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Sample records for blood-based laboratory test

  1. [Decrease in number of venipuncture tubes enables us to shorten turnaround times of blood-based testing in clinical laboratories].

    PubMed

    Uechi, Kohei; Nago, Tamami T; Yamane, Nobuhisa; Yamauchi, Megumi S; Teruya, Emi; Nakasone, Isamu; Higashiuesato, Yasushi

    2013-01-01

    We are making efforts to reduce the number of venipuncture tubes for blood-based testing. On the reconstruction of hematology system in 2011, we planned the system to include hemoglobin A1c (HbA1c) assay and to replace the assay instrument for erythrocyte sedimentation rate (ESR) to use EDTA-2K based whole blood. Accordingly, the revised system required a single test tube for hematological testing, resulting in reduction of blood volume collected. It was estimated that the whole blood collected from outpatients in a year decreased from 143 L to 109 L. Also, the times required to complete venipuncture after outpatient accession were significantly shortened to 10(0.71 +/- 0.27) (2.75-9.55) min, and nearly 50% of outpatients experienced < 2 min of waiting. As the times required for venipuncture were shortened, the turnaround times (TATs) from outpatient accession to finally reporting the test results to physicians were also shortened in the blood-based laboratories. The TATs after outpatient accession to reporting the test results in biochemistry and serology ranged 59 to 80 min (90%-tile), indicating 8 to 16 min less when compared with those before system reconstruction. In conclusion, the decrease in number of venipuncture tubes in hematological testing enables us to reduce the blood volume collected, and to shorten (1) times required for venipuncture procedure, (2) waiting times, and (3) TATs for blood-based testing. However, as demonstrated in HbA1c, i.e., a 50%-tile of TAT for HbA1c delayed for 5 min, the configuration of assay system can greatly influence the TATs of individual test parameters.

  2. Laboratory Tests

    MedlinePlus

    Laboratory tests check a sample of your blood, urine, or body tissues. A technician or your doctor ... compare your results to results from previous tests. Laboratory tests are often part of a routine checkup ...

  3. Prediction of Acute Mountain Sickness using a Blood-Based Test

    DTIC Science & Technology

    2015-01-01

    Award Number: W81XWH-11-2-0034 TITLE: Prediction of Acute Mountain Sickness using a Blood-Based Test PRINCIPAL INVESTIGATOR: Robert Roach...Acute Mountain Sickness using a Blood-Based Test 5a. CONTRACT NUMBER: 5b. GRANT NUMBER W81XWH-11-2-0034 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR... mountain sickness or who was AMS resistant. In Phase II, results suggest a completely independent sample was equally effective in predicting AMS

  4. Prediction of Acute Mountain Sickness using a Blood-Based Test

    DTIC Science & Technology

    2016-01-01

    1 Award Number: W81XWH-11-2-0034 TITLE: Prediction of Acute Mountain Sickness using a Blood-Based Test PRINCIPAL INVESTIGATOR: Robert Roach...Acute Mountain Sickness using a Blood-Based Test 5a. CONTRACT NUMBER: 5b. GRANT NUMBER W81XWH-11-2-0034 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...from a sample taken at sea level could be used to successfully predict in 9 out of 10 individuals who went on to develop acute mountain sickness or

  5. Laboratory tests in rheumatology.

    PubMed

    Caruso, I; Caruso, E M; Signò, P

    1994-09-01

    The most commonly used laboratory tests in the diagnosis and monitoring of rheumatic diseases are reviewed. Particular emphasis is placed on antinuclear antibodies as markers of specific rheumatic disorders and disease subsets. The use of synovial fluid tests to differentiate between inflammatory and noninflammatory rheumatic disorders is described as well as the use of common hematological tests.

  6. SWAT laboratory test results

    NASA Astrophysics Data System (ADS)

    Parenti, Ronald R.; Murphy, Daniel V.

    1993-03-01

    The non-cooperative-target beam-control problem has been the subject of intense investigation since the synthetic-beacon concept was first introduced to the high-energy-laser community in 1982. While numerous analytical studies and computer simulations have been performed to evaluate the practical utility of this phase-measurement technique, prior to Lincoln Laboratory's SWAT (Short-Wavelength Adaptive Techniques) program, no experimental verification had been obtained. In the first phase of the SWAT investigation, completed in 1985, a high degree of correlation between differential-phase measurements from natural and artificial sources was demonstrated. The next phase of the SWAT program will be performed at the AMOS (Air Force Maui Optical Station) facility in Maui, where a 241-actuator adaptive-optics system and an array of six dye lasers will be integrated with the site's 60-cm beam director. Prior to shipment, the adaptive-optics subsystem was subjected to a thorough laboratory evaluation, which culminated in a series of compensation tests involving simulated beacon sources. The results of these measurements are in good agreement with theoretical predictions and provide strong evidence of the efficacy of the synthetic-beacon approach.

  7. Computer integrated laboratory testing

    NASA Technical Reports Server (NTRS)

    Dahl, Charles C.

    1992-01-01

    The objective is the integration of computers into the Engineering Materials Science Laboratory course, where existing test equipment is not computerized. The first lab procedure is to demonstrate and produce a material phase change curve. The second procedure is a demonstration of the modulus of elasticity and related stress-strain curve, plastic performance, maximum and failure strength. The process of recording data by sensors that are connected to a data logger which adds a time base, and the data logger in turn connected to a computer, places the materials labs into a computer integrated mode with minimum expense and maximum flexibility. The sensor signals are input into a spread sheet for tabular records, curve generation, and graph printing.

  8. World of Forensic Laboratory Testing

    MedlinePlus

    ... services. Advertising & Sponsorship: Policy | Opportunities The World of Forensic Laboratory Testing Share this page: Was this page helpful? Overview | Forensic Pathology | Forensic Toxicology | Genetic Tests and DNA Typing | ...

  9. How Reliable Is Laboratory Testing?

    MedlinePlus

    ... methodologies, however, the test results are reported with standardized reference intervals specific for that laboratory. This helps ... an individual's clinical condition to determine if repeat testing would be needed. « Prev | Next » Proudly sponsored by ... ...

  10. [Laboratory accreditation and proficiency testing].

    PubMed

    Kuwa, Katsuhiko

    2003-05-01

    ISO/TC 212 covering clinical laboratory testing and in vitro diagnostic test systems will issue the international standard for medical laboratory quality and competence requirements, ISO 15189. This standard is based on the ISO/IEC 17025, general requirements for competence of testing and calibration laboratories and ISO 9001, quality management systems-requirements. Clinical laboratory services are essential to patient care and therefore should be available to meet the needs of all patients and clinical personnel responsible for human health care. If a laboratory seeks accreditation, it should select an accreditation body that operates according to this international standard and in a manner which takes into account the particular requirements of clinical laboratories. Proficiency testing should be available to evaluate the calibration laboratories and reference measurement laboratories in clinical medicine. Reference measurement procedures should be of precise and the analytical principle of measurement applied should ensure reliability. We should be prepared to establish a quality management system and proficiency testing in clinical laboratories.

  11. Misleading biochemical laboratory test results

    PubMed Central

    Nanji, Amin A.

    1984-01-01

    This article reviews the general and specific factors that interfere with the performance of common biochemical laboratory tests and the interpretation of their results. The clinical status of the patient, drug interactions, and in-vivo and in-vitro biochemical interactions and changes may alter the results obtained from biochemical analysis of blood constituents. Failure to recognize invalid laboratory test results may lead to injudicious and dangerous management of patients. PMID:6375845

  12. Electromedical devices test laboratories accreditation

    NASA Astrophysics Data System (ADS)

    Murad, C.; Rubio, D.; Ponce, S.; Álvarez Abri, A.; Terrón, A.; Vicencio, D.; Fascioli, E.

    2007-11-01

    In the last years, the technology and equipment at hospitals have been increase in a great way as the risks of their implementation. Safety in medical equipment must be considered an important issue to protect patients and their users. For this reason, test and calibrations laboratories must verify the correct performance of this kind of devices under national and international standards. Is an essential mission for laboratories to develop their measurement activities taking into account a quality management system. In this article, we intend to transmit our experience working to achieve an accredited Test Laboratories for medical devices in National technological University.

  13. Development and Clinical Utility of a Blood-Based Test Service for the Rapid Identification of Actionable Mutations in Non-Small Cell Lung Carcinoma.

    PubMed

    Mellert, Hestia; Foreman, Trudi; Jackson, Leisa; Maar, Dianna; Thurston, Scott; Koch, Kristina; Weaver, Amanda; Cooper, Samantha; Dupuis, Nicholas; Sathyanarayana, Ubaradka G; Greer, Jakkie; Hahn, Westen; Shelton, Dawne; Stonemetz, Paula; Pestano, Gary A

    2017-05-01

    Nearly 80% of cancer patients do not have genetic mutation results available at initial oncology consultation; up to 25% of patients begin treatment before receiving their results. These factors hinder the ability to pursue optimal treatment strategies. This study validates a blood-based genome-testing service that provides accurate results within 72 hours. We focused on targetable variants in advanced non-small cell lung carcinoma-epidermal growth factor receptor gene (EGFR) variant L858R, exon 19 deletion (ΔE746-A750), and T790M; GTPase Kirsten ras gene (KRAS) variants G12C/D/V; and echinoderm microtubule associated protein like and 4 anaplastic lymphoma receptor tyrosine kinase fusion (EML4-ALK) transcripts 1/2/3. Test development included method and clinical validation using samples from donors with (n = 219) or without (n = 30) cancer. Clinical sensitivity and specificity for each variant ranged from 78.6% to 100% and 94.2% to 100%, respectively. We also report on 1643 non-small cell lung carcinoma samples processed in our CLIA-certified laboratory. Mutation results were available within 72 hours for 94% of the tests evaluated. We detected 10.5% mutations for EGFR sensitizing (n = 2801 samples tested), 13.8% mutations for EGFR resistance (n = 1055), 13.2% mutations in KRAS (n = 3477), and 2% mutations for EML4-ALK fusion (n = 304). This rapid, highly sensitive, and actionable blood-based assay service expands testing options and supports faster treatment decisions. Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  14. Test Laboratory Facilities and Capabilities

    NASA Technical Reports Server (NTRS)

    Hamilton, Jeff

    2004-01-01

    The Test Laboratory at NASA's Marshall Space Flight Center, located inside the boundaries of 40,000 acre Redstone Arsenal military reservation, has over 50 test facilities across 400+ acres, many inside an additional secure, fenced area. About 150 Government and 250 contractor personnel operate test facilities capable of all types of propulsion and structural testing, from small components to engine systems and structural strength/dynamic and environmental testing. We have tremendous engineering expertise in research, evaluation, analysis, design and development, and test of space transportation systems, subsystems, and components.

  15. Comparison of Nonculture Blood-Based Tests for Diagnosing Invasive Aspergillosis in an Animal Model.

    PubMed

    White, P Lewis; Wiederhold, Nathan P; Loeffler, Juergen; Najvar, Laura K; Melchers, Willem; Herrera, Monica; Bretagne, Stephane; Wickes, Brian; Kirkpatrick, William R; Barnes, Rosemary A; Donnelly, J Peter; Patterson, Thomas F

    2016-04-01

    The EuropeanAspergillusPCR Initiative (EAPCRI) has provided recommendations for the PCR testing of whole blood (WB) and serum/plasma. It is important to test these recommended protocols on nonsimulated "in vivo" specimens before full clinical evaluation. The testing of an animal model of invasive aspergillosis (IA) overcomes the low incidence of disease and provides experimental design and control that is not possible in the clinical setting. Inadequate performance of the recommended protocols at this stage would require reassessment of methods before clinical trials are performed and utility assessed. The manuscript describes the performance of EAPCRI protocols in an animal model of invasive aspergillosis. Blood samples taken from a guinea pig model of IA were used for WB and serum PCR. Galactomannan and β-d-glucan detection were evaluated, with particular focus on the timing of positivity and on the interpretation of combination testing. The overall sensitivities for WB PCR, serum PCR, galactomannan, and β-d-glucan were 73%, 65%, 68%, and 46%, respectively. The corresponding specificities were 92%, 79%, 80%, and 100%, respectively. PCR provided the earliest indicator of IA, and increasing galactomannan and β-d-glucan values were indicators of disease progression. The combination of WB PCR with galactomannan and β-d-glucan proved optimal (area under the curve [AUC], 0.95), and IA was confidently diagnosed or excluded. The EAPRCI-recommended PCR protocols provide performance comparable to commercial antigen tests, and clinical trials are warranted. By combining multiple tests, IA can be excluded or confirmed, highlighting the need for a combined diagnostic strategy. However, this approach must be balanced against the practicality and cost of using multiple tests. Copyright © 2016 White et al.

  16. Field evaluation of a blood based test for active tuberculosis in endemic settings.

    PubMed

    Khaliq, Aasia; Ravindran, Resmi; Hussainy, Syed Fahadulla; Krishnan, Viwanathan V; Ambreen, Atiqa; Yusuf, Noshin Wasim; Irum, Shagufta; Rashid, Abdul; Jamil, Muhammad; Zaffar, Fareed; Chaudhry, Muhammad Nawaz; Gupta, Puneet K; Akhtar, Muhammad Waheed; Khan, Imran H

    2017-01-01

    Over 9 million new active tuberculosis (TB) cases emerge each year from an enormous pool of 2 billion individuals latently infected with Mycobacterium tuberculosis (M. tb.) worldwide. About 3 million new TB cases per year are unaccounted for, and 1.5 million die. TB, however, is generally curable if diagnosed correctly and in a timely manner. The current diagnostic methods for TB, including state-of-the-art molecular tests, have failed in delivering the capacity needed in endemic countries to curtail this ongoing pandemic. Efficient, cost effective and scalable diagnostic approaches are critically needed. We report a multiplex TB serology panel using microbead suspension array containing a combination of 11 M.tb. antigens that demonstrated overall sensitivity of 91% in serum/plasma samples from TB patients confirmed by culture. Group wise sensitivities for sputum smear positive and negative patients were 95%, and 88%, respectively. Specificity of the test was 96% in untreated COPD patients and 91% in general healthy population. The sensitivity of this test is superior to that of the frontline sputum smear test with a comparable specificity (30-70%, and 93-99%, respectively). The multiplex serology test can be performed with scalability from 1 to 360 patients per day, and is amenable to automation for higher (1000s per day) throughput, thus enabling a scalable clinical work flow model for TB endemic countries. Taken together, the above results suggest that well defined antibody profiles in blood, analyzed by an appropriate technology platform, offer a valuable approach to TB diagnostics in endemic countries.

  17. Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset.

    PubMed

    Chan, M K; Krebs, M-O; Cox, D; Guest, P C; Yolken, R H; Rahmoune, H; Rothermundt, M; Steiner, J; Leweke, F M; van Beveren, N J M; Niebuhr, D W; Weber, N S; Cowan, D N; Suarez-Pinilla, P; Crespo-Facorro, B; Mam-Lam-Fook, C; Bourgin, J; Wenstrup, R J; Kaldate, R R; Cooper, J D; Bahn, S

    2015-07-14

    Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development of a serum biomarker test for the identification of individuals at risk of developing schizophrenia based on multiplex immunoassay profiling analysis of 957 serum samples. First, we conducted a meta-analysis of five independent cohorts of 127 first-onset drug-naive schizophrenia patients and 204 controls. Using least absolute shrinkage and selection operator regression, we identified an optimal panel of 26 biomarkers that best discriminated patients and controls. Next, we successfully validated this biomarker panel using two independent validation cohorts of 93 patients and 88 controls, which yielded an area under the curve (AUC) of 0.97 (0.95-1.00) for schizophrenia detection. Finally, we tested its predictive performance for identifying patients before onset of psychosis using two cohorts of 445 pre-onset or at-risk individuals. The predictive performance achieved by the panel was excellent for identifying USA military personnel (AUC: 0.90 (0.86-0.95)) and help-seeking prodromal individuals (AUC: 0.82 (0.71-0.93)) who developed schizophrenia up to 2 years after baseline sampling. The performance increased further using the latter cohort following the incorporation of CAARMS (Comprehensive Assessment of At-Risk Mental State) positive subscale symptom scores into the model (AUC: 0.90 (0.82-0.98)). The current findings may represent the first successful step towards a test that could address the clinical need for early intervention in psychiatry. Further developments of a combined molecular/symptom-based test will aid clinicians in the identification of vulnerable patients early in the disease process, allowing more effective therapeutic intervention before overt disease onset.

  18. 3. VIEW LOOKING NORTH, COMPONENTS TEST LABORATORY, DYNAMIC TEST FACILITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW LOOKING NORTH, COMPONENTS TEST LABORATORY, DYNAMIC TEST FACILITY (SATURN V IN BACKGROUND). - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

  19. Laboratory testing for prescription opioids.

    PubMed

    Milone, Michael C

    2012-12-01

    Opioid analgesic misuse has risen significantly over the past two decades, and these drugs now represent the most commonly abused class of prescription medications. They are a major cause of poisoning deaths in the USA exceeding heroin and cocaine. Laboratory testing plays a role in the detection of opioid misuse and the evaluation of patients with opioid intoxication. Laboratories use both immunoassay and chromatographic methods (e.g., liquid chromatography with mass spectrometry detection), often in combination, to yield high detection sensitivity and drug specificity. Testing methods for opioids originated in the workplace-testing arena and focused on detection of illicit heroin use. Analysis for a wide range of opioids is now required in the context of the prescription opioid epidemic. Testing methods have also been primarily based upon urine screening; however, methods for analyzing alternative samples such as saliva, sweat, and hair are available. Application of testing to monitor prescription opioid drug therapy is an increasingly important use of drug testing, and this area of testing introduces new interpretative challenges. In particular, drug metabolism may transform one clinically available opioid into another. The sensitivity of testing methods also varies considerably across the spectrum of opioid drugs. An understanding of opioid metabolism and method sensitivity towards different opioid drugs is therefore essential to effective use of these tests. Improved testing algorithms and more research into the effective use of drug testing in the clinical setting, particularly in pain medicine and substance abuse, are needed.

  20. Laboratory test system. Final report

    SciTech Connect

    Asher, G.L.

    1980-03-01

    This project was initiated to develop a laboratory test capability for evaluating new and existing digital product designs. In recent years, Bendix Kansas City has become more active in syppling early development hardware to the design laboratories for evaluation. Because of the more complex electronic designs being used in new components, more highly automated test systems are needed to evaluate development hardware. To meet this requirement, a universal test system was developed to provide both basic test capabilities and flexibility to adapt easily to specific product applications. This laboratory evaluation system will reduce the need to develop complex dedicated test systems for each new product design, while still providing the benefits of an automated system. A special purpose interface chassis was designed and fabricated to permit a standardized interface between the test system and the product application. Connector assignments by system functions provide convenience and function isolation. Standard cables were used to reduce the need for special purpose hardware. Electrical testing of a developmental electronics assembly demonstrated the adaptability of this system for a typical product application. Both the interface hardware and the software were developed for this application.

  1. Laboratory tests for oxidative stress.

    PubMed

    Agarwal, Ashok; Majzoub, Ahmad

    2017-01-01

    Oxidative stress (OS) is considered a significant contributor to male infertility. A number of laboratory techniques have been developed to evaluate oxidative stress in the semen. We review these tests and their current use. A literature review was performed utilizing the PubMed search engine for articles studying OS etiology and impact on male fertility, and the laboratory tests used in its assessment. The state of OS results from exaggerated production of oxygen-derived free radicals, also known as reactive oxygen species, to an extent overwhelming the body's antioxidant defense mechanisms. Several laboratory tests have been utilized in OS measurement during male fertility evaluation. These tests are classified into direct assays which measure the degree of oxidation within a sperm cell and indirect assays which estimate the detrimental effects of OS. The chemiluminescence assay, flow cytometry, nitroblue tetrazolium assay, and cytochrome c reduction are examples of direct assays while the myeloperoxidase test and measurements of lipid peroxidation, oxidation-reduction potential, and total antioxidant capacity are examples of the indirect assays. OS measurement is an important tool that may help in understanding the pathophysiology of male infertility and provide valuable information that would guide treatment decisions and patient follow-up.

  2. Epi proColon(®) 2.0 CE: A Blood-Based Screening Test for Colorectal Cancer.

    PubMed

    Lamb, Yvette N; Dhillon, Sohita

    2017-04-01

    Epi proColon(®) 2.0 CE is a blood-based test designed to aid in the early detection of colorectal cancer. The test comprises a qualitative assay for the polymerase chain reaction (PCR) detection of methylated Septin9 DNA, the presence of which is associated with colorectal cancer: however, positive results should be verified by colonoscopy or sigmoidoscopy. Epi proColon(®) 2.0 CE discriminated between patients with colorectal cancer and healthy controls with high clinical sensitivity and specificity in pivotal case-control studies. The sensitivity of the test did not appear to be affected by the tumour location or by patient age or gender. In addition, limited data suggest that Epi proColon(®) 2.0 CE discriminated between patients with colorectal cancer and healthy controls with higher sensitivity and generally similar specificity to that of the faecal immunochemical test, and with higher sensitivity and specificity to that of the guaiac-based faecal occult blood test (statistical data not available). In an observational study, most patients who refused colonoscopy for screening accepted a non-invasive test option as an alternative, and preferred Epi proColon(®) 2.0 CE over a stool-based test. Large prospective trials of Epi proColon(®) 2.0 CE in a screening setting will be required to further elucidate the cost-effectiveness of the test. Nevertheless, currently available data suggests that Epi proColon(®) 2.0 CE has the potential to be a sensitive and convenient screening option for patients refusing screening by colonoscopy.

  3. Educational ultrasound nondestructive testing laboratory.

    PubMed

    Genis, Vladimir; Zagorski, Michael

    2008-09-01

    The ultrasound nondestructive evaluation (NDE) of materials course was developed for applied engineering technology students at Drexel University's Goodwin College of Professional Studies. This three-credit, hands-on laboratory course consists of two parts: the first part with an emphasis on the foundations of NDE, and the second part during which ultrasound NDE techniques are utilized in the evaluation of parts and materials. NDE applications are presented and applied through real-life problems, including calibration and use of the latest ultrasonic testing instrumentation. The students learn engineering and physical principles of measurements of sound velocity in different materials, attenuation coefficients, material thickness, and location and dimensions of discontinuities in various materials, such as holes, cracks, and flaws. The work in the laboratory enhances the fundamentals taught during classroom sessions. This course will ultimately result in improvements in the educational process ["The greater expectations," national panel report, http://www.greaterexpectations.org (last viewed February, 2008); R. M. Felder and R. Brent "The intellectual development of Science and Engineering Students. Part 2: Teaching to promote growth," J. Eng. Educ. 93, 279-291 (2004)] since industry is becoming increasingly reliant on the effective application of NDE technology and the demand on NDE specialists is increasing. NDE curriculum was designed to fulfill levels I and II NDE in theory and training requirements, according to American Society for Nondestructive Testing, OH, Recommended Practice No. SNT-TC-1A (2006).

  4. Laboratory tests of antifungal drugs.

    PubMed Central

    Holt, R J

    1975-01-01

    The procedures evolved in the author's laboratory over the past 20 years for the microbiological assessment of antifungal drugs are described; methods are detailed for the estimation of the sensitivity of pathogenic fungi to therapeutic agents and for the assay of those agents in body fluids. The preparation and maintenance of stock reference solutions of the drugs, the culture media used, and the incubation temperature and time are discussed. Sensitivity tests by paper disc and by liquid titration for minimal inhibitory and cidal concentrations estimated are described, and the importance of standardized initial inocula is emphasized. Two groups of assay procedures are given, the liquid dilution and the agar diffusion methods, and suitable indicator organisms for both methods are named. The paper concludes with a discussion on the problem of differential assays when two antimycotic agents are in simultaneous clinical use. Images PMID:765359

  5. CERTS Microgrid Laboratory Test Bed

    SciTech Connect

    Lasseter, R. H.; Eto, J. H.; Schenkman, B.; Stevens, J.; Volkmmer, H.; Klapp, D.; Linton, E.; Hurtado, H.; Roy, J.

    2010-06-08

    CERTS Microgrid concept captures the emerging potential of distributed generation using a system approach. CERTS views generation and associated loads as a subsystem or a 'microgrid'. The sources can operate in parallel to the grid or can operate in island, providing UPS services. The system can disconnect from the utility during large events (i.e. faults, voltage collapses), but may also intentionally disconnect when the quality of power from the grid falls below certain standards. CERTS Microgrid concepts were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations, and finally through factory acceptance testing of individual microgrid components. The islanding and resynchronization method met all Institute of Electrical and Electronics Engineers Standard 1547 and power quality requirements. The electrical protection system was able to distinguish between normal and faulted operation. The controls were found to be robust under all conditions, including difficult motor starts and high impedance faults.

  6. CERTS Microgrid Laboratory Test Bed

    SciTech Connect

    Eto, Joe; Lasseter, Robert; Schenkman, Ben; Stevens, John; Klapp, Dave; Volkommer, Harry; Linton, Ed; Hurtado, Hector; Roy, Jean

    2009-06-18

    The objective of the CERTS Microgrid Test Bed project was to enhance the ease of integrating energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of generating sources less than 100kW. The techniques comprising the CERTS Microgrid concept are: 1) a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation, islanding the microgrid's load from a disturbance, thereby maintaining a higher level of service, without impacting the integrity of the utility's electrical power grid; 2) an approach to electrical protection within a limited source microgrid that does not depend on high fault currents; and 3) a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications between sources. These techniques were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations,and finally through factory acceptance testing of individual microgrid components. The islanding and resychronization method met all Institute of Electrical and Electronics Engineers Standard 1547 and power quality requirements. The electrical protection system was able to distinguish between normal and faulted operation. The controls were found to be robust under all conditions, including difficult motor starts and high impedance faults. The results from these tests are expected to lead to additional testing of enhancements to the basic techniques at the test bed to improve the business case for microgrid technologies, as well to field demonstrations

  7. Harmonization of Clinical Laboratory Test Results.

    PubMed

    2016-02-01

    Clinical laboratory testing is now a global activity with laboratories no longer working in isolation but as regional and national networks, and often at international levels. We now have all of the electronic gadgetry via internet technology at our fingertips to rapidly and accurately measure and report on laboratory testing but are our test results harmonized?

  8. Testing containment of laboratory hoods

    SciTech Connect

    Knutson, G.W.

    1987-06-01

    Laboratory fume hoods often do not adequately provide protection to a chemist or technician at the hood. The reason for failure of the hoods to perform adequately are varied and, in many instances, difficult to determine. In some cases, the laboratory hood manufacturer has provided equipment that does not reflect the state of art in controlling laboratory exposures. In other cases, the architect or engineer has disregarded the function of the hood thus the design of the installation is faulty and the hood will not work. The contractor may have installed the system so poorly that it will not adequately function. Finally, the chemist or technician may misuse the hood, causing poor performance. This paper considers a method of evaluating the performance of laboratory fume hoods. Using the method, the paper examines several instances where the laboratory fume hood performed inadequately, quantifies the performance and identifies the cause of poor performance.

  9. Some new tests at the Gottingen laboratory

    NASA Technical Reports Server (NTRS)

    1921-01-01

    The tests at the Gottingen laboratory included: friction tests on a surface treated with omelette, verification tests on the M.V.A. 356 wing, and comparative tests of wing no. 36 at the Eiffel laboratory. The examination of all these experiments leads to the belief that, at large incidences, the speeds registered by the suction manometer of the testing chamber of the Eiffel laboratory wind tunnel are, owing to pressure drop, greater than the actual speeds. Therefore, the values of k(sub x) and k(sub y) measured at the Eiffel laboratory at large incidences are too low.

  10. Postirradiation Testing Laboratory (327 Building)

    SciTech Connect

    Kammenzind, D.E.

    1997-05-28

    A Standards/Requirements Identification Document (S/RID) is the total list of the Environment, Safety and Health (ES and H) requirements to be implemented by a site, facility, or activity. These requirements are appropriate to the life cycle phase to achieve an adequate level of protection for worker and public health and safety, and the environment during design, construction, operation, decontamination and decommissioning, and environmental restoration. S/RlDs are living documents, to be revised appropriately based on change in the site`s or facility`s mission or configuration, a change in the facility`s life cycle phase, or a change to the applicable standards/requirements. S/RIDs encompass health and safety, environmental, and safety related safeguards and security (S and S) standards/requirements related to the functional areas listed in the US Department of Energy (DOE) Environment, Safety and Health Configuration Guide. The Fluor Daniel Hanford (FDH) Contract S/RID contains standards/requirements, applicable to FDH and FDH subcontractors, necessary for safe operation of Project Hanford Management Contract (PHMC) facilities, that are not the direct responsibility of the facility manager (e.g., a site-wide fire department). Facility S/RIDs contain standards/requirements applicable to a specific facility that are the direct responsibility of the facility manager. S/RlDs are prepared by those responsible for managing the operation of facilities or the conduct of activities that present a potential threat to the health and safety of workers, public, or the environment, including: Hazard Category 1 and 2 nuclear facilities and activities, as defined in DOE 5480.23. Selected Hazard Category 3 nuclear, and Low Hazard non-nuclear facilities and activities, as agreed upon by RL. The Postirradiation Testing Laboratory (PTL) S/RID contains standards/ requirements that are necessary for safe operation of the PTL facility, and other building/areas that are the direct

  11. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1403 Condition: Laboratories performing moderate complexity testing; laboratory director. The...

  12. Laboratory tests, interpretation, and use of resources

    PubMed Central

    Abbott, Marcia; Paulin, Heidi; Sidhu, Davinder; Naugler, Christopher

    2014-01-01

    Abstract Problem addressed The overuse of laboratory testing has increased rapidly and is contributing to the financial strain on the health care system in Canada. Moreover, a substantial proportion of ordered tests are unnecessary. In a search of all the Canadian family physician residency programs, none lists laboratory training as mandatory or as an optional elective in its curriculum. Objective of program To introduce family medicine residents to appropriate and efficient use of laboratory tests. Program description The program was run as a series of identical 4-hour small group sessions to facilitate discussion and laboratory tours. The curriculum focused on 7 key topics: problems associated with laboratory testing, sources of laboratory errors, definitions of normal and abnormal test results, appropriate use of laboratory requisition forms, laboratory quality assurance methods, laboratory collection processes, and costs of common laboratory tests. Residents were taken to a patient specimen collection site for a tour and introduction, followed by approximately 2 hours of didactic sessions, and ending with a tour of a large tertiary care testing facility. Conclusion The program was very well received by family medicine residents and resulted in a substantial increase in residents’ self-assessed knowledge of the 7 topics covered in the curriculum. It is hoped that this program will fill an important gap in residency training and support residents’ competency in the “selectivity” domain of training. PMID:24627400

  13. Putting New Laboratory Tests Into Practice

    MedlinePlus

    ... products and services. Advertising & Sponsorship: Policy | Opportunities Putting New Laboratory Tests into Practice Share this page: Was this page helpful? Introduction | Why develop new tests | Regulation | Gaining acceptance | Conclusion | Sources Overview This ...

  14. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as required...

  15. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as...

  16. Cruise Stage Testing for Mars Science Laboratory

    NASA Image and Video Library

    2010-09-02

    Testing of the cruise stage for NASA Mars Science Laboratory in August 2010 included a session in a facility that simulates the environment found in interplanetary space. Spacecraft technicians at JPL prepare a space-simulation test.

  17. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as required...

  18. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as required...

  19. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as required...

  20. Laboratory Performance Testing of Residential Dehumidifiers (Presentation)

    SciTech Connect

    Winkler, J.

    2012-03-01

    Six residential vapor compression cycle dehumidifiers spanning the available range of capacities and efficiencies were tested in the National Renewable Energy Laboratory's Heating, Ventilating, and Air-Conditioning Systems Laboratory. Each was tested under a wide range of indoor air conditions to facilitate the development of performance curves for use in whole-building simulation tools.

  1. Laboratory Soils Testing. Change 2

    DTIC Science & Technology

    1986-08-20

    7. PLASTICITY INDEX ...................... 111-20 8. REPORT .............................. 111-2 0 9. PREPARING CLAY SHALE MATERIAL FOR TESTING...V-8 4. COMBINED ANALYSIS & . ,,,,,,, v-21 5. PROCEDURES FOR PREPARING CLAY i . , SHALE MATERIAL . * , , , a , a , , , , V-24 6. POSSIBLE ERRORS...XII- 7 6. COMPUTATIONS ................. XII.-1 7. POSSIBLE ERRORS . .1 1 XII-12 * APPENDIX XIIA: MODIFIED PROVIDENCE VIBRATED DENSITY TEST

  2. NASA White Sands Test Facility Remote Hypervelocity Test Laboratory

    NASA Image and Video Library

    Tour the NASA White Sands Test Facility's Remote Hypervelocity Test Laboratory in Las Cruces, New Mexico. To learn more about White Sands Test Facility, go to http://www.nasa.gov/centers/wstf/home/...

  3. "Certified" Laboratory Practitioners and the Accuracy of Laboratory Test Results.

    ERIC Educational Resources Information Center

    Boe, Gerard P.; Fidler, James R.

    1988-01-01

    An attempt to replicate a study of the accuracy of test results of medical laboratories was unsuccessful. Limitations of the obtained data prevented the research from having satisfactory internal validity, so no formal report was published. External validity of the study was also limited because the systematic random sample of 78 licensed…

  4. Crime Laboratory Proficiency Testing Research Program.

    ERIC Educational Resources Information Center

    Peterson, Joseph L.; And Others

    A three-year research effort was conducted to design a crime laboratory proficiency testing program encompassing the United States. The objectives were to: (1) determine the feasibility of preparation and distribution of different classes of physical evidence; (2) assess the accuracy of criminalistics laboratories in the processing of selected…

  5. Crime Laboratory Proficiency Testing Research Program.

    ERIC Educational Resources Information Center

    Peterson, Joseph L.; And Others

    A three-year research effort was conducted to design a crime laboratory proficiency testing program encompassing the United States. The objectives were to: (1) determine the feasibility of preparation and distribution of different classes of physical evidence; (2) assess the accuracy of criminalistics laboratories in the processing of selected…

  6. CERTS Microgrid Laboratory Test Bed

    SciTech Connect

    ETO, J.; LASSETER, R.; SCHENKMAN, B.; STEVENS, J.; KLAPP, D.; VOLKOMMER, H.; LINTON, E.; HURTADO, H.; ROY, J.

    2010-06-08

    The objective of the CERTS Microgrid Test Bed project was to enhance the ease of integrating energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of generating sources less than 100kW. The techniques comprising the CERTS Microgrid concept are: 1 a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation, islanding the microgrid's load from a disturbance, thereby maintaining a higher level of service, without impacting the integrity of the utility's electrical power grid; 2 an approach to electrical protection within a limited source microgrid that does not depend on high fault currents; and 3 a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications between sources.

  7. Laboratory tests and compliance of dermatologic outpatients

    PubMed Central

    Kim, Jaehwan

    2013-01-01

    Laboratory tests, including blood tests and urine analysis, are frequently performed in the dermatology outpatient clinic, but doctors often do not consider the cognitive or psychological effect of the examinations. Based on terror management theory, we hypothesized that performing laboratory tests increases the patient’s fear of mortality, and therefore has a positive effect on the patient’s attitude toward the doctor’s recommendations and willingness to accept them. The study employed a single factor between-subjects design, using a questionnaire completed by the patients. One group consisted of patients who had undergone laboratory tests 1 week before the survey, and the other group consisted of patients who had not undergone a laboratory test. Although the differences between two groups were not statistically significant, the patients who had laboratory tests had tendency to show even lower positive attitude toward the doctor’s recommendations and less intention to follow the recommendations. In contrast to our hypothesis, performing laboratory tests does not subliminally increase patients’ fears or anxieties about their disease or their compliance with doctors’ recommendations. PMID:24555101

  8. The Mars Science Laboratory Touchdown Test Facility

    NASA Technical Reports Server (NTRS)

    White, Christopher; Frankovich, John; Yates, Phillip; Wells Jr, George H.; Losey, Robert

    2009-01-01

    In the Touchdown Test Program for the Mars Science Laboratory (MSL) mission, a facility was developed to use a full-scale rover vehicle and an overhead winch system to replicate the Skycrane landing event.

  9. Parachute Testing for Mars Science Laboratory

    NASA Image and Video Library

    2007-12-20

    The team developing the landing system for NASA Mars Science Laboratory tested the deployment of an early parachute design in mid-October 2007 inside the world largest wind tunnel, at NASA Ames Research Center, Moffett Field, California.

  10. Mars Science Laboratory Spacecraft Assembled for Testing

    NASA Image and Video Library

    2008-11-19

    The major components of NASA Mars Science Laboratory spacecraft -- cruise stage atop the aeroshell, which has the descent stage and rover inside -- were connected together in October 2008 for several weeks of system testing.

  11. Antinuclear antibody testing: discordance between commercial laboratories.

    PubMed

    Abeles, Aryeh M; Gomez-Ramirez, Manuel; Abeles, Micha; Honiden, Shyoko

    2016-07-01

    Antinuclear antibody (ANA) test results frequently affect the course of patients' evaluations, diagnosis, and treatment, but different laboratory centers may yield conflicting results. This study investigated the degree of agreement between laboratory results in a group of subjects who had ANA testing performed at two commercial laboratories. This was a chart review study, in which all ANA tests ordered by the authors from one commercial laboratory over a 4-year period were queried. Corresponding patient charts were reviewed, and if ANA testing had also been performed at the second commercial laboratory, subjects were entered into the study. The primary measurement was agreement between paired ANA results, and we performed sensitivity analysis using varying criteria defining agreement (criteria A to criteria D [strictest to most lenient definition of agreement]). Other data captured included relevant data obtained through the course of evaluation (e.g., presenting complaints, exam findings, other laboratory data) and final diagnoses. Of 101 paired ANA tests, there was 18 % agreement according to the strictest criteria and 42 % according to the most lenient. Of the seven subjects with ANA-associated rheumatic disease, none of the paired tests were in agreement according to criteria A (two agreed according to criteria D). Our findings demonstrate poor agreement between paired ANA tests performed at two commercial laboratories. The low level of agreement may have far-reaching clinical implications. Specifically, this finding calls into question the reliability of ANA testing as it is currently performed and suggests that results may in part depend upon the laboratory center to which patients are referred.

  12. Mars Science Laboratory Spacecraft Assembled for Testing

    NASA Technical Reports Server (NTRS)

    2008-01-01

    The major components of NASA's Mars Science Laboratory spacecraft cruise stage atop the aeroshell, which has the descent stage and rover inside were connected together in October 2008 for several weeks of system testing, including simulation of launch vibrations and deep-space environmental conditions.

    These components will be taken apart again, for further work on each of them, after the environmental testing. The Mars Science Laboratory spacecraft is being assembled and tested for launch in 2011.

    This image was taken inside the Spacecraft Assembly Facility at NASA's Jet Propulsion Laboratory, Pasadena, Calif., which manages the Mars Science Laboratory Project for the NASA Science Mission Directorate, Washington. JPL is a division of the California Institute of Technology.

  13. Mars Science Laboratory Spacecraft Assembled for Testing

    NASA Technical Reports Server (NTRS)

    2008-01-01

    The major components of NASA's Mars Science Laboratory spacecraft cruise stage atop the aeroshell, which has the descent stage and rover inside were connected together in October 2008 for several weeks of system testing, including simulation of launch vibrations and deep-space environmental conditions.

    These components will be taken apart again, for further work on each of them, after the environmental testing. The Mars Science Laboratory spacecraft is being assembled and tested for launch in 2011.

    This image was taken inside the Spacecraft Assembly Facility at NASA's Jet Propulsion Laboratory, Pasadena, Calif., which manages the Mars Science Laboratory Project for the NASA Science Mission Directorate, Washington. JPL is a division of the California Institute of Technology.

  14. Systems integration test laboratory application & experiences

    NASA Astrophysics Data System (ADS)

    Rimer, Melvyn; Falco, Michael; Solan, Michael J.

    1991-01-01

    The ability to safely control highly dynamic systems is of prime importance to designers. Whether the system is an aircraft, spacecraft, or propulsion system, control system designers must turn to test laboratories not only to verify and validate the control systems, but also to actually use the laboratory as a design and development tool. The use of the laboratory early in the development phase of a system—prior to committing to actual hardware/software (HW/SW)—permits early detection of system anomalies, thereby minimizing program development costs while enhancing safety. Later the laboratory can be used to train system operators (for example, pilots, ground crew) in preparation for flight/ground test. In the case of the statically unstable X-29 forward swept wing aircraft, a comprehensive real-time, hardware-in-the-loop test facility was critical in the development of the aircraft's digital fly-by-wire (FBW) flight control system. The X-29 laboratory initially was used to introduce control laws to a simulated real-time environment to verify control system characteristics. Later, actual flight hardware was introduced to the laboratory, at which point the formal system verification/validation test program began. The test program utilized detailed test plans and procedures derived from system requirements and specifications to map out all tests required. This assured that the maximum number of components of the system were exercised in the laboratory, and all components tested had traceability throughout the test program. The end-to-end hardware-in-the loop simulation provided the environment to perform critical failure modes testing, parameter sensitivity evaluation and ultimately pilot/ground crew training during normal and degraded flight control system operation. The X-29 test experience, applicable to the laboratory testing of all critical control systems, has ingrained the philosophy that successful development of complex systems requires an orderly build

  15. Radiographic testing at Lawrence Livermore National Laboratory

    SciTech Connect

    Bossi, R.H.

    1982-04-21

    Radiographic testing is a nondestructive inspection technique which uses penetrating radiation. The Nondestructive Evaluation (NDE) Section at Lawrence Livermore National Laboratory has a broad spectrum of equipment and techniques for radiographic testing. These resources include low-energy vacuum systems, low- and mid-energy cabinet and cell radiographic systems, high-energy linear accelerators, portable x-ray machines and radioisotopes for radiographic inspections. For diagnostic testing the NDE Section also has real-time and flash radiographic equipment.

  16. Evaluation of Mycology Laboratory Proficiency Testing

    PubMed Central

    Reilly, Andrew A.; Salkin, Ira F.; McGinnis, Michael R.; Gromadzki, Sally; Pasarell, Lester; Kemna, Maggi; Higgins, Nancy; Salfinger, Max

    1999-01-01

    Changes over the last decade in overt proficiency testing (OPT) regulations have been ostensibly directed at improving laboratory performance on patient samples. However, the overt (unblinded) format of the tests and regulatory penalties associated with incorrect values allow and encourage laboratorians to take extra precautions with OPT analytes. As a result OPT may measure optimal laboratory performance instead of the intended target of typical performance attained during routine patient testing. This study addresses this issue by evaluating medical mycology OPT and comparing its fungal specimen identification error rates to those obtained in a covert (blinded) proficiency testing (CPT) program. Identifications from 188 laboratories participating in the New York State mycology OPT from 1982 to 1994 were compared with the identifications of the same fungi recovered from patient specimens in 1989 and 1994 as part of the routine procedures of 88 of these laboratories. The consistency in the identification of OPT specimens was sufficient to make accurate predictions of OPT error rates. However, while the error rates in OPT and CPT were similar for Candida albicans, significantly higher error rates were found in CPT for Candida tropicalis, Candida glabrata, and other common pathogenic fungi. These differences may, in part, be due to OPT’s use of ideal organism representatives cultured under optimum growth conditions. This difference, as well as the organism-dependent error rate differences, reflects the limitations of OPT as a means of assessing the quality of routine laboratory performance in medical mycology. PMID:10364601

  17. The emergence of point-of-care blood-based biomarker testing for psychiatric disorders: enabling personalized medicine.

    PubMed

    Guest, Francesca L; Guest, Paul C; Martins-de-Souza, Daniel

    2016-01-01

    For psychiatric disorders, repeated failures in converting scientific discoveries into novel drugs has precipitated a crisis and eroded confidence in drug discovery. This review describes how current and future innovations driven by application of biomarkers can help to re-initiate research in this area. This will have positive impact on the field of psychiatry and result in application of sensitive and specific biochemical tests in parallel with the traditional questionnaires for improved diagnosis. Furthermore, application of emerging biosensor tools will facilitate point-of-care testing by fusion of biochemical and clinical data. In this way, patient data will be comprised of past medical histories, biopatterns and prognosis information, resulting in personalized profiles or molecular fingerprints for patients with these conditions.

  18. 222-S LABORATORY FUME HOOD TESTING STUDY

    SciTech Connect

    RUELAS, B.H.

    2007-03-26

    The 222-S Laboratory contains 155 active fume hoods that are used to support analytical work with radioactive and/or toxic materials. The performance of a fume hood was brought into question after employees detected odors in the work area while mixing chemicals within the subject fume hood. Following the event, testing of the fume hood was conducted to assess the performance of the fume hood. Based on observations from the testing, it was deemed appropriate to conduct performance evaluations of other fume hoods within the laboratory.

  19. Managing demand for laboratory tests: a laboratory toolkit.

    PubMed

    Fryer, Anthony A; Smellie, W Stuart A

    2013-01-01

    Healthcare budgets worldwide are facing increasing pressure to reduce costs and improve efficiency, while maintaining quality. Laboratory testing has not escaped this pressure, particularly since pathology investigations cost the National Health Service £2.5 billion per year. Indeed, the Carter Review, a UK Department of Health-commissioned review of pathology services in England, estimated that 20% of this could be saved by improving pathology services, despite an average annual increase of 8%-10% in workload. One area of increasing importance is managing the demands for pathology tests and reducing inappropriate requesting. The Carter Review estimated that 25% of pathology tests were unnecessary, representing a huge potential waste. Certainly, the large variability in levels of requesting between general practitioners suggests that inappropriate requesting is widespread. Unlocking the key to this variation and implementing measures to reduce inappropriate requesting would have major implications for patients and healthcare resources alike. This article reviews the approaches to demand management. Specifically, it aims to (a) define demand management and inappropriate requesting, (b) assess the drivers for demand management, (c) examine the various approaches used, illustrating the potential of electronic requesting and (d) provide a wider context. It will cover issues, such as educational approaches, information technology opportunities and challenges, vetting, duplicate request identification and management, the role of key performance indicators, profile composition and assessment of downstream impact of inappropriate requesting. Currently, many laboratories are exploring demand management using a plethora of disparate approaches. Hence, this review seeks to provide a 'toolkit' with the view to allowing laboratories to develop a standardised demand management strategy.

  20. [Laboratory tests for parasitic diseases in Israel].

    PubMed

    Marva, Esther; Grossman, Tamar

    2010-09-01

    Microscopic examination is still considered the gold standard for the diagnosis of parasitic diseases. In many clinical laboratories in hospitals and in health maintenance organizations ("Kupot Holim"), an excellent microscopic identification of parasites is performed. Microscopic examinations using wet mount preparations are performed for the detection of protozoan trophozoites and helmintic ova or larvae. Specific concentration techniques, including flotation and sedimentation procedures are further performed for the diagnosis of parasitic diseases. However, microscopic examinations are time-consuming, non-sensitive and not always reliable. Furthermore, the diagnosis of certain infections is not always possible by searching for the parasites in host tissues or excreta since risky invasive techniques might be necessary to locate the parasites. Detection of antibodies can be very useful as an indication for infection with a specific parasite, especially in individuals with no exposure to the parasite prior to recent travel in a disease-endemic area. In addition to serology, there are other tests of high sensitivity which can be integrated with microscopy, such as antigen detection in stool and blood samples as well as the use of other molecular diagnosis methods. There are two main laboratories in Israel where parasitic diagnosis is available by integration of microscopy, serology, antigen detection and molecular methods: The Reference Laboratory for Parasitology in Jerusalem at the Central Laboratories of the Ministry of Health (MOH) and the Laboratory of Parasitology at Soroka University Medical Center, Beer Sheva (SOR). There are also two special diagnostic units, one responsible for the identification of toxopLasma: Reference Laboratory for Toxoplasmosis, Public Health Laboratory, Ministry of Health, Tel Aviv (Tox), and the other for the identification of Leishmaniasis: Kuvin Center, Faculty of Medicine, Hebrew University of Jerusalem (Kuv). This article

  1. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  2. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  3. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  4. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  5. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  6. Mars Science Laboratory Workstation Test Set

    NASA Technical Reports Server (NTRS)

    Henriquez, David A.; Canham, Timothy K.; Chang, Johnny T.; Villaume, Nathaniel

    2009-01-01

    The Mars Science Laboratory developed the Workstation TestSet (WSTS) is a computer program that enables flight software development on virtual MSL avionics. The WSTS is the non-real-time flight avionics simulator that is designed to be completely software-based and run on a workstation class Linux PC.

  7. Battery testing at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1993-03-25

    Argonne National Laboratory`s Analysis & Diagnostic Laboratory (ADL) tests advanced batteries under simulated electric and hybrid vehicle operating conditions. The ADL facilities also include a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The battery evaluations and post-test examinations help identify factors that limit system performance and life, and the most-promising R&D approaches for overcoming these limitations. Since 1991, performance characterizations and/or life evaluations have been conducted on eight battery technologies (Na/S, Li/S, Zn/Br, Ni/MH, Ni/Zn, Ni/Cd, Ni/Fe, and lead-acid). These evaluations were performed for the Department of Energy`s. Office of Transportation Technologies, Electric and Hybrid Propulsion Division (DOE/OTT/EHP), and Electric Power Research Institute (EPRI) Transportation Program. The results obtained are discussed.

  8. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1441 Condition: Laboratories performing high complexity testing; laboratory director. The laboratory must have...

  9. Engineering and Design: Laboratory Investigations and Testing

    DTIC Science & Technology

    2007-11-02

    Requirements for Hazardous, Toxic, and Radioactive Waste (HTRW) and Ordnance and Explosive Waste (OEW) Activities . b. ER 1110-1-261, Quality Assurance of...Laboratory Testing Procedures. c. ER 1110-1-263, Chemical Data Quality Management for Hazardous Waste Remedial Activities . d. ER 1110-1-2002, Cement...Slag, and Pozzolan Acceptance Testing. e. ER 1110-2-8154, Water Quality Management at Corps Civil Works Projects. f. ER 200-2-3, Environmental

  10. Laboratory tests for single-event effects

    SciTech Connect

    Buchner, S.; McMorrow, D.; Melinger, J.; Campbell, A.B.

    1996-04-01

    Integrated circuits are currently tested at accelerators for their susceptibility to single-event effects (SEE`s). However, because of the cost and limited accessibility associated with accelerator testing, there is considerable interest in developing alternate testing methods. Two laboratory techniques for measuring SEE, one involving a pulsed laser and the other {sup 252}Cf, are described in detail in this paper. The pulsed laser provides information on the spatial and temporal dependence of SEE, information that has proven invaluable in understanding and mitigating SEE in spite of the differences in the physical mechanisms responsible for SEE induced by light and by ions. Considerable effort has been expended on developing {sup 252}Cf as a laboratory test for SEE, but the technique has not found wide use because it is severely limited by the low energy and short range of the emitted ions that are unable to reach junctions either covered with dielectric layers or deep below the surface. In fact, there are documented cases where single-event latchup (SEL) testing with {sub 252}Cf gave significantly different results from accelerator testing. A detailed comparison of laboratory and accelerator SEE data is presented in this review in order to establish the limits of each technique.

  11. CTBTO Contractor Laboratory Test Sample Production Report

    SciTech Connect

    Bob Hague; Tracy Houghton; Nick Mann; Matt Watrous

    2013-08-01

    In October 2012 scientists from both Idaho National Laboratory (INL) and the CTBTO contact laboratory at Seibersdorf, Austria designed a system and capability test to determine if the INL could produce and deliver a short lived radio xenon standard in time for the standard to be measured at the CTBTO contact laboratory at Seibersdorf, Austria. The test included sample standard transportation duration and potential country entrance delays at customs. On October 23, 2012 scientists at the Idaho National Laboratory (INL) prepared and shipped a Seibersdorf contract laboratory supplied cylinder. The canister contained 1.0 scc of gas that consisted of 70% xenon and 30% nitrogen by volume. The t0 was October 24, 2012, 1200 ZULU. The xenon content was 0.70 +/ 0.01 scc at 0 degrees C. The 133mXe content was 4200 +/ 155 dpm per scc of stable xenon on t0 (1 sigma uncertainty). The 133Xe content was 19000 +/ 800 dpm per scc of stable xenon on t0 (1 sigma uncertainty).

  12. Advanced Materials Laboratory User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Orndoff, Evelyne

    2012-01-01

    Test process, milestones and inputs are unknowns to first-time users of the Advanced Materials Laboratory. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  13. Parachute Testing for Mars Science Laboratory

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The team developing the landing system for NASA's Mars Science Laboratory tested the deployment of an early parachute design in mid-October 2007 inside the world's largest wind tunnel, at NASA Ames Research Center, Moffett Field, California.

    In this image, an engineer is dwarfed by the parachute, which holds more air than a 280-square-meter (3,000-square-foot) house and is designed to survive loads in excess of 36,000 kilograms (80,000 pounds).

    The parachute, built by Pioneer Aerospace, South Windsor, Connecticut, has 80 suspension lines, measures more than 50 meters (165 feet) in length, and opens to a diameter of nearly 17 meters (55 feet). It is the largest disk-gap-band parachute ever built and is shown here inflated in the test section with only about 3.8 meters (12.5 feet) of clearance to both the floor and ceiling.

    The wind tunnel, which is 24 meters (80 feet) tall and 37 meters (120 feet) wide and big enough to house a Boeing 737, is part of the National Full-Scale Aerodynamics Complex, operated by the U.S. Air Force, Arnold Engineering Development Center.

    NASA's Jet Propulsion Laboratory, Pasadena, California, is building and testing the Mars Science Laboratory spacecraft for launch in 2009. The mission will land a roving analytical laboratory on the surface of Mars in 2010. JPL is a division of the California Institute of Technology.

  14. Parachute Testing for Mars Science Laboratory

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The team developing the landing system for NASA's Mars Science Laboratory tested the deployment of an early parachute design in mid-October 2007 inside the world's largest wind tunnel, at NASA Ames Research Center, Moffett Field, California.

    In this image, an engineer is dwarfed by the parachute, which holds more air than a 280-square-meter (3,000-square-foot) house and is designed to survive loads in excess of 36,000 kilograms (80,000 pounds).

    The parachute, built by Pioneer Aerospace, South Windsor, Connecticut, has 80 suspension lines, measures more than 50 meters (165 feet) in length, and opens to a diameter of nearly 17 meters (55 feet). It is the largest disk-gap-band parachute ever built and is shown here inflated in the test section with only about 3.8 meters (12.5 feet) of clearance to both the floor and ceiling.

    The wind tunnel, which is 24 meters (80 feet) tall and 37 meters (120 feet) wide and big enough to house a Boeing 737, is part of the National Full-Scale Aerodynamics Complex, operated by the U.S. Air Force, Arnold Engineering Development Center.

    NASA's Jet Propulsion Laboratory, Pasadena, California, is building and testing the Mars Science Laboratory spacecraft for launch in 2009. The mission will land a roving analytical laboratory on the surface of Mars in 2010. JPL is a division of the California Institute of Technology.

  15. Battery testing at Argonne National Laboratory

    NASA Astrophysics Data System (ADS)

    Deluca, W. H.; Gillie, K. R.; Kulaga, J. E.; Smaga, J. A.; Tummillo, A. F.; Webster, C. E.

    Advanced battery technology evaluations are performed under simulated electric-vehicle operating conditions at the Analysis & Diagnostic Laboratory (ADL) of Argonne National Laboratory. The ADL results provide insight into those factors that limit battery performance and life. The ADL facilities include a test laboratory to conduct battery experimental evaluations under simulated application conditions and a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. This paper summarizes the performance characterizations and life evaluations conducted during FY-92 on both single cells and multi-cell modules that encompass six battery technologies (Na/S, Li/FeS, Ni/Metal-Hydride, Ni/Zn, Ni/Cd, Ni/Fe). These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division, and the Electric Power Research Institute. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The results help identify the most promising R&D approaches for overcoming battery limitations, and provide battery users, developers, and program managers with a measure of the progress being made in battery R&D programs, a comparison of battery technologies, and basic data for modeling.

  16. Battery testing at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1992-01-01

    Advanced battery technology evaluations are performed under simulated electric-vehicle operating conditions at the Analysis Diagnostic Laboratory (ADL) of Argonne National Laboratory. The ADL results provide insight into those factors that limit battery performance and life. The ADL facilities include a test laboratory to conduct battery experimental evaluations under simulated application conditions and a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. This paper summarizes the performance characterizations and life evaluations conducted during FY 1992 on both single cells and multi-cell modules that encompass six battery technologies [Na/S, Li/FeS, Ni/Metal-Hydride, Ni/Zn, Ni/Cd, Ni/Fe]. These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division, and the Electric Power Research Institute. The ADL provides a common basis for battery performance characterization and lie evaluations with unbiased application of tests and analyses. The results help identify the most promising R D approaches for overcoming battery limitations, and provide battery users, developers, and program managers with a measure of the progress being made in battery R D programs, a comparison of battery technologies, and basic data for modeling.

  17. Iowa Central Quality Fuel Testing Laboratory

    SciTech Connect

    Heach, Don; Bidieman, Julaine

    2013-09-30

    The objective of this project is to finalize the creation of an independent quality fuel testing laboratory on the campus of Iowa Central Community College in Fort Dodge, Iowa that shall provide the exploding biofuels industry a timely and cost-effective centrally located laboratory to complete all state and federal fuel and related tests that are required. The recipient shall work with various state regulatory agencies, biofuel companies and state and national industry associations to ensure that training and testing needs of their members and American consumers are met. The recipient shall work with the Iowa Department of Ag and Land Stewardship on the development of an Iowa Biofuel Quality Standard along with the Development of a standard that can be used throughout industry.

  18. Developing a cardiopulmonary exercise testing laboratory.

    PubMed

    Diamond, Edward

    2007-12-01

    Cardiopulmonary exercise testing is a noninvasive and cost-effective technique that adds significant value to the assessment and management of a variety of symptoms and diseases. The penetration of this testing in medical practice may be limited by perceived operational and financial barriers. This article reviews coding and supervision requirements related to both simple and complex pulmonary stress testing. A program evaluation and review technique diagram is used to describe the work flow process. Data from our laboratory are used to generate an income statement that separates fixed and variable costs and calculates the contribution margin. A cost-volume-profit (break-even) analysis is then performed. Using data from our laboratory including fixed and variable costs, payer mix, reimbursements by payer, and the assumption that the studies are divided evenly between simple and complex pulmonary stress tests, the break-even number is calculated to be 300 tests per year. A calculator with embedded formulas has been designed by the author and is available on request. Developing a cardiopulmonary exercise laboratory is challenging but achievable and potentially profitable. It should be considered by a practice that seeks to distinguish itself as a quality leader. Providing this clinically valuable service may yield indirect benefits such as increased patient volume and increased utilization of other services provided by the practice. The decision for a medical practice to commit resources to managerial accounting support requires a cost-benefit analysis, but may be a worthwhile investment in our challenging economic environment.

  19. 1. VIEW EAST, COMPONENTS TEST LABORATORY SHOWING CATCH BASINS, TURBINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW EAST, COMPONENTS TEST LABORATORY SHOWING CATCH BASINS, TURBINE TESTING AREA, AND PUMP TESTING TOWER. - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

  20. Could light meal jeopardize laboratory coagulation tests?

    PubMed Central

    Lima-Oliveira, Gabriel; Salvagno, Gian Luca; Lippi, Giuseppe; Danese, Elisa; Gelati, Matteo; Montagnana, Martina; Picheth, Geraldo; Guidi, Gian Cesare

    2014-01-01

    Background: Presently the necessity of fasting time for coagulation tests is not standardized. Our hypothesis is that this can harm patient safety. This study is aimed at evaluating whether a light meal (i.e. breakfast) can jeopardize laboratory coagulation tests. Materials and methods: A blood sample was firstly collected from 17 fasting volunteers (12 h). Immediately after blood collection, the volunteers consumed a light meal. Then samples were collected at 1, 2 and 4 h after the meal. Coagulation tests included: activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fbg), antithrombin III (AT), protein C (PC) and protein S (PS). Differences between samples were assessed by Wilcoxon ranked-pairs test. The level of statistical significance was set at P < 0.05. Mean % differences were determined and differences between and baseline and 1, 2 and 4h samples were compared with reference change value (RCV). Results: A significantly higher % activity of AT was observed at 1 h and 4 h after meal vs. baseline specimen [113 (104–117) and 111 (107–120) vs. 109 (102–118), respectively; P = 0.029 and P = 0.016]. APTT at 2 h was found significantly lower than baseline samples [32.0 (29.9–34.8) vs. 34.1 (32.2–35.2), respectively; P = 0.041]. The results of both Fbg and PS tests were not influenced by a light meal. Furthermore, no coagulation tests had significant variation after comparison with RCV. Conclusion: A light meal does not influence the laboratory coagulation tests we assessed, but we suggest that the laboratory quality managers standardize the fasting time for all blood tests at 12 hours, to completely metabolize the lipids intake. PMID:25351352

  1. Could light meal jeopardize laboratory coagulation tests?

    PubMed

    Lima-Oliveira, Gabriel; Salvagno, Gian Luca; Lippi, Giuseppe; Danese, Elisa; Gelati, Matteo; Montagnana, Martina; Picheth, Geraldo; Guidi, Gian Cesare

    2014-01-01

    Presently the necessity of fasting time for coagulation tests is not standardized. Our hypothesis is that this can harm patient safety. This study is aimed at evaluating whether a light meal (i.e. breakfast) can jeopardize laboratory coagulation tests. A blood sample was firstly collected from 17 fasting volunteers (12 h). Immediately after blood collection, the volunteers consumed a light meal. Then samples were collected at 1, 2 and 4 h after the meal. Coagulation tests included: activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fbg), antithrombin III (AT), protein C (PC) and protein S (PS). Differences between samples were assessed by Wilcoxon ranked-pairs test. The level of statistical significance was set at P < 0.05. Mean % differences were determined and differences between and baseline and 1, 2 and 4h samples were compared with reference change value (RCV). A significantly higher % activity of AT was observed at 1 h and 4 h after meal vs. baseline specimen [113 (104-117) and 111 (107-120) vs. 109 (102-118), respectively; P = 0.029 and P = 0.016]. APTT at 2 h was found significantly lower than baseline samples [32.0 (29.9-34.8) vs. 34.1 (32.2-35.2), respectively; P = 0.041]. The results of both Fbg and PS tests were not influenced by a light meal. Furthermore, no coagulation tests had significant variation after comparison with RCV. A light meal does not influence the laboratory coagulation tests we assessed, but we suggest that the laboratory quality managers standardize the fasting time for all blood tests at 12 hours, to completely metabolize the lipids intake.

  2. Battery testing at Argonne National Laboratory

    NASA Astrophysics Data System (ADS)

    Deluca, W. H.; Gillie, K. R.; Kulaga, J. E.; Smaga, J. A.; Tummillo, A. F.; Webster, C. E.

    1993-03-01

    Argonne National Laboratory's Analysis & Diagnostic Laboratory (ADL) tests advanced batteries under simulated electric and hybrid vehicle operating conditions. The ADL facilities also include a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The battery evaluations and post-test examinations help identify factors that limit system performance and life and the most-promising R&D approaches for overcoming these limitations. Since 1991, performance characterizations and/or life evaluations have been conducted on eight battery technologies: Na/S, Li/S, Zn/Br, Ni/MH, Ni/Zn, Ni/Cd, Ni/Fe, and lead-acid. These evaluations were performed for the Department of Energy's. Office of Transportation Technologies, Electric and Hybrid Propulsion Division (DOE/OTT/EHP), and Electric Power Research Institute (EPRI) Transportation Program. The results obtained are discussed.

  3. Battery testing at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1993-03-25

    Argonne National Laboratory's Analysis Diagnostic Laboratory (ADL) tests advanced batteries under simulated electric and hybrid vehicle operating conditions. The ADL facilities also include a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The battery evaluations and post-test examinations help identify factors that limit system performance and life, and the most-promising R D approaches for overcoming these limitations. Since 1991, performance characterizations and/or life evaluations have been conducted on eight battery technologies (Na/S, Li/S, Zn/Br, Ni/MH, Ni/Zn, Ni/Cd, Ni/Fe, and lead-acid). These evaluations were performed for the Department of Energy's. Office of Transportation Technologies, Electric and Hybrid Propulsion Division (DOE/OTT/EHP), and Electric Power Research Institute (EPRI) Transportation Program. The results obtained are discussed.

  4. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1441 Condition: Laboratories performing high complexity testing; laboratory director. The laboratory must have a...

  5. 42 CFR 493.1421 - Condition: Laboratories performing moderate complexity testing; testing personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... complexity testing; testing personnel. 493.1421 Section 493.1421 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1421 Condition: Laboratories performing moderate complexity testing; testing personnel....

  6. 42 CFR 493.1421 - Condition: Laboratories performing moderate complexity testing; testing personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... complexity testing; testing personnel. 493.1421 Section 493.1421 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1421 Condition: Laboratories performing moderate complexity testing; testing personnel....

  7. 42 CFR 493.1421 - Condition: Laboratories performing moderate complexity testing; testing personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... complexity testing; testing personnel. 493.1421 Section 493.1421 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1421 Condition: Laboratories performing moderate complexity testing; testing personnel. The...

  8. Mars Science Laboratory Rover System Thermal Test

    NASA Technical Reports Server (NTRS)

    Novak, Keith S.; Kempenaar, Joshua E.; Liu, Yuanming; Bhandari, Pradeep; Dudik, Brenda A.

    2012-01-01

    On November 26, 2011, NASA launched a large (900 kg) rover as part of the Mars Science Laboratory (MSL) mission to Mars. The MSL rover is scheduled to land on Mars on August 5, 2012. Prior to launch, the Rover was successfully operated in simulated mission extreme environments during a 16-day long Rover System Thermal Test (STT). This paper describes the MSL Rover STT, test planning, test execution, test results, thermal model correlation and flight predictions. The rover was tested in the JPL 25-Foot Diameter Space Simulator Facility at the Jet Propulsion Laboratory (JPL). The Rover operated in simulated Cruise (vacuum) and Mars Surface environments (8 Torr nitrogen gas) with mission extreme hot and cold boundary conditions. A Xenon lamp solar simulator was used to impose simulated solar loads on the rover during a bounding hot case and during a simulated Mars diurnal test case. All thermal hardware was exercised and performed nominally. The Rover Heat Rejection System, a liquid-phase fluid loop used to transport heat in and out of the electronics boxes inside the rover chassis, performed better than predicted. Steady state and transient data were collected to allow correlation of analytical thermal models. These thermal models were subsequently used to predict rover thermal performance for the MSL Gale Crater landing site. Models predict that critical hardware temperatures will be maintained within allowable flight limits over the entire 669 Sol surface mission.

  9. Mars Science Laboratory Rover System Thermal Test

    NASA Technical Reports Server (NTRS)

    Novak, Keith S.; Kempenaar, Joshua E.; Liu, Yuanming; Bhandari, Pradeep; Dudik, Brenda A.

    2012-01-01

    On November 26, 2011, NASA launched a large (900 kg) rover as part of the Mars Science Laboratory (MSL) mission to Mars. The MSL rover is scheduled to land on Mars on August 5, 2012. Prior to launch, the Rover was successfully operated in simulated mission extreme environments during a 16-day long Rover System Thermal Test (STT). This paper describes the MSL Rover STT, test planning, test execution, test results, thermal model correlation and flight predictions. The rover was tested in the JPL 25-Foot Diameter Space Simulator Facility at the Jet Propulsion Laboratory (JPL). The Rover operated in simulated Cruise (vacuum) and Mars Surface environments (8 Torr nitrogen gas) with mission extreme hot and cold boundary conditions. A Xenon lamp solar simulator was used to impose simulated solar loads on the rover during a bounding hot case and during a simulated Mars diurnal test case. All thermal hardware was exercised and performed nominally. The Rover Heat Rejection System, a liquid-phase fluid loop used to transport heat in and out of the electronics boxes inside the rover chassis, performed better than predicted. Steady state and transient data were collected to allow correlation of analytical thermal models. These thermal models were subsequently used to predict rover thermal performance for the MSL Gale Crater landing site. Models predict that critical hardware temperatures will be maintained within allowable flight limits over the entire 669 Sol surface mission.

  10. Laboratory Tests in the Rheumatic Disease

    PubMed Central

    Aaron, S.L.

    1988-01-01

    Because the pathophysiologic relationship between laboratory and clinical abnormalities in many of the rheumatologic diseases is still not clearly understood, the use of the investigations dealt with in this article is based only upon statistics. The interpretation of these tests is therefore highly dependent on the result of the initial clinical assessment. Having accepted this limitation, however, the rheumatologist has available a number of powerful tools which may be used to diagnose, classify, or prognosticate. ImagesFigure 1 PMID:21253052

  11. The Brookhaven National Laboratory Accelerator Test Facility

    SciTech Connect

    Batchelor, K.

    1992-01-01

    The Brookhaven National Laboratory Accelerator Test Facility comprises a 50 MeV traveling wave electron linear accelerator utilizing a high gradient, photo-excited, raidofrequency electron gun as an injector and an experimental area for study of new acceleration methods or advanced radiation sources using free electron lasers. Early operation of the linear accelerator system including calculated and measured beam parameters are presented together with the experimental program for accelerator physics and free electron laser studies.

  12. The Brookhaven National Laboratory Accelerator Test Facility

    SciTech Connect

    Batchelor, K.

    1992-09-01

    The Brookhaven National Laboratory Accelerator Test Facility comprises a 50 MeV traveling wave electron linear accelerator utilizing a high gradient, photo-excited, raidofrequency electron gun as an injector and an experimental area for study of new acceleration methods or advanced radiation sources using free electron lasers. Early operation of the linear accelerator system including calculated and measured beam parameters are presented together with the experimental program for accelerator physics and free electron laser studies.

  13. Automation software for a materials testing laboratory

    NASA Technical Reports Server (NTRS)

    Mcgaw, Michael A.; Bonacuse, Peter J.

    1986-01-01

    A comprehensive software system for automating much of the experimental process has recently been completed at the Lewis Research Center's high-temperature fatigue and structures laboratory. The system was designed to support experiment definition and conduct, results analysis and archiving, and report generation activities. This was accomplished through the design and construction of several software systems, as well as through the use of several commercially available software products, all operating on a local, distributed minicomputer system. Experimental capabilities currently supported in an automated fashion include both isothermal and thermomechanical fatigue and deformation testing capabilities. The future growth and expansion of this system will be directed toward providing multiaxial test control, enhanced thermomechanical test control, and higher test frequency (hundreds of hertz).

  14. The laboratory test utilization management toolbox

    PubMed Central

    Baird, Geoffrey

    2014-01-01

    Efficiently managing laboratory test utilization requires both ensuring adequate utilization of needed tests in some patients and discouraging superfluous tests in other patients. After the difficult clinical decision is made to define the patients that do and do not need a test, a wealth of interventions are available to the clinician and laboratorian to help guide appropriate utilization. These interventions are collectively referred to here as the utilization management toolbox. Experience has shown that some tools in the toolbox are weak and other are strong, and that tools are most effective when many are used simultaneously. While the outcomes of utilization management studies are not always as concrete as may be desired, what data is available in the literature indicate that strong utilization management interventions are safe and effective measures to improve patient health and reduce waste in an era of increasing financial pressure. PMID:24969916

  15. Laboratory tests of sludge-control additives

    SciTech Connect

    Tatnall, R.E.

    1996-07-01

    Laboratory {open_quotes}jar{close_quotes} tests compared eleven different fuel oil and diesel fuel sludge-control additives. Factors studied included (1) ability to disperse and prevent buildup of sludge deposits on surfaces, (2) ability to protect steel from corrosion, (3) ability to inhibit growth and proliferation of bacteria, and (4) ability to disperse water. Results varied greatly, and it was found that many commercial products do not do what they claim. It is concluded that fuel retailers should not believe manufacturers` claims for their additive products, but rather should test such products themselves to be sure that the benefits of treatment are real. A simplified form of the procedure used here is proposed as one way for dealers to do such testing.

  16. Laboratory procedures for waste form testing

    SciTech Connect

    Mast, E.S.

    1994-09-19

    The 100 and 300 areas of the Hanford Site are included on the US Environmental Protection Agencies (EPA) National Priorities List under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). Soil washing is a treatment process that is being considered for the remediation of the soil in these areas. Contaminated soil washing fines can be mixed or blended with cementations materials to produce stable waste forms that can be used for beneficial purposes in mixed or low-level waste landfills, burial trenches, environmental restoration sites, and other applications. This process has been termed co-disposal. The Co-Disposal Treatability Study Test Plan is designed to identify a range of cement-based formulations that could be used in disposal efforts in Hanford in co-disposal applications. The purpose of this document is to provide explicit procedural information for the testing of co-disposal formulations. This plan also provides a discussion of laboratory safety and quality assurance necessary to ensure safe, reproducible testing in the laboratory.

  17. Laboratory rock mechanics testing manual. Public draft

    SciTech Connect

    Shuri, F S; Cooper, J D; Hamill, M L

    1981-10-01

    Standardized laboratory rock mechanics testing procedures have been prepared for use in the National Terminal Waste Storage Program. The procedures emphasize equipment performance specifications, documentation and reporting, and Quality Assurance acceptance criteria. Sufficient theoretical background is included to allow the user to perform the necessary data reduction. These procedures incorporate existing standards when possible, otherwise they represent the current state-of-the-art. Maximum flexibility in equipment design has been incorporated to allow use of this manual by existing groups and to encourage future improvements.

  18. Test plan for ISV laboratory-pyrolysis testing

    SciTech Connect

    McAtee, R.E.

    1991-09-01

    The objective of the laboratory-pyrolysis studies is to obtain information on the high temperature (< 1200{degree}C) degradation and alteration of organic chemicals and materials similar to those found in the Radioactive Waste Management Complex, Pit 9. This test plan describes experimental procedures, sampling and analysis strategy, sampling procedures, sample control, and document management. It addresses safety issues in the experimental apparatus and procedures, personal training, and hazardous waste disposal. Finally, it describes the data quality objectives using the EPA tiered approach to treatability studies to define where research/scoping tests fit into these studies and the EPA analytical levels required for the tests.

  19. Test plan for ISV laboratory-pyrolysis testing

    SciTech Connect

    McAtee, R.E.

    1991-09-01

    The objective of the laboratory-pyrolysis studies is to obtain information on the high temperature (< 1200{degree}C) degradation and alteration of organic chemicals and materials similar to those found in the Radioactive Waste Management Complex, Pit 9. This test plan describes experimental procedures, sampling and analysis strategy, sampling procedures, sample control, and document management. It addresses safety issues in the experimental apparatus and procedures, personal training, and hazardous waste disposal. Finally, it describes the data quality objectives using the EPA tiered approach to treatability studies to define where research/scoping tests fit into these studies and the EPA analytical levels required for the tests.

  20. Remotely accessible laboratory for MEMS testing

    NASA Astrophysics Data System (ADS)

    Sivakumar, Ganapathy; Mulsow, Matthew; Melinger, Aaron; Lacouture, Shelby; Dallas, Tim E.

    2010-02-01

    We report on the construction of a remotely accessible and interactive laboratory for testing microdevices (aka: MicroElectroMechancial Systems - MEMS). Enabling expanded utilization of microdevices for research, commercial, and educational purposes is very important for driving the creation of future MEMS devices and applications. Unfortunately, the relatively high costs associated with MEMS devices and testing infrastructure makes widespread access to the world of MEMS difficult. The creation of a virtual lab to control and actuate MEMS devices over the internet helps spread knowledge to a larger audience. A host laboratory has been established that contains a digital microscope, microdevices, controllers, and computers that can be logged into through the internet. The overall layout of the tele-operated MEMS laboratory system can be divided into two major parts: the server side and the client side. The server-side is present at Texas Tech University, and hosts a server machine that runs the Linux operating system and is used for interfacing the MEMS lab with the outside world via internet. The controls from the clients are transferred to the lab side through the server interface. The server interacts with the electronics required to drive the MEMS devices using a range of National Instruments hardware and LabView Virtual Instruments. An optical microscope (100 ×) with a CCD video camera is used to capture images of the operating MEMS. The server broadcasts the live video stream over the internet to the clients through the website. When the button is pressed on the website, the MEMS device responds and the video stream shows the movement in close to real time.

  1. Getting ELMER ready for science: laboratory tests

    NASA Astrophysics Data System (ADS)

    García-Vargas, M. L.; Rodríguez-Espinosa, J. M.; Martín-Fleitas, J. M.; Kohley, R.; Sánchez-Blanco, E.; Hammersley, P. L.; Cabrera-Lavers, A.; Maldonado, M.; Vilela, R.

    2006-06-01

    Elmer is an imager and spectrograph in the visible range that has been designed and managed within the GTC Project Office. Elmer will be installed at the telescope at the beginning of the commissioning phase. The observing modes of the instrument are: Imaging, Long Slit, Mask and Slit-less multi-object Spectroscopy, Fast Photometry and Fast short-slit Spectroscopy. The pupil elements are a set of conventional broad band and narrow band filters as well as a set of prisms, grisms and VPHs, that allow spectroscopy with resolving powers of 200, 1000 and 2500 between 365 and 1000nm. Elmer has been exhaustively tested and each of its observing modes has been fully characterized at the laboratory. This contribution summarizes the results of this Test Plan, showing the excellent performance of Elmer in both, Imaging and Spectroscopy modes that, together with the GTC, will lead to a powerful scientific return.

  2. Thermal-Structures and Materials Testing Laboratory

    NASA Technical Reports Server (NTRS)

    Teate, Anthony A.

    1997-01-01

    Since its inception and successful implementation in 1997 at James Madison University, the Thermal Structures and Materials Testing Laboratory (T-SaMTL) funded by the NASA Langley Research Center is evolving into one of the University's premier and exemplary efforts to increase minority representation in the sciences and mathematics. Serving ten (10) students and faculty directly and almost fifty (50) students indirectly, T-SAMTL, through its recruitment efforts, workshops, mentoring program, tutorial services and its research and computational laboratories has marked the completion of the first year with support from NASA totaling $ 100,000. Beginning as an innovative academic research and mentoring program for underrepresented minority science and mathematics students, the program now boasts a constituency which consists of 50% graduating seniors in the spring of 1998 with 50% planning to go to graduate school. The program's intent is to increase the number of underrepresented minorities who receive doctoral degrees in the sciences by initiating an academically enriched research program aimed at strengthening the academic and self actualization skills of undergraduate students with the potential to pursue doctoral study in the sciences. The program provides financial assistance, academic enrichment, and professional and personal development support for minority students who demonstrate the potential and strong desire to pursue careers in the sciences and mathematics. James Madison University was awarded the first $100,000, in April 1997, by The NASA Langley Research Center for establishment and support of its Thermal Structures and Materials Testing

  3. Thermal-Structures and Materials Testing Laboratory

    NASA Technical Reports Server (NTRS)

    Teate, Anthony A.

    1997-01-01

    Since its inception and successful implementation in 1997 at James Madison University, the Thermal Structures and Materials Testing Laboratory (T-SaMTL) funded by the NASA Langley Research Center is evolving into one of the University's premier and exemplary efforts to increase minority representation in the sciences and mathematics. Serving ten (10) students and faculty directly and almost fifty (50) students indirectly, T-SAMTL, through its recruitment efforts, workshops, mentoring program, tutorial services and its research and computational laboratories has marked the completion of the first year with support from NASA totaling $ 100,000. Beginning as an innovative academic research and mentoring program for underrepresented minority science and mathematics students, the program now boasts a constituency which consists of 50% graduating seniors in the spring of 1998 with 50% planning to go to graduate school. The program's intent is to increase the number of underrepresented minorities who receive doctoral degrees in the sciences by initiating an academically enriched research program aimed at strengthening the academic and self actualization skills of undergraduate students with the potential to pursue doctoral study in the sciences. The program provides financial assistance, academic enrichment, and professional and personal development support for minority students who demonstrate the potential and strong desire to pursue careers in the sciences and mathematics. James Madison University was awarded the first $100,000, in April 1997, by The NASA Langley Research Center for establishment and support of its Thermal Structures and Materials Testing

  4. Mars Science Laboratory Flight Software Internal Testing

    NASA Technical Reports Server (NTRS)

    Jones, Justin D.; Lam, Danny

    2011-01-01

    The Mars Science Laboratory (MSL) team is sending the rover, Curiosity, to Mars, and therefore is physically and technically complex. During my stay, I have assisted the MSL Flight Software (FSW) team in implementing functional test scripts to ensure that the FSW performs to the best of its abilities. There are a large number of FSW requirements that have been written up for implementation; however I have only been assigned a few sections of these requirements. There are many stages within testing; one of the early stages is FSW Internal Testing (FIT). The FIT team can accomplish this with simulation software and the MSL Test Automation Kit (MTAK). MTAK has the ability to integrate with the Software Simulation Equipment (SSE) and the Mission Processing and Control System (MPCS) software which makes it a powerful tool within the MSL FSW development process. The MSL team must ensure that the rover accomplishes all stages of the mission successfully. Due to the natural complexity of this project there is a strong emphasis on testing, as failure is not an option. The entire mission could be jeopardized if something is overlooked.

  5. Mars Science Laboratory Flight Software Internal Testing

    NASA Technical Reports Server (NTRS)

    Jones, Justin D.; Lam, Danny

    2011-01-01

    The Mars Science Laboratory (MSL) team is sending the rover, Curiosity, to Mars, and therefore is physically and technically complex. During my stay, I have assisted the MSL Flight Software (FSW) team in implementing functional test scripts to ensure that the FSW performs to the best of its abilities. There are a large number of FSW requirements that have been written up for implementation; however I have only been assigned a few sections of these requirements. There are many stages within testing; one of the early stages is FSW Internal Testing (FIT). The FIT team can accomplish this with simulation software and the MSL Test Automation Kit (MTAK). MTAK has the ability to integrate with the Software Simulation Equipment (SSE) and the Mission Processing and Control System (MPCS) software which makes it a powerful tool within the MSL FSW development process. The MSL team must ensure that the rover accomplishes all stages of the mission successfully. Due to the natural complexity of this project there is a strong emphasis on testing, as failure is not an option. The entire mission could be jeopardized if something is overlooked.

  6. Electronics systems test laboratory testing of shuttle communications systems

    NASA Technical Reports Server (NTRS)

    Stoker, C. J.; Bromley, L. K.

    1985-01-01

    Shuttle communications and tracking systems space to space and space to ground compatibility and performance evaluations are conducted in the NASA Johnson Space Center Electronics Systems Test Laboratory (ESTL). This evaluation is accomplished through systems verification/certification tests using orbiter communications hardware in conjunction with other shuttle communications and tracking external elements to evaluate end to end system compatibility and to verify/certify that overall system performance meets program requirements before manned flight usage. In this role, the ESTL serves as a multielement major ground test facility. The ESTL capability and program concept are discussed. The system test philosophy for the complex communications channels is described in terms of the major phases. Results of space to space and space to ground systems tests are presented. Several examples of the ESTL's unique capabilities to locate and help resolve potential problems are discussed in detail.

  7. Laboratory test surveillance following acute kidney injury.

    PubMed

    Matheny, Michael E; Peterson, Josh F; Eden, Svetlana K; Hung, Adriana M; Speroff, Theodore; Abdel-Kader, Khaled; Parr, Sharidan K; Ikizler, T Alp; Siew, Edward D

    2014-01-01

    Patients with hospitalized acute kidney injury (AKI) are at increased risk for accelerated loss of kidney function, morbidity, and mortality. We sought to inform efforts at improving post-AKI outcomes by describing the receipt of renal-specific laboratory test surveillance among a large high-risk cohort. We acquired clinical data from the Electronic health record (EHR) of 5 Veterans Affairs (VA) hospitals to identify patients hospitalized with AKI from January 1st, 2002 to December 31st, 2009, and followed these patients for 1 year or until death, enrollment in palliative care, or improvement in renal function to estimated GFR (eGFR) ≥ 60 L/min/1.73 m(2). Using demographic data, administrative codes, and laboratory test data, we evaluated the receipt and timing of outpatient testing for serum concentrations of creatinine and any as well as quantitative proteinuria recommended for CKD risk stratification. Additionally, we reported the rate of phosphorus and parathyroid hormone (PTH) monitoring recommended for chronic kidney disease (CKD) patients. A total of 10,955 patients admitted with AKI were discharged with an eGFR<60 mL/min/1.73 m2. During outpatient follow-up at 90 and 365 days, respectively, creatinine was measured on 69% and 85% of patients, quantitative proteinuria was measured on 6% and 12% of patients, PTH or phosphorus was measured on 10% and 15% of patients. Measurement of creatinine was common among all patients following AKI. However, patients with AKI were infrequently monitored with assessments of quantitative proteinuria or mineral metabolism disorder, even for patients with baseline kidney disease.

  8. Laboratory Test Surveillance following Acute Kidney Injury

    PubMed Central

    Matheny, Michael E.; Peterson, Josh F.; Eden, Svetlana K.; Hung, Adriana M.; Speroff, Theodore; Abdel-Kader, Khaled; Parr, Sharidan K.; Ikizler, T. Alp; Siew, Edward D.

    2014-01-01

    Background Patients with hospitalized acute kidney injury (AKI) are at increased risk for accelerated loss of kidney function, morbidity, and mortality. We sought to inform efforts at improving post-AKI outcomes by describing the receipt of renal-specific laboratory test surveillance among a large high-risk cohort. Methods We acquired clinical data from the Electronic health record (EHR) of 5 Veterans Affairs (VA) hospitals to identify patients hospitalized with AKI from January 1st, 2002 to December 31st, 2009, and followed these patients for 1 year or until death, enrollment in palliative care, or improvement in renal function to estimated GFR (eGFR) ≥60 L/min/1.73 m2. Using demographic data, administrative codes, and laboratory test data, we evaluated the receipt and timing of outpatient testing for serum concentrations of creatinine and any as well as quantitative proteinuria recommended for CKD risk stratification. Additionally, we reported the rate of phosphorus and parathyroid hormone (PTH) monitoring recommended for chronic kidney disease (CKD) patients. Results A total of 10,955 patients admitted with AKI were discharged with an eGFR<60 mL/min/1.73 m2. During outpatient follow-up at 90 and 365 days, respectively, creatinine was measured on 69% and 85% of patients, quantitative proteinuria was measured on 6% and 12% of patients, PTH or phosphorus was measured on 10% and 15% of patients. Conclusions Measurement of creatinine was common among all patients following AKI. However, patients with AKI were infrequently monitored with assessments of quantitative proteinuria or mineral metabolism disorder, even for patients with baseline kidney disease. PMID:25117447

  9. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  10. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  11. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  12. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  13. Mars Science Laboratory Boot Robustness Testing

    NASA Technical Reports Server (NTRS)

    Banazadeh, Payam; Lam, Danny

    2011-01-01

    Mars Science Laboratory (MSL) is one of the most complex spacecrafts in the history of mankind. Due to the nature of its complexity, a large number of flight software (FSW) requirements have been written for implementation. In practice, these requirements necessitate very complex and very precise flight software with no room for error. One of flight software's responsibilities is to be able to boot up and check the state of all devices on the spacecraft after the wake up process. This boot up and initialization is crucial to the mission success since any misbehavior of different devices needs to be handled through the flight software. I have created a test toolkit that allows the FSW team to exhaustively test the flight software under variety of different unexpected scenarios and validate that flight software can handle any situation after booting up. The test includes initializing different devices on spacecraft to different configurations and validate at the end of the flight software boot up that the flight software has initialized those devices to what they are suppose to be in that particular scenario.

  14. Mars Science Laboratory Boot Robustness Testing

    NASA Technical Reports Server (NTRS)

    Banazadeh, Payam; Lam, Danny

    2011-01-01

    Mars Science Laboratory (MSL) is one of the most complex spacecrafts in the history of mankind. Due to the nature of its complexity, a large number of flight software (FSW) requirements have been written for implementation. In practice, these requirements necessitate very complex and very precise flight software with no room for error. One of flight software's responsibilities is to be able to boot up and check the state of all devices on the spacecraft after the wake up process. This boot up and initialization is crucial to the mission success since any misbehavior of different devices needs to be handled through the flight software. I have created a test toolkit that allows the FSW team to exhaustively test the flight software under variety of different unexpected scenarios and validate that flight software can handle any situation after booting up. The test includes initializing different devices on spacecraft to different configurations and validate at the end of the flight software boot up that the flight software has initialized those devices to what they are suppose to be in that particular scenario.

  15. TRITIUM LABORATORY, TRA666, INTERIOR. HYDRAULIC TEST FACILITY. INSIDE LABORATORY 103. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TRITIUM LABORATORY, TRA-666, INTERIOR. HYDRAULIC TEST FACILITY. INSIDE LABORATORY 103. CAMERA FACES NORTH. INL NEGATIVE NO. HD46-24-1. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  16. Optimizing tuberculosis testing for basic laboratories.

    PubMed

    Ramos, Eric; Schumacher, Samuel G; Siedner, Mark; Herrera, Beatriz; Quino, Willi; Alvarado, Jessica; Montoya, Rosario; Grandjean, Louis; Martin, Laura; Sherman, Jonathan M; Gilman, Robert H; Evans, Carlton A

    2010-10-01

    Optimal tuberculosis testing usually involves sputum centrifugation followed by broth culture. However, centrifuges are biohazardous and scarce in the resource-limited settings where most tuberculosis occurs. To optimize tuberculosis testing for these settings, centrifugation of 111 decontaminated sputum samples was compared with syringe-aspiration through polycarbonate membrane-filters that were then cultured in broth. To reduce the workload of repeated microscopic screening of broth cultures for tuberculosis growth, the colorimetric redox indicator 2,3-diphenyl-5-(2-thienyl) tetrazolium chloride was added to the broth, which enabled naked-eye detection of culture positivity. This combination of filtration and colorimetric growth-detection gave similar results to sputum centrifugation followed by culture microscopy regarding mean colony counts (43 versus 48; P = 0.6), contamination rates (0.9% versus 1.8%; P = 0.3), and sensitivity (94% versus 95%; P = 0.7), suggesting equivalency of the two methods. By obviating centrifugation and repeated microscopic screening of cultures, this approach may constitute a more appropriate technology for rapid and sensitive tuberculosis diagnosis in basic laboratories.

  17. Optimizing Tuberculosis Testing for Basic Laboratories

    PubMed Central

    Ramos, Eric; Schumacher, Samuel G.; Siedner, Mark; Herrera, Beatriz; Quino, Willi; Alvarado, Jessica; Montoya, Rosario; Grandjean, Louis; Martin, Laura; Sherman, Jonathan M.; Gilman, Robert H.; Evans, Carlton A.

    2010-01-01

    Optimal tuberculosis testing usually involves sputum centrifugation followed by broth culture. However, centrifuges are biohazardous and scarce in the resource-limited settings where most tuberculosis occurs. To optimize tuberculosis testing for these settings, centrifugation of 111 decontaminated sputum samples was compared with syringe-aspiration through polycarbonate membrane-filters that were then cultured in broth. To reduce the workload of repeated microscopic screening of broth cultures for tuberculosis growth, the colorimetric redox indicator 2,3-diphenyl-5-(2-thienyl) tetrazolium chloride was added to the broth, which enabled naked-eye detection of culture positivity. This combination of filtration and colorimetric growth-detection gave similar results to sputum centrifugation followed by culture microscopy regarding mean colony counts (43 versus 48; P = 0.6), contamination rates (0.9% versus 1.8%; P = 0.3), and sensitivity (94% versus 95%; P = 0.7), suggesting equivalency of the two methods. By obviating centrifugation and repeated microscopic screening of cultures, this approach may constitute a more appropriate technology for rapid and sensitive tuberculosis diagnosis in basic laboratories. PMID:20889887

  18. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  19. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  20. 18. Interior view of HVAC room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Interior view of HVAC room in Components Test Laboratory (T-27), showing northwest corner. Photograph shows upgraded instrumentation, piping, and technological modifications for HVAC system installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  1. 19. Interior view of HVAC room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Interior view of HVAC room in Components Test Laboratory (T-27), looking toward east wall. Photograph shows upgraded instrumentation, machinery, and technological modifications for HVAC system installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  2. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  3. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  4. 11. Interior view of control room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Interior view of control room in Components Test Laboratory (T-27), looking north. Photograph shows upgraded instrumentation, piping, and technological modifications installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  5. The mass storage testing laboratory at GSFC

    NASA Technical Reports Server (NTRS)

    Venkataraman, Ravi; Williams, Joel; Michaud, David; Gu, Heng; Kalluri, Atri; Hariharan, P. C.; Kobler, Ben; Behnke, Jeanne; Peavey, Bernard

    1998-01-01

    Industry-wide benchmarks exist for measuring the performance of processors (SPECmarks), and of database systems (Transaction Processing Council). Despite storage having become the dominant item in computing and IT (Information Technology) budgets, no such common benchmark is available in the mass storage field. Vendors and consultants provide services and tools for capacity planning and sizing, but these do not account for the complete set of metrics needed in today's archives. The availability of automated tape libraries, high-capacity RAID systems, and high- bandwidth interconnectivity between processor and peripherals has led to demands for services which traditional file systems cannot provide. File Storage and Management Systems (FSMS), which began to be marketed in the late 80's, have helped to some extent with large tape libraries, but their use has introduced additional parameters affecting performance. The aim of the Mass Storage Test Laboratory (MSTL) at Goddard Space Flight Center is to develop a test suite that includes not only a comprehensive check list to document a mass storage environment but also benchmark code. Benchmark code is being tested which will provide measurements for both baseline systems, i.e. applications interacting with peripherals through the operating system services, and for combinations involving an FSMS. The benchmarks are written in C, and are easily portable. They are initially being aimed at the UNIX Open Systems world. Measurements are being made using a Sun Ultra 170 Sparc with 256MB memory running Solaris 2.5.1 with the following configuration: 4mm tape stacker on SCSI 2 Fast/Wide; 4GB disk device on SCSI 2 Fast/Wide; and Sony Petaserve on Fast/Wide differential SCSI 2.

  6. The mass storage testing laboratory at GSFC

    NASA Technical Reports Server (NTRS)

    Venkataraman, Ravi; Williams, Joel; Michaud, David; Gu, Heng; Kalluri, Atri; Hariharan, P. C.; Kobler, Ben; Behnke, Jeanne; Peavey, Bernard

    1998-01-01

    Industry-wide benchmarks exist for measuring the performance of processors (SPECmarks), and of database systems (Transaction Processing Council). Despite storage having become the dominant item in computing and IT (Information Technology) budgets, no such common benchmark is available in the mass storage field. Vendors and consultants provide services and tools for capacity planning and sizing, but these do not account for the complete set of metrics needed in today's archives. The availability of automated tape libraries, high-capacity RAID systems, and high- bandwidth interconnectivity between processor and peripherals has led to demands for services which traditional file systems cannot provide. File Storage and Management Systems (FSMS), which began to be marketed in the late 80's, have helped to some extent with large tape libraries, but their use has introduced additional parameters affecting performance. The aim of the Mass Storage Test Laboratory (MSTL) at Goddard Space Flight Center is to develop a test suite that includes not only a comprehensive check list to document a mass storage environment but also benchmark code. Benchmark code is being tested which will provide measurements for both baseline systems, i.e. applications interacting with peripherals through the operating system services, and for combinations involving an FSMS. The benchmarks are written in C, and are easily portable. They are initially being aimed at the UNIX Open Systems world. Measurements are being made using a Sun Ultra 170 Sparc with 256MB memory running Solaris 2.5.1 with the following configuration: 4mm tape stacker on SCSI 2 Fast/Wide; 4GB disk device on SCSI 2 Fast/Wide; and Sony Petaserve on Fast/Wide differential SCSI 2.

  7. Quality of HIV laboratory testing in Tanzania: a situation analysis.

    PubMed

    Mfinanga, G S; Mutayoba, B; Mbogo, G; Kahwa, A; Kimaro, G; Mhame, P P; Mwangi, C; Malecela, M N; Kitua, A Y

    2007-01-01

    Tanzania is scaling up prevention, treatment, care and support of individuals affected with HIV. There is therefore a need for high quality and reliable HIV infection testing and AIDS staging. The objective of this study was to assess laboratories capacities of services in terms of HIV testing and quality control. A baseline survey was conducted from December 2004 to February 2005 in 12 laboratories which were conveniently selected to represent all the zones of Tanzania. The questionnaires comprised of questions on laboratory particulars, internal and external quality control for HIV testing and quality control of reagents. Source and level of customer satisfaction of HIV test kits supply was established. Of 12 laboratories, nine used rapid tests for screening and two used rapid tests for diagnosis. In the 12 laboratories, four used double ELISA and five used single ELISA and three did not use ELISA. Confirmatory tests observed were Western Blot in three laboratories, DNA PCR in two laboratories, CD4 counting in seven laboratories, and viral load in two laboratories. Although all laboratories conducted quality control (QC) of the HIV kits, only two laboratories had Standard Operating Procedures (SOPs). Internal and external quality control (EQC) was done at varied proportions with the highest frequency of 55.6% (5/9) for internal quality control (IQC) for rapid tests and EQC for ELISA, and the lowest frequency of 14.3% (1/ 7) for IQC for CD4 counting. None of the nine laboratories which conducted QC for reagents used for rapid tests and none of the five which performed IQC and EQC had SOPs. HIV kits were mainly procured by the Medical Store Department and most of laboratories were not satisfied with the delay in procurement procedures. Most of the laboratories used rapid tests only, while some used both rapid tests and ELISA method for HIV testing. In conclusion, the survey revealed inadequacy in Good Laboratory Practice and poor laboratory quality control process

  8. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by this...

  9. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  10. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  11. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  12. Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing.

    PubMed

    Schmiegel, Wolff; Scott, Rodney J; Dooley, Susan; Lewis, Wendy; Meldrum, Cliff J; Pockney, Peter; Draganic, Brian; Smith, Steve; Hewitt, Chelsee; Philimore, Hazel; Lucas, Amanda; Shi, Elva; Namdarian, Kateh; Chan, Timmy; Acosta, Danilo; Ping-Chang, Su; Tannapfel, Andrea; Reinacher-Schick, Anke; Uhl, Waldemar; Teschendorf, Christian; Wolters, Heiner; Stern, Josef; Viebahn, Richard; Friess, Helmut; Janssen, Klaus-Peter; Nitsche, Ulrich; Slotta-Huspenina, Julia; Pohl, Michael; Vangala, Deepak; Baraniskin, Alexander; Dockhorn-Dworniczak, Barbara; Hegewisch-Becker, Susanne; Ronga, Philippe; Edelstein, Daniel L; Jones, Frederick S; Hahn, Stephan; Fox, Stephen B

    2017-02-01

    An accurate blood-based RAS mutation assay to determine eligibility of metastatic colorectal cancer (mCRC) patients for anti-EGFR therapy would benefit clinical practice by better informing decisions to administer treatment independent of tissue availability. The objective of this study was to determine the level of concordance between plasma and tissue RAS mutation status in patients with mCRC to gauge whether blood-based RAS mutation testing is a viable alternative to standard-of-care RAS tumor testing. RAS testing was performed on plasma samples from newly diagnosed metastatic patients, or from recurrent mCRC patients using the highly sensitive digital PCR technology, BEAMing (beads, emulsions, amplification, and magnetics), and compared with DNA sequencing data of respective FFPE (formalin-fixed paraffin-embedded) tumor samples. Discordant tissue RAS results were re-examined by BEAMing, if possible. The prevalence of RAS mutations detected in plasma (51%) vs. tumor (53%) was similar, in accord with the known prevalence of RAS mutations observed in mCRC patient populations. The positive agreement between plasma and tumor RAS results was 90.4% (47/52), the negative agreement was 93.5% (43/46), and the overall agreement (concordance) was 91.8% (90/98). The high concordance of plasma and tissue results demonstrates that blood-based RAS mutation testing is a viable alternative to tissue-based RAS testing.

  13. Inverter testing at Sandia National Laboratories

    SciTech Connect

    Ginn, J.W.; Bonn, R.H.; Sittler, G.

    1997-04-01

    Inverters are key building blocks of photovoltaic (PV) systems that produce ac power. The balance of systems (BOS) portion of a PV system can account for up to 50% of the system cost, and its reliable operation is essential for a successful PV system. As part of its BOS program, Sandia National Laboratories (SNL) maintains a laboratory wherein accurate electrical measurements of power systems can be made under a variety of conditions. This paper outlines the work that is done in that laboratory.

  14. [Recent advances in immunologic laboratory testing for rheumatic diseases].

    PubMed

    Akahoshi, Tohru

    2004-09-01

    Immunologic laboratory tests serve critical roles in the care of patients with various rheumatic diseases. These tests can provide relevant information of rheumatic diseases based on their immunopathophysiological condition. Although immunologic laboratory tests are quite useful for the determination of diagnosis and the estimation of disease activity, organ involvement and prognosis, they are frequently misused and resulted in an inappropriate diagnosis and treatment. Appropriate use of immunologic laboratory tests and accurate clinical interpretation of the test results can prevent false diagnosis and unnecessary treatment. In order to improve clinical care of patients with rheumatic diseases, clinicians caring patients with rheumatic disease should recognize meanings, characteristics and limitations of each result of immunologic laboratory testing. This article reviewed recent advances in immunologic laboratory testing such as antinuclear antibody, anti-DNA antibody and anti-neutrophil cytoplasmic antibody, and introduced guidelines for these testing. These guidelines based on evidences of EBM may contribute to the appropriate use of immunologic laboratory tests for rheumatic diseases.

  15. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Technology/National Voluntary Laboratory Accreditation Program (NIST/NVLAP); or (2) A laboratory accreditation body having a mutual recognition arrangement with NIST/NVLAP; or (3) An organization classified by the Department, pursuant to § 431.19, as an accreditation body. (b) NIST/NVLAP is under the auspices...

  16. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Technology/National Voluntary Laboratory Accreditation Program (NIST/NVLAP); or (2) A laboratory accreditation body having a mutual recognition arrangement with NIST/NVLAP; or (3) An organization classified by the Department, pursuant to § 431.19, as an accreditation body. (b) NIST/NVLAP is under the auspices...

  17. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Technology/National Voluntary Laboratory Accreditation Program (NIST/NVLAP); or (2) A laboratory accreditation body having a mutual recognition arrangement with NIST/NVLAP; or (3) An organization classified by the Department, pursuant to § 431.19, as an accreditation body. (b) NIST/NVLAP is under the auspices...

  18. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Technology/National Voluntary Laboratory Accreditation Program (NIST/NVLAP); or (2) A laboratory accreditation body having a mutual recognition arrangement with NIST/NVLAP; or (3) An organization classified by the Department, pursuant to § 431.19, as an accreditation body. (b) NIST/NVLAP is under the auspices...

  19. Laboratory tests used in US public health laboratories for sexually transmitted diseases, 2000.

    PubMed

    Dicker, Linda Webster; Mosure, Debra J; Steece, Richard; Stone, Katherine M

    2004-05-01

    Public health laboratories are a critical component of sexually transmitted disease (STD) control in the United States. The goal of this study was to describe the types and volume of STD tests performed in U.S. public health laboratories in 2000. A survey was mailed to 123 members of the Association of Public Health Laboratories. Eighty-one percent of 100 laboratories responded. Overall, 3294739 chlamydia tests and 3088142 gonorrhea tests were done; 62.4% of chlamydia tests and 63.6% of gonorrhea tests were DNA probes. Fifty-six percent of laboratories performed rapid plasma reagin (RPR) tests and 55% performed Venereal Disease Research Laboratory (VDRL) tests; the number of RPR tests performed was twice that of VDRL tests. Few laboratories used new technologies for bacterial vaginosis and trichomoniasis. Eighteen percent of laboratories performed herpes simplex virus serology; however, most used inaccurate tests. No laboratories performed human papillomavirus tests. This survey documents for the first time STD tests performed in U.S. public health laboratories.

  20. 5. AERIAL PHOTO OF THE COMPONENTS TEST LABORATORY DURING THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. AERIAL PHOTO OF THE COMPONENTS TEST LABORATORY DURING THE CONSTRUCTION OF THE EAST TEST AREA. 1955, FRED ORDWAY COLLECTION, U.S. SPACE AND ROCKET CENTER, HUNTSVILLE, AL. - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

  1. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has a...

  2. 10. Interior view of control room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Interior view of control room in Components Test Laboratory (T-27), looking east. The control room is located in the center of the building and abuts the Test Cell 8, 9, and 10 and equipment room wings. Photograph shows upgraded instrumentation, piping, and technological modifications installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  3. New technologies to improve laboratory testing

    NASA Astrophysics Data System (ADS)

    Burtis, C. A.

    Several core technologies that are having, or will have, an impact on the clinical laboratory are discussed. These include instrument-related technologies such as computer technology, chemometrics, robotics, sensors, and biological technologies such as cell fusion and recombinant DNA.

  4. Integration of laboratory and process testing data

    PubMed Central

    Tyszkiewicz, Michael

    1995-01-01

    The author describes ACS Inc.'s Pro-LIMS system which integrates laboratory and process procedures. The system has been shown to be an important toolfor quality assurance in the process manufacturing industry. PMID:18924782

  5. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  6. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  7. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  8. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  9. Impact of Laboratory Test Use Strategies in a Turkish Hospital.

    PubMed

    Yılmaz, Fatma Meriç; Kahveci, Rabia; Aksoy, Altan; Özer Kucuk, Emine; Akın, Tezcan; Mathew, Joseph Lazar; Meads, Catherine; Zengin, Nurullah

    2016-01-01

    Eliminating unnecessary laboratory tests is a good way to reduce costs while maintain patient safety. The aim of this study was to define and process strategies to rationalize laboratory use in Ankara Numune Training and Research Hospital (ANH) and calculate potential savings in costs. A collaborative plan was defined by hospital managers; joint meetings with ANHTA and laboratory professors were set; the joint committee invited relevant staff for input, and a laboratory efficiency committee was created. Literature was reviewed systematically to identify strategies used to improve laboratory efficiency. Strategies that would be applicable in local settings were identified for implementation, processed, and the impact on clinical use and costs assessed for 12 months. Laboratory use in ANH differed enormously among clinics. Major use was identified in internal medicine. The mean number of tests per patient was 15.8. Unnecessary testing for chloride, folic acid, free prostate specific antigen, hepatitis and HIV testing were observed. Test panel use was pinpointed as the main cause of overuse of the laboratory and the Hospital Information System test ordering page was reorganized. A significant decrease (between 12.6-85.0%) was observed for the tests that were taken to an alternative page on the computer screen. The one year study saving was equivalent to 371,183 US dollars. Hospital-based committees including laboratory professionals and clinicians can define hospital based problems and led to a standardized approach to test use that can help clinicians reduce laboratory costs through appropriate use of laboratory tests.

  10. [How do hospital clinical laboratories and laboratory testing companies cooperate and build reciprocal relations?].

    PubMed

    Kawano, Seiji

    2014-12-01

    As the 2nd Joint Symposium of the Japanese Society of Laboratory Medicine and the Japanese Association of Laboratory Pathologists, the symposium on clinical test out-sourcing and branch laboratories was held at the 60th General Meeting of the Japanese Society of Laboratory Medicine on November 2nd, 2013 in Kobe. For the symposium, we conducted a questionnaire survey on the usage of clinical test out-sourcing and the introduction of branch laboratories to clinical laboratories of Japanese university hospitals, both private and public, between July 25th and August 20th, 2013. Seventy-two hospitals responded to the questionnaire survey, consisting of 41 public medical school hospitals and 31 private ones. According to the survey, the selection of each clinical test for out-sourcing was mainly determined by the capacities of hospital clinical laboratories and their equipment, as well as the profitability of each test. The main concerns of clinical laboratory members of university hospitals involved the continuity of measurement principles, traceability, and standardization of reference values for each test. They strongly requested the interchangeability and computerization of test data between laboratory testing companies. A branch laboratory was introduced to six hospitals, all of which were private medical college hospitals, out of 72 university hospitals, and eight of the other hospitals were open to its introduction. The merits and demerits of introducing a branch laboratory were also discussed. (Review).

  11. Transportable Emissions Testing Laboratory for Alternative Vehicles Emissions Testing

    SciTech Connect

    Clark, Nigel

    2012-01-31

    The overall objective of this project was to perform research to quantify and improve the energy efficiency and the exhaust emissions reduction from advanced technology vehicles using clean, renewable and alternative fuels. Advanced vehicle and alternative fuel fleets were to be identified, and selected vehicles characterized for emissions and efficiency. Target vehicles were to include transit buses, school buses, vocational trucks, delivery trucks, and tractor-trailers. Gaseous species measured were to include carbon monoxide, carbon dioxide, oxides of nitrogen, hydrocarbons, and particulate matter. An objective was to characterize particulate matter more deeply than by mass. Accurate characterization of efficiency and emissions was to be accomplished using a state-of-the-art portable emissions measurement system and an accompanying chassis dynamometer available at West Virginia University. These two units, combined, are termed the Transportable Laboratory. An objective was to load the vehicles in a real-world fashion, using coast down data to establish rolling resistance and wind drag, and to apply the coast down data to the dynamometer control. Test schedules created from actual vehicle operation were to be employed, and a specific objective of the research was to assess the effect of choosing a test schedule which the subject vehicle either cannot follow or can substantially outperform. In addition the vehicle loading objective was to be met better with an improved flywheel system.

  12. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in accordance...

  13. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in accordance...

  14. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  15. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  16. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  17. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability of...

  18. Design and Laboratory Testing of a Prototype Linear Temperature Sensor

    DTIC Science & Technology

    1982-07-01

    Report DT-8203-01 Dynamics Technology, Inc. ’-4 DESIGN AND LABORATORY TESTING OF A PROTOTYPE LINEAR TEMPERATURE SENSOR C. Michael Dube and Christian...PERIOD COVERED DESIGN AND LABORATORY TESTING OF A PROTOTYPE FINAL REPORT LINEAR TEMPERATURE SENSOR 1 January 82 - 30 June 1982 7. AUTOMIGHOR. EPRTNUBE...discusses the basic theory, design, and laboratory testing of a A p.ototype linear temperature sensor (or "line sensor "), which is an instru- m1ent for

  19. New technologies to improve laboratory testing

    SciTech Connect

    Burtis, C.A.

    1985-01-01

    Several core technologies that are having, or will have, an impact on the clinical laboratory are discussed. These include instrument-related technologies such as computer technology, chemometrics, robotics, sensors, and biological technologies such as cell fusion and recombinant DNA. 79 references, 14 figures. (ACR)

  20. Clinical laboratory test prices in Zimbabwe: A case of profiteering?

    PubMed

    Musarurwa, C; Nyamayaro, T; Mujaji, W B; Matarira, H T; Gomo, Z A R

    2012-01-01

    To compare the prices charged for clinical laboratory tests in Zimbabwean institutions with those of similar institutions abroad. An online analytical cross sectional study was conducted. An online survey. We did an online survey of clinical laboratories that published prices of the tests offered on their websites. We also extracted price information from documents published by fees regulatory authorities. Laboratory test prices for independent institutions, Laboratory test prices for State institutions. Overally for all countries, laboratory test prices were lower in state laboratories compared to the independent laboratories. In Zimbabwe, state laboratories generally charged about 50% of the independent laboratory tariff for most tests. However prices from both Zimbabwean institutions were generally much higher than those of the comparison countries (United Kingdom, South Africa, India, United States of America and New Zealand). Prices of laboratory tests are indeed higher in Zimbabwean institutions compared to other centres abroad. These higher prices could be attributed to challenges in consumable procurement logistics. We also present measures that could be put in place to reduce the costs and therefore prices.

  1. Methods for Testing the Mars Science Laboratory's Landing Radar

    NASA Technical Reports Server (NTRS)

    Chapin, Elaine; Grando, Maurio B.; Hamilton, Gary A.; Pak, Kyung S.; Pollard, Brian D.; Shaffer, Scott J.; Wu, Chialin

    2013-01-01

    The Mars Science Laboratory's rover named Curiosity successfully landed on Mars on August 6, 2012. One component of the Mars Science Laboratory (MSL) Entry, Descent, and Landing (EDL) system was the Terminal Descent Sensor (TDS) landing radar. In this paper we describe laboratory testing of this radar performed before launch.

  2. 9. Exterior view, Test Cell 7, Systems Integration Laboratory Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Exterior view, Test Cell 7, Systems Integration Laboratory Building (T-28), looking southwest. The enclosure discussed in CO-88-B-8 is at the right. - Air Force Plant PJKS, Systems Integration Laboratory, Systems Integration Laboratory Building, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  3. Methods for Testing the Mars Science Laboratory's Landing Radar

    NASA Technical Reports Server (NTRS)

    Chapin, Elaine; Grando, Maurio B.; Hamilton, Gary A.; Pak, Kyung S.; Pollard, Brian D.; Shaffer, Scott J.; Wu, Chialin

    2013-01-01

    The Mars Science Laboratory's rover named Curiosity successfully landed on Mars on August 6, 2012. One component of the Mars Science Laboratory (MSL) Entry, Descent, and Landing (EDL) system was the Terminal Descent Sensor (TDS) landing radar. In this paper we describe laboratory testing of this radar performed before launch.

  4. Workgroup for Hydraulic laboratory Testing and Verification of Hydroacoustic Instrumentation

    USGS Publications Warehouse

    Fulford, Janice M.; Armstrong, Brandy N.; Thibodeaux, Kirk G.

    2015-01-01

    An international workgroup was recently formed for hydraulic laboratory testing and verification of hydroacoustic instrumentation used for water velocity measurements. The activities of the workgroup have included one face to face meeting, conference calls and an inter-laboratory exchange of two acoustic meters among participating laboratories. Good agreement was found among four laboratories at higher tow speeds and poorer agreement at the lowest tow speed.

  5. Estimating Abrasivity of Rock by Laboratory and In Situ Tests

    NASA Astrophysics Data System (ADS)

    Okubo, S.; Fukui, K.; Nishimatsu, Y.

    2011-03-01

    The degree to which a rock abrades another rock is called its "abrasivity". Laboratory tests of abrasivity can be broadly divided into four kinds: drilling, rubbing, turning-operation and tumbling tests. The present study was initiated 30 years ago with the objective of investigating and developing methods for measuring rock abrasivity, and making some contribution towards understanding the relationships between the above test methods. Within the range of tests conducted, the turning-operation test turned out to be superior to the drilling test, albeit slightly, in terms of practicality. We have also conducted in situ tests using rock drills for the last 20 years. The results of those tests have been investigated and compared with the results of laboratory tests. There is a large degree of scatter in the data on gauge loss in button bits, which has obscured any correlations with laboratory data. Some correlations were found between height loss in button bits and laboratory findings.

  6. Point-of-Care Test Equipment for Flexible Laboratory Automation.

    PubMed

    You, Won Suk; Park, Jae Jun; Jin, Sung Moon; Ryew, Sung Moo; Choi, Hyouk Ryeol

    2014-08-01

    Blood tests are some of the core clinical laboratory tests for diagnosing patients. In hospitals, an automated process called total laboratory automation, which relies on a set of sophisticated equipment, is normally adopted for blood tests. Noting that the total laboratory automation system typically requires a large footprint and significant amount of power, slim and easy-to-move blood test equipment is necessary for specific demands such as emergency departments or small-size local clinics. In this article, we present a point-of-care test system that can provide flexibility and portability with low cost. First, the system components, including a reagent tray, dispensing module, microfluidic disk rotor, and photometry scanner, and their functions are explained. Then, a scheduler algorithm to provide a point-of-care test platform with an efficient test schedule to reduce test time is introduced. Finally, the results of diagnostic tests are presented to evaluate the system. © 2014 Society for Laboratory Automation and Screening.

  7. Predicting Tests Ordered in Hospital Laboratories using Generalized Linear Modeling.

    PubMed

    Leaven, Laquanda T

    2016-01-01

    Laboratory services in healthcare systems play a vital role in inpatient care. Most hospital laboratories are facing the challenge of reducing cost and improving service quality. The author focuses on identifying test order patterns in a laboratory for a large urban hospital. The data collected from this facility consists of all tests ordered over a three-month time frame and contains test orders for approximately 17,500 patients. Poisson and negative binomial regression models are used to determine how well patient characteristics (patient length of stay and the medical units in which patients are placed) will predict the number of tests being ordered. The test order prediction model developed in this study will aid the management and phlebotomists in the hospital laboratory in securing methods to satisfy the test order demand. By implementing the recommendations of this study, hospital laboratories should see significant improvements in phlebotomist productivity and resource utilization, implementation of which could result in cost savings.

  8. External quality assessment of medical laboratories in Croatia: preliminary evaluation of post-analytical laboratory testing.

    PubMed

    Krleza, Jasna Lenicek; Dorotic, Adrijana; Grzunov, Ana

    2017-02-15

    Proper standardization of laboratory testing requires assessment of performance after the tests are performed, known as the post-analytical phase. A nationwide external quality assessment (EQA) scheme implemented in Croatia in 2014 includes a questionnaire on post-analytical practices, and the present study examined laboratory responses in order to identify current post-analytical phase practices and identify areas for improvement. In four EQA exercises between September 2014 and December 2015, 145-174 medical laboratories across Croatia were surveyed using the Module 11 questionnaire on the post-analytical phase of testing. Based on their responses, the laboratories were evaluated on four quality indicators: turnaround time (TAT), critical values, interpretative comments and procedures in the event of abnormal results. Results were presented as absolute numbers and percentages. Just over half of laboratories (56.3%) monitored TAT. Laboratories varied substantially in how they dealt with critical values. Most laboratories (65-97%) issued interpretative comments with test results. One third of medical laboratories (30.6-33.3%) issued abnormal test results without confirming them in additional testing. Our results suggest that the nationwide post-analytical EQA scheme launched in 2014 in Croatia has yet to be implemented to the full. To close the gaps between existing recommendations and laboratory practice, laboratory professionals should focus on ensuring that TAT is monitored and lists of critical values are established within laboratories. Professional bodies/institutions should focus on clarify and harmonized rules to standardized practices and applied for adding interpretative comments to laboratory test results and for dealing with abnormal test results.

  9. External quality assessment of medical laboratories in Croatia: preliminary evaluation of post-analytical laboratory testing

    PubMed Central

    Krleza, Jasna Lenicek; Dorotic, Adrijana; Grzunov, Ana

    2017-01-01

    Introduction Proper standardization of laboratory testing requires assessment of performance after the tests are performed, known as the post-analytical phase. A nationwide external quality assessment (EQA) scheme implemented in Croatia in 2014 includes a questionnaire on post-analytical practices, and the present study examined laboratory responses in order to identify current post-analytical phase practices and identify areas for improvement. Materials and methods In four EQA exercises between September 2014 and December 2015, 145-174 medical laboratories across Croatia were surveyed using the Module 11 questionnaire on the post-analytical phase of testing. Based on their responses, the laboratories were evaluated on four quality indicators: turnaround time (TAT), critical values, interpretative comments and procedures in the event of abnormal results. Results were presented as absolute numbers and percentages. Results Just over half of laboratories (56.3%) monitored TAT. Laboratories varied substantially in how they dealt with critical values. Most laboratories (65-97%) issued interpretative comments with test results. One third of medical laboratories (30.6-33.3%) issued abnormal test results without confirming them in additional testing. Conclusion Our results suggest that the nationwide post-analytical EQA scheme launched in 2014 in Croatia has yet to be implemented to the full. To close the gaps between existing recommendations and laboratory practice, laboratory professionals should focus on ensuring that TAT is monitored and lists of critical values are established within laboratories. Professional bodies/institutions should focus on clarify and harmonized rules to standardized practices and applied for adding interpretative comments to laboratory test results and for dealing with abnormal test results. PMID:28392737

  10. National Media Laboratory media testing results

    NASA Technical Reports Server (NTRS)

    Mularie, William

    1993-01-01

    The government faces a crisis in data storage, analysis, archive, and communication. The sheer quantity of data being poured into the government systems on a daily basis is overwhelming systems ability to capture, analyze, disseminate, and store critical information. Future systems requirements are even more formidable: with single government platforms having data rate of over 1 Gbit/sec, greater than Terabyte/day storage requirements, and with expected data archive lifetimes of over 10 years. The charter of the National Media Laboratory (NML) is to focus the resources of industry, government, and academia on government needs in the evaluation, development, and field support of advanced recording systems.

  11. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Testing by Customs laboratory. 151.54 Section 151.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance...

  12. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  13. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  14. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  15. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control. Representative...

  16. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control. Representative...

  17. Total laboratory automation: Do stat tests still matter?

    PubMed

    Dolci, Alberto; Giavarina, Davide; Pasqualetti, Sara; Szőke, Dominika; Panteghini, Mauro

    2017-04-05

    During the past decades the healthcare systems have rapidly changed and today hospital care is primarily advocated for critical patients and acute treatments, for which laboratory test results are crucial and need to be always reported in predictably short turnaround time (TAT). Laboratories in the hospital setting can face this challenge by changing their organization from a compartmentalized laboratory department toward a decision making-based laboratory department. This requires the implementation of a core laboratory, that exploits total laboratory automation (TLA) using technological innovation in analytical platforms, track systems and information technology, including middleware, and a number of satellite specialized laboratory sections cooperating with care teams for specific medical conditions. In this laboratory department model, the short TAT for all first-line tests performed by TLA in the core laboratory represents the key paradigm, where no more stat testing is required because all samples are handled in real-time and (auto)validated results dispatched in a time that fulfills clinical needs. To optimally reach this goal, laboratories should be actively involved in managing all the steps covering the total examination process, speeding up also extra-laboratory phases, such sample delivery. Furthermore, to warrant effectiveness and not only efficiency, all the processes, e.g. specimen integrity check, should be managed by middleware through a predefined set of rules defined in light of the clinical governance.

  18. Laboratory Tests - Multiple Languages: MedlinePlus

    MedlinePlus

    ... Arabic (العربية) Chinese - Simplified (简体中文) Chinese - Traditional (繁體中文) French (français) Hindi (हिन्दी) Japanese (日本語) Khmer (Khmer) ... Chinese - Traditional) PDF Chinese Community Health Resource Center French (français) 24-Hour Urine Test Test d'urine ...

  19. Human Papillomavirus Laboratory Testing: the Changing Paradigm

    PubMed Central

    2016-01-01

    SUMMARY High-risk human papillomaviruses (HPVs) cause essentially all cervical cancers, most anal and oropharyngeal cancers, and some vaginal, vulvar, and penile cancers. Improved understanding of the pathogenesis of infection and the availability of newer tests are changing the approach to screening and diagnosis. Molecular tests to detect DNA from the most common high-risk HPVs are FDA approved for use in conjunction with cytology in cervical cancer screening programs. More-specific tests that detect RNA from high-risk HPV types are now also available. The use of molecular tests as the primary screening tests is being adopted in some areas. Genotyping to identify HPV16 and -18 has a recommended role in triaging patients for colposcopy who are high-risk HPV positive but have normal cytology. There are currently no recommended screening methods for anal, vulvar, vaginal, penile, or oropharyngeal HPV infections. HPV testing has limited utility in patients at high risk for anal cancer, but p16 immunohistochemistry is recommended to clarify lesions in tissue biopsy specimens that show moderate dysplasia or precancer mimics. HPV testing is recommended for oropharyngeal squamous cell tumors as a prognostic indicator. Ongoing research will help to improve the content of future guidelines for screening and diagnostic testing. PMID:26912568

  20. Contextualizing Laboratory Administered Aural Comprehension Tests

    ERIC Educational Resources Information Center

    Seliger, Herbert W.; Whiteson, Valerie

    1975-01-01

    An experimental test consisting of dialogue with intermittent pauses for responses and a white noise accompaniment was given to non-English speakers who were candidates for admission to the English Department at Bar Ilan University in order to evaluate aural comprehension. Development of the test and results are reported. (RM)

  1. A Cautionary Note: Ceriodaphnia dubia Inter-Laboratory Test Variability.

    PubMed

    Pacholski, Laura; Chapman, Peter; Hood, Alexandra; Peters, Michelle

    2017-01-01

    An inter-laboratory comparison of the three-brood survival and reproduction Ceriodaphnia dubia toxicity test was conducted involving three toxicity testing laboratories. This comparison was initiated due to sporadic toxicity with this test related to discharge of a mine effluent, which some regulators believed indicated adverse effects in the receiving environment. One mine effluent and two receiving water samples were evaluated. There were no adverse effects on C. dubia survival in any tests. However, sublethal effects on reproduction (i.e., the IC25; the concentration that causes a 25 % inhibitory effect in the measured sublethal endpoint) ranged from 35 % to >100 % among all test treatments. All laboratories were certified for this test and followed established procedures. Dilute mineral water appears to be the best medium for culturing, dilution, and control water. Variability in the C. dubia laboratory toxicity test should not be mistaken for adverse effects in receiving environments.

  2. Impact of Laboratory Test Use Strategies in a Turkish Hospital

    PubMed Central

    Yılmaz, Fatma Meriç; Kahveci, Rabia; Aksoy, Altan; Özer Kucuk, Emine; Akın, Tezcan; Mathew, Joseph Lazar; Meads, Catherine; Zengin, Nurullah

    2016-01-01

    Objectives Eliminating unnecessary laboratory tests is a good way to reduce costs while maintain patient safety. The aim of this study was to define and process strategies to rationalize laboratory use in Ankara Numune Training and Research Hospital (ANH) and calculate potential savings in costs. Methods A collaborative plan was defined by hospital managers; joint meetings with ANHTA and laboratory professors were set; the joint committee invited relevant staff for input, and a laboratory efficiency committee was created. Literature was reviewed systematically to identify strategies used to improve laboratory efficiency. Strategies that would be applicable in local settings were identified for implementation, processed, and the impact on clinical use and costs assessed for 12 months. Results Laboratory use in ANH differed enormously among clinics. Major use was identified in internal medicine. The mean number of tests per patient was 15.8. Unnecessary testing for chloride, folic acid, free prostate specific antigen, hepatitis and HIV testing were observed. Test panel use was pinpointed as the main cause of overuse of the laboratory and the Hospital Information System test ordering page was reorganized. A significant decrease (between 12.6–85.0%) was observed for the tests that were taken to an alternative page on the computer screen. The one year study saving was equivalent to 371,183 US dollars. Conclusion Hospital-based committees including laboratory professionals and clinicians can define hospital based problems and led to a standardized approach to test use that can help clinicians reduce laboratory costs through appropriate use of laboratory tests. PMID:27077653

  3. Laboratory results of the AOF system testing

    NASA Astrophysics Data System (ADS)

    Kolb, Johann; Madec, Pierre-Yves; Arsenault, Robin; Oberti, Sylvain; Paufique, Jérôme; La Penna, Paolo; Ströbele, Stefan; Donaldson, Robert; Soenke, Christian; Suárez Valles, Marcos; Kiekebusch, Mario; Argomedo, Javier; Le Louarn, Miska; Vernet, Elise; Haguenauer, Pierre; Duhoux, Philippe; Aller-Carpentier, Emmanuel; Valenzuela, Jose Javier; Guerra, Juan Carlos

    2016-07-01

    For two years starting in February 2014, the AO modules GRAAL for HAWK-I and GALACSI for MUSE of the Adaptive Optics Facility project have undergone System Testing at ESO's Headquarters. They offer four different modes: NGS SCAO, LGS GLAO in the IR, LGS GLAO and LTAO in the visible. A detailed characterization of those modes was made possible by the existence of ASSIST, a test bench emulating an adaptive VLT including the Deformable Secondary Mirror, a star simulator and turbulence generator and a VLT focal plane re-imager. This phase aimed at validating all the possible components and loops of the AO modules before installation at the actual VLT that comprises the added complexity of real LGSs, a harsher non-reproducible environment and the adaptive telescope control. In this paper we present some of the major results obtained and challenges encountered during the phase of System Tests, like the preparation of the Acquisition sequence, the testing of the Jitter loop, the performance optimization in GLAO and the offload of low-order modes from the DSM to the telescope (restricted to the M2 hexapod). The System Tests concluded with the successful acceptance, shipping, installation and first commissioning of GRAAL in 2015 as well as the acceptance and shipping of GALACSI, ready for installation and commissioning early 2017.

  4. Laboratory test of a pyramid wavefront sensor

    NASA Astrophysics Data System (ADS)

    Esposito, Simone; Feeney, Orla; Riccardi, Armando

    2000-07-01

    A laboratory characterization of a new wavefront sensor for adaptive optics applications called a pyramid sensor is presented. This characterization is aimed at establishing the sensor accuracy and sensitivity. To investigate the operation of the sensor in low and high order correction adaptive optics systems, its behavior for different amplitudes of incoming wavefront aberrations is studied. The sensor characterization is carried out using a two arm optical set-up that allows the comparison of the PS measurements with those of a commercial Fizeau interferometer. This is done when a certain aberration is introduced into the optical path of both instruments via a deformable mirror. The experimental data are analyzed and discussed using both geometrical and diffractive optics theory. The closed loop sensor accuracy is investigated experimentally and demonstrates closed loop wavefront correction down to 30 nm root mean square for starting aberrations whose root mean square ranges from 170 nm to 300 nm. Modal noise propagation coefficients are determined and are compared with Shack-Hartmann sensor coefficients.

  5. Laboratory Test of Reciprocating Internal Combustion Engines

    DTIC Science & Technology

    2016-02-04

    Control Module (ECM) torque horsepower engine speed boost turbocharger throttle injector power curve...factors can be related to physical space or required range of operation. Most research, development, and testing applications will require four...Friction brake Special purpose applications for very high torques at low speed. Limited speed range. Air brake Cheap, very little support service

  6. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining Efficiency..., and Lab Bulletin LB-42-2009, Efficiency of Electric Motors Program, (referenced for guidance only, see § 431.14) present the technical requirements of NVLAP for the Efficiency of Electric Motors field...

  7. Using Machine Learning to Predict Laboratory Test Results.

    PubMed

    Luo, Yuan; Szolovits, Peter; Dighe, Anand S; Baron, Jason M

    2016-06-01

    While clinical laboratories report most test results as individual numbers, findings, or observations, clinical diagnosis usually relies on the results of multiple tests. Clinical decision support that integrates multiple elements of laboratory data could be highly useful in enhancing laboratory diagnosis. Using the analyte ferritin in a proof of concept, we extracted clinical laboratory data from patient testing and applied a variety of machine-learning algorithms to predict ferritin test results using the results from other tests. We compared predicted with measured results and reviewed selected cases to assess the clinical value of predicted ferritin. We show that patient demographics and results of other laboratory tests can discriminate normal from abnormal ferritin results with a high degree of accuracy (area under the curve as high as 0.97, held-out test data). Case review indicated that predicted ferritin results may sometimes better reflect underlying iron status than measured ferritin. These findings highlight the substantial informational redundancy present in patient test results and offer a potential foundation for a novel type of clinical decision support aimed at integrating, interpreting, and enhancing the diagnostic value of multianalyte sets of clinical laboratory test results. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. Laboratory-scale integrated ARP filter test

    SciTech Connect

    Poirier, M.; Burket, P.

    2016-03-01

    The Savannah River Site (SRS) is currently treating radioactive liquid waste with the Actinide Removal Process (ARP) and the Modular Caustic Side Solvent Extraction Unit (MCU). Recently, the low filter flux through the ARP of approximately 5 gallons per minute has limited the rate at which radioactive liquid waste can be treated. Salt Batch 6 had a lower processing rate and required frequent filter cleaning. There is a desire to understand the causes of the low filter flux and to increase ARP/MCU throughput. This task attempted to simulate the entire ARP process, including multiple batches (5), washing, chemical cleaning, and blending the feed with heels and recycle streams. The objective of the tests was to determine whether one of these processes is causing excessive fouling of the crossflow or secondary filter. The authors conducted the tests with feed solutions containing 6.6 M sodium Salt Batch 6 simulant supernate with no MST.

  9. Centrifugal contractors for laboratory-scale solvent extraction tests

    SciTech Connect

    Leonard, R.A.; Chamberlain, D.B.; Conner, C.

    1995-12-31

    A 2-cm contactor (minicontactor) was developed and used at Argonne National Laboratory for laboratory-scale testing of solvent extraction flowsheets. This new contactor requires only 1 L of simulated waste feed, which is significantly less than the 10 L required for the 4-cm unit that had previously been used. In addition, the volume requirements for the other aqueous and organic feeds are reduced correspondingly. This paper (1) discusses the design of the minicontactor, (2) describes results from having applied the minicontactor to testing various solvent extraction flowsheets, and (3) compares the minicontactor with the 4-cm contactor as a device for testing solvent extraction flowsheets on a laboratory scale.

  10. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  11. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  12. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  13. Draft Test Guideline: Site-Specific Aquatic Microcosm Test, Laboratory

    EPA Pesticide Factsheets

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  14. Draft Test Guideline: Generic Freshwater Microcosm Test, Laboratory

    EPA Pesticide Factsheets

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  15. Analysis and Test Support for Phillips Laboratory Precision Structures

    DTIC Science & Technology

    1998-11-01

    Air Force Research Laboratory ( AFRL ), Phillips Research Site . Task objectives centered...around analysis and structural dynamic test support on experiments within the Space Vehicles Directorate at Kirtland Air Force Base. These efforts help...support for Phillips Laboratory Precision Structures." Mr. James Goodding of CSA Engineering was the principal investigator for this task. Mr.

  16. Electronic Systems Test Laboratory (ESTL) User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Robinson, Neil

    2011-01-01

    Test process, milestones and inputs are unknowns to first-time users of the ESTL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  17. Structures Test Laboratory (STL). User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Zipay, John J.

    2011-01-01

    Test process, milestones and inputs are unknowns to first-time users of the STL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  18. 36. Panoramic shot from atop Power Plant, Coal Testing Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. Panoramic shot from atop Power Plant, Coal Testing Laboratory (left), Aerial Tramway Loading Terminal (center), and Huber Breaker (right) Photograph taken by Joseph E.B. Elliot - Huber Coal Breaker, 101 South Main Street, Ashley, Luzerne County, PA

  19. Inter-laboratory validation of bioaccessibility testing for metals.

    PubMed

    Henderson, Rayetta G; Verougstraete, Violaine; Anderson, Kim; Arbildua, José J; Brock, Thomas O; Brouwers, Tony; Cappellini, Danielle; Delbeke, Katrien; Herting, Gunilla; Hixon, Greg; Odnevall Wallinder, Inger; Rodriguez, Patricio H; Van Assche, Frank; Wilrich, Peter; Oller, Adriana R

    2014-10-01

    Bioelution assays are fast, simple alternatives to in vivo testing. In this study, the intra- and inter-laboratory variability in bioaccessibility data generated by bioelution tests were evaluated in synthetic fluids relevant to oral, inhalation, and dermal exposure. Using one defined protocol, five laboratories measured metal release from cobalt oxide, cobalt powder, copper concentrate, Inconel alloy, leaded brass alloy, and nickel sulfate hexahydrate. Standard deviations of repeatability (sr) and reproducibility (sR) were used to evaluate the intra- and inter-laboratory variability, respectively. Examination of the sR:sr ratios demonstrated that, while gastric and lysosomal fluids had reasonably good reproducibility, other fluids did not show as good concordance between laboratories. Relative standard deviation (RSD) analysis showed more favorable reproducibility outcomes for some data sets; overall results varied more between- than within-laboratories. RSD analysis of sr showed good within-laboratory variability for all conditions except some metals in interstitial fluid. In general, these findings indicate that absolute bioaccessibility results in some biological fluids may vary between different laboratories. However, for most applications, measures of relative bioaccessibility are needed, diminishing the requirement for high inter-laboratory reproducibility in absolute metal releases. The inter-laboratory exercise suggests that the degrees of freedom within the protocol need to be addressed.

  20. Laboratory testing trends for respiratory syncytial virus, 2007-2011.

    PubMed

    Rabon-Stith, Karma M; McGuiness, Catherine Balderston; Saunders, Brett; Edelman, Laurel; Kumar, Veena R; Boron, Marnie L

    2013-11-01

    Antigen detection tests have been the most common diagnostic assay used to detect and diagnose respiratory syncytial virus (RSV). The utility and increased sensitivity of polymerase chain reaction (PCR) tests have been reported; however, their use in US hospital laboratories is not well characterized. To describe changes in RSV test types used by US hospital-affiliated laboratories, focusing on PCR testing prevalence. Data were collected from 480 to 666 laboratories each RSV season (2007-2008 through 2010-2011) across 50 states, the District of Columbia, and Puerto Rico. A descriptive analysis was conducted using this convenience sample of RSV tests conducted from November to April each season. Total numbers and types of RSV tests performed were reported weekly and weekly proportions by test type were calculated. Kendall τ rank correlation was used to quantify associations between time and proportions of each test type. PCR tests accounted for 2%, 3%, 16%, and 21% of weekly tests (total range, 381,068-481,654 over 4 seasons) conducted each season from 2007 to 2011, respectively. The proportion of laboratories reporting ≥1 PCR tests was 4%, 5%, 10%, and 16%, respectively. Decreases in antigen testing and viral culture were similarly observed. Although antigen detection was the predominant test type reported in the sample of US hospital laboratories for RSV testing, PCR use increased to >20% of tests reported. These results demonstrate the increasing contribution of PCR to RSV surveillance. RSV surveillance systems relying solely on antigen detection results will not capture an increasing proportion of RSV test results. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Carrier screening for cystic fibrosis in US genetic testing laboratories: a survey of laboratory directors.

    PubMed

    Kaufman, D J; Katsanis, S H; Javitt, G H; Murphy, J A; Scott, J A; Hudson, K L

    2008-10-01

    Initial guidelines for cystic fibrosis (CF) carrier screening were issued in 2001 by the American College of Medical Genetics and the American College of Obstetricians and Gynecologists and updated in 2004. It is unknown how these guidelines have influenced laboratory practice. This study examined the uptake of two components of these guidelines for CF screening in genetic testing laboratories. A survey of directors of US genetic testing laboratories was conducted. Of 190 respondents, 178 answered questions about CF testing. Nearly half (49%) performed some type of DNA testing for CF; most of these (92%) performed CF carrier screening. Ten percent used a 23-mutation panel for CF screening. The results of 5T tests were reported as a reflex test by 79% of laboratories, while 8% always returned 5T results and 7% never returned them. Seven percent of laboratories adopted both guidelines, 80% adopted one of the two guidelines, and 13% had not adopted either recommendation, suggesting that factors other than clinical guidelines may influence laboratories' CF screening practices. Further studies are needed to determine whether the adoption of CF screening guidelines has significant clinical or economic effects on population-based CF screening programs.

  2. Statewide survey of laboratories performing Mycobacterium tuberculosis testing in Minnesota.

    PubMed Central

    Mills, W A; Besser-Wiek, J M; Osterholm, M T; MacDonald, K L

    1996-01-01

    Rapid and accurate laboratory detection and identification of Mycobacterium tuberculosis, particularly multidrug-resistant strains, is critical to both public health control measures and patient management. The authors surveyed microbiology laboratories to evaluate whether their methods met national guidelines. As needed, laboratories received individualized recommendations for improvement. The laboratories were resurveyed a year later to assess changes in methods. Current guidelines recommend fluorochrome acid-fast smears, broth cultures, identification by nucleic acid probe or BACTEC-NAP, and BACTEC primary susceptibility panels, which should include pyrazinamide. Of 27 laboratories performing acid-fast smears, 15 used fluorochrome methods. Six of 16 laboratories performing mycobacterial cultures used broth media. Of six laboratories performing species identification, five used nucleic acid probes or BACTEC-NAP. Of five laboratories evaluating drug sensitivity, two used BACTEC and two included pyrazinamide in their protocols. Overall, 24 (89%) laboratories needed improvements; a year later, 16 (67%) of those had altered their methods or made definite plans to do so. Survey results suggest that health departments can facilitate improvements in laboratory testing for pathogens of public health importance. PMID:8606914

  3. Immediate needs for MQA testing at state secondary calibration laboratories

    SciTech Connect

    Cline, R.

    1993-12-31

    The Calibration Laboratory attempts to provide services that satisfy the needs and requests for a variety of customers. New needs and requests have resulted in calibration of instrumentation outside the original laboratory designs. These tasks require several changes at the laboratory and a need for new support services, especially measurement quality assurance (MQA). The MQA tests are gamma (Cs-137) below 0.5 mrem (5{mu}Sv) per hour and x-ray kVp. Modification to the current gamma (Cs-137) MQA test is recommended because lower intensity fields are commonly measured.

  4. Recommended procedures for performance testing of radiobioassay laboratories: Volume 3, In vivo test phantoms

    SciTech Connect

    MacLellan, J.A.; Traub, R.J.

    1988-11-01

    Draft American National Standards Institute (ANSI) Standard N13.30 (Performance Criteria for Radiobioassay) was developed for the US Department of Energy and the US Nuclear Regulatory Commission to help ensure that bioassay laboratories provide accurate and consistent results. The draft standard describes the procedures necessary to establish a bioassay performance-testing laboratory and program. The bioassay performance-testing laboratory will conduct tests to evaluate the performance of service laboratories. Pacific Northwest Laboratory helped develop testing procedures as part of an effort to evaluate the draft ANSI N13.30 performance criteria by testing the existing measurement capabilities of various bioassay laboratories. This report recommends guidelines for the preparation, handling, storage, distribution, shipping, and documentation of test phantoms used for calibration of measurement systems for direct bioassay. The data base and recommended records system for documenting radiobioassay performance at the service laboratories are also presented.

  5. Imaging and laboratory testing in acute abdominal pain.

    PubMed

    Panebianco, Nova L; Jahnes, Katherine; Mills, Angela M

    2011-05-01

    When discussing which laboratory tests or imaging to order in the setting of acute abdominal pain, it is practical to organize information by disease process (eg, acute appendicitis, cholecystitis). Because studies on the accuracy of diagnostic tests are of necessity related to the presence or absence of specific diagnoses, and because clinicians frequently look to tests to help them rule in or rule out specific conditions, this article is organized by region of pain and common abdominal diagnoses. It focuses on the contributions that laboratory testing and imaging make in the emergency management of abdominal complaints. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Harmonization of laboratory testing - Current achievements and future strategies.

    PubMed

    Tate, Jillian R; Johnson, Roger; Barth, Julian; Panteghini, Mauro

    2014-05-15

    Harmonization in laboratory testing is more far-reaching than merely analytical harmonization. It includes all aspects of the total testing process from the "pre-pre-analytical" phase through analysis to the "post-post-analytical" phase. Harmonizing the pre-analytical phase requires use of standardized operating procedures for correct test selection, sample collection and handling, while standardized test terminology, and units and traceability to ISO standard 17511 are required to ensure equivalency of measurement results. Use of harmonized reference intervals and decision limits for analytes where platforms share allowable bias requirements will reduce inaccurate clinical interpretation and unnecessary laboratory testing. In the post-analytical phase, harmonized procedures for the management of critical laboratory test results are required to improve service quality and ensure patient safety. Monitoring of the outcomes of harmonization activities is through surveillance by external quality assessment schemes that use commutable materials and auditing of the "pre-pre-analytical" and "post-post-analytical" phases. Successful implementation of harmonization in laboratory testing requires input by all stakeholders, including the clinical laboratory community, diagnostics industry, clinicians, professional societies, IT providers, consumer advocate groups and governmental bodies.

  7. Reducing unnecessary inpatient laboratory testing in a teaching hospital.

    PubMed

    May, Todd A; Clancy, Mary; Critchfield, Jeff; Ebeling, Fern; Enriquez, Anita; Gallagher, Carmel; Genevro, Jim; Kloo, Jay; Lewis, Paul; Smith, Rita; Ng, Valerie L

    2006-08-01

    After an inpatient phlebotomy-laboratory test request audit for 2 general inpatient wards identified 5 tests commonly ordered on a recurring basis, a multidisciplinary committee developed a proposal to minimize unnecessary phlebotomies and laboratory tests by reconfiguring the electronic order function to limit phlebotomy-laboratory test requests to occur singly or to recur within one 24-hour window. The proposal was implemented in June 2003. Comparison of fiscal year volume data from before (2002-2003) and after (2003-2004) implementation revealed 72,639 (12.0%) fewer inpatient tests, of which 41,765 (57.5%) were related directly to decreases in the 5 tests frequently ordered on a recurring basis. Because the electronic order function changes did not completely eliminate unnecessary testing, we concluded that the decrease in inpatient testing represented a minimum amount of unnecessary inpatient laboratory tests. We also observed 17,207 (21.4%) fewer inpatient phlebotomies, a decrease sustained in fiscal year 20042005. Labor savings allowed us to redirect phlebotomists to our understaffed outpatient phlebotomy service.

  8. Equipment qualification testing evaluation experiences at Sandia National Laboratories

    SciTech Connect

    Bustard, L.D.; Wyant, F.J.; Bonzon, L.L.; Gillen, K.T.

    1986-01-01

    The USNRC has sponsored a number of programs at Sandia National Laboratories specifically addressing safety-related equipment qualification. The most visible of these programs has been the Qualification Testing Evaluation (QTE) program. Other relevant programs have included the Equipment Qualification Methodology Research Test program (CAP). Over a ten year period these programs have collectively tested numerous types of safety-related equipment. Some insights and conclusions extracted from these testing experiences are summarized in this report.

  9. Package testing capabilities at the Pacific Northwest Laboratory

    SciTech Connect

    Taylor, J.M.

    1993-06-01

    The purpose of this paper is to describe the package testing capabilities at the Pacific Northwest Laboratory (PNL). In the past all of the package testing that was performed at PNL was done on prototype or mocked up radioactive material packaging. Presently, we are developing the capability to perform testing on non-radioactive material packaging. The testing on the non-radioactive material packaging will be done to satisfy the new performance oriented packaging requirements (DOT Docket HM-181, 1991). This paper describes the equipment used to perform the performance oriented packaging tests and also describes some testing capability for testing radioactive material packaging.

  10. Package testing capabilities at the Pacific Northwest Laboratory

    SciTech Connect

    Taylor, J.M.

    1993-01-01

    The purpose of this paper is to describe the package testing capabilities at the Pacific Northwest Laboratory (PNL). In the past all of the package testing that was performed at PNL was done on prototype or mocked up radioactive material packaging. Presently, we are developing the capability to perform testing on non-radioactive material packaging. The testing on the non-radioactive material packaging will be done to satisfy the new performance oriented packaging requirements (DOT Docket HM-181, 1991). This paper describes the equipment used to perform the performance oriented packaging tests and also describes some testing capability for testing radioactive material packaging.

  11. Comparison of Performance Characteristics of Aspergillus PCR in Testing a Range of Blood-Based Samples in Accordance with International Methodological Recommendations.

    PubMed

    Springer, Jan; White, P Lewis; Hamilton, Shanna; Michel, Denise; Barnes, Rosemary A; Einsele, Hermann; Löffler, Juergen

    2016-03-01

    Standardized methodologies for the molecular detection of invasive aspergillosis (IA) have been established by the European Aspergillus PCR Initiative for the testing of whole blood, serum, and plasma. While some comparison of the performance of Aspergillus PCR when testing these different sample types has been performed, no single study has evaluated all three using the recommended protocols. Standardized Aspergillus PCR was performed on 423 whole-blood pellets (WBP), 583 plasma samples, and 419 serum samples obtained from hematology patients according to the recommendations. This analysis formed a bicenter retrospective anonymous case-control study, with diagnosis according to the revised European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) consensus definitions (11 probable cases and 36 controls). Values for clinical performance using individual and combined samples were calculated. For all samples, PCR positivity was significantly associated with cases of IA (for plasma, P = 0.0019; for serum, P = 0.0049; and for WBP, P = 0.0089). Plasma PCR generated the highest sensitivity (91%); the sensitivities for serum and WBP PCR were 80% and 55%, respectively. The highest specificity was achieved when testing WBP (96%), which was significantly superior to the specificities achieved when testing serum (69%, P = 0.0238) and plasma (53%, P = 0.0002). No cases were PCR negative in all specimen types, and no controls were PCR positive in all specimens. This study confirms that Aspergillus PCR testing of plasma provides robust performance while utilizing commercial automated DNA extraction processes. Combining PCR testing of different blood fractions allows IA to be both confidently diagnosed and excluded. A requirement for multiple PCR-positive plasma samples provides similar diagnostic utility and is technically less demanding. Time

  12. Comparison of Performance Characteristics of Aspergillus PCR in Testing a Range of Blood-Based Samples in Accordance with International Methodological Recommendations

    PubMed Central

    Springer, Jan; Hamilton, Shanna; Michel, Denise; Barnes, Rosemary A.; Einsele, Hermann; Löffler, Juergen

    2016-01-01

    Standardized methodologies for the molecular detection of invasive aspergillosis (IA) have been established by the European Aspergillus PCR Initiative for the testing of whole blood, serum, and plasma. While some comparison of the performance of Aspergillus PCR when testing these different sample types has been performed, no single study has evaluated all three using the recommended protocols. Standardized Aspergillus PCR was performed on 423 whole-blood pellets (WBP), 583 plasma samples, and 419 serum samples obtained from hematology patients according to the recommendations. This analysis formed a bicenter retrospective anonymous case-control study, with diagnosis according to the revised European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) consensus definitions (11 probable cases and 36 controls). Values for clinical performance using individual and combined samples were calculated. For all samples, PCR positivity was significantly associated with cases of IA (for plasma, P = 0.0019; for serum, P = 0.0049; and for WBP, P = 0.0089). Plasma PCR generated the highest sensitivity (91%); the sensitivities for serum and WBP PCR were 80% and 55%, respectively. The highest specificity was achieved when testing WBP (96%), which was significantly superior to the specificities achieved when testing serum (69%, P = 0.0238) and plasma (53%, P = 0.0002). No cases were PCR negative in all specimen types, and no controls were PCR positive in all specimens. This study confirms that Aspergillus PCR testing of plasma provides robust performance while utilizing commercial automated DNA extraction processes. Combining PCR testing of different blood fractions allows IA to be both confidently diagnosed and excluded. A requirement for multiple PCR-positive plasma samples provides similar diagnostic utility and is technically less demanding. Time

  13. Constrained Laboratory vs. Unconstrained Steering-Induced Rollover Crash Tests.

    PubMed

    Kerrigan, Jason R; Toczyski, Jacek; Roberts, Carolyn; Zhang, Qi; Clauser, Mark

    2015-01-01

    The goal of this study was to evaluate how well an in-laboratory rollover crash test methodology that constrains vehicle motion can reproduce the dynamics of unconstrained full-scale steering-induced rollover crash tests in sand. Data from previously-published unconstrained steering-induced rollover crash tests using a full-size pickup and mid-sized sedan were analyzed to determine vehicle-to-ground impact conditions and kinematic response of the vehicles throughout the tests. Then, a pair of replicate vehicles were prepared to match the inertial properties of the steering-induced test vehicles and configured to record dynamic roof structure deformations and kinematic response. Both vehicles experienced greater increases in roll-axis angular velocities in the unconstrained tests than in the constrained tests; however, the increases that occurred during the trailing side roof interaction were nearly identical between tests for both vehicles. Both vehicles experienced linear accelerations in the constrained tests that were similar to those in the unconstrained tests, but the pickup, in particular, had accelerations that were matched in magnitude, timing, and duration very closely between the two test types. Deformations in the truck test were higher in the constrained than the unconstrained, and deformations in the sedan were greater in the unconstrained than the constrained as a result of constraints of the test fixture, and differences in impact velocity for the trailing side. The results of the current study suggest that in-laboratory rollover tests can be used to simulate the injury-causing portions of unconstrained rollover crashes. To date, such a demonstration has not yet been published in the open literature. This study did, however, show that road surface can affect vehicle response in a way that may not be able to be mimicked in the laboratory. Lastly, this study showed that configuring the in-laboratory tests to match the leading-side touchdown conditions

  14. Field test of the Rapid Transuranic Monitoring Laboratory

    SciTech Connect

    McIsaac, C.V.; Sill, C.W.; Gehrke, R.J.; Killian, E.W.; Watts, K.D.; Amaro, C.R.

    1993-12-01

    A field test of the Rapid Transuranic Monitoring Laboratory (RTML) developed at the Idaho National Engineering Laboratory (INEL) was conducted as part of a demonstration sponsored by the Buried Waste Integrated Demonstration (BWID). The RTML is a mobile, field- deployable laboratory developed for use at buried radioactive waste remediation sites to allow onsite preparation and analysis of soil, smear, and air filter samples for alpha and gamma-emitting contaminants. Analytical instruments installed in the RTML include an extended range, germanium photon analysis spectrometer with an automatic sample changer, two large-area ionization chamber alpha spectrometers, and four alpha continuous air monitors. The performance of the RTML was tested at the Test Reactor Area and Cold Test Pit near the Radioactive Waste Management Complex at the INEL. Objectives, experimental procedures, and an evaluation of the performance of the RTML are presented.

  15. Do Laboratory Tests Predict Everyday Memory? A Neuropsychological Study.

    ERIC Educational Resources Information Center

    Sunderland, Alan; And Others

    1983-01-01

    The relationship between memory performance in everyday life and performance on laboratory tests was investigated with normal-memory and previously severely head-injured subjects. Correlation of the two test types was found in normal-memory and long-term head-injured, but not with the recently-injured. Highest correlations were with prose recall…

  16. An Education Program to Reduce Unnecessary Laboratory Tests by Residents.

    ERIC Educational Resources Information Center

    Dowling, Patrick T.; And Others

    1989-01-01

    A program at an inner-city community health center involving 20 family practice residents provided an educational intervention concerning the use of laboratory tests based on quality of care, not cost containment. During the program, the use of thyroid stimulating hormone test declined, while complete blood counts ordered did not. (MSE)

  17. Flight Testing the Landing Radar for Mars Science Laboratory

    NASA Image and Video Library

    2011-06-21

    A NASA Dryden Flight Research Center F/A-18 852 aircraft performs a roll during June 2011 flight tests of a Mars landing radar. A test model of the landing radar for NASA Mars Science Laboratory mission is inside a pod under the aircraft left wing.

  18. An Education Program to Reduce Unnecessary Laboratory Tests by Residents.

    ERIC Educational Resources Information Center

    Dowling, Patrick T.; And Others

    1989-01-01

    A program at an inner-city community health center involving 20 family practice residents provided an educational intervention concerning the use of laboratory tests based on quality of care, not cost containment. During the program, the use of thyroid stimulating hormone test declined, while complete blood counts ordered did not. (MSE)

  19. Physician satisfaction and emergency department laboratory test turnaround time.

    PubMed

    Steindel, S J; Howanitz, P J

    2001-07-01

    To determine the length of time for the components of the emergency department (ED) turnaround time (TAT) study in 1998 and to ascertain physician satisfaction concerning laboratory services to the ED. Using forms supplied by the College of American Pathologists Q-Probes program, participants conducted a self-directed study of ED TAT over a 4-week period. Data requested included various times of day associated with the ordering, specimen collection, laboratory receipt, and result-reporting stages of stat ED TATs for potassium and hemoglobin. Additionally, practice-related questions associated with the laboratory were asked. Participating laboratories also provided a physician satisfaction survey for up to 4 physicians who were users of ED services. Results of both the TAT study and the physician satisfaction survey were returned by mail. Participants were drawn from the 952 hospital laboratories enrolled in the 1998 College of American Pathologists Q-Probes study on ED TAT. The main outcome measures included the components of the ED TAT process, factors associated with decreases in ED TAT, and the results of the physician satisfaction survey. Six hundred ninety hospital laboratories (72.4% response rate) returned data on up to 18 230 hemoglobin and 18 259 potassium specimens. Half of these laboratories responded that 90% of potassium tests were ordered and reported in 69 minutes or less, whereas the TAT for 90% of hemoglobin results was 55 minutes or less. Comparison of the components of TAT for both potassium and hemoglobin with similar studies done in 1990 and 1993 showed no change. Factors found to statistically contribute to faster TATs for both tests were laboratory control of specimen handling and rapid transport time. When whole blood specimens were used for potassium determination, TAT improved. Emergency department physicians chose the study-defined lower satisfaction categories of Often, Sometimes, Rarely, and Never for the questions concerning the

  20. Deep Borehole Field Test Laboratory and Borehole Testing Strategy

    SciTech Connect

    Kuhlman, Kristopher L.; Brady, Patrick V.; MacKinnon, Robert J.; Heath, Jason E.; Herrick, Courtney G.; Jensen, Richard P.; Gardner, W. Payton; Sevougian, S. David; Bryan, Charles R.; Jang, Je-Hun; Stein, Emily R.; Bauer, Stephen J.; Daley, Tom; Freifeld, Barry M.; Birkholzer, Jens; Spane, Frank A.

    2016-09-19

    Deep Borehole Disposal (DBD) of high-level radioactive wastes has been considered an option for geological isolation for many years (Hess et al. 1957). Recent advances in drilling technology have decreased costs and increased reliability for large-diameter (i.e., ≥50 cm [19.7”]) boreholes to depths of several kilometers (Beswick 2008; Beswick et al. 2014). These advances have therefore also increased the feasibility of the DBD concept (Brady et al. 2009; Cornwall 2015), and the current field test design will demonstrate the DBD concept and these advances. The US Department of Energy (DOE) Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (DOE 2013) specifically recommended developing a research and development plan for DBD. DOE sought input or expression of interest from States, local communities, individuals, private groups, academia, or any other stakeholders willing to host a Deep Borehole Field Test (DBFT). The DBFT includes drilling two boreholes nominally 200m [656’] apart to approximately 5 km [16,400’] total depth, in a region where crystalline basement is expected to begin at less than 2 km depth [6,560’]. The characterization borehole (CB) is the smaller-diameter borehole (i.e., 21.6 cm [8.5”] diameter at total depth), and will be drilled first. The geologic, hydrogeologic, geochemical, geomechanical and thermal testing will take place in the CB. The field test borehole (FTB) is the larger-diameter borehole (i.e., 43.2 cm [17”] diameter at total depth). Surface handling and borehole emplacement of test package will be demonstrated using the FTB to evaluate engineering feasibility and safety of disposal operations (SNL 2016).

  1. 42 CFR 493.1415 - Condition: Laboratories performing moderate complexity testing; clinical consultant.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... complexity testing; clinical consultant. 493.1415 Section 493.1415 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1415 Condition: Laboratories performing moderate complexity testing; clinical consultant....

  2. 42 CFR 493.1409 - Condition: Laboratories performing moderate complexity testing; technical consultant.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... complexity testing; technical consultant. 493.1409 Section 493.1409 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1409 Condition: Laboratories performing moderate complexity testing; technical consultant....

  3. 42 CFR 493.1409 - Condition: Laboratories performing moderate complexity testing; technical consultant.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... complexity testing; technical consultant. 493.1409 Section 493.1409 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1409 Condition: Laboratories performing moderate complexity testing; technical consultant....

  4. 42 CFR 493.1415 - Condition: Laboratories performing moderate complexity testing; clinical consultant.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... complexity testing; clinical consultant. 493.1415 Section 493.1415 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1415 Condition: Laboratories performing moderate complexity testing; clinical consultant....

  5. Laboratory Diagnostics Market in East Africa: A Survey of Test Types, Test Availability, and Test Prices in Kampala, Uganda.

    PubMed

    Schroeder, Lee F; Elbireer, Ali; Jackson, J Brooks; Amukele, Timothy K

    2015-01-01

    Diagnostic laboratory tests are routinely defined in terms of their sensitivity, specificity, and ease of use. But the actual clinical impact of a diagnostic test also depends on its availability and price. This is especially true in resource-limited settings such as sub-Saharan Africa. We present a first-of-its-kind report of diagnostic test types, availability, and prices in Kampala, Uganda. Test types (identity) and availability were based on menus and volumes obtained from clinical laboratories in late 2011 in Kampala using a standard questionnaire. As a measure of test availability, we used the Availability Index (AI). AI is the combined daily testing volumes of laboratories offering a given test, divided by the combined daily testing volumes of all laboratories in Kampala. Test prices were based on a sampling of prices collected in person and via telephone surveys in 2015. Test volumes and menus were obtained for 95% (907/954) of laboratories in Kampala city. These 907 laboratories offered 100 different test types. The ten most commonly offered tests in decreasing order were Malaria, HCG, HIV serology, Syphilis, Typhoid, Urinalysis, Brucellosis, Stool Analysis, Glucose, and ABO/Rh. In terms of AI, the 100 tests clustered into three groups: high (12 tests), moderate (33 tests), and minimal (55 tests) availability. 50% and 36% of overall availability was provided through private and public laboratories, respectively. Point-of-care laboratories contributed 35% to the AI of high availability tests, but only 6% to the AI of the other tests. The mean price of the most commonly offered test types was $2.62 (range $1.83-$3.46). One hundred different laboratory test types were in use in Kampala in late 2011. Both public and private laboratories were critical to test availability. The tests offered in point-of-care laboratories tended to be the most available tests. Prices of the most common tests ranged from $1.83-$3.46.

  6. Use of computers in quality assurance of laboratory testing.

    PubMed

    Tan, I K; Jacob, E; Lim, S H

    1990-09-01

    Implementation of comprehensive internal quality control programmes and participation in external quality assessment schemes to monitor analytical performance of laboratory tests have been widely accepted as an essential and integral part of good laboratory practice. As these programmes involve a great deal of repetitive statistical calculations and graphic presentation of data on quality control materials, many laboratories and practically all organisers of inter-laboratory quality assessment schemes increasingly rely on computers to handle the burdensome processing of data and to provide timely feedback in a manner that is easily understood and readily interpreted by analytical staff. However, in spite of the best effort to ensure reliable analytical performance, spurious and misleading results can still occur as a result of non-analytical errors which are not readily detected by methods designed to monitor the quality of analytical process. The use of sophisticated computer system has enabled our laboratory to check for the existence of some of these errors. This paper describes the application of computers in a variety of internal and external quality assessment programmes and demonstrates the usefulness of retrieving patients' cumulative test results and at the same time performing delta or percentage difference checks on such data in the detection of non-analytical errors and unexpected variations in results. The role of the computer in minimising transcription errors, reducing turn-around time of testing and reporting, as well as improving the quality of laboratory reports is also mentioned.

  7. Interventions at the laboratory level to reduce laboratory test ordering by family physicians: Systematic review.

    PubMed

    Thomas, Roger E; Vaska, Marcus; Naugler, Christopher; Turin, Tanvir C

    2015-12-01

    To assess the effectiveness of interventions by laboratories and to increase rational and reduce unnecessary family physician test ordering. MEDLINE [1946-present], EMBASE [1980-present], EBM Reviews [1991-present](Cochrane Database of Systematic Reviews, ACP Journal Club, Database of Abstracts of Reviews of Effects, - Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Health Technology Assessment, NHS Economic Evaluation Database), PubMed [1966-present], PubMed Central [1900-present], Scopus [1960-present], Web of Science [1900-present] and CINAHL [1982-present] were searched with no language or publication limits. Non-randomised studies were assessed with the Newcastle-Ottawa scale. The search identified 9282 titles and abstracts, 238 were read in full-text and 3 cohort and 7 before- and after-studies were included. Most focused on changing a few tests and evaluated the interventions over several months. Seven changed laboratory forms (the two largest involved 5.2 million and 3.2 million tests), one negotiated a test ordering protocol with family physicians, and two required laboratory approval. They achieved an average 35% reduction in the 19 targeted tests, with a wide range (0%-100% reduction). Ten studies were identified which tested interventions by laboratories to reduce test ordering by family physicians, and achieved an average 35% reduction in the 19 targeted tests. The rationale for choosing specific tests for intervention was often not explained, most studies targeted a few tests for several months, the tests and test volumes differed widely across studies, no author improved the results of previous interventions or asked participants their opinions about the intervention or assessed factors impeding change. Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  8. Evaluation of a laboratory test model annular momentum control device

    NASA Technical Reports Server (NTRS)

    Groom, N. J.; Terray, D. E.

    1978-01-01

    A 4068 Nm Sec laboratory test model annular momentum control device (AMCD) was described and static and dynamic test results were presented. An AMCD is a spinning annular rim suspended by noncontacting magnetic bearings and powered by a noncontacting linear electromagnetic motor. Test results include spin motor torque characteristics and spin motor and magnetic bearing drag losses. Limitations of some of the design approaches taken was also discussed.

  9. The age of competence: an update on the international laboratory accreditation scene for veterinary testing laboratories.

    PubMed

    Wiegers, Ann L

    2002-03-01

    Many changes have recently taken place in the world of laboratory accreditation. These changes include the increased use of voluntary standards in lieu of regulations, a move towards harmonization (equivalent results using voluntary standards) over standardization (using the same procedures or regulations), and an increased focus on competence, which includes the competence of laboratories to conduct testing, the competence of accreditation bodies to operate accreditation programs, the competence of bodies such as the National Cooperation for Laboratory Accreditation (NACLA) to recognize accreditation bodies as meeting the requirements of relevant standards, and the competence of organizations providing services to the accreditation process, such as the operation of proficiency testing programs. To describe these changes, a brief and general description of the International Laboratory Accreditation Cooperation accreditation scheme is provided, including an update on relevant decisions and activities in the United States and a description of the organization and activities of the newly formed NACLA. Following this discussion, with emphasis on veterinary testing, is an overview of several national and international organizations, including accreditation bodies, that promote harmonization, standardization, and analytical excellence. Also outlined are relevant activities of these organizations, an overview of some of the standards and guidelines they produce, and a description of how such organizations interact with each other and with laboratories seeking recognition for competence. Next is a brief discussion of recent developments and trends in laboratory accreditation, the impact of these developments, and the costs and benefits of accreditation to laboratories. Suggestions to veterinary laboratories for formulating strategy for keeping current with developments in accreditation and for determining quality goals are included.

  10. Five Proficiency Testing Programs for the Jcss Weight Calibration Laboratories

    NASA Astrophysics Data System (ADS)

    Ueki, Masaaki; Sun, Jianxin; Ueda, Kazunaga

    The Japan Calibration Service System (JCSS) organized in 1993 accredits the measurement capability of calibration laboratories and ensures the traceability to the national measurement standards. As an essential part of accreditation of the measurement capability of calibration laboratories for the weights, the International Accreditation Japan (IAJapan) of National Institute of Technology and Evaluation has been operating the JCSS proficiency testing programs with the technical support of the National Metrology Institute of Japan (NMIJ/AIST). Up to now, five proficiency testing programs have been carried out for the JCSS weight calibration laboratories in the range of 2 mg to 10 kg. The proficiency testing programs organized by the IAJapan were carried out in accordance with ISO/IEC Guide 43 (JIS Q 17043), and the NMIJ was responsible for the technical aspect as a reference laboratory. This paper describes the methods of the five proficiency testing programs during the period from 1997 to 2009, and outlines assessment of the measurement capability of the JCSS weight calibration laboratories.

  11. Reproduction of natural corrosion by accelerated laboratory testing methods

    SciTech Connect

    Luo, J.S.; Wronkiewicz, D.J.; Mazer, J.J.; Bates, J.K.

    1996-05-01

    Various laboratory corrosion tests have been developed to study the behavior of glass waste forms under conditions similar to those expected in an engineered repository. The data generated by laboratory experiments are useful for understanding corrosion mechanisms and for developing chemical models to predict the long-term behavior of glass. However, it is challenging to demonstrate that these test methods produce results that can be directly related to projecting the behavior of glass waste forms over time periods of thousands of years. One method to build confidence in the applicability of the test methods is to study the natural processes that have been taking place over very long periods in environments similar to those of the repository. In this paper, we discuss whether accelerated testing methods alter the fundamental mechanisms of glass corrosion by comparing the alteration patterns that occur in naturally altered glasses with those that occur in accelerated laboratory environments. This comparison is done by (1) describing the alteration of glasses reacted in nature over long periods of time and in accelerated laboratory environments and (2) establishing the reaction kinetics of naturally altered glass and laboratory reacted glass waste forms.

  12. The role of laboratory in ensuring appropriate test requests.

    PubMed

    Ferraro, Simona; Panteghini, Mauro

    2017-07-01

    This review highlights the role of laboratory professionals and the strategies to be promoted in strict cooperation with clinicians for auditing, monitoring and improving the appropriateness of test request. The introduction of local pathways and care maps in agreement with international and national guidelines as well as the implementation of reflex testing and algorithms have a central role in guiding test request and in correcting the overuse/misuse of tests. Furthermore, removing obsolete tests from laboratory menu and vetting of restricted tests is recommended to increase cost-effectiveness. This saves costs and permits to introduce new biomarkers with increased diagnostic accuracy with a better impact on patient outcome. An additional issue is concerning the periodicity of (re)testing, accounting that only a minority of tests may be ordered as often as necessary. In the majority of cases, a minimum retesting interval should be introduced. The availability of effective computerised order entry systems is relevant in ensuring appropriate test requests and in providing an aid by automated rules that may stop inappropriate requests before they reach the laboratory. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  13. Unnecessary repeated total cholesterol tests in biochemistry laboratory.

    PubMed

    Demir, Suleyman; Zorbozan, Nergiz; Basak, Elif

    2016-01-01

    We aimed to determine the number of repeated cholesterol (RC) tests and the ratio of unnecessary-repeated cholesterol (URC) tests among patients admitted to Pamukkale University Hospital (Denizli, Turkey) and provide solutions to avoid URC testing. Total cholesterol (T-cholesterol) tests (N = 86,817) between June 2014 and May 2015 were evaluated. The tests performed more than once per patient were determined as RC test (N = 28,811). RC test with an interval shorter than 4 weeks were determined as URC test (N = 3968) according to the shortest retest interval stated in ACC/AHA blood cholesterol guideline. RC testing included internal medicine, surgery and paediatric outpatients and inpatients. Reference change value (RCV) of total cholesterol was calculated. The 33.1% of the T-cholesterol tests were RC tests (N = 28,811), 13.7% of them were URC tests (N = 3968). Our RCV value was 25%. The percentage change between consecutive tests was less than RCV in 86.1% (N = 3418) of URC tests. URC tests were performed more frequently in patients with desirable total cholesterol value (P < 0.001). There is a significant part of repeated T-cholesterol tests requested in our hospital. URC test requests can be evaluated by laboratories and the obtained data should be shared with clinicians. Laboratories can calculate RCV for the tests they performed and report this value with the test result. To prevent from URC tests, a warning plug-in can be added to hospital information software in accordance with guidelines to prevent from URC test requests.

  14. Unnecessary repeated total cholesterol tests in biochemistry laboratory

    PubMed Central

    Demir, Suleyman; Zorbozan, Nergiz; Basak, Elif

    2016-01-01

    Introduction We aimed to determine the number of repeated cholesterol (RC) tests and the ratio of unnecessary-repeated cholesterol (URC) tests among patients admitted to Pamukkale University Hospital (Denizli, Turkey) and provide solutions to avoid URC testing. Materials and methods Total cholesterol (T-cholesterol) tests (N = 86,817) between June 2014 and May 2015 were evaluated. The tests performed more than once per patient were determined as RC test (N = 28,811). RC test with an interval shorter than 4 weeks were determined as URC test (N = 3968) according to the shortest retest interval stated in ACC/AHA blood cholesterol guideline. RC testing included internal medicine, surgery and paediatric outpatients and inpatients. Reference change value (RCV) of total cholesterol was calculated. Results The 33.1% of the T-cholesterol tests were RC tests (N = 28,811), 13.7% of them were URC tests (N = 3968). Our RCV value was 25%. The percentage change between consecutive tests was less than RCV in 86.1% (N = 3418) of URC tests. URC tests were performed more frequently in patients with desirable total cholesterol value (P < 0.001). Conclusion There is a significant part of repeated T-cholesterol tests requested in our hospital. URC test requests can be evaluated by laboratories and the obtained data should be shared with clinicians. Laboratories can calculate RCV for the tests they performed and report this value with the test result. To prevent from URC tests, a warning plug-in can be added to hospital information software in accordance with guidelines to prevent from URC test requests. PMID:26981021

  15. Rates of inappropriate laboratory test utilization in Ontario.

    PubMed

    Chami, Nadine; Simons, Janet E; Sweetman, Arthur; Don-Wauchope, Andrew C

    2017-10-01

    Medical laboratory tests ordered redundantly represent one of the targets for reducing diagnostic testing without negatively, and possibly positively, affecting patient care. We study a clearly defined category of excessive laboratory utilization for nine analytes where inappropriate diagnostic testing is defined in terms of the time interval between tests; that is, ordering a test too soon following the previous order of the same test. Population data from the near universal public Ontario Health Insurance Plan for the years 2006-2010 are employed where the tests are fulfilled by community medical laboratories. The analytes selected for consideration are thyroid stimulating hormone, hemoglobin A1c, lipid profile, serum protein electrophoresis, immunofixation, quantitative immunoglobulins, Vitamin D, Vitamin B12, and folate. For the nine analytes studied, the percentage of inappropriate tests ranged from 6% to 20%. Large proportions of these inappropriate tests were completed >2weeks prior to the minimum threshold to reorder defined by practice guidelines and/or were repeated excessively within a year. Between 60% and 85% of the time, the ordering physician of an inappropriate test was the same physician who ordered the previous test. Specialists were more likely than primary care physicians to order repeat tests too soon. A sizeable proportion of testing for these analytes was inappropriate according to practice guidelines. It is recommended that systems for preventing unnecessary repeat testing are investigated by the funding agencies and that reducing inappropriate testing be considered as a design element for electronic medical records and related information technology systems. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  16. Laboratory testing of the Sonnenschein charger, Part number DTL 12040

    SciTech Connect

    Hardin, J.E.; Martin, M.E.

    1990-09-01

    This report describes the results of testing the Sonnenschein DTL 12040 battery charger in the Idaho National Engineering Laboratory (INEL) battery laboratory. The purpose of this testing was to evaluate the suitability of this charger for charging electric vehicle battery packs made up of Sonnenschein sealed lead acid batteries or possibly other similar batteries. This evaluation consists primarily of identifying the charge algorithm used and evaluating the resulting charge behavior. Other characteristics of the charger that could be significant are also noted. 5 figs., 2 tabs.

  17. Energy-efficiency testing activities of the Mobile Energy Laboratory

    SciTech Connect

    Parker, G.B.

    1991-01-01

    This report summarizes energy-efficiency testing activities during the first and second quarters of fiscal year 1990 applying the Mobile Energy Laboratory (MEL) testing capabilities. Four MELs, developed by the US Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) for energy testing and program support functions at federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in the MEL Use Plan (PNL-6861) for semiannual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semiannually to establish priorities for energy-efficient testing applications using the MEL capabilities.

  18. Duplicated laboratory tests: evaluation of a computerized alert intervention abstract.

    PubMed

    Bridges, Sharon A; Papa, Linda; Norris, Anne E; Chase, Susan K

    2014-01-01

    Redundant testing contributes to reductions in healthcare system efficiency. The purpose of this study was to: (1) determine if the use of a computerized alert would reduce the number and cost of duplicated Acute Hepatitis Profile (AHP) laboratory tests and (2) assess what patient, test, and system factors were associated with duplication. This study used a quasi-experimental pre- and post-test design to determine the proportion of duplication of the AHP test before and after implementation of a computerized alert intervention. The AHP test was duplicated if the test was requested again within 15 days of the initial test being performed and the result present in the medical record. The intervention consisted of a computerized alert (pop-up window) that indicated to the clinician that the test had recently been ordered. A total of 674 AHP tests were performed in the pre-intervention period and 692 in the postintervention group. In the pre-intervention period, 53 (7.9%) were duplicated and in postintervention, 18 (2.6%) were duplicated (p<.001). The implementation of the alert was shown to significantly reduce associated costs of duplicated AHP tests (p≤.001). Implementation of computerized alerts may be useful in reducing duplicate laboratory tests and improving healthcare system efficiency. © 2012 National Association for Healthcare Quality.

  19. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions. 410.32 Section 410.32 Public Health CENTERS FOR MEDICARE... (SMI) BENEFITS Medical and Other Health Services § 410.32 Diagnostic x-ray tests, diagnostic laboratory...

  20. Infection control in the pulmonary function test laboratory

    PubMed Central

    Rasam, Shweta Amol; Apte, Komalkirti Keshavkiran; Salvi, Sundeep Santosh

    2015-01-01

    Pulmonary function testing plays a crucial role in the diagnostic evaluation of patients with lung diseases. Cases of cross infection acquired from the pulmonary function laboratory, although rare, have been reported from various countries. It is therefore imperative to identify the risks and potential organisms implicated in cross infections in a pulmonary function test (PFT) laboratory and implement better and more effective infection control procedures, which will help in preventing cross infections. The infrastructure, the daily patient flow, and the prevalent disinfection techniques used in a PFT laboratory, all play a significant role in transmission of infections. Simple measures to tackle the cross infection potential in a PFT laboratory can help reduce this risk to a bare minimum. Use of specialized techniques and equipment can also be of much use in a set up that has a high turnover of patients. This review aims at creating awareness about the possible pathogens and situations commonly encountered in a PFT laboratory. We have attempted to suggest some relevant and useful infection control measures with regard to disinfection, sterilization, and patient planning and segregation to help minimize the risk of cross infections in a PFT laboratory. The review also highlights the lacuna in the current scenario of PFT laboratories in India and the need to develop newer and better methods of infection control, which will be more user-friendly and cost effective. Further studies to study the possible pathogens in a PFT laboratory and evaluate the prevalent infection control strategies will be needed to enable us to draw more precious conclusions, which can lead to more relevant, contextual recommendations for cross infections control in PFT lab in India. PMID:26180386

  1. Hereditary red cell membrane disorders and laboratory diagnostic testing.

    PubMed

    King, M-J; Zanella, A

    2013-06-01

    This overview describes two groups of nonimmune hereditary hemolytic anemias caused by defects in membrane proteins located in distinct layers of the red cell membrane. Hereditary spherocytosis (HS), hereditary elliptocytosis (HE), and hereditary pyropoikilocytosis (HPP) represent disorders of the red cell cytoskeleton. Hereditary stomatocytoses represents disorders of cation permeability in the red cell membrane. The current laboratory screening tests for HS are the osmotic fragility test, acid glycerol lysis time test (AGLT), cryohemolysis test, and eosin-5'-maleimide (EMA)-binding test. For atypical HS, SDS-polyacrylamide gel electrophoresis of erythrocyte membrane proteins is carried out to confirm the diagnosis. The diagnosis of HE/HPP is based on abnormal red cell morphology and the detection of protein 4.1R deficiency or spectrin variants using gel electrophoresis. None of screening tests can detect all HS cases. Some testing centers (a survey of 25 laboratories) use a combination of tests (e.g., AGLT and EMA). No specific screening test for hereditary stomatocytoses is available. The preliminary diagnosis is based on presenting a compensated hemolytic anemia, macrocytosis, and a temperature or time dependent pseudohyperkalemia in some patients. Both the EMA-binding test and the osmotic fragility test may help in differential diagnosis of HS and hereditary stomatocytosis.

  2. French laboratory proficiency testing program for food microbiology.

    PubMed

    Augustin, Jean-Christophe; Carlier, Vincent

    2002-01-01

    The proficiency testing program in food microbiology (Réseau d'Analyses et d'Echanges en Microbiologie des Aliments; RAEMA), created in 1988, currently includes 440 participating laboratories. The program establishes proficiency in detection of Salmonella and Listeria monocytogenes, as well as quantitation of aerobic microorganisms, Enterobacteriaceae, coliforms, Escherichia coli, Clostridium perfringens, coagulase-positive Staphylococcus, and Listeria monocytogenes. Twice a year, 5 test samples are sent to participants to assess their precision and trueness for enumeration and detection of microorganisms. Results show an increasing involvement of food microbiology laboratories in quality assurance programs and use of standard and validated analytical methods. However, the percentage of laboratories obtaining questionable and unsatisfactory microbiological results remains relatively constant.

  3. Compendium of Test Results of Recent Single Event Effect Tests Conducted by the Jet Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    McClure, Steven S.; Allen, Gregory R.; Irom, Farokh; Scheick, Leif Z.; Adell, Philippe C.; Miyahira, Tetsuo F.

    2010-01-01

    This paper reports heavy ion and proton-induced single event effect (SEE) results from recent tests for a variety of microelectronic devices. The compendium covers devices tested over the last two years by the Jet Propulsion Laboratory.

  4. Test plan for demonstration of Rapid Transuranic Monitoring Laboratory

    SciTech Connect

    McIsaac, C.V.; Sill, C.W.; Gehrke, R.J.; Killian, E.W.; Watts, K.D.

    1993-06-01

    This plan describes tests to demonstrate the capability of the Rapid Transuranic Monitoring Laboratory (RTML) to monitor airborne alpha-emitting radionuclides and analyze soil, smear, and filter samples for alpha- and gamma-emitting radionuclides under field conditions. The RTML will be tested during June 1993 at a site adjacent to the Cold Test Pit at the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. Measurement systems installed in the RTML that will be demonstrated include two large-area ionization chamber alpha spectrometers, an x-ray/gamma-ray spectrometer, and four alpha continuous air monitors. Test objectives, requirements for data quality, experimental apparatus and procedures, and safety and logistics issues are described.

  5. Safety in the Chemical Laboratory: Tested Disposal Methods for Chemical Wastes from Academic Laboratories.

    ERIC Educational Resources Information Center

    Armour, M. A.; And Others

    1985-01-01

    Describes procedures for disposing of dichromate cleaning solution, picric acid, organic azides, oxalic acid, chemical spills, and hydroperoxides in ethers and alkenes. These methods have been tested under laboratory conditions and are specific for individual chemicals rather than for groups of chemicals. (JN)

  6. Safety in the Chemical Laboratory: Tested Disposal Methods for Chemical Wastes from Academic Laboratories.

    ERIC Educational Resources Information Center

    Armour, M. A.; And Others

    1985-01-01

    Describes procedures for disposing of dichromate cleaning solution, picric acid, organic azides, oxalic acid, chemical spills, and hydroperoxides in ethers and alkenes. These methods have been tested under laboratory conditions and are specific for individual chemicals rather than for groups of chemicals. (JN)

  7. GATE AND VACUUM FLUSHING OF SEWER SEDIMENT: LABORATORY TESTING

    EPA Science Inventory

    The objective of this study was to test the performance of a traditional gate-flushing device and a newly-designed vacuum-flushing device in removing sediment from combined sewers and CSO storage tanks. A laboratory hydraulic flume was used to simulate a reach of sewer or storag...

  8. GATE AND VACUUM FLUSHING OF SEWER SEDIMENT: LABORATORY TESTING

    EPA Science Inventory

    The objective of this study was to test the performance of a traditional gate-flushing device and a newly-designed vacuum-flushing device in removing sediment from combined sewers and CSO storage tanks. A laboratory hydraulic flume was used to simulate a reach of sewer or storag...

  9. Testing a Constrained MPC Controller in a Process Control Laboratory

    ERIC Educational Resources Information Center

    Ricardez-Sandoval, Luis A.; Blankespoor, Wesley; Budman, Hector M.

    2010-01-01

    This paper describes an experiment performed by the fourth year chemical engineering students in the process control laboratory at the University of Waterloo. The objective of this experiment is to test the capabilities of a constrained Model Predictive Controller (MPC) to control the operation of a Double Pipe Heat Exchanger (DPHE) in real time.…

  10. Results of Laboratory Testing of Advanced Power Strips

    SciTech Connect

    Earle, L.; Sparn, B.

    2012-08-01

    Presented at the ACEEE Summer Study on Energy Efficiency in Buildings on August 12-17, 2012, this presentation reports on laboratory tests of 20 currently available advanced power strip products, which reduce wasteful electricity use of miscellaneous electric loads in buildings.

  11. Testing a Constrained MPC Controller in a Process Control Laboratory

    ERIC Educational Resources Information Center

    Ricardez-Sandoval, Luis A.; Blankespoor, Wesley; Budman, Hector M.

    2010-01-01

    This paper describes an experiment performed by the fourth year chemical engineering students in the process control laboratory at the University of Waterloo. The objective of this experiment is to test the capabilities of a constrained Model Predictive Controller (MPC) to control the operation of a Double Pipe Heat Exchanger (DPHE) in real time.…

  12. Verification and validation of diagnostic laboratory tests in clinical virology.

    PubMed

    Rabenau, Holger F; Kessler, Harald H; Kortenbusch, Marhild; Steinhorst, Andreas; Raggam, Reinhard B; Berger, Annemarie

    2007-10-01

    This review summarizes major issues of verification and validation procedures and describes minimum requirements for verification and validation of diagnostic assays in clinical virology including instructions for CE/IVD-labeled as well as for self-developed ("home-brewed") tests or test systems. It covers techniques useful for detection of virus specific antibodies, for detection of viral antigens, for detection of viral nucleic acids, and for isolation of viruses on cell cultures in the routine virology laboratory.

  13. Performance testing of radiobioassay laboratories: In vivo measurements, Final Report

    SciTech Connect

    MacLellan, J.A.; Traub, R.J.; Olsen, P.C.

    1990-04-01

    A study of two rounds of in vivo laboratory performance testing was undertaken by Pacific Northwest Laboratory (PNL) to determine the appropriateness of the in vivo performance criteria of draft American National Standards Institute (ANSI) standard ANSI N13.3, Performance Criteria for Bioassay.'' The draft standard provides guidance to in vivo counting facilities regarding the sensitivity, precision, and accuracy of measurements for certain categories of commonly assayed radionuclides and critical regions of the body. This report concludes the testing program by presenting the results of the Round Two testing. Testing involved two types of measurements: chest counting for radionuclide detection in the lung, and whole body counting for detection of uniformly distributed material. Each type of measurement was further divided into radionuclide categories as defined in the draft standard. The appropriateness of the draft standard criteria by measuring a laboratory's ability to attain them were judged by the results of both round One and Round Two testing. The testing determined that performance criteria are set at attainable levels, and the majority of in vivo monitoring facilities passed the criteria when complete results were submitted. 18 refs., 18 figs., 15 tabs.

  14. Quality performance of laboratory testing in pharmacies: a collaborative evaluation.

    PubMed

    Zaninotto, Martina; Miolo, Giorgia; Guiotto, Adriano; Marton, Silvia; Plebani, Mario

    2016-11-01

    The quality performance and the comparability between results of pharmacies point-of-care-testing (POCT) and institutional laboratories have been evaluated. Eight pharmacies participated in the project: a capillary specimen collected by the pharmacist and, simultaneously, a lithium-heparin sample drawn by a physician of laboratory medicine for the pharmacy customers (n=106) were analyzed in the pharmacy and in the laboratory, respectively. Glucose, cholesterol, HDL-cholesterol, triglycerides, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, were measured using: Reflotron, n=5; Samsung, n=1; Cardiocheck PA, n=1; Cholestech LDX, n=1 and Cobas 8000. The POCT analytical performance only (phase 2) were evaluated testing, in pharmacies and in the laboratory, the lithium heparin samples from a female drawn fasting daily in a week, and a control sample containing high concentrations of glucose, cholesterol and triglycerides. For all parameters, except triglycerides, the slopes showed a satisfactory correlation. For triglycerides, a median value higher in POCT in comparison to the laboratory (1.627 mmol/L vs. 0.950 mmol/L) has been observed. The agreement in the subjects classification, demonstrates that for glucose, 70% of the subjects show concentrations below the POCT recommended level (5.8-6.1 mmol/L), while 56% are according to the laboratory limit (<5.6 mmol/L). Total cholesterol exhibits a similar trend while POCT triglycerides show a greater percentage of increased values (21% vs. 9%). The reduction in triglycerides bias (phase 2) suggests that differences between POCT and central laboratory is attributable to a pre-analytical problem. The results confirm the acceptable analytical performance of POCT pharmacies and specific criticisms in the pre- and post-analytical phases.

  15. Diagnostic testing for Clostridium difficile in Italian microbiological laboratories.

    PubMed

    Spigaglia, Patrizia; Barbanti, Fabrizio; Morandi, Matteo; Moro, Maria Luisa; Mastrantonio, Paola

    2016-02-01

    A laboratory diagnosis survey of Clostridium difficile infection (CDI) was performed in Italy in 2012-2013. Questionnaires from 278 healthcare settings from 15 regions of Italy were collected and analysed. Eighty seven percent of the laboratories declared to routinely perform CDI diagnosis, 99% of them only after the clinician's request. Among the 216 laboratories providing information on the size of the hospitals in which they were located, 65 had more than 500 beds (large hospitals), while 151 had less than 500 beds (small hospitals). The average percentage of positive tests for C. difficile toxins was 12.2%. Almost half of the laboratories (42%) used immunoenzymatic assay (EIA) for Tox A/B as a stand-alone method, while only 34% used an algorithm for CDI as indicated by the European guidelines. A low percentage of laboratories performed molecular assays or C. difficile culture, 25% and 29%, respectively. Most laboratories (161/278) declared to type C. difficile strains, the majority in collaboration with a reference laboratory. Among the 103 C. difficile clinical isolates collected during the study, 31 different PCR-ribotypes were identified. PCR-ribotype 356/607 (27%) was predominant, followed by 018 (12%). These two PCR-ribotypes show 87.5% of similarity in ribotyping profile. PCR-ribotypes 027 and 078 represented 8% and 4% of the strains, respectively. Four PCR-ribotypes (027, 033, 078 and 126) were positive for the binary toxin CDT. In particular, PCR-ribotype 033 produces only CDT, and it has recently been associated with symptomatic cases. The majority of strains were multidrug resistant. In particular, all strains PCR-ribotypes 356/607 and 018 were resistant to moxifloxacin, rifampicin, erythromycin and clindamycin. The results obtained highlight the need to raise awareness to the microbiological diagnosis of CDI among clinicians and to implement and harmonize diagnostic methods for CDI in Italian laboratories in the perspective of a future national

  16. Containment testing for occupied and unoccupied laboratory chemical hoods

    SciTech Connect

    Greenley, P.L.; DiBerardinis, L.J.; Lorch, F.A.

    1999-07-01

    Containment of hazards in a laboratory chemical hood is based on the principle that air drawn through the face area of the hood is sufficient to overcome the many challenges at or near the opening. Challenges to overcome include, but are not limited to, air velocities near the hood, movement of the researcher, people walking past the hood, location of equipment inside the hood, size of the sash opening, and the shape and configuration of entrance conditions. To overcome these challenges, a sufficient face velocity must be maintained. Determining that proper face velocity must be maintained. Determining that proper face velocity for a given hood should be resolved by the system designer, facility safety officer, and researcher with these and other issues in mind. This research tests for containment at 100 feet per minute (fpm) face velocity on occupied hoods and tests the same hoods for containment at the reduced velocity of 60 fpm when unoccupied. Three laboratory chemical hoods of different sizes with several ash positions are used. The test results show that under ideal conditions in a test laboratory, an unoccupied hood (without a manikin) at 60 fpm contains as good as, if not better than, an occupied hood (with a manikin) at 100 fpm, as measured by the tracer gas tests specified in ANSI/ASHRAE 110-1995, Method of Testing Performance of Laboratory Fume Hoods (ASHRAE 1995). Further testing is needed to determine if this relationship is the same under conditions of actual use, i.e., cluttered hoods and presence of cross-drafts.

  17. The transportable heavy-duty engine emissions testing laboratory

    SciTech Connect

    Not Available

    1991-05-01

    West Virginia University has designed and constructed a Transportable Emissions Testing Laboratory for measuring emissions from heavy duty vehicles, such as buses and trucks operating on conventional and alternative fuels. The laboratory facility can be transported to a test site located at, or nearby, the home base of the vehicles to be tested. The laboratory has the capability of measuring vehicle emissions as the vehicle is operated under either transient or steady state loads and speeds. The exhaust emissions from the vehicle is sampled and the levels of the constituents of the emission are measured. The laboratory consists of two major units; a power absorber unit and an emissions measurement unit. A power absorber unit allows for the connection of a dynamic load to the drive train of the vehicle so that the vehicle can be driven'' through a test cycle while actually mounted on a stationary test bed. The emissions unit contains instrumentation and equipment which allows for the dilution of the vehicle's exhaust with air. The diluteed exhaust is sampled and analyzed to measure the level of concentration of those constituents which have been identified to have impact on the clean environment. Sampling probes withdraw diluted exhaust which is supplied to a number of different exhaust gas analysis instruments. The exhaust gas analysis instruments have the capability to measure the levels of the following exhaust gas constituents: carbon monoxide (CO), carbon dioxide (CO{sub 2}), oxides of nitrogen (NO{sub x}), unburned hydrocarbons (HC), formaldehyde (HCHO), methane and particulate matter. Additional instruments or sampling devices can be installed whenever measurements of additional constituents are desired. A computer based, data acquisition system is used to continuously monitor a wide range of parameters important to the operation of the test and to record the test results.

  18. [Patient satisfaction in a laboratory test collection unit].

    PubMed

    de Moura, Gisela Maria Schebella Souto; Hilleshein, Eunice Fabiani; Schardosim, Juliana Machado; Delgado, Kátia Simone

    2008-06-01

    This exploratory descriptive study aimed at identifying customer satisfaction attributes in the field of laboratory tests. Data were collected in 2006, using 104 interviews in a laboratorial unit inside a teaching hospital, using the critical incident technique, and submitted to content analysis. Three attribute categories were identified: time spent in waiting for care, interpersonal contact, and technical skills. These results subsidize the assessment of the current satisfaction survey tool, and point to its reformulation. They also allow the identification of improvement needs in customer attention, and provide elements to be taken into account in personnel selection, training programs, personnel performance assessment.

  19. NASA Glenn's Acoustical Testing Laboratory Awarded Accreditation by the National Voluntary Laboratory Accreditation Program

    NASA Technical Reports Server (NTRS)

    Akers, James C.; Cooper, Beth A.

    2004-01-01

    NASA Glenn Research Center's Acoustical Testing Laboratory (ATL) provides a comprehensive array of acoustical testing services, including sound pressure level, sound intensity level, and sound-power-level testing per International Standards Organization (ISO)1 3744. Since its establishment in September 2000, the ATL has provided acoustic emission testing and noise control services for a variety of customers, particularly microgravity space flight hardware that must meet International Space Station acoustic emission requirements. The ATL consists of a 23- by 27- by 20-ft (height) convertible hemi/anechoic test chamber and a separate sound-attenuating test support enclosure. The ATL employs a personal-computer-based data acquisition system that provides up to 26 channels of simultaneous data acquisition with real-time analysis (ref. 4). Specialized diagnostic tools, including a scanning sound-intensity system, allow the ATL's technical staff to support its clients' aggressive low-noise design efforts to meet the space station's acoustic emission requirement. From its inception, the ATL has pursued the goal of developing a comprehensive ISO 17025-compliant quality program that would incorporate Glenn's existing ISO 9000 quality system policies as well as ATL-specific technical policies and procedures. In March 2003, the ATL quality program was awarded accreditation by the National Voluntary Laboratory Accreditation Program (NVLAP) for sound-power-level testing in accordance with ISO 3744. The NVLAP program is administered by the National Institutes of Standards and Technology (NIST) of the U.S. Department of Commerce and provides third-party accreditation for testing and calibration laboratories. There are currently 24 NVLAP-accredited acoustical testing laboratories in the United States. NVLAP accreditation covering one or more specific testing procedures conducted in accordance with established test standards is awarded upon successful completion of an intensive

  20. Identifying the Clinical Laboratory Tests from Unspecified "Other Lab Test" Data for Secondary Use.

    PubMed

    Pan, Xuequn; Cimino, James J

    2015-01-01

    Clinical laboratory results are stored in electronic health records (EHRs) as structured data coded with local or standard terms. However, laboratory tests that are performed at outside laboratories are often simply labeled "outside test" or something similar, with the actual test name in a free-text result or comment field. After being aggregated into clinical data repositories, these ambiguous labels impede the retrieval of specific test results. We present a general multi-step solution that can facilitate the identification, standardization, reconciliation, and transformation of such test results. We applied our approach to data in the NIH Biomedical Translational Research Information System (BTRIS) to identify laboratory tests, map comment values to the LOINC codes that will be incorporated into our Research Entities Dictionary (RED), and develop a reference table that can be used in the EHR data extract-transform-load (ETL) process.

  1. Testing hygrometers used in cytogenetics laboratories for metaphase preparation.

    PubMed

    Hartley, Thomas; Dun, Karen

    2011-07-01

    This protocol describes procedures for checking small laboratory hygrometers for accuracy at three relative humidity (rh) levels. The work arose out of the need to provide laboratory assessors with documentary evidence that the hygrometer used to monitor humidity in the vicinity of the laboratory where medical cytogenetics testing slides are prepared and dried in the ambient environment is reproducible and sufficiently accurate. The procedure is based upon the physicochemical principle that when water or certain saturated salt solutions are placed into a sealed environment, the humidity will equilibrate to well defined levels. We choose to check our hygrometers at three points: 95%, 75%, and 33% rh, using distilled water, saturated sodium chloride solution, and saturated magnesium chloride solution, respectively. Our results have demonstrated that the procedure is convenient and of sufficient accuracy to be fit for this annual hygrometer validation purpose. The procedure takes 24 hr per relative humidity point checked.

  2. Thermocouple Calibration and Accuracy in a Materials Testing Laboratory

    NASA Technical Reports Server (NTRS)

    Lerch, B. A.; Nathal, M. V.; Keller, D. J.

    2002-01-01

    A consolidation of information has been provided that can be used to define procedures for enhancing and maintaining accuracy in temperature measurements in materials testing laboratories. These studies were restricted to type R and K thermocouples (TCs) tested in air. Thermocouple accuracies, as influenced by calibration methods, thermocouple stability, and manufacturer's tolerances were all quantified in terms of statistical confidence intervals. By calibrating specific TCs the benefits in accuracy can be as great as 6 C or 5X better compared to relying on manufacturer's tolerances. The results emphasize strict reliance on the defined testing protocol and on the need to establish recalibration frequencies in order to maintain these levels of accuracy.

  3. Laboratory test method for dirt pickup resistance and stain removal

    NASA Astrophysics Data System (ADS)

    Ren, Shiwei; Zheng, Xueying; Liu, Yi; Jiang, Quan

    2017-03-01

    The pollution characteristics of current atmospheric particulates was summarized in the present investigation. The composition and proportion of the pollution sources used for dirt pickup resistance and stain removal test were adjusted, and the pollution sources used for new type dirt pickup resistance and stain removal test produced. In addition, a new dirt pickup method was adopted, and a set of new type laboratory dirt pickup resistance and stain removal tests developed by taking comprehensive consideration of the existing state and dirt pickup mode of actual atmospheric particulates. It verifies the rationality, feasibility and effectiveness of new test methods for dirt pickup resistance and stain removal based on the contrast test over the new and old test methods.

  4. Laboratory testing of West Valley reference 6 glass

    SciTech Connect

    Ebert, W.L.

    1995-07-01

    A series of laboratory tests is being conducted to characterize the corrosion of West Valley reference 6 glass (WV6) and to provide parametric values for modeling its long-term durability. Models require measurement of the corrosion rate in the absence of corrosion products and in fluids that are {open_quotes}saturated{close_quotes} with corrosion products, and the identification of alteration phases. Corrosion rates in dilute and saturated conditions were measured using MCC-1 and PCT tests, respectively. Vapor hydration tests were performed to generate secondary phases. The PCT tests show the WV6 glass to be more durable than SRL EA, SRL 202, and HW-39-1 glasses. Vapor hydration tests show weeksite (a uranyl silicate), a potassium-bearing zeolite, analcime, potassium feldspar, a calcium silicate phase, and lithium phosphate to form as WV6 glass corrodes. Test results are presented and their relevance to long-term performance discussed.

  5. Automated cognitive testing of monkeys in social groups yields results comparable to individual laboratory based testing

    PubMed Central

    Gazes, Regina Paxton; Brown, Emily Kathryn; Basile, Benjamin M.; Hampton, Robert R.

    2013-01-01

    Cognitive abilities likely evolved in response to specific environmental and social challenges and are therefore expected to be specialized for the life history of each species. Specialized cognitive abilities may be most readily engaged under conditions that approximate the natural environment of the species being studied. While naturalistic environments might therefore have advantages over laboratory settings for cognitive research, it is difficult to conduct certain types of cognitive tests in these settings. We implemented methods for automated cognitive testing of monkeys (Macaca mulatta) in large social groups (Field station) and compared the performance to that of laboratory housed monkeys (Laboratory). The Field station animals shared access to four touch screen computers in a large naturalistic social group. Each Field station subject had an RFID chip implanted in each arm for computerized identification and individualized assignment of cognitive tests. The Laboratory group was housed and tested in a typical laboratory setting, with individual access to testing computers in their home cages. Monkeys in both groups voluntarily participated at their own pace for food rewards. We evaluated performance in two visual psychophysics tests, a perceptual classification test, a transitive inference test, and a delayed matching to sample memory test. Despite differences in housing, social environment, age, and sex, monkeys in the two groups performed similarly in all tests. Semi-free ranging monkeys living in complex social environments are therefore viable subjects for cognitive testing designed to take advantage of the unique affordances of naturalistic testing environments. PMID:23263675

  6. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do laboratories test for? As a laboratory, you must test for the following five drugs or classes of drugs in a DOT drug... 49 Transportation 1 2011-10-01 2011-10-01 false What drugs do laboratories test for? 40.85 Section...

  7. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do laboratories test for? As a laboratory, you must test for the following five drugs or classes of drugs in a DOT drug... 49 Transportation 1 2012-10-01 2012-10-01 false What drugs do laboratories test for? 40.85 Section...

  8. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do laboratories test for? As a laboratory, you must test for the following five drugs or classes of drugs in a DOT drug... 49 Transportation 1 2014-10-01 2014-10-01 false What drugs do laboratories test for? 40.85 Section...

  9. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do laboratories test for? As a laboratory, you must test for the following five drugs or classes of drugs in a DOT drug... 49 Transportation 1 2010-10-01 2010-10-01 false What drugs do laboratories test for? 40.85 Section...

  10. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do laboratories test for? As a laboratory, you must test for the following five drugs or classes of drugs in a DOT drug... 49 Transportation 1 2013-10-01 2013-10-01 false What drugs do laboratories test for? 40.85 Section...

  11. Laboratory or Field Tests for Evaluating Firefighters' Work Capacity?

    PubMed Central

    Lindberg, Ann-Sofie; Oksa, Juha; Malm, Christer

    2014-01-01

    Muscle strength is important for firefighters work capacity. Laboratory tests used for measurements of muscle strength, however, are complicated, expensive and time consuming. The aims of the present study were to investigate correlations between physical capacity within commonly occurring and physically demanding firefighting work tasks and both laboratory and field tests in full time (N = 8) and part-time (N = 10) male firefighters and civilian men (N = 8) and women (N = 12), and also to give recommendations as to which field tests might be useful for evaluating firefighters' physical work capacity. Laboratory tests of isokinetic maximal (IM) and endurance (IE) muscle power and dynamic balance, field tests including maximal and endurance muscle performance, and simulated firefighting work tasks were performed. Correlations with work capacity were analyzed with Spearman's rank correlation coefficient (rs). The highest significant (p<0.01) correlations with laboratory and field tests were for Cutting: IE trunk extension (rs = 0.72) and maximal hand grip strength (rs = 0.67), for Stairs: IE shoulder flexion (rs = −0.81) and barbell shoulder press (rs = −0.77), for Pulling: IE shoulder extension (rs = −0.82) and bench press (rs = −0.85), for Demolition: IE knee extension (rs = 0.75) and bench press (rs = 0.83), for Rescue: IE shoulder flexion (rs = −0.83) and bench press (rs = −0.82), and for the Terrain work task: IE trunk flexion (rs = −0.58) and upright barbell row (rs = −0.70). In conclusion, field tests may be used instead of laboratory tests. Maximal hand grip strength, bench press, chin ups, dips, upright barbell row, standing broad jump, and barbell shoulder press were strongly correlated (rs≥0.7) with work capacity and are therefore recommended for evaluating firefighters work capacity. PMID:24614596

  12. Space Electric Research Test in the Electric Propulsion Laboratory

    NASA Image and Video Library

    1964-06-21

    Technicians prepare the Space Electric Research Test (SERT-I) payload for a test in Tank Number 5 of the Electric Propulsion Laboratory at the National Aeronautics and Space Administration (NASA) Lewis Research Center. Lewis researchers had been studying different methods of electric rocket propulsion since the mid-1950s. Harold Kaufman created the first successful engine, the electron bombardment ion engine, in the early 1960s. These electric engines created and accelerated small particles of propellant material to high exhaust velocities. Electric engines have a very small amount of thrust, but once lofted into orbit by workhorse chemical rockets, they are capable of small, continuous thrust for periods up to several years. The electron bombardment thruster operated at a 90-percent efficiency during testing in the Electric Propulsion Laboratory. The package was rapidly rotated in a vacuum to simulate its behavior in space. The SERT-I mission, launched from Wallops Island, Virginia, was the first flight test of Kaufman’s ion engine. SERT-I had one cesium engine and one mercury engine. The suborbital flight was only 50 minutes in duration but proved that the ion engine could operate in space. The Electric Propulsion Laboratory included two large space simulation chambers, one of which is seen here. Each uses twenty 2.6-foot diameter diffusion pumps, blowers, and roughing pumps to remove the air inside the tank to create the thin atmosphere. A helium refrigeration system simulates the cold temperatures of space.

  13. [Symptom based approaches in point of care laboratory testing].

    PubMed

    Risch, Lorenz; Senn, Oliver

    2015-02-01

    Point of care testing (POCT) allows, among others, for efficient care of patients presenting with acute problems to primary care physicians. A combination of clinical information and laboratory results enables physicians to obtain posttest probabilities for the presence or absence of a specific disease. In order to rule in or rule out a disease, the physician has to know both the pretest probability for a disease in a patient as well as the analytical and diagnostic characteristics of the employed test. Pretest probability can be assessed by scores or by personal judgment of the experienced clinician. This article presents the basics of the Bayes theorem together with its clinical applications in acute scenarios in primary health care. These scenarios comprise the use of D-Dimer testing in ruling out venous thromboembolism, rapid testing of group A streptococci in the setting of acute pharyngitis, troponin testing in patients with thoracic pain, c-reactive protein (CRP) testing in patients presenting with acute cough and fever, as well as urine dipstick testing in suspected urinary tract infection. These examples illustrate, that risk stratification before conducting laboratory analysis is of utmost importance in order to obtain valid results for ruling in or ruling out diseases in POCT-settings.

  14. Laboratory diagnosis and interpretation of tests for syphilis.

    PubMed Central

    Larsen, S A; Steiner, B M; Rudolph, A H

    1995-01-01

    The lack of a method for demonstrating the presence of Treponema pallidum by growth necessitates the use of alternative methods. Traditionally, these methods are divided into direct detection methods (animal inoculation, dark-field microscopy, etc.) and serologic tests for the presence of patient antibody against T. pallidum. Serologic methods are further divided into two classes. One class, the nontreponemal tests, detects antibodies to lipoidal antigens present in either the host or T. pallidum; examples are the Venereal Disease Research Laboratory and rapid plasma reagin and tests. Reactivity in these tests generally indicates host tissue damage that may not be specific for syphilis. Because these tests are easy and inexpensive to perform, they are commonly used for screening, and with proper clinical signs they are suggestive of syphilis. The other class of test, the treponemal tests, uses specific treponemal antigens. Confirmation of infection requires a reactive treponemal test. Examples of the treponemal tests are the microhemagglutination assay for antibodies to T. pallidum and the fluorescent treponemal antibody absorption test. These tests are more expensive and complicated to perform than the nontreponemal tests. On the horizon are a number of direct antigen, enzyme-linked immunosorbent assay, and PCR techniques. Several of these techniques have shown promise in clinical trials for the diagnosis of congenital syphilis and neurosyphilis that are presently difficult to diagnose. PMID:7704889

  15. Laboratory testing of high energy density capacitors for electric vehicles

    NASA Astrophysics Data System (ADS)

    Burke, A. F.

    1991-10-01

    Laboratory tests of advanced, high energy density capacitors in the Battery Test Laboratory of the Idaho National Engineering Laboratory have been performed to investigate their suitability for load-leveling the battery in an electric vehicle. Two types of devices were tested- 3 V, 70 Farad, spiral wound, carbon-based, single cell devices and 20 V, 3. 5 Farad, mixed-oxide, multi-cell bipolar devices. The energy density of the devices, based on energy stored during charge to the rated voltage, was found to be 1-2 W/kg, which agreed well with that claimed by the manufacturers. Constant power discharge tests were performed at power densities up to 1500 W/kg. Discharges at higher power densities could have been performed had equipment been available to maintain constant power during discharges of less than one second. It was found that the capacitance of the devices were rate dependent with the rate dependency of the carbon-based devices being higher than that of the mixed-oxide devices. The resistance of both types of devices were relatively low being 20-30 milliohms. Testing done in the study showed that the advanced high energy density capacitors can be charged and discharged over cycles which approximate the duty cycle that would be encountered if the devices are used to load-level the battery in an electric vehicle. Thermal tests of the advanced capacitors in an insulated environment using the PSFUDS cycle showed the devices do not overheat with their temperatures increasing only 4-5 C for tests that lasted 5-7 hours.

  16. Preliminary test results with a Stirling Laboratory Research Engine

    NASA Technical Reports Server (NTRS)

    Hoehn, F. W.; Nguyen, B. D.; Schmit, D. D.

    1979-01-01

    The Jet Propulsion Laboratory has designed, assembled, and initiated testing of a Stirling Laboratory Research Engine (SLRE). This preprototype engine provides a research tool to support the development of a broad range of analytical modeling and experimental efforts. The SLRE is a horizontally opposed, two-piston, single-acting Stirling engine with a split crankshaft drive mechanism. The paper discusses the preliminary results obtained during engine motoring tests and compares these results with two different analytical prediction models. Comparisons are made between experiment, the classical Schmidt analysis, and the JPL Stirling Cycle Analysis Model (SCAM). SCAM is a computerized one-dimensional, cyclic, compressible flow model of the SLRE and consists of a compilation of individual component subroutines. The formulation and current state of development of the SCAM program is briefly described.

  17. TEST PLAN FOR MONITORING COOLING COILS IN A LABORATORY SETTING

    SciTech Connect

    Don B. Shirey, III

    2002-04-01

    The objective of this research project is to understand and quantify the moisture removal performance of cooling coils at part-load conditions. The project will include a comprehensive literature review, detailed measurement of cooling coil performance in a laboratory facility, monitoring cooling systems at several field test sites, and development/validation of engineering models that can be used in energy calculations and building simulations. This document contains the detailed test plan for monitoring cooling coil performance in a laboratory setting. Detailed measurements will be taken on up to 10 direct expansion (DX) and chilled water cooling coils in various configurations to understand the impact of coil geometry and operating conditions on transient moisture condensation and evaporation.

  18. Radioactive material package testing capabilities at Sandia National Laboratories

    SciTech Connect

    Uncapher, W.L.; Hohnstreiter, G.F.

    1995-12-31

    Evaluation and certification of radioactive and hazardous material transport packages can be accomplished by subjecting these packages to normal transport and hypothetical accident test conditions. The regulations allow package designers to certify packages using analysis, testing, or a combination of analysis and testing. Testing can be used to substantiate assumptions used in analytical models and to demonstrate package structural and thermal response. Regulatory test conditions include impact, puncture, crush, penetration, water spray, immersion, and thermal environments. Testing facilities are used to simulate the required test conditions and provide measurement response data. Over the past four decades, comprehensive testing facilities have been developed at Sandia National Laboratories to perform a broad range of verification and certification tests on hazardous and radioactive material packages or component sections. Sandia`s facilities provide an experience base that has been established during the development and certification of many package designs. These unique facilities, along with innovative instrumentation data collection capabilities and techniques, simulate a broad range of testing environments. In certain package designs, package testing can be an economical alternative to complex analysis to resolve regulatory questions or concerns.

  19. Weld Tests Conducted by the Idaho National Laboratory

    SciTech Connect

    Larry Zirker; Lance Lauerhass; James Dowalo

    2007-02-01

    During the fiscal year of 2006, the Idaho National Laboratory (INL) performed many tests and work relating to the Mobile Melt-Dilute (MMD) Project components. Tests performed on the Staubli quick disconnect fittings showed promising results, but more tests were needed validate the fittings. Changes were made to the shield plug design—reduced the closure groove weld depth between the top of the canister and the top plate of the shielding plug from 0.5-in to 0.375-in deep. Other changes include a cap to cover the fitting, lifting pintle and welding code citations on the prints. Tests conducted showed stainless steel tubing, with 0.25-in, 0.375-in, and 0.5-in diameters, all with 0.035-in wall thickness, could be pinch seal welded using commercially available resistance welding equipment. Subsequent testing showed that these welds could be real-time inspected with ultrasonic inspection methods.

  20. Hydraulic and Hydromechanical Laboratory Testing of Large Crystalline Rock Cores

    NASA Astrophysics Data System (ADS)

    Thörn, Johan; Ericsson, Lars O.; Fransson, Åsa

    2015-01-01

    In this paper, fracture stiffness in rock samples is determined by means of hydromechanical laboratory testing. The aim is three-fold: to develop a procedure for sampling, to update testing equipment and to relate fracture stiffness to the geological history (e.g., stress history and fracture infillings). The hydraulic properties of twenty rock cores (diameter 190 mm, c. 100 mm high) from the Äspö Hard Rock Laboratory were tested in a permeameter cell under different isotropic pressures up to 2.5 MPa. The flow rate through individual fracture samples was recorded. Four of the samples were re-tested in the permeameter cell using an updated hydromechanical procedure with deformation measurement across the fracture. Four load cycles of gradually increasing cell pressure were applied, resulting in a clearly observed hysteresis effect in the first and second cycles. Hydraulic aperture changes calculated using the cubic law were compared with their mechanical equivalents. The aperture changes followed similar trends, although these differed between the samples. Fracture stiffness was determined from the tests, and the stiffness to hydraulic aperture relationship was found to follow previously published patterns linked to the storativity of fractures. Differences in stiffness are explained in the context of the geological history of individual samples, particularly their stress history. The paper presents a conceptualisation of the stiffness behaviour, which includes flow properties, geometric properties and the geological stress history of the tested samples.

  1. Federal laboratory nondestructive testing research and development applicable to industry

    SciTech Connect

    Smith, S.A.; Moore, N.L.

    1987-02-01

    This document presents the results of a survey of nondestructive testing (NDT) and related sensor technology research and development (R and D) at selected federal laboratories. Objective was to identify and characterize NDT activities that could be applied to improving energy efficiency and overall productivity in US manufacturing. Numerous federally supported R and D programs were identified in areas such as acoustic emissions, eddy current, radiography, computer tomography and ultrasonics. A Preliminary Findings Report was sent to industry representatives, which generated considerable interest.

  2. System Integration Laboratory test plan (RADL Item 6-4)

    SciTech Connect

    Not Available

    1980-05-01

    A general demonstration test plan is provided for the activities to be accomplished at the SFDI Systems Integration Laboratory (SIL) at Huntington Beach. The Master Control System (MCS), the Subsystem Distributed Process Control (SDPC), the Signal Conditioning Units (SCU), and Redline Units (RLU) from the Receiver Subsystem (RS) and the Thermal Storage Subsystem (TSS) and other external interface operational functions shall be integrated and functionally demonstrated. The overall plan for the SIL activities is presented.

  3. Proposals for ORNL (Oak Ridge National Laboratory) support to Tiber LLNL (Lawrence Livermore National Laboratory). [Engineering Test Reactor

    SciTech Connect

    Berry, L.A.; Rosenthal, M.W.; Saltmarsh, M.J.; Shannon, T.E.; Sheffield, J.

    1987-01-27

    This document describes the interests and capabilities of Oak Ridge National Laboratory in their proposals to support the Lawrence Livermore National Laboratory (LLNL) Engineering Test Reactor (ETR) project. Five individual proposals are cataloged separately. (FI)

  4. Prediction of sprint triathlon performance from laboratory tests.

    PubMed

    Van Schuylenbergh, R; Eynde, B Vanden; Hespel, P

    2004-01-01

    This study investigated whether sprint triathlon performance can be adequately predicted from laboratory tests. Ten triathletes [mean (SEM), age 21.8 (0.3) years, height 179 (2) cm, body mass 67.5 (2.5) kg] performed two graded maximal exercise test in random order, either on their own bicycle which was mounted on an ergometer or on a treadmill, to determine their peak oxygen consumption ( VO(2)peak). Furthermore, they participated in two to three 30-min constant-load tests in both swimming, cycling and running to establish their maximal lactate steady state (MLSS) in each exercise mode. Swim tests were performed in a 25-m swimming pool (water temperature 27 degrees C). During each test heart rate (HR), power output (PO) or running/swimming speed and blood lactate concentration (BLC) were recorded at regular intervals. Oxygen uptake ( VO(2)) was continuously measured during the graded tests. Two weeks after the laboratory tests all subjects competed in a triathlon race (500 m swim, 20-km bike, 5-km run) [1 h 4 min 45 s (1 min 38 s)]. Peak HR was 7 beats.min(-1) lower in the graded cycle test than in the treadmill test ( p<0.05) at similar peak BLC (approximately 10 mmol.l(-1)) and VO(2)peak (approximately 5 L.min(-1)). High correlations were found between VO(2)peak during cycling ( r=-0.71, p<0.05) or running ( r=-0.69, p<0.05) and triathlon performance. Stepwise multiple regression analysis showed that running speed and swimming speed at MLSS, together with BLC in running at MLSS, yielded the best prediction of performance [1 h 5 min 18 s (1 min 49 s)]. Thus, our data indicate that exercise tests aimed to determine MLSS in running and swimming allow for a precise estimation of sprint triathlon performance.

  5. The Lincoln Laboratory-Aerospace Medical Research Laboratory digital speech test facility

    NASA Astrophysics Data System (ADS)

    Tierney, J.; Schecter, H.

    1984-05-01

    A narrowband digital speech communication test facility has been established and operates between Lincoln Laboratory and the Wright-Patterson Aerospace Medical Research Laboratory. Noise fields simulating the acoustic environments of E3A and F-15 aircraft are established and Air Force personnel use the link operating at 2400 bps with a vocoder designed at Lincoln Laboratory, and a commercial telephone line modem. The facility includes a digital signal processing computer which can introduce bit errors and delay into the transmit and receive data. Communication scenarios are used to exercise the vocoder-modem channel with the dynamics and vocabulary of typical operational exchanges. Answers to a standard questionnaire provide acceptability data for the 2400 bps JTIDS class 2 voice channel. For the tests run so far, the 2400 bps voice is acceptable in the sense of positive user response to the questionnaire. Further testing using error and delay simulations will follow. An F-15 to F-15 link will be simulated at AMRL using a pair of vocoders operating back-to-back and in separate noise chambers.

  6. Laboratory Diagnostics Market in East Africa: A Survey of Test Types, Test Availability, and Test Prices in Kampala, Uganda

    PubMed Central

    Schroeder, Lee F.; Elbireer, Ali; Jackson, J. Brooks; Amukele, Timothy K.

    2015-01-01

    Background Diagnostic laboratory tests are routinely defined in terms of their sensitivity, specificity, and ease of use. But the actual clinical impact of a diagnostic test also depends on its availability and price. This is especially true in resource-limited settings such as sub-Saharan Africa. We present a first-of-its-kind report of diagnostic test types, availability, and prices in Kampala, Uganda. Methods Test types (identity) and availability were based on menus and volumes obtained from clinical laboratories in late 2011 in Kampala using a standard questionnaire. As a measure of test availability, we used the Availability Index (AI). AI is the combined daily testing volumes of laboratories offering a given test, divided by the combined daily testing volumes of all laboratories in Kampala. Test prices were based on a sampling of prices collected in person and via telephone surveys in 2015. Findings Test volumes and menus were obtained for 95% (907/954) of laboratories in Kampala city. These 907 laboratories offered 100 different test types. The ten most commonly offered tests in decreasing order were Malaria, HCG, HIV serology, Syphilis, Typhoid, Urinalysis, Brucellosis, Stool Analysis, Glucose, and ABO/Rh. In terms of AI, the 100 tests clustered into three groups: high (12 tests), moderate (33 tests), and minimal (55 tests) availability. 50% and 36% of overall availability was provided through private and public laboratories, respectively. Point-of-care laboratories contributed 35% to the AI of high availability tests, but only 6% to the AI of the other tests. The mean price of the most commonly offered test types was $2.62 (range $1.83–$3.46). Interpretation One hundred different laboratory test types were in use in Kampala in late 2011. Both public and private laboratories were critical to test availability. The tests offered in point-of-care laboratories tended to be the most available tests. Prices of the most common tests ranged from $1

  7. Dementia workup. Deciding on laboratory testing for the elderly.

    PubMed Central

    Frank, C.

    1998-01-01

    OBJECTIVE: To review Canadian Consensus Conference on the Assessment of Dementia (CCCAD) guidelines for laboratory evaluation of dementia, and to make recommendations to family physicians based on these guidelines and other literature. DATA SOURCES: English-language data sources from 1992 to March 1997 were searched on MEDLINE using the MeSH headings dementia, dementia/diagnosis, and cognition. Key words relating to specific laboratory tests or conditions, such as neurosyphilis or vitamin B12, were also used. STUDY SELECTION: Original research articles using prospective and retrospective methods were accepted. Articles reviewing the general investigation of potentially reversible dementia were included, as were articles looking at the sensitivity, specificity, and utility of investigations for specific conditions causing dementia. SYNTHESIS: Family physicians are not always aware of CCCAD recommendations for the investigation of dementia. There was C-level evidence for use of CCCAD core investigations (complete blood count and electrolyte, glucose, calcium, and thyroid levels) and for tests to be done "when the clinical situation warrants" (B12 levels, computed tomography scan of the head, and testing for syphilis). CONCLUSIONS: The CCCAD guidelines were supported by most literature on the workup of dementia. Prospective cohort studies suggest use of clinical judgment in ordering laboratory investigations. No controlled trials were available, and most recommendations arose from consensus rather than from research evidence. The prevalence of reversible dementias is likely lower than previously believed, which further supports a selective approach to investigations. Identification of reversible causes and exacerbating factors is still the goal. PMID:9678278

  8. Biometric identification devices -- Laboratory testing vs. real life

    SciTech Connect

    Ahrens, J.S.

    1997-05-01

    For over fifteen years Sandia National Laboratories has been involved in laboratory testing of biometric identification devices. The key concept of biometric identification devices is the ability for the system to identify some unique aspect of the individual rather than some object a person may be carrying or some password they are required to know. Tests were conducted to verify manufacturer`s performance claims, to determine strengths/weaknesses of devices, and to determine devices that meet the US Department of energy`s needs. However, during recent field installation, significantly different performance was observed than was predicted by laboratory tests. Although most people using the device believed it operated adequately, the performance observed was over an order of magnitude worse than predicted. The search for reasons behind this gap between the predicted and the actual performance has revealed many possible contributing factors. As engineers, the most valuable lesson to be learned from this experience is the value of scientists and engineers with (1) common sense, (2) knowledge of human behavior, (3) the ability to observe the real world, and (4) the capability to realize the significant differences between controlled experiments and actual installations.

  9. Hydrogen Field Test Standard: Laboratory and Field Performance

    PubMed Central

    Pope, Jodie G.; Wright, John D.

    2015-01-01

    The National Institute of Standards and Technology (NIST) developed a prototype field test standard (FTS) that incorporates three test methods that could be used by state weights and measures inspectors to periodically verify the accuracy of retail hydrogen dispensers, much as gasoline dispensers are tested today. The three field test methods are: 1) gravimetric, 2) Pressure, Volume, Temperature (PVT), and 3) master meter. The FTS was tested in NIST's Transient Flow Facility with helium gas and in the field at a hydrogen dispenser location. All three methods agree within 0.57 % and 1.53 % for all test drafts of helium gas in the laboratory setting and of hydrogen gas in the field, respectively. The time required to perform six test drafts is similar for all three methods, ranging from 6 h for the gravimetric and master meter methods to 8 h for the PVT method. The laboratory tests show that 1) it is critical to wait for thermal equilibrium to achieve density measurements in the FTS that meet the desired uncertainty requirements for the PVT and master meter methods; in general, we found a wait time of 20 minutes introduces errors < 0.1 % and < 0.04 % in the PVT and master meter methods, respectively and 2) buoyancy corrections are important for the lowest uncertainty gravimetric measurements. The field tests show that sensor drift can become a largest component of uncertainty that is not present in the laboratory setting. The scale was calibrated after it was set up at the field location. Checks of the calibration throughout testing showed drift of 0.031 %. Calibration of the master meter and the pressure sensors prior to travel to the field location and upon return showed significant drifts in their calibrations; 0.14 % and up to 1.7 %, respectively. This highlights the need for better sensor selection and/or more robust sensor testing prior to putting into field service. All three test methods are capable of being successfully performed in the field and give

  10. TESTING OF THE RADBALL TECHNOLOGY AT SAVANNAH RIVER NATIONAL LABORATORY

    SciTech Connect

    Farfan, E.; Foley, T.

    2010-02-10

    The United Kingdom's National Nuclear Laboratory (NNL) has developed a remote, nonelectrical, radiation-mapping device known as RadBall (patent pending), which offers a means to locate and quantify radiation hazards and sources within contaminated areas of the nuclear industry. Positive results from initial deployment trials in nuclear waste reprocessing plants at Sellafield in the United Kingdom and the anticipated future potential use of RadBall throughout the U.S. Department of Energy Complex have led to the NNL partnering with the Savannah River National Laboratory (SRNL) to further test, underpin, and strengthen the technical performance of the technology. The study completed at SRNL addresses key aspects of the testing of the RadBall technology. The first set of tests was performed at Savannah River Nuclear Solutions Health Physics Instrument Calibration Laboratory (HPICL) using various gamma-ray sources and an x-ray machine with known radiological characteristics. The objective of these preliminary tests was to identify the optimal dose and collimator thickness. The second set of tests involved a highly contaminated hot cell. The objective of this testing was to characterize a hot cell with unknown radiation sources. The RadBall calibration experiments and hot cell deployment were successful in that for each trial radiation tracks were visible. The deployment of RadBall can be accomplished in different ways depending on the size and characteristics of the contaminated area (e.g., a hot cell that already has a crane/manipulator available or highly contaminated room that requires the use of a remote control device with sensor and video equipment to position RadBall). This report also presents SRNL-designed RadBall accessories for future RadBall deployment (a harness, PODS, and robot).

  11. Mars Science Laboratory Flight Software Boot Robustness Testing Project Report

    NASA Technical Reports Server (NTRS)

    Roth, Brian

    2011-01-01

    On the surface of Mars, the Mars Science Laboratory will boot up its flight computers every morning, having charged the batteries through the night. This boot process is complicated, critical, and affected by numerous hardware states that can be difficult to test. The hardware test beds do not facilitate testing a long duration of back-to-back unmanned automated tests, and although the software simulation has provided the necessary functionality and fidelity for this boot testing, there has not been support for the full flexibility necessary for this task. Therefore to perform this testing a framework has been build around the software simulation that supports running automated tests loading a variety of starting configurations for software and hardware states. This implementation has been tested against the nominal cases to validate the methodology, and support for configuring off-nominal cases is ongoing. The implication of this testing is that the introduction of input configurations that have yet proved difficult to test may reveal boot scenarios worth higher fidelity investigation, and in other cases increase confidence in the robustness of the flight software boot process.

  12. Mars Science Laboratory Flight Software Boot Robustness Testing Project Report

    NASA Technical Reports Server (NTRS)

    Roth, Brian

    2011-01-01

    On the surface of Mars, the Mars Science Laboratory will boot up its flight computers every morning, having charged the batteries through the night. This boot process is complicated, critical, and affected by numerous hardware states that can be difficult to test. The hardware test beds do not facilitate testing a long duration of back-to-back unmanned automated tests, and although the software simulation has provided the necessary functionality and fidelity for this boot testing, there has not been support for the full flexibility necessary for this task. Therefore to perform this testing a framework has been build around the software simulation that supports running automated tests loading a variety of starting configurations for software and hardware states. This implementation has been tested against the nominal cases to validate the methodology, and support for configuring off-nominal cases is ongoing. The implication of this testing is that the introduction of input configurations that have yet proved difficult to test may reveal boot scenarios worth higher fidelity investigation, and in other cases increase confidence in the robustness of the flight software boot process.

  13. 42 CFR 493.1481 - Condition: Laboratories performing high complexity testing; cytotechnologist.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; cytotechnologist. 493.1481 Section 493.1481 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1481 Condition: Laboratories performing high complexity testing; cytotechnologist. For the subspecialty...

  14. 42 CFR 493.1481 - Condition: Laboratories performing high complexity testing; cytotechnologist.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; cytotechnologist. 493.1481 Section 493.1481 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1481 Condition: Laboratories performing high complexity testing; cytotechnologist. For the subspecialty...

  15. Mobile Energy Laboratory energy-efficiency testing programs

    NASA Astrophysics Data System (ADS)

    Parker, G. B.; Currie, J. W.

    1991-09-01

    This report summarizes energy-efficiency testing activities applying the Mobile Energy Laboratory (MEL) testing capabilities during the first and second quarters of fiscal year (FY) 1991. The MELs, developed by the U.S. Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) and the Naval Energy and Environmental Support Activity (NEESA) for energy testing and energy conservation program support functions at Federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in Section 8 of the MEL Use Plan (PNL-6861) for semiannual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semiannually to establish priorities for energy-efficient testing applications using the MEL capabilities. The MEL Use Committee is composed of one representative each of the U.S. Department of Energy, U.S. Army, U.S. Air Force, U.S. Navy, and other Federal agencies.

  16. Mobile Energy Laboratory energy-efficiency testing programs

    SciTech Connect

    Parker, G.B.; Currie, J.W.

    1991-09-01

    This report summarizes energy-efficiency testing activities applying the Mobile Energy Laboratory (MEL) testing capabilities during the first and second quarters of fiscal year (FY) 1991. The MELs, developed by the US Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) and the Naval Energy and Environmental Support Activity (NEESA) for energy testing and energy conservation program support functions at federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in Section 8 of the MEL Use Plan (PNL-6861) for semiannual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semiannually to establish priorities for energy-efficient testing applications using the MEL capabilities. The MEL Use Committee is composed of one representative each of the US Department of Energy, US Army, US Air Force, US Navy, and other federal agencies.

  17. Construction of Cooler for New Propulsion Systems Laboratory Test Cells

    NASA Image and Video Library

    1969-11-21

    The 50-foot diameter primary cooler for the new Propulsion Systems Laboratory No. 3 and 4 facility constructed at the National Aeronautics and Space Administration (NASA) Lewis Research Center. In 1968, 20 years after planning began for the original Propulsion Systems Laboratory test chambers, No. 1 and 2, NASA Lewis began preparations to add two additional and more powerful chambers. The move coincided with the center’s renewed focus on aeronautics in 1966. The new 40-foot long and 24-foot diameter chambers were capable of testing engines twice as powerful any then in existence and significantly larger than those in the original two test chambers. After exiting the engine nozzle, the hot exhaust air passed through a 17-foot diameter water exhaust duct and the 50-foot diameter primary cooler. Twenty-seven hundred water-filled tubes inside the cooler reduced the temperature of the air flow as it passed between the tubes from 3000 to 600 °F. A spray cooler further reduced the temperature of the gases to 150 °F before they were sent to the Central Air Building. Excavations for the new facility were completed by October 1967, and the shell of the building was completed a year later. In September 1968, work began on the new test chambers and associated infrastructure. Construction was completed in late 1972, and the first test was scheduled for February 1973.

  18. Mobile Energy Laboratory energy-efficiency testing programs

    SciTech Connect

    Parker, G B; Currie, J W

    1992-03-01

    This report summarizes energy-efficiency testing activities applying the Mobile Energy Laboratory (MEL) testing capabilities during the third and fourth quarters of fiscal year (FY) 1991. The MELs, developed by the US Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) and the Naval Energy and Environmental Support Activity (NEESA) for energy testing and energy conservation program support functions at federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in Section 8 of the MEL Use Plan (PNL-6861) for semi-annual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semi-annually to establish priorities for energy-efficient testing applications using the MEL capabilities. The MEL Use Committee is composed of one representative each of the US Department of Energy, US Army, US Air Force, US Navy, and other federal agencies.

  19. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Approval of laboratories to run... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and university laboratories, or in the case of genotype tests, private laboratories will be approved by the Administrator when...

  20. The LINC-NIRVANA fringe and flexure tracker: laboratory tests

    NASA Astrophysics Data System (ADS)

    Tremou, Evangelia; Eckart, Andreas; Horrobin, Matthew; Lindhorst, Bettina; Moser, Lydia; Rost, Steffen; Smajic, Semir; Straubmeier, Christian; Wank, Imke; Zuther, Jens; Bertram, Thomas

    2010-07-01

    LINC-NIRVANA is the NIR homothetic imaging camera for the Large Binocular Telescope (LBT). In close cooperation with the Adaptive Optics systems of LINC-NIRVANA the Fringe and Flexure Tracking System (FFTS) is a fundamental component to ensure a complete and time-stable wavefront correction at the position of the science detector in order to allow for long integration times at interferometric angular resolutions. In this contribution, we present the design and the realization of the ongoing FFTS laboratory tests, taking into account the system requirements. We have to sample the large Field of View and to follow the reference source during science observations to an accuracy of less than 2 microns. In particular, important tests such as cooling tests of cryogenic components and tip - tilt test (the repeatability and the precision under the different inclinations) are presented. The system parameters such as internal flexure and precision are discussed.

  1. Recommendations for Lipid Testing and Reporting by Australian Pathology Laboratories

    PubMed Central

    Appleton, Charles A; Caldwell, Grahame; McNeil, Alan; Meerkin, Matthew; Sikaris, Ken; Sullivan, David R; Thomas, David W; Tognarini, David P

    2007-01-01

    The importance of measuring blood lipids in determining the absolute risk of a cardiovascular event is now well established. In Australia, the National Heart Foundation of Australia and the Cardiac Society of Asutralia and New Zealand (NHFA/CSANZ) have done much to educate doctors. In recent years the recommendations of the NHFA/CSANZ have been based on values for Low-density lipoprotein (LDL-C) as well as High-density lipoprotein cholesterol (HDL-C) and Triglyceride (TG). This change has been reflected in requests to pathology laboratories. However the interpretation of these results may be difficult and the NHFA guidelines outline desirable values for patients at high risk only. There are no formal recommendations for reference intervals or interpretive comments. With the availability of expert systems, some pathology laboratories are now in a better position to provide specific comments to assist with the interpretation of test results. An ad hoc committee of private and public chemical pathologists met to draft recommendations for lipid testing and reporting by Australian pathology providers, on the basis of current guidelines and their own expertise. Provisions in the current Medicare Benefits Schedule (MBS) for lipid testing were reviewed, and the indications for lipid testing, recommended tests, the logistics of managing specimens, methods of analysis and availability of specialised tests have been documented. Recommendations are made on the provision of desirable values for lipid tests. Suggestions are provided on interpretive comments which could accompany reports of lipid test results, including categorisation of the likely associated lipoprotein abnormalities, their causes, contribution to risk for cardiovascular disease (CVD) and targets for treatment. Current and future approaches to the assessment of risk for CVD are discussed. PMID:17687413

  2. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and university laboratories, or in the case of genotype tests, private laboratories will be approved by the Administrator when...

  3. Radiometric & other requirements for accreditation of PV testing laboratories

    SciTech Connect

    Zerlaut, G.A.

    1995-09-01

    It is intended that the requirements for calibration, traceability of calibration and statistical representation of calibration and test data represent additional requirement of the Laboratory Quality System developed in support of the photovoltaic module certification and labeling program. The elements of this program, which are listed in Chart 1 in the form of major program documentation, have been developed in a contract at Arizona State University under Subcontract from NREL. Documents PV-1 through PV-2, as well as technical issues and deliberations of the Criteria Development Committee (CDC), represent the Phase I results are presented in NREL Report TP-412-7680. Phase II of the program is currently underway and certain of the results of this work are the subject of this paper. Much of the material presented in this paper were developed by the author as Document PV-1. 1a. (Addendum to Document PV-1), which is currently out for review by the CDC. These requirements are intended to be employed by laboratories engaged in testing photovoltaic devices in support of the module certification program, and assessment bodies, and their assessors (or auditors), as additional criteria against which laboratories are examined for the purposes of initial and continuing accreditation.

  4. Evidence-based laboratory medicine - a guide for critical evaluation of in vitro laboratory testing.

    PubMed

    Christenson, Robert H

    2007-03-01

    Evidence-based laboratory medicine (EBLM) is an essential part of modern laboratory medicine practice. This review presents a guide for better understanding and implementing the EBLM process. The process of EBLM begins with development of a clinically relevant question. Tools for assisting in question formulation include the Patient Intervention Comparator and Outcome (PICO) or Case Assay Predicate and Outcome (CAPO) strategies. Locating evidence that addresses the question is performed using resources available on the internet. Systematic reviews that have objectively collated evidence addressing the question can be particularly useful. The evidence collected must be critically appraised using checklists developed for this purpose. Diagnostic performance of tests is frequently stated in terms of sensitivity, specificity, negative and positive predictive values, and the diagnostic odds ratio. Evaluating 95% confidence limits is important for interpretation. Likelihood ratios for tests in disease states are also important for converting pre-test probabilities to post-test probabilities using Bayes Theorem. Tools such as Receiver Operator Characteristic curves and Fagan's diagram are important analytical and visual aids. Laboratorians must give thoughtful consideration into conveying information to clinicians in a useful format. Evidence-based guidelines and collaboration with clinicians are important for development of local care paths. Auditing the effectiveness of implemented care paths is an important part of quality management. In conclusion, effective use of EBLM can benefit patients by helping laboratorians provide the best-available information in the clinically relevant time frame. Presenting the information appropriately maximizes clinical application of the best evidence.

  5. The Role of Laboratory Tests in Crohn’s Disease

    PubMed Central

    Cappello, Maria; Morreale, Gaetano Cristian

    2016-01-01

    In the past, laboratory tests were considered of limited value in Crohn’s disease (CD). In the era of biologics, laboratory tests have become essential to evaluate the inflammatory burden of the disease (C-reactive protein, fecal calprotectin) since symptoms-based scores are subjective, to predict the response to pharmacological options and the risk of relapse, to discriminate CD from ulcerative colitis, to select candidates to anti-tumor necrosis factors [screening tests looking for hepatitis B virus and hepatitis C virus status and latent tuberculosis], to assess the risk of adverse events (testing for thiopurine metabolites and thiopurine-methyltransferase activity), and to personalize and optimize therapy (therapeutic drug monitoring). Pharmacogenetics, though presently confined to the assessment of thiopurineme methyltransferase polymorphisms and hematological toxicity associated with thiopurine treatment, is a promising field that will contribute to a better understanding of the molecular mechanisms of the variability in response to the drugs used in CD with the attempt to expand personalized care and precision medicine strategies. PMID:27656094

  6. The Role of Laboratory Tests in Crohn's Disease.

    PubMed

    Cappello, Maria; Morreale, Gaetano Cristian

    2016-01-01

    In the past, laboratory tests were considered of limited value in Crohn's disease (CD). In the era of biologics, laboratory tests have become essential to evaluate the inflammatory burden of the disease (C-reactive protein, fecal calprotectin) since symptoms-based scores are subjective, to predict the response to pharmacological options and the risk of relapse, to discriminate CD from ulcerative colitis, to select candidates to anti-tumor necrosis factors [screening tests looking for hepatitis B virus and hepatitis C virus status and latent tuberculosis], to assess the risk of adverse events (testing for thiopurine metabolites and thiopurine-methyltransferase activity), and to personalize and optimize therapy (therapeutic drug monitoring). Pharmacogenetics, though presently confined to the assessment of thiopurineme methyltransferase polymorphisms and hematological toxicity associated with thiopurine treatment, is a promising field that will contribute to a better understanding of the molecular mechanisms of the variability in response to the drugs used in CD with the attempt to expand personalized care and precision medicine strategies.

  7. Technical baseline description for in situ vitrification laboratory test equipment

    SciTech Connect

    Beard, K.V.; Bonnenberg, R.W.; Watson, L.R.

    1991-09-01

    IN situ vitrification (ISV) has been identified as possible waste treatment technology. ISV was developed by Pacific Northwest Laboratory (PNL), Richland, Washington, as a thermal treatment process to treat contaminated soils in place. The process, which electrically melts and dissolves soils and associated inorganic materials, simultaneously destroys and/or removes organic contaminants while incorporating inorganic contaminants into a stable, glass-like residual product. This Technical Baseline Description has been prepared to provide high level descriptions of the design of the Laboratory Test model, including all design modifications and safety improvements made to data. Furthermore, the Technical Baseline Description provides a basic overview of the interface documents for configuration management, program management interfaces, safety, quality, and security requirements. 8 figs.

  8. Laboratory testing for cobalamin deficiency in megaloblastic anemia.

    PubMed

    Oberley, Matthew J; Yang, David T

    2013-06-01

    Cobalamin (vitamin B12) deficiency is a common cause of megaloblastic anemia in Western populations. Laboratory evaluation of megaloblastic anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in the clinical laboratory with competitive binding luminescence assays, whose results may not always accurately reflect actual cobalamin stores. Surrogate markers of cobalamin deficiency such as methylmalonic acid and homocysteine have been utilized to improve diagnostic accuracy; however, the specificity of these tests by themselves is rather low. Measurement of the biologically active fraction of cobalamin, holotranscobalamin, has been proposed as a replacement for current total cobalamin assays. Although holotranscobalamin measurements appear to have slighter better sensitivity, the specificity of this assay remains to be determined. The relative merits and demerits of commonly available methods to assess cobalamin deficiency in patients with suspected megaloblastic anemia are discussed. Copyright © 2013 Wiley Periodicals, Inc.

  9. Are Guidelines Guiding us on How to Utilize Laboratory Tests?

    PubMed Central

    2015-01-01

    Increasing patient risks and costs associated with the delivery of health care services have been related to inappropriate and uncontrolled use of biomarkers which make evidence-based guideline recommendations for best practice increasingly important. The translation of basic scientific discoveries into clinically meaningful studies and then to evidence-based clinical practice guidelines (CPGs) or health policy is, however, not straightforward. CPGs are potentially the most influential publications as they aim to guide clinical decisions and impact patient outcomes; hence, current approaches to their development often fail scientific publication standards. Critical appraisal of CPGs has revealed that many do not involve laboratory professionals in formulating recommendations on the use of tests; the composition of the panel could influence the scope of guidelines and over-represent certain stakeholders’ views; numerous CPGs do not have rigorous evidence-based methodology and miss essential information important for the correct interpretation and application of laboratory results. PMID:27683490

  10. Most clinical laboratory testing in Kampala occurs in high-volume, high-quality laboratories or low-volume, low-quality laboratories. A tale of two cities.

    PubMed

    Amukele, Timothy K; Schroeder, Lee F; Jackson, J Brooks; Elbireer, Ali

    2015-01-01

    To describe key characteristics (laboratory quality, test volumes, and complexity) of clinical laboratories in Kampala, Uganda (population ~1.7 million). Cross-sectional survey using a standard questionnaire to document laboratory type and quality, as well as test menus and volumes. Quality was based on the World Health Organization-Africa Region checklist. Of the 954 laboratories identified (a density of one laboratory per 1,781 persons), 779 (82%) performed only simple kit tests or light microscope examinations. The 95% (907/954) of laboratories for whom volumes were obtained performed an average aggregate of 13,189 tests daily, for a test utilization rate of around 2 tests per individual per year. Laboratories could be segregated into eight groups based on quality, test volume, and complexity. However, 90% of the testing was performed by just two groups: (1) low-volume (≤100 tests daily), low-quality laboratories performing simple tests or (2) high-volume (>100 tests daily), high-quality laboratories. Each of these two groups did 45% of the daily testing volume (90% combined). Clinical laboratory density in Kampala (1/1,781 persons) is high, approaching that in the United States (1/1,347 persons). Low-volume/low-quality and high-volume/high-quality laboratories do 90% of the daily aggregate testing. Quality improvement (QI) schemes for Africa must be appropriate to low-volume laboratories as well as to the large laboratories that have been the focus of previous QI efforts. Copyright© by the American Society for Clinical Pathology.

  11. CERTS Microgrid Laboratory Test Bed - PIER Final Project Report

    SciTech Connect

    Eto, Joseph H.; Eto, Joseph H.; Lasseter, Robert; Schenkman, Ben; Klapp, Dave; Linton, Ed; Hurtado, Hector; Roy, Jean; Lewis, Nancy Jo; Stevens, John; Volkommer, Harry

    2008-07-25

    The objective of the CERTS Microgrid Laboratory Test Bed project was to enhance the ease of integrating small energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of small generating sources. The techniques comprising the CERTS Microgrid concept are: 1) a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation; 2) an approach to electrical protection within the microgrid that does not depend on high fault currents; and 3) a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications. The techniques were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations, and finally through factory acceptance testing of individual microgrid components. The islanding and resychronization method met all Institute of Electrical and Electronics Engineers 1547 and power quality requirements. The electrical protections system was able to distinguish between normal and faulted operation. The controls were found to be robust and under all conditions, including difficult motor starts. The results from these test are expected to lead to additional testing of enhancements to the basic techniques at the test bed to improve the business case for microgrid technologies, as well to field demonstrations involving microgrids that involve one or mroe of the CERTS Microgrid concepts.

  12. Occupant Kinematics in Laboratory Rollover Tests: PMHS Response.

    PubMed

    Lessley, David J; Riley, Patrick; Zhang, Qi; Foltz, Patrick; Overby, Brian; Heltzel, Sara; Sochor, Mark; Crandall, Jeff; Kerrigan, Jason R

    2014-11-01

    The objective of the current study was to characterize the whole-body kinematic response of restrained PMHS in controlled laboratory rollover tests. A dynamic rollover test system (DRoTS) and a parametric vehicle buck were used to conduct 36 rollover tests on four adult male PMHS with varied test conditions to study occupant kinematics during the rollover event. The DRoTS was used to drop/catch and rotate the test buck, which replicated the occupant compartment of a typical mid-sized SUV, around its center of gravity without roof-to-ground contact. The studied test conditions included a quasi-static inversion (4 tests), an inverted drop and catch that produced a 3 g vertical deceleration (4 tests), a pure dynamic roll at 360 degrees/second (11 tests), and a roll with a superimposed drop and catch produced vertical deceleration (17 tests). Each PMHS was restrained with a three-point belt and was tested in both leading-side and trailing-side front-row seating positions. Whole-body kinematics were measured using a 3D motion capture system that quantified occupant displacement relative to the vehicle buck for the X-axis (longitudinal), Y-axis (lateral), and Z-axis (vertical) directions. Additionally the spine was divided into five segments to describe intrasegmental kinematics of the spine, including segment rotations as well as spinal extension and compression. The reported data represent the most complete set of kinematic response targets for a restrained occupant in a variety of dynamic rollover conditions, and are immediately useful for efforts to evaluate and improve existing ATDs and computational models for use in the rollover crash environment.

  13. How to test NISP instrument for EUCLID mission in laboratory

    NASA Astrophysics Data System (ADS)

    Costille, A.; Carle, Michael; Fabron, Christophe; Prieto, Eric; Beaumont, Florent; Jessen, Niels-Christian; Jakobsen, Peter; Sørensen, Anton N.; Andersen, Michael I.; Grupp, Frank; Maciaszek, Thierry; Ealet, Anne; Gillard, William; Clemens, Jean-Claude

    2016-07-01

    The ESA mission Euclid is designed to explore the dark side of the Universe. The NISP (Near Infrared Spectro- Photometer) is one of its two instruments operating in the near-IR spectral region (0.9-2μm), that will be fully integrated and tested at Laboratory d'Astrophysique de Marseille (LAM) under vacuum and thermal conditions. The test campaign will regroup functional tests, performance tests, calibration procedure validation and observations scenario test. One of the main objectives of the test campaign will be the measurement of the focus position of NISP with respect to the EUCLID object plane. To achieve these tests campaign, a global Ground Support Equipment (GSE) called the Verification Ground System (VGS) has to be developed. It will be a complex set of GSE integrated in ERIOS chamber made of: a telescope simulator to simulate the EUCLID telescope and to inject light into NISP, a thermal environment to be used for NISP thermal balance and verification, a sets of mechanical interfaces to align all the parts into ERIOS chamber, the NISP Electrical GSE (EGSE) to control the instrument during the test and a metrology system to measure the positions of the components during the test. We will present the preliminary design and concepts of the VGS and we will show the main difficulties we have to deal with: design of thermal environment at 80K with 4mK stability, the development of a metrology system in vacuum, knowledge of the focus position within 150μm in cold, etc. The main objectives of the NISP test will be explained and how the VGS responds to the test requirement.

  14. Laboratory Performance Testing of Residential Window Air Conditioners

    SciTech Connect

    Winkler, J.; Booten, C.; Christensen, D.; Tomerlin, J.

    2013-03-01

    Window air conditioners are the dominant cooling product for residences, in terms of annual unit sales. They are inexpensive, portable and can be installed by the owner. For this reason, they are an attractive solution for supplemental cooling, for retrofitting air conditioning into a home which lacks ductwork, and for renters. Window air conditioners for sale in the United States are required to meet very modest minimum efficiency standards. Four window air conditioners' performance were tested in the Advanced HVAC Systems Laboratory on NREL's campus in Golden, CO. In order to separate and study the refrigerant system's performance, the unit's internal leakage pathways, the unit's fanforced ventilation, and the leakage around the unit resulting from installation in a window, a series of tests were devised that focused on each aspect of the unit's performance. These tests were designed to develop a detailed performance map to determine whole-house performance in different climates. Even though the test regimen deviated thoroughly from the industry-standard ratings test, the results permit simple calculation of an estimated rating for both capacity and efficiency that would result from a standard ratings test. Using this calculation method, it was found that the three new air conditioners' measured performance was consistent with their ratings. This method also permits calculation of equivalent SEER for the test articles. Performance datasets were developed across a broad range of indoor and outdoor operating conditions, and used them to generate performance maps.

  15. Digital Audio Radio Broadcast Systems Laboratory Testing Nearly Complete

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Radio history continues to be made at the NASA Lewis Research Center with the completion of phase one of the digital audio radio (DAR) testing conducted by the Consumer Electronics Group of the Electronic Industries Association. This satellite, satellite/terrestrial, and terrestrial digital technology will open up new audio broadcasting opportunities both domestically and worldwide. It will significantly improve the current quality of amplitude-modulated/frequency-modulated (AM/FM) radio with a new digitally modulated radio signal and will introduce true compact-disc-quality (CD-quality) sound for the first time. Lewis is hosting the laboratory testing of seven proposed digital audio radio systems and modes. Two of the proposed systems operate in two modes each, making a total of nine systems being tested. The nine systems are divided into the following types of transmission: in-band on-channel (IBOC), in-band adjacent-channel (IBAC), and new bands. The laboratory testing was conducted by the Consumer Electronics Group of the Electronic Industries Association. Subjective assessments of the audio recordings for each of the nine systems was conducted by the Communications Research Center in Ottawa, Canada, under contract to the Electronic Industries Association. The Communications Research Center has the only CCIR-qualified (Consultative Committee for International Radio) audio testing facility in North America. The main goals of the U.S. testing process are to (1) provide technical data to the Federal Communication Commission (FCC) so that it can establish a standard for digital audio receivers and transmitters and (2) provide the receiver and transmitter industries with the proper standards upon which to build their equipment. In addition, the data will be forwarded to the International Telecommunications Union to help in the establishment of international standards for digital audio receivers and transmitters, thus allowing U.S. manufacturers to compete in the

  16. When laboratory tests can mislead even when they appear plausible.

    PubMed

    Ismail, Adel Aa

    2017-07-01

    A laboratory test has three phases, pre-analytical, analytical and post-analytical. The purpose of this review is to highlight an issue concerning the analytical phase of one of the most widely deployed groups of in vitro diagnostic tests using a common technology - namely immunoassay.Immunoassay entails an inherently high error rate and, therefore, has the potential for inaccurate and misleading results susceptible to misinterpretation and/or diagnostic misapplication by clinicians. An approach based on Bayesian inference (without mathematics or equations) - illustrated by examples - is presented; this may help clinicians in discerning potentially erroneous results even when they appear plausible and not unreasonable.Essentially, false positive results are most likely to occur when the disease prevalence/incidence is low. False negative results become more prominent when the prevalence/incidence of disease increases. When concern is raised, available follow-up laboratory tests should be initiated to establish with confidence the diagnostic reliability or unreliability of such results. © Royal College of Physicians 2017. All rights reserved.

  17. Retrofitting Combined Space and Water Heating Systems. Laboratory Tests

    SciTech Connect

    Schoenbauer, B.; Bohac, D.; Huelman, P.; Olsen, R.; Hewett, M.

    2012-10-01

    Better insulated and tighter homes can often use a single heating plant for both space and domestic water heating. These systems, called dual integrated appliances (DIA) or combination systems, can operate at high efficiency and eliminate combustion safety issues associated by using a condensing, sealed combustion heating plant. Funds were received to install 400 DIAs in Minnesota low-income homes. The NorthernSTAR DIA laboratory was created to identify proper system components, designs, operating parameters, and installation procedures to assure high efficiency of field installed systems. Tests verified that heating loads up to 57,000 Btu/hr can be achieved with acceptable return water temperatures and supply air temperatures.

  18. Retrofitting Combined Space and Water Heating Systems: Laboratory Tests

    SciTech Connect

    Schoenbauer, B.; Bohac, D.; Huelman, P.; Olson, R.; Hewitt, M.

    2012-10-01

    Better insulated and tighter homes can often use a single heating plant for both space and domestic water heating. These systems, called dual integrated appliances (DIA) or combination systems, can operate at high efficiency and eliminate combustion safety issues associated by using a condensing, sealed combustion heating plant. Funds were received to install 400 DIAs in Minnesota low-income homes. The NorthernSTAR DIA laboratory was created to identify proper system components, designs, operating parameters, and installation procedures to assure high efficiency of field installed systems. Tests verified that heating loads up to 57,000 Btu/hr can be achieved with acceptable return water temperatures and supply air temperatures.

  19. Clinical and Laboratory Testing for Trichomonas vaginalis Infection

    PubMed Central

    2015-01-01

    Trichomonas vaginalis infection is highly prevalent in the United States and worldwide. Traditional clinical diagnostic methods fail to identify more than half of these infections that, if left untreated, can result in adverse pregnancy outcomes and an exacerbated risk of both acquisition and transmission of HIV. Women bear a disproportionate amount of the burden of these infections, and testing among populations at risk for this disease should be provided. Molecular technologies have expanded our capacity for laboratory-based detection of infection and can be used on samples already being collected for chlamydia/gonorrhea screening. PMID:26491181

  20. Prototype dish testing and analysis at Sandia National Laboratories

    NASA Astrophysics Data System (ADS)

    Grossman, J. W.; Houser, R. M.; Erdman, W. W.

    1991-12-01

    During the past year, Sandia National Laboratories performed on-sun testing of several dish concentrator concepts. These tests were undertaken at the National Solar Thermal Test Facility (NSTTF). Two of the tests were performed in support of the DOE Concentrator Receiver Development Program. The first was on-sun testing of the single-element stretched-membrane dish; this 7-meter diameter dish uses a single preformed metal membrane with an aluminized polyester optical surface and shows potential for future dish-Stirling systems. The next involved two prototype facets from the Faceted Stretched-Membrane Dish Program. These facets, representing competitive design concepts, are closest to commercialization. Five 1-meter triangular facets were tested on-sun as part of the development program for a solar dynamic system on Space Station Freedom. While unique in character, all the tests utilized the Beam Characterization System (BCS) as the main measurement tool and all were analyzed using the Sandia-developed CIRCE2 computer code. The BCS is used to capture and digitize an image of the reflected concentrator beam that is incident on a target surface. The CIRCE2 program provides a computational tool, which when given the geometry of the concentrator and target as well as other design parameters will predict the flux distribution of the reflected beam. One of these parameters, slope error, is the variable that has a major effect in determining the quality of the reflected beam. The methodology used to combine these two tools to predict uniform slope errors for the dishes is discussed in this document. As the Concentrator Development Programs continue, Sandia will test and evaluate two prototype dish systems. The first, the faceted stretched-membrane dish, is expected to be tested in 1992, followed by the full-scale single-element stretched-membrane dish in 1993. These tests will use the tools and methodology discussed in this document.

  1. 42 CFR 493.1459 - Condition: Laboratories performing high complexity testing; general supervisor.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1459 Condition: Laboratories performing high complexity testing; general supervisor. The laboratory must have one...

  2. 42 CFR 493.1447 - Condition: Laboratories performing high complexity testing; technical supervisor.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1447 Condition: Laboratories performing high complexity testing; technical supervisor. The laboratory must have a...

  3. Feasibility study of an orbiting laboratory for testing CSI technology

    NASA Technical Reports Server (NTRS)

    Bicos, Andrew S.; Loboda, Gregory G.

    1993-01-01

    A concept for an orbiting laboratory for testing Controls-Structures Integration (CSI) technology is described. The CSI-Star concept reflects a lower cost, higher risk approach. The concept supports demonstration and validation testing for critical CSI technologies at a cost of $20M to $26M with a 1-year reliability of approximately 0.9. The Ball Aerospace QuickStar bus is the carrier for the CSI test article. QuickStar is launched as a secondary payload on the McDonnell Douglas Delta 2. The QuickStar/Delta 2 approach is flight proven. The CSI test article is a 20 foot, 1 Hz, truss beam which is deployed from the QuickStar bus. The test article is well instrumented for quality system identification. The laboratory provides three layers of active control consisting of global vibration suppression along the truss beam, vibration isolation between the beam and instrument platforms, and vibration compensation through the use of gimbaled platforms which point lasers relative to optical sensor targets. The configuration simulates the dynamics of multi-instrument science platforms such as those of the Earth Observation System (EOS) while maintaining strong ties to astrophysics missions such as the Optical Interferometer. Uplink/downlink services and a reprogrammable computer provide flexibility for long-term investigations by members of the CSI community (NASA, DoD, academia, and industry). CSI-Star fills the gap between short-term experiments, which have been conducted primarily on the Shuttle, and future science missions which require the technology. The on-orbit maturity of CSI technology must be established to obtain acceptance by project managers and to promote injection of the technology into future science missions.

  4. Laboratory test data on the stability of the STIS MAMAs

    NASA Technical Reports Server (NTRS)

    Joseph, Charles L.

    1997-01-01

    STIS has two MAMA detectors systems with distinctly different tube configurations. The first (designated BAND 1) has an opaque CsI photocathode deposited on the microchannel plate (MCP) providing wavelength coverage from 1150A to 1700A. The other MAMA (designated BAND 2) has a semitransparent CS2Te photocathode deposited on the faceplate in close proximity to the input of the MCP. It covers the 1650A to 3100A bandpass and serves as a backup for the short wavelength detector. Laboratory test data indicate that both of these detectors have good sensitivity, have good uniformity and provide stable response, making each capable of collecting data with a signal-to-noise ratio in excess of 100 per Space Telescope Imaging Spectrograph (STIS) optical resolution element. Over a multiyear development effort, a substantial body of laboratory test data (more than 6 GBytes spanning more than 6 years of collection) has accumulated on more than a dozen fabricated tubes. These tests even included a few destructive evaluations to examine the limitations and operating life. In addition, analyses where conducted regarding impact caused by the specified electronic tolerances and expected changes in the Hubble Space Telescope (HST) thermal environment. Perhaps the simplest test of stability is to collect a sequence of images, each with a uniform illumination, and use these individual "flat fields" to remove the pixel-to-pixel sensitivity in the other flat fields. These sequences typically spanned 3-5 weeks of time. The detectors are very stable, allowing the pixel-to-pixel sensitivity to be removed with good precision. The STIS specification for stability is 1% (sufficient for data with a S/N = 100) over a 1 week period and 2% over 30 days. All Engineering Model Units as well as Flight Detectors tested exceeded this specification.

  5. Feasibility study of an orbiting laboratory for testing CSI technology

    NASA Astrophysics Data System (ADS)

    Bicos, Andrew S.; Loboda, Gregory G.

    1993-08-01

    A concept for an orbiting laboratory for testing Controls-Structures Integration (CSI) technology is described. The CSI-Star concept reflects a lower cost, higher risk approach. The concept supports demonstration and validation testing for critical CSI technologies at a cost of $20M to $26M with a 1-year reliability of approximately 0.9. The Ball Aerospace QuickStar bus is the carrier for the CSI test article. QuickStar is launched as a secondary payload on the McDonnell Douglas Delta 2. The QuickStar/Delta 2 approach is flight proven. The CSI test article is a 20 foot, 1 Hz, truss beam which is deployed from the QuickStar bus. The test article is well instrumented for quality system identification. The laboratory provides three layers of active control consisting of global vibration suppression along the truss beam, vibration isolation between the beam and instrument platforms, and vibration compensation through the use of gimbaled platforms which point lasers relative to optical sensor targets. The configuration simulates the dynamics of multi-instrument science platforms such as those of the Earth Observation System (EOS) while maintaining strong ties to astrophysics missions such as the Optical Interferometer. Uplink/downlink services and a reprogrammable computer provide flexibility for long-term investigations by members of the CSI community (NASA, DoD, academia, and industry). CSI-Star fills the gap between short-term experiments, which have been conducted primarily on the Shuttle, and future science missions which require the technology. The on-orbit maturity of CSI technology must be established to obtain acceptance by project managers and to promote injection of the technology into future science missions.

  6. Laboratory test data on the stability of the STIS MAMAs

    NASA Technical Reports Server (NTRS)

    Joseph, Charles L.

    1997-01-01

    STIS has two MAMA detectors systems with distinctly different tube configurations. The first (designated BAND 1) has an opaque CsI photocathode deposited on the microchannel plate (MCP) providing wavelength coverage from 1150A to 1700A. The other MAMA (designated BAND 2) has a semitransparent CS2Te photocathode deposited on the faceplate in close proximity to the input of the MCP. It covers the 1650A to 3100A bandpass and serves as a backup for the short wavelength detector. Laboratory test data indicate that both of these detectors have good sensitivity, have good uniformity and provide stable response, making each capable of collecting data with a signal-to-noise ratio in excess of 100 per Space Telescope Imaging Spectrograph (STIS) optical resolution element. Over a multiyear development effort, a substantial body of laboratory test data (more than 6 GBytes spanning more than 6 years of collection) has accumulated on more than a dozen fabricated tubes. These tests even included a few destructive evaluations to examine the limitations and operating life. In addition, analyses where conducted regarding impact caused by the specified electronic tolerances and expected changes in the Hubble Space Telescope (HST) thermal environment. Perhaps the simplest test of stability is to collect a sequence of images, each with a uniform illumination, and use these individual "flat fields" to remove the pixel-to-pixel sensitivity in the other flat fields. These sequences typically spanned 3-5 weeks of time. The detectors are very stable, allowing the pixel-to-pixel sensitivity to be removed with good precision. The STIS specification for stability is 1% (sufficient for data with a S/N = 100) over a 1 week period and 2% over 30 days. All Engineering Model Units as well as Flight Detectors tested exceeded this specification.

  7. TRITIUM LABORATORY, TRA666, INTERIOR. DETAIL OF TEST LOOP PIPING. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TRITIUM LABORATORY, TRA-666, INTERIOR. DETAIL OF TEST LOOP PIPING. INL NEGATIVE NO. HD30-1-3. Mike Crane, Photographer, 6/2001 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  8. 49 CFR 40.89 - What is validity testing, and are laboratories required to conduct it?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.89 What is validity testing, and are laboratories required to conduct it? (a) Specimen validity testing is... 49 Transportation 1 2014-10-01 2014-10-01 false What is validity testing, and are laboratories...

  9. 42 CFR 493.25 - Laboratories performing tests of high complexity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Laboratories performing tests of high complexity....25 Laboratories performing tests of high complexity. (a) A laboratory must obtain a certificate for tests of high complexity if it performs one or more tests that meet the criteria for tests of high...

  10. Laboratory Testing of Waste Isolation Pilot Plant Surrogate Waste Materials

    NASA Astrophysics Data System (ADS)

    Broome, S.; Bronowski, D.; Pfeifle, T.; Herrick, C. G.

    2011-12-01

    The Waste Isolation Pilot Plant (WIPP) is a U.S. Department of Energy geological repository for the permanent disposal of defense-related transuranic (TRU) waste. The waste is emplaced in rooms excavated in the bedded Salado salt formation at a depth of 655 m below the ground surface. After emplacement of the waste, the repository will be sealed and decommissioned. WIPP Performance Assessment modeling of the underground material response requires a full and accurate understanding of coupled mechanical, hydrological, and geochemical processes and how they evolve with time. This study was part of a broader test program focused on room closure, specifically the compaction behavior of waste and the constitutive relations to model this behavior. The goal of this study was to develop an improved waste constitutive model. The model parameters are developed based on a well designed set of test data. The constitutive model will then be used to realistically model evolution of the underground and to better understand the impacts on repository performance. The present study results are focused on laboratory testing of surrogate waste materials. The surrogate wastes correspond to a conservative estimate of the degraded containers and TRU waste materials after the 10,000 year regulatory period. Testing consists of hydrostatic, uniaxial, and triaxial tests performed on surrogate waste recipes that were previously developed by Hansen et al. (1997). These recipes can be divided into materials that simulate 50% and 100% degraded waste by weight. The percent degradation indicates the anticipated amount of iron corrosion, as well as the decomposition of cellulosics, plastics, and rubbers. Axial, lateral, and volumetric strain and axial and lateral stress measurements were made. Two unique testing techniques were developed during the course of the experimental program. The first involves the use of dilatometry to measure sample volumetric strain under a hydrostatic condition. Bulk

  11. CONTROL TESTING OF THE UK NATIONAL NUCLEAR LABORATORY'S RADBALL TECHNOLOGY AT SAVANNAH RIVER NATIONAL LABORATORY

    SciTech Connect

    Farfan, E.

    2009-11-23

    The UK National Nuclear Laboratory (NNL) has developed a remote, non-electrical, radiation-mapping device known as RadBall (patent pending), which offers a means to locate and quantify radiation hazards and sources within contaminated areas of the nuclear industry. To date, the RadBall has been deployed in a number of technology trials in nuclear waste reprocessing plants at Sellafield in the UK. The trials have demonstrated the successful ability of the RadBall technology to be deployed and retrieved from active areas. The positive results from these initial deployment trials and the anticipated future potential of RadBall have led to the NNL partnering with the Savannah River National Laboratory (SRNL) to further underpin and strengthen the technical performance of the technology. RadBall consists of a colander-like outer shell that houses a radiation-sensitive polymer sphere. It has no power requirements and can be positioned in tight or hard-to reach places. The outer shell works to collimate radiation sources and those areas of the polymer sphere that are exposed react, becoming increasingly less transparent, in proportion to the absorbed dose. The polymer sphere is imaged in an optical-CT scanner which produces a high resolution 3D map of optical attenuation coefficients. Subsequent analysis of the optical attenuation maps provides information on the spatial distribution and strength of the sources in a given area forming a 3D characterization of the area of interest. This study completed at SRNL addresses key aspects of the testing of the RadBall technology. The first set of tests was performed at Savannah River Nuclear Solutions Health Physics Instrument Calibration Laboratory (HPICL) using various gamma-ray sources and an x-ray machine with known radiological characteristics. The objective of these preliminary tests was to identify the optimal dose and collimator thickness. The second set of tests involved a highly contaminated hot cell. The objective of

  12. DNA testing of sexual assault evidence: the laboratory perspective.

    PubMed

    Burg, Abby; Kahn, Roger; Welch, Katherine

    2011-09-01

    The availability of DNA testing has dramatically changed the way that crimes are investigated. DNA results can link offenders to their crimes, exonerate wrongfully accused individuals, identify mass fatality victims and more. In the case of sexual assault, DNA evidence alone cannot prove that a sexual assault has occurred. DNA analysis can only reveal whether a person's DNA is, or is not, present. In this paper, the authors provide readers with an overview of the advantages and limitations of DNA analysis, the importance of proper evidence collection, the technologies available, and the amount of sample needed for testing. Through proper evidence collection and quality laboratory services, the full value of DNA will be realized.

  13. The laboratory station for tyres grip testing on different surfaces

    NASA Astrophysics Data System (ADS)

    Kalinowski, K.; Grabowik, C.; Janik, W.; Ćwikła, G.; Skowera, M.

    2015-11-01

    The paper presents the conception of the device for tyre grip testing in the laboratory conditions. The main purpose is to provide a device working in confined spaces, which enables rapid changes of the tested samples of the road surfaces. Among the key assumptions the minimization of the device dimensions and the relative ease of transportation and mobility - the ability to quick assemble and disassemble were also assumed. The main components of the projected workstation includes: the replaceable platform for mounting samples of a road surface, the roller conveyor, the drive of the platform, the wheel mounting assembly and the axial force measuring system. At the design the station a morphological structure method has been used, particular elements have been optimized individually.

  14. Genetic counselor review of genetic test orders in a reference laboratory reduces unnecessary testing.

    PubMed

    Miller, Christine E; Krautscheid, Patti; Baldwin, Erin E; Tvrdik, Tatiana; Openshaw, Amanda S; Hart, Kim; Lagrave, Danielle

    2014-05-01

    Genetic tests are routinely ordered by health care providers (HCPs) within a wide range of medical specialties. Many providers have limited knowledge or experience with ordering and interpreting genetic tests; thus, test order errors are common. Rigorous review of genetic test orders by genetic counselors (GCs) can provide a direct financial benefit to medical institutions, patients and insurers. GCs at ARUP (Associated Regional University Pathologists) Laboratories routinely perform a preanalytic assessment of complex molecular genetic test orders that includes reviewing clinical and family history information and considering the clinical utility and cost-effectiveness of ordered tests. GCs contact the ordering institution and/or HCP as needed to collect additional clinical information and confirm the test order or suggest alternative testing based on the provided information. A retrospective review of the GC-facilitated test changes over a 21-month period at ARUP laboratories was performed. Approximately 26% of all requests for complex genetic tests assessing germ line mutations were changed following GC review. Testing fees associated with canceled tests were summed to estimate the cost-savings resulting from GC-facilitated test reviews. The test review process resulted in an average reduction in charges to the referring institutions of $48,000.00 per month. GC review of genetic test orders for appropriateness and clinical utility reduces healthcare costs to hospitals, insurers, and patients. © 2014 Wiley Periodicals, Inc.

  15. Bill Kerslake Preparing a Test in the Rocket Laboratory

    NASA Image and Video Library

    1952-10-21

    William Kerslake, a combustion researcher at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory, examines the setup of a transparent rocket in a Rocket Laboratory test cell. Kerslake joined NACA Lewis the previous summer after graduating from the Case Institute of Technology with a chemistry degree. His earliest professional research concentrated on combustion instability in small rocket engines. While at Case the quiet, 250-pound Kerslake also demonstrated his athletic prowess on the wrestling team. He continued wrestling for roughly a decade afterwards while conducting his research with the NACA. Kerslake participated in Olympic competitions in Helsinki (1952), Melbourne (1956), and Rome (1960). He won 30 national championships in three different weight classes and captured the gold at the 1955 Pan American Games in Mexico City. Kerslake accomplished all this while maintaining his research career, raising a family, and paying his own expenses. As his wrestling career was winding down in the early 1960s, Kerslake’s professional career changed, as well. He was transferred to Harold Kaufman’s Electrostatic Propulsion Systems Section in the new Electromagnetic Propulsion Division. Kaufman was developing the first successful ion engine at the time, and Kerslake spent the remainder of his career working in the electric propulsion field. He was heavily involved in the two Space Electric Rocket Test (SERT) missions which demonstrated that the ion thrusters could successfully operate in space. Kerslake retired in 1985 with over 30 years of service.

  16. SPHINX Satellite Testing in the Electric Propulsion Laboratory

    NASA Image and Video Library

    1973-12-21

    Researchers examine the Space Plasma-High Voltage Interaction Experiment (SPHINX) satellite in the Electric Propulsion Laboratory at the National Aeronautics and Space Administration (NASA) Lewis Research Center. Lewis’ Spacecraft Technology Division designed SPHINX to study the electrical interaction of its experimental surfaces with space plasma. They sought to determine if higher orbits would improve the transmission quality of communications satellites. Robert Lovell, the Project Manager, oversaw vibrational and plasma simulation testing of the satellite in the Electric Propulsion Laboratory, seen here. SPHINX was an add-on payload for the first Titan/Centaur proof launch in early 1974. Lewis successfully managed the Centaur Program since 1962, but this would be the first Centaur launch with a Titan booster. Since the proof test did not have a scheduled payload, the Lewis-designed SPHINX received a free ride. The February 11, 1974 launch, however, proved to be one of the Launch Vehicle Division’s lowest days. Twelve minutes after the vehicle departed the launch pad, the booster and Centaur separated as designed, but Centaur’s two RL-10 engines failed to ignite. The launch pad safety officer destroyed the vehicle, and SPHINX never made it into orbit. Overall Centaur has an excellent success rate, but the failed SPHINX launch attempt caused deep disappointment across the center.

  17. Laboratory testing of a continuous emissions monitor for hydrochloric acid.

    PubMed

    Dene, Chuck; Pisano, John T; Durbin, Thomas D; Bumiller, Kurt; Crabbe, Keith; Muzio, Lawrence J

    2014-06-01

    Continuous monitoring of exhaust flue gas has become a common practice in power plants in response to Federal Mercury and Air Toxics Standards (MATS) standards. Under the current rules, hydrochloric acid (HCl) is not continuously measured at most plants; however, MATS standards have been proposed for HCl, and tunable diode laser (TDL) absorption spectroscopy is one method that can be used to measure HCl continuously. The focus of this work is on the evaluation and verification of the operation performance of an HCL TDL over a range of real-world operating environments. The testing was conducted at the University of California at Riverside (UCR) spectroscopy evaluation laboratory. Laboratory tests were conducted at three separate temperatures, 25 degrees C, 100 degrees C, and 200 degrees C, and two distinct moisture levels for the enhanced temperatures, 0%, (2 tests) and 4%, over a concentration range from 0 ppmv to 25 ppmv-m at each of the elevated temperatures. The results showed good instrument accuracy as afunction of changing temperature and moisture. Data analysis showed that the average percentage difference between the ammonia concentration and the calibration source was 3.33% for varying moisture from 0% to 4% and 2.69%for varying temperature from 25 to 100/200 degrees C. An HCl absorption line of 1.742 microm was selected for by the manufacturer for this instrument. The Hi Tran database indicated that CO2 is probably the only major interferent, although the CO2 absorption is very weak at that wavelength. Interference tests for NO, CO, SO2, NH3, and CO2 for a range of concentrations typical of flue gasses in coal-fired power plants did not show any interference with TDL HCl measurements at 1.742 microm. For these interference tests, CO2 was tested at a concentration of 11.9% concentration in N2 for these tests. Average precision over the entire range for all 10 tests is 3.12%. The focus of this study was.an evaluation of the operation performance of a

  18. Laboratory and field testing of improved geothermal rock bits

    SciTech Connect

    Hendrickson, R.R.; Jones, A.H.; Winzenried, R.W.; Maish, A.B.

    1980-07-01

    The development and testing of 222 mm (8-3/4 inch) unsealed, insert type, medium hard formation, high-temperature bits are described. The new bits were fabricated by substituting improved materials in critical bit components. These materials were selected on bases of their high temperature properties, machinability, and heat treatment response. Program objectives required that both machining and heat treating could be accomplished with existing rock bit production equipment. Two types of experimental bits were subjected to laboratory air drilling tests at 250/sup 0/C (482/sup 0/F) in cast iron. These tests indicated field testing could be conducted without danger to the hole, and that bearing wear would be substantially reduced. Six additional experimental bits, and eight conventional bits were then subjected to air drilling a 240/sup 0/C (464/sup 0/F) in Francisan Graywacke at The Geysers, CA. The materials selected improved roller wear by 200%, friction-pin wear by 150%, and lug wear by 150%. Geysers drilling performances compared directly to conventional bits indicate that in-gage drilling life was increased by 70%. All bits at The Geysers are subjected to reaming out-of-gage hole prior to drilling. Under these conditions the experimental bits showed a 30% increase in usable hole over the conventional bits. These tests demonstrated a potential well cost reduction of 4 to 8%. Savings of 12% are considered possible with drilling procedures optimized for the experimental bits.

  19. Experimental laboratory system to generate high frequency test environments

    SciTech Connect

    Gregory, D.L.; Paez, T.L.

    1991-01-01

    This is an extension of two previous analytical studies to investigate a technique for generating high frequency, high amplitude vibration environments. These environments are created using a device attached to a common vibration exciter that permits multiple metal on metal impacts driving a test surface. These analytical studies predicted that test environments with an energy content exceeding 10 kHz could be achieved using sinusoidal and random shaker excitations. The analysis predicted that chaotic vibrations yielding random like test environments could be generated from sinusoidal inputs. In this study, a much simplified version of the proposed system was fabricated and tested in the laboratory. Experimental measurements demonstrate that even this simplified system, utilizing a single impacting object, can generate environments on the test surface with significant frequency content in excess of 40 kHz. Results for sinusoidal shaker inputs tuned to create chaotic impact response are shown along with the responses due to random vibration shaker inputs. The experiments and results are discussed. 4 refs., 5 figs.

  20. A simple measuring device for laboratory indentation tests on cartilage.

    PubMed

    Koeller, Wolfgang; Kunow, Julius; Ostermeyer, Oliver; Stomberg, Peter; Boos, Carsten; Russlies, Martin

    2008-04-01

    Mechanical testing of articular cartilage and repair tissue enables judgment of their capacity in withstanding mechanical loading. In the past, different methods have been developed requiring a complex technical setup and extensive data analysis. Therefore, the aim of the present project was to build up a simple measuring apparatus for laboratory indentation tests. The device consists of an incremental optical displacement transducer with a sleeve bearing guided plunger and a spherical tip made of polished steel (radius: 0.75 or 1.5 mm), a sensitive load cell and a stiff frame. The indentation force results from the plunger's gravity plus the force of the spring inside the displacement transducer and levels at 0.170 N or 0.765 N. The displacement transducer is fixed to the frame via the load cell that enables one to detect the initial contact of the tip with the tissue. The load cell has a standard uncertainty of 2 mN and the displacement transducer of 1 microm. From indentation-creep tests, a "0.25-s elastic modulus" is calculated. Measurements on thin rubber sheets were carried out to determine the quality of the measuring device. Compression tests on cylinders made of these rubber sheets yielded control data, and a good agreement with the "0.25-s elastic modulus" was found. Indentation tests on cartilage at different sites of sheep femoral condyles yielded a very good repeatability of the measurement results (+/-7.5%).

  1. 76 FR 161 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories...

  2. 78 FR 46996 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories...

  3. SINGLE EVENT EFFECTS TEST FACILITY AT OAK RIDGE NATIONAL LABORATORY

    SciTech Connect

    Riemer, Bernie; Gallmeier, Franz X; Dominik, Laura J

    2015-01-01

    Increasing use of microelectronics of ever diminishing feature size in avionics systems has led to a growing Single Event Effects (SEE) susceptibility arising from the highly ionizing interactions of cosmic rays and solar particles. Single event effects caused by atmospheric radiation have been recognized in recent years as a design issue for avionics equipment and systems. To ensure a system meets all its safety and reliability requirements, SEE induced upsets and potential system failures need to be considered, including testing of the components and systems in a neutron beam. Testing of ICs and systems for use in radiation environments requires the utilization of highly advanced laboratory facilities that can run evaluations on microcircuits for the effects of radiation. This paper provides a background of the atmospheric radiation phenomenon and the resulting single event effects, including single event upset (SEU) and latch up conditions. A study investigating requirements for future single event effect irradiation test facilities and developing options at the Spallation Neutron Source (SNS) is summarized. The relatively new SNS with its 1.0 GeV proton beam, typical operation of 5000 h per year, expertise in spallation neutron sources, user program infrastructure, and decades of useful life ahead is well suited for hosting a world-class SEE test facility in North America. Emphasis was put on testing of large avionics systems while still providing tunable high flux irradiation conditions for component tests. Makers of ground-based systems would also be served well by these facilities. Three options are described; the most capable, flexible, and highest-test-capacity option is a new stand-alone target station using about one kW of proton beam power on a gas-cooled tungsten target, with dual test enclosures. Less expensive options are also described.

  4. Informing a realistic laboratory erosion-testing regime--observations.

    PubMed

    Qutieshat, A S; Mason, A G; Chadwick, R G

    2015-11-01

    To measure aspects of fizzy drink consumption in a social environment to inform the development of a laboratory testing regime. This was an observational study in which participants were invited to attend one of four pizza and soft drink parties. All such foods and drinks were served in an air conditioned room at a temperature of 24°C. All drinks were at a temperature of 4°C and each participant was asked to spit out, into graduated cups, their first and second sips. Both the temperature and volume of these were measured. Upon completion of the party the volume of drinks consumed was determined. Video footage of the experiment was recorded for subsequent analysis to determine sip count and the elapsed time period between first and last sip. These values were compared to the analogous measured value of expectorated volume in order to assess the usefulness of video observation in the context of this work. The mean expectorated beverage temperature was 14.9±2.0°C. The mean time spent drinking was 44.2±17.4 minutes with a mean consumption rate of 13.3±6.0 ml/min. Only the sip volume and sip count per can values were significantly different between sexes (P<0.05) with females displaying lower values for volume and a higher sip count. There was close agreement between the sip volume values observed and calculated using video observation derived parameters. Several human drinking behaviour values were reported in this study and these will be of value in the development of more realistic laboratory erosion-testing regimes. It is concluded, within the limitations of this work, that (1) there are differences in the drinking behaviour of males and females with respect to sip volume and count, (2) the intraoral rise in temperature of a 4°C beverage is lower than that used in previous laboratory simulations and (3) the values derived from video observation agree with those measured directly validating this technique for use in further studies. The work provides valuable

  5. Effects of Oritavancin on Coagulation Tests in the Clinical Laboratory.

    PubMed

    Belley, Adam; Robson, Richard; Francis, John L; Adcock, Dorothy M; Tiefenbacher, Stefan; Rubino, Christopher M; Moeck, Greg; Sylvester, David; Dudley, Michael N; Loutit, Jeffery

    2017-02-01

    Previous studies have shown that some lipoglycopeptide and lipopeptide antimicrobial agents may cause falsely elevated values for some phospholipid-dependent coagulation tests. The effect of oritavancin, a lipoglycopeptide antibiotic, on coagulation test results was explored using pooled human plasma samples spiked with drug and in a clinical study after an infusion of a single 1,200-mg intravenous dose of oritavancin in normal healthy volunteers. Pooled plasma with oritavancin added ex vivo showed concentration-dependent prolongation of prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), and dilute Russell viper venom time (DRVVT) test results. In contrast, oritavancin had no effect on the activated protein C resistance assay, chromogenic anti-factor Xa assay (anti-FXa), thrombin time, and an immunoassay for the laboratory diagnosis of heparin-induced thrombocytopenia. In participants that received a single dose of oritavancin, elevations in PT/INR result, aPTT, DRVVT, activated clotting time, and silica clotting time occurred, with the maximum times to resolution of test interference determined to be 12, 120, 72, 24, and 18 h, respectively. The anti-FXa assay was unaffected, whereas transient elevations in D dimer levels were observed in 30% of participants, with a maximum time to resolution of 72 h. Although oritavancin has no impact on the coagulation system in vivo, a single dose of oritavancin can produce falsely elevated values of some coagulation tests used to monitor hemostasis. The interference of oritavancin on affected tests is transient, and the test results revert to normal ranges within specified times after dosing. Copyright © 2017 American Society for Microbiology.

  6. Potential Blood-Based Biomarkers for Concussion

    PubMed Central

    Papa, Linda

    2016-01-01

    Mounting research in the field of sports concussion biomarkers has led to a greater understanding of the effects of brain injury from sports. A recent systematic review of clinical studies examining biomarkers of brain injury following sports-related concussion established that almost all studies have been published either in or after the year 2000. In an effort to prevent CTE and long-term consequences of concussion, early diagnostic and prognostic tools are becoming increasingly important; particularly in sports and in military personnel, where concussions are common occurrences. Early and tailored management of athletes following a concussion with biomarkers could provide them with the best opportunity to avoid further injury. Should blood-based biomarkers for concussion be validated and become widely available, they could have many roles. For instance, a point-of-care test could be used on the field by trained sport medicine professionals to help detect a concussion. In the clinic or hospital setting, it could be used by clinicians to determine the severity of concussion and be used to screen players for neuroimaging (CT and/or MRI) and further neuropsychological testing. Furthermore, biomarkers could have a role in monitoring progression of injury and recovery and in managing patients at high risk of repeated injury by being incorporated into guidelines for return to duty, work or sports activities. There may even be a role for biomarkers as surrogate measures of efficacy in the assessment of new treatments and therapies for concussion. PMID:27482776

  7. Potential Blood-based Biomarkers for Concussion.

    PubMed

    Papa, Linda

    2016-09-01

    Mounting research in the field of sports concussion biomarkers has led to a greater understanding of the effects of brain injury from sports. A recent systematic review of clinical studies examining biomarkers of brain injury following sports-related concussion established that almost all studies have been published either in or after the year 2000. In an effort to prevent chronic traumatic encephalopathy and long-term consequences of concussion, early diagnostic and prognostic tools are becoming increasingly important; particularly in sports and in military personnel, where concussions are common occurrences. Early and tailored management of athletes following a concussion with biomarkers could provide them with the best opportunity to avoid further injury. Should blood-based biomarkers for concussion be validated and become widely available, they could have many roles. For instance, a point-of-care test could be used on the field by trained sport medicine professionals to help detect a concussion. In the clinic or hospital setting, it could be used by clinicians to determine the severity of concussion and be used to screen players for neuroimaging (computed tomography and/or magnetic resonance imaging) and further neuropsychological testing. Furthermore, biomarkers could have a role in monitoring progression of injury and recovery and in managing patients at high risk of repeated injury by being incorporated into guidelines for return to duty, work, or sports activities. There may even be a role for biomarkers as surrogate measures of efficacy in the assessment of new treatments and therapies for concussion.

  8. To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis.

    PubMed

    Dessau, Ram B; van Dam, Alje P; Fingerle, Volker; Gray, Jeremy; Hovius, Joppe; Hunfeld, Klaus-Peter; Jaulhac, Benoit; Kahl, Olaf; Kristoferitsch, Wolfgang; Lindgren, Per-Eric; Markowicz, Mateusz; Mavin, Sally; Ornstein, Katharina; Rupprecht, Tobias; Stanek, Gerold; Strle, Franc

    2017-09-05

    Lyme borreliosis (LB) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. Currently, a large volume of diagnostic testing for Lyme borreliosis is reported, whereas the incidence of clinically relevant disease manifestations is low. This indicates overuse of diagnostic testing for LB with implications for patient care and cost effective health management. The recommendations provided in this review are intended to support both the clinical diagnosis and initiatives for a more rational use of laboratory testing in patients with clinically suspected Lyme borreliosis. This is a narrative review combining various aspects of the clinical and laboratory diagnosis with an educational purpose. The literature search was based on existing systematic reviews, national and international guidelines and supplemented with specific citations. The main recommendations according to current European case definitions for Lyme borreliosis are as follows: Typical erythema migrans should be diagnosed clinically and does not require laboratory testing, the diagnosis of Lyme neuroborreliosis requires laboratory investigation of the spinal fluid including intrathecal antibody production for, and the remaining disease manifestations require testing for antibodies to Borrelia burgdorferi. Testing individuals with non-specific subjective symptoms is not recommended, because of a low positive predictive value. Copyright © 2017. Published by Elsevier Ltd.

  9. Use of the National Committee for Clinical Laboratory Standards Guidelines for Disk Diffusion Susceptibility Testing in New York State Laboratories

    PubMed Central

    Kiehlbauch, Julia A.; Hannett, George E.; Salfinger, Max; Archinal, Wendy; Monserrat, Catherine; Carlyn, Cynthia

    2000-01-01

    Accurate antimicrobial susceptibility testing is vital for patient care and surveillance of emerging antimicrobial resistance. The National Committee for Clinical Laboratory Standards (NCCLS) outlines generally agreed upon guidelines for reliable and reproducible results. In January 1997 we surveyed 320 laboratories participating in the New York State Clinical Evaluation Program for General Bacteriology proficiency testing. Our survey addressed compliance with NCCLS susceptibility testing guidelines for bacterial species designated a problem (Staphylococcus aureus and Enterococcus species) or fastidious (Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae) organism. Specifically, we assessed compliance with guidelines for inoculum preparation, medium choice, number of disks per plate, and incubation conditions for disk diffusion tests. We also included length of incubation for S. aureus and Enterococcus species. We found overall compliance with the five characteristics listed above in 80 of 153 responding laboratories (50.6%) for S. aureus and 72 of 151 (47.7%) laboratories for Enterococcus species. The most common problem was an incubation time shortened to less than 24 h. Overall compliance with the first four characteristics was reported by 92 of 221 (41.6%) laboratories for S. pneumoniae, 49 of 163 (30.1%) laboratories for H. influenzae, and 11 of 77 (14.3%) laboratories for N. gonorrhoeae. Laboratories varied from NCCLS guidelines by placing an excess number of disks per plate. Laboratories also reported using alternative media for Enterococcus species, N. gonorrhoeae, and H. influenzae. This study demonstrates a need for education among clinical laboratories to increase compliance with NCCLS guidelines. PMID:10970381

  10. Current Concepts in Laboratory Testing to Guide Antimicrobial Therapy

    PubMed Central

    Jenkins, Stephen G.; Schuetz, Audrey N.

    2012-01-01

    Antimicrobial susceptibility testing (AST) is indicated for pathogens contributing to an infectious process that warrants antimicrobial therapy if susceptibility to antimicrobials cannot be predicted reliably based on knowledge of their identity. Such tests are most frequently used when the etiologic agents are members of species capable of demonstrating resistance to commonly prescribed antibiotics. Some organisms have predictable susceptibility to antimicrobial agents (ie, Streptococcus pyogenes to penicillin), and empirical therapy for these organisms is typically used. Therefore, AST for such pathogens is seldom required or performed. In addition, AST is valuable in evaluating the activity of new and experimental compounds and investigating the epidemiology of antimicrobial resistant pathogens. Several laboratory methods are available to characterize the in vitro susceptibility of bacteria to antimicrobial agents. When the nature of the infection is unclear and the culture yields mixed growth or usual microbiota (wherein the isolates usually bear little relationship to the actual infectious process), AST is usually unnecessary and results may, in fact, be dangerously misleading. Phenotypic methods for detection of specific antimicrobial resistance mechanisms are increasingly being used to complement AST (ie, inducible clindamycin resistance among several gram-positive bacteria) and to provide clinicians with preliminary direction for antibiotic selection pending results generated from standardized AST (ie, β-lactamase tests). In addition, molecular methods are being developed and incorporated by microbiology laboratories into resistance detection algorithms for rapid, sensitive assessment of carriage states of epidemiologically and clinically important pathogens, often directly from clinical specimens (ie, presence of vancomycin-resistant enterococci in fecal specimens). PMID:22386185

  11. EVA Development and Verification Testing at NASA's Neutral Buoyancy Laboratory

    NASA Technical Reports Server (NTRS)

    Jairala, Juniper C.; Durkin, Robert; Marak, Ralph J.; Sipila, Stepahnie A.; Ney, Zane A.; Parazynski, Scott E.; Thomason, Arthur H.

    2012-01-01

    As an early step in the preparation for future Extravehicular Activities (EVAs), astronauts perform neutral buoyancy testing to develop and verify EVA hardware and operations. Neutral buoyancy demonstrations at NASA Johnson Space Center's Sonny Carter Training Facility to date have primarily evaluated assembly and maintenance tasks associated with several elements of the International Space Station (ISS). With the retirement of the Shuttle, completion of ISS assembly, and introduction of commercial players for human transportation to space, evaluations at the Neutral Buoyancy Laboratory (NBL) will take on a new focus. Test objectives are selected for their criticality, lack of previous testing, or design changes that justify retesting. Assembly tasks investigated are performed using procedures developed by the flight hardware providers and the Mission Operations Directorate (MOD). Orbital Replacement Unit (ORU) maintenance tasks are performed using a more systematic set of procedures, EVA Concept of Operations for the International Space Station (JSC-33408), also developed by the MOD. This paper describes the requirements and process for performing a neutral buoyancy test, including typical hardware and support equipment requirements, personnel and administrative resource requirements, examples of ISS systems and operations that are evaluated, and typical operational objectives that are evaluated.

  12. Direct laboratory tensile testing of select yielding rock bolt systems

    SciTech Connect

    VandeKraats, J.D.; Watson, S.O.

    1996-08-01

    Yielding rock bolt support systems have been developed to accommodate ground movement in shifting ground such as in coal operations; in creeping ground such as salt, trona, and potash; and in swelling ground associated with some clays. These systems, designed to remain intact despite ground movement, should enhance mine safety and help contain costs in areas where rebolting of rigid non-yielding systems is typically required. Four such systems were tested in straight tensile pulls in the laboratory. They include the Slip Nut System from Dywidag Systems International USA, Inc., Ischebeck`s bolt mounted Titan Load Indicator, Rocky Mountain Bolt Company`s Yielding Cable Bolt, and a rock bolt installed variation of the yielding steel post developed by RE/SPEC Inc. The first two systems are currently marketed products and the latter two are prototype systems. Each system responds to load and displacement by yielding in an unique manner. All are designed to yield at predetermined loads. A description of each system and its yield function is provided. Each system was tested over its prescribed yield range in a test machine. At least five tests were performed on each system. Each system yielded and continued to provide support according to its design. Each shows promise for ground control use in shifting or creeping rock. This work helps to illustrate the comparative differences in performance between these specialized systems and the applications where they may be most useful.

  13. 42 CFR 493.1447 - Condition: Laboratories performing high complexity testing; technical supervisor.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; technical supervisor. 493.1447 Section 493.1447 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1447 Condition: Laboratories performing high complexity testing; technical supervisor. The laboratory must have...

  14. 42 CFR 493.1447 - Condition: Laboratories performing high complexity testing; technical supervisor.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; technical supervisor. 493.1447 Section 493.1447 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1447 Condition: Laboratories performing high complexity testing; technical supervisor. The laboratory must have...

  15. 42 CFR 493.1467 - Condition: Laboratories performing high complexity testing; cytology general supervisor.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; cytology general supervisor. 493.1467 Section 493.1467 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1467 Condition: Laboratories performing high complexity testing; cytology general supervisor. For...

  16. 42 CFR 493.1467 - Condition: Laboratories performing high complexity testing; cytology general supervisor.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; cytology general supervisor. 493.1467 Section 493.1467 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1467 Condition: Laboratories performing high complexity testing; cytology general supervisor. For...

  17. 5. Exterior view of Components Test Laboratory (T27), looking northwest. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Exterior view of Components Test Laboratory (T-27), looking northwest. The building wing on the left houses Test Cell 10 (environmental), and that on the right houses Test Cell 9 (fuel) and the fuel storage pit or vault. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  18. 4. Exterior view of Components Test Laboratory (T27), looking northeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Exterior view of Components Test Laboratory (T-27), looking northeast. The building wing on the left houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault, and that on the right houses Test Cell 10 (environmental). - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  19. Cross-Evaluation of Laboratory Permeability Tests by Dimensionless Analysis

    NASA Astrophysics Data System (ADS)

    Takeda, M.; Zhang, M.; Hiratsuka, T.

    2007-12-01

    Accurate estimations of transport parameters of engineered and natural barrier materials are indispensable for assessments of the safety of geological disposal of hazardous wastes including radioactive nuclear waste. In such projects, it is essential that the barrier materials be capable of retarding the migration of contaminants. When groundwater flow is dominant, the evaluation of hydraulic parameters, particularly the permeability and specific storage, is of fundamental importance in the safety assessment. The permeability and specific storage of synthetic and geological materials are measured using permeability tests; however, conventional test methods are routinely applied to barrier materials with relatively low-permeabilities with little knowledge about their applicabilities. In order to provide a theoretical basis for designing laboratory permeability tests, the applicabilites of currently available test methods were examined and cross-evaluated with emphases on the experimental time and the parameter sensitivity using a numerical approach. To allow for a general discussion, a series of examinations were conducted based on a dimensionless analysis using dimensionless parameters representing the hydraulic properties and dimensions of the specimen and the other experimental conditions. In the dimensionless-time scale, the experimental time and the parameter sensitivity of the individual test methods can be simulated and compared by varying a few dimensionless parameters representing the experimental conditions. From a series of examinations, it was found that the experimental time and the parameter sensitivity of the individual test methods can be ascertained and compared using a few dimensionless parameters. This research project has been conducted under the research contract with the Japan Nuclear Energy Safety Organization (JNES).

  20. Standard Hydrogen Test Protocols for the NREL Sensor Testing Laboratory (Brochure)

    SciTech Connect

    Not Available

    2011-12-01

    This brochure summarizes the test protocols used in the NREL Hydrogen Sensor Test Laboratory for the quantitative assessment of critical analytical performance specifications for hydrogen sensors. Researchers at the NREL Hydrogen Safety Sensor Test Laboratory developed a variety of test protocols to quantitatively assess critical analytical performance specifications for hydrogen sensors. Many are similar to, but typically more rigorous than, the test procedures mandated by ISO Standard 26142 (Hydrogen Detector for Stationary Applications). Specific protocols were developed for linear range, short-term stability, and the impact of fluctuations in temperature (T), pressure (P), relative humidity (RH), and chemical environment. Specialized tests (e.g., oxygen requirement) may also be performed. Hydrogen safety sensors selected for evaluation are subjected to a thorough regimen of test protocols, as described. Sensor testing is performed at NREL on custom-built sensor test fixtures. Environmental parameters such as T, P, RH, and gas composition are rigorously controlled and monitored. The NREL evaluations are performed on commercial hydrogen detectors, on emerging sensing technologies, and for end users to validate sensor performance for specific application needs. Test results and data are shared with the manufacturer or client via summary reports, teleconference phone calls, and, when appropriate, site visits to manufacturer facilities. Client representatives may also monitor NREL's operation while their technologies are being tested. Manufacturers may use test data to illustrate the analytical capability of their technologies and, more importantly, to guide future developments. NREL uses the data to assess technology gaps and deployment considerations. Per NREL Sensor Testing Laboratory policy, test results are treated as proprietary and are not shared with other manufacturers or other entities without permission. The data may be used by NREL in open publications

  1. Maize mono-digestion efficiency: results from laboratory tests.

    PubMed

    Ficara, Elena; Malpei, Francesca

    2011-01-01

    A laboratory experimental campaign was carried out in order to assess the optimal configuration for the anaerobic digestion of a mixture of sweet corn and ensiled maize. Batch hydrolysis tests were conducted at 35 and 55 °C and at four different particle sizes (2, 5, 20 and 50 mm) obtained by manual chopping and sieving. Chemical pre-treatment by 24 h incubation at various acid and alkaline pH was also considered for its potential to increase the maize methane yield. Results suggest that the hydrolytic phase proceeds significantly faster under thermophilic conditions. Significant differences in the solubilization rate were also observed when comparing coarse (20-50 mm) with fine (2-5 mm) particles, while 2 and 5 mm particles were solubilized at similar rates. No advantages from the chemical pre-treatment, in terms of solubilization efficiency and biomethanization potential were observed. According to these preliminary results, a two-stage semi-continuous laboratory plant consisting of a thermophilic hydrolytic reactor followed by a mesophilic methanogenic reactor was operated for 110 days. Steady state loading parameters were: influent concentration (maize mixture diluted in tap water) of 46 g VS/L, hydraulic retention time of 31 d, organic loading rate of 1.5 g VS/L/d. Alkalinity was dosed to the methanogenic reactor to avoid pH drops. Collected data allowed the average biodegradation efficiency to be estimated at around 60-65%.

  2. Risk management in the preanalytical phase of laboratory testing.

    PubMed

    Lippi, Giuseppe; Guidi, Gian Cesare

    2007-01-01

    The clinical laboratory is no longer its own limited ecosystem, as it is increasingly integrated with patient care, assisting diagnosis, monitoring therapies and predicting clinical outcomes. Although efforts and resources are continuously focused to achieve a satisfactory degree of analytical quality, there is clear evidence that the preanalytical phase is much more vulnerable to uncertainties and accidents, which can substantially influence patient care. Most errors within the preanalytical phase result from system flaws and insufficient audit of the operators involved in specimen collection and handling responsibilities, leading to an unacceptable number of unsuitable specimens due to in vitro hemolysis, clotting, insufficient volume, wrong container, contamination and misidentification. A reliable approach to overcome this problem entails prediction of accidental events (exhaustive process analysis, reassessment and rearrangement of quality requirements, dissemination of operating guidelines and best-practice recommendations, reduction of complexity and error-prone activities, introduction of error-tracking systems and continuous monitoring of performances), an increase in and diversification of defenses (application of multiple and heterogeneous systems to identify non-conformities), and a decrease in vulnerability (implementation of reliable and objective detection systems and causal relation charts, education and training). This policy, which requires integration between requirements and design, full commitment and interdepartmental cooperation, should make laboratory activity more compliant to the inalienable paradigm of total quality in the testing process.

  3. [Laboratory tests and therapeutic strategies for the porphyrias].

    PubMed

    Poblete-Gutiérrez, P; Wiederholt, T; Merk, H F; Frank, J

    2006-06-01

    The porphyrias are a heterogeneous group of predominantly hereditary metabolic diseases resulting from a dysfunction of heme biosynthesis. Most of the porphyrias can manifest with a broad range of cutaneous symptoms on the sun-exposed areas of the body, whereas other variants reveal life-threatening acute neurological attacks. Further, mixed types of porphyrias exist. Besides the skin, other organs can be affected, such as the liver and the central nervous system. Therefore, interdisciplinary supervision of these patients is mandatory. In this review we will first present the clinical picture and diagnosis of the porphyrias, including the specific biochemical laboratory tests and a diagnostic algorithm. Thereafter, the current therapeutic concepts will be briefly addressed. Finally, we introduce the European Porphyria Initiative (EPI), an association of various European porphyria centers that is aiming at gathering the broad experience of internationally renowned porphyria experts for the development of European consensus guidelines for diagnosis and treatment of these metabolic disorders.

  4. Confidence Intervals for Laboratory Sonic Boom Annoyance Tests

    NASA Technical Reports Server (NTRS)

    Rathsam, Jonathan; Christian, Andrew

    2016-01-01

    Commercial supersonic flight is currently forbidden over land because sonic booms have historically caused unacceptable annoyance levels in overflown communities. NASA is providing data and expertise to noise regulators as they consider relaxing the ban for future quiet supersonic aircraft. One deliverable NASA will provide is a predictive model for indoor annoyance to aid in setting an acceptable quiet sonic boom threshold. A laboratory study was conducted to determine how indoor vibrations caused by sonic booms affect annoyance judgments. The test method required finding the point of subjective equality (PSE) between sonic boom signals that cause vibrations and signals not causing vibrations played at various amplitudes. This presentation focuses on a few statistical techniques for estimating the interval around the PSE. The techniques examined are the Delta Method, Parametric and Nonparametric Bootstrapping, and Bayesian Posterior Estimation.

  5. Sandia National Laboratories' new high level acoustic test facility

    SciTech Connect

    Rogers, J. D.; Hendrick, D. M.

    1989-01-01

    A high intensity acoustic test facility has been designed and is under construction at Sandia National Laboratories in Albuquerque, NM. The chamber is designed to provide an acoustic environment of 154dB (re 20 {mu}Pa) overall sound pressure level over the bandwidth of 50 Hz to 10,000 Hz. The chamber has a volume of 16,000 cubic feet with interior dimensions of 21.6 ft {times} 24.6 ft {times} 30 ft. The construction of the chamber should be complete by the summer of 1990. This paper discusses the design goals and constraints of the facility. The construction characteristics are discussed in detail, as are the acoustic performance design characteristics. The authors hope that this work will help others in designing acoustic chambers. 12 refs., 6 figs.

  6. Laboratory Testing of a Phased Induced Amplitude Apodization (PIAA) Coronagraph

    NASA Technical Reports Server (NTRS)

    Kern, Brian; Guyon, Olivier; Give'on, Amir; Kuhnert, Andreas; Niessner, Albert

    2011-01-01

    We present high-contrast images from laboratory testing of a Phase Induced Amplitude Apodization (PIAA) coronagraph at NASA's High Contrast Imaging Testbed (HCIT). Using a deformable mirror and wavefront estimation and control algorithms, we create a 'dark hole' in the monochromatic point-spread function with an inner working angle of (2.05 f lambda/D), with a mean intensity 3.5x10(exp -8). We discuss the contributions to this floor, and the techniques being developed to improve it. We also present simulations that investigate the effect of Lyot stops of various sizes, and conclude that a Lyot stop is necessary for 10(exp -9) performance but that an annular postapodizer is not necessary.

  7. Test and Validation of the Mars Science Laboratory Robotic Arm

    NASA Technical Reports Server (NTRS)

    Robinson, M.; Collins, C.; Leger, P.; Kim, W.; Carsten, J.; Tompkins, V.; Trebi-Ollennu, A.; Florow, B.

    2013-01-01

    The Mars Science Laboratory Robotic Arm (RA) is a key component for achieving the primary scientific goals of the mission. The RA supports sample acquisition by precisely positioning a scoop above loose regolith or accurately preloading a percussive drill on Martian rocks or rover-mounted organic check materials. It assists sample processing by orienting a sample processing unit called CHIMRA through a series of gravity-relative orientations and sample delivery by positioning the sample portion door above an instrument inlet or the observation tray. In addition the RA facilitates contact science by accurately positioning the dust removal tool, Alpha Particle X-Ray Spectrometer (APXS) and the Mars Hand Lens Imager (MAHLI) relative to surface targets. In order to fulfill these seemingly disparate science objectives the RA must satisfy a variety of accuracy and performance requirements. This paper describes the necessary arm requirement specification and the test campaign to demonstrate these requirements were satisfied.

  8. Test and Validation of the Mars Science Laboratory Robotic Arm

    NASA Technical Reports Server (NTRS)

    Robinson, M.; Collins, C.; Leger, P.; Kim, W.; Carsten, J.; Tompkins, V.; Trebi-Ollennu, A.; Florow, B.

    2013-01-01

    The Mars Science Laboratory Robotic Arm (RA) is a key component for achieving the primary scientific goals of the mission. The RA supports sample acquisition by precisely positioning a scoop above loose regolith or accurately preloading a percussive drill on Martian rocks or rover-mounted organic check materials. It assists sample processing by orienting a sample processing unit called CHIMRA through a series of gravity-relative orientations and sample delivery by positioning the sample portion door above an instrument inlet or the observation tray. In addition the RA facilitates contact science by accurately positioning the dust removal tool, Alpha Particle X-Ray Spectrometer (APXS) and the Mars Hand Lens Imager (MAHLI) relative to surface targets. In order to fulfill these seemingly disparate science objectives the RA must satisfy a variety of accuracy and performance requirements. This paper describes the necessary arm requirement specification and the test campaign to demonstrate these requirements were satisfied.

  9. Laboratory tests of IEC DER object models for grid applications.

    SciTech Connect

    Blevins, John D.; Menicucci, David F.; Byrd, Thomas, Jr.; Gonzalez, Sigifredo; Ginn, Jerry W.; Ortiz-Moyet, Juan

    2007-02-01

    This report describes a Cooperative Research and Development Agreement (CRADA) between Salt River Project Agricultural Improvement and Power District (SRP) and Sandia National Laboratories to jointly develop advanced methods of controlling distributed energy resources (DERs) that may be located within SRP distribution systems. The controls must provide a standardized interface to allow plug-and-play capability and should allow utilities to take advantage of advanced capabilities of DERs to provide a value beyond offsetting load power. To do this, Sandia and SRP field-tested the IEC 61850-7-420 DER object model (OM) in a grid environment, with the goal of validating whether the model is robust enough to be used in common utility applications. The diesel generator OM tested was successfully used to accomplish basic genset control and monitoring. However, as presently constituted it does not enable plug-and-play functionality. Suggestions are made of aspects of the standard that need further development and testing. These problems are far from insurmountable and do not imply anything fundamentally unsound or unworkable in the standard.

  10. Dynamic Stability Testing of the Mars Science Laboratory Entry Capsule

    NASA Technical Reports Server (NTRS)

    Schroenenberger, Mark; Yates, Leslie; Hathaway, Wayne

    2009-01-01

    Results from a 26 shot ballistic range test of the Mars Science Laboratory (MSL) entry capsule are presented. The supersonic pitch damping properties of the MSL capsule were characterized between Mach 1.35 and Mach 3.5 and total angles-of-attack from 0 to 30 degrees. In flight, the MSL entry capsule will utilize a radial center-of-gravity offset to produce a non-zero trim angle-of-attack. This offset trim angle will produce lift, enabling the capsule to fly a guided entry and reducing the landing footprint dimensions to within 10 km of the desired landing site. A lifting configuration could not be tested at the ballistic range used for this test as the models would swerve into the range walls, possibly damaging cameras, the coordinate reference system or other facility assets. Ballistic (non-lifting) data was extracted and will be implemented in a conservative fashion to ensure that the dynamic stability characteristics of the flight vehicle are bounded. A comparison between the MSL pitch damping results and the dynamic model of the Mars Exploration Rover capsule shows generally close agreement with no significant differences in damping characteristics due to the change in backshell geometry. Dynamic moments are also compared to the MSL reaction control system (RCS) control authority to show the controller has sufficient margin to easily damp any dynamic stability effects.

  11. Tests for oil/dispersant toxicity: In situ laboratory assays

    SciTech Connect

    Wright, D.A.; Coelho, G.M.; Aurand, D.V.

    1995-12-31

    As part of its readiness program in oil spill response, the Marine Pollution Control Unit (MPCU), Department of Transport, U.K. conducts annual field trials in the North Sea, approximately 30 nautical miles from the southeast coast of England. The trials take the form of controlled releases of crude oil or Medium Fuel/Gas Oil mix (MFO), with and without the application of Corexit 9527 dispersant. In 1994 and 1995 the authors conducted a series of in situ toxicity bioassays in association with these spills with included 48h LC50 tests for turbot (Scophthalmus maximus) and oyster (Crassostrea gigas) larvae, a 48 h oyster (C. gigas) embryonic development test and two full life-cycle assays using the copepods Acartia tonsa and Tisbe battagliai. Tests were also conducted in the Chesapeake Bay laboratory using estuarine species including the copepod Eurytemora affinis and the inland silverside Menidia beryllina. Here, the authors report on the results of these assays, together with 1996 in situ toxicity data resulting from Norwegian field trials in the northern North Sea.

  12. Turbulent Aeroheating Testing of Mars Science Laboratory Entry Vehicle

    NASA Technical Reports Server (NTRS)

    Hollis, Brian R.; Collier, Arnold S.

    2008-01-01

    An experimental investigation of turbulent aeroheating on the Mars Science Laboratory entry vehicle heat shield has been conducted in the Arnold Engineering Development Center Hypervelocity Wind Tunnel No. 9. Testing was performed on a 6-in. (0.1524 m) diameter MSL model in pure N2 gas in the tunnel's Mach 8 and Mach 10 nozzles at free stream Reynolds numbers of 4.1 x 10(exp 6)/ft to 49 x 10(exp 6)/ft (1.3 x 10(exp 7)/m to 19 x 10(exp 6/ft) and 1.2 x 10(exp 6)/ft to 19 x 10(exp 6)/ft (0.39 x 10(exp 7)/m to 62 x 10(exp 7)/m), respectively. These conditions were sufficient to span the regime of boundary-layer flow from completely laminar to fully-developed turbulent flow over the entire forebody. A supporting aeroheating test was also conducted in the Langley Research Center 20-Inch Mach 6 Air Tunnel at free stream Reynolds number of 1 x 10(exp 6)/ft to 7 x 10(exp 6)/ft (0.36 x 10(exp 7)/m to 2.2 x 10(exp 7)/m) in order to help corroborate the Tunnel 9 results. A complementary computational fluid dynamics study was conducted in parallel to the wind tunnel testing. Laminar and turbulent predictions were generated for the wind tunnel test conditions and comparisons were performed with the data for the purpose of helping to define uncertainty margins on predictions for aeroheating environments during entry into the Martian atmosphere. Data from both wind tunnel tests and comparisons with the predictions are presented herein. It was concluded from these comparisons that for perfect-gas conditions, the computational tools could predict fully-laminar or fully-turbulent heating conditions to within 12% or better of the experimental data.

  13. Portable nondestructive testing and dynamic test diagnostics at Los Alamos National Laboratory

    SciTech Connect

    Fry, D.A.; Brooks, G.H.; Bryant, L.E.; Guerrero, A.; Valdez, J.E.

    1994-11-01

    Los Alamos National Laboratory maintains one of the most complete NDT facilities worldwide. In addition to many fixed pieces of equipment, the Laboratory has a very wide range of NDT and dynamic test diagnostic equipment that can be taken to the job site. Most of the equipment described here was procured for a specific purpose to support a program consistent with the nuclear weapons mission of Los Alamos. However, through the years, the equipment has found use in many other applications both within and external to weapons research, development, and testing. Various combinations of these equipments form unique capabilities, as demonstrated by the applications. The portable equipment is mainly applied to problems where the process or object under study cannot be brought into an NDT laboratory.

  14. Investigations of engine oil shear stability in laboratory tests and road tests

    SciTech Connect

    Rein, S.W.; Alexander, D.L.; Cryvoff, S.A.; Dahlstrom, M.A.

    1987-01-01

    The relationship of shear stability in laboratory tests to shear stability in service was investigated in a diesel injector test, in the L-38 single-cylinder engine, in a multi-cylinder engine equipped for bearing film thickness measurement, and in road testing in an automobile and in trucks. All of the laboratory and road tests differed in severity of shearing and also showed that major VI improver types differed in the time needed for their kinematic viscosity to approach a fully-sheared value. Shear stability comparisons based on kinematic viscosities measured during the transition to the fully sheared condition did not accurately represent the relative shear stability of VI improvers in the fully-sheared condition. In the road tests, most of the oils were at their fully-sheared viscosity for the major part of their service life. The decrease of HTHS viscosity due to shearing in the road test and laboratory engines was usually less than half the kinematic viscosity decrease. Bearing oil film thicknesses showed little or no change with test duration in the multicylinder lab engine and correlate well with HTHS viscosity.

  15. 76 FR 39110 - Medicare Program; Section 3113: The Treatment of Certain Complex Diagnostic Laboratory Tests...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Medicare Program; Section 3113: The Treatment of... participate in the Treatment of Certain Complex Diagnostic Laboratory Tests Demonstration. The Demonstration... Treatment of Certain Complex Diagnostic Laboratory Tests Demonstration. The authorizing legislation...

  16. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Engineers and District Engineers operating hydraulic laboratories or hydraulic model laboratories are... (DAEN-CWE-DC) Washington, DC 20314. Copies of reports of scientific or technical activities will be...

  17. Survey of antimicrobial susceptibility testing practices of veterinary diagnostic laboratories in the United States.

    PubMed

    Brooks, Matthew B; Morley, Paul S; Dargatz, David A; Hyatt, Doreene R; Salman, M D; Akey, Bruce L

    2003-01-15

    To describe antimicrobial susceptibility testing practices of veterinary diagnostic laboratories in the United States and evaluate the feasibility of collating this information for the purpose of monitoring antimicrobial resistance in bacterial isolates from animals. Cross-sectional study. A questionnaire was mailed to veterinary diagnostic laboratories throughout the United States to identify those laboratories that conduct susceptibility testing. Nonrespondent laboratories were followed up through telephone contact and additional mailings. Data were gathered regarding methods of susceptibility testing, standardization of methods, data management, and types of isolates tested. Eighty-six of 113 (76%) laboratories responded to the survey, and 64 of the 86 (74%) routinely performed susceptibility testing on bacterial isolates from animals. Thirty-four of the 36 (94%) laboratories accredited by the American Association of Veterinary Laboratory Diagnosticians responded to the survey. Laboratories reported testing > 160,000 bacterial isolates/y. Fifty-one (88%) laboratories reported using the Kirby-Bauer disk diffusion test to evaluate antimicrobial susceptibility; this accounted for 65% of the isolates tested. Most (87%) laboratories used the NCCLS (National Committee for Clinical Laboratory Standards) documents for test interpretation. Seventy-five percent of the laboratories performed susceptibility testing on bacterial isolates only when they were potential pathogens. The veterinary diagnostic laboratories represent a comprehensive source of data that is not easily accessible in the United States. Variability in testing methods and data storage would present challenges for data aggregation, summary, and interpretation.

  18. NASA Glenn Research Center Acoustical Testing Laboratory: Five year retrospective

    NASA Astrophysics Data System (ADS)

    Cooper, Beth A.; Akers, James C.; Passe, Paul J.

    2005-09-01

    In the five years since the NASA Glenn Research Center Acoustical Testing Laboratory (ATL) opened its doors in September, 2000, it has developed a comprehensive array of services and products that support hearing conservation goals within NASA and industry. The ATL provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL aggressively supports the vision of a low-noise on-orbit environment, which facilitates mission success as well as crew health, safety, and comfort. In concert with these goals, the ATL also produces and distributes free educational resources and low-noise advocacy tools for hearing conservation education and awareness. Among these are two compact discs of auditory demonstrations (of phenomena in acoustics, hearing conservation, and communication), and presentations, software packages, and other educational materials for use by engineers, audiologists, and other hearing conservation stakeholders. This presentation will highlight ATL's construction, history, technical capabilities, and current projects and will feature demonstrations of some of the unique educational resource materials that are distributed by the ATL.

  19. Interference of medical contrast media on laboratory testing.

    PubMed

    Lippi, Giuseppe; Daves, Massimo; Mattiuzzi, Camilla

    2014-01-01

    The use of contrast media such as organic iodine molecules and gadolinium contrast agents is commonplace in diagnostic imaging. Although there is widespread perception that side effects and drug interactions may be the leading problems caused by these compounds, various degrees of interference with some laboratory tests have been clearly demonstrated. Overall, the described interference for iodinate contrast media include inappropriate gel barrier formation in blood tubes, the appearance of abnormal peaks in capillary zone electrophoresis of serum proteins, and a positive bias in assessment of cardiac troponin I with one immunoassay. The interference for gadolinium contrast agents include negative bias in calcium assessment with ortho-cresolphthalein colorimetric assays and occasional positive bias using some Arsenazo reagents, negative bias in measurement of angiotensin converting enzyme (ACE) and zinc (colorimetric assay), as well as positive bias in creatinine (Jaffe reaction), total iron binding capacity (TIBC, ferrozine method), magnesium (calmagite reagent) and selenium (mass spectrometry) measurement. Interference has also been reported in assessment of serum indices, pulse oximetry and methaemoglobin in samples of patients receiving Patent Blue V. Under several circumstances the interference was absent from manufacturer-supplied information and limited to certain type of reagents and/or analytes, so that local verification may be advisable to establish whether or not the test in use may be biased. Since the elimination half-life of these compounds is typically lower than 2 h, blood collection after this period may be a safer alternative in patients who have received contrast media for diagnostic purposes.

  20. Parachute Opening During Tests for Mars Science Laboratory

    NASA Image and Video Library

    2009-04-22

    Testing during March and April 2009 inside the world largest wind tunnel, at NASA Ames Research Center, Moffett Field, Calif., qualified the parachute for NASA next Mars rover. The parachute for NASA's Mars Science Laboratory mission, to be launched in 2011 and land on Mars in 2012, is the largest ever built to fly on an extraterrestrial mission. This image shows the qualification-test parachute beginning to open a few seconds after it was launched from a mortar into an 80-mile-per-hour (36-meter-per-second) wind. The parachute uses a configuration called disk-gap-band. It has 80 suspension lines, measures more than 50 meters (165 feet) in length, and opens to a diameter of nearly 16 meters (51 feet). Most of the orange and white fabric is nylon, though a small disk of heavier polyester is used near the vent in the apex of the canopy due to higher stresses there. http://photojournal.jpl.nasa.gov/catalog/PIA11993

  1. Parachute Opening During Tests for Mars Science Laboratory

    NASA Image and Video Library

    2009-04-22

    Testing during March and April 2009 inside the world largest wind tunnel, at NASA Ames Research Center, Moffett Field, Calif., qualified the parachute for NASA next Mars rover. The parachute for NASA's Mars Science Laboratory mission, to be launched in 2011 and land on Mars in 2012, is the largest ever built to fly on an extraterrestrial mission. This image shows the qualification-test parachute beginning to open a few seconds after it was launched from a mortar into an 80-mile-per-hour (36-meter-per-second) wind. The parachute uses a configuration called disk-gap-band. It has 80 suspension lines, measures more than 50 meters (165 feet) in length, and opens to a diameter of nearly 16 meters (51 feet). Most of the orange and white fabric is nylon, though a small disk of heavier polyester is used near the vent in the apex of the canopy due to higher stresses there. http://photojournal.jpl.nasa.gov/catalog/PIA11992

  2. 42 CFR 493.1361 - Condition: Laboratories performing PPM procedures; testing personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; testing personnel. 493.1361 Section 493.1361 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1361 Condition: Laboratories performing PPM procedures; testing personnel. The laboratory must have...

  3. 42 CFR 493.1361 - Condition: Laboratories performing PPM procedures; testing personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; testing personnel. 493.1361 Section 493.1361 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1361 Condition: Laboratories performing PPM procedures; testing personnel. The laboratory must have...

  4. 3. Exterior view of Components Test Laboratory (T27), looking southeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Exterior view of Components Test Laboratory (T-27), looking southeast. The building wing on the left houses the equipment room, and that on the right houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  5. 2. Exterior view of Components Test Laboratory (T27), looking southeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Exterior view of Components Test Laboratory (T-27), looking southeast. The building wing on the left houses the equipment room and that on the right houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  6. 78 FR 60898 - Regulation on Definition and Requirements for a Nationally Recognized Testing Laboratory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...: Definition and Requirements of a Nationally Recognized Testing Laboratory (29 CFR 1910.7). OMB Control Number... Recognized Testing Laboratory; Revision of the Office of Management and Budget's (OMB) Approval of..., ``definition and requirements for a nationally recognized testing laboratory'' (The Regulation). The...

  7. 42 CFR 493.1481 - Condition: Laboratories performing high complexity testing; cytotechnologist.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1481 Condition: Laboratories performing high complexity testing; cytotechnologist. For the subspecialty of...

  8. Transportable Heavy Duty Emissions Testing Laboratory and Research Program

    SciTech Connect

    David Lyons

    2008-03-31

    The objective of this program was to quantify the emissions from heavy-duty vehicles operating on alternative fuels or advanced fuel blends, often with novel engine technology or aftertreatment. In the first year of the program West Virginia University (WVU) researchers determined that a transportable chassis dynamometer emissions measurement approach was required so that fleets of trucks and buses did not need to be ferried across the nation to a fixed facility. A Transportable Heavy-Duty Vehicle Emissions Testing Laboratory (Translab) was designed, constructed and verified. This laboratory consisted of a chassis dynamometer semi-trailer and an analytic trailer housing a full scale exhaust dilution tunnel and sampling system which mimicked closely the system described in the Code of Federal Regulations for engine certification. The Translab was first used to quantify emissions from natural gas and methanol fueled transit buses, and a second Translab unit was constructed to satisfy research demand. Subsequent emissions measurement was performed on trucks and buses using ethanol, Fischer-Tropsch fuel, and biodiesel. A medium-duty chassis dynamometer was also designed and constructed to facilitate research on delivery vehicles in the 10,000 to 20,000lb range. The Translab participated in major programs to evaluate low-sulfur diesel in conjunction with passively regenerating exhaust particulate filtration technology, and substantial reductions in particulate matter were recorded. The researchers also participated in programs to evaluate emissions from advanced natural gas engines with closed loop feedback control. These natural gas engines showed substantially reduced levels of oxides of nitrogen. For all of the trucks and buses characterized, the levels of carbon monoxide, oxides of nitrogen, hydrocarbons, carbon dioxide and particulate matter were quantified, and in many cases non-regulated species such as aldehydes were also sampled. Particle size was also

  9. Response of shallow geothermal energy pile from laboratory model tests

    NASA Astrophysics Data System (ADS)

    Marto, A.; Amaludin, A.

    2015-09-01

    In shallow geothermal energy pile systems, the thermal loads from the pile, transferred and stored in the soil will cause thermally induced settlement. This factor must be considered in the geotechnical design process to avoid unexpected hazards. Series of laboratory model tests were carried out to study the behaviour of energy piles installed in kaolin soil, subjected to thermal loads and a combination of axial and thermal loads (henceforth known as thermo-axial loads). Six tests which included two thermal load tests (35°C and 40°C) and four thermo-axial load tests (100 N and 200 N, combined with 35°C and 40°C thermal loads) were conducted. To simulate the behaviour of geothermal energy piles during its operation, the thermo-axial tests were carried out by applying an axial load to the model pile head, and a subsequent application of thermal load. The model soil was compacted at 90% maximum dry density and had an undrained shear strength of 37 kPa, thus classified as having a firm soil consistency. The behaviour of model pile, having the ultimate load capacity of 460 N, was monitored using a linear variable displacement transducer, load cell and wire thermocouple, to measure the pile head settlement, applied axial load and model pile temperature. The acquired data from this study was used to define the thermo-axial response characteristics of the energy pile model. In this study, the limiting settlement was defined as 10% of the model pile diameter. For thermal load tests, higher thermal loads induced higher values of thermal settlement. At 40°C thermal load an irreversible settlement was observed after the heating and cooling cycle was applied to the model pile. Meanwhile, the pile response to thermo-axial loads were attributed to soil consistency and the magnitude of both the axial and thermal loads applied to the pile. The higher the thermoaxial loads, the higher the settlements occurred. A slight hazard on the model pile was detected, since the settlement

  10. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... trained by the National Veterinary Services Laboratories (NVSL) or who have completed equivalent training... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Approval of laboratories to run... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and university...

  11. Laboratory expenditure in Pegasus Medical Group: a comparison of high and low users of laboratory tests with academics.

    PubMed

    Malcolm, L; Wright, L; Seers, M; Davies, L; Guthrie, J

    2000-03-10

    To determine, through the use of clinical vignettes, whether low and high cost users of laboratory tests in Pegasus Medical Group (Pegasus) differed in their choice of laboratory tests from academics as a means of further investigating issues relating to quality and cost in laboratory testing. Seven clinical vignettes were drawn up and sent to 30 selected members in Pegasus whose actual laboratory expenditure per consultation ranged from a mean of $2.3 in a low cost group (15 members) to $12.2 in a high cost group (15 members). The vignettes were also sent to 15 general practitioner academics. Respondents were requested to complete a laboratory form as to which tests they would use for each individual scenario. The answers were analysed for overall cost as well as numbers of laboratory tests requested. There were 14 academic responses and 13 each from the bottom and top laboratory users. Overall results for the seven vignette cases showed that low cost laboratory users would spend a total of $176.3, the academics $188.8, and the high cost users $219.5 on the cases. The mean per case costs were $25.2, $27.0 and $31.4 respectively. There was a clear tendency for high volume users of tests in each vignette to be high in others suggesting that doctor rather than patient factors were the main explanation of the variation. Clinical vignettes do not appear to be a useful strategy in clarifying issues related to quality and cost in laboratory utilisation. Test ordering behaviour appears, from the international literature and this study, to be determined more by personal doctor factors than by objective evidence and clinical need. Further work is needed to clarify the relationship between quality and the wide variation observed in utilisation and expenditure.

  12. Internship at NASA Kennedy Space Center's Cryogenic Test laboratory

    NASA Technical Reports Server (NTRS)

    Holland, Katherine

    2013-01-01

    NASA's Kennedy Space Center (KSC) is known for hosting all of the United States manned rocket launches as well as many unmanned launches at low inclinations. Even though the Space Shuttle recently retired, they are continuing to support unmanned launches and modifying manned launch facilities. Before a rocket can be launched, it has to go through months of preparation, called processing. Pieces of a rocket and its payload may come in from anywhere in the nation or even the world. The facilities all around the center help integrate the rocket and prepare it for launch. As NASA prepares for the Space Launch System, a rocket designed to take astronauts beyond Low Earth Orbit throughout the solar system, technology development is crucial for enhancing launch capabilities at the KSC. The Cryogenics Test Laboratory at Kennedy Space Center greatly contributes to cryogenic research and technology development. The engineers and technicians that work there come up with new ways to efficiently store and transfer liquid cryogens. NASA has a great need for this research and technology development as it deals with cryogenic liquid hydrogen and liquid oxygen for rocket fuel, as well as long term space flight applications. Additionally, in this new era of space exploration, the Cryogenics Test Laboratory works with the commercial sector. One technology development project is the Liquid Hydrogen (LH2) Ground Operations Demonstration Unit (GODU). LH2 GODU intends to demonstrate increased efficiency in storing and transferring liquid hydrogen during processing, loading, launch and spaceflight of a spacecraft. During the Shuttle Program, only 55% of hydrogen purchased was used by the Space Shuttle Main Engines. GODU's goal is to demonstrate that this percentage can be increased to 75%. Figure 2 shows the GODU layout when I concluded my internship. The site will include a 33,000 gallon hydrogen tank (shown in cyan) with a heat exchanger inside the hydrogen tank attached to a

  13. Laboratory testing of a lethal ovitrap for Aedes aegypti.

    PubMed

    Zeichner, B C; Perich, M J

    1999-07-01

    Laboratory tests were conducted to determine the feasibility of making the mosquito ovitrap lethal to Aedes aegypti (L.) when they attempt to oviposit in the trap. Heavy-weight velour paper strips (2.54 x 11 cm) were used as an alternative to the wooden paddle normally provided as a substrate for mosquito oviposition. The paper strips were pretreated with insecticide solutions and allowed to dry before being used in oviposition cups of 473 ml capacity, filled with water initially to within 2.5 cm of the brim. Insecticides chosen for their quick knock-down efficacy were bendiocarb 76% WP (1.06 mg a.i./strip) and four pyrethroids: permethrin 25% WP (0.16 mg a.i./strip), deltamethin 4.75% SC (0.87 mg a.i./strip), cypermethrin 40% WP (2.81 mg a.i./strip), and cyfluthrin 20% WP (0.57 mg a.i./ strip). For experimental evaluation, two oviposition cups (one with an insecticide-treated strip and one with an untreated strip) were placed in cages (cubic 30 cm) with gravid female Ae. aegypti mosquitoes (aged 6-8 days) from a susceptible laboratory strain. Mortality-rates of female mosquitoes were 45% for bendiocarb, 47% for permethrin, 98% for deltamethrin, 100% for cypermethrin, and 100% for cyfluthrin. Young instar larvae added to the treated cups died within 2h. After water evaporation from the cups for 38 days, fresh mosquito females had access to previously submerged portions of the velour paper paddle, and mortality rates of 59% or more occurred. Cups that had water (360 ml) dripped into them, to simulate rain, produced female mosquito mortality rates of > 50% and all larvae died within 3 h of being added. These tests demonstrate that the ovitrap can be made lethal to both adults and larvae by insecticidal treatment of the ovistrip. Field efficacy trials are underway in Brazil to access the impact of this simple, low-cost, environmentally benign approach on populations of the dengue vector Ae. aegypti.

  14. Results from laboratory and field testing of nitrate measuring spectrophotometers

    USGS Publications Warehouse

    Snazelle, Teri T.

    2015-01-01

    In Phase II, the analyzers were deployed in field conditions at three diferent USGS sites. The measured nitrate concentrations were compared to discrete (reference) samples analyzed by the Direct UV method on a Shimadzu UV1800 bench top spectrophotometer, and by the National Environmental Methods Index (NEMI) method I-2548-11 at the USGS National Water Quality Laboratory. The first deployment at USGS site 0249620 on the East Pearl River in Hancock County, Mississippi, tested the ability of the TriOs ProPs (10-mm path length), Hach NITRATAX (5 mm), Satlantic SUNA (10 mm), and the S::CAN Spectro::lyser (5 mm) to accurately measure low-level (less than 2 mg-N/L) nitrate concentrations while observing the effect turbidity and colored dissolved organic matter (CDOM) would have on the analyzers' measurements. The second deployment at USGS site 01389005 Passaic River below Pompton River at Two Bridges, New Jersey, tested the analyzer's accuracy in mid-level (2-8 mg-N/L) nitrate concentrations. This site provided the means to test the analyzers' performance in two distinct matrices—the Passaic and the Pompton Rivers. In this deployment, three instruments tested in Phase I (TriOS, Hach, and SUNA) were deployed with the S::CAN Spectro::lyser (35 mm) already placed by the New Jersey Water Science Center (WSC). The third deployment at USGS site 05579610 Kickapoo Creek at 2100E Road near Bloomington, Illinois, tested the ability of the analyzers to measure high nitrate concentrations (greater than 8 mg-N/L) in turbid waters. For Kickapoo Creek, the HIF provided the TriOS (10 mm) and S::CAN (5 mm) from Phase I, and a SUNA V2 (5 mm) to be deployed adjacent to the Illinois WSC-owned Hach (2 mm). A total of 40 discrete samples were collected from the three deployment sites and analyzed. The nitrate concentration of the samples ranged from 0.3–22.2 mg-N/L. The average absolute difference between the TriOS measurements and discrete samples was 0.46 mg-N/L. For the combined data

  15. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Approval of laboratories to run official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and...

  16. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Approval of laboratories to run official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and...

  17. 7 CFR 3300.91 - List of approved testing stations, approved testing laboratories, and fees for certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CARRIAGE OF PERISHABLE FOODSTUFFS AND ON THE SPECIAL EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP... testing stations, approved testing laboratories, and fees for certificates. A current list of U.S. ATP testing stations, U.S. ATP testing laboratories, and fees for issuance of U.S. ATP certificates may...

  18. 7 CFR 3300.91 - List of approved testing stations, approved testing laboratories, and fees for certificates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CARRIAGE OF PERISHABLE FOODSTUFFS AND ON THE SPECIAL EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP... testing stations, approved testing laboratories, and fees for certificates. A current list of U.S. ATP testing stations, U.S. ATP testing laboratories, and fees for issuance of U.S. ATP certificates may be...

  19. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2012-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory.

  20. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2011-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory

  1. Mycobacterium tuberculosis testing practices in hospital, commercial and state laboratories in the New England states.

    PubMed

    Livingston, K A; Lobato, M N; Sosa, L E; Budnick, G E; Bernardo, J

    2011-09-01

    The mycobacterial laboratory is assuming an increasingly important role in tuberculosis (TB) control in the United States today. To assess mycobacterial laboratory capacity and practices in the New England states, USA. We surveyed 143 hospital and commercial laboratories and five of the six state public health laboratories in New England that offer testing services for Mycobacterium tuberculosis. The survey captured information on types of services offered and volume of testing, use of state laboratories for testing, and promptness of reporting results to TB control programs. State laboratories perform the majority of testing services, particularly for more specialized tests. All state laboratories surveyed perform species identification of acid-fast isolates, culture and first-line drug susceptibility testing. Less than 20% of hospital and commercial laboratories offer these services, and 78.6% of hospitals and commercial laboratories refer specimens to state laboratories for culture. Surveys of M. tuberculosis testing capacities in a region can help decision makers ensure maintenance of essential services. Hospital and commercial laboratories with lower testing volume might increase efficiency by referring more specimens to state laboratories. State health departments might consider organizing regional laboratory service networks to monitor the provision of services, improve efficiency and oversee quality improvement initiatives.

  2. Blood-based biomarkers for Parkinson's disease.

    PubMed

    Chahine, Lama M; Stern, Matthew B; Chen-Plotkin, Alice

    2014-01-01

    There is a pressing need for biomarkers to diagnose Parkinson's disease (PD), assess disease severity, and prognosticate course. Various types of biologic specimens are potential candidates for identifying biomarkers--defined here as surrogate indicators of physiological or pathophysiological states--but blood has the advantage of being minimally invasive to obtain. There are, however, several challenges to identifying biomarkers in blood. Several candidate biomarkers identified in other diseases or in other types of biological fluids are being pursued as blood-based biomarkers in PD. In addition, unbiased discovery is underway using techniques including metabolomics, proteomics, and gene expression profiling. In this review, we summarize these techniques and discuss the challenges and successes of blood-based biomarker discovery in PD. Blood-based biomarkers that are discussed include α-synuclein, DJ-1, uric acid, epidermal growth factor, apolipoprotein-A1, and peripheral inflammatory markers.

  3. 77 FR 39501 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... Laboratory, 11401 I-30, Little Rock, AR 72209-7056, 501-202-2783, (Formerly: Forensic Toxicology Laboratory..., 503-413-5295/800-950-5295 Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory..., Suite 208, Columbia, MO 65203, 573-882-1273 U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490...

  4. 78 FR 39757 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... Laboratory, 11401 I-30, Little Rock, AR 72209-7056, 501-202-2783, (Formerly: Forensic Toxicology Laboratory... Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725-2088 National... 65203, 573-882-1273 US Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St., Fort George G...

  5. Weapons Evaluation Test Laboratory at Pantex: Testing and data handling capabilities of Sandia National Laboratories at the Pantex Plant, Amarillo, Texas

    SciTech Connect

    Peters, W.R.

    1993-08-01

    The Weapons Evaluation Test Laboratory (WETL), operated by Sandia Laboratories at the Pantex Plant in Amarillo, Texas, is engaged primarily in the testing of weapon systems in the stockpile or of newly produced weapon systems for the Sandia Surety Assessment Center. However, the WETL`s unique testing equipment and data-handling facilities are frequently used to serve other organizations. Service to other organizations includes performing special tests on weapon components, subassemblies, and systems for purposes such as basic development and specific problem investigation. The WETL staff also sends equipment to other laboratories for specific tests that cannot be performed at Pantex. For example, we modified and sent equipment to Brookhaven National Laboratory for testing with their Neutral Particle Beam. WETL supplied the engineering expertise to accomplish the needed modifications to the equipment and the technicians to help perform many special tests at Brookhaven. A variety of testing is possible within the WETL, including: Accelerometer, decelerometer, and G-switch g-level/closure testing; Neutron generator performance testing; weapon systems developmental tests; weapon system component testing; weapon system failure-mode-duplication tests; simultaneity measurements; environmental extreme testing; parachute deployment testing; permissive action link (PAL) testing and trajectory-sensing signal generator (TSSG) testing. WETL`s existing equipment configurations do not restrict the testing performed at the WETL. Equipment and facilities are adapted to specific requirements. The WETL`s facilities can often eliminate the need to build or acquire new test equipment, thereby saving time and expense.

  6. Design of a laboratory simulator to test exoplanet imaging polarimetry

    NASA Astrophysics Data System (ADS)

    Jeffers, S. V.; Miesen, N.; Rodenhuis, M.; Keller, C. U.

    2008-07-01

    Research on extrasolar planets is one of the most rapidly advancing fields of astrophysics. In just over a decade since the discovery of the first extra-solar planet orbiting around 51 Pegasi, 289 extrasolar planets have been discovered. This breakthrough is the result of the development of a wide range of new observational techniques and facilities for the detection and characterisation of extrasolar planets. In Utrecht we are building the Extreme Polarimeter (ExPo) to image extra-solar planets and circumstellar environments using polarimetry at contrast ratio of 10-9. To test and calibrate ExPo, we have built a laboratory-based simulator that mimics a star with a Jupiter-like exoplanet as seen by the 4.2m William Herschel Telescope. The star and planet are simulated using two single-mode fibres in close proximity that are fed with a broadband arc lamp with a contrast ratio down to 10-9. The planet is partially linearly polarized. The telescope is simulated with two lenses, and seeing can be included with a rotating glass plate covered with hairspray. In this paper we present the scientific requirements and the simulator design.

  7. Laboratory testing of cement grouting of fractures in welded tuff

    SciTech Connect

    Sharpe, C.J.; Daemen, J.J.

    1991-03-01

    Fractures in the rock mass surrounding a repository and its shafts, access drifts, emplacement rooms and holes, and exploratory or in-situ testing holes, may provide preferential flowpaths for the flow of groundwater or air, potentially containing radionuclides. Such cracks may have to be sealed. The likelihood that extensive or at least local grouting will be required as part of repository sealing has been noted in numerous publications addressing high level waste repository closing. The objective of this work is to determine the effectiveness of fracture sealing (grouting) in welded tuff. Experimental work includes measurement of intact and fracture permeability under various normal stresses and injection pressures. Grout is injected into the fractures. The effectiveness of grouting is evaluated in terms of grout penetration and permeability reduction, compared prior to and after grouting. Analysis of the results include the effect of normal stress, injection pressure, fracture roughness, grout rheology, grout bonding, and the radial extent of grout penetration. Laboratory experiments have been performed on seventeen tuff cylinders with three types of fractures: (1) tension induced cracks, (2) natural fractures, and (3) sawcuts. Prior to grouting, the hydraulic conductivity of the intact rock and of the fractures is measured under a range of normal stresses. The surface topography of the fracture is mapped, and the results are used to determine aperture distributions across the fractures. 72 refs., 76 figs., 25 tabs.

  8. Laboratory testing of candidate robotic applications for space

    NASA Technical Reports Server (NTRS)

    Purves, R. B.

    1987-01-01

    Robots have potential for increasing the value of man's presence in space. Some categories with potential benefit are: (1) performing extravehicular tasks like satellite and station servicing, (2) supporting the science mission of the station by manipulating experiment tasks, and (3) performing intravehicular activities which would be boring, tedious, exacting, or otherwise unpleasant for astronauts. An important issue in space robotics is selection of an appropriate level of autonomy. In broad terms three levels of autonomy can be defined: (1) teleoperated - an operator explicitly controls robot movement; (2) telerobotic - an operator controls the robot directly, but by high-level commands, without, for example, detailed control of trajectories; and (3) autonomous - an operator supplies a single high-level command, the robot does all necessary task sequencing and planning to satisfy the command. Researchers chose three projects for their exploration of technology and implementation issues in space robots, one each of the three application areas, each with a different level of autonomy. The projects were: (1) satellite servicing - teleoperated; (2) laboratory assistant - telerobotic; and (3) on-orbit inventory manager - autonomous. These projects are described and some results of testing are summarized.

  9. Emissions from laboratory combustor tests of manufactured wood products

    SciTech Connect

    Wilkening, R.; Evans, M.; Ragland, K.; Baker, A.

    1993-12-31

    Manufactured wood products contain wood, wood fiber, and materials added during manufacture of the product. Manufacturing residues and the used products are burned in a furnace or boiler instead of landfilling. Emissions from combustion of these products contain additional compounds from the combustion of non-wood material which have not been adequately characterized to specify the best combustion conditions, emissions control equipment, and disposal procedures. Total hydrocarbons, formaldehyde, higher aldehydes and carbon monoxide emissions from aspen flakeboard and aspen cubes were measured in a 76 mm i.d. by 1.5 m long fixed bed combustor as a function of excess oxygen, and temperature. Emissions of hydrocarbons, aldehydes and CO from flakeboard and from clean aspen were very sensitive to average combustor temperature and excess oxygen. Hydrocarbon and aldehyde emissions below 10 ppM were achieved with 5% excess oxygen and 1,200{degrees}C average temperature for aspen flakeboard and 1,100{degrees}C for clean aspen at a 0.9 s residence time. When the average temperature decreased below these levels, the emissions increased rapidly. For example, at 950{degrees}C and 5% excess oxygen the formaldehyde emissions were over 1,000 ppM. These laboratory tests reinforce the need to carefully control the temperature and excess oxygen in full-scale wood combustors.

  10. Health informatics to optimize complex laboratory developed test configurations.

    PubMed

    Afzal, Uzma; Mahmood, Tariq; Anwar, Masood; Shaikh, Zubair

    2016-11-14

    Configuration of complex Laboratory Developed Tests (LDTs) is a time-consuming and complicated task, potentially leading to inconsistent LDTs in which features constraints remain unresolved and important features could remain unselected. Our objective is to address these issues by presenting an automated, health informatics solution which autonomously optimizes feature selection in complex LDTs through Particle Swarm Optimization (PSO). The optimization goal is to minimize inconsistencies and configuration time, and maximize the number of selected features. We implemented our technology in a local, secondary-care hospital in Pakistan which configures LDT for a local epidemic disease. First, a list of inconsistent LDT configurations is generated. This is used to initially estimate optimal PSO parameters, which are then used for optimization process. Results show that PSO is able to minimize 91% inconsistencies between 9 and 11 seconds. The number of selected critical features also increases by 100% in the optimized LDT configuration. We present a novel and the first application of computational optimization to solve LDT configuration issues.

  11. Brookhaven National Laboratory's Accelerator Test Facility: research highlights and plans

    NASA Astrophysics Data System (ADS)

    Pogorelsky, I. V.; Ben-Zvi, I.

    2014-08-01

    The Accelerator Test Facility (ATF) at Brookhaven National Laboratory has served as a user facility for accelerator science for over a quarter of a century. In fulfilling this mission, the ATF offers the unique combination of a high-brightness 80 MeV electron beam that is synchronized to a 1 TW picosecond CO2 laser. We unveil herein our plan to considerably expand the ATF's floor space with an upgrade of the electron beam's energy to 300 MeV and the CO2 laser's peak power to 100 TW. This upgrade will propel the ATF even further to the forefront of research on advanced accelerators and radiation sources, supporting the most innovative ideas in this field. We discuss emerging opportunities for scientific breakthroughs, including the following: plasma wakefield acceleration studies in research directions already active at the ATF; laser wakefield acceleration (LWFA), where the longer laser wavelengths are expected to engender a proportional increase in the beam's charge while our linac will assure, for the first time, the opportunity to undertake detailed studies of seeding and staging of the LWFA; proton acceleration to the 100-200 MeV level, which is essential for medical applications; and others.

  12. Multi-Sensor Testing for Automated Rendezvous and Docking Sensor Testing at the Flight Robotics Laboratory

    NASA Technical Reports Server (NTRS)

    Brewster, L.; Johnston, A.; Howard, R.; Mitchell, J.; Cryan, S.

    2007-01-01

    The Exploration Systems Architecture defines missions that require rendezvous, proximity operations, and docking (RPOD) of two spacecraft both in Low Earth Orbit (LEO) and in Low Lunar Orbit (LLO). Uncrewed spacecraft must perform automated and/or autonomous rendezvous, proximity operations and docking operations (commonly known as AR&D). The crewed missions may also perform rendezvous and docking operations and may require different levels of automation and/or autonomy, and must provide the crew with relative navigation information for manual piloting. The capabilities of the RPOD sensors are critical to the success of the Exploration Program. NASA has the responsibility to determine whether the Crew Exploration Vehicle (CEV) contractor proposed relative navigation sensor suite will meet the requirements. The relatively low technology readiness level of AR&D relative navigation sensors has been carried as one of the CEV Project's top risks. The AR&D Sensor Technology Project seeks to reduce the risk by the testing and analysis of selected relative navigation sensor technologies through hardware-in-the-loop testing and simulation. These activities will provide the CEV Project information to assess the relative navigation sensors maturity as well as demonstrate test methods and capabilities. The first year of this project focused on a series of"pathfinder" testing tasks to develop the test plans, test facility requirements, trajectories, math model architecture, simulation platform, and processes that will be used to evaluate the Contractor-proposed sensors. Four candidate sensors were used in the first phase of the testing. The second phase of testing used four sensors simultaneously: two Marshall Space Flight Center (MSFC) Advanced Video Guidance Sensors (AVGS), a laser-based video sensor that uses retroreflectors attached to the target vehicle, and two commercial laser range finders. The multi-sensor testing was conducted at MSFC's Flight Robotics Laboratory (FRL

  13. Multi-Sensor Testing for Automated Rendezvous and Docking Sensor Testing at the Flight Robotics Laboratory

    NASA Technical Reports Server (NTRS)

    Brewster, L.; Johnston, A.; Howard, R.; Mitchell, J.; Cryan, S.

    2007-01-01

    The Exploration Systems Architecture defines missions that require rendezvous, proximity operations, and docking (RPOD) of two spacecraft both in Low Earth Orbit (LEO) and in Low Lunar Orbit (LLO). Uncrewed spacecraft must perform automated and/or autonomous rendezvous, proximity operations and docking operations (commonly known as AR&D). The crewed missions may also perform rendezvous and docking operations and may require different levels of automation and/or autonomy, and must provide the crew with relative navigation information for manual piloting. The capabilities of the RPOD sensors are critical to the success of the Exploration Program. NASA has the responsibility to determine whether the Crew Exploration Vehicle (CEV) contractor proposed relative navigation sensor suite will meet the requirements. The relatively low technology readiness level of AR&D relative navigation sensors has been carried as one of the CEV Project's top risks. The AR&D Sensor Technology Project seeks to reduce the risk by the testing and analysis of selected relative navigation sensor technologies through hardware-in-the-loop testing and simulation. These activities will provide the CEV Project information to assess the relative navigation sensors maturity as well as demonstrate test methods and capabilities. The first year of this project focused on a series of"pathfinder" testing tasks to develop the test plans, test facility requirements, trajectories, math model architecture, simulation platform, and processes that will be used to evaluate the Contractor-proposed sensors. Four candidate sensors were used in the first phase of the testing. The second phase of testing used four sensors simultaneously: two Marshall Space Flight Center (MSFC) Advanced Video Guidance Sensors (AVGS), a laser-based video sensor that uses retroreflectors attached to the target vehicle, and two commercial laser range finders. The multi-sensor testing was conducted at MSFC's Flight Robotics Laboratory (FRL

  14. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... laboratory facilities capable of performing such work are not available, or because of location or for other reasons it is clearly impractical to utilize such private commerical laboratory services. The requesting entity must further certify that such services cannot be procured reasonably and expeditiously...

  15. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... laboratory facilities capable of performing such work are not available, or because of location or for other reasons it is clearly impractical to utilize such private commerical laboratory services. The requesting entity must further certify that such services cannot be procured reasonably and expeditiously...

  16. Test plan: Laboratory-scale testing of the first core sample from Tank 102-AZ

    SciTech Connect

    Morrey, E.V.

    1996-03-01

    The overall objectives of the Radioactive Process/Product Laboratory Testing (RPPLT), WBS 1.2.2.05.05, are to confirm that simulated HWVP feed and glass are representative of actual radioactive HWVP feed and glass and to provide radioactive leaching and glass composition data to WFQ. This study will provide data from one additional NCAW core sample (102-AZ Core 1) for these purposes.

  17. 7. Exterior view of Components Test Laboratory (T27), looking south. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Exterior view of Components Test Laboratory (T-27), looking south. The wing in the immediate foreground houses the equipment room. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  18. 75 FR 9953 - Definition and Requirements for a Nationally Recognized Testing Laboratory (NRTL); Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Laboratory (NRTL); Extension of the Office of Management and Budget's (OMB) Approval of Information... Nationally Recognized Testing Laboratory (29 CFR 1910.7). The Regulation specifies procedures that... nationally recognized testing laboratory (NRTL); this requirement ensures that employers use safe and...

  19. 10 CFR 26.153 - Using certified laboratories for testing urine specimens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 26.153 Section 26.153 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Laboratories... initial and confirmatory tests for specimen validity and for each drug and drug metabolite for which the... laboratory; (3) The laboratory shall maintain test records in confidence, consistent with the requirements...

  20. Recommended procedures for performance testing of radiobioassay laboratories: Volume 2, In vitro samples

    SciTech Connect

    Fenrick, H.W.; MacLellan, J.A.

    1988-11-01

    Draft American National Standards Institute (ANSI) Standard N13.30 (Performance Criteria for Radiobioassay) was developed for the US Department of Energy and the US Nuclear Regulatory Commission to help ensure that bioassay laboratories provide accurate and consistent results. The draft standard specifies the criteria for defining the procedures necessary to establish a bioassay performance-testing laboratory and program. The bioassay testing laboratory will conduct tests to evaluate the performance of service laboratories. Pacific Northwest Laboratory helped develop testing procedures as part of an effort to evaluate the performance criteria by testing the existing measurement capabilities of various bioassay laboratories. This report recommends guidelines for the preparation, handling, storage, distribution, shipping, and documentation of in vitro test samples (artificial urine and fecal matter) for indirect bioassay. The data base and recommended records system for documenting radiobioassay performance at the service laboratories are also presented. 8 refs., 3 tabs.

  1. Syphilis testing in antenatal care: Policies and practices among laboratories in the Americas.

    PubMed

    Luu, Minh; Ham, Cal; Kamb, Mary L; Caffe, Sonja; Hoover, Karen W; Perez, Freddy

    2015-06-01

    To asses laboratory syphilis testing policies and practices among laboratories in the Americas. Laboratory directors or designees from PAHO member countries were invited to participate in a structured, electronically-delivered survey between March and August, 2014. Data on syphilis tests, algorithms, and quality control (QC) practices were analyzed, focusing on laboratories receiving specimens from antenatal clinics (ANCs). Surveys were completed by 69 laboratories representing 30 (86%) countries. Participating laboratories included 36 (52%) national or regional reference labs and 33 (48%) lower-level laboratories. Most (94%) were public sector facilities and 71% reported existence of a national algorithm for syphilis testing in pregnancy, usually involving both treponemal and non-treponemal testing (72%). Less than half (41%) used rapid syphilis tests (RSTs); and only seven laboratories representing five countries reported RSTs were included in the national algorithm for pregnant women. Most (83%) laboratories serving ANCs reported using some type of QC system; 68% of laboratories reported participation in external QC. Only 36% of laboratories reported data to national/local surveillance. Half of all laboratories serving ANC settings reported a stockout of one or more essential supplies during the previous year (median duration, 30days). Updating laboratory algorithms, improving testing standards, integrating data into existing surveillance, and improved procurement and distribution of commodities may be needed to ensure elimination of MTCT of syphilis in the Americas. Copyright © 2015. Published by Elsevier Ireland Ltd.

  2. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY ADMINISTRATION...

  3. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL SECURITY...

  4. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY ADMINISTRATION...

  5. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY ADMINISTRATION...

  6. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL SECURITY...

  7. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL SECURITY...

  8. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY ADMINISTRATION...

  9. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY ADMINISTRATION...

  10. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL SECURITY...

  11. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL SECURITY...

  12. Standards for thyroid laboratory testing, and cognitive functions after menopause

    PubMed Central

    Bejga, Przemysław; Witczak, Mariusz; Łyszcz, Robert; Makara-Studzinska, Marta

    2014-01-01

    Introduction The aim of the study is to analyze the relationship between normative and non-normative thyroid tests (TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR) and the level of cognitive functions in postmenopausal women. Material and methods The study group consisted of 383 women from south-eastern Poland, aged 50-65 years. The cognitive functions were evaluated using a diagnostic instrument – Central Nervous System – Vital Signs (CNS-VS). Blood was collected for determination of the following parameters: TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR. Results There were significant differences in NCI, executive functions, psychomotor speed, reaction time, complex attention and cognitive flexibility, depending on the normative and non-normative level of TSH. Women whose level of FT3 was at the lower limit of the normal range obtained poorer results in psychomotor speed, while subjects with levels of FT4 below the standard achieved significantly lower scores for this function. The relationship between NCI and cognitive functions, and the normative and non-normative anti-TPO results, showed significant differences in verbal memory, visual memory, processing speed and reaction time. The level of AB-TSHR reported as normal or above the norm significantly differentiated from the results of NCI, processing speed, executive functions, psychomotor speed, complex attention and cognitive flexibility. Conclusions Concentrations of laboratory parameters assessing the thyroid function located within the upper limits of the normal range showed a different relationship with the cognitive performance than concentrations located within the lower limits of the standard. PMID:26327860

  13. 78 FR 59946 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories certified through...

  14. 77 FR 32653 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Council of Canada (SCC) voted to end its Laboratory Accreditation Program for Substance Abuse...

  15. 78 FR 72684 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... its Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998....

  16. 77 FR 69642 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... its Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998....

  17. 76 FR 11802 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... its Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998....

  18. 78 FR 7795 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Standards Council of Canada (SCC) voted to end its Laboratory Accreditation Program for Substance...

  19. 77 FR 126 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories certified through that...

  20. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... diagnostic tests—(1) Basic rule. Except as indicated in paragraph (b)(2) of this section, all diagnostic x... diagnostic tests payable under the physician fee schedule are excluded from the basic rule set forth in..., osteopathy, podiatric medicine, dental surgery, or dental medicine. (iv) An RHC. (v) A laboratory, if...

  1. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... diagnostic tests—(1) Basic rule. Except as indicated in paragraph (b)(2) of this section, all diagnostic x... diagnostic tests payable under the physician fee schedule are excluded from the basic rule set forth in..., osteopathy, podiatric medicine, dental surgery, or dental medicine. (iv) An RHC. (v) A laboratory, if...

  2. Settling velocity of marine microplastic particles: laboratory tests

    NASA Astrophysics Data System (ADS)

    Isachenko, Igor; Khatmullina, Lilia; Chubarenko, Irina; Stepanova, Natalia

    2016-04-01

    An assessment of the settling velocity of different classes of microplastic particles (< 5 mm) is crucial for the prediction of their transport and fate. The Reynolds numbers for the settling microplastic particles is usually outside the Stokes range (Re << 1), but still far from fully developed turbulent flow (Re >105). Even for such transitional regime, the settling velocity of the particles that could be treated as more or less smooth spheres can be predicted with high accuracy by relationships available in publications. This is not the case for the non-spherical particles like fibres or flakes. There are quite a large number of quasi-theoretical or semi-empirical approaches that take into account the shape and roughness of the particles, usually in the applications to transport of natural sediments. Some engineering formulas for the settling velocity are also developed which have simpler structure along with high degree of accuracy on the set of experimental data. For marine microplastic particles, the absence of relationship between the settling velocity and the properties of the particle requires testing on the samples of marine microplastics. Besides small fragments of rigid plastic (granules, microbeads), there are also fibres and thin plastic sheets (flakes) with some degree of flexibility. The applicability of available formulae to thin and/or flexible plastic particles again requires verification by experiments. The set of laboratory experiments on settling of microplastic particles of various shapes and excess densities in homogeneous water is reported. The particles were collected in water column, bottom sediments and on the beaches of the South-Eastern Baltic. The experiments demonstrate not just different regimes of motion but different manner of the sinking of spheres, flakes and fibres. The very definition of the "settling velocity" has a specific meaning for every kind of a particle shape. The results of test measurements are compared with

  3. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... applies to Corps of Engineers Divisions and Districts operating soils, concrete, water quality and... will directly contribute to a specific planning, design, or construction activity which derives its... Project, St. Anthony Falls Laboratory, University of Minnesota, Minneapolis, Minnesota. The District...

  4. Results of Laboratory Testing of Advanced Power Strips: Preprint

    SciTech Connect

    Earle, L.; Sparn, B.

    2012-08-01

    This paper describes the results of a laboratory investigation to evaluate the technical performance of advanced power strip (APS) devices when subjected to a range of home entertainment center and home office usage scenarios.

  5. Predicting oxygenator clinical performance from laboratory in-vitro testing.

    PubMed

    Griffith, K E; Vasquez, M R; Beckley, P D; LaLone, B J

    1994-09-01

    Knowledge and predictability of oxygenator performance is vital to safe and effective conduct of cardiopulmonary bypass. The determination of oxygenator performance in the laboratory, however, is carried out under a strict set of conditions established by the Association for the Advancement of Medical Instrumentation (AAMI). This performance data is of limited value in the clinical setting where the perfusionist generally operates outside this set of parameters. This study (1) reports the laboratory performance characteristics of a hollow fiber membrane oxygenator (Sorin Monolyth), (2) uses this data to develop a model to predict performance under a wide range of clinical conditions, (3) compares predicted performance with clinical data collected at two open heart centers, and (4) reviews the complexities of comparing laboratory and clinical performance. An in-vitro "oxygenator-deoxygenator" circuit was utilized to determine O2 and CO2 gas exchange, blood path pressure drop, and heat exchanger efficiency at a variety of blood and gas flows, under standard (AAMI) blood inlet conditions: [table: see text] This laboratory performance data was compared to hospital and computer modeling data. Simple numerical comparison and analysis of variance of regression coefficients over groups indicated that some clinical parameters of performance (oxygen transfer and coefficient of heat exchange) were not predicted with the laboratory data. It is concluded that the laboratory performance data determined under strict controlled conditions may be of limited value in predicting clinical performance unless modeled to allow for variances in operating conditions.

  6. Laboratory testing during critical care transport: point-of-care testing in air ambulances.

    PubMed

    Di Serio, Francesca; Petronelli, Maria Antonia; Sammartino, Eugenio

    2010-07-01

    Air and ground transport are used for prehospital transport of patients in acute life-threatening situations, and increasingly, critically ill patients undergo interhospital transportation. Results from clinical studies suggest that critical tests performed during the transport of critically ill patients presents a potential opportunity to improve patient care. Our project was to identify, according to the recommendations published at this time, a model of point-of-care testing (POCT) (arterial blood gases analysis and glucose, sodium, potassium, ionized calcium, hematocrit/hemoglobin measurements) in air ambulances. In order to identify the key internal and external factors that are important to achieving our objective, an analysis of the Strengths, Weaknesses, Opportunities, and Threats (SWOT analysis) was incorporated into our planning model prior to starting the project. To allow the entire POCT process (pre-, intra-, and post-analytic steps) to be under the control of the reference laboratory, an experimental model of information technology was applied. Real-time results during transport of critically ill patients must be considered to be an integral part of the patient care process and excellent channels of communication are needed between the intensive care units, emergency medical services and laboratories. With technological and computer advances, POCT during critical care transport will certainly increase in the future: this will be a challenge from a laboratory and clinical context.

  7. Clinical laboratory testing: what is the role of tilt-table testing, active standing test, carotid massage, electrophysiological testing and ATP test in the syncope evaluation?

    PubMed

    Blanc, Jean-Jacques

    2013-01-01

    The first step in the diagnostic evaluation of patients with suspected syncope begins with an "initial evaluation" consisting of careful history taking, physical examination including orthostatic blood pressure measurement and electrocardiogram. However, even in expert centers the diagnostic yield of this "initial evaluation" is only approximately 50%. In the remaining cases in which a satisfactory diagnosis is either unknown or uncertain after initial assessment, additional clinical testing is needed. This article reviews the role of some of the more commonly used additional diagnostic tests, including: tilt-table testing, the active standing test, carotid sinus massage, electrophysiological testing, and the adenosine triphosphate (ATP) test. The role of angiography, exercise testing and imaging is noted briefly. Other clinical laboratory investigations, such as ambulatory ECG monitoring, are examined in other papers in this issue. In brief, clinical laboratory tests, carefully interpreted, may be useful in the evaluation of the basis of suspected syncope. However, these tests should be selected carefully and performed based on the pre-test probability inferred from the initial examination, and the less invasive tests should be used first. Copyright © 2013. Published by Elsevier Inc.

  8. Development of New, Low-Head Hydropower Turbine - Modeling & Laboratory Test DE-EE0005426

    SciTech Connect

    Krouse, Wayne

    2014-12-05

    Hydro Green Energy, LLC (HGE) will complete the design, fabrication and laboratory testing of a scaled, vertically stackable, low-head hydropower turbine called the Modular Bulb Turbine (MBT). HGE will also complete a summary report that includes the laboratory testing results and analysis of the tests. Project Goals: Design, model and test modular bulb turbine for installation in numerous HGE low-head hydropower projects at non-powered USACE dams. Project Results: The sub-scale prototype was tested successfully at a leading US hydraulic laboratory. Laboratory data results agreed well with predicted results from numerical modeling.

  9. The brain-to-brain loop concept for laboratory testing 40 years after its introduction.

    PubMed

    Plebani, Mario; Laposata, Michael; Lundberg, George D

    2011-12-01

    Forty years ago, Lundberg introduced the concept of the brain-to-brain loop for laboratory testing. In this concept, in the brain of the physician caring for the patient, the first step involves the selection of laboratory tests and the final step is the transmission of the test result to the ordering physician. There are many intermediary steps, some of which are preanalytic, ie, before performance of the test; some are analytic and relate to the actual performance of the test; and others are postanalytic and involve transmission of test results into the medical record. The introduction of this concept led to a system to identify and classify errors associated with laboratory test performance. Errors have since been considered as preanalytic, analytic, and postanalytic. During the past 4 decades, changes in medical practice have significantly altered the brain-to-brain loop for laboratory testing. This review describes the changes and their implications for analysis of errors associated with laboratory testing.

  10. Good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders.

    PubMed

    2012-04-06

    Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. Under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations, laboratory testing is categorized on the basis of the level of testing complexity as either waived (i.e., from routine regulatory oversight) or nonwaived testing (which includes tests of moderate and high complexity). Laboratories that perform biochemical genetic testing are required by CLIA regulations to meet the general quality systems requirements for nonwaived testing and the personnel requirements for high-complexity testing. Laboratories that perform public health newborn screening are subject to the same CLIA regulations and applicable state requirements. As the number of inherited metabolic diseases that are included in state-based newborn screening programs continues to increase, ensuring the quality of performance and delivery of testing services remains a continuous challenge not only for public health laboratories and other newborn screening facilities but also for biochemical genetic testing laboratories. To help ensure the quality of laboratory testing, CDC collaborated with the Centers for Medicare & Medicaid Services, the Food and Drug Administration, the Health Resources and Services Administration, and the National Institutes of Health to develop guidelines for laboratories to meet CLIA requirements and apply additional quality assurance measures for these areas of genetic testing. This report provides recommendations for good laboratory practices that were developed based on recommendations from the Clinical Laboratory Improvement Advisory Committee, with additional input from the Secretary's Advisory Committee on Genetics, Health, and Society; the Secretary's Advisory Committee on Heritable Disorders in Newborns and Children; and representatives of newborn

  11. Testing of the Semikron Validation AIPM Unit at Oak Ridge National Laboratory -- October 2004

    SciTech Connect

    Nelson, S.C.

    2004-11-12

    This report documents the electrical tests performed on the Semikron high-voltage automotive integrated power module (AIPM) at Oak Ridge National Laboratory (ORNL). Testing was performed in the 100-hp dynamometer test cell at the National Transportation Research Center.

  12. The national market for Medicare clinical laboratory testing: implications for payment reform.

    PubMed

    Gass Kandilov, Amy M; Pope, Gregory C; Kautter, John; Healy, Deborah

    2012-01-01

    Current Medicare payment policy for outpatient laboratory services is outdated. Future reforms, such as competitive bidding, should consider the characteristics of the laboratory market. To inform payment policy, we analyzed the structure of the national market for Medicare Part B clinical laboratory testing, using a 5-percent sample of 2006 Medicare claims data. The independent laboratory market is dominated by two firms--Quest Diagnostics and Laboratory Corporation of America. The hospital outreach market is not as concentrated as the independent laboratory market. Two subgroups of Medicare beneficiaries, those with end-stage renal disease and those residing in nursing homes, are each served in separate laboratory markets. Despite the concentrated independent laboratory market structure, national competitive bidding for non-patient laboratory tests could result in cost savings for Medicare.

  13. PEP Support Laboratory Leaching and Permeate Stability Tests

    SciTech Connect

    Russell, Renee L.; Peterson, Reid A.; Rinehart, Donald E.; Buchmiller, William C.

    2009-09-25

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed, and operated as part of a plan to respond to issue M12, "Undemonstrated Leaching Processes," of the External Flowsheet Review Team (EFRT) issue response plan.( ) The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. A simplified flow diagram of the PEP system is shown in Figure 1.1. Two operating scenarios are currently being evaluated for the ultrafiltration process (UFP) and leaching operations. The first scenario has caustic leaching performed in the UFP-2 ultrafiltration feed vessels (i.e., vessel UFP-VSL-T02A in the PEP and vessels UFP-VSL-00002A and B in the WTP PTF). The second scenario has caustic leaching conducted in the UFP-1 ultrafiltration feed preparation vessels (i.e., vessels UFP-VSL-T01A and B in the PEP and vessels UFP-VSL-00001A and B in the WTP PTF). In both scenarios, 19-M sodium hydroxide solution (NaOH, caustic) is added to the waste slurry in the vessels to leach solid aluminum compounds (e.g., gibbsite, boehmite). Caustic addition is followed by a heating step that uses direct injection of steam to accelerate the leach process. Following the caustic leach, the vessel contents are cooled using vessel cooling jackets and/or external heat exchangers. The main difference between the two scenarios is that for leaching in UFP-VSL-T01A and B, the 19-M NaOH is added to un-concentrated waste slurry (3 to 8 wt% solids), while for leaching in

  14. Trends in Testing for Mycobacterium tuberculosis Complex From US Public Health Laboratories, 2009-2013.

    PubMed

    Tyrrell, Frances; Stafford, Cortney; Yakrus, Mitchell; Youngblood, Monica; Hill, Andrew; Johnston, Stephanie

    We investigated data from US public health laboratories funded through the Centers for Disease Control and Prevention's Tuberculosis Elimination and Laboratory Cooperative Agreement to document trends and challenges in meeting national objectives in tuberculosis (TB) laboratory diagnoses. We examined data on workload and turnaround time from public health laboratories' progress reports during 2009-2013. We reviewed methodologies, laboratory roles, and progress toward rapid detection of Mycobacterium tuberculosis complex through nucleic acid amplification (NAA) testing. We compared selected data with TB surveillance reports to estimate public health laboratories' contribution to national diagnostic services. During the study period, culture and drug susceptibility tests decreased, but NAA testing increased. Public health laboratories achieved turnaround time benchmarks for drug susceptibility tests at lower levels than for acid-fast bacilli smear and identification from culture. NAA positivity in laboratories among surveillance-reported culture-positive TB cases increased from 26.6% (2355 of 8876) in 2009 to 40.0% (2948 of 7358) in 2013. Public health laboratories provided an estimated 50.9% (4285 of 8413 in 2010) to 57.2% (4210 of 7358 in 2013) of culture testing and 88.3% (6822 of 7727 in 2011) to 94.4% (6845 of 7250 in 2012) of drug susceptibility tests for all US TB cases. Public health laboratories contribute substantially to TB diagnoses in the United States. Although testing volumes mostly decreased, the increase in NAA testing indicates continued progress in rapid M tuberculosis complex detection.

  15. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  16. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  17. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  18. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  19. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  20. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  1. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  2. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  3. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  4. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the apparatus...

  5. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the apparatus...

  6. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... conducting such tests or analyses. The owner or operator must also submit all data collected during the field... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to...

  7. King County Metro Transit: Allison Hybrid Electric Transit Bus Laboratory Testing

    SciTech Connect

    Hayes, R. R.; Williams, A.; Ireland, J.; Walkowicz, K.

    2006-09-01

    Paper summarizes chassis dynamometer testing of two 60-foot articulated transit buses, one conventional and one hybrid, at NREL's ReFUEL Laboratory. It includes experimental setup, test procedures, and results from vehicle testing performed at the NREL ReFUEL laboratory.

  8. An Alternative to the Physiological Psychology Laboratory: Identification of an Unknown Drug Through Behavioral Testing.

    ERIC Educational Resources Information Center

    Schumacher, Susan J.

    1982-01-01

    A laboratory project introduced physiological psychology students to research by requiring them to identify an unknown drug given to laboratory animals. Students read material about drugs and animal drug studies, designed behavioral tests, constructed the testing apparatus, conducted the tests, and wrote progress reports. (SR)

  9. Testing painted wood : past practices at the Forest Products Laboratory and recommendations for future research

    Treesearch

    R. Sam Williams

    2009-01-01

    A brief history of paint research at the Forest Products Laboratory (FPL) in Madison, Wisconsin, sets the stage for a discussion of testing paint on wood and wood products. Tests include laboratory and outdoor tests, and I discuss them in terms of several degradation mechanisms (loss of gloss and fading, mildew growth, extractives bleed, and cracking, flaking, and...

  10. 42 CFR 493.20 - Laboratories performing tests of moderate complexity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... complexity. 493.20 Section 493.20 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Provisions § 493.20 Laboratories performing tests of moderate complexity. (a) A laboratory may qualify for a certificate to perform tests of moderate complexity provided that it restricts its test performance to waived...

  11. An Alternative to the Physiological Psychology Laboratory: Identification of an Unknown Drug Through Behavioral Testing.

    ERIC Educational Resources Information Center

    Schumacher, Susan J.

    1982-01-01

    A laboratory project introduced physiological psychology students to research by requiring them to identify an unknown drug given to laboratory animals. Students read material about drugs and animal drug studies, designed behavioral tests, constructed the testing apparatus, conducted the tests, and wrote progress reports. (SR)

  12. Proficiency testing. Its role in a voluntary clinical Laboratory Accreditation Program.

    PubMed

    Duckworth, J K

    1988-04-01

    The author's long experience as Chairman of the Laboratory Accreditation Program of the College of American Pathologists provides the background for this article. Laboratory accreditation and proficiency testing have now become an established part of the clinical laboratories in the United States. This article attempts to demonstrate the relationship between proficiency testing and accreditation, and highlights some of the current problems and future challenges facing proficiency testing as pertains to accreditation.

  13. Use of laboratory test results in patient management by clinicians in Malawi

    PubMed Central

    Moyo, Kundai; Porter, Carol; Chilima, Ben; Mwenda, Reuben; Kabue, Mark; Zungu, Lutho; Sarr, Abdoulaye

    2016-01-01

    Background Malawi has a high burden of infectious disease. The expansion of programmes targeting these diseases requires a strong laboratory infrastructure to support both diagnosis and treatment. Objectives To assess the use of laboratory test results in patient management and to determine the requirements for improving laboratory services. Methods A cross-sectional study was conducted in 2012 to survey practising clinicians. Two hospitals were purposively selected for observations of clinicians ordering laboratory tests. Twelve management-level key informants were interviewed. Descriptive statistics were conducted. Results A total of 242 clinicians were identified and 216 (89%) were interviewed. Of these, 189 (87%) reported doubting laboratory test results at some point. Clinicians most often doubted the quality of haematology (67%), followed by malaria (53%) and CD4 (22%) test results. A total of 151 (70%) clinicians reported using laboratory tests results in patient management. Use of laboratory test results at all times in patient management varied by the type of health facility (P < 0.001). Ninety-one percent of clinicians reported that laboratories required infrastructure improvement. During 97 observations of clinicians’ use of laboratory test results, 80 tests were ordered, and 73 (91%) of these were used in patient management. Key informants reported that the quality of laboratory services was good and useful, but that services were often unavailable. Conclusion Gaps in the public laboratory system were evident. Key recommendations to enhance the use of laboratory test results in patient management were to strengthen the supply chain, reduce turn-around times, improve the test menu and improve the laboratory infrastructure. PMID:27213139

  14. 9 CFR 55.8 - Official CWD tests and approval of laboratories to conduct official CWD tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... APHIS and, when appropriate, outside scientists, of: (1) A standardized test protocol that must include... determines that the laboratory: (1) Employs personnel assigned to supervise the testing who are qualified to...

  15. 9 CFR 55.8 - Official CWD tests and approval of laboratories to conduct official CWD tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... APHIS and, when appropriate, outside scientists, of: (1) A standardized test protocol that must include... determines that the laboratory: (1) Employs personnel assigned to supervise the testing who are qualified to...

  16. 9 CFR 55.8 - Official CWD tests and approval of laboratories to conduct official CWD tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... APHIS and, when appropriate, outside scientists, of: (1) A standardized test protocol that must include... determines that the laboratory: (1) Employs personnel assigned to supervise the testing who are qualified to...

  17. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... hydraulic laboratories, and to the Inter-Agency Sedimentation Project. (c) References. (1) AR 37-20. (2) AR... units of government, foreign governments and private firms under the following conditions: (1) The work will be performed on a cost reimbursable basis. (2) Work may be performed for State and local units...

  18. Nucleic acid testing by public health referral laboratories for public health laboratories using the U.S. HIV diagnostic testing algorithm.

    PubMed

    Wesolowski, Laura G; Wroblewski, Kelly; Bennett, Spencer B; Parker, Monica M; Hagan, Celia; Ethridge, Steven F; Rhodes, Jeselyn; Sullivan, Timothy J; Ignacio-Hernando, Imelda; Werner, Barbara G; Owen, S Michele

    2015-04-01

    Many public health laboratories adopting the U.S. HIV laboratory testing algorithm do not have a nucleic acid test (NAT), which is needed when the third- or fourth-generation HIV screening immunoassay is reactive and the antibody-based supplemental test is non-reactive or indeterminate. Among public health laboratories utilizing public health referral laboratories for NAT conducted as part of the algorithm, we evaluated the percentage of screening immunoassays needing NAT, the number of specimens not meeting APTIMA (NAT) specifications, time to APTIMA result, the proportion of acute infections (i.e., reactive APTIMA) among total infections, and screening immunoassay specificity. From August 2012 to April 2013, 22 laboratories enrolled to receive free APTIMA (NAT) at New York or Florida public health referral laboratories. Data were analyzed for testing conducted until June 2013. Submitting laboratories conducted a median of 4778 screening immunoassays; 0-1.3% (median 0.2%) needed NAT. Of 140 specimens received, 9 (6.4%) did not meet NAT specifications. The median time from specimen collection to reporting the 11 reactive NAT results was ten days, including six days from receipt in the submitting laboratory to shipment to the referral laboratory. Acute infections ranged from 0 to 12.5% (median 0%) of total infections. Third- and fourth-generation immunoassays met package insert specificity values. Public health referral laboratories provide a feasible option for conducting NAT. Reducing the time from specimen collection to submission of specimens for NAT is an important step toward maximizing the public health impact of identifying acute infections. Published by Elsevier B.V.

  19. Draft Test Guideline: Special Considerations for Conducting Aquatic Laboratory Studies

    EPA Pesticide Factsheets

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  20. 49 CFR Appendix B to Part 219 - Designation of Laboratory for Post-Accident Toxicological Testing

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Designation of Laboratory for Post-Accident.... 219, App. B Appendix B to Part 219—Designation of Laboratory for Post-Accident Toxicological Testing The following laboratory is currently designated to conduct post-accident toxicological analysis...

  1. 49 CFR Appendix B to Part 219 - Designation of Laboratory for Post-Accident Toxicological Testing

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Designation of Laboratory for Post-Accident.... 219, App. B Appendix B to Part 219—Designation of Laboratory for Post-Accident Toxicological Testing The following laboratory is currently designated to conduct post-accident toxicological analysis...

  2. 49 CFR Appendix B to Part 219 - Designation of Laboratory for Post-Accident Toxicological Testing

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Designation of Laboratory for Post-Accident.... 219, App. B Appendix B to Part 219—Designation of Laboratory for Post-Accident Toxicological Testing The following laboratory is currently designated to conduct post-accident toxicological analysis...

  3. 77 FR 45645 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ...: Forensic Toxicology Laboratory Baptist Medical Center). Clinical Reference Lab, 8433 Quivira Road, Lenexa... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...-882-1273. U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson Street, Fort George G...

  4. 77 FR 5037 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ..., (Formerly: Forensic Toxicology Laboratory Baptist Medical Center); Clinical Reference Lab, 8433 Quivira Road... Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725-2088..., FL 33166, 305-593-2260; U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St., Fort...

  5. 76 FR 61110 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ...-202-2783. (Formerly: Forensic Toxicology Laboratory Baptist Medical Center.) Clinical Reference Lab... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725...., Miami, FL 33166, 305-593-2260. U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St...

  6. 76 FR 46309 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ...-202-2783 (Formerly: Forensic Toxicology Laboratory Baptist Medical Center) Clinical Reference Lab... Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725... 33166, 305-593-2260 U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St., Fort George...

  7. 76 FR 31969 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... 72209-7056, 501-202-2783, (Formerly: Forensic Toxicology Laboratory Baptist Medical Center). Clinical... Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN 55417, 612-725-2088...., Miami, FL 33166, 305-593-2260. U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St...

  8. 76 FR 6147 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... Laboratory, 11401 I-30, Little Rock, AR 72209-7056. 501-202-2783. (Formerly: Forensic Toxicology Laboratory.... Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN... Testing Service, Inc., 5426 NW. 79th Ave., Miami, FL 33166. 305-593-2260. U.S. Army Forensic Toxicology...

  9. Tried and True: Tested Ideas for Teaching and Learning from the Regional Educational Laboratories.

    ERIC Educational Resources Information Center

    Levinson, Luna; Stonehill, Robert

    This collection of 16 tested ideas for improving teaching and learning evolved from the work of the 1995 Proven Laboratory Practices Task Force charged with identifying and collecting the best and most useful work from the Regional Educational Laboratories. The Regional Educational Laboratory program is the largest research and development…

  10. Audio Development Laboratory (ADL) User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Romero, Andy

    2012-01-01

    Test process, milestones and inputs are unknowns to first-time users of the ADL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  11. Sandia National Laboratories Electrochemical Storage System Abuse Test Procedure Manual

    SciTech Connect

    Unkelhaeuser, Terry; Smallwood David

    1999-07-01

    The series of tests described in this report are intended to simulate actual use and abuse conditions and internally initiated failures that may be experienced in electrochemical storage systems (ECSS). These tests were derived from Failure Mode and Effect Analysis, user input, and historical abuse testing. The tests are to provide a common framework for various ECSS technologies. The primary purpose of testing is to gather response information to external/internal inputs. Some tests and/or measurements may not be required for some ECSS technologies and designs if it is demonstrated that a test is not applicable, and the measurements yield no useful information.

  12. Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines.

    PubMed

    Kim, Sollip; Yun, Yeo Min; Chae, Hyo Jin; Cho, Hyun Jung; Ji, Misuk; Kim, In Suk; Wee, Kyung A; Lee, Woochang; Song, Sang Hoon; Woo, Hye In; Lee, Soo Youn; Chun, Sail

    2017-03-01

    Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetic testing covered by public medical insurance in Korea. This document aims to improve the utility of pharmacogenetic testing in routine clinical settings.

  13. Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines

    PubMed Central

    Kim, Sollip; Yun, Yeo-Min; Chae, Hyo-Jin; Cho, Hyun-Jung; Ji, Misuk; Kim, In-Suk; Wee, Kyung-A; Lee, Woochang; Song, Sang Hoon; Woo, Hye In

    2017-01-01

    Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetic testing covered by public medical insurance in Korea. This document aims to improve the utility of pharmacogenetic testing in routine clinical settings. PMID:28029011

  14. Determination of basic friction angle using various laboratory tests.

    NASA Astrophysics Data System (ADS)

    Jang, Bo-An

    2016-04-01

    The basic friction angle of rock is an important factor of joint shear strength and is included within most shear strength criteria. It can be measured by direct shear test, triaxial compression test and tilt test. Tilt test is mostly used because it is the simplest method. However, basic friction angles measured using tilt test for same rock type or for one sample are widely distributed and often do not show normal distribution. In this research, the basic friction angles for the Hangdeung granite form Korea and Berea sandstone from USA are measured accurately using direct shear test and triaxial compression test. Then basic friction angles are again measured using tilt tests with various conditions and are compared with those measured using direct shear test and triaxial compression test to determine the optimum condition of tilt test. Three types of sliding planes, such as planes cut by saw and planes polished by #100 and #600 grinding powders, are prepared. When planes are polished by #100 grinding powder, the basic friction angles measured using direct shear test and triaxial compression test are very consistent and show narrow ranges. However, basic friction angles show wide ranges when planes are cut by saw and are polished by #600 grinding powder. The basic friction angle measured using tilt test are very close to those measured using direct shear test and triaxial compression test when plane is polished by #100 grinding powder. When planes are cut by saw and are polished by #600 grinding powder, basic friction angles measured using tilt test are slightly different. This indicates that tilt test with plane polished by #100 grinding powder can yield an accurate basic friction angle. In addition, the accurate values are obtained not only when planes are polished again after 10 times of tilt test, but values are averaged by more 30 times of tests.

  15. The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis.

    PubMed

    Marra, Christina M; Tantalo, Lauren C; Maxwell, Clare L; Ho, Emily L; Sahi, Sharon K; Jones, Trudy

    2012-06-01

    The cerebrospinal fluid (CSF) Venereal Disease Research Laboratory (VDRL) test is a mainstay for neurosyphilis diagnosis, but it lacks diagnostic sensitivity and is logistically complicated. The rapid plasma reagin (RPR) test is easier to perform, but its appropriateness for use on CSF is controversial. RPR reactivity was determined for CSF from 149 individuals with syphilis using 2 methods. The CSF-RPR was performed according to the method for serum. The CSF-RPR-V was performed using the method recommended for the CSF-VDRL. Laboratory-defined neurosyphilis included reactive CSF-fluorescent treponemal antibody absorption test and CSF white blood cells >20/uL. Symptomatic neurosyphilis was defined as vision loss or hearing loss. CSF-VDRL was reactive in 45 (30.2%) patients. Of these, 29 (64.4%) were CSF-RPR reactive and 37 (82.2%) were CSF-RPR-V reactive. There were no instances where the CSF-VDRL was nonreactive but the CSF-RPR or CSF-RPR-V was reactive. Among the 28 samples that were reactive in all 3 tests, CSF-VDRL titers (median [IQR], 1:4 [1:4-1:16]) were significantly higher than CSF-RPR (1:2 [1:1-1:4], P = 0.0002) and CSF-RPR-V titers (1:4 [1:2-1:8], P = 0.01). The CSF RPR and the CSF-RPR-V tests had lower sensitivities than the CSF-VDRL: 56.4% and 59.0% versus 71.8% for laboratory-diagnosed neurosyphilis and 51.5% and 57.6% versus 66.7% for symptomatic neurosyphilis. Compared with the CSF-VDRL, the CSF-RPR has a high false-negative rate, thus not improving upon this known limitation of the CSF-VDRL for neurosyphilis diagnosis. Adapting the RPR procedure to mimic the CSF-VDRL decreased, but did not eliminate, the number of false negatives and did not avoid all the logistical complications of the CSF-VDRL.

  16. Effect of Accreditation on Accuracy of Diagnostic Tests in Medical Laboratories

    PubMed Central

    Jang, Mi-Ae; Yoon, Young Ahn; Song, Junghan; Kim, Jeong-Ho; Min, Won-Ki; Lee, Ji Sung

    2017-01-01

    Background Medical laboratories play a central role in health care. Many laboratories are taking a more focused and stringent approach to quality system management. In Korea, laboratory standardization efforts undertaken by the Korean Laboratory Accreditation Program (KLAP) and the Korean External Quality Assessment Scheme (KEQAS) may have facilitated an improvement in laboratory performance, but there are no fundamental studies demonstrating that laboratory standardization is effective. We analyzed the results of the KEQAS to identify significant differences between laboratories with or without KLAP and to determine the impact of laboratory standardization on the accuracy of diagnostic tests. Methods We analyzed KEQAS participant data on clinical chemistry tests such as albumin, ALT, AST, and glucose from 2010 to 2013. As a statistical parameter to assess performance bias between laboratories, we compared 4-yr variance index score (VIS) between the two groups with or without KLAP. Results Compared with the group without KLAP, the group with KLAP exhibited significantly lower geometric means of 4-yr VIS for all clinical chemistry tests (P<0.0001); this difference justified a high level of confidence in standardized services provided by accredited laboratories. Confidence intervals for the mean of each test in the two groups (accredited and non-accredited) did not overlap, suggesting that the means of the groups are significantly different. Conclusions These results confirmed that practice standardization is strongly associated with the accuracy of test results. Our study emphasizes the necessity of establishing a system for standardization of diagnostic testing. PMID:28224767

  17. Laboratory test and acoustic analysis of cabin treatment for propfan test assessment aircraft

    NASA Technical Reports Server (NTRS)

    Kuntz, H. L.; Gatineau, R. J.

    1991-01-01

    An aircraft cabin acoustic enclosure, built in support of the Propfan Test Assessment (PTA) program, is described. Helmholtz resonators were attached to the cabin trim panels to increase the sidewall transmission loss (TL). Resonators (448) were located between the trim panels and fuselage shell. In addition, 152 resonators were placed between the enclosure and aircraft floors. The 600 resonators were each tuned to a 235 Hz resonance frequency. After flight testing on the PTA aircraft, the enclosure was tested in the Kelly Johnson R and D Center Acoustics Lab. Laboratory noise reduction (NR) test results are discussed. The enclosure was placed in a Gulfstream 2 fuselage section. Broadband (138 dB overall SPL) and tonal (149 dB overall SPL) excitations were used in the lab. Tonal excitation simulated the propfan flight test excitation. The fundamental tone was stepped in 2 Hz intervals from 225 through 245 Hz. The resonators increase the NR of the cabin walls around the resonance frequency of the resonator array. The effects of flanking, sidewall absorption, cabin adsorption, resonator loading of trim panels, and panel vibrations are presented. Increases in NR of up to 11 dB were measured.

  18. Materials and Nondestructive Evaluation Laboratoriers: User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Schaschl, Leslie

    2011-01-01

    The Materials and Nondestructive Evaluation Laboratory process, milestones and inputs are unknowns to first-time users. The Materials and Nondestructive Evaluation Laboratory Planning Guide aids in establishing expectations for both NASA and non- NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware developers. It is intended to assist their project engineering personnel in materials analysis planning and execution. Material covered includes a roadmap of the analysis process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, products, and inputs necessary to define scope of analysis, cost, and schedule are included as an appendix to the guide.

  19. Maintaining data quality in an environmental testing laboratory

    SciTech Connect

    Cohen, Roy J.

    2001-03-05

    In today's competitive and highly litigious world, it is critical that any laboratory generating data for the environmental and allied industries have a world-class Quality Assurance Program. This Plan must conform to the requirements of every agency and client with whom the lab does business. The goal of such a program is data defensibility; i.e., data validity. Data (usually qualitative analyte [compound or element] identifications and quantitative numerical results) are the end results of nearly all analytical laboratory processes, and the source of revenue. Clients pay for results. The clients expect the results to be accurate, precise, and repeatable. If their data has to go to court, the laboratory will be called upon to defend the accuracy and precision of their work. Without a strong QA program, this will be impossible. The potential implications and repercussions of non-defensible lab data are far-reaching and very costly in terms of loss of future revenues and in legal judgments.

  20. Jet Propulsion Laboratory Environmental Verification Processes and Test Effectiveness

    NASA Technical Reports Server (NTRS)

    Hoffman, Alan R.; Green, Nelson W.

    2006-01-01

    Viewgraphs on the JPL processes for enviornmental verification and testing of aerospace systems is presented. The topics include: 1) Processes: a) JPL Design Principles b) JPL Flight Project Practices; 2) Environmental Verification; and 3) Test Effectiveness Assessment: Inflight Anomaly Trends.