subduction-related sediments and oceanic crust remnants. Renewed subduction in the post-collision phase is enabled by lithosphere delamination and slab rollback, leading to back-arc extension in a style similar to the Tyrrhenian Sea.

Application value of different transformation zone types and its genetic relationship with high-risk HPV type in diagnosis and therapy of cervical disease.

PubMed

Chen, Yan; Zhou, Jia-De

2015-01-01

This study aims to discuss the influence of different types of transformation zone (TZ) on positive surgical margin of loop electrosurgical excision procedure (LEEP) and the significance of infection of different genetic high-risk HPV for cervical intraepithelial neoplasm. The clinical data of patients who had CIN2+ and received LEEP during January to December 2013 was investigated. The conditions of positive surgical margin of patients of different transformation zone (type I, II, III) were analyzed. The clinical high-risk types of HPV were divided into three groups, including A5/6, A7 and A9, compared with the pathological conditions of pre-operation and post-operation of the patients in respective group. The results indicated that type III transformation zone is more likely to cause positive cutting margin. For CIN2+ patients, sensitivity and specificity are 0.89% and 79.56% in group A5/6, and negative and positive predicted value (NPV, PPV) are 40% and 5%. The sensitivity, specificity, NPV, PPV in group A7 is 12.5%, 44.08%, 29.49% and 21.21%, respectively. The sensitivity, specificity, NPV, PPV in group A9 is 88.99%, 87.09%, 85.26%, 81.51%, respectively. Transformation zone type was correlated positively with positive cutting margin percentage (r = 0.8732, P < 0.05). Compared with type I, type II and III transformation zone is more likely to cause pathological upgrades. In conclusion, different types of transformation zone and high-risk HPV have clinical significance in causing positive cutting margin of surgery and disease extent.

Investigation of complex slow slip behavior along the Hikurangi subduction zone with earthquake simulator RSQSim

NASA Astrophysics Data System (ADS)

Colella, H.; Ellis, S. M.; Williams, C. A.

2015-12-01

The Hikurangi subduction zone (New Zealand) is one of many subudction zones that exhibit slow slip behavior. Geodetic observations along the Hikurangi subduction zone are unusual in that not only does the subduction zone exhibit periodic slow slip events at "typical" subduction-zone depths of 25-50 km along the southern part of the margin, but also much shallower depths of 8-15 km along the northern part of the margin. Furthermore, there is evidence for interplay between slow slip events at these different depth ranges (between the deep and shallow events) along the central part of the margin, and some of the slow slip behavior is observed along regions of the interface that were previously considered locked, which raises questions about the slip behavior of this region. This study employs the earthquake simulator, RSQSim, to explore variations in the effective normal stress (i.e., stress after the addition of pore fluid pressures) and the frictional instability necessary to generate the complex slow slip events observed along the Hikurangi margin. Preliminary results suggest that to generate slow slip events with similar recurrence intervals to those observed the effective normal stress (MPa) is 3x higher in the south than the north, 6-9MPa versus 2-3MPa, respectively. Results also suggest that, at a minimum, that some overlap along the central margin must exist between the slow slip sections in the north and south to reproduce the types of slip events observed along the Hikurangi subduction zone. To further validate the results from the simulations, Okada solutions for surface displacements will be compared to geodetic solution to more accurately constrain the areas in which slip behavior varies and the cause(s) for the variation(s).

Lenalidomide And Rituximab as Maintenance Therapy in Treating Patients With B-Cell Non-Hodgkin Lymphoma

ClinicalTrials.gov

2015-11-25

Adult Non-Hodgkin Lymphoma; Adult Grade III Lymphomatoid Granulomatosis; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Waldenstrom Macroglobulinemia

Advancing Understanding of Earthquakes by Drilling an Eroding Convergent Margin

NASA Astrophysics Data System (ADS)

von Huene, R.; Vannucchi, P.; Ranero, C. R.

2010-12-01

A program of IODP with great societal relevance is sampling and instrumenting the seismogenic zone. The zone generates great earthquakes that trigger tsunamis, and submarine slides thereby endangering coastal communities containing over sixty percent of the earth’s population. To asses and mitigate this endangerment it is urgent to advance understanding of fault dynamics that allows more timely anticipation of hazardous seismicity. Seismogenesis on accreting and eroding convergent plate boundaries apparently differ because of dissimilar materials along the interplate fault. As the history of instrumentally recorded earthquakes expands the difference becomes clearer. The more homogeneous clay, silt and sand subducted at accreting margins is associated with great earthquakes (M 9) whereas the fragmented upper plate rock that can dominate subducted material along an eroding margin plate interface is associated with many tsunamigenic earthquakes (Bilek, 2010). Few areas have been identified where the seismogenic zone can be reached with scientific drilling. In IODP accreting margins are studied on the NanTroSeize drill transect off Japan where the ultimate drilling of the seismogenic interface may occur by the end of IODP. The eroding Costa Rica margin will be studied in CRISP where a drill program will begin in 2011. The Costa Rican geophysical site survey will be complete with acquisition and processing of 3D seismic data in 2011 but the entire drilling will not be accomplished in IODP. It is appropriate that the accreting margin study be accomplished soon considering the indications of a pending great earthquake that will affect a country that has devoted enormous resources to IODP. However, understanding the erosional end-member is scientifically as important to an understanding of fault mechanics. Transoceanic tsunamis affect the entire Pacific rim where most subduction zones are eroding margins. The Costa Rican subduction zone is less complex operationally and perhaps geologically than the Nankai margin. The developing Central American countries do not have the resources to contribute to IODP but this should not deter acquiring the scientific insights proposed in CRISP considering the broader scientific benefits. Such benefits include the first sampling and instrumentation of an actively eroding plate interface and drilling near or into an earthquake asperity. Drilling an eroding margin should significantly advance understanding of subduction zone fault mechanisms and help improve assessment of future hazardous earthquakes and tsunamis.

Waves and mesoscale features in the marginal ice zone

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Peng, Chih Y.

1993-01-01

Ocean-ice interaction processes in the Marginal Ice Zone (MIZ) by waves and mesoscale features, such as upwelling and eddies, are studied using ERS-1 Synthetic Aperture Radar (SAR) imagery and wave-ice interaction models. Satellite observations of mesoscale features can play a crucial role in ocean-ice interaction study.

Targeted diphtheria toxin to treat BPDCN.

PubMed

FitzGerald, David J

2014-07-17

In this issue of Blood, Frankel et al describe a novel treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) using an engineered version of diphtheria toxin that is targeted to malignant cells via a fusion with interleukin (IL)3 (see panel A).

Wave attenuation in the marginal ice zone during LIMEX

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Peng, Chih Y.; Vachon, Paris W.

1991-01-01

During LIMEX'87 and '89, the CCRS CV-580 aircraft collected SAR (synthetic aperture radar) data over the marginal ice zone off the coast of Newfoundland. Based upon the wavenumber spectra from SAR data, the wave attenuation rate is estimated and compared with a model. The model-data comparisons are reasonably good for the ice conditions during LIMEX (Labrador Ice Margin Experiment). Both model and SAR-derived wave attenuation rates show a roll-over at high wavenumbers.

Metallogenesis and tectonics of the Russian Far East, Alaska, and the Canadian Cordillera

USGS Publications Warehouse

Nokleberg, Warren J.; Bundtzen, Thomas K.; Eremin, Roman A.; Ratkin, Vladimir V.; Dawson, Kenneth M.; Shpikerman, Vladimir I.; Goryachev, Nikolai A.; Byalobzhesky, Stanislav G.; Frolov, Yuri F.; Khanchuk, Alexander I.; Koch, Richard D.; Monger, James W.H.; Pozdeev, Anany I.; Rozenblum, Ilya S.; Rodionov, Sergey M.; Parfenov, Leonid M.; Scotese, Christopher R.; Sidorov, Anatoly A.

2005-01-01

The Proterozoic and Phanerozoic metallogenic and tectonic evolution of the Russian Far East, Alaska, and the Canadian Cordillera is recorded in the cratons, craton margins, and orogenic collages of the Circum-North Pacific mountain belts that separate the North Pacific from the eastern North Asian and western North American Cratons. The collages consist of tectonostratigraphic terranes and contained metallogenic belts, which are composed of fragments of igneous arcs, accretionary-wedge and subduction-zone complexes, passive continental margins, and cratons. The terranes are overlapped by continental-margin-arc and sedimentary-basin assemblages and contained metallogenic belts. The metallogenic and geologic history of terranes, overlap assemblages, cratons, and craton margins has been complicated by postaccretion dismemberment and translation during strike-slip faulting that occurred subparallel to continental margins. Seven processes overlapping in time were responsible for most of metallogenic and geologic complexities of the region (1) In the Early and Middle Proterozoic, marine sedimentary basins developed on major cratons and were the loci for ironstone (Superior Fe) deposits and sediment-hosted Cu deposits that occur along both the North Asia Craton and North American Craton Margin. (2) In the Late Proterozoic, Late Devonian, and Early Carboniferous, major periods of rifting occurred along the ancestral margins of present-day Northeast Asia and northwestern North America. The rifting resulted in fragmentation of each continent, and formation of cratonal and passive continental-margin terranes that eventually migrated and accreted to other sites along the evolving margins of the original or adjacent continents. The rifting also resulted in formation of various massive-sulfide metallogenic belts. (3) From about the late Paleozoic through the mid-Cretaceous, a succession of island arcs and contained igneous-arc-related metallogenic belts and tectonically paired subduction zones formed near continental margins. (4) From about mainly the mid-Cretaceous through the present, a succession of continental-margin igneous arcs (some extending offshore into island arcs) and contained metallogenic belts, and tectonically paired subduction zones formed along the continental margins. (5) From about the Jurassic to the present, oblique convergence and rotations caused orogen-parallel sinistral, and then dextral displacements within the plate margins of the Northeast Asian and North American Cratons. The oblique convergences and rotations resulted in the fragmentation, displacement, and duplication of formerly more continuous arcs, subduction zones, passive continental margins, and contained metallogenic belts. These fragments were subsequently accreted along the margins of the expanding continental margins. (6) From the Early Jurassic through Tertiary, movement of the upper continental plates toward subduction zones resulted in strong plate coupling and accretion of the former island arcs, subduction zones, and contained metallogenic belts to continental margins. In this region, the multiple arc accretions were accompanied and followed by crustal thickening, anatexis, metamorphism, formation of collision-related metallogenic belts, and uplift; this resulted in the substantial growth of the North Asian and North American continents. (7) In the middle and late Cenozoic, oblique to orthogonal convergence of the Pacific Plate with present-day Alaska and Northeast Asia resulted in formation of the present ring of volcanoes and contained metallogenic belts around the Circum-North Pacific. Oblique convergence between the Pacific Plate and Alaska also resulted in major dextral-slip faulting in interior and southern Alaska and along the western part of the Aleutian- Wrangell arc. Associated with dextral-slip faulting was crustal extrusion of terranes from western Alaska into the Bering Sea.

Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant

ClinicalTrials.gov

2017-07-24

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Prolymphocytic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

ClinicalTrials.gov

2015-10-09

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Chronic Lymphocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients With Non-Hodgkin Lymphoma

ClinicalTrials.gov

2016-12-06

Adult Acute Lymphoblastic Leukemia in Remission; Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma

ClinicalTrials.gov

2018-04-10

Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Primary Cutaneous B-Cell Non-Hodgkin Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Non-Hodgkin Lymphoma; Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenstrom Macroglobulinemia

Satellite microwave and in situ observations of the Weddell Sea ice cover and its marginal ice zone

NASA Technical Reports Server (NTRS)

Comiso, J. C.; Sullivan, C. W.

1986-01-01

The radiative and physical characteristics of the Weddell Sea ice cover and its marginal ice zone are analyzed using multichannel satellite passive microwave data and ship and helicopter observations obtained during the 1983 Antarctic Marine Ecosystem Research. Winter and spring brightness temperatures are examined; spatial variability in the brightness temperatures of consolidated ice in winter and spring cyclic increases and decrease in brightness temperatures of consolidated ice with an amplitude of 50 K at 37 GHz and 20 K at 18 GHz are observed. The roles of variations in air temperature and surface characteristics in the variability of spring brightness temperatures are investigated. Ice concentrations are derived using the frequency and polarization techniques, and the data are compared with the helicopter and ship observations. Temporal changes in the ice margin structure and the mass balance of fresh water and of biological features of the marginal ice zone are studied.

Evolution of passive continental margins and initiation of subduction zones

NASA Astrophysics Data System (ADS)

Cloetingh, S. A. P. L.; Wortel, M. J. R.; Vlaar, N. J.

1982-05-01

Although the initiation of subduction is a key element in plate tectonic schemes for evolution of lithospheric plates, the underlying mechanisms are not well understood. Plate rupture is an important aspect of the process of creating a new subduction zone, as stresses of the order of kilobars are required to fracture oceanic lithosphere1. Therefore initiation of subduction could take place preferentially at pre-existing weakness zones or in regions where the lithosphere is prestressed. As such, transform faults2,3 and passive margins4,5 where the lithosphere is downflexed under the influence of sediment loading have been suggested. From a model study of passive margin evolution we found that ageing of passive margins alone does not make them more suitable sites for initiation of subduction. However, extensive sediment loading on young lithosphere might be an effective mechanism for closure of small ocean basins.

Ku band airborne radar altimeter observations of marginal sea ice during the 1984 Marginal Ice Zone Experiment

NASA Technical Reports Server (NTRS)

Drinkwater, Mark R.

1991-01-01

Pulse-limited, airborne radar data taken in June and July 1984 with a 13.8-GHz altimeter over the Fram Strait marginal ice zone are analyzed with the aid of large-format aerial photography, airborne synthetic aperture radar data, and surface observations. Variations in the radar return pulse waveforms are quantified and correlated with ice properties recorded during the Marginal Ice Zone Experiment. Results indicate that the wide-beam altimeter is a flexible instrument, capable of identifying the ice edge with a high degree of accuracy, calculating the ice concentration, and discriminating a number of different ice classes. This suggests that microwave radar altimeters have a sensitivity to sea ice which has not yet been fully exploited. When fused with SSM/I, AVHRR and ERS-1 synthetic aperture radar imagery, future ERS-1 altimeter data are expected to provide some missing pieces to the sea ice geophysics puzzle.

The Cascadia Subduction Zone: two contrasting models of lithospheric structure

USGS Publications Warehouse

Romanyuk, T.V.; Blakely, R.; Mooney, W.D.

1998-01-01

The Pacific margin of North America is one of the most complicated regions in the world in terms of its structure and present day geodynamic regime. The aim of this work is to develop a better understanding of lithospheric structure of the Pacific Northwest, in particular the Cascadia subduction zone of Southwest Canada and Northwest USA. The goal is to compare and contrast the lithospheric density structure along two profiles across the subduction zone and to interpet the differences in terms of active processes. The subduction of the Juan de Fuca plate beneath North America changes markedly along the length of the subduction zone, notably in the angle of subduction, distribution of earthquakes and volcanism, goelogic and seismic structure of the upper plate, and regional horizontal stress. To investigate these characteristics, we conducted detailed density modeling of the crust and mantle along two transects across the Cascadia subduction zone. One crosses Vancouver Island and the Canadian margin, the other crosses the margin of central Oregon.

CD56+ blastic transformation of chronic myeloid leukemia involving the skin.

PubMed

Kaddu, S; Beham-Schmid, C; Zenahlik, P; Kerl, H; Cerroni, L

1999-11-01

We report on two patients with chronic myeloid leukemia (CML) who presented blastic transformation involving the skin, with leukemic infiltrates showing unusual morphologic and immunohistologic characteristics. Both patients were elderly men with a 36-month and a 40-month history of CML, respectively. They presented with disseminated, reddish to violaceous papules and plaques (case 1), and with localized reddish nodules on the left temporal area (case 2). Concurrent features of blastic transformation in the bone marrow were observed in one patient (case 1). Histopathologic examination of skin lesions revealed similar features in both cases. There was a moderate to dense dermal infiltrate composed mainly of medium-sized atypical mononuclear myeloid precursor cells with only few relatively well-differentiated cells of the granulocytic series. Histochemical staining for naphthol-ASD-chloroacetate esterase revealed strong positivity (>50% of neoplastic cells) in case 2 and only scattered positivity (< 10% of neoplastic cells) in case 1. Immunohistologic analysis performed on paraffin-embedded sections showed in both cases variable reactivity of neoplastic cells for leucocyte common antigen (CD45), lysozyme, myeloperoxidase, CD11c, CD15, CD43, CD66, CD68, HLA-DR, and the neural cell adhesion molecule (NCAM) CD56. A negative reaction was observed for CD3, CD34, and TdT. The immunohistologic findings were remarkably similar to those reported for acute myeloid leukemia (AML) with monocytic differentiation (French-American-British [FAB] classification, subtype M4). Examination of blasts from the bone marrow performed in one patient (case 1) revealed a similar phenotype also with CD56 expression. In conclusion, our observations show that specific cutaneous infiltrates in CML may show morphologic and immunohistochemical characteristics similar to those observed in AML with monocytic differentiation. Moreover, specific cutaneous manifestations of CML may express CD56.

Emerging role of infectious etiologies in the pathogenesis of marginal zone B-cell lymphomas.

PubMed

Zucca, Emanuele; Bertoni, Francesco; Vannata, Barbara; Cavalli, Franco

2014-10-15

Extranodal marginal zone B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT) arise from lymphoid populations that are induced by chronic inflammation in extranodal sites. The most frequently affected organ is the stomach, where MALT lymphoma is incontrovertibly associated with a chronic gastritis induced by a microbial pathogen, Helicobacter pylori. Gastric MALT lymphoma therefore represents a paradigm for evaluating inflammation-associated lymphomagenesis, which may lead to a deeper understanding of a possible etiologic association between other microorganisms and nongastric marginal zone lymphomas. Besides infectious etiology, chronic inflammation caused by autoimmune diseases, such as Sjögren syndrome or Hashimoto thyroiditis, can also carry a significant risk factor for the development of marginal zone lymphoma. In addition to the continuous antigenic drive, additional oncogenic events play a relevant role in lymphoma growth and progression to the point at which the lymphoproliferative process may eventually become independent of antigenic stimulation. Recent studies on MALT lymphomas have in fact demonstrated genetic alterations affecting the NF-κB) pathway, a major signaling pathway involved in many cancers. This review aims to present marginal zone lymphoma as an example of the close pathogenetic link between chronic inflammation and tumor development, with particular attention to the role of infectious agents and the integration of these observations into everyday clinical practice. See all articles in this CCR Focus section, "Paradigm Shifts in Lymphoma." ©2014 American Association for Cancer Research.

MS-275 and Isotretinoin in Treating Patients With Metastatic or Advanced Solid Tumors or Lymphomas

ClinicalTrials.gov

2013-01-23

Adult Grade III Lymphomatoid Granulomatosis; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

Large and giant hydrocarbon accumulations in the transitional continent-ocean zone

NASA Astrophysics Data System (ADS)

Khain, V. E.; Polyakova, I. D.

2008-05-01

The petroleum resource potential is considered for the Atlantic, West Pacific, and East Pacific types of deepwater continental margins. The most considerable energy resources are concentrated at the Atlantic-type passive margins in the zone transitional to the ocean. The less studied continental slope of backarc seas of the generally active margins of the West Pacific type is currently not so rich in discoveries as the Atlantic-type margin, but is not devoid of certain expectations. In some of their parameters, the margins bounded by continental slopes may be regarded as analogs of classical passive margins. At the margins of the East Pacific type, the petroleum potential is solely confined to transform segments. In the shelf-continental-slope basins of the rift and pull-apart nature, petroleum fields occur largely in the upper fan complex, and to a lesser extent in the lower graben (rift) complex. In light of world experience, the shelf-continental-slope basins of the Arctic and Pacific margins of Russia are evaluated as highly promising.

Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas

ClinicalTrials.gov

2017-09-28

Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Progressive Hairy Cell Leukemia, Initial Treatment; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Small Lymphocytic Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia

On the initiation of subduction

NASA Technical Reports Server (NTRS)

Mueller, Steve; Phillips, Roger J.

1991-01-01

Estimates of shear resistance associated with lithospheric thrusting and convergence represent lower bounds on the force necessary to promote trench formation. Three environments proposed as preferential sites of incipient subduction are investigated: passive continental margins, transform faults/fracture zones, and extinct ridges. None of these are predicted to convert into subduction zones simply by the accumulation of local gravitational stresses. Subduction cannot initiate through the foundering of dense oceanic lithosphere immediately adjacent to passive continental margins. The attempted subduction of buoyant material at a mature trench can result in large compressional forces in both subducting and overriding plates. This is the only tectonic force sufficient to trigger the nucleation of a new subduction zone. The ubiquitous distribution of transform faults and fracture zones, combined with the common proximity of these features to mature subduction complexes, suggests that they may represent the most likely sites of trench formation if they are even marginally weaker than normal oceanic lithosphere.

On the initiation of subduction zones

NASA Astrophysics Data System (ADS)

Cloetingh, Sierd; Wortel, Rinus; Vlaar, N. J.

1989-03-01

Analysis of the relation between intraplate stress fields and lithospheric rheology leads to greater insight into the role that initiation of subduction plays in the tectonic evolution of the lithosphere. Numerical model studies show that if after a short evolution of a passive margin (time span a few tens of million years) subduction has not yet started, continued aging of the passive margin alone does not result in conditions more favorable for transformation into an active margin. Although much geological evidence is available in supporting the key role small ocean basins play in orogeny and ophiolite emplacement, evolutionary frameworks of the Wilson cycle usually are cast in terms of opening and closing of wide ocean basins. We propose a more limited role for large oceans in the Wilson cycle concept. In general, initiation of subduction at passive margins requires the action of external plate-tectonic forces, which will be most effective for young passive margins prestressed by thick sedimentary loads. It is not clear how major subduction zones (such as those presently ringing the Pacific Basin) form but it is unlikely they form merely by aging of oceanic lithosphere. Conditions likely to exist in very young oceanic regions are quite favorable for the development of subduction zones, which might explain the lack of preservation of back-arc basins and marginal seas. Plate reorganizations probably occur predominantly by the formation of new spreading ridges, because stress relaxation in the lithosphere takes place much more efficiently through this process than through the formation of new subduction zones.

Successful treatment with biweekly CHOP for bone marrow relapse of blastic plasmacytoid dendritic cell neoplasm.

PubMed

Ono, Keiko; Ise, Mikiko; Ikebe, Dai; Sato, Akiyasu; Wang, Xiaofei; Sugawara, Takeaki; Tsujimura, Hideki; Itami, Makiko; Kumagai, Kyoya

2017-01-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy derived from precursors of plasmacytoid dendritic cells. The majority of patients initially respond to multi-agent chemotherapy, though most relapse within a year and the prognosis is very poor. We report a 67-year-old man with erythema on the right chest and a nasopharyngeal mass. Histological examination revealed a mass of tumor cells expressing CD4, CD56, and CD123, but neither CD3 nor CD20. He was diagnosed with BPDCN. Bone marrow involvement was not seen at diagnosis. He achieved complete remission (CR) with CHOP-like chemotherapy. After 1 year, he relapsed with a cutaneous tumor on the head, a nasopharyngeal tumor, and massive bone marrow involvement. Relapsed BPDCN is generally resistant to chemotherapy and the prognosis is dismal. However, he was successfully treated with biweekly CHOP therapy and achieved a second CR lasting 16 months.

Meaning-Making and Motivation in Urban Zones of Marginalization: Mapping the Ecocultural Context of Educational Goals

ERIC Educational Resources Information Center

Eksner, H. Julia

2015-01-01

This article explores how achievement motivation is framed by the larger context of the devaluation of educational capital that is currently underway in urban centers in Europe. The article elucidates the shared cultural meaning working-class German Turkish youths living in urban marginalized zones in Berlin, Germany create about the decreasing…

Remote sensing of the Fram Strait marginal ice zone

USGS Publications Warehouse

Shuchman, R.A.; Burns, B.A.; Johannessen, O.M.; Josberger, E.G.; Campbell, W.J.; Manley, T.O.; Lannelongue, N.

1987-01-01

Sequential remote sensing images of the Fram Strait marginal ice zone played a key role in elucidating the complex interactions of the atmosphere, ocean, and sea ice. Analysis of a subset of these images covering a 1-week period provided quantitative data on the mesoscale ice morphology, including ice edge positions, ice concentrations, floe size distribution, and ice kinematics. The analysis showed that, under light to moderate wind conditions, the morphology of the marginal ice zone reflects the underlying ocean circulation. High-resolution radar observations showed the location and size of ocean eddies near the ice edge. Ice kinematics from sequential radar images revealed an ocean eddy beneath the interior pack ice that was verified by in situ oceanographic measurements.

Transformation of marginal zone lymphoma (and association with other lymphomas).

PubMed

Casulo, Carla; Friedberg, Jonathan

Marginal zone lymphomas (MZL) are a diverse group of indolent lymphoproliferative disorders that comprise three subtypes: nodal, splenic and mucosal associated marginal zone lymphomas (MALT). Histologic transformation (HT) to an aggressive lymphoma is a rare event that can occur in any subtype, and at lower frequency compared to other indolent non Hodgkin lymphomas (NHL) like follicular lymphoma. There are few data directly associated with risk and prognosis of transformation in MZL. However, recent advances in the understanding of molecular and genetic features of MALT have contributed to an evolving appreciation of HT in this disease. Optimal treatment of HT of MZL remains unknown. Much of the approach to managing transformed MZL is extrapolated from other indolent NHLs. Copyright © 2016 Elsevier Ltd. All rights reserved.

Mineral, Virginia earthquake illustrates seismicity of a passive-aggressive margin

NASA Astrophysics Data System (ADS)

Stein, S. A.; Pazzaglia, F. J.; Meltzer, A.; Berti, C.; Wolin, E.; Kafka, A. L.

2011-12-01

The August 2011 M5.8 Virginia earthquake illustrated again that "passive" continental margins, at which the continent and neighboring seafloor are part of the same plate, are often seismically active. This phenomenon occurs worldwide, with the east coast of North America a prime example. Examples from North to South include the 1933 M 7.3 Baffin Bay, 1929 M 7.2 Grand Banks of Newfoundland, 1755 M 6 Cape Ann, Massachusetts, and 1886 M 7 Charleston earthquakes. The mechanics of these earthquakes remains unclear. Their overall alignment along the margin suggests that they reflect reactivation of generally margin-parallel faults remaining from continental convergence and later rifting by the modern stress field. This view accords with the occurrence of the Virginia earthquake by reverse faulting on a margin-parallel NE-SW striking fault. However, it occurred on the northern edge of the central Virginia seismic zone, a seismic trend normal to the fault plane, margin, and associated structures, that has no clear geologic expression. Hence it is unclear why this and similar seismic zones have the geometry they do. Although it is tempting to correlate these zones with extensions of Atlantic fracture zones, this correlation has little explanatory power given the large number of such zones. It is similarly unclear whether these zones and the intervening seismic gaps reflect areas that are relatively more active over time, or are instead the present loci of activity that migrates. It is also possible that the presently-active zones reflect long-lived aftershocks of large prehistoric earthquakes. The forces driving the seismicity are also unclear. In general, seismic moment release decreases southward along the margin, consistent with the variation in vertical motion rates observed by GPS, suggesting that glacial-isostatic adjustment (GIA) provides some of the stresses involved. However, in the mid-Atlantic region - south of the area of significant GIA - deformed stratigraphic and geomorphic markers, localized high-relief topography, and rapid river incision show uplift of the Piedmont and Appalachians relative to the Coastal Plain for the past 10 Ma, suggesting that the seismicity reflects active and long-term deformation. These challenging questions are natural candidates for further study using new seismological and GPS data from the EarthScope program, together with geological and modeling studies. The dense deployment of seismometers in the wake of the Mineral VA earthquake and the arrival of EarthScope on the eastern seaboard in 2012 and 2013 can provide the required observations at multiple scales to better understand the mechanics of and forces driving east coast seismicity. Here we begin this study by comparing the aftershock sequence of the Mineral VA earthquake to previously recorded events in the Reading Lancaster Seismic Zone and the Central Virginia Seismic Zone.

Correlation and zonation of miocene strata along the atlantic margin of North America using diatoms and silicoflagellates

USGS Publications Warehouse

Abbott, W.H.

1978-01-01

Six Atlantic Miocene siliceous microfossil zones are proposed based on onshore and offshore samples from the United States Atlantic Margin. Diatoms and silicoflagellates are used to establish the zones. These zones are from oldest to youngest: 1. Zone I Actinoptychus heliopelta Concurrent Range Zone - Early Miocene 2. Zone II Delphineis ovata Partial Range Zone - late Early to early Middle Miocene 3. Zone III Delphineis ovata/Delphineis penelliptica Concurrent Range Zone - early Middle Miocene 4. Zone IV Delphineis penelliptica Partial Range Zone - Middle Miocene 5. Zone V Delphineis penelliptica/Coscinodiscus plicatus Concurrent Range Zone - Middle Miocene 6. Zone VI Coscinodiscus plicatus Partial Range Zone - Middle Miocene. The six zones are easily traced along the Southern and Middle Atlantic Seaboard, but the older three are found for the most part between Cape Hatteras and New Jersey. There is some suggestion of sea-level change during Zone IV. Using rare planktonic diatoms that are index species from other regions and the zonal markers established in this study, correlation can be made with the Standard Foraminiferal Zones, the North Pacific Diatom Zones and with DSDP core 391A in the Blake-Bahama Basin. ?? 1978.

Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity.

PubMed

Ambrosio, Maria Raffaella; De Falco, Giulia; Rocca, Bruno Jim; Barone, Aurora; Amato, Teresa; Bellan, Cristiana; Lazzi, Stefano; Leoncini, Lorenzo

2015-10-01

The concept of unidirectional differentiation of the haematopoietic stem cell has been challenged after recent findings that human B cell progenitors and even mature B cells can be reprogrammed into histiocytic/dendritic cells by altering expression of lineage-associated transcription factors. The conversion of mature B cell lymphomas to Langerhans cell neoplasms is not well documented. Three previous reports have described clonally related follicular lymphoma and Langerhans cell tumours, whereas no case has been published of clonally related marginal zone lymphoma and Langerhans cell sarcoma. We describe the case of a 77-year-old patient who developed a Langerhans cell sarcoma and 6 years later a nodal marginal zone lymphoma. Mutation status examination showed 100 % gene identity to the germline sequence, suggesting direct trans-differentiation or dedifferentiation of the nodal marginal zone lymphoma to the Langerhans cell sarcoma rather than a common progenitor. We found inactivation of paired box 5 (PAX-5) in the lymphoma cells by methylation, along with duplication of part of the long arm of chromosomes 16 and 17 in the sarcoma cells. The absence of PAX-5 could have triggered B cells to differentiate into macrophages and dendritic cells. On the other hand, chromosomal imbalances might have activated genes involved in myeloid lineage maturation, transcription activation and oncogenesis. We hypothesize that this occurred because of previous therapies for nodal marginal zone lymphoma. Better understanding of this phenomenon may help in unravelling the molecular interplay between transcription factors during haematopoietic lineage commitment and may expand the spectrum of clonally related mature B cell neoplasms and Langerhans cell tumours.

The Afar-Red Sea-Gulf of Aden volcanic margins system : early syn-rift segmentation and tectono-magmatic evolution

NASA Astrophysics Data System (ADS)

Stab, Martin; Leroy, Sylvie; Bellahsen, Nicolas; Pik, Raphaël; Ayalew, Dereje; Yirgu, Gezahegn; Khanbari, Khaled

2017-04-01

The Afro-Arabian rift system is characterized by complex interactions between magmatism and rifting, leading to long-term segmentation of the associated continental margins. However, past studies focused on specific rift segments and no attempt has yet been made to reconcile them into a single comprehensive geodynamic model. To address this, we present interpretations of seismic profiles offshore the Eritrea-Yemeni margins in the southern Red Sea and the Yemeni margin in the Gulf of Aden and reassess the regional geodynamic evolution including the new tectonic evolution of the Central Afar Magmatic margin. We point out the role of two major transform zones in structuring the volcanism and faulting of the Red Sea-Afar-Aden margins. We show that those transform zones not only control the present-day rift organization, but were also active since the onset of rifting in Oligocene times. Early syn-rift transform zones control the emplacement and the development of seaward-dipping-reflector wedges immediately after the Continental Flood basalts (30 Ma), and are closely associated with mantle plume melts in the course of the segment extension. The margins segmentation thus appears to reflect the underlying mantle dynamics and thermal anomaly, which have directly influenced the style of rifting (wide vs. narrow rift), in controlling the development of preferential lithospheric thinning and massive transfer of magmas in the crust.

Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma

ClinicalTrials.gov

2017-10-23

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage II Multiple Myeloma; Stage III Multiple Myeloma; Testicular Lymphoma; Waldenström Macroglobulinemia

Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma

ClinicalTrials.gov

2017-12-05

B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; B-cell Chronic Lymphocytic Leukemia; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies

ClinicalTrials.gov

2016-11-17

Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Relapsing Chronic Myelogenous Leukemia; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

A comparison of radiation budgets in the Fram Strait marginal ice zone

NASA Technical Reports Server (NTRS)

Francis, Jennifer A.; Katsaros, Kristina B.; Ackerman, Thomas P.; Lind, Richard J.; Davidson, Kenneth L.

1991-01-01

Results are presented from calculations of radiation budgets for the sea-ice and the open-water regimes in the marginal ice zone (MIZ) of the Fram Strait, from measurements of surface irradiances and meteorological conditions made during the 1984 Marginal Ice Zone Experiment. Simultaneous measurements on either side of the ice edge allowed a comparison of the open-water and the sea-ice environments. The results show significant differences between the radiation budgets of the two regimes in the MIZ. The open water absorbed twice as much radiation as did the ice, and the mean cooling rate of the atmosphere over water was approximately 15 percent larger than that over ice. Calculated fluxes and atmospheric cooling rates were found to compare well with available literature data.

Bortezomib and Filgrastim in Promoting Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple Myeloma Undergoing Stem Cell Transplant

ClinicalTrials.gov

2017-05-23

Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Small Lymphocytic Lymphoma; Stage II Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia

Geophysical evidence for a transform margin in Northwestern Algeria: possible vestige of a Subduction-Transform Edge Propagator

NASA Astrophysics Data System (ADS)

Badji, R.; Charvis, P.; Bracene, R.; Galve, A.; Badsi, M.; Ribodetti, A.; Benaissa, Z.; Klingelhoefer, F.; Medaouri, M.; Beslier, M.

2013-12-01

This work is part of the Algerian-French SPIRAL program (Sismique Profonde et Investigation Régionale du Nord de l'Algérie) which provides unprecedented images of the deep structure of the western Algerian Margin based on several wide-angle and multichannel seismic data shot across the Algerian Margin. One of the different hypotheses for the opening of the western Mediterranean Sea, we are testing is that the western part of the Algerian margin was possibly part of the southern edge of the Alboran continental block during its westward migration related to the rollback of the Betic-Rif-Alboran subduction zone. A tomographic inversion of the first arrival traveltimes along a 100-km long wide-angle seismic profile shot over 40 Ocean Bottom Seismometers, across the Margin offshore Mostaganem (Northwestern Algerian Margin) was conducted. The final model reveals striking feature in the deep structure of the margin from north to south: 1- the oceanic crust is as thin as 4-km, with velocities ranging from 5.0 to 7.1 km/s, covered by a 3.3 km thick sedimentary pile (seismic velocities from 1.5 to 5.0 km/s) characterized by an intense diapiric activity of the Messinian salt layer. 2- a sharp transition zone, less than 10 km wide, with seismic velocities intermediate between oceanic seismic velocities (observed northward) and continental seismic velocities (observed southward). This zone coincides with narrow and elongated pull apart basins imaged by multichannel seismic data. No evidence of volcanism nor of exhumed serpentinized upper mantle as described along many extensional continental margins are observed along this segment of the margin. 3- a thinned continental crust coincident with a rapid variation of the Moho depth imaged from 12 to ~20 km with a dip up to 50%. The seafloor bathymetry is showing a steep continental slope (>20%). Either normal or inverse faults are observed along MCS lines shot in the dip direction but they do not present large vertical displacement and could be related primarily to strike slip motion. These results support the hypothesis, that the margin offshore Mostaganem is not an extensional margin but rather a transform margin. There is little evidence of tectonic inversion as described eastward along the Kabylian Margin. Possibly strike slip motion affected the thinned continental crust and the transition zone suggesting that this margin is a vestige of the Subduction-Transform Edge Propagator (STEP) related to the westward migration of the Alboran block.

Changes in ice-margin processes and sediment routing during ice-sheet advance across a marginal moraine

USGS Publications Warehouse

Knight, P.G.; Jennings, C.E.; Waller, R.I.; Robinson, Z.P.

2007-01-01

Advance of part of the margin of the Greenland ice sheet across a proglacial moraine ridge between 1968 and 2002 caused progressive changes in moraine morphology, basal ice formation, debris release, ice-marginal sediment storage, and sediment transfer to the distal proglacial zone. When the ice margin is behind the moraine, most of the sediment released from the glacier is stored close to the ice margin. As the margin advances across the moraine the potential for ice-proximal sediment storage decreases and distal sediment flux is augmented by reactivation of moraine sediment. For six stages of advance associated with distinctive glacial and sedimentary processes we describe the ice margin, the debris-rich basal ice, debris release from the glacier, sediment routing into the proglacial zone, and geomorphic processes on the moraine. The overtopping of a moraine ridge is a significant glaciological, geomorphological and sedimentological threshold in glacier advance, likely to cause a distinctive pulse in distal sediment accumulation rates that should be taken into account when glacial sediments are interpreted to reconstruct glacier fluctuations. ?? 2007 Swedish Society for Anthropology and Geography.

Strain distribution across magmatic margins during the breakup stage: Seismicity patterns in the Afar rift zone

NASA Astrophysics Data System (ADS)

Brown, C.; Ebinger, C. J.; Belachew, M.; Gregg, T.; Keir, D.; Ayele, A.; Aronovitz, A.; Campbell, E.

2008-12-01

Fault patterns record the strain history along passive continental margins, but geochronological constraints are, in general, too sparse to evaluate these patterns in 3D. The Afar depression in Ethiopia provides a unique setting to evaluate the time and space relations between faulting and magmatism across an incipient passive margin that formed above a mantle plume. The margin comprises a high elevation flood basalt province with thick, underplated continental crust, a narrow fault-line escarpment underlain by stretched and intruded crust, and a broad zone of highly intruded, mafic crust lying near sealevel. We analyze fault and seismicity patterns across and along the length of the Afar rift zone to determine the spatial distribution of strain during the final stages of continental breakup, and its relation to active magmatism and dike intrusions. Seismicity data include historic data and 2005-2007 data from the collaborative US-UK-Ethiopia Afar Geodynamics Project that includes the 2005-present Dabbahu rift episode. Earthquake epicenters cluster within discrete, 50 km-long magmatic segments that lack any fault linkage. Swarms also cluster along the fault-line scarp between the unstretched and highly stretched Afar rift zone; these earthquakes may signal release of stresses generated by large lateral density contrasts. We compare Coulomb static stress models with focal mechanisms and fault kinematics to discriminate between segmented magma intrusion and crank- arm models for the central Afar rift zone.

Semidiurnal temperature changes caused by tidal front movements in the warm season in seabed habitats on the georges bank northern margin and their ecological implications.

PubMed

Guida, Vincent G; Valentine, Page C; Gallea, Leslie B

2013-01-01

Georges Bank is a large, shallow feature separating the Gulf of Maine from the Atlantic Ocean. Previous studies demonstrated a strong tidal-mixing front during the warm season on the northern bank margin between thermally stratified water in the Gulf of Maine and mixed water on the bank. Tides transport warm water off the bank during flood tide and cool gulf water onto the bank during ebb tide. During 10 days in August 2009, we mapped frontal temperatures in five study areas along ∼100 km of the bank margin. The seabed "frontal zone", where temperature changed with frontal movment, experienced semidiurnal temperature maxima and minima. The tidal excursion of the frontal boundary between stratified and mixed water ranged 6 to 10 km. This "frontal boundary zone" was narrower than the frontal zone. Along transects perpendicular to the bank margin, seabed temperature change at individual sites ranged from 7.0°C in the frontal zone to 0.0°C in mixed bank water. At time series in frontal zone stations, changes during tidal cycles ranged from 1.2 to 6.1°C. The greatest rate of change (-2.48°C hr(-1)) occurred at mid-ebb. Geographic plots of seabed temperature change allowed the mapping of up to 8 subareas in each study area. The magnitude of temperature change in a subarea depended on its location in the frontal zone. Frontal movement had the greatest effect on seabed temperature in the 40 to 80 m depth interval. Subareas experiencing maximum temperature change in the frontal zone were not in the frontal boundary zone, but rather several km gulfward (off-bank) of the frontal boundary zone. These results provide a new ecological framework for examining the effect of tidally-driven temperature variability on the distribution, food resources, and reproductive success of benthic invertebrate and demersal fish species living in tidal front habitats.

Structure and evolution of the eastern Gulf of Aden conjugate margins from seismic reflection data

NASA Astrophysics Data System (ADS)

d'Acremont, Elia; Leroy, Sylvie; Beslier, Marie-Odile; Bellahsen, Nicolas; Fournier, Marc; Robin, Cécile; Maia, Marcia; Gente, Pascal

2005-03-01

The Gulf of Aden is a young and narrow oceanic basin formed in Oligo-Miocene time between the rifted margins of the Arabian and Somalian plates. Its mean orientation, N75°E, strikes obliquely (50°) to the N25°E opening direction. The western conjugate margins are masked by Oligo-Miocene lavas from the Afar Plume. This paper concerns the eastern margins, where the 19-35 Ma breakup structures are well exposed onshore and within the sediment-starved marine shelf. Those passive margins, about 200 km distant, are non-volcanic. Offshore, during the Encens-Sheba cruise we gathered swath bathymetry, single-channel seismic reflection, gravity and magnetism data, in order to compare the structure of the two conjugate margins and to reconstruct the evolution of the thinned continental crust from rifting to the onset of oceanic spreading. Between the Alula-Fartak and Socotra major fracture zones, two accommodation zones trending N25°E separate the margins into three N110°E-trending segments. The margins are asymmetric: offshore, the northern margin is narrower and steeper than the southern one. Including the onshore domain, the southern rifted margin is about twice the breadth of the northern one. We relate this asymmetry to inherited Jurassic/Cretaceous rifts. The rifting obliquity also influenced the syn-rift structural pattern responsible for the normal faults trending from N70°E to N110°E. The N110°E fault pattern could be explained by the decrease of the influence of rift obliquity towards the central rift, and/or by structural inheritance. The transition between the thinned continental crust and the oceanic crust is characterized by a 40 km wide zone. Our data suggest that its basement is made up of thinned continental crust along the southern margin and of thinned continental crust or exhumed mantle, more or less intruded by magmatic rocks, along the northern margin.

Comparison of the tectonics and geophysics of the major structural belts between the northern and southern continental margins of the South China Sea

NASA Astrophysics Data System (ADS)

Xia, Kan-yuan; Huang, Ci-liu; Jiang, Shao-ren; Zhang, Yi-xiang; Su, Da-quan; Xia, Si-gao; Chen, Zhong-rong

1994-07-01

A comparison of the tectonics and geophysics of the major structural belts of the northern and the southern continental margins of South China Sea has been made, on the basis of measured geophysical data obtained by ourselves over a period of 8 years (1984-1991). This confirmed that the northern margin is a divergent one and the southern margin is characterized by clearly convergent features. The main extensional structures of the northern margin are, from north to south: (1) The Littoral Fault Belt, a tectonic boundary between the continental crust and a transitional zone, along the coast of the provinces of Guangdong and Fujian in South China. It is characterised by earthquake activities, high magnetic anomalies and a rapid change in crustal thickness. (2) The Northern and Southern Depression zones (i.e., the Pearl River Mouth Basin), this strikes NE-ENE and is a very large Cenozoic depression which extends from offshore Shantou westwards to Hainan Island. (3) The Central Uplift Zone. This includes the Dongsha Uplift, Shenhu Uplift and may be linked with the Penghu uplift and Taiwan shoals to the east, forming a large NE-striking uplift zone along the northern continental slope. It is characterized by high magnetic anomalies. (4) Southern Boundary Fault Belt of the transitional crust. This has positive gravity anomalies on the land side and negative ones on the sea side. (5) The Magnetic Quiet Zone. This is located south of the southern Boundary Fault Belt and between the continental margin and the Central Basin of the South China Sea. Magnetic anomalies in this belt are of small amplitude and low gradient. We consider the Magnetic Quiet Zone to be a very important tectonic zone. The major structures of southern continental margin southwards are: (1) The Northern Fault Belt of the Nansha Block. This extends along the continental slope north of the Liyue shoal (Reed Bank) and Zhongye reef, and is a tectonic boundary between oceanic crust and the Nansha Block continental crust. (2) The Nansha Block Uplift Zone. Due to the development of reefs and shoals, there are many channels and valleys. Our long-distance multichannel seismic profiles indicated that there are thick Paleogene sediments and thin Neogene sediments all over the central part of the block. (3) The Nansha Trough, a nappe structure formed by the southeastward drifting of Nansha Block and northwestward overthrusting of Palawan-northwest Borneo. (4) Zengmu Shoal Basin, southwest of the Nansha Block; the maximum thickness of Cenozoic strata is over 9 km in this important petroliferous basin.

DRI Technical Program: Emerging Dynamics of the Marginal Ice Zone Ice, Ocean and Atmosphere Interactions in the Arctic Marginal Ice Zone. Year 3 Annual Report

DTIC Science & Technology

2014-09-30

Institution The Scottish Association for Marine Science tmaksym@whoi.edu Phil.Hwang@sams.ac.uk LONG-TERM GOALS This DRI TECHNICAL PROGRAM (Emerging...jpw28@bas.ac.uk tmaksym@whoi.edu Co-PRINCIPAL INVESTIGATOR: Byongjun (Phil) Hwang The Scottish Association for Marine Science Phil.Hwang@sams.ac.uk 2

Genetic Testing Plus Irinotecan in Treating Patients With Solid Tumors or Lymphoma

ClinicalTrials.gov

2013-01-23

AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific

Vorinostat in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma and Liver Dysfunction

ClinicalTrials.gov

2014-02-21

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

PXD101 and 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma

ClinicalTrials.gov

2013-05-15

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

Enhancement of Speed Margins for 16× Digital Versatile Disc-Random Access Memory

NASA Astrophysics Data System (ADS)

Watanabe, Koichi; Minemura, Hiroyuki; Miyamoto, Makoto; Iimura, Makoto

2006-02-01

We have evaluated the speed margins of write/read 16× digital versatile disc-random access memory (DVD-RAM) test discs using write strategies for 6--16× constant angular velocity (CAV) control. Our approach is to determine the writing parameters for the middle zones by interpolating the zone numbers. Using this interpolation strategy, we successfully obtained overwrite jitter values of less than 8% and bit error rates of less than 10-5 in 6--16× DVD-RAM. Moreover, we confirmed that the speed margins were ± 20% for a 6--16× CAV.

An overview of dry-wet climate variability among monsoon-westerly regions and the monsoon northernmost marginal active zone in China

NASA Astrophysics Data System (ADS)

Qian, Weihong; Ding, Ting; Hu, Haoran; Lin, Xiang; Qin, Aimin

2009-07-01

Climate in mainland China can be divided into the monsoon region in the southeast and the westerly region in the northwest as well as the intercross zone, i.e., the monsoon northernmost marginal active zone that is oriented from Southwest China to the upper Yellow River, North China, and Northeast China. In the three regions, dry-wet climate changes are directly linked to the interaction of the southerly monsoon flow on the east side of the Tibetan Plateau and the westerly flow on the north side of the Plateau from the inter-annual to inter-decadal timescales. Some basic features of climate variability in the three regions for the last half century and the historical hundreds of years are reviewed in this paper. In the last half century, an increasing trend of summer precipitation associated with the enhancing westerly flow is found in the westerly region from Xinjiang to northern parts of North China and Northeast China. On the other hand, an increasing trend of summer precipitation along the Yangtze River and a decreasing trend of summer precipitation along the monsoon northernmost marginal active zone are associated with the weakening monsoon flow in East Asia. Historical documents are widely distributed in the monsoon region for hundreds of years and natural climate proxies are constructed in the non-monsoon region, while two types of climate proxies can be commonly found over the monsoon northernmost marginal active zone. In the monsoon region, dry-wet variation centers are altered among North China, the lower Yangtze River, and South China from one century to another. Dry or wet anomalies are firstly observed along the monsoon northernmost marginal active zone and shifted southward or southeastward to the Yangtze River valley and South China in about a 70-year timescale. Severe drought events are experienced along the monsoon northernmost marginal active zone during the last 5 centuries. Inter-decadal dry-wet variations are depicted by natural proxies for the last 4-5 centuries in several areas over the non-monsoon region. Some questions, such as the impact of global warming on dry-wet regime changes in China, complex interactions between the monsoon and westerly flows in Northeast China, and the integrated multi-proxy analysis throughout all of China, are proposed.

Development of continental margins of the Atlantic Ocean and successive breakup of the Pangaea-3 supercontinent

NASA Astrophysics Data System (ADS)

Melankholina, E. N.; Sushchevskaya, N. M.

2017-01-01

Comparative tectonic analysis of passive margins of the Atlantic Ocean has been performed. Tectonotypes of both volcanic and nonvolcanic margins are described, and their comparison with other passive Atlantic margins is given. The structural features of margins, peculiarities of magmatism, its sources and reasons for geochemical enrichment of melts are discussed. The important role of melting of the continental lithosphere in the development of magmatism is demonstrated. Enriched EM I and EM II sources are determined for the lower parts of the volcanic section, and a depleted or poorly enriched source is determined for the upper parts of the volcanic section based on isotope data. The conclusions of the paper relate to tectonic settings of the initial occurrence of magmatism and rifting and breakup during the period of opening of the Mesozoic Ocean. It was found out that breakup and magmatism at proximal margins led only to insignificant structural transformations and reduction of the thickness of the ancient continental crust, while very important magmatic events happened later in the distal zone. New growth of magmatic crust at the stage of continental breakup is determined as a typical feature of distal zones of the margins under study. The relationship of development of margins with the impact of deep plumes as the source of magmatic material or a heat source only is discussed. Progradation of the zone of extension and breakup into the areas of cold lithosphere of the Atlantic and the formation of a single tectonomagmatic system of the ocean are under consideration.

17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Advanced Epithelial Cancer, Malignant Lymphoma, or Sarcoma

ClinicalTrials.gov

2013-02-06

AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Chondrosarcoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Nodal Marginal Zone B-cell Lymphoma; Ovarian Sarcoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Osteosarcoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Uterine Sarcoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Stage IV Uterine Sarcoma; Unspecified Adult Solid Tumor, Protocol Specific

Incorporating Cutting Edge Scientific Results from the Margins-Geoprisms Program into the Undergraduate Curriculum: The Subduction Factory

NASA Astrophysics Data System (ADS)

Penniston-Dorland, S.; Stern, R. J.; Edwards, B. R.; Kincaid, C. R.

2014-12-01

The NSF-MARGINS Program funded a decade of research on continental margin processes. The NSF-GeoPRISMS Mini-lesson Project, funded by NSF-TUES, is designed to integrate fundamental results from the MARGINS program into open-source college-level curriculum. Three Subduction Factory (SubFac) mini-lessons were developed as part of this project. These include hands-on examinations of data sets representing 3 key components of the subduction zone system: 1) Heat transfer in the subducted slab; 2) Metamorphic processes happening at the plate interface; and 3) Typical magmatic products of arc systems above subduction zones. Module 1: "Slab Temperatures Control Melting in Subduction Zones, What Controls Slab Temperature?" allows students to work in groups using beads rolling down slopes as an analog for the mathematics of heat flow. Using this hands-on, exploration-based approach, students develop an intuition for the mathematics of heatflow and learn about heat conduction and advection in the subduction zone environment. Module 2: "Subduction zone metamorphism" introduces students to the metamorphic rocks that form as the subducted slab descends and the mineral reactions that characterize subduction-related metamorphism. This module includes a suite of metamorphic rocks available for instructors to use in a lab, and exercises in which students compare pressure-temperature estimates obtained from metamorphic rocks to predictions from thermal models. Module 3: "Central American Arc Volcanoes, Petrology and Geochemistry" introduces students to basic concepts in igneous petrology using the Central American volcanic arc, a MARGINS Subduction Factory focus site, as an example. The module relates data from two different volcanoes - basaltic Cerro Negro (Nicaragua) and andesitic Ilopango (El Salvador) including hand sample observations and major element geochemistry - to explore processes of mantle and crustal melting and differentiation in arc volcanism.

Marginal zone lymphoma: old, new, targeted, and epigenetic therapies

PubMed Central

Joshi, Monika; Sheikh, Hassan; Abbi, Kamal; Long, Sarah; Sharma, Kamal; Tulchinsky, Mark

2012-01-01

Marginal zone lymphoma (MZL) is an indolent B-cell lymphoma arising from marginal zone B-cells present in lymph nodes and extranodal tissues. MZL comprises 5–17% of all non-Hodgkin’s lymphomas in adults. The World Health Organization categorizes MZL into three distinct types based on their site of impact: (1) splenic marginal zone lymphoma (SMZL); (2) nodal marginal zone lymphoma (NMZL); (3) extranodal mucosa-associated lymphoid tissue (MALT) lymphoma, which can be subdivided into gastric and nongastric. The subgroups of MZL share some common features but are different in their biology and behavior. Owing to the rarity of MZL there are few randomized trials available comparing various treatment options and therefore treatment is controversial, lacking standard guidelines. Treatment should be patient tailored and can range from a ‘watchful waiting’ approach for asymptomatic patients without cytopenias to surgery or localized radiation therapy. Rituximab in combination with chemotherapy has resulted in longer failure-free survival than chemotherapy alone in patients with SMZL. Helicobacter pylori positive gastric MALT shows a good response rate to triple antibiotic therapy. Newer therapies such as bendamustine, everolimus, lenalidomide, vorinostat and phosphoinositide 3-kinase inhibitors are in clinical trials for patients with relapsed or refractory MZL and have shown promising results. We are presently conducting clinical trials testing the efficacy of the epigenetic activity of cladribine as a hypomethylating agent in combination with the histone deacetylase inhibitor (HDACi) vorinostat and rituximab in patients with MZL. Further studies with the newer agents should be done both in newly diagnosed or relapsed/refractory MZL to streamline the care and to avoid the use of toxic chemotherapies as initial treatment. PMID:23616915

Xmsx-1 modifies mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo.

PubMed

Maeda, R; Kobayashi, A; Sekine, R; Lin, J J; Kung, H; Maéno, M

1997-07-01

This study analyzes the expression and the function of Xenopus msx-1 (Xmsx-1) in embryos, in relation to the ventralizing activity of bone morphogenetic protein-4 (BMP-4). Expression of Xmsx-1 was increased in UV-treated ventralized embryos and decreased in LiCl-treated dorsalized embryos at the neurula stage (stage 14). Whole-mount in situ hybridization analysis showed that Xmsx-1 is expressed in marginal zone and animal pole areas, laterally and ventrally, but not dorsally, at mid-gastrula (stage 11) and late-gastrula (stage 13) stages. Injection of BMP-4 RNA, but not activin RNA, induced Xmsx-1 expression in the dorsal marginal zone at the early gastrula stage (stage 10+), and introduction of a dominant negative form of BMP-4 receptor RNA suppressed Xmsx-1 expression in animal cap and ventral marginal zone explants at stage 14. Thus, Xmsx-1 is a target gene specifically regulated by BMP-4 signaling. Embryos injected with Xmsx-1 RNA in dorsal blastomeres at the 4-cell stage exhibited a ventralized phenotype, with microcephaly and swollen abdomen. Histological observation and immunostaining revealed that these embryos had a large block of muscle tissue in the dorsal mesodermal area instead of notochord. On the basis of molecular marker analysis, however, the injection of Xmsx-1 RNA did not induce the expression of alpha-globin, nor reduce cardiac alpha-actin in dorsal marginal zone explants. Furthermore, a significant amount of alpha-actin was induced and alpha-globin was turned off in the ventral marginal zone explants injected with Xmsx-1. These results indicated that Xmsx-1 is a target gene of BMP-4 signaling, but possesses a distinct activity on dorsal-ventral patterning of mesodermal tissues.

Investigations of Spatial and Temporal Variability of Ocean and Ice Conditions in and Near the Marginal Ice Zone. The “Marginal Ice Zone Observations and Processes Experiment” (MIZOPEX) Final Campaign Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeMott, P. J.; Hill, T. C.J.

Despite the significance of the marginal ice zones of the Arctic Ocean, basic parameters such as sea surface temperature (SST) and a range of sea-ice characteristics are still insufficiently understood in these areas, and especially so during the summer melt period. The field campaigns summarized here, identified collectively as the “Marginal Ice Zone Ocean and Ice Observations and Processes Experiment” (MIZOPEX), were funded by U.S. National Aeronautic and Space Administration (NASA) with the intent of helping to address these information gaps through a targeted, intensive observation field campaign that tested and exploited unique capabilities of multiple classes of unmanned aerialmore » systems (UASs). MIZOPEX was conceived and carried out in response to NASA’s request for research efforts that would address a key area of science while also helping to advance the application of UASs in a manner useful to NASA for assessing the relative merits of different UASs. To further exercise the potential of unmanned systems and to expand the science value of the effort, the field campaign added further challenges such as air deployment of miniaturized buoys and coordinating missions involving multiple aircraft. Specific research areas that MIZOPEX data were designed to address include relationships between ocean skin temperatures and subsurface temperatures and how these evolve over time in an Arctic environment during summer; variability in sea-ice conditions such as thickness, age, and albedo within the marginal ice zone (MIZ); interactions of SST, salinity, and ice conditions during the melt cycle; and validation of satellite-derived SST and ice concentration fields provided by satellite imagery and models.« less

Immunohistochemical analysis of the novel marginal zone B-cell marker IRTA1 in malignant lymphoma.

PubMed

Ikeda, Jun-Ichiro; Kohara, Masaharu; Tsuruta, Yoko; Nojima, Satoshi; Tahara, Shinichiro; Ohshima, Kenji; Kurashige, Masako; Wada, Naoki; Morii, Eiichi

2017-01-01

Marginal zone lymphoma (MZL) is a low-grade B-cell lymphoma derived from marginal zone B cells. Because of a lack of specific immunohistochemical markers, MZL is mainly diagnosed based on the cytological appearance and growth pattern of the tumor. Marginal zone B cells were recently shown to selectively express immunoglobulin superfamily receptor translocation-associated 1 (IRTA1), but the antibody used in that study is not commercially available. We therefore investigated the IRTA1 expression in nonneoplastic lymphoid tissues and 261 malignant lymphomas, examining the ability of a commercially available antibody to accurately diagnose MZL. Among 37 MZLs, 23 of 25 extranodal MZLs of mucosa-associated lymphoid tissue (MALT lymphomas), 3 of 6 splenic MZLs and 3 of 6 nodal MZLs were positive for IRTA1. Among the 98 diffuse large B-cell lymphomas, 33 were positive for IRTA1, including 1 of 38 follicular lymphomas, and all precursor B-lymphoblastic (2/2) and T-lymphoblastic (7/7) leukemia/lymphomas. Other mature B-cell and T-cell lymphomas, and Hodgkin lymphoma were negative for IRTA1. In MALT lymphoma, positive cells were detected mainly in intraepithelial and subepithelial marginal zone B cells. In 1 case of grade 3 follicular lymphoma, IRTA1 was also expressed in the area of large cell transformation. When tumors were classified as germinal center B cell-like (GCB) or non-GCB using the algorithm of Hans, positive expression of IRTA1 was correlated significantly with non-GCB diffuse large B-cell lymphomas (P < .05). These results demonstrated the ability of the commercially available IRTA1 antibody to distinguish MALT lymphoma from other low-grade B-cell lymphomas. Copyright © 2016 Elsevier Inc. All rights reserved.

A viscoplastic shear-zone model for deep (15-50 km) slow-slip events at plate convergent margins

NASA Astrophysics Data System (ADS)

Yin, An; Xie, Zhoumin; Meng, Lingsen

2018-06-01

A key issue in understanding the physics of deep (15-50 km) slow-slip events (D-SSE) at plate convergent margins is how their initially unstable motion becomes stabilized. Here we address this issue by quantifying a rate-strengthening mechanism using a viscoplastic shear-zone model inspired by recent advances in field observations and laboratory experiments. The well-established segmentation of slip modes in the downdip direction of a subduction shear zone allows discretization of an interseismic forearc system into the (1) frontal segment bounded by an interseismically locked megathrust, (2) middle segment bounded by episodically locked and unlocked viscoplastic shear zone, and (3) interior segment that slips freely. The three segments are assumed to be linked laterally by two springs that tighten with time, and the increasing elastic stress due to spring tightening eventually leads to plastic failure and initial viscous shear. This simplification leads to seven key model parameters that dictate a wide range of mechanical behaviors of an idealized convergent margin. Specifically, the viscoplastic rheology requires the initially unstable sliding to be terminated nearly instantaneously at a characteristic velocity, which is followed by stable sliding (i.e., slow-slip). The characteristic velocity, which is on the order of <10-7 m/s for the convergent margins examined in this study, depends on the (1) effective coefficient of friction, (2) thickness, (3) depth, and (4) viscosity of the viscoplastic shear zone. As viscosity decreases exponentially with temperature, our model predicts faster slow-slip rates, shorter slow-slip durations, more frequent slow-slip occurrences, and larger slow-slip magnitudes at warmer convergent margins.

Crustal structure of Baffin Bay from constrained 3-D gravity inversion and deformable plate tectonic models

NASA Astrophysics Data System (ADS)

Welford, J. Kim; Peace, Alexander L.; Geng, Meixia; Dehler, Sonya A.; Dickie, Kate

2018-05-01

Mesozoic to Cenozoic continental rifting, breakup, and spreading between North America and Greenland led to the opening, from south to north, of the Labrador Sea and eventually Baffin Bay between Baffin Island, northeast Canada, and northwest Greenland. Baffin Bay lies at the northern limit of this extinct rift, transform, and spreading system and remains largely underexplored. With the sparsity of existing crustal-scale geophysical investigations of Baffin Bay, regional potential field methods and quantitative deformation assessments based on plate reconstructions provide two means of examining Baffin Bay at the regional scale and drawing conclusions about its crustal structure, its rifting history, and the role of pre-existing structures in its evolution. Despite the identification of extinct spreading axes and fracture zones based on gravity data, insights into the nature and structure of the underlying crust have only been gleaned from limited deep seismic experiments, mostly concentrated in the north and east where the continental shelf is shallower and wider. Baffin Bay is partially underlain by oceanic crust with zones of variable width of extended continental crust along its margins. 3-D gravity inversions, constrained by bathymetric and depth to basement constraints, have generated a range of 3-D crustal density models that collectively reveal an asymmetric distribution of extended continental crust, approximately 25-30 km thick, along the margins of Baffin Bay, with a wider zone on the Greenland margin. A zone of 5 to 13 km thick crust lies at the centre of Baffin Bay, with the thinnest crust (5 km thick) clearly aligning with Eocene spreading centres. The resolved crustal thicknesses are generally in agreement with available seismic constraints, with discrepancies mostly corresponding to zones of higher density lower crust along the Greenland margin and Nares Strait. Deformation modelling from independent plate reconstructions using GPlates of the rifted margins of Baffin Bay was performed to gauge the influence of original crustal thickness and the width of the deformation zone on the crustal thicknesses obtained from the gravity inversions. These results show the best match with the results from the gravity inversions for an original unstretched crustal thickness of 34-36 km, consistent with present-day crustal thicknesses derived from teleseismic studies beyond the likely continentward limits of rifting around the margins of Baffin Bay. The width of the deformation zone has only a minimal influence on the modelled crustal thicknesses if the zone is of sufficient width that edge effects do not interfere with the main modelled domain.

Slab geometry of the South American margin from joint inversion of body waves and surface waves

NASA Astrophysics Data System (ADS)

Porritt, R. W.; Ward, K. M.; Porter, R. C.; Portner, D. E.; Lynner, C.; Beck, S. L.; Zandt, G.

2016-12-01

The western margin of South America is a long subduction zone with a complex, highly three -dimensional geometry. The first order structure of the slab has previously been inferred from seismicity patterns and locations of volcanoes, but confirmation of the slab geometry by seismic imaging for the entire margin has been limited by either shallow, lithospheric scale models or broader, upper mantle images, often defined on a limited spatial footprint. Here, we present new teleseismic tomographic SV seismic models of the upper mantle from 10°S to 40°S along the South American subduction zone with resolution to a depth of 1000 km as inferred from checkerboard tests. In regions near the Peru Bolivia border (12°S to 18°S) and near central Chile and western Argentina (29.5°S to 33°S) we jointly invert the multi-band direct S and SKS relative delay times with Rayleigh wave phase velocities from ambient noise and teleseismic surface wave tomography. This self-consistent model provides information from the upper crust to below the mantle transition zone along the western margin in these two regions. This consistency allows tracing the slab from the South American coastline to the sub-transition zone upper mantle. From this model we image several features, but most notable is a significant eastward step near the southern edge of the margin (24°-30° S). West of this step, a large high shear velocity body is imaged in the base of and below the transition zone. We suggest this may be a stagnant slab, which is descending into the lower mantle now that it is no longer attached to the surface. This suggests a new component to the subduction history of western South America when an older slab lead the convergence before anchoring in the transition zone, breaking off from the surface, and being overtaken by the modern, actively subducting slab now located further east.

Satellite and aircraft passive microwave observations during the Marginal Ice Zone Experiment in 1984

NASA Technical Reports Server (NTRS)

Gloersen, Per; Campbell, William J.

1988-01-01

This paper compares satellite data on the marginal ice zone obtained during the Marginal Ice Zone Experiment in 1984 by Nimbus 7 with simultaneous mesoscale aircraft (in particular, the NASA CV-990 airborne laboratory) and surface observations. Total and multiyear sea ice concentrations calculated from the airborne multichannel microwave radiometer were found to agree well with similar calculations using the Nimbus SMMR data. The temperature dependence of the determination of multiyear sea-ice concentration near the melting point was found to be the same for both airborne and satellite data. It was found that low total ice concentrations and open-water storm effects near the ice edge could be reliably distinguished by means of spectral gradient ratio, using data from the 0.33-cm and the 1.55-cm radiometers.

Spleen deposition of Cryptococcus neoformans capsular glucuronoxylomannan in rodents occurs in red pulp macrophages and not marginal zone macrophages expressing the C-type lectin SIGN-R1.

PubMed

De Jesus, Magdia; Park, Chae Gyu; Su, Ya; Goldman, David L; Steinman, Ralph M; Casadevall, Arturo

2008-03-01

The fate of microbial polysaccharides in host tissues is an important consideration because these compounds are often immune modulators. Splenic marginal zone macrophages that express the C-type lectin receptor SIGN-R1, take up neutral polysaccharides such as dextran and the capsular polysaccharide of Streptococcus pneumoniae. Given that the major component of Cryptococcus neoformans capsular polysaccharide, glucuronoxylomannan (GXM), localizes in the spleen when injected intravenously, we investigated whether GXM uptake was mediated by splenic macrophages expressing the SIGN-R1 receptor in mice. No significant differences in the amount and location of GXM deposition were detected in the spleens of mice treated with a SIGN-R1 blocking antibody when compared to controls. Similarly, a blocking antibody to Dectin-1, a co-receptor of -SIGN-R1, had no effects on GXM distribution within the spleen. Histological examination of spleens from mice and rats injected with FITC-Dextran and GXM revealed no significant co-localization, with Dextran and GXM being found in marginal and red pulp macrophages, respectively. Hence we conclude that GXM was not deposited in marginal zone macrophages. However, GXM deposition was found in the red pulp. These results indicate that there is a selective localization of these polysaccharides to different receptors such as SIGN-R1 for FITC dextran in marginal zone and a to-be-identified receptor selectively expressed by red pulp macrophages for GXM.

Long-term seismic observations along Myanmar-Sunda subduction margin: insights for 2004 M w > 9.0 earthquake

NASA Astrophysics Data System (ADS)

Khan, Prosanta Kumar; Banerjee, Jayashree; Shamim, Sk; Mohanty, Manoranjan

2018-03-01

The present study investigates the temporal variation of few seismic parameters between the Myanmar (Zone I), Andaman-Nicobar-Northwest Sumatra (Zone II), Southeast Sumatra-West Indonesia (Zone III) and East Indonesia (Zone IV) converging boundaries in reference to the generation of 26 December 2004 M w > 9.0 off-Sumatra mega-earthquake event. The four segments are distinguished based on tectonics parameters, distinct geological locations, great earthquake occurrences, and the Wadati-Benioff zone characteristics. Two important seismic parameters such as seismic energy and b values are computed over a time-window of 6-month period during the entire 1976-2013 period for these segments. The b values show a constant decrease in Zones II, III, and IV, whereas the Zone I does not show any such pattern prior to the 2004 mega-event. The release of seismic energy was also gradually decreasing in Zones II and III till the 2004 event, and little similar pattern was also noted in Zone IV. This distinct observation might be indicating that the stress accumulation was dominant near the Sumatra-Java area located towards southeast of Zone II and northwest of Zone III. The released strain energy during the 2004 event was subsequently migrated towards north, rupturing 1300 km of the boundary between the Northwest Sumatra and the North Andaman. The occurrence of 2004 mega-event was apparently concealed behind the long-term seismic quiescence existing near the Sumatra and Nicobar margin. A systematic study of the patterns of seismic energy release and b values, and the long-term observation of collective behaviour of the margin tectonics might have had given clues to the possibility of the 2004 mega-event.

Acoustic Transients of the Marginal Sea Ice Zone: A Provisional Catalog

DTIC Science & Technology

1989-08-01

Arctic marine mammals is approximately 20 million individuals. Most of these inhabit the marginal sea ice zone (MIZ), but some species, such as ringed ...Food: molluscs, worms, sea urchins, Arctic cod, occasionally other marine mammals, e.g., ringed and bearded seals, narwhals. Dive: to 80 m...called for. TRANSIENT DESCRIPTION Recordings unavailable DATA SOURCE SERIAL _____ 21 SUPPORTING DATA SOURCE IRIS Ringed Seal, Phoca hispida Circumpolar

MIZEX. A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. II. A Science Plan for a Summer Marginal Ice Zone Experiment in the Fram Strait/Greenland Sea: 1984.

DTIC Science & Technology

1983-05-01

size and thickness characteris- tics. N’ore complete analysis will require combin- ing ice data with data obtained by the oceano - graphic... sol concentration and microwave brightness tem- perature. A long-range aircraft and a light aircraft Hying from Spitzbergen will study mesoscale

Terminal deoxynucleotidyl transferase in the diagnosis of leukemia and malignant lymphoma.

PubMed

Kung, P C; Long, J C; McCaffrey, R P; Ratliff, R L; Harrison, T A; Baltimore, D

1978-05-01

Neoplastic cells from 253 patients with leukemia and 46 patients with malignant lymphoma were studied for the presence of terminal deoxynucleotidyl transferase (TdT) by biochemical and fluorescent antibody technics. TdT was detected in circulating blast cells from 73 of 77 patients with acute lymphoblastic leukemia, 24 of 72 patients with chronic myelogenous leukemia examined during the blastic phase of the disorder and in cell suspensions of lymph nodes from nine of nine patients with diffuse lymphoblastic lymphoma. Blast cells from six of 10 patients with acute undifferentiated leukemia were TdT positive, but the enzyme was found in only two of 55 patients with acute myeloblastic leukemia. TdT was not detected in other lymphocytic or granulocytic leukemias or in other types of malignant lymphomas. The fluorescent antibody assay for TdT permits rapid and specific identification of the enzyme in single cells. The TdT assay is clinically useful in confirming the diagnosis of acute lymphoblastic leukemia, evaluating patients with blastic chronic myelogenous leukemia, and distinguishing patients with lymphoblastic lymphoma, whose natural history includes rapid extranodal dissemination, from patients with other poorly differentiated malignant lymphomas.

Long-term survival following autologous and allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm.

PubMed

Aoki, Tomohiro; Suzuki, Ritsuro; Kuwatsuka, Yachiyo; Kako, Shinichi; Fujimoto, Katsuya; Taguchi, Jun; Kondo, Tadakazu; Ohata, Kinya; Ito, Toshiro; Kamoda, Yoshimasa; Fukuda, Takahiro; Ichinohe, Tatsuo; Takeuchi, Kengo; Izutsu, Koji; Suzumiya, Junji

2015-06-04

We sought to clarify the role of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN). We retrospectively identified 25 BPDCN patients (allo-HSCT, n = 14; auto-HSCT, n = 11) from registry data of the Japan Society for Hematopoietic Cell Transplantation and analyzed clinicopathologic data and clinical outcomes after transplantation. The median age at HSCT was 58 years (range, 17-67 years). All 11 patients who underwent auto-HSCT were in the first complete remission (CR1). With a median follow-up of 53.5 months, the overall survival rates at 4 years for patients who underwent auto-HSCT and allo-HSCT were 82% and 53% (P = .11), respectively, and progression-free survival rates were 73% and 48% (P = .14), respectively. Auto-HSCT for BPDCN in CR1 appears to provide promising results and deserves further evaluation in the setting of prospective trials. © 2015 by The American Society of Hematology.

New Insights into Passive Margin Development from a Global Deep Seismic Reflection Dataset

NASA Astrophysics Data System (ADS)

Bellingham, Paul; Pindell, James; Graham, Rod; Horn, Brian

2014-05-01

The kinematic and dynamic evolution of the world's passive margins is still poorly understood. Yet the need to replace reserves, a high oil price and advances in drilling technology have pushed the international oil and gas industry to explore in the deep and ultra-deep waters of the continental margins. To support this exploration and help understand these margins, ION-GXT has acquired, processed and interpreted BasinSPAN surveys across many of the world's passive margins. Observations from these data lead us to consider the modes of subsidence and uplift at both volcanic and non-volcanic margins. At non-volcanic margins, it appears that frequently much of the subsidence post-dates major rifting and is not thermal in origin. Rather the subsidence is associated with extensional displacement on a major fault or shear zone running at least as deep as the continental Moho. We believe that the subsidence is structural and is probably associated with the pinching out (boudinage) of the Lower Crust so that the Upper crust effectively collapses onto the mantle. Eventually this will lead to the exhumation of the sub-continental mantle at the sea bed. Volcanic margins present more complex challenges both in terms of imaging and interpretation. The addition of volcanic and plutonic material into the system and dynamic effects all impact subsidence and uplift. However, we will show some fundamental observations regarding the kinematic development of volcanic margins and especially SDRs which demonstate that the process of collapse and the development of shear zones within and below the crust are also in existence at this type of margin. A model is presented of 'magma welds' whereby packages of SDRs collapse onto an emerging sub-crustal shear zone and it is this collapse which creates the commonly observed SDR geometry. Examples will be shown from East India, Newfoundland, Brazil, Argentina and the Gulf of Mexico.

The continent-ocean transition at the mid-northern margin of the South China Sea

NASA Astrophysics Data System (ADS)

Gao, Jinwei; Wu, Shiguo; McIntosh, Kirk; Mi, Lijun; Yao, Bochu; Chen, Zeman; Jia, Liankai

2015-07-01

The northern margin of the South China Sea (SCS) has particular structural and stratigraphic characteristics that are somewhat different from those described in typical passive margin models. The differences are attributable to poly-phase tectonic movements and magmatic activity resulting from the interaction among the Eurasian, Philippine Sea and Indo-Australian plates. Based on several crustal-scale multi-channel seismic reflection profiles and satellite gravity data across the northern SCS margin, this paper analyzes the structures, volcanoes and deep crust of the continent-ocean transition zone (COT) at the mid-northern margin of the SCS to study the patterns and model of extension there. The results indicate that the COT is limited landward by basin-bounding faults near Baiyun sag and is bounded by seaward-dipping normal faults near the oceanic basin in our seismic lines. The shallow anatomy of the COT is characterized by rift depression, structural highs with igneous rock and/or a volcanic zone or a zone of tilted fault blocks at the distal edge. Gravity modeling revealed that a high velocity layer (HVL) with a 0.8-6-km thickness is frequently present in the slope below the lower crust. Our study shows that the HVL is only located in the eastern portion of the northern SCS margin based on the available geophysical data. We infer from this that the presence of an HVL is not required in the COT at the northern SCS margin. The magmatic intrusions and HVL may be related to partial melting caused by the decompression of a passive, upwelling asthenosphere, which resulted primarily in post-rifting underplating and magmatic emplacement or modification of the crust. Based on this study, we propose that an intermediate mode of rifting was active in the mid-northern margin of the SCS with characteristics that are closer to those of the magma-poor margins than those of volcanic margins.

Upregulation of autophagy and glycolysis markers in keloid hypoxic-zone fibroblasts: Morphological characteristics and implications.

PubMed

Ryoko, Okuno; Ito, Yuko; Eid, Nabil; Otsuki, Yoshinori; Kondo, Yoichi; Ueda, Koichi

2018-05-29

Keloid is a fibro-proliferative skin disorder with tumor-like behavior and dependence on anaerobic glycolysis (the Warburg effect), but its exact pathogenesis is unknown. Although autophagy is widely accepted as a lysosomal pathway for cell survival and cellular homeostasis (specifically upon exposure to stressors such as hypoxia), very few studies have investigated the involvement of autophagy and related glycolytic effectors in keloidogenesis. Here the authors examined the expression and cellular localization of autophagy proteins (LC3, pan-cathepsin), glycolytic markers (LDH, MCT1, MCT4) and the transcription factor HIF isoforms in human keloid samples using immunohistochemical analysis and double-labeling immunofluorescence methods. Based on H&E staining and expression of CD31, keloids were compartmentalized into hypoxic central and normoxic marginal zones. Vimentin-expressing fibroblasts in the central zone exhibited greater autophagy than their marginal-zone counterparts, as evidenced by increased LC3 puncta formation and co-localization with lysosomal pan-cathepsin. LDH (a lactate stimulator), MCT4 (a lactate exporter) and HIF-1 α expression levels were also higher in central-zone fibroblasts. Conversely, HIF-2 α expression was upregulated in fibroblasts and endothelial cells of the peripheral zone, while MCT1 was expressed in both zones. Taken together, these observations suggest that upregulation of autophagy and glycolysis markers in keloid hypoxic-zone fibroblasts may indicate a prosurvival mechanism allowing the extrusion of lactate to marginal-zone fibroblasts via metabolic coupling. The authors believe this is the first report on differential expression of autophagic and glycolytic markers in keloid-zone fibroblasts. The study results indicate that autophagy inhibitors and MCT4 blockers may have therapeutic implications in keloid treatment.

Necrotic ulcer: a manifestation of leukemia cutis.

PubMed

Aksu, Ayse Esra Koku; Saracoglu, Zeynep Nurhan; Sabuncu, Ilham; Ciftci, Evrim; Gulbas, Zafer; Isiksoy, Serap

2012-01-01

A 71-year-old man presented to our dermatological clinic with a 3-month history of a wound on his leg. He complained of weakness for the past few months. On his dermatological examination he had a 3x3-cm necrotic ulcer on his left tibia (Figure 1). On physical examination, there was 1 x 1-cm axillary lymphadenopathy. There was no other lymph node enlargement, hepatosplenomegaly, or gingival hypertrophy. Peripheral blood results showed 2.4x103/mm3 leukocytes (normal range 4-11 x 103/mm3) with 66% neutrophils. The hemoglobin value was 10.1 g/dL (13-18 g/dL), and the platelet count was 63x103/mm3 (150-440 x 103/mm3). No blasts were detected in a peripheral blood smear. His lactate dehydrogenase level was 567 U/L (240-480 U/L). All other results of blood chemistry were within normal limits. Punch biopsy of the skin lesion showed ulceration and dense dermal acute and chronic inflammation. There was a superficial and deep perivascular and periadnexal infiltrate of neoplastic cells composed of relatively abundant eosinophilic cytoplasm and large nuclei with blastic chromatin and occasional small nucleoli (Figure 2). Mitotic figures were prominent. Immunohistochemical stains were performed, and the neoplastic cells were CD3, CD20, CD138, and S100 protein negative. Myeloperoxidase and CD68 were positive. The histopathological findings were consistent with leukemic infiltration. Examination of bone marrow biopsy revealed that the blastic cells constituted more than 20% of the bone marrow cellularity. Cytogenetic analysis of bone marrow aspiration with fluorescence in situ hybridization was negative for inversion 16, t(8;21) and t(15;7). Histochemical stains for myeloperoxidase, sudan black, periodic acid-Schiff, and alpha naphthyl acetate were also negative. Blastic cells were DR, CD13, CD117, and CD34 positive and CD5, CD7, CD10, CD14, CD19, CD20, CD33, CD41, CD56, CD64, and CD79 negative according to flow cytometry immunophenotyping. Blastic cells were 35% in the bone marrow. Based on the findings of bone marrow examination, the patient was diagnosed as having acute myeloblastic leukeamia (AML) with minimal differentiation (subtype MO) according to French-American-British and World Health Organization classification. The examination of abdominal ultrasonography and thorocic and abominal computed tomography revealed no metastases. The patient was treated with chemotherapy that consisted of cytarabin and daunorubicin. After chemotherapy, the lesion regressed. One month after chemotherapy, the patient presented to the hospital with a complaint of fever. He was diagnosed with febrile neutropenia. He died of cardiac failure 12 months after appearance of skin infiltration.

Coupling of Waves, Turbulence and Thermodynamics Across the Marginal Ice Zone

DTIC Science & Technology

2013-09-30

under-predict the observed trend of declining sea ice area over the last decade. A potential explanation for this under-prediction is that models...are missing important feedbacks within the ocean- ice system. Results from the proposed research will contribute to improving the upper ocean and sea ...and solar-radiation-driven thermodynamic forcing in the marginal ice zone. Within the MIZ, the ocean- ice - albedo feedback mechanism is coupled to ice

The Transcription Factor Bright Plays a Role in Marginal Zone B Lymphocyte Development and Autoantibody Production

PubMed Central

Oldham, Athenia L.; Miner, Cathrine A.; Wang, Hong-Cheng; Webb, Carol F.

2011-01-01

Previous data suggested that constitutive expression of the transcription factor Bright (B cell regulator of immunoglobulin heavy chain transcription), normally tightly regulated during B cell differentiation, was associated with autoantibody production. Here we show that constitutive Bright expression results in skewing of mature B lineage subpopulations toward marginal zone cells at the expense of the follicular subpopulation. C57Bl/6 transgenic mice constitutively expressing Bright in B lineage cells generated autoantibodies that were not the result of global increases in immunoglobulin or of breaches in key tolerance checkpoints typically defective in other autoimmune mouse models. Rather, autoimmunity correlated with increased numbers of marginal zone B cells and alterations in the phenotype and gene expression profiles of lymphocytes within the follicular B cell compartment. These data suggest a novel role for Bright in the normal development of mature B cell subsets and in autoantibody production. PMID:21963220

Symmetrical primary cutaneous marginal zone lymphoma associated with rheumatoid arthritis.

PubMed

Yildirim, Fatma Elif; Karaduman, Ayşen; Hürmüz, Pervin; Ozyar, Enis; Barişta, Ibrahim; Sağlam, Arzu

2010-05-01

Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is an indolent low grade B cell lymphoma of the skin, with lack of extracutaneous involvement at the time of diagnosis. Herein we report the case of a patient with rheumatoid arthritis (RA) who developed symmetrical PCMZL lesions on both ear lobes. Lesions occurring symmetrically on ear lobes are more specific for cutaneous lymphoid hyperplasia (CLH) and this kind of symmetrical localization hasn't been reported for PCMZL before. PCMZL is considered to arise from a background of reactive lymphoid hyperplasia and this case point out the concept of CLH and PCMZL spectrum. Association of marginal zone lymphoma with rheumatoid arthritis and resolution of lesions together with the resolution of symptoms due to rheumatoid arthritis after rituximab therapy is another interesting point for this case. To the best of our knowledge PCMZL associated with RA has not been reported previously.

Correlation studies of passive and active microwave data in the marginal ice zone

NASA Technical Reports Server (NTRS)

Comiso, J. C.

1991-01-01

The microwave radiative and backscatter characteristics of sea ice in an Arctic marginal ice zone have been studied using near-simultaneous passive and active synthetic aperture radar microwave data. Intermediate-resolution multichannel passive microwave data were registered and analyzed. Passive and active microwave data generally complement each other as the two sensors are especially sensitive to different physical properties of the sea ice. In the inner pack, undeformed first-year ice is observed to have low backscatter values but high brightness temperatures while multiyear ice has generally high backscatter values and low brightness temperatures. However, in the marginal ice zone, the signature and backscatter for multiyear ice are considerably different and closer to those of first-year ice. Some floes identified by photography as snow-covered thick ice have backscatter similar to that of new ice or open water while brash ice has backscatter similar to or higher than that of ridged ice.

3-D Structure and Morphology of the S-reflector Detachment Fault, Offshore Galicia, Spain

NASA Astrophysics Data System (ADS)

Schuba, C. N.; Sawyer, D. S.; Gray, G. G.; Morgan, J.; Bull, J.; Shillington, D. J.; Jordan, B.; Reston, T. J.

2017-12-01

The crustal architecture of passive continental margins provides valuable clues for understanding rift initiation and evolution. The Galicia margin is an archetypal magma-poor margin displaying exhumed serpentinized mantle, and is an optimal setting in which to examine rift-related processes. A new 3-D seismic reflection volume images this margin in great detail. The S-reflector detachment fault, one of the most prominent structural features associated with the Galicia margin, is imaged as a continuous interface over an area of 600 km2. The top and base of the fault zone can be mapped independently, which enables seismic attribute analysis of this significant structure. RMS amplitude maps extracted from this interface show localized patches of high amplitude stripes that coincide with thickness variations of the fault zone and undulations in the bounding surfaces of the fault. These variations bear similarities to grooves on the fault surface such as slickensides, and appear to have developed as the fault zone evolved. These features thus represent good indicators of the kinematics of the fault system. In general, there is good correlation between S-reflector morphology and the overriding fault intersections; however this relationship does not appear to be present with the fault gouge thickness.

A comparison of the regional slope characteristics of Venus and earth - Implications for geologic processes on Venus

NASA Technical Reports Server (NTRS)

Sharpton, V. L.; Head, J. W., III

1986-01-01

The range of 3 degree by 3 degree regional slopes of the Earth and Venus is similar (approximately 0.0-2.4 degrees), although the surface distribution of these values differs significantly. On earth, cratonic and abyssal plains form extensive regions of 0.0 degree slope. Within these regions a variety of features (mid-ocean ridges, volcanic island chains, subduction zones, and floded mountains) have regional slope characteristics influenced by seafloor spreading and plate recycling, as well as an active weathering regime. The plains provinces of Venus are much more rugged than earth's plains and are marked by numerous closely spaced circular and linear features (0.1-0.2 degree regional slope) concentrated into broad linear zones of global extent. Although Venus highlands are bounded by narrow zones of relatively steep slope, the margins of Aphrodite Terra and Beta Regio are not as steep as earth's continental margins and appear to be best developed parallel to the trends of major chasmata within these regions. Ishtar Terra's margins are significantly steeper and more continuous than other highland margins and are comparable to passive margins on earth. The Venus highlands do not contain appreciable smooth, flat interior regions, implying that highland topography is not significantly modified by erosion or deposition.

Controls on continental strain partitioning above an oblique subduction zone, Northern Andes

NASA Astrophysics Data System (ADS)

Schütt, Jorina M.; Whipp, David M., Jr.

2016-04-01

Strain partitioning is a common process at obliquely convergent plate margins dividing oblique convergence into margin-normal slip on the plate-bounding fault and horizontal shearing on a strike-slip system parallel to the subduction margin. In subduction zones, strain partitioning in the upper continental plate is mainly controlled by the shear forces acting on the plate interface and the strength of the continental crust. The plate interface forces are influenced by the subducting plate dip angle and the obliquity angle between the normal to the plate margin and the convergence velocity vector, and the crustal strength of the continent is strongly affected by the presence or absence of a volcanic arc, with the presence of the volcanic arcs being common at steep subduction zones. Along the ˜7000 km western margin of South America the convergence obliquity, subduction dip angles and presence of a volcanic arc all vary, but strain partitioning is only observed along parts of it. This raises the questions, to what extent do subduction zone characteristics control strain partitioning in the overriding continental plate, and which factors have the largest influence? We address these questions using lithospheric-scale 3D numerical geodynamic experiments to investigate the influence of subduction dip angle, convergence obliquity, and weaknesses in the crust owing to the volcanic arc on strain partitioning behavior. We base the model design on the Northern Volcanic Zone of the Andes (5° N - 2° S), characterized by steep subduction (˜ 35°), a convergence obliquity between 31° -45° and extensive arc volcanism, and where strain partitioning is observed. The numerical modelling software (DOUAR) solves the Stokes flow and heat transfer equations for a viscous-plastic creeping flow to calculate velocity fields, thermal evolution, rock uplift and strain rates in a 1600 km x 1600 km box with depth 160 km. Subduction geometry and material properties are based on a simplified, generic subduction zone similar to the northern Andes. The upper surface is initially defined to resemble the Andes, but is free to deform during the experiments. We consider two main model designs, one with and one without a volcanic arc (weak continental zone). A relatively high angle of convergence obliquity is predicted to favor strain partitioning, but preliminary model results show no strain partitioning for a uniform continental crustal strength with a friction angle of Φ = 15° . However, strain partitioning does occur when including a weak zone in the continental crust resulting from arc volcanic activity with Φ = 5° . This results in margin-parallel northeastward translation of a continental sliver at 3.2 cm/year. The presence of the sliver agrees well with observations of a continental sliver identified by GPS measurements in the Northern Volcanic Zone with a translation velocity of about 1 cm/year, though the GPS-derived velocity may not be representative of the long-term rate of translation depending on whether the observation period includes one or more seismic cycles. Regardless, the observed behavior is consistent with the observed earthquake focal mechanisms and GPS measurements, suggesting significant northeastward transport of Andean crust along the margin of the northern Andes.

The western limits of the Seattle fault zone and its interaction with the Olympic Peninsula, Washington

USGS Publications Warehouse

A.P. Lamb,; L.M. Liberty,; Blakely, Richard J.; Pratt, Thomas L.; Sherrod, B.L.; Van Wijk, K.

2012-01-01

We present evidence that the Seattle fault zone of Washington State extends to the west edge of the Puget Lowland and is kinemati-cally linked to active faults that border the Olympic Massif, including the Saddle Moun-tain deformation zone. Newly acquired high-resolution seismic reflection and marine magnetic data suggest that the Seattle fault zone extends west beyond the Seattle Basin to form a >100-km-long active fault zone. We provide evidence for a strain transfer zone, expressed as a broad set of faults and folds connecting the Seattle and Saddle Mountain deformation zones near Hood Canal. This connection provides an explanation for the apparent synchroneity of M7 earthquakes on the two fault systems ~1100 yr ago. We redefi ne the boundary of the Tacoma Basin to include the previously termed Dewatto basin and show that the Tacoma fault, the southern part of which is a backthrust of the Seattle fault zone, links with a previously unidentifi ed fault along the western margin of the Seattle uplift. We model this north-south fault, termed the Dewatto fault, along the western margin of the Seattle uplift as a low-angle thrust that initiated with exhu-mation of the Olympic Massif and today accommodates north-directed motion. The Tacoma and Dewatto faults likely control both the southern and western boundaries of the Seattle uplift. The inferred strain trans-fer zone linking the Seattle fault zone and Saddle Mountain deformation zone defi nes the northern margin of the Tacoma Basin, and the Saddle Mountain deformation zone forms the northwestern boundary of the Tacoma Basin. Our observations and model suggest that the western portions of the Seattle fault zone and Tacoma fault are com-plex, require temporal variations in principal strain directions, and cannot be modeled as a simple thrust and/or backthrust system.

Geophysical evidence for the intersection of the St Paul, Cape Palmas and Grand Cess fracture zones with the continental margin of Liberia, West Africa

USGS Publications Warehouse

Behrendt, John C.; Schlee, J.; Robb, James M.

1974-01-01

PUBLISHED reconstructions of Gondwana continent1 (Fig. la) show a gap in fit near the junction of the Americas and Africa. To study this critical area, the Unitedgeo I made geophysical measurements and collected rock samples across the continental margin of Liberia (USGS-IDOE cruise leg 5) in November 1971. Figure Ib indicates the location of the 5,400 km of ship track on a generalised bathymetric map2. We shall discuss the data in detail elsewhere. Here we present the evidence for the existence of three fracture zones, two of which have not been reported previously, intersecting the continental margin at the north end of the South Atlantic, which remained closed probably until Cretaceous time. We suggest that Precambrian structures on the African continent controlled the location of these fracture zones. Figure Ic compares gravity and magnetic profiles and interpretations of the seismic profiles for three selected lines (27, 30 and 34) crossing the Grand Cess, Cape Palmas and St Paul fracture zones, respectively. ?? 1974 Nature Publishing Group.

PS-341 in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia in Blast Phase, or Myelodysplastic Syndrome

ClinicalTrials.gov

2013-01-22

Adult Acute Promyelocytic Leukemia (M3); Blastic Phase Chronic Myelogenous Leukemia; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Relapsing Chronic Myelogenous Leukemia

Pre-existing oblique transfer zones and transfer/transform relationships in continental margins: New insights from the southeastern Gulf of Aden, Socotra Island, Yemen

NASA Astrophysics Data System (ADS)

Bellahsen, N.; Leroy, S.; Autin, J.; Razin, P.; d'Acremont, E.; Sloan, H.; Pik, R.; Ahmed, A.; Khanbari, K.

2013-11-01

Transfer zones are ubiquitous features in continental rifts and margins, as are transform faults in oceanic lithosphere. Here, we present a structural study of the Hadibo Transfer Zone (HTZ), located in Socotra Island (Yemen) in the southeastern Gulf of Aden. There, we interpret this continental transfer fault zone to represent a reactivated pre-existing structure. Its trend is oblique to the direction of divergence and it has been active from the early up to the latest stages of rifting. One of the main oceanic fracture zones (FZ), the Hadibo-Sharbithat FZ, is aligned with and appears to be an extension of the HTZ and is probably genetically linked to it. Comparing this setting with observations from other Afro-Arabian rifts as well as with passive margins worldwide, it appears that many continental transfer zones are reactivated pre-existing structures, oblique to divergence. We therefore establish a classification system for oceanic FZ based upon their relationship with syn-rift structures. Type 1 FZ form at syn-rift structures and are late syn-rift to early syn-OCT. Type 2 FZ form during the OCT formation and Type 3 FZ form within the oceanic domain, after the oceanic spreading onset. The latter are controlled by far-field forces, magmatic processes, spreading rates, and oceanic crust rheology.

Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies

ClinicalTrials.gov

2018-05-24

Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Peripheral T-cell Lymphoma; Previously Treated Myelodysplastic Syndromes; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Splenic Marginal Zone Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage I Small Lymphocytic Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Waldenström Macroglobulinemia

Mechanisms underlying the organizer formation in Bufo arenarum embryos.

PubMed

Manes, M E; Nieto, O L

1989-06-01

In the early gastrula of Bufo arenarum the prospective mesoderm was previously identified as a marginal belt of grey cells. To analyze their differentiation capacity explants of these cells were cultured within ectodermal vesicles, in isolation and in combination with vegetal components. When cultured in isolation, dorsal and ventral fragments from the deep marginal zone behaved differently. Whilst ventral explants produced blood cells, dorsal explants failed to differentiate, remaining as masses of yolk-laden cells. On the other hand, both cultures were drastically modified when associated with superficial cells from the blastoporal zone, which caused the following effects: a) Promotion of differentiation in dorsal marginal explants, able now to produce notochordal and somitic structures, in addition to mesenchymatic cells. b) Promotion of dorsalization in ventral marginal explants, which changed their expected destiny developing axial components, similar to those furnished by "activated" dorso marginal explants. On the contrary, combined cultures of animal and vegetal pieces were unable to generate mesodermal structures. These studies suggest that the axial mesoderm, identified as the "organizer", develops from a marginal substrate of genuine mesodermal cells through a dorsalizing inductive stimulus originated in superficial periblastoporal cells.

Semidiurnal temperature changes caused by tidal front movements in the warm season in seabed habitats on the Georges Bank northern margin and their ecological implications

USGS Publications Warehouse

Guida, Vincent G.; Valentine, Page C.; Gallea, Leslie B.

2013-01-01

Georges Bank is a large, shallow feature separating the Gulf of Maine from the Atlantic Ocean. Previous studies demonstrated a strong tidal-mixing front during the warm season on the northern bank margin between thermally stratified water in the Gulf of Maine and mixed water on the bank. Tides transport warm water off the bank during flood tide and cool gulf water onto the bank during ebb tide. During 10 days in August 2009, we mapped frontal temperatures in five study areas along ∼100 km of the bank margin. The seabed “frontal zone”, where temperature changed with frontal movment, experienced semidiurnal temperature maxima and minima. The tidal excursion of the frontal boundary between stratified and mixed water ranged 6 to 10 km. This “frontal boundary zone” was narrower than the frontal zone. Along transects perpendicular to the bank margin, seabed temperature change at individual sites ranged from 7.0°C in the frontal zone to 0.0°C in mixed bank water. At time series in frontal zone stations, changes during tidal cycles ranged from 1.2 to 6.1°C. The greatest rate of change (-2.48°C hr-1) occurred at mid-ebb. Geographic plots of seabed temperature change allowed the mapping of up to 8 subareas in each study area. The magnitude of temperature change in a subarea depended on its location in the frontal zone. Frontal movement had the greatest effect on seabed temperature in the 40 to 80 m depth interval. Subareas experiencing maximum temperature change in the frontal zone were not in the frontal boundary zone, but rather several km gulfward (off-bank) of the frontal boundary zone. These results provide a new ecological framework for examining the effect of tidally-driven temperature variability on the distribution, food resources, and reproductive success of benthic invertebrate and demersal fish species living in tidal front habitats.

Wave-Ice interaction in the Marginal Ice Zone: Toward a Wave-Ocean-Ice Coupled Modeling System

DTIC Science & Technology

2015-09-30

MIZ using WW3 (3 frequency bins, ice retreat in August and ice advance in October); Blue (solid): Based on observations near Antarctica by Meylan...1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Wave- Ice interaction in the Marginal Ice Zone: Toward a...Wave-Ocean- Ice Coupled Modeling System W. E. Rogers Naval Research Laboratory, Code 7322 Stennis Space Center, MS 39529 phone: (228) 688-4727

Wave Climate and Wave Mixing in the Marginal Ice Zones of Arctic Seas, Observations and Modelling

DTIC Science & Technology

2014-09-30

At the same time, the PIs participate in Australian efforts of developing wave-ocean- ice coupled models for Antarctica . Specific new physics modules...Wave Mixing in the Marginal Ice Zones of Arctic Seas, Observations and Modelling Alexander V. Babanin Swinburne University of Technology, PO Box...operational forecast. Altimeter climatology and the wave models will be used to study the current and future wind/wave and ice trends. APPROACH

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Non-Hodgkin Lymphoma

ClinicalTrials.gov

2018-03-20

B-Cell Prolymphocytic Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Lymphoplasmacytic Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Diffuse Large B-Cell Lymphoma; Refractory Follicular Lymphoma; Refractory Lymphoplasmacytic Lymphoma; Refractory Mantle Cell Lymphoma; Refractory Marginal Zone Lymphoma; Refractory Non-Hodgkin Lymphoma; Refractory Small Lymphocytic Lymphoma; Richter Syndrome

Ocean-ice interaction in the marginal ice zone

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Peng, Chich Y.

1994-01-01

Ocean ice interaction processes in the Marginal Ice Zone (MIZ) by wind, waves, and mesoscale features, such as upwelling and eddies, are studied using ERS-1 Synthetic Aperture Radar (SAR) images and ocean ice interaction model. A sequence of SAR images of the Chukchi Sea MIZ with three days interval are studied for ice edge advance/retreat. Simultaneous current measurements from the northeast Chukchi Sea as well as the Barrow wind record are used to interpret the MIZ dynamics.

17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With Relapsed or Refractory Hematologic Cancer

ClinicalTrials.gov

2013-06-03

Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin.

PubMed

Roggero, E; Zucca, E; Mainetti, C; Bertoni, F; Valsangiacomo, C; Pedrinis, E; Borisch, B; Piffaretti, J C; Cavalli, F; Isaacson, P G

2000-02-01

Primary cutaneous B-cell lymphomas have been associated with Borrelia burgdorferi, the spirochete responsible for Lyme disease. Recently, cutaneous marginal zone B-cell lymphoma has been proposed as a distinct clinical-pathological entity. We report a case of primary cutaneous marginal zone lymphoma, associated with B burgdorferi infection. Polymerase chain reaction (PCR) amplification of the third complementarity determining region (CDR3) of the immunoglobulin heavy chain gene showed the presence of a monoclonal lymphoproliferation, therefore strengthening the histological diagnosis of a malignant process. B burgdorfer-specific hbb gene sequences were detected by PCR in the lymphoma tissue at diagnosis but not after antibiotic treatment. A nearly complete clinical and histological regression was observed after B burgdorferi eradication, with immunohistochemistry studies showing disappearance of plasma cell differentiation and a marked decline in the number of CD3+ T cells and Ki-67+ cells. Our case confirms the link between B burgdorferi and some cutaneous lymphomas. The disappearance of the microorganism accompanied by the unequivocal decrease of most indicators of active T- and B-cell immune response strongly supported a pathogenetic role for B burgdorferi in sustaining an antigen-driven development and growth of this cutaneous marginal zone lymphoma. Antibiotic therapy (analogous to Helicobacter pylori infection in gastric MALT lymphoma) might be helpful with the aim of averting or at least deferring the indication for more aggressive treatment.

Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8+ T-cell priming and viral control

PubMed Central

Duhan, Vikas; Khairnar, Vishal; Friedrich, Sarah-Kim; Zhou, Fan; Gassa, Asmae; Honke, Nadine; Shaabani, Namir; Gailus, Nicole; Botezatu, Lacramioara; Khandanpour, Cyrus; Dittmer, Ulf; Häussinger, Dieter; Recher, Mike; Hardt, Cornelia; Lang, Philipp A.; Lang, Karl S.

2016-01-01

Clinically used human vaccination aims to induce specific antibodies that can guarantee long-term protection against a pathogen. The reasons that other immune components often fail to induce protective immunity are still debated. Recently we found that enforced viral replication in secondary lymphoid organs is essential for immune activation. In this study we used the lymphocytic choriomeningitis virus (LCMV) to determine whether enforced virus replication occurs in the presence of virus-specific antibodies or virus-specific CD8+ T cells. We found that after systemic recall infection with LCMV-WE the presence of virus-specific antibodies allowed intracellular replication of virus in the marginal zone of spleen. In contrast, specific antibodies limited viral replication in liver, lung, and kidney. Upon recall infection with the persistent virus strain LCMV-Docile, viral replication in spleen was essential for the priming of CD8+ T cells and for viral control. In contrast to specific antibodies, memory CD8+ T cells inhibited viral replication in marginal zone but failed to protect mice from persistent viral infection. We conclude that virus-specific antibodies limit viral infection in peripheral organs but still allow replication of LCMV in the marginal zone, a mechanism that allows immune boosting during recall infection and thereby guarantees control of persistent virus. PMID:26805453

Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma

ClinicalTrials.gov

2015-05-06

Adult Nasal Type Extranodal NK/T-cell Lymphoma; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I AIDS-related Lymphoma; Stage II AIDS-related Lymphoma; Stage III AIDS-related Lymphoma; Stage IV AIDS-related Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma

ClinicalTrials.gov

2016-01-07

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

A preliminary report on the geology of the Dennison-Bunn uranium claim, Sandoval County, New Mexico

USGS Publications Warehouse

Ridgley, Jennie L.

1978-01-01

Uranium at the Dennison-Bunn claim, south of Cuba, N. Mex., along the east margin of the San Juan Basin, occurs in unoxidized gray, fluvial channel sandstone of the Westwater Canyon Member of the Upper Jurassic Morrison Formation. The uranium-bearing sandstone is bounded on the north and south by a variable zone of buff and orange sandstone. Within the mineralized zone, the uranium has been remobilized and reconcentrated along the margins of numerous smaller tongues of oxidized rock in a configuration similar to that found in roll-type uranium deposits. In cross section, these small-scale features are zoned; they have an inner, pale orange, oxidized core, a mineralized redox rim cemented with hematite(?), and an outer-shell of -gray, slightly to moderately mineralized rock. The uranium content in the mineralized rock ranges from 0.001 to 0.07 percent U3O8. The uranium, at this locality, is believed to have originated within the Westwater Canyon Member or to have been derived from the overlying Brushy Basin Member. Based on observed outcrop relations, two hypotheses are proposed for explaining the origin of the occurrence. Briefly these hypotheses are: (1) the mineralized zone represents the remnant of an original roll-type uranium deposit, formed during early Eocene time, which has undergone subsequent oxidation with remobilization and redeposition of uranium around the margins of smaller tongues of oxidized rock; and (2) the mineralized zone represents the remnant of an original tabular deposit which has undergone subsequent oxidation with remobilization and redeposition of uranium around the margins of smaller tongues of oxidized rock.

Seismic investigation of an ocean-continent transition zone in the northern South China Sea

NASA Astrophysics Data System (ADS)

Zhu, J.; Qiu, X.; Xu, H.; Zhan, W.; Sun, Z.

2011-12-01

Rifted continental margins and basins are mainly formed by the lithospheric extension. Thined lithosphere of passive continental margins results in decompression melt of magma and created oceanic crust and thined ocean-continent transition (OCT) zone. Two refraction profiles used ocean bottom seismometers deployed in the broad continental shelf and three multi-channel seismic reflection lines in the northern South China Sea, acquired by the ship "Shiyan 2" of the South China Sea Institute of Oceanology, Chinese Academy of Sciences in 2010, are processed and interpreted in this study. Seismic reflection lines cut through the Dongsha rise, Zhu-1 and Zhu-2 depression within a Tertiary basin, Pear River Mouth basin (called as Zhujiangkou basin). These tectonic features are clear imaged in the seismic reflection records. Numerous normal faults, cutted through the basement and related to the stretch of the northern South China Sea margin, are imaged and interpreted. Reflection characteristics of the ocean-continent transition (OCT) zone are summaried and outlined. The COT zone is mainly divided into the northern syn-rift subsidence zone, central volcano or buried volcano uplift zone and tilt faulted block near the South Chia Sea basin. Compared to the previous seismic reflection data and refraction velocity models, the segmentation range of the OCT zone is outlined, from width of about 225 km in the northeastern South China Sea , of 160 km in the central to of 110 km in the north-central South China Sea. Based on the epicenter distribution of sporadic and large than 6 magnitude earthquakes, it suggests the OCT zone in the northern South China Sea at present is still an active seismic zone.

Wave propagation in the marginal ice zone - Model predictions and comparisons with buoy and synthetic aperture radar data

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Holt, Benjamin; Vachon, Paris W.

1991-01-01

Ocean wave dispersion relation and viscous attenuation by a sea ice cover are studied for waves propagating into the marginal ice zone (MIZ). The Labrador ice margin experiment (LIMEX), conducted on the MIZ off the east coast of Newfoundland, Canada in March 1987, provided aircraft SAR imagery, ice property and wave buoy data. Wave energy attenuation rates are estimated from SAR data and the ice motion package data that were deployed at the ice edge and into the ice pack, and compared with a model. It is shown that the model data comparisons are quite good for the ice conditions observed during LIMEX 1987.

75 FR 49912 - Foreign-Trade Zone 40-Cleveland, OH; Site Renumbering Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

...)--Cleveland Business Park, Cleveland; Site 3 (450 acres)--Burke Lakefront Airport, 1501 North Marginal Road..., Glenwillow; Site 5 (17 acres)--within the Collinwood Industrial Park, South Waterloo (South Marginal) Road...

Tanespimycin and Bortezomib in Treating Patients With Advanced Solid Tumors or Lymphomas

ClinicalTrials.gov

2014-02-21

Adult Grade III Lymphomatoid Granulomatosis; AIDS-related Peripheral/Systemic Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

Florida: A Jurassic transform plate boundary

USGS Publications Warehouse

Klitgord, Kim D.; Popenoe, Peter; Schouten, Hans

1984-01-01

Magnetic, gravity, seismic, and deep drill hole data integrated with plate tectonic reconstructions substantiate the existence of a transform plate boundary across southern Florida during the Jurassic. On the basis of this integrated suite of data the pre-Cretaceous Florida-Bahamas region can be divided into the pre-Jurassic North American plate, Jurassic marginal rift basins, and a broad Jurassic transform zone including stranded blocks of pre-Mesozoic continental crust. Major tectonic units include the Suwannee basin in northern Florida containing Paleozoic sedimentary rocks, a central Florida basement complex of Paleozoic age crystalline rock, the west Florida platform composed of stranded blocks of continental crust, the south Georgia rift containing Triassic sedimentary rocks which overlie block-faulted Suwannee basin sedimentary rocks, the Late Triassic-Jurassic age Apalachicola rift basin, and the Jurassic age south Florida, Bahamas, and Blake Plateau marginal rift basins. The major tectonic units are bounded by basement hinge zones and fracture zones (FZ). The basement hinge zone represents the block-faulted edge of the North American plate, separating Paleozoic and older crustal rocks from Jurassic rifted crust beneath the marginal basins. Fracture zones separate Mesozoic marginal sedimentary basins and include the Blake Spur FZ, Jacksonville FZ, Bahamas FZ, and Cuba FZ, bounding the Blake Plateau, Bahamas, south Florida, and southeastern Gulf of Mexico basins. The Bahamas FZ is the most important of all these features because its northwest extension coincides with the Gulf basin marginal fault zone, forming the southern edge of the North American plate during the Jurassic. The limited space between the North American and the South American/African plates requires that the Jurassic transform zone, connecting the Central Atlantic and the Gulf of Mexico spreading systems, was located between the Bahamas and Cuba FZ's in the region of southern Florida. Our plate reconstructions combined with chronostratigraphic and lithostratigraphic information for the Gulf of Mexico, southern Florida, and the Bahamas indicate that the gulf was sealed off from the Atlantic waters until Callovian time by an elevated Florida-Bahamas region. Restricted influx of waters started in Callovian as a plate reorganization, and increased plate separation between North America and South America/Africa produced waterways into the Gulf of Mexico from the Pacific and possibly from the Atlantic.

Shyok Suture Zone, N Pakistan: late Mesozoic Tertiary evolution of a critical suture separating the oceanic Ladakh Arc from the Asian continental margin

NASA Astrophysics Data System (ADS)

Robertson, Alastair H. F.; Collins, Alan S.

2002-02-01

The Shyok Suture Zone (Northern Suture) of North Pakistan is an important Cretaceous-Tertiary suture separating the Asian continent (Karakoram) from the Cretaceous Kohistan-Ladakh oceanic arc to the south. In previously published interpretations, the Shyok Suture Zone marks either the site of subduction of a wide Tethyan ocean, or represents an Early Cretaceous intra-continental marginal basin along the southern margin of Asia. To shed light on alternative hypotheses, a sedimentological, structural and igneous geochemical study was made of a well-exposed traverse in North Pakistan, in the Skardu area (Baltistan). To the south of the Shyok Suture Zone in this area is the Ladakh Arc and its Late Cretaceous, mainly volcanogenic, sedimentary cover (Burje-La Formation). The Shyok Suture Zone extends northwards (ca. 30 km) to the late Tertiary Main Karakoram Thrust that transported Asian, mainly high-grade metamorphic rocks southwards over the suture zone. The Shyok Suture Zone is dominated by four contrasting units separated by thrusts, as follows: (1). The lowermost, Askore amphibolite, is mainly amphibolite facies meta-basites and turbiditic meta-sediments interpreted as early marginal basin rift products, or trapped Tethyan oceanic crust, metamorphosed during later arc rifting. (2). The overlying Pakora Formation is a very thick (ca. 7 km in outcrop) succession of greenschist facies volcaniclastic sandstones, redeposited limestones and subordinate basaltic-andesitic extrusives and flow breccias of at least partly Early Cretaceous age. The Pakora Formation lacks terrigenous continental detritus and is interpreted as a proximal base-of-slope apron related to rifting of the oceanic Ladakh Arc; (3). The Tectonic Melange (<300 m thick) includes serpentinised ultramafic rocks, near mid-ocean ridge-type volcanics and recrystallised radiolarian cherts, interpreted as accreted oceanic crust. (4). The Bauma-Harel Group (structurally highest) is a thick succession (several km) of Ordovician and Carboniferous to Permian-Triassic, low-grade, mixed carbonate/siliciclastic sedimentary rocks that accumulated on the south-Asian continental margin. A structurally associated turbiditic slope/basinal succession records rifting of the Karakoram continent (part of Mega-Lhasa) from Gondwana. Red clastics of inferred fluvial origin ('molasse') unconformably overlie the Late Palaeozoic-Triassic succession and are also intersliced with other units in the suture zone. Reconnaissance further east (north of the Shyok River) indicates the presence of redeposited volcaniclastic sediments and thick acid tuffs, derived from nearby volcanic centres, presumed to lie within the Ladakh Arc. In addition, comparison with Lower Cretaceous clastic sediments (Maium Unit) within the Northern Suture Zone, west of the Nanga Parbat syntaxis (Hunza River) reveals notable differences, including the presence of terrigenous quartz-rich conglomerates, serpentinite debris-flow deposits and a contrasting structural history. The Shyok Suture Zone in the Skardu area is interpreted to preserve the remnants of a rifted oceanic back-arc basin and components of the Asian continental margin. In the west (Hunza River), a mixed volcanogenic and terrigenous succession (Maium Unit) is interpreted to record syn-deformational infilling of a remnant back-arc basin/foreland basin prior to suturing of the Kohistan Arc with Asia (75-90 Ma).

Radar Remote Sensing of Ice and Sea State and Air-Sea Interaction in the Marginal Ice Zone

DTIC Science & Technology

2014-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Radar Remote Sensing of Ice and Sea State and Air-Sea...Interaction in the Marginal Ice Zone Hans C. Graber RSMAS – Department of Ocean Sciences Center for Southeastern Tropical Advanced Remote Sensing...scattering and attenuation process of ocean waves interacting with ice . A nautical X-band radar on a vessel dedicated to science would be used to follow the

The Regulation of Polysaccharide Specific Humoral Immune Response Against Intact Streptococcus Pneumoniae

DTIC Science & Technology

2008-06-19

Attanavanich, K . and J. F. Kearney (2004). "Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells." J Immunol 172(2): 803-11...resistance in B cells." J Immunol 157(7): 2749-53. Fujita, T., K . Inoue, et al. (1994). "Fungal metabolites. Part 11. A potent immunosuppressive activity...Girkontaite, I., K . Missy, et al. (2001). "Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses." Nat

Hanging canyons of Haida Gwaii, British Columbia, Canada: Fault-control on submarine canyon geomorphology along active continental margins

NASA Astrophysics Data System (ADS)

Harris, Peter T.; Barrie, J. Vaughn; Conway, Kim W.; Greene, H. Gary

2014-06-01

Faulting commonly influences the geomorphology of submarine canyons that occur on active continental margins. Here, we examine the geomorphology of canyons located on the continental margin off Haida Gwaii, British Columbia, that are truncated on the mid-slope (1200-1400 m water depth) by the Queen Charlotte Fault Zone (QCFZ). The QCFZ is an oblique strike-slip fault zone that has rates of lateral motion of around 50-60 mm/yr and a small convergent component equal to about 3 mm/yr. Slow subduction along the Cascadia Subduction Zone has accreted a prism of marine sediment against the lower slope (1500-3500 m water depth), forming the Queen Charlotte Terrace, which blocks the mouths of submarine canyons formed on the upper slope (200-1400 m water depth). Consequently, canyons along this margin are short (4-8 km in length), closely spaced (around 800 m), and terminate uniformly along the 1400 m isobath, coinciding with the primary fault trend of the QCFZ. Vertical displacement along the fault has resulted in hanging canyons occurring locally. The Haida Gwaii canyons are compared and contrasted with the Sur Canyon system, located to the south of Monterey Bay, California, on a transform margin, which is not blocked by any accretionary prism, and where canyons thus extend to 4000 m depth, across the full breadth of the slope.

Ductile extension of syn-magmatic lower crusts, with application to volcanic passive margins: the Ivrea Zone (Southern Alps, Italy)

NASA Astrophysics Data System (ADS)

Bidault, Marie; Geoffroy, Laurent; Arbaret, Laurent; Aubourg, Charles

2017-04-01

Deep seismic reflection profiles of present-day volcanic passive margins often show a 2-layered lower crust, from top to bottom: an apparently ductile 12 km-thick middle-lower layer (LC1) of strong folded reflectors and a 4 km-thick supra-Moho layer (LC2) of horizontal and parallel reflectors. Those layers appear to be structurally disconnected and to develop at the early stages of margins evolution. A magmatic origin has been suggested by several studies to explain those strong reflectors, favoring mafic sills intrusion hypothesis. Overlying mafic and acidic extrusives (Seaward Dipping Reflectors sequences) are bounded by continentward-dipping detachment faults rooting in, and co-structurated with, the ductile part of the lower crust (LC1). Consequently the syn-rift to post-rift evolution of volcanic passive margins (and passive margins in general) largely depends on the nature and the properties of the lower crust, yet poorly understood. We propose to investigate the properties and rheology of a magma-injected extensional lower crust with a field analogue, the Ivrea Zone (Southern Alps, Italy). The Ivrea Zone displays a complete back-thrusted section of a Variscan continental lower crust that first underwent gravitational collapse, and then lithospheric extension. This Late Paleozoic extension was apparently associated with the continuous intrusion of a large volume of mafic to acid magma. Both the magma timing and volume, and the structure of the Ivrea lower crust suggest that this section represents an adequate analogue of a syn-magmatic in-extension mafic rift zone which aborted at the end of the Permian. Notably, we may recognize the 2 layers LC1 and LC2. From a number of tectonic observations, we reconstitute the whole tectonic history of the area, focusing on the strain field evolution with time, in connection with mafic magma injection. We compare those results with available data from extensional mafic lower crusts at rifts and margins.

How the structural architecture of the Eurasian continental margin affects the structure, seismicity, and topography of the south central Taiwan fold-and-thrust belt

NASA Astrophysics Data System (ADS)

Brown, Dennis; Alvarez-Marron, Joaquina; Biete, Cristina; Kuo-Chen, Hao; Camanni, Giovanni; Ho, Chun-Wei

2017-07-01

Studies of mountain belts worldwide show that along-strike changes are common in their foreland fold-and-thrust belts. These are typically caused by processes related to fault reactivation and/or fault focusing along changes in sedimentary sequences. The study of active orogens, like Taiwan, can also provide insights into how these processes influence transient features such as seismicity and topography. In this paper, we trace regional-scale features from the Eurasian continental margin in the Taiwan Strait into the south central Taiwan fold-and-thrust belt. We then present newly mapped surface geology, P wave velocity maps and sections, seismicity, and topography data to test the hypothesis of whether or not these regional-scale features of the margin are contributing to along-strike changes in structural style, and the distribution of seismicity and topography in this part of the Taiwan fold-and-thrust belt. These data show that the most important along-strike change takes place at the eastward prolongation of the upper part of the margin necking zone, where there is a causal link between fault reactivation, involvement of basement in the thrusting, concentration of seismicity, and the formation of high topography. On the area correlated with the necking zone, the strike-slip reactivation of east northeast striking extensional faults is causing sigmoidal offset of structures and topography along two main zones. Here basement is not involved in the thrusting; there is weak focusing of seismicity and localized development of topography. We also show that there are important differences in structure, seismicity, and topography between the margin shelf and its necking zone.

Redox Effects on Organic Matter Storage in Coastal Sediments During the Holocene: A Biomarker/Proxy Perspective

NASA Astrophysics Data System (ADS)

Bianchi, Thomas S.; Schreiner, Kathryn M.; Smith, Richard W.; Burdige, David J.; Woodard, Stella; Conley, Daniel J.

2016-06-01

Coastal margins play a significant role in the burial of organic matter (OM) on Earth. These margins vary considerably with respect to their efficiency in OM burial and to the amounts and periodicity of their OM delivery, depending in large part on whether they are passive or active margins. In the context of global warming, these coastal regions are expected to experience higher water temperatures, changes in riverine inputs of OM, and sea level rise. Low-oxygen conditions continue to expand around the globe in estuarine regions (i.e., hypoxic zones) and shelf regions (i.e., oxygen minimum zones), which will impact the amounts and sources of OM stored in these regions. In this review, we explore how these changes are impacting the storage of OM and the preservation of sedimentary biomarkers, used as proxies to reconstruct environmental change, in coastal margins.

Dasatinib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Did Not Respond to Imatinib Mesylate

ClinicalTrials.gov

2013-02-04

Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Childhood Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Meningeal Chronic Myelogenous Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Relapsing Chronic Myelogenous Leukemia; Unspecified Childhood Solid Tumor, Protocol Specific

BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia

ClinicalTrials.gov

2013-01-22

Adult Acute Promyelocytic Leukemia (M3); Blastic Phase Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Relapsing Chronic Myelogenous Leukemia

CD4-Negative Variant of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm With a Novel PBRM1 Mutation in an 11-Year-Old Girl.

PubMed

Yigit, Nuri; Suarez, Luisa Fernanda; Roth, Lisa Giulino; Orazi, Attilio; Tam, Wayne

2017-05-01

We report a rare case of CD4- cutaneous blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a novel PBRM1 mutation. An 11-year-old girl presented with an enlarged mass on her left arm and underwent an incisional biopsy. Histopathologic examination and immunohistochemistry studies showed a monotonous proliferation of blasts that were CD4-, CD56+, and CD123+. There was no evidence of leukemic dissemination. Next-generation sequencing detected PBRM1 and CIC gene abnormalities. We confirmed and validated a novel PBRM1 mutation by conventional polymerase chain reaction and Sanger sequencing. CD4- variant of BPDCN may be mistaken for myeloid sarcoma or extramedullary lymphoblastic leukemia/lymphoma because of their overlapping morphologic and immunophenotypic features; thus, a careful clinicopathologic evaluation is essential to reach the correct diagnosis. PBRM1 mutation seems to be a driver event in this case. Our study underscores the importance of alterations in chromatin remodeling in the pathogenesis of BPDCN. © American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Childhood nodal marginal zone lymphoma with unusual clinicopathologic and cytogenetic features for the pediatric variant: a case report.

PubMed

Aqil, Barina; Merritt, Brian Y; Elghetany, M Tarek; Kamdar, Kala Y; Lu, Xinyan Y; Curry, Choladda V

2015-01-01

Nodal marginal zone lymphoma (NMZL) is a B-cell lymphoma that shares morphologic and immunophenotypic features with extranodal and splenic marginal zone lymphomas but lacks extranodal or splenic involvement at presentation. NMZL occurs mostly in adults with no sex predilection, at advanced stage (III or IV), with frequent relapses and a high incidence of tumoral genetic abnormalities including trisomies 3 and 18 and gain of 7q. Pediatric NMZL, however, is a rare but distinct variant of NMZL with characteristic features including male predominance, asymptomatic and localized (stage I) disease, low relapse rates with excellent outcomes, and a lower incidence of essentially similar genetic aberrations compared to adult NMZL. Here we describe a unique case of childhood NMZL with unusual clinicopathologic features for the pediatric variant including generalized lymphadenopathy, high-stage disease with persistence after therapy, unusual immunophenotype (CD5, CD23, and BCL6 positive), and unique chromosomal abnormalities including monosomy 20 and add(10)(p11.2).

MicroRNA-150 Is up-regulated in extranodal marginal zone lymphoma of MALT type.

PubMed

Gebauer, Niklas; Kuba, Johannes; Senft, Andrea; Schillert, Arne; Bernard, Veronica; Thorns, Christoph

2014-01-01

The mechanisms promoting malignant transformation from chronic Helicobacter pylori-gastritis to gastric extranodal marginal zone lymphoma (MALT lymphoma) are insufficiently characterized. This follow-up study aimed to validate candidate microRNAs (miRs) in the process of neoplastic transformation. MicroRNA expression signatures (n=20) were generated for a total of 60 cases of gastric lesions ranging from Wotherspoon 0-5 employing a quantitative real-time polymerase chain reaction (PCR) approach. Morphological and immunohistochemical characterization of the cohort was supplemented by PCR-based immunoglobulin heavy chain recombination studies. Quantitative expression of miR-150, miR-142.3p, miR-375 and miR-494 was significantly de-regulated in samples from MALT lymphoma compared to those from gastritis. The previously reported up-regulation of miR-150 in marginal zone lymphoma of MALT type was verified in an independent cohort of lymphoma samples employing a modified methodology. This further substantiates the role of miR-150 as a potential oncomiR in MALT lymphoma.

Long-term outcome for patients with early stage marginal zone lymphoma and mantle cell lymphoma.

PubMed

Barzenje, Dlawer Abdulla; Holte, Harald; Fosså, Alexander; Ghanima, Waleed; Liestøl, Knut; Delabie, Jan; Kolstad, Arne

2017-03-01

In this study with prolonged follow up, we compared clinical outcome, including cause of death and incidence of second cancer, for patients with early stage extranodal marginal zone lymphoma (EMZL, 49 patients), nodal marginal zone lymphoma (NMZL, nine patients) and mantle cell lymphoma (MCL, 42 patients) with emphasis on potential benefit of radiotherapy. Radiotherapy was given to 40 patients with EMZL (nine had surgery only) and all NMZL patients. MCL patients received radiotherapy (17 patients), chemotherapy followed by radiotherapy (13 patients) or chemotherapy alone (12 patients). Compared to a matched control population no increased risk of second cancer or cardiovascular disease was observed. Radiotherapy alone was effective in EMZL and NMZL with low-relapse rates (20% and 33%) and a 10-year overall survival of 78% and 56%, respectively. High-relapse rate and inferior OS in MCL underline the need for extended staging with endoscopy and PET/CT and possibly for novel strategies.

Extranodal marginal zone B cell lymphoma of the orbit in a patient with sarcoidosis: a case report.

PubMed

Richards, Nikisha Q; Kidwell, Earl D R; Ramadan, Ali M; Naab, Tammey J

2014-10-20

To describe a case of extranodal marginal zone B-cell lymphoma (EMZL) "mucosa associated lymphoid tissue (MALT)" of the orbit that presented with stage IV disease in a patient with sarcoidosis. Clinicopathologic case report. Biopsies of the lesion were performed in the operating room and the samples were submitted for pathology processing. Pathology analysis identified the lesion as an extranodal marginal zone B-cell lymphoma "mucosa associated lymphoid tissue (MALT)" via flow cytometry, histopathology, cytogenetics, and immunohistochemical staining and fluorescent in situ hybridization (FISH). The institutional review board of Howard University Hospital waived the need for IRB approval for this intraoperative finding. A 70-year-old Black woman with biopsy-proven sarcoidosis presented complaining of foreign body sensation, redness, swelling of her left upper eyelid and tearing. The patient was found to have an orbital lymphoproliferative malignancy. It is still unclear if the presence of immunosuppression or an autoimmune disease increases the risk of lymphoproliferative malignancies {6}. Malignancy should always be suspected and investigated.

Reconstruction of the East Africa and Antarctica continental margins

NASA Astrophysics Data System (ADS)

Nguyen, Luan C.; Hall, Stuart A.; Bird, Dale E.; Ball, Philip J.

2016-06-01

The Early Jurassic separation of Antarctica from Africa plays an important role in our understanding of the dispersal of Gondwana and Pangea. Previous reconstruction models contain overlaps and gaps in the restored margins that reflect difficulties in accurately delineating the continent-ocean-boundary (COB) and determining the amount and distribution of extended continental crust. This study focuses on the evolution of the African margin adjacent to the Mozambique Basin and the conjugate Antarctic margin near the Riiser-Larsen Sea. Satellite-derived gravity data have been used to trace the orientations and landward limits of fracture zones. A 3-D gravity inversion has produced a crustal thickness model that reliably quantifies the extent and amount of stretched crust. Crustal thicknesses together with fracture zone terminations reveal COBs that are significantly closer to the African and Antarctic coasts than previously recognized. Correlation of fracture zone azimuths and identified COBs suggests Antarctica began drifting away from Africa at approximately 171 Ma in a roughly SSE direction. An areal-balancing method has been used to restore the crust to a uniform prerift thickness so as to perform a nonrigid reconstruction for both nonvolcanic and volcanic margins. Both margins reveal a trend of increasing extension from east to west. Our results suggest Africa underwent extension of 60-120 km, while Antarctic crust was stretched by 105-180 km. Various models tested to determine the direction of extension during rifting suggest that Antarctica moved away from Africa in a WNW-ESE direction during the period between 184 and 171 Ma prior to the onset of seafloor spreading.

Investigating Variations in Rifting Style Along the Southern Margin of Flemish Cap, Offshore Newfoundland: Results from the Erable Multichannel Seismic Reflection Experiment

NASA Astrophysics Data System (ADS)

Welford, J.; Smith, J.; Hall, J.; Deemer, S.; Srivastava, S.; Sibuet, J.

2009-05-01

In 1992, the Erable project was undertaken by the Geological Survey of Canada and Ifremer to acquire multiple 2-D multichannel seismic reflection profiles in the Newfoundland Basin and along the margins of Flemish Cap. We present four multichannel seismic reflection profiles from the project collected over the southern margin of Flemish Cap and extending into the Newfoundland Basin. These profiles are between and sub- parallel to lines 1 and 2 from the 2000 SCREECH seismic experiment and provide more comprehensive data coverage over the region. We combine these data with the SCREECH seismic profiles, two ODP drill sites, and other geophysical data to map distinct zones of continental, transitional, and oceanic crust in this region. Just as has been evidenced from the mapped crustal boundaries on their conjugate Galicia Bank and Iberian margins, the Flemish Cap and Newfoundland margins show significant along-margin variability in terms of rifting structures and styles. This along-margin variability is superimposed on the overall asymmetry of the conjugate pairs highlighting the complexity of the margins and the importance of considering three- dimensional influences on rifting evolution. In particular, the hypothesized clockwise rotation and southeastward motion of Flemish Cap and the transfer zones that would have accommodated such movement appear to have affected the distribution of extension along the margins as rifting propagated northward. Meanwhile, activity at the North Atlantic triple junction immediately to the east of Flemish Cap may have initiated slow seafloor spreading while rifting was still active to the south as evidenced along the nearby Erable profiles. While simple two-dimensional rifting models may be appropriate for interpreting individual seismic profiles, three-dimensional rifting models are clearly needed to adequately explain the evolution of Flemish Cap and Galicia Bank relative to the margins to the south. These rifting models must incorporate the influences of microplate reorganization on both sides of the North Atlantic as well as transfer zones and the North Atlantic triple junction.

Crustal structure and inferred extension mode in the northern margin of the South China Sea

NASA Astrophysics Data System (ADS)

Gao, J.; Wu, S.; McIntosh, K. D.; Mi, L.; Spence, G.

2016-12-01

Combining multi-channel seismic reflection and satellite gravity data, this study has investigated the crustal structure and magmatic activities of the northern South China Sea (SCS) margin. Results show that a broad continent-ocean transition zone (COT) with more than 140 km wide is characterized by extensive igneous intrusion/extrusion and hyper-extended continental crust in the northeastern SCS margin, a broader COT with 220-265 km wide is characterized by crustal thinning, rift depression, structural highs with igneous rock and perhaps a volcanic zone or a zone of tilted fault blocks at the distal edge in the mid-northern SCS margin, and a narrow COT with 65 km wide bounded seawards by a volcanic buried seamount is characterized by extremely hyper-extended continental crust in the northwestern SCS margin, where the remnant crust with less than 3 km thick is bounded by basin-bounding faults corresponding to an aborted rift below the Xisha Trough with a sub-parallel fossil ridge in the adjacent Northwest Sub-basin. Results from gravity modeling and seismic refraction data show that a high velocity layer (HVL) is present in the outer shelf and slope below extended continental crust in the eastern portion of the northern SCS margin and is thickest (up to 10 km) in the Dongsha Uplift where the HVL gradually thins to east and west below the lower slope and finally terminates at the Manila Trench and Baiyun sag of the Pearl River Mouth Basin. The magmatic intrusions/extrusions and HVL may be related to partial melting caused by decompression of passive, upwelling asthenosphere which resulted primarily in post-rifting underplating and magmatic emplacement or modification of the crust. The northern SCS margin is closer to those of the magma-poor margins than those of volcanic margins, but the aborted rift near the northwestern continental margin shows that there may be no obvious detachment fault like that in the Iberia-Newfoundland type margin. The symmetric aborted rift, broad hyper-extended continental crust, locally distributed HVL, and hotter mantle materials indicate that continental crust underwent stretching phase (pure-shear deformation), thinning phase and breakup followed by onset of seafloor spreading and the mantle-lithosphere may break up before crustal-necking in the northern South China Sea margin.

Tectonic evolution of the Qumran Basin from high-resolution 3.5-kHz seismic profiles and its implication for the evolution of the northern Dead Sea Basin

NASA Astrophysics Data System (ADS)

Lubberts, Ronald K.; Ben-Avraham, Zvi

2002-02-01

The Dead Sea Basin is a morphotectonic depression along the Dead Sea Transform. Its structure can be described as a deep rhomb-graben (pull-apart) flanked by two block-faulted marginal zones. We have studied the recent tectonic structure of the northwestern margin of the Dead Sea Basin in the area where the northern strike-slip master fault enters the basin and approaches the western marginal zone (Western Boundary Fault). For this purpose, we have analyzed 3.5-kHz seismic reflection profiles obtained from the northwestern corner of the Dead Sea. The seismic profiles give insight into the recent tectonic deformation of the northwestern margin of the Dead Sea Basin. A series of 11 seismic profiles are presented and described. Although several deformation features can be explained in terms of gravity tectonics, it is suggested that the occurrence of strike-slip in this part of the Dead Sea Basin is most likely. Seismic sections reveal a narrow zone of intensely deformed strata. This zone gradually merges into a zone marked by a newly discovered tectonic depression, the Qumran Basin. It is speculated that both structural zones originate from strike-slip along right-bending faults that splay-off from the Jordan Fault, the strike-slip master fault that delimits the active Dead Sea rhomb-graben on the west. Fault interaction between the strike-slip master fault and the normal faults bounding the transform valley seems the most plausible explanation for the origin of the right-bending splays. We suggest that the observed southward widening of the Dead Sea Basin possibly results from the successive formation of secondary right-bending splays to the north, as the active depocenter of the Dead Sea Basin migrates northward with time.

Fault zone structure and seismic reflection characteristics in zones of slow slip and tsunami earthquakes

NASA Astrophysics Data System (ADS)

Bell, Rebecca; Henrys, Stuart; Sutherland, Rupert; Barker, Daniel; Wallace, Laura; Holden, Caroline; Power, William; Wang, Xiaoming; Morgan, Joanna; Warner, Michael; Downes, Gaye

2015-04-01

Over the last couple of decades we have learned that a whole spectrum of different fault slip behaviour takes place on subduction megathrust faults from stick-slip earthquakes to slow slip and stable sliding. Geophysical data, including seismic reflection data, can be used to characterise margins and fault zones that undergo different modes of slip. In this presentation we will focus on the Hikurangi margin, New Zealand, which exhibits marked along-strike changes in seismic behaviour and margin characteristics. Campaign and continuous GPS measurements reveal deep interseismic coupling and deep slow slip events (~30-60 km) at the southern Hikurangi margin. The northern margin, in contrast, experiences aseismic slip and shallow (<10-15 km) slow slip events (SSE) every 18-24 months with equivalent moment magnitudes of Mw 6.5-6.8. Updip of the SSE region two unusual megathrust earthquakes occurred in March and May 1947 with characteristics typical of tsunami earthquakes. The Hikurangi margin is therefore an excellent natural laboratory to study differential fault slip behaviour. Using 2D seismic reflection, magnetic anomaly and geodetic data we observe in the source areas of the 1947 tsunami earthquakes i) low amplitude interface reflectivity, ii) shallower interface relief, iii) bathymetric ridges, iv) magnetic anomaly highs and in the case of the March 1947 earthquake v) stronger geodetic coupling. We suggest that this is due to the subduction of seamounts, similar in dimensions to seamounts observed on the incoming Pacific plate, to depths of <10 km. We propose a source model for the 1947 tsunami earthquakes based on geophysical data and find that extremely low rupture velocities (c. 300 m/s) are required to model the observed large tsunami run-up heights (Bell et al. 2014, EPSL). Our study suggests that subducted topography can cause the nucleation of moderate earthquakes with complex, low velocity rupture scenarios that enhance tsunami waves, and the role of subducted rough topography in seismic hazard should not be under-estimated. 2D seismic reflection data along the northern Hikurangi margin also image thick (c. 2 km) high-amplitude reflectivity zones (HRZ) coinciding broadly with the source areas of shallow SSEs. The HRZ may be the result of high-fluid content within subduction sediments, suggesting fluids may exert an important control on the generation of SSEs by reducing effective stress (Bell et al. 2010, GJI). However, this hypothesis remains untested. In this presentation, using synthetic models, we will discuss planned future applications of an advanced seismic imaging technique called Full-waveform inversion, integrated with drilling, at subduction margins like Hikurangi to recover fault physical properties at high-resolution in 3D to examine the properties of heterogeneous fault zones.

Retrogressive hydration of calc-silicate xenoliths in the eastern Bushveld complex: evidence for late magmatic fluid movement

NASA Astrophysics Data System (ADS)

Wallmach, T.; Hatton, C. J.; De Waal, S. A.; Gibson, R. L.

1995-11-01

Two calc-silicate xenoliths in the Upper Zone of the Bushveld complex contain mineral assemblages which permit delineation of the metamorphic path followed after incorporation of the xenoliths into the magma. Peak metamorphism in these xenoliths occurred at T=1100-1200°C and P <1.5 kbar. Retrograde metamorphism, probably coinciding with the late magmatic stage, is characterized by the breakdown of akermanite to monticellite and wollastonite at 700°C and the growth of vesuvianite from melilite. The latter implies that water-rich fluids (X CO 2 <0.2) were present and probably circulating through the cooling magmatic pile. In contrast, calc-silicate xenoliths within the lower zones of the Bushveld complex, namely in the Marginal and Critical Zones, also contain melilite, monticellite and additional periclase with only rare development of vesuvianite. This suggests that the Upper Zone cumulate pile was much 'wetter' in the late-magmatic stage than the earlier-formed Critical and Marginal Zone cumulate piles.

The Pennsylvanian-early permian bird spring carbonate shelf, Southeastern California: Fusulinid biostratigraphy, paleogeographic evolution, and tectonic implications

USGS Publications Warehouse

Stevens, C.H.; Stone, P.

2007-01-01

The Bird Spring Shelf in southeastern California, along with coeval turbidite basins to the west, records a complex history of late Paleozoic sedimentation, sea-level changes, and deformation along the western North American continental margin. We herein establish detailed correlations between deposits of the shelf and the flanking basins, which we then use to reconstruct the depositional history, paleogeography, and deformational history, including Early Permian emplacement of the regionally significant Last Chance allochthon. These correlations are based on fusulinid faunas, which are numerous both on the shelf and in the adjoining basins. Study of 69 fusulinid species representing all major fusulinid-bearing Pennsylvanian and Lower Permian limestone outcrops of the Bird Spring Shelf in southeastern California, including ten new species of the genera Triticites, Leptotriticites, Stewartina, Pseudochusenella, and Cuniculinella, forms the basis for our correlations. We group these species into six fusulinid zones that we correlate with fusulinid-bearing strata in east-central and southern Nevada, Kansas, and West Texas, and we propose some regional correlations not previously suggested. In addition, we utilize recent conodont data from these areas to correlate our Early Permian fusulinid zones with the standard Global Permian Stages, strengthening their chronostratigraphic value. Our detailed correlations between the fusulinid-bearing rocks of the Bird Spring Shelf and deep-water deposits to the northwest reveal relationships between the history of shelf sedimentation and evolution of basins closer to the continental margin. In Virgilian to early Asselian (early Wolfcampian) time (Fusulinid Zones 1 and 2), the Bird Spring Shelf was flanked on the west by the deep-water Keeler Basin in which calcareous turbidites derived from the shelf were deposited. In early Sakmarian (early middle Wolfcampian) time (Fusulinid Zone 3), the Keeler Basin deposits were uplifted and transported eastward on the Last Chance thrust. By middle Sakmarian (middle middle Wolfcampian) time (within Fusulinid Zone 4), emplacement of the Last Chance allochthon was complete, and subsidence caused by thrust loading had resulted in development of a new turbidite basin (Darwin Basin) along the former western part of the Bird Spring Shelf. At the same time, farther east into the craton, paralic facies began prograding westward, so that the youngest fusulinid-bearing limestones on the shelf in this area become progressively younger to the west. Eventually, in Artinskian to Kungurian (late Wolfcampian to Leonardian) time (Fusulinid Zones 5 and 6), deposition of fusulinid-bearing limestone on the shelf was restricted to a marginal belt between the prograding paralic facies to the east and the Darwin Basin to the west. Development of the Keeler Basin in Pennsylvanian to earliest Permian time was approximately coeval with collision between South America-Africa (Gondwana) and North America (Laurentia) on the Ouachita-Marathon orogenic belt. This basin developed inboard of a northwest-trending, sinistral fault zone that truncated the continental margin. Later, in the Early Permian, the Last Chance allochthon, which was part of a northeast-trending belt of deformation that extended into northeastern Nevada, was emplaced. This orogenic belt probably was driven by convergence at the continental margin to the northwest. This work adds significant detail to existing interpretations of the late Paleozoic as a time of major tectonic instability on the continental margin of southeastern California as it changed from a relatively passive margin that had characterized most of the Paleozoic to an active convergent margin that would characterize the Mesozoic. ?? 2007 The Geological Society of America. All rights reserved.

Geoelectric structure of northern Cambay rift basin from magnetotelluric data

NASA Astrophysics Data System (ADS)

Danda, Nagarjuna; Rao, C. K.; Kumar, Amit

2017-10-01

Broadband and long-period magnetotelluric data were acquired over the northern part of the Cambay rift zone along an east-west profile 200 km in length. The decomposed TE- and TM-mode data were inverted using a 2-D nonlinear conjugate gradient algorithm to obtain the lithospheric structure of the region. A highly conductive ( 1000 S) layer was identified within the Cambay rift zone and interpreted as thick Quaternary and Tertiary sediments. The crustal conductors found in the profile were due to fluid emplacement in the western part, and the presence of fluids and/or interconnected sulfides caused by metamorphic phases in the eastern part. The demarcation of the Cambay rift zone is clearly delineated with a steeply dipping fault on the western margin, whereas the eastern margin of the rift zone gently dips along the NE-SW axis, representing a half-graben structure. A highly resistive body identified outside the rift zone is interpreted as an igneous granitic intrusive complex. Moderately conductive (30-100 Ω-m) zones indicate underplating and the presence of partial melt due to plume-lithosphere interactions.[Figure not available: see fulltext.

Architecture of the Distal Piedmont-Ligurian Rifted Margin in NW Italy: Hints for a Flip of the Rift System Polarity

NASA Astrophysics Data System (ADS)

Decarlis, Alessandro; Beltrando, Marco; Manatschal, Gianreto; Ferrando, Simona; Carosi, Rodolfo

2017-11-01

The Alpine Tethys rifted margins were generated by a Mesozoic polyphase magma-poor rifting leading to the opening of the Piedmont-Ligurian "Ocean." This latter developed through different phases of rifting that terminated with the exhumation of subcontinental mantle along an extensional detachment system. At the onset of simple shear detachment faulting, two margin types were generated: an upper and a lower plate corresponding to the hanging wall and footwall of the final detachment system, respectively. The two margin architectures were markedly different and characterized by a specific asymmetry. In this study the detailed analysis of the Adriatic margin, exposed in the Serie dei Laghi, Ivrea-Verbano, and Canavese Zone, enabled to recognize the diagnostic elements of an upper plate rifted margin. This thesis contrasts with the classic interpretation of the Southalpine units, previously compared with the adjacent fossil margin preserved in the Austroalpine nappes and considered as part of a lower plate. The proposed scenario suggests the segmentation and flip of the Alpine rifting system along strike and the passage from a lower to an upper plate. Following this interpretation, the European and Southern Adria margins are coevally developed upper plate margins, respectively resting NE and SW of a major transform zone that accommodates a flip in the polarity of the rift system. This new explanation has important implications for the study of the pre-Alpine rift-related structures, for the comprehension of their role during the reactivation of the margin and for the paleogeographic evolution of the Alpine orogen.

Semidiurnal Temperature Changes Caused by Tidal Front Movements in the Warm Season in Seabed Habitats on the Georges Bank Northern Margin and Their Ecological Implications

PubMed Central

Guida, Vincent G.; Valentine, Page C.; Gallea, Leslie B.

2013-01-01

Georges Bank is a large, shallow feature separating the Gulf of Maine from the Atlantic Ocean. Previous studies demonstrated a strong tidal-mixing front during the warm season on the northern bank margin between thermally stratified water in the Gulf of Maine and mixed water on the bank. Tides transport warm water off the bank during flood tide and cool gulf water onto the bank during ebb tide. During 10 days in August 2009, we mapped frontal temperatures in five study areas along ∼100 km of the bank margin. The seabed “frontal zone”, where temperature changed with frontal movment, experienced semidiurnal temperature maxima and minima. The tidal excursion of the frontal boundary between stratified and mixed water ranged 6 to 10 km. This “frontal boundary zone” was narrower than the frontal zone. Along transects perpendicular to the bank margin, seabed temperature change at individual sites ranged from 7.0°C in the frontal zone to 0.0°C in mixed bank water. At time series in frontal zone stations, changes during tidal cycles ranged from 1.2 to 6.1°C. The greatest rate of change (−2.48°C hr−1) occurred at mid-ebb. Geographic plots of seabed temperature change allowed the mapping of up to 8 subareas in each study area. The magnitude of temperature change in a subarea depended on its location in the frontal zone. Frontal movement had the greatest effect on seabed temperature in the 40 to 80 m depth interval. Subareas experiencing maximum temperature change in the frontal zone were not in the frontal boundary zone, but rather several km gulfward (off-bank) of the frontal boundary zone. These results provide a new ecological framework for examining the effect of tidally-driven temperature variability on the distribution, food resources, and reproductive success of benthic invertebrate and demersal fish species living in tidal front habitats. PMID:23405129

Subduction-zone magnetic anomalies and implications for hydrated forearc mantle

USGS Publications Warehouse

Blakely, R.J.; Brocher, T.M.; Wells, R.E.

2005-01-01

Continental mantle in subduction zones is hydrated by release of water from the underlying oceanic plate. Magnetite is a significant byproduct of mantle hydration, and forearc mantle, cooled by subduction, should contribute to long-wavelength magnetic anomalies above subduction zones. We test this hypothesis with a quantitative model of the Cascadia convergent margin, based on gravity and aeromagnetic anomalies and constrained by seismic velocities, and find that hydrated mantle explains an important disparity in potential-field anomalies of Cascadia. A comparison with aeromagnetic data, thermal models, and earthquakes of Cascadia, Japan, and southern Alaska suggests that magnetic mantle may be common in forearc settings and thus magnetic anomalies may be useful in mapping hydrated mantle in convergent margins worldwide. ?? 2005 Geological Society of America.

The Flemish Cap - Goban Spur conjugate margins: New evidence of asymmetry

NASA Astrophysics Data System (ADS)

Gerlings, J.; Louden, K. E.; Minshull, T. A.; Nedimović, M. R.

2011-12-01

The combined results of deep multichannel seismic (MCS) and refraction/wide-angle reflection seismic (R/WAR) profiles across the Flemish Cap-Goban Spur conjugate margin pair will be presented to help constrain rifting and breakup processes. Both profiles cross magnetic anomaly 34 and extend into oceanic crust, which makes it possible to observe the complete extensional history from continental rifting through the formation of initial oceanic crust. Kirchhoff poststack time and prestack time and depth migration images of the Flemish Cap MCS data are produced using a velocity model constructed from the MCS and R/WAR data. These new images show improved continuity of the Moho under the thick continental crust of Flemish Cap. The basement morphology image is sharper and reflections observed in the thin crust of the transition zone are more coherent. A basement high at the seaward-most end of the transition zone now displays clear diapiric features. To compare the two margins, the existing migrated MCS data across Goban Spur has been time-to-depth converted using the R/WAR velocity model of the margin. These reimaged seismic profiles demonstrate asymmetries in continental rifting and breakup with a complex transition to oceanic spreading: (1) During initial phases of rifting, the Flemish Cap margin displays a sharper necking profile than that of the Goban Spur margin. (2) Within the ocean-continent-transition zone, constraints from S-wave velocities on both margins indentifies previously interpreted oceanic crust as thinned continental crust offshore Flemish Cap in contrast with primarily serpentinized mantle offshore Goban Spur. (3) Continental breakup and initial seafloor spreading occur in a complex, asymmetric manner where the initial ~50 km of oceanic crust appears different on the two margins. Offshore Flemish Cap, both R/WAR and MCS results indicate a sharp boundary immediately seaward of a ridge feature, where the basement morphology becomes typical of slow seafloor spreading. There are no significant changes in either reflectivity or velocity seaward toward magnetic anomaly 34. On the Goban Spur margin in marked contrast, the basement morphology landward of magnetic anomaly 34 is shallower and has lower relief, and the velocity model indicates a diffuse change between the transitional crust and seafloor spreading. The results from these two very different conjugate margins emphasize the importance of having both types of seismic data from both conjugate margins when interpreting the geodynamic processes.

Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity.

PubMed Central

Jares, P.; Campo, E.; Pinyol, M.; Bosch, F.; Miquel, R.; Fernandez, P. L.; Sanchez-Beato, M.; Soler, F.; Perez-Losada, A.; Nayach, I.; Mallofré, C.; Piris, M. A.; Montserrat, E.; Cardesa, A.

1996-01-01

Mantle cell lymphomas (MCLs) are molecularly characterized by bcl-1 rearrangement and constant cyclin D1 (PRAD-1/CCND1) gene overexpression. Cyclin D1 is a G1 cyclin that participates in the control of the cell cycle progression by interacting with the retinoblastoma gene product (pRb). Inactivation of the Rb tumor suppressor gene has been implicated in the development of different types of human tumors including some high grade non-Hodgkin's lymphomas. To determine the role of the retinoblastoma gene in the pathogenesis of MCLs and its possible interaction with cyclin D1, pRb expression was examined in 23 MCLs including 17 typical and 6 blastic variants by immunohistochemistry and Western blot. Rb gene structure was studied in 13 cases by Southern blot. Cytogenetic analysis was performed in 5 cases. The results were compared with the cyclin D1 mRNA levels examined by Northern analysis, and the proliferative activity of the tumors was measured by Ki-67 growth fraction and flow cytometry. pRb was expressed in all MCLs. The expression varied from case to case (mean, 14.1% of positive cells; range, 1.3 to 42%) with a significant correlation with the proliferative activity of the tumors (mitotic index r = 0.85; Ki-67 r = 0.7; S phase = 0.73). Blastic variants showed higher numbers of pRb-positive cells (mean, 29%) than the typical cases (10%; P < 0.005) by immunohistochemistry and, concordantly, higher levels of expression by Western blot. In addition, the blastic cases also had an increased expression of the phosphorylated protein. No alterations in Rb gene structure were observed by Southern blot analysis. Cyclin D1 mRNA levels were independent of pRb expression and the proliferative activity of the tumors. These findings suggest that pRb in MCLs is normally regulated in relation to the proliferative activity of the tumors. Cyclin D1 overexpression may play a role in the maintenance of cell proliferation by overcoming the suppressive growth control of pRb. Images Figure 1 Figure 2 Figure 4 PMID:8623927

Actively dewatering fluid-rich zones along the Costa Rica plate boundary fault

NASA Astrophysics Data System (ADS)

Bangs, N. L.; McIntosh, K. D.; Silver, E. A.; Kluesner, J. W.; Ranero, C. R.; von Huene, R.

2012-12-01

New 3D seismic reflection data reveal distinct evidence for active dewatering above a 12 km wide segment of the plate boundary fault within the Costa Rica subduction zone NW of the Osa Peninsula. In the spring of 2011 we acquired a 11 x 55 km 3D seismic reflection data set on the R/V Langseth using four 6,000 m streamers and two 3,300 in3 airgun arrays to examine the structure of the Costa Rica margin from the trench into the seismogenic zone. We can trace the plate-boundary interface from the trench across our entire survey to where the plate-boundary thrust lies > 10 km beneath the margin shelf. Approximately 20 km landward of the trench beneath the mid slope and at the updip edge of the seismogenic zone, a 12 km wide zone of the plate-boundary interface has a distinctly higher-amplitude seismic reflection than deeper or shallower segments of the fault. Directly above and potentially directly connected with this zone are high-amplitude, reversed-polarity fault-plane reflections that extend through the margin wedge and into overlying slope sediment cover. Within the slope cover, high-amplitude reversed-polarity reflections are common within the network of closely-spaced nearly vertical normal faults and several broadly spaced, more gently dipping thrust faults. These faults appear to be directing fluids vertically toward the seafloor, where numerous seafloor fluid flow indicators, such as pockmarks, mounds and ridges, and slope failure features, are distinct in multibeam and backscatter images. There are distinctly fewer seafloor and subsurface fluid flow indicators both updip and downdip of this zone. We believe these fluids come from a 12 km wide fluid-rich segment of the plate-boundary interface that is likely overpressured and has relatively low shear stress.

Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas

ClinicalTrials.gov

2015-04-28

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Epstein-Barr Virus Infection; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia

Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies

ClinicalTrials.gov

2015-10-13

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Graft Versus Host Disease; Intraocular Lymphoma; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Ringed Sideroblasts; Refractory Chronic Lymphocytic Leukemia; Refractory Cytopenia With Multilineage Dysplasia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Central Nervous System Hodgkin Lymphoma; Secondary Central Nervous System Non-Hodgkin Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Results of Upfront Therapy for Marginal Zone Lymphoma.

PubMed

Ortega, José L; Cabanillas, Fernando; Rivera, Noridza; Tirado-Gomez, Maribel; Hallman, Deana; Pardo, Wandaly I; Bruno, Margarita

2017-12-01

Marginal zone lymphomas (MZLs) are indolent disorders composed of 3 subtypes: extranodal marginal zone lymphoma (MALT), splenic marginal zone lymphoma (SMZL), and nodal marginal zone lymphoma (NMZL). Early-stage MALT is treated with radiotherapy or antibiotics, and advanced MALT and NMZL are managed with either watch and wait or chemotherapy. SMZLs are treated with splenectomy or rituximab. However, because these approaches have failed to cure patients with SMZL and NMZL, we have systematically used upfront chemotherapy for them, as well as for advanced MALT. We report the outcomes of this approach. A total of 44 patients with MZL were identified from our database and divided into 2 groups. Group 1 (22 with early-stage MALT) patients received either radiotherapy (n = 17) or antibiotics with or without surgery (n = 5). Group 2 included 9 patients with advanced MALT, 9 with SMZL, and 4 with NMZL. Group 2 was treated with FND-R (fludarabine 25 mg/m 2 on days 1 to 3, mitoxantrone 10 mg/m 2 on day 1, dexamethasone 20 mg on days 1 to 5, and rituximab 375 mg/m 2 on day 1; n = 14) or CHOP-R (cyclophosphamide 750 mg/m 2 on day 1, doxorubicin 50 mg/m 2 on day 1, vincristine 2 mg intravenous push on day 1, prednisone 100 mg/m 2 orally on days 1 to 5, rituximab 375 mg/m 2 on day 1; n = 8), followed by maintenance rituximab for 70%. All patients achieved complete remission, and only 2 patients in group 1 had developed a relapse at 70 and 75 months. Both relapses were stage I MALT that had initially been treated with radiotherapy. Both were salvaged with FND-R and remained free of disease at 27 and 39 months after the relapse. At 10 years, the failure-free survival for the 44 patients was 80% and the overall survival was 100%. None of the patients in group 2 developed a relapse. The long-term toxicities have been acceptable. The excellent responses using upfront chemotherapy for MZL suggests that this disorder is curable. Our results should be confirmed in a prospective trial. Copyright © 2017 Elsevier Inc. All rights reserved.

Lenalidomide After Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancers

ClinicalTrials.gov

2017-09-22

Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A; Adult Acute Promyelocytic Leukemia With PML-RARA; Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Alkylating Agent-Related Acute Myeloid Leukemia; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Post-Transplant Lymphoproliferative Disorder; Primary Cutaneous B-Cell Non-Hodgkin Lymphoma; Prolymphocytic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Non-Hodgkin Lymphoma; Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Richter Syndrome; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenstrom Macroglobulinemia

A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies

ClinicalTrials.gov

2017-12-04

Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Aplastic Anemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Myelodysplastic Syndromes; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Essential Thrombocythemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Juvenile Myelomonocytic Leukemia; Mastocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Polycythemia Vera; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Anemia; Refractory Anemia With Ringed Sideroblasts; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Waldenström Macroglobulinemia

Complex Modeling of the Seismic Structure of the Trans-European Suture Zone's Margin from Receiver Function Analysis

NASA Astrophysics Data System (ADS)

Wilde-Piorko, M.; Chrapkiewicz, K.; Lepore, S.; Polkowski, M.; Grad, M.

2016-12-01

The Trans-European Suture Zone (TESZ) is one of the most prominent suture zones in Europe separating the young Paleozoic Platform from the much older Precambrian East European Craton. The data recorded by "13 BB Star" broadband seismic stations (Grad et al., 2015) are analyzed to investigate the crustal and upper mantle structure of the margin of the Trans-European Suture Zone (TESZ) in northern Poland. Receiver function (RF) locally provides the signature of sharp seismic discontinuities and information about the shear wave (S-wave) velocity distribution beneath the seismic station. Recorded seismograms are rotated from ZNE to LQT system with method using the properties of RF (Wilde-Piórko, 2015). Different techniques of receiver function interpretation are applied, including 1-D inversion of RF, 1-D forward modeling of RF, 2.5D forward modeling of RF, 1-D join inversion of RF and dispersion curves of surface wave, to find the best S-wave velocity model of the TESZ margin. A high-resolution 3D P-wave velocity model in the area of Poland (Grad et al. 2016) are used as a starting model. National Science Centre Poland provided financial support for this work by NCN grant DEC-2011/02/A/ST10/00284.

The role of the margins in ice stream dynamics

NASA Technical Reports Server (NTRS)

Echelmeyer, Keith; Harrison, William

1993-01-01

At first glance, it would appear that the bed of the active ice stream plays a much more important role in the overall force balance than do the margins, especially because the ratio of the half-width to depth for a typical ice stream is large (15:1 to 50:1). On the other hand, recent observations indicate that at least part of the ice stream is underlain by a layer of very weak till (shear strength about 2 kPa), and this weak basal layer would then imply that some or all of the resistive drag is transferred to the margins. In order to address this question, a detailed velocity profile near Upstream B Camp, which extends from the center of the ice stream, across the chaotic shear margin, and onto the Unicorn, which is part of the slow-moving ice sheet was measured. Comparison of this observed velocity profile with finite-element models of flow shows several interesting features. First, the shear stress at the margin is on the order of 130 kPa, while the mean value along the bed is about 15 kPa. Integration of these stresses along the boundaries indicates that the margins provide 40 to 50 percent, and the bed, 60 to 40 percent of the total resistive drag needed to balance the gravitational driving stress in this region. (The range of values represents calculations for different values of surface slope.) Second, the mean basal stress predicted by the models shows that the entire bed cannot be blanketed by the weak till observed beneath upstream B - instead there must be a distribution of weak till and 'sticky spots' (e.g., 85 percent till and 15 percent sticky spots of resistive stress equal to 100 kPa). If more of the bed were composed of weak till, then the modeled velocity would not match that observed. Third, the ice must exhibit an increasing enhancement factor as the margins are approached (E equals 10 in the chaotic zone), in keeping with laboratory measurements on ice under prolonged shear strain. Also, there is either a narrow zone of somewhat stiffer ice (E equals 5) outward of the shear margin, or the bed is frozen there. And last, the high shear stress and strain rate found at the margin are likely to cause significant viscous heating (q) in the marginal ice. The increase in temperature is proportional to qX/u, where X is the width of the shear zone and u is the transverse velocity component bringing cold ice in from the ice sheet outside the shear zone. Near upstream B, this heating is likely to cause an increase in temperature of 4 to 10 K. Plans are to measure this temperature increase in a series of bore holes near the margin during the 1992-93 field season, as well as to provide a more detailed description of the velocity field there.

The role of the margins in ice stream dynamics

NASA Astrophysics Data System (ADS)

Echelmeyer, Keith; Harrison, William

1993-07-01

At first glance, it would appear that the bed of the active ice stream plays a much more important role in the overall force balance than do the margins, especially because the ratio of the half-width to depth for a typical ice stream is large (15:1 to 50:1). On the other hand, recent observations indicate that at least part of the ice stream is underlain by a layer of very weak till (shear strength about 2 kPa), and this weak basal layer would then imply that some or all of the resistive drag is transferred to the margins. In order to address this question, a detailed velocity profile near Upstream B Camp, which extends from the center of the ice stream, across the chaotic shear margin, and onto the Unicorn, which is part of the slow-moving ice sheet was measured. Comparison of this observed velocity profile with finite-element models of flow shows several interesting features. First, the shear stress at the margin is on the order of 130 kPa, while the mean value along the bed is about 15 kPa. Integration of these stresses along the boundaries indicates that the margins provide 40 to 50 percent, and the bed, 60 to 40 percent of the total resistive drag needed to balance the gravitational driving stress in this region. (The range of values represents calculations for different values of surface slope.) Second, the mean basal stress predicted by the models shows that the entire bed cannot be blanketed by the weak till observed beneath upstream B - instead there must be a distribution of weak till and 'sticky spots' (e.g., 85 percent till and 15 percent sticky spots of resistive stress equal to 100 kPa). If more of the bed were composed of weak till, then the modeled velocity would not match that observed. Third, the ice must exhibit an increasing enhancement factor as the margins are approached (E equals 10 in the chaotic zone), in keeping with laboratory measurements on ice under prolonged shear strain. Also, there is either a narrow zone of somewhat stiffer ice (E equals 5) outward of the shear margin, or the bed is frozen there. And last, the high shear stress and strain rate found at the margin are likely to cause significant viscous heating (q) in the marginal ice. The increase in temperature is proportional to qX/u, where X is the width of the shear zone and u is the transverse velocity component bringing cold ice in from the ice sheet outside the shear zone. Near upstream B, this heating is likely to cause an increase in temperature of 4 to 10 K. Plans are to measure this temperature increase in a series of bore holes near the margin during the 1992-93 field season, as well as to provide a more detailed description of the velocity field there.

Geophysical constraints on geodynamic processes at convergent margins: A global perspective

NASA Astrophysics Data System (ADS)

Artemieva, Irina; Thybo, Hans; Shulgin, Alexey

2016-04-01

Convergent margins, being the boundaries between colliding lithospheric plates, form the most disastrous areas in the world due to intensive, strong seismicity and volcanism. We review global geophysical data in order to illustrate the effects of the plate tectonic processes at convergent margins on the crustal and upper mantle structure, seismicity, and geometry of subducting slab. We present global maps of free-air and Bouguer gravity anomalies, heat flow, seismicity, seismic Vs anomalies in the upper mantle, and plate convergence rate, as well as 20 profiles across different convergent margins. A global analysis of these data for three types of convergent margins, formed by ocean-ocean, ocean-continent, and continent-continent collisions, allows us to recognize the following patterns. (1) Plate convergence rate depends on the type of convergent margins and it is significantly larger when, at least, one of the plates is oceanic. However, the oldest oceanic plate in the Pacific ocean has the smallest convergence rate. (2) The presence of an oceanic plate is, in general, required for generation of high-magnitude (M N 8.0) earthquakes and for generating intermediate and deep seismicity along the convergent margins. When oceanic slabs subduct beneath a continent, a gap in the seismogenic zone exists at depths between ca. 250 km and 500 km. Given that the seismogenic zone terminates at ca. 200 km depth in case of continent-continent collision, we propose oceanic origin of subducting slabs beneath the Zagros, the Pamir, and the Vrancea zone. (3) Dip angle of the subducting slab in continent-ocean collision does not correlate neither with the age of subducting oceanic slab, nor with the convergence rate. For ocean-ocean subduction, clear trends are recognized: steeply dipping slabs are characteristic of young subducting plates and of oceanic plates with high convergence rate, with slab rotation towards a near-vertical dip angle at depths below ca. 500 km at very high convergence rate. (4) Local isostasy is not satisfied at the convergent margins as evidenced by strong free air gravity anomalies of positive and negative signs. However, near-isostatic equilibrium may exist in broad zones of distributed deformation such as Tibet. (5) No systematic patterns are recognized in heat flow data due to strong heterogeneity of measured values which are strongly affected by hydrothermal circulation, magmatic activity, crustal faulting, horizontal heat transfer, and also due to low number of heat flow measurements across many margins. (6) Low upper mantle Vs seismic velocities beneath the convergent margins are restricted to the upper 150 km and may be related to mantle wedge melting which is confined to shallow mantle levels. Artemieva, I.M., Thybo, H., and Shulgin, A., 2015. Geophysical constraints on geodynamic processes at convergent margins: A global perspective. Gondwana Research, http://dx.doi.org/10.1016/j.gr.2015.06.010

CD79B and MYD88 Mutations in Splenic Marginal Zone Lymphoma

PubMed Central

Trøen, Gunhild; Warsame, Abdirashid; Delabie, Jan

2013-01-01

The mutation status of genes involved in the NF-κB signaling pathway in splenic marginal zone lymphoma was examined. DNA sequence analysis of four genes was performed: CD79A, CD79B, CARD11, and MYD88 that are activated through BCR signaling or Toll-like and interleukin signaling. A single point mutation was detected in the CD79B gene (Y196H) in one of ten SMZL cases. Additionally, one point mutation was identified in the MYD88 gene (L265P) in another SMZL case. No mutations were revealed in CD79A or CARD11 genes in these SMZL cases. Neither were mutations detected in these four genes studied in 13 control MZL samples. Interestingly, the two cases with mutations of CD79B and MYD88 showed increased numbers of immunoblasts spread among the smaller and typical marginal zone lymphoma cells. Although SMZL shows few mutations of NF-κB signaling genes, our results indicate that the presence of these mutations is associated with a higher histological grade. PMID:23378931

Marine forearc extension in the Hikurangi Margin: New insights from high-resolution 3D seismic data

NASA Astrophysics Data System (ADS)

Böttner, Christoph; Gross, Felix; Geersen, Jacob; Mountjoy, Joshu; Crutchley, Gareth; Krastel, Sebastian

2017-04-01

In subduction zones upper-plate normal faults have long been considered a tectonic feature primarily associated with erosive margins. However, increasing data coverage has proven that similar features also occur in accretionary margins, such as Cascadia, Makran, Nankai or Central Chile, where kinematics are dominated by compression. Considering their wide distribution there is, without doubt, a significant lack of qualitative and quantitative knowledge regarding the role and importance of normal faults and zones of extension for the seismotectonic evolution of accretionary margins. We use a high-resolution 3D P-Cable seismic volume from the Hikurangi Margin acquired in 2014 to analyze the spatial distribution and mechanisms of upper-plate normal faulting. The study area is located at the upper continental slope in the area of the Tuaheni landslide complex. In detail we aim to (1) map the spatial distribution of normal faults and characterize their vertical throws, strike directions, and dip angles; (2) investigate their possible influence on fluid migration in an area, where gas hydrates are present; (3) discuss the mechanisms that may cause extension of the upper-slope in the study area. Beneath the Tuaheni Landslide Complex we mapped about 200 normal faults. All faults have low displacements (<15 m) and dip at high (> 65°) angles. About 71% of the faults dip landward. We found two main strike directions, with the majority of faults striking 350-10°, parallel to the deformation front. A second group of faults strikes 40-60°. The faults crosscut the BSR, which indicates the base of the gas hydrate zone. In combination with seismically imaged bright-spots and pull-up structures, this indicates that the normal faults effectively transport fluids vertically across the base of the gas hydrate zone. Localized uplift, as indicated by the presence of the Tuaheni Ridge, might support normal faulting in the study area. In addition, different subduction rates across the margin may also favor extension between the segments. Future work will help to further untangle the mechanisms that cause extension of the upper continental slope.

Deep structure of the Algerian margin offshore Great Kabylie: Preliminary results of an offshore-onshore seismic profile (SPIRAL campaign)

NASA Astrophysics Data System (ADS)

Chafik, Aidi; Abd el Karim, Yelles; Marie-Odile, Beslier; Frauke, Klingelhoefer; Philippe, Schnurle; Rabah, Bracene; Hamou, Djellit; Audrey, Galve; Laure, Schenini; Françoise, Sage; Abdallah, Bounif Mohand ou; Philippe, Charvis

2013-04-01

In October-November 2009 the Algerian-French SPIRAL research program (Sismique Profonde et Investigation Régionale du Nord de l'ALgérie) was conducted onboard the R/V Atalante in order to understand the deep structure and tectonic history of the Algerian Margin using multichannel and wide-angle seismic data. An extensive dataset was acquired along five regional transects off Algeria, from Arzew Bay to the west, to Annaba to the east. The profiles range from 80 to 180 km long and around 40 ocean-bottom seismometers were deployed on each profile. All profiles were extended on land up to 125 km by land-stations to better constrain the structure of the margin and the nature of the ocean-continent transition zone. We present the preliminary results from modeling of deep and superficial structures in the central Algerian margin, more precisely in the region of the Great Kabylie where a N-S transect of combined wide-angle data using a set of 40 OBS (ocean bottom seismometer) and 24 on-land seismological stations and reflection seismic data was acquired. The profile with a total length of about 260 km (140 km offshore and approximately 124 km onshore), crosses from the north to south the Algeria-Provence Basin, the central Algerian Margin and onshore the geological unit of the Great Kabylie that represents the Kabylides block and the transitional zone between the internal zone (Kabylides) and the external zone in the central Algeria. The network (OBS and seismological stations), recorded 1031 low frequency air gun shots in order to ensure good penetration in the crust. Travel time tomography of first arrivals time of OBS data has yielded a preliminary model of P wave velocities along the profile. In the oceanic domain, a relatively thin crust of about 5 km thickness was imaged overlying a mantle characterized by seismic velocities of about 8 km/s, and covered by a thin sedimentary layer of about 2 km thickness. For the study of the sedimentary cover near the margin several MCS profiles were acquired in this region during the Spiral survey and previously by the Maradja cruise. This data sets allows to image reactivation of the Algerian Margin in this region.

Compositional and mineralogical zoning by inward crystallization of mafic magma: evidence from the Guwoon hornblende gabbro-diorite Complex, Hwacheon, Korea.

NASA Astrophysics Data System (ADS)

Park, Y.-R.; Kim, G.-Y.

2009-04-01

The small body, ca. 1.3 by 1.6km, of a hot-air ballon shape hornblende gabbro - diorite Complex, in Gowoonri, Hwacheon, Korea consists of marginal diorite and central hornblende gabbro. The volumetrically dominant hornblende gabbro in the core of the Complex shows a zoned distribution with three layers distinguished by different dominant mafic mineral phases. From the margin toward the core of the hornblende gabbro body, the domintant mafic minerals change from amphibole phenocryst of nearly rounded shape in cross section with pyroxene pseudomorph through prismatic shape of amphibole to polycrystalline biotite aggregates. Systematic variations in geochemical characteristics among three distinct zones of hornblende gabbro body are also observed. From the outer zone toward the core, major oxides such as MnO, MgO, and CaO show a decreasing tendency, whereas total FeO/(total FeO + MgO) value shows an increasing tendency. Concentrations of trace elements also show systematic variations. Where incompatible elements such as Ba and Th increase, compatible elements like Cr and Sc decrease from the margin toward the core. The zonal distribution divided by change in dominant mafic mineral phase from pyroxene through amphibole to biotite, and systematic compositional changes in both major and trace elements from the outer zone toward the core of the hornblende gabbro body suggest that an inward crystallization mechanism played a major role in the formation of the hornblende gabbro in Guwoonri, Hwacheon, Korea.

Geology of the Elephanta Island fault zone, western Indian rifted margin, and its significance for understanding the Panvel flexure

NASA Astrophysics Data System (ADS)

Samant, Hrishikesh; Pundalik, Ashwin; D'souza, Joseph; Sheth, Hetu; Lobo, Keegan Carmo; D'souza, Kyle; Patel, Vanit

2017-02-01

The Panvel flexure is a 150-km long tectonic structure, comprising prominently seaward-dipping Deccan flood basalts, on the western Indian rifted margin. Given the active tectonic faulting beneath the Panvel flexure zone inferred from microseismicity, better structural understanding of the region is needed. The geology of Elephanta Island in the Mumbai harbour, famous for the ca. mid-6th century A.D. Hindu rock-cut caves in Deccan basalt (a UNESCO World Heritage site) is poorly known. We describe a previously unreported but well-exposed fault zone on Elephanta Island, consisting of two large faults dipping steeply east-southeast and producing easterly downthrows. Well-developed slickensides and structural measurements indicate oblique slip on both faults. The Elephanta Island fault zone may be the northern extension of the Alibag-Uran fault zone previously described. This and two other known regional faults (Nhava-Sheva and Belpada faults) indicate a progressively eastward step-faulted structure of the Panvel flexure, with the important result that the individual movements were not simply downdip but also oblique-slip and locally even rotational (as at Uran). An interesting problem is the normal faulting, block tectonics and rifting of this region of the crust for which seismological data indicate a normal thickness (up to 41.3 km). A model of asymmetric rifting by simple shear may explain this observation and the consistently landward dips of the rifted margin faults.

Diffuse Extension of the Southern Mariana Margin: Implications for Subduction Zone Infancy and Plate Tectonics

NASA Astrophysics Data System (ADS)

Martinez, F.; Stern, R. J.; Kelley, K. A.; Ohara, Y.; Sleeper, J. D.; Ribeiro, J. M.; Brounce, M. N.

2017-12-01

Opening of the southern Mariana margin takes place in contrasting modes: Extension normal to the trench forms crust that is passively accreted to a rigid Philippine Sea plate and forms along focused and broad accretion axes. Extension also occurs parallel to the trench and has split apart an Eocene-Miocene forearc terrain accreting new crust diffusely over a 150-200 km wide zone forming a pervasive volcano-tectonic fabric oriented at high angles to the trench and the backarc spreading center. Earthquake seismicity indicates that the forearc extension is active over this broad area and basement samples date young although waning volcanic activity. Diffuse formation of new oceanic crust and lithosphere is unusual; in most oceanic settings extension rapidly focuses to narrow plate boundary zones—a defining feature of plate tectonics. Diffuse crustal accretion has been inferred to occur during subduction zone infancy, however. We hypothesize that, in a near-trench extensional setting, the continual addition of water from the subducting slab creates a weak overriding hydrous lithosphere that deforms broadly. This process counteracts mantle dehydration and strengthening proposed to occur at mid-ocean ridges that may help to focus deformation and melt delivery to narrow plate boundary zones. The observations from the southern Mariana margin suggest that where lithosphere is weakened by high water content narrow seafloor spreading centers cannot form. These conditions likely prevail during subduction zone infancy, explaining the diffuse contemporaneous volcanism inferred in this setting.

Deep crustal earthquakes associated with continental rifts

NASA Astrophysics Data System (ADS)

Doser, Diane I.; Yarwood, Dennis R.

1994-01-01

Deep (> 20 km) crustal earthquakes have occurred within or along the margins of at least four continental rift zones. The largest of these deep crustal earthquakes ( M ⩾ 5.0) have strike-slip or oblique-slip mechanisms with T-axes oriented similarly to those associated with shallow normal faulting within the rift zones. The majority of deep crustal earthquakes occur along the rift margins in regions that have cooler, thicker crust. Several deep crustal events, however, occur in regions of high heat flow. These regions also appear to be regions of high strain, a factor that could account for the observed depths. We believe the deep crustal earthquakes represent either the relative motion of rift zones with respect to adjacent stable regions or the propagation of rifting into stable regions.

Tectonics and Current Plate Motions of Northern Vancouver Island and the Adjacent Mainland

NASA Astrophysics Data System (ADS)

Jiang, Y.; Leonard, L. J.; Henton, J.; Hyndman, R. D.

2016-12-01

Northern Vancouver Island comprises a complex transition zone along the western margin of the North America plate, between the subducting Juan de Fuca plate to the south and the transcurrent Queen Charlotte Fault to the north off Haida Gwaii. The tectonic history and seismic potential for this region are unclear. Here we present current plate motions for northern Vancouver Island and the adjacent mainland, determined from continuous and campaign GPS measurements processed in a consistent manner. Immediately to the north of the mid-Vancouver Island Nootka Fault Zone, the northern limit of Juan de Fuca plate subduction, GPS velocity vectors show slower Explorer plate subduction than the Juan de Fuca Plate. Off northernmost Vancouver Island, the Winona Block is possibly converging at a slow rate that decreases northward to zero. We find a constant northward margin-parallel translation of up to 5 mm/year from northern Vancouver Island extending to Alaska. The southern limit of this translation coincides with areas of high heat flow that may reflect extension and the northern limit of episodic tremor and slip (ETS) on the Cascadia megathrust. The origin of the northward translation is poorly understood. We find a mainland coastal shear zone extends as far south as northern Vancouver Island where the offshore plate boundary is likely subduction. The pattern of the observed coastal shear cannot reflect interseismic locking on a major offshore transcurrent fault. The geodetically determined mainland coastal zone velocities decrease landward from 5 to 0 mm/yr across a region where no active faults have been identified and there is very little current seismicity. In Haida Gwaii, oblique convergence is apparent in the GPS data, consistent with partitioning between margin-parallel and margin-perpendicular strain. After removing the margin parallel translation from the data, we determine an average maximum locking depth of 15 km for the Queen Charlotte transcurrent fault, consistent with seismicity and seismic structure data.

Therapeutic and prognostic value of modal number of chromosomes at the blastic phase of Philadelphia-chromosome-positive chronic myeloid leukemia: comparison based on the same criteria between Nagasaki University and Roswell Park Memorial Institute.

PubMed

Sadamori, N; Yao, E; Mine, M; Tokunaga, S; Matsunaga, M; Nakamura, H; Sasagawa, I; Itoyama, T; Hayashibara, T; Sandberg, A A

1992-01-01

In a comparison of 47 patients with Philadelphia-chromosome (Ph)-positive chronic myeloid leukemia (CML) in the Nagasaki University School of Medicine and 64 patients with the same disease in the Roswell Park Memorial Institute, the correlation between the modal number of chromosomes and the therapeutic response and/or survival after the onset of the blastic phase (BP) was evaluated. The patients were divided into four groups on the basis of the modal number of chromosomes of the cells in the bone marrow: those with hypodiploidy (group 1), those with pseudodiploidy carrying a Ph chromosome (group 2), those with 47 chromosomes (group 3), and those with 48 or more chromosomes (group 4). The results revealed similar trends in the two institutes. Namely, the therapeutic response and the survival after the onset of the BP in groups 1 and 4 were more unfavorable and shorter than those in groups 2 and 3, although the former (group 2) had a better prognosis than the latter (group 3). Thus, the statistical analysis revealed that the numerical chromosome findings at the BP are useful parameters for assessing the therapeutic response and survival after the onset of the BP of CML.

Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and benefits from intrathecal therapy.

PubMed

Martín-Martín, Lourdes; Almeida, Julia; Pomares, Helena; González-Barca, Eva; Bravo, Pilar; Giménez, Teresa; Heras, Cecilia; Queizán, José-Antonio; Pérez-Ceballos, Elena; Martínez, Violeta; Alonso, Natalia; Calvo, Carlota; Álvarez, Rodolfo; Caballero, María Dolores; Orfao, Alberto

2016-03-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive myeloid neoplasm which shows a high rate of central nervous system (CNS) recurrence and overall survival (OS) of <1 year. Despite this, screening for CNS involvement is not routinely performed at diagnosis and intrathecal (IT) prophylaxis is not regularly administered in BPDCN. Here, we prospectively evaluated 13 consecutive BPDCN patients for the presence of CNS involvement by flow cytometry. Despite none of the patients presented with neurological symptoms, occult CNS involvement was detected in 6/10 cases evaluated at diagnosis and 3/3 studied at relapse/progression. BPDCN patients evaluated at diagnosis received IT treatment -either CNS prophylaxis (n = 4) or active therapy (n = 6)- and all but one remain alive (median follow-up of 20 months). In contrast, all three patients assessed at relapse/progression died. The potential benefit of IT treatment administered early at diagnosis on OS and CNS recurrence-free survival of BPDCN was further confirmed in a retrospective cohort of another 23 BPDCN patients. Our results show that BPDCN patients studied at diagnosis frequently display occult CNS involvement; moreover, they also indicate that treatment of occult CNS disease might lead to a dramatically improved outcome of BPDCN.

Classification and clinical behavior of blastic plasmacytoid dendritic cell neoplasms according to their maturation-associated immunophenotypic profile

PubMed Central

Martín-Martín, Lourdes; López, Antonio; Vidriales, Belén; Caballero, María Dolores; Rodrigues, António Silva; Ferreira, Silvia Inês; Lima, Margarida; Almeida, Sérgio; Valverde, Berta; Martínez, Pilar; Ferrer, Ana; Candeias, Jorge; Ruíz-Cabello, Francisco; Buadesa, Josefa Marco; Sempere, Amparo; Villamor, Neus

2015-01-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of leukemia/lymphoma, whose diagnosis can be difficult to achieve due to its clinical and biological heterogeneity, as well as its overlapping features with other hematologic malignancies. In this study we investigated whether the association between the maturational stage of tumor cells and the clinico-biological and prognostic features of the disease, based on the analysis of 46 BPDCN cases classified into three maturation-associated subgroups on immunophenotypic grounds. Our results show that blasts from cases with an immature plasmacytoid dendritic cell (pDC) phenotype exhibit an uncommon CD56− phenotype, coexisting with CD34+ non-pDC tumor cells, typically in the absence of extramedullary (e.g. skin) disease at presentation. Conversely, patients with a more mature blast cell phenotype more frequently displayed skin/extramedullary involvement and spread into secondary lymphoid tissues. Despite the dismal outcome, acute lymphoblastic leukemia-type therapy (with central nervous system prophylaxis) and/or allogeneic stem cell transplantation appeared to be the only effective therapies. Overall, our findings indicate that the maturational profile of pDC blasts in BPDCN is highly heterogeneous and translates into a wide clinical spectrum -from acute leukemia to mature lymphoma-like behavior-, which may also lead to variable diagnosis and treatment. PMID:26056082

Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and benefits from intrathecal therapy

PubMed Central

Martín-Martín, Lourdes; Almeida, Julia; Pomares, Helena; González-Barca, Eva; Bravo, Pilar; Giménez, Teresa; Heras, Cecilia; Queizán, José-Antonio; Pérez-Ceballos, Elena; Martínez, Violeta; Alonso, Natalia; Calvo, Carlota; Álvarez, Rodolfo; Caballero, María Dolores; Orfao, Alberto

2016-01-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive myeloid neoplasm which shows a high rate of central nervous system (CNS) recurrence and overall survival (OS) of <1 year. Despite this, screening for CNS involvement is not routinely performed at diagnosis and intrathecal (IT) prophylaxis is not regularly administered in BPDCN. Here, we prospectively evaluated 13 consecutive BPDCN patients for the presence of CNS involvement by flow cytometry. Despite none of the patients presented with neurological symptoms, occult CNS involvement was detected in 6/10 cases evaluated at diagnosis and 3/3 studied at relapse/progression. BPDCN patients evaluated at diagnosis received IT treatment -either CNS prophylaxis (n = 4) or active therapy (n = 6)- and all but one remain alive (median follow-up of 20 months). In contrast, all three patients assessed at relapse/progression died. The potential benefit of IT treatment administered early at diagnosis on OS and CNS recurrence-free survival of BPDCN was further confirmed in a retrospective cohort of another 23 BPDCN patients. Our results show that BPDCN patients studied at diagnosis frequently display occult CNS involvement; moreover, they also indicate that treatment of occult CNS disease might lead to a dramatically improved outcome of BPDCN. PMID:26840087

[Acute myeloid leukemia possibly originating from the same clone of testicular germ cell tumor].

PubMed

Suyama, Takuya; Obara, Naoshi; Kawai, Koji; Yamada, Kenji; Kusakabe, Manabu; Kurita, Naoki; Nishikii, Hidekazu; Yokoyama, Yasuhisa; Suzukawa, Kazumi; Hasegawa, Yuichi; Noguchi, Masayuki; Chiba, Shigeru

2013-08-01

This report describes a 30-year-old man with a testicular germ cell tumor, which later developed into acute myeloid leukemia (AML) with a common chromosomal abnormality. Testicular germ cell tumors had developed at the age of 26. He was successfully treated with surgery followed by chemotherapy.Four years after the onset of the germ cell tumor, he developed pancytopenia with elevated serum LDH. More than 95% of the bone marrow was occupied by blastic cells. These cells were CD13+, CD34+ but CD45- and MPO-. Amplification of the short arm of chromosome 12 was recognized by fluorescence in situ hybridization using the blastic cells in the bone marrow and the previous testicular tumor specimen. Because testicular germ cell tumor recurrence and other malignant tumors could be ruled out pathologically, he was diagnosed as having AML.Allogeneic stem cell transplantation from a HLA-matched sibling donor was performed after chemotherapy. As of 19 months after the transplantation, recurrence of neither AML nor testicular tumors has been observed. Because the same genetic abnormality was observed in the testicular germ cell tumor and AML in this case, the possibility of AML having a common origin with the testicular germ cell tumor is indicated.

Identifying active interplate and intraplate fault zones in the western Caribbean plate from seismic reflection data and the significance of the Pedro Bank fault zone in the tectonic history of the Nicaraguan Rise

NASA Astrophysics Data System (ADS)

Ott, B.; Mann, P.

2015-12-01

The offshore Nicaraguan Rise in the western Caribbean Sea is an approximately 500,000 km2 area of Precambrian to Late Cretaceous tectonic terranes that have been assembled during the Late Cretaceous formation of the Caribbean plate and include: 1) the Chortis block, a continental fragment; 2) the Great Arc of the Caribbean, a deformed Cretaceous arc, and 3) the Caribbean large igneous province formed in late Cretaceous time. Middle Eocene to Recent eastward motion of the Caribbean plate has been largely controlled by strike-slip faulting along the northern Caribbean plate boundary zone that bounds the northern margin of the Nicaraguan Rise. These faults reactivate older rift structures near the island of Jamaica and form the transtensional basins of the Honduran Borderlands near Honduras. Recent GPS studies suggest that small amount of intraplate motion within the current margin of error of GPS measurements (1-3 mm/yr) may occur within the center of the western Caribbean plate at the Pedro Bank fault zone and Hess Escarpment. This study uses a database of over 54,000 km of modern and vintage 2D seismic data, combined with earthquake data and results from previous GPS studies to define the active areas of inter- and intraplate fault zones in the western Caribbean. Intraplate deformation occurs along the 700-km-long Pedro Bank fault zone that traverses the center of the Nicaraguan Rise and reactivates the paleo suture zone between the Great Arc of the Caribbean and the Caribbean large igneous province. The Pedro Bank fault zone also drives active extension at the 200-km-long San Andres rift along the southwest margin of the Nicaraguan Rise. Influence of the Cocos Ridge indentor may be contributing to reactivation of faulting along the southwesternmost, active segment of the Hess Escarpment.

MIZEX (Marginal Ice Zone Program): A Program for Mesoscale Air-Ice-Ocean Interaction Experimemts om Arctic Marginal Ice Zones. V. MIZEX 84. Summer Experiment PI (Principal Investigator) Preliminary Reports,

DTIC Science & Technology

1984-10-01

164 W.O. Smith, L.A. Codispoti and S.L. Smith Biological Production ................................................. 168 H.-J. Neubert ...in the vicinity of the Kvit Bj orn. 78 Ii The MIZEX-84 High Frequency Accelerometer Study Paul K. Becker and Seelye Martin The field portion of the...w,-9 tested. 4 Natural Tritium Content Hanns-J. Neubert * ~ At station no. 333 (see Fiq.) a hole of’ >7000 m was f’ound. To qet inf’ormation about

MIZEX: A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. MIZEX Bulletin VII.

DTIC Science & Technology

1986-03-01

8217 ILI L2.2363 31-25 UICRQCCW p O TEST C4ART’OPSMa, -f AoA IV 4 86 9 ’ 5 MIZEX BULLETIN SERIES: INFORMATION FOR CONTRIBUTORS The main purpose of the...Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones MIZEX BULLETIN VII LEC T E SEP 2 9 1986 ’Jl P March 1986 J A ’QOzltnal OontsSn$ ooLoP...studies in both the northern and southern hemispheres. W.D. HIBLER Ill March 1986 ii CONTENTS* Page P reface

MIZEX: A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. VIII. A Science Plan for a Winter Marginal Ice Zone Experiment in the Fram Strait/Greenland Sea: 1987/89,

DTIC Science & Technology

1986-04-01

forward modeling, with the pa- be telemetered via the ARGOS system for real - rameter changes needed to bring the predictions time evaluation, and the...integrated en ’i- rtinnental measurement svs fern. quisition system to the Winter MIZEX in I-ram To control and direct the experiment, real - time Strait...to measure, under- Electromagnetic sensing via aircraft and satellites stand, and model: will be employed in real time to identify eddy " Changes in

Norwegian remote sensing experiment in a marginal ice zone

USGS Publications Warehouse

Farrelly, B.; Johannessen, J.A.; Svendsen, E.; Kloster, K.; Horjen, I.; Matzler, C.; Crawford, J.; Harrington, R.; Jones, L.; Swift, C.; Delnore, V.E.; Cavalieri, D.; Gloersen, P.; Hsiao, S.V.; Shemdin, O.H.; Thompson, T.W.; Ramseier, R.O.; Johannessen, O.M.; Campbell, W.J.

1983-01-01

The Norwegian Remote Sensing Experiment in the marginal ice zone north of Svalbard took place in fall 1979. Coordinated passive and active microwave measurements were obtained from shipborne, airborne, and satellite instruments together with in situ observations. The obtained spectra of emissivity (frequency range, 5 to 100 gigahertz) should improve identification of ice types and estimates of ice concentration. Mesoscale features along the ice edge were revealed by a 1.215-gigahertz synthetic aperture radar. Ice edge location by the Nimbus 7 scanning multichannel microwave radiometer was shown to be accurate to within 10 kilometers.

[Salmon-pink colored conjunctival tumor with amyloid deposits].

PubMed

Müller, P L; Loeffler, K U; Holz, F G; Fischer, H-P; Herwig, M C

2016-07-01

An 82-year-old male patient presented with a salmon-pink colored conjunctival tumor of the left eye. A circumscribed, dense and whitish portion was detected by clinical examination. The histophological and immunhistochemical examination of the biopsy tissue revealed a CD20+ marginal zone lymphoma of the conjunctiva with amyloid deposits. Extranodal marginal zone lymphoma at this site is the most common lymphoma of the ocular adnexa and accounts for 5-10% of malignant diseases. An association with amyloid production is very rare and according to the current state of knowledge has no known impact on the outcome.

Anomalous Accretionary Margin Topography Formed By Repeated Earthquakes

NASA Astrophysics Data System (ADS)

Furlong, Kevin P.

2014-05-01

It has long been recognized that accretionary margins of major subduction zones undergo substantial deformation. However even with the large amounts of shortening accommodated within the margin, for most subduction zones, there is an extended submarine portion to the accretionary, highly-deformed upper-plate between the trench and the coast. This is a vexing situation since this submarine section typically overlies the actual locked or coupled patch of the plate interface. The result of this is added difficulty in directly observing processes related to the plate interface coupling - such processes as micro-seismicity and the actual patterns of plate coupling. There are a few locations globally in which there are sub-aerially exposed terranes that lie closer to the trench and overlie the inferred coupled or seismogenic portion of the plate interface. Such regions have taken on significance in subduction zone studies as they provide locations to observe the plate interface coupling effects in the near-field. In particular the Pacific coast of Costa Rica provides such a location, and there has been substantial geologic, geophysical, and geodetic research exploiting the positions of these near-trench peninsulas (Nicoya, Osa, and Burica). These sites provide near-field access to plate-interface processes, but whether they represent typical subduction zone behavior remains an open question as the deformational processes or inherited structures that have produced this anomalous topography are not well constrained. Simply put, if the existence of these sub-aerial, near-trench terranes is a result of anomalous behavior on the plate interface (as has been suggested), then their utility in providing high-fidelity near-field insight into the plate interface properties and processes is substantially reduced. Here we propose a new mechanism that could be responsible for the formation of both the Nicoya and Osa Peninsulas in the past, and is currently producing a third peninsula - the Burica Peninsula at the intersection of the Panama fracture zone and the margin. Specifically we propose that the anomalous topography along the Pacific coast of Costa Rica has been produced by repeated, great subduction earthquakes that have ruptured across the boundary separating the Cocos and Nazca plates - the subducted continuation of the Panama fracture zone. The pattern of upper-plate shortening generated by such a process (documented in the 2007 Mw 8.1 Solomon Islands earthquake, which produced co-seismic localized uplift above the subducted transform plate boundary) convolved with the migration history of the Panama triple junction (PTJ) is proposed as the mechanism to produce substantial along-margin, long-lived accretionary margin topography. Specifically we argue that repeated great subduction earthquakes that rupture across fundamental plate boundary structures can produce substantial, long-lived upper plate deformation above the inter-seismically coupled plate interface.

Wave evolution in the marginal ice zone - Model predictions and comparisons with on-site and remote data

NASA Technical Reports Server (NTRS)

Liu, A. K.; Holt, B.; Vachon, P. W.

1989-01-01

The ocean-wave dispersion relation and viscous attenuation by a sea ice cover were studied for waves in the marginal ice zone (MIZ). The Labrador ice margin experiment (Limex), conducted off the east coast of Newfoundland, Canada in March 1987, provided aircraft SAR, wave buoy, and ice property data. Based on the wave number spectrum from SAR data, the concurrent wave frequency spectrum from ocean buoy data, and accelerometer data on the ice during Limex '87, the dispersion relation has been derived and compared with the model. Accelerometers were deployed at the ice edge and into the ice pack. Data from the accelerometers were used to estimate wave energy attenuation rates and compared with the model. The model-data comparisons are reasonably good for the ice conditions observed during Limex' 87.

Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders

ClinicalTrials.gov

2017-11-29

Accelerated Phase Chronic Myelogenous Leukemia; Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Aplastic Anemia; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Fanconi Anemia; Juvenile Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Paroxysmal Nocturnal Hemoglobinuria; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Waldenström Macroglobulinemia

Metal Deposition Along the Peru Margin Since the Last Glacial Maximum: Evidence For Regime Change at \\sim 6ka

NASA Astrophysics Data System (ADS)

Tierney, J.; Cleaveland, L.; Herbert, T.; Altabet, M.

2004-12-01

The Peru Margin upwelling zone plays a key role in regulating marine biogeochemical cycles, particularly the fate of nitrate. High biological productivity and low oxygen waters fed into the oxygen minimum zone result in intense denitrification in the modern system, the consequences of which are global in nature. It has been very difficult, however, to study the paleoclimatic history of this region because of the poor preservation of carbonate in Peru Margin sediments. Here we present records of trace metal accumulation from two cores located in the heart of the suboxic zone off the central Peru coast. Chronology comes from multiple AMS 14C dates on the alkenone fraction of the sediment, as well as correlation using major features of the \\delta 15N record in each core. ODP Site 1228 provides a high resolution, continuous sediment record from the Recent to about 14ka, while gravity core W7706-41k extends the record to the Last Glacial Maximum. Both cores were sampled at a 100 yr resolution, then analyzed for % N, \\delta 15N, alkenones, and trace metal concentration. Analysis of redox-sensitive metals (Mo and V) alongside metals associated with changes in productivity (Ni and Zn) provides perspective on the evolution of the upwelling system and distinguishes the two major factors controlling the intensity of the oxygen minimum zone. The trace metal record exhibits a notable increase in the intensity and variability of low oxygen waters and productivity beginning around 6ka and extending to the present. Within this most recent 6ka interval, the data suggest fluctuations in oxygenation and productivity occur on 1000 yr timescales. Our core records, therefore, suggest that the Peru Margin upwelling system strengthened significantly during the mid to late Holocene.

Origin of a crustal splay fault and its relation to the seismogenic zone and underplating at the erosional north Ecuador-south Colombia oceanic margin

NASA Astrophysics Data System (ADS)

Collot, J.-Y.; Agudelo, W.; Ribodetti, A.; Marcaillou, B.

2008-12-01

Splay faults within accretionary complexes are commonly associated with the updip limit of the seismogenic zone. Prestack depth migration of a multichannel seismic line across the north Ecuador-south Colombia oceanic margin images a crustal splay fault that correlates with the seaward limit of the rupture zone of the 1958 (Mw 7.7) tsunamogenic subduction earthquake. The splay fault separates 5-6.6 km/s velocity, inner wedge basement rocks, which belong to the accreted Gorgona oceanic terrane, from 4 to 5 km/s velocity outer wedge rocks. The outer wedge is dominated by basal tectonic erosion. Despite a 3-km-thick trench fill, subduction of 2-km-high seamount prevented tectonic accretion and promotes basal tectonic erosion. The low-velocity and poorly reflective subduction channel that underlies the outer wedge is associated with the aseismic, décollement thrust. Subduction channel fluids are expected to migrate upward along splay faults and alter outer wedge rocks. Conversely, duplexes are interpreted to form from and above subducting sediment, at ˜14- to 15-km depths between the overlapping seismogenic part of the splay fault and the underlying aseismic décollement. Coeval basal erosion of the outer wedge and underplating beneath the apex of inner wedge control the margin mass budget, which comes out negative. Intraoceanic basement fossil listric normal faults and a rift zone inverted in a flower structure reflect the evolution of the Gorgona terrane from Cretaceous extension to likely Eocene oblique compression. The splay faults could have resulted from tectonic inversion of listric normal faults, thus showing how inherited structures may promote fluid flow across margin basement and control seismogenesis.

Combination of hand-held probe and microscopy for fluorescence guided surgery in the brain tumor marginal zone.

PubMed

Richter, Johan C O; Haj-Hosseini, Neda; Hallbeck, Martin; Wårdell, Karin

2017-06-01

Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-microscope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection. Eighteen operations were performed on 16 patients with suspected high-grade glioma. The HHF-probe and the FGR-microscope were used for detection of protoporphyrin (PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA) and evaluated against histopathological analysis and visual grading done through the FGR-microscope by the surgeon. A ratio of PpIX fluorescence intensity to the autofluorescence intensity (fluorescence ratio) was used to quantify the spectra detected by the probe. Fluorescence ratio medians (range 0 - 40) measured by the probe were related to the intensity of the fluorescence in the FGR-microscope, categorized as "none" (0.3, n=131), "weak" (1.6, n=34) and "strong" (5.4, n=28). Of 131 "none" points in the FGR-microscope, 88 (67%) exhibited fluorescence with the HHF-probe. For the tumor marginal zone, the area under the receiver operator characteristics (ROC) curve was 0.49 for the FGR-microscope and 0.65 for the HHF-probe. The probe was integrated in the established routine of tumor resection using the FGR-microscope. The HHF-probe was superior to the FGR-microscope in sensitivity; it detected tumor remnants after debulking under the FGR-microscope. The combination of the HHF-probe and the FGR-microscope was beneficial especially in the tumor marginal zone. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients.

PubMed

Servitje, Octavio; Muniesa, Cristina; Benavente, Yolanda; Monsálvez, Verónica; Garcia-Muret, M Pilar; Gallardo, Fernando; Domingo-Domenech, Eva; Lucas, Anna; Climent, Fina; Rodriguez-Peralto, Jose L; Ortiz-Romero, Pablo L; Sandoval, Juan; Pujol, Ramon M; Estrach, M Teresa

2013-09-01

Primary cutaneous marginal zone B-cell lymphomas are low-grade lymphomas running an indolent course. Skin relapses have been frequently reported but little information about disease-free survival (DFS) is available. We sought to evaluate relapse rate and DFS in patients with primary cutaneous marginal zone B-cell lymphomas. Clinical features, European Organization for Research and Treatment of Cancer/International Society for Cutaneous Lymphomas stage, light chain restriction, clonality, treatments, skin relapses, DFS, stage progression, extracutaneous disease, and outcome are analyzed in a series of 137 patients. Patients were classified as solitary lesion (T1) (n = 70; 51%), regional skin involvement (T2) (n = 40; 29%), and generalized skin lesions (T3) (n = 27; 20%). Surgical excision, local radiotherapy, or a combination were the initial treatment in 118 patients (86%). In 121 of 137 patients (88%) a complete remission was observed after initial treatment, including 99 of 106 patients (93%) with solitary or localized disease and 22 of 31 patients (71%) with multifocal lesions. Cutaneous relapses were observed in 53 patients (44%). Median DFS was 47 months. Patients with multifocal lesions or T3 disease showed higher relapse rate and shorter DFS. No significant differences were observed between surgery and radiotherapy, but surgery alone was associated with more recurrences at initial site. Overall survival at 5 and 10 years was 93%. Six patients (4%) developed extracutaneous disease during follow-up. This was a case series retrospective study. Our results support long-term follow-up in patients with primary cutaneous marginal zone B-cell lymphomas. Disseminated skin lesions have higher relapse rate and shorter DFS suggesting further investigation on systemic therapies in such a group of patients. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Volatiles and Fluids in Subduction Zones: Climate Feedback and Trigger Mechanisms for Natural Disasters. An Overview of the Activities of SFB 574.

NASA Astrophysics Data System (ADS)

Reston, T. J.

2005-12-01

The special research program SFB 574 at the University of Kiel investigates the role of fluid and volatile recycling in subduction zones along the Central American convergent margin (Guatemala to Panama) through integrated geophysical, geological, volcanological, geochemical, petrological and oceanographic studies. The work is carried out by over 50 scientists within 12 focussed scientific projects, evenly distributed between the tectonics of the subduction zone, the dewatering through the forearc, and the transfer of fluids from the slab to the atmosphere through the arc. During Phase I (2001-2004), we concentrated on a segment of the erosive subduction zone system onshore and offshore Costa Rica and Nicaragua, one of the focus areas for the MARGIN initiatives SubFac and SEIZE. Along this margin, the dip of subduction, the nature of the incoming plate, and magmatic compositions along the volcanic arc are all known to change significantly. In addition to work carried out during cruises and fieldwork from the 1990s, in the past 4 years we have collected new data during a total 10 months of shiptime on the research vessels SONNE and METEOR, and during 20 man-months of fieldwork, mainly in Costa Rica and Nicaragua. In Phase II (2004-2008) we will finish work off Central America, and start working in an accretionary segment of the Chile margin between 32 and 38S. In this presentation I outline some of the main results concentrating on the effect of variable input and on the output at the arc. Key effects include the influence of the Galapagos hotspot on the incoming section (and on the output at the arc), the thickness of the volcanic crust and the effects of mantle serpentinization.

Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

ClinicalTrials.gov

2017-10-09

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); B-cell Chronic Lymphocytic Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Childhood Renal Cell Carcinoma; Chronic Phase Chronic Myelogenous Leukemia; Clear Cell Renal Cell Carcinoma; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Splenic Marginal Zone Lymphoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer; T-cell Large Granular Lymphocyte Leukemia; Type 1 Papillary Renal Cell Carcinoma; Type 2 Papillary Renal Cell Carcinoma; Waldenström Macroglobulinemia

Circum-Pacific accretion of oceanic terranes to continental blocks: accretion of the Early Permian Dun Mountain ophiolite to the E Gondwana continental margin, South Island, New Zealand

NASA Astrophysics Data System (ADS)

Robertson, Alastair

2016-04-01

Accretionary orogens, in part, grow as a result of the accretion of oceanic terranes to pre-existing continental blocks, as in the circum-Pacific and central Asian regions. However, the accretionary processes involved remain poorly understood. Here, we consider settings in which oceanic crust formed in a supra-subduction zone setting and later accreted to continental terranes (some, themselves of accretionary origin). Good examples include some Late Cretaceous ophiolites in SE Turkey, the Jurassic Coast Range ophiolite, W USA and the Early Permian Dun Mountain ophiolite of South Island, New Zealand. In the last two cases, the ophiolites are depositionally overlain by coarse clastic sedimentary rocks (e.g. Permian Upukerora Formation of South Island, NZ) that then pass upwards into very thick continental margin fore-arc basin sequences (Great Valley sequence, California; Matai sequence, South Island, NZ). Field observations, together with petrographical and geochemical studies in South Island, NZ, summarised here, provide evidence of terrane accretion processes. In a proposed tectonic model, the Early Permian Dun Mountain ophiolite was created by supra-subduction zone spreading above a W-dipping subduction zone (comparable to the present-day Izu-Bonin arc and fore arc, W Pacific). The SSZ oceanic crust in the New Zealand example is inferred to have included an intra-oceanic magmatic arc, which is no longer exposed (other than within a melange unit in Southland), but which is documented by petrographic and geochemical evidence. An additional subduction zone is likely to have dipped westwards beneath the E Gondwana margin during the Permian. As a result, relatively buoyant Early Permian supra-subduction zone oceanic crust was able to dock with the E Gondwana continental margin, terminating intra-oceanic subduction (although the exact timing is debatable). The amalgamation ('soft collision') was accompanied by crustal extension of the newly accreted oceanic slab, and also resulted in the formation of the overlying Maitai continental margin fore-arc basin (possibly related to rollback or a decrease in dip of the remaining subduction zone).Very coarse clastic material (up to ca. 700 m thick) including detached blocks of basaltic and gabbroic rocks, up to tens or metres in size (or more), was shed down fault scarps from relatively shallow water into a deeper water setting by gravity flow processes, ranging from rock fall, to debris flow, to turbidity currents. In addition, relatively fine-grained volcaniclastic-terrigenous sediment was input from an E Gondwana continental margin arc in the form of distal gravity flows, as indicated by geochemical data (e.g. Rare Earth Element analysis of sandstones and shales). The lowest part of the overlying Maitai fore-arc sequence in some areas is represented by hundreds of metres-thick sequences of mixed carbonate-volcaniclastic-terrigenous gravity flows (Wooded Peak Fm.), which are interpreted to have been derived from the E Gondwana continental margin and which finally accumulated in fault-controlled depocentres. Input of shallow-water carbonate material later waned and the Late Permian-Triassic Maitai fore-arc basin was dominated by gravity flows that were largely derived from a contemporaneous continental margin arc (partially preserved in present SE Australia). Subsequent tectonic deformation included on-going subduction, strike-slip and terrane accretion. The sedimentary covers of comparable accreted ophiolites elsewhere (e.g. Coast Range ophiolite, California) may reveal complementary evidence of fundamental terrane accretion processes. Acknowledgements: Hamish Campbell, Dave Craw, Mike Johnson, Chuck Landis, Nick Mortimer, Dhana Pillai and other members of the South Island geological research community

Heat flow in eastern Egypt - The thermal signature of a continental breakup

NASA Technical Reports Server (NTRS)

Morgan, P.; Boulos, F. K.; Hennin, S. F.; El-Sherif, A. A.; El-Sayed, A. A.

1985-01-01

It is noted that the Red Sea is a modern example of continental fragmentation and incipient ocean formation. A consistent pattern of high heat flow in the Red Sea margins and coastal zone, including Precambrian terrane up to at least 30 km from the Red Sea, has emerged from the existing data. It is noted that this pattern has important implications for the mode and mechanism of Red Sea opening. High heat flow in the Red Sea shelf requires either a high extension of the crust in this zone (probably with major basic magmatic activity) or young oceanic crust beneath this zone. High heat flow in the coastal thermal anomaly zone may be caused by lateral conduction from the offshore lithosphere and/or from high mantle heat flow. It is suggested that new oceanic crust and highly extended continental crust would be essentially indistinguishable with the available data in the Red Sea margins, and are for many purposes essentially identical.

Habitable Zone Evolution

NASA Astrophysics Data System (ADS)

Waltham, D.; Lota, J.

2012-12-01

The location of the habitable zone around a star depends upon stellar luminosity and upon the properties of a potentially habitable planet such as its mass and near-surface volatile inventory. Stellar luminosity generally increases as a star ages whilst planetary properties change through time as a consequence of biological and geological evolution. Hence, the location of the habitable zone changes through time as a result of both stellar evolution and planetary evolution. Using the Earth's Phanerozoic temperature history as a constraint, it is shown that changes in our own habitable zone over the last 540 My have been dominated by planetary evolution rather than solar evolution. Furthermore, sparse data from earlier times suggests that planetary evolution may have dominated habitable zone development throughout our biosphere's history. Hence, the existence of a continuously habitable zone depends upon accidents of complex bio-geochemical evolution more than it does upon relatively simple stellar-evolution. Evolution of the inner margin of the habitable zone through time using three different estimates for climate sensitivity. The dashed line shows a typical predicted evolution assuming this was driven simply by a steady increase in solar luminosity. Solar evolution does not account for the observations. Evolution of the outer margin of the habitable zone through time using three different estimates for climate sensitivity. The dashed line shows a typical predicted evolution assuming this was driven simply by a steady increase in solar luminosity. Solar evolution does not account for the observations.

A possible transoceanic tsunami directed toward the U.S. west coast from the Semidi segment, Alaska convergent margin

USGS Publications Warehouse

von Huene, Roland E.; Miller, John J.; Dartnell, Peter

2016-01-01

The Semidi segment of the Alaska convergent margin appears capable of generating a giant tsunami like the one produced along the nearby Unimak segment in 1946. Reprocessed legacy seismic reflection data and a compilation of multibeam bathymetric surveys reveal structures that could generate such a tsunami. A 200 km long ridge or escarpment with crests >1 km high is the surface expression of an active out-of-sequence fault zone, recently referred to as a splay fault. Such faults are potentially tsunamigenic. This type of fault zone separates the relatively rigid rock of the margin framework from the anelastic accreted sediment prism. Seafloor relief of the ridge exceeds that of similar age accretionary prism ridges indicating preferential slip along the splay fault zone. The greater slip may derive from Quaternary subduction of the Patton Murray hot spot ridge that extends 200 km toward the east across the north Pacific. Estimates of tsunami repeat times from paleotsunami studies indicate that the Semidi segment could be near the end of its current inter-seismic cycle. GPS records from Chirikof Island at the shelf edge indicate 90% locking of plate interface faults. An earthquake in the shallow Semidi subduction zone could generate a tsunami that will inundate the US west coast more than the 1946 and 1964 earthquakes because the Semidi continental slope azimuth directs a tsunami southeastward.

Plume type ophiolites in Japan, East Russia and Mongolia: Peculiarity of the Late Jurassic examples

NASA Astrophysics Data System (ADS)

Ishiwatari, Akira; Ichiyama, Yuji; Ganbat, Erdenesaikhan

2013-04-01

Dilek and Furnes (2011; GSAB) provided a new comprehensive classification of ophiolites. In addition to the mid-ocean ridge (MOR) and supra-subduction zone (SSZ) types that are known for decades, they introduced rift-zone (passive margin) type, volcanic arc (active margin) type, and plume type. The last type is thought to be originated in oceanic large igneous provinces (LIPs; oceanic plateaus), and is preserved in the subduction-accretion complexes in the Pacific margins. The LIP-origin greenstones occur in the Middle Paleozoic (Devonian) accretionary complex (AC) in central Mongolia (Ganbat et al. 2012; AGU abst.). The Late Paleozoic and Mesozoic plume-type ophiolites are abundant in Japan. They are Carboniferous greenstones covered by thick limestone in the Akiyoshi belt (Permian AC, SW Japan; Tatsumi et al., 2000; Geology), Permian greenstones in the Mino-Tamba belt (Jurassic AC, SW Japan; Ichiyama et al. 2008; Lithos), and Late Jurassic-Early Cretaceous greenstone in the Sorachi (Hokkaido; Ichiyama et al, 2012; Geology) and Mikabu (SW Japan; this study) belts. The LIP origin of these greenstones is indicated by abundance of picrite (partly komatiite and meimechite), geochemical features resembling HIMU basalts (e.g. high Nb/Y and Zr/Y) and Mg-rich (up to Fo93) picritic olivines following the "mantle array", suggesting very high (>1600oC) temperature of the source mantle plume. The Sorachi-Mikabu greenstones are characterized by the shorter time interval between magmatism and accretion than the previous ones, and are coeval with the meimechite lavas and Alaskan-type ultramafic intrusions in the Jurassic AC in Sikhote-Alin Mountains of Primorye (E. Russia), that suggest a superplume activity in the subduction zone (Ishiwatari and Ichiyama, 2004; IGR). The Mikabu greenstones extend for 800 km along the Pacific coast of SW Japan, and are characterized by the fragmented "olistostrome" occurrence of the basalts, gabbros and ultramafic cumulate rocks (but no mantle peridotite), suggesting tectonism in a sediment-starved subduction zone or a transform fault zone that transected the thick oceanic LIP crust. The Sorachi greenstones are associated with depleted mantle peridotite, and are covered by the thick Cretaceous turbidite formation (Yezo Group), and Takashima et al. (2002; JAES) concluded the marginal basin origin for the "Sorachi ophiolite". We know that some oceanic LIPs were developed into marginal basins (e.g. Caribbean basin). The Late Jurassic-Early Cretaceous greenstone belts of Japan and eastern Russia may represent relics of a 2000 km-size superplume activity that hit the subduction zone and the adjacent ocean floor in NW Pacific.

Shear deformation in the northeastern margin of the Izu collision zone, central Japan, inferred from GPS observations

NASA Astrophysics Data System (ADS)

Doke, R.; Harada, M.; Miyaoka, K.; Satomura, M.

2016-12-01

The Izu collision zone, which is characterized by the collision between the Izu-Bonin arc (Izu Peninsula) and the Honshu arc (the main island of Japan), is located in the northernmost part of the Philippine Sea (PHS) plate. Particularly in the northeastern margin of the zone, numerous large earthquakes have occurred. To clarify the convergent tectonics of the zone related to the occurrence of these earthquakes, in this study, we performed Global Positioning System (GPS) observations and analysis around the Izu collision zone. Based on the results of mapping the steady state of the GPS velocity and strain rate fields, we verified that there has been wide shear deformation in the northeastern part of the Izu collision zone, which agrees with the maximum shear directions in the left-lateral slip of the active faults in the study area. Based on the relative motion between the western Izu Peninsula and the eastern subducting forearc, the shear zone can be considered as a transition zone affected by both collision and subduction. The Higashi-Izu Monogenic Volcano Group, which is located in the southern part of the shear deformation zone, may have formed as a result of the steady motion of the subducting PHS plate and the collision of the Izu Peninsula with the Honshu arc. The seismic activities in the Tanzawa Mountains, which is located in the northern part of the shear deformation zone, and the eastern part of the Izu Peninsula may be related to the shear deformation zone, because the temporal patterns of the seismic activity in both areas are correlated.

CAD/CAM techniques help in the rebuilding of ideal marginal gingiva contours of anterior maxillary teeth: A case report.

PubMed

Yin, Jiayue; Liu, Dan; Huang, Yuehua; Wu, Lin; Tang, Xiaolin

2017-11-01

"Pink esthetics," which are considered to be as important as "white esthetics," have attracted increasing attention. To date, clinicians rarely have applied computer-aided design and computer-aided manufacturing (CAD/CAM) techniques in the rebuilding of the contour of the marginal gingiva in the esthetic zone. In this case report, the authors describe a female patient who had gingival inflammation and an asymmetrical contour of the marginal gingiva of the anterior maxillary teeth because previously placed ceramic crowns violated the biological width. The authors used a 3-dimensional-printing surgery template to guide precise crown-lengthening surgery to expose subgingival shoulders and to obtain an ideal marginal gingival contour. Then the authors used interim CAD/CAM crowns to induce the growth of the interdental papilla by 0.5 to 1.5 millimeters. Finally, the patient had a symmetrical and well-balanced contour of the marginal gingiva. In addition, the authors reduced the patient's "black triangle" areas to the greatest possible extent. This case report illustrates that CAD/CAM products, including 3-dimensional-printing surgery templates and CAD/CAM interim crowns, are helpful in shaping and rebuilding the ideal contour of the marginal gingiva in the esthetic zone, such as the anterior maxillary teeth. Copyright © 2017 American Dental Association. Published by Elsevier Inc. All rights reserved.

Neotectonic reactivation of shear zones and implications for faulting style and geometry in the continental margin of NE Brazil

NASA Astrophysics Data System (ADS)

Bezerra, F. H. R.; Rossetti, D. F.; Oliveira, R. G.; Medeiros, W. E.; Neves, B. B. Brito; Balsamo, F.; Nogueira, F. C. C.; Dantas, E. L.; Andrades Filho, C.; Góes, A. M.

2014-02-01

The eastern continental margin of South America comprises a series of rift basins developed during the breakup of Pangea in the Jurassic-Cretaceous. We integrated high resolution aeromagnetic, structural and stratigraphic data in order to evaluate the role of reactivation of ductile, Neoproterozoic shear zones in the deposition and deformation of post-rift sedimentary deposits in one of these basins, the Paraíba Basin in northeastern Brazil. This basin corresponds to the last part of the South American continent to be separated from Africa during the Pangea breakup. Sediment deposition in this basin occurred in the Albian-Maastrichtian, Eocene-Miocene, and in the late Quaternary. However, our investigation concentrates on the Miocene-Quaternary, which we consider the neotectonic period because it encompasses the last stress field. This consisted of an E-W-oriented compression and a N-S-oriented extension. The basement of the basin forms a slightly seaward-tilted ramp capped by a late Cretaceous to Quaternary sedimentary cover ~ 100-400 m thick. Aeromagnetic lineaments mark the major steeply-dipping, ductile E-W- to NE-striking shear zones in this basement. The ductile shear zones mainly reactivated as strike-slip, normal and oblique-slip faults, resulting in a series of Miocene-Quaternary depocenters controlled by NE-, E-W-, and a few NW-striking faults. Faulting produced subsidence and uplift that are largely responsible for the present-day morphology of the valleys and tablelands in this margin. We conclude that Precambrian shear zone reactivation controlled geometry and orientation, as well as deformation of sedimentary deposits, until the Neogene-Quaternary.

Active faults and minor plates in NE Asia

NASA Astrophysics Data System (ADS)

Kozhurin, Andrey I.; Zelenin, Egor A.

2014-05-01

Stated nearly 40 yr ago the uncertainty with plate boundaries location in NE Asia (Chapman, Solomon, 1976) still remains unresolved. Based on the prepositions that a plate boundary must, first, reveal itself in linear sets of active structures, and, second, be continuous and closed, we have undertaken interpretation of medium-resolution KH-9 Hexagon satellite imageries, mostly in stereoscopic regime, for nearly the entire region of NE Asia. Main findings are as follows. There are two major active fault zones in the region north of the Bering Sea. One of them, the Khatyrka-Vyvenka zone, stretches NE to ENE skirting the Bering Sea from the Kamchatka isthmus to the Navarin Cape. Judging by the kinematics of the Olyutorsky 2006 earthquake fault, the fault zones move both right-laterally and reversely. The second active fault zone, the Lankovaya-Omolon zone, starts close to the NE margin of the Okhotsk Sea and extends NE up to nearly the margin of the Chukcha Sea. The fault zone is mostly right-lateral, with topographically expressed cumulative horizontal offsets amounting to 2.5-2.6 km. There may be a third NE-SW zone between the major two coinciding with the Penzhina Range as several active faults found in the southern termination of the Range indicate. The two active fault zones divide the NE Asia area into two large domains, which both could be parts of the Bering Sea plate internally broken and with uncertain western limit. Another variant implies the Khatyrka-Vyvenka zone as the Bering Sea plate northern limit, and the Lankovaya-Omolon zone as separating an additional minor plate from the North-American plate. The choice is actually not crucial, and more important is that both variants leave the question of where the Bering Sea plate boundary is in Alaska. The Lankovaya-Omolon zone stretches just across the proposed northern boundary of the Okhorsk Sea plate. NW of the zone, there is a prominent left-lateral Ulakhan fault, which is commonly interpreted to be a portion of the plate northern boundary. With this, we have discovered no active faults or fault zones of the Ulakhan fault strike, which could be the portion of the boundary between the Lankovaya-Omolon zone and either the western margin of the Komandor basin or the westernmost Aleutians. We conclude that there is a certain disagreement between active faulting pattern and plate models for NE Asia, relating to the extent of the plates and missing portions of the plate boundaries. The research was supported by grant # 110500136-a from the Russian Foundation for Basic Research.

Aeromagnetic anomaly patterns reveal buried faults along the eastern margin of the Wilkes Subglacial Basin (East Antarctica)

USGS Publications Warehouse

Armadillo, E.; Ferraccioli, F.; Zunino, A.; Bozzo, E.

2007-01-01

The Wilkes Subglacial Basin (WSB) is the major morphological feature recognized in the hinterland of the Transantarctic Mountains. The origin of this basin remains contentious and relatively poorly understood due to the lack of extensive geophysical exploration. We present a new aeromagnetic anomaly map over the transition between the Transantarctic Mountains and the WSB for an area adjacent to northern Victoria Land. The aeromagnetic map reveals the existence of subglacial faults along the eastern margin of the WSB. These inferred faults connect previously proposed fault zones over Oates Land with those mapped along the Ross Sea Coast. Specifically, we suggest a link between the Matusevich Frature Zone and the Priestley Fault during the Cenozoic. The new evidence for structural control on the eastern margin of the WSB implies that a purely flexural origin for the basin is unlikely.

Passive microwave characteristics of the Bering Sea ice cover during Marginal Ice Zone Experiment (MIZEX) West

NASA Technical Reports Server (NTRS)

Cavalieri, D. J.; Gloersen, P.; Wilheit, T. T.; Calhoon, C.

1984-01-01

Passive microwave measurements of the Bering Sea were made with the NASA CV-990 airborne laboratory during February. Microwave data were obtained with imaging and dual-polarized, fixed-beam radiometers in a range of frequencies from 10 to 183 GHz. The high resolution imagery at 92 GHz provides a particularly good description of the marginal ice zone delineating regions of open water, ice compactness, and ice-edge structure. Analysis of the fixed-beam data shows that spectral differences increase with a decrease in ice thickness. Polarization at 18 and 37 GHz distinguishes among new, young, and first-year sea ice types.

Pediatric nodal marginal zone lymphoma may develop in the adult population.

PubMed

Gitelson, Elena; Al-Saleem, Tahseen; Robu, Valentin; Millenson, Michael M; Smith, Mitchell R

2010-01-01

Pediatric nodal marginal zone lymphoma (NMZL) is described as a separate variant of NMZL in the most recent WHO classification of tumors of hematologic and lymphoid tissues. It has distinctive morphology and clinical presentation and stands out as an indolent disease with remarkably better overall prognosis compared to classic NMZL. Here we report two adult patients with NMZL with clinical and morphologic features consistent with pediatric NMZL (pNMZL) and review available literature describing the clinical and histologic presentation of pNMZL. Two men, ages 44 and 18 years, each presented with localized cervical lymphadenopathy, both demonstrated florid proliferation of the marginal zone and disruption of reactive germinal centers, progressive transformation of germinal centers-like morphologic features typical for pNMZL and clonal disease with immunophenotype consistent with NMZL. This is the first report of pNMZL in a middle-aged person. Distinct histologic features and characteristic benign clinical course will help to distinguish this rare variant from other NMZL in the adults. Clinically, recognition is important to understand the true incidence of this rare form in the adult population and to avoid unnecessary overtreatment of this indolent form.

Radiotherapy in marginal zone lymphoma

PubMed Central

2013-01-01

Purpose To evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL). Materials and methods Patients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n = 12), stomach (n = 8), head and neck other than the orbita (n = 8), breast (n = 1) and one case of marginal zone lymphoma of the skin (n = 1). The median radiotherapy dose was 40 Gy (5 to 45 Gy). Results The median follow-up time was 103 months. The 5-year overall survival and event-free survival rates were 85 ± 7% and 71 ± 9%, respectively. There was no infield recurrence. Recurrence occurred outside of the radiation field in six patients. The relapses were treated with salvage RT and had excellent local control (100%) at five years after salvage RT. Conclusions Localized extranodal MZL have an excellent prognosis following moderate-dose RT. RT is also an effective salvage therapy in cases of localized recurrence. Further clinical studies should evaluate the optimal dose for MZL. PMID:23281682

Giant Cell Arteritis of the Female Genital Tract With Occult Temporal Arteritis and Marginal Zone Lymphoma Harboring Novel 20q Deletion: A Case Report and Literature Review.

PubMed

Pradhan, Dinesh; Amin, Rajnikant M; Jones, Miroslawa W; Surti, Urvashi; Parwani, Anil V

2016-02-01

Giant cell arteritis (GCA) is an immunologically mediated vasculitis of large and medium-sized vessels, typically affecting the cranial arteries and usually occurring in the elderly. GCA of the female genital tract is extremely rare with only 31 cases reported in the English literature. An 83-year-old white female with postmenopausal vaginal bleeding revealed an endometrial polyp on pelvic ultrasonography following which polypectomy and subsequently hysterectomy with bilateral salpingo-oophorectomy was done. Microscopy revealed a well-differentiated endometrioid adenocarcinoma. Interestingly, classic GCA involving numerous small to medium-sized arteries of the cervix, myometrium, bilateral fallopian tubes, and ovaries was also identified. Hematologic evaluation revealed marginal zone lymphoma with an exceptionally rare 20q deletion. Bilateral temporal artery biopsy was done subsequently, which exhibited GCA on microscopy. Corticosteroid was started that improved her polymyalgia rheumatica symptoms. The patient is on follow-up for 3 years and is doing well. To our knowledge, this is the first case of GCA of the female genital tract associated with a lymphoma and the second case of marginal zone lymphoma with the novel 20q deletion. © The Author(s) 2015.

Uppermost mantle velocity from Pn tomography in the Gulf of Aden

NASA Astrophysics Data System (ADS)

Corbeau, Jordane; Rolandone, Frédérique; Leroy, Sylvie; Al-Lazki, Ali; Keir, Derek; Stuart, Graham; Stork, Anna

2013-04-01

We present an analysis of Pn traveltimes to determine lateral variations of velocity in the uppermost mantle and crustal thickness beneath the Gulf of Aden and its margins. No detailed tomographic image of the entire Gulf of Aden was available. Previous tomographic studies covered the eastern Gulf of Aden and were thus incomplete or at a large scale with a too low resolution to see the lithospheric structures. From 1990 to 2010, 49206 Pn arrivals were selected from the International Seismological Center catalogue. We also used temporary networks : YOCMAL (Young Conjugate Margins Laboratory) networks with broadband stations located in Oman, Yemen and Socotra from 2003 to 2011, and Djibouti network from 2009 to 2011. From these networks we picked Pn arrivals and selected 4110 rays. Using a least-squares tomographic code (Hearn, 1996), these data were analyzed to solve for velocity variations in the mantle lithosphere. We perform different inversions for shorter and longer ray path data sets in order to separate the shallow and deep structure within the mantle lid. In the upper lid, zones of low velocity (7.7 km/s) around Sanaa, Aden, Afar, and along the Gulf of Aden are related to active volcanism. Off-axis volcanism and a regional melting anomaly in the Gulf of Aden area may be connected to the Afar plume, and explained by the model of channeling material away from the Afar plume along ridge-axis. Our study validates the channeling model and shows that the influence of the Afar hotspot may extend much farther eastwards along the Aden and Sheba ridges into the Gulf of Aden than previously believed. Still in the upper lid, high Pn velocities (>8,2 km/s) are observed in Yemen and may be related to the presence of a magmatic underplating under the volcanic margin of Aden and under the Red Sea margins. In the lower lid, zones of low velocities are spatially located differently than in the upper lid. On the Oman margin, a low velocity zone (7.6 km/s) suggests deep partial melting. The Pn velocity below Socotra island is slower, whereas a high velocity zone is observed north of the Sheba ridge. The hot material may have flowed through Alula-Fartak transform zone towards Socotra.

AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma

ClinicalTrials.gov

2017-02-21

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Prolymphocytic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

Chile's seismogenic coupling zones - geophysical and neotectonic observations from the South American subduction zone prior to the Maule 2010 earthquake

NASA Astrophysics Data System (ADS)

Oncken With Tipteq, Onno; Ipoc Research Groups

2010-05-01

Accumulation of deformation at convergent plate margins is recently identified to be highly discontinuous and transient in nature: silent slip events, non-volcanic tremors, afterslip, fault coupling and complex response patterns of the upper plate during a single event as well as across several seismic cycles have all been observed in various settings and combinations. Segments of convergent plate margins with high recurrence rates and at different stages of the rupture cycle like the Chilean margin offer an exceptional opportunity to study these features and their interaction resolving behaviour during the seismic cycle and over repeated cycles. A past (TIPTEQ) and an active international initiative (IPOC; Integrated Plate Boundary Observatory Chile) address these goals with research groups from IPG Paris, Seismological Survey of Chile, Free University Berlin, Potsdam University, Hamburg University, IFM-GEOMAR Kiel, and GFZ Potsdam employing an integrated plate boundary observatory and associated projects. We focus on the south Central Chilean convergent margin and the North Chilean margin as natural laboratories embracing the recent Maule 2010 megathrust event. Here, major recent seismic events have occurred (south Central Chile: 1960, Mw = 9.5; 2010, Mw = 8.8; North Chile: 1995, Mw = 8; 2001, Mw = 8.7; 2007, Mw: 7.8) or are expected in the very near future (Iquique, last ruptured 1877, Mw = 8.8) allowing observation at critical time windows of the seismic cycle. Seismic imaging and seismological data have allowed us to relocate major rupture hypocentres and to locate the geometry of the locked zone and the degree of locking in both areas. The reflection seismic data exhibit well defined changes of reflectivity and Vp/Vs ratio along the plate interface that can be correlated with different parts of the coupling zone as well as with changes during the seismic cycle. Observations suggest an important role of the hydraulic system, an inference that is strongly supported from recent findings along the exhumed, fossil seismogenic coupling zone of the European Alps. The data provide additional evidence that the degree of interseismic locking is closely mirrored by subsequent megathrust failure as evidenced by the slip and aftershock pattern of the Maule 2010 earthquake. Neogene surface deformation in Chile has been complex exhibiting tectonically uplifting areas along the coast driven by interseismically active reverse faulting. In addition, we observe coseismically subsiding domains along other parts of the coast. Moreover, the coseismic and interseismic vertical displacement identified is not coincident with long-term vertical motion that probably is superseded by slow basal underplating or tectonic erosion occurring at the downdip parts of the seismogenic zone causing discontinuous uplift. Analogue and numerical modelling lend additional support to the kinematic patterns linking slip at the seismogenic coupling zone and upper plate response. Finally we note that the characteristic peninsulas along the South American margin constitute stable rupture boundaries/barriers and appear to have done so for a protracted time as evidenced by their long-term uplift history since at least the Late Pliocene that points to anomalous properties of the plate interface affecting the mode of strain accumulation and plate interface rupture.

Fault evolution in the Potiguar rift termination, equatorial margin of Brazil

NASA Astrophysics Data System (ADS)

de Castro, D. L.; Bezerra, F. H. R.

2015-02-01

The transform shearing between South American and African plates in the Cretaceous generated a series of sedimentary basins on both plate margins. In this study, we use gravity, aeromagnetic, and resistivity surveys to identify architecture of fault systems and to analyze the evolution of the eastern equatorial margin of Brazil. Our study area is the southern onshore termination of the Potiguar rift, which is an aborted NE-trending rift arm developed during the breakup of Pangea. The basin is located along the NNE margin of South America that faces the main transform zone that separates the North and the South Atlantic. The Potiguar rift is a Neocomian structure located at the intersection of the equatorial and western South Atlantic and is composed of a series of NE-trending horsts and grabens. This study reveals new grabens in the Potiguar rift and indicates that stretching in the southern rift termination created a WNW-trending, 10 km wide, and ~ 40 km long right-lateral strike-slip fault zone. This zone encompasses at least eight depocenters, which are bounded by a left-stepping, en echelon system of NW-SE- to NS-striking normal faults. These depocenters form grabens up to 1200 m deep with a rhomb-shaped geometry, which are filled with rift sedimentary units and capped by postrift sedimentary sequences. The evolution of the rift termination is consistent with the right-lateral shearing of the equatorial margin in the Cretaceous and occurs not only at the rift termination but also as isolated structures away from the main rift. This study indicates that the strike-slip shearing between two plates propagated to the interior of one of these plates, where faults with similar orientation, kinematics, geometry, and timing of the major transform are observed. These faults also influence rift geometry.

Subduction-driven recycling of continental margin lithosphere.

PubMed

Levander, A; Bezada, M J; Niu, F; Humphreys, E D; Palomeras, I; Thurner, S M; Masy, J; Schmitz, M; Gallart, J; Carbonell, R; Miller, M S

2014-11-13

Whereas subduction recycling of oceanic lithosphere is one of the central themes of plate tectonics, the recycling of continental lithosphere appears to be far more complicated and less well understood. Delamination and convective downwelling are two widely recognized processes invoked to explain the removal of lithospheric mantle under or adjacent to orogenic belts. Here we relate oceanic plate subduction to removal of adjacent continental lithosphere in certain plate tectonic settings. We have developed teleseismic body wave images from dense broadband seismic experiments that show higher than expected volumes of anomalously fast mantle associated with the subducted Atlantic slab under northeastern South America and the Alboran slab beneath the Gibraltar arc region; the anomalies are under, and are aligned with, the continental margins at depths greater than 200 kilometres. Rayleigh wave analysis finds that the lithospheric mantle under the continental margins is significantly thinner than expected, and that thin lithosphere extends from the orogens adjacent to the subduction zones inland to the edges of nearby cratonic cores. Taking these data together, here we describe a process that can lead to the loss of continental lithosphere adjacent to a subduction zone. Subducting oceanic plates can viscously entrain and remove the bottom of the continental thermal boundary layer lithosphere from adjacent continental margins. This drives surface tectonics and pre-conditions the margins for further deformation by creating topography along the lithosphere-asthenosphere boundary. This can lead to development of secondary downwellings under the continental interior, probably under both South America and the Gibraltar arc, and to delamination of the entire lithospheric mantle, as around the Gibraltar arc. This process reconciles numerous, sometimes mutually exclusive, geodynamic models proposed to explain the complex oceanic-continental tectonics of these subduction zones.

The dynamics of continental breakup-related magmatism on the Norwegian volcanic margin

NASA Astrophysics Data System (ADS)

Breivik, A. J.; Faleide, J. I.; Mjelde, R.

2007-12-01

The Vøring margin off mid-Norway was initiated during the earliest Eocene (~54 Ma), and large volumes of magmatic rocks were emplaced during and after continental breakup. In 2003, an ocean bottom seismometer survey was acquired on the Norwegian margin to constrain continental breakup and early seafloor spreading processes. The profile P-wave model described here crosses the northern part of the Vøring Plateau. Maximum igneous crustal thickness was found to be 18 km, decreasing to ~6.5 km over ~6 M.y. after continental breakup. Both the volume and the duration of excess magmatism after breakup is about twice of what is observed off the Møre Margin south of the Jan Mayen Fracture Zone, which offsets the margin segments by ~170 km. A similar reduction in magmatism occurs to the north over an along-margin distance of ~100 km to the Lofoten margin, but without a margin offset. There is a strong correlation between magma productivity and early plate spreading rate, which are highest just after breakup, falling with time. This is seen both at the Møre and the Vøring margin segments, suggesting a common cause. A model for the breakup- related magmatism should be able to (1) explain this correlation, (2) the magma production peak at breakup, and (3) the magmatic segmentation. Proposed end-member hypotheses are elevated upper-mantle temperatures caused by a hot mantle plume, or edge-driven small-scale convection fluxing mantle rocks through the melt zone. Both the average P-wave velocity and the major-element data at the Vøring margin indicate a low degree of melting consistent with convection. However, small scale convection does not easily explain the issues listed above. An elaboration of the mantle plume model by N. Sleep, in which buoyant plume material fills the rift-topography at the base of the lithosphere, can explain these: When the continents break apart, the buoyant plume-material flows up into the rift zone, causing excess magmatism by both elevated temperature and excess flux, and magmatism dies off as this rift-restricted material is spent. The buoyancy of the plume-material also elevates the plate boundaries and enhances plate spreading forces initially. The rapid drop in magma productivity to the north correlates with the northern boundary of the wide and deep Cretaceous Vøring Basin, thus less plume material was accommodated off Lofoten. This model predicts that the magma segmentation will show little variation in the geochemical signature.

Faulting along the southern margin of Reelfoot Lake, Tennessee

USGS Publications Warehouse

Van Arsdale, R.; Purser, J.; Stephenson, W.; Odum, J.

1998-01-01

The Reelfoot Lake basin, Tennessee, is structurally complex and of great interest seismologically because it is located at the junction of two seismicity trends of the New Madrid seismic zone. To better understand the structure at this location, a 7.5-km-long seismic reflection profile was acquired on roads along the southern margin of Reelfoot Lake. The seismic line reveals a westerly dipping basin bounded on the west by the Reelfoot reverse fault zone, the Ridgely right-lateral transpressive fault zone on the east, and the Cottonwood Grove right-lateral strike-slip fault in the middle of the basin. The displacement history of the Reelfoot fault zone appears to be the same as the Ridgely fault zone, thus suggesting that movement on these fault zones has been synchronous, perhaps since the Cretaceous. Since the Reelfoot and Ridgely fault systems are believed responsible for two of the mainshocks of 1811-1812, the fault history revealed in the Reelfoot Lake profile suggests that multiple mainshocks may be typical of the New Madrid seismic zone. The Ridgely fault zone consists of two northeast-striking faults that lie at the base of and within the Mississippi Valley bluff line. This fault zone has 15 m of post-Eocene, up-to-the-east displacement and appears to locally control the eastern limit of Mississippi River migration. The Cottonwood Grove fault zone passes through the center of the seismic line and has approximately 5 m up-to-the-east displacement. Correlation of the Cottonwood Grove fault with a possible fault scarp on the floor of Reelfoot Lake and the New Markham fault north of the lake suggests the Cottonwood Grove fault may change to a northerly strike at Reelfoot Lake, thereby linking the northeast-trending zones of seismicity in the New Madrid seismic zone.

The MIRROR cruise (2011): Deep crustal structure of the Moroccan Atlantic Margin from wide-angle and reflection seismic data

NASA Astrophysics Data System (ADS)

Klingelhoefer, F.; Aslanian, D.; Sahabi, M.; Moulin, M.; Schnurle, P.; Berglar, K.; Biari, Y.; Feld, A.; Graindorge, D.; Corela, C.; Mehdi, K.; Zourarah, B.; Perrot, J.; Alves Ribeiro, J.; Reichert, C. J.

2011-12-01

The study of conjugate margins is important to test different hypotheses of rifting and initial opening of an ocean. In this scope, seven wide-angle seismic profiles were acquired on the Moroccan Atlantic margin (at the latitudes between 32° and 33° N) together with coincident deep frequency reflection seismic data during the MIRROR cruise in May and June 2011. The main seismic profile is conjugate to an existing wide-angle seismic profile off Nova Scotia (SMART 2). Further objectives of the cruise were to image ocean-continent transition zone, to detect and eventually quantify exhumed upper mantle material present in this zone and to determine the origin of the high amplitude West African Magnetic Anomaly, which is conjugate to the north American East Coast Magnetic Anomaly and can be linked to the opening of the Atlantic. Two of the newly acquired profiles are located perpendicular and five parallel to the Moroccan margin. The seismic profiles are between 130 and 260 km in length and between 28 and 13 ocean-bottom seismometers were deployed on each one. One profile was extended on land by 15 landstations in order to better image the zone of continental thinning. A 4.5 km digital streamer and a 7200 cu inch tuned airgun array were used for the acquisition of the seismic data. Additionally magnetic, bathymetric and high resolution seismic data were acquired in the study region. Preliminary results from tomographic inversion of the first arrivals from the ocean-bottom seismometer data image the zone of crustal thinning from about 25 km to 6 km in the basin along about 70 kilometers of the profiles which are located perpendicular to the margin. The oceanic crust can be divided into 2 regions, based on the lower crustal velocities. Upper mantle velocities are about 8.0 km/s. The coincident reflection seismic data show the fine basement and sedimentary structures including salt tectonics in the basin. The comparative study of the two conjugate profiles on the Moroccan and Nova Scotia margin will give new insights into the original opening of the Atlantic ocean. Further work on this data set will include forward modelling of the wide-angle seismic data, gravity and magnetic modelling.

Analysis of Fractal Parameters of the Lunar Surface

NASA Astrophysics Data System (ADS)

Nefedyev, Yuri; Petrova, Natalia; Andreev, Alexey; Demina, Natalya; Demin, Sergey

2016-07-01

Analysis of complex selenographic systems is a complicatedissue. This fully applies to the lunar topography. In this report a new method of the comparative reliable estimation of thelunar mapsdata is represented. The estimation was made by the comparison of high-altitude lines using the fractal analysis. The influence of the lunar macrofigure variances were determined by the method of fractal dimensions comparison. It should be noted the investigations of the lunar figure and rotation implystudy itsmarginal zone charts constructionwith various methods and this is traditionally carried out at the Engelhardt Astronomical Observatory (EAO). In particular this research is important for lunar occultations reductions and on the basis of that it is possible to solve a number of astrometric and astrophysical problems. By now the highly accurate theories of the lunar movement have been obtained and stars coordinates have been determined on the basis of space measurements with the several multiarcseconds accuracy but there are factors highly influencingon the accuracy of the results of these observations. They are: exactitude of the occultation moment recording, errors of the stars coordinates, accuracy of lunar ephemeris positions and unreliability of lunar marginal zone charts. Therefore difficulties arise during the reduction process of lunar occultations by the reason of irregularities of lunar limb. Existing charts of the lunar marginal zone have some defects. The researching of lunar marginal zone maps is very difficult. First of all, it concernsthe reliability of maps data. To resolve this task thecomparison method in which the structure of the high-altitude lines of data appropriated with identical lunar coordinates can used. However, such comparison requires a lot of calculations. In addition there is a large number of the marginal zone maps constructed by different methods and the accuracy of their data causes many questions. In other words, the lunar relief has a very complex structure and traditional research methods are unacceptable. After considering this, it was decided to use the method of fractal dimensionsd comparisons. For this purpose lunar marginal zone maps made in the celestial coordinate system (maps N1) and oneconstructed on the basis of data obtained from heliometric observations with taking into account thefirst model of the figure of the Moon given by Jakovkin (maps N2) were taken. The charts contain isohypses of the lunar marginal zone extending over 10" on both sides of the mean position of the limb line. In order to find thevariations of irregularities for thelimb points above the mean level of lunar surface werecomputed the position angles of this pointsP (reckoned from the centre of the Moon's disc) and D coordinates. This coordinates introduced by Hayn: P is the selenocentric longitude reckoned along the mean limb from the north pole of the Moon, like the position angles, and D is the latitude counted positively for that part of the disc that is nearer to the observer. Thus the data of our studies was obtained by identical types. Then the first, segments of a lunar marginal zone for every 45" on P were considered. For each segment profile of the surface for a constant D were constructed with a step of 2". Thus 80 profiles were obtained. Secondly the fractal dimensions d for each considered structure was defined. Third the obtained values d werecompared with the othersmaps considered in this work. The obtained results show some well agreement between the mean fractal dimensions for maps N1 and N2. Thus it can be concluded that the using of fractal method for lunar maps analysis to determine the accuracy of the presented to themdata give good results. The work was supported by grants RFBR 15-02-01638-a, 16-32-60071-mol-dk-a and 16-02-00496-a.

Elastic thickness estimates at northeast passive margin of North America and its implications

NASA Astrophysics Data System (ADS)

Kumar, R. T. Ratheesh; Maji, Tanmay K.; Kandpal, Suresh Ch; Sengupta, D.; Nair, Rajesh R.

2011-06-01

Global estimates of the elastic thickness (Te) of the structure of passive continental margins show wide and varying results owing to the use of different methodologies. Earlier estimates of the elastic thickness of the North Atlantic passive continental margins that used flexural modelling yielded a Te value of ~20-100 km. Here, we compare these estimates with the Te value obtained using orthonormalized Hermite multitaper recovered isostatic coherence functions. We discuss how Te is correlated with heat flow distribution and depth of necking. The E-W segment in the southern study region comprising Nova Scotia and the Southern Grand Banks show low Te values, while the zones comprising the NE-SW zones, viz., Western Greenland, Labrador, Orphan Basin and the Northern Grand Bank show comparatively high Te values. As expected, Te broadly reflects the depth of the 200-400°C isotherm below the weak surface sediment layer at the time of loading, and at the margins most of the loading occurred during rifting. We infer that these low Te measurements indicate Te frozen into the lithosphere. This could be due to the passive nature of the margin when the loads were emplaced during the continental break-up process at high temperature gradients.

RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors

ClinicalTrials.gov

2014-11-06

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; HER2-negative Breast Cancer; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Male Breast Cancer; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Breast Cancer; Recurrent Colon Cancer; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Rectal Cancer; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Colon Cancer; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Rectal Cancer; Stage III Small Lymphocytic Lymphoma; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Rectal Cancer; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery

ClinicalTrials.gov

2015-06-30

Adult Acute Lymphoblastic Leukemia in Remission; Adult B Acute Lymphoblastic Leukemia; Adult Hepatocellular Carcinoma; Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Adult Solid Neoplasm; Adult T Acute Lymphoblastic Leukemia; Advanced Adult Hepatocellular Carcinoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Localized Non-Resectable Adult Liver Carcinoma; Localized Resectable Adult Liver Carcinoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Progressive Hairy Cell Leukemia Initial Treatment; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Liver Carcinoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; Stage II Small Lymphocytic Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-Cell Leukemia/Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides and Sezary Syndrome; Stage IIIB Mycosis Fungoides and Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-Cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides and Sezary Syndrome; Stage IVB Mycosis Fungoides and Sezary Syndrome; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Hairy Cell Leukemia; Waldenstrom Macroglobulinemia

Asymmetric rifting, breakup and magmatism across conjugate margin pairs: insights from Newfoundland to Ireland

NASA Astrophysics Data System (ADS)

Peace, Alexander L.; Welford, J. Kim; Foulger, Gillian R.; McCaffrey, Ken J. W.

2017-04-01

Continental extension, subsequent rifting and eventual breakup result in the development of passive margins with transitional crust between extended continental crust and newly created oceanic crust. Globally, passive margins are typically classified as either magma-rich or magma-poor. Despite this simple classification, magma-poor margins like the West Orphan Basin, offshore Newfoundland, do exhibit some evidence of localized magmatism, as magmatism to some extent invariably accompanies all continental breakup. For example, on the Newfoundland margin, a small volcanic province has been interpreted near the termination of the Charlie Gibbs Fracture Zone, whereas on the conjugate Irish margin within the Rockall Basin, magmatism appears to be more widespread and has been documented both in the north and in the south. The broader region over which volcanism has been identified on the Irish margin is suggestive of magmatic asymmetry across this conjugate margin pair and this may have direct implications for the mechanisms governing the nature of rifting and breakup. Possible causes of the magmatic asymmetry include asymmetric rifting (simple shear), post-breakup thermal anomalies in the mantle, or pre-existing compositional zones in the crust that predispose one of the margins to more melting than its conjugate. A greater understanding of the mechanisms leading to conjugate margin asymmetry will enhance our fundamental understanding of rifting processes and will also reduce hydrocarbon exploration risk by better characterizing the structural and thermal evolution of hydrocarbon bearing basins on magma-poor margins where evidence of localized magmatism exists. Here, the latest results of a conjugate margin study of the Newfoundland-Ireland pair utilizing seismic interpretation integrated with other geological and geophysical datasets are presented. Our analysis has begun to reveal the nature and timing of rift-related magmatism and the degree to which magmatic asymmetry exists between these conjugate margins. The main implications from this work are that different processes may have operated during and after rifting on these conjugate margins. This concept should be carried forward when conducting conjugate margin studies elsewhere, particularly when exploring for hydrocarbons as prospectivity on one margin may not be predictive for its conjugate as different thermal and structural regimes may have been in operation during conjugate basin evolution.

Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1985. Volume 2,

DTIC Science & Technology

1985-10-01

Objective(s): To study the feasibility of cytosine arabinoside (ara-C), used in high dosage in conjunction with fractionated total body irradiation... Using High Dose Ara-C 335 in Adult Acute Leukemia and Chronic Granulocytic Leukemia in Blastic Crisis, Phase III. (0) SWOG 8328 Evaluation of...Fludarabine Phosphate in Cervical Cancer, 336 Phase II. (0) SWOG 8360 Use of the Surgically Implanted "Infusaid" Pump for Ambula- 337 tory Ottpatient Hepatic

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.

PubMed

Montero, Joan; Stephansky, Jason; Cai, Tianyu; Griffin, Gabriel K; Cabal-Hierro, Lucia; Togami, Katsuhiro; Hogdal, Leah J; Galinsky, Ilene; Morgan, Elizabeth A; Aster, Jon C; Davids, Matthew S; LeBoeuf, Nicole R; Stone, Richard M; Konopleva, Marina; Pemmaraju, Naveen; Letai, Anthony; Lane, Andrew A

2017-02-01

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the antiapoptotic protein BCL2 and were uniformly sensitive to the BCL2 inhibitor venetoclax, as measured by direct cytotoxicity, apoptosis assays, and dynamic BH3 profiling. Animals bearing BPDCN patient-derived xenografts had disease responses and improved survival after venetoclax treatment in vivo Finally, we report on 2 patients with relapsed/refractory BPDCN who received venetoclax off-label and experienced significant disease responses. We propose that venetoclax or other BCL2 inhibitors undergo expedited clinical evaluation in BPDCN, alone or in combination with other therapies. In addition, these data illustrate an example of precision medicine to predict treatment response using ex vivo functional assessment of primary tumor tissue, without requiring a genetic biomarker. Therapy for BPDCN is inadequate, and survival in patients with the disease is poor. We used primary tumor cell functional profiling to predict BCL2 antagonist sensitivity as a common feature of BPDCN, and demonstrated in vivo clinical activity of venetoclax in patient-derived xenografts and in 2 patients with relapsed chemotherapy-refractory disease. Cancer Discov; 7(2); 156-64. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 115. ©2016 American Association for Cancer Research.

The Geodetic Signature of the Earthquake Cycle at Subduction Zones: Model Constraints on the Deep Processes

NASA Astrophysics Data System (ADS)

Govers, R.; Furlong, K. P.; van de Wiel, L.; Herman, M. W.; Broerse, T.

2018-03-01

Recent megathrust events in Tohoku (Japan), Maule (Chile), and Sumatra (Indonesia) were well recorded. Much has been learned about the dominant physical processes in megathrust zones: (partial) locking of the plate interface, detailed coseismic slip, relocking, afterslip, viscoelastic mantle relaxation, and interseismic loading. These and older observations show complex spatial and temporal patterns in crustal deformation and displacement, and significant differences among different margins. A key question is whether these differences reflect variations in the underlying processes, like differences in locking, or the margin geometry, or whether they are a consequence of the stage in the earthquake cycle of the margin. Quantitative models can connect these plate boundary processes to surficial and far-field observations. We use relatively simple, cyclic geodynamic models to isolate the first-order geodetic signature of the megathrust cycle. Coseismic and subsequent slip on the subduction interface is dynamically (and consistently) driven. A review of global preseismic, coseismic, and postseismic geodetic observations, and of their fit to the model predictions, indicates that similar physical processes are active at different margins. Most of the observed variability between the individual margins appears to be controlled by their different stages in the earthquake cycle. The modeling results also provide a possible explanation for observations of tensile faulting aftershocks and tensile cracking of the overriding plate, which are puzzling in the context of convergence/compression. From the inversion of our synthetic GNSS velocities we find that geodetic observations may incorrectly suggest weak locking of some margins, for example, the west Aleutian margin.

Ar-Ar and Rb-Sr dating of very low-/low-grade metamorphism along the main Iapetus suture, Newfoundland

NASA Astrophysics Data System (ADS)

Willner, Arne P.; Glodny, Johannes; Massonne, Hans-Joachim; Romer, Rolf L.; Sudo, Masafumi; Van Staal, Cees R.; Zagorevski, Alexandre

2013-04-01

The Late Ordovician closure of the main tract of Iapetus resulted in juxtaposition of the leading edge of the peri-Gondwanan microplate Ganderia and the composite Laurentian margin. The suture is the Red Indian Line, which separates the Iapetan realm into peri-Gondwanan and peri-Laurentian arc-backarc complexes. The discrete Red Indian Line forms part of a wider collision zone that has a protracted and complicated tectonic history starting with underplating of oceanic terranes beneath the composite margin of Laurentia at ca. 471 Ma during the early stages of the Taconic orogeny. Final collision along the Red Indian Line and closure of the Iapetus ocean occurred at 455 Ma with the underthrusting of the peri-Gondwanan Victoria arc and its Ganderian basement beneath the composite Laurentian margin. The accreted Iapetan realm terranes were progressively deformed during the closure of a remaining Iapetan marginal basin, resulting locally in significant overprint and reactivation during the Silurian (Salinic orogeny). Metamorphic overprint in the deformed Laurentia margin (Notre Dame Zone) above the Red Indian Line is mainly of very low grade to low grade and very heterogeneous. PT-conditions cluster at 3-5 kbar, 300-400°C and 6-7 kbar, 270-330°C. Medium grade conditions are related to local contact metamorphism. Ages of the local peak metamorphism in the peri-Laurentian Iapetan realm were determined by dating white mica with the Ar-Ar system and white mica-bearing assemblages with the Rb-Sr mineral isochron method. Both methods yielded ages that postdate the closure of the main tract of Iapetus. These generally belong to two age ranges: 418-430 Ma (Salinic events) and 350-390 Ma Neoacadian events). Partly two overprints can be detected in one and the same sample. Metamorphism is related to (1) reactivation of deformation in shear zones which partly cause further crustal thickening or strike slip-related deformation, (2) to external fluid influx, (3) to advective heating by synkinematic intrusions or (4) to a combination of these effects. Salinic to Neoacadian postcollisional processes in the collision zone apparently are much more widespread than formerly recognized.

Inverse methods-based estimation of plate coupling in a plate motion model governed by mantle flow

NASA Astrophysics Data System (ADS)

Ratnaswamy, V.; Stadler, G.; Gurnis, M.

2013-12-01

Plate motion is primarily controlled by buoyancy (slab pull) which occurs at convergent plate margins where oceanic plates undergo deformation near the seismogenic zone. Yielding within subducting plates, lateral variations in viscosity, and the strength of seismic coupling between plate margins likely have an important control on plate motion. Here, we wish to infer the inter-plate coupling for different subduction zones, and develop a method for inferring it as a PDE-constrained optimization problem, where the cost functional is the misfit in plate velocities and is constrained by the nonlinear Stokes equation. The inverse models have well resolved slabs, plates, and plate margins in addition to a power law rheology with yielding in the upper mantle. Additionally, a Newton method is used to solve the nonlinear Stokes equation with viscosity bounds. We infer plate boundary strength using an inexact Gauss-Newton method with line search for backtracking. Each inverse model is applied to two simple 2-D scenarios (each with three subduction zones), one with back-arc spreading and one without. For each case we examine the sensitivity of the inversion to the amount of surface velocity used: 1) full surface velocity data and 2) surface velocity data simplified using a single scalar average (2-D equivalent to an Euler pole) for each plate. We can recover plate boundary strength in each case, even in the presence of highly nonlinear flow with extreme variations in viscosity. Additionally, we ascribe an uncertainty in each plate's velocity and perform an uncertainty quantification (UQ) through the Hessian of the misfit in plate velocities. We find that as plate boundaries become strongly coupled, the uncertainty in the inferred plate boundary strength decreases. For very weak, uncoupled subduction zones, the uncertainty of inferred plate margin strength increases since there is little sensitivity between plate margin strength and plate velocity. This result is significant because it implies we can infer which plate boundaries are more coupled (seismically) for a realistic dynamic model of plates and mantle flow.

Linking the tectonic evolution with fluid history in magma-poor rifted margins: tracking mantle- and continental crust-related fluids

NASA Astrophysics Data System (ADS)

Pinto, V. H. G.; Manatschal, G.; Karpoff, A. M.

2014-12-01

The thinning of the crust and the exhumation of subcontinental mantle is accompanied by a series of extensional detachment faults. Exhumation of mantle and crustal rocks is intimately related to percolation of fluids along detachment faults leading to changes in mineralogy and chemistry of the mantle, crustal and sedimentary rocks. Field observation, analytical methods, refraction/reflection and well-core data, allowed us to investigate the role of fluids in the Iberian margin and former Alpine Tethys distal margins and the Pyrenees rifted system. In the continental crust, fluid-rock interaction leads to saussuritization that produces Si and Ca enriched fluids found in forms of veins along the fault zone. In the zone of exhumed mantle, large amounts of water are absorbed in the first 5-6 km of serpentinized mantle, which has the counter-effect of depleting the mantle of elements (e.g., Si, Ca, Mg, Fe, Mn, Ni and Cr) forming mantle-related fluids. Using Cr-Ni-V and Fe-Mn as tracers, we show that in the distal margin, mantle-related fluids used detachment faults as pathways and interacted with the overlying crust, the sedimentary basin and the seawater, while further inward parts of the margin, continental crust-related fluids enriched in Si and Ca impregnated the fault zone and may have affected the sedimentary basin. The overall observations and results enable us to show when, where and how these interactions occurred during the formation of the rifted margin. In a first stage, continental crust-related fluids dominated the rifted systems. During the second stage, mantle-related fluids affected the overlying syn-tectonic sediments through direct migration along detachment faults at the future distal margin. In a third stage, these fluids reached the seafloor, "polluted" the seawater and were absorbed by post-tectonic sediments. We conclude that a significant amount of serpentinization occurred underneath the thinned continental crust, that the mantle-related fluids might have modified the chemical composition of the sediments and seawater. We propose that the chemical signature of serpentinization that occurs during the mantle exhumation is recorded in the sediments and may serve as a proxy to date serpentinization and mantle exhumation in present day magma-poor rifted margins.

The Maliac Ocean: the origin of the Tethyan Hellenic ophiolites

NASA Astrophysics Data System (ADS)

Ferriere, Jacky; Baumgartner, Peter O.; Chanier, Frank

2016-10-01

The Hellenides, part of the Alpine orogeny in Greece, are rich in ophiolitic units. These ophiolites and associated units emplaced during Jurassic obduction, testify for the existence of one, or several, Tethyan oceanic realms. The paleogeography of these oceanic areas has not been precisely described. However, all the authors now agree on the presence of a main Triassic-Jurassic ocean on the eastern side of the Pelagonian zone (Vardar Domain). We consider that this Maliac Ocean is the most important ocean in Greece and Albania. Here, we limit the detailed description of the Maliac Ocean to the pre-convergence period of approximately 70 Ma between the Middle Triassic rifting to the Middle Jurassic convergence period. A quick overview on the destiny of the different parts of the Maliac Ocean during the convergence period is also proposed. The studied exposures allow to reconstruct: (1) the Middle to Late Triassic Maliac oceanic lithosphere, corresponding to the early spreading activity at a Mid-Oceanic Ridge; (2) the Western Maliac Margin, widely exposed in the Othris and Argolis areas; (3) the Eastern-Maliac Margin in the eastern Vardar domain (Peonias and Paikon zones). We established the following main characteristics of the Maliac Ocean: (1) the Middle Triassic rifting marked by a rapid subsidence and volcanism seems to be short-lived (few My); (2) the Maliac Lithosphere is only represented by Middle to Late Triassic units, especially the Fourka unit, composed of WPB-OIB and MORB pillow-lavas, locally covered by a pelagic Middle Triassic to Middle Jurassic sedimentary cover; (3) the Western Margin is the most complete and our data allow to distinguish a proximal and a deeper distal margin; (4) the evolution of the Eastern Margin (Peonias and Paikon series) is similar to that of the W-Margin, except for its Jurassic terrigenous sediments, while the proximal W-Margin was dominated by calcarenites; (5) we show that the W- and E-margins are not Volcanic Passive Margins; and (6) during the Middle Jurassic convergence period, the Eastern Margin became an active margin and both margins were affected by obduction processes.

Geochemical evidence of mantle reservoir evolution during progressive rifting along the western Afar margin

NASA Astrophysics Data System (ADS)

Rooney, Tyrone O.; Mohr, Paul; Dosso, Laure; Hall, Chris

2013-02-01

The Afar triple junction, where the Red Sea, Gulf of Aden and African Rift System extension zones converge, is a pivotal domain for the study of continental-to-oceanic rift evolution. The western margin of Afar forms the southernmost sector of the western margin of the Red Sea rift where that margin enters the Ethiopian flood basalt province. Tectonism and volcanism at the triple junction had commenced by ˜31 Ma with crustal fissuring, diking and voluminous eruption of the Ethiopian-Yemen flood basalt pile. The dikes which fed the Oligocene-Quaternary lava sequence covering the western Afar rift margin provide an opportunity to probe the geochemical reservoirs associated with the evolution of a still active continental margin. 40Ar/39Ar geochronology reveals that the western Afar margin dikes span the entire history of rift evolution from the initial Oligocene flood basalt event to the development of focused zones of intrusion in rift marginal basins. Major element, trace element and isotopic (Sr-Nd-Pb-Hf) data demonstrate temporal geochemical heterogeneities resulting from variable contributions from the Afar plume, depleted asthenospheric mantle, and African lithosphere. The various dikes erupted between 31 Ma and 22 Ma all share isotopic signatures attesting to a contribution from the Afar plume, indicating this initial period in the evolution of the Afar margin was one of magma-assisted weakening of the lithosphere. From 22 Ma to 12 Ma, however, diffuse diking during continued evolution of the rift margin facilitated ascent of magmas in which depleted mantle and lithospheric sources predominated, though contributions from the Afar plume persisted. After 10 Ma, magmatic intrusion migrated eastwards towards the Afar rift floor, with an increasing fraction of the magmas derived from depleted mantle with less of a lithospheric signature. The dikes of the western Afar margin reveal that magma generation processes during the evolution of this continental rift margin are increasingly dominated by shallow decompressional melting of the ambient asthenosphere, the composition of which may in part be controlled by preferential channeling of plume material along the developing neo-oceanic axes of extension.

Seismic investigation on the Littoral Faults Zone in the northern continental margin of South China Sea

NASA Astrophysics Data System (ADS)

Sun, J.; Xu, H.; Xia, S.; Cao, J.; Wan, K.

2017-12-01

The continental margin of the northern South China Sea (SCS) had experienced continuous evolution from an active continental margin in the late Mesozoic to a passive continental margin in the Cenozoic. The 1200km-long Littoral Faults Zone (LFZ) off the mainland South China was suggested to represent one of the sub-plate boundaries and play a key role during the evolution. Besides, four devastating earthquakes with magnitude over 7 and another 11 destructive events with M>6 were documented to have occurred along the LFZ. However, its approximity to the shoreline, the shallow water depth, and the heavy fishing activities make it hard to conduct a marine seismic investigation. As a result, understandings about the LFZ before 2000 were relatively poor and mostly descriptive. After two experiments of joint onshore-offshore wide-angle seismic surveys in the 1st decade of this century, several cruses aiming to unveil the deep structure of the LFZ were performed in the past few years, with five joint onshore-offshore wide-angle seismic survey profiles completed. Each of these profiles is perpendicular to the shoreline, with four to five seismometers of campaign mode deployed on the landside and over ten Ocean Bottom Seismometers (OBSs) spacing at 20km deployed on the seaside. Meanwhile, multi-channel seismic (MCS) data along these profiles were obtained simultaneously. Based on these data, velocity models from both forward modeling and inversion were obtained. According to these models, the LFZ was imaged to be a low-velocity fractured zone dipping to the SSE-SE at a high-angle and cutting through the thinned continental crust at some locations. Width of the fractured zone varies from 6km to more than 10km from site to site. With these results, it is suggested that the LFZ accommodates the stresses from both the east side, where the Eurasia/Philippine Sea plate converging and mountain building is ongoing, and the west side, where a strike-slip between the Indochina peninsular and the South China is occurring. Moreover, a low-velocity layer on the top of the lower-crust was also modeled, and its intersection with the fractured zone formed a weak zone where stresses concentrated, and led to those abovementioned earthquakes along the LFZ.

Regional distribution of volcaniclastic layer and its implication for segmentation of the Nankai seismogenic zone

NASA Astrophysics Data System (ADS)

Sasaki, T.; Lim, J.; Higashi, M.; Park, J.

2010-12-01

The Nankai Trough is known as one of the best-suited convergent plate margins for studying accretionary prism growth as well as subduction zone earthquakes. Along the Nankai accretionary margin off southwest Japan, the Shikoku Basin which formed 26-15 Ma as backarc spreading in the Philippine Sea Plate is being subducted about 4 cm/year to the northwest. The Deep Sea Drilling Project (DSDP) and Ocean Drilling Program (ODP) penetrated the Nankai accretionary prism and the incoming sedimentary section along the Ashizuri and Muroto transects, off Shikoku Island. Also, Integrated Ocean Drilling Program (IODP), which represented just one part of a multi-stage project known as the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) has been conducting drilling cruises now. IODP Expedition 322 in 2009, the coring was carried out at two drilling sites on the northern part of the Shikoku Basin in the subducting Philippine Sea plate. One of the major achievements of Expedition 322 is a discovery of late Miocene (10.2-7.6 Ma) tuffaceous and volcaniclastic sandstone layer (Underwood et al., IODP Prel. Rept. 322, 2009) that has not been previously recognized in the Nankai Trough. Based on age and volcanic sand content analysis, these volcaniclastic layers were unique to the Shikoku Basin off Kii Peninsula. The closest source of this volcanic layer was supposed to be the Izu-Bonin arc. Subducted sediments ultimately affect subduction zone geochemistry, thermal structure, and seismogenesis. High porosity of the volcaniclastic sandstone layer suggests the transportation of fluid to the subduction zone, it might affect the initiation and evolution of the decollement zone or plate boundary fault in the Nankai Trough. We interpreted single channel and multichannel seismic reflection profiles that have been acquired in the Nankai Trough margin by Japan Agency for Marine-Earth Science and Technology (JAMSTEC) since the year of 1997. We tried to map the major seismic layers such as volcaniclastic layer, volcanic ash layer and turbidite layers which were found at drilling sites in the IODP Expedition 322 in the northern Shikoku Basin. As a result, we recognized that these prominent seismic layers are widely distributed in the northern Shikoku Basin. In this talk, we will show specific seismic layers directly connecting to the decollement at the Nankai Trough axis, and discuss its implications for subduction processes in the Nankai Trough margin.

Mobilization of beryllium in the sedimentary column at convergent margins

USGS Publications Warehouse

You, C.-F.; Morris, J.D.; Gieskes, J.M.; Rosenbauer, R.; Zheng, S.H.; Xu, X.; Ku, T.-L.; Bischoff, J.L.

1994-01-01

Studies of Be distributions in subduction zone sediments will help to understand questions regarding the enrichments of cosmogenic Be-10 in arc volcanic rocks. Analyses of Be-10 and Be-9 in sediments of Ocean Drilling Program Site 808, Nankai Trough and Be-9 in porewaters of Site 808 and Sites 671 and 672, Barbados ridge complex, show significant decreases in solid phase Be-10 and large increases of porewater Be-9 at the location of the de??collement zone and below or at potential flow conduits. These data imply the potential mobilization of Be during pore fluid expulsion upon sediment burial. Experiments involving reaction between a de??collement sediment and a synthetic NaCl-CaCl2 solution at elevated pressure and temperatures were conducted in an attempt to mimic early subduction zone processes. The results demonstrate that Be is mobilized under elevated pressure and temperature with a strong pH dependence. The Be mobilization provides an explanation of Be-10 enrichment in arc volcanic rocks and supports the argument of the importance of the fluid processes in subduction zones at convergent margins. ?? 1994.

Wave Attenuation and Gas Exchange Velocity in Marginal Sea Ice Zone

NASA Astrophysics Data System (ADS)

Bigdeli, A.; Hara, T.; Loose, B.; Nguyen, A. T.

2018-03-01

The gas transfer velocity in marginal sea ice zones exerts a strong control on the input of anthropogenic gases into the ocean interior. In this study, a sea state-dependent gas exchange parametric model is developed based on the turbulent kinetic energy dissipation rate. The model is tuned to match the conventional gas exchange parametrization in fetch-unlimited, fully developed seas. Next, fetch limitation is introduced in the model and results are compared to fetch limited experiments in lakes, showing that the model captures the effects of finite fetch on gas exchange with good fidelity. Having validated the results in fetch limited waters such as lakes, the model is next applied in sea ice zones using an empirical relation between the sea ice cover and the effective fetch, while accounting for the sea ice motion effect that is unique to sea ice zones. The model results compare favorably with the available field measurements. Applying this parametric model to a regional Arctic numerical model, it is shown that, under the present conditions, gas flux into the Arctic Ocean may be overestimated by 10% if a conventional parameterization is used.

Dissolution of bedded rock salt: A seismic profile across the active eastern margin of the Hutchinson Salt Member, central Kansas

USGS Publications Warehouse

Anderson, N.L.; Hopkins, J.; Martinez, A.; Knapp, R.W.; Macfarlane, P.A.; Watney, W.L.; Black, R.

1994-01-01

Since late Tertiary, bedded rock salt of the Permian Hutchinson Salt Member has been dissolved more-or-less continuously along its active eastern margin in central Kansas as a result of sustained contact with unconfined, undersaturated groundwater. The associated westward migration of the eastern margin has resulted in surface subsidence and the contemporaneous sedimentation of predominantly valley-filling Quarternary alluvium. In places, these alluvium deposits extend more than 25 km to the east of the present-day edge of the main body of contiguous rock salt. The margin could have receded this distance during the past several million years. From an environmental perspective, the continued leaching of the Hutchinson Salt is a major concern. This predominantly natural dissolution occurs in a broad zone across the central part of the State and adversely affects groundwater and surface-water quality as nonpoint source pollution. Significant surface subsidence occurs as well. Most of these subsidence features have formed gradually; others developed in a more catastrophic manner. The latter in particular pose real threats to roadways, railways, and buried oil and gas pipelines. In an effort to further clarify the process of natural salt dissolution in central Kansas and with the long-term goal of mitigating the adverse environmental affects of such leaching, the Kansas Geological Survey acquired a 4-km seismic profile across the eastern margin of the Hutchinson Salt in the Punkin Center area of central Kansas. The interpretation of these seismic data (and supporting surficial and borehole geologic control) is consistent with several hypotheses regarding the process and mechanisms of dissolution. More specifically these data support the theses that: 1. (1) Dissolution along the active eastern margin of the Hutchinson Salt Member was initiated during late Tertiary. Leaching has resulted in the steady westward migration of the eastern margin, surface subsidence, and the contemporaneous deposition of predominantly valley-filling Quarternary alluvium. 2. (2) Along the active eastern margin, the rock salt has been leached vertically from the top down, and horizontally along the uppermost remnant bedded soluble layer(s). As a result, the eastern margin thickens gradually (up to 90 m) and in a stepwise manner from east to west for distances on the order 5-15 km. 3. (3) In places, the Hutchinson Salt Member has been leached locally along NNE-trending paleoshear zones situated to the west of the present-day edge of the main body of contiguous rock salt. Leaching at these sites initiated when the main dissolution front impinged upon preexisting shear zones. ?? 1994.

Along-Strike Variation in Geometry and Kinematics of a Major, Active Intracontinental Thrust System: the Pred-Terskey Fault Zone, Kyrgyz Tien Shan, Central Asia

NASA Astrophysics Data System (ADS)

Burgette, R. J.; Weldon, R. J.; Abdrakhmatov, K. Y.; Ormukov, C.

2004-12-01

The Pred-Terskey fault zone defines the southern margin of the Issyk-Kul basin, extending eastward over 250 km from at least the Chu River to the Kazakhstan border, and appears to be one of the most active zones in the Kyrgyz Tien Shan. Despite a diversity of structural styles and changes of vergence at the surface, the lateral continuity and overall geometry of the zone is consistent with a single north vergent thrust at depth, which uplifts the Terskey Range and generally tilts the south margin of the basin to the north. This northward tilting of the margin is probably due to a flattening of the fault as it approaches the surface. In spite of historical quiescence, it is likely capable of producing great earthquakes. We have conducted detailed field mapping coupled with terrace profiling and dating at seven representative, well-exposed areas of the fault zone. Based on these field observations and satellite image and air photo interpretation along the entire zone, we identify three major divisions in structural style expressed at the surface. The western segment is typified by the Tura-Su, Ak-Terek and Ton areas. A series of left-stepping, south-vergent, basement-involved reverse faults and folds are uplifting the southern margin of the Issyk-Kul basin in this area. The resulting uphill-facing scarps have trapped and diverted many of the rivers flowing north from the Terskey Range. Tertiary strata and Quaternary geomorphic surfaces show consistent, progressive northward tilting across the entire zone. The west-central segment is represented by the Kajy-Say area. South-vergent reverse faults and a north-vergent backthrust have uplifted an arcuate granite block. Offshore of this area, the lake floor descends to a sharp break in slope with a low relief area at a depth of about 650 m. Late Quaternary geomorphic features do not show evidence of tilting. In contrast to the areas east and west, the major north-dipping thrust is likely planar over this segment and daylights at the lake floor break in slope. The east-central segment is exemplified by the Barskaun and Jety Oguz areas. A high angle reverse fault juxtaposes Paleozoic rock against Tertiary sediments. To the north, a thrust fault with a sinuous trace places north-dipping Tertiary rock over the nearly horizontal basin floor. Quaternary terraces in the hanging wall of this fault record progressive northward tilting. North of the thrust fault a series of anticlines are growing out of the basin sediments. The eastern segment, which includes the Jergalan River valley, lacks a low angle thrust fault at the basin margin. Along this segment, the basement reverse fault uplifts Paleozoic rock against Quaternary basin sediment. To the north of this range-bounding structure, late Quaternary terraces are offset by south-vergent scarps. We are calculating geologic slip rates for each of the seven sites along the Pred-Terskey zone by dating terraces and constructing structural models consistent with both the rock and terrace records. Based on preliminary radiocarbon dates, a prominent Jety Oguz River terrace is 50 +/- 10 ka. The terrace is tilted 0.5° relative to the modern river, and with the low angle fault branching off of the basement reverse fault at dips ranging between 45° and 90° , the slip rate of this fault is 6 +/- 4 mm/yr. This is consistent with the GPS shortening rate across the Pred-Terskey zone at this longitude.

Variability of High Resolution Vp/Vs and Seismic Velocity Structure Along the Nicaragua/Costa Rica Segment of the Middle America Subduction Zone

NASA Astrophysics Data System (ADS)

Moore-Driskell, M. M.; DeShon, H. R.

2012-12-01

Previous studies of subduction zone earthquakes have shown that fault conditions control earthquake rupture and behavior. There are many potential properties that may vary along the subduction margin that could cause fault zone variability, including plate age, temperature, and/or geometry, convergence rate, state of hydration, overriding geology, subducting sediment packages, or subducting seamounts/ridges. The Nicaragua/Costa Rica segment of the Middle America subduction zone is highly variable along strike and down dip. We use this margin to examine how these variable conditions affect earthquake behavior by determining local ratios of compressional to shear wave velocities (Vp/Vs) and detailed seismic velocity structure. Vp/Vs is one of the best tools available to reliably define fault conditions because it is directly related to the Poisson's ratio of the fault material, and it is sensitive to the presence of fluids and changing permeability. Thus with well-resolved near source Vp/Vs measurements we can infer composition and/or high fluid pressures. Here, we use a technique developed by Lin and Shearer (2007) to determine local Vp/Vs in small areas (~2 x 2 x 2 km) with high seismicity. Within the seismogenic zone, we find the margin to be highly variable along strike in Vp/Vs and seismic velocity. These changes correlate to documented variability in incoming plate properties. Increased Vp/Vs is associated with intraplate earthquakes along Nicaragua and northern Costa Rica. We compare our results with other geophysical studies including new high-resolution images of seismic velocity structure, an extensive catalog of high quality relocated events, apparent stress calculations, coupling, and SSE/NVT occurrence. A better understanding of the connection between fault properties and earthquake behavior gives insight into the role of fluids in seismogenesis, the spectrum of earthquake rupture, and possible hazard at subduction zones.

The evolution of a Gondwanan collisional orogen: A structural and geochronological appraisal from the Southern Granulite Terrane, South India

NASA Astrophysics Data System (ADS)

Plavsa, Diana; Collins, Alan S.; Foden, John D.; Clark, Chris

2015-05-01

Gondwana amalgamated along a suite of Himalayan-scale collisional orogens, the roots of which lace the continents of Africa, South America, and Antarctica. The Southern Granulite Terrane of India is a generally well-exposed, exhumed, Gondwana-forming orogen that preserves a record of the tectonic evolution of the eastern margin of the East African Orogen during the Ediacaran-Cambrian (circa 600-500 Ma) as central Gondwana formed. The deformation associated with the closure of the Mozambique Ocean and collision of the Indian and East African/Madagascan cratonic domains is believed to have taken place along the southern margin of the Salem Block (the Palghat-Cauvery Shear System, PCSS) in the Southern Granulite Terrane. Investigation of the structural fabrics and the geochronology of the high-grade shear zones within the PCSS system shows that the Moyar-Salem-Attur shear zone to the north of the PCSS system is early Paleoproterozoic in age and associated with dextral strike-slip motion, while the Cauvery shear zone (CSZ) to the south of the PCSS system can be loosely constrained to circa 740-550 Ma and is associated with dip-slip dextral transpression and north side-up motion. To the south of the proposed suture zone (the Cauvery shear zone), the structural fabrics of the Northern Madurai Block suggest four deformational events (D1-D4), some of which are likely to be contemporaneous. The timing of high pressure-ultrahigh temperature metamorphism and deformation (D1-D3) in the Madurai Block (here interpreted as the southern extension of Azania) is constrained to circa 550-500 Ma and interpreted as representing collisional orogeny and subsequent orogenic collapse of the eastern margin of the East African Orogen. The disparity in the nature of the structural fabrics and the timing of the deformation in the Salem and the Madurai Blocks suggest that the two experienced distinct tectonothermal events prior to their amalgamation along the Cauvery shear zone during the Ediacaran/Cambrian.

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin

NASA Astrophysics Data System (ADS)

van Hengstum, Peter J.; Donnelly, Jeffrey P.; Fall, Patricia L.; Toomey, Michael R.; Albury, Nancy A.; Kakuk, Brian

2016-02-01

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.

Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells

PubMed Central

Backer, Ronald; Schwandt, Timo; Greuter, Mascha; Oosting, Marije; Jüngerkes, Frank; Tüting, Thomas; Boon, Louis; O’Toole, Tom; Kraal, Georg; Limmer, Andreas; den Haan, Joke M. M.

2009-01-01

The spleen is the lymphoid organ that induces immune responses toward blood-borne pathogens. Specialized macrophages in the splenic marginal zone are strategically positioned to phagocytose pathogens and cell debris, but are not known to play a role in the activation of T-cell responses. Here we demonstrate that splenic marginal metallophilic macrophages (MMM) are essential for cross-presentation of blood-borne antigens by splenic dendritic cells (DCs). Our data demonstrate that antigens targeted to MMM as well as blood-borne adenoviruses are efficiently captured by MMM and exclusively transferred to splenic CD8+ DCs for cross-presentation and for the activation of cytotoxic T lymphocytes. Depletion of macrophages in the marginal zone prevents cytotoxic T-lymphocyte activation by CD8+ DCs after antibody targeting or adenovirus infection. Moreover, we show that tumor antigen targeting to MMM is very effective as antitumor immunotherapy. Our studies point to an important role for splenic MMM in the initial steps of CD8+ T-cell immunity by capturing and concentrating blood-borne antigens and the transfer to cross-presenting DCs which can be used to design vaccination strategies to induce antitumor cytotoxic T-cell immunity. PMID:20018690

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin

PubMed Central

van Hengstum, Peter J.; Donnelly, Jeffrey P.; Fall, Patricia L.; Toomey, Michael R.; Albury, Nancy A.; Kakuk, Brian

2016-01-01

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval. PMID:26906670

Transport of contaminants by Arctic sea ice and surface ocean currents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfirman, S.

1995-12-31

Sea ice and ocean currents transport contaminants in the Arctic from source areas on the shelves, to biologically active regions often more than a thousand kilometers away. Coastal regions along the Siberian margin are polluted by discharges of agricultural, industrial and military wastes in river runoff, from atmospheric deposition and ocean dumping. The Kara Sea is of particular concern because of deliberate dumping of radioactive waste, as well as the large input of polluted river water. Contaminants are incorporated in ice during suspension freezing on the shelves, and by atmospheric deposition during drift. Ice releases its contaminant load through brinemore » drainage, surface runoff of snow and meltwater, and when the floe disintegrates. The marginal ice zone, a region of intense biological activity, may also be the site of major contaminant release. Potentially contaminated ice from the Kara Sea is likely to influence the marginal ice zones of the Barents and Greenland seas. From studies conducted to date it appears that sea ice from the Kara Sea does not typically enter the Beaufort Gyre, and thus is unlikely to affect the northern Canadian and Alaskan margins.« less

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin

USGS Publications Warehouse

van Hengstrum, Peter J.; Donnelly, Jeffrey P.; Fall, Patricia L.; Toomey, Michael; Albury, Nancy A.; Kakuk, Brian

2016-01-01

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin.

PubMed

van Hengstum, Peter J; Donnelly, Jeffrey P; Fall, Patricia L; Toomey, Michael R; Albury, Nancy A; Kakuk, Brian

2016-02-24

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.

A low-angle detachment fault revealed: Three-dimensional images of the S-reflector fault zone along the Galicia passive margin

NASA Astrophysics Data System (ADS)

Schuba, C. Nur; Gray, Gary G.; Morgan, Julia K.; Sawyer, Dale S.; Shillington, Donna J.; Reston, Tim J.; Bull, Jonathan M.; Jordan, Brian E.

2018-06-01

A new 3-D seismic reflection volume over the Galicia margin continent-ocean transition zone provides an unprecedented view of the prominent S-reflector detachment fault that underlies the outer part of the margin. This volume images the fault's structure from breakaway to termination. The filtered time-structure map of the S-reflector shows coherent corrugations parallel to the expected paleo-extension directions with an average azimuth of 107°. These corrugations maintain their orientations, wavelengths and amplitudes where overlying faults sole into the S-reflector, suggesting that the parts of the detachment fault containing multiple crustal blocks may have slipped as discrete units during its late stages. Another interface above the S-reflector, here named S‧, is identified and interpreted as the upper boundary of the fault zone associated with the detachment fault. This layer, named the S-interval, thickens by tens of meters from SE to NW in the direction of transport. Localized thick accumulations also occur near overlying fault intersections, suggesting either non-uniform fault rock production, or redistribution of fault rock during slip. These observations have important implications for understanding how detachment faults form and evolve over time. 3-D seismic reflection imaging has enabled unique insights into fault slip history, fault rock production and redistribution.

Wave effects on ocean-ice interaction in the marginal ice zone

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Hakkinen, Sirpa; Peng, Chih Y.

1993-01-01

The effects of wave train on ice-ocean interaction in the marginal ice zone are studied through numerical modeling. A coupled two-dimensional ice-ocean model has been developed to include wave effects and wind stress for the predictions of ice edge dynamics. The sea ice model is coupled to the reduced-gravity ocean model through interfacial stresses. The main dynamic balance in the ice momentum is between water-ice stress, wind stress, and wave radiation stresses. By considering the exchange of momentum between waves and ice pack through radiation stress for decaying waves, a parametric study of the effects of wave stress and wind stress on ice edge dynamics has been performed. The numerical results show significant effects from wave action. The ice edge is sharper, and ice edge meanders form in the marginal ice zone owing to forcing by wave action and refraction of swell system after a couple of days. Upwelling at the ice edge and eddy formation can be enhanced by the nonlinear effects of wave action; wave action sharpens the ice edge and can produce ice meandering, which enhances local Ekman pumping and pycnocline anomalies. The resulting ice concentration, pycnocline changes, and flow velocity field are shown to be consistent with previous observations.

Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML

ClinicalTrials.gov

2017-07-11

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia; Philadelphia Positive Adult Acute Lymphoblastic Leukemia; Philadelphia Positive Childhood Acute Lymphoblastic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Relapsing Chronic Myelogenous Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

Absolute Stability Analysis of a Phase Plane Controlled Spacecraft

NASA Technical Reports Server (NTRS)

Jang, Jiann-Woei; Plummer, Michael; Bedrossian, Nazareth; Hall, Charles; Jackson, Mark; Spanos, Pol

2010-01-01

Many aerospace attitude control systems utilize phase plane control schemes that include nonlinear elements such as dead zone and ideal relay. To evaluate phase plane control robustness, stability margin prediction methods must be developed. Absolute stability is extended to predict stability margins and to define an abort condition. A constrained optimization approach is also used to design flex filters for roll control. The design goal is to optimize vehicle tracking performance while maintaining adequate stability margins. Absolute stability is shown to provide satisfactory stability constraints for the optimization.

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

ClinicalTrials.gov

2017-04-25

Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Juvenile Myelomonocytic Leukemia; Mast Cell Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Myelodysplastic Syndromes; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer

ClinicalTrials.gov

2017-08-09

Acute Undifferentiated Leukemia; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Myelomonocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Juvenile Myelomonocytic Leukemia; Mast Cell Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Myeloid/NK-cell Acute Leukemia; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Systemic Amyloidosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Renal Cell Cancer; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage II Multiple Myeloma; Stage III Multiple Myeloma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Adenocarcinoma in situ of the uterine cervix--a systematic review.

PubMed

Baalbergen, Astrid; Helmerhorst, Theo J M

2014-11-01

This study aimed to review literature if therapeutic strategies in adenocarcinoma in situ of the cervix could lead to a more conservative approach. A review of the literature was conducted using a Medline search for articles published between 1966 and 2013. Thirty-five studies showed that after a radical cone, 16.5% residual disease in the re-cone or uterus was found. After cone with positive margins, residual abnormalities were found in 49.3%. Thirty-seven studies showed 5% recurrence rate after conservative therapy (large loop excision transformation zone-cold knife conization. After conization with negative margins, the risk of recurrence was 3%. Adenocarcinoma in situ is a relatively rare premalignant but increasingly frequent lesion of the cervix. Although there is a risk of relapse (3%) with a chance of malignancy (<1%), this risk is so small that conservative treatment with negative margins by large loop excision transformation zone or cold knife conization is justified and justifiable not only for women to have children.

Large loop excision of the transformation zone for treating cervical intraepithelial neoplasia: a 12-year experience.

PubMed

Paraskevaidis, E; Koliopoulos, G; Malamou-Mitsi, V; Zikopoulos, K; Paschopoulos, M; Pappa, L; Agnantis, N J; Loli, D E

2001-01-01

Although the existing evidence suggests that there is no obviously superior conservative method for treating cervical intraepithelial neoplasia (CIN), one of the most widely used is the large loop excision of the transformation zone (LLETZ). A total of 897 women who were treated with LLETZ at our colposcopy clinic from 1989 to 2000 were retrospectively studied. Forty women did not have significant cervical pathology (4.5% over-treatment rate). Clear margins of excision were obtained in 748 (88.5%) of the 845 cases of CIN or microinvasive cancers. Treatment failure rates were 4.7% for clear margins and 26.8% for involved or uncertain. LLETZ is a fast and reliable method of treating CIN and microinvasive carcinoma. Generalized cauterization of the resulting crater should be avoided and satellite HPV lesions ablated. Involved margins have a higher treatmentfailure rate, therefore a larger excision is recommended as cervical craters regenerate. Treatment in pregnant women can be delayed until postpartum provided they have adequate surveillance during pregnancy.

Petrography and geochemistry of clastic rocks within the Inthanon zone, northern Thailand: Implications for Paleo-Tethys subduction and convergence

NASA Astrophysics Data System (ADS)

Hara, Hidetoshi; Kunii, Miyuki; Hisada, Ken-ichiro; Ueno, Katsumi; Kamata, Yoshihito; Srichan, Weerapan; Charusiri, Punya; Charoentitirat, Thasinee; Watarai, Megumi; Adachi, Yoshiko; Kurihara, Toshiyuki

2012-11-01

The provenance, source rock compositions, and sediment supply system for a convergence zone of the Paleo-Tethys were reconstructed based on the petrography and geochemistry of clastic rocks of the Inthanon Zone, northern Thailand. The clastic rocks are classified into two types based on field and microscopic observations, the modal composition of sandstone, and mineral compositions: (1) lithic sandstone and shale within mélange in a Permo-Triassic accretionary complex; and (2) Carboniferous quartzose sandstone and mudstone within the Sibumasu Block. Geochemical data indicate that the clastic rocks of the mélange were derived from continental island arc and continental margin settings, which correspond to felsic volcanic rocks within the Sukhothai Zone and quartz-rich fragments within the Indochina Block, respectively. The results of a mixing model indicate the source rocks were approximately 35% volcanic rocks of the Sukhothai Zone and 65% craton sandstone and upper continental crust of the Indochina Block. In contrast, Carboniferous quartzose sedimentary rocks within the Sibumasu Block originated from a continental margin, without a contribution from volcanic rocks. In terms of Paleo-Tethys subduction, a continental island arc in the Sukhothai Zone evolved in tandem with Late Permian-Triassic forearc basins and volcanic activity during the Middle-early Late Triassic. The accretionary complex formed contemporaneously with the evolution of continental island arc during the Permo-Triassic, supplied with sediment from the Sukhothai Zone and the Indochina Block.

Magmatism evolution on the last Neoproterozoic development stage of the western Siberian active continental margin

NASA Astrophysics Data System (ADS)

Vernikovskaya, Antonina E.; Vernikovsky, Valery A.; Matushkin, Nikolay Yu.; Kadilnikov, Pavel I.; Romanova, Irina V.

2017-04-01

Rocks from active continental margin complexes are characterized by a wide variety of chemical compositions from depleted in alkali to alkali differentiates. When addressing issues of geodynamic settings in which such rocks form, it is important to understand the evolution of the host tectonic structure, as well as the chemical affiliation of the various rocks composing it. The Yenisey Ridge orogen located in the south-western framing of Siberia is one of the more studied regions with a long history of Neoproterozoic magmatic events. This orogen was formed during the collision of the Central Angara terrane with Siberia, which took place 761-718 Ma. Subsequent subduction-related events in the orogen have been recorded in the coeval magmatism (711-629 Ma) of two complexes: one is the active continental margin complex (Nb enriched igneous rocks - gabbroids, trachybasalts, A-type granites and carbonatites, including contact metasomatites zones with Nb mineralization), and the other one is an island arc complex (differentiated series volcanics, gabbroids and plagiogranites). The rocks of these complexes are respectively located in two suture zones: the Tatarka-Ishimba zone that formed due to the collision mentioned above, and the Yenisei suture marking the subduction zone [Vernikovsky et al., 2003; 2008]. The final Neoproterozoic stage in the evolution of the active margin of Siberia is manifested as adakite-gabbro-anorthosite magmatism in the 576-546 Ma interval. Our results indicate a genetic relationship between the adakites and their host NEB-type metabasites of the Zimovey massif. These Neoproterozoic adakites could have formed in a setting of transform-strike-slip drift of lithospheric plates after the subduction stopped, both from a crustal and mantle-crustal source, similarly to the Cenozoic magmatic complexes of the transform margin in the eastern framing of Eurasia [Khanchuk et al., 2016]. Vernikovsky V.A., Vernikovskaya A.E., Kotov A.B., Sal'nikova E.B., Kovach V.P. Neoproterozoic accretionary and collisional events on the western margin of the Siberian craton: new geological and geochronological evidence from the Yenisey Ridge // Tectonophysics, 2003, V. 375, P. 147-168. Vernikovsky V.A., Vernikovskaya A.E., Sal'nikova E.B., Berezhnaya N.G., Larionov A.N., Kotov A.B., Kovach V.P., Vernikovskaya I.V., Matushkin N.Yu., Yasenev A.M. Late Riphean alkaline magmatism in the western margin of the Siberian Craton: A result of continental rifting or accretionary events? // Doklady Earth Sciences, 2008, V. 419, Iss. 1, P. 226-230. Khanchuk A.I., Kemkin I.V., Kruk N.N. The Sikhote-Alin orogenic belt, Russian South East: Terranes and the formation of continental lithosphere based on geological and isotopic Data // Journal of Asian Earth Sciences, 2016, V. 120, P. 117-138.

European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013

PubMed Central

Deininger, Michael W.; Rosti, Gianantonio; Hochhaus, Andreas; Soverini, Simona; Apperley, Jane F.; Cervantes, Francisco; Clark, Richard E.; Cortes, Jorge E.; Guilhot, François; Hjorth-Hansen, Henrik; Hughes, Timothy P.; Kantarjian, Hagop M.; Kim, Dong-Wook; Larson, Richard A.; Lipton, Jeffrey H.; Mahon, François-Xavier; Martinelli, Giovanni; Mayer, Jiri; Müller, Martin C.; Niederwieser, Dietger; Pane, Fabrizio; Radich, Jerald P.; Rousselot, Philippe; Saglio, Giuseppe; Saußele, Susanne; Schiffer, Charles; Silver, Richard; Simonsson, Bengt; Steegmann, Juan-Luis; Goldman, John M.; Hehlmann, Rüdiger

2013-01-01

Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of concepts and management. A European LeukemiaNet expert panel reviewed prior and new studies to update recommendations made in 2009. We recommend as initial treatment imatinib, nilotinib, or dasatinib. Response is assessed with standardized real quantitative polymerase chain reaction and/or cytogenetics at 3, 6, and 12 months. BCR-ABL1 transcript levels ≤10% at 3 months, <1% at 6 months, and ≤0.1% from 12 months onward define optimal response, whereas >10% at 6 months and >1% from 12 months onward define failure, mandating a change in treatment. Similarly, partial cytogenetic response (PCyR) at 3 months and complete cytogenetic response (CCyR) from 6 months onward define optimal response, whereas no CyR (Philadelphia chromosome–positive [Ph+] >95%) at 3 months, less than PCyR at 6 months, and less than CCyR from 12 months onward define failure. Between optimal and failure, there is an intermediate warning zone requiring more frequent monitoring. Similar definitions are provided for response to second-line therapy. Specific recommendations are made for patients in the accelerated and blastic phases, and for allogeneic stem cell transplantation. Optimal responders should continue therapy indefinitely, with careful surveillance, or they can be enrolled in controlled studies of treatment discontinuation once a deeper molecular response is achieved. PMID:23803709

Near N-S paleo-extension in the western Deccan region, India: Does it link strike-slip tectonics with India-Seychelles rifting?

NASA Astrophysics Data System (ADS)

Misra, Achyuta Ayan; Bhattacharya, Gourab; Mukherjee, Soumyajit; Bose, Narayan

2014-09-01

This is the first detailed report and analyses of deformation from the W part of the Deccan large igneous province (DLIP), Maharashtra, India. This deformation, related to the India-Seychelles rifting during Late Cretaceous-Early Paleocene, was studied, and the paleostress tensors were deduced. Near N-S trending shear zones, lineaments, and faults were already reported without significant detail. An E-W extension was envisaged by the previous workers to explain the India-Seychelles rift at ~64 Ma. The direction of extension, however, does not match with their N-S brittle shear zones and also those faults (sub-vertical, ~NE-SW/~NW-SE, and few ~N-S) we report and emphasize in this work. Slickenside-bearing fault planes, brittle shear zones, and extension fractures in meso-scale enabled us to estimate the paleostress tensors (directions and relative magnitudes). The field study was complemented by remote sensing lineament analyses to map dykes and shear zones. Dykes emplaced along pre-existing ~N-S to ~NE-SW/~NW-SE shears/fractures. This information was used to derive regional paleostress trends. A ~NW-SE/NE-SW minimum compressive stress in the oldest Kalsubai Subgroup and a ~N-S direction for the younger Lonavala, Wai, and Salsette Subgroups were deciphered. Thus, a ~NW/NE to ~N-S extension is put forward that refutes the popular view of E-W India-Seychelles extension. Paleostress analyses indicate that this is an oblique rifted margin. Field criteria suggest only ~NE-SW and ~NW-SE, with some ~N-S strike-slip faults/brittle shear zones. We refer this deformation zone as the "Western Deccan Strike-slip Zone" (WDSZ). The observed deformation was matched with offshore tectonics deciphered mainly from faults interpreted on seismic profiles and from magnetic seafloor spreading anomalies. These geophysical findings too indicate oblique rifting in this part of the W Indian passive margin. We argue that the Seychelles microcontinent separated from India only after much of the DLIP erupted. Further studies of magma-rich passive margins with respect to timing and architecture of deformation and emplacement of volcanics are required.

Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies

ClinicalTrials.gov

2017-12-22

Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; Adult Langerhans Cell Histiocytosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Mast Cell Leukemia; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Myeloid/NK-cell Acute Leukemia; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Anemia; Refractory Multiple Myeloma; Secondary Acute Myeloid Leukemia; Secondary Myelofibrosis; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Multiple Myeloma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia; Waldenstrom Macroglobulinemia

Pb-Sr-Nd-O isotopic characterization of Mesozoic rocks throughout the northern end of the Peninsular Ranges batholith: Isotopic evidence for the magmatic evolution of oceanic arc–continental margin accretion during the Late Cretaceous of southern California

USGS Publications Warehouse

Kistler, Ronald W.; Wooden, Joseph L.; Premo, Wayne R.; Morton, Douglas M.

2014-01-01

Within the duration of the U.S. Geological Survey (USGS)–based Southern California Areal Mapping Project (SCAMP), many samples from the northern Peninsular Ranges batholith were studied for their whole-rock radioisotopic systematics (rubidium-strontium [Rb-Sr], uranium-thorium-lead [U-Th-Pb], and samarium-neodymium [Sm-Nd]), as well as oxygen (O), a stable isotope. The results of three main studies are presented separately, but here we combine them (>400 analyses) to produce a very complete Pb-Sr-Nd-O isotopic profile of an arc-continent collisional zone—perhaps the most complete in the world. In addition, because many of these samples have U-Pb zircon as well as argon mineral age determinations, we have good control of the timing for Pb-Sr-Nd-O isotopic variations.The ages and isotopic variations help to delineate at least four zones across the batholith from west to east—an older western zone (126–108 Ma), a transitional zone (111–93 Ma), an eastern zone (94–91 Ma), and a much younger allochthonous thrust sheet (ca. 84 Ma), which is the upper plate of the Eastern Peninsular Ranges mylonite zone. Average initial 87Sr/86 Sr (Sri), initial 206Pb/204Pb (206 Pbi), initial 208Pb/204Pb (average 208Pbi), initial epsilon Nd (average εNdi), and δ18O signatures range from 0.704, 18.787, 38.445, +3.1, and 4.0‰–9.0‰, respectively, in the westernmost zone, to 0.7071, 19.199, 38.777, −5, and 9‰–12‰, respectively, in the easternmost zone. The older western zone is therefore the more chemically and isotopically juvenile, characterized mostly by values that are slightly displaced from a mantle array at ca. 115 Ma, and similar to some modern island-arc signatures. In contrast, the isotopic signatures in the eastern zones indicate significant amounts of crustal involvement in the magmatic plumbing of those plutons. These isotopic signatures confirm previously published results that interpreted the Peninsular Ranges batholith as a progressively contaminated magmatic arc. The Peninsular Ranges batholith magmatic arc was initially an oceanic arc built on Panthalassan lithosphere that eventually evolved into a continental margin magmatic arc collision zone, eventually overriding North American cratonic lithosphere. Our Pb-Sr-Nd data further suggest that the western arc rocks represent a nearshore or inboard oceanic arc, as they exhibit isotopic signatures that are more enriched than typical mid-ocean-ridge basalt (MORB). Isotopic signatures from the central zone are transitional and indicate that enriched crustal magma sources were becoming involved in the northern Peninsular Ranges batholith magmatic plumbing. As the oceanic arc–continental margin collision progressed, a mixture of oceanic mantle and continental magmatic sources transpired. Magmatic production in the northern Peninsular Ranges batholith moved eastward and continued to tap enriched crustal magmatic sources. Similar modeling has been previously proposed for two other western margin magmatic arcs, the Sierra Nevada batholith of central California and the Idaho batholith.Calculated initial Nd signatures at ca. 100 Ma for Permian–Jurassic and Proterozoic basement rocks from the nearby San Gabriel Mountains and possible source areas along the southwestern Laurentian margin of southern California, southwestern Arizona, and northern Sonora strongly suggest their involvement with deep crustal magma mixing beneath the eastern zones of the Peninsular Ranges batholith, as well as farther east in continental lithospheric zones.Last, several samples from the allochthonous, easternmost upper-plate zone, which are considerably younger (ca. 84 Ma) than any of the rocks from the northern Peninsular Ranges batholith proper, have even more enriched average Sri, 206Pbi, 208Pbi, and εNdisignatures of 0.7079, 19.344, 38.881, and −6.6, respectively, indicative of the most-evolved magma sources in the northern Peninsular Ranges batholith and similar to radioisotopic values for rocks from the nearby Transverse Ranges, suggesting a genetic connection between the two.

Structural style and tectonic evolution of the easternmost Gulf of Aden conjugate margins (Socotra - Southern Oman)

NASA Astrophysics Data System (ADS)

Nonn, Chloe; Leroy, Sylvie; Castilla, Raymi; de Clarens, Philippe; Lescanne, Marc

2016-04-01

Observations from distal rifted margins in present day magma-poor rifted margins led to the discovery of hyperextended crust and exhumed sub-continental mantle. This finding allowed to better figure out how thinning process are accommodate by tectonic structures, forming various crustal domains, as the deformation localized towards the future area of breakup. However, some of the current challenges are about clarifying how factors as oblique kinematic, pre-existing structures and volcanism can control the 3D geometry and crustal architecture of the passive margins? A key to better understand the rifting evolution in its entirety is to study conjugate margins. The gulf of Aden is a young oceanic basin (with a global trend about N75°E) oblique to the divergence (about 30°N), separating Arabia from Somalia of less than 800 km. Thanks to its immerged margins and its thin post-rift sediment cover, the gulf of Aden basin is a natural laboratory to investigate conjugate margins and strain localisation throughout the rift history. In this contribution, we focus our interest on offshore Socotra Island (Yemen) and its conjugate in Southeastern Oman. This area extends from Socotra-Hadbeen (SHFZ) and the eastern Gulf of Aden fault zones (EGAFZ). In the easternmost part of the gulf of Aden, we provide new insights into crustal deformation and emplacement of the new oceanic crust thanks to bathymetric, magnetic, gravimetric data and single-, multi-channel, high speed seismic reflection data collected during Encens-Sheba (2000), Encens (2006) and the more recent Marges-Aden (2012) cruises respectively. The results obtained after compilation of these data, previous geological (field works) and geophysical (receiver functions, Pn-tomography, magnetic anomalies, heat flow) studies on the focused area, allowed us to provide new structural mapping and stratigraphic correlation between onshore and offshore parts of Socotra and Oman margins. We precisely defined and map crustal domains, syn-tectonic structures and oblique accommodation zones to highlighted asymmetrical margins, characterized by strong lateral variability of crustal domains along and across strike. From external to internal domains of the margins and in between SHFZ and EGAFZ (first-order segment), this study details sharp necking domain and complex transition from hyperextended to oceanic crust characterized by: (i) hyperextended crust affected by volcanic extrusions; (ii) detachment faulting in the distal part of the margins allowing exhumation; (iii) volcanic constructions in the exhumation domain; (iv) a complex proto-oceanic crust. We highlight a significant second-order segmentation characterized by six N20°E trending transfer zones, limiting seven 25 - 60 km length segments and affecting necking domain as well as the ocean-continent transition. Based on interpretative cross-sections and detailed stratigraphic analysis, we discuss the complex temporal and spatial evolution of conjugate margins: (i) the margins segmentation and the relationship with structural inheritance (ii) the set-up of a long-offset detachment fault and the nature of the exhumed basement (iv) the origin and timing of magmatic events and the onset of proto-oceanic crust.

FLUID EVOLUTION AND MINERAL REACTIONS DURING SHEAR ZONE FORMATION AT NUSFJORD, LOFOTEN, NORWAY (Invited)

NASA Astrophysics Data System (ADS)

Kullerud, K.

2009-12-01

At Nusfjord in Lofoten, Norway, three 0.3 - 3 m thick shear zones occur in a gabbro-anorthosite. During deformation, the shear zones were infiltrated by a hydrous fluid enriched in Cl. In the central parts of the shear zones, fluid-rock interaction resulted in complete break-down of the primary mafic silicates. Complete hydration of these minerals to Cl-free amphibole and biotite suggests that the hydrous fluid was present in excess during deformation in these parts of the shear zones. Along the margins of the shear zones, however, the igneous mafic silicates (Cpx, Bt, Opx) were only partly overgrown by hydrous minerals. Here, Cl-enriched minerals (Amph, Bt, Scp, Ap) can be observed. Amphibole shows compositions covering the range 0.1 - 4.0 wt % Cl within single thin sections. Mineral textures and extreme compositional variations of the Cl-bearing minerals indicate large chemical gradients of the fluid phase. Relics of primary mafic silicates and compositionally zoned reaction coronas around primary mafic silicates suggest that the free fluid was totally consumed before the alteration of the primary phases were completed. The extreme variations in the Cl-content of amphibole are inferred to monitor a gradual desiccation of the Cl-bearing grain-boundary fluid during fluid-mineral reactions accordingly: 1) The first amphibole that formed during the reactions principally extracted water from the fluid, resulting in a slight increase in the Cl content of the fluid. 2) Continued amphibole-forming reactions resulted in gradual consumption of the free fluid phase, principally by extracting water from the fluid, resulting in an increase in its Cl-content. Higher Cl-content of the fluid resulted in higher Cl-content of the equilibrium amphibole. 3) The most Cl-enriched amphibole (4 wt % Cl) formed in equilibrium with the last volumes of the grain-boundary fluid, which had evolved to a highly saline solution. Mineral reactions within a 1-2 thick zone of the host rock along the contact to the shear zones indicate a more complicated involvement of fluids during shear zone formation than described above. Apparently, fluids have been transported laterally from the outer parts of the shear zones into the gabbro-anorthosite along thin recrystallized zones of plagioclase. The fluid that infiltrated the undeformed host rock of the shear zones resulted in formation of Cl-free amphibole and garnet between the primary mafic minerals and plagioclase. A working hypothesis is that narrow fractures formed within the host rock, outside the sheared rock during shear zone formation. During shear zone formation, the central parts of the shear zones were completely hydrated by an externally derived Cl-bearing hydrous fluid. Some of the fluid migrated to the marginal parts of the shear zones and evolved to a highly saline solution. However, during desiccation of the fluid along the marginal parts of the shear zones, some of the fluid escaped along narrow fractures into the host rock of the shear zones. The Cl-free amphibole that formed from this fluid suggests that the narrow pathways of the fluid provided a path for water transport, but acted as a filter for the much larger ions of Cl.

Deciphering the Influence of Crustal Flexure and Shear Along the Margins of the Eastern Snake River Plain

NASA Astrophysics Data System (ADS)

Parker, S. D.

2016-12-01

The kinematic evolution of the eastern Snake River Plain (ESRP) remains highly contested. A lack of strike-slip faults bounding the ESRP serves as a primary assumption in many leading kinematic models. Recent GPS geodesy has highlighted possible shear zones along the ESRP yet regional strike-slip faults remain unidentified. Oblique movement within dense arrays of high-angle conjugate normal faults, paralleling the ESRP, occur within a discrete zone of 50 km on both margins of the ESRP. These features have long been attributed to progressive crustal flexure and subsidence within the ESRP, but are capable of accommodating the observed strain without necessitating large scale strike-slip faults. Deformation features within an extensive Neogene conglomerate provide field evidence for dextral shear in a transtensional system along the northern margin of the ESRP. Pressure-solution pits and cobble striations provide evidence for a horizontal ENE/WSW maximum principal stress orientation, consistent with the hypothesis of a dextral Centennial shear zone. Fold hinges, erosional surfaces and stratigraphic datums plunging perpendicular into the ESRP have been attributed to crustal flexure and subsidence of the ESRP. Similar Quaternary folds plunge obliquely into the ESRP along its margins where diminishing offset along active normal faults trends into linear volcanic features. In all cases, orientations and distributions of plunging fold structures display a correlation to the terminus of active Basin and Range faults and linear volcanic features of the ESRP. An alternative kinematic model, rooted in kinematic disparities between Basin and Range faults and parallelling volcanic features may explain the observed downwarping as well as provide a mechanism for the observed shear along the margins of the ESRP. By integrating field observations with seismic, geodetic and geomorphic observations this study attempts to decipher the signatures of crustal flexure and shear along the margins of the ESRP. Decoupling the influence of these distinct processes on deformation features bounding the ESRP will aid in our understanding of the kinematic evolution of this highly complex region.

MIZEX. A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. III. Modeling the Marginal Ice Zone,

DTIC Science & Technology

1984-04-01

Ii TS C]r.I2 TAB 0] Unzanro’ unoed 0 justi fica ~r: 0 April 1984 vs - ASValabilitY Codes lvyall and/or U.S. Army Cold Regions Research and Engineering...coupled model. Fig. 1. Annual average simulated velocity fields. 3 192 Aloka 190 / 902 190+ WOO S’,. o Ice OnlY Mod" D"’, 55*w F~tth Yea’ Ice Ocean Model...A more precise delinga- inflow boundary conditions. 12 4- a. [ o ll ii traspert 00 0 0- 0e a I " i i , - - I I 1161 63 15 67 69 Ti 73 75 77 1980 *= 4h

Gastric marginal zone lymphoma of mucosa-associated lymphoid tissue and signet ring cell carcinoma, synchronous collision tumour of the stomach: a case report.

PubMed

George, Smiley Annie; Junaid, T A

2014-01-01

To report a rare case of synchronous marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) signet ring cell carcinoma occurring as a collision tumour in the stomach. A 53-year-old man was diagnosed initially with signet ring cell carcinoma of the stomach. The microscopy of the subsequent total gastrectomy revealed a collision tumour of MALT lymphoma and signet ring cell carcinoma associated with Helicobacter pylori gastritis. This case highlighted the importance of a careful evaluation of the accompanying lymphoid population in the biopsy samples of gastric adenocarcinoma and underlined the need for multiple endoscopic biopsies to detect these rare synchronous tumours. © 2013 S. Karger AG, Basel.

Gastric Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue and Signet Ring Cell Carcinoma, Synchronous Collision Tumour of the Stomach: A Case Report

PubMed Central

George, Smiley Annie; Junaid, T.A.

2014-01-01

Objective To report a rare case of synchronous marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) signet ring cell carcinoma occurring as a collision tumour in the stomach. Clinical Presentation and Intervention A 53-year-old man was diagnosed initially with signet ring cell carcinoma of the stomach. The microscopy of the subsequent total gastrectomy revealed a collision tumour of MALT lymphoma and signet ring cell carcinoma associated with Helicobacter pylori gastritis. Conclusion This case highlighted the importance of a careful evaluation of the accompanying lymphoid population in the biopsy samples of gastric adenocarcinoma and underlined the need for multiple endoscopic biopsies to detect these rare synchronous tumours. PMID:24247357

Poor prognosis in non-villous splenic marginal zone cell lymphoma is associated with p53 mutations.

PubMed

Baldini, L; Guffanti, A; Cro, L; Fracchiolla, N S; Colombi, M; Motta, M; Maiolo, A T; Neri, A

1997-11-01

We have recently reported a series of 15 non-villous splenic marginal zone lymphoma patients, six of whom showed p53 mutations (40%). This molecular alteration did not correlate with any particular clinico-pathologic feature at diagnosis. After a median follow-up of 56 months, four cases evolved into aggressive fatal non-Hodgkin's lymphoma (NHL) and two had refractory progressive disease; interestingly, p53 mutations were demonstrated in five of these patients at diagnosis. As the patients with wild-type p53 presented responsive or indolent disease, this genetic alteration may be an early marker of aggressive transformation or refractoriness. p53 evaluation at diagnosis could be advisable in this particular subset of NHL.

Evolution of microwave sea ice signatures during early summer and midsummer in the marginal ice zone

NASA Technical Reports Server (NTRS)

Onstott, R. G.; Grenfell, T. C.; Matzler, C.; Luther, C. A.; Svendsen, E. A.

1987-01-01

Emissivities at frequencies from 5 to 94 GHz and backscatter at frequencies from 1 to 17 GHz were measured from sea ice in Fram Strait during the marginal Ice Zone Experiment in June and July of 1983 and 1984. The ice observed was primarily multiyear; the remainder, first-year ice, was often deformed. Results from this active and passive microwave study include the description of the evolution of the sea ice during early summer and midsummer; the absorption properties of summer snow; the interrelationship between ice thickness and the state and thickness of snow; and the modulation of the microwave signature, especially at the highest frequencies, by the freezing of the upper few centimeters of the ice.

Evaluating the Potential of Marginal Land for Cellulosic Feedstock Production and Carbon Sequestration in the United States.

PubMed

Emery, Isaac; Mueller, Steffen; Qin, Zhangcai; Dunn, Jennifer B

2017-01-03

Land availability for growing feedstocks at scale is a crucial concern for the bioenergy industry. Feedstock production on land not well-suited to growing conventional crops, or marginal land, is often promoted as ideal, although there is a poor understanding of the qualities, quantity, and distribution of marginal lands in the United States. We examine the spatial distribution of land complying with several key marginal land definitions at the United States county, agro-ecological zone, and national scales, and compare the ability of both marginal land and land cover data sets to identify regions for feedstock production. We conclude that very few land parcels comply with multiple definitions of marginal land. Furthermore, to examine possible carbon-flow implications of feedstock production on land that could be considered marginal per multiple definitions, we model soil carbon changes upon transitions from marginal cropland, grassland, and cropland-pastureland to switchgrass production for three marginal land-rich counties. Our findings suggest that total soil organic carbon changes per county are small, and generally positive, and can influence life-cycle greenhouse gas emissions of switchgrass ethanol.

Lithospheric strength variations as a control on new plate boundaries: examples from the northern Red Sea region

NASA Astrophysics Data System (ADS)

Steckler, Michael S.; ten Brink, Uri S.

1986-08-01

The complex plate boundary between Arabia and Africa at the northern end of the Red Sea includes the Gulf of Suez rift and the Gulf of Aqaba—Dead Sea transform. Geologic evidence indicates that during the earliest phase of rifting the Red Sea propagated NNW towards the Mediterranean Sea creating the Gulf of Suez. Subsequently, the majority of the relative movement between the plates shifted eastward to the Dead Sea transform. We propose that an increase in the strength of the lithosphere across the Mediterranean continental margin acted as a barrier to the propagation of the rift. A new plate boundary, the Dead Sea transform formed along a zone of minimum strength. We present an analysis of lithospheric strength variations across the Mediterranean continental margin. The main factors controlling these variations are the geotherm, crustal thickness and composition, and sediment thickness. The analysis predicts a characteristic strength profile at continental margins which consists of a marked increase in strength seaward of the hinge zone and a strength minimum landward of the hinge zone. This strength profile also favors the creation of thin continental slivers such as the Levant west of the Dead Sea transform and the continental promontory containing Socotra Island at the mouth of the Gulf of Aden. Calculations of strength variations based on changes of crustal thickness, geotherm and sediment thickness can be extended to other geologic settings as well. They can explain the location of rerifting events at intracratonic basins, of backarc basins and of major continental strike-slip zones.

Subduction Zone Dewatering at the Southern End of New Zealand's Hikurangi Margin - Insights from 2D Seismic Tomography

NASA Astrophysics Data System (ADS)

Crutchley, G. J.; Klaeschen, D.

2016-12-01

The southern end of New Zealand's Hikurangi subduction margin is characterised by highly-oblique convergence as it makes a southward transition into a right-lateral transform plate boundary. Long-offset seismic data that cross part of the offshore portion of this transition zone give new insight into the nature of the margin. We have carried out two-dimensional pre-stack depth migrations with an iterative reflection tomography to update the velocity field on two seismic lines in this area. The depth-migrated sections show much-improved imaging of faulting within the wedge, and the seismic velocities themselves give clues about the distribution of gas and/or overpressured regions at the plate boundary and within the overlying wedge. A fascinating observation is a major splay fault that has been (or continues to be) a preferred dewatering pathway through the wedge, evidenced by a thermal anomaly that has left its mark on the overlying gas hydrate layer. Another interesting observation is a thick and laterally extensive low velocity zone beneath the subduction interface, which might have important implications for the long-term mechanical stability of the interface. Our on-going work on these data is focused on amplitude versus offset analysis in an attempt to better understand the nature of the subduction interface and also the shallower gas hydrate system. This study is an example of how distinct disturbances of the gas hydrate system can provide insight into subduction zone fluid flow processes that are important for understanding wedge stability and ultimately earthquake hazard.

The effect of diagenesis and fluid migration on rare earth element distribution in pore fluids of the northern Cascadia accretionary margin

USGS Publications Warehouse

Kim, Ji-Hoon; Torres, Marta E.; Haley, Brian A.; Kastner, Miriam; Pohlman, John W.; Riedel, Michael; Lee, Young-Joo

2012-01-01

Analytical challenges in obtaining high quality measurements of rare earth elements (REEs) from small pore fluid volumes have limited the application of REEs as deep fluid geochemical tracers. Using a recently developed analytical technique, we analyzed REEs from pore fluids collected from Sites U1325 and U1329, drilled on the northern Cascadia margin during the Integrated Ocean Drilling Program (IODP) Expedition 311, to investigate the REE behavior during diagenesis and their utility as tracers of deep fluid migration. These sites were selected because they represent contrasting settings on an accretionary margin: a ponded basin at the toe of the margin, and the landward Tofino Basin near the shelf's edge. REE concentrations of pore fluid in the methanogenic zone at Sites U1325 and U1329 correlate positively with concentrations of dissolved organic carbon (DOC) and alkalinity. Fractionations across the REE series are driven by preferential complexation of the heavy REEs. Simultaneous enrichment of diagenetic indicators (DOC and alkalinity) and of REEs (in particular the heavy elements Ho to Lu), suggests that the heavy REEs are released during particulate organic carbon (POC) degradation and are subsequently chelated by DOC. REE concentrations are greater at Site U1325, a site where shorter residence times of POC in sulfate-bearing redox zones may enhance REE burial efficiency within sulfidic and methanogenic sediment zones where REE release ensues. Cross-plots of La concentrations versus Cl, Li and Sr delineate a distinct field for the deep fluids (z > 75 mbsf) at Site U1329, and indicate the presence of a fluid not observed at the other sites drilled on the Cascadia margin. Changes in REE patterns, the presence of a positive Eu anomaly, and other available geochemical data for this site suggest a complex hydrology and possible interaction with the igneous Crescent Terrane, located east of the drilled transect.

Improved Nazca slab structure from teleseismic P-wave tomography along the Andean margin

NASA Astrophysics Data System (ADS)

Portner, D. E.; Beck, S. L.; Scire, A. C.; Zandt, G.

2017-12-01

South America marks the longest continuous ocean-continent subduction zone. As such, there is significant along-strike variability in the subducting Nazca slab structure and the tectonics of the South American margin. Most notably two gaps in the otherwise continuous volcanic arc are correlated with regions of flat slab subduction, indicating that the structure of the Nazca slab plays a controlling role in South American tectonics. Traditionally in subduction zones, our knowledge of slab structure is defined by Wadati-Benioff zone earthquakes. While this method allows for the determination of large-scale variations in Nazca slab structure such as regions of flat slab subduction, a scarcity of intermediate-depth earthquakes hinders our ability to observe the smaller-scale structural variations in the slab that may be critical to our understanding of the geologic record. We use an updated, larger dataset for finite-frequency teleseismic P-wave tomography including relative arrival times from >700 seismic stations along the Andean margin to image the detailed Nazca slab structure throughout the upper mantle and uppermost lower mantle between latitudes 5°S and 45°S. Our results show prominent variations in slab character along the margin. Slab dip varies significantly, from sub-vertical inboard of the Peruvian flat slab segment to 30° dip south of the Pampean flat slab, while the slab's velocity anomaly amplitude changes dramatically near the Pampean flat slab region. High slab velocities north of the Pampean region relative to the south indicate variable slab thermal structures that correspond roughly with the locations of deep (>500 km depth) earthquakes that also occur exclusively north of the Pampean region. Additionally, a wider regional footprint increases our sampling of the upper-lower mantle boundary, improving constraints on the slab's interaction with the 660 km discontinuity along strike. We see that the Nazca slab appears to penetrate into the lower mantle along the majority of the margin.

Ocean Profile Measurements During the Seasonal Ice Zone Reconnaissance Surveys Ocean Profiles

DTIC Science & Technology

2017-01-01

repeated ocean, ice, and atmospheric measurements across the Beaufort-Chukchi sea seasonal sea ice zone (SIZ) utilizing US Coast Guard Arctic Domain...contributing to the rapid decline in summer ice extent that has occurred in recent years. The SIZ is the region between maximum winter sea ice extent and...minimum summer sea ice extent. As such, it contains the full range of positions of the marginal ice zone (MIZ) where sea ice interacts with open water

Reconstruction of the pre-breakup crustal thickness in Australia/Antarctica

NASA Astrophysics Data System (ADS)

Goncharov, A.

2003-04-01

Some 140 million years ago, Australia and Antarctica were parts of a single continent Gondwana. Before it broke into parts there was a process of extensive crustal extension. Thinning of the crust during this process was accompanied by deposition of vast amounts of sedimentary rocks along Australia’s Southern Margin, where the total sediment thickness locally (e.g., Ceduna Sub-basin) reaches 15 km. These sedimentary rocks may have been involved in oil and gas formation. Knowledge of the pre-breakup crustal thickness in Australia/Antarctica is important because it provides additional constraints for plate tectonic reconstructions of the two continents and ultimately leads to a more accurate assessment of the petroleum potential of Australia’s Southern Margin. Most reliable estimates of crustal thickness come from refraction seismic measurements which define the depth to the Moho boundary, where seismic velocity increases to 8 km/s or more. Such measurements were used in this research for Australia. Unlike Australia, Antarctica has poor coverage of seismic measurements of crustal thickness. For Antarctica, seismic measurements were supplemented by values predicted by the regression between seismically defined crustal thickness and upwardly continued gravity. Upward continuation emphasizes the effects of variations in crustal thickness in the total gravity signal. After compilation and computation of crustal thickness was completed, data points located on Australian continent were reconstructed to their pre-breakup position. The most up-to-date finite rotation parameters defining the movement of Australia relative to Antarctica were used in this process. To ensure that pre-breakup extension and thinning of the crust (during the 140 to 95 Ma time interval) were accounted for, points with crustal thickness values less than 30 km on both Australian and Antarctic margins were excluded from subsequent gridding. Crust thinner than 30 km was taken to have been affected by pre-breakup extension. The resultant reconstructed pre-extensional crustal thickness may have existed in this part of Gondwana prior to the pre-breakup extension, assuming that geological processes on both continents (excluding margins) have not affected it significantly since then. Crustal thickness along the zone of subsequent Australia/Antarctica separation is clearly reduced and its width varies substantially. Thin crust is generally weaker than thick crust, so it is not surprising that the continents broke apart along this zone. A distinct zone of thick crust, which spans across Australia/Antarctica from the Eastern Highlands in Australia to the Transantarctic Mountains, is another obvious feature on the map of pre-extensional crustal thickness. This may explain why the break-up of the continents between Tasmania and Northern Victoria Land occurred as the last stage of the separation process. Thick crust in this region essentially served as a lock: only after this lock was broken did final separation occur. Clearly, thickest sediment has accumulated where the width of the zone of pre-extensional thin crust was minimal in the Ceduna Sub-basin. This may be due to the higher rate of subsidence in the zone with the steepest slope on the Moho. Rheology of the crust and sediment supply were also among the contributing factors; relative contributions of these factors will be studied in more detail in the future. Sedimentation in the Otway, Sorell, Bass and Gippsland basins to the north and west of Tasmania, unlike other basins on the Southern Margin, commenced in a thick crust environment: all four are located within the Eastern Highlands - Transantarctic Mountains zone. Although, crustal thickness immediately underneath the basins is not much different from the western part of the Margin, clearly there are two prominent (up to 45 km) Moho lows to the north and south of them. Onset of pre-breakup crustal extension within this zone was probably different from the western part of the Southern Margin: thicker crust is harder to break. Also, thicker crust generally means higher heat flow. These differences may have affected both the style of crustal extension and hydrocarbon maturation in deposited sediments. Non-uniform pre-extensional crustal thickness along Australian Southern and conjugate Antarctic margins, as well as implied differences in heat flow distribution, must be taken into consideration in modelling crustal extension and the formation of sedimentary basins.

Pembrolizumab in Untreated B-Cell Non-Hodgkin Lymphoproliferative Diseases

ClinicalTrials.gov

2018-04-06

B-Cell Non-Hodgkin Lymphoma; Waldenstrom Macroglobulinemia; Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma; Lymphoplasmacytic Lymphoma; Follicular Lymphoma; Indolent Non-Hodgkin Lymphoma; Marginal Zone Lymphoma

Deep structure of the continental margin and basin off Greater Kabylia, Algeria - New insights from wide-angle seismic data modeling and multichannel seismic interpretation

NASA Astrophysics Data System (ADS)

Aïdi, Chafik; Beslier, Marie-Odile; Yelles-Chaouche, Abdel Karim; Klingelhoefer, Frauke; Bracene, Rabah; Galve, Audrey; Bounif, Abdallah; Schenini, Laure; Hamai, Lamine; Schnurle, Philippe; Djellit, Hamou; Sage, Françoise; Charvis, Philippe; Déverchère, Jacques

2018-03-01

During the Algerian-French SPIRAL survey aimed at investigating the deep structure of the Algerian margin and basin, two coincident wide-angle and reflection seismic profiles were acquired in central Algeria, offshore Greater Kabylia, together with gravimetric, bathymetric and magnetic data. This 260 km-long offshore-onshore profile spans the Balearic basin, the central Algerian margin and the Greater Kabylia block up to the southward limit of the internal zones onshore. Results are obtained from modeling and interpretation of the combined data sets. The Algerian basin offshore Greater Kabylia is floored by a thin oceanic crust ( 4 km) with P-wave velocities ranging between 5.2 and 6.8 km/s. In the northern Hannibal High region, the atypical 3-layer crustal structure is interpreted as volcanic products stacked over a thin crust similar to that bordering the margin and related to Miocene post-accretion volcanism. These results support a two-step back-arc opening of the west-Algerian basin, comprising oceanic crust accretion during the first southward stage, and a magmatic and probably tectonic reworking of this young oceanic basement during the second, westward, opening phase. The structure of the central Algerian margin is that of a narrow ( 70 km), magma-poor rifted margin, with a wider zone of distal thinned continental crust than on the other margin segments. There is no evidence for mantle exhumation in the sharp ocean-continent transition, but transcurrent movements during the second opening phase may have changed its initial geometry. The Plio-Quaternary inversion of the margin related to ongoing convergence between Africa and Eurasia is expressed by a blind thrust system under the margin rising toward the surface at the slope toe, and by an isostatic disequilibrium resulting from opposite flexures of two plates decoupled at the continental slope. This disequilibrium is likely responsible for the peculiar asymmetrical shape of the crustal neck that may thus be a characteristic feature of inverted rifted margins.

First pediatric experience of SL-401, a CD123-targeted therapy, in patients with blastic plasmacytoid dendritic cell neoplasm: report of three cases.

PubMed

Sun, Weili; Liu, Huaying; Kim, Young; Karras, Nicole; Pawlowska, Anna; Toomey, Debbie; Kyono, Wade; Gaynon, Paul; Rosenthal, Joseph; Stein, Anthony

2018-05-02

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly aggressive hematological malignancy with extremely poor outcome. The median overall survival for adult patients is 9-13 months. Pediatric patients are exceedingly rare with an unclear clinical course. Currently, no standardized therapy has been established, although an acute lymphoblastic leukemia type of treatment appears to be more effective in those patients who are able to tolerate aggressive chemotherapy. SL-401 is a targeted therapy directed to CD123, a protein ubiquitously expressed at high level on the surface of BPDCN blasts. In adult phase 2 trials, it has demonstrated efficacy with 90% overall response rate. No pediatric patients with BPDCN using SL-401 have been reported. Here, we report the first pediatric experience of three children with BPDCN treated with SL-401 at our institution. All patients tolerated SL-401 without significant toxicities. One patient with multiply relapsed and refractory disease had no response. The other two cases had significant and rapid clinical improvement after the two courses of treatment. However, the response was transient, and growth of soft tissue mass was observed in-between cycles in both patients with large tumor burden. This is the first report of SL-401 in pediatric patients with BPDCN. Sl-401 was well tolerated and can produce a promising response. Further testing this agent in children is warranted.

The Meandering Margin of the Meteorological Moist Tropics

NASA Astrophysics Data System (ADS)

Mapes, Brian E.; Chung, Eui Seok; Hannah, Walter M.; Masunaga, Hirohiko; Wimmers, Anthony J.; Velden, Christopher S.

2018-01-01

Bimodally distributed column water vapor (CWV) indicates a well-defined moist regime in the Tropics, above a margin value near 48 kg m-2 in current climate (about 80% of column saturation). Maps reveal this margin as a meandering, sinuous synoptic contour bounding broad plateaus of the moist regime. Within these plateaus, convective storms of distinctly smaller convective and mesoscales occur sporadically. Satellite data composites across the poleward most margin reveal its sharpness, despite the crude averaging: precipitation doubles within 100 km, marked by both enhancement and deepening of cloudiness. Transported patches and filaments of the moist regime cause consequential precipitation events within and beyond the Tropics. Distinguishing synoptic flows that cross the margin from flows that move the margin is made possible by a novel satellite-based Lagrangian CWV tendency estimate. Climate models do not reliably reproduce the observed bimodal distribution, so studying the moist mode's maintenance processes and the margin-zone air mass transformations, guided by the Lagrangian tendency product, might importantly constrain model moist process treatments.

An investigation of deformation and fluid flow at subduction zones using newly developed instrumentation and finite element modeling

NASA Astrophysics Data System (ADS)

Labonte, Alison Louise

Detecting seafloor deformation events in the offshore convergent margin environment is of particular importance considering the significant seismic hazard at subduction zones. Efforts to gain insight into the earthquake cycle have been made at the Cascadia and Costa Rica subduction margins through recent expansions of onshore GPS and seismic networks. While these studies have given scientists the ability to quantify and locate slip events in the seismogenic zone, there is little technology available for adequately measuring offshore aseismic slip. This dissertation introduces an improved flow meter for detecting seismic and aseismic deformation in submarine environments. The value of such hydrologic measurements for quantifying the geodetics at offshore margins is verified through a finite element modeling (FEM) study in which the character of deformation in the shallow subduction zone is determined from previously recorded hydrologic events at the Costa Rica Pacific margin. Accurately sensing aseismic events is one key to determining the stress state in subduction zones as these slow-slip events act to load or unload the seismogenic zone during the interseismic period. One method for detecting seismic and aseismic strain events is to monitor the hydrogeologic response to strain events using fluid flow meters. Previous instrumentation, the Chemical Aqueous Transport (CAT) meter which measures flow rates through the sediment-water interface, can detect transient events at very low flowrates, down to 0.0001 m/yr. The CAT meter performs well in low flow rate environments and can capture gradual changes in flow rate, as might be expected during ultra slow slip events. However, it cannot accurately quantify high flow rates through fractures and conduits, nor does it have the temporal resolution and accuracy required for detecting transient flow events associated with rapid deformation. The Optical Tracer Injection System (OTIS) developed for this purpose is an electronic flow meter that can measure flow rates of 0.1 to >500 m/yr at a temporal resolution of 30 minutes to 0.5 minutes, respectively. Test deployments of the OTIS at cold seeps in the transpressional Monterey Bay demonstrated the OTIS functionality over this range of flow environments. Although no deformation events were detected during these test deployments, the OTIS's temporally accurate measurements at the vigorously flowing Monterey Bay cold seep rendered valuable insight into the plumbing of the seep system. In addition to the capability to detect transient flow events, a primary functional requirement of the OTIS was the ability to communicate and transfer data for long-term real-time monitoring deployments. Real-time data transfer from the OTIS to the desktop was successful during a test deployment of the Nootka Observatory, an acoustically-linked moored-buoy system. A small array of CAT meters was also deployed at the Nootka transform-Cascadia subduction zone triple junction. Four anomalous flow rate events were observed across all four meters during the yearlong deployment. Although the records have low temporal accuracy, a preliminary explanation for the regional changes in flow rate is made through comparison between flow rate records and seismic records. The flow events are thought to be a result of a tectonic deformation event, possibly with an aseismic component. Further constraints are not feasible given the unknown structure of faulting near the triple junction. In a final proof of concept study, I find that use these hydrologic instruments, which capture unique aseismic flow rate patterns, is a valuable method for extracting information about deformation events on the decollement in the offshore subduction zone margin. Transient flow events observed in the frontal prism during a 1999--2000 deployment of CAT meters on the Costa Rica Pacific margin suggest episodic slow-slip deformation events may be occurring in the shallow subduction zone. The FEM study to infer the character of the hypothetical deformation event driving flow transients verify that indeed, a shallow slow-slip event can reproduce the unique flow rate patterns observed. Along (trench) strike variability in the rupture initiation location, and bidirectional propagation, is one way to explain the opposite sign of flow rate transients observed at different along-strike distances. The larger question stimulated by this dissertation project, is: What are the controls on fault mechanics in offshore subduction zone environments? It appears the shallow subduction zone plate interface doesn't behave solely in response to frictional properties of the sediment lining the decollement. Shallow episodic slip at the Costa Rica Pacific margin and further north off Nicaragua, where a slow earthquake broke through the shallow 'stable-sliding' zone and resulted in a tsunami, are potentially conceived through the normally faulted incoming basement topography. Scientists should seek to map out the controls of faulting mechanics, whatever they may be, at all temporal and spatial scales in order to understand these dynamic subduction zone systems. The quest to understanding these controls, in part, requires the characterization of aseismic and seismic strain occurring over time and space. The techniques presented in this dissertation advance scientists' capability for quantifying such strains. With the new instrumentation presented here, long-term real-time observatory networks on the seafloor, and modeling for characterization of deformation events, the pieces of the subduction zone earthquake cycle puzzle may start to come together.

Late Quaternary Faulting along the San Juan de los Planes Fault Zone, Baja California Sur, Mexico

NASA Astrophysics Data System (ADS)

Busch, M. M.; Coyan, J. A.; Arrowsmith, J.; Maloney, S. J.; Gutierrez, G.; Umhoefer, P. J.

2007-12-01

As a result of continued distributed deformation in the Gulf Extensional Province along an oblique-divergent plate margin, active normal faulting is well manifest in southeastern Baja California. By characterizing normal-fault related deformation along the San Juan de los Planes fault zone (SJPFZ) southwest of La Paz, Baja California Sur we contribute to understanding the patterns and rates of faulting along the southwest gulf-margin fault system. The geometry, history, and rate of faulting provide constraints on the relative significance of gulf-margin deformation as compared to axial system deformation. The SJPFZ is a major north-trending structure in the southern Baja margin along which we focused our field efforts. These investigations included: a detailed strip map of the active fault zone, including delineation of active scarp traces and geomorphic surfaces on the hanging wall and footwall; fault scarp profiles; analysis of bedrock structures to better understand how the pattern and rate of strain varied during the development of this fault zone; and a gravity survey across the San Juan de los Planes basin to determine basin geometry and fault behavior. The map covers a N-S swath from the Gulf of California in the north to San Antonio in the south, an area ~45km long and ~1-4km wide. Bedrock along the SJPFZ varies from Cretaceous Las Cruces Granite in the north to Cretaceous Buena Mujer Tonalite in the south and is scarred by shear zones and brittle faults. The active scarp-forming fault juxtaposes bedrock in the footwall against Late Quaternary sandstone-conglomerate. This ~20m wide zone is highly fractured bedrock infused with carbonate. The northern ~12km of the SJPFZ, trending 200°, preserves discontinuous scarps 1-2km long and 1-3m high in Quaternary units. The scarps are separated by stretches of bedrock embayed by hundreds of meters-wide tongues of Quaternary sandstone-conglomerate, implying low Quaternary slip rate. Further south, ~2 km north of the Los Planes highway, the fault steps to the right 2km with no overlap. The fault is inactive until ~3km south of the Los Planes highway where scarp heights in the Quaternary sediments rise to ~3-11m for ~11km with an average trend of 160°, implying increasing slip rate. The fault then steps left 2km with no overlap, trending 145°. Scarp heights range from 3-6m in the step. The southernmost 9km of the fault zone, trending 200°, is marked by discontinuous scarps and embayed bedrock, reflecting diminished fault activity. The footwall landscape in this area is characterized by a broad, gently-sloping, low-relief pediment surface with thin Quaternary cover, disrupted by inselberg-like hills. The young scarp-forming fault appears to have reactivated older faults to rupture this pediment, reflecting the episodic nature of slip along this fault zone. Preliminary OSL ages of the youngest faulted deposit imply a Late Pleistocene-Holocene slip rate of 0.1-1mm/yr. The SJPFZ is thus characterized by reactivation of pre-existing faults to rupture a pre-existing low relief erosional landscape. Whereas the entire region might have experienced the quiescent period that allowed for development of the low- relief, stable surface along the SJPFZ, we speculate that while the SJPFZ was dormant, other faults within the gulf-margin system were actively accommodating strain.

Sn to Sg conversion and focusing along the Atlantic margin, Morocco - Implications for earthquake hazard evaluation

NASA Astrophysics Data System (ADS)

Seber, Dogan; Barazangi, Muawia; Tadili, Ben A.; Ramdani, Mohamed; Ibenbrahim, Aomar; Ben Sari, Driss; El Alami, Sidi O.

1993-07-01

Digital data from a telemetered, short-period seismic network in Morocco provide a new perspective for understanding the cause of severe shaking and macroseismic reports in Morocco produced by large offshore earthquakes located along the Azores-Gibraltar seismic zone. Even though the earthquake epicenters are 500-1000 km away from the Moroccan coast, historical records show that such events are capable of producing considerable damage in inland areas. We analyze 15 earthquakes that occurred in this region. The records show multiple S phases with varying frequencies and amplitudes. The S phase with the largest amplitude, usually misinterpreted as Sn, has a phase velocity of 4.2-4.4 km/s. We show that these S arrivals can best be explained as Sn to Sg converted phases. Calculated locations of the conversion points for these phases exhibit two distinct zones almost parallel to the Atlantic coastline: one is located along the passive continental margin and the other is located about 100 km inland from the coastline. We interpret these two zones to be regions where a sudden change in crustal thickness occurs. Such zones act to focus and magnify the amplitudes of seismic phases.

A comparison of the South China Sea and Canada Basin: two small marginal ocean basins with hyper-extended margins and central zones of sea-floor spreading.

NASA Astrophysics Data System (ADS)

Li, L.

2015-12-01

Both the South China Sea and Canada Basin preserve oceanic spreading centres and adjacent passive continental margins characterized by broad COT zones with hyper-extended continental crust. We have investigated the nature of strain accommodation in the regions immediately adjacent to the oceanic spreading centres in these two basins using 2-D backstripping subsidence reconstructions, coupled with forward modelling constrained by estimates of upper crustal extensional faulting. Modelling is better constrained in the South China Sea but our results for the Beaufort Sea are analogous. Depth-dependent extension is required to explain the great depth of both basins because only modest upper crustal faulting is observed. A weak lower crust in the presence of high heat flow is suggested for both basins. Extension in the COT may continue even after sea-floor spreading has ceased. The analogous results for the two basins considered are discussed in terms of (1) constraining the timing and distribution of crustal thinning along the respective continental margins, (2) defining the processes leading to hyper-extension of continental crust in the respective tectonic settings and (3) illuminating the processes that control hyper-extension in these basins and more generally.

Seismic Evidence for Widespread Serpentinized Forearc Mantle Along the Mariana Convergence Margin

NASA Astrophysics Data System (ADS)

Tibi, R.; Wiens, D. A.

2007-12-01

We use P-to-S converted phases from teleseisms recorded at broadband stations in the Mariana Islands to image the forearc and arc regions of the Mariana convergence margin. The Moho in the subducting Pacific plate is observed at depths between 75 and 110 km beneath the region extending from Rota to Saipan. The S-wave velocity in the subducting crust is inferred to be ~10% slower than the surrounding mantle. This demonstrates that the crust has not yet undergone conversion to eclogite at these depths, in agreement with observations made for other arcs. A low velocity zone (LVZ), approximately 10--25 km thick, whose upper boundary is imaged at about 40--55 km depth, is detected in the forearc region of the mantle wedge along the entire margin. The anomaly is located too shallow to represent subducted oceanic crust. We interpret the LVZ as a serpentinized region in the forearc mantle, resulting from hydration by slab-expelled water. The occurrence of the serpentinized zone along the entire margin suggests that serpentinization of the forearc mantle is a widespread phenomenon in the Mariana arc. The inferred S wave velocity in the LVZ of as low as ~3.6 km/s represents a level of serpentinization of 30--50%, corresponding to a water content of about 4--6 wt%.

Splenic marginal zone lymphoma: excellent outcomes in 64 patients treated in the rituximab era.

PubMed

Starr, Adam G; Caimi, Paolo F; Fu, PingFu; Massoud, Mira R; Meyerson, Howard; Hsi, Eric D; Mansur, David B; Cherian, Sheen; Cooper, Brenda W; De Lima, Marcos J G; Lazarus, Hillard M; Gerson, Stanton L; Jagadeesh, Deepa; Smith, Mitchell R; Dean, Robert M; Pohlman, Brad L; Hill, Brian T; William, Basem M

2017-08-01

Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin lymphoma. We sought to identify prognostic factors and define outcomes in a cohort of 64 patients with SMZL who were treated at two large academic medical centers in North America in the rituximab era. Over a median follow-up of 37.8 (range 6-167.1) months, Kaplan-Meier estimate of median OS was 156.3 months and median PFS was 52.9 months. On univariate analysis, baseline hemoglobin <12 g/dl was associated with inferior OS (p = 0.045). High-risk FLIPI score was associated with inferior PFS when compared with intermediate/low risk (p = 0.05) and marginally significant with regard to OS (p = 0.056). Splenectomy was not predictive of OS or PFS (p = 0.563 and 0.937, respectively). Transformation to diffuse large B-cell lymphoma occurred in four (6.3%) patients during the observation period. OS was comparable to contemporaneous cohorts of patients with extranodal and nodal marginal lymphomas and FLIPI score was highly predictive for inferior PFS and OS when all three cohorts were analyzed together. Outcomes of SMZL, in our series, were excellent, with a median OS of >13 years. Low hemoglobin and high-risk FLIPI were associated with inferior outcomes.

Study of crustal structure and stretch mechanism of central continental shelf of northern South China Sea

NASA Astrophysics Data System (ADS)

Cao, J.; Xia, S.; Sun, J.; Wan, K.; Xu, H.

2017-12-01

Known as a significant region to study tectonic relationship between South China block and South China Sea (SCS) block and the evolution of rifted basin in continental margin, the continental shelf of northern SCS documents the evolution from continental splitting to seafloor spreading of SCS. To investigate crustal structure of central continental shelf in northern SCS, two wide-angle onshore-offshore seismic experiments and coincident multi-channel seismic (MCS) profiles were carried out across the onshore-offshore transitional zone in northern SCS, 2010 and 2012. A total of 34 stations consisted of ocean bottom seismometers, portable and permanent land stations were deployed during the survey. The two-dimensional precise crustal structure models of central continental shelf in northern SCS was constructed from onshore to offshore, and the stretching factors along the P-wave velocity models were calculated. The models reveal that South China block is a typical continental crust with a 30-32 km Moho depth, and a localized high-velocity anomaly in middle-lower crust under land area near Hong Kong was imaged, which may reflect magma underplating caused by subduction of paleo-Pacific plate in late Mesozoic. The littoral fault zone is composed of several parallel, high-angle, normal faults that mainly trend northeast to northeast-to-east and dip to the southeast with a large displacement, and the fault is divided into several segments separated by the northwest-trending faults. The shelf zone south of LFZ was consisted of a differential thinning upper and lower continental crust, which indicate stretch thinning of passive continent margin during the Cenozoic spreading of the SCS. The results appear to further confirm that the northern margin of SCS experienced a transition from active margin to passive one during late Mesozoic and Cenozoic.

On the feedback between forearc morphotectonics and megathrust earthquakes in subduction zones

NASA Astrophysics Data System (ADS)

Rosenau, M.; Oncken, O.

2008-12-01

An increasing number of observations suggest an intrinsic relationship between short- and long-term deformation processes in subduction zones. These include the global correlation between megathrust earthquake slip patterns with morphotectonic forearc features, the historical predominance of giant earthquakes (M > 9) along accretionary margins and the occurrence of (slow and shallow) tsunami earthquakes along erosive margins. To gain insight into the interplay between seismogenesis and tectonics in subduction settings we have developed a new modeling technique which joins analog and elastic dislocation approaches. Using elastoplastic wedges overlying a rate- and state-dependent interface, we demonstrate how analog earthquakes drive permanent wedge deformation consistent with the dynamic Coulomb wedge theory and how wedge deformation in turn controls basal "seismicity". During an experimental run, elastoplastic wedges evolve from those comparable to accretionary margins, characterized by plastic wedge shortening, to those mimicking erosive margins, characterized by minor plastic deformation. Permanent shortening localizes at the periphery of the "seismogenic" zone leading to a "morphotectonic" segmentation of the upper plate. Along with the evolving segmentation of the wedge, the magnitude- frequency relationship and recurrence distribution of analog earthquakes develop towards more periodic events of similar size (i.e. characteristic earthquakes). From the experiments we infer a positive feedback between short- and long-term deformation processes which tends to stabilize the spatiotemporal patterns of elastoplastic deformation in subduction settings. We suggest (1) that forearc anatomy reflects the distribution of seismic and aseismic slip at depth, (2) that morphotectonic segmentation assists the occurrence of more characteristic earthquakes, (3) that postseismic near-trench shortening relaxes coseismic compression by megathrust earthquakes and thus reduces tsunami earthquake risk in accretionary settings and (4) that permanent coastal shortening allows adjacent segments to fail more synchronized thus triggering much greater earthquakes in accretionary settings.

Repeated large-scale retreat and advance of Totten Glacier indicated by inland bed erosion.

PubMed

Aitken, A R A; Roberts, J L; van Ommen, T D; Young, D A; Golledge, N R; Greenbaum, J S; Blankenship, D D; Siegert, M J

2016-05-19

Climate variations cause ice sheets to retreat and advance, raising or lowering sea level by metres to decametres. The basic relationship is unambiguous, but the timing, magnitude and sources of sea-level change remain unclear; in particular, the contribution of the East Antarctic Ice Sheet (EAIS) is ill defined, restricting our appreciation of potential future change. Several lines of evidence suggest possible collapse of the Totten Glacier into interior basins during past warm periods, most notably the Pliocene epoch, causing several metres of sea-level rise. However, the structure and long-term evolution of the ice sheet in this region have been understood insufficiently to constrain past ice-sheet extents. Here we show that deep ice-sheet erosion-enough to expose basement rocks-has occurred in two regions: the head of the Totten Glacier, within 150 kilometres of today's grounding line; and deep within the Sabrina Subglacial Basin, 350-550 kilometres from this grounding line. Our results, based on ICECAP aerogeophysical data, demarcate the marginal zones of two distinct quasi-stable EAIS configurations, corresponding to the 'modern-scale' ice sheet (with a marginal zone near the present ice-sheet margin) and the retreated ice sheet (with the marginal zone located far inland). The transitional region of 200-250 kilometres in width is less eroded, suggesting shorter-lived exposure to eroding conditions during repeated retreat-advance events, which are probably driven by ocean-forced instabilities. Representative ice-sheet models indicate that the global sea-level increase resulting from retreat in this sector can be up to 0.9 metres in the modern-scale configuration, and exceeds 2 metres in the retreated configuration.

Postextraction Dental Implant in the Aesthetic Zone, Socket Shield Technique Versus Conventional Protocol.

PubMed

Bramanti, Ennio; Norcia, Antonio; Cicciù, Marco; Matacena, Giada; Cervino, Gabriele; Troiano, Giuseppe; Zhurakivska, Khrystyna; Laino, Luigi

2018-06-01

The aim of this randomized controlled trial was to evaluate the survival rate, the marginal bone level, and the aesthetic outcome; at 3 years' follow-up, of dental implants placed into a high-esthetic aesthetic zone by comparing 2 techniques of postextraction implant with immediate loading: the socket shied technique and the conventional insertion technique.Several clinical studies suggested that the avulsion of a dental element causes dimensional alterations of both soft and hard tissues at the postextractive site. To increase the aesthetic outcomes, the "socket-shield technique" has been proposed. This method involves maintaining the vestibular root portion and immediate insertion of the dental implant in close proximity to the root.Patients enrolled in this study were randomized to receive a postextraction implant in the aesthetic zone, either with the socket shied technique or with the conventional insertion technique. Implant survival, marginal bone level, and the pink aesthetic score were the outcomes evaluated.Implant survival rate was 100% in both the groups at 3 years. Implants inserted with the socket shield technique showed better values of both marginal bone level and pink aesthetic score (P < 0.05).Although such preliminary results need to be further confirmed, the socket shield technique seems to be a safe surgical technique that allows an implant rehabilitation characterized by better aesthetic outcomes.

DNA Microarray Gene Expression Profile of Marginal Zone versus Follicular B cells and Idiotype Positive Marginal Zone B cells Before and After Immunization with Streptococcus pneumoniae 1

PubMed Central

Liu, Jiabin; Behrens, Timothy W.; Kearney, John F.

2014-01-01

Marginal Zone (MZ) B cells play an important role in the clearance of blood-borne bacterial infections via rapid T-independent IgM responses. We have previously demonstrated that MZ B cells respond rapidly and robustly to bacterial particulates. To determine the MZ-specific genes that are expressed to allow for this response, MZ and Follicular (FO) B cells were sort-purified and analyzed via DNA microarray analysis. We identified 181 genes that were significantly different between the two B cell populations. 99 genes were more highly expressed in MZ B cells while 82 genes were more highly expressed in FO B cells. To further understand the molecular mechanisms by which MZ B cells respond so rapidly to bacterial challenge, idiotype positive and negative MZ B cells were sort-purified before (0 hour) or after (1 hour) i.v. immunization with heat killed Streptococcus pneumoniae, R36A, and analyzed via DNA microarray analysis. We identified genes specifically up regulated or down regulated at 1 hour following immunization in the idiotype positive MZ B cells. These results give insight into the gene expression pattern in resting MZ vs. FO B cells and the specific regulation of gene expression in antigen-specific MZ B cells following interaction with antigen. PMID:18453586

IgV(H) and bcl6 somatic mutation analysis reveals the heterogeneity of cutaneous B-cell lymphoma, and indicates the presence of undisclosed local antigens.

PubMed

Franco, Renato; Camacho, Francisca I; Fernández-Vázquez, Amalia; Algara, Patrocinio; Rodríguez-Peralto, José L; De Rosa, Gaetano; Piris, Miguel A

2004-06-01

Our understanding of the ontology of B-cell lymphomas (BCL) has been improved by the study of mutational status of IgV(H) and bcl6 genes, but only a few cases of cutaneous BCL have been examined for this status. We analyzed IgV(H) and bcl6 somatic mutations in 10 cutaneous BCL, classified as follicular (three primary and one secondary), primary marginal zone (two cases), and diffuse large BCL (three primary and one secondary). We observed a lower rate (<2%) of IgV(H) mutation in all marginal zone lymphomas, and a preferential usage of V(H)2-70 (one primary follicular and two primary diffuse large BCL). Fewer than expected replacement mutations in framework regions (FR) were observed in three primary follicular lymphomas (FLs) and in all diffuse large BCL, indicating a negative antigen selection pressure. Ongoing mutations were observed in eight of 10 cases. Only two primary FLs and two diffuse large BCL showed bcl6 somatic mutation. These data support the heterogeneous nature of the different cutaneous BCL, and specifically the distinction between cutaneous follicular and marginal zone lymphomas. The biased usage of V(H)2-70, the low rate of replacement mutation in the FR, and the presence of ongoing mutation imply that local antigens could modulate the growth of primary cutaneous BCL.

Entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kao, K.R.; Elinson, R.P.

1988-05-01

The body plan of Xenopus laevis can be respecified by briefly exposing early cleavage stage embryos to lithium. Such embryos develop exaggerated dorsoanterior structures such as a radial eye and cement gland. In this paper, we demonstrate that the enhanced dorsoanterior phenotype results from an overcommitment of mesoderm to dorsoanterior mesoderm. Histological and immunohistochemical observations reveal that the embryos have a greatly enlarged notochord with very little muscle tissue. In addition, they develop a radial, beating heart, suggesting that lithium also specifies anterior mesoderm and pharyngeal endoderm. Randomly oriented diametrically opposed marginal zone grafts from lithium-treated embryos, when transplanted intomore » ultraviolet (uv)-irradiated axis-deficient hosts, rescue dorsal axial structures. These transplantation experiments demonstrate that the entire marginal zone of the early gastrula consists of presumptive dorsal mesoderm. Vital dye marking experiments also indicate that the entire marginal zone maps to the prominent proboscis that is composed of chordamesoderm and represents the long axis of the embryo. These results suggest that lithium respecifies the mesoderm of Xenopus laevis embryos so that it differentiates into the Spemann organizer. We suggest that the origin of the dorsoanterior enhanced phenotypes generated by lithium and the dorsoanterior deficient phenotypes generated by uv irradiation are due to relative quantities of organizer. Our evidence demonstrates the existence of a continuum of body plan phenotypes based on this premise.« less

Splenic marginal zone lymphoma uncovered after a 10-year follow up as anemia of unknown cause.

PubMed

Koyama, Asumi; Shiotani, Chieko; Kurihara, Toshio; Mushino, Toshiki; Okamoto, Yukiharu; Tamaki, Tatsunori; Ozaki, Takashi; Ohshima, Kouichi; Tamura, Shinobu

2017-01-01

A 75-year-old man was referred to our hospital for evaluation of persistent anemia. Despite repeated diagnostic tests, including bone marrow aspiration, the cause of his anemia remained unknown. On each occasion, computed tomography had revealed neither swollen lymph nodes nor splenomegaly. After a 10-year follow-up period, he was admitted with general fatigue and had developed splenomegaly as well as the anemia. Bone marrow biopsy revealed increased abnormal lymphocytes with short villi that were positive for CD11c, CD19, CD20, and kappa chain, but not for CD5, CD10, CD23, or cyclin D1, according to flow cytometry. The bone marrow biopsy sample showed nodular proliferation of small to medium-sized abnormal lymphocytes. Based on these findings, the patient was diagnosed as having splenic marginal zone lymphoma, a rare indolent B-cell neoplasm. Although his splenomegaly diminished after eight cycles of weekly rituximab monotherapy, the anemia did not improve, and abnormal lymphocytes remained detectable in his bone marrow. The patient was then treated with bendamustine monotherapy for six cycles, after which the anemia resolved, and he has since been in good condition. Although rare, it is important to consider splenic marginal zone lymphoma during the differential diagnosis of patients with a long history of anemia of unknown cause.

Subcutaneous dissemination pattern in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma.

PubMed

Jonak, Constanze; Troch, Marlene; Kiesewetter, Barbara; Lukas, Julius; Müllauer, Leonhard; Jäger, Ulrich; Chott, Andreas; Raderer, Markus

2012-05-01

Mucosa-associated lymphoid tissue (MALT) lymphoma is among the most common forms of extranodal lymphomas, but little is known about subcutaneous involvement in patients with non-primary cutaneous marginal zone lymphomas. Patients with MALT lymphoma diagnosed and treated at our institution between 1999 and 2010 were analyzed for subcutaneous deposits from MALT lymphoma diagnosed in another organ. Histological, clinical and genetic findings were assessed. Among 216 patients with MALT lymphoma, 12 had subcutaneous deposits from MALT lymphoma (5.5%). In two patients, these lesions were present at diagnosis, while they constituted the site of relapse at an interval between 5 to 144 months in the remaining cases. Interestingly, nine of the 12 patients with subcutaneous deposits had originally been diagnosed with MALT lymphoma of the ocular adnexa (total number=51; 20%), and the other three had MALT lymphoma in the breast (total number=5; 60%). None of the patients with gastric (n=86), salivary gland (n=32) or pulmonary (n=19) MALT lymphomas had subcutaneous involvement during a median follow-up time of 87 months (range; 4 to 119 months). Our data show that subcutaneous MALT lymphoma involvement is a rare event in patients with prior non-cutaneous extranodal marginal zone lymphoma. However, it seems to be almost exclusively associated with MALT lymphoma of the ocular adnexa and the breast, suggesting as yet undefined interactions between potentially embryonically related organ systems.

Splenic marginal zone lymphoma: from genetics to management.

PubMed

Arcaini, Luca; Rossi, Davide; Paulli, Marco

2016-04-28

Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy involving the spleen, bone marrow, and frequently the blood. SMZL lymphomagenesis involves antigen and/or superantigen stimulation and molecular deregulation of genes (NOTCH2 and KLF2) involved in the physiological differentiation of spleen marginal zone B cells. Diagnosis requires either spleen histology or, alternatively, the documentation of a typical cell morphology and immunophenotype on blood cells coupled with the detection of intrasinusoidal infiltration by CD20(+) cells in the bone marrow. Among B-cell tumors, deletion of 7q and NOTCH2 mutations are almost specific lesions of SMZL, thus representing promising diagnostic biomarkers of this lymphoma. Although the majority of SMZLs show an indolent course with a median survival of approximately 10 years, nearly 30% of patients experience a poor outcome. No randomized trials are reported for SMZL, and few prospective trials are available. A watch-and-wait approach is advisable for asymptomatic patients. Treatment options for symptomatic patients ranges from splenectomy to rituximab alone or combined with chemotherapy. In some geographic areas, a subset of patients with SMZL associates with hepatitis C virus infection, prompting virus eradication as an effective lymphoma treatment. It would be worthwhile to explore deregulated cellular programs of SMZL as therapeutic targets in the future; improved clinical and biological prognostication will be essential for identifying patients who may benefit from novel approaches. © 2016 by The American Society of Hematology.

High-pressure/low-temperature metamorphism in the collision zone between the Chilenia and Cuyania microcontinents (western Precordillera, Argentina)

NASA Astrophysics Data System (ADS)

Boedo, F. L.; Willner, A. P.; Vujovich, G. I.; Massonne, H.-J.

2016-12-01

In central-western Argentina, an Early Paleozoic belt including mafic-ultramafic bodies, marine metasedimentary rocks and high-pressure rocks occur along the western margin of the Precordillera and in the Frontal Cordillera. First pressure-temperature estimates are presented here for low-grade rocks of the southern sector of this belt based on two metasedimentary and one metabasaltic sample from the Peñasco Formation. Peak metamorphic conditions resulted within the range of 345-395 °C and 7.0-9.3 kbar within the high-pressure greenschist facies. The corresponding low metamorphic gradient of 13 °C/km is comparable with subduction related geothermal gradients. Comparison between these results and data from other localities of the same collision zone (Guarguaraz and Colohuincul complexes) confirms a collision between Chilenia and the composite margin of western Gondwana and suggests a stronger crustal thickening in the south of the belt, causing exhumation of more deeply buried sequences. During the Early Paleozoic a long-lived marine sedimentation coupled with the intrusion of MORB-like basalts occurred along a stable margin before the collision event. This contrasts with the almost contemporaneous sedimentation registered during accretion in accretionary prism settings and additionally proves the development of a collision zone along western Precordillera and the eastern Frontal Cordillera as well as the existence of Chilenia as a separate microcontinent.

Primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse epibulbar extension and focal infiltration of the optic nerve and meninges, clinically presented as uveitis masquerade syndrome: a case report.

PubMed

Rasić, D M; Stanković, Z; Terzić, T; Kovacević, D; Koturović, Z; Marković, V

2010-09-01

To report a clinical, histopathological and immunohistochemical findings in a case of primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse extraocular episcleral extension and focal infiltration of the optic nerve and meninges, clinically presented as longstanding uveitis masquerade syndrome. Interventional case reports with histopathological correlation. We describe a 80-year-old male patient with a 3-year history of chronic recurrent hypertensive (pan) uveitis associated with ocular pain, unresponsive to topical and systemic anti-inflammatory, immunosuppressive, antibiotic/antiviral and antiglaucomatous therapy. Because the eye was not salvageable with conservative treatment, enucleation of blind and painful eye was performed. Findings from histopathological and immunohistochemistry examination of the enucleated eye showed an extranodal marginal zone lymphoma of the uveal tract with massive epibulbar extension and optic nerve and meningeal penetration. During almost 3 years of clinical course and 6 months after the enucleation, there were no systemic manifestations of lymphoma, and patient has not required subsequent treatment. Primary lymphoproliferative lesions of the uvea, comprising the iris, ciliary body and choroid are very rare, associated with epibulbar extension extremely and with optic nerve and menigeal penetration exceptionally. Despite its rarity, primary lymphoma of the uvea should be included in the differential diagnosis particularly in older patients with longstanding recurrent uveitis.

A spatial classification and database for management, research, and policy making: The Great Lakes aquatic habitat framework

USGS Publications Warehouse

Wang, Lizhu; Riseng, Catherine M.; Mason, Lacey; Werhrly, Kevin; Rutherford, Edward; McKenna, James E.; Castiglione, Chris; Johnson, Lucinda B.; Infante, Dana M.; Sowa, Scott P.; Robertson, Mike; Schaeffer, Jeff; Khoury, Mary; Gaiot, John; Hollenhurst, Tom; Brooks, Colin N.; Coscarelli, Mark

2015-01-01

Managing the world's largest and most complex freshwater ecosystem, the Laurentian Great Lakes, requires a spatially hierarchical basin-wide database of ecological and socioeconomic information that is comparable across the region. To meet such a need, we developed a spatial classification framework and database — Great Lakes Aquatic Habitat Framework (GLAHF). GLAHF consists of catchments, coastal terrestrial, coastal margin, nearshore, and offshore zones that encompass the entire Great Lakes Basin. The catchments captured in the database as river pour points or coastline segments are attributed with data known to influence physicochemical and biological characteristics of the lakes from the catchments. The coastal terrestrial zone consists of 30-m grid cells attributed with data from the terrestrial region that has direct connection with the lakes. The coastal margin and nearshore zones consist of 30-m grid cells attributed with data describing the coastline conditions, coastal human disturbances, and moderately to highly variable physicochemical and biological characteristics. The offshore zone consists of 1.8-km grid cells attributed with data that are spatially less variable compared with the other aquatic zones. These spatial classification zones and their associated data are nested within lake sub-basins and political boundaries and allow the synthesis of information from grid cells to classification zones, within and among political boundaries, lake sub-basins, Great Lakes, or within the entire Great Lakes Basin. This spatially structured database could help the development of basin-wide management plans, prioritize locations for funding and specific management actions, track protection and restoration progress, and conduct research for science-based decision making.

Early development of the circumferential axonal pathway in mouse and chick spinal cord.

PubMed

Holley, J A

1982-03-10

The early development of the circumferential axonal pathway in the brachial and lumbar spinal cord of mouse and chick embryos was studied by scanning and transmission electron microscopy. The cellular processes which comprise this pathway grow in the transverse plane and along the lateral margin of the marginal zone (i.e., circumferentially oriented), as typified by the early embryonic commissural axons. The first formative event observed was in the ventrolateral margin of the primitive spinal cord ventricular zone. Cellular processes were found near the external limiting membrane that appeared to grow a variable distance either dorsally or ventrally. Later in development, presumptive motor column neurons migrated into the ventrolateral region, distal to these early circumferentially oriented processes. Concurrently, other circumferentially oriented perikarya and processes appeared along the dorsolateral margin. Due to their aligned sites of origin and parallel growth, the circumferential processes formed a more or less continuous line or pathway, which in about 10% of the scanned specimens could be followed along the entire lateral margin of the embryonic spinal cord. Several specimens later in development had two sets of aligned circumferential processes in the ventral region. Large numbers of circumferential axons were then found to follow the preformed pathway by fasciculation, after the primitive motor column had become established. Since the earliest circumferential processes appeared to differentiate into axons and were found nearly 24 hours prior to growth of most circumferential axons, their role in guidance as pioneering axons was suggested.

Interaction of the subduction process and forearc tectonics: An example from the active N - Chilean margin

NASA Astrophysics Data System (ADS)

Victor, P.; Sobiesiak, M.

2005-12-01

Convergent plate boundaries at continental margins belong to the tectonically most active areas on earth and are endangered by devastating earthquakes and tsunamis. The north Chilean margin is a high strain continental margin driven by fast plate convergence rate. The greatest amount of strain is accommodated along the subduction interface. Nevertheless there is extensive crustal deformation obvious by surface ruptures along reactivated segments of large fault systems and vertical surface motions reflecting the interaction between subducting and overriding plates. The historical seismicity record indicates that great earthquakes affect the Chilean Forearc with recurrence intervals of about 112+/- 21 y . The last great event in northern Chile occurred in 1995 near Antofagasta. The Mw= 8.0 event ruptured the subduction interface 180 km along strike with an average slip of about 5m in the depth interval between 10-50 km. From careful evaluation of the aftershock sequence by examining the different catagories of aftershock focal mechanisms we can define three segments of the seismogenic zone affected by the Antofagasta main shock. The non-ruptured northern segment beneath Mejillones Peninsula is seperated by a broad transition zone from the central segment which hosts the earthquakes' rupture plane. The southern fault plane boundary is identified by linear alignment of all apparent aftershock mechanisms. Along this southern boundary the strike slip mechanisms are exclusively left lateral whereas the strike slip mechanisms along the northern transition zone are right lateral. The orientations of summed moment tensors calculated from aftershock fault plane solutions on the northern segment and in the northern transition zone differ from the orientations exhibited by moment tensors on the central segment. This might indicate a rotational component in the coseismic movement of the ruptured segment relative to the non-ruptured segment. The observed segmentation of the downgoing plate correlates well with changes in the coseismic surface displacement field and coseismic rotations derived from GPS data (Allmendinger et al. in press). We can localize a transition zone at Mejillones peninsula (23,5°S) striking approximately N 80°E dominated by clockwise vertical axis rotations also marked by rotations of the summed moment tensors on the downgoing plate. The calculated strain tensor for this transition zone does not correspond with long term surface deformation, implying that coseismic as well as early postseismic effects on the subduction interface do not contribute to long term deformation of crustal fault zones. The Antofagasta earthquake took place just south of the large 1877 gap which extends from southern Peru to Mejillones Peninsula, being the surface expression of a barrier seperating the Antofagasta fault plane from the expected future fault plane. From our studies of the Antofagasta subduction zone and the surface displacement field we hope to find evidences for interface-crust-surface interactions which can be extrapolated also to the 1877 gap.

Structure of the North American Atlantic Continental Margin

USGS Publications Warehouse

Schlee, J.S.; Klitgord, K.K.

1986-01-01

Off E N America, where the structure of the continental margin is essentially constructional, seismic profiles have approximated geologic cross sections up to 10-15km below the sea floor and revealed major structural and stratigraphic features that have regional hydrocarbon potential. These features include a) a block-faulted basement hinge zone; b) a deep, broad, rifted basement filled with clastic sediment and salt; and c) a buried paleoshelf-edge complex that has many forms. The mapping of seismostratigraphic units over the continental shelf, slope, and rise has shown that the margin's developmental state included infilling of a rifted margin, buildup of a carbonate platform, and construction of an onlapping continental-rise wedge that was accompanied by erosion of the slope. -from Authors

The northern Lesser Antilles oblique subduction zone: new insight about the upper plate deformation, 3D slab geometry and interplate coupling.

NASA Astrophysics Data System (ADS)

Marcaillou, B.; Laurencin, M.; Graindorge, D.; Klingelhoefer, F.

2017-12-01

In subduction zones, the 3D geometry of the plate interface is thought to be a key parameter for the control of margin tectonic deformation, interplate coupling and seismogenic behavior. In the northern Caribbean subduction, precisely between the Virgin Islands and northern Lesser Antilles, these subjects remain controversial or unresolved. During the ANTITHESIS cruises (2013-2016), we recorded wide-angle seismic, multichannel reflection seismic and bathymetric data along this zone in order to constrain the nature and the geometry of the subducting and upper plate. This experiment results in the following conclusions: 1) The Anegada Passage is a 450-km long structure accross the forearc related to the extension due to the collision with the Bahamas platform. 2) More recently, the tectonic partitioning due to the plate convergence obliquity re-activated the Anegada Passage in the left-lateral strike-slip system. The partitioning also generated the left-lateral strike-slip Bunce Fault, separating the accretionary prism from the forearc. 3) Offshore of the Virgin Islands margin, the subducting plate shows normal faults parallel to the ancient spreading center that correspond to the primary fabric of the oceanic crust. In contrast, offshore of Barbuda Island, the oceanic crust fabric is unresolved (fracture zone?, exhumed mantle? ). 4) In the direction of the plate convergence vector, the slab deepening angle decreases northward. It results in a shallower slab beneath the Virgin Islands Platform compared to the St Martin-Barbuda forearc. In the past, the collision of the Bahamas platform likely changed the geodynamic settings of the northeastern corner of the Caribbean subduction zone and we present a revised geodynamic history of the region. Currently, various features are likely to control the 3D geometry of the slab: the margin convexity, the convergence obliquity, the heterogeneity of the primary fabric of the oceanic crust and the Bahamas docking. We suggest that the slab deepening angle lower beneath the Virgin Islands segment than beneath the St Martin-Barbuda segment possibly generates a northward increasing interplate coupling. As a result, it possibly favors an increase in the seismic activity and the tectonic partitioning beneath the Virgin Islands margin contrary to the St Martin-Barbuda segment.

A coupled ice-ocean model of ice breakup and banding in the marginal ice zone

NASA Technical Reports Server (NTRS)

Smedstad, O. M.; Roed, L. P.

1985-01-01

A coupled ice-ocean numerical model for the marginal ice zone is considered. The model consists of a nonlinear sea ice model and a two-layer (reduced gravity) ocean model. The dependence of the upwelling response on wind stress direction is discussed. The results confirm earlier analytical work. It is shown that there exist directions for which there is no upwelling, while other directions give maximum upwelling in terms of the volume of uplifted water. The ice and ocean is coupled directly through the stress at the ice-ocean interface. An interesting consequence of the coupling is found in cases when the ice edge is almost stationary. In these cases the ice tends to break up a few tenths of kilometers inside of the ice edge.

Active/passive microwave sensor comparison of MIZ-ice concentration estimates. [Marginal Ice Zone (MIZ)

NASA Technical Reports Server (NTRS)

Burns, B. A.; Cavalieri, D. J.; Keller, M. R.

1986-01-01

Active and passive microwave data collected during the 1984 summer Marginal Ice Zone Experiment in the Fram Strait (MIZEX 84) are used to compare ice concentration estimates derived from synthetic aperture radar (SAR) data to those obtained from passive microwave imagery at several frequencies. The comparison is carried out to evaluate SAR performance against the more established passive microwave technique, and to investigate discrepancies in terms of how ice surface conditions, imaging geometry, and choice of algorithm parameters affect each sensor. Active and passive estimates of ice concentration agree on average to within 12%. Estimates from the multichannel passive microwave data show best agreement with the SAR estimates because the multichannel algorithm effectively accounts for the range in ice floe brightness temperatures observed in the MIZ.

Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer

ClinicalTrials.gov

2017-04-10

Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hematopoietic/Lymphoid Cancer; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Myelodysplastic Syndromes; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage II Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Childhood Hodgkin Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia

Local response of a glacier to annual filling and drainage of an ice-marginal lake

USGS Publications Warehouse

Walder, J.S.; Trabant, D.C.; Cunico, M.; Fountain, A.G.; Anderson, S.P.; Anderson, R. Scott; Malm, A.

2006-01-01

Ice-marginal Hidden Creek Lake, Alaska, USA, outbursts annually over the course of 2-3 days. As the lake fills, survey targets on the surface of the 'ice dam' (the glacier adjacent to the lake) move obliquely to the ice margin and rise substantially. As the lake drains, ice motion speeds up, becomes nearly perpendicular to the face of the ice dam, and the ice surface drops. Vertical movement of the ice dam probably reflects growth and decay of a wedge of water beneath the ice dam, in line with established ideas about jo??kulhlaup mechanics. However, the distribution of vertical ice movement, with a narrow (50-100 m wide) zone where the uplift rate decreases by 90%, cannot be explained by invoking flexure of the ice dam in a fashion analogous to tidal flexure of a floating glacier tongue or ice shelf. Rather, the zone of large uplift-rate gradient is a fault zone: ice-dam deformation is dominated by movement along high-angle faults that cut the ice dam through its entire thickness, with the sense of fault slip reversing as the lake drains. Survey targets spanning the zone of steep uplift gradient move relative to one another in a nearly reversible fashion as the lake fills and drains. The horizontal strain rate also undergoes a reversal across this zone, being compressional as the lake fills, but extensional as the lake drains. Frictional resistance to fault-block motion probably accounts for the fact that lake level falls measurably before the onset of accelerated horizontal motion and vertical downdrop. As the overall fault pattern is the same from year to year, even though ice is lost by calving, the faults must be regularly regenerated, probably by linkage of surface and bottom crevasses as ice is advected toward the lake basin.

Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma

ClinicalTrials.gov

2018-04-27

Blastic Plasmacytoid Dendritic Cell Neoplasm; Hepatosplenic T-Cell Lymphoma; HTLV-1 Infection; NK-Cell Lymphoma, Unclassifiable; Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Negative; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Anaplastic Large Cell Lymphoma; Recurrent Angioimmunoblastic T-cell Lymphoma; Recurrent Enteropathy-Associated T-Cell Lymphoma; Recurrent Mycosis Fungoides; Refractory Adult T-Cell Leukemia/Lymphoma; Refractory Anaplastic Large Cell Lymphoma; Refractory Angioimmunoblastic T-cell Lymphoma; Refractory Enteropathy-Associated T-Cell Lymphoma; Refractory Mycosis Fungoides; Refractory Nasal Type Extranodal NK/T-Cell Lymphoma; Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified

Opening of the Central Atlantic Ocean: Implications for Geometric Rifting and Asymmetric Initial Seafloor Spreading after Continental Breakup

NASA Astrophysics Data System (ADS)

Klingelhoefer, F.; Biari, Y.; Sahabi, M.; Funck, T.; Benabdellouahed, M.; Schnabel, M.; Reichert, C. J.; Gutscher, M. A.; Bronner, A.; Austin, J. A., Jr.

2017-12-01

The structure of conjugate passive margins provides information about rifting styles, the initial phases of the opening of an ocean and the formation of its associated sedimentary basins. The study of the deep structure of conjugate passive continental margins combined with precise plate kinematic reconstructions can provide constraints on the mechanisms of rifting and formation of initial oceanic crust. In this study the Central Atlantic conjugate margins are compared, based on compilation of wide-angle seismic profiles from the NW-Africa Nova Scotian and US passive margins. Plate cinematic reconstructions were used to place the profiles in the position at opening and at the M25 magnetic anomaly. The patterns of volcanism, crustal thickness, geometry, and seismic velocities in the transition zone. suggest symmetric rifting followed by asymmetric oceanic crustal accretion. Conjugate profiles in the southern Central Atlantic image differences in the continental crustal thickness. While profiles on the eastern US margin are characterized by thick layers of magmatic underplating, no such underplate was imaged along the NW-African continental margin. It has been proposed that these volcanic products form part of the CAMP (Central Atlantic Magmatic Province). In the north, two wide-angle seismic profiles acquired in exactly conjugate positions show that the crustal geometry of the unthinned continental crust and the necking zone are nearly symmetric. A region including seismic velocities too high to be explained by either continental or oceanic crust is imaged along the Nova Scotia margin off Eastern Canada, corresponding on the African side to an oceanic crust with slightly elevated velocities. These might result from asymmetric spreading creating seafloor by faulting the existing lithosphere on the Canadian side and the emplacement of magmatic oceanic crust including pockets of serpentinite on the Moroccan margin. A slightly elevated crustal thickness along the African margin can be explained by the influence of the Canary hotspot between 60 and 30 Ma in the study region. After isochron M25, a large-scale plate reorganization may then have led to an increase in spreading velocity and the production of a more typical but thin magmatic crust on both sides.

What are the Geophysical Fingerprints of hyper-extended Crustal Domains ?

NASA Astrophysics Data System (ADS)

Stanton, N.; Manatschal, G.; Maia, M.; Viana, A.; Tugend, J.; Autin, J.

2012-04-01

The Iberian margin is a well-studied region and presently the best tectonic setting for understanding the dynamic process of margin's formation and evolution. The world largest available dataset enabled to properly constrain the crustal structure and opened new paradigms for passive margins studies. Nevertheless, there are numerous remaining questions, as for example what is the spatial extent of continental inheritance along the margin and what is the role of fluids (serpentinization/magmatism) during margin's formation/deformation? The observation of a hyper-extended crustal domain, now also identified in other margins reveals the highly diverse nature of the crust along rifted margins. What are its physical properties and how do they change laterally? The aim of this study is to explore the physical signature of the serpentinized crust, which composes this hyper-extended domain, to identify the limits of the system and discuss its nature and importance. To investigate the lateral variation of crustal types we use integrated gravity, magnetic, seismic and available geological/well data. Transformations on the potential field data enable us to enhance the horizontal and vertical variations of the crust, and future forward modeling will provide a geological correlation for Iberia. The preliminary results showed that the transitional crust can be subdivided into two zones, regarding their different geophysical signatures: from the necking zone, the continent ward transitional crust displays decreasing gravity anomaly, low horizontal gradient and smooth magnetic anomalies; towards offshore (to the west of the J anomaly) the transitional crust is characterized by a semi-cyclic magnetic anomaly pattern, with increasing gravity, showing a stronger horizontal gradient and rough bathymetry. We associate this transitional domain with an embryonic oceanic type crust. Comparisons with other margins along the North Atlantic, despite the great spatial variation, reveals preliminarily that the hyper-extended crust at the non-volcanic Iberia Margin displays intrinsic characteristics distinct from the more volcanic transitional domains to the north. The physical properties of the different crustal types will be further modeled to properly constrain their characteristics. The final results shall enable us to identify the lateral transition between the different continental-transitional hydrated-oceanic crustal types and potentially would allow us to identify similar domains worldwide.

Multidisciplinary approach for the characterization of a new Late Cretaceous continental arc in the Central Pontides (Northern Turkey)

NASA Astrophysics Data System (ADS)

Ellero, Alessandro; Ottria, Giuseppe; Sayit, Kaan; Catanzariti, Rita; Frassi, Chiara; Cemal Göncüoǧlu, M.; Marroni, Michele; Pandolfi, Luca

2016-04-01

In the Central Pontides (Northern Turkey), south of Tosya, a tectonic unit consisting of not-metamorphic volcanic rocks and overlying sedimentary succession is exposed inside a fault-bounded elongated block. It is restrained within a wide shear zone, where the Intra-Pontide suture zone, the Sakarya terrane and the Izmir-Ankara-Erzincan suture zone are juxtaposed as result of strike-slip activity of the North Anatolian shear zone. The volcanic rocks are mainly basalts and basaltic andesites (with their pyroclastic equivalents) associated with a volcaniclastic formation made up of breccias and sandstones that are stratigraphically overlain by a Marly-calcareous turbidite formation. The calcareous nannofossil biostratigraphy points to a late Santonian-middle Campanian age (CC17-CC21 Zones) for the sedimentary succession. The geochemistry of the volcanic rocks reveals an active continental margin setting as evidenced by the enrichment in Th and LREE over HFSE, and the Nb-enriched nature of these lavas relative to N-MORB. As highlighted by the performed arenite petrography, the occurrence of continent-derived clastics in the sedimentary succession supports the hypothesis of a continental arc-derived volcanic succession. Alternative geodynamic reconstructions are proposed, where this tectonic unit could represent a slice derived from the northern continental margin of the Intra- Pontide or Izmir-Ankara-Erzincan oceanic basins.

Continuous Spectrum of Crustal Structures and Spreading Processes from Volcanic Rifted Margins to Mid-Ocean Ridges

NASA Astrophysics Data System (ADS)

Karson, J. A.

2016-12-01

Structures generated by seafloor spreading in oceanic crust (and ophiolites) and thick oceanic crust of Iceland show a continuous spectrum of features that formed by similar mechanisms but at different scales. A high magma budget near the Iceland hotspot generates thick (40-25 km) mafic crust in a plate boundary zone about 50 km wide. The upper crust ( 10 km thick) is constructed by the subaxial subsidence and thickening of lavas fed by dense dike swarms over a hot, weak lower crust to produce structures analogous to seaward-dipping reflectors of volcanic rifted margins. Segmented rift zones propagate away from the hotspot creating migrating transform fault zones, microplate-like crustal blocks and rift-parallel strike-slip faults. These structures are decoupled from the underlying lower crustal gabbroic rocks that thin by along-axis flow that reduces the overall crustal thickness and smooths-out local crustal thickness variations. Spreading on mid-ocean ridges with high magma budgets have much thinner crust (10-5 km) generated at a much narrower (few km) plate boundary zone. Subaxial subsidence accommodates the thickening of the upper crust of inward-dipping lavas and outward-dipping dikes about 1-2 km thick over a hot weak lower crust. Along-axis (high-temperature ductile and magmatic) flow of lower crustal material may help account for the relatively uniform seismic thickness of oceanic crust worldwide. Spreading along even slow-spreading mid-ocean ridges near hotspots (e.g., the Reykjanes Ridge) probably have similar features that are transitional between these extremes. In all of these settings, upper crustal and lower crustal structures are decoupled near the plate boundary but eventually welded together as the crust ages and cools. Similar processes are likely to occur along volcanic rifted margins as spreading begins.

UAV Deployed Sensor System for Arctic Ocean Remote Sensing

NASA Astrophysics Data System (ADS)

Palo, S. E.; Lawrence, D.; Weibel, D.; LoDolce, G.; Krist, S.; Crocker, I.; Maslanik, J. A.

2012-12-01

The Marginal Ice Zone Observations and Processes Experiment (MIZOPEX), is an Arctic field project scheduled for summer 2013. The goals of the project are to understand how warming of the marginal ice zone affects sea ice melt and if this warming has been over or underestimated by satellite measurements. To achieve these goals calibrated physical measurements, both remote and in-situ, of the marginal ice zone over scales of square kilometers with a resolution of square meters is required. This will be accomplished with a suite of unmanned aerial vehicles (UAVs) equipped with both remote sensing and in-situ instruments, air deployed microbuoys, and ship deployed buoys. In this talk we will present details about the air-deployed micro-buoy (ADMB) and self-deployed surface-sonde (SDSS) components of the MIZOPEX project, developed at the University of Colorado. These systems were designed to explore the potential of low-cost, on-demand access to high-latitude areas of important scientific interest. Both the ADMB and SDSS share a common measurement suite with the capability to measure water temperature at three distinct depths and provide position information via GPS. The ADMBs are dropped from the InSitu ScanEagle UAV and expected to operate and log ocean temperatures for 14 days. The SDSS are micro UAVs that are designed to fly one-way to a region of interest and land at specified coordinates, thereafter becoming a surface sensor similar to the ADMB. A ScanEagle will periodically return to the deployment zone to gather ADMB/SDSS data via low power radio links. Design decisions based upon operational constraints and the current status of the ADMB and SDSS will be presented.

Influence of increasing convergence obliquity and shallow slab geometry onto tectonic deformation and seismogenic behavior along the Northern Lesser Antilles zone

NASA Astrophysics Data System (ADS)

Laurencin, M.; Graindorge, D.; Klingelhoefer, F.; Marcaillou, B.; Evain, M.

2018-06-01

In subduction zones, the 3D geometry of the plate interface is one of the key parameters that controls margin tectonic deformation, interplate coupling and seismogenic behavior. The North American plate subducts beneath the convex Northern Lesser Antilles margin. This convergent plate boundary, with a northward increasing convergence obliquity, turns into a sinistral strike-slip limit at the northwestern end of the system. This geodynamic context suggests a complex slab geometry, which has never been imaged before. Moreover, the seismic activity and particularly the number of events with thrust focal mechanism compatible with subduction earthquakes, increases northward from the Barbuda-Anguilla segment to the Anguilla-Virgin Islands segment. One of the major questions in this area is thus to analyze the influence of the increasing convergence obliquity and the slab geometry onto tectonic deformation and seismogenic behavior of the subduction zone. Based on wide-angle and multichannel reflection seismic data acquired during the Antithesis cruises (2013-2016), we decipher the deep structure of this subduction zone. Velocity models derived from wide-angle data acquired across the Anegada Passage are consistent with the presence of a crust of oceanic affinity thickened by hotspot magmatism and probably affected by the Upper Cretaceous-Eocene arc magmatism forming the 'Great Arc of the Caribbean'. The slab is shallower beneath the Anguilla-Virgin Islands margin segment than beneath the Anguilla-Barbuda segment which is likely to be directly related to the convex geometry of the upper plate. This shallower slab is located under the forearc where earthquakes and partitioning deformations increase locally. Thus, the shallowing slab might result in local greater interplate coupling and basal friction favoring seismic activity and tectonic partitioning beneath the Virgin Islands platform.

Formation of Cretaceous Cordilleran and post-orogenic granites and their microgranular enclaves from the Dalat zone, southern Vietnam: Tectonic implications for the evolution of Southeast Asia

NASA Astrophysics Data System (ADS)

Shellnutt, J. Gregory; Lan, Ching-Ying; Van Long, Trinh; Usuki, Tadashi; Yang, Huai-Jen; Mertzman, Stanley A.; Iizuka, Yoshi; Chung, Sun-Lin; Wang, Kuo-Lung; Hsu, Wen-Yu

2013-12-01

Cordilleran-type batholiths are useful in understanding the duration, cyclicity and tectonic evolution of continental margins. The Dalat zone of southern Vietnam preserves evidence of Late Mesozoic convergent zone magmatism superimposed on Precambrian rocks of the Indochina Block. The Dinhquan, Deoca and Ankroet plutons and their enclaves indicate that the Dalat zone transitioned from an active continental margin producing Cordilleran-type batholiths to highly extended crust producing within-plate plutons. The Deoca and Dinhquan plutons are compositionally similar to Cordilleran I-type granitic rocks and yield mean zircon U/Pb ages between 118 ± 1.4 Ma and 115 ± 1.2 Ma. Their Sr-Nd whole rock isotopes (ISr = 0.7044 to 0.7062; εNd(T) = - 2.4 to + 0.2) and zircon Hf isotopes (εHf(T) = + 8.2 ± 1.2 and + 6.4 ± 0.9) indicate that they were derived by mixing between a mantle component and an enriched component (i.e. GLOSS). The Ankroet pluton is chemically similar to post-orogenic/within-plate granitic rocks and has a zircon U/Pb age of 87 ± 1.6 Ma. Geobarometric calculations indicate that amphibole within the Ankroet pluton crystallized at a depth of ~ 6 kbar which is consistent with the somewhat more depleted Sr-Nd isotope (ISr = 0.7017 to 0.7111; εNd(T) = - 2.8 to + 0.6) and variable εHf(T) compositions suggesting a stronger influence of crustal material in the parental magma. The compositional change of the Dalat zone granitic rocks during the middle to late Cretaceous indicates that the tectonic regime evolved from a continental arc environment to one of post-orogenic extension. The appearance of sporadic post-90 Ma magmatism in the Dalat zone and along the eastern margin of Eurasian indicates that there was no subsequent orogenic event and the region was likely one of highly extended crust that facilitated the opening of the South China Sea during the latter half of the Cenozoic.

Modeling ocean wave propagation under sea ice covers

NASA Astrophysics Data System (ADS)

Zhao, Xin; Shen, Hayley H.; Cheng, Sukun

2015-02-01

Operational ocean wave models need to work globally, yet current ocean wave models can only treat ice-covered regions crudely. The purpose of this paper is to provide a brief overview of ice effects on wave propagation and different research methodology used in studying these effects. Based on its proximity to land or sea, sea ice can be classified as: landfast ice zone, shear zone, and the marginal ice zone. All ice covers attenuate wave energy. Only long swells can penetrate deep into an ice cover. Being closest to open water, wave propagation in the marginal ice zone is the most complex to model. The physical appearance of sea ice in the marginal ice zone varies. Grease ice, pancake ice, brash ice, floe aggregates, and continuous ice sheet may be found in this zone at different times and locations. These types of ice are formed under different thermal-mechanical forcing. There are three classic models that describe wave propagation through an idealized ice cover: mass loading, thin elastic plate, and viscous layer models. From physical arguments we may conjecture that mass loading model is suitable for disjoint aggregates of ice floes much smaller than the wavelength, thin elastic plate model is suitable for a continuous ice sheet, and the viscous layer model is suitable for grease ice. For different sea ice types we may need different wave ice interaction models. A recently proposed viscoelastic model is able to synthesize all three classic models into one. Under suitable limiting conditions it converges to the three previous models. The complete theoretical framework for evaluating wave propagation through various ice covers need to be implemented in the operational ocean wave models. In this review, we introduce the sea ice types, previous wave ice interaction models, wave attenuation mechanisms, the methods to calculate wave reflection and transmission between different ice covers, and the effect of ice floe breaking on shaping the sea ice morphology. Laboratory experiments, field measurements and numerical simulations supporting the fundamental research in wave-ice interaction models are discussed. We conclude with some outlook of future research needs in this field.

Evaluating the Potential of Marginal Land for Cellulosic Feedstock Production and Carbon Sequestration in the United States

DOE PAGES

Emery, Isaac; Mueller, Steffen; Qin, Zhangcai; ...

2016-12-01

Land availability for growing feedstocks at scale is a crucial concern for the bioenergy industry. Feedstock production on land not well-suited to growing conventional crops, or marginal land, is often promoted as ideal, although there is a poor understanding of the qualities, quantity, and distribution of marginal lands in the United States. In this paper, we examine the spatial distribution of land complying with several key marginal land definitions at the United States county, agro-ecological zone, and national scales, and compare the ability of both marginal land and land cover data sets to identify regions for feedstock production. We concludemore » that very few land parcels comply with multiple definitions of marginal land. Furthermore, to examine possible carbon-flow implications of feedstock production on land that could be considered marginal per multiple definitions, we model soil carbon changes upon transitions from marginal cropland, grassland, and cropland–pastureland to switchgrass production for three marginal land-rich counties. Finally, our findings suggest that total soil organic carbon changes per county are small, and generally positive, and can influence life-cycle greenhouse gas emissions of switchgrass ethanol.« less

Evaluating the Potential of Marginal Land for Cellulosic Feedstock Production and Carbon Sequestration in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Emery, Isaac; Mueller, Steffen; Qin, Zhangcai

Land availability for growing feedstocks at scale is a crucial concern for the bioenergy industry. Feedstock production on land not well-suited to growing conventional crops, or marginal land, is often promoted as ideal, although there is a poor understanding of the qualities, quantity, and distribution of marginal lands in the United States. In this paper, we examine the spatial distribution of land complying with several key marginal land definitions at the United States county, agro-ecological zone, and national scales, and compare the ability of both marginal land and land cover data sets to identify regions for feedstock production. We concludemore » that very few land parcels comply with multiple definitions of marginal land. Furthermore, to examine possible carbon-flow implications of feedstock production on land that could be considered marginal per multiple definitions, we model soil carbon changes upon transitions from marginal cropland, grassland, and cropland–pastureland to switchgrass production for three marginal land-rich counties. Finally, our findings suggest that total soil organic carbon changes per county are small, and generally positive, and can influence life-cycle greenhouse gas emissions of switchgrass ethanol.« less

Shear zones bounding the central zone of the Limpopo Mobile Belt, southern Africa

NASA Astrophysics Data System (ADS)

McCouri, Stephen; Vearncombe, Julian R.

Contrary to previously suggested north-directed thrust emplacement of the central zone of the Limpopo mobile belt, we present evidence indicating west-directed emplacement. The central zone differs from the marginal zones in rock types, structural style and isotopic signature and is an allochthonous thrust sheet. It is bounded in the north by the dextral Tuli-Sabi shear zone and in the south by the sinistral Palala shear zone which are crustal-scale lateral ramps. Published gravity data suggest that the lateral ramps are linked at depth and they probably link at the surface, in a convex westward frontal ramp, in the vicinity of longitude 26°30'E in eastern Botswana. Two phases of movement, the first between 2.7 and 2.6 Ga and the second between 2.0 and 1.8 Ga. occurred on both the Tuli-Sabi and the Palala shear zones.

Differentiating zones at periodontal ligament-bone and periodontal ligament-cementum entheses.

PubMed

Lee, J-H; Pryce, B A; Schweitzer, R; Ryder, M I; Ho, S P

2015-12-01

The structural and functional integrity of bone-periodontal ligament (PDL)-cementum complex stems from the load-bearing attachment sites (entheses) between soft (PDL) and hard (bone, cementum) tissues. These attachment sites are responsible for the maintenance of a bone-PDL-cementum complex biomechanical function. The objective was to investigate changes in spatiotemporal expression of key biomolecules in developing and functionally active entheses. Multilabeling technique was performed on hemimandibles of 3 wk and 3 mo-old scleraxis-GFP transgenic mice for CD146, CD31, NG2, osterix and bone sialoprotein. Regions of dominant stretch within the PDL were evaluated by identifying directionality of collagen fibrils, PDL fibroblasts and PDL cell cytoskeleton. CD146+ cells adjacent to CD31+ vasculature were identified at PDL-bone enthesis. NG2+ cells were located at coronal bone-PDL and apical cementum-PDL entheses in the 3-wk-old group, but at 3 mo, NG2 was positive at the entheses of the apical region and alveolar crest. NG2 and osterix were colocalized at the osteoid and cementoid regions of the PDL-bone and PDL-cementum entheses. Bone sialoprotein was prominent at the apical region of 3-wk-old mice. The directionality of collagen fibers, fibroblasts and their cytoskeleton overlapped, except in the apical region of 3 wk. Colocalization of biomolecules at zones of the PDL adjacent to attachment sites may be essential for the formation of precementum and osteoid interfaces at a load-bearing bone-PDL-tooth fibrous joint. Biophysical cues resulting from development and function can regulate recruitment and differentiation of stem cells potentially from a vascular origin toward osteo- and cemento-blastic lineages at the PDL-bone and PDL-cementum entheses. Investigating the coupled effect of biophysical and biochemical stimuli leading to cell differentiation at the functional attachment sites is critical for developing regeneration strategies to enable functional reconstruction of the periodontal complex. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The Tell-Rif belt in the geodynamic frame of the West Mediterranean

NASA Astrophysics Data System (ADS)

Leprêtre, Rémi; Frizon de Lamotte, Dominique; Combier, Violaine; Gorini, Christian; Eschard, Remi

2017-04-01

The Tell-Rif (Tell in Algeria and Tunisia; Rif in Morocco) or Maghrebides is the orogenic system fringing the West Mediterranean basins to the south. This system comprises 3 major tectonic-paleogeographic zones from north to south: (1) the internal zones (AlKaPeCa for Alboran, Kabylies, Peloritan, Calabria) originated from the former northern European margin of the Maghrebian Tethys (MT); (2) the "flyschs zone" regarded as the former sedimentary cover of the MT and (3) the external zones, the former southern African passive margin of the MT. In the geodynamic frame of the West Mediterranean basins formation, the Tell-Rif is interpreted as the direct result of the progressive closure of the MT until the collision between AlKaPeCa and Africa at 17 Ma and the propagation of the deformation within Africa. Such a scenario gives a consistent explanation for the off-shore geodynamics and is now shared by almost all the authors. Nevertheless, all the geodynamic models do not integrate recent developments regarding the geology the Tell-Rif. In particular, the following points must be integrated in any models: (1) The importance of pre-Late Oligocene (pre-30 Ma) contractional events not only in the Atlas System, where they are well established, but also in the Tell-Rif system, where their effects are often ignored or minimized; (2) The existence of MP-BT metamorphic rocks associated with fragments of ophiolites in the Eastern External Rif and likely in the Western External Tell suggesting that the southern Maghrebian Tethys margin is more complicated than what could be expected for a single linear oceanic domain; (3) The presence over the Rif and western Tell of wide Miocene basins developed along with the ones of the West Mediterranean Basins. Among these basins, the Cheliff Basin occupies a large part of the western Tell in Algeria. These elements must be taken into account for a reassessment of the complex relationships between the West Mediterranean Basins and the surrounding mountain belts. Integration of these major issues allows us to re-evaluate the configuration of the African margin before the inversion and to propose a kinematic scenario for the Tell-Rif.

Characterization of a stratigraphically constrained gas hydrate system along the western continental margin of Svalbard from ocean bottom seismometer data

NASA Astrophysics Data System (ADS)

Chabert, Anne; Minshull, Tim A.; Westbrook, Graham K.; Berndt, Christian; Thatcher, Kate E.; Sarkar, Sudipta

2011-12-01

The ongoing warming of bottom water in the Arctic region is anticipated to destabilize some of the gas hydrate present in shallow seafloor sediment, potentially causing the release of methane from dissociating hydrate into the ocean and the atmosphere. Ocean-bottom seismometer (OBS) experiments were conducted along the continental margin of western Svalbard to quantify the amount of methane present as hydrate or gas beneath the seabed. P- and S-wave velocities were modeled for five sites along the continental margin, using ray-trace forward modeling. Two southern sites were located in the vicinity of a 30 km long zone where methane gas bubbles escaping from the seafloor were observed during the cruise. The three remaining sites were located along an E-W orientated line in the north of the margin. At the deepest northern site, Vp anomalies indicate the presence of hydrate in the sediment immediately overlying a zone containing free gas up to 100-m thick. The acoustic impedance contrast between the two zones forms a bottom-simulating reflector (BSR) at approximately 195 m below the seabed. The two other sites within the gas hydrate stability zone (GHSZ) do not show the clear presence of a BSR or of gas hydrate. However, anomalously low Vp, indicating the presence of free gas, was modeled for both sites. The hydrate content was estimated from Vp and Vs, using effective-medium theory. At the deepest northern site, modeling suggests a pore-space hydrate concentration of 7-12%, if hydrate forms as part of a connected framework, and about 22% if it is pore-filling. At the two other northern sites, located between the deepest site and the landward limit of the GHSZ, we suggest that hydrate is present in the sediment as inclusions. Hydrate may be present in small quantities at these two sites (4-5%) of the pore space. The variation in lithology for the three sites indicated by high-resolution seismic profiles may control the distribution, concentration and formation of hydrate and free gas.

High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors

ClinicalTrials.gov

2018-04-05

Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (PNET); Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Plasma Cell Neoplasm; Primary Systemic Amyloidosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Neuroblastoma; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Regional Neuroblastoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

From rock to magma and back again: The evolution of temperature and deformation mechanism in conduit margin zones

NASA Astrophysics Data System (ADS)

Heap, Michael J.; Violay, Marie; Wadsworth, Fabian B.; Vasseur, Jérémie

2017-04-01

Explosive silicic volcanism is driven by gas overpressure in systems that are inefficient at outgassing. The zone at the margin of a volcanic conduit-thought to play an important role in the outgassing of magma and therefore pore pressure changes and explosivity-is the boundary through which heat is exchanged from the hot magma to the colder country rock. Using a simple heat transfer model, we first show that the isotherm for the glass transition temperature (whereat the glass within the groundmass transitions from a glass to an undercooled liquid) moves into the country rock when the magma within the conduit can stay hot, or into the conduit when the magma is quasi-stagnant and cools (on the centimetric scale over days to months). We then explore the influence of a migrating viscous boundary on compactive deformation micromechanisms in the conduit margin zone using high-pressure (effective pressure of 40 MPa), high-temperature (up to 800 °C) triaxial deformation experiments on porous andesite. Our experiments show that the micromechanism facilitating compaction in andesite is localised cataclastic pore collapse at all temperatures below the glass transition of the amorphous groundmass glass Tg (i.e., rock). In this regime, porosity is only reduced within the bands of crushed pores; the porosity outside the bands remains unchanged. Further, the strength of andesite is a positive function of temperature below the threshold Tg due to thermal expansion driven microcrack closure. The micromechanism driving compaction above Tg (i.e., magma) is the distributed viscous flow of the melt phase. In this regime, porosity loss is distributed and is accommodated by the widespread flattening and closure of pores. We find that viscous flow is much more efficient at reducing porosity than cataclastic pore collapse, and that it requires stresses much lower than those required to form bands of crushed pores. Our study therefore highlights that temperature excursions can result in a change in deformation micromechanism that drastically alters the mechanical and hydraulic properties of the material within the conduit margin zone, with possible implications for pore pressure augmentation and explosive behaviour.

Seismic Reflection Characteristic and Structure Unit Division of Nanwei Uplift in the Nansha Waters, South China Sea

NASA Astrophysics Data System (ADS)

Guo, L.; Zhan, W.; Yao, Y.

2016-12-01

Nanwei uplift is located in the continent-ocean transition zone at the southern margin of the South China Sea (SCS). It has the structural characteristics in typical passive margin models. Attributed to squeezing action, the anticline and faulted anticline structure were well developed since Oligocene. The development of organic reef and marine mudstone deposit indicated the drifting and subsidence stage. In this area, the structural evolution is not only related to the dynamic systems of rifting, basin spreading and expansion ending, but also to the collisions between different plates. Meanwhile, a large number of continental margin rifting basins with rich oil and gas resources developed in Nanwei uplift. It is meaningful to analyze the characteristics of seismic reflection waves. Also, two main structural unit were divided for studying the special structures and stratigraphic features in this paper. Two high-resolution single-channel seismic Line Nan-1 and Line Nan-2 in the Nansha Waters, acquired by the trial vessel "Shiyan 2" of the South China Sea Institute of Oceanology in 2013, is interpreted and analyzed in this study. The profiles show that there are a lot of normal fault half-garben systems and depressions in NE direction. Five seismic interfaces have been distinguished, named T0,T3,T4,T5 and Tg respectively. It corresponds to different regional unconformities in different geological age which indicated the characteristics of regional tectonics. On the basis of tectonic shape and previous geophysical data, it is believed that the Nanwei uplift zone is mainly composed of two structural units, the southern subsidence belt and northern buried volcanic uplift belt. The general range of zoning is also discussed in this paper. It is considered that the buried volcanic uplift belt mainly involved the marginal area along the southern ocean basin from 63-72 km wide in SE direction, the neighboring subsidence belt in rifting stage is parallel to the buried volcanic uplift belt with 57.5-128 km wide. In addition, the epicenter distributions of sporadic and larger than 4 magnitude earthquakes suggest that the entire Nanwei uplift is still a relatively stable tectonic activity zone, the crustal stability is good.

Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant

ClinicalTrials.gov

2015-08-12

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage II Childhood Lymphoblastic Lymphoma; Stage II Childhood Small Noncleaved Cell Lymphoma; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Childhood Lymphoblastic Lymphoma; Stage III Childhood Small Noncleaved Cell Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Hodgkin Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Childhood Lymphoblastic Lymphoma; Stage IV Childhood Small Noncleaved Cell Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

Architecture of ductile-type passive margins: Geological constraints from the inverted Cretaceous basin of the North-Pyrenean Zone (`Chaînons Béarnais', Western Pyrenees)

NASA Astrophysics Data System (ADS)

Corre, B.; Lagabrielle, Y.; Labaume, P.; Lahfid, A.; Boulvais, P.; Bergamini, G.; Fourcade, S.; Clerc, C. N.; Asti, R.

2017-12-01

Subcontinental lithospheric mantle rocks are exhumed at the foot of magma-poor distal passive margins as a response to extreme stretching of the continental crust. The North-Pyrenean Zone (NPZ) exposes remnants of such extremely stretched paleo-passive margin that represent field analogues to study the processes of continental crust thinning and mantle exhumation. The NPZ results from the inversion of basins opened between the Iberia and Europa plates during Albo-Cenomanian times. The Chaînons Béarnais belt displays a fold-and-thrust structure involving the Mesozoic sedimentary cover associated with peridotite bodies in tectonic contact with Paleozoic basement lenses of small size. Continental extension developed under hot thermal conditions, as demonstrated by the syn-metamorphic Cretaceous ductile deformation affecting both the crustal basement and the Mesozoic cover. In this study, we present structural and geochemical data providing constraints to reconstruct the evolution of this paleo-margin. Field work confirms that the Mesozoic cover is intimately associated with mantle rocks and thin tectonic lenses of middle crust. Micro-structural studies show that the greenschist facies ductile deformation in the crust produced a mylonitic foliation which is always parallel to the crust/mantle contact. The crust/mantle detachment fault is a major shear zone characterized by anastomosed shear bands. It also shows that the pre-rift cover was detached from its bedrock at the Keuper evaporites level and was welded to mantle rocks during their exhumation at the foot of the margin. We show that: (i) the boudinaged pre-rift sediments have undergone drastic syn-metamorphic thinning with the genesis of a S0/S1 foliation and, (ii) the Paleozoic basement has been ductilely deformed, into thin tectonic lenses that remained welded to the exhumed mantle rocks. The ductile behavior is related to the presence of a thick pre- and syn-rift cover acting as an efficient thermal blanket. This new geological data set highlights important characteristics of ductile-type hyper-extended passive margin. Finally, we stress that studying field analogues represents a major tool to better understand the mechanisms of crustal thinning associated with mantle exhumation and their structural inheritance during tectonic inversion.

Active contour configuration model for estimating the posterior ablative margin in image fusion of real-time ultrasound and 3D ultrasound or magnetic resonance images for radiofrequency ablation: an experimental study.

PubMed

Lee, Junkyo; Lee, Min Woo; Choi, Dongil; Cha, Dong Ik; Lee, Sunyoung; Kang, Tae Wook; Yang, Jehoon; Jo, Jaemoon; Bang, Won-Chul; Kim, Jongsik; Shin, Dongkuk

2017-12-21

The purpose of this study was to evaluate the accuracy of an active contour model for estimating the posterior ablative margin in images obtained by the fusion of real-time ultrasonography (US) and 3-dimensional (3D) US or magnetic resonance (MR) images of an experimental tumor model for radiofrequency ablation. Chickpeas (n=12) and bovine rump meat (n=12) were used as an experimental tumor model. Grayscale 3D US and T1-weighted MR images were pre-acquired for use as reference datasets. US and MR/3D US fusion was performed for one group (n=4), and US and 3D US fusion only (n=8) was performed for the other group. Half of the models in each group were completely ablated, while the other half were incompletely ablated. Hyperechoic ablation areas were extracted using an active contour model from real-time US images, and the posterior margin of the ablation zone was estimated from the anterior margin. After the experiments, the ablated pieces of bovine rump meat were cut along the electrode path and the cut planes were photographed. The US images with the estimated posterior margin were compared with the photographs and post-ablation MR images. The extracted contours of the ablation zones from 12 US fusion videos and post-ablation MR images were also matched. In the four models fused under real-time US with MR/3D US, compression from the transducer and the insertion of an electrode resulted in misregistration between the real-time US and MR images, making the estimation of the ablation zones less accurate than was achieved through fusion between real-time US and 3D US. Eight of the 12 post-ablation 3D US images were graded as good when compared with the sectioned specimens, and 10 of the 12 were graded as good in a comparison with nicotinamide adenine dinucleotide staining and histopathologic results. Estimating the posterior ablative margin using an active contour model is a feasible way of predicting the ablation area, and US/3D US fusion was more accurate than US/MR fusion.

Paleomagnetic tests for tectonic reconstructions of the Late Jurassic-Early Cretaceous Woyla Group, Sumatra

NASA Astrophysics Data System (ADS)

Advokaat, Eldert; Bongers, Mayke; van Hinsbergen, Douwe; Rudyawan, Alfend; Marshal, Edo

2017-04-01

SE Asia consists of multiple continental blocks, volcanic arcs and suture zones representing remnants of closing ocean basins. The core of this mainland is called Sundaland, and was formed by accretion of continental and arc fragments during the Paleozoic and Mesozoic. The former positions of these blocks are still uncertain but reconstructions based on tectonostratigraphic, palaeobiogeographic, geological and palaeomagnetic studies indicate the continental terranes separated from the eastern margin of Gondwana. During the mid-Cretaceous, more continental and arc fragments accreted to Sundaland, including the intra-oceanic Woyla Arc now exposed on Sumatra. These continental fragments were derived from Australia, but the former position of the Woyla Arc is unconstrained. Interpretations on the former position of the Woyla Arc fall in two end-member groups. The first group interprets the Woyla Arc to be separated from West Sumatra by a small back-arc basin. This back arc basin opened in the Late Jurassic, and closed mid-Cretaceous, when the Woyla Arc collided with West Sumatra. The other group interprets the Woyla Arc to be derived from Gondwana, at a position close to the northern margin of Greater India in the Late Jurassic. Subsequently the Woyla Arc moved northwards and collided with West Sumatra in the mid-Cretaceous. Since these scenarios predict very different plate kinematic evolutions for the Neotethyan realm, we here aim to place paleomagnetic constraints on paleolatitudinal evolution of the Woyla Arc. The Woyla Arc consists mainly of basaltic to andesitic volcanics and dykes, and volcaniclastic shales and sandstones. Associated limestones with volcanic debris are interpreted as fringing reefs. This assemblage is interpreted as remnants of an Early Cretaceous intra-oceanic arc. West Sumatra exposes granites, surrounded by quartz sandstones, shales and volcanic tuffs. These sediments are in part metamorphosed. This assemblage is interpreted as a Jurassic-Early Cretaceous Andean margin above a NE dipping subduction zone. We sampled limestones of the Woyla Group, and sediments of the West Sumatra margin for paleomagnetic analyses. Here we present new paleomagnetic data from Upper Jurassic-Lower Cretaceous limestones of the Woyla Arc. Preliminary results suggest that the Woyla Arc was formed near equatorial latitudes. This precludes interpretations that the Woyla arc was derived from Gondwana, near the northern Indian margin. To account for (1) synchronous magmatism at the Woyla Arc and the West Sumatra continental margin, and (2) the juxtaposition of unmetamorphosed units of the Woyla Arc to highly metamorphosed units of the West Sumatra margin, we interpret the Woyla Group to be intra-oceanic arc formed above a SW dipping subduction zone in the Early Cretaceous, which was subsequently thrusted over the West Sumatra margin during the mid-Cretaceous.

Benthic foraminiferal assemblage formation: Theory and observation for the European Arctic margin

NASA Astrophysics Data System (ADS)

Loubere, Paul; Rayray, Shan

2016-09-01

We use theory and observation to determine how benthic foraminiferal populations living in a range of sedimentary microenvironments are translated into fossil assemblages along the continental margin of the European Arctic. We examine downcore stained (cell tracker green and rose Bengal) and total species shell abundances through the sediment mixing (bioturbation) zone. This, in combination with porewater geochemical measurements, allows us to establish zones of production and destruction for species' shells, and deduce how the fossil record is being generated by the living community. For many taxa, shell production is high in the upper, oxic, sedimentary layer, but destruction in this zone is also high. Hence, contribution to the fossil record is biased to more infaunal populations and species. Taxa producing near, or below, the anoxic boundary of the sediments are particularly important to the developing fossil record of the fjord environment. We find that taxon relative and absolute abundances change continuously through the biologically active sediment profile. This has implications for reconstructing paleoenvironments using benthic foraminiferal assemblages, and potentially for the geochemistry of individual fossil taxa.

Benthic foraminiferal assemblage formation: Theory and observation for the European Arctic Margin

NASA Astrophysics Data System (ADS)

Loubere, Paul; Rayray, Shan

2016-07-01

We use theory and observation to determine how benthic foraminiferal populations living in a range of sedimentary microenvironments are translated into fossil assemblages along the continental margin of the European Arctic. We examine downcore stained (cell tracker green and rose Bengal) and total species shell abundances through the sediment mixing (bioturbation) zone. This, in combination with porewater geochemical measurements, allows us to establish zones of production and destruction for species' shells, and deduce how the fossil record is being generated by the living community. For many taxa, shell production is high in the upper, oxic, sedimentary layer, but destruction in this zone is also high. Hence, contribution to the fossil record is biased to more infaunal populations and species. Taxa producing near, or below, the anoxic boundary of the sediments are particularly important to the developing fossil record of the fjord environment. We find that taxon relative and absolute abundances change continuously through the biologically active sediment profile. This has implications for reconstructing paleoenvironments using benthic foraminiferal assemblages, and potentially for the geochemistry of individual fossil taxa.

The poleward shift of South Atlantic Convergence Zone in recent decades

NASA Astrophysics Data System (ADS)

Zilli, Marcia T.; Carvalho, Leila M. V.; Lintner, Benjamin R.

2018-05-01

During austral summer (December-January-February or DJF), intense precipitation over central-eastern Brazil is modulated by the South American Monsoon System and the South Atlantic Convergence Zone (SACZ). Previous studies identified spatial variability in precipitation trends over this region, suggestive of a poleward shift of the SACZ in recent years. To identify underlying mechanisms associated with changes in the precipitation intensity and position of the SACZ, decadal averages of observed precipitation and the mean state of the atmosphere and ocean during three different periods from 1979 to 2014 are compared. Results show evidence of decreasing (increasing) average daily precipitation along the equatorward (poleward) margin of the climatological SACZ, likely related to a poleward shift of the convergence zone. Precipitation reduction along the equatorward margin of the SACZ is associated with weakening of the poleward winds along the eastern Brazilian coast and drying of low-to-mid troposphere (700 hPa) over the tropical Atlantic. These changes in circulation and moisture are likely related to the poleward expansion of the South Atlantic Subtropical High.

[Morpho-functional reaction of spleen natural killer cells and macrophages to melatonin administration to the animals kept on different illumination regimens].

PubMed

Shatskikh, O A; Luzikova, E M

2012-01-01

The aim this investigation was to study the changes in the numbers of spleen CD57+ and CD68+ cells (natural killer cells and macrophages respectively) after melatonin administration to the animals kept on different illumination regimens. The experimental animals were given melatonin in dose of 0.03 mg per day for 2 and 4 weeks under conditions of natural illumination or artificial darkening. Spleen paraffin sections were stained using immunohistochemical methods for detection of CD57+ and CD68+ cells. It was shown that long-term administration of melatonin under conditions of natural illumination had an immunosuppressive effect, that was manifested by the depopulation of the marginal zones, white pulp and all the zones of the red pulp, parenchyma loosening and denudation of the reticular stroma of the organ. However, long-term hormone administration under conditions of artificial darkening had an immunostimulatory effect as evidenced by the increased inflow of immunocompetent cells into the spleen, their migration from the white pulp into the marginal zones and emigration into peripheral blood flow, concomitant with the increase in the number of lymphoid nodules. The number of CD57+ and CD68+ cells was increased in splenic periarterial lymphoid sheaths and decreased in B-dependent zones of the organ.

Flexural bending of southern Tibet in a retro foreland setting

PubMed Central

Wang, Erchie; Kamp, Peter J. J.; Xu, Ganqing; Hodges, Kip V.; Meng, Kai; Chen, Lin; Wang, Gang; Luo, Hui

2015-01-01

The highest elevation of the Tibetan Plateau, lying 5,700 m above sea level, occurs within the part of the Lhasa block immediately north of the India-Tibet suture zone (Yarlung Zangbo suture zone, YZSZ), being 700 m higher than the maximum elevation of more northern parts of the plateau. Various mechanisms have been proposed to explain this differentially higher topography and the rock uplift that led to it, invoking crustal compression or extension. Here we present the results of structural investigations along the length of the high elevation belt and suture zone, which rather indicate flexural bending of the southern margin of the Lhasa block (Gangdese magmatic belt) and occurrence of an adjacent foreland basin (Kailas Basin), both elements resulting from supra-crustal loading of the Lhasa block by the Zangbo Complex (Indian plate rocks) via the Great Counter Thrust. Hence we interpret the differential elevation of the southern margin of the plateau as due originally to uplift of a forebulge in a retro foreland setting modified by subsequent processes. Identification of this flexural deformation has implications for early evolution of the India-Tibet continental collision zone, implying an initial (Late Oligocene) symmetrical architecture that subsequently transitioned into the present asymmetrical wedge architecture. PMID:26174578

Angola seismicity

NASA Astrophysics Data System (ADS)

Neto, Francisco António Pereira; França, George Sand; Condori, Cristobal; Sant'Anna Marotta, Giuliano; Chimpliganond, Cristiano Naibert

2018-05-01

This work describes the development of the Angolan earthquake catalog and seismicity distribution in the Southwestern African Plate, in Angola. This region is one of the least seismically active, even for stable continental regions (SCRs) in the world. The maximum known earthquake had a magnitude of 6.0 Ms, while events with magnitudes of 4.5 have return period of about 10 years. Events with magnitude 5 and above occur with return period of about 20 years. Five seismic zones can be confirmed in Angola, within and along craton edges and in the sedimentary basins including offshore. Overall, the exposed cratonic regions tend to have more earthquakes compared to other regions such as sedimentary basins. Earthquakes tend to occur in Archaic rocks, especially inside preexisting weakness zones and in tectonic-magmatic reactivation zones of Mesozoic and Meso-Cenozoic, associated with the installation of a wide variety of intrusive rocks, strongly marked by intense tectonism. This fact can be explained by the models of preexisting weakness zones and stress concentration near intersecting structures. The Angolan passive margin is also a new region where seismic activity occurs. Although clear differences are found between different areas along the passive margin, in the middle near Porto Amboim city, seismic activity is more frequent compared with northwestern and southwestern regions.

Subducting plate geology in three great earthquake ruptures of the western Alaska margin, Kodiak to Unimak

USGS Publications Warehouse

von Huene, Roland E.; Miller, John J.; Weinrebe, Wilhelm

2012-01-01

Three destructive earthquakes along the Alaska subduction zone sourced transoceanic tsunamis during the past 70 years. Since it is reasoned that past rupture areas might again source tsunamis in the future, we studied potential asperities and barriers in the subduction zone by examining Quaternary Gulf of Alaska plate history, geophysical data, and morphology. We relate the aftershock areas to subducting lower plate relief and dissimilar materials in the seismogenic zone in the 1964 Kodiak and adjacent 1938 Semidi Islands earthquake segments. In the 1946 Unimak earthquake segment, the exposed lower plate seafloor lacks major relief that might organize great earthquake rupture. However, the upper plate contains a deep transverse-trending basin and basement ridges associated with the Eocene continental Alaska convergent margin transition to the Aleutian island arc. These upper plate features are sufficiently large to have affected rupture propagation. In addition, massive slope failure in the Unimak area may explain the local 42-m-high 1946 tsunami runup. Although Quaternary geologic and tectonic processes included accretion to form a frontal prism, the study of seismic images, samples, and continental slope physiography shows a previous history of tectonic erosion. Implied asperities and barriers in the seismogenic zone could organize future great earthquake rupture.

Therapeutic and prognostic value of chromosomal AP classification at the blastic phase of Ph-positive chronic myeloid leukemia: comparison of data from Nagasaki University, Japan and Roswell Park Memorial Institute, U.S.A.

PubMed

Sadamori, N; Yao, E; Mine, M; Tokunaga, S; Matsunaga, M; Nakamura, H; Sasagawa, I; Itoyama, T; Kawachi, T; Sandberg, A A

1991-01-01

To assess parameters of therapeutic response and survival after the onset of the blastic phase (BP) in 47 patients with Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML), a number of clinical hematologic, and cytogenetic data at the BP were evaluated. Among the eleven parameters examined, only the chromosomal findings correlated with the therapeutic response and survival after onset of the BP. The patients were divided into three groups on the basis of the chromosome findings in the bone marrow: one, with only a Ph (PP), another with two different clones, i.e., one clone with Ph only and another with additional karyotypic changes (AP), and a third group with only abnormal clones containing karyotypic abnormalities in addition to the Ph (AA). The number of patients with AA was 12, 18 with AP, and 17 with PP. The results were as follows: (1) The percentage of patients with a good therapeutic response was 25% (3/12) in AA, 22% (4/18) in AP, and 76% (13/17) in PP; (2) The median survival after the onset of the BP was 1.5 mo for AA, 2.4 mo for AP, and 7.3 mo for PP. Statistically, there was a significant difference between PP and the other two groups (p < 0.05). These data were reevaluated and compared to those of 64 patients with Ph-positive CML in Roswell Park Memorial Institute (RPMI) who had been reported earlier in 1983.

LXR agonist treatment of blastic plasmacytoid dendritic cell neoplasm restores cholesterol efflux and triggers apoptosis

PubMed Central

Ceroi, Adam; Masson, David; Roggy, Anne; Roumier, Christophe; Chagué, Cécile; Gauthier, Thierry; Philippe, Laure; Lamarthée, Baptiste; Angelot-Delettre, Fanny; Bonnefoy, Francis; Perruche, Sylvain; Biichle, Sabeha; Preudhomme, Claude; Macintyre, Elisabeth; Lagrost, Laurent; Garnache-Ottou, Francine

2016-01-01

Blastic plasmacytoid dendritic cell (PDC) neoplasm (BPDCN) is an aggressive hematological malignancy with a poor prognosis that derives from PDCs. No consensus for optimal treatment modalities is available today and the full characterization of this leukemia is still emerging. We identified here a BPDCN-specific transcriptomic profile when compared with those of acute myeloid leukemia and T-acute lymphoblastic leukemia, as well as the transcriptomic signature of primary PDCs. This BPDCN gene signature identified a dysregulation of genes involved in cholesterol homeostasis, some of them being liver X receptor (LXR) target genes. LXR agonist treatment of primary BPDCN cells and BPDCN cell lines restored LXR target gene expression and increased cholesterol efflux via the upregulation of adenosine triphosphate–binding cassette (ABC) transporters, ABCA1 and ABCG1. LXR agonist treatment was responsible for limiting BPDCN cell proliferation and inducing intrinsic apoptotic cell death. LXR activation in BPDCN cells was shown to interfere with 3 signaling pathways associated with leukemic cell survival, namely: NF-κB activation, as well as Akt and STAT5 phosphorylation in response to the BPDCN growth/survival factor interleukin-3. These effects were increased by the stimulation of cholesterol efflux through a lipid acceptor, the apolipoprotein A1. In vivo experiments using a mouse model of BPDCN cell xenograft revealed a decrease of leukemic cell infiltration and BPDCN-induced cytopenia associated with increased survival after LXR agonist treatment. This demonstrates that cholesterol homeostasis is modified in BPDCN and can be normalized by treatment with LXR agonists which can be proposed as a new therapeutic approach. PMID:27702801

Hurricane Mountain Formation melange: history of Cambro-Ordovician accretion of the Boundary Mountains terrane within the northern Appalachian orthotectonic zone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boone, G.M.; Boudette, E.L.

1985-01-01

The Hurricane Mountain Formation (HMF) melange and associated ophiolitic and volcanogenic formations of Cambrian and lowermost Ordovician age bound the SE margin of the Precambrian Y (Helikian) Chain Lakes Massif in western Maine. HMF melange matrix, though weakly metamorphosed, contains a wide variety of exotic greenschist to amphibolite facies blocks as components of its polymictic assemblage, but blocks of high-grade cratonal rocks such as those of Chain Lakes or Grenville affinity are lacking. Formations of melange exposed in structural culminations of Cambrian and Ordovician rocks NE of the HMF in Maine and in the Fournier Group in New Brunswick aremore » lithologically similar and probably tectonically correlative with the HMF; taken together, they may delineate a common pre-Middle Ordovician tectonic boundary. The authors infer that the Hurricane Mountain and St. Daniel melange belts define the SE and NW margins of the Boundary Mountains accreted terrane (BMT), which may consist of cratonal basement of Chain Lakes affinity extending from eastern Gaspe (deBroucker and St. Julien, 1985) to north-central New Hampshire. The Laurentian continental margin, underlain by Grenville basement, underplated the NW margin of this terrane, marked by the SDF suture zone, in late Cambrian to early Ordovician time, while terranes marked by Cambrian to Tremadocian (.) lithologies dissimilar to the Boundary Mountains terrane were accreted to its outboard margin penecontemporaneously. The docking of the Boundary Mountains terrane and the initiation of its peripheral melanges are equated to the Penobscottian disturbance.« less

A Phase II Study of Doxycycline in Relapsed NHL

ClinicalTrials.gov

2016-10-27

Adult Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma Recurrent; Lymphoma, Follicular; Marginal Zone B-Cell Lymphoma; Malignant Lymphoma - Lymphoplasmacytic; Waldenstrom Macroglobulinemia; Small Lymphocytic Lymphoma; Chronic Lymphocytic Leukemia (CLL); T-Cell Lymphoma

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

PubMed Central

Gawantka, V; Delius, H; Hirschfeld, K; Blumenstock, C; Niehrs, C

1995-01-01

We have identified a novel homeobox gene, Xvent-1, that is differentially expressed in the ventral marginal zone of the early Xenopus gastrula. Evidence is presented from mRNA microinjection experiments for a role for this gene in dorsoventral patterning of mesoderm. First, Xvent-1 is induced by BMP-4, a gene known to be a key regulator of ventral mesoderm development. Second, Xvent-1 and the organizer-specific gene goosecoid are able to interact, directly or indirectly, in a cross-regulatory loop suppressing each other's expression, consistent with their mutually exclusive expression in the marginal zone. Third, microinjection of Xvent-1 mRNA ventralizes dorsal mesoderm. The results suggest that Xvent-1 functions in a ventral signaling pathway that maintains the ventral mesodermal state and antagonizes the Spemann organizer. Images PMID:8557046

Deposition of Franciscan Complex cherts along the paleoequator and accretion to the American margin at tropical paleolatitudes

USGS Publications Warehouse

Hagstrum, J.T.; Murchey, B.L.

1993-01-01

Red radiolarian cherts from three localities within the Franciscan subduction complex of northern California contain three components of remanent magnetization which are best isolated by progressive thermal demagnetization. The available paleomagnetic, biostratigraphic, and geochemical data indicate deposition of these cherts along the paleoequator (0??-2??N or S paleolatitude) between Pliensbachian and Oxfordian time as the oceanic plate moved eastward, relative to North America, beneath the equatorial zone of high biologic productivity. The chert sequences were subsequently accreted to the American continental margin. Plate reconstruction models for the Farallon plate corrobotate low-paleolatitude trajectories from ridge crest to subduction zone, and they imply subsequent northward translation of the Franciscan Complex by strike-slip faulting related to relative motions between the Farallon, Kula, Pacific, and North American plates. -from Authors

Correlation between Spectral Optical Coherence Tomography and Fundus Autofluorescence at the margins of Geographic Atrophy

PubMed Central

Brar, Manpreet; Kozak, Igor; Cheng, Lingyun; Bartsch, Dirk-Uwe G.; Yuson, Ritchie; Nigam, Nitin; Oster, Stephen F.; Mojana, Francesca; Freeman, William R.

2009-01-01

Purpose We studied the appearance of margins of Geographic atrophy in high- resolution optical coherence tomography (OCT) images and correlate those changes with fundus autofluorescence imaging. Design Retrospective observational case study. Methods Patients with geographic atrophy secondary to dry age related macular degeneration (ARMD) were assessed by means of Spectral Domain OCT (Spectralis HRA/OCT; Heidelberg Engineering, Heidelberg, Germany or OTI, Inc, Toronto, Canada) as well as Autofluoresence Imaging (HRA or Spectralis Heidelberg Engineering, Heidelberg, Germany): The outer retinal layer alterations were analyzed in the junctional zone between normal retina and atrophic retina, and correlated with corresponding fundus autofluorescence. Results 23 eyes of 16 patients aged between 62 years to 96 years were examined. There was a significant association between OCT findings and the fundus autofluorescence findings(r=0.67, p<0.0001). Severe alterations of the outer retinal layers at margins on Spectral OCT correspond significantly to increased autofluorescence; Smooth margins on OCT correspond significantly to normal fundus autofluorescence. (Kappa-0.7348, p<0.0001). Conclusion Spectral OCT provides in vivo insight into the pathogenesis of geographic atrophy and its progression. Visualization of reactive changes in the retinal pigment epithelial cells at the junctional zone and correlation with increased fundus autofluorescence; secondary to increased lipofuscin may together serve as determinants of progression of geographic atrophy. PMID:19541290

Geodynamic processes and deformation in orogenic belts

NASA Astrophysics Data System (ADS)

Dennis, John G.; Jacoby, Wolfgang R.

1980-03-01

The development of geosynclines and orogenic belts is related to lithosphere convergence. Initial sediment accumulation implying subsidence, and volcanic activity implying extension and rise of geotherms, are in most cases followed by folding and thrusting suggesting compression and by uplift. In terms of recent analogs, sediment accumulation and crustal extension are characteristic of back-arc spreading; subsequent compression would indicate continent—continent collision; and rise of geotherms most likely requires localized thermal flow (convection) in the asthenosphere. These events are here shown to agree with Andrews and Sleep's (1974) numerical model of asthenosphere flow at converging plate margins. Orthogeosynclinal subsidence appears to be a consequence of subcrustal ablation and lithosphere extension and thinning in active marginal basins. Arc and Andean type magmatism mark the reappearance of ablated and transported, relatively low-density subcrustal material. Collision slows and eventually stops the local convection cell, resulting in local heat accumulation and hence high- T, low- P metamorphism and granitization while marginal basin (orthogeosynclinal) deposits are being compressed into Alpine style orogenic structures. Moreover, closing of the marginal basin leads to subsidiary subduction, which in turn may be responsible for some Alpine style structures. Oceanic trench deposits may become incorporated in orogenic zones, as high- P, low- T metamorphic belts (thalassogeosynclines). Dynamic uplift is a fundamental characteristic of orogeny. Most rising and sinking in orogenic zones can be linked to those asthenosphere processes which are a consequence of Andrews-Sleep convection.

Fifty years of shear zones

NASA Astrophysics Data System (ADS)

Graham, Rodney

2017-04-01

We are here, of course, because 1967 saw the publication of John Ramsay's famous book. Two years later a memorable field trip from Imperial College to the Outer Hebrides saw John on a bleak headland on the coast of North Uist where a relatively undeformed metadolerite within Lewisian (Precambrian) gneisses contained ductile shear zones with metamorphic fabrics in amphibolite facies. One particular outcrop was very special - a shear zone cutting otherwise completely isotropic, undeformed metadolerite, with an incremental foliation starting to develop at 45° to the deformation zone, and increasing in intensity as it approached the shear direction. Here was proof of the process of simple shear under ductile metamorphic conditions - the principles of simple shear outlined in John Ramsay's 1967 book clearly visible in nature, and verified by Ramsay's mathematical proofs in the eventual paper (Ramsay and Graham, 1970). Later work on the Lewisian on the mainland of Scotland, in South Harris, in Africa, and elsewhere applied Ramsay's simple shear principles more liberally, more imprecisely and on larger scale than at Caisteal Odair, but in retrospect it documented what seems now to be the generality of mid and lower crustal deformation. Deep seismic reflection data show us that on passive margins hyper-stretched continental crust (whether or not cloaked by Seaward Dipping Reflectors) seems to have collapsed onto the mantle. Crustal faults mostly sole out at or above the mantle - so the Moho is a detachment- an 'outer marginal detachment', if you like, and, of course, it must be a ductile shear. On non-volcanic margins this shear zone forms the first formed ocean floor before true sea floor spreading gets going to create real oceanic crust. Gianreto Manatschal, Marcel Lemoine and others realised that the serpentinites described in parts of the Alps are exposed remnants of this ductile shear zone. Associated ophicalcite breccias tell of sea floor exposure, while high temperature shear zones with flaser gabbro and amphibolitization must have been developed at deeper levels in the shear zone and 'dragged upwards'. An attempt to justify these assertions will made using outcrop exsmples and some deep Seismic data John Ramsay was always cautious about up-scaling and indulging in large scale tectonic speculations, but without his geometric acumen the big scale picture would have been even less clear. Ramsay, J.G. and Graham, R.H., 1970. Strain variation in shear belts. Canadian Journal of Earth Sciences, 7(3), pp.786-813.

Basins in ARC-continental collisions

USGS Publications Warehouse

Draut, Amy E.; Clift, Peter D.; Busby, Cathy; Azor, Antonio

2012-01-01

Arc-continent collisions occur commonly in the plate-tectonic cycle and result in rapidly formed and rapidly collapsing orogens, often spanning just 5-15 My. Growth of continental masses through arc-continent collision is widely thought to be a major process governing the structural and geochemical evolution of the continental crust over geologic time. Collisions of intra-oceanic arcs with passive continental margins (a situation in which the arc, on the upper plate, faces the continent) involve a substantially different geometry than collisions of intra-oceanic arcs with active continental margins (a situation requiring more than one convergence zone and in which the arc, on the lower plate, backs into the continent), with variable preservation potential for basins in each case. Substantial differences also occur between trench and forearc evolution in tectonically erosive versus tectonically accreting margins, both before and after collision. We examine the evolution of trenches, trench-slope basins, forearc basins, intra-arc basins, and backarc basins during arc-continent collision. The preservation potential of trench-slope basins is low; in collision they are rapidly uplifted and eroded, and at erosive margins they are progressively destroyed by subduction erosion. Post-collisional preservation of trench sediment and trench-slope basins is biased toward margins that were tectonically accreting for a substantial length of time before collision. Forearc basins in erosive margins are usually floored by strong lithosphere and may survive collision with a passive margin, sometimes continuing sedimentation throughout collision and orogeny. The low flexural rigidity of intra-arc basins makes them deep and, if preserved, potentially long records of arc and collisional tectonism. Backarc basins, in contrast, are typically subducted and their sediment either lost or preserved only as fragments in melange sequences. A substantial proportion of the sediment derived from collisional orogenesis ends up in the foreland basin that forms as a result of collision, and may be preserved largely undeformed. Compared to continent-continent collisional foreland basins, arc-continent collisional foreland basins are short-lived and may undergo partial inversion after collision as a new, active continental margin forms outboard of the collision zone and the orogen whose load forms the basin collapses in extension.

Collapse of passive margins by lithospheric damage and plunging grain size

NASA Astrophysics Data System (ADS)

Mulyukova, Elvira; Bercovici, David

2018-02-01

The collapse of passive margins has been proposed as a possible mechanism for the spontaneous initiation of subduction. In order for a new trench to form at the junction between oceanic and continental plates, the cold and stiff oceanic lithosphere must be weakened sufficiently to deform at tectonic rates. Such rates are especially hard to attain in the cold ductile portion of the lithosphere, at which the mantle lithosphere reaches peak strength. The amount of weakening required for the lithosphere to deform in this tectonic setting is dictated by the available stress. Stress in a cooling passive margin increases with time (e.g., due to ridge push), and is augmented by stresses present in the lithosphere at the onset of rifting (e.g., due to drag from underlying mantle flow). Increasing stress has the potential to weaken the ductile portion of the lithosphere by dislocation creep, or by decreasing grain size in conjunction with a grain-size sensitive rheology like diffusion creep. While the increasing stress acts to weaken the lithosphere, the decreasing temperature acts to stiffen it, and the dominance of one effect or the other determines whether the margin might weaken and collapse. Here, we present a model of the thermal and mechanical evolution of a passive margin, wherein we predict formation of a weak shear zone that spans a significant depth-range of the ductile portion of the lithosphere. Stiffening due to cooling is offset by weakening due to grain size reduction, driven by the combination of imposed stresses and grain damage. Weakening via grain damage is modest when ridge push is the only source of stress in the lithosphere, making the collapse of a passive margin unlikely in this scenario. However, adding even a small stress-contribution from mantle drag results in damage and weakening of a significantly larger portion of the lithosphere. We posit that rapid grain size reduction in the ductile portion of the lithosphere can enable, or at least significantly facilitate, the collapse of a passive margin and initiate a new subduction zone. We use this model to estimate the conditions for passive margin collapse for modern and ancient Earth, as well as for Venus.

Subduction zone decoupling/retreat modeling explains south Tibet (Xigaze) and other supra-subduction zone ophiolites and their UHP mineral phases

NASA Astrophysics Data System (ADS)

Butler, Jared P.; Beaumont, Christopher

2017-04-01

The plate tectonic setting in which proto-ophiolite 'oceanic' lithosphere is created remains controversial with a number of environments suggested. Recent opinions tend to coalesce around supra-subduction zone (SSZ) forearc extension, with a popular conceptual model in which the proto-ophiolite forms during foundering of oceanic lithosphere at the time of spontaneous or induced onset of subduction. This mechanism is favored in intra-oceanic settings where the subducting lithosphere is old and the upper plate is young and thin. We investigate an alternative mechanism; namely, decoupling of the subducting oceanic lithosphere in the forearc of an active continental margin, followed by subduction zone (trench) retreat and creation of a forearc oceanic rift basin, containing proto-ophiolite lithosphere, between the continental margin and the retreating subduction zone. A template of 2D numerical model experiments examines the trade-off between strength of viscous coupling in the lithospheric subduction channel and net slab pull of the subducting lithosphere. Three tectonic styles are observed: 1) C, continuous subduction without forearc decoupling; 2) R, forearc decoupling followed by rapid subduction zone retreat; 3) B, breakoff of subducting lithosphere followed by re-initiation of subduction and in some cases, forearc decoupling (B-R). In one case (BA-B-R; where BA denotes backarc) subduction zone retreat follows backarc rifting. Subduction zone decoupling is analyzed using frictional-plastic yield theory and the Stefan solution for the separation of plates containing a viscous fluid. The numerical model results are used to explain the formation of Xigaze group ophiolites, southern Tibet, which formed in the Lhasa terrane forearc, likely following earlier subduction and not necessarily during subduction initiation. Either there was normal coupled subduction before subduction zone decoupling, or precursor slab breakoff, subduction re-initiation and then decoupling. Rapid deep upper-mantle circulation in the models during subduction zone retreat can exhume and emplace material in the forearc proto-ophiolite from as deep as the mantle transition zone, thereby explaining diamonds and other 10-15 GPa UHP phases in Tibetan ophiolites.

Morphology, spatial pattern and sediment of Nitraria tangutorum nebkhas in barchans interdune areas at the southeast margin of the Badain Jaran Desert, China

NASA Astrophysics Data System (ADS)

Yang, YanYan; Liu, LianYou; Shi, PeiJun; Zhang, GuoMing; Qu, ZhiQiang; Tang, Yan; Lei, Jie; Wen, HaiMing; Xiong, YiYing; Wang, JingPu; Shen, LingLing

2015-03-01

To understand the characteristics of the nebkhas in barchan interdune areas, isolated barchan dunes at the southeast margin of the Badain Jaran Desert in China and Nitraria tangutorun nebkhas in the interdune areas were selected, and the morphometric parameters, spatial patterns, and granulometric characteristics of the nebkhas in various interdune zones were compared. According to the locations relative to barchan dunes, the interdune areas were divided into three zones: the windward interdune zone (Zw), the leeward interdune zone (Zl), and the horn interdune zone (Zh). The zone that is proximal to barchan dunes and has never been disturbed by barchan dunes was also selected (Zi). The morphometric parameters were measured through a satellite image and field investigation. The population density and spatial patterns were analyzed using the satellite image, and surface sediment samples of the nebkhas and barchan dunes were collected for grain size analysis. The morphometric parameters of Nitraria tangutorun nebkhas in the interdune zones differ significantly. The nebkhas in Zh are larger than those observed in the other zones, and the nebkhas are the smallest in Zl. In all of the zones, the long-axis orientation of the nebkhas is perpendicular to the prevailing wind direction. The population density of the nebkhas in Zw is relatively higher, whereas the density in Zh and Zl becomes obviously lower. The spatial distribution of nebkhas in all of the zones can be categorized as a dispersed pattern. The sediments of the nebkhas are coarsest in Zh and finest in Zl. In addition, the sediments of the nebkhas in all of the zones are finer than those of barchan dunes. The amount of sand captured by the nebkhas in the interdune areas is approximately 20% of the volume of barchan dunes. The variations of the nebkhas' sizes, spatial pattern and sediment are subjected to migration, flow field and sand transport of barchan dunes and sand accumulation with plant growth in the interdune areas, which suggest complex mutual interactions between barchan dunes and the nebkhas in the interdune areas.

Effects of fluidization of the host sediment on peperite textures: A field example from the Cretaceous Buan Volcanics, SW Korea

NASA Astrophysics Data System (ADS)

Gihm, Yong Sik; Kwon, Chang Woo

2017-04-01

In the Cretaceous Buan Volcanics (SW Korea), blocky and fluidal peperites are hosted in a massive pumiceous lapilli tuff intruded by intermediate dikes. Blocky peperites, the most abundant species, are characterized by polyhedral or platy juvenile clasts and a jigsaw-crack texture. Fluidal peperites occur only along dike margins, where the host sediments are composed of well sorted, fine to very fine ash (fine-grained zone), and are characterized by fluidal or globular juvenile clasts with irregular or ragged margins. The fine-grained zone is interpreted to form by grain size segregation caused by upward moving pore water (fluidization) that has resulted from heat transfer from intruding magma toward waterlogged host sediments during intrusion. With the release of pore water and the selective entrainment of fine-grained ash, fine-grained zones formed within the host sediments. Subsequent interactions between the fine-grained zone and the intruding magma resulted in ductile deformation of the magma before fragmentation, which generated fluidal peperites. Outside the fine-grained zone, intruding magma fragmented in a brittle manner because of the relative deficiency of both pore water and fine-grained ash, resulting in the formation of blocky peperites. The results of this study suggest that redistribution of constituent particles (ash) and interstitial fluids during fluidization resulted in heterogeneous physical conditions of the host sediments, which influenced peperite-forming processes, as reflected by the different peperite textures.

Marginal Ice Zone Bibliography.

DTIC Science & Technology

1985-06-01

A Voyage of Discovery. George Deacon 70th An-niversary Volume, (M. Angel, ed.), Pergamon Press, Oxford, p.15-41. Coachman, L.K., C.A. Barnes, 1961...some polar contrasts. In: S "" RUsium on Antarctic Ice and Water Masses, ( George Deacon, ed.), Sci- 72 Lebedev, A.A., 1968: Zone of possible icing of...Atlantic and Western Europe. British Meteorological Office. Geophysical Memoirs, 4(41). Brost , R.A., J.C. Wyngaard, 1978: A model study of the stably

Preface - 'Biogeochemistry-ecosystem interaction on changing continental margins in the Anthropocene'

NASA Astrophysics Data System (ADS)

Liu, K.-K.; Emeis, Kay-Christian; Levin, Lisa A.; Naqvi, Wajih; Roman, Michael

2015-01-01

This special issue is a product of Workshop 1 of IMBIZO III held in Goa, India in January 2013 (Bundy et al., 2013). This IMBIZO (a Zulu word for gathering) has been organized by IMBER (Integrated Marine Biogeochemistry and Ecosystem Research) biannually since 2008. It employs a format of three concurrent but interacting workshops designed to synthesize information on topical research areas in marine science. Workshop 1 addressed the issue, "Biogeochemistry-ecosystem interaction in changing continental margins," which belongs to the purview of the Continental Margins Working Group (CMWG), co-sponsored by IMBER and LOICZ (Land-Ocean Interaction in the Coastal Zone). As a way to explore the emerging issues that concern the CMWG, the workshop had attracted 25 talks and 18 posters that explored the following topics: Human impacts on continental margins

Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration.

PubMed

Hariri, Amir H; Nittala, Muneeswar G; Sadda, SriniVas R

2016-06-01

To evaluate the spectral-domain optical coherence tomography (SD-OCT) characteristics of the junctional zone corresponding to areas of increased autofluorescence (IAF) at the margin of geographic atrophy (GA) in patients with age-related macular degeneration (AMD). SD-OCT and fundus autofluorescence (FAF) images from untreated eyes with GA available from archived studies at Doheny Image Reading Center were evaluated. Areas of definite decreased autofluorescence (DDAF) corresponding to GA, and areas of IAF at the margins of the GA were manually segmented. Eyes with evidence of IAF were selected. Following manual registration of FAF and OCT data, areas of IAF and normal fluorescence were correlated with OCT features at these locations. Thirty eyes were included. The mean retinal pigment epithelium (RPE) thickness in areas of IAF was 40.6 µm ± 7.69 µm, compared to 28.8 µm ± 7.09 µm in normal adjacent areas (P < .001). Regions of IAF at the junctional zone of GA lesions appear to correspond to thickening of the presumed RPE band on OCT. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:523-527.]. Copyright 2016, SLACK Incorporated.

Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas

ClinicalTrials.gov

2018-03-02

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Progressive Hairy Cell Leukemia, Initial Treatment; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage II Childhood Lymphoblastic Lymphoma; Stage II Childhood Small Noncleaved Cell Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Childhood Lymphoblastic Lymphoma; Stage III Childhood Small Noncleaved Cell Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Hodgkin Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Childhood Lymphoblastic Lymphoma; Stage IV Childhood Small Noncleaved Cell Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia

Phase II trial of vindesine in patients with acute leukemia.

PubMed

Sklaroff, R B; Arlin, Z; Young, C W

1979-01-01

Vindesine was administered to 18 patients with acute leukemia who had failed conventional chemotherapy. Each course of therapy consisted of an iv bolus infusion at a dose of 1-2 mg/m2 given daily x 5-10 days. Of 13 patients with acute lymphoblastic leukemia, two had partial remissions which lasted 2 and 3 months and five had minor responses. One of three patients with acute nonlymphoblastic leukemia and one of two patients with blastic crisis of chronic myelogenous leukemia each had a minor response. The data suggest that vindesine has activity in the treatment of acute leukemia.

Seismic imaging of a transform segment of the Maranhão-Barreirinhas-Ceará margin, NW Brazil

NASA Astrophysics Data System (ADS)

Schnurle, Philippe; Moulin, Maryline; Gallais, Flora; Afilhado, Alexandra; Afonso Dias, Nuno; Soares, José; Loureiro, Afonso; Fuck, Reinhardt; Cupertino, José; Viana, Adriano; Matias, Luís; Evain, Mikael; Aslanian, Daniel

2017-04-01

The structure of the North-East equatorial Brazilian margin was investigated during the MAGIC (Margins of brAzil, Ghana and Ivory Coast) seismic experiment, a project conducted by IFREMER (Institut Francais de Recherche pour l'Exploration de la Mer), UnB (University of Brasilia), FCUL (Faculdade de Ciências da Universidade de Lisboa) and Petrobras. The survey consists of 5 deep seismic profiles totaling 1900 km of marine multi-channel seismic reflection and wide angle acquisition with 143 deployments of short-period OBS's from the IFREMER pool. Three of the profiles were extended into land using Land Seismic Stations (LSS) from the Brazilian pool at a total of 50 points. This study focuses on the MC1 and MC5 wide-angle profiles: MC5 spans NW-SE 720 km in length, from the São Paulo Double Fracture Zone to the Borborema-Cearà margin. MC-1 spans parallel east of MC5, 360 km in length, in the presumed oceanic domain. Our main objective is to understand the fundamental processes which lead to the thinning and finally to the breakup of the continental crust in a specific context of a pull-apart system with two strike-slip borders. The experiment was devised to obtain the 2D structure along the profiles from joint pre-stack depth migration of the reflection data, and tomography and forward modeling of the OBS records. Along the MC1/MC5 wide-angle transects, 5 major sectors are identified: - the São Paulo Double Fracture Zone and the volcanic line associated to the southern São Paulo strike-slip zone presenting a 4.5 km thick volcano-sedimentary basin on top of a 5.5 km thick basement; - the intermediate domain, formed by the 4.5 km thick Basin III, the 7.5 km thick Basin II (interleaved by a 0.5-1 km thick volcanic layer), and the 5.5 km thick Basin I composing the continental slope. While the crust remains about 6 km thick, its acoustic velocity evolves from two-layer typical (4.8-6 km/s and 6.1-6.8 km/s) beneath Basin III to two-layer high velocity (6.1-6.8 km/s and 7.2-7.4 km/s) beneath Basin II and I, interpreted as exhumed lower continental crust; - to the east, the oceanic crust, evolves to an 2 layers crust 5 km thick, characterized by typical oceanic crustal velocities and also overlain by 5.5 km of sedimentary deposits, spanning between the two main fracture zones that fringe the Maranhão-Barreirinhas-Ceará segment; - the 50 km wide necking zone, forming the Parnaiba Platform and associated Ceará Basins, where the upper and lower crust thin abruptly; - the Medio Coreaù and Ceará Central thrust belt, where the unthinned continental crust thickness reaches 32 km. Keywords: North-East equatorial Brazil, transform margin, deep seismic structure

Retrodeforming the Arabia-Eurasia collision zone : Age of collision and magnitude of continental subduction

NASA Astrophysics Data System (ADS)

McQuarrie, N.; van Hinsbergen, D. J. J.

2012-04-01

When did continents collide, and how is convergence partitioned after collision are first order questions that seem to defy consensus along the Alpine-Himalyan orogen. Estimates on the age of collision for Arabia and Eurasia range from late Cretaceous to Pliocene, based on a wide variety of presumed geologic responses. Both lower Miocene synorgenic strata with growth structures adjacent to the main Zagros fault and upper Oligocene to lower Miocene overlap strata over post-collisional thrusts are derived from Eurasia and require that collision was underway at least by ~25-24 Ma. However, upper plate deformation, exhumation and sedimentation are used to argue for an older, 35 Ma collision age. Africa-North America-Eurasia plate circuit rotations, combined with Red Sea rotations provides precise estimates of the relative positions between the northern Arabian margin and the southern Eurasia margin. Plate circuits indicate, from NW to SE along the collision zone 490-650 km of post-25 Ma Arabia-Eurasia convergence and 810-1070 km since 35 Ma. To assess the consequences of these collision ages for the amount of Arabian continental subduction, we compile all documented shortening within the orogen. The Zagros fold-thrust belt consists of thrusted upper crust that was offscraped from subducted Arabian continental lithosphere. Balanced cross-sections give 105-180 km of Zagros shortening (including estimates from the Zagros proper, 45-90 km, and the Zagros "crush" zone, 60-90 km). Shortening within Eurasia is estimated to be 53-75 km through the Kopet Dagh and Alborz Mountains, plus 38 km across Central Iran. These estimates suggest that the orogen has shortened 200 to 300 km since the early Miocene. Both a 25 and a 35 Ma collision estimate thus requires that a considerable portion of the Arabian plate subducted without recognized accretion of its upper crust. To balance plate circuits and documented shortening requires whole-sale subduction of ~500-800 km of continental crust since 35 Ma; for a 25 Ma collision this would be between 190-450 km. The ophiolitic fragments preserved along the suture zone allow us to test the magnitude of possible continental subduction. The Oman Ophiolite preserves the geometry and distance over which ophiolites obduced over the northern margin of Arabia in the late Cretaceous. The distance from the southwestern edge of the ophiolite to the northeastern edge of the continent is 180 km, suggesting that the Arabian continental margin plus overlying ophiolites may have extended ~200 km beyond the Main Zagros fault. Assuming that 200 km of Arabian continental margin and overlying ophiolites subducted entirely, except the few remnant ophiolite slivers remaining in the suture zone, would reconstruct ~ 400-500 km of post-collisional Arabia-Eurasia convergence, consistent with a ~25 Ma collision age. As much as 500-800 km of continental subduction required by an earlier (~35 Ma) collision age seems unlikely.

Deciphering the 3-D distribution of fluid along the shallow Hikurangi subduction zone using P- and S-wave attenuation

NASA Astrophysics Data System (ADS)

Eberhart-Phillips, Donna; Bannister, Stephen; Reyners, Martin

2017-11-01

We use local earthquake velocity spectra to solve for the 3-D distribution of P- and S-wave attenuation in the shallow Hikurangi subduction zone in the North Island of New Zealand to gain insight into how fluids control both the distribution of slip rate deficit and slow-slip events at the shallow plate interface. Qs/Qp gives us information on the 3-D distribution of fluid saturation, which we can compare with the previously determined 3-D distribution of Vp/Vs, which gives information on pore fluid pressure. The Hikurangi margin is unusual, in that a large igneous province (the Hikurangi Plateau) is being subducted. This plateau has had two episodes of subduction-first at 105-100 Ma during north-south convergence with Gondwana, and currently during east-west convergence between the Pacific and Australian plates. We find that in the southern part of the subduction zone, where there is a large deficit in slip rate at the plate interface, the plate interface region is only moderately fluid-rich because the underlying plateau had already had an episode of dehydration during Gondwana subduction. But fluid pressure is relatively high, due to an impermeable terrane in the upper plate trapping fluids below the plate interface. The central part of the margin, where the slip rate deficit is very low, is the most fluid-rich part of the shallow subduction zone. We attribute this to an excess of fluid from the subducted plateau. Our results suggest this part of the plateau has unusually high fracture permeability, on account of it having had two episodes of bending-first at the Gondwana trench and now at the Hikurangi Trough. Qs/Qp is consistent with fluids migrating across the plate interface in this region, leaving it drained and producing high fluid pressure in the overlying plate. The northern part of the margin is a region of heterogeneous deficit in slip rate. Here the Hikurangi Plateau is subducting for the first time, so there is less fluid available from its dehydration than in the central region. Fluid pressure in the overlying plate is high, but Qs/Qp indicates that it is not uniformly fluid-rich. This heterogeneity is consistent with the rough topography of the plateau, including seamounts which entrain fluid-rich sediments. Deep slow-slip events in the southern part of the margin occur where the Moho of the overlying plate meets the plate interface, as typically seen in other deep slow-slip events worldwide. But in the central and northern parts of the margin, the locations of shallow slow-slip events appear to be controlled by a shallow brittle-viscous transition within the fluid-rich upper plate. There is also evidence that a major fault zone in the overlying plate might bleed off some of the high fluid pressure promoting slow-slip events.

Potential for deep basin-centered gas accumulation in Hanna Basin, Wyoming

USGS Publications Warehouse

Wilson, Michael S.; Dyman, Thaddeus S.; Nuccio, Vito F.

2001-01-01

The potential for a continuous-type basin-centered gas accumulation in the Hanna Basin in Carbon County, Wyoming, is evaluated using geologic and production data including mud-weight, hydrocarbon-show, formation-test, bottom-hole-temperature, and vitrinite reflectance data from 29 exploratory wells. This limited data set supports the presence of a hypothetical basin-centered gas play in the Hanna Basin. Two generalized structural cross sections illustrate our interpretations of possible abnormally pressured compartments. Data indicate that a gas-charged, overpressured interval may occur within the Cretaceous Mowry, Frontier, and Niobrara Formations at depths below 10,000 ft along the southern and western margins of the basin. Overpressuring may also occur near the basin center within the Steele Shale and lower Mesaverde Group section at depths below 18,000 to 20,000 ft. However, the deepest wells drilled to date (12,000 to 15,300 ft) have not encountered over-pressure in the basin center. This overpressured zone is likely to be relatively small (probably 20 to 25 miles in diameter) and is probably depleted of gas near major basement reverse faults and outcrops where gas may have escaped. Water may have invaded reservoirs through outcrops and fracture zones along the basin margins, creating an extensive normally pressured zone. A zone of subnormal pressure also may exist below the water-saturated, normal-pressure zone and above the central zone of overpressure. Subnormal pressures have been interpreted in the center of the Hanna Basin at depths ranging from 10,000 to 25,000 ft based on indirect evidence including lost-circulation zones. Three wells on the south side of the basin, where the top of the subnormally pressured zone is interpreted to cut across stratigraphic boundaries, tested the Niobrara Formation and recovered gas and oil shows with very low shut-in pressures.

The South China sea margins: Implications for rifting contrasts

USGS Publications Warehouse

Hayes, D.E.; Nissen, S.S.

2005-01-01

Implications regarding spatially complex continental rifting, crustal extension, and the subsequent evolution to seafloor spreading are re-examined for the northern and southern-rifted margins of the South China Sea. Previous seismic studies have shown dramatic differences in the present-day crustal thicknesses as the manifestations of the strain experienced during the rifting of the margin of south China. Although the total crustal extension is presumed to be the same along the margin and adjacent ocean basin, the amount of continental crustal extension that occurred is much less along the east and central segments of the margin than along the western segment. This difference was accommodated by the early formation of oceanic crust (creating the present-day South China Sea basin) adjacent to the eastern margin segment while continued extension of continental crust was sustained to the west. Using the observed cross-sectional areas of extended continental crust derived from deep penetration seismics, two end-member models of varying rift zone widths and varying initial crustal thicknesses are qualitatively examined for three transects. Each model implies a time difference in the initiation of seafloor spreading inferred for different segments along the margin. The two models examined predict that the oceanic crust of the South China Sea basin toward the west did not begin forming until sometime between 6-12 my after its initial formation (???32 Ma) toward the east. These results are compatible with crustal age interpretations of marine magnetic anomalies. Assuming rifting symmetry with conjugate margin segments now residing along the southern portions of the South China Sea basin implies that the total width of the zone of rifting in the west was greater than in the east by about a factor of two. We suggest the most likely causes of the rifting differences were east-west variations in the rheology of the pre-rift crust and associated east-west variations in the thermal structure of the pre-rift lithosphere. The calculated widths of rifted continental crust for the northern and southern margins, when combined with the differential widths of seafloor generated during the seafloor spreading phase, indicate the total crustal extension that occurred is about 1100 km and is remarkably consistent to within ???10% for all three (eastern, central, western) segments examined. ?? 2005 Elsevier B.V. All rights reserved.

Structure and evolution of the eastern Gulf of Aden: insights from magnetic and gravity data (Encens-Sheba MD117 cruise)

NASA Astrophysics Data System (ADS)

d'Acremont, Elia; Leroy, Sylvie; Maia, Marcia; Patriat, Philippe; Beslier, Marie-Odile; Bellahsen, Nicolas; Fournier, Marc; Gente, Pascal

2006-06-01

Magnetic and gravity data gathered during the Encens-Sheba cruise (2000 June) in the eastern Gulf of Aden provide insights on the structural evolution of segmentation from rifted margins to incipient seafloor spreading. In this study, we document the conjugate margins asymmetry, confirm the location of the ocean-continent transition (OCT) previously proposed by seismic data, and describe its deep structure and segmentation. In the OCT, gravity models indicate highly thinned crust while magnetic data indicate presence of non-oceanic high-amplitude magnetic anomalies where syn-rift sediments are not observed. Thus, the OCT could be made of ultra-stretched continental crust intruded by magmatic bodies. However, locally in the north, the nature of the OCT could be either an area of ultra-slow spreading oceanic crust or exhumed serpentinized mantle. Between the Alula-Fartak and Socotra fracture zones, the non-volcanic margins and the OCT are segmented by two N027°E-trending transfer fault zones. These transfer zones define three N110°E-trending segments that evolve through time. The first evidence of oceanic spreading corresponds to the magnetic anomaly A5d and is thus dated back to 17.6 Ma at least. Reconstruction of the spreading process suggests a complex non-uniform opening by an arc-like initiation of seafloor spreading in the OCT. The early segmentation appears to be directly related to the continental margin segmentation. The spreading axis segmentation evolved from three segments (17.6 to 10.95 Ma) to two segments (10.95 Ma to present). At the onset of the spreading process, the western segment propagated eastwards, thus reducing the size of the central segment. The presence of a propagator could explain the observed spreading asymmetry with the northern flank of the Sheba ridge being wider than the southern one.

When Boundary Layers Collide: Plumes v. Subduction Zones

NASA Astrophysics Data System (ADS)

Moresi, L. N.; Betts, P. G.; Miller, M. S.; Willis, D.; O'Driscoll, L.

2014-12-01

Many subduction zones retreat while hotspots remain sufficiently stable in the mantle to provide an approximate reference frame. As a consequence, the mantle can be thought of as an unusual convecting system which self-organises to promote frequent collisions of downgoing material with upwellings. We present three 3D numerical models of subduction where buoyant material from a plume head and an associated ocean-island chain or plateau produce flat slab subduction and deformation of the over-riding plate. We observe transient instabilities of the convergent margin including: contorted trench geometry; trench migration parallel with the plate margin; folding of the subducting slab and orocline development at the convergent margin; and transfer of the plateau to the overriding plate. The presence of plume material beneath the oceanic plateau causes flat subduction above the plume, resulting in a "bowed" shaped subducting slab. In the absence of a plateau at the surface, the slab can remain uncoupled from the over-riding plate during very shallow subduction and hence there is very little shortening at the surface or advance of the plate boundary. In plateau-only models, plateau accretion at the edge of the overriding plate results in trench migration around the edge of the plateau before subduction re-establishes directly behind the trailing edge of the plateau. The plateau shortens during accretion and some plateau material subducts. In a plateau-plus-plume model, accretion is associated with rapid trench advance as the flat slab drives the plateau into the margin. This indentation stops once a new convergent boundary forms close to the original trench location. A slab window formed beneath the accreted plateau allows plume material to flow from beneath the subducting plate to the underside of the overriding plate. In all of these models the subduction zone maintains a relatively stable configuration away from the buoyancy anomalies within the downgoing plate. The models provide a dynamic context for plateau and plume accretion in accretionary orogenic systems.

Cadaveric Assessment of Lip Injections: Locating the Serious Threats.

PubMed

Tansatit, Tanvaa; Apinuntrum, Prawit; Phetudom, Thavorn

2017-04-01

Lip augmentation could be a possible cause of blindness following filler injections. This study evaluated the risk by simulating clinical scenarios of marginal injections to the upper and lower lips and then evaluated the risk of vascular injuries. A 22G cannula was inserted bilaterally along the wet-dry junction of the upper and lower lip margins in fifteen cadavers, and then both lips were dissected to verify possible injuries to the superior and inferior labial arteries. The position of the labial arteries in the vermilion zone was documented to determine the appropriate injection technique. In the marginal injections to the lips, arterial injuries occurred at the medial segment of the vermilion zone of both the upper and lower lips, at the terminal part of the labial arteries or a distal branch. Considering arterial anatomy, the upper lip has a higher chance of arterial injury than the lower lip. The cannula should not be inserted in the submucosa as it is recommended to evert the vermilion because both the superior and inferior labial arteries are located in the submucosa of the medial and middle segments of the vermilion in all specimens. Awareness of the possibility of vascular injury is necessary during injections of the medial segments of the vermilion of the lips. Vermilion border and marginal injections are recommended for safe and effective lip augmentation. Deep injection around the oral commissure and submucosal injection of the medial and middle segments of the vermilion zone are prohibited because of the high risk of arterial injury. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Serpentinisation and fluid flow associated with a detachment fault in Tasna OCT, South-east Switzerland

NASA Astrophysics Data System (ADS)

Engström, A. V.; Skelton, A. D.

2003-04-01

The well-studied Iberia Abyssal Plain (ODP legs 149 and 173) is a non-volcanic passive margin where continental crust and oceanic crust are separated by a “mantle window” composed of serpentinised peridotites. The exhumation of the mantle at this transitional zone is under debate and several models involving detachment faulting, shear zones or magmatic intrusions have been proposed to explain the formation of the ocean-continent transition (OCT). The mechanical behaviour of serpentinite, with its low density, strength and permeability, and the timing of the serpentinisation process in relation to the exhumation, are crucial parameters in understanding non-volcanic rifting processes. Beneath Iberia Abyssal Plain, sampling is restricted to ocean ridges, the recovery is very poor and in addition, drillcores only give one-dimensional data, implicitly any data is not statistically well represented. However, there are several land analogues of past ocean-continent margins which give excellent opportunities to study the timing and evolution of fluids and serpentinisation in several dimensions. The Tasna OCT is a “mantle window” situated in the Swiss Alps displaying exhumed mantle (serpentinised peridotite) in contact with basement rocks or sediments. For this study several sampling profiles have been conducted across the mantle boundary. Field observations together with ignition experiments and thin section analyses indicate that the degree of serpentinisation is not continously increasing with depth as may be expected. In contrast, high serpentinite contents were recorded at the top of the mantle sequence as well as deeper down. The general pattern of serpentinisation shows “saw tooth” geometry as the content fluctuate from high to low and back to higher values again. This implies that the fluid flow has been channeled. Oxygen isotope studies from the Iberia margin (Skelton and Valley 2000) show deformation channeled fluid flow. Several heavily eroded sections in the Tasna OCT may very well correspond with the postulated shear zones in the Iberia margin localizing the fluid.

ODP Leg 210 Drills the Newfoundland Margin in the Newfoundland-Iberia Non-Volcanic Rift

NASA Astrophysics Data System (ADS)

Tucholke, B. E.; Sibuet, J.

2003-12-01

The final leg of the Ocean Drilling Project (Leg 210, July-September 2003) was devoted to studying the history of rifting and post-rift sedimentation in the Newfoundland-Iberia rift. For the first time, drilling was conducted in the Newfoundland Basin along a transect conjugate to previous drill sites on the Iberia margin (Legs 149 and 173) to obtain data on a complete `non-volcanic' rift system. The prime site during this leg (Site 1276) was drilled in the transition zone between known continental crust and known oceanic crust at chrons M3 and younger. Extensive geophysical work and deep-sea drilling have shown that this transition-zone crust on the conjugate Iberia margin is exhumed continental mantle that is strongly serpentinized in its upper part. Transition-zone crust on the Newfoundland side, however, is typically a kilometer or more shallower and has much smoother topography, and seismic refraction data suggest that the crust may be thin (about 4 km) oceanic crust. A major goal of Site 1276 was to investigate these differences by sampling basement and a strong, basinwide reflection (U) overlying basement. Site 1276 was cored from 800 to 1737 m below seafloor with excellent recovery (avg. 85%), bottoming in two alkaline diabase sills >10 m thick that are estimated to be 100-200 meters above basement. The sills have sedimentary contacts that show extensive hydrothermal metamorphism. Associated sediment structural features indicate that the sills were intruded at shallow levels within highly porous sediments. The upper sill likely is at the level of the U reflection, which correlates with lower Albian - uppermost Aptian(?) fine- to coarse-grained gravity-flow deposits. Overlying lower Albian to lower Oligocene sediments record paleoceanographic conditions similar to those on the Iberia margin and in the main North Atlantic basin, including deposition of `black shales'; however, they show an extensive component of gravity-flow deposits throughout.

Safety and Tolerability of HSC835 in Patients With Hematological Malignancies

ClinicalTrials.gov

2017-04-03

Acute Myelocytic Leukemia; Acute Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Myelodysplastic Syndrome; Chronic Lymphocytic Leukemia; Marginal Zone Lymphoma; Follicular Lymphomas; Large-cell Lymphoma; Lymphoblastic Lymphoma; Burkitt's Lymphoma; High Grade Lymphomas; Mantle-cell Lymphoma; Lymphoplasmacytic Lymphoma

International Arctic Research Programs

DTIC Science & Technology

1989-07-01

beryllium graphite - (moonstone) cerium marble garnet chrniun ol ivine gronlandite copper phosphorus jasper gold soapstone kornerupine iron sulphur...Green- from the magnetic pole to the auroral zone. landic sea under marginal conditions where Besides these groundbased activities, mea- surements of

Optimization of interneuron function by direct coupling of cell migration and axonal targeting.

PubMed

Lim, Lynette; Pakan, Janelle M P; Selten, Martijn M; Marques-Smith, André; Llorca, Alfredo; Bae, Sung Eun; Rochefort, Nathalie L; Marín, Oscar

2018-06-18

Neural circuit assembly relies on the precise synchronization of developmental processes, such as cell migration and axon targeting, but the cell-autonomous mechanisms coordinating these events remain largely unknown. Here we found that different classes of interneurons use distinct routes of migration to reach the embryonic cerebral cortex. Somatostatin-expressing interneurons that migrate through the marginal zone develop into Martinotti cells, one of the most distinctive classes of cortical interneurons. For these cells, migration through the marginal zone is linked to the development of their characteristic layer 1 axonal arborization. Altering the normal migratory route of Martinotti cells by conditional deletion of Mafb-a gene that is preferentially expressed by these cells-cell-autonomously disrupts axonal development and impairs the function of these cells in vivo. Our results suggest that migration and axon targeting programs are coupled to optimize the assembly of inhibitory circuits in the cerebral cortex.

Paleocene calcareous nannofossils biostratigraphy from the Sergipe Sub-basin, northeastern Brazil: Implications for this depositional environment

NASA Astrophysics Data System (ADS)

Andrade Oliveira, Geize Carolinne Correia; de Oliveira, Rick Souza; Monte Guerra, Rodrigo; de Lima Filho, Mario Ferreira

2018-03-01

This study reports on the biostratigraphy of Paleocene calcareous nannofossils and paleoenvironmental inferences based on five wells drilled on the offshore portion of the Sergipe Sub-basin. Five biostratigraphic zones were defined for the Paleocene in zones of Brazilian continental margin basins N-305, N-307, N-330, N-340 and N-350, and four hiatuses were identified based on the absence of marker species. These hiatuses were interpreted as excavations originated by turbulent to hyperpycnal flows, revealing an important application of biostratigraphy to better understand depositional environments that are often limited by little variation in lithology or low variation in the well log patterns. In Paleoecological terms, the Sergipe Sub-basin, in the Paleocene, experienced geological and environmental events similar to those of other sedimentary basins on the eastern passive continental margin of Brazil, but has a more complete biostratigraphic record of calcareous nannofossils.

Multi-frequency SAR, SSM/I and AVHRR derived geophysical information of the marginal ice zone

NASA Technical Reports Server (NTRS)

Shuchman, R. A.; Onstott, R. G.; Wackerman, C. C.; Russel, C. A.; Sutherland, L. L.; Johannessen, O. M.; Johannessen, J. A.; Sandven, S.; Gloerson, P.

1991-01-01

A description is given of the fusion of synthetic aperture radar (SAR), special sensor microwave imager (SSM/I), and NOAA Advanced Very High Resolution Radiometer (AVHRR) data to study arctic processes. These data were collected during the SIZEX/CEAREX experiments that occurred in the Greenland Sea in March of 1989. Detailed comparisons between the SAR, AVHRR, and SSM/I indicated: (1) The ice edge position was in agreement to within 25 km, (2) The SSM/I SAR total ice concentration compared favorably, however, the SSM/I significantly underpredicted the multiyear fraction, (3) Combining high resolution SAR with SSM/I can potentially map open water and new ice features in the marginal ice zone (MIZ) which cannot be mapped by the single sensors, and (4) The combination of all three sensors provides accurate ice information as well as sea surface temperature and wind speeds.

L-form plastics in the treatment of post-burn trophic ulcers and cicatrices of the foot calcaneal area.

PubMed

Shakirov, Babur M; Tagaev, Komil R; Tursunov, Bachron S; Achtamov, Dgamshed A

2009-03-01

The burn trauma of the posterior surface of calcaneus region and ankle joint followed by cicatrix formation in the Achilles tendon zone is often complicated by unhealing trophic ulcers. Eleven patients (seven men and four women, aged 9-54 years) have been operated on under our observation for prolonged unhealing ulcers and cicatrices located in the Achilles tendon zone. After cicatrices dissection, L-form plastic surgery was performed. The postoperative period was smooth; a skin graft was appropriately fixed to the proper tissues and the wound margins. Good results were achieved in 10 cases, and no complications were noted. However, in only one patient a marginal necrosis of the external talus part adjoining the ulcer due to tissue changes has been noted, but that had no influence on the good results of the operation.

A coupled dynamic-thermodynamic model of an ice-ocean system in the marginal ice zone

NASA Technical Reports Server (NTRS)

Hakkinen, Sirpa

1987-01-01

Thermodynamics are incorporated into a coupled ice-ocean model in order to investigate wind-driven ice-ocean processes in the marginal zone. Upswelling at the ice edge which is generated by the difference in the ice-air and air-water surface stresses is found to give rise to a strong entrainment by drawing the pycnocline closer to the surface. Entrainment is shown to be negligible outside the areas affected by the ice edge upswelling. If cooling at the top is included in the model, the heat and salt exchanges are further enhanced in the upswelling areas. It is noted that new ice formation occurs in the region not affected by ice edge upswelling, and it is suggested that the high-salinity mixed layer regions (with a scale of a few Rossby radii of deformation) will overturn due to cooling, possibly contributing to the formation of deep water.

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

PubMed

Newman, Rebecca; Ahlfors, Helena; Saveliev, Alexander; Galloway, Alison; Hodson, Daniel J; Williams, Robert; Besra, Gurdyal S; Cook, Charlotte N; Cunningham, Adam F; Bell, Sarah E; Turner, Martin

2017-06-01

RNA-binding proteins of the ZFP36 family are best known for inhibiting the expression of cytokines through binding to AU-rich elements in the 3' untranslated region and promoting mRNA decay. Here we identified an indispensable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 and IRF8, which are known to enforce the follicular B cell phenotype. These mechanisms emphasize the importance of integrating transcriptional and post-transcriptional processes by RNA-binding proteins for maintaining cellular identity among closely related cell types.

Maintenance of the marginal zone B cell compartment specifically requires the RNA-binding protein ZFP36L1

PubMed Central

Newman, Rebecca; Ahlfors, Helena; Saveliev, Alexander; Galloway, Alison; Hodson, Daniel J; Williams, Robert; Besra, Gurdyal S.; Cook, Charlotte N; Cunningham, Adam F; Bell, Sarah E; Turner, Martin

2017-01-01

RNA binding proteins (RBP) of the ZFP36 family are best known for inhibiting the expression of cytokines through binding to AU rich elements in the 3’UTR and promoting mRNA decay. Here we show an indispensible role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal zone (MZ) B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene expression program related to signaling, cell-adhesion and locomotion, in part by limiting the expression of the transcription factors KLF2 and IRF8, which are known to enforce the follicular B cell phenotype. These mechanisms emphasize the importance of integrating transcriptional and post-transcriptional processes by RBP for maintaining cellular identity between closely related cell types. PMID:28394372

Collision of EBV-associated gastric carcinoma and primary gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the remnant stomach.

PubMed

Akiba, Jun; Nakane, Tomoyuki; Arakawa, Fumiko; Ohshima, Koichi; Yano, Hirohisa

2010-02-01

Reported herein is a case of EBV-associated gastric carcinoma with primary gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 69-year-old Japanese man was found to have an ulcer lesion in his stomach on endoscopy, and a biopsy indicated malignancy. He underwent gastrectomy. Microscopically the tumor had features typical of lymphoepithelioma-like carcinoma. The neoplastic epithelial cells proliferated in a trabecular fashion. On in situ hybridization for EBV-encoded RNA, positive signals were observed in most neoplastic epithelial cells. Numerous lymphocytes surrounded the neoplastic epithelial cells. In the stroma, numerous lymphocytes with mild atypia were positive for CD20 and CD79a. In addition, monoclonal proliferation of B cells was confirmed on polymerase chain reaction for IgH. These findings supported MALT lymphoma. The coexistence of EBV-associated gastric carcinoma and MALT lymphoma is extremely rare.

Image of the Moho across the continent-ocean transition, US east coast

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holbrook, W.S.; Purdy, G.M.; Reiter, E.C.

1992-03-01

Strong wide-angle reflections from the Moho were recorded by ocean-bottom seismic instruments during the 1988 Carolina Trough multichannel seismic experiment, in an area where the Moho is difficult to detect with vertical-incidence seismic data. Prestack depth migration of these reflections has enabled the construction of a seismic image of the Moho across the continent-ocean transition of a sedimented passive margin. The Moho rises across the margin at a slope of 10{degree}-12{degree}, from a depth of about 33 km beneath the continental shelf to 20 km beneath the outer rise. This zone of crustal thinning defines a distinct, 60-70-km-wide continent-ocean transitionmore » zone. The authors interpret the Moho in the Carolina Trough as a Jurassic feature, formed by magmatic intrusion and underplating during the rifting of Pangea.« less

Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

PubMed

Balázs, Mercedesz; Martin, Flavius; Zhou, Tong; Kearney, John

2002-09-01

Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen. In a systemic infection, CD11c(lo) DC, but not neutrophils, provide critical survival signals, which can be inhibited by TACI-Fc, to antigen-specific MZ B cells and promote their differentiation into IgM-secreting plasmablasts. In a local TI response, peritoneal cavity macrophages provide similar support to B1 B-derived Ag-specific blasts. In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses.

Wave attenuation in the marginal ice zone during LIMEX

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Vachon, Paris W.; Peng, Chih Y.; Bhogal, A. S.

1992-01-01

The effect of ice cover on ocean-wave attenuation is investigated for waves under flexure in the marginal ice zone (MIZ) with SAR image spectra and the results of models. Directional wavenumber spectra are taken from the SAR image data, and the wave-attenuation rate is evaluated with SAR image spectra and by means of the model by Liu and Mollo-Christensen (1988). Eddy viscosity is described by means of dimensional analysis as a function of ice roughness and wave-induced velocity, and comparisons are made with the remotely sensed data. The model corrects the open-water model by introducing the effects of a continuous ice sheet, and turbulent eddy viscosity is shown to depend on ice thickness, floe sizes, significant wave height, and wave period. SAR and wave-buoy data support the trends described in the model results, and a characteristic rollover is noted in the model and experimental wave-attenuation rates at high wavenumbers.

Recent advances in understanding the biology of marginal zone lymphoma

PubMed Central

Zucca, Emanuele

2018-01-01

There are three different marginal zone lymphomas (MZLs): the extranodal MZL of mucosa-associated lymphoid tissue (MALT) type (MALT lymphoma), the splenic MZL, and the nodal MZL. The three MZLs share common lesions and deregulated pathways but also present specific alterations that can be used for their differential diagnosis. Although trisomies of chromosomes 3 and 18, deletions at 6q23, deregulation of nuclear factor kappa B, and chromatin remodeling genes are frequent events in all of them, the three MZLs differ in the presence of recurrent translocations, mutations affecting the NOTCH pathway, and the transcription factor Kruppel like factor 2 ( KLF2) or the receptor-type protein tyrosine phosphatase delta ( PTPRD). Since a better understanding of the molecular events underlying each subtype may have practical relevance, this review summarizes the most recent and main advances in our understanding of the genetics and biology of MZLs. PMID:29657712

Atmospheric boundary layer modification in the marginal ice zone

NASA Technical Reports Server (NTRS)

Bennett, Theodore J., Jr.; Hunkins, Kenneth

1986-01-01

A case study of the Andreas et al. (1984) data on atmospheric boundary layer modification in the marginal ice zone is made. The model is a two-dimensional, multilevel, linear model with turbulence, lateral and vertical advection, and radiation. Good agreement between observed and modeled temperature cross sections is obtained. In contrast to the hypothesis of Andreas et al., the air flow is found to be stable to secondary circulations. Adiabatic lifting and, at long fetches, cloud top longwave cooling, not an air-to-surface heat flux, dominate the cooling of the boundary layer. The accumulation with fetch over the ice of changes in the surface wind field is shown to have a large effect on estimates of the surface wind stress. It is speculated that the Andreas et al. estimates of the drag coefficient over the compact sea ice are too high.

Multisensor comparison of ice concentration estimates in the marginal ice zone

NASA Technical Reports Server (NTRS)

Burns, B. A.; Cavalieri, D. J.; Gloersen, P.; Keller, M. R.; Campbell, W. J.

1987-01-01

Aircraft remote sensing data collected during the 1984 summer Marginal Ice Zone Experiment in the Fram Strait are used to compare ice concentration estimates derived from synthetic aperture radar (SAR) imagery, passive microwave imagery at several frequencies, aerial photography, and spectral photometer data. The comparison is carried out not only to evaluate SAR performance against more established techniques but also to investigate how ice surface conditions, imaging geometry, and choice of algorithm parameters affect estimates made by each sensor.Active and passive microwave sensor estimates of ice concentration derived using similar algorithms show an rms difference of 13 percent. Agreement between each microwave sensor and near-simultaneous aerial photography is approximately the same (14 percent). The availability of high-resolution microwave imagery makes it possible to ascribe the discrepancies in the concentration estimates to variations in ice surface signatures in the scene.

Microwave and physical properties of sea ice in the winter marginal ice zone

NASA Technical Reports Server (NTRS)

Tucker, W. B., III; Perovich, D. K.; Gow, A. J.; Grenfell, T. C.; Onstott, R. G.

1991-01-01

Surface-based active and passive microwave measurements were made in conjunction with ice property measurements for several distinct ice types in the Fram Strait during March and April 1987. Synthesis aperture radar imagery downlinked from an aircraft was used to select study sites. The surface-based radar scattering cross section and emissivity spectra generally support previously inferred qualitative relationships between ice types, exhibiting expected separation between young, first-year and multiyear ice. Gradient ratios, calculated for both active and passive data, appear to allow clear separation of ice types when used jointly. Surface flooding of multiyear floes, resulting from excessive loading and perhaps wave action, causes both active and passive signatures to resemble those of first-year ice. This effect could possibly cause estimates of ice type percentages in the marginal ice zone to be in error when derived from aircraft- or satellite-born sensors.

Breaks in Pavement and Pipes as Indicators of Range-Front Faulting Resulting from the 1989 Loma Prieta Earthquake near the Southwest Margin of the Santa Clara Valley, California

USGS Publications Warehouse

Schmidt, Kevin M.; Ellen, Stephen D.; Haugerud, Ralph A.; Peterson, David M.; Phelps, Geoffery A.

1995-01-01

Damage to pavement and near-surface utility pipes, caused by the October 17, 1989, Loma Prieta earthquake, provide indicators for ground deformation in a 663 km2 area near the southwest margin of the Santa Clara Valley, California. The spatial distribution of 1284 sites of such damage documents the extent and distribution of detectable ground deformation. Damage was concentrated in four zones, three of which are near previously mapped faults. The zone through Los Gatos showed the highest concentration of damage, as well as evidence for pre- and post-earthquake deformation. Damage along the foot of the Santa Cruz Mountains reflected shortening that is consistent with movement along reverse faults in the region and with the hypothesis that tectonic strain is distributed widely across numerous faults in the California Coast Ranges.

Chapter C in Geological Survey research 1967

USGS Publications Warehouse

1967-01-01

Low-grade metamorphic rocks of the blueschist facies grade upward to the sole of a great thrust fault along the eastern margin of the Coast Ranges in northern California and southwestern Oregon. The gradation is defined by three textural zones of increasing reconstitution in metagraywacke, and by two metamorphic mineral zones, lawsonite and pumpellyite. The metagraywacke of textural zones 1 and 2 is clearly Franciscan Formation on the basis of lithology and age, and grades into thoroughly reconstituted rocks of textural zone 3 that herein are named the South Fork Mountain Schist. The blueschist probably formed in a zone of cataclasis and anomalously high water pressures under the thrust fault, rather than in the generally postulated zone of extreme depth of burial. Water in excess of that required to form pumpellyite and lawsonite was available for serpentinization of ultramafic rocks emplaced in the thrust fault.

Reconstructing the Avalon continent: Marginal to inner platform transition in the Cambrian of southern New Brunswick

USGS Publications Warehouse

Landing, E.

1996-01-01

A west to east, marginal to inner Avalonian platform transition, comparable to that in southeast Newfoundland and southern Britain, is present in the Cambrian of southern New Brunswick. The Saint John - Caton's Island - Hanford Brook area lay on the marginal platform, and its thick, uppermost Precambrian - lower Lower Cambrian is unconformably overlain by trilobite-bearing, upper Lower Cambrian. An inner platform remnant is preserved in the Cradle Brook outlier 60 km northeast of Saint John. In contrast to the marginal platform sequences, the Cradle Brook outlier has a very thin lower Lower Cambrian and has middle Lower Cambrian strata (Bonavista Group) not present on the marginal platform. The Cradle Brook Lower Cambrian closely resembles inner platform successions in eastern Massachusetts and Trinity and Placentia bays, southeast Newfoundland. A limestone with Camenella baltica Zone fossils on Cradle Brook seems to be the peritidal limestone cap of the subtrilobitic Lower Cambrian known in Avalonian North America (Fosters Point Formation) and England (Home Farm Member).

Rift migration explains continental margin asymmetry and crustal hyper-extension

PubMed Central

Brune, Sascha; Heine, Christian; Pérez-Gussinyé, Marta; Sobolev, Stephan V.

2014-01-01

When continents break apart, continental crust and lithosphere are thinned until break-up is achieved and an oceanic basin is formed. The most remarkable and least understood structures associated with this process are up to 200 km wide areas of hyper-extended continental crust, which are partitioned between conjugate margins with pronounced asymmetry. Here we show, using high-resolution thermo-mechanical modelling, that hyper-extended crust and margin asymmetry are produced by steady state rift migration. We demonstrate that rift migration is accomplished by sequential, oceanward-younging, upper crustal faults, and is balanced through lower crustal flow. Constraining our model with a new South Atlantic plate reconstruction, we demonstrate that larger extension velocities may account for southward increasing width and asymmetry of these conjugate magma-poor margins. Our model challenges conventional ideas of rifted margin evolution, as it implies that during rift migration large amounts of material are transferred from one side of the rift zone to the other. PMID:24905463

Final Project Report, DE-SC0001280, Characterizing the Combined Roles of Iron and Transverse Mixing on Uranium Bioremediation in Groundwater using Microfluidic Devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finneran, Kevin; Werth, Charles; Strathmann, Timothy

2015-01-10

In situ bioremediation of U(VI) involves amending groundwater with an appropriate electron donor and limiting nutrients to promote biological reduction to the less soluble and mobile U(IV) oxidation state. Groundwater flow is laminar; mixing is controlled by hydrodynamic dispersion. Recent studies indicate that transverse dispersion along plume margins can limit mixing of the amended electron donor and accepter (such as U(VI) in remediation applications). As a result, microbial growth, and subsequently contaminant reaction, may be limited to these transverse mixing zones during bioremediation. The primary objective of this work was to characterize the combined effects of hydrology, geochemistry, and biologymore » on the (bio)remediation of U(VI). Our underlying hypothesis was that U(VI) reaction in groundwater is controlled by transverse mixing with an electron donor along plume margins, and that iron bioavailability in these zones affects U(VI) reduction kinetics and U(IV) re-oxidation. Our specific objectives were to a) quantify reaction kinetics mediated by biological versus geochemical reactions leading to U(VI) reduction and U(IV) re-oxidation, b) understand the influence of bioavailable iron on U(VI) reduction and U(IV) re-oxidation along the transverse mixing zones, c) determine how transverse mixing limitations and the presence of biomass in pores affects these reactions, and d) identify how microbial populations that develop along transverse mixing zones are influenced by the presence of iron and the concentration of electron donor. In the completed work, transverse mixing zones along plume margins were re-created in microfluidic pore networks, referred to as micromodels. We conducted a series of experiments that allowed us to distinguish among the hydraulic, biological, and geochemical mechanisms that contribute to U(VI) reduction, U(IV) re-oxidation, and U(VI) abiotic reaction with the limiting biological nutrient HP042-. This systematic approach may lead to a better understanding of U(VI) remediation, and better strategies for groundwater amendments to maximize remediation efficiency.« less

Macrofaunal colonization across the Indian margin oxygen minimum zone

NASA Astrophysics Data System (ADS)

Levin, L. A.; McGregor, A. L.; Mendoza, G. F.; Woulds, C.; Cross, P.; Witte, U.; Gooday, A. J.; Cowie, G.; Kitazato, H.

2013-11-01

There is a growing need to understand the ability of bathyal assemblages to recover from disturbance and oxygen stress, as human activities and expanding oxygen minimum zones increasingly affect deep continental margins. The effects of a pronounced oxygen minimum zone (OMZ) on slope benthic community structure have been studied on every major upwelling margin; however, little is known about the dynamics or resilience of these benthic populations. To examine the influence of oxygen and phytodetritus on short-term settlement patterns, we conducted colonization experiments at 3 depths on the West Indian continental margin. Four colonization trays were deployed at each depth for 4 days at 542 and 802 m (transect 1-16°58' N) and for 9 days at 817 and 1147 m (transect 2-17°31' N). Oxygen concentrations ranged from 0.9 μM (0.02 mL L-1) at 542 m to 22 μM (0.5 mL L-1) at 1147 m. All trays contained local defaunated sediments; half of the trays at each depth also contained 13C/15N-labeled phytodetritus mixed into the sediments. Sediment cores were collected between 535 m and 1140 m from 2 cross-margin transects for analysis of ambient (source) macrofaunal (>300 μm) densities and composition. Ambient macrofaunal densities ranged from 0 ind m-2 (at 535-542 m) to 7400 ind m-2, with maximum values on both transects at 700-800 m. Macrofaunal colonizer densities ranged from 0 ind m-2 at 542 m, where oxygen was lowest, to average values of 142 ind m-2 at 800 m, and 3074 ind m-2 at 1147 m, where oxygen concentration was highest. These were equal to 4.3 and 151% of the ambient community at 800 m and 1147 m, respectively. Community structure of settlers showed no response to the presence of phytodetritus. Increasing depth and oxygen concentration, however, significantly influenced the community composition and abundance of colonizing macrofauna. Polychaetes constituted 92.4% of the total colonizers, followed by crustaceans (4.2%), mollusks (2.5%), and echinoderms (0.8%). The majority of colonizers were found at 1147 m; 88.5% of these were Capitella sp., although they were rare in the ambient community. Colonists at 800 and 1147 m also included ampharetid, spionid, syllid, lumbrinerid, cirratulid, cossurid and sabellid polychaetes. Consumption of 13C/15N-labeled phytodetritus was observed for macrofaunal foraminifera (too large to be colonizers) at the 542 and 802/817 m sites, and by metazoan macrofauna mainly at the deepest, better oxygenated sites. Calcareous foraminifera (Uvigerina, Hoeglundina sp.), capitellid polychaetes and cumaceans were among the major phytodetritus consumers. These preliminary experiments suggest that bottom-water oxygen concentrations may strongly influence ecosystem services on continental margins, as reflected in rates of colonization by benthos and colonizer processing of carbon following disturbance. They may also provide a window into future patterns of settlement on the continental slope as the world's oxygen minimum zones expand.

Tectonic Evolution of the Izmir Ankara Suture Zone in Northwest Turkey Using Zircon U-Pb Geochronology and Zircon Lu-Hf Isotopic Tracers

NASA Astrophysics Data System (ADS)

Campbell, C.; Taylor, M. H.; Licht, A.; Mueller, M.; Ocakglu, F.; Moeller, A.; Metais, G.; Beard, K. C.

2017-12-01

Detrital zircons from a Cretaceous forearc basin and Tertiary foreland basin located along the Sakarya Zone of the Western Pontides were analyzed to better understand the closure history of the Tethyan oceans. The Variscan Orogeny is characterized by abundant 350-300 Ma U-Pb ages and vertical ɛHf arrays, consistent with a mature magmatic arc that emplaced plutons through a southward growing accretionary margin. An ɛHf pull-up is observed from 300-250 Ma interpreted as rifting of the Intra-Pontide Ocean. The Cimmerian Orogeny is characterized by a 250-230 Ma ɛHf pull-down, followed by a 230-200 Ma magmatic gap consistent with underthrusting of the Karakaya Complex. From 200-120 Ma another magmatic lull is observed. The Alpine Orogeny is characterized by an ɛHf pull-down from 120-85 Ma within Cretaceous forearc sediments and a 100 Ma deviant ɛHf vertical array within Tertiary foreland basin sediments. Minor zircon U-Pb age peaks and contrasting inter-basinal ɛHf evolution are interpreted to represent onset of Andean-style subduction along the southern margin of the Sakarya Zone at 120 Ma followed by crustal thickening until 85 Ma. The deviant 100 Ma ɛHf vertical array within foreland basin detritus is interpreted as initiation of intra-oceanic subduction within the Izmir-Ankara Ocean. An 85-75 Ma ɛHf pull-up from forearc basin sediments is interpreted as slab roll-back along the southern margin of the Sakarya Zone, responsible for final rifting of the Western Black Sea. At 80 Ma, a vertical ɛHf array from Tertiary foreland basin deposits is interpreted to represent synchronous melting of the Tavsanli Zone and intra-oceanic slab break-off. A single 66 Myr pre-collisional grain defines a sharp ɛHf pull-down immediately prior to total arc shut-off, interpreted to represent incipient collision between the Sakarya and Tavsanli zones. A 52 Ma syn-collisional tuff yields minimally intermediate ɛHf values followed by a slight 48 Ma ɛHf pull-down, interpreted as a second episode of slab break-off followed by crustal thickening, a result of renewed underthrusting.

Crustal thinning and exhumation along a fossil magma-poor distal margin preserved in Corsica: A hot rift to drift transition?

NASA Astrophysics Data System (ADS)

Beltrando, Marco; Zibra, Ivan; Montanini, Alessandra; Tribuzio, Riccardo

2013-05-01

Rift-related thinning of continental basement along distal margins is likely achieved through the combined activity of ductile shear zones and brittle faults. While extensional detachments responsible for the latest stages of exhumation are being increasingly recognized, rift-related shear zones have never been sampled in ODP sites and have only rarely been identified in fossil distal margins preserved in orogenic belts. Here we report evidence of the Jurassic multi-stage crustal thinning preserved in the Santa Lucia nappe (Alpine Corsica), where amphibolite facies shearing persisted into the rift to drift transition. In this nappe, Lower Permian meta-gabbros to meta-gabbro-norites of the Mafic Complex are separated from Lower Permian granitoids of the Diorite-Granite Complex by a 100-250 m wide shear zone. Fine-grained syn-kinematic andesine + Mg-hornblende assemblages in meta-tonalites of the Diorite-Granite Complex indicate shearing at T = 710 ± 40 °C at P < 0.5 GPa, followed by deformation at greenschist facies conditions. 40Ar/39Ar step-heating analyses on amphiboles reveal that shearing at amphibolite facies conditions possibly began at the Triassic-Jurassic boundary and persisted until t < 188 Ma, with the Mafic Complex cooling rapidly at the footwall of the Diorite-Granite Complex at ca. 165.4 ± 1.7 Ma. Final exhumation to the basin floor was accommodated by low-angle detachment faulting, responsible for the 1-10 m thick damage zone locally capping the Mafic Complex. The top basement surface is onlapped at a low angle by undeformed Mesozoic sandstone, locally containing clasts of footwall rocks. Existing constraints from the neighboring Corsica ophiolites suggest an age of ca. 165-160 Ma for these final stages of exhumation of the Santa Lucia basement. These results imply that middle to lower crustal rocks can be cooled and exhumed rapidly in the last stages of rifting, when significant crustal thinning is accommodated in less than 5 Myr through the consecutive activity of extensional shear zones and detachment faults. High thermal gradients may delay the switch from ductile shear zone- to detachment-dominated crustal thinning, thus preventing the exhumation of middle and lower crustal rocks until the final stages of rifting.

Palaeozoic and Mesozoic tectonic implications of Central Afghanistan

NASA Astrophysics Data System (ADS)

Sliaupa, Saulius; Motuza, Gediminas

2017-04-01

The field and laboratory studies were carried out in Ghor Province situated in the central part of Afghanistan. It straddles juxtaposition of the Tajik (alternatively, North Afghanistan) and Farah Rod blocks separated by Band-e-Bayan zone. The recent studies indicate that Band-e-Bayan zone represents highly tectonised margin of the Tajik block (Motuza, Sliaupa, 2016). The Band-e-Bayan zone is the most representative in terms of sedimentary record. The subsidence trends and sediment lithologies suggest the passive margin setting during (Cambrian?) Ordovician to earliest Carboniferous times. A change to the foredeep setting is implied in middle Carboniferous through Early Permian; the large-thickness flysh-type sediments were derived from continental island arc provenance, as suggested by chemical composition of mudtstones. This stage can be correlated to the amalgamation of the Gondwana supercontinent. The new passive-margin stage can be inferred in the Band-e-Bayan zone and Tajik blocks in the Late Permian throughout the early Late Triassic that is likely related to breaking apart of Gondwana continent. A collisional event is suggested in latest Triassic, as seen in high-rate subsidence associating with dramatic change in litholgies, occurrence of volcanic rocks and granidoid intrusions. The continental volcanic island arc derived (based on geochemical indices) terrigens prevail at the base of Jurassic that were gradually replaced by carbonate platform in the Middle Jurassic pointing to cessation of the tectonic activity. A new tectonic episode (no deposition; and folding?) took place in the Tajik and Band-e-Bayan zone in Late Jurassic. The geological section of the Farah Rod block, situated to the south, is represented by Jurassic and Cretaceous sediments overlain by sporadic Cenozoic volcanic-sedimentary succession. The lower part of the Mesozoic succession is composed of terrigenic sediments giving way to upper Lower Cretaceous shallow water carbonates implying low tectonic regime. There was a break in sedimentation during the upper Cretaceous that is likely related to the Alpine orogenic event. It associated with some Upper Cretaceous magmatic activity (Debon et al., 1987). This event is reflected in the sedimentation pattern in the adjacent Band-e-Bayan zone and Tadjick block. The lower part of the Upper Cretaceous succession is composed of reddish terrigenic sediments. They are overlain by uppermost Cretaceous (and Danian) shallow marine sediments implying establishment of quiet tectonic conditions.

Sulfur cycling in an iron oxide-dominated, dynamic marine depositional system: The Argentine continental margin

NASA Astrophysics Data System (ADS)

Riedinger, Natascha; Brunner, Benjamin; Krastel, Sebastian; Arnold, Gail L.; Wehrmann, Laura M.; Formolo, Michael J.; Beck, Antje; Bates, Steven M.; Henkel, Susann; Kasten, Sabine; Lyons, Timothy W.

2017-05-01

The interplay between sediment deposition patterns, organic matter type and the quantity and quality of reactive mineral phases determines the accumulation, speciation and isotope composition of pore water and solid phase sulfur constituents in marine sediments. Here, we present the sulfur geochemistry of siliciclastic sediments from two sites along the Argentine continental slope—a system characterized by dynamic deposition and reworking, which result in non-steady state conditions. The two investigated sites have different depositional histories but have in common that reactive iron phases are abundant and that organic matter is refractory—conditions that result in low organoclastic sulfate reduction rates. Deposition of reworked, isotopically light pyrite and sulfurized organic matter appear to be important contributors to the sulfur inventory, with only minor addition of pyrite from organoclastic sulfate reduction above the sulfate-methane transition (SMT). Pore-water sulfide is limited to a narrow zone at the SMT. The core of that zone is dominated by pyrite accumulation. Iron monosulfide and elemental sulfur accumulate above and below this zone. Iron monosulfide precipitation is driven by the reaction of low amounts of hydrogen sulfide with ferrous iron and is in competition with the oxidation of sulfide by iron (oxyhydr)oxides to form elemental sulfur. The intervals marked by precipitation of intermediate sulfur phases at the margin of the zone with free sulfide are bordered by two distinct peaks in total organic sulfur. Organic matter sulfurization appears to precede pyrite formation in the iron-dominated margins of the sulfide zone, potentially linked to the presence of polysulfides formed by reaction between dissolved sulfide and elemental sulfur. Thus, SMTs can be hotspots for organic matter sulfurization in sulfide-limited, reactive iron-rich marine sedimentary systems. Furthermore, existence of elemental sulfur and iron monosulfide phases meters below the SMT demonstrates that in sulfide-limited systems metastable sulfur constituents are not readily converted to pyrite but can be buried to deeper sediment depths. Our data show that in non-steady state systems, redox zones do not occur in sequence but can reappear or proceed in inverse sequence throughout the sediment column, causing similar mineral alteration processes to occur at the same time at different sediment depths.

A plutonic view of explosive volcanism: the shatter zone of the Cadillac Mountain granite, Maine

NASA Astrophysics Data System (ADS)

Wiebe, R.

2013-12-01

The Silurian Cadillac Mountain granite (CMG) is about 15 km in diameter. It is underlain on its deeper western margin by layered gabbro-diorite (GD) up to 3 km thick and on its eastern and southern margins by an intrusive breccia (the 'shatter zone' (SZ)), up to 1 km wide. Coeval rhyolite tuffs, ignimbrites and lavas occur near the southern margin of the granite. The more shallow eastern part of the SZ can be divided into three zones: (SZA) An outer zone against country rock (CR) consists of strongly broken up, deformed sedimentary rocks and angular blocks of diabase invaded by thin irregular veins of aphanitic felsite. All CR fragments are tightly packed with less than ~ 15% matrix, which coarsens inward to vfg quartz, feldspar and biotite. (SZB) A central zone contains abundant sedimentary and scarce rhyolite blocks (typically < 1 m) and larger diabase blocks (from < 1 m to 10s of meters). This zone has 20 to 60% fg to mg matrix with quartz, two feldspars, biotite and abundant pieces of CR down to a few mm. It typically has a strong flow fabric around CR blocks. (SZC) The inner zone has only large (10-80 m) blocks of sedimentary rock, diabase and rhyolite (flows and ignimbrite). The mg granitic matrix (>60%) has blocky hypersolvus feldspar, interstitial to equant quartz, Fe-cpx, Fe-hornblende, two oxides and scarce fayalite. Feldspar in this zone consistently has a sequence of zones consisting of: (1) a homogeneous core of ~ An10Ab80Or10, (2) a transition up to 1 mm wide with 10-15 Or-Ab oscillations (e.g. from Or10 to Or30), each from 20 to 100 microns in width, and (3) a nearly homogeneous rim of variable width averaging about An3Ab70Or27. The occurrence of crystals with such distinctive zoning over such a great distance (18 km) suggests that the zoning was produced by an intensive parameter and not by magma mixing. Because the crystals are restricted to the SZ matrix, processes that produced the shatter zone probably also influenced feldspar zoning. Analysis of clast size distribution of CR fragments in SZA and SZB suggests an extremely high-energy environment consistent with a pyroclastic eruption from the CMG magma chamber (Roy et al. 2012). If such an eruption did occur, one expected effect would be episodic, sudden drops in pressure during degassing and eruptive events. Since the lower part of the chamber was apparently relatively dry (hypersolvus alkali feldspar with ternary feldspar occurs in CMG immediately above the GD), the drop in pressure would lower H2O activity so that the Ab-rich loop of the alkali feldspar phase diagram would shift to higher T, causing the melt to fall below the liquidus and shift the equilibrium solid feldspar to higher Or values. This matches the initial oscillatory zone to higher Or on the homogeneous cores. Because the SZ terminates at the top of the GD, it is likely that mafic input contributed to the eruption. The large inward increase in the crystallization T of the matrix from SZA to SZC probably records initial escape of a cooler felsic cap and upwelling of deep, hot hypersolvus magma along with partial collapse of the chamber roof.

Comparative analysis of glucagonergic cells, glia and the circumferential marginal zone in the reptilian retina

PubMed Central

Todd, Levi; Suarez, Lilianna; Squires, Natalie; Zelinka, Christopher Paul; Gribbins, Kevin; Fischer, Andy J.

2015-01-01

Retinal progenitors in the circumferential margin zone (CMZ) and Müller glia-derived progenitors have been well-described in the eyes of fish, amphibians and birds. However, there is no information regarding a CMZ and the nature of retinal glia in species phylogenetically bridging amphibians and birds. Thus, the purpose of this study was to examine the retinal glia and investigate whether a CMZ is present in the eyes of reptilian species. We used immuno-histochemical analyses to study retinal glia, neurons that could influence CMZ-progenitors, the retinal margin, and non-pigmented epithelium (NPE) of ciliary body of garter snakes, queen snakes, anole lizards, snapping turtles, and painted turtles. We compare our observations in reptile eyes to the CMZ and glia of fish, amphibians and birds. In all species, Sox9, Pax6 and the glucocorticoid receptor are expressed by Müller glia and cells at the retinal margin. However, proliferating cells were found only in the CMZ of turtles, but not in the eyes of anoles and snakes. Similar to eyes of chickens, the retinal margin in turtles contains accumulations of GLP1/glucagonergic neurites. We find that filamentous proteins, vimentin and GFAP, are expressed by Müller glia, but have different patterns of sub-cellular localization in the different species of reptiles. We provide evidence that the reptile retina may contain Non-astrocytic Inner Retinal Glial (NIRG) cells, similar to those described in the avian retina. We conclude that the retinal glia, glucagonergic neurons and CMZ of turtles appears to be the most similar to that of fish, amphibians and birds. PMID:26053997

Mantle exhumation at magma-poor rifted margin: a competition between frictional shear zones and thermally weakened necking domains. Consequences on time of breakup at Galicia/Newfoundland margins.

NASA Astrophysics Data System (ADS)

Theunissen, T.; Huismans, R. S.

2017-12-01

Here we present a new analysis and interpretation of basement topography of the transitional domain from continental to oceanic crust along the conjugate margin sections SCREETCH-1 (Newfoundland) and WE-1/ISE-1 (Galicia Bank). The absence of significant syn-rift magmatism in this area allows using 2-D thermo-mechanical modelling to understand the formation of the distal margin and exhumed mantle. We show that plastic strain weakening of the exhumed mantle is required to explain observations on basement morphology, and detachment faulting. Our models predict that the evolution of detachment faulting within the transitional domain depends on the degree of frictional-plastic strain-weakening and varies from a single unique steady state asymmetric low angle detachment fault for large degree of strain weakening to multiple out-of-sequence forming detachments with or without dip reversal for lower amounts of strain-weakening. The model behaviour is a consequence of the competition between weak frictional-plastic shear zones and the thermally weakened necking domain in the footwall. The forward models reproduce elevations, wavelength of exhumed mantle ridges for a narrow range of rift velocitiesbetween 10 and 15 mm/yr and considering the increasing thermal conductivity of peridotites at shallow depth. This causes an efficient cooling of the footwall that has then enough strength to support high topography. The forward models also predict that the peridotite ridge is the breakaway of a second detachment fault that dates the crustal breakup and that rocks on top of the peridotite ridge have experimented a fast cooling (< 2 Ma). We use predictions from these forward models to discuss time of breakup and the position of the first steady state oceanic ridge at Galicia/Newfounlandconjugate margins.

Neogene collision and deformation of convergent margins along the backbone of the Americas

USGS Publications Warehouse

von Huene, Roland E.; Ranero, C.R.

2009-01-01

Along Pacific convergent margins of the Americas, high-standing relief on the subducting oceanic plate "collides" with continental slopes and subducts. Features common to many collisions are uplift of the continental margin, accelerated seafloor erosion, accelerated basal subduction erosion, a flat slab, and a lack of active volcanism. Each collision along America's margins has exceptions to a single explanation. Subduction of an ???600 km segment of the Yakutat terrane is associated with >5000-m-high coastal mountains. The terrane may currently be adding its unsubducted mass to the continent by a seaward jump of the deformation front and could be a model for docking of terranes in the past. Cocos Ridge subduction is associated with >3000-m-high mountains, but its shallow subduction zone is not followed by a flat slab. The entry point of the Nazca and Juan Fernandez Ridges into the subduction zone has migrated southward along the South American margin and the adjacent coast without unusually high mountains. The Nazca Ridge and Juan Fernandez Ridges are not actively spreading but the Chile Rise collision is a triple junction. These collisions form barriers to trench sediment transport and separate accreting from eroding segments of the frontal prism. They also occur at the separation of a flat slab from a steeply dipping one. At a smaller scale, the subduction of seamounts and lesser ridges causes temporary surface uplift as long as they remain attached to the subducting plate. Off Costa Rica, these features remain attached beneath the continental shelf. They illustrate, at a small scale, the processes of collision. ?? 2009 The Geological Society of America. All rights reserved.

Who’s on top? SST proxy comparison from the Peru Margin Upwelling System

NASA Astrophysics Data System (ADS)

Chazen, C.; Herbert, T.; Altabet, M. A.

2009-12-01

The Peru Margin upwelling region is situated at the interface between the poleward Peru Undercurrent and the equatorward Peru Coastal current. Strong coastal winds force cold, nutrient-rich thermocline waters to the surface. Sea surface temperatures in this region fluctuate sub-annually with changes in the position of the Intertropical convergence zone (ITCZ) and sub-decadally with modifications in the strength of Walker Circulation. In contrast, the temperature of the Peru Margin thermocline is stable, isolated from surface winds and slow to respond to major perturbations in surface temperature. Using high resolution sampling (6-7 year) across an annually laminated sediment core from the heart of the Peru Margin upwelling system (15°S) we explore how Uk’37 temperatures compare with TEX86 temperatures across a 200-year interval in the Mid-late Holocene. Mean late Holocene Uk’37 temperatures, extracted from a high sedimentation rate core from the Peru Margin are similar to modern mean annual sea surface temperatures at 15°S. Multi-decadal-scale (50-100 year) Uk’37 temperature fluctuations oscillate about the mean by 1.5°C. These rapid temperature changes are coherent with fluctuations in surface productivity (C37total and Biogenic Silica) in addition to sub-surface denitrification (δ15N). In contrast, TEX86 temperatures derived from identical samples exhibit colder temperatures than modern mean annual conditions and virtually no temperature fluctuation. We posit that TEX86 values are recording temperatures below the photic zone near the mix-layer-thermocline boundary and may, on longer timescales provide invaluable information about thermocline temperature. With this interpretation in mind, we present a TEX86-based long-term thermocline reconstruction over the Holocene.

Distribution and depth of bottom-simulating reflectors in the Nankai subduction margin.

PubMed

Ohde, Akihiro; Otsuka, Hironori; Kioka, Arata; Ashi, Juichiro

2018-01-01

Surface heat flow has been observed to be highly variable in the Nankai subduction margin. This study presents an investigation of local anomalies in surface heat flows on the undulating seafloor in the Nankai subduction margin. We estimate the heat flows from bottom-simulating reflectors (BSRs) marking the lower boundaries of the methane hydrate stability zone and evaluate topographic effects on heat flow via two-dimensional thermal modeling. BSRs have been used to estimate heat flows based on the known stability characteristics of methane hydrates under low-temperature and high-pressure conditions. First, we generate an extensive map of the distribution and subseafloor depths of the BSRs in the Nankai subduction margin. We confirm that BSRs exist at the toe of the accretionary prism and the trough floor of the offshore Tokai region, where BSRs had previously been thought to be absent. Second, we calculate the BSR-derived heat flow and evaluate the associated errors. We conclude that the total uncertainty of the BSR-derived heat flow should be within 25%, considering allowable ranges in the P-wave velocity, which influences the time-to-depth conversion of the BSR position in seismic images, the resultant geothermal gradient, and thermal resistance. Finally, we model a two-dimensional thermal structure by comparing the temperatures at the observed BSR depths with the calculated temperatures at the same depths. The thermal modeling reveals that most local variations in BSR depth over the undulating seafloor can be explained by topographic effects. Those areas that cannot be explained by topographic effects can be mainly attributed to advective fluid flow, regional rapid sedimentation, or erosion. Our spatial distribution of heat flow data provides indispensable basic data for numerical studies of subduction zone modeling to evaluate margin parallel age dependencies of subducting plates.

The geology of the Inconsolable Range, east-central Sierra Nevada, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hathaway, G.M; Reed, W.E.

1993-04-01

Detailed mapping of the Inconsolable Range in the east-central Sierra Nevada reveals a structurally and lithologically complex region of multi-phase intrusions. Some plutons are compositionally-zoned [e.g., Inconsolable (100 Ma) and Lamarck (90 Ma)]; others may be the result of magma mixing. Intrusive borders vary from brittle to ductile and sharp to gradational, and are bounded by contact aureoles of varying metamorphic grade. A shear zone (Long Lake shear zone -- LLSZ) bounds the western margin of the Inconsolable Range for 8 km; this is truncated in the south by the Cretaceous Lamarck intrusive suite, and is tectonically overlain in themore » north by the Bishop Creek Pendant (Ordovician ). The LLSZ is a complex zone of interleaved septa of biotite schists, orthogneisses, aplitic screens, and calc-silicate gneisses approximately 500 to 800 m wide. Preliminary interpretation suggests that the LLSZ is the sheared remnant of a Triassic-Jurassic igneous terrane complete with metasedimentary pendants. Juxtaposition of greenschist facies meta-sedimentary rocks of the Chocolate Peak klippe over highly deformed amphibolite grade meta-igneous rocks of the LLSZ postdates movement along the LLSZ. Metamorphic grades suggest that deeper structural levels are exposed within the LLSZ near its southern terminus. Twenty plutonic lithologies have been mapped and informally named (e.g., Spotted biotite quartz diorite), including 3 compositionally-zoned plutons. Zonation within the Lamarck, Inconsolable, and Spotted intrusions are the result of multiple emplacement events into partially crystallized host plutons. Along the eastern border of the Lamarck intrusive suite field evidence indicates four separate intrusive events. The Inconsolable body is a compositionally-zoned biotite, clinopyroxene, quartz diorite with irregular granodiorite margins. The base of the Spotted intrusion appears to have been magmatically eroded by a pulse of the younger Lamarck intrusion.« less

The role of the oceanic oxygen minima in generating biodiversity in the deep sea

NASA Astrophysics Data System (ADS)

Rogers, Alex D.

2000-01-01

Many studies on the deep-sea benthic biota have shown that the most species-rich areas lie on the continental margins between 500 and 2500 m, which coincides with the present oxygen-minimum in the world's oceans. Some species have adapted to hypoxic conditions in oxygen-minimum zones, and some can even fulfil all their energy requirements through anaerobic metabolism for at least short periods of time. It is, however, apparent that the geographic and vertical distribution of many species is restricted by the presence of oxygen-minimum zones. Historically, cycles of global warming and cooling have led to periods of expansion and contraction of oxygen-minimum layers throughout the world's oceans. Such shifts in the global distribution of oxygen-minimum zones have presented many opportunities for allopatric speciation in organisms inhabiting slope habitats associated with continental margins, oceanic islands and seamounts. On a smaller scale, oxygen-minimum zones can be seen today as providing a barrier to gene-flow between allopatric populations. Recent studies of the Arabian Sea and in other regions of upwelling also have shown that the presence of an oxygen-minimum layer creates a strong vertical gradient in physical and biological parameters. The reduced utilisation of the downward flux of organic material in the oxygen-minimum zone results in an abundant supply of food for organisms immediately below it. The occupation of this area by species exploiting abundant food supplies may lead to strong vertical gradients in selective pressures for optimal rates of growth, modes of reproduction and development and in other aspects of species biology. The presence of such strong selective gradients may have led to an increase in habitat specialisation in the lower reaches of oxygen-minimum zones and an increased rate of speciation.

Modeling Mantle Shear Zones, Melt Focusing and Stagnation - Are Non Volcanic Margins Really Magma Poor?

NASA Astrophysics Data System (ADS)

Lavier, L. L.; Muntener, O.

2011-12-01

Mantle peridotites from ocean-continent transition zones (OCT's) and ultraslow spreading ridges question the commonly held assumption of a simple link between mantle melting and MORB. 'Ancient' and partly refertilized mantle in rifts and ridges illustrates the distribution of the scale of upper mantle heterogeneity even on a local scale. Upwelling of partial melts that enter the conductive lithospheric mantle inevitably leads to freezing of the melt and metasomatized lithosphere. Field data and petrology demonstrates that ancient, thermally undisturbed, pyroxenite-veined subcontinental mantle blobs formed parts of the ocean floor next to thinned continental crust. Similar heterogeneity might be created in the oceanic lithosphere where the thermal boundary layer (TBM) is thick and veined with metasomatic assemblages. This cold, ancient, 'subcontinental domain' is separated by ductile shear zones (or some other form of permeability barriers) from an infiltrated ('hot') domain dominated by refertilized spinel and/or plagioclase peridotite. The footwall of these mantle shear zones display complex refertilization processes and high-temperature deformation. We present numerical models that illustrate the complex interplay of km-scale refertilization with active deformation and melt focusing on top of the mantle. Melt lubricated shear zones focus melt flow in shear fractures (melt bands) occurring along grain boundaries. Continuous uplift and cooling leads to crystallization, and crystal plastic deformation prevails in the subsolidus state. Below 800oC if water is present deformation by shearing of phyllosilicates may become prevalent. We develop physical boundary conditions for which stagnant melt beneath a permeability barrier remains trapped rather than being extracted to the surface via melt-filled fractures. We explore the parameter space for fracturing and drainage and development of anastomozing impermeable shear zones. Our models might be useful to constrain the conditions and enigmatic development of magma-poor and magma rich margins.

Kinematics of syn- and post-exhumational shear zones at Lago di Cignana (Western Alps, Italy): constraints on the exhumation of Zermatt-Saas (ultra)high-pressure rocks and deformation along the Combin Fault and Dent Blanche Basal Thrust

NASA Astrophysics Data System (ADS)

Kirst, Frederik; Leiss, Bernd

2017-01-01

Kinematic analyses of shear zones at Lago di Cignana in the Italian Western Alps were used to constrain the structural evolution of units from the Piemont-Ligurian oceanic realm (Zermatt-Saas and Combin zones) and the Adriatic continental margin (Dent Blanche nappe) during Palaeogene syn- and post-exhumational deformation. Exhumation of Zermatt-Saas (U)HP rocks to approximately lower crustal levels at ca. 39 Ma occurred during normal-sense top-(S)E shearing under epidote-amphibolite-facies conditions. Juxtaposition with the overlying Combin zone along the Combin Fault at mid-crustal levels occurred during greenschist-facies normal-sense top-SE shearing at ca. 38 Ma. The scarcity of top-SE kinematic indicators in the hanging wall of the Combin Fault probably resulted from strain localization along the uppermost Zermatt-Saas zone and obliteration by subsequent deformation. A phase of dominant pure shear deformation around 35 Ma affected units in the direct footwall and hanging wall of the Combin Fault. It is interpreted to reflect NW-SE crustal elongation during updoming of the nappe stack as a result of underthrusting of European continental margin units and the onset of continental collision. This phase was partly accompanied and followed by ductile bulk top-NW shearing, especially at higher structural levels, which transitioned into semi-ductile to brittle normal-sense top-NW deformation due to Vanzone phase folding from ca. 32 Ma onwards. Our structural observations suggest that syn-exhumational deformation is partly preserved within units and shear zones exposed at Lago di Cignana but also that the Combin Fault and Dent Blanche Basal Thrust experienced significant post-exhumational deformation reworking and overprinting earlier structures.

3D dynamics of crustal deformation driven by oblique subduction: Northern and Central Andes

NASA Astrophysics Data System (ADS)

Schütt, Jorina M.; Whipp, David M., Jr.

2017-04-01

The geometry and relative motion of colliding plates will affect how and where they deform. In oblique subduction systems, factors such as the dip angle of the subducting plate and the convergence obliquity, as well as the presence of weak zones in the overriding plate, all influence how oblique convergence is partitioned onto various fault systems in the overriding plate. The partitioning of strain into margin-normal slip on the plate-bounding fault and horizontal shearing on a strike-slip system parallel to the margin is mainly controlled by the margin-parallel shear forces acting on the plate interface and the strength of the continental crust. While these plate interface forces are influenced by the dip angle of the subducting plate (i.e., the length of plate interface in the frictional domain) and the obliquity angle between the normal to the plate margin and the plate convergence vector, the strength of the continental crust in the upper plate is strongly affected by the presence or absence of weak zones such as regions of arc volcanism, pre-existing fault systems, or boundaries of stronger crustal blocks. In order to investigate which of these factors are most important in controlling how the overriding continental plate deforms, we compare results of lithospheric-scale 3D numerical geodynamic experiments from two regions in the north-central Andes: the Northern Volcanic Zone (NVZ; 5°N - 3°S) and adjacent Peruvian Flat Slab Segment (PFSS; 3°S -14°S). The NVZ is characterized by a 35° subduction dip angle with an obliquity angle of about 40°, extensive volcanism and significant strain partitioning in the continental crust. In contrast, the PFSS is characterized by flat subduction (the slab flattens beneath the continent at around 100 km depth for several hundred kilometers), an obliquity angle of about 20°, no volcanism and minimal strain partitioning. The plate geometry and convergence obliquity for these regions are incorporated in 3D (1600 x 1600 x 160 km) numerical experiments of oceanic subduction beneath a continent, focusing on the conditions under which strain partitioning occurs in the continental plate. In addition to different slab geometries and obliquity angles, we consider the effect of a continental crustal of uniform strength (friction angle Φ=15^°) versus one including a weak zone in the continental crust (Φ=4^°) that runs parallel to the margin. Results of our experiments show that the obliquity angle has the largest effect on initiating strain partitioning, as expected based on strain partitioning theory, but strain partitioning is clearly enhanced by the presence of a continental weakness. Margin-parallel mass transport velocities in the continental sliver are similar to the values observed in the NVZ (about 1 cm/year) in models with a continental weakness and twice as high as those without. In addition, a shallower subduction angle results in formation of a wider continental sliver. Based upon our results, the lack of strain partitioning observed in the PFSS results from both a low convergence obliquity and lack of a weak zone in the continent, even though the shallow subduction should make strain partitioning more favorable.

Interpretation of shallow crustal structure of the Imperial Valley, California, from seismic reflection profiles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Severson, L.K.

1987-05-01

Eight seismic reflection profiles (285 km total length) from the Imperial Valley, California, were provided to CALCRUST for reprocessing and interpretation. Two profiles were located along the western margin of the valley, five profiles were situated along the eastern margin and one traversed the deepest portion of the basin. These data reveal that the central basin contains a wedge of highly faulted sediments that thins to the east. Most of the faulting is strike-slip but there is evidence for block rotations on the scale of 5 to 10 kilometers within the Brawley Seismic Zone. These lines provide insight into themore » nature of the east and west edges of the Imperial Valley. The basement at the northwestern margin of the valley, to the north of the Superstition Hills, has been normal-faulted and blocks of basement material have ''calved'' into the trough. A blanket of sediments has been deposited on this margin. To the south of the Superstition Hills and Superstition Mountain, the top of the basement is a detachment surface that dips gently into the basin. This margin is also covered by a thick sequence sediments. The basement of the eastern margin consists of metamorphic rocks of the upper plate of the Chocolate Mountain Thrust system underlain by the Orocopia Schist. These rocks dip to the southeast and extend westward to the Sand Hills Fault but do not appear to cross it. Thus, the Sand Hills Fault is interpreted to be the southern extension of the San Andreas Fault. North of the Sand Hills Fault the East Highline Canal seismicity lineament is associated with a strike-slip fault and is probably linked to the Sand Hills Fault. Six geothermal areas crossed by these lines, in agreement with previous studies of geothermal reservoirs, are associated with ''faded'' zones, Bouguer gravity and heat flow maxima, and with higher seismic velocities than surrounding terranes.« less

Primary Hepatic Marginal Zone Lymphoma in a Patient with Chronic Hepatitis C.

PubMed

Gherlan, George S; Stoia, Razvan; Enyedi, Mihaly; Dobrea, Camelia; Calistru, Petre I

2016-09-01

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a low-grade malignant lymphoma that appears frequently in the stomach, but other sites can also be involved: the intestinal tract, lungs, head, neck, skin, thyroid, breasts and liver. Recently, epidemiological evidences support the idea that there is an association between hepatitis C and B-cell non-Hodgkin lymphomas (that include MALT as a subtype). Primary non-Hodgkin lymphomas confi ned only to the liver are very rare (only 0.016% of all cases of all non-Hodgkin's lymphomas) and MALT is not the most frequent type. We present the case of a male patient, age 62, known with chronic hepatitis C, previously relapser a" er a 72 week treatment with peg-interferon alfa and ribavirin that was diagnosed at three years a" er the relapse with multiple focal liver lesions. One of the tumors was surgically removed and the histological exam performed demonstrated an extranodal marginal zone lymphoma with small B-cell with plasmacytoid diff erentiation confi ned only to the liver. Direct acting antiviral (DAA) therapy was started, but the virologic clearance was not obtained by week 10, leading to a change of DAA regimen at week 12. The antiviral therapy was continued until week 24. Imaging showed an increase in number and size of the focal lesions until week 12. At week 12 chemo- and immune-therapy was started with bendamustine and rituximab. A" erwards the evolution was favorable, the patient being now in complete remission and with undetectable viral load.

Quantifying the Evolution of Melt Ponds in the Marginal Ice Zone Using High Resolution Optical Imagery and Neural Networks

NASA Astrophysics Data System (ADS)

Ortiz, M.; Pinales, J. C.; Graber, H. C.; Wilkinson, J.; Lund, B.

2016-02-01

Melt ponds on sea ice play a significant and complex role on the thermodynamics in the Marginal Ice Zone (MIZ). Ponding reduces the sea ice's ability to reflect sunlight, and in consequence, exacerbates the albedo positive feedback cycle. In order to understand how melt ponds work and their effect on the heat uptake of sea ice, we must quantify ponds through their seasonal evolution first. A semi-supervised neural network three-class learning scheme using a gradient descent with momentum and adaptive learning rate backpropagation function is applied to classify melt ponds/melt areas in the Beaufort Sea region. The network uses high resolution panchromatic satellite images from the MEDEA program, which are collocated with autonomous platform arrays from the Marginal Ice Zone Program, including ice mass-balance buoys, arctic weather stations and wave buoys. The goal of the study is to capture the spatial variation of melt onset and freeze-up of the ponds within the MIZ, and gather ponding statistics such as size and concentration. The innovation of this work comes from training the neural network as the melt ponds evolve over time; making the machine learning algorithm time-dependent, which has not been previously done. We will achieve this by analyzing the image histograms through quantification of the minima and maxima intensity changes as well as linking textural variation information of the imagery. We will compare the evolution of the melt ponds against several different array sites on the sea ice to explore if there are spatial differences among the separated platforms in the MIZ.

Anomalous heat flow belt along the continental margin of Brazil

NASA Astrophysics Data System (ADS)

Hamza, Valiya M.; Vieira, Fabio P.; Silva, Raquel T. A.

2018-01-01

A comprehensive analysis of thermal gradient and heat flow data was carried out for sedimentary basins situated in the continental margin of Brazil (CMB). The results point to the existence of a narrow belt within CMB, where temperature gradients are higher than 30 °C/km and the heat flow is in excess of 70 mW/m2. This anomalous geothermal belt is confined between zones of relatively low to normal heat flow in the adjacent continental and oceanic regions. The width of the belt is somewhat variable, but most of it falls within the range of 100-300 km. The spatial extent is relatively large in the southern (in the basins of Pelotas, Santos and Campos) and northern (in the basins of Potiguar and Ceará) parts, when compared with those in the central parts (in the basins of South Bahia, Sergipe and Alagoas). The characteristics of heat flow anomalies appear to be compatible with those produced by thermal sources at depths in the lower crust. Hence, magma emplacement at the transition zone between lower crust and upper mantle is considered the likely mechanism producing such anomalies. Seismicity within the belt is relatively weak, with focal depths less than 10 km for most of the events. Such observations imply that "tectonic bonding" between continental and oceanic segments, at the transition zone of CMB, is relatively weak. Hence, it is proposed that passive margins like CMB be considered as constituting a type of plate boundary that is aseismic at sub-crustal levels, but allows for escape of significant amounts of earth's internal heat at shallow depths.

Dislocation models of interseismic deformation in the western United States

USGS Publications Warehouse

Pollitz, F.F.; McCrory, P.; Svarc, J.; Murray, J.

2008-01-01

The GPS-derived crustal velocity field of the western United States is used to construct dislocation models in a viscoelastic medium of interseismic crustal deformation. The interseismic velocity field is constrained by 1052 GPS velocity vectors spanning the ???2500-km-long plate boundary zone adjacent to the San Andreas fault and Cascadia subduction zone and extending ???1000 km into the plate interior. The GPS data set is compiled from U.S. Geological Survey campaign data, Plate Boundary Observatory data, and the Western U.S. Cordillera velocity field of Bennett et al. (1999). In the context of viscoelastic cycle models of postearthquake deformation, the interseismic velocity field is modeled with a combination of earthquake sources on ???100 known faults plus broadly distributed sources. Models that best explain the observed interseismic velocity field include the contributions of viscoelastic relaxation from faulting near the major plate margins, viscoelastic relaxation from distributed faulting in the plate interior, as well as lateral variations in depth-averaged rigidity in the elastic lithosphere. Resulting rigidity variations are consistent with reduced effective elastic plate thickness in a zone a few tens of kilometers wide surrounding the San Andreas fault (SAF) system. Primary deformation characteristics are captured along the entire SAF system, Eastern California Shear Zone, Walker Lane, the Mendocino triple junction, the Cascadia margin, and the plate interior up to ???1000 km from the major plate boundaries.

Impact of damming on the Chironomidae of the upper zone of a tropical run-of-the-river reservoir.

PubMed

Brandimarte, A L; Anaya, M; Shimizu, G Y

2016-06-01

We examined the effects of the Mogi-Guaçu river damming (São Paulo State, Brazil) on the Chironomidae fauna. Pre, during, and post-filling sampling was carried out in the main channel and margins of one site in the upper zone of the reservoir, using a modified Petersen grab (325 cm2). We evaluated the total, subfamily, and tribe densities and also their relative abundance. Analysis of genera included densities, relative abundance, richness, and dominance. The Rosso's ecological value index (EVI) determined the ecological importance of each genus. There was a tendency of decrease of the total Chironomidae density, increase in the percentage of Chironomini, and decrease in densities and percentages of Orthocladiinae and Tanytarsini. These changes in percentage were respectively related to Polypedilum, Lopescladius, and Rheotanytarsus, the genera with the highest EVI values. After-filling richness was lower in the margins and dominance of genera did not change significantly. Chironomidae in the margins was more sensitive to damming than in the main channel. This difference in sensibility sustains the use of Chironomidae as bioindicators. Damming impact was indicated by the reduction of both genera richness in the margins and relative abundance of groups typical of faster waters. The results have highlighted the need for multi-habitat analysis combined with a before-after sampling approach in the environmental impact studies concerning the damming impact on the benthic fauna.

Decadal to centennial oscillations in the upper and lower boundaries of the San Diego, California margin Oxygen Minimum Zone

NASA Astrophysics Data System (ADS)

Myhre, S. E.; Hill, T. M.; Frieder, C.; Grupe, B.

2016-02-01

Here we present two new marine sediment archives from the continental margin of San Diego, California, USA, which record decadal to centennial oscillations in the hydrographic structure of the Eastern Pacific Oxygen Minimum Zone (OMZ). The two cores, located at 528 and 1,180 m water depth, record oceanographic history across overlapping timescales. Biotic communities, including Foraminifera, Echinodermata, Brachiopoda, Mollusca and Ostrocoda, were examined in subsurface (>10 cm sediment core depth) samples. Chronologies for both cores were developed with reservoir-corrected 14C dates of mixed planktonic Foraminifera and linearly interpolated sedimentation rates. Sediment ages for the cores range from 400-1,800 years before present. Indices of foraminiferal community density, diversity and evenness are applied as biotic proxies to track the intensification of the continental margin OMZ. Biotic communities at the shallower site reveal multi-decadal to centennial timescales of OMZ intensification, whereas the deeper site exhibits decadal to multi-decadal scales of hydrographic variability. Hypoxia-associated foraminiferal genera Uvigerina and Bolivina were compositionally dominant during intervals of peak foraminiferal density. Invertebrate assemblages often co-occurred across taxa groups, and thereby provide a broad trophic context for interpreting changes in the margin seafloor. Variability in the advection of Pacific Equatorial Water may mechanistically contribute to this described hydrographic variability. This investigation reconstructs historical timescales of OMZ intensification, seafloor ecological variability, and synchrony between open-ocean processes and regional climate.

Deformation and seismicity associated with continental rift zones propagating toward continental margins

NASA Astrophysics Data System (ADS)

Lyakhovsky, V.; Segev, A.; Schattner, U.; Weinberger, R.

2012-01-01

We study the propagation of a continental rift and its interaction with a continental margin utilizing a 3-D lithospheric model with a seismogenic crust governed by a damage rheology. A long-standing problem in rift-mechanics, known as thetectonic force paradox, is that the magnitude of the tectonic forces required for rifting are not large enough in the absence of basaltic magmatism. Our modeling results demonstrate that under moderate rift-driving tectonic forces the rift propagation is feasible even in the absence of magmatism. This is due to gradual weakening and "long-term memory" of fractured rocks that lead to a significantly lower yielding stress than that of the surrounding intact rocks. We show that the style, rate and the associated seismicity pattern of the rift zone formation in the continental lithosphere depend not only on the applied tectonic forces, but also on the rate of healing. Accounting for the memory effect provides a feasible solution for thetectonic force paradox. Our modeling results also demonstrate how the lithosphere structure affects the geometry of the propagating rift system toward a continental margin. Thinning of the crystalline crust leads to a decrease in the propagation rate and possibly to rift termination across the margin. In such a case, a new fault system is created perpendicular to the direction of the rift propagation. These results reveal that the local lithosphere structure is one of the key factors controlling the geometry of the evolving rift system and seismicity pattern.

Sailing for stretched lithosphere

NASA Astrophysics Data System (ADS)

2008-07-01

Having managed to get themselves and all their instruments on board a ship not too far away from an imminent war zone, Jenny Collier and colleagues enjoyed the serenity of life at sea as they investigated the rifted continental margin of India.

Apatite fission-track thermochronometric constraints on the exhumation and evolution of the southeastern Indian (Tamil Nadu) passive margin and the role of structural inheritance

NASA Astrophysics Data System (ADS)

De Grave, Johan; Glorie, Stijn; Singh, Tejpal; Van Ranst, Gerben; Nachtergaele, Simon

2017-04-01

After rifting from Gondwana in the Late Jurassic - Early Cretaceous, and subsequent opening of the Indian Ocean basin, the continental margins of India developed into typical passive margins. Extensional tectonic forces and thermal subsidence gave rise to the formation of both on-shore and off-shore basins along the southeastern passive margin of the Indian continent, along the Tamil Nadu coast. There, basins such as the Cauvery and Krishna-Godavari basin, accumulated Meso- and Cenozoic (Early Cretaceous to recent) detrital sediments coming off the rifted blocks and the Tamil Nadu hinterland. In places, deep rift basins have accumulated up to over 3000 m of sediments. The continental basement of Tamil Nadu is chiefly composed of metamorphic rocks of the Archean to Palaeoproterozoic Eastern Dharwar Craton and the coeval Southern Granulite Terrane (e.g. Peucat et al., 2013). Several crustal scale shear zones crosscut this assemblage and at least some are considered to represent Gondwanan sutures (Santosh et al., 2012). Smaller, younger granitoid plutons intrude the basement at several locations and most of these are of Late Neoproterozoic age (Glorie et al., 2014). In this work metamorphic basements rocks and the younger granitoids were sampled for a apatite fission-track (AFT) thermochronometric study. A North-South profile from Chennai to Thanjavur mainly transects the Salem block of the Southern Granulite Terrane, and crosscuts several crustal scale shear zones, such as the Cauvery, Salem-Attur and Gangavalli shear zones. Apatites from over 30 samples were used in this study. AFT ages all range between about 190 and 120 Ma (Jurassic - Early Cretaceous). These mainly represent the slow, shallow exhumation of the basement during the rift and early drift phase of the Indian plate from Gondwana. AFT mean track lengths vary between 11 and 13 µm and are typical of slowly exhumed basement. Thermal history modelling (using the QTQt software by Gallagher, 2012) confirms that internal regions of fault blocks experienced a slow and steady cooling to ambient temperatures throughout the Meso-Cenozoic, while younger samples, mainly positioned closeby or inside the shear zones, additionally record a more moderate to rapid cooling since the Early Cenozoic.

Topographic form of the Coast Ranges of the Cascadia Margin in relation ot coastal uplift rates and plate subduction

NASA Technical Reports Server (NTRS)

Kelsey, Harvey M.; Engebretson, David C.; Mitchell, Clifton E.; Ticknor, Robert L.

1994-01-01

The Coast Ranges of the Cascadia margin are overriding the subducted Juan de Fuca/Gorda plate. We investigate the extent to which the latitudinal change in attributes related to the subduction process. These attributes include the varibale age of the subducted slab that underlies the Coast Ranges and average vertical crustal velocities of the western margin of the Coast Rnages for two markedly different time periods, the last 45 years and the last 100 kyr. These vertical crustal velocities are computed from the resurveying of highway bech marks and from the present elevation of shore platforms that have been uplifted in the late Quaternary, respectively. Topogarphy of the Coast Ranges is in part a function of the age and bouyancy of the underlying subducted plate. This is evident in the fact that the two highest topographic elements of the Coast Rnages, the Klamath Mountains and the Olympic Mountains, are underlain by youngest subducted oceanic crust. The subducted Blanco Fracture Zone in southernmost Oregon is responsible for an age discontinuity of subducted crust under the Klamath Mountains. The norhtern terminus of hte topographically higher Klamaths is offset to the north relative to the position of the underlying Blanco Fracture Zone, teh offset being in the direction of migration of the farcture zone, as dictated by relative plate motions. Vertical crustal velocities at the coast, derived from becnh mark surveys, are as much as an order of magnitude greater than vertical crustal velocities derived from uplifted shore platforms. This uplift rate discrepancy indicates that strain is accumulating on the plate margin, to be released during the next interplate earthquake. In a latitudinal sense, average Coast Rnage topography is relatively high where bench mark-derived, short-term vertical crustal velocities are highest. Becuase the shore platform vertical crustal velocities reflect longer-term, premanent uplift, we infer that a small percentage of the interseismic strain that accumulates as rapid short-term uplift is not recovered by subduction earthquakes but rather contributes to rock uplift of the Coast Ranges. The conjecture that permanent rock uplift is related to interseismic uplift is consistent with the observation that those segments of the subduction zone subject to greater interseismic uplift rates are at approximately the same latitudes as those segments of the Coast Ranges that have higher magnitudes of rock uplift over the long term.