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Sample records for bo wang chen

  1. From Wang-Chen System with Only One Stable Equilibrium to a New Chaotic System Without Equilibrium

    NASA Astrophysics Data System (ADS)

    Pham, Viet-Thanh; Wang, Xiong; Jafari, Sajad; Volos, Christos; Kapitaniak, Tomasz

    2017-06-01

    Wang-Chen system with only one stable equilibrium as well as the coexistence of hidden attractors has attracted increasing interest due to its striking features. In this work, the effect of state feedback on Wang-Chen system is investigated by introducing a further state variable. It is worth noting that a new chaotic system without equilibrium is obtained. We believe that the system is an interesting example to illustrate the conversion of hidden attractors with one stable equilibrium to hidden attractors without equilibrium.

  2. Chen-Nester-Tung quasi-local energy and Wang-Yau quasi-local mass

    NASA Astrophysics Data System (ADS)

    Liu, Jian-Liang; Yu, Chengjie

    2017-10-01

    In this paper, we show that the Chen-Nester-Tung (CNT) quasi-local energy with 4D isometric matching references is closely related to the Wang-Yau (WY) quasi-local energy. As a particular example, we compute the second variation of the CNT quasi-local energy for axially symmetric Kerr-like spacetimes with axially symmetric embeddings at the obvious critical point (0 , 0) and find that it is a saddle critical point in most of the cases. Also, as a byproduct, we generalize a previous result about the coincidence of the CNT quasi-local energy and Brown-York mass for axially symmetric Kerr-like spacetimes by Tam and the first author Liu and Tam (2016) to general spacetimes.

  3. [Textual research on the chronicle of Wang Fengchun's life].

    PubMed

    Wu, Z

    1999-10-01

    Wang Fengchun was a noted doctor in Beijing, but there were a lot of discrepancies and errors about the chronicle of Wang's life in the literatures. This article was a textual research on the chronicle of Wang Fengchun's life, such as the date of birth, the time when migrated to Beijing, and the number of years practised medicine in Beijing, mostly based on the Bo Lu Yi An.

  4. An approach to improve Wang-Smith chaotic simulated annealing.

    PubMed

    Zheng, Liying; Wang, Kejun; Tian, Kai

    2002-10-01

    Previous research shows that Wang-Smith chaotic simulated annealing, which employs a gradually decreasing time-step, has only a scaling effect to computational energy of the Hopfield model without changing its shape. This makes the net has sensitive dependence on the value of damping factor. Considering Chen-Aihara chaotic simulated annealing with decaying self-coupling has a shape effect to computational energy of the Hopfield model, a novel approach to improve Wang-Smith chaotic simulated annealing, which reaps the benefits of Wang-Smith model and Chen-Aihara model, is proposed in this paper. With the aid of this method the improved model can affect on computational energy of the Hopfield model from scaling and shape. By adjusting the time-step, the improved neural network can also pass from a chaotic to a non-chaotic state. From numerical simulation experiments, we know that the improved model can escape from local minima more efficiently than original Wang-Smith model.

  5. The genus name Ensifer Casida 1982 takes priority over Sinorhizobium Chen et al. 1988, and Sinorhizobium morelense Wang et al. 2002 is a later synonym of Ensifer adhaerens Casida 1982. Is the combination "Sinorhizobium adhaerens" (Casida 1982) Willems et al. 2003 legitimate? Request for an Opinion.

    PubMed

    Young, J M

    2003-11-01

    The synonymy of the genera Ensifer and Sinorhizobium was recently reported, but it was proposed that the later-named genus, Sinorhizobium, take priority in nomenclature. There is no justification in the International Code of Nomenclature of Bacteria (Prokaryotes) for this step; Ensifer is the correct name of the genus, with Ensifer adhaerens as the type species. Species previously allocated to Sinorhizobium are here proposed as the new combinations Ensifer arboris, Ensifer fredii, Ensifer kostiensis, Ensifer kummerowiae, Ensifer medicae, Ensifer meliloti, Ensifer saheli, Ensifer terangae and Ensifer xinjiangensis. Sinorhizobium morelense was proposed in 2002 [Wang, E. T., Tan, Z. Y., Willems, A., Fernández-López, M., Reinhold-Hurek, B. & Martínez-Romero, E., Int J Syst Evol Microbiol 52, 1687-1693, 2002], but a consideration of all published data indicate that it is a nitrogen-fixing genomovar and later heterotypic synonym of Ensifer adhaerens. A Request for an Opinion is made as to whether or not the combination "Sinorhizobium adhaerens" (Casida 1982) Willems et al. 2003 is legitimate.

  6. Editorial: Which Wei Wang?

    SciTech Connect

    Sprouse, Gene D.

    2007-12-01

    The APS journals receive manuscripts from scientists all over the world. For authors whose names cannot be expressed in Latin characters, their names in the byline must be transliterated, a process that is not necessarily bidirectionally unique. For example, the eight Chinese names all transliterate as Wei Wang. To remove some of the ambiguity arising from this unfortunate degeneracy of names, APS will allow some authors the option to include their names in their own language in parentheses after the transliterated name, such as Wei Wang. The option to present names in the article byline in this manner is an experiment initially offered to Chinese, Japanese, and Korean authors, whose names can be expressed in Unicode characters. An example of a Japanese name is Tadanori Minamisono and a Korean name is Chang Kee Jung. In the English text the given name precedes the family name, while the reverse is true for the characters. As we gain experience, we may be able to broaden this offer to other languages. Authors who wish to try this option will need to prepare their manuscripts by following the special instructions at http://authors.aps.org/names.html.

  7. Chen Li: China's elder psychologist.

    PubMed

    Blowers, G H

    1998-01-01

    Chen Li is one of a small group of psychologists in China who trained abroad early in their careers, returned to teach and do research, and continued doing so into later life beyond normal retirement age. His contacts with a number of prominent psychologists in England and Germany in the 1930s, and his inadvertent position at the center of a political row in China in the 1960s, leading to the shutting down of psychology for 10 years, made him historically important. Known for his work in organizational psychology and education, he is a distinguished psychologist and educational leader. Although trained as an experimentalist, he now embraces a broader view of psychology but remains emphatic it should be applied to real-life problems.

  8. Chen-Ning Yang and my Student Days at Stony Brook

    NASA Astrophysics Data System (ADS)

    Chao, Alex

    2008-12-01

    The time was 35 years ago. Chen-Ning Yang, my Ph.D. advisor at Stony Brook, thoughtfully led me through a career decision path that I followed, and have enjoyed since then. This is my reminiscence of that time so critical to my career.

  9. Luminescence study of γ-ray and C5+ ion beam-irradiated LiCaBO3:Cu phosphor

    NASA Astrophysics Data System (ADS)

    Oza, Abha H.; Dhoble, N. S.; Lochab, S. P.; Dhoble, S. J.

    2015-07-01

    Cu-doped LiCaBO3 phosphors were prepared by modified solid-state synthesis and the formation of compound was confirmed by X-ray diffraction study. LiCaBO3:Cu+ (Cu = 0.02, 0.05, 0.1 and 0.2 mol%) were studied for photoluminescence (PL) study and prominent PL emission spectra were obtained for Cu+ with transition 3d94s1 → 3d10. The phosphors were further studied by thermoluminescence (TL) property for exposure to γ-ray irradiation of 1.2 rad with 137Cs source. TL of LiCaBO3:Cu was also studied for C5+ (3.75 × 1012 ion cm-2) beam irradiation for 1 min exposure time. Trapping parameters (activation energy and frequency factor) for single deconvoluted peaks were obtained by Chen's peak shape method.

  10. Stability Analysis of Distributed Order Fractional Chen System

    PubMed Central

    Aminikhah, H.; Refahi Sheikhani, A.; Rezazadeh, H.

    2013-01-01

    We first investigate sufficient and necessary conditions of stability of nonlinear distributed order fractional system and then we generalize the integer-order Chen system into the distributed order fractional domain. Based on the asymptotic stability theory of nonlinear distributed order fractional systems, the stability of distributed order fractional Chen system is discussed. In addition, we have found that chaos exists in the double fractional order Chen system. Numerical solutions are used to verify the analytical results. PMID:24489508

  11. Generalized Sagnac-Wang-Fizeau formula

    NASA Astrophysics Data System (ADS)

    Ori, A.; Avron, J. E.

    2016-12-01

    We present a special-relativistic analysis of deformable interferometers where counterpropagating beams share a common optical path. The optical path is allowed to change rather arbitrarily and need not be stationary. We show that the phase shift has two contributions: One contribution is independent of the refractive index n and has the form of a line integral. This term gives the Wang empirical formula for deformable Sagnac interferometers. The second term is quadratic in n and has the form of a double integral. The analysis provides a unifying framework incorporating the Sagnac, Wang, and Fizeau effects in a single scheme, gives a rigorous proof of Wang empirical formula, and can be used to study various perturbations of Sagnac interferometers.

  12. Free and Beautiful: Lucia Chen--New York Public Library

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    This article details the work of Lucia Chen of the New York Public Library. Lucia Chen combined her two passions--organization and beautification--in her recent project, creating an online version of the New York Public Library's (NYPL) legendary picture collection. Artists ranging from set designers to filmmakers have long used the collection,…

  13. Free and Beautiful: Lucia Chen--New York Public Library

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    This article details the work of Lucia Chen of the New York Public Library. Lucia Chen combined her two passions--organization and beautification--in her recent project, creating an online version of the New York Public Library's (NYPL) legendary picture collection. Artists ranging from set designers to filmmakers have long used the collection,…

  14. Bridge No. 1601, Third B&O Crossing, over CSX (former B&O) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bridge No. 1601, Third B&O Crossing, over CSX (former B&O) tracks and North Branch Road, looking northwest. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  15. Revision of the Taiwanese millipede genus Chamberlinius Wang, 1956, with descriptions of two new species and a reclassification of the tribe Chamberlinini (Diplopoda, Polydesmida, Paradoxosomatidae, Paradoxosomatinae)

    PubMed Central

    Chen, Chao-Chun; Golovatch, Sergei I.; Chang, Hsueh-Wen; Chen, Shyh-Hwang

    2011-01-01

    Abstract The millipede genus Chamberlinius is basically confined to Taiwan, with only one of the four known species presumably introduced to southern Japan. Both previously known species are redescribed, based on new material: Chamberlinius hualienensis Wang, 1956 (the type species) and Chamberlinius piceofasciatus (Gressitt, 1941), the latter being a new subjective senior synonym of Chamberlinius shengmui Wang, 1957, syn. n. Two further congeners are described as new: Chamberlinius pessior sp. n. and Chamberlinius sublaevus sp. n. The genus is re-diagnosed, all of its four species are keyed, and their distributions mapped. The tribe Chamberlinini is reclassified and, based on gonopod traits, shown to comprise the following five genera: Chamberlinius Wang, 1956, Haplogonosoma Brölemann, 1916, Riukiupeltis Verhoeff, 1939, Aponedyopus Verhoeff, 1939 and Geniculodesmus Chen, Golovatch and Chang, 2008. PMID:21594069

  16. Wang-Landau integration --- The application of Wang-Landau sampling in numerical integration

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Wuest, Thomas; Landau, David P.; Qing Lin, Hai

    2007-03-01

    Wang-Landau sampling was first introduced to simulate the density of states in energy space for various physical systems. This technique can be extended to numerical integrations due to certain similarities in nature of these two problems. It can be further applied to study quantum many-body systems. We report the feasibility of this application by discussing the correspondence between Wang-Landau integration and Wang-Landau sampling for Ising model. Numerical results for 1D and 2D integrations are shown. In particular, the utilization of this algorithm in the periodic lattice Anderson model is discussed as an illustrative example.

  17. Consistent Yokoya-Chen Approximation to Beamstrahlung(LCC-0010)

    SciTech Connect

    Peskin, M

    2004-04-22

    I reconsider the Yokoya-Chen approximate evolution equation for beamstrahlung and modify it slightly to generate simple, consistent analytical approximations for the electron and photon energy spectra. I compare these approximations to previous ones, and to simulation data.I reconsider the Yokoya-Chen approximate evolution equation for beamstrahlung and modify it slightly to generate simple, consistent analytical approximations for the electron and photon energy spectra. I compare these approximations to previous ones, and to simulation data.

  18. Magnitude of the Wang-Landau error

    NASA Astrophysics Data System (ADS)

    Brown, Gregory; Rikvold, PA; Odbadrakh, Kh; Nicholson, DM

    2016-09-01

    The Wang-Landau algorithm is an entropic sampling method that incoroporates an update factor ln fi , which introduces a self-avoidance tendency into the random walk. Continued sampling at constant ln fi leads to a steady state estimate of the density of states ln gi (E). We find numerically that the difference between ln gi (E) and the true density of states ln g (E) is proportional to the update factor.

  19. Critical endpoint behavior: A Wang Landau study

    NASA Astrophysics Data System (ADS)

    Landau, D. P.; Wang, Fugao; Tsai, Shan-Ho

    2008-07-01

    We study the critical endpoint behavior using an asymmetric Ising model with two- and three-body interactions on a triangular lattice, in the presence of an external field. The simulation method we use is Wang-Landau sampling in a two-dimensional parameter space. We observe a clear divergence of the curvature of the spectator phase boundary and of the magnetization coexistence diameter derivative at the critical endpoint, and the exponents for both divergences agree well with previous theoretical predictions.

  20. Comment on “Sensitivity analysis and determination of streambed leakance and aquifer hydraulic properties” by X. Chen and X. Chen

    NASA Astrophysics Data System (ADS)

    Christensen, Steen

    2005-03-01

    Chen and Chen [Chen, X., Chen, X., 2003. Sensitivity analysis and determination of streambed leakance and aquifer hydraulic properties. Journal of Hydrology 284, 270-284] carried out a study that is very similar to that of Christensen [Christensen, S., 2000. On the estimation of stream flow depletion parameters by drawdown analysis. Ground Water 38 (5), 726-734]. Chen and Chen [Chen, X., Chen, X., 2003. Sensitivity analysis and determination of streambed leakance and aquifer hydraulic properties. Journal of Hydrology 284, 270-284] made the analysis for a few specific cases with very similar hydraulic properties, while that of Christensen [Christensen, S., 2000. On the estimation of stream flow depletion parameters by drawdown analysis. Ground Water 38 (5), 726-734] presents results in dimensionless form that can be used for a wide range of hydraulic parameter values, pumping rates, pumping durations, and error magnitudes. In one case Chen and Chen [Chen, X., Chen, X., 2003. Sensitivity analysis and determination of streambed leakance and aquifer hydraulic properties. Journal of Hydrology 284, 270-284] made a mistake in their analysis. In other cases inaccuracies in the approximations used by Chen and Chen [Chen, X., Chen, X., 2003. Sensitivity analysis and determination of streambed leakance and aquifer hydraulic properties. Journal of Hydrology 284, 270-284] seem to have lead to results that they misinterpret. Chen and Chen [Chen, X., Chen, X., 2003. Sensitivity analysis and determination of streambed leakance and aquifer hydraulic properties. Journal of Hydrology 284, 270-284] would have been concerned about this if they had studied and compared with the results of Christensen [Christensen, S., 2000. On the estimation of stream flow depletion parameters by drawdown analysis. Ground Water 38 (5), 726-734] that were published more than 2 years before their submittal. This would also have shown that the major conclusions of Chen and Chen [Chen, X., Chen, X., 2003

  1. Numerical integration using Wang Landau sampling

    NASA Astrophysics Data System (ADS)

    Li, Y. W.; Wüst, T.; Landau, D. P.; Lin, H. Q.

    2007-09-01

    We report a new application of Wang-Landau sampling to numerical integration that is straightforward to implement. It is applicable to a wide variety of integrals without restrictions and is readily generalized to higher-dimensional problems. The feasibility of the method results from a reinterpretation of the density of states in statistical physics to an appropriate measure for numerical integration. The properties of this algorithm as a new kind of Monte Carlo integration scheme are investigated with some simple integrals, and a potential application of the method is illustrated by the evaluation of integrals arising in perturbation theory of quantum many-body systems.

  2. Distinguishing Lorenz and Chen Systems Based Upon Hamiltonian Energy Theory

    NASA Astrophysics Data System (ADS)

    Cang, Shijian; Wu, Aiguo; Wang, Zenghui; Chen, Zengqiang

    Solving the linear first-order Partial Differential Equations (PDEs) derived from the unified Lorenz system, it is found that there is a unified Hamiltonian (energy function) for the Lorenz and Chen systems, and the unified energy function shows a hyperboloid of one sheet for the Lorenz system and an ellipsoidal surface for the Chen system in three-dimensional phase space, which can be used to explain that the Lorenz system is not equivalent to the Chen system. Using the unified energy function, we obtain two generalized Hamiltonian realizations of these two chaotic systems, respectively. Moreover, the energy function and generalized Hamiltonian realization of the Lü system and a four-dimensional hyperchaotic Lorenz-type system are also discussed.

  3. Wang-Landau sampling for homopolymer collapse

    NASA Astrophysics Data System (ADS)

    Seaton, Daniel T.; Mitchell, Steven J.; Landau, David P.

    2008-03-01

    We explore the behavior of a continuum-homopolymer model using the Wang-Landau algorithm, concentrating on phase transitions such as the coil-globule and solid-liquid transitions. Using the density of states generated by the Wang-Landau algorithm, we calculate various thermodynamic quantities, e.g., the internal energy and specific heat. We also study how algorithmic parameters, such as sampling boundaries (maximum and minimum energies for random walks) and the final value of the modification factor, affect these quantities. In particular, we observe how the sampling boundaries can significantly alter the transition behavior. Our results are compared with two recent studies that yielded contradictory results, one using the bond-fluctuation model and the other using a continuum model similar to our own. We find that the transitions seen in our model are much more similar to those in the bond-fluctuation study. The careful analysis of the effects of algorithmic parameters on thermodynamic quantities should be relevant to the study of other polymeric/protein models.

  4. Adaptive synchronization of Rossler and Chen chaotic systems

    NASA Astrophysics Data System (ADS)

    Li, Zhi; Han, Chong-Zhao

    2002-07-01

    A novel adaptive synchronization method is proposed for two identical Rossler and Chen systems with uncertain parameters. Based on Lyapunov stability theory, we derive an adaptive controller without the knowledge of the system parameters, which can make the states of two identical Rossler and Chen systems globally asymptotically synchronized. Especially, when some unknown uncertain parameters are positive, we can make the controller more simple and, besides, the controller is independent of those positive uncertain parameters. All results are proved using a well-known Lyapunov stability theorem. Numerical simulations are given to validate the proposed synchronization approach.

  5. HyBoLT Flight Experiment

    NASA Technical Reports Server (NTRS)

    Chen, Fang-Jeng (Frank); Berry, Scott A.

    2010-01-01

    HyBoLT was a Hypersonic Boundary Layer Transition flight experiment funded by the Hypersonics Project of the Fundamental Aeronautics Program in NASA's Aeronautics Research Mission Directorate. The HyBoLT test article mounted on the top of the ALV X-1 rocket was launched from Virginia's Wallops Island on August 22, 2008. Unfortunately a problem in the rocket's flight control system caused the vehicle to veer off the designed flight course. Launch officials activated a self-destruct mechanism in the rocket's nose cone after 20 seconds into flight. This report is a closeout document about the HyBoLT flight experiment. Details are provided of the objectives and approach associated with this experimental program as well as the 20 seconds flight data acquired before the vehicle was destroyed.

  6. Beauty and physics: 13 important contributions of Chen Ning Yang

    NASA Astrophysics Data System (ADS)

    Shi, Yu

    2014-06-01

    In 2012, Chen Ning Yang received a 90th birthday gift in the form of a black cube inscribed with his 13 most important contributions, which cover four major areas of physics: statistical mechanics, condensed matter physics, particle physics and field theory. We briefly describe these 13 contributions and make general comments about Yang's distinctive style as a trailblazing leader in research.

  7. Asiago classification of ASASSN-15bo

    NASA Astrophysics Data System (ADS)

    Benetti, S.; Tomasella, L.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Pastorello, A.; Tartaglia, L.; Terreran, G.; Turatto, M.

    2015-02-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of ASASSN-15bo (ATel #6989). The observation was performed with the Asiago 1.82m Copernico Telescope (+AFOSC; range 340-820 nm; resolution 1.4 nm), equipped with the CCD Andor IKON L936.

  8. Synchronization of Rossler and Chen chaotic dynamical systems using active control

    NASA Astrophysics Data System (ADS)

    Agiza, H. N.; Yassen, M. T.

    2001-01-01

    This Letter presents chaos synchronization of two identical Rossler and Chen systems by using active control. The proposed technique is applied to achieve chaos synchronization for the Rossler and Chen dynamical systems. We demonstrate that a coupled Rossler and Chen systems can be synchronized. Numerical simulations are used to show the effectiveness of the proposed control method.

  9. Modification for synchronization of Rossler and Chen chaotic systems

    NASA Astrophysics Data System (ADS)

    Li, Zhi; Han, Chongzhao; Shi, Songjiao

    2002-08-01

    Active control is an effective method for making two identical Rossler and Chen systems be synchronized. However, this method works only for a certain class of chaotic systems with known parameters both in drive systems and response systems. Modification based on Lyapunov stability theory is proposed in order to overcome this limitation. An adaptive synchronization controller, which can make the states of two identical Rossler and Chen systems globally asymptotically synchronized in the presence of system's unknown constant parameters, is derived. Especially, when some unknown parameters are positive, we can make the controller more simple, besides, the controller is independent of those positive uncertain parameters. At last, when the condition that arbitrary unknown parameters in two systems are identical constants is cancelled, we demonstrate that it is possible to synchronize two chaotic systems. All results are proved using a well-known Lyapunov stability theorem. Numerical simulations are given to validate the proposed synchronization approach.

  10. Dynamic controller design for exponential synchronization of Chen chaotic system

    NASA Astrophysics Data System (ADS)

    Park, Ju H.; Lee, S. M.; Kwon, O. M.

    2007-07-01

    The Letter considers synchronization of Chen chaotic system. The problems of determining the exponential stability and estimating the exponential convergence rate for the synchronization are investigated by employing the Lyapunov functional method and linear matrix inequality (LMI) technique. For this end, a dynamic controller is proposed for the first time and a criterion for existence of the controller is given in terms of LMIs. Finally, numerical simulations are presented to show the effectiveness of the proposed chaos synchronization scheme.

  11. The Wang-Landau Sampling Algorithm

    NASA Astrophysics Data System (ADS)

    Landau, David P.

    2003-03-01

    Over the past several decades Monte Carlo simulations[1] have evolved into a powerful tool for the study of wide-ranging problems in statistical/condensed matter physics. Standard methods sample the probability distribution for the states of the system, usually in the canonical ensemble, and enormous improvements have been made in performance through the implementation of novel algorithms. Nonetheless, difficulties arise near phase transitions, either due to critical slowing down near 2nd order transitions or to metastability near 1st order transitions, thus limiting the applicability of the method. We shall describe a new and different Monte Carlo approach [2] that uses a random walk in energy space to determine the density of states directly. Once the density of states is estimated, all thermodynamic properties can be calculated at all temperatures. This approach can be extended to multi-dimensional parameter spaces and has already found use in classical models of interacting particles including systems with complex energy landscapes, e.g., spin glasses, protein folding models, etc., as well as for quantum models. 1. A Guide to Monte Carlo Simulations in Statistical Physics, D. P. Landau and K. Binder (Cambridge U. Press, Cambridge, 2000). 2. Fugao Wang and D. P. Landau, Phys. Rev. Lett. 86, 2050 (2001); Phys. Rev. E64, 056101-1 (2001).

  12. BoLA class I polymorphism and in vitro immune response to M. bovis antigens.

    PubMed

    Longeri, M; Polli, M; Ponti, W; Zanotti, M

    1993-01-12

    bovinen und Geflügel PPDs. 2. Phagozyten Aktivität gegen M. bovis. 3. Zeil-Oberflächen, Expression der Klasse II Moleküle. 4. Anteile der Lymphozyten Populationen und Subpopulationen. Im in vitro Lymphozyten-Stimulationstest waren alle Tiere und Klassen responder. Tiere mit A10 BoLA I zeigten höhere c.p.m. und Indexwerte als die anderen; diese Werte waren in signifikant positiver Beziehung mit der PPD von M. bovis und auch mit M. avium (P < .01). BoLA Typ A14 zeigte leicht signifikant positive Korrelation mit wirksamerer Phagozyten Aktivität. BoLA Klasse I Typ scheint nicht den Prozentsatz der positiven Zellen der Klasse II und der Leukozyten der PBM signifikant zu beeinflussen. RESUMEN: Polimorfismo de BoLA clase I y immunidad a los antigenos del M. bovis Se escojeron 47 novillos dentro de un grupo de 119 animales que segun analisis previamente hecha tenian BoLA de clase I. Estos 47 novillos fueron escojidos de manera que tuvieran 9 distintos tipos de MHC (A6, A6.9, A10, A11, A14, A15, A30, W16, M103), la misma edad, las mismas condiciones de cria. Estos animales fueron inoculados subcutaneo con M. bovis matados en una suspension oleosa y la misma inoculacion fue repetida una secunda vez despues de dos dias. Por cada animal se tomaron muestras de sangre antes y 21 dias despues de la inoculacion de arriba. Las muestras de sangre fueron pruebaoas con: 1. Stimulacion Lymhocitaria con PPD bovina y avicola. 2. Actividad phagocitaria a M. bovis. 3. Expresion sobre la superficie celular de moleculas de clase II. 4. Porcentaje de poblaciones y de subpob-laciones de leucocitos. Todos los animales y todos los tipos de MHC dieron respuestas positivas en las pruebas de Stimulacion Lymphocitaria. Los animales que tenian la BoLA A10 presentaron valores de c.p.m. y indices mas altos de los demas animales. Estos valores se encontraron significativamente y positivamente relacionados sea a la PPD bovina que a la PPD avicola. Por medio de la analisis de varianzas se encontro que el

  13. Clostridium botulinum strains producing BoNT/F4 or BoNT/F5.

    PubMed

    Raphael, Brian H; Bradshaw, Marite; Kalb, Suzanne R; Joseph, Lavin A; Lúquez, Carolina; Barr, John R; Johnson, Eric A; Maslanka, Susan E

    2014-05-01

    Botulinum neurotoxin type F (BoNT/F) may be produced by Clostridium botulinum alone or in combination with another toxin type such as BoNT/A or BoNT/B. Type F neurotoxin gene sequences have been further classified into seven toxin subtypes. Recently, the genome sequence of one strain of C. botulinum (Af84) was shown to contain three neurotoxin genes (bont/F4, bont/F5, and bont/A2). In this study, eight strains containing bont/F4 and seven strains containing bont/F5 were examined. Culture supernatants produced by these strains were incubated with BoNT/F-specific peptide substrates. Cleavage products of these peptides were subjected to mass spectral analysis, allowing detection of the BoNT/F subtypes present in the culture supernatants. PCR analysis demonstrated that a plasmid-specific marker (PL-6) was observed only among strains containing bont/F5. Among these strains, Southern hybridization revealed the presence of an approximately 242-kb plasmid harboring bont/F5. Genome sequencing of four of these strains revealed that the genomic backgrounds of strains harboring either bont/F4 or bont/F5 are diverse. None of the strains analyzed in this study were shown to produce BoNT/F4 and BoNT/F5 simultaneously, suggesting that strain Af84 is unusual. Finally, these data support a role for the mobility of a bont/F5-carrying plasmid among strains of diverse genomic backgrounds.

  14. Synthesis of composite structures on the basis of GaBO3 and FeBO3 trigonal crystals

    NASA Astrophysics Data System (ADS)

    Mustafaeva, S. M.; Matvienko, M. P.; Mogilenec, Yu A.; Maksimova, E. M.; Nauhatsky, I. A.; Strugatsky, M. B.; Seleznyova, K. A.; Yagupov, S. V.

    2016-11-01

    Film of iron borate FeBO3 is of a great interest as a model object for various scientific studies and is a promising material for practical applications in different branches of experimental science and engineering. Thin magnetic films of FeBO3 on GaBO3 single crystal substrate were prepared by a liquid phase epitaxy route. In order to observe a mechanism of film formation we have carried out optical microscopy studies. X-ray diffraction analysis has confirmed the existence of the FeBO3 layer on the GaBO3 substrate.

  15. The role of Wang-Landau sampling in materials development

    NASA Astrophysics Data System (ADS)

    Landau, David

    2012-02-01

    An understanding of the thermodynamic behavior of materials as well as the prediction of the properties of ``materials by design'' often depends upon knowledge of the free energy of the system under study. Computer simulations offer a powerful tool for such investigations, but traditional methods often suffer from long time scales and metastable states due to the roughness of the free energy landscape. Wang-Landau samplingootnotetextF. Wang and D. P. Landau, Phys. Rev. Lett. 86, 2050 (2001); F. Wang and D. P. Landau, Phys. Rev. E 64, 05610 (2001). is a powerful alternative to traditional Monte Carlo algorithms which can alleviate many such problems. We will review the Wang-Landau algorithm and discuss various implementations as well as possible application to materials development.

  16. Avoiding boundary effects in Wang-Landau sampling

    NASA Astrophysics Data System (ADS)

    Schulz, B. J.; Binder, K.; Müller, M.; Landau, D. P.

    2003-06-01

    A simple modification of the “Wang-Landau sampling” algorithm removes the systematic error that occurs at the boundary of the range of energy over which the random walk takes place in the original algorithm.

  17. [Study of dates of birth and death of WANG Tao].

    PubMed

    Song, Zhen-Min

    2011-03-01

    The dates of birth and death of WANG Tao, a famous doctor in Tang dynasty, are not found in literature and scholars have different points upon this subject. It could be sure that WANG Tao was appointed mayor of Huayuan county in the ninth year of Kaiyuan period (721) and in December of the fourteenth year of Tianbao period (756) he the revolt in Hejian. The recording after 756 could not be found in literature. According to the official system in Tang dynasty that officers retired at their age of 70, it could be sure that WANG Tao was less than 70 year old in 756. Considering his age when he was the county mayor in 721, it could be speculated that WANG Tao was born during the third year of Chuigong period (687) to the second year of Changshou period (693), and his death date should be some date after 756. But it couldn't be validated.

  18. Chemical gas-dynamics beyond Wang Chang-Uhlenbeck's kinetics

    SciTech Connect

    Kolesnichenko, Evgeniy G.; Gorbachev, Yuriy E.

    2014-12-09

    Wang Chang-Uhlenbeck equation does not give possibility to take into account intermolecular processes such as redistribution of the energy among different degrees of freedom. The modification of the generalized Wang Chang-Uhlenbeck equation including such processes is proposed. It allows to study for instance the kinetics of non-radiative transitions. Limitations of this approach are connected with the requirements of absence of polarization of rotational momentum and phases of intermolecular vibrations.

  19. Chemical gas-dynamics beyond Wang Chang-Uhlenbeck's kinetics

    NASA Astrophysics Data System (ADS)

    Kolesnichenko, Evgeniy G.; Gorbachev, Yuriy E.

    2014-12-01

    Wang Chang-Uhlenbeck equation does not give possibility to take into account intermolecular processes such as redistribution of the energy among different degrees of freedom. The modification of the generalized Wang Chang-Uhlenbeck equation including such processes is proposed. It allows to study for instance the kinetics of non-radiative transitions. Limitations of this approach are connected with the requirements of absence of polarization of rotational momentum and phases of intermolecular vibrations.

  20. Massively parallel Wang-Landau sampling on multiple GPUs

    NASA Astrophysics Data System (ADS)

    Yin, Junqi; Landau, D. P.

    2012-08-01

    Wang-Landau sampling is implemented on the Graphics Processing Unit (GPU) with the Compute Unified Device Architecture (CUDA). Performances on three different GPU cards, including the new generation Fermi architecture card, are compared with that on a Central Processing Unit (CPU). The parameters for massively parallel Wang-Landau sampling are tuned in order to achieve fast convergence. For simulations of the water cluster systems, we obtain an average of over 50 times speedup for a given workload.

  1. Massively parallel Wang Landau sampling on multiple GPUs

    SciTech Connect

    Yin, Junqi; Landau, D. P.

    2012-01-01

    Wang Landau sampling is implemented on the Graphics Processing Unit (GPU) with the Compute Unified Device Architecture (CUDA). Performances on three different GPU cards, including the new generation Fermi architecture card, are compared with that on a Central Processing Unit (CPU). The parameters for massively parallel Wang Landau sampling are tuned in order to achieve fast convergence. For simulations of the water cluster systems, we obtain an average of over 50 times speedup for a given workload.

  2. Dynamic states of a unidirectional ring of chen oscillators

    SciTech Connect

    Carvalho, Ana

    2015-03-10

    We study curious dynamical patterns appearing in a network of a unidirectional ring of Chen oscillators coupled to a ‘buffer’ cell. The network has Z{sub 3} exact symmetry group. We simulate the coupled cell systems associated to the two networks and obtain steady-states, rotating waves, quasiperiodic behavior, and chaos. The different patterns appear to arise through a sequence of Hopf, period-doubling and period-halving bifurcations. The network architecture appears to explain some patterns, whereas the properties of the chaotic oscillator may explain others. We use XPPAUT and MATLAB to compute numerically the relevant states.

  3. The rubber band revisited: Wang-Landau simulation

    NASA Astrophysics Data System (ADS)

    Ferreira, Lucas S.; Caparica, Álvaro A.; Neto, Minos A.; Galiceanu, Mircea D.

    2012-10-01

    In this work we apply Wang-Landau simulations to a simple model which has exact solutions both in the microcanonical and canonical formalisms. The simulations were carried out by using an updated version of the Wang-Landau sampling. We consider a homopolymer chain consisting of N monomers units which may assume any configuration on the two-dimensional lattice. By imposing constraints to the moves of the polymers we obtain three different models. Our results show that updating the density of states only after every N monomer moves leads to a better precision. We obtain the specific heat and the end-to-end distance per monomer and test the precision of our simulations by comparing the location of the maximum of the specific heat with the exact results and conventional Wang-Landau simulations for the three types of walk.

  4. [Discussion on WANG Guo-rui's acupuncture academy thought].

    PubMed

    Gao, Xi-Yan; Wang, Xin; Gao, Ling; Chen, Xin-Wang

    2013-12-01

    Through study on Bianque Shenying Zhenjiu Yulong Jing (Bianque's Classic of Effective Acupuncture Prescriptions), acupuncture experiences and ideology of WANG Guo-rui, an acupuncture physician of the Yuan Dynasty (1271-1368), is discussed in this article. Inherited and carried forward DOU's acupuncture theory, WANG Guo-rui encouraged to use experiential points and to expand extra points. Penetrating needling method was created, and the application of acupoints according to needling opportunities and seasonal factors were enriched by him. Great importance was also attached on treatment according to differentiation of syndromes, which including the simultaneous acupuncture and moxibustion, simultaneous reinforcing and reducing, reducing after reinforcing, reinforcing after reducing, predomination of reducing and predomination of reinforcing. The flexible treating methods are still extensively adopted in clinic nowadays. WANG Guo-rui is a master of clinical acupuncture who made great contribution to the development of acupuncture and moxibustion.

  5. Convergence and refinement of the Wang Landau algorithm

    NASA Astrophysics Data System (ADS)

    Lee, Hwee Kuan; Okabe, Yutaka; Landau, D. P.

    2006-07-01

    Recently, Wang and Landau proposed a new random walk algorithm that can be very efficiently applied to many problems. Subsequently, there has been numerous studies on the algorithm itself and many proposals for improvements were put forward. However, fundamental questions such as what determines the rate of convergence has not been answered. To understand the mechanism behind the Wang-Landau method, we did an error analysis and found that a steady state is reached where the fluctuations in the accumulated energy histogram saturate at values proportional to [. This value is closely related to the error corrections to the Wang-Landau method. We also study the rate of convergence using different "tuning" parameters in the algorithm.

  6. [The anatomical concept of Ma Wang Dui archeological artifacts].

    PubMed

    Yang, Su-Tso

    2010-01-01

    Amongst the archeological findings of Ma Wang Dui that concern the human anatomy, the first noted was a well-preserved female corpse, which demonstrated superb antiseptic techniques of the ancient Chinese. Also, 14 medical books were excavated and revealed a prototype of human visceral anatomy. The differentiation between small and large intestines was absent, and only the term of "intestine" was mentioned. The term of "triple energizers" was absent, too. However, contexts of surface anatomy were already abundant. Analyzing the terms of relative position, the anatomical position portrayed by the Ma Wang Dui medical texts is very similar to that of modern medicine.

  7. The receptor binding domain of botulinum neurotoxin serotype A (BoNT/A) inhibits BoNT/A and BoNT/E intoxications in vivo.

    PubMed

    Ben David, Alon; Diamant, Eran; Barnea, Ada; Rosen, Osnat; Torgeman, Amram; Zichel, Ran

    2013-08-01

    The receptor binding domain of botulinum neurotoxin (BoNT), also designated the C terminus of the heavy chain (H(C)), is a promising vaccine candidate against botulism. In this study, a highly efficient expression system for the protein was developed in Escherichia coli, which provided yields that were 1 order of magnitude higher than those reported to date (350 mg H(C) per liter). The product was highly immunogenic, protecting mice from a challenge with 10(5) 50% lethal dose (LD(50)) after a single vaccination and generating a neutralizing titer of 49.98 IU/ml after three immunizations. In addition, a single boost with HC increased neutralizing titers by up to 1 order of magnitude in rabbits hyperimmunized against toxoid. Moreover, we demonstrate here for the first time in vivo inhibition of BoNT/A intoxication by H(C)/A, presumably due to a blockade of the neurotoxin protein receptor SV2. Administration of HC/A delayed the time to death from 10.4 to 27.3 h in mice exposed to a lethal dose of BoNT/A (P = 0.0005). Since BoNT/A and BoNT/E partially share SV2 isoforms as their protein receptors, the ability of H(C)/A to cross-inhibit BoNT/E intoxication was evaluated. The administration of H(C)/A together with BoNT/E led to 50% survival and significantly delayed the time to death for the nonsurviving mice (P = 0.003). Furthermore, a combination of H(C)/A and a subprotective dose of antitoxin E fully protected mice against 850 mouse LD(50) of BoNT/E, suggesting complementary mechanisms of protection consisting of toxin neutralization by antibodies and receptor blocking by H(C)/A.

  8. 76 FR 72387 - Order Relating to Xun Wang

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... the Regulations. The purpose of the conspiracy was to bring about the export of epoxy paint and epoxy... Industry Huaxing Construction Co. Ltd. (``Huaxing''). The epoxy paint and thinner were designated as EAR99... supply Huaxing with U.S.-origin PPG epoxy paint and thinner. During this meeting, Wang and...

  9. "Qi Yuling v. Chen Xiaoqi et al.": Judicial Interpretation by the Supreme People's Court

    ERIC Educational Resources Information Center

    Chinese Education and Society, 2006

    2006-01-01

    This article presents a reply to an inquiry regarding the Qi Yuling v. Chen Xiaoqi et al. case. The Supreme People's Court of China stated that by infringing on Qi Yuling's right to select and use her own name, Chen Xiaoqi et al. have violated Qi Yuling's fundamental constitutional right to education and have caused actual damages. Therefore, the…

  10. How Memory Is Tested Influences What Is Measured: Reply to Wyble and Chen (2017)

    ERIC Educational Resources Information Center

    Swallow, Khena M.; Jiang, Yuhong V.; Tan, Deborah H.

    2017-01-01

    In this response to Wyble and Chen's (2017) commentary on attribute amnesia, we hope to achieve several goals. First, we clarify how our view diverges from that described by Wyble and Chen. We argue that because the surprise memory test is disruptive, it is an insensitive tool for measuring the persistence of recently attended target attributes in…

  11. Reclassification of Deinococcus xibeiensis Wang et al. 2010 as a heterotypic synonym of Deinococcus wulumuqiensis Wang et al. 2010.

    PubMed

    Hong, Sunhee; Farrance, Christine E; Russell, Anne; Yi, Hana

    2015-03-01

    Two species of the genus Deinococcus, namely Deinococcus wulumuqiensis Wang et al. 2010 and Deinococcus xibeiensis Wang et al. 2010, were simultaneously proposed and described in the same publication. However, the identical 16S rRNA gene sequence of the two type strains strongly raised the probability of their relatedness at the species level. Thus, the genomic relatedness of the two species of the genus Deinococcus was investigated here to clarify their taxonomic status. The high (99.9 %) average nucleotide identity (ANI) between the genome sequences of the two type strains suggested that the two species are synonymous. Additional phenotypic data including enzymic activities and substrate-utilization profiles showed no pronounced differences between the type strains of the two species. Data from this study demonstrated that the two taxa constitute a single species. According to Rule 42 of the Bacteriological Code, we propose that D. xibeiensis Wang et al. 2010 should be reclassified as a subjective heterotypic synonym of D. wulumuqiensis Wang et al. 2010.

  12. Wang-Landau sampling with logarithmic windows for continuous models.

    PubMed

    Xie, Y L; Chu, P; Wang, Y L; Chen, J P; Yan, Z B; Liu, J-M

    2014-01-01

    We present a modified Wang-Landau sampling (MWLS) for continuous statistical models by partitioning the energy space into a set of windows with logarithmically shrinking width. To demonstrate its necessity and advantages, we apply this sampling to several continuous models, including the two-dimensional square XY spin model, triangular J1-J2 spin model, and Lennard-Jones cluster model. Given a finite number of bins for partitioning the energy space, the conventional Wang-Landau sampling may not generate sufficiently accurate density of states (DOS) around the energy boundaries. However, it is demonstrated that much more accurate DOS can be obtained by this MWLS, and thus a precise evaluation of the thermodynamic behaviors of the continuous models at extreme low temperature (kBT<0.1) becomes accessible. The present algorithm also allows efficient computation besides the highly reliable data sampling.

  13. Case 1. "Qi Yuling v. Chen Xiaoqi et al.": Opinion by the Higher People's Court of Shandong Province

    ERIC Educational Resources Information Center

    Chinese Education and Society, 2006

    2006-01-01

    This article presents the details of Qi Yuling v. Chen Xiaoqi et al case. The plaintiff Qi Yuling filed a lawsuit at the Intermediate People's Court in Zaozhuang, Shandong against defendants Chen Xiaoqi, Chen Kezheng, Jining Business School in Shandong ("Jining Business School"), the Eighth Middle School of Tengzhou, Shandong…

  14. Review of the genus Neotetricodes Zhang et Chen (Hemiptera: Fulgoromorpha: Issidae) with description of two new species.

    PubMed

    Chang, Zhi-Min; Yang, Lin; Zhang, Zheng-Guang; Chen, Xiang-Sheng

    2015-12-11

    Two new species of the issid genus Neotetricodes Zhang et Chen (Hemiptera: Fulgoromorpha: Issidae): Neotetricodes longispinus Chang et Chen sp. nov. (China: Yunnan) and Neotetricodes xiphoideus Chang et Chen sp. nov. (China: Yunnan) are described and illustrated. The generic characteristic is redefined. A checklist and key to the species of the genus are provided. The female genitalia of the genus are firstly described.

  15. GaBo{sub 3} crystal growth from flux

    SciTech Connect

    Rudenko, V.V.

    1995-03-01

    Synthesis of the chemical compound GaBO{sub 3} was first reported in paper, and the crystallographic determination of its structure and unit cell parameters was presented in paper. The chemical compound GaBO{sub 3} crystallizes in a calcite structure type with the hexagonal unit cell Parameters a{sub H} = 4.568 and c{sub H} = 14.18 {Angstrom}. GaBO{sub 3} crystals in the form of (111) hexagonal plates were grown from the solvent B{sub 2}O{sub 3}-Bi{sub 2}O{sub 3} by the method of sponvineous crystallization. That technique was hard to reproduce, however. We decided to grow a GaBO{sub 3} crystal as an object for possible studies of various physical properties. 8 refs., 2 figs.

  16. BoLA DYA polymorphism in Czech cattle.

    PubMed

    Horín, P; Matiasovic, J; Trtková, K; Pavlík, I

    1998-01-01

    Polymorphism at the BoLA DYA locus was determined in two groups of Czech Black Pied cattle by PCR-RFLP detecting substitutions at nucleotide positions 112 and 219. Animals for this study were nonrandomly selected according to their health status in two BoLA-associated infections: bovine leukosis (n = 59) and Johne's disease (n = 36). A group of noninfected Czech Red Pied cows (n = 37) was used for comparison. The frequencies of DYA alleles and haplotypes were virtually identical in the two selected groups as well as in the infection-free animals. In contrast, distribution of BoLA DRB3.2 alleles differed considerably between the infected groups as expected based on the previously detected associations with BoLA. The results suggest that the polymorphism of the DYA unexpressed gene was not influenced by selecting animals for this study according to their health status.

  17. A generic, hierarchical framework for massively parallel Wang Landau sampling

    SciTech Connect

    Vogel, Thomas; Li, Ying Wai; Wuest, Thomas; Landau, David P

    2013-01-01

    We introduce a parallel Wang Landau method based on the replica-exchange framework for Monte Carlo simulations. To demonstrate its advantages and general applicability for simulations of com- plex systems, we apply it to the self-assembly process in amphiphilic solutions and to lattice protein adsorption. Without loss of accuracy, the method gives significant speed-up on small architectures like multi-core processors, and should be beneficial for petaflop machines.

  18. Generic, hierarchical framework for massively parallel Wang-Landau sampling.

    PubMed

    Vogel, Thomas; Li, Ying Wai; Wüst, Thomas; Landau, David P

    2013-05-24

    We introduce a parallel Wang-Landau method based on the replica-exchange framework for Monte Carlo simulations. To demonstrate its advantages and general applicability for simulations of complex systems, we apply it to different spin models including spin glasses, the Ising model, and the Potts model, lattice protein adsorption, and the self-assembly process in amphiphilic solutions. Without loss of accuracy, the method gives significant speed-up and potentially scales up to petaflop machines.

  19. Generic, Hierarchical Framework for Massively Parallel Wang-Landau Sampling

    NASA Astrophysics Data System (ADS)

    Vogel, Thomas; Li, Ying Wai; Wüst, Thomas; Landau, David P.

    2013-05-01

    We introduce a parallel Wang-Landau method based on the replica-exchange framework for Monte Carlo simulations. To demonstrate its advantages and general applicability for simulations of complex systems, we apply it to different spin models including spin glasses, the Ising model, and the Potts model, lattice protein adsorption, and the self-assembly process in amphiphilic solutions. Without loss of accuracy, the method gives significant speed-up and potentially scales up to petaflop machines.

  20. Sequencing of 15 new BoLA-DRB3 alleles.

    PubMed

    Wang, K; Sun, D; Zhang, Y

    2008-08-01

    The class II DR of bovine major histocompatibility complex of cattle (BoLA) plays a central role in the regulation of the immune response through their ability to present those peptides to T-cell receptors. In this work, we sequenced the exon2 of DRB3 to identify new alleles in Chinese yellow cattle, a total of 15 new BoLA-DRB3 alleles were found.

  1. A Study of BO Lyn, a neglected HADS star

    NASA Astrophysics Data System (ADS)

    Peña, J. H.; Villarreal, C.; Piña, D. S.; Rentería, A.; Guillen, J.; Soni, A. A.; Huepa, H.

    2016-10-01

    uvby-β photometry of the high amplitude δ Scuti (HADS) star BO Lyn allowed us to determine its physical characteristics. A secular period variation was established through the O-C of all the available times of maximum light and those newly acquired through CCD photometry. In the present study we have demonstrated that BO Lyn is pulsating with one stable varying period whose O-C residuals show a sinusoidal pattern compatible with a light-travel time effect.

  2. Comment on ''Sensitivity Analysis and Determination of Streambed Leakance and Aquifer Hydraulic Properties'' by Xunhong Chen and Xi Chen, Journal of Hydrology, 2003, v.284, 270-284

    SciTech Connect

    Kollet, S

    2004-05-17

    Recently, studies of the Platte River watershed have gained significant attention from federal and Nebraska, USA, state agencies due to the importance of groundwater/surface-water interactions under drought conditions. Using archive data from a 1983 pumping test, Chen and Chen (2003) interpret the hydraulic properties of the alluvium and a streambed of the Platte River near Kearney, Nebraska, and compare their data with results of other studies performed over the past several years. Three important inconsistencies of this article will be highlighted here: (1) misuse of the analytical model of Hunt (1999), (2) departure of their results from previously published data, and (3) unsatisfactory explanation of these anomalous results.

  3. [On English translation of jun, chen, zuo and shi in science of prescription].

    PubMed

    Chen, Jin; Zhang, Qing-rong

    2007-10-01

    In this paper, English translation of JUN, CHEN, ZUO, and SHI in science of prescription of traditional Chinese medicine were discussed by hunting the headstream, analyzing and explaining their implication, discriminating and selecting the relative English terms.

  4. Proposed approximation for contact angles in Shan-and-Chen-type multicomponent multiphase lattice Boltzmann models

    NASA Astrophysics Data System (ADS)

    Huang, Haibo; Thorne, Daniel T., Jr.; Schaap, Marcel G.; Sukop, Michael C.

    2007-12-01

    We propose a method for approximating the adhesion parameters in the Shan and Chen multicomponent, multiphase lattice Boltzmann model that leads to the desired fluid-solid contact angle. The method is a straightforward application of Young’s equation with substitution of the Shan and Chen cohesion parameter and a density factor for the fluid-fluid interfacial tension, and the adhesion parameters for the corresponding fluid-solid interfacial tensions.

  5. Recombinant Botulinum Neurotoxin Hc Subunit (BoNT Hc) and Catalytically Inactive Clostridium botulinum Holoproteins (ciBoNT HPs) as Vaccine Candidates for the Prevention of Botulism.

    PubMed

    Webb, Robert P; Smith, Theresa J; Smith, Leonard A; Wright, Patrick M; Guernieri, Rebecca L; Brown, Jennifer L; Skerry, Janet C

    2017-09-03

    There are few available medical countermeasures against botulism and the discontinuation of the pentavalent botulinum toxoid vaccine by the Centers for Disease Control and Prevention in 2011 has resulted in the need for a safe and effective prophylactic alternative. Advances in genetic engineering have resulted in subsequent vaccine efforts being primarily focused on the production of highly purified recombinant protein antigens representing one or more domains of the botulinum neurotoxin. Recombinant subunit vaccines based on the carboxy one-third of the toxin (Hc) developed in our lab against serotypes A-F have been shown to be safe and effective. However, in response to the identification of an ever increasing number of BoNT subtypes with significant amino acid heterogeneity, we have developed catalytically inactive BoNT holoproteins (ciBoNT HPs) in an attempt to elicit greater protective immunity to address these toxin variants. Here we report the production of ciBoNT/B1 HP, ciBoNT/C1 HP, ciBoNT/E1 HP and ciBoNT/F1 HP and compare the immunological and protective abilities of ciBoNT HPs and BoNT/A Hc, BoNT/B Hc, BoNT/C Hc, BoNT/E Hc and BoNT/F Hc vaccines when challenged with homologous and heterologous toxins. Our results suggest the ciBoNT HP vaccines exhibit superior potency after single vaccinations but multiple vaccinations with BoNT/Hc antigens resulted in increased survival rates at the toxin challenge levels used.

  6. Dynamics analysis of fractional order Yu-Wang system

    NASA Astrophysics Data System (ADS)

    Bhalekar, Sachin

    2013-10-01

    Fractional order version of a dynamical system introduced by Yu and Wang (Engineering, Technology & Applied Science Research, 2, (2012) 209-215) is discussed in this article. The basic dynamical properties of the system are studied. Minimum effective dimension 0.942329 for the existence of chaos in the proposed system is obtained using the analytical result. For chaos detection, we have calculated maximum Lyapunov exponents for various values of fractional order. Feedback control method is then used to control chaos in the system. Further, the system is synchronized with itself and with fractional order financial system using active control technique. Modified Adams-Bashforth-Moulton algorithm is used for numerical simulations.

  7. Convergence for the Wang-Landau density of states.

    PubMed

    Brown, G; Odbadrakh, Kh; Nicholson, D M; Eisenbach, M

    2011-12-01

    The Wang-Landau method of estimating the density of states g(E) has become a powerful tool in statistical mechanics. Here it is shown that the distribution of random walkers sampled using an estimated density of states can always be used to improve the estimate. Specifically, this can be done without resorting to an auxiliary modification factor f, which previously has been used to find g(E) self-consistently through a procedure that reduces f incrementally toward unity. This straightforward approach is validated for multiple, independent random walkers.

  8. Wang-Landau Simulations of Adsorbed and Confined Lattice Proteins

    NASA Astrophysics Data System (ADS)

    Pattanasiri, Busara; Li, Ying Wai; Landau, David P.; Wüst, Thomas

    2012-08-01

    The hydrophobic-polar (HP) model has emerged as one of the standard approaches for simulating protein folding. In this work, we used this model together with Wang-Landau (WL) sampling and appropriate Monte Carlo trial moves to determine the density of states and thermodynamics for two cases: Protein adsorption and protein confinement, in the vicinity of attractive surfaces. The influence on the adsorption behavior of surface attractive strength in the adsorption case and volumetric spaces in the confinement case will be discussed.

  9. Microscopic solvation of NaBO2 in water: anion photoelectron spectroscopy and ab initio calculations.

    PubMed

    Feng, Yuan; Cheng, Min; Kong, Xiang-Yu; Xu, Hong-Guang; Zheng, Wei-Jun

    2011-09-21

    We investigated the microscopic solvation of NaBO(2) in water by conducting photoelectron spectroscopy and ab initio studies on NaBO(2)(-)(H(2)O)(n) (n = 0-4) clusters. The vertical detachment energy (VDE) of NaBO(2)(-) is estimated to be 1.00 ± 0.08 eV. The photoelectron spectra of NaBO(2)(-)(H(2)O)(1) and NaBO(2)(-)(H(2)O)(2) are similar to that of bare NaBO(2)(-), except that their VDEs shift to higher electron binding energies (EBE). For the spectra of NaBO(2)(-)(H(2)O)(3) and NaBO(2)(-)(H(2)O)(4), a low EBE feature appears dramatically in addition to the features observed in the spectra of NaBO(2)(-)(H(2)O)(0-2). Our study shows that the water molecules mainly interact with the BO(2)(-) unit in NaBO(2)(-)(H(2)O)(1) and NaBO(2)(-)(H(2)O)(2) clusters to form Na-BO(2)(-)(H(2)O)(n) type structures, while in NaBO(2)(-)(H(2)O)(3) and NaBO(2)(-)(H(2)O)(4) clusters, the water molecules can interact strongly with the Na atom, therefore, the Na-BO(2)(-)(H(2)O)(n) and Na(H(2)O)(n)···BO(2)(-) types of structures coexist. That can be seen as an initial step of the transition from a contact ion pair (CIP) structure to a solvent-separated ion pair (SSIP) structure for the dissolution of NaBO(2).

  10. Level of chemical and microbiological contaminations in chili bo (paste).

    PubMed

    Zaini, Nurul Aqilah Mohd; Harith, Hanis Hazeera; Olusesan, Akanbi Taiwo; Zulkifli, Anwarul Hidayah; Bakar, Fatimah Abu; Osman, Azizah; Hamid, Azizah Abd; Saari, Nazamid

    2010-03-01

    The objective of this study was to determine the level of preservatives and microbiological loads in various brands of commercially available chili bo (paste). Fifteen different brands of chili bo obtained from the local market and hypermarkets were analyzed for pH, moisture and benzoic acid content, microbiological loads (aerobic, anaerobic, aerobic spores, and fungi), and thermophilic microorganisms. Results showed that both moisture content and pH vary among samples. The concentrations of benzoic acid detected in chili bo were found to be in the range of 537 to 5,435 mg/kg. Nine of fifteen brands were found to exceed the maximum level permitted by the Malaysian Food Law in accordance with the Codex Alimentarius (1,000 mg/kg for benzoic acid). An apparent correlation between benzoic acid concentration and microbiological loads present in the chili bo was observed. The microbiological loads were found to be relatively low in the end products containing high amounts of benzoic acid. The heat-resistant (70 to 80 degrees C) microorganisms present in chili bo were identified as Ochrobacterum tritici, Stenotrophomonas rhizophila, Microbacterium maritypicum, Roseomonas spp., CDC group II-E subgroup A, Flavimonas oryzihabitans, and Pseudomonas aeruginosa, with M. maritypicum being the most frequently found (in 9 of 15 samples) microorganism. Most of these identified microorganisms were not known to cause foodborne illnesses.

  11. [Clearing the doubts of all Wang Bing in the Tang dynasty].

    PubMed

    Qiao, H; Qiao, Y; Li, H

    1999-10-01

    The problem is probed on the clues provided by Si ku ti yao zheng (Analysis on Summary of Books in Four Parts). It is claimed that the Wang bing (*) recommended by Wei Kang and that recommended by Yuwen Rong in Yu Jiaxi's work refer to the same person, both are identical to the time of the author of Su wen. Further, the time of the above 2 Wang Bing(s) and the Wang Bing recorded in lie nu zhuan (Biongraphies of chaste women) as the son of Wang Lin, are also overlapped with the time of the author of Su wen. It is possible that they are the same person. However, the details of the Wang Bing mentioned in Lang guan shi zhu ti ming (inscription for Lang guan Stone Pillar) is unknown. Again, it is unlikely that the Wang Bing (*) is the author of Su wen and can be only a farfetched analogy drawn after Su Fu's poet.

  12. The Application of Survey in ER Wang Temple Restituting

    NASA Astrophysics Data System (ADS)

    Shuai, W.; Rong, Z.

    2013-07-01

    Er Wang Temple, in World Heritage Site "Dujiang Weirs and Qingchengshan Mountai", was severely destroyed in Wenchuan earthquake of May 2008. There are several problems at different level in every building, such as structural distortion, foundation displacement, wall fracture, roof damage, etc. The stage was completely collapsed in the earthquake. Tableland the stage situated had a huge crack and slope collapse. This article is for the stage renovation. The survey of damage in earthquake is the basis of Er Wang Temple restituting. Survey including field survey after the earthquake and the measurement and investigation for the remained construction member of the main wood structure. For field survey, the basis of pillars which had not have significantly affects in earthquake could be seem as the reference points for measurement. The investigation of remained main wood construction member, especially the size of the key structures and site and manufacture method of the joints, is the important basis for recovery stage. Our team did our utmost to restore the original appearance of stage in design, materials and craft by various tools, which include measured drawings in different times, old images collection, fine measuring by 3D laser scan, measurement of leftover pieces, logical inference.

  13. Wang-Landau sampling: a criterion for halting the simulations.

    PubMed

    Caparica, A A

    2014-04-01

    In this work we propose a criterion to finish the simulations of the Wang-Landau sampling. Instead of determining a final modification factor for all simulations and every sample size, we investigate the behavior of the temperature of the peak of the specific heat during the simulations and finish them when this value varies below a given limit. As a result, different runs stop at different final modification factors. We show that in place of the temperature of the peak of the specific heat one can adopt alternatively the integrated heat transfer as a reference quantity. We apply this technique to the two-dimensional Ising model and a homopolymer. We verify that for the Ising model the mean order of the final modification factors is roughly the same for all lattice sizes, but for the homopolymer the order of the final modification factors increases with increasing polymer sizes. The results show that the simulations can be halted much earlier than is conventional in Wang-Landau sampling, but manifold finite-size simulations are required in order to obtain accurate results. A brief application to the three-dimensional Ising model is also available.

  14. Growth and characterization of acentric BaHf(BO{sub 3}){sub 2} and BaZr(BO{sub 3}){sub 2}

    SciTech Connect

    Mączka, Mirosław; Szymborska-Małek, Katarzyna; Gągor, Anna; Majchrowski, Andrzej

    2015-05-15

    Growth, single crystal X-ray diffraction, polarized Raman and infrared (IR) studies of BaHf(BO{sub 3}){sub 2} are presented. Raman and IR spectra of polycrystalline BaZr(BO{sub 3}){sub 2} are also reported to facilitate assignment of modes. BaHf(BO{sub 3}){sub 2} borate crystallizes in trigonal system, space group R3c, with lattice parameters: a=5.1540(4) Å, c=33.901(3) Å. It accommodates dolomite-like structure doubled in the c direction, which is built of alternating layers of HfO{sub 6} octahedra and BaO{sub 6} distorted trigonal prisms that are connected through borate groups. The obtained structural as well as spectroscopic data show that BaHf(BO{sub 3}){sub 2} is isostructural with BaZr(BO{sub 3}){sub 2} and the deviations from centrosymmetry is small. - Graphical abstract: Arrangement of BO{sub 3} groups in BaHf(BO{sub 3}){sub 2} along the c direction in one unit cell. Dark and light blue denote different borate groups. - Highlights: • BaHf(BO{sub 3}){sub 2} single crystals were grown. • X-ray diffraction showed that this borate crystallizes in the acentric R3c structure. • Raman and IR spectra were measured for BaHf(BO{sub 3}){sub 2} and BaZr(BO{sub 3}){sub 2}, respectively. • Assignment of modes is proposed.

  15. Ke Wang, a Chinese television soap opera with a message.

    PubMed

    Wang, M; Singhal, A

    1992-01-01

    The Chinese soap opera, Ke Wang, was created by Li Xiaoming between August 1989 and June 1990 and produced at a cost of US$4650 per episode. The characters were drawn from everyday ordinary Chinese life: a traditional and open-minded and caring woman, a typical mother who works hard and loves her children, a highly educated upwardly mobile man who divorces his wife, a professor criticized during the Cultural Revolution, a doctor prejudiced against ordinary people, a kind honest man who marries the divorcee, a friend of the divorcee, a man who is optimistic in spite of bad experiences during the Cultural Revolution, and an excellent medical doctor who also resolves conflicts. The program was very popular, even among Communists, because of its value-based content, the real-life nature of the show, the change from highly restricted programming, the elaborate and supportive media coverage, and dialogue which closely matches audience preferences. The show has been aired by over 100 stations to date and has reached a total estimated audience of 550 million. The sale of television sets has increased since the show's appearance. The script reflects the conflicts between traditional and modern Chinese values. Pro-social values and behaviors are learned from the role models depicted; examples are given of immediate social impact. Ke Wang was a by-product of the Beijing Television Arts Center's interest in designing television programs that are relevant to the lives of ordinary people. The 60-minute scripts dealt with issues such as the status of women, social morality, family harmony, class conflict, responsible parenthood, maintenance of traditional culture, volunteerism, child development, and coping with physical disability. The Chinese government hailed Ke Wang as model television and awarded US$20,000 in prize money to the producers. The Chinese government is planning to produce other entertainment-education soap operas, which raises the problem of blatant, political

  16. Role of bovine herpesvirus type 5 (BoHV-5) in diseases of cattle. Recent findings on BoHV-5 association with genital disease

    PubMed Central

    Favier, P.A.; Marin, M.S.; Pérez, S.E.

    2012-01-01

    Bovine herpesvirus type 5 (BoHV-5) belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. This virus is a major causative agent of non-suppurative meningoencephalitis in young cattle. It was first isolated in 1962 from a neurological disease outbreak in Australia. BoHV-5 is genetically and antigenically related to bovine herpesvirus type 1 (BoHV-1), a highly prevalent virus responsible for respiratory and genital disease in cattle. Initially, BoHV-5 was considered a subtype of BoHV-1 (BoHV-1.3). However, the exclusive presentation of outbreaks of neurological disease suggested that the virus was a new agent with characteristics of neuropathogenicity. Even though both are neurotropic viruses, only BoHV-5 is capable of replicating extensively in the central nervous system and inducing neurological disease. Occasionally, encephalitis caused by BoHV-1 has been reported. Like other alpha-herpesviruses, BoHV-5 can establish latency in nervous ganglia and, by stress factors or glucocorticoid treatment, latent virus can be reactivated. During episodes of reactivation, the virus is excreted in nasal, ocular and genital secretions and transmitted to other susceptible hosts. Recently, BoHV-5 has been associated with infection of the reproductive tract. The virus has been isolated and the presence of viral DNA has been demonstrated in semen samples from Brazil and Australia and natural transmission of the virus through contaminated semen has also been described. Embryos and oocytes are permissive for BoHV-5 infection and BoHV-5 DNA has been detected in the central nervous system of aborted fetuses. The objective of this review is to compile the limited information on the recent association between BoHV-5 and reproductive disorders in cattle. PMID:26623291

  17. Secure Communication Based on Hyperchaotic Chen System with Time-Delay

    NASA Astrophysics Data System (ADS)

    Ren, Hai-Peng; Bai, Chao; Huang, Zhan-Zhan; Grebogi, Celso

    An experimental secure communication method based on the Chen system with time-delay is being proposed in this paper. The Chen system with time-delay is an infinite-dimensional system having more than one positive Lyapunov exponent. The message to be transmitted is encrypted using an hyperchaotic signal generated by the Chen system with time-delay and multishift cipher function. This encryption makes difficult for an eavesdropper to reconstruct the attractor by using time-delay embedding techniques, return map reconstruction, or spectral analysis, consequently, improving the security. Simulations and experiments on TI TMS320C6713 Digital Signal Processor (DSP) show improved resilience against attack and the feasibility of the proposed scheme.

  18. FIRST Robotics, Gulfport High, StenniSphere, Bo Clarke, mentor

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Bo Clarke, mentor for Gulfport High School's Team Fusion, offers strategy tips to students and coaches during the FIRST Robotics Competition kickoff held at StenniSphere on Jan. 7. Clarke is the lead building and infrastructure specialist for NASA's Shared Services Center at Stennis Space Center.

  19. AmeriFlux US-Bo2 Bondville (companion site)

    DOE Data Explorer

    Bernacchi, Carl [University of Illinois, Urbana-Champaign

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Bo2 Bondville (companion site). Site Description - Located 400m north of Tilden Meyer's site and planted with opposite crop in corn/soybean rotation

  20. FIRST Robotics, Gulfport High, StenniSphere, Bo Clarke, mentor

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Bo Clarke, mentor for Gulfport High School's Team Fusion, offers strategy tips to students and coaches during the FIRST Robotics Competition kickoff held at StenniSphere on Jan. 7. Clarke is the lead building and infrastructure specialist for NASA's Shared Services Center at Stennis Space Center.

  1. AmeriFlux US-Bo1 Bondville

    SciTech Connect

    Meyers, Tilden

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Bo1 Bondville. Site Description - Agriculture, continuous no-till since 1986, Annual rotation between corn (C4) and soybeans (C3). The field was planted with corn during 2005 and 2007, with soybeans during 2006 and 2008.

  2. FIRST Robotics, Gulfport High, StenniSphere, Bo Clarke, mentor

    NASA Image and Video Library

    2006-01-07

    Bo Clarke, mentor for Gulfport High School's Team Fusion, offers strategy tips to students and coaches during the FIRST Robotics Competition kickoff held at StenniSphere on Jan. 7. Clarke is the lead building and infrastructure specialist for NASA's Shared Services Center at Stennis Space Center.

  3. Multiple Walkers in the Wang-Landau Algorithm

    SciTech Connect

    Brown, G

    2005-12-28

    The mean cost for converging an estimated density of states using the Wang-Landau algorithm is measured for the Ising and Heisenberg models. The cost increases in a power-law fashion with the number of spins, with an exponent near 3 for one-dimensional models, and closer to 2.4 for two-dimensional models. The effect of multiple, simultaneous walkers on the cost is also measured. For the one-dimensional Ising model the cost can increase with the number of walkers for large systems. For both the Ising and Heisenberg models in two-dimensions, no adverse impact on the cost is observed. Thus multiple walkers is a strategy that should scale well in a parallel computing environment for many models of magnetic materials.

  4. Generic parallel Wang-Landau sampling for complex systems

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Vogel, Thomas; Landau, David P.; Wüst, Thomas

    2013-03-01

    We introduce a parallel realization for Wang-Landau sampling in Monte Carlo simulations based on a replica-exchange framework. The key idea is to split the entire energy range of the system under consideration into several smaller, overlapping sub intervals. The survey of configurational phase space can then be distributed over multiple processors, with exchanges of random walkers taking place in the overlapping energy windows. To demonstrate the robustness and advantages of this parallel scheme for the simulations of complex systems, we have applied it to protein adsorption problems using the HP lattice protein model[1]. The method gives significant speed-up and achieves strong scaling on small computer architectures like multi-core processors, with a possible improvement in accuracy. We believe that it could be potentially beneficial for large-scale petaflop machines.

  5. Wang-Landau Monte Carlo formalism applied to ferroelectrics

    NASA Astrophysics Data System (ADS)

    Bin-Omran, S.; Kornev, Igor A.; Bellaiche, L.

    2016-01-01

    The Wang-Landau Monte Carlo algorithm is implemented within an effective Hamiltonian approach and applied to BaTiO3 bulk. The density of states obtained by this approach allows a highly accurate and straightforward calculation of various thermodynamic properties, including phase transition temperatures, as well as polarization, dielectric susceptibility, specific heat, and electrocaloric coefficient at any temperature. This approach yields rather smooth data even near phase transitions and provides direct access to entropy and free energy, which allow us to compute properties that are typically unaccessible by atomistic simulations. Examples of such latter properties are the nature (i.e., first order versus second order) of the phase transitions for different supercell sizes and the thermodynamic limit of the Curie temperature and latent heat.

  6. Scalable replica-exchange framework for Wang-Landau sampling.

    PubMed

    Vogel, Thomas; Li, Ying Wai; Wüst, Thomas; Landau, David P

    2014-08-01

    We investigate a generic, parallel replica-exchange framework for Monte Carlo simulations based on the Wang-Landau method. To demonstrate its advantages and general applicability for massively parallel simulations of complex systems, we apply it to lattice spin models, the self-assembly process in amphiphilic solutions, and the adsorption of molecules on surfaces. While of general current interest, the latter phenomena are challenging to study computationally because of multiple structural transitions occurring over a broad temperature range. We show how the parallel framework facilitates simulations of such processes and, without any loss of accuracy or precision, gives a significant speedup and allows for the study of much larger systems and much wider temperature ranges than possible with single-walker methods.

  7. Improving Wang-Landau sampling with adaptive windows.

    PubMed

    Cunha-Netto, A G; Caparica, A A; Tsai, Shan-Ho; Dickman, Ronald; Landau, D P

    2008-11-01

    Wang-Landau sampling (WLS) of large systems requires dividing the energy range into "windows" and joining the results of simulations in each window. The resulting density of states (and associated thermodynamic functions) is shown to suffer from boundary effects in simulations of lattice polymers and the five-state Potts model. Here, we implement WLS using adaptive windows. Instead of defining fixed energy windows (or windows in the energy-magnetization plane for the Potts model), the boundary positions depend on the set of energy values on which the histogram is flat at a given stage of the simulation. Shifting the windows each time the modification factor f is reduced, we eliminate border effects that arise in simulations using fixed windows. Adaptive windows extend significantly the range of system sizes that may be studied reliably using WLS.

  8. Wang-Landau simulations of polymer adsorption on diluted surfaces

    NASA Astrophysics Data System (ADS)

    Martins, Paulo; Vogel, Thomas; Landau, David

    2012-02-01

    We consider a single linear lattice homopolymer in three dimensions that interacts with a diluted planar surface. A fraction p of the total number of the sites on the substrate is attractive, while the remaining 1-p remains neutral. Our focus is on the conformational transitions the polymer can experience under different environmental conditions, for instance, the surface dilution and the strength of the substrate attraction, compared to the intensity of the monomer-monomer interactions. To get insights on the phase diagram we have performed extensive Monte Carlo simulations, by using the Wang-Landau sampling, for different values of the surface attraction ɛ and the concentration of attractive sites p, specially near the surface percolation threshold pc.

  9. Scalable replica-exchange framework for Wang-Landau sampling

    NASA Astrophysics Data System (ADS)

    Vogel, Thomas; Li, Ying Wai; Wüst, Thomas; Landau, David P.

    2014-08-01

    We investigate a generic, parallel replica-exchange framework for Monte Carlo simulations based on the Wang-Landau method. To demonstrate its advantages and general applicability for massively parallel simulations of complex systems, we apply it to lattice spin models, the self-assembly process in amphiphilic solutions, and the adsorption of molecules on surfaces. While of general current interest, the latter phenomena are challenging to study computationally because of multiple structural transitions occurring over a broad temperature range. We show how the parallel framework facilitates simulations of such processes and, without any loss of accuracy or precision, gives a significant speedup and allows for the study of much larger systems and much wider temperature ranges than possible with single-walker methods.

  10. Improving Wang-Landau sampling with adaptive windows

    NASA Astrophysics Data System (ADS)

    Cunha-Netto, A. G.; Caparica, A. A.; Tsai, Shan-Ho; Dickman, Ronald; Landau, D. P.

    2008-11-01

    Wang-Landau sampling (WLS) of large systems requires dividing the energy range into “windows” and joining the results of simulations in each window. The resulting density of states (and associated thermodynamic functions) is shown to suffer from boundary effects in simulations of lattice polymers and the five-state Potts model. Here, we implement WLS using adaptive windows. Instead of defining fixed energy windows (or windows in the energy-magnetization plane for the Potts model), the boundary positions depend on the set of energy values on which the histogram is flat at a given stage of the simulation. Shifting the windows each time the modification factor f is reduced, we eliminate border effects that arise in simulations using fixed windows. Adaptive windows extend significantly the range of system sizes that may be studied reliably using WLS.

  11. [The textual research on the medical work of Wang tao].

    PubMed

    Song, Zhen-min

    2009-03-01

    Wang tao began to learn TCM as soon as he grew up, his teachers were proficient and famous doctors. He traveled and learned from them for several times and grasped their medical thoughts and technologies, therefore achieved profound medical accomplishments. Taking advantage of his medical background and occupation, he collected fifty and sixty kinds of medical data in prescription books of Jin and Tang dynasty from treasured books of Hong wen museum in Tianbao fifth to sixth years (746 -747) , when he served as Jishizhong of Ministry of Counseling and Functionary Management and administrated Hongwen museum. He then sorted them and compiled the famous work: Waitai Miyao (Arcane Essentials from the Imperial Library) in Tianbao 11th year (752).

  12. Bridge No. 1396, Fourth Potomac and Second B&O Crossing, with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bridge No. 1396, Fourth Potomac and Second B&O Crossing, with B&O Potomac Crossing (built ca. 1914 as part of B&O's Magnolia Cutoff) in background, looking east. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  13. Rapid detection of BoHV-1 genomic DNA by loop-mediated isothermal amplification assay.

    PubMed

    El-Kholy, Alaa A; Abdelrahman, Khaled; Soliman, Hatem

    2014-08-01

    Bovine herpes virus-1 (BoHV-1) is a serious viral pathogen of domestic and wild cattle. Herein, we report development of a new molecular diagnostic assay for rapid and sensitive detection of BoHV-1 utilizing the loop-mediated isothermal amplification (LAMP) technique. BoHV-1-LAMP assay was optimized to amplify the target DNA by incubation the Bst-DNA polymerase enzyme with a set of specially constructed six primers, based on the gE-gene of BoHV-1 virus, at 65°C for 60min. BoHV-1-LAMP products were detected by visual inspection using SYBR Green-I stain and had a ladder-like appearance by gel electrophoresis analysis. Negative results obtained with DNA from other tested fish viruses confirmed the specificity of the assay. The analytical sensitivity of the BoHV-1-LAMP assay was 1fg of BoHV-1 DNA (dilution of 10(6)). The developed assay could successfully detect BoVH-1 DNA from clinical samples. Results of this study indicate that the developed BoHV-1-LAMP is rapid and highly sensitive assay not only for detection of BoHV-1 in clinical samples, but also for differentiation between wild-type (gE-positive) and gE-negative BoHV-1 viruses, which will improve the control programs of BoHV-1 in Egypt.

  14. A new piecewise linear Chen system of fractional-order: Numerical approximation of stable attractors

    NASA Astrophysics Data System (ADS)

    Danca, Marius-F.; Aziz-Alaoui, M. A.; Small, Michael

    2015-06-01

    In this paper we present a new version of Chen’s system: a piecewise linear (PWL) Chen system of fractional-order. Via a sigmoid-like function, the discontinuous system is transformed into a continuous system. By numerical simulations, we reveal chaotic behaviors and also multistability, i.e., the existence of small parameter windows where, for some fixed bifurcation parameter and depending on initial conditions, coexistence of stable attractors and chaotic attractors is possible. Moreover, we show that by using an algorithm to switch the bifurcation parameter, the stable attractors can be numerically approximated. Dedicated to Professor Chen Guan-Rong on the occasion of his 65th birthday.

  15. Notes on Metaphiremultitheca (Chen, 1938) (Oligochaeta, Megascolecidae) recorded from Vietnam, with descriptions of two new species.

    PubMed

    Nguyen, Anh D; Nguyen, Tung T

    2015-01-01

    The paper deals with Pheretimamultithecamultitheca Chen, 1938 recorded from Vietnam (non Pheretimamultitheca Chen, 1938 now in Metaphire from Hainan Island). As a result, a new species, Amynthaserroneous sp. n., is revealed from materials which were previously misidentified as Pheretimamultithecamultitheca. The new species is obviously distinguished from other Amynthas species by multiple spermathecal pores lateroventral in intersegments 5/6/7/8/9, and presence of two pairs of crescentic genital markings in xviii. In addition, another new species, Amynthasnhonmontis sp. n., is described and easily recognized by multiple spermathecal pores ventral in intersegments 5/6/7/8 and three pairs of genital markings in xvii, xix and xx.

  16. Communicating between the IBM Personal Computer and the Wang word-processing system

    SciTech Connect

    Downey, R.M.

    1983-09-07

    This manual outlines the steps for transferring documents to a Wang word processor from an IBM Personal Computer (PC) and for retrieving stored documents from the Wang. We first look at hardware and software needed to connect the two systems before detailing the steps to take in transferring a document.

  17. Phonology and Reading: A Response to Wang, Trezek, Luckner, and Paul

    ERIC Educational Resources Information Center

    Allen, Thomas E.; Clark, M. Diane; del Giudice, Alex; Koo, Daniel; Lieberman, Amy; Mayberry, Rachel; Millerd, Paul

    2009-01-01

    Four critical responses to an article, "The Role of Phonology and Phonologically Related Skills in Reading Instruction for Students Who Are Deaf or Hard of Hearing" (Wang, Trezek, Luckner, & Paul, 2008), are presented. Issue is taken with the conclusions of the article by Wang and colleagues regarding the "necessary" condition of phonological…

  18. FORTRAN IV Compiler-Loader for the Wang 520/600 Calculator

    DTIC Science & Technology

    1976-03-01

    This paper describes a compiler system that will translate FORTRAN IV programs into programs that will run on the Wang 520/600 programmable ... calculator . The system includes an option to generate the Wang programs on punched cards that can be input into the 520 or 600 via a mark-sense card reader

  19. VizieR Online Data Catalog: LAMOST survey of star clusters in M31. II. (Chen+, 2016)

    NASA Astrophysics Data System (ADS)

    Chen, B.; Liu, X.; Xiang, M.; Yuan, H.; Huang, Y.; Shi, J.; Fan, Z.; Huo, Z.; Wang, C.; Ren, J.; Tian, Z.; Zhang, H.; Liu, G.; Cao, Z.; Zhang, Y.; Hou, Y.; Wang, Y.

    2016-09-01

    We select a sample of 306 massive star clusters observed with the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST) in the vicinity fields of M31 and M33. Massive clusters in our sample are all selected from the catalog presented in Paper I (Chen et al. 2015, Cat. J/other/RAA/15.1392), including five newly discovered clusters selected with the SDSS photometry, three newly confirmed, and 298 previously known clusters from Revised Bologna Catalogue (RBC; Galleti et al. 2012, Cat. V/143; http://www.bo.astro.it/M31/). Since then another two objects, B341 and B207, have also been observed with LAMOST, and they are included in the current analysis. The current sample does not include those listed in Paper I but is selected from Johnson et al. 2012 (Cat. J/ApJ/752/95) since most of them are young but not so massive. All objects are observed with LAMOST between 2011 September and 2014 June. Table1 lists the name, position, and radial velocity of all sample clusters analyzed in the current work. The LAMOST spectra cover the wavelength range 3700-9000Å at a resolving power of R~1800. Details about the observations and data reduction can be found in Paper I. The median signal-to-noise ratio (S/N) per pixel at 4750 and 7450Å of spectra of all clusters in the current sample are, respectively, 14 and 37. Essentially all spectra have S/N(4750Å)>5 except for the spectra of 18 clusters. The latter have S/N(7540Å)>10. Peacock et al. 2010 (Cat. J/MNRAS/402/803) retrieved images of M31 star clusters and candidates from the SDSS archive and extracted ugriz aperture photometric magnitudes from those objects using the SExtractor. They present a catalog containing homogeneous ugriz photometry of 572 star clusters and 373 candidates. Among them, 299 clusters are in our sample. (2 data files).

  20. Luminescence study of Dy or Ce activated LiCaBO3 phosphor for γ-ray and C5+ ion beam irradiation.

    PubMed

    Oza, Abha H; Dhoble, N S; Lochab, S P; Dhoble, S J

    2015-11-01

    The photoluminescence and thermoluminescence characteristics of rare earths (Dy or Ce) activated LiCaBO3 phosphors have been studied. Phosphors were synthesized by modified solid state synthesis. The phosphors were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), photoluminescence (PL) and thermoluminescence (TL) for structural, morphological and luminescence studies. Dy(3+) activated LiCaBO3 shows emission at 486 and 577 nm due to (4) F9/2 →(6) H15/2 and (4) F9/2 → (6) H13/2 transition, respectively, whereas the PL emission spectra of Ce(3+) activated LiCaBO3 phosphor shows a broad band peaking at 432 nm, which is due to the transition from 5d level to the ground state of the Ce(3+) ion. The thermoluminescence study was also carried out for both these phosphors for γ-ray irradiation and carbon beam irradiation. Linearity was studied for a 0.4-3.1 Rad dose γ-rays. Linear behaviour over this dose range was observed. Gamma ray-irradiated phosphors were shown to be negligible fading upon storage. All the samples were also studied for 75 MeV C(5+) ion beam exposure in the range of 3.75 × 10(12) - 7.5 × 10(13) ion cm(-2) fluence. In addition to this, trapping parameters of all the samples were also calculated using Chen's peak shape method. Copyright © 2015 John Wiley & Sons, Ltd.

  1. New polymorphisms for the BoLA-DRB3 upstream regulatory region.

    PubMed

    Ripoli, M V; Villegas-Castagnasso, E E; Peral-Garcia, P; Giovambattista, G

    2005-08-01

    Two new alleles, named BoLA-DRB3-P*06 and BoLA-DRB3-P*07, have been identified for the upstream regulatory region of the BoLA-DRB3 gene. The 228-bp nucleotide sequences of the promoter comprising the W, X, Y, CAAT and TATA regulatory boxes were analysed. The BoLA-DRB3-P*06 exhibits one insertion between the W and X boxes, and one transition between the X and Y boxes. On the other hand, the BoLA-DRB3-P*07 showed one insertion in the X box.

  2. On the Prediction of Separation Bubbles Using a Modified Chen-Thyson Model

    NASA Technical Reports Server (NTRS)

    Platzer, Max F.; Ekaterinaris, John A.; Chandrasekhara, M. S.

    2007-01-01

    The prediction of separation bubbles on NACA 65-213 and NACA 0012 using a modified Chen-Thyson transition model is presented. The contents include: 1) Background; 2) Analysis of NACA 65-213 separation bubble using cebeci's viscous-inviscid interaction method; 3) Analysis of NACA 0012 separation bubble using navier-stokes method; and 4) Comparison with experiment.

  3. Establishment of a sequence-based typing system for BoLA-DQA1 exon 2.

    PubMed

    Takeshima, S; Miki, A; Kado, M; Aida, Y

    2007-02-01

    In cattle, bovine leukocyte antigens (BoLAs) have been extensively used as markers for bovine diseases and immunological traits. Here, we developed a rapid, high-resolution sequence-based typing (SBT) system for BoLA-DQA1. We amplified 355 bp of BoLA-DQA1 by fully nested polymerase chain reaction (PCR) using the newly constructed primers and then performed direct sequencing of each product. Using this method, we investigated the locus in 51 animals whose BoLA haplotypes had been characterized at the Fifth International BoLA Workshop. We identified 15 distinct DQA1 alleles, and there is no conflict between the typing result of PCR-SBT and restriction fragment length polymorphism analysis. Together with the previously developed method for typing BoLA-DRB3, the PCR-SBT for BoLA-DQA1 clearly provides a useful tool for detailed class IIa haplotype analysis.

  4. The brightest of reionizing galaxies (BoRG) survey

    NASA Astrophysics Data System (ADS)

    Trenti, Michele

    2012-09-01

    Until now, investigating the early stages of galaxy formation has been primarily the realm of theoretical modeling and computer simulations, which require many physical ingredients and are challenging to test observationally. However, the latest Hubble Space Telescope observations in the near infrared are shedding new light on the properties of galaxies within the first billion years after the Big Bang, including our recent discovery of the most distant proto-cluster of galaxies at redshift z ~ 8. Here, I compare predictions from models of primordial and metal-enriched star formation during the dark ages with the latest Hubble observations of galaxies during the epoch of reionization. I focus in particular on the luminosity function and on galaxy clustering as measured from our Hubble Space Telescope Brightest of Reionizing Galaxies (BoRG) survey. BoRG has the largest area coverage to find luminous and rare z ~ 8 sources that are among the first galaxies to have formed in the Universe.

  5. The BoNuS Experiment At Jefferson Lab

    SciTech Connect

    Stephen Baltmann

    2005-02-01

    The BoNuS experiment at Jefferson Lab's Hall B is going to measure the structure of the quasi-free neutron via electron scattering off a deuteron target and detection of the slowly recoiling spectator proton at very backward angles. To detect the low momentum backward recoiling protons, the CLAS detector will be augmented with a novel radial time projection chamber featuring gas electron multipliers. Data taking is anticipated for 2005 or 2006.

  6. FIASCO, VoxBo, and MEDx: behind the code.

    PubMed

    Aguirre, Geoffrey K

    2012-08-15

    The early years of BOLD fMRI coincided with the rapid growth of both the internet and the open-source software movement. This environment encouraged the creation and dissemination of many neuroimaging software projects, only some of which survived. I tell the story of two of these open-source projects, FIASCO and VoxBo, as well as the interesting links between the commercial MedX software deployed at the NIH and satellite reconnaissance.

  7. [Mr. Wang Le-ting: a master of acupuncture].

    PubMed

    Niu, Xue-Song; Wang, Fan

    2012-11-01

    Mr. WANG Le-ting attaches great importance to accurate differentiation of syndromes, strict selection of acupoints, technique and direction of needle insertion, clear reinforcing and reducing methods after the appearance of needling sensations, proper opportunities of manipulations as well as needle withdrawal techniques, and reasonable application of acupuncture and moxibustion respectively. The above mentioned principles are known as his "5 agreements". He emphasizes that the selection of acupoints should be "in accordance with both the meridians and the accurate location of the points", and "needling sensation is necessary for each point". He holds that the back-shu points of the five-zang organs and Geshu (BL 17) can be adopted for patient with deficiency of qi, blood, yin and yang. In the aspect of acupoint theory, he insists the accurate location of Xuanzhong (GB 39). He also adjusts the locations of Huatuo Jiaji (EX-B 2) points, and finds the location of the new Dubi (ST 35). For easier applications, he divides the functions of acupoints into different schools of qi, blood, cold, heat, deficiency, excess, wind and dampness. And 41 combinations of acupoints are also invented as innovation. He is always strict to his students, instructing and influencing them by his own words and deeds. He is always conscientious and meticulous, which benefit immensely his followers, and remains a lot of precious experiences for the later generations.

  8. Exploring HP protein models using Wang-Landau sampling

    NASA Astrophysics Data System (ADS)

    Wuest, Thomas; Landau, David P.

    2008-03-01

    The hydrophobic-polar (HP) protein model has become a standard in assessing the efficiency of computational methods for protein structure prediction as well as for exploring the statistical physics of protein folding in general. Numerous methods have been proposed to address the challenges of finding minimal energy conformations within the rough energy landscape of this lattice heteropolymer model. However, only a few studies have been dedicated to the more revealing - but also more demanding - problem of estimating the density of states which allows access to thermodynamic properties of a system at any temperature. Here, we show that Wang-Landau sampling, in connection with a suitable move set (``pull moves''), provides a powerful route for the ground state search and the precise determination of the density of states for HP sequences (with up to 100 monomers) in both, two and three dimensions. Our procedure possesses an intrinsic simplicity and overcomes the inevitable limitations inherent in other more tailored approaches. The main advantage lies in its general applicability to a broad range of lattice protein models that go beyond the scope of the HP model.

  9. Water quality associated public health risk in Bo, Sierra Leone.

    PubMed

    Jimmy, David H; Sundufu, Abu J; Malanoski, Anthony P; Jacobsen, Kathryn H; Ansumana, Rashid; Leski, Tomasz A; Bangura, Umaru; Bockarie, Alfred S; Tejan, Edries; Lin, Baochuan; Stenger, David A

    2013-01-01

    Human health depends on reliable access to safe drinking water, but in many developing countries only a limited number of wells and boreholes are available. Many of these water resources are contaminated with biological or chemical pollutants. The goal of this study was to examine water access and quality in urban Bo, Sierra Leone. A health census and community mapping project in one neighborhood in Bo identified the 36 water sources used by the community. A water sample was taken from each water source and tested for a variety of microbiological and physicochemical substances. Only 38.9% of the water sources met World Health Organization (WHO) microbial safety requirements based on fecal coliform levels. Physiochemical analysis indicated that the majority (91.7%) of the water sources met the requirements set by the WHO. In combination, 25% of these water resources met safe drinking water criteria. No variables associated with wells were statistically significant predictors of contamination. This study indicated that fecal contamination is the greatest health risk associated with drinking water. There is a need to raise hygiene awareness and implement inexpensive methods to reduce fecal contamination and improve drinking water safety in Bo, Sierra Leone.

  10. Phonology and reading: a response to Wang, Trezek, Luckner, and Paul.

    PubMed

    Allen, Thomas E; Clark, M Diane; del Giudice, Alex; Koo, Daniel; Lieberman, Amy; Mayberry, Rachel; Miller, Paul

    2009-01-01

    Four critical responses to an article, "The Role of Phonology and Phonologically Related Skills in Reading Instruction for Students Who Are Deaf or Hard of Hearing" (Wang, Trezek, Luckner, & Paul, 2008), are presented. Issue is taken with the conclusions of the article by Wang and colleagues regarding the "necessary" condition of phonological awareness for the development of reading skills among deaf readers. Research findings (not cited by Wang and colleagues) are pointed out that reveal weak correlations between phonemic awareness and reading comprehension, and stronger correlations between other variables such as overall language skill and early exposure to a visual language.

  11. Epidemiologically non-feasible singleton reactors at the final stage of BoHV1 eradication: serological evidence of BoHV2 cross-reactivity.

    PubMed

    Böttcher, Jens; Boje, Jennifer; Janowetz, Britta; Alex, Michaela; König, Patricia; Hagg, Maria; Götz, Franz; Renner, Konrad; Otterbein, Christian; Mages, Johann; Meier, Norbert; Wittkowski, Gerhard

    2012-10-12

    A voluntary marker-independent Bovine Herpesvirus 1 (BoHV1) eradication program started in 1986; in 1998 it changed to a compulsory one. Certification of free regions in European member states is based on Article 10 of directive 64/432/EEC. According to this rule Bavaria is listed as free of BoHV1 since October 2011. Surveillance of BoHV1-free dairy cattle farms is currently performed with quarterly bulk-milk testing. Non-negative bulk-milk results must be confirmed by blood tests in cattle older than nine months. An increased regional rate of non-negative bulk-milk samples and the subsequent detection of epidemiologically non-feasible singleton BoHV1-reactors by analysis of blood were observed at the final stage of eradication in southwest Bavaria. Nineteen case farms (734 animals) defined by singleton reactors born at least two years after certification of the farms as BoHV1-free, 23 negative control (NC) farms (NC I: 321 animals) from the same region, 11 NC-farms (NC II: 423 animals) from an already-certified Article 10 region in northeast Bavaria and two BoHV1-infected farms (264 animals) were analysed using BoHV1-, BoHV2- and Feline Herpesvirus 1 (FeHV1)-neutralisation tests (NTs), and three commercially available ELISAs supplied by Idexx Laboratories, B.V., The Netherlands: the CHEKIT™ Trachitest 2nd Gen. test for milk or serum (Trachitest), Herdchek™ gB- (gB-ELISA) and Herdchek™ gE-ELISA (gE-ELISA). Significantly increased levels of BoHV2 antibodies were observed on case farms compared to NC I or II farms. Additionally, reactivity by gB-ELISA and the Trachitest was significantly increased for animals with BoHV2 neutralising antibodies. Singleton BoHV1-reactors tested negative by gE-ELISA even if an elevated cut-off of 0.95±0.05 was applied. At this cut-off, the gE-ELISA was as sensitive and specific as the gB-ELISA. Comparative titration of milk samples from seropositive animals from a BoHV1-infected dairy cattle farm and from singleton BoHV1-reactors

  12. Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells.

    PubMed

    Chu, Pei-Ming; Chen, Li-Hsin; Chen, Ming-Teh; Ma, Hsin-I; Su, Tsann-Long; Hsieh, Pei-Chen; Chien, Chian-Shiu; Jiang, Bo-Hua; Chen, Yu-Chih; Lin, Yi-Hui; Shih, Yang-Hsin; Tu, Pang-Hsien; Chiou, Shih-Hwa

    2012-03-01

    BO-1051 is an N-mustard derivative that is conjugated with DNA-affinic 9-anilinoacridine. Since BO-1051 was reported to have strong anticancer activity, we investigated the effect and underlying mechanism of BO-1051 in human glioma cell lines. Human glioma cell lines U251MG and U87MG were studied with BO-1051 or the combination of BO-1051 and autophagic inhibitors. Growth inhibition was assessed by MTT assay. Apoptosis was measured by annexin V staining followed by flow cytometry and immunoblotting for apoptosis-related molecules. Induction of autophagy was detected by acridine orange labeling, electron microscopy, LC3 localization and its conversion. Transfection of shRNA was used to determine the involvement of Beclin1 in apoptotic cell death. MTT assay showed that BO-1051 suppressed the viability of four glioma cell lines (U251MG, U87MG, GBM-3 and DBTRG-05MG) in a dose-dependent manner. The IC(50) values of BO-1051 for the glioma cells were significantly lower than the values for primary neurons cultures and normal fibroblast cells. Moreover, BO-1051 not only induced apoptotic cell death, but also enhanced autophagic flux via inhibition of Akt/mTOR and activation of Erk1/2. Importantly, suppression of autophagy by 3-methyladenine or bafilomycin A1 significantly increased BO-1051-induced apoptotic cell death in U251MG and U87MG cells. In addition, the proportion of apoptotic cells after BO-1051 treatment was enhanced by co-treatment with shRNA against Beclin1. BO-1051 induced both apoptosis and autophagy, and inhibition of autophagy significantly augmented the cytotoxic effect of BO-1051. Thus, a combination of BO-1051 and autophagic inhibitors offers a potentially new therapeutic modality for the treatment of malignant glioma.

  13. Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays

    PubMed Central

    Dunning, F. Mark; Piazza, Timothy M.; Zeytin, Füsûn N.; Tucker, Ward C.

    2014-01-01

    Accurate detection and quantification of botulinum neurotoxin (BoNT) in complex matrices is required for pharmaceutical, environmental, and food sample testing. Rapid BoNT testing of foodstuffs is needed during outbreak forensics, patient diagnosis, and food safety testing while accurate potency testing is required for BoNT-based drug product manufacturing and patient safety. The widely used mouse bioassay for BoNT testing is highly sensitive but lacks the precision and throughput needed for rapid and routine BoNT testing. Furthermore, the bioassay's use of animals has resulted in calls by drug product regulatory authorities and animal-rights proponents in the US and abroad to replace the mouse bioassay for BoNT testing. Several in vitro replacement assays have been developed that work well with purified BoNT in simple buffers, but most have not been shown to be applicable to testing in highly complex matrices. Here, a protocol for the detection of BoNT in complex matrices using the BoTest Matrix assays is presented. The assay consists of three parts: The first part involves preparation of the samples for testing, the second part is an immunoprecipitation step using anti-BoNT antibody-coated paramagnetic beads to purify BoNT from the matrix, and the third part quantifies the isolated BoNT's proteolytic activity using a fluorogenic reporter. The protocol is written for high throughput testing in 96-well plates using both liquid and solid matrices and requires about 2 hr of manual preparation with total assay times of 4-26 hr depending on the sample type, toxin load, and desired sensitivity. Data are presented for BoNT/A testing with phosphate-buffered saline, a drug product, culture supernatant, 2% milk, and fresh tomatoes and includes discussion of critical parameters for assay success. PMID:24638074

  14. Photometric metallicities in Boötes I

    NASA Astrophysics Data System (ADS)

    Hughes, J.; Wallerstein, G.; Dotter, A.; Geisler, D.

    2014-03-01

    We present new Strömgren and Washington data sets for the Boötes I dwarf galaxy, and combine them with the available Sloan Digital Sky Survey photometry. The goal of this project is to refine a ground-based, practical, accurate method to determine age and metallicity for individual stars in Boötes I that can be selected in an unbiased imaging survey, without having to take spectra. With few bright upper red giant branch stars and distances of about 35-250 kpc, the ultra-faint dwarf galaxies (UDFs) present observational challenges in characterizing their stellar population. Other recent studies have produced spectra and proper motions, making Boötes I an ideal test case for our photometric methods. We produce photometric metallicities from Strömgren and Washington photometry, for stellar systems with a range of -1.0 > [Fe/H] > -3.5. Needing to avoid the collapse of the metallicity sensitivity of the Strömgren m1-index on the lower red giant branch, we replace the Strömgren v filter with the broader Washington C filter to minimize observing time. We construct two indices: m* = (C - T1)0 - (T1 - T2)0 and m** = (C - b)0 - (b - y)0. We find that CT1by is the most successful filter combination, for individual stars with [Fe/H] < -2.0, to maintain ˜0.2 dex [Fe/H]-resolution over the whole red giant branch. The m**-index would be the best choice for space-based observations because the (C - y) colour is not sufficient to fix metallicity alone in an understudied system. Our photometric metallicites of stars in the central regions of Boötes I confirm that there is a metallicity spread of at least -1.9 > [Fe/H] > -3.7. The best-fitting Dartmouth isochrones give a mean age, for all the Boötes I stars in our data set, of 11.5 ± 0.4 Gyr. From ground-based telescopes, we show that the optimal filter combination is CT1by, avoiding the v filter entirely. We demonstrate that we can break the isochrones' age-metallicity degeneracy with the CT1by filters, using stars with

  15. Free energy computations employing Jarzynski identity and Wang – Landau algorithm

    SciTech Connect

    Kalyan, M. Suman; Murthy, K. P. N.; Sastry, V. S. S.

    2016-05-23

    We introduce a simple method to compute free energy differences employing Jarzynski identity in conjunction with Wang – Landau algorithm. We demonstrate this method on Ising spin system by comparing the results with those obtained from canonical sampling.

  16. Generalizing Swendsen-Wang to sampling arbitrary posterior probabilities.

    PubMed

    Barbu, Adrian; Zhu, Song-Chun

    2005-08-01

    Many vision tasks can be formulated as graph partition problems that minimize energy functions. For such problems, the Gibbs sampler provides a general solution but is very slow, while other methods, such as Ncut and graph cuts are computationally effective but only work for specific energy forms and are not generally applicable. In this paper, we present a new inference algorithm that generalizes the Swendsen-Wang method to arbitrary probabilities defined on graph partitions. We begin by computing graph edge weights, based on local image features. Then, the algorithm iterates two steps. 1) Graph clustering: It forms connected components by cutting the edges probabilistically based on their weights. 2) Graph relabeling: It selects one connected component and flips probabilistically, the coloring of all vertices in the component simultaneously. Thus, it realizes the split, merge, and regrouping of a "chunk" of the graph, in contrast to Gibbs sampler that flips a single vertex. We prove that this algorithm simulates ergodic and reversible Markov chain jumps in the space of graph partitions and is applicable to arbitrary posterior probabilities or energy functions defined on graphs. We demonstrate the algorithm on two typical problems in computer vision--image segmentation and stereo vision. Experimentally, we show that it is 100-400 times faster in CPU time than the classical Gibbs sampler and 20-40 times faster then the DDMCMC segmentation algorithm. For stereo, we compare performance with graph cuts and belief propagation. We also show that our algorithm can automatically infer generative models and obtain satisfactory results (better than the graphic cuts or belief propagation) in the same amount of time.

  17. Robust adaptive synchronization of Rossler and Chen chaotic systems via slide technique

    NASA Astrophysics Data System (ADS)

    Li, Zhi; Shi, Songjiao

    2003-05-01

    This Letter considers the robust adaptive synchronization problem of Rossler and Chen chaotic systems with different time-varying unknown parameters. When system's unknown parameters vary in bound intervals and the bounds of intervals are unknown, a robust adaptive controller is designed. In order to increase the robustness of the closed loop systems, the key idea is that a sliding mode type of controller is employed. Besides, instead of the estimate values of systems' unknown parameters being taken as updating object, a new updating object is introduced in constructing controller. The proposed controller can make the states of Rossler and Chen chaotic systems globally asymptotically robustly synchronized. Simulation results are given to show the effectiveness of the proposed method.

  18. [Mr. Chen Ying-long of chengjiang acupuncture school: a brief introduction].

    PubMed

    Zhu, An-Ning; Zhang, Jian-Bin; Sun, Xiao-Zhong; Meng, Xian-Jun

    2012-11-01

    Through consultation of the historical literatures on Mr. CHEN Ying-long, investigating his teaching experiences in Xiamen Hospital of TCM and Xiamen University, the characteristics of his educational idea on acupuncture-moxibustion, are found as follows: great significance is found in the dissemination of Chengjiang acupuncture school in Minnan area of China and abroad through the combination of the succession of education from a masters to disciples and the classroom teaching; importance is attached to medical ethics, and priority is put on building up ethics and teaching by precept and example. In order to inherit the Chengjiang acupuncture school, Mr. CHEN focuses on fostering a proper studying method, emphasizes on the basic skills of acupuncture, reinforces clinical practice and techniques, edits books, and imparts knowledge and solves doubts.

  19. A Class of Integer Order and Fractional Order Hyperchaotic Systems via the Chen System

    NASA Astrophysics Data System (ADS)

    Xu, Fei

    2016-06-01

    In this article, we investigate the generation of a class of hyperchaotic systems via the Chen chaotic system using both integer order and fractional order differential equation systems. Based on the Chen chaotic system, we designed a system with four nonlinear ordinary differential equations. For different parameter sets, the trajectory of the system may diverge or display a hyperchaotic attractor with double wings. By linearizing the ordinary differential equation system with divergent trajectory and designing proper switching controls, we obtain a chaotic attractor. Similar phenomenon has also been observed in linearizing the hyperchaotic system. The corresponding fractional order systems are also considered. Our investigation indicates that, switching control can be applied to either linearized chaotic or nonchaotic differential equation systems to create chaotic attractor.

  20. [Professor Chen Quan-xin's experiences on treatment of facial paralysis].

    PubMed

    Wu, Hao

    2011-05-01

    The clinical experiences of Professor Chen Quan-xin on treatment of facial paralysis are introduced. Based on the theory of Chinese medicine and instructed by differentiation of syndromes, Professor Chen attached great importance on analysis of etiology and pathology in modern medicine, and emphasized on treatment of facial paralysis according to different classifications and stages in combination of differentiation of syndromes and differentiation of diseases. His selection of point is refined and accurate. Conduct of qi through needling manipulations and reinforcing and reducing methods in various degrees are promoted by him as well. And it is held that obvious enhancement of the therapeutic effect can be achieved since other treatments are combined according to different types and stages of the disease.

  1. A new paradigm for petascale Monte Carlo simulation: Replica exchange Wang Landau sampling

    SciTech Connect

    Li, Ying Wai; Vogel, Thomas; Wuest, Thomas; Landau, David P

    2014-01-01

    We introduce a generic, parallel Wang Landau method that is naturally suited to implementation on massively parallel, petaflop supercomputers. The approach introduces a replica-exchange framework in which densities of states for overlapping sub-windows in energy space are determined iteratively by traditional Wang Landau sampling. The advantages and general applicability of the method are demonstrated for several distinct systems that possess discrete or continuous degrees of freedom, including those with complex free energy landscapes and topological constraints.

  2. A new paradigm for petascale Monte Carlo simulation: Replica exchange Wang-Landau sampling

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Vogel, Thomas; Wüst, Thomas; Landau, David P.

    2014-05-01

    We introduce a generic, parallel Wang-Landau method that is naturally suited to implementation on massively parallel, petaflop supercomputers. The approach introduces a replica-exchange framework in which densities of states for overlapping sub-windows in energy space are determined iteratively by traditional Wang-Landau sampling. The advantages and general applicability of the method are demonstrated for several distinct systems that possess discrete or continuous degrees of freedom, including those with complex free energy landscapes and topological constraints.

  3. Bioactive sesquiterpenes isolated from the essential oil of Dalbergia odorifera T. Chen.

    PubMed

    Tao, Yi; Wang, Yi

    2010-07-01

    Investigation of the essential oil from the heartwood of Dalbergia odorifera T. Chen afforded the sesquiterpenes 1 and 2, that both showed anti-platelet activity. Their backbones were totally the same only with subtle difference in the chiral centre. Additionally, antithrombotic and anti-platelet activities of these two compounds were measured. The results showed that the antithrombotic activity of these two compounds was poor, while their anti-platelet activity was strong at middle and high concentrations.

  4. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN P-97-553...

  5. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

  6. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

  7. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN P-97-553...

  8. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN P-97-553...

  9. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

  10. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

  11. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

  12. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN P-97-553...

  13. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN P-97-553...

  14. Mapping Boron Dioxide (BO2) Light Emission During Ballistic Initiation of Boron

    DTIC Science & Technology

    2016-03-03

    ARL-TN-0738 ● FEB 2016 US Army Research Laboratory Mapping Boron Dioxide (BO2) Light Emission During Ballistic Initiation of...ARL-TN-0738 ● FEB 2016 US Army Research Laboratory Mapping Boron Dioxide (BO2) Light Emission During Ballistic Initiation of Boron...Technical Note 3. DATES COVERED (From - To) February 2013–February 2015 4. TITLE AND SUBTITLE Mapping Boron Dioxide (BO2) Light Emission During

  15. The role of herpesviruses (BoHV-1 and BoHV-4) and pestiviruses (BVDV and BDV) in ruminant abortion cases in western Turkey.

    PubMed

    Tuncer-Göktuna, Pelin; Alpay, Gizem; Öner, Eda Baldan; Yeşilbağ, Kadir

    2016-06-01

    The economic impact of abortions in ruminant breeders is one of the biggest problems in livestock. Of the infectious agents, viruses, especially herpesviruses and pestiviruses, are the most important causative agents of abortion in ruminants. In the present study, the role of herpesviruses (bovine herpesvirus-1 (BoHV-1), bovine herpesvirus-4 (BoHV-4)) and pestiviruses (bovine viral diarrhea virus (BVDV), border disease virus (BDV)) was investigated in cases of ruminant abortion between 2007 and 2015 in western Turkey. Out of 81 aborted fetal samples (60 calves, 19 lambs, and 2 kids), 42 were positive, which included 31 calves, 9 lambs, and 2 goats; 39 aborted fetal samples were negative for the pestivirus antigen ELISA. BoHV-1 antigen ELISA was positive in 3 cases which included 2 calves and 1 lamb; the remainder 78 cases were negative. Pestivirus and BoHV-1 were positive in 51.85 and 3.70 %, respectively, of the samples. According to PCR analysis, BoHV-4 was not encountered in any of the tested samples. In one of the calf fetus samples, both BVDV and BoHV-1 were positive; in one of the lamb fetus samples, BoHV-1 was positive. There was a much higher level of pestivirus antigen than the other viral agents evaluated in the study (p < 0.0001). The results of this study indicate that pestiviruses are a common viral cause of ruminant abortions in the examined area.

  16. Astrogeodetic works of Stevan P. Bo\\vsković

    NASA Astrophysics Data System (ADS)

    Dačić, Miodrag; Cvetković, Zorica

    2002-04-01

    The singularly long military and scientific career of Stevan P. Bo\\vsković began in late XIX century in the Kingdom of Serbia, was continued in the Kingdom of Yugoslavia, to be closed in the Federative People's Republic of Yugoslavia. His fruitful activity was devoted to geodesy and cartography in the framework of which a large part concerns the astronomical determinations of time, latitude and of azimuth at points on the soils of Serbia and Yugoslavia, along with the longitude determination. A special importance attaches to his efforts at establishing a continuity of these works in the region of Balkan Peninsula and a link between our networks and those of Europe.

  17. BoA: a versatile software for bolometer data reduction

    NASA Astrophysics Data System (ADS)

    Schuller, Frédéric

    2012-09-01

    Together with the development of the Large APEX Bolometer Camera (LABOCA) for the Atacama Pathfinder Experiment (APEX), a new data reduction package has been written. This software naturally interfaces with the telescope control system, and provides all functionalities for the reduction, analysis and visualization of bolometer data. It is used at APEX for real time processing of observations performed with LABOCA and other bolometer arrays, providing feedback to the observer. Written in an easy-to-script language, BoA is also used offline to reduce APEX continuum data. In this paper, the general structure of this software is presented, and its online and offline capabilities are described.

  18. Time budgets of Snow Geese Chen caerulescens and Ross's Geese Chen rossii in mixed flocks: Implications of body size, ambient temperature and family associations

    USGS Publications Warehouse

    Jonsson, J.E.; Afton, A.D.

    2009-01-01

    Body size affects foraging and forage intake rates directly via energetic processes and indirectly through interactions with social status and social behaviour. Ambient temperature has a relatively greater effect on the energetics of smaller species, which also generally are more vulnerable to predator attacks than are larger species. We examined variability in an index of intake rates and an index of alertness in Lesser Snow Geese Chen caerulescens caerulescens and Ross's Geese Chen rossii wintering in southwest Louisiana. Specifically we examined variation in these response variables that could be attributed to species, age, family size and ambient temperature. We hypothesized that the smaller Ross's Geese would spend relatively more time feeding, exhibit relatively higher peck rates, spend more time alert or raise their heads up from feeding more frequently, and would respond to declining temperatures by increasing their proportion of time spent feeding. As predicted, we found that Ross's Geese spent more time feeding than did Snow Geese and had slightly higher peck rates than Snow Geese in one of two winters. Ross's Geese spent more time alert than did Snow Geese in one winter, but alert rates differed by family size, independent of species, in contrast to our prediction. In one winter, time spent foraging and walking was inversely related to average daily temperature, but both varied independently of species. Effects of age and family size on time budgets were generally independent of species and in accordance with previous studies. We conclude that body size is a key variable influencing time spent feeding in Ross's Geese, which may require a high time spent feeding at the expense of other activities. ?? 2008 The Authors.

  19. The synthesis and crystal structures of the related series of aluminoborates: Co 2.1Al 0.9BO 5, Ni 2AlBO 5, and Cu 2AlBO 5

    NASA Astrophysics Data System (ADS)

    Hriljac, J. A.; Brown, R. D.; Cheetham, A. K.; Satek, L. C.

    1990-02-01

    We report on the growth of single crystals of Ni 2AlBO 5, Cu 2AlBO 5, and the mixed-valent Co 2.1Al 0.9BO 5 from borax fluxes. All of these materials have been studied by single-crystal X-ray diffraction. The nickel and cobalt compounds are isostructural with the natural mineral ludwigite, while the copper compound is a monoclinically distorted variant of this structure. All three compounds show nonrandom disorder of the transition metal and aluminium atoms over four crystallographically distinct metal sites. We discuss the structural effects of this disorder and attempt to rationalize the observed occupancies on the basis of covalent and ionic forces. Ni 2AlBO 5: orthorhombic, a = 12.013(1)Å, b = 9.111(1)Å, c = 2.942(1)Å, space group Pbam, Z = 4, R = 4.07%. Co 2.1Al 0.9BO 5: orthorhombic, a = 12.010(2)Å, b = 9.197(2)Å, c = 2.993(1)Å, space group Pbam, Z = 4, R = 4.44%. Cu 2AlBO 5: monoclinic, a = 9.365(1)Å, b = 11.778(2)Å, c = 3.072(2)Å, β = 97.71(2)°, space group P2 1a, Z = 4, R = 4.59% .

  20. High-pressure x-ray diffraction study of YBO{sub 3}/Eu{sup 3+}, GdBO{sub 3}, and EuBO{sub 3}: Pressure-induced amorphization in GdBO{sub 3}

    SciTech Connect

    Wang, Pei; Xu, Chao; Ren, Xiangting; Lei, Li; Wang, Shanmin; Peng, Fang; Yan, Xiaozhi; Liu, Dongqiong; Wang, Qiming; He, Duanwei; Xiong, Lun; Liu, Jing

    2014-01-28

    Angle-dispersive synchrotron X-ray diffraction measurements were performed on vaterite-type YBO{sub 3}/Eu{sup 3+}, GdBO{sub 3}, and EuBO{sub 3}, respectively, up to 41 GPa at room temperature using a diamond-anvil cell. Pressure-induced amorphization was observed in hexagonal GdBO{sub 3} with a significant compression along the c-axis. Compared to the ions of the distorted GdBO{sub 3} phase, its anions may lose their long-range order prior to the cations at high pressures. Based on the experimental pressure-volume data, the obtained bulk moduli of YBO{sub 3}/Eu{sup 3+} and GdBO{sub 3} are 329 and 321 GPa, respectively, which are more than 90% larger than that of EuBO{sub 3} (167 GPa) and are presumably attributed to Gd{sup 3+} and Y{sup 3+} with a high density of d valence electrons.

  1. Identifying potential BO2 oxide polymorphs for epitaxial growth candidates.

    PubMed

    Mehta, Prateek; Salvador, Paul A; Kitchin, John R

    2014-03-12

    Transition metal dioxides (BO2) exhibit a number of polymorphic structures with distinct properties, but the isolation of different polymorphs for a given composition is carried out using trial and error experimentation. We present computational studies of the relative stabilities and equations of state for six polymorphs (anatase, brookite, rutile, columbite, pyrite, and fluorite) of five different BO2 dioxides (B = Ti, V, Ru, Ir, and Sn). These properties were computed in a consistent fashion using several exchange correlation functionals within the density functional theory formalism, and the effects of the different functionals are discussed relative to their impact on predictive synthesis. We compare the computational results to prior observations of high-pressure synthesis and epitaxial film growth and then use this discussion to predict new accessible polymorphs in the context of epitaxial stabilization using isostructural substrates. For example, the relative stabilities of the columbite polymorph for VO2 and RuO2 are similar to those of TiO2 and SnO2, the latter two of which have been previously stabilized as epitaxial films.

  2. Nanosecond electron tunneling between the hemes in cytochrome bo3

    PubMed Central

    Jasaitis, Audrius; Johansson, Mikael P.; Wikström, Mårten; Vos, Marten H.; Verkhovsky, Michael I.

    2007-01-01

    Biological electron transfer (eT) between redox-active cofactors is thought to occur by quantum-mechanical tunneling. However, in many cases the observed rate is limited by other reactions coupled to eT, such as proton transfer, conformational changes, or catalytic chemistry at an active site. A prominent example of this phenomenon is the eT between the heme groups of mitochondrial cytochrome c oxidase, which has been reported to take place in several different time domains. The question of whether pure eT tunneling in the nanosecond regime between the heme groups can be observed has been the subject of some experimental controversy. Here, we report direct observations of eT between the heme groups of the quinol oxidase cytochrome bo3 from Escherichia coli, where the reaction is initiated by photolysis of carbon monoxide from heme o3. eT from CO-dissociated ferrous heme o3 to the low-spin ferric heme b takes place at a rate of (1.2 ns)−1 at 20°C as determined by optical spectroscopy. These results establish heme–heme electron tunneling in the bo3 enzyme, a bacterial relative to the mitochondrial cytochrome c oxidase. The properties of eT between the closely lying heme groups in the heme–copper oxidases are discussed in terms of the reorganization energy for the process, and two methods for assessing the rate of electron tunneling are presented. PMID:18087041

  3. Boronyl ligand as a member of the isoelectronic series BO(-) → CO → NO(+): viable cobalt carbonyl boronyl derivatives?

    PubMed

    Gong, Xiaoli; Li, Qian-Shu; Xie, Yaoming; King, R Bruce; Schaefer, Henry F

    2010-12-06

    Recently the first boronyl (oxoboryl) complex [(c-C(6)H(11))(3)P](2)Pt(BO)Br was synthesized. The boronyl ligand in this complex is a member of the isoelectronic series BO(-) → CO → NO(+). The cobalt carbonyl boronyls Co(BO)(CO)(4) and Co(2)(BO)(2)(CO)(7), with cobalt in the formal d(8) +1 oxidation state, are thus isoelectronic with the familiar homoleptic iron carbonyls Fe(CO)(5) and Fe(2)(CO)(9). Density functional theory predicts Co(BO)(CO)(4) to have a trigonal bipyramidal structure with the BO group in an axial position. The tricarbonyl Co(BO)(CO)(3) is predicted to have a distorted square planar structure, similar to those of other 16-electron complexes of d(8) transition metals. Higher energy Co(BO)(CO)(n) (n = 3, 2) structures may be derived by removal of one (for n = 3) or two (for n = 2) CO groups from a trigonal bipyramidal Co(BO)(CO)(4) structure. Structures with a CO group bridging 17-electron Co(CO)(4) and Co(BO)(2)(CO)(3) units and no Co-Co bond are found for Co(2)(BO)(2)(CO)(8). However, Co(2)(BO)(2)(CO)(8) is not viable because of the predicted exothermic loss of CO to give Co(2)(BO)(2)(CO)(7). The lowest lying Co(2)(BO)(2)(CO)(7) structure is a triply bridged (2BO + CO) structure closely related to the experimental Fe(2)(CO)(9) structure. However, other relatively low energy Co(2)(BO)(2)(CO)(7) structures are found, either with a single CO bridge, similar to the experimental Os(2)(CO)(8)(μ-CO) structure; or with 17-electron Co(CO)(4) and Co(BO)(2)(CO)(3) units joined by a single Co-Co bond with or without semibridging carbonyl groups. Both triplet and singlet Co(2)(BO)(2)(CO)(6) structures are found. The lowest lying triplet Co(2)(BO)(2)(CO)(6) structures have a Co(CO)(3)(BO)(2) unit coordinated to a Co(CO)(3) unit through the oxygen atoms of the boronyl groups with a non-bonding ∼4.3 Å Co···Co distance. The lowest lying singlet Co(2)(BO)(2)(CO)(6) structures have either two three-electron donor bridging η(2)-μ-BO groups and no Co

  4. EPR of Dy3+ ions in YAl3(BO3)4 and EuAl3(BO3)4 aluminoborates

    NASA Astrophysics Data System (ADS)

    Prokhorov, A. D.; Prokhorov, A. A.; Zubov, E. E.; Chernysh, L. F.; Dyakonov, V.; Szymczak, H.

    2014-08-01

    The EPR spectra of impurity Dy3+ ions in YAl3(BO3)4 and EuAl3(BO3)4 aluminoborates were investigated. The signals from the ground and excited doublets were observed and the g-factors and the hyperfine interaction constants were determined. From the temperature dependence of the signal intensity of the excited doublet, the energy distances between the ground and excited doublets were obtained as (3.26 ± 0.13) cm-1 and (2.54 ± 0.16) cm-1 for YAl3(BO3)4 and EuAl3(BO3)4, respectively. A broadening of the absorption line with increasing temperature is related with the strong spin-phonon interaction and is described by the Orbach-Aminov process via the excited doublet. It was found that the decrease in g-factor is caused by the spin-phonon interaction.

  5. Crystal structure of a new polar borate Na2Ce2[BO2(OH)][BO3]2 · H2O with isolated boron triangles

    NASA Astrophysics Data System (ADS)

    Topnikova, A. P.; Belokoneva, E. L.; Dimitrova, O. V.; Volkov, A. S.

    2016-11-01

    Crystals of a new polar borate Na2Ce2[BO2(OH)][BO3]2 · H2O were prepared by hydrothermal synthesis. The crystals are orthorhombic, a = 7.2295(7) Å, b = 11.2523(8) Å, c = 5.1285(6) Å, Z = 2, sp. gr. C2 mm ( Amm2), R = 0.0253. The formula of the compound was derived from the structure determination. The Ce and Na atoms are coordinated by nine and six O atoms, respectively. The Ce position is split, and a small amount of Ce is incorporated into the Na1 site with the isomorphous substitution for Na. The anionic moieties exist as isolated BO3 and BO2(OH) triangles. The planes of the BO2(OH) triangles with mm2 symmetry are parallel to the ab plane. The planes of the BO3 triangles with m symmetry are perpendicular to the ab plane and are rotated in a diagonal way. The splitting of the Ce positions and the polar arrangement of the BO2(OH) triangles, water molecules, and Na atoms are observed along the polar a axis. The new structure is most similar to the new borate NaCa4[BO3]3 (sp. gr. Ama2), in which triangles of one type are arranged in a polar fashion along the c axis. Weak nonlinear-optical properties of both polar borates are attributed to the quenching of the second-harmonic generation due to the mutually opposite orientation of two-thirds of B triangles in the unit cell.

  6. Source of the North Pacific ``boing'' sound attributed to minke whales

    NASA Astrophysics Data System (ADS)

    Rankin, Shannon; Barlow, Jay

    2005-11-01

    During a recent cetacean survey of the U.S. waters surrounding the Hawaiian Islands, the probable source of the mysterious ``boing'' sound of the North Pacific Ocean was identified as a minke whale, Balaenoptera acutorostrata. Examination of boing vocalizations from three research surveys confirms previous work that identified two distinct boing vocalization types in the North Pacific. The eastern boing (n=22) has a pulse repetition rate of 92 s-1 and a duration of 3.6 s and was found only east of 138°W. The central boing (n=106) has a pulse repetition rate of 115 s-1 and a duration of approximately 2.6 s and was found only west of 135°W. Central boing vocalizations produced by a single source (n=84) indicate that variation in repetition rate and duration of the calls of the individual were not significantly different than the variation among individuals of the same boing type. Despite a slight latitudinal overlap in the vocalizations, pulse repetition rates of the eastern and central boings were distinct.

  7. The Verification and Validation of the Ray-tracing of Bag of Triangles (BoTs)

    DTIC Science & Technology

    2015-02-01

    Force’s ray-tracer, FASTGEN, on BoTs. 15 . SUBJECT TERMS BRL–CAD, Ray-trace, BoTs 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...Bio Charith Ranawake is attending the University of Maryland College Park as a freshman in Computer Science. Before working on Ballistic Research

  8. 75 FR 8310 - Defense Acquisition University (DAU) Board of Visitors (BoV) Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... of the Secretary Defense Acquisition University (DAU) Board of Visitors (BoV) Meeting AGENCY: Defense Acquisition University, DoD. ACTION: Meeting notice. SUMMARY: The next meeting of the Defense Acquisition University (DAU) Board of Visitors (BoV) will be held at DAU Headquarters at Fort Belvoir, Virginia. The...

  9. Highly active Fe3BO6 as an anode material for sodium-ion batteries.

    PubMed

    Tian, Jianliya; Wang, Baofeng; Zhao, Fei; Ma, Xiao; Liu, Yong; Liu, Hua Kun; Huang, Zhenguo

    2017-04-12

    A highly efficient Fe3BO6 anode prepared via a solid-state synthesis method is studied for sodium-ion batteries. The Fe3BO6 anode shows high capacity and excellent rate capability. The ex situ X-ray diffraction results show that the Na(+) ion storage mechanism involves conversion based reactions between iron oxides and sodium.

  10. Chen's derivative rule revisited: Role of tip-orbital interference in STM

    NASA Astrophysics Data System (ADS)

    Mándi, Gábor; Palotás, Krisztián

    2015-04-01

    On the occasion of its 25th anniversary, we revise Chen's derivative rule for electron tunneling [C. J. Chen, Phys. Rev. B 42, 8841 (1990), 10.1103/PhysRevB.42.8841] for the purpose of computationally efficient simulations of scanning tunneling microscopy (STM) based on first-principles electronic structure data. The revised model allows the weighting of tunneling matrix elements of different tip-orbital characters by an arbitrary energy-independent choice or based on energy-dependent weighting coefficients obtained by an expansion of the tip single-electron wave functions/density of states projected onto the tip-apex atom. Tip-orbital interference in the STM junction is included in the model by construction and can be analyzed quantitatively. As a further advantage, arbitrary tip geometrical orientations are included in the revised model by rotating the coordinate system of the tip apex using Euler angles and redefining the weighting coefficients of the tunneling matrix elements. We demonstrate the reliability of the model by applying it to two functionalized surfaces of recent interest where quantum interference effects play an important role in the STM imaging process: N-doped graphene and a magnetic Mn2H complex on the Ag(111) surface. We find that the proposed tunneling model is 25 times faster than the Bardeen method concerning computational time, while maintaining good agreement. Our results show that the electronic structure of the tip has a considerable effect on STM images, and the Tersoff-Hamann model does not always provide sufficient results in view of quantum interference effects. For both studied surfaces, we highlight the importance of interference between s and pz tip orbitals that can cause a significant contrast change in the STM images. Our method, thus, provides a fast and reliable tool for calculating STM images based on Chen's derivative rule, taking into account the electronic structure and local geometry of the tip apex.

  11. Experimental and ab initio studies of Cd5(BO3)3Cl: the first cadmium borate chlorine NLO material with isolated BO3 groups.

    PubMed

    Song, Yunxia; Luo, Min; Liang, Fei; Lin, Chensheng; Ye, Ning; Yan, Guiyang; Lin, Zheshuai

    2017-09-18

    A nonlinear optical crystal cadmium borate chlorine (Cd5(BO3)3Cl) has been successfully grown through a spontaneous crystallization method. Cd5(BO3)3Cl crystallizes in the noncentrosymmetric space group Cm with isolated BO3 and distorted CdOnClm (n = 4, 5, 7; m = 0, 1, 2) polyhedra. Powder second harmonic generation (SHG) measurements on polycrystalline Cd5(BO3)3Cl indicated that the title compound is phase-matchable in the visible region and exhibits a large SHG response of about 5 × KH2PO4 (KDP). Further optical characterization suggested that the compound has a wide transparent region ranging from UV to near IR with a UV cutoff edge at about 295 nm. In addition, first-principles electronic structure calculations revealed that the macroscopic SHG coefficients of Cd5(BO3)3Cl originate from the cooperative effects of the BO3 groups with asymmetric π-delocalization, the d(10) cation Cd(2+) with the polar displacement and the Cl(-) anions.

  12. [Isolation, identification, phylogenetic analysis and related properties of a pathogen in Silurus meridionalis Chen].

    PubMed

    Cao, Hai-jun; Li, Yong-wen; Lei, Yu; Wu, Jiang; Xu, Heng

    2007-02-01

    In October 2005, a large number of adults of Silurus meridionalis Chen died in the mud fish farming of Sichuan province. Later, three predominate strains of bacteria were isolated from the body of moribund fish. By artificial infection tests, strain TWN3 was confirmed to be the pathogen of the disease. Based on the characteristics of morphology, physiology and biochemistry tests, TWN3 was initially identified as Proteus vulgaris, and its G + C content of DNA is 39.1% . After being amplified, the sequence of its 16S rDNA was analyzed in the database of NCBI and it showed that TWN3 had the highest similarity to P. vulgaris, with 99.52% identity. By constructing the molecular phylogenetic dendrogram with Minimum Evolution method in Mega3.1, it was revealed that TWN3 was in the same branch with P. vulgaris. Based on all the results above, TWN3 is identified as P. vulgaris. However, the result of one biochemistry test, growth in KCN, deviates from the description in Bergey's Manual of Systematic Bacteriology. With reference to the Manual above, Proteus vulgaris is divided into two groups, P. vulgaris BG2 and 3. According to the specific biochemical properties, TWN3 is classified as a member of P. vulgaris BG3. Relevant tests of biological properties were also conducted, which showed that this strain has no haemolysis and is sensitive to four kinds of antibiotic such as gentamicin. Moreover, it can strongly cause diseases to mice. The research on the growth property of strain TWN3 indicated that its growth temperature ranges from 10 degrees C to 43 degrees C , optimum 37 degrees C ; growth pH ranges from 4 to 11, optimum 6. Its optimum salinity varies under different temperatures, and it grows best under 1.5 % salinity while 37 degrees C. The aim of these researches is to provide an evidence for the prevention and cure of TWN3. According to the appearance of the diseased Silurus meridionalis Chen and results of artificial infection test on crucian carps, it is considered

  13. Secure communications based on the synchronization of the hyperchaotic Chen and the unified chaotic systems

    NASA Astrophysics Data System (ADS)

    Smaoui, N.; Karouma, A.; Zribi, M.

    2011-08-01

    This paper deals with the adaptive synchronization of two identical hyperchaotic master and slave systems. The master system and the slave system each consists of two subsystems: a hyperchaotic Chen subsystem and a unified chaotic subsystem. The asymptotic convergence of the errors between the states of the master system and the states of the slave system is proven using Lyapunov theory. Simulation results are presented to illustrate the ability of the control law to synchronize the master and slave systems. Moreover, the proposed control scheme is applied to encrypt and decrypt discrete signals such as digital images where computer simulation results are provided to show that the proposed control law works well.

  14. Theoretical and Practical Progress of New Heliostat by Chen et al.

    NASA Astrophysics Data System (ADS)

    Kribus, A.

    2006-01-01

    Recently, Chen and his team were active in the theoretical and practical study of a new heliostat for the use of solar energy. This work represents the first innovation in the area of heliostats after many years of little progress. The mathematical development of the tracking and concentration optics principles, and the practical implementation and demonstration of the technology, are both very interesting advances in this field. Many applications are possible for this technology such as generation of solar electricity and solar industrial process heat.

  15. Impact of Bovine Herpesvirus 4 (BoHV-4) on Reproduction.

    PubMed

    Chastant-Maillard, S

    2015-06-01

    Bovine herpesvirus 4 (BoHV-4) is increasingly considered as responsible for various reproductive troubles. This virus infects blood mononuclear cells and displays a specific tropism for vascular endothelia, mammary tissue, endometrium and foetal tissues. Viral multiplication can be reactivated by corticosteroids or stress, both factors present at calving. BoHV-4 has been isolated in a large variety of clinical cases, primarily metritis, vaginitis and mastitis, but also endometritis, abortion and orchitis. Its impact on reproductive performance has been suggested by several epidemiological studies: seroprevalence against BoHV-4 is higher in aborted females and in repeat breeders. Nevertheless, its intrinsic pathogenic power seems low, symptoms developing only when BoHV-4 cooperates with bacteria: within the uterus or mammary gland. BoHV-4 is rather currently considered as a cofactor for the development of an inflammatory reaction initiated by bacteria.

  16. Luminescent Characteristics of LiSrBO3:Eu3+ Phosphor for White Light Emitting Diode

    NASA Astrophysics Data System (ADS)

    Li, Pan-Lai; Wang, Zhi-Jun; Yang, Zhi-Ping; Guo, Qing-Lin

    2009-04-01

    LiSrBO3:Eu3+ phosphor is synthesized by a high solid-state reaction method, and its luminescent characteristics are investigated. The emission and excitation spectra of LiSrBO3:Eu3+ phosphors exhibit that the phosphors can be effectively excited by near ultraviolet (401 nm) and blue (471 nm) light, and emit 615 nm red light. The effect of Eu3+ concentration on the emission spectrum of LiSrBO3:Eu3+ phosphor is studied; the results show that the emission intensity increases with increasing Eu3+ concentration, and then decreases because of concentration quenching. It reaches the maximum at 3 mol%, and the concentration self-quenching mechanism is the dipoledipole interaction according to the Dexter theory. Under the conditions of charge compensation Li+, Na+ or K+ incorporated in LiSrBO3, the luminescent intensities of LiSrBO3:Eu3+ phosphor are enhanced.

  17. Chen Jingrun, China's famous mathematician: devastated by brain injuries on the doorstep to solving a fundamental mathematical puzzle.

    PubMed

    Lei, Ting; Belykh, Evgenii; Dru, Alexander B; Yagmurlu, Kaan; Elhadi, Ali M; Nakaji, Peter; Preul, Mark C

    2016-07-01

    Chen Jingrun (1933-1996), perhaps the most prodigious mathematician of his time, focused on the field of analytical number theory. His work on Waring's problem, Legendre's conjecture, and Goldbach's conjecture led to progress in analytical number theory in the form of "Chen's Theorem," which he published in 1966 and 1973. His early life was ravaged by the Second Sino-Japanese War and the Chinese Cultural Revolution. On the verge of solving Goldbach's conjecture in 1984, Chen was struck by a bicyclist while also bicycling and suffered severe brain trauma. During his hospitalization, he was also found to have Parkinson's disease. Chen suffered another serious brain concussion after a fall only a few months after recovering from the bicycle crash. With significant deficits, he remained hospitalized for several years without making progress while receiving modern Western medical therapies. In 1988 traditional Chinese medicine experts were called in to assist with his treatment. After a year of acupuncture and oxygen therapy, Chen could control his basic bowel and bladder functions, he could walk slowly, and his swallowing and speech improved. When Chen was unable to produce complex work or finish his final work on Goldbach's conjecture, his mathematical pursuits were taken up vigorously by his dedicated students. He was able to publish Youth Math, a mathematics book that became an inspiration in Chinese education. Although he died in 1996 at the age of 63 after surviving brutal political repression, being deprived of neurological function at the very peak of his genius, and having to be supported by his wife, Chen ironically became a symbol of dedication, perseverance, and motivation to his students and associates, to Chinese youth, to a nation, and to mathematicians and scientists worldwide.

  18. Synthesis and photoluminescence studies on YAl3(BO3)4:Tb3+ phosphor

    NASA Astrophysics Data System (ADS)

    Satheesh Kumar, Ranganathan; Ponnusamy, Velladurai; Jose, Mundiyanikal Thomas; Sivakumar, Vairan

    2014-12-01

    Terbium (Tb3+) doped yttrium aluminium borate phosphors (YAl3(BO3)4) with different compositions such as YAl3(BO3)4:Tb3+, Y1-xAl3(BO3)4:Tbx3+ and YAl(3-x)(BO3)4:Tbx3+ (x = 1-8 mol.%) were synthesized using modified solid state reaction technique. The synthesized phosphor was studied using powder X-ray diffraction analysis (XRD), photoluminescence spectroscopy (PL), high resolution-scanning electron microscope (HR-SEM). Lattice parameters are calculated for the Tb3+ doped and substituted YAB phosphors using XRD analysis. The phosphor exhibits green emission at 572 nm with 375 nm of excitation. It is found that the Tb3+ ions substitution in the sites Y3+ and Al3+ ions in Y1-xAl3(BO3)4:Tbx3+ and YAl(3-x)(BO3)4:Tbx3+ leads to overlapping of energy levels which affects the PL intensity of the phosphor significantly. Thus, phosphor synthesized with the composition YAl3(BO3)4:Tb3+, acquires higher photoluminescence (PL) intensity when compared to Y1-xAl3(BO3)4:Tbx3+ and YAl(3-x)(BO3)4:Tbx3+ phosphors. Temperature dependent PL property (thermal quenching studies) of YAl3(BO3)4:Tb3+ was also performed up to 250 °C. Further, it is found that the PL intensity of the studied phosphor is comparable with commercial green phosphor. HR-SEM analysis demonstrates that the phosphors are grown as nanorods with an average diameter of 50-80 nm and length 250-500 nm.

  19. Performance of replica-exchange Wang-Landau sampling for the study of spin systems

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Eisenbach, Markus; Vogel, Thomas; Wüst, Thomas; Landau, David P.

    2014-03-01

    The recently proposed replica-exchange Wang-Landau sampling (REWL) is a novel, massively parallel Monte Carlo method which allows for the parallelization of Wang-Landau sampling based on a replica-exchange framework. The robustness of the scheme is demonstrated by its broad applicability on a variety of spin systems: from the simplest models with discrete or continuous energy domains, to complex systems captured by large-scale first principles density functional theory calculations. The accuracy of REWL is studied by comparing the thermodynamic properties with exact solutions and results obtained by the original, serial Wang-Landau sampling. The principles for the speed-up, the strong and weak scaling behavior of REWL are also investigated when different parameter settings are employed. We will show, with the aid of selected spin systems, that the method accelerates the simulations significantly with a possible improved accuracy. Phys. Rev. Lett. 110, 210603 (2013)

  20. Characterization and classification of Bo4 as a cluster G mycobacteriophage that can infect and lyse M. tuberculosis.

    PubMed

    Gan, Yiling; Wu, Tingting; Liu, Ping; Guo, Shuliang

    2014-03-01

    Mycobacteriophage therapy is a potential alternative treatment for Mycobacterium tuberculosis infection. Here, we further characterized a mycobacteriophage, Bo4, and evaluated its ability to infect and kill M. tuberculosis. We first found that Bo4 can infect M. tuberculosis and Mycobacterium smegmatis. The observed clear plaques created by Bo4 infection indicated that Bo4 might be a lytic phage able to lyse mycobacterial strains, which was confirmed by phage antimicrobial activity. Bo4 formed clear zones in a medium with pH values of 7.4 or 5.0, suggesting the possibility that Bo4 could lyse mycobacteria, such as M. tuberculosis, in blood as well as in lysosomal macrophages. Further investigation into the Bo4 genome revealed that Bo4 had a dsDNA genome. Moreover, Bo4 contained ~39,318 bp comprised of 66.76 % G+C content. Complete genome sequencing showed high nucleotide identity with cluster G mycobacteriophages, thus classifying Bo4 as a member of the cluster G family. Additionally, annotation of the Bo4 genome indicated that it was a lytic bacteriophage and did not contain any harmful genes that increased mycobacterial virulence or decreased human immunity. Overall, the results of investigation indicate that the Bo4 possesses the potential to destroy M. tuberculosis, making it a potentially useful tool for diagnosing and treating tuberculosis.

  1. Absolute and geometric parameters of contact binary BO Arietis

    NASA Astrophysics Data System (ADS)

    Gürol, B.; Gürsoytrak, S. H.; Bradstreet, D. H.

    2015-08-01

    We present the results of our investigation on the geometrical and physical parameters of the W UMa type binary system BO Ari from analyzed CCD (BVRI) light curves and radial velocity data. The photometric data were obtained in 2009 and 2010 at Ankara University Observatory (AUO) and the spectroscopic observations were made in 2007 and 2010 at TUBITAK National Observatory (TUG). These light and radial velocity observations were analyzed simultaneously by using the Wilson-Devinney (2013 revision) code to obtain absolute and geometrical parameters. The system was determined to be an A-type W UMa system. Combining our photometric solution with the spectroscopic data we derived masses and radii of the eclipsing system to be M1 = 0.995M⊙,M2 = 0.189M⊙,R1 = 1.090R⊙ and R2 = 0.515R⊙ . Finally, we discuss the evolutionary status of the system.

  2. Characterization of 18 new BoLA-DRB3 alleles.

    PubMed

    Maillard, J C; Renard, C; Chardon, P; Chantal, I; Bensaid, A

    1999-06-01

    The second exon of the bovine MHC class II DRB3 gene was amplified by polymerase chain reaction (PCR) from DNA samples of 568 zebu Brahman cattle (Bos indicus) from Martinique (French West Indies). Cloning of these PCR products allowed the isolation of both alleles from each animal, which were characterized by the PCR-restriction fragment length polymorphism (RFLP) technique using the restriction enzymes RsaI, BstYI and HaeIII. Four new PCR-RFLP patterns were obtained by digestion with RsaI. These patterns were named 'v', 'w', 'x' and 'y' continuing the accepted nomenclature. Sequencing of each allele allowed the identification of 18 new BoLA-DRB3 exon 2 nucleotide sequences and their deduced amino acid sequences.

  3. Aperiodic compression and reconstruction of real-world material systems based on Wang tiles

    NASA Astrophysics Data System (ADS)

    Doškář, Martin; Novák, Jan; Zeman, Jan

    2014-12-01

    The paper presents a concept to compress and synthesize complex material morphologies that is based on Wang tilings. Specifically, a microstructure is stored in a set of Wang tiles and its reconstruction is performed by means of a stochastic tiling algorithm. A substantial part of the study is devoted to the setup of optimal parameters of the automatic tile design by means of parametric studies with statistical descriptors at heart. The performance of the method is demonstrated on four two-dimensional two-phase target systems, monodisperse media with hard and soft disks, sandstone, and high porosity metallic foam.

  4. Taylor E. Wang observes growth of crystals in VCGS aboard orbiter

    NASA Image and Video Library

    1985-05-03

    51B-14-038 (29 April-6 May 1985) --- Payload specialist Taylor G. Wang manipulates a 1.5 centimeter diameter sphere in the Drop Dynamics Module (DDM) in the science module aboard the earth-orbiting Space Shuttle Challenger. The photo was taken with a 35mm camera. Dr. Wang is principal investigator for the first-time-to-fly experiment, developed by his team at NASA's Jet Propulsion Laboratory (JPL) in Pasadena, California. This photo was one of the first released by NASA upon return to earth of the Spacelab 3 crewmembers.

  5. Replica-exchange Wang Landau sampling: pushing the limits of Monte Carlo simulations in materials sciences

    SciTech Connect

    Perera, Meewanage Dilina N; Li, Ying Wai; Eisenbach, Markus; Vogel, Thomas; Landau, David P

    2015-01-01

    We describe the study of thermodynamics of materials using replica-exchange Wang Landau (REWL) sampling, a generic framework for massively parallel implementations of the Wang Landau Monte Carlo method. To evaluate the performance and scalability of the method, we investigate the magnetic phase transition in body-centered cubic (bcc) iron using the classical Heisenberg model parameterized with first principles calculations. We demonstrate that our framework leads to a significant speedup without compromising the accuracy and precision and facilitates the study of much larger systems than is possible with its serial counterpart.

  6. Aperiodic compression and reconstruction of real-world material systems based on Wang tiles.

    PubMed

    Doškář, Martin; Novák, Jan; Zeman, Jan

    2014-12-01

    The paper presents a concept to compress and synthesize complex material morphologies that is based on Wang tilings. Specifically, a microstructure is stored in a set of Wang tiles and its reconstruction is performed by means of a stochastic tiling algorithm. A substantial part of the study is devoted to the setup of optimal parameters of the automatic tile design by means of parametric studies with statistical descriptors at heart. The performance of the method is demonstrated on four two-dimensional two-phase target systems, monodisperse media with hard and soft disks, sandstone, and high porosity metallic foam.

  7. Luminescence and Site Occupancy of Eu2+ in Ba2 Ca(BO3)2

    NASA Astrophysics Data System (ADS)

    Li, Pan-Lai; Wang, Zhi-Jun; Yang, Zhi-Ping; Guo, Qing-Lin

    2011-01-01

    A green phosphor Ba2Ca(BO3)2:Eu2+ was synthesized by a high temperature solid-state reaction method under a reductive atmosphere. The luminescence and site occupancy of Eu2+ in Ba2Ca(BO3)2 are investigated. Ba2Ca(BO3)2:Eu2+ shows one green band (537 nm) under 400 nm near ultraviolet excitation which is suitable for UV LED. Ca2+ and Ba2+ ions in Ba2Ca(BO3)2 are replaced by Eu2+ ions, the Ba2Ca(BO3)2:Eu2+ shows a dissymmetrical emission band. The influence of Eu2+ doping concentrations on the emission intensity of Ba2Ca(BO3)2:Eu2+ is studied. It is found that the emission intensity is influenced by the Eu2+ concentration and reaches the maximum value at 2% Eu2+. According to the Dexter theory, the concentration quenching mechanisms of Eu2+ in Ba2Ca(BO3)2 are the d-dinteraction.

  8. Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina.

    PubMed

    Baltian, L R; Ripoli, M V; Sanfilippo, S; Takeshima, S N; Aida, Y; Giovambattista, G

    2012-07-01

    Different studies have proved that the resistance/susceptibility to mastitis is genetically determined. The major histocompatibility complex in cows is known as bovine lymphocyte antigen (BoLA). Genes from the BoLA have been associated with the occurrence of infectious diseases such as mastitis and leukosis, especially the BoLA-DRB gene. The object of the present study was to detect associations between BoLA-DRB3 alleles and somatic cell count (SCC), as an indicator of resistance/susceptibility to mastitis in Holstein cattle (N = 123) from La Pampa, Argentina. Fisher's exact test and Woolf-Haldane odds ratio were applied to study the association between SCC and BoLA-DRB3 allele frequencies. Significant association was noted between BoLA-DRB3.2*23 and *27 alleles (p < 0.05) and protective or susceptibility effects, respectively. In addition, alleles BoLA-DRB3.2*20 and *25 exhibit suggestive association with high SCC (p < 0.1). These results were partially in agreement with data reported from Japanese Holstein cattle, but differed from those published by other authors. A possible explanation for the contrasting results could be that the mastitis is a multifactor disease caused by different pathogens. Moreover, most of the studies were carried out using PCR-RFLP method, which has less resolution than PCR-SBT because PCR-RFLP defined alleles included more than one sequenced alleles.

  9. Boronyl Mimics Gold: a Photoelectron Spectroscopy Study

    NASA Astrophysics Data System (ADS)

    Jian, Tian; Lopez, Gary; Wang, Lai-Sheng

    2015-06-01

    Previous studies have found that gold atom and boronyl bear similarities in bonding in many gas phase clusters. B10(BO), B12(BO), B3(BO)n (n=1, 2) were found to possess similar bonding and structures to B10Au, B12Au, B3Aun (n=1, 2), respectively. During the recent photoelectron spectroscopy experiments, the spectra of BiBO- and BiAu- clusters are found to exhibit similar patterns, hinting that they possess similar geometric structures. While BiAu- is a linear molecule, BiBO- is also linear. The similarity in bonding between BiBO- and BiAu- is owing to the fact that Au and BO are monovalent σ ligands. The electron affinities are measured to be 1.79±0.04eV for BiBO- and 1.36±0.02eV for BiAu-. The current results provide new examples for the BO/Au isolobal analogy and enrich the chemistry of boronyl and gold. H.-J. Zhai, C.-Q. Miao, S.-D. Li, L.-S. Wang, J. Phys. Chem. A 2010, 114, 12155-1216 Q. Chen, H. Bai, H.-J. Zhai, S.-D. Li, L.-S. Wang, J. Chem. Phys. 2013, 139, 044308 H. Bai, H.-J. Zhai, S.-D. Li, L.-S. Wang, Phys. Chem. Chem. Phys., 2013, 15, 9646-9653 H.-J. Zhai, Q. Chen, H. Bai, S.-D. Li, L.-S. Wang, Acc. Chem. Res. 2014, 47, 2435-2445

  10. The synthesis and crystal structures of the related series of aluminoborates: Co sub 2. 1 Al sub 0. 9 BO sub 55 , Ni sub 2 AlBO sub 5 , and Cu sub 2 AlBO sub 5

    SciTech Connect

    Hriljac, J.A.; Brown, R.D.; Cheetham, A.K. ); Satek, L.C. )

    1990-02-01

    We report on the growth of single crystals of Ni{sub 2}AlBO{sub 5}, Cu{sub 2}AlBO{sub 5}, and the mixed-valent Co{sub 2.1}Al{sub 0.9}BO{sub 5} from borax fluxes. All of these materials have been studied by single-crystal X-ray diffraction. The nickel and cobalt compounds are isostructural with the natural mineral ludwigite, while the copper compound is a monoclinically distorted variant of this structure. All three compounds show nonrandom disorder of the transition metal and aluminium atoms over four crystallographically distinct metal sites. We discuss the structural effects of this disorder and attempt to rationalize the observed occupancies on the basis of covalent and ionic forces. Ni{sub 2}AlBO{sub 5}: orthorhombic, a = 12.O13(1) {angstrom}, b = 9.111(1) {angstrom}, c = 2.942(1){angstrom}, space group Pbam, Z = 4, R = 4.07%. Co{sub 2.1}Al{sub 0.9}BO{sub 5}: orthorhombic, a = 12.010(2) {angstrom}, b = 9.197(2) {angstrom}, c = 2.993(1) {angstrom}, space group Pbam, Z = 4, R = 4.44%. Cu{sub 2}AlBO{sub 5}; monoclinic, a = 9.365(1) {angstrom}, b = 11.778(2) {angstrom}, c = 3.072(2) {angstrom}, {beta} = 97.71(2){degree}, space group P2{sub 1}/a, Z = 4, R = 4.59%.

  11. Genetic variation in BoLA microsatellite loci in Portuguese cattle breeds.

    PubMed

    Bastos-Silveira, C; Luís, C; Ginja, C; Gama, L T; Oom, M M

    2009-02-01

    Major histocompatibility complex (MHC) typing based on microsatellites can be a valuable approach to understanding the selective processes occurring at linked or physically close MHC genes and can provide important information on variability and relationships of populations. Using microsatellites within or in close proximity with bovine lymphocyte antigen (BoLA) genes, we investigated the polymorphisms in the bovine MHC, known as the BoLA, in eight Portuguese cattle breeds. Additional data from non-BoLA microsatellite loci were also used to compare the variability between these regions. Diversity was higher in BoLA than in non-BoLA microsatellites, as could be observed by the number of alleles, allelic richness and observed heterozygosity. Brava de Lide, a breed selected for aggressiveness and nobility, presented the lowest values of observed heterozygosity and allelic richness in both markers. Results from neutrality tests showed few statistically significant differences between the observed Hardy-Weinberg homozygosity (F) and the expected homozygosity (F(E)), indicating the apparent neutrality of the BoLA microsatellites within the analysed breeds. Nevertheless, we detected a trend of lower values of observed homozygosity compared with the expected one. We also detected some differences in the levels of allelic variability among the four BoLA microsatellites. Our data showed a higher number of alleles at the BoLA-DRB3 locus than at the BoLA-DRBP1 locus. These differences could be related to their physical position in the chromosome and may reflect functional requirements for diversity.

  12. Search for compounds of the NaBaR(BO{sub 3}){sub 2} family (R = La, Nd, Gd, and Yb) and the new NaBaYb(BO{sub 3}){sub 2} orthoborate

    SciTech Connect

    Svetlyakova, T. N. Kokh, A. E.; Kononova, N. G.; Fedorov, P. P.; Rashchenko, S. V.; Maillard, A.

    2013-01-15

    A search for compounds of the NaBaR(BO{sub 3}){sub 2} composition (where R = La{sup 3+}, Nd{sup 3+}, Gd{sup 3+}, or Yb{sup 3+}) is performed by solid state synthesis and spontaneous crystallization. A new compound, NaBaYb(BO{sub 3}){sub 2}, is found in this series. It crystallizes in space group R3{sup -} and belongs to the family of sublayer complex orthoborates with isolated BO{sub 3} groups NaBaR(BO{sub 3}){sub 2} (R = Y, Sc, and Yb). Theoretical X-ray powder diffraction patterns of NaBaY(BO{sub 3}){sub 2}, NaBaSc(BO{sub 3}){sub 2}, and NaBaYb(BO{sub 3}){sub 2} are calculated based on single-crystal data.

  13. Neodymium(III) molybdenum(VI) borate, NdBO(2)MoO(4).

    PubMed

    Held, Peter; van der Wolf, Benjamin; Bohatý, Ladislav; Becker, Petra

    2011-06-01

    Single crystals of NdBO(2)MoO(4) were obtained from a molybdenum oxide-boron oxide flux under an air atmosphere. The structure features double chains of edge- and face-sharing distorted [NdO(10)] bicapped square-anti-prisms, which are linked by rows of isolated [MoO(4)] tetra-hedra and by zigzag chains of corner-sharing [BO(3)] groups, all of them running along the b axis. The chains of [NdO(10)], chains of [BO(3)] and rows of [MoO(4)] groups are arranged in layers parallel to the bc plane.

  14. Untangling the Energetics and Dynamics of Boron Monoxide Radical Reactions (11BO; X2Sigma+)

    DTIC Science & Technology

    2015-04-15

    Crossed Beam Reaction of Boron Monoxide with Benzene (P6) Organyl oxoboranes (RBO) are valuable reagents in organic synthesis due to their role in...technique, phenyl oxoborane (C6H5BO) is formed through the reaction of boronyl radicals (BO) with benzene (C6H6). The reaction is indirect...Phenyloxo-borane (C6H5BO) via the Reaction of Boron Monoxide with Benzene . JOC 78, 11896- 11900 (2013). P7. R.I. Kaiser, S. Maity, B. Dangi, A,H.H

  15. V833 Cygni und BO Tauri - RRab-Sterne mit sehr kleinem Blazhko-Effekt

    NASA Astrophysics Data System (ADS)

    Maintz, Gisela

    2014-03-01

    CCD observations of V833 Cyg and BO Tau were obtained at my private observatory. 7 respectivly 8 maxima were observed. The period of V833 Cyg extends while that of BO Tau reduces. The elements of both stars were revised. V833 Cyg, Max = 2456500.4305 + 0.5381725 * E +-0.0000001 d BO Tau, Max = 2456639.43900 + 0.4451475 * E +-0.0000001 d. A very weak Blazhko effect is found with both stars. Gisela Maintz is a member of the BAV.

  16. Commentary: A Closer Look at Task Analysis--Reactions to Wang, Schnipke, and Witt

    ERIC Educational Resources Information Center

    LaDuca, Tony

    2006-01-01

    In the Spring 2005 issue, Wang, Schnipke, and Witt provided an informative description of the task inventory approach that centered on four functions of job analysis. The discussion included persuasive arguments for making systematic connections between tasks and KSAs. But several other facets of the discussion were much less persuasive. This…

  17. Learning from Wang Yang-Ming: Exploring Oriental Contributions to Understanding Action Research

    ERIC Educational Resources Information Center

    Tickle, Les

    2005-01-01

    This article reports recent foraging for ideas in action research among the lives and intellects of Chinese society. It began and is reported as a personal journey, initially following the trail of the activist scholar Wang Yang-Ming. The method is a roam through some of the resources that have so far been discovered. The style is…

  18. Dynamically optimized Wang-Landau sampling with adaptive trial moves and modification factors.

    PubMed

    Koh, Yang Wei; Lee, Hwee Kuan; Okabe, Yutaka

    2013-11-01

    The density of states of continuous models is known to span many orders of magnitudes at different energies due to the small volume of phase space near the ground state. Consequently, the traditional Wang-Landau sampling which uses the same trial move for all energies faces difficulties sampling the low-entropic states. We developed an adaptive variant of the Wang-Landau algorithm that very effectively samples the density of states of continuous models across the entire energy range. By extending the acceptance ratio method of Bouzida, Kumar, and Swendsen such that the step size of the trial move and acceptance rate are adapted in an energy-dependent fashion, the random walker efficiently adapts its sampling according to the local phase space structure. The Wang-Landau modification factor is also made energy dependent in accordance with the step size, enhancing the accumulation of the density of states. Numerical simulations show that our proposed method performs much better than the traditional Wang-Landau sampling.

  19. A Response to Ling-chi Wang, Elaine Kim, and Sucheng Chan.

    ERIC Educational Resources Information Center

    Takaki, Ronald

    1990-01-01

    Replies to every criticism in the foregoing essays of Ling-chi Wang, Elaine Kim, and Sucheng Chan. Endorses Chan's call for more in-depth research. Explains that the size of the book and the number of sources prevented closer annotation in the first edition. (DM)

  20. Learning from Wang Yang-Ming: Exploring Oriental Contributions to Understanding Action Research

    ERIC Educational Resources Information Center

    Tickle, Les

    2005-01-01

    This article reports recent foraging for ideas in action research among the lives and intellects of Chinese society. It began and is reported as a personal journey, initially following the trail of the activist scholar Wang Yang-Ming. The method is a roam through some of the resources that have so far been discovered. The style is…

  1. Solution of the Wang Chang-Uhlenbeck equation for molecular hydrogen

    NASA Astrophysics Data System (ADS)

    Anikin, Yu. A.

    2017-06-01

    Molecular hydrogen is modeled by numerically solving the Wang Chang-Uhlenbeck equation. The differential scattering cross sections of molecules are calculated using the quantum mechanical scattering theory of rigid rotors. The collision integral is computed by applying a fully conservative projection method. Numerical results for relaxation, heat conduction, and a one-dimensional shock wave are presented.

  2. Synthesis and crystal structure of new layered BaNaSc(BO 3) 2 and BaNaY(BO 3) 2 orthoborates

    NASA Astrophysics Data System (ADS)

    Seryotkin, Yurii V.; Bakakin, Vladimir V.; Kokh, Aleksandr E.; Kononova, Nadezhda G.; Svetlyakova, Tatyana N.; Kokh, Konstantin A.; Drebushchak, Tatyana N.

    2010-05-01

    Crystals of two new layered BaNaSc(BO 3) 2 ( I) and BaNaY(BO 3) 2 ( II) orthoborates are grown from the melt-solution by the spontaneous crystallization onto the platinum loop. Single crystal X-ray analysis showed that the compounds are isostructural with the space group R3¯, a=5.23944(12) and 5.3338(2) Å, and c=34.5919(11) and 35.8303(19) Å for I and II, respectively, Z=6. The distinctive feature of the structure is the close-packed composite anion-cation (Ba,Na)(BO 3) layers. The layers are combined into the base building packages of two types: { M3+[Ba 2+(BO 3) 3-] 2} + and { M3+[Na +(BO 3) 3-] 2} -, where M is Sc or Y. Neutral-charge two-package (four-layer) blocks are stacked by the rhombohedral principle into twelve layers of the cubic packing.

  3. Pi and sigma double conjugations in boronyl polyboroene nanoribbons: Bn(BO)2- and Bn(BO)2 (n = 5-12)

    NASA Astrophysics Data System (ADS)

    Zhai, Hua-Jin; Chen, Qiang; Bai, Hui; Lu, Hai-Gang; Li, Wei-Li; Li, Si-Dian; Wang, Lai-Sheng

    2013-11-01

    A series of boron dioxide clusters, BxO2- (x = 7-14), have been produced and investigated using photoelectron spectroscopy and quantum chemical calculations. The dioxide clusters are shown to possess elongated ladder-like structures with two terminal boronyl (BO) groups, forming an extensive series of boron nanoribbons, Bn(BO)2- (n = 5-12). The electron affinities of Bn(BO)2 exhibit a 4n periodicity, indicating that the rhombic B4 unit is the fundamental building block in the nanoribbons. Both π and σ conjugations are found to be important in the unique bonding patterns of the boron nanoribbons. The π conjugation in these clusters is analogous to the polyenes (aka polyboroenes), while the σ conjugation plays an equally important role in rendering the stability of the nanoribbons. The concept of σ conjugation established here has no analogues in hydrocarbons. Calculations suggest the viability of even larger boronyl polyboroenes, B16(BO)2 and B20(BO)2, extending the boron nanoribbons to ˜1.5 nm in length or possibly even longer. The nanoribbons form a new class of nanowires and may serve as precursors for a variety of boron nanostructures.

  4. Forcing term in single-phase and Shan-Chen-type multiphase lattice Boltzmann models.

    PubMed

    Huang, Haibo; Krafczyk, Manfred; Lu, Xiyun

    2011-10-01

    Numerous schemes have been proposed to incorporate a bulk forcing term into the lattice Boltzmann equation. In this paper we present a simple and straightforward comparative analysis of five popular schemes [Shan and Chen, Phys. Rev. E 47, 1815 (1993); Phys Rev Lett. 81, 1618 (1998); He et al., Phys. Rev. E 57, R13 (1998); Guo et al., Phys. Rev. E 65, 046308 (2002); Kupershtokh et al., Comput. Math. Appl. 58, 965 (2009)] in which their differences and similarities are identified. From the analysis we classify the schemes into two groups; the behaviors of the schemes in each group are proven to be identical up to second order. Numerical test simulating the two-dimensional unsteady Taylor-Green vortex flow problem demonstrate that all five schemes are of comparable accuracy for single-phase flow. However, for two-phase flow the situation is different, which is demonstrated by incorporating these schemes into different Shan-Chen-type multiphase models. The forcing scheme in the original Shan-Chen (SC) multiphase model turns out to be inaccurate in terms of the resulting surface tension for different density ratios and relaxation times. In the numerical tests, a typical equation of state and interparticle interactions including next-nearest neighbors were incorporated into the SC model. Our results confirm that the surface-tension values obtained from the original SC lattice Boltzmann method (LBM) simulation depend on the value of the relaxation time τ. For τ<0.7Δt, the surface tension agree well with the analytical solutions. However, when τ>0.7Δt, the surface tension turns out to be systematically larger than the analytical one, exceeding it by more than a factor of 2 for τ=2Δt. In contrast, with the application of the scheme proposed by He et al., the SC LBM produces very accurate surface tensions independent of the value of τ. We also found that the densities of the coexisting liquid and gas can be adjusted to match those at thermodynamic equilibrium if the

  5. Twisted gauge theories in three-dimensional Walker-Wang models

    NASA Astrophysics Data System (ADS)

    Wang, Zitao; Chen, Xie

    2017-03-01

    Three-dimensional gauge theories with a discrete gauge group can emerge from spin models as a gapped topological phase with fractional point excitations (gauge charge) and loop excitations (gauge flux). It is known that 3D gauge theories can be "twisted," in the sense that the gauge flux loops can have nontrivial braiding statistics among themselves and such twisted gauge theories are realized in models discovered by Dijkgraaf and Witten. A different framework to systematically construct three-dimensional topological phases was proposed by Walker and Wang and a series of examples have been studied. Can the Walker-Wang construction be used to realize the topological order in twisted gauge theories? This is not immediately clear because the Walker-Wang construction is based on a loop condensation picture while the Dijkgraaf-Witten theory is based on a membrane condensation picture. In this paper, we show that the answer to this question is Yes, by presenting an explicit construction of the Walker-Wang models which realize both the twisted and untwisted gauge theories with gauge group Z2×Z2 . We identify the topological order of the models by performing modular transformations on the ground-state wave functions and show that the modular matrices exactly match those for the Z2×Z2 gauge theories. By relating the Walker-Wang construction to the Dijkgraaf-Witten construction, our result opens up a way to study twisted gauge theories with fermonic charges, and correspondingly strongly interacting fermionic symmetry protected topological phases and their surface states, through exactly solvable models.

  6. The model test of restoration project of the gravel beach of Chen Village fishing port

    NASA Astrophysics Data System (ADS)

    Wang, D. X.; Gui, J. S.; Sun, J. W.

    2016-08-01

    Gravel beach is a case in coastal landform by wave action. It is more and more crucial for the environment of coastal engineering in recent years. However, it is poorly studied for it in China. And this paper which is based on the model test of Restoration Project of the Gravel Beach of Chen Village Fishing Port, uses two dimensional normal physical models, aiming at exploring the movement of gravel beach under wave action and verifying the stability of the gravel beach section. The test depends on different water levels (designed high water level, designed low water level, and extreme high water level) and return periods (2, 5, 10, 25, 50 years once). Finally, two distinct experimental sections are got under the changed conditions and the movement law of gravels is obtained.

  7. A VAS-numerical model impact study using the Gal-Chen variational approach

    NASA Technical Reports Server (NTRS)

    Aune, Robert M.; Tuccillo, James J.; Uccellini, Louis W.; Petersen, Ralph A.

    1987-01-01

    A numerical study based on the use of a variational assimilation technique of Gal-Chen (1983, 1986) was conducted to assess the impact of incorporating temperature data from the VISSR Atmospheric Sounder (VAS) into a regional-scale numerical model. A comparison with the results of a control forecast using only conventional data indicated that the assimilation technique successfully combines actual VAS temperature observations with the dynamically balanced model fields without destabilizing the model during the assimilation cycle. Moreover, increasing the temporal frequency of VAS temperature insertions during the assimilation cycle was shown to enhance the impact on the model forecast through successively longer forecast periods. The incorporation of a nudging technique, whereby the model temperature field is constrained toward the VAS 'updated' values during the assimilation cycle, further enhances the impact of the VAS temperature data.

  8. Extended Chen: a new class of chaotic fractional-order systems

    NASA Astrophysics Data System (ADS)

    Nasrollahi, A.; Bigdeli, N.

    2014-11-01

    A new class of chaotic fractional-order systems is introduced and its necessary conditions for chaotic behaviour of this class have been provided. These chaotic systems are constructed based on the extension of fractional-order chaotic Chen system by addition of a general function term, satisfying some necessary conditions. This property makes the chaotic behaviour of the extended system, to large extent, independent of the selected function and so a vast range of chaotic systems can be synthesized. The main application of the proposed chaotic systems may be in secure communication systems. To make the subject clearer and in order for validation of the proposed model, five examples are provided and their results are simulated. The results confirm the theoretic analyses very well.

  9. [BO's abdominal acupuncture for obese type-2 diabetes mellitus].

    PubMed

    Yang, Yuan; Liu, Yunxia

    2015-04-01

    To observe the clinical efficacy of BO's abdominal acupuncture for obese type-2 diabetes mellitus (T2DM). Sixty patients of obese T2DM were randomly divided into an acupuncture group and a medication group, 30 cases in each one. Patients in the medication group were treated with basic treatment combined with oral administration of regular antidiabetics, three weeks as one session. Patients in the acupuncture group, based on the medication group, were treated with abdominal acupuncture at Yinqiguiyuan [Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6), Guanguan (CV 4)], Fusiguan [Huaroumen (ST 24), Wailing (TE 5)], Tianshu (ST 25), Daheng (SP 15), Qixue (KI 13), etc.; the treatment was given three times per week, 3 weeks as one session. The systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight, waist circumference (WC), hip circumference, body mass index (BI) were observed before and after treatment in the two groups, and fasting plasma glucose (FPG), fasting insulin (FINS), 2-hours postprandial blood glucose by oral glucose tolerance test (OGTT) and insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), HOMA-IR of insulin resistance index were calculated and adverge events were recorded. Compared before the treatment, SBP, WC, body weight, BMI, FPG, OG-TT2hBG, FINS, GTT2h insulin, HOMA-IR, TC and LDL-C in the acupuncture group were all significantly reduced (all P <0. 05), while FPG, OGTT2H insulin and TG were increased in the medication group (all P<0. 05)'. The differences of reducing SBP, WC, FPG, OGTT2H insulin, HOMA-IR, TC, TG and LDL-C were statistically significant between the two groups (all P<0. 05). The total effective rate was 93. 3% (28/30) in the acupuncture group, which was significantly superior to 23. 3% (7/30) in the medication group (P<0. 01). BO's abdominal acupuncture has obvious clinical efficacy for obese type-2 diabetes mellitus

  10. Extended stellar substructure surrounding the Boötes I dwarf spheroidal galaxy

    NASA Astrophysics Data System (ADS)

    Roderick, T. A.; Mackey, A. D.; Jerjen, H.; Da Costa, G. S.

    2016-10-01

    We present deep stellar photometry of the Boötes I dwarf spheroidal galaxy in g- and i-band filters, taken with the Dark Energy Camera at Cerro Tololo in Chile. Our analysis reveals a large, extended region of stellar substructure surrounding the dwarf, as well as a distinct overdensity encroaching on its tidal radius. A radial profile of the Boötes I stellar distribution shows a break radius indicating the presence of extra-tidal stars. These observations strongly suggest that Boötes I is experiencing tidal disruption, although not as extreme as that exhibited by the Hercules dwarf spheroidal. Combined with revised velocity dispersion measurements from the literature, we see evidence suggesting the need to review previous theoretical models of the Boötes I dwarf spheroidal galaxy.

  11. FLOYDS Classification of ASASSN-17bo/AT 2017wb as a Young Type Ia Supernova

    NASA Astrophysics Data System (ADS)

    Hosseinzadeh, G.; Arcavi, I.; Howell, D. A.; McCully, C.; Valenti, S.

    2017-01-01

    We obtained a spectrum of ASASSN-17bo/AT 2017wb (ATel #10022) on 2017 January 30.4 UT with the robotic FLOYDS instrument mounted on the Las Cumbres Observatory 2-meter telescope on Haleakala, Hawai'i.

  12. Phase transitions in FeBO3 under pressure: DFT+DMFT study

    NASA Astrophysics Data System (ADS)

    Dyachenko, A. A.; Shorikov, A. O.; Anisimov, V. I.

    2017-09-01

    We present a theoretical study of spectral, magnetic, and structural properties of the iron borate FeBO3. Within the DFT+DMFT method combining density functional theory with dynamical mean-field theory FeBO3 was investigated under pressures up to 70 GPa at 300 K. We found that FeBO3 is an insulator with a gap of 2.0 eV with antiferromagnetic ordering at ambient pressure in agreement with experiments. In our calculations we showed that Fe ions in FeBO3 undergo a high-spin to low-spin transition under pressure with change from antiferromagnetic to paramagnetic state, and demonstrate that the spin and magnetic transitions occur simultaneously with an isostructural transition at 50.4 GPa with the volume collapse of 13%.

  13. A vibrational spectroscopic study of the borate mineral takedaite Ca3(BO3)2

    NASA Astrophysics Data System (ADS)

    Frost, Ray L.; López, Andrés; Xi, Yunfei; Graça, Leonardo M.; Scholz, Ricardo

    2014-11-01

    We have studied the mineral takedaite Ca3(BO3)2, a borate mineral of calcium using SEM with EDX and vibrational spectroscopy. Chemical analysis shows a homogeneous phase, composed of Ca. Boron was not detected. A very intense Raman band at 1087 cm-1 is assigned to the BO stretching vibration of BO3 units. Additional Raman bands may be due to isotopic splitting. In the infrared spectrum, bands at 1218 cm-1 and at 1163, 1262 and 1295 cm-1 are assigned to the trigonal borate stretching modes. Raman bands at 712 and 715 cm-1 are assigned to the in-plane bending modes of the BO3 units. Vibrational spectroscopy enables aspects of the molecular structure of takedaite to be assessed.

  14. 48. Quincy, MA, BO37, Launch Area, Underground Missile Storage Structure, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Quincy, MA, BO-37, Launch Area, Underground Missile Storage Structure, interior detail of water and hydraulic pumps VIEW WEST - NIKE Missile Battery PR-79, Launch Area, East Windsor Road south of State Route 101, Foster, Providence County, RI

  15. Surviving track through Bridge No. 1601, Third B&O Crossing, looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Surviving track through Bridge No. 1601, Third B&O Crossing, looking west. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  16. A vibrational spectroscopic study of the borate mineral takedaite Ca3(BO3)2.

    PubMed

    Frost, Ray L; López, Andrés; Xi, Yunfei; Graça, Leonardo M; Scholz, Ricardo

    2014-11-11

    We have studied the mineral takedaite Ca3(BO3)2, a borate mineral of calcium using SEM with EDX and vibrational spectroscopy. Chemical analysis shows a homogeneous phase, composed of Ca. Boron was not detected. A very intense Raman band at 1087 cm(-1) is assigned to the BO stretching vibration of BO3 units. Additional Raman bands may be due to isotopic splitting. In the infrared spectrum, bands at 1218 cm(-1) and at 1163, 1262 and 1295 cm(-1) are assigned to the trigonal borate stretching modes. Raman bands at 712 and 715 cm(-1) are assigned to the in-plane bending modes of the BO3 units. Vibrational spectroscopy enables aspects of the molecular structure of takedaite to be assessed. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, Rhode Island & Brentwood Avenues on the south, 18th Street & South Dakota Avenue on the east, and Michigan Avenue on the North, Washington, District of Columbia, DC

  18. BoLA class I allele diversity and polymorphism in a herd of cattle.

    PubMed

    Babiuk, Shawn; Horseman, Benjamin; Zhang, Chenhong; Bickis, Mik; Kusalik, Anthony; Schook, Lawrence B; Abrahamsen, Mitchell S; Pontarollo, Reno

    2007-02-01

    Major histocompatibility complex class I genes are among the most polymorphic genes characterized. The high level of polymorphism is essential for generating host immune responses. In humans, three distinct genomic loci encode human leukocyte antigen (HLA) class I genes, allowing individuals to express up to six different HLA class I molecules. In cattle, the number of distinct genomic loci are currently at least six, and the number of different bovine leukocyte antigens (BoLA) class I molecules that are expressed in individual animals are variable. The extent of allele variation within the cattle population is unknown. In this study, the number and variety of BoLA class I sequences expressed by 36 individuals were determined from full-length BoLA class I cDNA clones. Twenty distinct BoLA class I alleles were identified, with only four being previously reported. The number of expressed BoLA class I alleles in individual animals ranged between one and four, with none of the animals having an identical complement of BoLA class I molecules. Variation existed in the number of BoLA class I alleles expressed as well as the composition of expressed alleles, however, several BoLA class I alleles were found in multiple individual animals. Polymorphic amino acid sites were analyzed for positive and negative selection using the ADAPTSITE program. In the antigen recognition sites (ARS), there were eight positions that were predicted to be under positive selection and three positions that were predicted to be under negative selection from 62 positions. In contrast, for non-antigen recognition sites (non-ARS), there were three positions that were predicted to be under positive selection and 20 that were predicted to be under negative selection from 278, indicating that positive selection of amino acids occurs at a greater frequency within the antigen recognition sites.

  19. In situ high pressure investigations on metastable BiBO{sub 3}

    SciTech Connect

    Khanna, Atul; Mishra, A. K.; Sharma, S. M.

    2016-05-23

    Synchrotron based angle dispersive x-ray diffraction (ADXRD) studies were performed on metastable crystalline bismuth orthoborate (BiBO{sub 3}) up to 14.5 GPa during compression and decompression cycle. These studies revealed that the BiBO{sub 3} is unstable and it converts to Bi{sub 4}B{sub 2}O{sub 9} phase at high pressure. Moreover the transformation is found to be irreversible.

  20. Effect of BoLA-DRB3 exon2 polymorphisms on lameness of Chinese Holstein cows.

    PubMed

    Sun, Liping; Song, Yapan; Riaz, Hasan; Yang, Liguo

    2013-02-01

    The involvement of bovine lymphocyte antigen (BoLA) in immune system and its role in susceptibility/resistance to infectious diseases has been extensively studied. However, few studies have been conducted to investigate the association between BoLA and gait scores. Our objective was to investigate whether polymorphisms in BoLA gene are associated with susceptibility of lameness in 435 Chinese Holstein cows. Genotyping of the BoLA-DRB3.2 gene was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with three restriction endonucleases (BstUI, BstYI and HaeIII). The relationship between the polymorphisms in BoLA-DRB3.2 gene and gait scores was analyzed by least-squares linear model. The gait score was non-significant among all five BstUI-RFLP and BstYI-RFLP genotypes. However, analysis of seven HaeIII-RFLP genotypes revealed a significantly higher gait score for AB genotype than others. In conclusion, BoLA-DRB3.2 may be a candidate gene for lameness susceptibility in Chinese Holstein cows.

  1. Spectroscopic study of the magnetic ordering in SmFe 3(BO 3) 4

    NASA Astrophysics Data System (ADS)

    Chukalina, E. P.; Popova, M. N.; Bezmaternykh, L. N.; Gudim, I. A.

    2010-04-01

    SmFe 3(BO 3) 4 belongs to the family of rare-earth RFe 3(BO 3) 4 multiferroics. We present the first measurements of the optical spectra of SmFe 3(BO 3) 4 (on single crystals) and report the data on the crystal-field levels and their symmetries for the ground multiplet 6H 5/2 [0 ( Γ), 135 ( Γ), and 220 ( Γ) cm -1] and on the ground-state exchange splitting (13.2 cm -1 at 1.7 K), important to interpret the magnetic, magnetoelectric, and thermodynamic properties of this compound. The observed exchange splitting of the Sm 3+ Kramers doublets manifests the magnetic ordering in SmFe 3(BO 3) 4 at 32±1 K. From a comparison of the temperature-dependent spectra of the Sm 3+ ion in SmFe 3(BO 3) 4 and in Nd-Gd mixed iron borate where the magnetic spin reorientation has been found earlier, we suggest the easy-plane arrangement of the Fe spins in SmFe 3(BO 3) 4. The samarium iron borate preserves the R32 ( D37) crystal structure at all the investigated temperatures (down to 1.7 K).

  2. Preparation and scintillation properties of translucent LiCaBO3:Ce polycrystalline plates

    NASA Astrophysics Data System (ADS)

    Toyoda, Saki; Higuchi, Mikio; Tsubota, Youichi; Kaneko, Junichi H.; Tadanaga, Kiyoharu

    2017-08-01

    Translucent LiCaBO3:Ce thin plates were prepared by liquid phase sintering using LiBO2 as a sintering aid, and their fluorescent and scintillation properties were investigated to examine the possibility to use as neutron scintillator. Since the initial part of the directionally solidified specimen contained a second phase of Ca3B2O6, LiCaBO3 may melt incongruently, and simple melt growth of LiCaBO3:Ce is consequently difficult. Translucent thin plates 300 μm in thickness were successfully fabricated from LiCaBO3:Ce sintered compacts. Although strong fluorescence with the peak wavelength of 390 nm was observed in photoluminescence measurement, scintillation light yield and detection efficiency by α-particle irradiation were rather poor. The diffuse reflectance spectrum of LiCaBO3:Ce revealed existence of an absorption band other than Ce3+ bands in the ultraviolet region. The band may corresponds to defect levels, which interrupt the energy transfer from the conduction band of the host to the 5d level of Ce3+ resulting in the degradation of the scintillation performance.

  3. BoS: a large and diverse family of short interspersed elements (SINEs) in Brassica oleracea.

    PubMed

    Zhang, Xiaoyu; Wessler, Susan R

    2005-05-01

    Short interspersed elements (SINEs) are nonautonomous non-LTR retrotransposons that populate eukaryotic genomes. Numerous SINE families have been identified in animals, whereas only a few have been described in plants. Here we describe a new family of SINEs, named BoS, that is widespread in Brassicaceae and present at approximately 2000 copies in Brassica oleracea. In addition to sharing a modular structure and target site preference with previously described SINEs, BoS elements have several unusual features. First, the head regions of BoS RNAs can adopt a distinct hairpin-like secondary structure. Second, with 15 distinct subfamilies, BoS represents one of the most diverse SINE families described to date. Third, several of the subfamilies have a mosaic structure that has arisen through the exchange of sequences between existing subfamilies, possibly during retrotransposition. Analysis of BoS subfamilies indicate that they were active during various time periods through the evolution of Brassicaceae and that active elements may still reside in some Brassica species. As such, BoS elements may be a valuable tool as phylogenetic makers for resolving outstanding issues in the evolution of species in the Brassicaceae family.

  4. Towards Transformation of Knowledge and Subjectivity in Curriculum Inquiry: Insights from Chen Kuan-Hsing's "Asia as Method"

    ERIC Educational Resources Information Center

    Lin, Angel M. Y.

    2012-01-01

    Chen's book, "Asia as Method" (Duke University Press, 2010), and his theorization on topics of de-imperialization, de-colonization, de-cold war, as well as on foregrounding epistemologies and frames of reference situated in the diverse contexts in Asia have contributed to empowering scholars and researchers situated not only in Taiwan,…

  5. A comparative assessment of the Chen et al. and Suchey-Brooks pubic aging methods on a North American sample, .

    PubMed

    Fleischman, Julie M

    2013-03-01

    Accurately estimating the age-at-death of adult human skeletons is fundamental in forensic anthropology. This study evaluates the accuracy of two pubic bone age estimation methods-Chen et al. and Suchey-Brooks. Specimens were obtained from a known collection of modern pubic bones curated at the Maricopa County Forensic Science Center in Phoenix, Arizona. A sample of 296 left male pubic bones of European ancestry was statistically evaluated via bias, absolute mean error, and intra- and inter-observer error. Results indicate that the two methods are similar; the Suchey-Brooks method is the most accurate for aging young adults (error c. 7 years), while the Revised Chen et al. method is most accurate for aging middle-age adults (error c. 6 years). Thus, the Chen et al. method is an important contribution to forensic anthropology for aging older adult skeletal remains. There are, however, some limitations such as subjectivity and the intricate scoring system of Chen et al. method.

  6. Towards Transformation of Knowledge and Subjectivity in Curriculum Inquiry: Insights from Chen Kuan-Hsing's "Asia as Method"

    ERIC Educational Resources Information Center

    Lin, Angel M. Y.

    2012-01-01

    Chen's book, "Asia as Method" (Duke University Press, 2010), and his theorization on topics of de-imperialization, de-colonization, de-cold war, as well as on foregrounding epistemologies and frames of reference situated in the diverse contexts in Asia have contributed to empowering scholars and researchers situated not only in Taiwan,…

  7. Retraction Statement: 'MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer' by Li J, Wang J, Wang Y, Qiu H.

    PubMed

    2017-02-01

    The above article from APMIS, published online on 24 April 2015 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 123, pp. 562-570, has been retracted by agreement between the authors, the journal Editors in Chief, Professors Bodil Norrild, Ben Vainer and Elisabeth Ralfkiaer, and John Wiley & Sons Ltd. The article has been retracted due to errors in the reported results. In this study, the authors used HeLa and SiHa cell lines to investigate the biological roles of miR-218. However, subsequently it emerged that the two cell lines were contaminated in the laboratory by other unknown cell lines. When repeating the experiments, it was found that the functions of miR-218 were not as significant as had been previously reported, especially its effects on rapamycin sensitivity. Reference Li J, Li X, Wang J, Wang Y, Qiu H. MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer. APMIS 2015; 123:562-570. doi: 10.1111/apm.12387.

  8. Modern process study on Chen Co and Ranwu Lake of Tibetan Plateau

    NASA Astrophysics Data System (ADS)

    Ju, J.

    2013-12-01

    Lakes are important junctions of geospheres. There are many lakes distributed on the Tibetan Plateau (TP). Lake sediment is one of the important media for retrieving the past environmental changes. Because of the uniqueness of environment of the TP, sediment, water and ecological system in lakes has local characteristic inevitably. Modern process research on different lakes will benefit interpreting the proxies more accurately. The development of observation station makes the observation and sampling more convenient. Modern process of lakes can be fulfilled in two ways, spatial or seasonal variation study, with a same aim finding out the dominant factors controlling the variations. Chen Co is a closed lake locating at inland area of southern Tibet. Ranwu Lake is an open lake locating at outflow area of SE Tibet. In this study, I studied the spatial and (or) seasonal variation of lake water and sediment in the two distinct types of lakes to make clear the mechanism of modern process. Particular attention was given to the pattern and degree of influence of rivers supplied by glaciers on lakes. Preliminary conclusions are outlined as follow: (1) In the lakes with glacier melt supplying rivers, the patterns of supply of the rivers to the lake are different. In close lake Chen Co, the influence of glacier melt is mainly reflected in the south lake area. In the open lake Ranwu Lake, the influence is comprehensive and direct. This difference influencing patterns how the lake sediments reflected the glacier melt under the past environmental changes. (2) The supply of Kaluxiong Qu River, supplied mainly by glacier melt, to Chen co has North-South difference: more directly to south lake area, reflecting by lower value of conductivity and pH, finer grain size and west to east transporting trend, greater deposition rate, more allogenic fine sediments, not obvious biological and endogenic deposition there. This enlightens the site selection for lake cores and interpretation of

  9. Wang-Landau Reaction Ensemble Method: Simulation of Weak Polyelectrolytes and General Acid-Base Reactions.

    PubMed

    Landsgesell, Jonas; Holm, Christian; Smiatek, Jens

    2017-02-14

    We present a novel method for the study of weak polyelectrolytes and general acid-base reactions in molecular dynamics and Monte Carlo simulations. The approach combines the advantages of the reaction ensemble and the Wang-Landau sampling method. Deprotonation and protonation reactions are simulated explicitly with the help of the reaction ensemble method, while the accurate sampling of the corresponding phase space is achieved by the Wang-Landau approach. The combination of both techniques provides a sufficient statistical accuracy such that meaningful estimates for the density of states and the partition sum can be obtained. With regard to these estimates, several thermodynamic observables like the heat capacity or reaction free energies can be calculated. We demonstrate that the computation times for the calculation of titration curves with a high statistical accuracy can be significantly decreased when compared to the original reaction ensemble method. The applicability of our approach is validated by the study of weak polyelectrolytes and their thermodynamic properties.

  10. [Experience summary of professor WANG Fuchun's "Zhenjing Anshen" acupuncture method for insomnia].

    PubMed

    Li, Tie; Ha, Lijuan; Cao, Fang; Zhi, Mujun; Wang, Fuchun

    2015-11-01

    The experience of "Zhenjing Anshen" acupuncture method originally created by professor WANG Fuchun for treatment of insomnia was introduced in this paper. From aspects of insomnia pathogenesis, theoretical foundation, characteristics of acupoint selection, needing methods, needing time, etc., the experience of Professor WANG Fuchun for treatment of insomnia was explained. The "Zhenjing Anshen" acupuncture method proposed, for the first time, "new three layers" method of acupoint selection, including Sishencong (EX-HN 1), Shenmen (HT 7), Sanyinjiao (SP 6). This method presents the principles of acupoint selection along meridian, acupoint selection based on essence-qi-spirit, harmony of yin and yang. The acupuncture manipulation is emphasized, and treating time (the period of the day from 3 pm to 5 pm) is focused on; acupoint selection is simple but essential, and acupoint combination is scientific, which receives notable therapeutic effect in clinic.

  11. Four systems involved with congenital abnormalities: a new type of syndromic hearing loss - ADOC Wang's syndrome?

    PubMed

    Wang, Qiuju; Zhao, Fei-Fan; Shi, Yong-Bing

    2011-10-01

    Syndromic hearing impairment encompasses hundreds of phenotypes. We identified a young female patient affected by the unique combination of dysplasia of the auricular system, patent ductus arteriosus (PDA), choroideremia, and enamel hypoplasia. The patient was treated with PDA ligature and left exploratory tympanotomy. Impairment in all four systems suggests a correlation with the neural crest. It is presumed that all of the features result from the same origin, probably through autosomal recessive inheritance or a novel mutation during the embryonic period. When audio-dento-oculo-cardio systems are involved, we suggest that this new syndrome can be named 'ADOC Wang's syndrome', summarizing the disorders of the four systems and indicative of the founding person (Dr Wang, the first and corresponding author of the paper).

  12. Application of the Wang-Landau Monte-Carlo Formalism applied to Ferroelectrics materials

    NASA Astrophysics Data System (ADS)

    Bin Omran, Saad; Kornev, Igor; Bellaiche, Laurent

    The conventional description of phase transitions in ferroelectrics is based on canonical thermodynamic functions and always assumes the thermodynamic limit of an infinite system. However, ferroelectrics at nanoscale recently became of high interest due to their potential applications in minuaturized devices. It is this timely and more appropriate to use the microcanonical ensemble when mimicking ferroelectric systems. Interestingly, a Monte Carlo method based on the density of states (or microcanonical ensemble partition function) proposed by Wang and Landau has the potential to over-come these difficulties. Here, the Wang-Landau Monte Carlo algorithm is implemented within an effective Hamiltonian approach and used to conduct a detailed study of physical properties of BaTiO3 bulk. In this presentation, we will show how this approach allows a highly-accurate and straightforward calculation of various thermodynamic properties, including phase transition temperatures, as well as polarization, dielectric susceptibility, specific heat and electrocaloric coefficient at any temperature.

  13. Becoming an International Scientist in South Korea: Ho Wang Lee's Research Activity about Epidemic Hemorrhagic Fever.

    PubMed

    Shin, Miyoung

    2017-04-01

    In the 1960-70s, South Korea was still in the position of a science latecomer. Although the scientific research environment in South Korea at that time was insufficient, there was a scientist who achieved outcomes that could be recognized internationally while acting in South Korea. He was Ho Wang Lee(1928~ ) who found Hantann Virus that causes epidemic hemorrhagic fever for the first time in the world. It became a clue to identify causative viruses of hemorrhagic diseases that were scattered here and there throughout the world. In addition, these outcomes put Ho Wang Lee on the global center of research into epidemic hemorrhagic fever. This paper examines how a Korean scientist who was in the periphery of virology could go into the central area of virology. Also this article shows the process through which the virus found by Ho Wang Lee was registered with the international academia and he proceeded with follow-up research based on this progress to reach the level at which he generalized epidemic hemorrhagic fever related studies throughout the world. While he was conducting the studies, experimental methods that he had never experienced encountered him as new difficulties. He tried to solve the new difficulties faced in his changed status through devices of cooperation and connection. Ho Wang Lee's growth as a researcher can be seen as well as a view of a researcher that grew from a regional level to an international level and could advance from the area of non-mainstream into the mainstream. This analytic tool is meaningful in that it can be another method of examining the growth process of scientists in South Korea or developing countries.

  14. Exploring new frontiers in statistical physics with a new, parallel Wang-Landau framework

    SciTech Connect

    Vogel, Thomas; Li, Ying Wai; Wuest, Thomas; Landau, David P

    2014-01-01

    Combining traditional Wang Landau sampling for multiple replica systems with an exchange of densities of states between replicas we describe a general framework for simulations on massively parallel Petaflop supercomputers. The advantages and general applicability of the method for simulations of complex systems are demonstrated for the classical 2D Potts spin model featuring a strong first-order transition and the self-assembly of lipid bilayers in amphiphilic solutions in a continuous model.

  15. Wang-Landau sampling in face-centered-cubic hydrophobic-hydrophilic lattice model proteins.

    PubMed

    Liu, Jingfa; Song, Beibei; Yao, Yonglei; Xue, Yu; Liu, Wenjie; Liu, Zhaoxia

    2014-10-01

    Finding the global minimum-energy structure is one of the main problems of protein structure prediction. The face-centered-cubic (fcc) hydrophobic-hydrophilic (HP) lattice model can reach high approximation ratios of real protein structures, so the fcc lattice model is a good choice to predict the protein structures. The lacking of an effective global optimization method is the key obstacle in solving this problem. The Wang-Landau sampling method is especially useful for complex systems with a rough energy landscape and has been successfully applied to solving many optimization problems. We apply the improved Wang-Landau (IWL) sampling method, which incorporates the generation of an initial conformation based on the greedy strategy and the neighborhood strategy based on pull moves into the Wang-Landau sampling method to predict the protein structures on the fcc HP lattice model. Unlike conventional Monte Carlo simulations that generate a probability distribution at a given temperature, the Wang-Landau sampling method can estimate the density of states accurately via a random walk, which produces a flat histogram in energy space. We test 12 general benchmark instances on both two-dimensional and three-dimensional (3D) fcc HP lattice models. The lowest energies by the IWL sampling method are as good as or better than those of other methods in the literature for all instances. We then test five sets of larger-scale instances, denoted by the S, R, F90, F180, and CASP target instances on the 3D fcc HP lattice model. The numerical results show that our algorithm performs better than the other five methods in the literature on both the lowest energies and the average lowest energies in all runs. The IWL sampling method turns out to be a powerful tool to study the structure prediction of the fcc HP lattice model proteins.

  16. Exploring new frontiers in statistical physics with a new, parallel Wang-Landau framework

    NASA Astrophysics Data System (ADS)

    Vogel, Thomas; Li, Ying Wai; Wüst, Thomas; Landau, David P.

    2014-03-01

    Combining traditional Wang-Landau sampling for multiple replica systems with an exchange of densities of states between replicas, we describe a general framework for simulations on massively parallel Petaflop supercomputers. The advantages and general applicability of the method for simulations of complex systems are demonstrated for the classical 2D Potts spin model featuring a strong first-order transition and the self-assembly of lipid bilayers in amphiphilic solutions in a continuous model.

  17. Two alternate proofs of Wang's lune formula for sparse distributed memory and an integral approximation

    NASA Technical Reports Server (NTRS)

    Jaeckel, Louis A.

    1988-01-01

    In Kanerva's Sparse Distributed Memory, writing to and reading from the memory are done in relation to spheres in an n-dimensional binary vector space. Thus it is important to know how many points are in the intersection of two spheres in this space. Two proofs are given of Wang's formula for spheres of unequal radii, and an integral approximation for the intersection in this case.

  18. The impact of systematic landscape conservation planning on ecosystem: Chen Youlan river watershed

    NASA Astrophysics Data System (ADS)

    Chen, Chi-ju

    2017-04-01

    Heraclitus said that "no man ever steps in the same river twice." Everything continues to change. Land use change will keep redefine itself and subject the Earth and humankind to collateral changes. Humankind benefits from ecosystem in many ways. The ecosystem provides people with nutrients, enriches soil with sediment, and sustains all living organisms with water; these benefits are known as ecosystem services. In Taiwan, land use change has impacted ecosystem and biodiversity on various levels. Thus, we took six land use scenarios from 1999 to 2005 in Chen Youlan river watershed as our case study, intending to observe the course of ecosystem and biodiversity changes and the cause of it. Systematic Landscape conservation planning (SLCP) framework can be adopted when designing land use policy to safeguard human interests and ecosystem. This study use SLCP to develop ecosystem services and biodiversity protection strategies. Several strategies were designed by using 1999 to 2005 data as provision to protect the intactness of future ecosystem services and biodiversity. This research explores the potential and possible impacts of different land use protection strategies in the future. It is possible to identify the conservation priority of a certain region by using the Zonation meta-algorithm. This study selects the zonation critical protection area (Joint set of Yushan National Park) as strategy A, B and C. Strategy D takes Yushan National Park as a protected area; unstable hot spots in 1999/03 (Joint set of Yushan National Park) are selected as strategy E. Next, we used Kappa statistical method to find the minimal ecosystem services change and biodiversity hotspots change of the five aforementioned strategies and compared with those from 1999/03. By the Kappa statistical method, we further prioritized the important conservation areas by strategy A, B, C, E in the future. The results can not only serve as management reference for government agencies, but also develop

  19. Dynamical traps in Wang-Landau sampling of continuous systems: Mechanism and solution

    NASA Astrophysics Data System (ADS)

    Koh, Yang Wei; Sim, Adelene Y. L.; Lee, Hwee Kuan

    2015-08-01

    We study the mechanism behind dynamical trappings experienced during Wang-Landau sampling of continuous systems reported by several authors. Trapping is caused by the random walker coming close to a local energy extremum, although the mechanism is different from that of the critical slowing-down encountered in conventional molecular dynamics or Monte Carlo simulations. When trapped, the random walker misses the entire or even several stages of Wang-Landau modification factor reduction, leading to inadequate sampling of the configuration space and a rough density of states, even though the modification factor has been reduced to very small values. Trapping is dependent on specific systems, the choice of energy bins, and the Monte Carlo step size, making it highly unpredictable. A general, simple, and effective solution is proposed where the configurations of multiple parallel Wang-Landau trajectories are interswapped to prevent trapping. We also explain why swapping frees the random walker from such traps. The efficacy of the proposed algorithm is demonstrated.

  20. Exploring Replica-Exchange Wang-Landau sampling in higher-dimensional parameter space

    NASA Astrophysics Data System (ADS)

    Valentim, Alexandra; Rocha, Julio C. S.; Tsai, Shan-Ho; Li, Ying Wai; Eisenbach, Markus; Fiore, Carlos E.; Landau, David P.

    2015-09-01

    We considered a higher-dimensional extension for the replica-exchange Wang- Landau algorithm to perform a random walk in the energy and magnetization space of the two-dimensional Ising model. This hybrid scheme combines the advantages of Wang-Landau and Replica-Exchange algorithms, and the one-dimensional version of this approach has been shown to be very efficient and to scale well, up to several thousands of computing cores. This approach allows us to split the parameter space of the system to be simulated into several pieces and still perform a random walk over the entire parameter range, ensuring the ergodicity of the simulation. Previous work, in which a similar scheme of parallel simulation was implemented without using replica exchange and with a different way to combine the result from the pieces, led to discontinuities in the final density of states over the entire range of parameters. From our simulations, it appears that the replica-exchange Wang-Landau algorithm is able to overcome this difficulty, allowing exploration of higher parameter phase space by keeping track of the joint density of states.

  1. Highly parallel computational study of amphiphilic molecules using the Wang--Landau method

    NASA Astrophysics Data System (ADS)

    Vogel, Thomas; Landau, David

    2012-02-01

    The self-assembly process in amphiphilic solutions is a phenomenon of broad interest. Molecular dynamics simulations generally used to study micelle formation or lipid layer assembly in an explicit solvent are limited in time scale. Vast studies of structure formation processes via standard Markov-chain based Monte Carlo simulations are challenging, but the Wang--Landau method [1] provides a way to efficiently study such systems in a generalized thermodynamic ensemble. This makes it possible, for example, to get results over a broad temperature range from a single simulation. In an attempt to develop highly parallel applications using this method, we study the thermodynamic behavior of a generic coarse-grained model for amphiphilic molecules [2] as well as of a new coarse-grained lipid model specifically designed for dimyristoyl phosphatidylcholine (DMPC) [3]. Here, we focus on the design and the performance of our parallel Wang--Landau simulation on multi-CPU and GPU systems.[4pt] [1] F. Wang and D.P. Landau, Phys. Rev. Lett. 86, 2050 (2001)[0pt] [2] S. Fujiwara et al., J. Chem. Phys. 130, 144901 (2009)[0pt] [3] W. Shinoda et al., J. Phys. Chem. B 114, 6836 (2010)

  2. Dynamical traps in Wang-Landau sampling of continuous systems: Mechanism and solution.

    PubMed

    Koh, Yang Wei; Sim, Adelene Y L; Lee, Hwee Kuan

    2015-08-01

    We study the mechanism behind dynamical trappings experienced during Wang-Landau sampling of continuous systems reported by several authors. Trapping is caused by the random walker coming close to a local energy extremum, although the mechanism is different from that of the critical slowing-down encountered in conventional molecular dynamics or Monte Carlo simulations. When trapped, the random walker misses the entire or even several stages of Wang-Landau modification factor reduction, leading to inadequate sampling of the configuration space and a rough density of states, even though the modification factor has been reduced to very small values. Trapping is dependent on specific systems, the choice of energy bins, and the Monte Carlo step size, making it highly unpredictable. A general, simple, and effective solution is proposed where the configurations of multiple parallel Wang-Landau trajectories are interswapped to prevent trapping. We also explain why swapping frees the random walker from such traps. The efficacy of the proposed algorithm is demonstrated.

  3. Exploring Replica-Exchange Wang-Landau sampling in higher-dimensional parameter space

    SciTech Connect

    Valentim, Alexandra; Rocha, Julio C. S.; Tsai, Shan-Ho; Li, Ying Wai; Eisenbach, Markus; Fiore, Carlos E; Landau, David P

    2015-01-01

    We considered a higher-dimensional extension for the replica-exchange Wang-Landau algorithm to perform a random walk in the energy and magnetization space of the two-dimensional Ising model. This hybrid scheme combines the advantages of Wang-Landau and Replica-Exchange algorithms, and the one-dimensional version of this approach has been shown to be very efficient and to scale well, up to several thousands of computing cores. This approach allows us to split the parameter space of the system to be simulated into several pieces and still perform a random walk over the entire parameter range, ensuring the ergodicity of the simulation. Previous work, in which a similar scheme of parallel simulation was implemented without using replica exchange and with a different way to combine the result from the pieces, led to discontinuities in the final density of states over the entire range of parameters. From our simulations, it appears that the replica-exchange Wang-Landau algorithm is able to overcome this diculty, allowing exploration of higher parameter phase space by keeping track of the joint density of states.

  4. Identification of four novel alleles of the BoLA-DRB3 upstream regulatory region in Chinese yellow cattle.

    PubMed

    Wang, K; Sun, D-X; Li, K-Y; Wang, X-Q; Zhang, F

    2012-07-01

    The sequence of upstream regulatory region (URR) of BoLA-DRB3 gene was amplified with polymerase chain reaction followed by DNA sequencing from six animals of Chinese yellow cattle. A total of five alleles including four newly identified ones, named BoLA-DRB3*R-03-U2, BoLA-DRB3*R-06-U2, BoLA-DRB3*R-07-U and BoLA-DRB3*R-12-U for the BoLA-DRB3 URR were found. Result of sequence analysis showed that the regulatory elements W, X, Y, CCAAT and TATA-like boxes existed in such URRs and 16 polymorphic sites (11 transitions, 3 transversions, 1 deletion and 1 insertion) located in the spacers between the conserved consensus boxes and 1 insertion within X box, while no new polymorphic site within the consensus boxes.

  5. A new method for simultaneous detection and discrimination of Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) using real time PCR with high resolution melting (HRM) analysis.

    PubMed

    Marin, M S; Quintana, S; Leunda, M R; Recavarren, M; Pagnuco, I; Späth, E; Pérez, S; Odeón, A

    2016-01-01

    Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are antigenically and genetically similar. The aim of this study was to develop a simple and reliable one-step real time PCR assay with high resolution melting (HRM) analysis for the simultaneous detection and differentiation of BoHV-1 and BoHV-5. Optimization of assay conditions was performed with DNA from reference strains. Then, DNA from field isolates, clinical samples and tissue samples of experimentally infected animals were studied by real time PCR-HRM. An efficient amplification of real time PCR products was obtained, and a clear melting curve and appropriate melting peaks for both viruses were achieved in the HRM curve analysis for BoHV type identification. BoHV was identified in all of the isolates and clinical samples, and BoHV types were properly differentiated. Furthermore, viral DNA was detected in 12/18 and 7/18 samples from BoHV-1- and BoHV-5-infected calves, respectively. Real time PCR-HRM achieved a higher sensitivity compared with virus isolation or conventional PCR. In this study, HRM was used as a novel procedure. This method provides rapid, sensitive, specific and simultaneous detection of bovine alpha-herpesviruses DNA. Thus, this technique is an excellent tool for diagnosis, research and epidemiological studies of these viruses in cattle. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Thermoluminescence characteristics of Zn(BO2)2:Ce3+ under beta irradiation.

    PubMed

    Kucuk, Nil; Kucuk, Ilker; Yüksel, Mehmet; Topaksu, Mustafa

    2016-03-01

    In this study, the thermoluminescence (TL) characteristics of undoped and various Ce(3) (+)-doped Zn(BO2)2 powder samples excited by beta irradiation are reported for the first time. Zn(BO2)2:Ce(3+) powder samples were prepared by the nitric acid method (NAM) using the starting oxides [zinc oxide (ZnO), boric acid (H3BO3) and doped element oxide (CeO2)]. The formations of the obtained samples were confirmed by an X-ray diffraction study. Dose responses of Ce(3) (+)-doped Zn(BO2)2 samples were investigated after the beta irradiation in the dose range from 143 mGy to 60 Gy. All TL measurements were made on using an automated Risø TL/OSL DA-20 reader. TL emission was detected through a filter pack (Schott BG-39 and Corning 7-59) transmitting between 330 and 480 nm. TL glow curves were obtained using a constant heating rate of 5°C s(-1) from room temperature (RT) to 450°C in an N2 atmosphere. The dose response and minimum detectable dose (MDD) values of the samples were determined. The dose responses of all the samples tested exhibited a superlinear behaviour. MDD value of 4 % Ce(3) (+)-doped Zn(BO2)2 sample, which shows a high temperature peak at about 230°C, was determined as 96 mGy. MDD values for 1, 2, 3, 5 and 10 % Ce(3) (+)-doped Zn(BO2)2 samples were also determined as 682, 501, 635, 320 and 824 mGy, respectively. The trap parameters of undoped and 4 % Ce(3) (+)-doped Zn(BO2)2 samples were estimated by the computerised glow curve deconvolution method.

  7. Quasi-spherical LuBO{sub 3} nanoparticles: Synthesis, formation, and luminescence properties

    SciTech Connect

    Gao, Yu; Yang, Feng; Han, Wenchi; Fang, Qinghong; Xu, Zhenhe

    2014-03-01

    Graphical abstract: Quasi-spherical LuBO3 nanoparticles have been prepared via a facile hydrothermal route. The possible growth mechanism and the luminescent properties of the as-prepared microcrystals have been discussed. - Highlights: • LuBO{sub 3} nanoparticles were prepared by a facile hydrothermal route. • The Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong red and green emissions. • This method may be more widely applicable in the design of other rare-earth compounds. - Abstract: Quasi-spherical LuBO{sub 3} nanoparticles have been successfully synthesized by a designed hydrothermal conversion method. The Lu(OH)CO{sub 3} nanoparticles were first prepared by a simple homogeneous precipitation method. Subsequently, LuBO{sub 3} nanoparticles were synthesized at the expense of the Lu(OH)CO{sub 3} nanoparticles during a hydrothermal conversion process. The conversion process from the Lu(OH)CO{sub 3} precursor to LuBO{sub 3} nanoparticles was investigated by time-dependent experiments. Moreover, the as-obtained Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong characteristic red and green emissions under ultraviolet excitation and low-voltage electron beam excitation, respectively. This work sheds some light on the knowledge of conversion of different kind of lutetium compounds, and the luminescent properties have potential applications in fluorescent lamps and field emission displays. More importantly, this simple method is expected to allow the large-scale production of other complex rare-earth compounds with controllable morphologies and sizes, and exploration of the morphology and photoluminescence properties.

  8. Novel Sr3Bi2(BO3)4:Eu3+ red phosphor: Synthesis, crystal structure, luminescent and thermal properties

    NASA Astrophysics Data System (ADS)

    Shablinskii, A. P.; Bubnova, R. S.; Kolesnikov, I. E.; Krzhizhanovskaya, M. G.; Povolotskiy, A. V.; Ugolkov, V. L.; Filatov, S. K.

    2017-08-01

    Novel compound, Sr3Bi2(BO3)4, and Sr3Bi2(BO3)4:Eu3+ series were firstly synthesized by crystallization from a melt. The crystal structures of Sr3Bi2(BO3)4 and Sr3Bi1.66Eu0.34(BO3)4 borates were refined from single crystal X-ray diffraction data to R1 = 0.051 and 0.067, respectively. Sr3Bi2(BO3)4 borate crystallizes in the orthorhombic space group Pnma, a = 7.5107 (5), b = 16.2737 (11), c = 8.8163 (5) Å, V = 1077.59 (12) Å3, Z = 4. These compounds are isotypical to those of A3REE2(BO3)4 family, A = Ca, Sr, Ba. Crystal structure consists of isolated BO3 triangles and three independent M1O8, M2O8 and M3O8 polyhedra, which are connected by corners and edges forming the framework. The distribution of Sr and Bi atoms is partially disordered over M1-M3 positions. Thermal transformations of Sr3Bi2(BO3)4:Eu3+ series were studied by DSC and TG, powder HTXRD, thermal expansion of Sr3Bi2(BO3)4 borate was investigated by powder HTXRD. The emission spectra of Sr3Bi2(BO3)4:Eu3+ show characteristic lines attributed to the intra-configurational 4f-4f transitions in Eu3+ ions. Sr3(Bi0.85Eu0.15)2(BO3)4:Eu3+ demonstrates the strongest luminescent intensity among studied in this work borates. It can be concluded that Sr3Bi2(BO3)4:Eu3+ is a promising red phosphor.

  9. Antibodies to Influenza A Viruses in Wintering Snow Geese (Chen caerulescens) in Texas.

    PubMed

    Wong, Jessica K; Wilcox, Benjamin R; Fojtik, Alinde; Poulson, Rebecca L; Stallknecht, David E

    2016-05-01

    Wild waterfowl in the order Anseriformes are recognized reservoirs for influenza A viruses (IAVs); however, prevalence of infection can vary greatly by species. Few isolates of IAVs have been reported from snow geese (Chen caerulescens), and generally they have not been regarded as an important component of this reservoir. In February 2013, 151 combined cloacal and oropharangeal swabs and 147 serum samples were collected from snow geese wintering on the Gulf coast of Texas. None of the swab samples tested positive by virus isolation, but antibodies to IAVs were detected in 87 (59%) birds tested by competitive blocking ELISA (bELISA). To further characterize these detected antibodies, positive samples were tested by virus microneutralization (MN) for antibodies to viruses representing 14 hemagglutinin subtypes (HA1-HA12, H14, and H15). By MN, antibodies to H1 (n = 41; 47%), H5 (n = 32; 37%), H6 (n = 49; 56%), H9 (n = 50; 57%), and H12 (n = 24; 28%) were detected. Snow goose populations have increased in North America since the 1960s, and their association with agricultural lands provides a potential indirect source of IAV infection for domestic poultry. This potential, as well as the detection of antibodies to HA subtypes H5, H9, and H12 that are not well represented in other waterfowl species, suggests that further snow geese surveillance is indicated.

  10. Bulk Modulus of Spherical Palladium Nanoparticles by Chen-Mobius Lattice Inversion Method

    NASA Astrophysics Data System (ADS)

    Abdul-Hafidh, Esam

    2015-03-01

    Palladium is a precious and rare element that belongs to the Platinum group metals (PGMS) with the lowest density and melting point. Numerous uses of Pd in dentistry, medicine and industrial applications attracted considerable investment. Preparation and characterization of palladium nanoparticles have been conducted by many researchers, but very little effort has taken place on the study of Pd physical properties, such as, mechanical, optical, and electrical. In this study, Chen-Mobius lattice inversion method is used to calculate the cohesive energy and modulus of palladium. The method was employed to calculate the cohesive energy by summing over all pairs of atoms within palladium spherical nanoparticles. The modulus is derived from the cohesive energy curve as a function of particles' sizes. The cohesive energy has been calculated using the potential energy function proposed by (Rose et al., 1981). The results are found to be comparable with previous predictions of metallic nanoparticles. This work is supported by the Royal commission at Yanbu- Saudi Arabia.

  11. Debris flow run off simulation and verification -- case study of Chen-You-Lan Watershed, Taiwan

    NASA Astrophysics Data System (ADS)

    Lin, M.-L.; Wang, K.-L.; Huang, J.-J.

    2005-06-01

    In 1996 typhoon Herb struck the central Taiwan area, causing severe debris flow in many subwatersheds of the Chen-You-Lan river watershed. More severe cases of debris flow occurred following Chi-Chi earthquake, 1999. In order to identify the potentially affected area and its severity, the ability to simulate the flow route of debris is desirable. In this research numerical simulation of debris flow deposition process had been carried out using FLO-2D adopting Chui-Sue river watershed as the study area. Sensitivity study of parameters used in the numerical model was conducted and adjustments were made empirically. The micro-geomorphic database of Chui-Sue river watershed was generated and analyzed to understand the terrain variations caused by the debris flow. Based on the micro-geomorphic analysis, the debris deposition in the Chui-Sue river watershed in the downstream area, and the position and volume of debris deposition were determined. The simulated results appeared to agree fairly well with the results of micro-geomorphic study of the area when not affected by other inflow rivers, and the trends of debris distribution in the study area appeared to be fairly consistent.

  12. Wormholes supported by phantom energy from Shan-Chen cosmological fluids

    NASA Astrophysics Data System (ADS)

    Wang, Deng; Meng, Xin-He

    2016-03-01

    In the present paper, the exact solutions of spherically symmetrical Einstein field equations describing wormholes supported by phantom energy that violates the null energy condition from Shan-Chen background fluid are obtained. We have considered the important case of the model parameter ψ ≈ 1, which corresponds to the "saturation effect", and this regime corresponds to an effective form of "asymptotic freedom" for the fluids, but occurring at cosmological rather than subnuclear scales. Then we investigate the allowed range for the values of the model parameters g and ω when the spacetime metrics describe wormholes and discuss the possible singularities of the solutions, finding that the obtained spacetimes are geodesically complete. Furthermore, we construct two traversable wormholes through matching our obtained interior solutions to the exterior Schwarzschild solutions and analyze the traversablities of the wormholes. Finally, we consider the case of anisotropic pressure and discover that the transverse pressure also crosses the phantom divide -1 with the growth of the wormhole dimension, and it tends to be the same as the radial pressure with the growth of the wormhole radius.

  13. Psychometric properties of the Revised Chen Internet Addiction Scale (CIAS-R) in Chinese adolescents.

    PubMed

    Mak, Kwok-Kei; Lai, Ching-Man; Ko, Chih-Hung; Chou, Chien; Kim, Dong-Il; Watanabe, Hiroko; Ho, Roger C M

    2014-10-01

    The Revised Chen Internet Addiction Scale (CIAS-R) was developed to assess Internet addiction in Chinese populations, but its psychometric properties in adolescents have not been examined. This study aimed to evaluate the factor structure and psychometric properties of CIAS-R in Hong Kong Chinese adolescents. 860 Grade 7 to 13 students (38 % boys) completed the CIAS-R, the Young's Internet Addiction Test (IAT), and the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) in a survey. The prevalence of Internet addiction as assessed by CIAS-R was 18 %. High internal consistency and inter-item correlations were reported for the CIAS-R. Results from the confirmatory factor analysis suggested a four-factor structure of Compulsive Use and Withdrawal, Tolerance, Interpersonal and Health-related Problems, and Time Management Problems. Moreover, results of hierarchical multiple regression supported the incremental validity of the CIAS-R to predict mental health outcomes beyond the effects of demographic differences and self-reported time spent online. The CIAS is a reliable and valid measure of internet addiction problems in Hong Kong adolescents. Future study is warranted to validate the cutoffs of the CIAS-R for identification of adolescents with Internet use problems who may have mental health needs.

  14. THE LITHOSPHERIC MAGNETIC FIELD ALONG THE NISHAN-GUYANG PROFILE, CHINA 6 datesYuan Jiehao1; Gu Zuowen1; Chen Bin1; Xu Rugang2; Wang Lie2; Wang Can1 1. Institute of Geophysics, China Earthquake Administration(IGP CEA), yjh810405@163.com 2. Anhui Earthquake Administration

    NASA Astrophysics Data System (ADS)

    Yuan, J.

    2014-12-01

    In order to research the lithospheric magnetic field and the magnetization structure, the geomagnetic field was surveyed along the Nishan-Guyang profile with 900 km long in the Neimenggu and Shanxi provinces in China. The distance between the adjacent geomagnetic sites is about 7 km along the profile. The geomagnetic data were analyzed, and the lithospheric magnetic field was obtained. Using the upward continuation method, the geomagnetic anomalies in different depths were obtained: the basement anomaly, the upper crust anomaly and the superficial anomaly. Basing on these geomagnetic anomalies, the magnetization structure was obtained by using the software of the ModelVision 11.0. The preliminary results show: (1) The geomagnetic anomalies have good relationship with the local geological structure. (2) The magnetization structure is related to the depth variation of the Curie interface, the values of the magnetic susceptibility, the seismic activity and the tectonic block.

  15. Drilling gas hydrates with the sea floor drill rig MARUM-MeBo

    NASA Astrophysics Data System (ADS)

    Freudenthal, Tim; Bohrmann, Gerhard; Wefer, Gerold

    2015-04-01

    Large amounts of methane are bound in marine gas hydrate deposits. Local conditions like pressure, temperature, gas and pore water compositions define the boundaries of gas hydrate stability within the ocean sediments. Depending on those conditions gas hydrates can occur within marine sediments at depth down to several hundreds of meters up to sea floor. These oceanic methane deposits are widespread along continental margins. By forming cement in otherwise soft sediments gas hydrates are stabilizing the seafloor on continental slopes. Drilling operations are required for understanding the distribution of gas hydrates as well as for sampling them to study the composition, microstructure and its geomechanical and geophysical properties. The sea floor drill rig MARUM-MeBo200 has the capability to drill down to 200 m below sea floor well within the depth of major gas hydrate occurrences at continental margins. This drill rig is a transportable sea floor drill rig that can be deployed from a variety of multi-purpose research vessels. It is deployed on the sea bed and controlled from the vessel. It is the second generation MeBo (Freudenthal and Wefer, 2013) and was developed from 2011 to 2014 by MARUM in cooperation with BAUER Maschinen GmbH. Long term experiences with the first generation MeBo70 that was operated since 2005 on 15 research expeditions largely contributed to the development of MeBo200. It was first tested in October 2014 from the research vessel RV SONNE in the North Sea. In this presentation the suitability of MARUM-MeBo for drilling marine gas hydrates is discussed. We report on experiences drilling gas hydrates on two research expeditions with MeBo70. A research expedition for sampling gas hydrates in the Danube Paleodelta with MeBo200 as well as technical developments for improving the suitability of MeBo for gas hydrate exploration works are planned within the project SUGAR3 funded by the Federal Government for Economy and Energy (BMWi). Freudenthal

  16. Probing BoNT/A Protease Exosites: Implications for Inhibitor Design and Light Chain Longevity

    PubMed Central

    2015-01-01

    Botulinum neurotoxin serotype A (BoNT/A) is one of the most lethal toxins known. Its extreme toxicity is due to its light chain (LC), a zinc protease that cleaves SNAP-25, a synaptosome-associated protein, leading to the inhibition of neuronal activity. Studies on BoNT/A LC have revealed that two regions, termed exosites, can play an important role in BoNT catalytic activity. A clear understanding of how these exosites influence neurotoxin catalytic activity would provide a critical framework for deciphering the mechanism of SNAP-25 cleavage and the design of inhibitors. Herein, based on the crystallographic structure of BoNT/A LC complexed with its substrate, we designed an α-exosite binding probe. Experiments with this unique probe demonstrated that α-exosite binding enhanced both catalytic activity and stability of the LC. These data help delineate why α-exosite binding is needed for SNAP-25 cleavage and also provide new insights into the extended lifetime observed for BoNT/A LC in vivo. PMID:25295706

  17. Synthesis and thermoluminescence properties of rare earth-doped NaMgBO3 phosphor.

    PubMed

    Khan, Z S; Ingale, N B; Omanwar, S K

    2016-05-01

    Rare earth (Dy(3+) and Sm(3+))-doped sodium magnesium borate (NaMgBO3) is synthesized by solution combustion synthesis method keeping their thermoluminescence properties in mind. The reaction produced very stable crystalline NaMgBO3:RE (RE = Dy(3+), Sm(3+)) phosphors. The phosphors are exposed to (60)Co gamma-ray radiations dose of varying rate from 5 to 25 Gy, and their TL characteristics with kinetic parameters are studied. NaMgBO3:Dy(3+) phosphor shows two peaks for lower doping concentration of Dy(3+) while it reduced to single peak for the higher concentrations of activator Dy(3+). NaMgBO3:Dy(3+) shows the major glow peak around 200 °C while NaMgBO3:Sm(3+) phosphors show two well-separated glow peaks at 200 and 332 °C respectively. The thermoluminescence intensity of these phosphors was compare with the commercially available TLD-100 (Harshaw) phosphor. The TL responses for gamma-ray radiations dose were found to be linear from 5 to 25 Gy for both phosphors while the fading in each case is calculated for the tenure of 45 days.

  18. Superhalogens beget superhalogens: a case study of (BO2)n oligomers.

    PubMed

    Kandalam, Anil K; Kiran, Boggavarapu; Jena, P; Pietsch, S; Ganteför, G

    2015-10-28

    Superhalogens belong to a class of molecules that not only mimic the chemistry of halogen atoms but also possess electron affinities that are much larger than that of chlorine, the element with the highest electron affinity in the periodic table. Using BO2 as an example and the synergy between density functional theory-based calculations and photoelectron spectroscopy experiments we demonstrate another unusual property of superhalogens. Unlike halogens, whose ability to accept an electron falls upon dimerization, B2O4, the dimer of BO2, has an electron affinity larger than that of the BO2 building block. This ability of (BO2)2 and subsequent, higher oligomers (BO2)n (n = 3 and 4), to retain their superhalogen characteristics can be traced to the enhanced bonding interactions between oxygen and boron atoms and due to the delocalization of the charge of the extra-electron over the terminal oxygen atoms. These results open the door to the design and synthesis of a new class of metal-free highly negative ions with potential for novel applications.

  19. PHOTOMETRIC PROPERTIES OF THE INTERACTING BINARY BO MONOCEROTIS: EVIDENCE FOR MAGNETIC ACTIVITY

    SciTech Connect

    Reed, Phillip A.; Yuhas, Bernard J. E-mail: byuha055@live.kutztown.edu

    2013-05-15

    BO Monocerotis (BO Mon) is a severely neglected short-period (2.23 days) Algol-type eclipsing binary star system undergoing angular momentum variations that are likely due to the evolved secondary star experiencing cycles of magnetic activity. We present the first CCD light curves of BO Mon, which were observed at the Kutztown University Observatory (Kutztown, PA) in 2012 using B, V, and I filters. The analysis presented here is the first of its kind for BO Mon and provides the first physical model of the system's parameters. We also incorporate over 40 yr of published times of minimum light to provide a new ephemeris curve and perform a period study that greatly improves, while differing significantly from, an earlier ephemeris analysis that was done more than 13 yr ago. The observed variations in BO Mon's orbital period supply evidence for mass transfer and magnetic activity and our photometric model affords the basic properties of the system for use in future photometric and spectroscopic studies.

  20. The Bo-RBC-SCID mouse model for evaluating the efficacy of anti-theilerial drugs.

    PubMed

    Hagiwara, K; Tsuji, M; Ishihara, C; Tajima, M; Kurosawa, T; Iwai, H; Takahashi, K

    1993-02-01

    We have previously developed a mouse model which allowed the proliferation of Theileria sergenti in severe combined immunodeficiency (SCID) mice with circulating bovine erythrocytes (Bo-RBC). In the present study, this model was utilized to test the efficacy of anti-theilerial drugs. Bo-RBC-SCID mice were created by giving periodic transfusions of T. sergenti-free Bo-RBC, and subsequently infecting with T. sergenti. Three anti-protozoal compounds, Pamaquine (Yamanouchi Pharmaceutical Co. Ltd), Ganaseg (Japan CIBA-GEIGY Ltd) and Buparvaquone (Coopers Animal Health Ltd), were subcutaneously administered into the mice at doses recommended for cattle therapy. Blood examinations demonstrated that all three drugs significantly reduced the level of parasitemia although Ganaseg was effective only at a dose five times higher than that recommended for cattle therapy. Administration of the drugs neither caused any sign of acute toxicity nor changed the rate of Bo-RBC in the SCID mice's circulating blood cells. The results indicate that the Bo-RBC-SCID mouse model may offer a useful in vivo system for evaluating the efficacy of anti-protozoal drugs against T. sergenti.

  1. Hydrothermal synthesis and structural investigation of a new polymorph form of NdBO3

    NASA Astrophysics Data System (ADS)

    Tekin, Berna; Güler, Halil

    2012-09-01

    The present work deals with the hydrothermal synthesis of a new polymorph form of neodymium orthoborate, NdBO3. It was obtained by dissolving 0.1875g B2O3 in 20 ml distilled water and later added to 1.8125 g Nd2O3 and the mixture was transferred to a teflon autoclave. The hydrothermal reaction was performed at 230 °C for 72 h. Characterizations of the sample were carried out by using X-Ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Thermal Analysis (DTA/TG) techniques. NdBO3 was crystallized in monoclinic system and unit cell parameters were calculated as a=11.726(1) Å, b= 6.759(2) Å, c= 9.909(4) Å, β= 114.50(0)°, and space group of C2/c. It was confirmed that NdBO3 was isostructural with the form of Er doped YBO3 (a=11.3138(3) Å, b=6.5403(2) Å, c= 9.5499(2) Å and β= 112.902(1)°) at room temperature. The other significant invention of NdBO3 was thermally stable up to 700 °C, but if the specimen was heated at 780 °C for 4 h, the monoclinic crystal structure was transformed to the aragonite form of NdBO3 (ICDD 12-756).

  2. Recent Studies and Progression of Yin Chen Hao (茵陳蒿 Yīn Chén Hāo), a Long-term Used Traditional Chinese Medicine

    PubMed Central

    Hung, Hsin-Yi; Kuo, Sheng-Chu

    2013-01-01

    Yin Chen Hao (Artemisia capillaris Thunb; 茵陳蒿 Yīn Chén Hāo) is a traditional Chinese medicine for treating hepatic disorders. This review provides recent pharmacological studies of Yin Chen Hao as well as some chemical constituents isolated from Yin Chen. PMID:24716150

  3. Chaos Generated from the Fractional-Order Complex Chen System and its Application to Digital Secure Communication

    NASA Astrophysics Data System (ADS)

    Luo, Chao; Wang, Xingyuan

    2013-04-01

    In this paper, a novel dynamic system, the fractional-order complex Chen system, is presented for the first time. Dynamic behaviors of system are studied analytically and numerically. Different routes to chaos are shown, and diverse kinds of motions are identified and exhibited by means of bifurcation diagram, portrait phase and the largest Lyapunov exponent. Secondly, an application to digital secure communication based on the novel system is proposed, in which security is enhanced by continually switching different orders of derivative in an irregular pattern. Furthermore, making full use of the advantage of high-capacity transmission of complex system, the improved digital secure communication scheme is achieved based on hybrid synchronization in coupled fractional-order complex Chen system, that means anti-synchronization in real part of state variables and projective synchronization in imaginary part, respectively. The corresponding numerical simulations demonstrate the effectiveness and feasibility of the proposed schemes.

  4. BACs-on-Beads™ (BoBs™) assay for the genetic evaluation of prenatal samples and products of conception.

    PubMed

    Grati, Francesca Romana; Vialard, François; Gross, Susan

    2015-01-01

    BACs-on-Beads™ (BoBs™) is a new emerging technology, a modification of comparative genomic hybridization that can be used to detect DNA copy number gains and losses. Here, we describe the application of two different types of BoBs™ assays: (1) Prenatal BoBs (CE-IVD) to detect the most frequent syndromes associated with chromosome microdeletions, as well as the trisomy 13, 18 and 21, and (2) KaryoLite BoBs (RUO) which can detect aneuploidy in all chromosomes by quantifying proximal and terminal regions of each chromosomal arm. The interpretation of the results by BoBsoft™ software is also described. Although BoBs™ may not have the breadth and scope to replace chromosomal microarrays (array comparative genomic hybridization and single nucleotide polymorphism array) in the prenatal setting, particularly when a fetal anomaly has been detected, it is a well suited alternative for FISH or QF-PCR because BoBs™ is comparable, if not superior in terms of cost, turnaround time (TAT) and throughput and accuracy. BoBs™ also has the ability to detect significant fetal mosaicism (≥30% with Prenatal BoBs and ≥50% with KaryoLite BoBs). However, perhaps the greatest strength of this new technology is the fact that unlike FISH or QF-PCR, it has the ability to detect common microdeletion syndromes or additional aneuploidies, both of which may be easily missed despite excellent prenatal sonography. Thus, when BoBs™ is applied in the correct clinical setting and run and analyzed in appropriate laboratories this technique can improve and augment best practices with a personalization of prenatal care.

  5. BoD services in layer 1 VPN with dynamic virtual concatenation group

    NASA Astrophysics Data System (ADS)

    Du, Shu; Peng, Yunfeng; Long, Keping

    2008-11-01

    Bandwidth-on-Demand (BoD) services are characteristic of dynamic bandwidth provisioning based on customers' resource requirement, which will be a must for future networks. BoD services become possible with the development of make-before-break, Virtual Concatenation (VCAT) and Link Capacity Adjustment Scheme (LCAS). In this paper, we introduce BoD services into L1VPN, thus the resource assigned to a L1VPN can be gracefully adjusted at various bandwidth granularities based on customers' requirement. And we propose a dynamic bandwidth adjustment scheme, which is compromise between make-before-break and VCAT&LCAS and mainly based on the latter. The scheme minimizes the number of distinct paths to support a connection between a source-destination pair, and uses make-beforebreak technology for re-optimization.

  6. Bag of Lines (BoL) for Improved Aerial Scene Representation

    SciTech Connect

    Sridharan, Harini; Cheriyadat, Anil M.

    2014-09-22

    Feature representation is a key step in automated visual content interpretation. In this letter, we present a robust feature representation technique, referred to as bag of lines (BoL), for high-resolution aerial scenes. The proposed technique involves extracting and compactly representing low-level line primitives from the scene. The compact scene representation is generated by counting the different types of lines representing various linear structures in the scene. Through extensive experiments, we show that the proposed scene representation is invariant to scale changes and scene conditions and can discriminate urban scene categories accurately. We compare the BoL representation with the popular scale invariant feature transform (SIFT) and Gabor wavelets for their classification and clustering performance on an aerial scene database consisting of images acquired by sensors with different spatial resolutions. The proposed BoL representation outperforms the SIFT- and Gabor-based representations.

  7. Bag of Lines (BoL) for Improved Aerial Scene Representation

    DOE PAGES

    Sridharan, Harini; Cheriyadat, Anil M.

    2014-09-22

    Feature representation is a key step in automated visual content interpretation. In this letter, we present a robust feature representation technique, referred to as bag of lines (BoL), for high-resolution aerial scenes. The proposed technique involves extracting and compactly representing low-level line primitives from the scene. The compact scene representation is generated by counting the different types of lines representing various linear structures in the scene. Through extensive experiments, we show that the proposed scene representation is invariant to scale changes and scene conditions and can discriminate urban scene categories accurately. We compare the BoL representation with the popular scalemore » invariant feature transform (SIFT) and Gabor wavelets for their classification and clustering performance on an aerial scene database consisting of images acquired by sensors with different spatial resolutions. The proposed BoL representation outperforms the SIFT- and Gabor-based representations.« less

  8. Crystal structure of Li3Ga(BO3)2

    PubMed Central

    Smith, Robert W.; Holman, Darien; Villa, Eric M.

    2017-01-01

    The crystal structure of trilithium gallium bis­(orthoborate), Li3Ga(BO3)2, is isotypic with Li3Al(BO3)2 in a triclinic cell in space-group type P-1. The three Li and the unique Ga atom are coordinated by four O atoms each in tetra­hedra, and the two B atoms are coordinated by three O atoms in orthoborate triangles. Chains with composition [Ga2(BO3)4]6− extend along the a axis. The Li atoms inter­leave these chains in tetra­hedral inter­stices. A comparison is made between the structure model of the title compound and that of a previously reported model for a compound with the same composition [Abdullaev & Mamedov (1972 ▸). Zh. Strukt. Khim. 13, 943–946.] PMID:28316831

  9. Crystal structure of Li3Ga(BO3)2.

    PubMed

    Smith, Robert W; Holman, Darien; Villa, Eric M

    2017-03-01

    The crystal structure of trilithium gallium bis-(orthoborate), Li3Ga(BO3)2, is isotypic with Li3Al(BO3)2 in a triclinic cell in space-group type P-1. The three Li and the unique Ga atom are coordinated by four O atoms each in tetra-hedra, and the two B atoms are coordinated by three O atoms in orthoborate triangles. Chains with composition [Ga2(BO3)4](6-) extend along the a axis. The Li atoms inter-leave these chains in tetra-hedral inter-stices. A comparison is made between the structure model of the title compound and that of a previously reported model for a compound with the same composition [Abdullaev & Mamedov (1972 ▸). Zh. Strukt. Khim. 13, 943-946.].

  10. [Academic thoughts on Practice of acupuncture and moxibustion written by CHEN Jingwen, the acupuncture master in the Republic of China].

    PubMed

    Huang, Weiping; Li, Naiqi

    2015-03-01

    Through the collection of Practice of acupuncture and moxibustion written by CHEN Jingwen, the acupuncture master in the Republic of China, the academic characteristics on acupuncture and moxibusiton were analyzed. The literature comparison method was adopted to compare the works of LUO Zhaoju, ZENG Tianzhi and LI Wenxian, etc. at the same period. It was discovered that CHEN Jingwen was the medical master who systematicly brought up the theory of acupoint properties earlier in the modern times. Classifying drugs based on acupoints was his academic feature. Additionally, the compatibility therapy of Chinese medicine was introduced to explain the essential ideas on the acupoints combination. The treatment was determined on the basis of zangxiang theory and the reinforcing and reducing therapy of acupuncture was emphasized in the determination of treatment and prescription. CHEN Jingwen's theory of acupoint property had been stressed and spread among the medical scholars in the Republic of China and he had made the beneficial exploration for the development of modern acupuncture and moxibustion therapy.

  11. Moult migration of emperor geese Chen canagica between Alaska and Russia

    USGS Publications Warehouse

    Hupp, J.W.; Schmutz, J.A.; Ely, C.R.; Syroechkovskiy, E.E.; Kondratyev, Alexander V.; Eldridge, W.D.; Lappo, E.

    2007-01-01

    We studied reproductive success and post-breeding movements of 32 adult female emperor geese Chen canagica that were marked with satellite radio transmitters on their nesting area on the Yukon-Kuskokwim Delta (YKD), Alaska 2000–2004. All 16 females that failed to successfully reproduce departed the YKD and moulted remiges either on the north coast of the Chukotka Peninsula, Russia (n=15), or on St. Lawrence Island, Alaska (n=1). Of 16 females that successfully nested, one migrated to Russia following hatch whereas the remainder stayed on the YKD. While moulting on the Chukotka Peninsula, emperor geese with satellite transmitters primarily used coastal lagoons west of Kolyuchin Bay. We observed 21,150 adult-plumaged emperor geese during aerial surveys in Chukotka in 2002. Most (95%) were in the same region used by geese that had been marked with satellite transmitters in Alaska. The number of emperor geese observed in Russia was comparable to our estimate of ≥20,000 adults that either do not nest or nest unsuccessfully each year on the YKD, suggesting that most nonproductive adults, or ≥28% of the adult population departs the YKD to moult elsewhere. The number of moult migrants may be substantially higher in years of poor reproductive success or if adult-plumaged birds that are not of breeding age also leave the YKD. Moult migration of emperor geese between Alaska and Russia is likely substantially greater than previously believed. Russian moulting habitats are important to the North American population of emperor geese and events that affect survival of geese in Russia could impact population trends on the YKD. Protection of coastal lagoons on the north coast of Chukotka is warranted.

  12. BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva.

    PubMed

    Svitek, N; Awino, E; Nene, V; Steinaa, L

    2015-09-15

    We have recently shown that the BoLA-A18 variant haplotype (BoLA-6*01302) is more prevalent than the BoLA-A18 haplotype (BoLA-6*01301) in a sample of Holstein/Friesian cattle in Kenya. These MHC class I allelic variants differ by a single amino acid polymorphism (Glu97 to Leu97) in the peptide-binding groove. We have previously mapped an 11-mer peptide epitope from the Theileria parva antigen Tp1 (Tp1214-224) that is presented by BoLA-6*01301. Crystal structure data indicates that Glu97 in the MHC molecule plays a role in epitope binding through electro-static interaction with a lysine residue in position 5 of the epitope, which also functions as an additional anchor residue. In contrast to expectations, we demonstrate that the amino acid substitution in BoLA-6*01302 does not divert the CTL response away from Tp1214-224. The two MHC molecules exhibit similar affinity for the Tp1 epitope and can present the epitope to parasite-specific CTLs derived from either BoLA allelic variants. These data confirm that this BoLA polymorphism does not alter Tp1 epitope specificity and that both allelic variants can be used for Tp1 vaccine studies. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  13. The role of BoFLC2 in cauliflower (Brassica oleracea var. botrytis L.) reproductive development

    PubMed Central

    Ridge, Stephen; Brown, Philip H.; Hecht, Valérie; Driessen, Ronald G.; Weller, James L.

    2015-01-01

    In agricultural species that are sexually propagated or whose marketable organ is a reproductive structure, management of the flowering process is critical. Inflorescence development in cauliflower is particularly complex, presenting unique challenges for those seeking to predict and manage flowering time. In this study, an integrated physiological and molecular approach was used to clarify the environmental control of cauliflower reproductive development at the molecular level. A functional allele of BoFLC2 was identified for the first time in an annual brassica, along with an allele disrupted by a frameshift mutation (boflc2). In a segregating F2 population derived from a cross between late-flowering (BoFLC2) and early-flowering (boflc2) lines, this gene behaved in a dosage-dependent manner and accounted for up to 65% of flowering time variation. Transcription of BoFLC genes was reduced by vernalization, with the floral integrator BoFT responding inversely. Overall expression of BoFT was significantly higher in early-flowering boflc2 lines, supporting the idea that BoFLC2 plays a key role in maintaining the vegetative state. A homologue of Arabidopsis VIN3 was isolated for the first time in a brassica crop species and was up-regulated by two days of vernalization, in contrast to findings in Arabidopsis where prolonged exposure to cold was required to elicit up-regulation. The correlations observed between gene expression and flowering time in controlled-environment experiments were validated with gene expression analyses of cauliflowers grown outdoors under ‘natural’ vernalizing conditions, indicating potential for transcript levels of flowering genes to form the basis of predictive assays for curd initiation and flowering time. PMID:25355864

  14. Prenatal BoBsTM in the cytogenetic analysis of products of spontaneous miscarriage.

    PubMed

    Mellali, Sarah; Haoud, Khadidja; Gouas, Laetitia; Khaled, Meghit Boumediene; Vago, Philippe; Moulessehoul, Soraya

    2015-09-19

    Fifty percent of spontaneous miscarriages (SMs) are attributed to chromosomal abnormalities. Cytogenetic analysis is an important tool for patient counselling and assessment of the risk of recurrence in future pregnancies. Conventional karyotyping has been the gold standard for chromosomal investigation of products of conception (POC), but it has limitations due to sample maceration, culture failure and maternal cell contamination. Molecular cytogenetic approaches have therefore been developed and found valuable in the cytogenetic investigation of these samples. The Prenatal BoBsTM and KaryoLite BoBsTM, based on the newly developed BACs-on-BeadsTM technology, have been described as reliable tests for rapid detection of aneuploidies in prenatal and POC samples, respectively. To describe our clinical experience of routine screening of POC samples with Prenatal BoBsTM, the test used by our laboratory in France. Seventeen samples collected at the University Hospital of Sidi Bel Abbès (Western Algeria) and a further 60 from the University Hospital of Clermont-Ferrand (France) were analysed (19 chorionic villi from products of curettage, 12 placentas, 9 amniotic cells and 37 biopsy specimens). All were screened for the frequent aneuploidies (chromosomes 13, 18, 21, X and Y) in addition to nine microdeletion/microduplication syndrome regions by Prenatal BoBsTM. Standard karyotyping was performed on 51 samples, but failed in 38 cases. Prenatal BoBsTM identified one trisomy 21 and one deletion of 17p13.3. Furthermore, it provided a conclusive result in cases of culture failure (n=38) and in samples with macerated tissue (n=19). The overall failure rate was 11.4%. Prenatal BoBsTM is a promising technology that represents a fast, sensitive and robust alternative to routine screening for chromosomal abnormality in products of SM. Furthermore, it overcomes the limitations of conventional karyotyping and current molecular cytogenetic techniques.

  15. Inpatient healthcare provider bypassing by women and their children in urban Bo, Sierra Leone

    PubMed Central

    Fleming, Lila C; Ansumana, Rashid; Bockarie, Alfred; Alejandre, Joel; Bangura, Umaru; Jimmy, David Henry; Waters, Nigel; Baghi, Heibatollah; Stenger, David; Jacobsen, Kathryn H

    2016-01-01

    Introduction Bypassing refers to a person's decision to seek care at a healthcare facility that is not the nearest one of its type to the person's home. Methods This study examined inpatient care facility bypassing in urban Bo, Sierra Leone using data from 1,980 women with children 15 years of age and younger who were interviewed in 2010-2011. The locations of residential structures and hospitals were identified using a geographic information system (GIS), and the road distances from participating households to the nearest and preferred inpatient care facilities were measured. Results Nine inpatient care facilities serve Bo residents, but more than 70% of the participating women reported that the city's main public hospital (Bo Government Hospital), located in the city center, was their preferred inpatient care provider. Participants resided within a median distance of 0.9 km (Interquartile range (IQR): 0.6, 1.8) from their closest inpatient facility, but they would travel a median distance of 2.4 km (IQR: 1.0, 3.3) to reach their preferred providers. About 87% of the women would bypass their nearest inpatient care facility to access care at a preferred provider. Bypassing rates were similar for various demographic and socioeconomic groups, but higher for women living farther from the city center. Conclusion Although Bo has a diverse healthcare marketplace, access to affordable advanced care options is limited. Most women in Bo would choose to bypass facilities nearer to their homes to seek the low-cost and comprehensive care offered by Bo Government Hospital. PMID:27279971

  16. The role of BoFLC2 in cauliflower (Brassica oleracea var. botrytis L.) reproductive development.

    PubMed

    Ridge, Stephen; Brown, Philip H; Hecht, Valérie; Driessen, Ronald G; Weller, James L

    2015-01-01

    In agricultural species that are sexually propagated or whose marketable organ is a reproductive structure, management of the flowering process is critical. Inflorescence development in cauliflower is particularly complex, presenting unique challenges for those seeking to predict and manage flowering time. In this study, an integrated physiological and molecular approach was used to clarify the environmental control of cauliflower reproductive development at the molecular level. A functional allele of BoFLC2 was identified for the first time in an annual brassica, along with an allele disrupted by a frameshift mutation (boflc2). In a segregating F₂ population derived from a cross between late-flowering (BoFLC2) and early-flowering (boflc2) lines, this gene behaved in a dosage-dependent manner and accounted for up to 65% of flowering time variation. Transcription of BoFLC genes was reduced by vernalization, with the floral integrator BoFT responding inversely. Overall expression of BoFT was significantly higher in early-flowering boflc2 lines, supporting the idea that BoFLC2 plays a key role in maintaining the vegetative state. A homologue of Arabidopsis VIN3 was isolated for the first time in a brassica crop species and was up-regulated by two days of vernalization, in contrast to findings in Arabidopsis where prolonged exposure to cold was required to elicit up-regulation. The correlations observed between gene expression and flowering time in controlled-environment experiments were validated with gene expression analyses of cauliflowers grown outdoors under 'natural' vernalizing conditions, indicating potential for transcript levels of flowering genes to form the basis of predictive assays for curd initiation and flowering time.

  17. Aktivitätsmessung auf nukleinsäuremodifizierten Oberflächen

    NASA Astrophysics Data System (ADS)

    Schmidt, Peter Michael

    2003-06-01

    Im Bereich der medizinischen Diagnostik spielen DNA-Chips eine immer wichtigere Rolle. Dabei werden Glas- oder Silikon-Oberflächen mit Tausenden von einzelsträngigen DNA-Fragmenten, sog. Sonden, bestückt, die mit den passenden DNA-Fragmenten in der zugefügten Patientenprobe verschmelzen. Die Auswertung solcher Messungen liefert die Diagnose für Krankheiten wie z.B. Krebs, Alzheimer oder für den Nachweis pathogener Erreger. Durch fortschreitende Miniaturisierung dieser Meßsysteme können bis zu 40.000 Genfragmente des Menschen in einer einzigen Messung analysiert werden. Neben den DNA-Fragmenten können Bio-Chips auch für andere biologische Komponenten wie Antikörper und Proteine eingesetzt werden, wobei bei letzteren neben der Bindung auch die Aktivität ein wichtiger Diagnoseparamter ist. Am Fraunhofer-Institut für medizinische Technik und am Lehrstuhl für Analytische Biochemie der Universität Potsdam wurden im Rahmen einer Doktorarbeit Methoden entwickelt, die es ermöglichen auf nukleinsäuremodifizierten Sensoroberflächen die Aktivität von Proteinen zu messen. Es wurden Nukleinsäuren auf Oberflächen optischer Sensoren verankert. Diese fungierten als Rezeptor für die Proteine sowie auch als Substrat für Restriktionsenzyme, die Nukleinsäuren schneiden und Polymerasen, die Nukleinsäuren synthetisieren und verlängern können. Seine Anwendung fand diese Messmethode in der Messung der Aktivität des Proteins Telomerase, das in 90% aller Tumore erhöhte Aktivität gegenüber gesunden Zellen aufweist. Die Vorteile dieses neuen Assays gegenüber älteren Methoden liegt im Verzicht auf radioaktiv-markierten Komponenten und einer deutlich verkürzten Analysezeit. Die Arbeit schliesst mit einem funktionsfähigen Nachweis der Telomeraseaktivität im Zellextrakt von gesunden und kranken Zellen. Der direkte Einfluß von Hemmstoffen auf die Aktivität konnte sichtbar gemacht werden, und steht daher bei der Entwicklung neuer Tumor-Diagnostika und

  18. Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

    PubMed Central

    Staats, Herman F.; Fielhauer, Jeffrey R.; Thompson, Afton L.; Tripp, Alice A.; Sobel, Ashley E.; Maddaloni, Massimo; Abraham, Soman N.; Pascual, David W.

    2011-01-01

    Background We previously reported that the immunogenicity of Hcβtre, a botulinum neurotoxin A (BoNT/A) immunogen, was enhanced by fusion to an epithelial cell binding domain, Ad2F, when nasally delivered to mice with cholera toxin (CT). This study was performed to determine if Ad2F would enhance the nasal immunogenicity of Hcβtre in rabbits, an animal model with a nasal cavity anatomy similar to humans. Since CT is not safe for human use, we also tested the adjuvant activity of compound 48/80 (C48/80), a mast cell activating compound previously determined to safely exhibit nasal adjuvant activity in mice. Methods New Zealand White or Dutch Belted rabbits were nasally immunized with Hcβtre or Hcβtre-Ad2F alone or combined with CT or C48/80, and serum samples were tested for the presence of Hcβtre-specific binding (ELISA) or BoNT/A neutralizing antibodies. Results Hcβtre-Ad2F nasally administered with CT induced serum anti-Hcβtre IgG ELISA and BoNT/A neutralizing antibody titers greater than those induced by Hcβtre + CT. C48/80 provided significant nasal adjuvant activity and induced BoNT/A-neutralizing antibodies similar to those induced by CT. Conclusions Ad2F enhanced the nasal immunogenicity of Hcβtre, and the mast cell activator C48/80 was an effective adjuvant for nasal immunization in rabbits, an animal model with a nasal cavity anatomy similar to that in humans. PMID:21304600

  19. Security analysis of boolean algebra based on Zhang-Wang digital signature scheme

    NASA Astrophysics Data System (ADS)

    Zheng, Jinbin

    2014-10-01

    In 2005, Zhang and Wang proposed an improvement signature scheme without using one-way hash function and message redundancy. In this paper, we show that this scheme exits potential safety concerns through the analysis of boolean algebra, such as bitwise exclusive-or, and point out that mapping is not one to one between assembly instructions and machine code actually by means of the analysis of the result of the assembly program segment, and which possibly causes safety problems unknown to the software.

  20. Protein folding of the H0P model: A parallel Wang-Landau study

    SciTech Connect

    Shi, Guangjie; Wuest, Thomas; Li, Ying Wai; Landau, David P

    2015-01-01

    We propose a simple modication to the hydrophobic-polar (HP) protein model, by introducing a new type of monomer, "0", with intermediate hydrophobicity of some amino acids between H and P. With the replica-exchange Wang-Landau sampling method, we investigate some widely studied HP sequences as well as their H0P counterparts and observe that the H0P sequences exhibit dramatically reduced ground state degeneracy and more signicant transition signals at low temperature for some thermodynamic properties, such as the specific heat.

  1. Difference of energy density of states in the Wang-Landau algorithm.

    PubMed

    Komura, Yukihiro; Okabe, Yutaka

    2012-01-01

    Paying attention to the difference of density of states, Δln g(E)≡ln g(E+ΔE)-lng(E), we study the convergence of the Wang-Landau method. We show that this quantity is a good estimator to discuss the errors of convergence and refer to the 1/t algorithm. We also examine the behavior of the first-order transition with this difference of density of states in connection with Maxwell's equal area rule. A general procedure to judge the order of transition is given.

  2. Conodont index fossil Hindeodus changxingensis Wang fingers greatest mass extinction event

    USGS Publications Warehouse

    Metcalfe, I.; Nicoll, R.S.; Wardlaw, B.R.

    2007-01-01

    The marine conodont fossil species, Hindeodus changxingensis Wang, that has a distinctive morphology, is restricted to a very narrow stratigraphic interval essentially from the Permian-Triassic extinction event through the internationally recognized boundary and into the very earliest Triassic. The species is geographically widespread in the Tethyan Region, from Italy to South China, and serves as a characteristic index fossil to reliably identify this short but critical interval that encompasses the greatest mass extinction of life on earth and the boundary between the Paleozoic and Mesozoic Eras. ?? 2007 Nanjing Institute of Geology and Palaeontology, CAS.

  3. An L1-script-transfer-effect fallacy: a rejoinder to Wang et al. (2003).

    PubMed

    Yamada, Jun

    2004-09-01

    Do different L1 (first language) writing systems differentially affect word identification in English as a second language (ESL)? Wang, Koda, and Perfetti [Cognition 87 (2003) 129] answered yes by examining Chinese students with a logographic L1 background and Korean students with an alphabetic L1 background for their phonological and orthographic processing skills on English word identification. Such a conclusion is premature, however. We propose that the L1 phonological system (rather than the L1 writing system) of the learner largely accounts for cognitive processes in learning to read a second language (L2).

  4. Wang-Landau Algorithm for Continuous Models and Joint Density of States

    SciTech Connect

    Zhou, Chenggang; Schulthess, Thomas C; Torbrugge, S.; Landau, D. P.

    2006-01-01

    We present a modified Wang-Landau algorithm for models with continuous degrees of freedom. We demonstrate this algorithm with the calculation of the joint density of states of ferromagnet Heisenberg models and a model polymer chain. The joint density of states contains more information than the density of states of a single variable-energy, but is also much more time consuming to calculate. We present strategies to significantly speed up this calculation for large systems over a large range of energy and order parameter.

  5. Wang-Landau algorithm for continuous models and joint density of states.

    PubMed

    Zhou, Chenggang; Schulthess, T C; Torbrügge, Stefan; Landau, D P

    2006-03-31

    We present a modified Wang-Landau algorithm for models with continuous degrees of freedom. We demonstrate this algorithm with the calculation of the joint density of states of ferromagnet Heisenberg models and a model polymer chain. The joint density of states contains more information than the density of states of a single variable-energy, but is also much more time consuming to calculate. We present strategies to significantly speed up this calculation for large systems over a large range of energy and order parameter.

  6. Unraveling the Beautiful Complexity of Simple Lattice Model Polymers and Proteins Using Wang-Landau Sampling

    NASA Astrophysics Data System (ADS)

    Wüst, T.; Li, Y. W.; Landau, D. P.

    2011-08-01

    We describe a class of "bare bones" models of homopolymers which undergo coil-globule collapse and proteins which fold into their native states in free space or into denatured states when captured by an attractive substrate as the temperature is lowered. We then show how, with the use of a properly chosen trial move set, Wang-Landau Monte Carlo sampling can be used to study the rough free energy landscape and ground (native) states of these intriguingly simple systems and thus elucidate their thermodynamic complexity.

  7. A Wang-Landau study of the phase transitions in a flexible homopolymer

    NASA Astrophysics Data System (ADS)

    Seaton, D. T.; Wüst, T.; Landau, D. P.

    2009-04-01

    Using Wang-Landau sampling we study the characteristic behavior of a flexible homopolymer (off-lattice) for chain lengths up to N=300. The Hamiltonian consists of a Lennard-Jones potential between all monomers, and an additional FENE potential between bonded monomers. From the resultant density of states, we calculate thermodynamic properties for a wide range of temperatures, including low temperatures that are inaccessible to traditional Monte Carlo algorithms. Peaks in the specific heat and radius of gyration indicate the coil-globule and solid-liquid transitions. With a careful implementation of the algorithm, we find no evidence of a liquid-liquid transition.

  8. Two-Dimensional Wang-Landau Sampling of AN Asymmetric Ising Model

    NASA Astrophysics Data System (ADS)

    Tsai, Shan-Ho; Wang, Fugao; Landau, D. P.

    We study the critical endpoint behavior of an asymmetric Ising model with two- and three-body interactions on a triangular lattice, in the presence of an external field. We use a two-dimensional Wang-Landau sampling method to determine the density of states for this model. An accurate density of states allowed us to map out the phase diagram accurately and observe a clear divergence of the curvature of the spectator phase boundary and of the derivative of the magnetization coexistence diameter near the critical endpoint, in agreement with previous theoretical predictions.

  9. Conformational transitions of a confined lattice protein: A Wang-Landau study

    NASA Astrophysics Data System (ADS)

    Pattanasiri, Busara; Li, Ying Wai; Landau, David P.; Wüst, Thomas; Triampo, Wannapong

    2012-12-01

    We use Wang-Landau sampling with suitable Monte Carlo trial moves to study a hydrophobic-polar (HP) lattice protein confined between two parallel, attractive walls. The density of states is determined iteratively by a random walk in energy space. Thermodynamic and structural properties, such as specific heat, number of surface contacts and number of H-H monomer pairs, are then calculated. When the surface attraction is comparable to the internal attraction among the hydrophobic monomers in the chain, two conformational “transitions”, adsorption at higher temperature and collapse at lower temperature, have been analyzed based on these properties. This transition behavior depends on the variation of surface separation.

  10. Wang-Landau Algorithm for Continuous Models and Joint Density of States

    NASA Astrophysics Data System (ADS)

    Zhou, Chenggang; Schulthess, T. C.; Torbrügge, Stefan; Landau, D. P.

    2006-03-01

    We present a modified Wang-Landau algorithm for models with continuous degrees of freedom. We demonstrate this algorithm with the calculation of the joint density of states of ferromagnet Heisenberg models and a model polymer chain. The joint density of states contains more information than the density of states of a single variable-energy, but is also much more time consuming to calculate. We present strategies to significantly speed up this calculation for large systems over a large range of energy and order parameter.

  11. [Analysis on professor WANG Juyi's crevice theory from Tao Teh King].

    PubMed

    Luo, Lu; Wang, Juyi

    2015-10-01

    The crevice theory proposed by professor WANG Juyi is analyzed in this article. In the crevice theory, it is believed that the meridians are located among "skin, pulse, flesh, tendon and bone", and the crevice is the path for the transportation of qi-blood and body fluid in the body, which is the essential condition for vital movement. This is in agreement with the idea of "action through inaction" from Tao Teh King. Based on crevice theory, the abnormalities of meridians can reflex the deficiency and excess of diseases, and regulating meridians is a significant way to treat diseases, and maintaining smooth meridian is important for healthcare.

  12. Determination of the conformal-field-theory central charge by the Wang-Landau algorithm

    NASA Astrophysics Data System (ADS)

    Belov, P. A.; Nazarov, A. A.; Sorokin, A. O.

    2017-06-01

    We present a simple method to estimate the central charge of the conformal field theory corresponding to a critical point of a two-dimensional lattice model from Monte Carlo simulations. The main idea is to use the Wang-Landau flat-histogram algorithm, which allows us to obtain the free energy of a lattice model on a torus as a function of torus radii. The central charge is calculated with good precision from a free-energy scaling at the critical point. We apply the method to the Ising, tricritical Ising (Blume-Capel), Potts, and site-diluted Ising models, and we also discuss an estimation of the conformal weights.

  13. Security analysis of boolean algebra based on Zhang-Wang digital signature scheme

    SciTech Connect

    Zheng, Jinbin

    2014-10-06

    In 2005, Zhang and Wang proposed an improvement signature scheme without using one-way hash function and message redundancy. In this paper, we show that this scheme exits potential safety concerns through the analysis of boolean algebra, such as bitwise exclusive-or, and point out that mapping is not one to one between assembly instructions and machine code actually by means of the analysis of the result of the assembly program segment, and which possibly causes safety problems unknown to the software.

  14. Area negative thermal expansion in a beryllium borate LiBeBO3 with edge sharing tetrahedra.

    PubMed

    Yao, Wenjiao; Jiang, Xingxing; Huang, Rongjin; Li, Wei; Huang, Chuanjun; Lin, Zheshuai; Li, Laifeng; Chen, Chuangtian

    2014-11-14

    A very rare area negative thermal expansion phenomenon is observed in a newly discovered alkali beryllium borate LiBeBO3, which is characterized by [BeBO3]∞ double layers intraconnected by edge-sharing BeO4 tetrahedra. This unusual thermal behavior is attributed to the combined vibrational effects of the abnormal Be-O structures and Li(+) cations.

  15. [Variation of the BoLA-DRB3 gene in dairy cattle and its effect on the viability parameters].

    PubMed

    Kovaliuk, N V; Satsuk, V F; Volchenko, A E

    2012-08-01

    Genotyping of the BoLA-DRB3 alleles was performed in dairy cattle of Krasnodar krai and Holstein stud bulls. Loss of heterozygosity, which decreased the reproductive parameters, was observed. It was proposed that stud bulls be selected on the basis of their genotyping at the BoLA-DRB3 gene to prevent further decay of cattle viability.

  16. Pb2 BO3 Cl: A Tailor-Made Polar Lead Borate Chloride with Very Strong Second Harmonic Generation.

    PubMed

    Zou, Guohong; Lin, Chensheng; Jo, Hongil; Nam, Gnu; You, Tae-Soo; Ok, Kang Min

    2016-09-19

    A meticulously designed, polar, non-centrosymmetric lead borate chloride, Pb2 BO3 Cl, was synthesized using KBe2 BO3 F2 (KBBF) as a model. Single-crystal X-ray diffraction revealed that the structure of Pb2 BO3 Cl consists of cationic [Pb2 (BO3 )](+) honeycomb layers and Cl(-) anions. Powder second harmonic generation (SHG) measurements on graded polycrystalline Pb2 BO3 Cl indicated that the title compound is phase-matchable (type I) and exhibits a remarkably strong SHG response, which is approximately nine times stronger than that of potassium dihydrogen phosphate, and the largest efficiency observed in materials with structures similar to KBBF. Further characterization suggested that the compound melts congruently at high temperature and has a wide transparency window from the near-UV to the mid-IR region.

  17. Joint report of the Third International Bovine Lymphocyte Antigen (BoLA) Workshop, Helsinki, Finland, 27 July 1986.

    PubMed

    Bull, R W; Lewin, H A; Wu, M C; Peterbaugh, K; Antczak, D; Bernoco, D; Cwik, S; Dam, L; Davies, C; Dawkins, R L

    1989-01-01

    Two hundred and eighty-two alloantisera were submitted by 20 participating laboratories from 13 countries and tested against lymphocytes of 1298 cattle. The cell panel consisted of samples from 38 Bos taurus breeds, 11 Bos taurus crossbreeds, 4 Bos indicus breeds, 6 Bos taurus x Bos indicus, and a variety of other crossbred populations. Using a standardized lymphocytotoxicity test, all 17 previously identified BoLA specificities were confirmed. The workshop produced agreement on 16 new lymphocyte alloantigenic specificities. Three of the new specificities behaved as splits of previously identified BoLA specificities. Four of the new specificities behaved as alleles at the agreed BoLA-A locus. Seven new specificities are tentatively assigned to the BoLA-A locus but require further definition. Two new specificities may represent products of a second closely-linked BoLA locus.

  18. The spatial and temporal expression of Ch-en, the engrailed gene in the polychaete Chaetopterus, does not support a role in body axis segmentation

    NASA Technical Reports Server (NTRS)

    Seaver, E. C.; Paulson, D. A.; Irvine, S. Q.; Martindale, M. Q.

    2001-01-01

    We are interested in understanding whether the annelids and arthropods shared a common segmented ancestor and have approached this question by characterizing the expression pattern of the segment polarity gene engrailed (en) in a basal annelid, the polychaete Chaetopterus. We have isolated an en gene, Ch-en, from a Chaetopterus cDNA library. Genomic Southern blotting suggests that this is the only en class gene in this animal. The predicted protein sequence of the 1.2-kb cDNA clone contains all five domains characteristic of en proteins in other taxa, including the en class homeobox. Whole-mount in situ hybridization reveals that Ch-en is expressed throughout larval life in a complex spatial and temporal pattern. The Ch-en transcript is initially detected in a small number of neurons associated with the apical organ and in the posterior portion of the prototrochophore. At later stages, Ch-en is expressed in distinct patterns in the three segmented body regions (A, B, and C) of Chaetopterus. In all segments, Ch-en is expressed in a small set of segmentally iterated cells in the CNS. In the A region, Ch-en is also expressed in a small group of mesodermal cells at the base of the chaetal sacs. In the B region, Ch-en is initially expressed broadly in the mesoderm that then resolves into one band/segment coincident with morphological segmentation. The mesodermal expression in the B region is located in the anterior region of each segment, as defined by the position of ganglia in the ventral nerve cord, and is involved in the morphogenesis of segment-specific feeding structures late in larval life. We observe banded mesodermal and ectodermal staining in an anterior-posterior sequence in the C region. We do not observe a segment polarity pattern of expression of Ch-en in the ectoderm, as is observed in arthropods. Copyright 2001 Academic Press.

  19. The spatial and temporal expression of Ch-en, the engrailed gene in the polychaete Chaetopterus, does not support a role in body axis segmentation

    NASA Technical Reports Server (NTRS)

    Seaver, E. C.; Paulson, D. A.; Irvine, S. Q.; Martindale, M. Q.

    2001-01-01

    We are interested in understanding whether the annelids and arthropods shared a common segmented ancestor and have approached this question by characterizing the expression pattern of the segment polarity gene engrailed (en) in a basal annelid, the polychaete Chaetopterus. We have isolated an en gene, Ch-en, from a Chaetopterus cDNA library. Genomic Southern blotting suggests that this is the only en class gene in this animal. The predicted protein sequence of the 1.2-kb cDNA clone contains all five domains characteristic of en proteins in other taxa, including the en class homeobox. Whole-mount in situ hybridization reveals that Ch-en is expressed throughout larval life in a complex spatial and temporal pattern. The Ch-en transcript is initially detected in a small number of neurons associated with the apical organ and in the posterior portion of the prototrochophore. At later stages, Ch-en is expressed in distinct patterns in the three segmented body regions (A, B, and C) of Chaetopterus. In all segments, Ch-en is expressed in a small set of segmentally iterated cells in the CNS. In the A region, Ch-en is also expressed in a small group of mesodermal cells at the base of the chaetal sacs. In the B region, Ch-en is initially expressed broadly in the mesoderm that then resolves into one band/segment coincident with morphological segmentation. The mesodermal expression in the B region is located in the anterior region of each segment, as defined by the position of ganglia in the ventral nerve cord, and is involved in the morphogenesis of segment-specific feeding structures late in larval life. We observe banded mesodermal and ectodermal staining in an anterior-posterior sequence in the C region. We do not observe a segment polarity pattern of expression of Ch-en in the ectoderm, as is observed in arthropods. Copyright 2001 Academic Press.

  20. Low temperature preparation and characterization of In 1- xLn xBO 3 ( x = 0.0 and 0.05; Ln = Gd, Eu, Dy and Sm): ESR of In 0.95Gd 0.05BO 3 and emission of In 0.95Eu 0.05BO 3

    NASA Astrophysics Data System (ADS)

    Velchuri, Radha; Vijaya Kumar, B.; Rama Devi, V.; Ravi Kumar, K.; Prasad, G.; Vithal, M.

    2009-10-01

    Indium borate and rare earth substituted indium borates (In 1- xLn xBO 3 ( x = 0.0 and 0.05; Ln = Gd, Eu, Dy and Sm)) are prepared at low temperature by metathesis reaction using InCl 3, LnCl 3 and NaBO 2. They are characterized by powder XRD and infrared spectroscopy. All the compositions (In 1- xLn xBO 3) crystallize in hexagonal lattice with calcite structure. These borates gave characteristic IR vibrations of planar BO 3 group. Spin-Hamiltonian parameters for Gd 3+ are deduced from room temperature electron spin resonance spectrum of In 0.95Gd 0.05BO 3. The electron spin resonance spectrum of In 0.95Gd 0.05BO 3 gave several anisotropic lines with g > 2.0. The ESR spectrum of the sample belongs to the "intermediate" category with 1/4 < HCF/ hν < 1. The local symmetry of Eu 3+ in In 0.95Eu 0.05BO 3 is obtained from its emission spectrum. The R/O ratio of In 0.95Eu 0.05BO 3 suggests the occupation of In 3+ site by Eu 3+ with near symmetric octahedral geometry.

  1. Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower.

    PubMed

    Chiu, Li-Wei; Li, Li

    2012-10-01

    Purple cauliflower (Brassica oleracea L. var. botrytis) Graffiti represents a unique mutant in conferring ectopic anthocyanin biosynthesis, which is caused by the tissue-specific activation of BoMYB2, an ortholog of Arabidopsis PAP2 or MYB113. To gain a better understanding of the regulatory network of anthocyanin biosynthesis, we investigated the interaction among cauliflower MYB-bHLH-WD40 network proteins and examined the interplay of BoMYB2 with various bHLH transcription factors in planta. Yeast two-hybrid studies revealed that cauliflower BoMYBs along with the other regulators formed the MYB-bHLH-WD40 complexes and BobHLH1 acted as a bridge between BoMYB and BoWD40-1 proteins. Different BoMYBs exhibited different binding activity to BobHLH1. Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Expression of BoMYB2 in Arabidopsis caused up-regulation of AtTT8 and AtEGL3 as well as a subset of anthocyanin structural genes encoding flavonoid 3'-hydroxylase, dihydroflavonol 4-reductase, and leucoanthocyanidin dioxygenase. Taken together, our results show that MYB-bHLH-WD40 network transcription factors regulated the bHLH gene expression, which may represent a critical feature in the control of anthocyanin biosynthesis. BoMYB2 together with various BobHLHs specifically regulated the late anthocyanin biosynthetic pathway genes for anthocyanin biosynthesis. Our findings provide additional information for the complicated regulatory network of anthocyanin biosynthesis and the transcriptional regulation of transcription factors in vegetable crops.

  2. Effect of "Deqi" during the Study of Needling "Wang's Jiaji" Acupoints Treating Spasticity after Stroke.

    PubMed

    Li, Huanqin; Liu, Huilin; Liu, Cunzhi; Shi, Guangxia; Zhou, Wei; Zhao, Chengmei; Zhang, Tao; Wang, Xuefei; Wang, Guiling; Zhao, Yin; Sun, Jingqing; Wang, Jing; Wang, Linpeng

    2014-01-01

    Background. Acupuncture has been shown to reduce spasticity and prevent the onset of spasticity after stroke. The purpose of this study is to assess the effect of "Deqi" during needling "Wang's Jiaji" acupoints treating spasticity in the early stage of stroke. Methods. This study is a multicenter, prospective, randomized, controlled trial. 238 patients with stroke (<21 days) participated and were randomly allocated to the verum-acupuncture (n = 121) group or sham-acupuncture group (n = 117). The verum-acupuncture group received verum acupuncture required to produce the sense of "Deqi" while the sham-acupuncture group received sham acupuncture without "Deqi." Patients in both groups followed the same 30 min acupuncture regimen 5 times per week for a period of 4 weeks. Scales of MAS, FMA, ADL, MBI, NIHSS, SS-QOL, and MRS were measured at baseline and at 2, 4, and 12 weeks after intervention. Results. Significant differences were observed between two groups. The MRS rating composition has the statistical difference after 4 weeks (P = 0.017). The score of MAS, FMA, Barthel, and SSQOL in verum-acupuncture group has increased significantly compared with the sham-acupuncture group after 12 weeks. There was 14% reduction of higher muscle tension in the verum-acupuncture group. Conclusion. Acupuncture "Wang's Jiaji" points with sensation of "Deqi" in the early stage may reduce the occurrence and decrease the severity of spasticity after stroke.

  3. Replica-exchange Wang-Landau simulations of the H0P model of protein folding

    NASA Astrophysics Data System (ADS)

    Shi, Guangjie; Landau, David P.; Wüst, Thomas; Li, Ying Wai Li

    2015-03-01

    The hydrophobic-polar (HP) model has served as a coarse-grained lattice protein folding model attracting scientists from various disciplines. However, simplification into H and P monomers may yield high ground state degeneracies which stands in contrast to the generally unique native states of natural proteins. We propose a simple modification, by introducing a new type of ``neutral'' monomer, 0, i.e. neither hydrophobic nor polar, rendering the model more realistic without increasing the difficulties of sampling significantly. With the newly developed parallel Wang-Landau (replica exchange Wang-Landau) scheme and an innovative method of estimating the ground state degeneracies, we investigated some widely studied HP proteins and their H0P counterparts. Dramatic differences in ground state and thermodynamic properties have been observed, e.g. the estimation of ground state degeneracy for the 46mer is 460,000 for the HP version and only 20 for the H0P mapping. Similarly, the specific heat and structural properties: radius of gyration and etc. show more pronounced signals associated with folding. Supported by NSF.

  4. Direct Electrochemistry of Cytochrome bo Oxidase at a series of Gold Nanoparticles-Modified Electrodes.

    PubMed

    Melin, Frederic; Meyer, Thomas; Lankiang, Styven; Choi, Sylvia K; Gennis, Robert B; Blanck, Christian; Schmutz, Marc; Hellwig, Petra

    2013-01-01

    New membrane-protein based electrodes were prepared incorporating cytochrome bo(3) from E. coli and gold nanoparticles. Direct electron transfer between the electrode and the immobilized enzymes was achieved, resulting in an electrocatalytic activity in presence of O(2). The size of the gold nanoparticles was shown to be important and smaller particles were shown to reduce the overpotential of the process.

  5. Spectral and structural features of Lu1 - x RE x BO3 compounds

    NASA Astrophysics Data System (ADS)

    Shmurak, S. Z.; Kedrov, V. V.; Kiselev, A. P.; Fursova, T. N.; Shmyt'ko, I. M.

    2015-08-01

    The luminescence spectra, luminescence excitation spectra, IR absorption spectra, and crystal structure of orthoborates Lu1 - x RE x BO3 ( RE = Eu, Gd, Tb, Y, Dy) have been investigated. It has been found that the solid solution consisting of a LuBO3 orthoborate, which has two stable structural modifications (calcite and vaterite), and an REBO3 orthoborate, which has one structural modification (vaterite), crystallizes only in the vaterite structure when the concentration of a rare-earth ion substituting for lutetium exceeds 15-20 at %. The investigation of the photoluminescence spectra has demonstrated that, for rare-earth ions Lu3+, Eu3+, Y3+, and Gd3+ in the vaterite modification of Lu1 - x RE x BO3 orthoborates, there are at least two positions that are not equivalent in the symmetry of the local environment. It has been established that the maximum intensity of the luminescence of the vaterite modification of Lu1 - x Tb x BO3 compounds synthesized at 970°C, which is observed at a terbium concentration of 15 at %, is several times higher than the maximum intensity of the luminescence of the calcite modification.

  6. High-temperature heat capacity of YFe3(BO3)4

    NASA Astrophysics Data System (ADS)

    Denisov, V. M.; Denisova, L. T.; Gudim, I. A.; Temerov, V. L.; Volkov, N. V.; Patrin, G. S.; Chumilina, L. G.

    2014-02-01

    The molar heat capacity of YFe3(BO3)4 has been measured using differential scanning calorimetry in the temperature range 339-1086 K. It has been found that the dependence C p = f( T) exhibits an extremum at a temperature of 401 K due to the structural transition.

  7. Laboratory Findings Suggesting an Association Between BoHV-4 and Bovine Abortions in Southern Belgium.

    PubMed

    Delooz, L; Czaplicki, G; Houtain, J Y; Dal Pozzo, F; Saegerman, C

    2017-08-01

    Abortions cause heavy economic losses for the bovine sector. The use of a standardized panel of analyses covering a large spectrum of pathogens responsible of abortion in cattle allowed demonstrating the direct involvement of at least one pathogen in 57% of analysed abortions in the southern part of Belgium. This result suggests a margin of improvement in the diagnostic efficacy. In order to evaluate the interest to broaden the list of pathogens included in the panel of analyses, the implication of bovine herpesvirus 4 (BoHV-4) in abortion was assessed by two different studies. In the first study, coupled serology was performed after abortion on 714 dams to identify specific seroconversion against BoHV-4. The overall seroconversion in cows was 19.5%, with a higher frequency in primiparous compared to multiparous females. In addition, the type of breed (beef cattle) and the time period from the fourth quarter 2008 until the last quarter 2009 were significantly related to the seroconversion of cows. The second study investigated the virus ability to infect the foetus. In this study, 368 cases of bovine abortions were specifically tested for BoHV-4, using PCR on foetus tissues and ELISA on dam and foetus sera. The results showed a maternal seroprevalence of 64.7%, a foetal seroprevalence of 0.8% and a PCR prevalence in foetuses of 1.1%, demonstrating the ability of BoHV-4 to infect the foetus. © 2016 Blackwell Verlag GmbH.

  8. Thermodynamic study of gaseous CsBO2 by Knudsen effusion mass spectrometry

    NASA Astrophysics Data System (ADS)

    Nakajima, K.; Takai, T.; Furukawa, T.; Osaka, M.

    2017-08-01

    One of the main chemical forms of cesium in the gas phase during severe light-water reactor accidents is expected to be cesium metaborate, CsBO2, according to thermodynamic equilibrium calculations considering its reaction with boron. However, the accuracy of the thermodynamic data of the gaseous metaborate, CsBO2(g), has been judged as poor. Thus, Knudsen effusion mass spectrometric measurements of CsBO2 were carried out to obtain reliable thermodynamic data. The evaluated values of the standard enthalpy of formation of CsBO2(g), obtained by the 2nd and 3rd-law treatments, are -700.7 ± 10.7 kJ/mol and -697.0 ± 10.6 kJ/mol, respectively, and agree with each other within the experimental errors, which indicates that our data are reliable. Furthermore, it was found that the existing data of the Gibbs energy function and the standard enthalpy of formation agreed well with the values evaluated in this study, which indicates that the existing thermodynamic data are also reliable.

  9. Measurements of Faint and Wide Doubles in Boötes and Corona Borealis

    NASA Astrophysics Data System (ADS)

    Knapp, Wilfried; Thuemen, Chris

    2017-01-01

    Images of several double stars in Boötes and Corona Borealis published on the “Double Star Imaging Project” Yahoo Group page suggest magnitude issues compared with the corresponding WDS catalog data per Jan 2016. Taking additional images with V-filter enabled photometry and astrometry for these pairs as a counter-check.

  10. Nonlinear optical frequency conversion with KTP and BiBO crystals for lasers in space

    NASA Astrophysics Data System (ADS)

    Potreck, Arne; Schröder, Helmut; Lammers, Melanie; Tzeremes, Georgios; Riede, Wolfgang

    2014-09-01

    Within ESA's ADM-Aeolus and EarthCARE missions Doppler-wind Lidar systems will be operated in the Earth's orbit to measure global wind profiles. The active instrument will be based on a Nd:YAG laser, frequency tripled by nonlinear optical crystals. Different crystals are therefore to compare and qualify in regard of their space acceptability. A dedicated set-up to measure the maximum conversion efficiencies and its stability during longterm operation for KTP crystals (SHG) and BiBO crystals (SHG and THG) is presented in this work. In order to detect gray-tracking and its influence on thermal lensing in situ, measurements with a Shack-Hartmann sensor and a co-aligned HeNe laser were performed. Conversion efficiencies were 76+/-3 % at SHG for KTP and BiBO crystals and 48+/-2 % at THG with a combination of two BiBO crystals. During longterm experiments of 60 million laser pulses, conversion efficiencies were demonstrated to be stable over time (+/-1 % at SHG with KTP and +/-2 % at THG with BiBO). The occurrence of gray-tracking was detected in the KTP crystal and the resulting thermal lensing with an exponential saturation over time was observed in situ.

  11. Magnetism and charge order in the ladder compound Co3O2BO3

    NASA Astrophysics Data System (ADS)

    Freitas, D. C.; Medrano, C. P. C.; Sanchez, D. R.; Regueiro, M. Nuñez; Rodríguez-Velamazán, J. A.; Continentino, M. A.

    2016-11-01

    There are two known ludwigites containing a single transition metal element, Fe3O2BO3 and Co3O2BO3 . The structure of these materials has low-dimensional units in the form of three-legged ladders (3LL) that confer to each of them unique magnetic and electronic properties. Fe3O2BO3 presents a staggered charge density wave (CDW) transition in the ladders near room temperature and two magnetic transitions. It has remained a mystery why the other compound Co3O2BO3 behaves so conventionally, with a single magnetic transition and no CDW in spite of similar structural and electronic configurations. Neutron diffraction results presented here in this system finally unravel these differences. Far from a trivial explanation, we uncover a coexistence of low and high spin Co ions in well-defined octahedral sites. Our results allow one to solve the contrasting behavior of the Fe and Co ludwigites in terms of a subtle and unique charge ordering mechanism occurring at the microscopic level of the rungs of the 3LL.

  12. 46. Quincy, MA, BO37, Launch Area, Underground Missile Storage Structure, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Quincy, MA, BO-37, Launch Area, Underground Missile Storage Structure, interior view of elevator system with overhead doors in open position and hydraulic shaft in left foreground VIEW WEST - NIKE Missile Battery PR-79, Launch Area, East Windsor Road south of State Route 101, Foster, Providence County, RI

  13. Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis

    PubMed Central

    Sun, Steven; Ossandon, Miguel; Kostov, Yordan

    2010-01-01

    A Lab-on-a-chip (LOC) was designed, fabricated and tested for the in vitro detection of botulinum neurotoxin serotype A (BoNT-A) activity using an assay that measures cleavage of a fluorophore-tagged peptide substrate specific for BoNT-A (SNAP-25) by the toxin light chain (LcA). LcA cleavage was detected by Förster Resonance Energy Transfer (FRET) fluorescence. FRET fluorescence was measured by a newly developed portable charge-coupled device (CCD) fluorescent detector equipped with multi-wavelength light-emitting diodes (LED) illumination. An eight V-junction microchannel device for BoNTs activity assays was constructed using Laminated Object Manufacturing (LOM) technology. The six-layer device was fabricated with a Poly(methyl methacrylate (PMMA) core and five polycarbonate (PC) layers micromachined by CO2 laser. The LOC is operated by syringe and is equipped with reagents, sample wells, reaction wells, diffusion traps (to avoid cross contamination among channels) and waste reservoirs. The system was detected LcA at concentrations as low as 0.5 nM, which is the reported sensitivity of the SNAP-25 in vitro cleavage assay. Combined with our CCD detector, the simple point of care system enables the detection of BoNTs activity and may be useful for the performance of other complex medical assays without a laboratory. This approach may realize the potential to enhance the quality of health care delivery for underserved populations. PMID:19865736

  14. Synthesis and structural characterization of Li3K3Y7(BO3)9

    NASA Astrophysics Data System (ADS)

    Bräuchle, Sebastian; Huppertz, Hubert

    2017-09-01

    Li3K3Y7(BO3)9 was prepared by high-temperature solid state synthesis at 900 °C in a platinum crucible from lithium carbonate, potassium carbonate, boric acid, and yttrium(III) oxide. The compound crystallizes in the orthorhombic space group Pca21 (no. 29) (Z = 4). The structure was refined from single-crystal X-ray diffraction data: a = 20.743(8), b = 6.387(4), c = 17.474(4) Å, V = 2315.2(2) Å3, R1 = 0.0473, and wR2 = 0.0637 for all data. The crystal structure of Li3K3Y7(BO3)9 consists of isolated BO3 groups forming [Li3B4O21] units in combination with LiO6 octahedra in the ac plane, which are interconnected to each other by additional planar BO3 groups. The Y3+ and K+ cations are arranged in layers along the a-axis.

  15. Bridge No. 1601, Third B&O Crossing, over CSX tracks in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bridge No. 1601, Third B&O Crossing, over CSX tracks in North Branch, Maryland, looking northwest. The Pittsburgh Plate Glass Plant can be seen in the background. NPS property boundary is out of view at lower right. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  16. BoGEMMS: the Bologna Geant4 multi-mission simulator

    NASA Astrophysics Data System (ADS)

    Bulgarelli, A.; Fioretti, V.; Malaguti, P.; Trifoglio, M.; Gianotti, F.

    2012-07-01

    BoGEMMS, (Bologna Geant4 Multi-Mission Simulator) is a software project for fast simulation of payload on board of scientific satellites for prompt background evaluation that has been developed at the INAF/IASF Bologna. By exploiting the Geant4 set of libraries, BoGEMMS allows to interactively set the geometrical and physical parameters (e.g. physics list, materials and thicknesses), recording the interactions (e.g. energy deposit, position, interacting particle) in NASA FITS and CERN root format output files and filtering the output as a real observation in space, to finally produce the background detected count rate and spectra. Four different types of output can be produced by the BoGEMMS capturing different aspects of the interactions. The simulator can also run in parallel jobs and store the results in a centralized server via xrootd protocol. The BoGEMMS is a multi-mission tool, generally designed to be applied to any high-energy mission for which the shielding and instruments performances analysis is required.

  17. Molecular Cloning and Characterization of Babesia orientalis Rhoptry Neck 2 BoRON2 Protein

    PubMed Central

    Yu, Long; He, Pei; He, Junwei; Sun, Yali; Huang, Yuan

    2017-01-01

    Babesiosis caused by Babesia orientalis is one of the most prevalent infections of water buffalo transmitted by Rhipicephalus haemaphysaloides causing a parasitic and hemolytic disease. The organelles proteins localized in apical membrane especially rhoptries neck and microneme protein form a complex called moving junction important during invasion process of parasites belonging to apicomplexan group, including Babesia species. A truncated fragment coding a 936 bps fragment was cloned in pMD-19T and subcloned into pET32 (a)+ expression vector, expressed in E. coli BL21. Purified recombinant BoRON2 was used to produce polyclonal antibody against BoRON2. Here, we identified the full sequence of gene encoding the rhoptry neck 2 protein that we named BoRON2 which is 4035 bp in full-length open reading frame without introns, encoding a polypeptide of 1345 amino acids. Western blot of rBoRON2 probed with buffalo positive serum analysis revealed a band of around 150 kDa in parasite lysates, suggesting an active involvement during invasion process. These findings most likely are constructive in perspective of ongoing research focused particularly on water buffalo babesiosis prevention and therapeutics and globally provide new information for genes comparative analysis. PMID:28775897

  18. 40 CFR 721.1730 - Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1730 Section 721.1730 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1... acid (H3BO3) (PMN P-97-636; CAS No. 106008-93-9) is subject to reporting under this section for the...

  19. 40 CFR 721.1731 - Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1731 Section 721.1731 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1... acid (H3BO3) (PMN P-97-637; CAS No. 106008-94-0) is subject to reporting under this section for the...

  20. 40 CFR 721.1730 - Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1730 Section 721.1730 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1... acid (H3BO3) (PMN P-97-636; CAS No. 106008-93-9) is subject to reporting under this section for the...

  1. 40 CFR 721.1731 - Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1731 Section 721.1731 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1... acid (H3BO3) (PMN P-97-637; CAS No. 106008-94-0) is subject to reporting under this section for the...

  2. 40 CFR 721.1730 - Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1730 Section 721.1730 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1... acid (H3BO3) (PMN P-97-636; CAS No. 106008-93-9) is subject to reporting under this section for the...

  3. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Boric acid (H3BO3), mixed esters with... acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

  4. 40 CFR 721.1731 - Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1731 Section 721.1731 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1... acid (H3BO3) (PMN P-97-637; CAS No. 106008-94-0) is subject to reporting under this section for the...

  5. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Boric acid (H3BO3), mixed esters with... acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

  6. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Boric acid (H3BO3), mixed esters with... acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

  7. A triple gene mutant of BoHV-1 administered intranasally in lambs replicates efficiently in the nasal epithelium and induces neutralizing antibody

    USDA-ARS?s Scientific Manuscript database

    Bovine herpes virus 1 (BoHV-1) causes respiratory infections and abortions in cattle, and is an important component of Bovine respiratory disease complex (BRDC). BoHV-1 has also been isolated from sheep with respiratory disorder. Experimentally, sheep and goats are infected productively with BoHV-1...

  8. Elimination of Botulinum Neurotoxin (BoNT) Type B from Drinking Water by Small-Scale (Personal-Use) Water Purification Devices and Detection of BoNT in Water Samples

    PubMed Central

    Hörman, Ari; Nevas, Mari; Lindström, Miia; Hänninen, Marja-Liisa; Korkeala, Hannu

    2005-01-01

    Seven small-scale drinking water purification devices were evaluated for their capacity to eliminate botulinum neurotoxin (BoNT) type B from drinking water. Influent water inoculated with toxic Clostridium botulinum cultures and effluent purified water samples were tested for the presence of BoNT by using a standard mouse bioassay and two commercial rapid enzyme immunoassays (EIAs). The water purification devices based on filtration through ceramic or membrane filters with a pore size of 0.2 to 0.4 μm or irradiation from a low-pressure UV-lamp (254 nm) failed to remove BoNT from raw water (reduction of <0.1 log10 units). A single device based on reverse osmosis was capable of removing the BoNT to a level below the detection limit of the mouse bioassay (reduction of >2.3 log10 units). The rapid EIAs intended for the detection of BoNT from various types of samples failed to detect BoNT from aqueous samples containing an estimated concentration of BoNT of 396,000 ng/liter. PMID:15812023

  9. Elimination of botulinum neurotoxin (BoNT) type B from drinking water by small-scale (personal-use) water purification devices and detection of BoNT in water samples.

    PubMed

    Hörman, Ari; Nevas, Mari; Lindström, Miia; Hänninen, Marja-Liisa; Korkeala, Hannu

    2005-04-01

    Seven small-scale drinking water purification devices were evaluated for their capacity to eliminate botulinum neurotoxin (BoNT) type B from drinking water. Influent water inoculated with toxic Clostridium botulinum cultures and effluent purified water samples were tested for the presence of BoNT by using a standard mouse bioassay and two commercial rapid enzyme immunoassays (EIAs). The water purification devices based on filtration through ceramic or membrane filters with a pore size of 0.2 to 0.4 microm or irradiation from a low-pressure UV-lamp (254 nm) failed to remove BoNT from raw water (reduction of < 0.1 log10 units). A single device based on reverse osmosis was capable of removing the BoNT to a level below the detection limit of the mouse bioassay (reduction of > 2.3 log10 units). The rapid EIAs intended for the detection of BoNT from various types of samples failed to detect BoNT from aqueous samples containing an estimated concentration of BoNT of 396,000 ng/liter.

  10. Retraction.

    PubMed

    2014-04-01

    “Surgical Management of Cesarean Scar Ectopic Pregnancy with Totally Extraperitoneal Hysterotomy via Transvaginal Approach” by Ying-Han Chen, Dan-Bo Wang, Peng Chen and Fang Ren.The above article, published online on 23 January 2014 in Wiley Online Library as an accepted article (wileyonlinelibrary. com; doi/10.1111/aogs.12341/abstract), has been retracted by agreement between the authors, the journal Chief Editor, Professor Reynir Tomas Geirsson, and John Wiley & Sons Ltd. The retraction has been agreed due to prior publication of a substantially similar article in Fertility and Sterility (http://www.fertstert.org/article/S0015-0282(13)03170-1/abstract).

  11. The Use of TaBoRR as a Heavy Oil Upgrader

    SciTech Connect

    Lee Brecher; Charles Mones

    2009-02-05

    Preliminary testing has shown that Western Research Institute's (WRI) Tank Bottom Recovery and Remediation (TaBoRR{reg_sign}) technology shows promise for heavy oil upgrading. Approximately 70 to 75 wt% of a Canadian Cold Lake bitumen feed was converted to a partially upgraded overhead product that could be transported directly by pipeline or blended with the parent bitumen to produce transportable crude. TaBoRR{reg_sign} was originally developed to remediate tank bottom wastes by producing a distillate product and solid waste. TaBoRR{reg_sign}'s processing steps include breaking a water-oil emulsion, recovering a light hydrocarbon fraction by distillation in a stripper unit, and pyrolyzing the residua reducing it to additional overhead and a benign coke for disposal. Cold Lake bitumen was tested in WRI's bench-scale equipment to evaluate the potential use of TaBoRR{reg_sign} technology for heavy oil upgrading to produce a stable, partially (or fully) upgraded product that will allow diluent-reduced or diluent-free transportation of bitumen or ultra-heavy crudes to market. Runs were conducted at temperatures of low, intermediate and high severity in the stripper to produce stripper overhead and bottoms. The bottoms from each of these runs were processed further in a 6-inch screw pyrolyzer to produce pyrolyzer overhead for blending with the corresponding stripper overheads. Proceeding in this fashion yielded three partially upgraded crudes. The products from TaBoRR{reg_sign} processing, the parent bitumen, and bitumen blends were subjected to stability and compatibility testing at the National Centre for Upgrading Technology (NCUT). Chemical analyses of the overhead product blends have met pipeline specifications for viscosity and density; however the bromine number does not, which might indicate the need for mild hydrotreating. Storage stability tests showed the blends to be stable. The blends were also soluble and compatible with most other Alberta crudes.

  12. Convergence of Stochastic Approximation Monte Carlo and modified Wang-Landau algorithms: Tests for the Ising model

    NASA Astrophysics Data System (ADS)

    Schneider, Simon; Mueller, Marco; Janke, Wolfhard

    2017-07-01

    We investigate the behavior of the deviation of the estimator for the density of states (DOS) with respect to the exact solution in the course of Wang-Landau and Stochastic Approximation Monte Carlo (SAMC) simulations of the two-dimensional Ising model. We find that the deviation saturates in the Wang-Landau case. This can be cured by adjusting the refinement scheme. To this end, the 1 / t-modification of the Wang-Landau algorithm has been suggested. A similar choice of refinement scheme is employed in the SAMC algorithm. The convergence behavior of all three algorithms is examined. It turns out that the convergence of the SAMC algorithm is very sensitive to the onset of the refinement. Finally, the internal energy and specific heat of the Ising model are calculated from the SAMC DOS and compared to exact values.

  13. Phase equilibria of molecular fluids via hybrid Monte Carlo Wang-Landau simulations: applications to benzene and n-alkanes.

    PubMed

    Desgranges, Caroline; Delhommelle, Jerome

    2009-06-28

    In recent years, powerful and accurate methods, based on a Wang-Landau sampling, have been developed to determine phase equilibria. However, while these methods have been extensively applied to study the phase behavior of model fluids, they have yet to be applied to molecular systems. In this work, we show how, by combining hybrid Monte Carlo simulations in the isothermal-isobaric ensemble with the Wang-Landau sampling method, we determine the vapor-liquid equilibria of various molecular fluids. More specifically, we present results obtained on rigid molecules, such as benzene, as well as on flexible chains of n-alkanes. The reliability of the method introduced in this work is assessed by demonstrating that our results are in excellent agreement with the results obtained in previous work on simple fluids, using either transition matrix or conventional Monte Carlo simulations with a Wang-Landau sampling, and on molecular fluids, using histogram reweighting or Gibbs ensemble Monte Carlo simulations.

  14. Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity.

    PubMed

    Ouimet, Tanja; Duquesnoy, Sophie; Poras, Hervé; Fournié-Zaluski, Marie-Claude; Roques, Bernard P

    2013-07-01

    Detection and quantification of low doses of botulinum toxin serotype A (BoNT/A) in medicinal preparations require precise and sensitive methods. With mounting pressure from governmental authorities to replace the mouse LD50 assay, interest in alternative methods such as the endopeptidase assay, quantifying the toxin active moiety, is growing. Using internal collision-induced fluorescence quenching, Pharmaleads produced peptides encompassing the SNAP-25 cleavage site: a 17-mer (PL63) and a 48-mer (PL50) reaching the previously identified α-exosite, with PL50 showing higher apparent affinity for BoNT/A. Peptide mapping experiments revealed that this increased affinity is mainly due to a connecting peptide sequence between the N-terminus of PL63 and the α-exosite, identifying a new cooperative exosite on BoNT/A. Other endopeptidase substrates available, including SNAPTide and BoTest A/E, are both based on fluorescent resonance energy transfer (FRET) technology. To compare these assays, their limits of detection and quantification were determined using light chain or 150-kDa BoNT/A. Detection limits of PL50 and BoTest were over 100 times better than those using SNAPtide in standard conditions. Although the BoTest possessed a detection limit around 0.2 pM for either BoNT/A form, its quantification limit (9.7 pM) using purified BoNT/A was 12 times inferior to PL50, estimated at 0.8 pM, suitable for medicinal preparation quantification.

  15. Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review.

    PubMed

    Wang, Ting; Guo, Rixin; Zhou, Guohong; Zhou, Xidan; Kou, Zhenzhen; Sui, Feng; Li, Chun; Tang, Liying; Wang, Zhuju

    2016-07-21

    Panax notoginseng (Burk.) F.H. Chen is a widely used traditional Chinese medicine known as Sanqi or Tianqi in China. This plant, which is distributed primarily in the southwest of China, has wide-ranging pharmacological effects and can be used to treat cardiovascular diseases, pain, inflammation and trauma as well as internal and external bleeding due to injury. This paper provides up-to-date information on investigations of this plant, including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology. The possible uses and perspectives for future investigation of this plant are also discussed. The relevant information on Panax notoginseng (Burk.) F.H. Chen was collected from numerous resources, including classic books about Chinese herbal medicine, and scientific databases, including Pubmed, SciFinder, ACS, Ebsco, Elsevier, Taylor, Wiley and CNKI. More than 200 chemical compounds have been isolated from Panax notoginseng (Burk.) F.H. Chen, including saponins, flavonoids and cyclopeptides. The plant has pharmacological effects on the cardiovascular system, immune system as well as anti-inflammatory, anti-atherosclerotic, haemostatic and anti-tumour activities, etc. Panax notoginseng is a valuable traditional Chinese medical herb with multiple pharmacological effects. This review summarizes the botany, ethnopharmacology, phytochemistry, pharmacology and toxicology of P. notoginseng, and presents the constituents and their corresponding chemical structures found in P. notoginseng comprehensively for the first time. Future research into its phytochemistry of bio-active components should be performed by using bioactivity-guided isolation strategies. Further work on elucidation of the structure-function relationship among saponins, understanding of multi-target network pharmacology of P. notoginseng, as well as developing its new clinical usage and comprehensive utilize will enhance the therapeutic potentials of P. notoginseng. Copyright © 2016

  16. Antiferromagnetically Coupled Dimeric Dodecacopper Supramolecular Architectures of Macrocyclic Ligands with a Symmetrical μ6-BO3(3-) Central Moiety.

    PubMed

    Tandon, Santokh S; Bunge, Scott D; Toth, Sara A; Sanchiz, Joaquin; Thompson, Laurence K; Shelley, Jacob T

    2015-07-20

    Reactions between 2,6-diformyl-4-alkyl(R)-phenol (R = CH3 or C(CH3)3) and 1,3-diamino-2-hydroxypropane (1,3-DAP) in the presence of copper(II) salts (Cu(BF4)2·6H2O, Cu(ClO4)2·6H2O/H3BO3/Ar) and triethylamine (TEA) in a single pot result in self-assembly of dimeric dodecacopper supramolecular architectures of 30-membered hexatopic macrocyclic ligands (H6L4 and H6L5) with unique and fascinating structures having the BO3(3-) anion as the central species bonded to all six copper centers in a symmetrical fashion (μ6-BO3(3-)). A number of closely related macrocyclic hexacopper complexes are reported: {[Cu6(L4)(μ6-BO3)(μ-H2O)(C3H7NO)2(BF4)][BF4]2·3C3H7NO}2 (1) (DMF = C3H7NO), {[Cu6(L4)(μ6-BO3)(μ-C3H7NO)3][ClO4]3·3C3H7NO}2 (2), {[Cu6(L5)(μ6-BO3)(μ-OH)(H2O)3(C3H7NO)][BF4]2·6C3H7NO·4C2H5OH·2H2O}2 (3), {[Cu6(L5)(μ6-BO3)(μ-CH3OH)(CH3OH)2][ClO4]3·10H2O}2 (4), and {[Cu6(L5)(μ6-BO3)(μ-CH3CO2)(μ-CH3O)(CH3OH)][BF4]·13CH3OH·8H2O}2 (5). A polymeric side product {[Cu2(H2L2)(CH3OH)(BF4)][BF4]}n (6), involving a 2 + 2 macrocyclic ligand, was also isolated and structurally characterized. Complex 6 involves dinuclear copper(II) units linked through BF4(-) anions to form a novel 1D single-chain polymeric coordination compound. This appears to be the first report in which a central BO3(3-) species is linked to six copper(II) ions held together by a single macrocyclic ligand through three μ1,1-O(BO3(3-)) and three μ1,3-O(BO3(3-)) bridges. In complexes 1-5 the BO3(3-) is present in the center of the macrocyclic cavity and is bonded to all six metal centers arranged in a benzene-like hexagonal array. In the hexagonal array there are alternate double (μ-alkoxide and μ1,3-O(BO3(3-))) and (μ-phenoxide and μ1,1-O(BO3(3-))) bridges between the Cu(II) centers. The symmetrical hexa-bridging nature of μ6-BO3(3-) is unprecedented in transition metal complex chemistry, and along with alkoxide and phenoxide bridges in the equatorial plane provides effective pathways for an

  17. Uca cryptica Naderloo, Türkay & Chen, 2010 (Crustacea: Brachyura:
    Ocypodidae) is no longer cryptic.

    PubMed

    Michie, Laura A; Cragg, Simon M; Barnes, R S K; Bennett, Wayne A

    2015-07-03

    Uca cryptica Naderloo, Türkay & Chen, 2010, was originally described from four male specimens found in museum collections without any information regarding the site of collection. We present the first recorded field observations of this species and new morphological features. Specimens were observed and collected in the Wakatobi National Park, on the island of Kaledupa, Sulawesi Tenggara, Indonesia. Colouration of both males and females is described and ecology and distribution are noted. Uca cryptica has been seen coexisting with nine other species; one of the highest recorded numbers of Uca species living in sympatry.

  18. Chemosynthesis pathway and bioactivities comparison of saponins in radix and flower of Panax notoginseng (Burk.) F.H. Chen.

    PubMed

    Zhou, Xin; Chen, Lin-Lin; Xie, Rui Fang; Lam, Wing; Zhang, Zi-Jia; Jiang, Zao-Li; Cheng, Yung-Chi

    2017-04-06

    Panax notoginseng (Burk.) F.H. Chen is a well known medicinal plant. Its radix is used in the history while its flower is recently used for health care. In this study we compared chemical ingredients and bioactivities in cell culture for radix and flower of Panax notoginseng (Burk.) F.H. Chen. The liquid chromatography-mass spectrometry system was applied to determine the contents of saponins in flower and radix of Panax notoginseng (Burk.) F.H. Chen. Transcription specific luciferase reporter assay and qPCR method for selected RNA were carried out to assess the impacts of flower and radix extract on the transcription signal pathways. The results of chemical analysis showed that the contents of saponins in flower and radix are very different: the contents of Rg1, Rb1, Re, R1, Rg3-20R, Rh1 and Rf in radix are abundant; in contrast, the contents of Rb3, Fc, Ft1, Rb2 and Rh2-20s in flowers are plentiful. There are substantial variations of those saponin contents from one batch vs another. Based on relative content of saponins, the chemosynthesis pathway of ingredients in radix and flower are proposed: for radix, both PPT (Protopanaxatriol) and PPD (Protopanaxadiol) type triterpenoids are involved, the main pathway is PPT→Rb1→Rg1→R1 or PPD→Rh2 20s→Rg3(20s)→Rd→Rb1; for flowers, only PPD is main passage with PPD→Rh2 (20s)→Rg3(20s)→Rd→Rb2→Fc. The results of signal transcription assays demonstrated that herb water extract of radix and flower had no significant influences on most of transcription activities. However, total saponins of radix and flower which have highly content of saponins were able to inhibit the inflammatory related transcriptional activities and their related mRNA expression of IFNα, TNFα, il-6 and TGFβ as well as induce anti-oxygen NrF2 activities. In summary, although chemical ingredients and chemosynthesis pathway of flower and radix for Panax notoginseng (Burk.) F.H. Chen were different, these differences might not result in

  19. Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367.

    PubMed

    Yoshinari, T; Mano, E; Arakawa, H; Kurama, M; Iguchi, T; Nakagawa, S; Tanaka, N; Okura, A

    1993-07-01

    A new antimicrobial quinolone (-)BO-2367, (-)-7-[(1R*, 2R*, 6R*)-2-amino-8-azabicyclo[4.3.0.]-non-3-en-8-yl]-1- cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, strongly inhibited both mammalian and bacterial topoisomerase II. The IC50 values of (-)BO-2367 against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase were 3.8, 0.5, and 1 microM, respectively. This compound enhanced double-stranded DNA cleavage mediated by topoisomerase II not only with purified enzyme, but also with intact L1210 cells. All these activities of (-)BO-2367 were more than 2-fold stronger than those of VP-16. Intriguingly, (+)BO-2367, which has an enantiomeric substituent at the C7 position of (-)BO-2367, did not affect the activity of the mammalian topoisomerase II, while it inhibited E. coli gyrase. Intraperitoneal injection of (-)BO-2367 at 0.08 mg/kg increased the lifespan of CDF1 female mice bearing ascitic L1210 leukemia by 2.4 times, and subcutaneous injection at 1.25 mg/kg completely inhibited the growth of colon 26 carcinoma implanted subcutaneously. These results suggest that (-)BO-2367 is a potent antitumor agent which targets topoisomerase II. These enantiomers should be a useful tool for studying drug-topoisomerase II interactions.

  20. Improved Electrochemical Performance of Carbon-Coated LiFeBO3 Nanoparticles for Lithium-Ion Batteries

    SciTech Connect

    Li, Zhaoping; Wang, Yiping; Hu, Querui; Yang, Ying; Wu, Zhuangchun; Ban, Chunmei

    2015-09-01

    Carbon-coated LiFeBO3 nanoparticles have been successfully prepared by surfactant-assisted ball milling and a size selection process based on centrifugal separation. We observed monodispersed LiFeBO3 nanoparticles with dimensions of 10–20 nm by transmission electron microscope. The introduced surfactant acts as the dispersant as well as the carbon source for LiFeBO3 nanoparticles. Greatly improved discharge capacities of 190.4 mA h g–1 at 0.1 C and 106.6 mA h g–1 at 1 C rate have been achieved in the LiFeBO3 nanoparticles when cycling the cells between 1.0 V and 4.8 V. Meanwhile, the as-prepared micro-size LiFeBO3 electrodes show lower discharge capacities of 142 mA h g–1 and 93.3 mA h g–1 at 0.1 C and 1 C rates. Moreover, the post-treated LiFeBO3 nanostructure has drastically enhanced the electrochemical performance due to the short diffusion length and ameliorated electrical contract between LiFeBO3 nano particles.

  1. Expression, purification and transduction of PEP-1-botulinum neurotoxin type A (PEP-1-BoNT/A) into skin.

    PubMed

    Kim, Dae Won; Kim, So Young; An, Jae Jin; Lee, Sun Hwa; Jang, Sang Ho; Won, Moo Ho; Kang, Tae Cheon; Chung, Kwang-Hoe; Jung, Hyun-Ho; Cho, Sung-Woo; Choi, Jin Hi; Park, Jinseu; Eum, Won Sik; Choi, Soo Young

    2006-09-30

    Botulinum neurotoxin A (BoNT/A) has been used therapeutically to treat muscular hypercontractions and sudomotor hyperactivity and it has been reported that BoNT/A might have analgesic properties in headache. PEP-1 peptide is a known carrier peptide that delivers full-length native proteins in vitro and in vivo. In this study, a BoNT/A gene were fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-BoNT/A fusion protein. The expressed and purified PEP-1-BoNT/A fusion proteins were efficiently transduced into cells in a time- and dose-dependent manner when added exogenously in a culture medium. In addition, immunohistochemical analysis revealed that PEP-1-BoNT/A fusion protein efficiently penetrated into the epidermis as well as the dermis of the subcutaneous layer, when sprayed on mice skin. These results suggest that PEP-1-BoNT/A fusion protein provide an efficient strategy for therapeutic delivery in various human diseases related to this protein.

  2. Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows.

    PubMed

    Kulberg, S; Heringstad, B; Guttersrud, O A; Olsaker, I

    2007-08-01

    Genotyping of bovine leucocyte antigen DRB3.2 (BoLA-DRB3.2) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA-DRB3.2 alleles across the groups. Significant differences in BoLA-DRB3.2 allele frequencies were found between the selection groups. Alleles *13, *18, *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3, *9, *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA-DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741,072 first-lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7, *11, *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA-DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes.

  3. BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models

    PubMed Central

    Ambati, Srikanth R.; Shieh, Jae-Hung; Pera, Benet; Lopes, Eloisi Caldas; Chaudhry, Anisha; Wong, Elissa W.P.; Saxena, Ashish; Su, Tsann-Long; Moore, Malcolm A.S.

    2016-01-01

    DNA damaging agents cause rapid shrinkage of tumors and form the basis of chemotherapy for sarcomas despite significant toxicities. Drugs having superior efficacy and wider therapeutic windows are needed to improve patient outcomes. We used cell proliferation and apoptosis assays in sarcoma cell lines and benign cells; γ-H2AX expression, comet assay, immunoblot analyses and drug combination studies in vitro and in patient derived xenograft (PDX) models. BO-1055 caused apoptosis and cell death in a concentration and time dependent manner in sarcoma cell lines. BO-1055 had potent activity (submicromolar IC50) against Ewing sarcoma and rhabdomyosarcoma, intermediate activity in DSRCT (IC50 = 2-3μM) and very weak activity in osteosarcoma (IC50 >10μM) cell lines. BO-1055 exhibited a wide therapeutic window compared to other DNA damaging drugs. BO-1055 induced more DNA double strand breaks and γH2AX expression in cancer cells compared to benign cells. BO-1055 showed inhibition of tumor growth in A673 xenografts and caused tumor regression in cyclophosphamide resistant patient-derived Ewing sarcoma xenografts and A204 xenografts. Combination of BO-1055 and irinotecan demonstrated synergism in Ewing sarcoma PDX models. Potent activity on sarcoma cells and its relative lack of toxicity presents a strong rationale for further development of BO-1055 as a therapeutic agent. PMID:27248664

  4. Controlled synthesis of different multilayer architectures of GdBO3:Eu3+ phosphors and shape-dependent luminescence properties

    NASA Astrophysics Data System (ADS)

    Leng, Zhihua; Zhang, Nannan; Liu, Yali; Li, Linlin; Gan, Shucai

    2015-03-01

    Monodisperse pancake-like/flower-like/leaf-like GdBO3 samples have been successfully synthesized via a designed hydrothermal conversion method using H3BO3, Na2B4O7·10H2O, or NaBO2·4H2O as boron sources, respectively. It was found that different boron sources have crucial influences on the formation and morphology of the products. The Gd(OH)3 nanorods precursors were prepared through a simple hydrothermal process, which then served as sacrificial templates for the fabrication of GdBO3 micropancakes/microflowers/microleaves via a hydrothermal conversion process. FT-IR spectra confirm that vaterite-type GdBO3 can be synthesized by this method. The possible formation mechanisms for different microstructures were put forward on the basis of a series of time-dependent control experiments. The products have similar stacked arrangements driven by the minimization of the interfacial and surface energy of the hydrothermal system. An investigation on the photoluminescence (PL) properties of GdBO3:Eu3+ samples with different morphologies indicates that the PL properties of as-obtained GdBO3:Eu3+ phosphors are strongly dependent on their morphology and crystallinity. The flower-like structure exhibits the strongest red emission.

  5. Performance of Replica-Exchange Wang-Landau Sampling for the 2D Ising Model: A Brief Survey

    SciTech Connect

    Zhao, Yiwei; Cheung, Siu Wun; Li, Ying Wai; Eisenbach, Markus

    2014-01-01

    We report a brief performance study of the replica-exchange Wang-Landau algorithm, a recently proposed parallel realization of Wang-Landau sampling, using the 2D Ising model as a test case. The simulation time is found to scale inversely with the square root of the number of subwindows (and thus number of processors) used to span the global parameter space. We also investigate the time profiles for random walkers in dierent subwindows to complete iterations, which will aid the development of and adaptive load-balancing scheme.

  6. Structures of delithiated and degraded LiFeBO(3), and their distinct changes upon electrochemical cycling.

    PubMed

    Bo, Shou-Hang; Nam, Kyung-Wan; Borkiewicz, Olaf J; Hu, Yan-Yan; Yang, Xiao-Qing; Chupas, Peter J; Chapman, Karena W; Wu, Lijun; Zhang, Lihua; Wang, Feng; Grey, Clare P; Khalifah, Peter G

    2014-07-07

    Lithium iron borate (LiFeBO3) has a high theoretical specific capacity (220 mAh/g), which is competitive with leading cathode candidates for next-generation lithium-ion batteries. However, a major factor making it difficult to fully access this capacity is a competing oxidative process that leads to degradation of the LiFeBO3 structure. The pristine, delithiated, and degraded phases of LiFeBO3 share a common framework with a cell volume that varies by less than 2%, making it difficult to resolve the nature of the delithiation and degradation mechanisms by conventional X-ray powder diffraction studies. A comprehensive study of the structural evolution of LiFeBO3 during (de)lithiation and degradation was therefore carried out using a wide array of bulk and local structural characterization techniques, both in situ and ex situ, with complementary electrochemical studies. Delithiation of LiFeBO3 starts with the production of LitFeBO3 (t ≈ 0.5) through a two-phase reaction, and the subsequent delithiation of this phase to form Lit-xFeBO3 (x < 0.5). However, the large overpotential needed to drive the initial two-phase delithiation reaction results in the simultaneous observation of further delithiated solid-solution products of Lit-xFeBO3 under normal conditions of electrochemical cycling. The degradation of LiFeBO3 also results in oxidation to produce a Li-deficient phase D-LidFeBO3 (d ≈ 0.5, based on the observed Fe valence of ∼2.5+). However, it is shown through synchrotron X-ray diffraction, neutron diffraction, and high-resolution transmission electron microscopy studies that the degradation process results in an irreversible disordering of Fe onto the Li site, resulting in the formation of a distinct degraded phase, which cannot be electrochemically converted back to LiFeBO3 at room temperature. The Li-containing degraded phase cannot be fully delithiated, but it can reversibly cycle Li (D-Lid+yFeBO3) at a thermodynamic potential of ∼1.8 V that is

  7. Entropy of diluted antiferromagnetic Ising models on frustrated lattices using the Wang-Landau method.

    PubMed

    Shevchenko, Yuriy; Nefedev, Konstantin; Okabe, Yutaka

    2017-05-01

    We use a Monte Carlo simulation to study the diluted antiferromagnetic Ising model on frustrated lattices including the pyrochlore lattice to show the dilution effects. Using the Wang-Landau algorithm, which directly calculates the energy density of states, we accurately calculate the entropy of the system. We discuss the nonmonotonic dilution concentration dependence of residual entropy for the antiferromagnetic Ising model on the pyrochlore lattice, and compare it to the generalized Pauling approximation proposed by Ke et al. [Phys. Rev. Lett. 99, 137203 (2007)PRLTAO0031-900710.1103/PhysRevLett.99.137203]. We also investigate other frustrated systems, the antiferromagnetic Ising model on the triangular lattice and the kagome lattice, demonstrating the difference in the dilution effects between the system on the pyrochlore lattice and that on other frustrated lattices.

  8. Thermodynamics and structural properties of a confined HP protein determined by Wang-Landau simulation

    SciTech Connect

    Pattanasiri, Busara; Li, Ying Wai; Landau, David P; Wuest, Thomas; Triampo, Wannapong

    2013-01-01

    We used Wang-Landau sampling with inventive Monte Carlo moves to study the influence of surface characteristics on physical behavior of a hydrophobic-polar (HP) lattice protein model confined between two attractive surfaces. Three types of surfaces, namely, surfaces that attract: (a) all monomers; (b) only P monomers; or (c) only H monomers, have been considered. After obtaining the densities of states, we then found the thermodynamic and structural quantities, such as specific heat, number of surface contacts, and number of hydrophobic interaction pairs. A few conformational transitions , e.g., debridging process and hydrophobic core formation, can be identified based on an analysis of these quantities. Depending on the surface types, these transitions take place at different temperatures, while the ground state configurations show structural variations. These scenarios are confirmed by snapshots of typical states of the systems.

  9. OpenACC programs of the Swendsen-Wang multi-cluster spin flip algorithm

    NASA Astrophysics Data System (ADS)

    Komura, Yukihiro

    2015-12-01

    We present sample OpenACC programs of the Swendsen-Wang multi-cluster spin flip algorithm. OpenACC is a directive-based programming model for accelerators without requiring modification to the underlying CPU code itself. In this paper, we deal with the classical spin models as with the sample CUDA programs (Komura and Okabe, 2014), that is, two-dimensional (2D) Ising model, three-dimensional (3D) Ising model, 2D Potts model, 3D Potts model, 2D XY model and 3D XY model. We explain the details of sample OpenACC programs and compare the performance of the present OpenACC implementations with that of the CUDA implementations for the 2D and 3D Ising models and the 2D and 3D XY models.

  10. Five New C19 -Diterpenoid Alkaloids from Delphinium tianshanicum W.T.Wang.

    PubMed

    Zhang, Ji-Fa; Shan, Lian-Hai; Gao, Feng; Huang, Shuai; Zhou, Xian-Li

    2017-04-01

    Five new diterpenoid alkaloids, tianshanitines A-E (1 - 5), along with ten known compounds (6 - 15), were isolated from the EtOH extracts of the whole plant of Delphinium tianshanicum W.T.Wang. Their structures were determined based on extensive spectroscopic analyses, including 1D- and 2D-NMR, HR-ESI-MS, and the structure of tianshanitine C (3) was confirmed by X-ray diffraction analysis. Tianshanitine A (1) is the first example of natural diterpenoid alkaloid containing a benzoyl group at C(1) position. Tianshanitine B (2) is a rare natural diterpenoid alkaloid bearing a OH group at C(16) position. Compounds 1 - 5, 6, 8, 10, 12 and 14 were evaluated for cytotoxicity against HCT116, MCF-7 and HepG2 human cancer cell lines. © 2017 Wiley-VHCA AG, Zurich, Switzerland.

  11. Protective Effect of Tang Wang One Decoction on the Retinal Vessels of Diabetic Rats

    PubMed Central

    Kou, Xinyun; Yang, Shufei; Qin, Yali; Yang, Chao; Deng, Tingting; Luo, Dan

    2017-01-01

    Objective. This study aimed to determine the influence of Tang Wang One Decoction (TWOD) on the retinal vessels of diabetic rats. Methods. The hemorheology of diabetic rats was observed. Morphological studies of retinal vessels were conducted using optical microscopy and electron microscopy. Immunological histochemistry assay was used to measure the expression levels of MMP-9, occludin, and claudin-5. Results. Obvious pathological damage was observed in the retinal vessels of diabetic rats. TWOD positively affected the hemorheology and morphology of retinal vessels. The decoction also decreased the expression of MMP-9 and increased the expression of occludin and claudin-5. Conclusions. The results suggest that the retinal protective effects of TWOD might be related to downregulation of MMP-9 and upregulation of occludin and claudin-5. PMID:28367226

  12. [RAPD and SCAR molecular markers linked to the sexuality of cycads (Cycas tanqingii D. Y. Wang)].

    PubMed

    Jing, Jian-Zhou; Jin, Hong; Li, Dong-Liang; Chen, Xiao-Ke; Zhang, Yong

    2007-11-01

    The random amplified polymorphic DNA (RAPD) technique was used to amplify DNA fragment, aiming at finding markers linked to the sex trait in Cycas tanqingii D. Y. Wang. A total number of 160 random primers were screened in the RAPD-PCR and more than 2500 RAPD fragments were generated from the male or the female plants. One fragment of about 500 bp was amplified steadily and repeatedly by the S0465 (CCCCGGTAAC) primer only from female plants but not male plants. The RAPD marker was then converted into female-linked dominant SCAR (Sequence Characterized Amplified Regions) marker named STQC-S465-483. The development of this sex-linked SCAR marker provides a possibility of identifying the sex of Cycas tanqingii before sexual maturation, which is very important to in situ or ex situ conservation.

  13. Structural properties and thermodynamics of water clusters: a Wang-Landau study.

    PubMed

    Yin, Junqi; Landau, D P

    2011-02-21

    The temperature dependence of structural properties and thermodynamic behavior of water clusters has been studied using Wang-Landau sampling. Four potential models, simple point charge/extended (SPC/E), transferable intermolecular potential 3 point (TIP3P), transferable intermolecular potential 4 point (TIP4P), and Gaussian charge polarizable (GCP), are compared for ground states and properties at finite temperatures. Although the hydrogen bond energy and the distance of the nearest-neighbor oxygen pair are significantly different for TIP4P and GCP models, they approach to similar ground state structures and melting transition temperatures in cluster sizes we considered. Comparing with TIP3P, SPC/E model provides properties closer to that of TIP4P and GCP.

  14. Collapse transitions in a flexible homopolymer chain: application of the Wang-Landau algorithm.

    PubMed

    Seaton, D T; Wüst, T; Landau, D P

    2010-01-01

    The thermodynamic behavior of a continuous homopolymer is described using the Wang-Landau algorithm for chain lengths up to N=561. The coil-globule and liquid-solid transitions are analyzed in detail with traditional thermodynamic and structural quantities. The behavior of the coil-globule transition is well within theoretical and computational predictions for all chain lengths, while the behavior of the liquid-solid transition is much more susceptible to finite-size effects. Certain "magic number" lengths (N=13,55,147,309,561) , whose minimal energy states offer unique icosahedral geometries, are discussed along with chains residing between these special cases. The low temperature behavior near the liquid-solid transition is rich in structural transformations for certain chain lengths, showing many similarities to the behavior of classical clusters with similar interaction potentials. General comments are made on this size dependent behavior and how it affects transition behavior in this model.

  15. Characterizing folding funnels with replica exchange Wang-Landau simulation of lattice proteins.

    PubMed

    Shi, Guangjie; Wüst, Thomas; Landau, David P

    2016-11-01

    We have studied the folding of ribonuclease A by mapping it onto coarse-grained lattice protein models. With replica exchange Wang-Landau sampling, we calculated the free energy vs end-to-end distance as a function of temperature. A mapping to the famous hydrophobic-polar (HP) model shows a relatively shallow folding funnel and flat free energy minimum, reflecting the high degeneracy of the ground state. In contrast, extending the HP model with an additional "neutral" monomer type (i.e., a mapping to the three-letter H0P model) has a well developed, rough free energy funnel with a low degeneracy ground state. In both cases, folding funnels are asymmetric with temperature dependent shape.

  16. Replica-exchange Wang-Landau simulations of the H0P lattice protein model

    NASA Astrophysics Data System (ADS)

    Shi, Guangjie; Wüst, Thomas; Li, Ying Wai; Landau, David P.

    The hydrophobic-polar (HP) lattice protein model has been the subject of intensive investigation in an effort to aid our understanding of protein folding. However, the high ground state degeneracies caused by its simplification stands in contrast to the generally unique native states of natural proteins. Here we proposed a simple modification, by introducing a new type of ``neutral'' monomer, 0, i.e. neither hydrophobic nor polar, thus rendering the model more realistic without increasing the difficulties of sampling significantly. With the replica exchange Wang-Landau (REWL) scheme we investigated several widely studied HP proteins and their H0P counterparts. Dramatic differences in both ground state and thermodynamic properties have been found. For example, the H0P version of Crambin shows more clear two-step folding and 3 order of magnitudes less ground state degeneracy than its HP counterpart. Supported by NSF.

  17. Collapse transitions in a flexible homopolymer chain: Application of the Wang-Landau algorithm

    NASA Astrophysics Data System (ADS)

    Seaton, D. T.; Wüst, T.; Landau, D. P.

    2010-01-01

    The thermodynamic behavior of a continuous homopolymer is described using the Wang-Landau algorithm for chain lengths up to N=561 . The coil-globule and liquid-solid transitions are analyzed in detail with traditional thermodynamic and structural quantities. The behavior of the coil-globule transition is well within theoretical and computational predictions for all chain lengths, while the behavior of the liquid-solid transition is much more susceptible to finite-size effects. Certain “magic number” lengths (N=13,55,147,309,561) , whose minimal energy states offer unique icosahedral geometries, are discussed along with chains residing between these special cases. The low temperature behavior near the liquid-solid transition is rich in structural transformations for certain chain lengths, showing many similarities to the behavior of classical clusters with similar interaction potentials. General comments are made on this size dependent behavior and how it affects transition behavior in this model.

  18. Structural properties and thermodynamics of water clusters: A Wang-Landau study

    NASA Astrophysics Data System (ADS)

    Yin, Junqi; Landau, D. P.

    2011-02-01

    The temperature dependence of structural properties and thermodynamic behavior of water clusters has been studied using Wang-Landau sampling. Four potential models, simple point charge/extended (SPC/E), transferable intermolecular potential 3 point (TIP3P), transferable intermolecular potential 4 point (TIP4P), and Gaussian charge polarizable (GCP), are compared for ground states and properties at finite temperatures. Although the hydrogen bond energy and the distance of the nearest-neighbor oxygen pair are significantly different for TIP4P and GCP models, they approach to similar ground state structures and melting transition temperatures in cluster sizes we considered. Comparing with TIP3P, SPC/E model provides properties closer to that of TIP4P and GCP.

  19. Characterizing folding funnels with replica exchange Wang-Landau simulation of lattice proteins

    NASA Astrophysics Data System (ADS)

    Shi, Guangjie; Wüst, Thomas; Landau, David P.

    2016-11-01

    We have studied the folding of ribonuclease A by mapping it onto coarse-grained lattice protein models. With replica exchange Wang-Landau sampling, we calculated the free energy vs end-to-end distance as a function of temperature. A mapping to the famous hydrophobic-polar (HP) model shows a relatively shallow folding funnel and flat free energy minimum, reflecting the high degeneracy of the ground state. In contrast, extending the HP model with an additional "neutral" monomer type (i.e., a mapping to the three-letter H0P model) has a well developed, rough free energy funnel with a low degeneracy ground state. In both cases, folding funnels are asymmetric with temperature dependent shape.

  20. Surface adsorption of lattice HP proteins: Thermodynamics and structural transitions using Wang-Landau sampling

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Wüst, Thomas; Landau, David P.

    2012-12-01

    Wang-Landau sampling has been applied to investigate the thermodynamics and structural properties of a lattice hydrophobic-polar heteropolymer (the HP protein model) interacting with an attractive substrate. For simplicity, we consider a short HP sequence consisting of only 36 monomers interacting with a substrate which attracts all monomers in the sequence. The conformational “phase transitions” have been identified by a canonical analysis of the specific heat and suitable structural observables. Three major “transitions”, namely, adsorption, hydrophobic core formation and “flattening” of adsorbed structures, are observed. Depending on the surface attractive strength relative to the intra-protein attraction among the H monomers, these processes take place in different sequences upon cooling.

  1. Wang-Landau sampling of protein adsorption using the HP model

    NASA Astrophysics Data System (ADS)

    Li, Ying-Wai; Landau, D. P.; Wuest, T.

    2011-03-01

    We have applied Wang-Landau sampling with appropriate trial moves to investigate the thermodynamics and structural properties of lattice hydrophobic-polar heteropolymers (commonly known as the HP protein model) interacting with an attractive substrate. We estimate the density of states of the system, from which the partition function and all thermodynamic quantities, e.g. specific heat, radius of gyration, end-to-end distance and surface contacts, can be calculated. ``Transitions'' between ``phases'' are then identified based on a comprehensive analysis of these observables. Generally speaking, three transition processes are observed: adsorption-desorption, collapse (formation of hydrophobic core), and ``flattening'' of adsorbed structures. These have been confirmed by ``snapshots'' of typical states of the system. Depending on the surface attractive strength, these transitions take place in different order upon cooling, giving rise to different thermodynamic behaviors. Such dependence of folding hierarchy on the surface attraction is found to be universal for different HP sequences. Research supported by NSF.

  2. First principles finite temperature magnetism of defects in Fe using Wang-Landau method

    NASA Astrophysics Data System (ADS)

    Rusanu, Aurelian; Nicholson, D. M.; Odbadrakh, Kh.; Brown, Gregory; Eisenbach, Markus

    2011-03-01

    Magnetic structure of materials with defects presents a strong dependence on local atomic arrangements. This dependence affects mechanical, magneto-caloric, and magnetization properties. Insights into thermodynamic and magnetic fluctuations at defects in Fe are obtained from first principle analysis by deploying the first principle local self consistent multiple scattering method(LSMS) and Wang-Landau statistical method. The computation of thermodynamic properties requires the sampling of a large number of configurations. To reduce the computational effort a Heisenberg model will be used to speed the configuration sampling procedures. The approach will be demonstrated for Fe systems and will address the magnetic structure of defects. This work was supported by the Center for Defect Physics, an Energy Frontier Research Center funded by the US DoE, Office of Science, Office of Basic Energy Sciences. Calculations performed at the National Center for Computational Sciences.

  3. Pressure-induced phase transitions in acentric BaHf(BO{sub 3}){sub 2}

    SciTech Connect

    Mączka, Mirosław; Szymborska-Małek, Katarzyna; Sousa Pinheiro, Gardenia de; Cavalcante Freire, Paulo Tarso; Majchrowski, Andrzej

    2015-08-15

    High-pressure Raman scattering studies revealed that BaHf(BO{sub 3}){sub 2} is more compressible than calcite-type orthoborates and calcite, aragonite or dolomite carbonates. It undergoes a first-order reversible pressure-induced phase transition in the 3.9–4.4 GPa pressure range. Second structural change is observed at 9.2 GPa. The intermediate phase is most likely trigonal. However, Raman results suggest increase in the number of distinct BO{sub 3} groups from two in the ambient pressure phase to at least three in the intermediate phase. This intermediate phase is also strongly compressible and strong pressure dependence of the lattice modes proves that the main changes under pressure occur within the layers built from BaO{sub 6} and HfO{sub 6} octahedra. The second phase transition leads most likely to lowering of the trigonal symmetry, as evidenced by significant increase of the number of observed bands. The pressure coefficients of the Raman bands of the high-pressure phase are relatively small, suggesting more dense arrangement of the metal–oxygen polyhedra and BO{sub 3} groups in this phase. It is worth noting that the high-pressure phase was not reached in the second compression experiment up to 10 GPa. This behavior can be most likely attributed to worse hydrostatic conditions of the first experiment. - Graphical abstract: Raman spectra of BaHf(BO{sub 3}){sub 2} recorded at different pressures during compression showing onset of pressure-induced phase transitions. - Highlights: • High-pressure Raman spectra were measured for BaHf(BO{sub 3}){sub 2.} • BaHf(BO{sub 3}){sub 2} undergoes a reversible first-order phase transition at 3.9–4.4 GPa into a trigonal phase. • The intermediate trigonal phase is strongly compressible second structural transformation is observed at 9.2 GPa under non-perfect hydrostatic conditions.

  4. Feasibility and effectiveness of a Chen-style Tai Chi programme for stress reduction in junior secondary school students.

    PubMed

    Lee, Linda Y K; Chong, Yeuk Lan; Li, Ngai Yin; Li, Man Chung; Lin, Lai Na; Wong, Lee Yi; Wong, Brian Kit; Yip, Wing Ping; Hon, Cho Hang; Chung, Pui Kuen; Man, Shuk Yee

    2013-04-01

    Stress is common in junior secondary school students (JSSS). This study aimed to determine the feasibility and effectiveness of a Chen-style Tai Chi programme for stress reduction in JSSS. A non-equivalent pre-test/post-test control group design was adopted, and a convenience sample of 69 JSSS was recruited. The experimental group (n = 32) joined a Chen-style Tai Chi programme, which included 10 sessions of 80-minute Tai Chi training (one session per week). The control group (n = 37) proceeded with self-study. Participants' stress levels were assessed using the Perceived Stress Scale. Feasibility was determined as the percentage of participants completing and attending the programme. Effectiveness was measured as the significant difference in changes in stress levels before and after the intervention between the two groups. Results preliminarily supported that the programme was feasible for JSSS. Completion rate was 100%, and attendance rate was 90%. However, no significant difference was noted in changes in stress levels before and after the intervention between the two groups. The potential health benefits of Tai Chi could not be detected owing to the restrictions imposed by the research setting and study limitations. The present study represents initial efforts in this direction and serves as reference for future study. Copyright © 2012 John Wiley & Sons, Ltd.

  5. Structure and luminescence properties of Ce3+ doped KBa1-x(Mg/Zn)xY(BO3)2 and K1-yNayBaY(BO3)2 phosphors evolved from cation substitution

    NASA Astrophysics Data System (ADS)

    Xu, Rui; Liang, Yujun; Liu, Shiqi; Zhu, Yingli; Wu, Xingya; Li, Kai; Zhou, Wei

    2017-08-01

    The tunable blue-emitting KBa1-x(Mg/Zn)xY0.95(BO3)2:0.05Ce3+ and K1-yNayBaY0.95(BO3)2:0.05Ce3+ phosphors have been investigated via cation substitution of Mg2+/Zn2+ for Ba2+ and Na+ for K+ in KBaY(BO3)2 host. The crystal structures, photoluminescence properties, thermal stability and the effect of Mg2+/Zn2+/Na+ concentration on the luminescence characteristics were investigated in detail. The XRD analysis implied that KBa1-x(Mg/Zn)xY(BO3)2 solid solutions were limited, while continuous solid solution was possible in K1-yNayBaY(BO3)2 system. Upon the excitation at 365 nm, the emission peaks of KBa1-x(Mg/Zn)xY0.95(BO3)2:0.05Ce3+ (0 ⩽ x ⩽ 0.6) blue-shifted from 435 to 424 nm, and K1-yNayBaY0.95(BO3)2:0.05Ce3+ (0 ⩽ y ⩽ 1) blue-shifted from 435 to 427 nm with the Mg2+/Zn2+/Na+ doping concentration increase. The thermal stabilities of KBa1-x(Mg/Zn)xY0.95(BO3)2:0.05Ce3+ phosphors were enhanced from 20 °C to 200 °C by increasing the concentration of Mg2+ and Zn2+. The substitution of Na+ for K+ led to a decrease in the proportion of 5D-2F5/2 and 5D-2F7/2 corresponding to the Gaussian fitting of Ce3+ in K1-yNayBaY0.95(BO3)2:0.05Ce3+ phosphors. At the temperature increased, the full width at half maximum of photoluminescence band of K0.8Na0.2BaY0.95(BO3)2:0.05Ce3+ decreased. However, the decreasing trend of FWHM became less obvious with the increasing concentration of Na+ in the temperature dependent photoluminescence spectra of K1-yNayBaY0.95(BO3)2:0.05Ce3+ phosphors.

  6. Victimization in Korean Schools: The Nature, Incidence, and Distinctive Features of Korean Bullying or "Wang-Ta"

    ERIC Educational Resources Information Center

    Koo, Hyojin; Kwak, Keumjoo; Smith, Peter K.

    2008-01-01

    School bullying in South Korea may take different forms from bullying in western societies, and there is little data on its nature and extent nationally. We report results from a nationwide survey on the Korean form of bullying, "wang-ta". Two pilot studies were carried out, to adapt a western-based questionnaire for use in Korea. With…

  7. A new species and new records of the leafhopper genus Taperus Li & Wang, 1994 (Hemiptera,Cicadellidae, Evacanthinae) from China

    PubMed Central

    Li, Yu-jian; Li, Zi-zhong

    2011-01-01

    Abstract The paper deals with the species of the Oriental leafhopper genus Taperus Li & Wang. A new species, Taperus daozhenensis sp. n., from Guizhou Province, China is described and new records for other Chinese species are given together with a key for their separation. The type specimens of the new species are deposited in the Institute of Entomology, Guizhou University (GUGC). PMID:21998519

  8. Why Three Heads Are a Better Bet than Four: A Reply to Sun, Tweney, and Wang (2010)

    ERIC Educational Resources Information Center

    Hahn, Ulrike; Warren, Paul A.

    2010-01-01

    We (Hahn & Warren, 2009) recently proposed a new account of the systematic errors and biases that appear to be present in people's perception of randomly generated events. In a comment on that article, Sun, Tweney, and Wang (2010) critiqued our treatment of the gambler's fallacy. We had argued that this fallacy was less gross an error than it…

  9. Why Three Heads Are a Better Bet than Four: A Reply to Sun, Tweney, and Wang (2010)

    ERIC Educational Resources Information Center

    Hahn, Ulrike; Warren, Paul A.

    2010-01-01

    We (Hahn & Warren, 2009) recently proposed a new account of the systematic errors and biases that appear to be present in people's perception of randomly generated events. In a comment on that article, Sun, Tweney, and Wang (2010) critiqued our treatment of the gambler's fallacy. We had argued that this fallacy was less gross an error than it…

  10. InBO3 and ScBO3 at high pressures: An ab initio study of elastic and thermodynamic properties

    NASA Astrophysics Data System (ADS)

    Gomis, O.; Ortiz, H. M.; Sans, J. A.; Manjón, F. J.; Santamaría-Pérez, D.; Rodríguez-Hernández, P.; Muñoz, A.

    2016-11-01

    We have theoretically investigated the elastic properties of calcite-type orthoborates ABO3 (A=Sc and In) at high pressure by means of ab initio total-energy calculations. From the elastic stiffness coefficients, we have obtained the elastic moduli (B, G and E), Poisson's ratio (ν), B/G ratio, universal elastic anisotropy index (AU), Vickers hardness, and sound wave velocities for both orthoborates. Our simulations show that both borates are more resistive to volume compression than to shear deformation (B>G). Both compounds are ductile and become more ductile, with an increasing elastic anisotropy, as pressure increases. We have also calculated some thermodynamic properties, like Debye temperature and minimum thermal conductivity. Finally, we have evaluated the theoretical mechanical stability of both borates at high hydrostatic pressures. It has been found that the calcite-type structure of InBO3 and ScBO3 becomes mechanically unstable at pressures beyond 56.2 and 57.7 GPa, respectively.

  11. Isolation of pathogenic Yersinia enterocolitica 1B/O:8 from Apodemus mice in Japan.

    PubMed

    Oda, Shinya; Kabeya, Hidenori; Sato, Shingo; Shimonagane, Ai; Inoue, Kai; Hayashidani, Hideki; Takada, Nobuhiro; Fujita, Hiromi; Kawabata, Hiroki; Maruyama, Soichi

    2015-01-01

    Yersinia enterocolitica was isolated from 15.7% (88/560) of wild rodents captured in 15 prefectures in Japan. Prevalences by rodent species were 18.0% (70/388) in Japanese field mice (Apodemus speciosus), 20% (14/71) in small Japanese field mice (Apodemus argenteus), and 11% (4/38) in gray red-backed vole (Myodes rufocanus bedfordiae), suggesting that these rodent species are important reservoirs of Y. enterocolitica. Although most of the isolates were identified as biotype 1A, the pathogenic bioserotype 1B/O:8 was detected in one of the A. speciosus and in three of the A. argenteus captured in Aomori Prefecture. It is suggested that Apodemus mice may be an important reservoir of Y. enterocolitica, and that there are foci of the pathogenic bioserotype 1B/O:8 in Aomori Prefecture, because human sporadic cases by the serotype have been reported in this prefecture.

  12. The origin of hyperferroelectricity in LiBO3 (B = V, Nb, Ta, Os)

    PubMed Central

    Li, Pengfei; Ren, Xinguo; Guo, Guang-Can; He, Lixin

    2016-01-01

    The electronic and structural properties of LiBO3 (B = V, Nb, Ta, Os) are investigated via first-principles methods. We show that LiBO3 belong to the recently proposed hyperferroelectrics (hyperFEs), i.e., they all have unstable longitudinal optic phonon modes. Especially, the ferroelectric-like instability in the metal LiOsO3, whose optical dielectric constant goes to infinity, is a limiting case of hyperFEs. Via an effective Hamiltonian, we further show that, in contrast to normal proper ferroelectricity, in which the ferroelectric instability usually comes from long-range coulomb interactions, the hyperFE instability is due to the structure instability driven by short-range interactions. This could happen in systems with large ion size mismatches, which therefore provides a useful guidance in searching for novel hyperFEs. PMID:27694996

  13. Phase transitions and exchange interactions in the SmCr3(BO3)4 crystal

    NASA Astrophysics Data System (ADS)

    Dobretsova, E. A.; Boldyrev, K. N.; Popova, M. N.; Gavrilkin, S. Yu.; Mukhin, A. A.; Ivanov, V. Yu.; Mal'tsev, V. V.; Leonyuk, N. I.; Malkin, B. Z.

    2017-01-01

    Spectroscopic investigation and specific heat and magnetic susceptibility measurements of SmCr3(BO3)4 crystals were performed. The spectra of the Sm3+ and Cr3+ ions in samarium chromium borate were calculated and parameters of the exchange interactions between the nearest chromium ions, chromium and samarium ions were determined. Three phase transitions were observed at the temperatures T1 = 7.8 ± 0.5 K, T2 = 6.7 ± 0.5 K, and T3 = 4.3 ± 0.2 K, their nature is discussed. The crystal structures with different space symmetry groups R32 and C2/c were found to coexist in a SmCr3(BO3)4 single crystal.

  14. Period change investigation of the low mass ratio contact binary BO Ari

    NASA Astrophysics Data System (ADS)

    Kriwattanawong, W.; Tasuya, O.; Poojon, P.

    2016-04-01

    A photometric study and period change analysis for the A-type low mass ratio contact binary BO Ari is presented. The BVR light curves were fitted by using the Wilson-Devinney method. The photometric solution yields a low mass ratio of q = 0.1754(±0.0016) with a contact degree of f = 27.72%(±2.37%). We found a long-term orbital period decrease at a rate of dPdt = - 3.49 ×10-7 d yr-1. This result indicates that the system is undergoing mass transfer from the primary component to the secondary with a mass transfer rate of m˙1m1 = - 7.77 ×10-8 yr-1. With the period decrease, the inner and outer critical Roche surfaces will tighten and cause the degree of contact to increase. Therefore, BO Ari may evolve into a deeper contact system.

  15. Growth of (Er,Yb):YAl{sub 3}(BO{sub 3}){sub 4} laser crystals

    SciTech Connect

    Pilipenko, O. V. Mal'tsev, V. V.; Koporulina, E. V.; Leonyuk, N. I.; Tolstik, N. A.; Kuleshov, N. V.

    2008-03-15

    (Er,Yb):YAl{sub 3}(BO{sub 3}){sub 4} single crystals of optical quality, up to 15 x 10 x 10 mm{sup 3} in size, have been grown from a (Er{sub 0.023}Yb{sub 0.116}Y{sub 0.862})Al{sub 3}(BO{sub 3}){sub 4} solution in a Y{sub 2}O{sub 3}-B{sub 2}O{sub 3}-K{sub 2}Mo{sub 3}O{sub 10} melt. The initial borate concentration was 17 wt %, and the flux cooling rate increased from 0.08 to 0.12 deg. C/h in the range 1060-1000 deg. C. The physical properties of the single crystals grown are good enough that they can be used as laser elements in systems with diode pumping and radiation near 1.5 {mu}m.

  16. The origin of hyperferroelectricity in LiBO3 (B = V, Nb, Ta, Os)

    NASA Astrophysics Data System (ADS)

    Li, Pengfei; Ren, Xinguo; Guo, Guang-Can; He, Lixin

    2016-10-01

    The electronic and structural properties of LiBO3 (B = V, Nb, Ta, Os) are investigated via first-principles methods. We show that LiBO3 belong to the recently proposed hyperferroelectrics (hyperFEs), i.e., they all have unstable longitudinal optic phonon modes. Especially, the ferroelectric-like instability in the metal LiOsO3, whose optical dielectric constant goes to infinity, is a limiting case of hyperFEs. Via an effective Hamiltonian, we further show that, in contrast to normal proper ferroelectricity, in which the ferroelectric instability usually comes from long-range coulomb interactions, the hyperFE instability is due to the structure instability driven by short-range interactions. This could happen in systems with large ion size mismatches, which therefore provides a useful guidance in searching for novel hyperFEs.

  17. [Bovine herpesvirus 4 (BoHV-4): general aspects of the biology and status in Argentina].

    PubMed

    Morán, Pedro E; Pérez, Sandra E; Odeón, Anselmo C; Verna, Andrea E

    2015-01-01

    Bovine herpesvirus 4 (BoHV-4) has been isolated from cattle with respiratory infections, vulvovaginitis, mastitis, abortions, endometritis and from apparently healthy animals throughout the world. Although it has not yet been established as causal agent of a specific disease entity, it is primarily associated with reproductive disorders of cattle. This virus can infect a wide range of species, either in vivo or in vitro. Two groups of prototype strains were originated from the first isolates: the DN599-type strains (American group) and the Movar-type strains (European group). In Argentina, BoHV-4 was isolated and characterized in 2007 from vaginal discharge samples taken from cows that had aborted. So far, more than 40 isolates, mainly associated with aborting bovine females have been registered in our country.

  18. Phase transitions and exchange interactions in the SmCr3(BO3)4 crystal

    NASA Astrophysics Data System (ADS)

    Dobretsova, E. A.; Boldyrev, K. N.; Popova, M. N.; Gavrilkin, S. Yu.; Mukhin, A. A.; Ivanov, V. Yu.; Mal'tsev, V. V.; Leonyuk, N. I.; Malkin, B. Z.

    2016-12-01

    Spectroscopic investigation and specific heat and magnetic susceptibility measurements of SmCr3(BO3)4 crystals were performed. The spectra of the Sm3+ and Cr3+ ions in samarium chromium borate were calculated and parameters of the exchange interactions between the nearest chromium ions, chromium and samarium ions were determined. Three phase transitions were observed at the temperatures T1 = 7.8 ± 0.5 K, T2 = 6.7 ± 0.5 K, and T3 = 4.3 ± 0.2 K, their nature is discussed. The crystal structures with different space symmetry groups R32 and C2/c were found to coexist in a SmCr3(BO3)4 single crystal.

  19. Botulinum Toxin Type-A (BoNT-A) Injections of the Corrugator Muscles for Aesthetics and Depression?

    PubMed

    Brennan, Connie

    The treatment of glabellar lines with botulinum toxin type-A (BoNT-A) is a staple for aesthetic providers who specialize in facial rejuvenation. Clinical efforts are currently underway to substantiate upper facial injections (the corrugator muscles are the target muscles) of BoNT-A as an antidepression therapy. This article describes the origin of "facial feedback" by Charles Darwin nearly 150 years ago, as well as "emotional proprioception"-2 neuroanatomical concepts that help provide the scientific rationale behind the general influence facial muscles have on the emotional centers of the brain, and, specifically, how the corrugator muscles-involved with frowning-promote a gloomy mood. The journey researchers have taken to clinically qualify BoNT-A injections of the corrugator muscles-to inhibit frowning, and thereby mitigate depression-will also be highlighted so that aesthetic providers are up to date on this emerging benefit of BoNT-A.

  20. Structural and optical properties of NdxGd1-xCr3(BO3)4 solid solutions

    NASA Astrophysics Data System (ADS)

    Dobretsova, E. A.; Boldyrev, K. N.; Borovikova, E. Yu.; Chernyshev, V. A.

    2016-12-01

    The spectroscopic investigation of the solid solutions GdCr3(BO3)4 (sp.gr. R32) - NdCr3(BO3)4 (sp.gr. C2/c) is presented. The single crystals NdxGd1-xCr3(BO3)4, 0≤x≤1 with the step of 0.1, were grown by a flux method. Crystal structures were identified by terahertz and optical spectroscopy methods. Ab initio calculations in the frame of density functional theory allowed us to separate modes belonging to the R32 and C2/c phases and to estimate the ratio of these phases in NdxGd1-xCr3(BO3)4 crystals. Content of the monoclinic phase (C2/c) increases with growth of the Nd concentration.

  1. Structure and optical properties of a noncentrosymmetric borate RbSr{sub 4}(BO{sub 3}){sub 3}

    SciTech Connect

    Xia, M.J.; Li, R.K.

    2013-01-15

    A new noncentrosymmetric borate, RbSr{sub 4}(BO{sub 3}){sub 3} (abbreviated as RSBO), has been grown from Rb{sub 2}O--B{sub 2}O{sub 3}--RbF flux and its crystal structure was determined by single crystal x-ray diffraction. It crystallizes in space group Ama2 with cell parameters of a=11.128(10) A, b=12.155(15) A, c=6.952(7) A, Z=4. The basic structural units are isolated planar BO{sub 3} groups. Second harmonic generation (SHG) test of the title compound by the Kurtz-Perry method shows that RSBO can be phase matchable with an effective SHG coefficient about two-thirds as large as that of KH{sub 2}PO{sub 4} (KDP). Finally, based on the anionic group approximation, the optical properties of the title compound are compared with those of the structure-related apatite-like compounds with the formula 'A{sub 5}(TO{sub n}){sub 3}X'. - Graphical abstract: RbSr{sub 4}(BO{sub 3}){sub 3} and some other borate NLO compounds, namely Ca{sub 5}(BO{sub 3}){sub 3}F RCa{sub 4}(BO{sub 3}){sub 3}O (R=Y or Gd) and Na{sub 3}La{sub 2}(BO{sub 3}){sub 3} can be viewed as the derivatives of apatite. They have similar formula composed of five cations and three anion groups (we call them 5/3 structures). The detailed SHG coefficients and optical properties of the apatite-like NLO crystals were compared and summarized. Highlights: Black-Right-Pointing-Pointer A new noncentrosymmetric borate RbSr{sub 4}(BO{sub 3}){sub 3} was grown from flux. Black-Right-Pointing-Pointer The RbSr{sub 4}(BO{sub 3}){sub 3} can be viewed as a derivative of the apatite-like structure. Black-Right-Pointing-Pointer The structure and its relationship to the optical properties of RbSr{sub 4}(BO{sub 3}){sub 3} are compared with other NLO crystals with apatite-like structures. Black-Right-Pointing-Pointer The basic structural units are the planar BO{sub 3} groups in the structure. Black-Right-Pointing-Pointer Second harmonic generation (SHG) test shows that RbSr{sub 4}(BO{sub 3}){sub 3} can be phase matchable with an

  2. Seasonality of Yersinia enterocolitica bioserotype 1B/O:8 infections in Poland.

    PubMed

    Rastawicki, W; Szych, J; Rokosz, N; Zacharczuk, K; Gierczyński, R

    2013-10-01

    Both serological and bacteriological investigations revealed a cyclic, seasonal pattern of Yersinia enterocolitica 1B/O8 infections in Poland during the years 2008–2011. A large increase in incidence was observed in the second quarter and a decrease in the third quarter of each year. Such seasonal changes were not seen in the case of infections caused by the other enteropathogenic Yersinia bioserotypes.

  3. Working Report on Visible and IR Electromagnetic Emissions from HMMWV External Black-Out (BO) Lighting

    DTIC Science & Technology

    2004-10-14

    with the turn signal on data, (e) Service light on data, (f) Service light with filters mounted data (c) (b) (d) (a) (e) (f) BO Drive Lamp...Front Composite/ Turn signal on Filter mounted Truck-Lite RC First Truck-Lite RC First Visible YES (47) YES (44) NO (50) Data not available Visible...Headlamp Truck-Lite RC First Truck-Lite RC First Front composite Front composite Turn signal Turn signal Visible Detect (63) Not Detect (63) Not

  4. Direct Electrochemistry of Cytochrome bo3 Oxidase at a series of Gold Nanoparticles-Modified Electrodes

    PubMed Central

    Melin, Frederic; Meyer, Thomas; Lankiang, Styven; Choi, Sylvia K.; Gennis, Robert B; Blanck, Christian; Schmutz, Marc; Hellwig, Petra

    2012-01-01

    New membrane-protein based electrodes were prepared incorporating cytochrome bo3 from E. coli and gold nanoparticles. Direct electron transfer between the electrode and the immobilized enzymes was achieved, resulting in an electrocatalytic activity in presence of O2. The size of the gold nanoparticles was shown to be important and smaller particles were shown to reduce the overpotential of the process. PMID:23335854

  5. BO Canum Venaticorum and SS Comae Berenices: A Photometric Study of AW UMa-Type Binaries

    NASA Astrophysics Data System (ADS)

    Qian, S.-B.; Zhu, L.-Y.

    2006-02-01

    BO CVn and SS Com are two short-period W UMa-type binary stars with spectral types earlier than F5. In the present paper new CCD photometric light curves in B, V, and R bands of BO CVn and the first complete light curve in V band of SS Com are presented. The light curves of the two binaries are symmetric, and no variations of the light curves were found for both systems that are quite unlike those of cooler overcontact binaries. These observational properties may suggest weak photospheric dark spot activity in the two systems during the observational time intervals. Photometric solutions of the two W UMa-type binaries were derived by using the 2003 version of the Wilson-Devinney (W-D) method. The new solutions suggest that they are overcontact binary stars with degrees of overcontact of f=40.6% for BO CVn and f=49.6% for SS Com. Our new times of light minimum confirmed the long-time period increases of the two systems, and the rates of continuous period increase were revised. The long-time period increases, the orbital periods, the degrees of overcontact, and the mass ratios all suggest that they are on an evolutionary stage of mass transfer from the less massive component to the more massive one, and SS Com will reach the present evolutionary state of BO CVn. The slow evolution toward extreme mass ratio will cause them finally to coalesce to single stars. Therefore, both of them are AW UMa-type near-coalescent overcontact binary systems.

  6. Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.

    PubMed

    Singh, Padma; Singh, Manglesh Kumar; Chaudhary, Dilip; Chauhan, Vinita; Bharadwaj, Pranay; Pandey, Apurva; Upadhyay, Nisha; Dhaked, Ram Kumar

    2012-01-01

    Botulinum neurotoxins (BoNTs), etiological agents of the life threatening neuroparalytic disease botulism, are the most toxic substances currently known. The potential for the use as bioweapon makes the development of small-molecule inhibitor against these deadly toxins is a top priority. Currently, there are no approved pharmacological treatments for BoNT intoxication. Although an effective vaccine/immunotherapy is available for immuno-prophylaxis but this cannot reverse the effects of toxin inside neurons. A small-molecule pharmacological intervention, especially one that would be effective against the light chain protease, would be highly desirable. Similarity search was carried out from ChemBridge and NSC libraries to the hit (7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol; NSC 84096) to mine its analogs. Several hits obtained were screened for in silico inhibition using AutoDock 4.1 and 19 new molecules selected based on binding energy and Ki. Among these, eleven quinolinol derivatives potently inhibited in vitro endopeptidase activity of botulinum neurotoxin type A light chain (rBoNT/A-LC) on synaptosomes isolated from rat brain which simulate the in vivo system. Five of these inhibitor molecules exhibited IC(50) values ranging from 3.0 nM to 10.0 µM. NSC 84087 is the most potent inhibitor reported so far, found to be a promising lead for therapeutic development, as it exhibits no toxicity, and is able to protect animals from pre and post challenge of botulinum neurotoxin type A (BoNT/A).

  7. Small-Molecule Quinolinol Inhibitor Identified Provides Protection against BoNT/A in Mice

    PubMed Central

    Singh, Padma; Singh, Manglesh Kumar; Chaudhary, Dilip; Chauhan, Vinita; Bharadwaj, Pranay; Pandey, Apurva; Upadhyay, Nisha; Dhaked, Ram Kumar

    2012-01-01

    Botulinum neurotoxins (BoNTs), etiological agents of the life threatening neuroparalytic disease botulism, are the most toxic substances currently known. The potential for the use as bioweapon makes the development of small-molecule inhibitor against these deadly toxins is a top priority. Currently, there are no approved pharmacological treatments for BoNT intoxication. Although an effective vaccine/immunotherapy is available for immuno-prophylaxis but this cannot reverse the effects of toxin inside neurons. A small-molecule pharmacological intervention, especially one that would be effective against the light chain protease, would be highly desirable. Similarity search was carried out from ChemBridge and NSC libraries to the hit (7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol; NSC 84096) to mine its analogs. Several hits obtained were screened for in silico inhibition using AutoDock 4.1 and 19 new molecules selected based on binding energy and Ki. Among these, eleven quinolinol derivatives potently inhibited in vitro endopeptidase activity of botulinum neurotoxin type A light chain (rBoNT/A-LC) on synaptosomes isolated from rat brain which simulate the in vivo system. Five of these inhibitor molecules exhibited IC50 values ranging from 3.0 nM to 10.0 µM. NSC 84087 is the most potent inhibitor reported so far, found to be a promising lead for therapeutic development, as it exhibits no toxicity, and is able to protect animals from pre and post challenge of botulinum neurotoxin type A (BoNT/A). PMID:23071727

  8. Effect of botulinum neurotoxin type A (BoNTA) on the morphology and viability of 3T3 murine fibroblasts

    PubMed Central

    Bandala, Cindy; Terán-Melo, Juan Luis; Anaya-Ruiz, Maricruz; Mejía-Barradas, Cesar Miguel; Domínguez-Rubio, Rene; la Garza-Montano, Paloma De; Alfaro-Rodríguez, Alfonso; Lara-Padilla, Eleazar

    2015-01-01

    Aim: BoNTA is used in the treatment of ophthalmological disorders, muscular hyperactivity and pain. In recent years it has been described that BoNTA reduces cellular viability and induces apoptosis in prostate cells lines. Studies about the effect of BoNTA are no well known. There have been studies about the effect of BoNTA on the expression levels of collagenase in fibroblasts, but not on its morphological impact on these cells. The aim of this study was to determine the effect of BoNTA on the morphology and viability of the 3T3 fibroblast cell line. Material and methods: The 3T3 fibroblast cell line was cultured and the experimental group received 10 U BoNTA added to a 0.9% sterile saline solution in a reconstituted vial. The control group received saline solution only. Cultured cells were observed and photographed at 5, 10, 15 and 20 h. Cell viability was evaluated by means of the trypan blue test, and cell proliferation with the Proliferation Assay kit (PROMEGA). Results: The application of BoNTA to 3T3 fibroblast cells induced morphological changes, such as a loss of normal fibroblast morphology. Additionally, we observed the cytoplasmic retraction and spread phenomena. The nuclei showed other important changes with Giemsa staining. Conclusion: The results indicate that BoNTA induced a loss of spindle form, increase in cytoplasmic vesicles, and the presence of nuclear vesicles (compacted chromatin surrounded by a nuclear envelope). This suggests an apoptotic process and decreased cell viability. Further studies are needed to explore the mechanisms of these alterations. PMID:26464704

  9. Permanent draft genome sequences of the symbiotic nitrogen fixing Ensifer meliloti strains BO21CC and AK58

    PubMed Central

    Galardini, Marco; Bazzicalupo, Marco; Biondi, Emanuele; Brambilla, Eveline; Brilli, Matteo; Bruce, David; Chain, Patrick; Chen, Amy; Daligault, Hajnalka; Davenport, Karen Walston; Deshpande, Shweta; Detter, John C.; Goodwin, Lynne A.; Han, Cliff; Han, James; Huntemann, Marcel; Ivanova, Natalia; Klenk, Hans-Peter; Kyrpides, Nikos C.; Markowitz, Victor; Mavrommatis, Kostas; Mocali, Stefano; Nolan, Matt; Pagani, Ioanna; Pati, Amrita; Pini, Francesco; Pitluck, Sam; Spini, Giulia; Szeto, Ernest; Teshima, Hazuki; Woyke, Tanja; Mengoni, Alessio

    2013-01-01

    Ensifer (syn. Sinorhizobium) meliloti is an important symbiotic bacterial species that fixes nitrogen. Strains BO21CC and AK58 were previously investigated for their substrate utilization and their plant-growth promoting abilities showing interesting features. Here, we describe the complete genome sequence and annotation of these strains. BO21CC and AK58 genomes are 6,985,065 and 6,974,333 bp long with 6,746 and 6,992 genes predicted, respectively. PMID:24976889

  10. Permanent draft genome sequences of the symbiotic nitrogen fixing Ensifer meliloti strains BO21CC and AK58.

    PubMed

    Galardini, Marco; Bazzicalupo, Marco; Biondi, Emanuele; Brambilla, Eveline; Brilli, Matteo; Bruce, David; Chain, Patrick; Chen, Amy; Daligault, Hajnalka; Davenport, Karen Walston; Deshpande, Shweta; Detter, John C; Goodwin, Lynne A; Han, Cliff; Han, James; Huntemann, Marcel; Ivanova, Natalia; Klenk, Hans-Peter; Kyrpides, Nikos C; Markowitz, Victor; Mavrommatis, Kostas; Mocali, Stefano; Nolan, Matt; Pagani, Ioanna; Pati, Amrita; Pini, Francesco; Pitluck, Sam; Spini, Giulia; Szeto, Ernest; Teshima, Hazuki; Woyke, Tanja; Mengoni, Alessio

    2013-12-20

    Ensifer (syn. Sinorhizobium) meliloti is an important symbiotic bacterial species that fixes nitrogen. Strains BO21CC and AK58 were previously investigated for their substrate utilization and their plant-growth promoting abilities showing interesting features. Here, we describe the complete genome sequence and annotation of these strains. BO21CC and AK58 genomes are 6,985,065 and 6,974,333 bp long with 6,746 and 6,992 genes predicted, respectively.

  11. Ab initio structure determination of novel borate NaSrBO 3

    NASA Astrophysics Data System (ADS)

    Wu, L.; Chen, X. L.; Zhang, Y.; Kong, Y. F.; Xu, J. J.; Xu, Y. P.

    2006-04-01

    A novel orthoborate, NaSrBO 3, has been successfully synthesized by standard solid-state reaction, and the crystal structure has been determined from powder X-ray diffraction data. It crystallizes in the monoclinic space group P2/c with lattice parameters: a=5.32446(7) Å, b=9.2684(1) Å, c=6.06683(8) Å, β=100.589(1)°. The fundamental building units are isolated BO 3 groups, which are parallelly distributed along two different directions. Because of the anisotropic polarizations of planar BO 3 groups, a considerable birefringence can be expected in it. The Na atoms are six-coordinated with O atoms to form octahedra, and the Sr atoms are nine-coordinated, forming tri-capped trigonal prisms. Those polyhedra connect with each other by bridging-oxygen atoms, forming infinite three-dimensional network, which indicates that the cleaving problem is expected to be overcome during the course of single-crystal growth. The infrared spectrum has been measured, and the result is consistent with the crystallographic study. Moreover, a comparison of the new structure type with the other known orthoborates is presented here.

  12. Bovine alloreactive cytotoxic cells generated in vitro: target specificity in relation to BoLA phenotype.

    PubMed Central

    Teale, A J; Morrison, W I; Goddeeris, B M; Groocock, C M; Stagg, D A; Spooner, R L

    1985-01-01

    Cytotoxic cells of bovine origin were generated in primary MLC using stimulator cells of BoLA w8/w11 phenotype. Bovine lymphoblasts transformed by the protozoan parasite Theileria parva parva acted as target cells in studies of the specificity of cytotoxicity. When responder cells in MLC did not share w8 or w11 with stimulator cells, cytotoxicity was evident with all targets bearing w8 or w11, or both, and was almost entirely restricted to these products of the BoLA-A locus. When responder and stimulator cells shared both w8 and w11, cytotoxicity was also generated. Whether this was specific for the products of other putative Class I loci in cattle, or for the products of a Class II region, remains to be determined. These results suggest that the determinants recognized by appropriately generated bovine alloreactive cytotoxic cells are identical with, or closely related to, determinants characterized by BoLA w8 and w11 defining alloantisera. PMID:2409001

  13. BoCluSt: Bootstrap Clustering Stability Algorithm for Community Detection.

    PubMed

    Garcia, Carlos

    2016-01-01

    The identification of modules or communities in sets of related variables is a key step in the analysis and modeling of biological systems. Procedures for this identification are usually designed to allow fast analyses of very large datasets and may produce suboptimal results when these sets are of a small to moderate size. This article introduces BoCluSt, a new, somewhat more computationally intensive, community detection procedure that is based on combining a clustering algorithm with a measure of stability under bootstrap resampling. Both computer simulation and analyses of experimental data showed that BoCluSt can outperform current procedures in the identification of multiple modules in data sets with a moderate number of variables. In addition, the procedure provides users with a null distribution of results to evaluate the support for the existence of community structure in the data. BoCluSt takes individual measures for a set of variables as input, and may be a valuable and robust exploratory tool of network analysis, as it provides 1) an estimation of the best partition of variables into modules, 2) a measure of the support for the existence of modular structures, and 3) an overall description of the whole structure, which may reveal hierarchical modular situations, in which modules are composed of smaller sub-modules.

  14. Structural and luminescent properties of KY(1-x)DyxBO3 phosphors

    NASA Astrophysics Data System (ADS)

    Sowjanya, G.; Rama Moorthy, L.; Basavapoornima, Ch.; Jayasankar, C. K.

    2017-01-01

    Yttrium borate phosphors (KY(1-x)DyxBO3) doped with Dy3+ ions were synthesized by the solid-state reaction method. The structural and morphological characteristics were studied by XRD, FTIR and SEM measurements. Luminescent properties of different concentrations of KY(1-x)DyxBO3 phosphors were investigated from the excitation, emission and decay analyses. The emission spectra exhibited characteristic blue (460-500 nm) and yellow (555-610 nm) bands of Dy3+ ions which combines to give white light. The evaluated color co-ordinates (x, y) were found to lie within the white light region of CIE chromaticity diagram. All the decay curves of Dy3+ ions exhibited non-exponential nature and the experimental lifetimes for the 4F9/2 excited level were found to decrease from 0.87, 0.47, 0.35, 0.26 and 0.13 ms with the increase of Dy3+ ion concentrations from 0.05, 0.1, 0.15, 0.2 and 0.3 mol%, respectively. In order to understand the energy transfer mechanism, the decay curves were fitted to Inokutti-Hirayama model and found that the energy transfer is of dipole-dipole type. From the results of these investigations, it is concluded that the KY(1-x)DyxBO3 phosphors are more useful for white light emitting diodes.

  15. Complete sequence and phylogenetic analysis of a porcine bocavirus strain swBoV CH437.

    PubMed

    Wang, Enli; Liu, Wei; Yang, Bin; Liu, Jixing; Ma, Xiaojun; Lan, Xi

    2014-04-01

    Porcine bocavirus (PBoV), a member of genus Bocavirus, family Parvoviridae, was first identified in 2009 in Swedish swine herds suffering from postweaning multisystemic wasting syndrome. Up to date, the different species of PBoVs have been reported in different countries. Especially, the virus isolated in China was complicated. In this study, we detected a novel PBoV strain swBoV CH437 from clinical samples collected in Gansu Province, Northwest China. The complete genome of swBoV CH437 was 5,275 nucleotides (nt) in length and contains three ORFs: ORF1 encodes NS1 (2,004 nt, 667 aa), ORF3 encodes NP1 (681 nt, 226 aa), and ORF2 encodes VP1 (2,049 nt, 682 aa) and VP2 (1,641 nt, 546 aa). Sequence analysis demonstrated that the NS1 gene shared 24.2-88.6 % nucleotide sequence identity, the NP1 shared 21.3-89.9 %, less than 95 % nucleotide sequence identity with other PBoV strains. Therefore, we propose that swBoV CH437 should be classified as a novel PBoV species.

  16. Magnetic resonances of multiferroic TbFe3(BO3)4

    NASA Astrophysics Data System (ADS)

    Szaller, Dávid; Kocsis, Vilmos; Bordács, Sándor; Fehér, Titusz; Rõõm, Toomas; Nagel, Urmas; Engelkamp, Hans; Ohgushi, Kenya; Kézsmárki, István

    2017-01-01

    Low-energy magnetic excitations of the easy-axis antiferromagnet TbFe3(BO3)4 are investigated by far-infrared absorption and reflection spectroscopy in high magnetic fields up to 30 T. The observed field dependence of the resonance frequencies and the magnetization are reproduced by a mean-field spin model for magnetic fields applied both along and perpendicular to the easy axis. Based on this model we determined the full set of magnetic interactions, including Fe-Fe and Fe-Tb exchange interactions, single-ion anisotropy for Tb ions and g factors, which describe the ground-state spin texture and the low-energy spin excitations of TbFe3(BO3)4 . Compared to earlier studies, we allow a small canting of the nearly Ising-type Tb moments to achieve a quantitative agreement with the magnetic susceptibility measurements. The additional high-energy magnetic resonance lines observed, besides the two resonances expected for a two-sublattice antiferromagnet, suggest a more complex six-sublattice magnetic ground state for TbFe3(BO3)4 .

  17. Nonlinear optical properties of LaCa(4)O(BO(3))(3).

    PubMed

    Adams, J J; Ebbers, C A; Schaffers, K I; Payne, S A

    2001-02-15

    We have grown LaCa(4)O (BO(3))(3) (LaCOB), an isostructural member of GdCa(4)O(BO(3))(3) (GdCOB) family and characterized its nonlinear optical properties. At 1064nm, d(eff) of 0.52+/-0.05 pm /V and an angular sensitivity of 1224+/-184(cm rad)(-1) for type I frequency doubling in LaCOB were determined relative to those of KTiOPO(4) , beta-BaB(2)O(4) , KD(2)PO(4) , LiB(3)O(5) , YCa(4)O(BO(3))(3) (YCOB), and GdCOB. The d(alphabetabeta) and d(gammabetabeta) coefficients of the nonlinear optical tensor for LaCOB, GdCOB, and YCOB were determined to be equivalent within the experimental uncertainty and have values of ?0.26+/-0.04?pm/V and ?1.69+/-0.17?pm /V , respectively. From phase-matching angle measurements at 1064 and 1047nm, we predict that LaCOB is noncritically phase matched at 1042+/-1.5 nm .

  18. Elementary model of severe plastic deformation by KoBo process

    SciTech Connect

    Gusak, A.; Storozhuk, N.; Danielewski, M. Korbel, A.; Bochniak, M.

    2014-01-21

    Self-consistent model of generation, interaction, and annihilation of point defects in the gradient of oscillating stresses is presented. This model describes the recently suggested method of severe plastic deformation by combination of pressure and oscillating rotations of the die along the billet axis (KoBo process). Model provides the existence of distinct zone of reduced viscosity with sharply increased concentration of point defects. This zone provides the high extrusion velocity. Presented model confirms that the Severe Plastic Deformation (SPD) in KoBo may be treated as non-equilibrium phase transition of abrupt drop of viscosity in rather well defined spatial zone. In this very zone, an intensive lateral rotational movement proceeds together with generation of point defects which in self-organized manner make rotation possible by the decrease of viscosity. The special properties of material under KoBo version of SPD can be described without using the concepts of nonequilibrium grain boundaries, ballistic jumps and amorphization. The model can be extended to include different SPD processes.

  19. Elementary model of severe plastic deformation by KoBo process

    NASA Astrophysics Data System (ADS)

    Gusak, A.; Danielewski, M.; Korbel, A.; Bochniak, M.; Storozhuk, N.

    2014-01-01

    Self-consistent model of generation, interaction, and annihilation of point defects in the gradient of oscillating stresses is presented. This model describes the recently suggested method of severe plastic deformation by combination of pressure and oscillating rotations of the die along the billet axis (KoBo process). Model provides the existence of distinct zone of reduced viscosity with sharply increased concentration of point defects. This zone provides the high extrusion velocity. Presented model confirms that the Severe Plastic Deformation (SPD) in KoBo may be treated as non-equilibrium phase transition of abrupt drop of viscosity in rather well defined spatial zone. In this very zone, an intensive lateral rotational movement proceeds together with generation of point defects which in self-organized manner make rotation possible by the decrease of viscosity. The special properties of material under KoBo version of SPD can be described without using the concepts of nonequilibrium grain boundaries, ballistic jumps and amorphization. The model can be extended to include different SPD processes.

  20. [Prenatal diagnosis of chromosome abnormalities and nine microdeletion syndromes using both traditional karyotyping and BoBs].

    PubMed

    Tang, X H; Yang, B C; Zhu, S; Su, J; Zhang, J M; Yin, Y F; Feng, Y; Li, D M; Zhao, Q F; Yu, R; Zhu, B S

    2016-05-25

    To evaluate a new prenatal diagnosis model of chromosomal abnormalities and nine microdeletion syndromes by using both traditional karyotyping and a newly-developed rapid prenatal diagnosis technology, BACs-on-Beads (BoBs) technique. From June 2012 to December 2014, 807 pregnant women with high risk after screening or with other indicators, were performed amniocentesis. Traditional karyotyping and BoBs were employed simultaneously for prenatal diagnosis. Thirty-two cases with chromosome aneupoidies were successfully detected both by BoBs and karyotyping, including 18 cases of trisomy 21, 6 cases of trisomy 18, 1 case of trisomy 13, and 7 cases with sex chromosome abnormality. All 8 fetuses with chromosome structural abnormalities detected by karyotyping were missed by BoBs; while BoBs contributed more in detection of five microdeletion syndrome cases, including 3 cases of DiGeorge syndromes (two with microduplication and one with microdeletion), one case of Miller-Dieker syndrome, and one case of Wolf-Hirschhorn syndrome. Combined use of traditional karyotyping and BoBs, is a rapid and effective prenatal diagnosis model that may enlarge our horizon on chromosomal diseases and should be widely used in future clinical service.

  1. Characterization and mapping of LanrBo: a locus conferring anthracnose resistance in narrow-leafed lupin (Lupinus angustifolius L.).

    PubMed

    Fischer, Kristin; Dieterich, Regine; Nelson, Matthew N; Kamphuis, Lars G; Singh, Karam B; Rotter, Björn; Krezdorn, Nicolas; Winter, Peter; Wehling, Peter; Ruge-Wehling, Brigitte

    2015-10-01

    A novel and highly effective source of anthracnose resistance in narrow-leafed lupin was identified. Resistance was shown to be governed by a single dominant locus. Molecular markers have been developed, which can be used for selecting resistant genotypes in lupin breeding. A screening for anthracnose resistance of a set of plant genetic resources of narrow-leafed lupin (Lupinus angustifolius L.) identified the breeding line Bo7212 as being highly resistant to anthracnose (Colletotrichum lupini). Segregation analysis indicated that the resistance of Bo7212 is inherited by a single dominant locus. The corresponding resistance gene was given the designation LanrBo. Previously published molecular anchor markers allowed us to locate LanrBo on linkage group NLL-11 of narrow-leafed lupin. Using information from RNAseq data obtained with inoculated resistant vs. susceptible lupin entries as well as EST-sequence information from the model genome Lotus japonicus, additional SNP and EST markers linked to LanrBo were derived. A bracket of two LanrBo-flanking markers allows for precise marker-assisted selection of the novel resistance gene in narrow-leafed lupin breeding programs.

  2. Isolation and characterization of BoHV-1 from seropositive cows after inducing artificial stress in West Bengal, India.

    PubMed

    Saha, Tapabrata; Guha, Chanchal; Chakraborty, Dhruba; Pal, Biplab; Biswas, Ujjwal; Chatterjee, Amaresh; Koenig, Patricia; Beer, Martin

    2013-08-01

    Infectious Bovine Rhinotracheitis (BoHV-1) is the most important emerging disease of cattle in India. With an aim to reactivate BoHV-1 from latently infected sero-positive cattle for molecular characteristics of the isolates prevalent in tropical and sub-tropical countries like India and further epidemiological investigations on IBR infections this study had been conducted. Artificial stress with dexamethasone at the dose rate of 0.1 mg kg(-1) body weight for 5 consecutive days was induced in BoHV-1 sero-positive cows. Then isolation from nasal swabs was attempted in Madin Darby Bovine Kidney (MDBK) cell line to find out the prevalent strain in India. The virus was isolated from all the three cows. All the three isolates were typed as BoHV-1.2 (Strain India 4, India 5 and India 6). The reactivation obtained in this study with dexamethasone suggests the usefulness of BoHV-1 cow latency model for epidemiological investigations on BoHV-1 infections in tropical and sub-tropical countries like India, Pakistan etc.

  3. Polymorphism and gene organization of water buffalo MHC-DQB genes show homology to the BoLA DQB region.

    PubMed

    Sena, L; Schneider, M P C; Brenig, B B; Honeycutt, R L; Honeycutt, D A; Womack, J E; Skow, L C

    2011-08-01

    In cattle (Bos taurus), there is evidence of more than 50 alleles of BoLA-DQB (bovine lymphocyte antigen DQB) that are distributed across at least five DQB loci, making this region one of the most complex in the BoLA gene family. In this study, DQB alleles were analysed for the water buffalo (Bubalus bubalis), another economically important bovine species. Twelve alleles for Bubu-DQB (Bubalis bubalis DQB) were determined by nucleotide sequence analysis. A phylogenetic analysis revealed numerous trans-species polymorphisms, with alleles from water buffalo assigned to at least three different loci (BoLA-DQB1, BoLA-DQB3 and BoLA-DQB4) that are also found in cattle. These presumptive loci were analysed for patterns of synonymous (d(S)) and non-synonymous (d(N)) substitution. Like BoLA-DQB1, Bubu-DQB1 was observed to be under strong positive selection for polymorphism. We conclude that water buffalo and cattle share the current arrangement of their DQB region because of their common ancestry. © 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.

  4. Three new anti-HBV active constituents from the traditional Chinese herb of Yin-Chen (Artemisia scoparia).

    PubMed

    Geng, Chang-An; Huang, Xiao-Yan; Chen, Xing-Long; Ma, Yun-Bao; Rong, Guang-Qing; Zhao, Yong; Zhang, Xue-Mei; Chen, Ji-Jun

    2015-12-24

    Yin-Chen is a famous traditional Chinese medicine (TCM) in China for the treatment of acute and chronic hepatitis. Two species, namely Artemisia scoparia and Artemisia capillaris, are documented in Chinese Pharmacopoeia as the authentic resources for Yin-Chen. Previous investigation has proved that chlorogenic acid analogs and phenolic acids are two main types of the anti-HBV active constituents of A. capillaris. However, there is no investigation concerned with the anti-HBV components of A. scoparia. The aim of the present study is to recognize the new anti-HBV constituents of A. scoparia by detailed LCMS analyses. LCMS and bioassay-guided fractionation on the active part of A. scoparia led to the isolation of three new compounds. Their structures were determined by detailed spectroscopic analyses. Anti-HBV assay involving inhibition on HBsAg and HBeAg secretions and HBV DNA replication were performed in virto on HepG 2.2.15 cell line. The 90% ethanol extract of A. scoparia was revealed with anti-HBV activity for the first time, which was further separated into several fractions by column chromatography. Fr. D-4 was revealed with the highest anti-HBV activity, from which three new compounds including one unusual 4-pyridone glucoside (1) and two polyacetylene glucosides (2-3) were isolated under the guidance of LCMS analyses. Compounds 1-3 exhibited activity against the secretions of HBsAg and HBeAg, and HBV DNA replication. In particular, compounds 2 and 3 inhibited HBV DNA replication with IC50 values of 0.07 ± 0.04 and 0.012 ± 0.05 mM, with SI values of 23.6 and 17.1, respectively. Based on the MS/MS experiment, the fragmentation pathways of 1 in both positive and negative modes, and 2 and 3 in negative mode were proposed. The ion pairs of 388-208 (positive) and 432-206 (negative) for 1, 503-341 (negative) for 2, and 503-203 (negative) for 3, could be recognized as their respective diagnostic ions. The first time investigation on the anti-HBV constituents of A

  5. Beryllium-Free KBBF Family of Nonlinear-Optical Crystals: AZn2BO3X2 (A = Na, K, Rb; X = Cl, Br).

    PubMed

    Huang, Qian; Liu, Lijuan; Wang, Xiaoyang; Li, Rukang; Chen, Chuangtian

    2016-12-19

    A series of a novel beryllium-free KBBF family of nonlinear-optical materials AZn2BO3X2 (A = K, Rb and X = Cl; A = Na, K, Rb and X = Br) were successfully synthesized through molecular engineering design, and single crystals of AZn2BO3Cl2 (A = K, Rb) were grown by a spontaneous nucleation technique from self-flux systems. As a representative for the halogen KBBF family of crystals, KZn2BO3Cl2 features the infinite lattice layer [Zn2BO3Cl2]∞ made up of BO3 and ZnO3Cl anionic groups, and the in-layer BO3 groups are completely coplanar and well-aligned. Besides, KZn2BO3Cl2 exhibits high transmittance in the range of 300-2000 nm with a UV-transmission cutoff of around 200 nm according to transmission spectra. The compounds of AZn2BO3Cl2 (A = K, Rb) are both phase-matchable with powder second-harmonic-generation efficiencies of 1.3 and 1.17 times that of KH2PO4 for KZn2BO3Cl2 and RbZn2BO3Cl2, respectively, which are similar to that of KBBF.

  6. Self-assembly of the recombinant capsid protein of a bovine norovirus (BoNV) into virus-like particles and evaluation of cross-reactivity of BoNV with human noroviruses.

    PubMed

    Han, M G; Wang, Q; Smiley, J R; Chang, K O; Saif, L J

    2005-02-01

    None of the enteric caliciviruses except Po/Sapo/GIII/Cowden/80/US replicates in cell culture, which complicates efforts to develop control strategies or to study viral replication. To develop serological assays for bovine noroviruses (BoNVs) and to determine the cross-reactivity of BoNV with human noroviruses, we generated two recombinant baculoviruses, rCV186-OH and rJNCV, to express the capsid genes of Bo/CV186-OH/00/US (Norovirus genogroup III [GIII], genotype 2 [GIII/2]). rCV186-OH expressed the expected 57-kDa capsid protein, but rJNCV expressed a truncated capsid protein of 35 kDa. Sequence analysis of rJNCV identified a single nucleotide deletion in the P domain of the capsid gene, which introduced a stop codon at amino acid 323. The recombinant capsid protein produced by rCV186-OH but not that produced by rJNCV self-assembled into virus-like particles (VLPs) similar to native BoNV. An antibody-capture enzyme-linked immunosorbent assay (ELISA) and antigen-capture ELISA (Ag-ELISA) detected serum antibody and antigen, respectively, from calves infected with Bo/CV186-OH/00/US but not antibodies or antigens to other enteric viruses. In other tests of the GIII/2 BoNV Ag-ELISA, no cross-reactivity was observed with VLPs from one GI and four GII human noroviruses and porcine sapovirus Cowden strain. Because, like human noroviruses, BoNVs do not grow in cell culture, the BoNV VLPs will be useful in the serological assays described for the detection of BoNV antibody and antigen. Consistent with the phylogenetic analysis of the capsid genes of bovine and human noroviruses (M. G. Han, J. R. Smiley, C. Thomas, and L. J. Saif, J. Clin. Microbiol. 42:5214-5224, 2004), the results suggest that GIII/2 BoNV does not share significant antigenic relationships with the five characterized human noroviruses tested.

  7. [Cerebral paragonimiasis and Bo Sung Sim's hemispherectomy in Korea in 1950s-1960s].

    PubMed

    Park, Jiyoung; Miyagawa, Takuya; Hong, Jeonghwa; Kim, Ockjoo

    2011-06-30

    This paper deals with cerebral paragonimiasis and cerebral hemispherectomy conducted as a treatment of cerebral paragonimiasis by Bo Sung Sim in Korea in 1950s-1960s. He demonstrated that cerebral hemispherectomy could be used for unilateral diffuse cerebral paragonimiasis. Sim learned cerebral hemispherectomy from Dr. L. A. French. at the University of Minnesota from 1955 to 1957 in America. The authors argues that Bo Sung Sim's introduction of cerebral hemispherectomy to Korea was not a simple application of an advanced medical technology, but a complicated and active process in that Sim used the technique to intervene intractable complications from cerebral paragonimiasis such as generalized convulsions, spastic hemiplegia and mental deterioration. Bo Sung Sim, one of the neurosurgeons of the first generation in Korea, was trained in neurology, neuropathology, neuroradiology and animal experiments as well as in neurosurgery at the University of Minnesota. After returning to Korea, Sim faced parasitic diseases, one of the most serious public health problems at that time, which were far different from what he learned in America. As a neurosurgeon, Sim tackled with parasitic diseases of the central nervous system with various diagnostics and therapeutics. In 1950s, more than one million populations suffered from pulmonary paragonimiasis acquired by eating raw crabs or by feeding juice of crushed crayfish for the treatment of measles in Korea. About 26.6 percent of people with paragonimiasis had cerebral paragonimiasis. Before bithionol therapy was introduced in 1962, neurosurgery was the only available treatment to control increased intracranial pressures, intractable epilepsy, paralysis and mental deterioration. Between 1958 to 1962, Bo Sung Sim operated on 24 patients of cerebral paragonimiasis. In two of them, he performed cerebral hemispherectomy to control intractable convulsions when he found diffuse cerebral paragonimiasis and cerebral atrophy at the

  8. Alleviation of hepatic oxidative stress by Chinese herbal medicine Yin-Chen-Hao-Tang in obese mice with steatosis.

    PubMed

    Lee, Tzung-Yan; Chang, Hen-Hong; Lo, Wen-Chai; Lin, Han-Chieh

    2010-06-01

    Obesity is associated with a complex systemic inflammatory state that has been implicated in the development of hepatic steatosis. This study was to test the efficacy of Yin-Chen-Hao-Tang (YCHT), an agent that improves hepatic triglyceride metabolism in its ability to modulate pathways implicated in hepatic steatosis. Mice were fed with high-fat diet for fifteen weeks. The therapeutic mechanism of YCHT likely enhanced adiponectin and endothelial progenitor cells, and up-regulation of peroxisome proliferator-activated receptor gamma might be responsible for fatty liver diseases. In addition, YCHT anti-oxidative stress effect might be associated with inhibition of hepatic free fatty acid concentrations and elevation of the glutathione levels in hepatic tissues. Furthermore, YCHT action mechanisms might promote senescence marker protein-30 metabolism that increase resistance to hepatic oxidative stress. These findings suggest a novel therapeutic approach for fatty liver progression in obesity mice.

  9. Landscape change and its effects on the wintering range of a lesser snow goose Chen caerulescens caerulescens population: A review

    USGS Publications Warehouse

    Robertson, Donna G.; Slack, R. Douglas

    1995-01-01

    The Texas coast has experienced considerable urban, industrial, and agricultural growth during the 20th Century. The region provides important wintering habitat to many avian species, including lesser snow geese Chen caerulescens caerulescens. This paper draws the biological and ecological fields into an historical perspective by examining available literature on the development of the upper Texas coast and range changes of lesser snow geese. Historically, lesser snow geese wintered in the coastal marshes, but expanded their range into the adjacent prairies in the mid-1900s. Winter range expansion was negatively affected by urban and industrial encroachment in the coastal marshes and positively influenced by agricultural development in the prairies, which increased dramatically during World War II. The lesser snow goose population flourished alongside some human-induced landscape alterations. However, projected declines in agriculture and increased urbanization of prairie and coastal marsh habitats may result in significant negative effects on the lesser snow goose population.

  10. An application of Chen system for secure chaotic communication based on extended Kalman filter and multi-shift cipher algorithm

    NASA Astrophysics Data System (ADS)

    Fallahi, Kia; Raoufi, Reza; Khoshbin, Hossein

    2008-07-01

    In recent years chaotic secure communication and chaos synchronization have received ever increasing attention. In this paper a chaotic communication method using extended Kalman filter is presented. The chaotic synchronization is implemented by EKF design in the presence of channel additive noise and processing noise. Encoding chaotic communication is used to achieve a satisfactory, typical secure communication scheme. In the proposed system, a multi-shift cipher algorithm is also used to enhance the security and the key cipher is chosen as one of the chaos states. The key estimate is employed to recover the primary data. To illustrate the effectiveness of the proposed scheme, a numerical example based on Chen dynamical system is presented and the results are compared to two other chaotic systems.

  11. The genetic legacy of Mother Goose--phylogeographic patterns of lesser snow goose Chen caerulescens caerulescens maternal lineages.

    PubMed

    Quinn, T W

    1992-08-01

    By using the polymerase chain reaction to amplify and sequence 178 bp of a rapidly evolving region of the mtDNA genome (segment I of the control region) from 81 individuals, approximately 11% of the variation present in the lesser snow goose Chen caerulescens caerulescens L. mitochondrial genome was surveyed. The 26 types of mtDNA detected formed two distinct mitochondrial clades that differ by an average of 6.7% and are distributed across the species range. Restriction analysis of amplified fragments was then used to assign the mtDNA of an additional 29 individuals to either of these clades. Within one major clade, sequence among mtDNAs was concordant with geographic location. Within the other major clade the degree of sequence divergence among haplotypes was lower and no consistent geographic structuring was evident. The two major clades presumably result from vicariant separation of lesser snow geese during the Pleistocene.

  12. Combine bivariate statistics analysis and multivariate statistics analysis to assess landslide susceptibility in Chen-Yu-Lan watershed, Nantou, Taiwan.

    NASA Astrophysics Data System (ADS)

    Ngan Nguyen, Thi To; Liu, Cheng-Chien

    2013-04-01

    How landslides occurred and which factors triggered and sped up landslide occurrences were usually asked by researchers in the past decades. Many investigations carried out in many places in the world to finding out methods that predict and prevent damages from landslides phenomena. Chen-Yu-Lan River watershed is reputed as a 'hot pot' of landslide researches in Taiwan by its complicated geological structures with the significant tectonic fault systems and steeply mountainous terrain. Beside annual high precipitation concentration and the abrupt slopes, some natural disaster, as typhoons (Sinlaku-2008, Kalmaegi-2008, and Marakot-2009) and earthquake (Chi-Chi earthquake-1999) are also the triggered factors cause landslides with serious damages in this place. This research expresses the quantitative approaches to generate landslide susceptible map for Chen-Yu-Lan watershed, a mountainous area in the central Taiwan. Landslide inventories data, which were detected from the Formosat-2 imageries for eight years from 2004 to 2011, were applied to carry out landslide susceptibility mapping. Bivariate statistics analysis and multivariate statistics analysis would be applied to calculate susceptible index of landslides. The weights of parameters were computed based on landslide data for eight years from 2004 to 2011. To validate effective levels of factors to landslide occurrences, this method built some multivariate algorithms and compared these results with real landslide occurrences. Besides this method, the historical data of landslides were also used to assess and classify landslide susceptibility levels. From long-term landslide data, relation between landslide susceptibility levels and landslide repetition was assigned. The results demonstrated differently effective levels of potential factors, such as, slope gradient, drainage density, lithology and land use to landslide phenomena. The results also showed logical relationship between weights and characteristics of

  13. Sea Bed Drilling Technology MARUM-MeBo: Overview on recent scientific drilling campaigns and technical developments

    NASA Astrophysics Data System (ADS)

    Freudenthal, Tim; Bergenthal, Markus; Bohrmann, Gerhard; Pape, Thomas; Kopf, Achim; Huhn-Frehers, Katrin; Gohl, Karsten; Wefer, Gerold

    2017-04-01

    The MARUM-MeBo (abbreviation for Meeresboden-Bohrgerät, the German expression for seafloor drill rig) is a robotic drilling system that is developed since 2004 at the MARUM Center for Marine Environmental Sciences at the University of Bremen in close cooperation with Bauer Maschinen GmbH and other industry partners. The MARUM-MeBo drill rigs can be deployed from multipurpose research vessel like, RV MARIA S. MERIAN, RV METEOR, RV SONNE and RV POLARSTERN and are used for getting long cores both in soft sediments as well as hard rocks in the deep sea. The first generation drill rig, the MARUM-MeBo70 is dedicated for a drilling depth of more than 70 m (Freudenthal and Wefer, 2013). Between 2005 and 2016 it was deployed on 17 research expeditions and drilled about 3 km into different types of geology including carbonate and crystalline rocks, gas hydrates, glacial tills, sands and gravel, glacial till and hemipelagic mud with an average recovery rate of about 70 %. We used the development and operational experiences of MARUM-MeBo70 for the development of a second generation drill rig MARUM-MeBo200. This drill rig is dedicated for conducting core drilling down to 200 m below sea floor. After successful sea trials in the North Sea in October 2014 the MeBo200 was used on a scientific expedition on the research vessel RV SONNE (SO247) in March/April 2016. During 12 deployments we drilled altogether 514 m in hemipelagic sediments with volcanic ashes as well as in muddy and sandy slide deposits off New Zealand. The average core recovery was about 54%. The maximum drilling depth was 105 m below sea floor. Developments for the MeBo drilling technology include the development of a pressure core barrel that was successfully deployed on two research expeditions so far. Bore hole logging adds to the coring capacity. Several autonomous logging probes have been developed in the last years for a deployment with MeBo in the logging while tripping mode - a sonic probe measuring in

  14. BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge

    PubMed Central

    Crump, Ryan W.; Doronin, Konstantin; Hembrador, Edguardo; Pompilio, Daniela; Tebaldi, Giulia; Estep, Ryan D.; Wong, Scott W.; Buller, Mark R.; Donofrio, Gaetano

    2015-01-01

    Monkeypox virus (MPXV) is the etiological agent of human (MPX). It is an emerging orthopoxvirus zoonosis in the tropical rain forest of Africa and is endemic in the Congo-basin and sporadic in West Africa; it remains a tropical neglected disease of persons in impoverished rural areas. Interaction of the human population with wildlife increases human infection with MPX virus (MPXV), and infection from human to human is possible. Smallpox vaccination provides good cross-protection against MPX; however, the vaccination campaign ended in Africa in 1980, meaning that a large proportion of the population is currently unprotected against MPXV infection. Disease control hinges on deterring zoonotic exposure to the virus and, barring that, interrupting person-to-person spread. However, there are no FDA-approved therapies against MPX, and current vaccines are limited due to safety concerns. For this reason, new studies on pathogenesis, prophylaxis and therapeutics are still of great interest, not only for the scientific community but also for the governments concerned that MPXV could be used as a bioterror agent. In the present study, a new vaccination strategy approach based on three recombinant bovine herpesvirus 4 (BoHV-4) vectors, each expressing different MPXV glycoproteins, A29L, M1R and B6R were investigated in terms of protection from a lethal MPXV challenge in STAT1 knockout mice. BoHV-4-A-CMV-A29LgD106ΔTK, BoHV-4-A-EF1α-M1RgD106ΔTK and BoHV-4-A-EF1α-B6RgD106ΔTK were successfully constructed by recombineering, and their capacity to express their transgene was demonstrated. A small challenge study was performed, and all three recombinant BoHV-4 appeared safe (no weight-loss or obvious adverse events) following intraperitoneal administration. Further, BoHV-4-A-EF1α-M1RgD106ΔTK alone or in combination with BoHV-4-A-CMV-A29LgD106ΔTK and BoHV-4-A-EF1α-B6RgD106ΔTK, was shown to be able to protect, 100% alone and 80% in combination, STAT1(-/-) mice against

  15. Somatic embryogenesis and enhanced shoot organogenesis in Metabriggsia ovalifolia W. T. Wang

    PubMed Central

    Ouyang, Yao; Chen, Yulu; Lü, Jinfeng; Teixeira da Silva, Jaime A.; Zhang, Xinhua; Ma, Guohua

    2016-01-01

    An efficient protocol providing a dual regeneration pathway via direct shoot organogenesis and somatic embryogenesis for an endangered species, Metabriggsia ovalifolia W. T. Wang, was established from leaf explants. When applied at 2.5 μM, the cytokinins 6-benzyladenine (BA) or thidiazuron (TDZ) and the auxins indole-3-butyric acid (IBA), α-naphthaleneacetic acid (NAA) and indole-3-acetic acid (IAA) could induce shoots when on basal Murashige and Skoog (MS) medium. BA and TDZ could induce more adventitious shoots (19.1 and 31.2/explant, respectively) than NAA (4.6/explant), IBA (5.7/explant) or IAA (6.4/explant). BA and TDZ at 5–10 μM could induce both shoots and somatic embryos. A higher concentration of TDZ (25 μM) induced only somatic embryos (39.8/explant). The same concentration of BA induced both adventitious shoots (23.6/explant) and somatic embryos (9.7/explant). Thus, somatic embryogenesis in this plant needs a high cytokinin concentration (BA; TDZ), as evidenced by histology. Somatic embryos germinated easily when left on the same media, but formed adventitious roots in two weeks on MS supplemented with 0.5 μM NAA, 0.5 μM IBA and 0.1% activated charcoal. Over 93% of plantlets survived following acclimatization and transfer to a mixture of sand and vermiculite (1:1, v/v) in trays. PMID:27090564

  16. Somatic embryogenesis and enhanced shoot organogenesis in Metabriggsia ovalifolia W. T. Wang.

    PubMed

    Ouyang, Yao; Chen, Yulu; Lü, Jinfeng; Teixeira da Silva, Jaime A; Zhang, Xinhua; Ma, Guohua

    2016-04-19

    An efficient protocol providing a dual regeneration pathway via direct shoot organogenesis and somatic embryogenesis for an endangered species, Metabriggsia ovalifolia W. T. Wang, was established from leaf explants. When applied at 2.5 μM, the cytokinins 6-benzyladenine (BA) or thidiazuron (TDZ) and the auxins indole-3-butyric acid (IBA), α-naphthaleneacetic acid (NAA) and indole-3-acetic acid (IAA) could induce shoots when on basal Murashige and Skoog (MS) medium. BA and TDZ could induce more adventitious shoots (19.1 and 31.2/explant, respectively) than NAA (4.6/explant), IBA (5.7/explant) or IAA (6.4/explant). BA and TDZ at 5-10 μM could induce both shoots and somatic embryos. A higher concentration of TDZ (25 μM) induced only somatic embryos (39.8/explant). The same concentration of BA induced both adventitious shoots (23.6/explant) and somatic embryos (9.7/explant). Thus, somatic embryogenesis in this plant needs a high cytokinin concentration (BA; TDZ), as evidenced by histology. Somatic embryos germinated easily when left on the same media, but formed adventitious roots in two weeks on MS supplemented with 0.5 μM NAA, 0.5 μM IBA and 0.1% activated charcoal. Over 93% of plantlets survived following acclimatization and transfer to a mixture of sand and vermiculite (1:1, v/v) in trays.

  17. Temperature-dependent phase transition of ferroelectric perovskites: A Wang-Landau-DFT approach

    NASA Astrophysics Data System (ADS)

    Yuk, Simuck; Li, Ying Wai; Eisenbach, Markus; Cooper, Valentino

    Since the discovery of ferroelectricity in perovskite oxides, considerable efforts have been devoted to understanding their phase transition behaviors in terms of temperature, pressure, and composition. Such materials have regularly been used in transducer and actuator applications. As our first step to make accurate predictions of the crystal phases of more complex oxides such as Pb(ZrxTi1-x) O3, we have used the Wang-Landau (WL) algorithm and density functional theory (DFT) to examine the temperature-dependent phase transition of PbTiO3, BaTiO3, and KNbO3. DFT was employed to evaluate the energetics of important crystal-structure candidates, which were later used as the input for WL algorithm. In addition, we examine how the choice of exchange-correlation functionals affects our predictions of the relevant phase transition temperatures. Research supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Science and Engineering Division and the Office of Science Early Career Research Program (V.R.C.) and used resources at NERSC and OLCF.

  18. Wang-Landau sampling of the interplay between surface adsorption and folding of HP lattice proteins

    SciTech Connect

    Li, Ying Wai; Wuest, Thomas; Landau, David P

    2014-01-01

    Generic features associated with the adsorption of proteins on solid surfaces are reviewed within the framework of the hydrophobic-polar (HP) lattice protein model. The thermodynamic behavior and structural properties of various HP protein sequences interacting with attractive surfaces have been studied using extensive Wang-Landau sampling with different types of surfaces, each of which attracts either: all monomers, only hydrophobic (H) monomers, or only polar (P) monomers, respectively. Consequently, different types of folding behavior occur for varied surface strengths. Analysis of the combined patterns of various structural observables, e.g., the derivatives of the numbers of interaction contacts, together with the specific heat, leads to the identification of fundamental categories of folding and transition hierarchies. We also inferred a connection between the transition categories and the relative surface strengths, i.e., the ratios of the surface attractive strengths to the intra-chain attraction among H monomers. We thus believe that the folding hierarchies and identification scheme are generic for different HP sequences interacting with attractive surfaces, regardless of the chain length, sequence, or surface attraction.

  19. Enhanced von Weizsäcker Wang-Govind-Carter kinetic energy density functional for semiconductors

    NASA Astrophysics Data System (ADS)

    Shin, Ilgyou; Carter, Emily A.

    2014-05-01

    We propose a new form of orbital-free (OF) kinetic energy density functional (KEDF) for semiconductors that is based on the Wang-Govind-Carter (WGC99) nonlocal KEDF. We enhance within the latter the semi-local von Weizsäcker KEDF term, which is exact for a single orbital. The enhancement factor we introduce is related to the extent to which the electron density is localized. The accuracy of the new KEDF is benchmarked against Kohn-Sham density functional theory (KSDFT) by comparing predicted energy differences between phases, equilibrium volumes, and bulk moduli for various semiconductors, along with metal-insulator phase transition pressures. We also compare point defect and (100) surface energies in silicon for a broad test of its applicability. This new KEDF accurately reproduces the exact non-interacting kinetic energy of KSDFT with only one additional adjustable parameter beyond the three parameters in the WGC99 KEDF; it exhibits good transferability between semiconducting to metallic silicon phases and between various III-V semiconductors without parameter adjustment. Overall, this KEDF is more accurate than previously proposed OF KEDFs (e.g., the Huang-Carter (HC) KEDF) for semiconductors, while the computational efficiency remains at the level of the WGC99 KEDF (several hundred times faster than the HC KEDF). This accurate, fast, and transferable new KEDF holds considerable promise for large-scale OFDFT simulations of metallic through semiconducting materials.

  20. Enhanced von Weizsäcker Wang-Govind-Carter kinetic energy density functional for semiconductors.

    PubMed

    Shin, Ilgyou; Carter, Emily A

    2014-05-14

    We propose a new form of orbital-free (OF) kinetic energy density functional (KEDF) for semiconductors that is based on the Wang-Govind-Carter (WGC99) nonlocal KEDF. We enhance within the latter the semi-local von Weizsäcker KEDF term, which is exact for a single orbital. The enhancement factor we introduce is related to the extent to which the electron density is localized. The accuracy of the new KEDF is benchmarked against Kohn-Sham density functional theory (KSDFT) by comparing predicted energy differences between phases, equilibrium volumes, and bulk moduli for various semiconductors, along with metal-insulator phase transition pressures. We also compare point defect and (100) surface energies in silicon for a broad test of its applicability. This new KEDF accurately reproduces the exact non-interacting kinetic energy of KSDFT with only one additional adjustable parameter beyond the three parameters in the WGC99 KEDF; it exhibits good transferability between semiconducting to metallic silicon phases and between various III-V semiconductors without parameter adjustment. Overall, this KEDF is more accurate than previously proposed OF KEDFs (e.g., the Huang-Carter (HC) KEDF) for semiconductors, while the computational efficiency remains at the level of the WGC99 KEDF (several hundred times faster than the HC KEDF). This accurate, fast, and transferable new KEDF holds considerable promise for large-scale OFDFT simulations of metallic through semiconducting materials.

  1. Validation of Community Models: 2. Development of a Baseline, Using the Wang-Sheeley-Arge Model

    NASA Technical Reports Server (NTRS)

    MacNeice, Peter

    2009-01-01

    This paper is the second in a series providing independent validation of community models of the outer corona and inner heliosphere. Here I present a comprehensive validation of the Wang-Sheeley-Arge (WSA) model. These results will serve as a baseline against which to compare the next generation of comparable forecasting models. The WSA model is used by a number of agencies to predict Solar wind conditions at Earth up to 4 days into the future. Given its importance to both the research and forecasting communities, it is essential that its performance be measured systematically and independently. I offer just such an independent and systematic validation. I report skill scores for the model's predictions of wind speed and interplanetary magnetic field (IMF) polarity for a large set of Carrington rotations. The model was run in all its routinely used configurations. It ingests synoptic line of sight magnetograms. For this study I generated model results for monthly magnetograms from multiple observatories, spanning the Carrington rotation range from 1650 to 2074. I compare the influence of the different magnetogram sources and performance at quiet and active times. I also consider the ability of the WSA model to forecast both sharp transitions in wind speed from slow to fast wind and reversals in the polarity of the radial component of the IMF. These results will serve as a baseline against which to compare future versions of the model as well as the current and future generation of magnetohydrodynamic models under development for forecasting use.

  2. Phase transitions of a single polymer chain: A Wang-Landau simulation study.

    PubMed

    Taylor, Mark P; Paul, Wolfgang; Binder, Kurt

    2009-09-21

    A single flexible homopolymer chain can assume a variety of conformations which can be broadly classified as expanded coil, collapsed globule, and compact crystallite. Here we study transitions between these conformational states for an interaction-site polymer chain comprised of N=128 square-well-sphere monomers with hard-sphere diameter sigma and square-well diameter lambdasigma. Wang-Landau sampling with bond-rebridging Monte Carlo moves is used to compute the density of states for this chain and both canonical and microcanonical analyses are used to identify and characterize phase transitions in this finite size system. The temperature-interaction range (i.e., T-lambda) phase diagram is constructed for lambda1.06 these two states are separated by an intervening collapsed globule phase and thus, with decreasing temperature a chain undergoes a continuous coil-globule (collapse) transition followed by a discontinuous globule-crystal (freezing) transition. For well diameters lambda<1.06 the collapse transition is pre-empted by the freezing transition and thus there is a direct first-order coil-crystal phase transition. These results confirm the recent prediction, based on a lattice polymer model, that a collapsed globule state is unstable with respect to a solid phase for flexible polymers with sufficiently short-range monomer-monomer interactions.

  3. Generic transition hierarchies of lattice HP protein adsorption: A Wang-Landau study

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Landau, D. P.; Wüst, T.

    2012-02-01

    We have applied Wang-Landau sampling with appropriate trial movesootnotetextT. W"ust and D. P. Landau, Phy. Rev. Lett. 102, 178101 (2009). to investigate the thermodynamics and structural properties of the HP lattice protein modelootnotetextK. A. Dill, Biochemistry 24, 1501 (1985). interacting with an attractive substrate. The conformational ``phase transitions'' of several benchmark HP sequences have been identified by a comprehensive canonical analysis of the specific heat and structural observables, e. g. radius of gyration and thermal derivatives of number of surface contacts. Three major ``transitions'': adsorption, hydrophobic core formation, and ``flattening'' of adsorbed structures, are observed. Depending on the surface attractive strength relative to the intra-protein attraction among the H monomers, these processes take place in a different order upon cooling. We identify a small number of generic categories that are sufficient to classify the folding hierarchies for different HP chains consisting of assorted sequences and chain lengths, regardless of the monomer type that the surface attracts. We thus believe that this classification scheme is generally applicable to lattice protein adsorption problems.

  4. Thermodynamics and structural properties of a confined HP protein determined by Wang-Landau simulation

    NASA Astrophysics Data System (ADS)

    Pattanasiri, Busara; Li, Ying Wai; Landau, David P.; Wüst, Thomas; Triampo, Wannapong

    2013-08-01

    Understanding protein folding confined by surfaces is important for both biological sciences and the development of nanomaterials. In this work, we study the properties of a confined HP model protein by three different types of surfaces, namely, surfaces that attract: (a) all monomers; (b) only P monomers; and (c) only H monomers. The thermodynamic and structural quantities, such as the specific heat, number of surface contacts, and number of hydrophobic pairs, are obtained by using Wang-Landau sampling. The conformational "transitions", specifically, the debridging process and hydrophobic core formation, can be identified based on an analysis of these quantities. We found that these transitions take place at different temperatures, and the ground state configurations show variations in structural properties when different surface type is used. These scenarios are confirmed by snapshots of typical states of the systems. From our study, we conclude that the thermodynamics of these transitions and the structural changes depend on the combined actions of both the composition of the H monomers and the P monomers in the HP chain and the surface types.

  5. Application of the Wang-Landau algorithm to the dimerization of glycophorin A

    NASA Astrophysics Data System (ADS)

    Gervais, Claire; Wüst, Thomas; Landau, D. P.; Xu, Ying

    2009-06-01

    A two-step Monte Carlo procedure is developed to investigate the dimerization process of the homodimer glycophorin A. In the first step, the energy density of states of the system is estimated by the Wang-Landau algorithm. In the second step, a production run is performed during which various energetical and structural observables are sampled to provide insight into the thermodynamics of the system. All seven residues LIxxGVxxGVxxT constituting the contact interface play a dominating role in the dimerization, however at different stages of the process. The leucine motif and to some extent the GxxxG motif are involved at the very beginning of the dimerization when the two helices come into contact, ensuring an interface already similar to the native one. At a lower temperature, the threonine motif stabilizes by hydrogen bonding the dimer, which finally converges toward its native state at around 300 K. The power and flexibility of the procedure employed here makes it an interesting alternative to other Monte Carlo methods for the study of similar protein systems.

  6. Nonconvergence of the Wang-Landau algorithms with multiple random walkers.

    PubMed

    Belardinelli, R E; Pereyra, V D

    2016-05-01

    This paper discusses some convergence properties in the entropic sampling Monte Carlo methods with multiple random walkers, particularly in the Wang-Landau (WL) and 1/t algorithms. The classical algorithms are modified by the use of m-independent random walkers in the energy landscape to calculate the density of states (DOS). The Ising model is used to show the convergence properties in the calculation of the DOS, as well as the critical temperature, while the calculation of the number π by multiple dimensional integration is used in the continuum approximation. In each case, the error is obtained separately for each walker at a fixed time, t; then, the average over m walkers is performed. It is observed that the error goes as 1/sqrt[m]. However, if the number of walkers increases above a certain critical value m>m_{x}, the error reaches a constant value (i.e., it saturates). This occurs for both algorithms; however, it is shown that for a given system, the 1/t algorithm is more efficient and accurate than the similar version of the WL algorithm. It follows that it makes no sense to increase the number of walkers above a critical value m_{x}, since it does not reduce the error in the calculation. Therefore, the number of walkers does not guarantee convergence.

  7. Identification of hyperhalogens in Ag(n)(BO2)(m) (n = 1-3, m = 1-2) clusters: anion photoelectron spectroscopy and density functional calculations.

    PubMed

    Kong, Xiang-Yu; Xu, Hong-Guang; Koirala, Pratik; Zheng, Wei-Jun; Kandalam, Anil K; Jena, Puru

    2014-12-21

    The electronic and structural properties of neutral and anionic Agn(BO2)m (n = 1-3, m = 1-2) clusters are investigated by using mass-selected anion photoelectron spectroscopy and density functional theory calculations. Agreement between the measured and calculated vertical detachment energies (VDEs) allows us to validate the equilibrium geometries of [Agn(BO2)m](-) clusters obtained from theory. The ground state structures of anionic Ag2(BO2) and Agn(BO2)2 (n = 1-3) clusters are found to be very different from those of their neutral counterparts. The structures of anionic clusters are chain-like while those of the neutral clusters are closed-rings. The presence of multiple isomers for [Ag2(BO2)2](-) and [Ag3(BO2)2](-) in the cluster beam has also been confirmed. Several of these clusters are found to be hyperhalogens.

  8. Identification of BoLA-DRB3.2 alleles in Korean native cattle (Hanwoo) and Holstein populations using a next generation sequencer.

    PubMed

    Lee, Bo-Young; Hur, Tai-Young; Jung, Young-Hun; Kim, Heebal

    2012-08-01

    Bovine leucocyte antigen (encoded by BoLA) has been widely studied to identify the association with many traits related to immunity. Exon2 of BoLA-DRB3 is extremely polymorphic, and more than 100 alleles have been identified. We investigated polymorphisms of BoLA-DRB3.2 in Korean native cattle and Holstein populations using a next generation sequencer of the GS-FLX Titanium system. We found 38 alleles including 11 new alleles (BoLA-DRB3*1303, *4702, *7101, *7501, *7201, *7301, *7601, *1104, *7701, *7401 and *50021) in Hanwoo, and nine alleles including one new allele (BoLA-DRB3*7601) in Holstein. The 454 sequencing method is a promising alternative technology for high throughput genotyping of BoLA-DRB3.2 because of its technical advantages that allow it to overcome the disadvantages of sequence-based typing methods.

  9. Evaluation of a position sensitive neutron detector based on Li6Gd(BO3)3 scintillator

    NASA Astrophysics Data System (ADS)

    Schooneveld, Erik M.; Czirr, J. B.; McKnight, Thomas K.; Rhodes, Nigel J.; Ibberson, R. M.

    2002-11-01

    As a result of the ever increasing demand for higher neutron flux, future neutron scintillator detectors will require faster scintillators with a high light yield and low gamma sensitivity. Initial measurements with single element prototypes demonstrated that the new lithium gadolinium borate (LiGdBO) scintillator, using 6Li as the neutron absorber, was a promising candidate. As a result of this work, a full size position sensitive detector module has been made consisting of 120 LiGdBO elements. This module was installed on the High Resolution Powder Diffractometer (HRPD) beam line at ISIS for evaluation. The LiGdBO detector has been constructed with the same geometry and theoretically the same neutron absorption efficiency as the existing HRPD ZnS scintillator detector modules. In this way it was possible to make a more exact comparison of the relative detector performances. Measurements have shown that the neutron energy resolution and detection efficiency of both types of detector are identical. Gamma sensitivity and quiet count rate are somewhat higher for the LiGdBO than the ZnS scintillator detector, but still at an acceptable level for many applications. The short decay time of the LiGdBO scintillator has enhanced the count-rate capability of the detector by an order of magnitude. These measurements show that realistic large area position sensitive neutron detectors can be fabricated with LiGdBO scintillator using an optical fibre readout. LiGdBO is thus a promising scintillator for future detectors at the new high flux facilities currently under construction.

  10. Alpha-Latrotoxin Rescues SNAP-25 from BoNT/A-Mediated Proteolysis in Embryonic Stem Cell-Derived Neurons

    PubMed Central

    Mesngon, Mariano; McNutt, Patrick

    2011-01-01

    The botulinum neurotoxins (BoNTs) exhibit zinc-dependent proteolytic activity against members of the core synaptic membrane fusion complex, preventing neurotransmitter release and resulting in neuromuscular paralysis. No pharmacologic therapies have been identified that clinically relieve botulinum poisoning. The black widow spider venom α-latrotoxin (LTX) has the potential to attenuate the severity or duration of BoNT-induced paralysis in neurons via the induction of synaptic degeneration and remodeling. The potential for LTX to antagonize botulinum poisoning was evaluated in embryonic stem cell-derived neurons (ESNs), using a novel screening assay designed around the kinetics of BoNT/A activation. Exposure of ESNs to 400 pM LTX for 6.5 or 13 min resulted in the nearly complete restoration of uncleaved SNAP-25 within 48 h, whereas treatment with 60 mM K+ had no effect. Time-lapse imaging demonstrated that LTX treatment caused a profound increase in Ca2+ influx and evidence of excitotoxicity, though ESNs remained viable 48 h after LTX treatment. This is the first instance of a cell-based treatment that has shown the ability to eliminate BoNT activity. These data suggest that LTX treatment may provide the basis for a new class of therapeutic approach to BoNT intoxication and may contribute to an improved understanding of long-term mechanisms of BoNT intoxication and recovery. They further demonstrate that ESNs are a novel, responsive and biologically relevant model for LTX research and BoNT therapeutic drug discovery. PMID:22069721

  11. A hydrophobic hole transporting system to improve moisture stability of perovskite solar cells (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Xiao, Lixin

    2016-09-01

    Non-ion additive hole-transporting material (HTM) of hydrophobic oligothiophene derivative named DR3TBDTT and triphenylamine derivative of N,N'-di(3-methylphenyl)-N,N-diphenyl-4,4-diaminobiphenyl (TPD) were used for the organic-inorganic hybrid perovskite solar cells. The power conversion efficiency (PCE) was comparable to the device using Li-TFSI doped spiro-MeOTAD. Moreover, the PCE decreases by only 10% after approximately 1000 h without encapsulation, which suggests an alternative method to improve the stability of perovskite solar cells[1-3 ]. Figure 1. Schematic illustration of the energy diagram of the device without lithium salts REFERENCES [1] Zheng, L.; Ma, Y.; Chu, S.; Wang, S.; Qu, B.; Xiao, L.; Chen, Z.;Gong, Q.; Wu, Z.; Hou, X. Nanoscale 6, 8171-8176 (2014). [2] Zheng Lingling, Chung Yao-Hsien, Ma Yingzhuang, Zhang Lipei, Xiao Lixin, Chen Zhijian, Wang Shufeng, Qu Bo and Gong Qihuang, Chem. Commun. 50, 11196-11199 (2014). [3] Ma Yingzhuang, Chung Yao-Hsien, Zheng Lingling, Zhang Danfei, Yu Xiao, Xiao Lixin, Chen Zhijian, Wang Shufeng, Qu Bo, Gong Qihuang, and Zou Dechun, ACS Appl. Mater. Interfaces 7 (12), 6406-6411 (2015)

  12. Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

    PubMed Central

    Kalb, Suzanne R.; Lou, Jianlong; Garcia-Rodriguez, Consuelo; Geren, Isin N.; Smith, Theresa J.; Moura, Hercules; Marks, James D.; Smith, Leonard A.; Pirkle, James L.; Barr, John R.

    2009-01-01

    Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing death or respiratory failure leading to long-term intensive care. Treatment includes serotype-specific antitoxins, which must be administered early in the course of the intoxication. Rapidly determining human exposure to BoNT is an important public health goal. In previous work, our laboratory focused on developing Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating BoNT/A–G serotypes in buffer and BoNT/A, /B, /E, and /F in clinical samples. We have previously reported the effectiveness of antibody-capture to purify and concentrate BoNTs from complex matrices, such as clinical samples. Because some antibodies inhibit or neutralize the activity of BoNT, the choice of antibody with which to extract the toxin is critical. In this work, we evaluated a panel of 16 anti-BoNT/A monoclonal antibodies (mAbs) for their ability to inhibit the in vitro activity of BoNT/A1, /A2, and /A3 complex as well as the recombinant LC of A1. We also evaluated the same antibody panel for the ability to extract BoNT/A1, /A2, and /A3. Among the mAbs, there were significant differences in extraction efficiency, ability to extract BoNT/A subtypes, and inhibitory effect on BoNT catalytic activity. The mAbs binding the C-terminal portion of the BoNT/A heavy chain had optimal properties for use in the Endopep-MS assay. PMID:19399171

  13. Evidence for cattle major histocompatibility complex (BoLA) class II DQA1 gene heterozygote advantage against clinical mastitis caused by Streptococci and Escherichia species.

    PubMed

    Takeshima, S; Matsumoto, Y; Chen, J; Yoshida, T; Mukoyama, H; Aida, Y

    2008-12-01

    Mastitis is an inflammatory response of the mammary gland to irritation, injury, or infectious agents and is a major problem in the dairy industry. We genotyped bovine major histocompatibility complex (BoLA)-DRB3 and BoLA-DQA1 genes in 120 Holstein cattle with clinical mastitis and 85 randomly selected Holstein cattle in Japan by polymerase chain reaction-sequence-based typing. The mastitis cattle were divided into four groups according to the bacterial species that caused the mastitis (Staphylococcus aureus, Streptococci, Escherichia, and coagulase-negative staphylococci). The BoLA-DRB3 and BoLA-DQA1 heterozygosity of each group was compared with that of the control cattle, while the expected heterozygosities based on Hardy-Weinberg proportions and the observed heterozygosities for each locus were compared for each group. The Escherichia-induced and Streptococci-induced mastitis groups showed significant differences between their expected and observed heterozygosities with regard to their BoLA-DQA1 genes. No differences were observed for any group with regard to the BoLA-DRB3 genes. We then found that two BoLA-DQA1 alleles promoted susceptibility to Streptococci-induced mastitis, namely BoLA-DQA1*0101 and BoLA-DQA1*10012 and that the homozygous BoLA-DQA1*0101/0101 and BoLA-DQA1*10011/10011 genotypes promoted susceptibility to mastitis caused by Streptococci and Escherichia, respectively. This is the first report showing that heterozygosity of the BoLA-DQA1 gene is associated with resistance to mastitis progression.

  14. Monte Carlo and Molecular Dynamics in the Multicanonical Ensemble: Connections between Wang-Landau Sampling and Metadynamics

    NASA Astrophysics Data System (ADS)

    Vogel, Thomas; Perez, Danny; Junghans, Christoph

    2014-03-01

    We show direct formal relationships between the Wang-Landau iteration [PRL 86, 2050 (2001)], metadynamics [PNAS 99, 12562 (2002)] and statistical temperature molecular dynamics [PRL 97, 050601 (2006)], the major Monte Carlo and molecular dynamics work horses for sampling from a generalized, multicanonical ensemble. We aim at helping to consolidate the developments in the different areas by indicating how methodological advancements can be transferred in a straightforward way, avoiding the parallel, largely independent, developments tracks observed in the past.

  15. Influence of yield on in vitro accumulation of aflatoxins in pecan (Carya illinoensis (Wang.) K. Koch) nutmeats.

    PubMed Central

    McMeans, J L

    1983-01-01

    Pecans were harvested from trees (Carya illinoensis (Wang.) K. Koch) in November of 1977 through 1979. Kernel meals from high-, medium-, and low-yielding trees were inoculated with a spore suspension of Aspergillus parasiticus and incubated for 7 days at 25 degrees C. Significant differences in aflatoxin accumulation were found among the three substrates, with a direct correlation between high aflatoxin concentration and tree yield. PMID:6830223

  16. Influence of yield on in vitro accumulation of aflatoxins in pecan (Carya illinoensis (Wang.) K. Koch) nutmeats.

    PubMed

    McMeans, J L

    1983-02-01

    Pecans were harvested from trees (Carya illinoensis (Wang.) K. Koch) in November of 1977 through 1979. Kernel meals from high-, medium-, and low-yielding trees were inoculated with a spore suspension of Aspergillus parasiticus and incubated for 7 days at 25 degrees C. Significant differences in aflatoxin accumulation were found among the three substrates, with a direct correlation between high aflatoxin concentration and tree yield.

  17. Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C

    PubMed Central

    Benoit, Roger M.; Schärer, Martin A.; Wieser, Mara M.; Li, Xiaodan; Frey, Daniel; Kammerer, Richard A.

    2017-01-01

    A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with the luminal domain (LD) of its neuronal receptor SV2C revealed only few specific side-chain – side-chain interactions that are important for binding. Notably, two BoNT/A1 residues, Arg 1156 and Arg 1294, that are crucial for the interaction with SV2, are not conserved among subtypes. Because it has been suggested that differential receptor binding of subtypes might explain their differences in biological activity, we determined the crystal structure of BoNT/A2-HC in complex with SV2C-LD. Although only few side-chain interactions are conserved between the two BoNT/A subtypes, the overall binding mode of subtypes A1 and A2 is virtually identical. In the BoNT/A2-HC – SV2C complex structure, a missing cation-π stacking is compensated for by an additional salt bridge and an anion-π stacking interaction, which explains why the binding of BoNT/A subtypes to SV2C tolerates variable side chains. These findings suggest that motif extensions and a shallow binding cleft in BoNT/A-HC contribute to binding specificity. PMID:28252640

  18. Magnetic properties of monoclinic lanthanide metaborates, Ln(BO2)3, Ln  =  Pr, Nd, Gd, Tb

    NASA Astrophysics Data System (ADS)

    Mukherjee, P.; Suard, E.; Dutton, S. E.

    2017-10-01

    The bulk magnetic properties of the lanthanide metaborates, Ln(BO2)3, Ln  =  Pr, Nd, Gd, Tb are studied using magnetic susceptibility, heat capacity and isothermal magnetisation measurements. They are found to crystallise in a monoclinic structure containing chains of magnetic Ln 3+ and could therefore exhibit features of low-dimensional magnetism and frustration. Pr(BO2)3 is found to have a non-magnetic singlet ground state. No magnetic ordering is observed down to 0.4 K for Nd(BO2)3. Gd(BO2)3 exhibits a sharp magnetic transition at 1.1 K, corresponding to 3D magnetic ordering. Tb(BO2)3 shows two magnetic ordering features at 1.05 K and 1.95 K. A magnetisation plateau at a third of the saturation magnetisation is seen at 2 K for both Nd(BO2)3 and Tb(BO2)3, which persists in an applied field of 14 T. This is proposed to be a signature of quasi 1D behaviour in Nd(BO2)3 and Tb(BO2)3.

  19. A chemical confirmation of the faint Boötes II dwarf spheroidal galaxy

    SciTech Connect

    Koch, Andreas; Rich, R. Michael

    2014-10-10

    We present a chemical abundance study of the brightest confirmed member star of the ultra-faint dwarf galaxy Boötes II from Keck/HIRES high-resolution spectroscopy at moderate signal-to-noise ratios. At [Fe/H] = –2.93 ± 0.03(stat.) ± 0.17(sys.), this star chemically resembles metal-poor halo field stars and the signatures of other faint dwarf spheroidal galaxies at the same metallicities in that it shows enhanced [α/Fe] ratios, Solar Fe-peak element abundances, and low upper limits on the neutron-capture element Ba. Moreover, this star shows no chemical peculiarities in any of the eight elements we were able to measure. This implies that the chemical outliers found in other systems remain outliers pertaining to the unusual enrichment histories of the respective environments, while Boo II appears to have experienced an enrichment history typical of its very low mass. We also re-calibrated previous measurements of the galaxy's metallicity from the calcium triplet (CaT) and find a much lower value than reported before. The resulting broad metallicity spread, in excess of one dex, the very metal-poor mean, and the chemical abundance patterns of the present star imply that Boötes II is a low-mass, old, metal-poor dwarf galaxy and not an overdensity associated with the Sagittarius Stream as has been previously suggested based on its sky position and kinematics. The low, mean CaT metallicity of –2.7 dex falls right on the luminosity-metallicity relation delineated over four orders of magnitude from the more luminous to the faintest galaxies. Thus Boötes II's chemical enrichment appears representative of the galaxy's original mass, while tidal stripping and other mass loss mechanisms were probably not significant as for other low-mass satellites.

  20. BoLA-DRB3 gene polymorphism and FMD resistance or susceptibility in Wanbei cattle.

    PubMed

    Lei, Wei; Liang, Qinglong; Jing, Luo; Wang, Chengmin; Wu, Xiaobing; He, Hongxuan

    2012-09-01

    For the further characterization of foot-and-mouth disease virus (FMDV)-induced foot-and-mouth disease, we investigated the association between polymorphism of BoLA-DRB3 gene and FMD resistance/susceptibility of Wanbei cattle challenged with FMDV. One hundred cattle were challenged with FMDV and exon 2 of BoLA-DRB3 genes was amplified by hemi-nested polymerase chain reaction from asymptomatic animals and from animals with FMD. PCR products were characterized by the RFLP technique using restriction enzymes Hae III. The results revealed extensive polymorphisms, 6 RFLP patterns were identified. By analyzing alleles and genotypic frequencies between healthy and infection with FMD cattle, we found that allele Hae III A was associated with susceptibility to FMD in Wanbei cattle (P < 0.05), whereas Hae III C was associated with resistance to FMD (P < 0.01) and may have a strong protective effect against FMD. Hae IIICC and Hae III BC genotype were associated with resistance to FMD (P < 0.01). By contrast, Hae III AA genotype was associated with susceptibility to FMD (P < 0.01). Sequence analysis show that 89 amino acids were translated in exon 2 of BoLA-DRB3 and 13.70 % of nucleotide mutated, which resulted in 14.61 % of amino acid change. One PKC, one Tyr and one CAMP phosphorylation were increased; the hydrophobicity and secondary structure of proteins produced change after amino acid substitution. These results revealed that Wanbei cattle had the ability of resistance to disease by mutation which result changes of the protein structure to perform the regulation of the cell using different signaling pathways in the long process of choice evolution.

  1. Evidence of positive selection towards Zebuine haplotypes in the BoLA region of Brangus cattle.

    PubMed

    Goszczynski, D E; Corbi-Botto, C M; Durand, H M; Rogberg-Muñoz, A; Munilla, S; Peral-Garcia, P; Cantet, R J C; Giovambattista, G

    2017-07-14

    The Brangus breed was developed to combine the superior characteristics of both of its founder breeds, Angus and Brahman. It combines the high adaptability to tropical and subtropical environments, disease resistance, and overall hardiness of Zebu cattle with the reproductive potential and carcass quality of Angus. It is known that the major histocompatibility complex (MHC, also known as bovine leucocyte antigen: BoLA), located on chromosome 23, encodes several genes involved in the adaptive immune response and may be responsible for adaptation to harsh environments. The objective of this work was to evaluate whether the local breed ancestry percentages in the BoLA locus of a Brangus population diverged from the estimated genome-wide proportions and to identify signatures of positive selection in this genomic region. For this, 167 animals (100 Brangus, 45 Angus and 22 Brahman) were genotyped using a high-density single nucleotide polymorphism array. The local ancestry analysis showed that more than half of the haplotypes (55.0%) shared a Brahman origin. This value was significantly different from the global genome-wide proportion estimated by cluster analysis (34.7% Brahman), and the proportion expected by pedigree (37.5% Brahman). The analysis of selection signatures by genetic differentiation (F st ) and extended haplotype homozygosity-based methods (iHS and Rsb) revealed 10 and seven candidate regions, respectively. The analysis of the genes located within these candidate regions showed mainly genes involved in immune response-related pathway, while other genes and pathways were also observed (cell surface signalling pathways, membrane proteins and ion-binding proteins). Our results suggest that the BoLA region of Brangus cattle may have been enriched with Brahman haplotypes as a consequence of selection processes to promote adaptation to subtropical environments.

  2. Analysis and frequency of bovine lymphocyte antigen (BoLA-DRB3) alleles in Iranian Holstein cattle.

    PubMed

    Nassiry, M R; Shahroodi, F Eftekhar; Mosafer, J; Mohammadi, A; Manshad, E; Ghazanfari, S; Mohammad Abadi, M R; Sulimova, G E

    2005-06-01

    The bovine lymphocyte antigen (BoLA-DRB3) gene encodes cell surface glycoproteins that initiate immune response by presenting processed antigenic peptides to CD4 T helper cells. DRB3 is the most polymorphic bovine MHC class II gene which encodes the peptide-binding groove. DRB3 gene has been extensively evaluated as a candidate marker for association with various bovine diseases and immunological traits. This study describes genetic variability in the BoLA-DRB3 in Iranian Holstein cattle. This is the first study of the DNA polymorphism of the BoLA-DRB3 gene in Iranian Holstein cattle. Hemi-nested PCR-RFLP method is used for identification the frequency of BoLA-DRB3 alleles. The BoLA-DRB3 locus is highly polymorphic in the studied herd (26 alleles). Almost 67% of the alleles were accounted for four alleles (BoLA-DRB3.2*8, *24, *11 and *16) in Iranian Holstein cattle. The DRB3.2*8 allele frequency (26.6%) was higher than the others. The frequencies of the DRB3.2*54, *37, *36, *28, *25, *14, *13, *10, *1 alleles were lower than 1%. Significant distinctions have been found between Iranian Holstein cattle and other cattle breeds studied. In Iranian Holstein cattle the alleles (BoLA-DRB3.2*22, *2 and *16) associated with a lower risk of cystic ovarian disease in Holstein cattle are found. The alleles associated with the resistance to mastitis and to bovine leukemia virus infection BoLA-DRB3.2*11 and *23 are detected with the frequencies 10.4% and 4.4%, respectively. Thus in the Iranian Holstein cows studied are found alleles which are associated with resistance to various diseases. The method of DNA-typing of animals can be used in agricultural practice for BoLA-DRB3 allele genotyping of cattle in order to reduce spreading of alleles providing susceptibility to mastitis or leukemia in cattle herds.

  3. Kale BoRACK1 is involved in the plant response to salt stress and Peronospora brassicae Gaumann.

    PubMed

    Li, Da-Hong; Shen, Fu-Jia; Li, Hong-Yan; Li, Wei

    2017-06-01

    The receptor for activated C kinase 1 (RACK1) belongs to a protein subfamily containing a tryptophan-aspartic acid-domain (WD) repeat structure. Compelling evidence indicates that RACK1 can interact with many signal molecules and affect different signal transduction pathways. In this study, a kale (Brassica oleracea var. acephala f.tricolor) RACK1 gene (BoRACK1) was cloned by RT-PCR. The amino acid sequence of BoRACK1 had seven WD repeats in which there were typical GH (glycine-histidine) and WD dipeptides. Comparison with AtRACK1 from Arabidopsis revealed 87.1% identity at the amino acid level. Expression pattern analysis by RT-PCR showed that BoRACK1 was expressed in all analyzed tissues of kale and that its transcription in leaves was down-regulated by salt, abscisic acid, and H2O2 at a high concentration. Overexpression of BoRACK1 in kale led to a reduction in symptoms caused by Peronospora brassicae Gaumann on kale leaves. The expression levels of the pathogenesis-related protein genes, PR-1 and PRB-1, increased 2.5-4-fold in transgenic kale, and reactive oxygen species production was more active than in the wild-type. They also exhibited increased tolerance to salt stress in seed germination. H2O2 may also be involved in the regulation of BoRACK1 during seed germination under salt stress. Quantitative real-time PCR analyses showed that the transcript levels of BoRbohs genes were significantly higher in overexpression of BoRACK1 transgenic lines. Yeast two-hybrid assays showed that BoRACK1 could interact with WNK8, eIF6, RAR1, and SGT1. This study and previous work lead us to believe that BoRACK1 may form a complex with regulators of plant salt and disease resistance to coordinate kale reactions to pathogens. Copyright © 2017 Elsevier GmbH. All rights reserved.

  4. Strontium ions concentration dependent modifications on structural and optical features of Li4Sr(BO3)3 glass

    NASA Astrophysics Data System (ADS)

    Obayes, Hayder Khudhair; Wagiran, H.; Hussin, R.; Saeed, M. A.

    2016-05-01

    Composition optimization is essential for achieving improved properties of strontium (Sr2+) doped lithium borate (LSBO) glass. Glasses with compositions (85-x)H3BO3+15Li2CO3+xSrCO3, where x = 0.5-2.5 mol% are synthesized via melt quenching technique. Glasses are characterized to determine Sr2+ ions concentration dependent improvements in the structural, physical, and optical properties. XRD patterns verifies the amorphous nature, FESEM images reveals transmitting surface morphology, stable glasses with Hurby parameter ∼0.5 are achieved. FTIR spectra revealed three fundamental peaks around 700.55-930.68 and 1072.07 cm-1, which corresponded to the trigonal and tetrahedral stretching vibrations of BO3 and BO4 units. These peaks are shifted with the increase of modifier concentration. Energy for Urbach tail, direct and indirect optical gaps are calculated. The increasing glass refractive index from 2.34 to 3.00 is ascribed to the conversion of BO4 into BO3 units. Emission spectra exhibit three peaks centered at 492.65, 536 and 549 nm, corresponding to the transitions from the 1D2, 3D3 and 3D2 levels to ground state 1S0 respectively, and accompanied by a slight blueshift attributed to the formation of new complexes. Effects of strontium ion contents on the structural and optical properties are demonstrated. Our observation may contribute towards the development of LSBO based glass photonics.

  5. Crystal structure and magnetic anisotropy of ludwigite Co{sub 2}FeO{sub 2}BO{sub 3}

    SciTech Connect

    Ivanova, N. B.; Kazak, N. V.; Knyazev, Yu. V.; Velikanov, D. A.; Bezmaternykh, L. N.; Ovchinnikov, S. G.; Vasiliev, A. D.; Platunov, M. S.; Bartolome, J.; Patrin, G. S.

    2011-12-15

    Co{sub 3}O{sub 2}BO{sub 3} and Co{sub 2}FeO{sub 2}BO{sub 3} single crystals with a ludwigite structure are fabricated, and their crystal structure and magnetic properties are studied in detail. Substituted ludwigite Co{sub 2}FeO{sub 2}BO{sub 3} undergoes two-stage magnetic ordering at the temperatures characteristic of Fe{sub 3}O{sub 2}BO{sub 3} (T{sub N1} Almost-Equal-To 110 K, T{sub N2} Almost-Equal-To 70 K) rather than Co{sub 3}O{sub 2}BO{sub 3} (T{sub N} = 42 K). This effect is explained in terms of preferred occupation of nonequivalent crystallographic positions by iron, which was detected by X-ray diffraction. Both materials exhibit a pronounced uniaxial magnetic anisotropy. Crystallographic direction b is an easy magnetization axis. Upon iron substitution, the cobalt ludwigite acquires a very high magnetic hardness.

  6. Gene frequency distribution of the BoLA-DRB3 locus in Saavedreño Creole dairy cattle.

    PubMed

    Ripoli, M V; Lirón, J P; De Luca, J C; Rojas, F; Dulout, F N; Giovambattista, G

    2004-08-01

    The objective of this study is to describe the gene frequency distribution of the bovine lymphocyte antigen (BoLA)-DRB3 locus in Saavedreño Creole dairy cattle and to compare it with previously reported patterns in other cattle breeds. One hundred and twenty-five Saavedreño Creole dairy cattle were genotyped for the BoLA-DRB3.2 allele by polymerase chain reaction and restriction fragment length polymorphism. Twenty-two out of 53 previously identified BoLA-DRB3.2 alleles were detected, with gene frequencies ranging from 0.4 to 16.8%. Seventy percent of the variation corresponded to the seven most frequent alleles (BoLA-DRB3.2*7, *8, *11, *16, *27, *36, and *37). The studied population exhibits a high degree of expected heterozygosity (he = 0.919). The FIS index did not show significant deviation from Hardy-Weinberg equilibrium. However, the neutrality test showed an even gene frequency distribution. This result could be better explained assuming balancing selection instead of neutral or positive selection for one or a few alleles. In conclusion, the results of this study demonstrated that BoLA-DRB3.2 is a highly polymorphic locus in Saavedreño Creole dairy cattle, with significant variation in allele frequency among cattle breeds.

  7. Interatomic Potential for Hydrocarbons on the Basis of the Modified Embedded-Atom Method with Bond Order (MEAM-BO).

    PubMed

    Mun, Sungkwang; Bowman, Andrew L; Nouranian, Sasan; Gwaltney, Steven R; Baskes, Michael I; Horstemeyer, Mark F

    2017-02-23

    In this paper, we develop a new modified embedded atom method (MEAM) potential that includes the bond order (MEAM-BO) to describe the energetics of unsaturated hydrocarbons (double and triple carbon bonds) and also develop improved parameters for saturated hydrocarbons from those of our previous work. Such quantities like bond lengths, bond angles, and atomization energies at 0 K, dimer molecule interactions, rotational barriers, and the pressure-volume-temperature relationships of dense systems of small molecules give a comparable or more accurate property relative to experimental and first-principles data than the classical reactive force fields REBO and ReaxFF. Our extension of the MEAM potential for unsaturated hydrocarbons (MEAM-BO) is a step toward developing more reliable and accurate polymer simulations with their associated structure-property relationships, such as reactive multicomponent (organic/metal) systems, polymer-metal interfaces, and nanocomposites. When the constants for the BO are zero, MEAM-BO reduces to the original MEAM potential. As such, this MEAM-BO potential describing the interaction of organic materials with metals within the same MEAM formalism is a significant advancement for computational materials science.

  8. Bonn eXperimental System (BoXS): An open-source platform for interactive experiments in psychology and economics.

    PubMed

    Seithe, Mirko; Morina, Jeronim; Glöckner, Andreas

    2016-12-01

    The increased interest in complex-interactive behavior on the one hand and the cognitive and affective processes underlying behavior on the other are a challenge for researchers in psychology and behavioral economics. Research often necessitates that participants strategically interact with each other in dyads or groups. At the same time, to investigate the underlying cognitive and affective processes in a fine-grained manner, not only choices but also other variables such as decision time, information search, and pupil dilation should be recorded. The Bonn eXperimental System (BoXS) introduced in this article is an open-source platform that allows interactive as well as non-interactive experiments to be conducted while recording process measures very efficiently and completely browser-based. In the current version, BoXS has particularly been extended to enable conducting interactive eye-tracking and mouse-tracking experiments. One core advantage of BoXS is its simplicity. Using BoXS does not require prior installation for both experimenters and participants, which allows for running studies outside the laboratory and over the internet. Learning to program for BoXS is easy even for researchers without previous programming experience.

  9. Quantum phase transitions in the orthogonal dimer system SrCu 2(BO 3) 2

    NASA Astrophysics Data System (ADS)

    Kageyama, Hiroshi; Mushnikov, Nikoray V.; Yamada, Masaki; Goto, Tsuneaki; Ueda, Yutaka

    2003-05-01

    Inspired by recent enthusiastic theoretical works on the phase diagram of the (generalized) Shastry-Sutherland model, we measured the temperature dependence of magnetic susceptibility of SrCu 2(BO 3) 2 at high pressures up to 7 kbar. We employed a clumping type of a pressure cell made by CuTi alloys, which allows us to obtain the sample magnetization with a high sensitivity. We found that the temperature at maximum susceptibility decreases with increasing pressure, implying the reduction of the spin gap. This result strongly suggests that the system nears the phase boundary to an antiferromagnetically ordered or a plaquette singlet state.

  10. Rotational magnetocaloric effect in TbAl3(BO3)4

    NASA Astrophysics Data System (ADS)

    Pashchenko, M. I.; Bedarev, V. A.; Merenkov, D. N.; Bludov, A. N.; Pashchenko, V. A.; Gnatchenko, S. L.; Zajarniuk, T.; Szewczyk, A.; Temerov, V. L.

    2017-05-01

    A rotational magnetocaloric effect is predicted in the TbAl3(BO3)4 crystal based on the results of measuring field dependences of magnetization and the temperature dependence of heat capacity. The effect is modeled using the quasi-doublet approximation. Changes to the crystal entropy at constant temperature are determined, as well as at varying temperature under adiabatic conditions. The refrigerant capacity of the crystal is estimated. It is shown that terbium aluminum borate is a promising material for magnetic cooling.

  11. Nonlinear optical materials based on MBe2BO3F2 (M=Na,K)

    NASA Astrophysics Data System (ADS)

    Mei, Linfeng; Wang, Yebin; Chen, Chuangtian; Wu, Bochuang

    1993-12-01

    In a detailed analysis on the component elements, beryllium borate was chosen, and the alkaline metal beryllium borate fluorides MBe2BO3F2 (MBBF) (M = Na, K) were investigated. The compounds MBBF (M = Na, K) were synthesized by normal solid state reaction from the MBF4-BeO systems at 650-800 C, and the MBBF (M = Na, K) crystals were grown by the flux method. MBFF (Na,K) are promising candidates for VUV NLO crystals. A VUV NLO crystal can play an important role in laser chemistry, laser medical science and other fields.

  12. Numerical and experimental flow analysis of the Wang-Zwische double-lumen cannula.

    PubMed

    De Bartolo, Carmine; Nigro, Alessandra; Fragomeni, Gionata; Colacino, Francesco M; Wang, Dongfang; Jones, Cameron C; Zwischenberger, Joseph

    2011-01-01

    An experimental and numerical analysis was performed for the Wang-Zwische double-lumen cannula (DLC) (Avalon Elite). The aim of this work was to provide insight for future improvement by characterizing the fluid dynamic behavior of the novel catheter with metrics often associated with blood trauma. Pressure and flow distributions were measured on a steady-flow rig using a 50% glycerol-water mixture by imposing a 2 L/min flow rate across the drainage and infusion lumens. The fluid was modeled as Newtonian with density of 1050 kg/m³ and dynamic viscosity of 0.0035 kg/m·s. Reynolds numbers typical for transitional flow (Re = 2000-2500) were computed within the lumens because of the changing cross-sections of the cannula geometry. Numerical computations were performed using the steady three-dimensional Reynolds-averaged Navier-Stokes (RANS) equations and the low-Reynolds k-ω turbulence model. Discretization of governing equations was based on a cell-centered finite volume method. Numerical results correlated well with global performance of the cannula, allowing evaluation of the geometry toward potential blood trauma. Peak wall shear stress (WSS) in the drainage lumen was higher than that of infusion lumen, mainly due to the presence of side holes. Furthermore, recirculation regions were predicted in transition tubing to connectors of both the drainage and the infusion lumens because of adverse pressure gradients caused by the sudden enlargement of the cannula geometry. In this three-dimensional computational fluid dynamics (CFD) study, we observed higher peak WSS values for the drainage lumen, which may potentially cause blood trauma. Furthermore, recirculation regions were predicted in the proximity of the exit sections of both the infusion and drainage lumens, which may contribute to thrombosis formation. This study provides insight for future DLC modifications in minimizing cannula-induced blood trauma and thrombogenicity in long-term applications.

  13. Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis.

    PubMed

    Ahn, Chang Sook; Cho, Hui Kyung; Lee, Du-Hwa; Sim, Hee-Jung; Kim, Sang-Gyu; Pai, Hyun-Sook

    2016-09-01

    The nucleolar protein pescadillo (PES) controls biogenesis of the 60S ribosomal subunit through functional interactions with Block of Proliferation 1 (BOP1) and WD Repeat Domain 12 (WDR12) in plants. In this study, we determined protein characteristics and in planta functions of BOP1 and WDR12, and characterized defects in plant cell growth and proliferation caused by a deficiency of PeBoW (PES-BOP1-WDR12) proteins. Dexamethasone-inducible RNAi of BOP1 and WDR12 caused developmental arrest and premature senescence in Arabidopsis, similar to the phenotype of PES RNAi. Both the N-terminal domain and WD40 repeats of BOP1 and WDR12 were critical for specific associations with 60S/80S ribosomes. In response to nucleolar stress or DNA damage, PeBoW proteins moved from the nucleolus to the nucleoplasm. Kinematic analyses of leaf growth revealed that depletion of PeBoW proteins led to dramatically suppressed cell proliferation, cell expansion, and epidermal pavement cell differentiation. A deficiency in PeBoW proteins resulted in reduced cyclin-dependent kinase Type A activity, causing reduced phosphorylation of histone H1 and retinoblastoma-related (RBR) protein. PeBoW silencing caused rapid transcriptional modulation of cell-cycle genes, including reduction of E2Fa and Cyclin D family genes, and induction of several KRP genes, accompanied by down-regulation of auxin-related genes and up-regulation of jasmonic acid-related genes. Taken together, these results suggest that the PeBoW proteins involved in ribosome biogenesis play a critical role in plant cell growth and survival, and their depletion leads to inhibition of cell-cycle progression, possibly modulated by phytohormone signaling. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  14. Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis

    PubMed Central

    Ahn, Chang Sook; Cho, Hui Kyung; Lee, Du-Hwa; Sim, Hee-Jung; Kim, Sang-Gyu; Pai, Hyun-Sook

    2016-01-01

    The nucleolar protein pescadillo (PES) controls biogenesis of the 60S ribosomal subunit through functional interactions with Block of Proliferation 1 (BOP1) and WD Repeat Domain 12 (WDR12) in plants. In this study, we determined protein characteristics and in planta functions of BOP1 and WDR12, and characterized defects in plant cell growth and proliferation caused by a deficiency of PeBoW (PES-BOP1-WDR12) proteins. Dexamethasone-inducible RNAi of BOP1 and WDR12 caused developmental arrest and premature senescence in Arabidopsis, similar to the phenotype of PES RNAi. Both the N-terminal domain and WD40 repeats of BOP1 and WDR12 were critical for specific associations with 60S/80S ribosomes. In response to nucleolar stress or DNA damage, PeBoW proteins moved from the nucleolus to the nucleoplasm. Kinematic analyses of leaf growth revealed that depletion of PeBoW proteins led to dramatically suppressed cell proliferation, cell expansion, and epidermal pavement cell differentiation. A deficiency in PeBoW proteins resulted in reduced cyclin-dependent kinase Type A activity, causing reduced phosphorylation of histone H1 and retinoblastoma-related (RBR) protein. PeBoW silencing caused rapid transcriptional modulation of cell-cycle genes, including reduction of E2Fa and Cyclin D family genes, and induction of several KRP genes, accompanied by down-regulation of auxin-related genes and up-regulation of jasmonic acid-related genes. Taken together, these results suggest that the PeBoW proteins involved in ribosome biogenesis play a critical role in plant cell growth and survival, and their depletion leads to inhibition of cell-cycle progression, possibly modulated by phytohormone signaling. PMID:27440937

  15. A modern approach for epitope prediction: identification of foot-and-mouth disease virus peptides binding bovine leukocyte antigen (BoLA) class I molecules.

    PubMed

    Pandya, Mital; Rasmussen, Michael; Hansen, Andreas; Nielsen, Morten; Buus, Soren; Golde, William; Barlow, John

    2015-11-01

    Major histocompatibility complex (MHC) class Imolecules regulate adaptive immune responses through the presentation of antigenic peptides to CD8+ T cells. Polymorphisms in the peptide binding region of class I molecules determine peptide binding affinity and stability during antigen presentation, and different antigen peptide motifs are associated with specific genetic sequences of class I molecules. Understanding bovine leukocyte antigen (BoLA), peptide-MHC class I binding specificities may facilitate development of vaccines or reagents for quantifying the adaptive immune response to intracellular pathogens, such as foot-and-mouth disease virus (FMDV). Six synthetic BoLA class I (BoLA-I) molecules were produced, and the peptide binding motif was generated for five of the six molecules using a combined approach of positional scanning combinatorial peptide libraries (PSCPLs) and neural network-based predictions (NetMHCpan). The updated NetMHCpan server was used to predict BoLA-I binding peptides within the P1 structural polyprotein sequence of FMDV (strain A24 Cruzeiro) for Bo-LA-1*01901, BoLA-2*00801, BoLA-2*01201, and BoLA-4*02401. Peptide binding affinity and stability were determined for these BoLA-I molecules using the luminescent oxygen channeling immunoassay (LOCI) and scintillation proximity assay (SPA). The functional diversity of known BoLA alleles was predicted using theMHCcluster tool, and functional predictions for peptide motifs were compared to observed data from this and prior studies. The results of these analyses showed that BoLA alleles cluster into three distinct groups with the potential to define BBoLA supertypes.^ This streamlined approach identifies potential T cell epitopes from pathogens, such as FMDV, and provides insight into T cell immunity following infection or vaccination.

  16. A highly selective fluorescent probe for BO3(-) based on acetate derivatives of coumarin in aqueous solution and thimerosal.

    PubMed

    Huo, Fangjun; Wang, Long; Yang, Yutao; Chu, Yueyin; Yin, Caixia; Chao, Jianbin; Zhang, Yongbin; Yan, Xuxiu; Zheng, Anmin; Jin, Shuo; Zhi, Peng

    2013-02-21

    The acetate derivatives of coumarin exhibited a prominent turn-on type signaling behavior toward BO(3)(-) ions over other common anions. Signaling is based on the selective deprotection of acetate groups by perborate, which resulted in significant fluorogenic signaling in an acetate buffered solution (pH 5.0). Interestingly, the detection process makes the raw material of 7-hydroxycoumarin regenerate, and the probe could be applied for the detection of BO(3)(-) of thimerosal. Furthermore, the optical properties of the probe and its BO(3)(-)-induced product were theoretically studied based on density functional theory (DFT) and the time-dependent DFT (TDDFT) explored at the B3LYP/6-311+G (d, p) level.

  17. [DNA polymorphism of the BoLA-DRB3 gene in cattle in connection with resistance and susceptibility to leukemia].

    PubMed

    Sulimova, G E; Udina, I G; Shaĭkhaev, G O; Zakharov, I A

    1995-09-01

    Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2*11, *23, and *28) and susceptibility to leukemia (DRB3.2*22, *24, *16, and *8) were revealed in Black Pied cattle. The dominant type of inheritance of the disease resistance was confirmed. On the basis of original and published data obtained earlier for Holstein-Friesian cattle, a conclusion was made about the universal character of the spectrum of BoLA-DRB3 alleles providing resistance and susceptibility to leukemia.

  18. Thermal quenching of luminescence of LiSr4 (BO3)3:Eu2+ orange-emitting phosphor.

    PubMed

    Zhang, Xinguo; Zhou, Liya; Gong, Menglian

    2014-03-01

    An orange-emitting phosphor, Eu(2+)-activated LiSr4(BO3)3, was synthesized using the conventional solid-state reaction. The photoluminescence excitation and emission spectra, and temperature dependence of the luminescence intensity of the phosphor were investigated. The results showed that LiSr4(BO3)3:Eu(2+) could be efficiently excited by incident light of 250-450 nm, and emits a strong orange light. With increasing temperature, the emission bands of LiSr4(BO3)3:Eu(2+) show an abnormal blue-shift with broadening bandwidth and decreasing emission intensity. Copyright © 2013 John Wiley & Sons, Ltd.

  19. DNA polymorphism at the BoLA-DRB3 gene of cattle in relation to resistance and susceptibility to leukemia

    SciTech Connect

    Sulimova, G.E.; Udina, I.G.; Shaikhaev, G.O.

    1995-09-01

    Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2{sup *}11, {sup *}23, and {sup *}28) and susceptibility to leukemia (DRB3.2{sup *}22, {sup *}24, {sup *}16, and {sup *}8) were revealed in Black Pied cattle. The dominant type of inheritance of the disease resistance was confirmed. On the basis of original and published data obtained earlier for Holstein-Friesian cattle, a conclusion was made about the universal character of the spectrum of BoLA-DRB3 alleles providing resistance and susceptibility to leukemia. 18 refs., 1 fig., 3 tabs.

  20. Non-linear conduction due to depinning of charge order domains in Fe3O2BO3

    NASA Astrophysics Data System (ADS)

    dos Santos, E. C.; da Silva, E. F.; Fernandes, J. C.; Ghivelder, L.; Freitas, D. C.; Continentino, M. A.; Walmsley, L.

    2017-05-01

    The oxyborate Fe3O2BO3 presents a charge density wave (CDW) transition close to room temperature. As we show here, this is associated with a well defined anomaly in the specific heat. Below this transition, when applying in a single crystal of Fe3O2BO3 a DC voltage above a temperature dependent threshold, a high current is liberated in this material. We study the conduction in single crystals of Fe3O2BO3 with voltage applied parallel and perpendicular to the crystallographic c axis direction. The observed currents are attributed to the depinning of charge ordered domains above a threshold voltage V T2 that gives rise to a collective conduction due to coherent domains. Compliance limited DC data shows that above a lower threshold voltage depinning is smooth and follows a power law scaling. Similar depinning with power law scaling is also revealed in the AC conductivity.

  1. Electron transport in FeBO3 ferroborate at ultrahigh pressures

    NASA Astrophysics Data System (ADS)

    Troyan, I. A.; Gavrilyuk, A. G.; Ovchinnikov, S. G.; Lyubutin, I. S.; Kazak, N. V.

    2012-01-01

    The electrical resistance of FeBO3 crystals at high and ultrahigh pressures (up to 198 GPa) and low temperatures has been measured using diamond anvil cells. It has found that in the high-pressure phase, 46 GPa < P < 100 GPa, the activation energy E ac decreases gradually from 0.55 to 0.3 eV according to a linear law. Its extrapolation to zero gives an estimated value of about 210 GPa for the pressure at which complete metallization is expected. However, above 100 GPa, the linear E ac( P) dependence smoothly transforms to a nonlinear one. At the same time, the temperature dependence of the electrical resistance at fixed pressure significantly deviates from the Arrhenius activation law and does not obey the Mott law for the hopping conductivity. Experimental data demonstrate the dependence of the activation energy E ac both on pressure and temperature. At T = 0, the gap tends to zero. Theoretical analysis shows that the decrease in E ac upon cooling can be interpreted in terms of the transition of the low-spin FeBO3 phase to the magnetically ordered (antiferromagnetic) state.

  2. Infrared Diode Laser Spectrum of the nu(1) Fundamental Band of ClBO.

    PubMed

    Hunt; Röpcke; Davies

    2000-11-01

    The nu(1) band of ClBO has been recorded using infrared diode laser spectroscopy. The molecule was produced by reacting oxygen atoms, produced in a microwave discharge containing an O(2)/He mixture, with BCl(3). Thirty-three lines of the (35)Cl(11)B(16)O isotopomer and 32 lines due to the (37)Cl(11)B(16)O isotopomer have been assigned. By fixing the ground state constants to those previously obtained by microwave spectroscopy, a least-squares fit (rms = 0.0008) gave the following upper state constants; (35)Cl(11)B(16)O: nu(0) = 1972.18024(21) cm(-1), B(1) = 0.1725055(12) cm(-1); (37)Cl(11)B(16)O: nu(0) = 1971.82846(24) cm(-1), B(1) = 0.1688402(13) cm(-1). The rotational constants of all the fundamental bands of ClBO have been used to calculate an r(e) structure yielding r(e(B-Cl)) = 167.668(26) pm and r(e(B-O)) = 121.308(26) pm. Copyright 2000 Academic Press.

  3. Structure of the BoLA-DRB3 gene and promoter.

    PubMed

    Russell, G C; Smith, J A; Oliver, R A

    2004-06-01

    The cattle major histocompatibility complex (MHC) class II DR gene product is a heterodimer encoded by the BoLA-DRA and -DRB3 genes. Several groups have isolated cDNA and genomic clones for these genes, but their full genomic organization has not been described. We used a combination of long-range polymerase chain reaction (PCR), cloning and sequencing to define the organization of the DRB3 gene on existing genomic clones and in genomic DNA. We estimate the size of the coding region to be 11.4 kbp. Sequencing of full-length PCR clones from two different haplotypes confirmed that they carried complete DRB3 genes and allowed the design of probes and primers to isolate and characterize the DRB3 promoter and 3' end. Fragments carrying the 5' end of the DRB3 gene and its promoter were identified on bacterial artificial chromosome (BAC) clones carrying the BoLA-DR genes. A 10-kbp promoter fragment was subcloned from one clone and a 1.7-kbp region including exon 1 and the promoter was sequenced. A 3-kbp fragment encoding exons 4-6 and the entire 3' untranslated region of the DRB3 gene was isolated from lambda clone A1 and sequenced. This provides us with improved characterization of the DRB3*0101 and DRB3*2002 alleles, and also subcloned 5' and 3' flanking regions of the polymorphic DRB3 gene for use in functional studies.

  4. BoLA-DRB3 exon 2 mutations associated with paratuberculosis in cattle.

    PubMed

    Rastislav, Mucha; Mangesh, Bhide

    2012-06-01

    A single nucleotide polymorphism at the antigen recognition site of the bovine leucocyte antigen (BoLA) DRB3 gene was assessed in healthy and Mycobacterium avium subsp. paratuberculosis (MAP) - infected cattle, in order to determine if there was a correlation between mutations and altered susceptibility to infection. Of a sample of 200 animals, 19.6% were found to be infected with MAP. PCR - single strand conformational polymorphism analysis of the BoLA DRB3 gene found 19 genotypes (16 in the heterozygous and three in homozygous state, respectively). Four mutations, Val53Glu (OR 453.7), Val53Leu (OR 453.7), Asp57His (OR 1.944) and Arg84Gly (OR 1.458), were linked with increased susceptibility to infection, whereas, Asp57Asn (OR 0) and Phe60Tyr (OR 0.453) were associated with increased resistance. The findings indicate potentially important mutations in the protein-binding site of DRB3, which may be crucial to the activation of an appropriate immune response against MAP.

  5. Magnetoelectric effect in ytterbium aluminum borate YbAl3(BO3)4

    NASA Astrophysics Data System (ADS)

    Ivanov, V. Yu.; Kuzmenko, A. M.; Mukhin, A. A.

    2017-04-01

    The anisotropic magnetoelectric properties of an ytterbium aluminum borate YbAl (BO single crystal having noncentrosymmetric crystal structure (space group R32) are studied, including the orientational, field, and temperature dependences of the polarization in magnetic fields up to 5 T in the temperature range of 2-300 K. It has been shown experimentally for the first time that the symmetry of the observed magnetoelectric effects exactly corresponds to the trigonal structure of the crystal and is characterized by two quadratic magnetoelectric constants. The polarization in the basal plane P a, b is a quadratic function of the field at low fields and reaches 250-300 μC/m2 in a field of 5 T at a temperature of 2 K, almost an order of magnitude exceeding the previously reported values. A theoretical model based on the spin Hamiltonian of the ground Kramers doublet of Yb3+ ions in the crystal field is proposed including magnetoelectric interactions allowed by the symmetry. This model makes it possible to quantitatively describe all observed magnetic and magnetoelectric properties of YbAl3(BO3)4.

  6. Growth of (Er,Yb):YAl{sub 3}(BO{sub 3}){sub 4} laser crystals

    SciTech Connect

    Pilipenko, O. V. Mal'tsev, V. V.; Koporulina, E. V.; Leonyuk, N. I.; Tolstik, N. A.; Kuleshov, N. V.

    2008-03-15

    (Er,Yb):YAl{sub 3}(BO{sub 3}){sub 4} single crystals of optical quality, up to 15 Multiplication-Sign 10 Multiplication-Sign 10 mm{sup 3} in size, have been grown from a (Er{sub 0.023}Yb{sub 0.116}Y{sub 0.862})Al{sub 3}(BO{sub 3}){sub 4} solution in a Y{sub 2}O{sub 3}-B{sub 2}O{sub 3}-K{sub 2}Mo{sub 3}O{sub 10} melt. The initial borate concentration was 17 wt %, and the flux cooling rate increased from 0.08 to 0.12 Degree-Sign C/h in the range 1060-1000 Degree-Sign C. The physical properties of the single crystals grown are good enough that they can be used as laser elements in systems with diode pumping and radiation near 1.5 {mu}m.

  7. Synthesis and stimulated luminescence property of Zn(BO2)2:Tb(3).

    PubMed

    Del Rosario, G Cedillo; Cruz-Zaragoza, E; Hipólito, M García; Marcazzó, J; Hernández A, J M; Murrieta S, H

    2017-09-01

    Zinc borate, Zn(BO2)2, doped with different concentrations of terbium (0.5-8mol%) was synthesized and polycrystalline samples were characterized by Scanning Electron Microscopy and X-Ray Diffraction. The Zn(BO2)2 was formed in the pure samples sintered at 750 and 800°C which has the body centered cubic structure, and a ZnB4O7 primitive orthorhombic phase was present. The thermoluminescent intensity was dependents on the thermal treatment (250-500°C) and also on the impurity concentration. The linear dose-response was obtained between 0.022-27.7Gy and 0.5-50Gy when the samples were exposed to beta and gamma radiation, respectively. The complex structure of the glow curves was analyzed by the Computerized Glow Curve Deconvolution method. The kinetics parameters were calculated assuming the general order kinetics model describing accurately the TL process. The glow curves of Tb(3+)-doped zinc borate phosphor were well deconvolved by six glow peaks. Zinc borate with 8mol% of impurity concentration exhibited an intense radioluminescent emission. The radioluminescent spectra show their maximum bands at 370, 490, 545 and 700nm related to the terbium ion in the zinc borate. These obtained results suggest that the terbium doped zinc borate is a promising phosphor for use in radiation dosimetry because of its high TL sensitivity to the ionizing radiation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis.

    PubMed

    Maillard, Jean-Charles; Berthier, David; Chantal, Isabelle; Thevenon, Sophie; Sidibé, Issa; Stachurski, Frederic; Belemsaga, Désiré; Razafindraïbé, Hanta; Elsen, Jean-Michel

    2003-01-01

    Bovine dermatophilosis is a severe skin infection of tropical ruminants inducing a severe loss in productivity and a 15% mortality rate. This disease is caused by the actinomycete bacterium Dermatophilus congolensis associated with the tick Amblyomma variegatum. Currently there are no prospects for a vaccine, and acaricide or antibiotic control is hampered by the development of chemoresistance. Animal breeders have observed that dermatophilosis susceptibility seems to be determined genetically, and we previously identified a BoLA-DRB3-DQB class II haplotype marker for high (R2= 0.96) susceptibility to the disease. With this marker, we developed a successful eugenic selection procedure for zebu Brahman cattle in Martinique (FWI). Over a period of five years, a marked reduction in disease prevalence, from 0.76 to 0.02 was achieved, and this low level has been maintained over the last two years. The selection procedure, based on a genetic marker system targeting the highly polymorphic BoLA locus, eliminates only those individuals which are at the highest risk of contracting the disease. In the present work, we discuss the properties of this system, including the "heterozygote advantage" and the "frequency dependence" theories, and examine their involvement in the biological mechanisms at the host/pathogen interface. We speculate on the exact role of the MHC molecules in the control of the disease, how the natural selection pressure imposed by the pathogens selectively maintains MHC diversity, and how our results can be practically applied for integrated control of dermatophilosis in developing countries.

  9. Quaternary geology and sapphire deposits from the BO PHLOI gem field, Kanchanaburi Province, Western Thailand

    NASA Astrophysics Data System (ADS)

    Choowong, Montri

    2002-01-01

    One of the most famous blue sapphire deposits in Thailand and SE Asia is from the Bo Phloi District, Kanchanaburi Province, Western Thailand. This paper presents the results of our gemstone investigation as well as establishing the Bo Phloi depositional sequence as one of the Quaternary Type Sections in the region. Relationships among the sedimentology, depositional sequences and geomorphology were investigated in order to understand the gemstone depositional features. Sedimentary structures and textures of the sequences show that the deposition of gemstones is related genetically to fluvial processes. Gemstones are recognized in floodplain and low terrace deposits where gemstone paystreaks concentrate mostly inside layers of gravel beds and foreset-bedded gravels lithofacies. C-14 dating of wood and peat within gemstone-bearing layers indicated that the deposit formed during the middle to late Pleistocene. The gemstone-bearing gravel bed defines a north-south trend along the incised palaeo-channel of an ancient braided river system in the middle part of the basin.

  10. Na(+)-translocating cytochrome bo terminal oxidase from Vitreoscilla: some parameters of its Na+ pumping and orientation in synthetic vesicles.

    PubMed

    Park, C; Moon, J Y; Cokic, P; Webster, D A

    1996-09-10

    Vitreoscilla cytochrome bo ubiquinol oxidase is similar in some properties to the Escherichia coli enzyme, but unlike the latter, the Vitreoscilla oxidase functions as a primary Na+ pump. When purified Vitreoscilla cytochrome bo is incorporated into liposomes made from Vitreoscilla phospholipids and energized with a quinol substrate, it translocates Na+, not H+, across the vesicle membrane. Since protonophores CCCP (carbonyl cyanide m-chlorophenylhydrazone) and DTHB (3,5-di-tert-butyl-4-hydroxybenzaldehyde) stimulated the Na+ pumping, it is unlikely that it is a secondary effect due to the presence of Na+/H+ antiporter activity in the preparations. The efficiency of the Na+ pumping was 3.93 Na+ pumped per O2 consumed when ascorbate/TMPD was used as the substrate. The cytochrome has a K(m) and Kcat for Na+ of 2.9 mM and 277 s-1, respectively. When ferricytochrome c was entrapped within liposomes prepared from Vitreoscilla phospholipids, it was reduced by Q1H2 (ubiquinol-1) but not by ascorbate/TMPD (N,N,N',N'-tetramethyl-1,4-phenylenediamine). Although Q1H2 was oxidized by cytochrome bo in solution at a rate approximately 14 times that of the latter substrate, the rate of accumulation of Na+ within cytochrome bo vesicles driven by the membrane impermeable ascorbate/TMPD was 1.23 times that of the membrane permeable ubiquinol. These data allowed a calculation that in these synthetic proteoliposomes the cytochrome bo molecules are only 51% directed inward; a value of 61% inward-directed was estimated by measuring the ascorbate/TMPD oxidase activity of the proteoliposomes before and after disrupting them with Triton X-100. A random orientation of the E. coli cytochrome bo oxidase in proteoliposomes has also been reported.

  11. Body mass of prefledging Emperor Geese Chen canagica: Large-scale effects of interspecific densities and food availability

    USGS Publications Warehouse

    Lake, B.C.; Schmutz, J.A.; Lindberg, M.S.; Ely, C.R.; Eldridge, W.D.; Broerman, F.J.

    2008-01-01

    We studied body mass of prefledging Emperor Geese Chen canagica at three locations across the Yukon-Kuskokwim Delta, Alaska, during 1990-2004 to investigate whether large-scale variation in body mass was related to interspecific competition for food. From 1990 to 2004, densities of Cackling Geese Branta hutchinsii minima more than doubled and were c. 2-5?? greater than densities of Emperor Geese, which were relatively constant over time. Body mass of prefledging Emperor Geese was strongly related (negatively) to interspecific densities of geese (combined density of Cackling and Emperor Geese) and positively related to measures of food availability (grazing lawn extent and net above-ground primary productivity (NAPP)). Grazing by geese resulted in consumption of ??? 90% of the NAPP that occurred in grazing lawns during the brood-rearing period, suggesting that density-dependent interspecific competition was from exploitation of common food resources. Efforts to increase the population size of Emperor Geese would benefit from considering competitive interactions among goose species and with forage plants. ?? 2008 The Authors.

  12. Quality evaluation of Yin Chen Hao Tang extract based on fingerprint chromatogram and simultaneous determination of five bioactive constituents.

    PubMed

    Wang, Xijun; Lv, Haitao; Sun, Hui; Jiang, Xingang; Wu, Zeming; Sun, Wenjun; Wang, Ping; Liu, Lian; Bi, Kaishun

    2008-01-01

    A completely validated method based on HPLC coupled with photodiode array detector (HPLC-UV) was described for evaluating and controlling quality of Yin Chen Hao Tang extract (YCHTE). First, HPLC-UV fingerprint chromatogram of YCHTE was established for preliminarily elucidating amount and chromatographic trajectory of chemical constituents in YCHTE. Second, for the first time, five mainly bioactive constituents in YCHTE were simultaneously determined based on fingerprint chromatogram for furthermore controlling the quality of YCHTE quantitatively. The developed method was applied to analyze 12 batches of YCHTE samples which consisted of herbal drugs from different places of production, showed acceptable linearity, intraday (RSD <5%), interday precision (RSD <4.80%), and accuracy (RSD <2.80%). As a result, fingerprint chromatogram determined 15 representative general fingerprint peaks, and the fingerprint chromatogram resemblances are all better than 0.9996. The contents of five analytes in different batches of YCHTE samples do not indicate significant difference. So, it is concluded that the developed HPLC-UV method is a more fully validated and complete method for evaluating and controlling the quality of YCHTE.

  13. Plasma biochemistry values in emperor geese (Chen canagica) in Alaska: comparisons among age, sex, incubation, and molt.

    USGS Publications Warehouse

    Franson, J. Christian; Hoffman, D.J.; Schmutz, J.A.

    2009-01-01

    Reduced populations of emperor geese (Chen canagica), a Bering Sea endemic, provided the need to assess plasma biochemistry values as indicators of population health. A precursory step to such an investigation was to evaluate patterns of variability in plasma biochemistry values among age, sex, and reproductive period. Plasma from 63 emperor geese was collected on their breeding grounds on the Yukon-Kuskokwim Delta in western Alaska, USA. The geese sampled included 18 incubating adult females captured, in mid June, on their nests by using bow nets, and 30 adults and 15 goslings captured in corral traps in late July and early August, when the adults were molting their wing feathers and the goslings were 5-6 weeks old. Plasma was evaluated for 15 biochemical parameters, by comparing results among age, sex, and sampling period (incubation versus wing-feather molt). Ten of the 15 biochemical parameters assayed differed among adults during incubation, the adults during molt, and the goslings at molt, whereas sex differences were noted in few parameters.

  14. Plasma biochemistry values in emperor geese (Chen canagica) in Alaska: comparisons among age, sex, incubation, and molt.

    PubMed

    Franson, J Christian; Hoffman, David J; Schmutz, Joel A

    2009-06-01

    Reduced populations of emperor geese (Chen canagica), a Bering Sea endemic, provided the need to assess plasma biochemistry values as indicators of population health. A precursory step to such an investigation was to evaluate patterns of variability in plasma biochemistry values among age, sex, and reproductive period. Plasma from 63 emperor geese was collected on their breeding grounds on the Yukon-Kuskokwim Delta in western Alaska, USA. The geese sampled included 18 incubating adult females captured, in mid June, on their nests by using bow nets, and 30 adults and 15 goslings captured in corral traps in late July and early August, when the adults were molting their wing feathers and the goslings were 5-6 weeks old. Plasma was evaluated for 15 biochemical parameters, by comparing results among age, sex, and sampling period (incubation versus wing-feather molt). Ten of the 15 biochemical parameters assayed differed among adults during incubation, the adults during molt, and the goslings at molt, whereas sex differences were noted in few parameters.

  15. Simultaneous determination of 13 bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) from different harvest seasons by HPLC-DAD.

    PubMed

    Tan, Xiao-jie; Li, Qing; Chen, Xiao-hui; Wang, Zhi-wei; Shi, Zheng-yuan; Bi, Kai-shun; Jia, Ying

    2008-08-05

    Herba Artemisiae Scopariae is a Chinese herbal medicine widely used for the remedy of liver diseases. A high performance liquid chromatography method coupled with diode array detection was developed to simultaneously determine 13 different bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) including chlorogenic acid (1), 6,7-dihydroxycoumarin (2), caffeic acid (3), 4-hydroxyacetophenone (4), scopoletin (5), rutin (6), hyperoside (7), isoquercitrin (8), scoparone (11), 7-methoxycoumarine (12) and quercetin (13). By using four different wavelengths in the HPLC analysis, the developed method was able to determine the bioactive compounds with excellent resolution, precision and recovery. The method was applied to determine the amounts of the bioactive compounds in nine samples from different cultivated regions and harvest seasons in China, and significant variations were revealed. Chlorogenic acid was the most abundant among the analyzed compounds. The samples harvested in the spring contained higher contents of chlorogenic acid than those collected in other seasons. Other phenolic acids as caffeic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid and 4-hydroxyacetophenone accumulated at much higher amounts in about May to July. The samples analyzed contained a much lower level of the amount of other flavonoids and coumarins as rutin, hyperoside, isoquercitrin and scoparone.

  16. Explaining co-occurrence among helminth species of lesser snow geese (Chen caerulescens) during their winter and spring migration.

    PubMed

    Forbes, M R; Alisauskas, R T; McLaughlin, J D; Cuddington, K M

    1999-09-01

    The digestive tracts of 771 lesser snow geese (Chen caerulescens) collected from January to May 1983 from 12 locations (27 samples) were examined for helminth parasites to determine whether parasite species present in wintering geese or in spring migrants occurred independently of each other. Nine helminth species were identified. Seven had mean prevalences >5% and were the focus of this study. Six of those species were waterfowl generalists, one was a goose specialist. Our primary objective was to assess the potential contribution of factors, other than species interactions, in determining patterns of co-occurrence between helminth species. There were few negative relationships between helminth species, regardless of whether presence-absence or abundance data were used. However, some species pairs showed recurrent and significant co-occurrences. There were similar and significant effects of timing of sampling, host gender, and host age, on prevalence and mean abundance of particular species. Co-occurrences were found for those species that showed seasonal declines in prevalence, for those expected to have high colonizing ability based on host age profiles (using abundance data), and for abundant species that may have shared vectors or environmental conditions favorable for transmission. Thus, similarities between parasites in their abundance, transmission biology, and phenology seem sufficient to explain species co-occurrences without invoking other processes such as species interactions.

  17. Isolation and characterization of Brachyspira spp. including "Brachyspira hampsonii" from lesser snow geese (Chen caerulescens caerulescens) in the Canadian Arctic.

    PubMed

    Rubin, Joseph E; Harms, N Jane; Fernando, Champika; Soos, Catherine; Detmer, Susan E; Harding, John C S; Hill, Janet E

    2013-11-01

    Brachyspira is associated with diarrhea and colitis in pigs, and control of these pathogens is complicated by their complex ecology. Identification of wildlife reservoirs of Brachyspira requires the discrimination of colonized animals and those simply contaminated through environmental exposure. Lesser snow geese (Chen caerulescens caerulescens) were sampled in the Canadian arctic during the summer of 2011, and cloacal swabs were cultured on selective media. Brachyspira isolates were obtained from 15/170 (8.8 %) samples, and 12/15 isolates were similar to isolates previously recovered from pigs, including "Brachyspira hampsonii", a recently characterized species associated with dysentery-like disease in pigs in North America. A pilot inoculation study with one strongly β-hemolytic B. hampsonii isolate resulted in fecal shedding of the isolate by inoculated pigs for up to 14 days post-inoculation, but no severe clinical disease. Results of this study indicate that lesser snow geese can be colonized by Brachyspira strains that can also colonize pigs. Millions of lesser snow geese (C. caerulescens caerulescens) travel through the major pork-producing areas of Canada and the USA during their annual migration, making them a potential factor in the continental distribution of these bacteria.

  18. Satellite-derived land covers for runoff estimation using SCS-CN method in Chen-You-Lan Watershed, Taiwan

    NASA Astrophysics Data System (ADS)

    Zhang, Wen-Yan; Lin, Chao-Yuan

    2017-04-01

    The Soil Conservation Service Curve Number (SCS-CN) method, which was originally developed by the USDA Natural Resources Conservation Service, is widely used to estimate direct runoff volume from rainfall. The runoff Curve Number (CN) parameter is based on the hydrologic soil group and land use factors. In Taiwan, the national land use maps were interpreted from aerial photos in 1995 and 2008. Rapid updating of post-disaster land use map is limited due to the high cost of production, so the classification of satellite images is the alternative method to obtain the land use map. In this study, Normalized Difference Vegetation Index (NDVI) in Chen-You-Lan Watershed was derived from dry and wet season of Landsat imageries during 2003 - 2008. Land covers were interpreted from mean value and standard deviation of NDVI and were categorized into 4 groups i.e. forest, grassland, agriculture and bare land. Then, the runoff volume of typhoon events during 2005 - 2009 were estimated using SCS-CN method and verified with the measured runoff data. The result showed that the model efficiency coefficient is 90.77%. Therefore, estimating runoff by using the land cover map classified from satellite images is practicable.

  19. Comment on “Chen et al., Fabrication and photovoltaic conversion enhancement…”, Electrochimica Acta, 2014

    NASA Astrophysics Data System (ADS)

    Valentic, Lara; Gorji, Nima E.

    2015-09-01

    In a recent article, Chen et al. [Electrochimica Acta, 2014, 130: 279] presented their fabrication and characterization results on a graphene/n-Si solar cell where the Au nanoparticles were inserted in graphene to increase its optical and electrical properties. The higher efficiency of the device was attributed to increased conductivity of graphene after doping with Au nanoparticles. However, the knowledge in the field of Schottky diode solar cells relates this to increased band bending at the junction. Also, to explain the instability behaviour, they concluded that the growth of silicon oxide on the Si surface or oxygen adsorption on the window layer resulted in the device performance increasing initially and decreasing in the end. However, this instability seems to be due to variation in series resistance reduced at the beginning because of slightly lowered Fermi level and increased at the end by the self-compensation by deep in-diffusion of Au nanoparticles into n-Si layer. We also propose that inserting a very thin p-type layer at the junction will enhance the carrier collection and performance of this device.

  20. Sm3S3BO3: The First Sulfide Borate without S-O and B-S Bonds.

    PubMed

    Guo, Sheng-Ping; Chi, Yang; Xue, Huai-Guo

    2015-12-07

    An unprecedented quaternary sulfide borate, Sm3S3BO3 (1), was obtained via a high-temperature solid-state synthesis method. It crystallizes in the triclinic space group P1̅, and its 3D structure features a 2D (Sm2S2)∞ wrinkled layer and a 1D (SmS)∞ ladderlike chain bridged by trigonal-planar (BO3)(3-) through Sm-O bonds, demonstrating the first sulfide borate without S-O and B-S bonds. Its optical energy gap is measured to be around 2.5 eV and verified by electronic structure calculation.

  1. Genetics and fine mapping of a purple leaf gene, BoPr, in ornamental kale (Brassica oleracea L. var. acephala).

    PubMed

    Liu, Xiao-Ping; Gao, Bao-Zhen; Han, Feng-Qing; Fang, Zhi-Yuan; Yang, Li-Mei; Zhuang, Mu; Lv, Hong-Hao; Liu, Yu-Mei; Li, Zhan-Sheng; Cai, Cheng-Cheng; Yu, Hai-Long; Li, Zhi-Yuan; Zhang, Yang-Yong

    2017-03-14

    Due to its variegated and colorful leaves, ornamental kale (Brassica oleracea L. var. acephala) has become a popular ornamental plant. In this study, we report the fine mapping and analysis of a candidate purple leaf gene using a backcross population and an F2 population derived from two parental lines: W1827 (with white leaves) and P1835 (with purple leaves). Genetic analysis indicated that the purple leaf trait is controlled by a single dominant gene, which we named BoPr. Using markers developed based on the reference genome '02-12', the BoPr gene was preliminarily mapped to a 280-kb interval of chromosome C09, with flanking markers M17 and BoID4714 at genetic distances of 4.3 cM and 1.5 cM, respectively. The recombination rate within this interval is almost 12 times higher than the usual level, which could be caused by assembly error for reference genome '02-12' at this interval. Primers were designed based on 'TO1000', another B. oleracea reference genome. Among the newly designed InDel markers, BRID485 and BRID490 were found to be the closest to BoPr, flanking the gene at genetic distances of 0.1 cM and 0.2 cM, respectively; the interval between the two markers is 44.8 kb (reference genome 'TO1000'). Seven annotated genes are located within the 44.8 kb genomic region, of which only Bo9g058630 shows high homology to AT5G42800 (dihydroflavonol reductase), which was identified as a candidate gene for BoPr. Blast analysis revealed that this 44.8 kb interval is located on an unanchored scaffold (Scaffold000035_P2) of '02-12', confirming the existence of assembly error at the interval between M17 and BoID4714 for reference genome '02-12'. This study identified a candidate gene for BoPr and lays a foundation for the cloning and functional analysis of this gene.

  2. Computer simulation of borates with the use of a universal model of B-O interatomic potentials

    NASA Astrophysics Data System (ADS)

    Eremin, N. N.; Urusov, V. S.

    2013-08-01

    A universal model of the interatomic coupling potentials for structural simulation of borates is developed for correct reproduction and prediction of crystal structures of borates containing BO3 triangles and BO4 tetrahedra. The model is tested on three compounds: CaB2O4, SrB4O7, and CaB6O10. It is concluded that the model can be used in structural simulation and prediction of physical properties of borates containing more complex boron-oxygen radicals.

  3. Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

    DTIC Science & Technology

    2009-04-01

    a disease that is contracted by ingestion of food containing the toxin [1,2], colonization of the bacteria in the gastrointestinal tract of infants...In addition, commer- cially purified BoNT/A1 (strain Hall) and BoNT/A2 (strain FRI- honey ) complex toxins from Metabiologics (Madison, WI) were used

  4. Does Reduction of Number of Intradetrusor Injection Sites of aboBoNTA (Dysport®) Impact Efficacy and Safety in a Rat Model of Neurogenic Detrusor Overactivity?

    PubMed Central

    Huynh Le Maux, Amélie; Pignol, Bernadette; Behr-Roussel, Delphine; Blachon, Jean-Luc; Chabrier, Pierre-Etienne; Compagnie, Sandrine; Picaut, Philippe; Bernabé, Jacques; Giuliano, François; Denys, Pierre

    2015-01-01

    Intradetrusor injections of Botulinum toxin A—currently onabotulinumtoxinA—is registered as a second-line treatment to treat neurogenic detrusor overactivity (NDO). The common clinical practice is 30 × 1 mL injections in the detrusor; however, protocols remain variable and standardization is warranted. The effect of reducing the number of injection sites of Dysport® abobotulinumtoxinA (aboBoNTA) was assessed in the spinal cord-injured rat (SCI). Nineteen days post-spinalization, female rats received intradetrusor injections of saline or aboBoNTA 22.5 U distributed among four or eight sites. Two days after injection, continuous cystometry was performed in conscious rats. Efficacy of aboBoNTA 22.5 U was assessed versus aggregated saline groups on clinically-relevant parameters: maximal pressure, bladder capacity, compliance, voiding efficiency, as well as amplitude, frequency, and volume threshold for nonvoiding contractions (NVC). AboBoNTA 22.5 U significantly decreased maximal pressure, without affecting voiding efficiency. Injected in four sites, aboBoNTA significantly increased bladder capacity and compliance while only the latter when in eight sites. AboBoNTA significantly reduced NVC frequency and amplitude. This preclinical investigation showed similar inhibiting effects of aboBoNTA despite the number of sites reduction. Further studies are warranted to optimize dosing schemes to improve the risk-benefit ratio of BoNTA-based treatment modalities for NDO and further idiopathic overactive bladder. PMID:26694464

  5. 40 CFR 721.1731 - Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1731 Section 721.1731 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric...

  6. 40 CFR 721.1730 - Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1730 Section 721.1730 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric...

  7. Extraction of BoNT/A, /B, /E, and /F with a Single, High Affinity Monoclonal Antibody for Detection of Botulinum Neurotoxin by Endopep-MS

    PubMed Central

    Kalb, Suzanne R.; Garcia-Rodriguez, Consuelo; Lou, Jianlong; Baudys, Jakub; Smith, Theresa J.; Marks, James D.; Smith, Leonard A.; Pirkle, James L.; Barr, John R.

    2010-01-01

    Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing respiratory failure leading to long-term intensive care or death. The best treatment for botulism includes serotype-specific antitoxins, which are most effective when administered early in the course of the intoxication. Early confirmation of human exposure to any serotype of BoNT is an important public health goal. In previous work, we focused on developing Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating the seven serotypes (BoNT/A-G) in buffer and BoNT/A, /B, /E, and /F (the four serotypes that commonly affect humans) in clinical samples. We have previously reported the success of antibody-capture to purify and concentrate BoNTs from complex matrices, such as clinical samples. However, to check for any one of the four serotypes of BoNT/A, /B, /E, or /F, each sample is split into 4 aliquots, and tested for the specific serotypes separately. The discovery of a unique monoclonal antibody that recognizes all four serotypes of BoNT/A, /B, /E and /F allows us to perform simultaneous detection of all of them. When applied in conjunction with the Endopep-MS assay, the detection limit for each serotype of BoNT with this multi-specific monoclonal antibody is similar to that obtained when using other serotype-specific antibodies. PMID:20808925

  8. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO3), mixed esters with... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol... NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1729 Boric...

  9. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Boric acid (H3BO3), mixed esters with... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol... NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1729 Boric...

  10. 40 CFR 721.1730 - Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1730 Section 721.1730 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric...

  11. 40 CFR 721.1731 - Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric acid (H3BO3).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1731 Section 721.1731 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric...

  12. Genetic analysis, expression and molecular characterization of BoGSL-ELONG, a major gene involved in the aliphatic glucosinolate pathway of Brassica species.

    PubMed Central

    Li, Genyi; Quiros, Carlos F

    2002-01-01

    We cloned a major aliphatic glucosinolate (GSL) gene, BoGSL-ELONG in Brassica oleracea, using the Arabidopsis sequence database. We based our work on an Arabidopsis candidate gene forming part of a gene family coding for isopropyl malate synthetase-like enzymes (IPMS). This gene is presumably responsible for synthesis of GSL possessing side chains consisting of four carbons (4C). The similarity of the Brassica homolog IPMS-Bo from broccoli to its Arabidopsis counterpart IPMS-At was on the order of 78%, both sharing the same number of exons. A nonfunctional allele of the BoGSL-ELONG gene from white cauliflower, based on the absence of 4C GSL in this crop, displayed a 30-bp deletion, which allowed us to develop a codominant marker for 4C-GSL. Gene expression analysis based on RT-PCR revealed a splicing site mutation in the white cauliflower allele. This resulted in a longer transcript containing intron 3, which failed to excise. Perfect cosegregation was observed for broccoli and cauliflower alleles at the IPMS-Bo gene and 4C-GSL content, strongly indicating that this gene indeed corresponds to BoGSL-ELONG. Cloning of two other major genes, BoGSL-ALK and BoGSL-PRO, is underway. The availability of these genes and BoGSL-ELONG is essential for the manipulation of the aliphatic GSL profile of B. oleracea. PMID:12524361

  13. Novel topical BoNTA (CosmeTox, toxin type A) cream used to treat hyperfunctional wrinkles of the face, mouth, and neck.

    PubMed

    Chajchir, I; Modi, P; Chajchir, A

    2008-09-01

    This study aimed to compare the effect of the stabilized novel topical botulinum neurotoxin type A (BoNTA) cream (CosmeTox) and a placebo cream on subjects, to compare clinician-reported outcomes, and to assess the safety and utility of the novel topical BoNTA cream for treating the entire upper face, chin, and neck areas. This study randomized 40 female subjects to receive either topical BoNTA (CosmeTox) cream (2 U/ml) or an identical placebo cream (without BoNTA) on the face, chin, and neck areas. The subjects were followed for 12 weeks. The main outcome measures were the Facial Line Outcomes questionnaire scores and results from the Self-Perception of Age instrument, which assesses age of appearance relative to actual age. The BoNTA topical cream (CosmeTox) treatment produced significant improvements in the Facial Lines Outcome scores, which were maintained throughout the study period and lasted more than 3 months. The BoNTA topical cream treatment also reduced the age of appearance for a majority of subjects. The placebo had no effect on any measure. No serious adverse events occurred during the entire study period. Topical treatment with the stabilized BoNTA cream (CosmeTox) to the entire upper facial lines resulted in significantly improved facial features and age appearance, as measured by the subjects and clinicians. The BoNTA cream (CosmeTox) resulted in a significantly younger, more satisfying, relaxed appearance.

  14. Determination of the magnetic structure of SmFe3(BO3)4 by neutron diffraction: comparison with other RFe3(BO3)4 iron borates

    NASA Astrophysics Data System (ADS)

    Ritter, C.; Pankrats, A.; Gudim, I.; Vorotynov, A.

    2012-09-01

    Temperature dependent neutron diffraction studies were performed on SmFe3(BO3)4. The crystallographic structure was determined to stay as R32 over the whole studied temperature range of 2 K < T < 300 K. A magnetic phase transition characterized by the magnetic propagation vector κ = [0 0 3/2] takes place at TN = 34 K. The magnetic structure sees an easy-plane arrangement within the trigonal basal a-b-plane of ferromagnetic layers of iron and samarium having a canting angle of about 70° relative to each other. Neighbouring layers in the c-direction are antiferromagnetically coupled; at 2 K the magnetic moment values amount to μFe = 4.2(1) μB and μSm = 0.8(2) μB. The non-Brillouin type increase of the iron magnetic moment below TN points to a strong Fe-Sm exchange and to the simultaneous appearance of long range magnetic order on both sublattices.

  15. BiSr3(YO)3(BO3)4: a new gaudefroyite-type rare-earth borate with moderate SHG response.

    PubMed

    Gao, Jianhua; Li, Shuai

    2012-01-02

    The synthesis, crystal structure, crystal growth, and characterization of a new noncentrosymmetric rare-earth borate BiSr(3)(YO)(3)(BO(3))(4) are reported. BiSr(3)(YO)(3)(BO(3))(4) belongs to gaudefroyite type of structure and crystallizes in the polar hexagonal space group P6(3) (no. 173) with a = 10.6975(16) Å and c = 6.7222(12) Å. In the structure, the YO(7) polyhedra share edges to form an one-dimensional chain along the [001] direction. These chains are interconnected by the BO(3) group to construct a three-dimensional framework, leaving two kinds of channels for Bi atoms and Sr atoms together with BO(3) groups, respectively. On the basis of the powder second-harmonic generation (SHG) measurement, BiSr(3)(YO)(3)(BO(3))(4) belongs to the phase-matchable class with a SHG response of about 3 × KDP.

  16. EPR study of the low-spin state of Ru3+in the YAl3(BO3)4 and EuAl3(BO3)4 aluminum borates

    NASA Astrophysics Data System (ADS)

    Prokhorov, A. A.; Chernush, L. F.; Dyakonov, V. P.; Szymczak, H.; Prokhorov, A. D.

    2016-12-01

    New data on the ground state of impurity Ru3+ ions in the crystals of YAl3(BO3)4 and EuAl3(BO3)4 aluminum borates were obtained. It was shown that Ru3+ ion replaces trivalent rare-earth ions without breaking the symmetry of the site. The crystal field acting on 4d5 ions forms an EPR spectrum, which is described by the spin Hamiltonian with S=1/2. The spin-Hamiltonian parameters determined are equal to gII=1.963, g⊥=3.796, AII=43.03*10-4 cm-1, A⊥=84.86*10-4 cm-1 in the YAl3(BO3)4 crystal (at T=15 K) and gII=2.016, g⊥=3.796 in the EuAl3(BO3)4 crystal (at T=15 K). It is found that the value of ∆g=gII-g⊥ is an indicator of distortions of nearest environment of Ru3+ ion. The angle between the C3 axis and the direction into nearest oxygen ion was determined. The EPR linewidth of Ru3+ ion increases with increasing temperature due to the dipole-dipole and exchange interactions with the excited states of the host lattice Ru3+ ion.

  17. Redescription of Trypanosoma ophiocephali Chen 1964 (Kinetoplastida: Trypanosomatina: Trypanosomatidae) and first record from the blood of dark sleeper (Odontobutis obscura Temminck and Schlegel) in China.

    PubMed

    Gu, Zemao; Wang, Jianguo; Zhang, Jinyong; Gong, Xiaoning

    2006-12-01

    During the parasite fauna investigation within 2004 and 2005, the freshwater fish trypanosomes were isolated from the blood of dark sleeper (Odontobutis obscura Temminck and Schlegel) and snakehead fish (Ophiocephalus argus Cantor) from Niushan Lake, Hubei Province, China. Blood trypomastigotes were used for light microscopy investigations. The detailed descriptions of three morphological groups of the genus Trypanosoma: Trypanosoma sp. I and Trypanosoma sp. II found in blood of O. obscura, and Trypanosoma sp. III found in blood of O. argus were provided. Morphological features and host species show Trypanosoma sp. III belong to Trypanosoma ophiocephali Chen 1964, an incompletely described species. Infection with trypanosomes of O. obscura was recorded for the first time. According to the size and appearance, the trypanosomes in O. obscura were also tentatively identified as T. ophiocephali Chen 1964.

  18. Characterization of BoHV-5 field strains circulation and report of transient specific subtype of bovine herpesvirus 5 in Argentina

    PubMed Central

    2011-01-01

    Background Bovine herpesvirus 5 (BoHV-5) is a member of the subfamily Alphaherpesvirinae responsible for meningo-encephalitis in young cattle. The first case of bovine meningo-encephalitis associated with a herpesvirus infection was reported in Australia. The current geographical distribution of BoHV-5 infection is mainly restricted to South America, especially Brazil and Argentina. Outbreaks of BoHV-5 are regularly observed in Argentina suggesting the circulation of the virus in the bovine population. Results Seventeen field strains of BoHV-5 isolated from 1984 to now were confirmed by differential PCR and subjected to restriction endonuclease analysis (REA). Viral DNA was cleaved with BstEII which allows the differentiation among subtypes a, b and non a, non b. According to the REA with BstEII, only one field strain showed a pattern similar to the Argentinean A663 strain (prototype of BoHV-5b). All other isolates showed a clear pattern similar to the Australian N569 strain (prototype of BoHV-5a) consistent with the subtypes observed in Brazil, the other South-American country where BoHV-5 is known to be prevalent. The genomic region of subtype b responsible for the distinct pattern was determined and amplified by PCR; specifically a point mutation was identified in glycoprotein B gene, on the BstEII restriction site, which generates the profile specific of BoHV-5b. Conclusions This is the first report of circulation of BoHV-5a in Argentina as the prevailing subtype. Therefore the circulation of BoHV-5b was restricted to a few years in Argentina, speculating that this subtype was not able to be maintained in the bovine population. The mutation in the gB gene is associated with the difference in the restriction patterns between subtypes "a" and "b". PMID:21299866

  19. Two genera of Braconinae (Hymenoptera, Braconidae) in China, with descriptions of four new species

    PubMed Central

    Wang, Yi-Ping; Chen, Xue-Xin; Wu, Hong; He, Jun-Hua

    2010-01-01

    Abstract Two genera, namely Dolabraulax Quicke and Scutibracon Quicke of Braconinae (Hymenoptera: Braconidae) from China are studied for the first time, and four new species, namely Dolabraulax jigongshanus Wang & Chen, sp. n., Dolabraulax flavus Wang & Chen, sp. n., Dolabraulax brevivena Wang & Chen, sp. n. and Scutibracon fujianensis Wang & Chen, sp. n. are fully described and illustrated. The examined specimens are deposited in the Parasitic Hymenoptera Collection, Zhejiang University, Hangzhou, China (ZJUH). PMID:21594015

  20. A description of preimaginal stages of Pseudaspidapion botanicum Alonso-Zarazaga & Wang, 2011 (Apionidae, Curculionoidea)

    PubMed Central

    Wang, Zhiliang; Alonso-Zarazaga, M. A.; Zhou, Dakang; Zhang, Runzhi

    2013-01-01

    Abstract The preimaginal stages including egg, mature larva and pupa of Pseudaspidapion botanicum Alonso-Zarazaga & Wang, 2011 were described and figured, diagnostic characters of larva and pupa were discussed, and corresponding biological information was supplied. The nomenclature of frontal setae in the larva compared with curculionid weevils, the absence of the hypopharyngeal bracon in the larva, and the metafemoral setae in the pupa were discussed. Common and different characters among the larvae of Pseudaspidapion botanicum, Aspidapion radiolus (Marsham, 1802) and Aspidapion aeneum (Fabricius, 1775) were also provided. PMID:23653504

  1. A description of preimaginal stages of Pseudaspidapion botanicum Alonso-Zarazaga & Wang, 2011 (Apionidae, Curculionoidea).

    PubMed

    Wang, Zhiliang; Alonso-Zarazaga, M A; Zhou, Dakang; Zhang, Runzhi

    2013-01-01

    The preimaginal stages including egg, mature larva and pupa of Pseudaspidapion botanicum Alonso-Zarazaga & Wang, 2011 were described and figured, diagnostic characters of larva and pupa were discussed, and corresponding biological information was supplied. The nomenclature of frontal setae in the larva compared with curculionid weevils, the absence of the hypopharyngeal bracon in the larva, and the metafemoral setae in the pupa were discussed. Common and different characters among the larvae of Pseudaspidapion botanicum, Aspidapion radiolus (Marsham, 1802) and Aspidapion aeneum (Fabricius, 1775) were also provided.

  2. Critical endpoint behavior in an asymmetric Ising model: application of Wang-Landau sampling to calculate the density of states.

    PubMed

    Tsai, Shan-Ho; Wang, Fugao; Landau, D P

    2007-06-01

    Using the Wang-Landau sampling method with a two-dimensional random walk we determine the density of states for an asymmetric Ising model with two- and three-body interactions on a triangular lattice, in the presence of an external field. With an accurate density of states we were able to map out the phase diagram accurately and perform quantitative finite-size analyses at, and away from, the critical endpoint. We observe a clear divergence of the curvature of the spectator phase boundary and of the magnetization coexistence diameter derivative at the critical endpoint, and the exponents for both divergences agree well with previous theoretical predictions.

  3. Critical endpoint behavior in an asymmetric Ising model: Application of Wang-Landau sampling to calculate the density of states

    NASA Astrophysics Data System (ADS)

    Tsai, Shan-Ho; Wang, Fugao; Landau, D. P.

    2007-06-01

    Using the Wang-Landau sampling method with a two-dimensional random walk we determine the density of states for an asymmetric Ising model with two- and three-body interactions on a triangular lattice, in the presence of an external field. With an accurate density of states we were able to map out the phase diagram accurately and perform quantitative finite-size analyses at, and away from, the critical endpoint. We observe a clear divergence of the curvature of the spectator phase boundary and of the magnetization coexistence diameter derivative at the critical endpoint, and the exponents for both divergences agree well with previous theoretical predictions.

  4. [Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

    PubMed

    Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

    2014-01-01

    Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

  5. Mesoporous LiFeBO3/C hollow spheres for improved stability lithium-ion battery cathodes

    NASA Astrophysics Data System (ADS)

    Chen, Zhongxue; Cao, Liufei; Chen, Liang; Zhou, Haihui; Zheng, Chunman; Xie, Kai; Kuang, Yafei

    2015-12-01

    Polyanionic compounds are regarded as one of the most promising cathode materials for the next generation lithium-ion batteries due to their abundant resource and thermal stability. LiFeBO3 has a relatively higher capacity than olivine LiFePO4, however, moisture sensitivity and low conductivity hinder its further development. Here, we design and synthesize mesoporous LiFeBO3/C (LFB/C) hollow spheres to enhance its structural stability and electric conductivity, two LiFeBO3/C electrodes with different carbon content are prepared and tested. The experimental results show that mesoporous LiFeBO3/C hollow spheres with higher carbon content exhibit superior lithium storage capacity, cycling stability and rate capability. Particularly, the LFB/C electrode with higher carbon content demonstrates good structural stability, which can maintain its original crystal structure and Li storage properties even after three months of air exposure at room temperature. The exceptional structural stability and electrochemical performance may justify their potential use as high-performance cathode materials for advanced lithium-ion batteries. In addition, the synthesis strategy demonstrated herein is simple and versatile for the fabrication of other polyanionic cathode materials with mesoporous hollow spherical structure.

  6. Unidirectional thermal expansion in edge-sharing BO4 tetrahedra contained KZnB3O6.

    PubMed

    Lou, Yanfang; Li, Dandan; Li, Zhilin; Jin, Shifeng; Chen, Xiaolong

    2015-06-05

    Borates are among a class of compounds that exhibit rich structural diversity and find wide applications. The formation of edge-sharing (es-) BO4 tetrahedra is extremely unfavored according to Pauling's third and fourth rules. However, as the first and the only es-borate obtained under ambient pressure, es-KZnB3O6 shows an unexpected high thermal stability up to its melting point. The origin of this extraordinary stability is still unclear. Here, we report a novel property in KZnB3O6: unidirectional thermal expansion, which plays a role in preserving es-BO4 from disassociation at elevated temperatures. It is found that this unusual thermal behavior originates from cooperative rotations of rigid groups B6O12 and Zn2O6, driven by anharmonic thermal vibrations of K atoms. Furthermore, a detailed calculation of phonon dispersion in association with this unidirectional expansion predicts the melting initiates with the breakage of the link between BO3 and es-BO4. These findings will broaden our knowledge of the relationship between structure and property and may find applications in future.

  7. Luminescence characteristics of Dy3+ activated Na 2Sr 2Mg (BO 3)2F 2: Dy 3+ phosphor

    NASA Astrophysics Data System (ADS)

    Wani, Javaid A.; Dhoble, N. S.; Dhoble, S. J.

    2012-11-01

    In this paper, we have reported a new Na 2Sr 2Mg (BO 3)2F 2:Dy 3+ thermoluminescence (TL) phosphor prepared via the wet chemical method. Prepared phosphor was characterized by X-ray powder diffraction, photoluminescence (PL), TL and scanning electronmicroscopy techniques. The scanning electronmicroscopic image of Na 2Sr 2Mg (BO 3)2F 2:Dy 3+ phosphor confirms the micron size of particles. Under the PL study, the characteristic emission spectrum of Dy 3+ corresponding to 4F 9/2→6H 15/2 (481 nm) and 4F 9/2→6H 13/2 (576 nm) transitions was observed. The TL property of the as prepared phosphor was also found to be good. TL intensity of Na 2Sr2Mg(BO 3)F 2:Dy 3+ phosphors at 0.99 kGy exposure of γ-irradiations was compared with standard CaSO 4:Dy phosphor. It was seen that TL intensity of Na 2Sr 2Mg (BO 3)2F 2: Dy 3+ phosphors is 1.1 times less compared with the standard CaSO 4:Dy TL dosimeter phosphor. The kinetic parameters are also discussed in detail. The values of activation energy E (eV) and frequency factor S (s -1) were found to be 0.57 eV and 1.25×106 s-1, respectively.

  8. Unidirectional thermal expansion in edge-sharing BO4 tetrahedra contained KZnB3O6

    PubMed Central

    Lou, Yanfang; Li, Dandan; Li, Zhilin; Jin, Shifeng; Chen, Xiaolong

    2015-01-01

    Borates are among a class of compounds that exhibit rich structural diversity and find wide applications. The formation of edge-sharing (es-) BO4 tetrahedra is extremely unfavored according to Pauling’s third and fourth rules. However, as the first and the only es-borate obtained under ambient pressure, es-KZnB3O6 shows an unexpected high thermal stability up to its melting point. The origin of this extraordinary stability is still unclear. Here, we report a novel property in KZnB3O6: unidirectional thermal expansion, which plays a role in preserving es-BO4 from disassociation at elevated temperatures. It is found that this unusual thermal behavior originates from cooperative rotations of rigid groups B6O12 and Zn2O6, driven by anharmonic thermal vibrations of K atoms. Furthermore, a detailed calculation of phonon dispersion in association with this unidirectional expansion predicts the melting initiates with the breakage of the link between BO3 and es-BO4. These findings will broaden our knowledge of the relationship between structure and property and may find applications in future. PMID:26047175

  9. Cationic Triarylmethane Photosensitizers For Selective Photochemotherapy: Victoria Blue-Bo, Victoria Blue-R And Malachite Green

    NASA Astrophysics Data System (ADS)

    Wadwa, K.; Smith, S.; Oseroff, A. R.

    1989-03-01

    We have investigated the malignant cell selective phototoxicity of some triarylmethane dyes including Victoria Blue BO (VB-BO), Victoria Blue R (VB-R), and Malachite Green (MG). Phototoxicity was studied in human squamous (FaDu) and colon (CX-1) carcinoma, and in human and murine melanoma (NEL, B-16) cell lines, as well as in non-malignant monkey kidney cells (CV-1). Cultured cells were exposed to varying concentrations of the dyes for 60 min, washed with PBS, irradiated after an efflux time of 90 min in culture media, and placed in a colony forming assay. VB-BO was the most effective photosensitizer, giving 90% killing of malignant cells such as B-16 when treated with 5x10-8 M dye and 13 J/cm2 light. CV-1 cells were unaffected under these conditions. VB-R was about 10 fold less effective, while MG had minimal phototoxicity in this assay. VB-BO was studied in vivo, using subcutaneous FaDu tumors in nude mice. At a dose of 3 mg/kg followed 4 hrs later by dye laser irradiation under conditions which did not produce hyperthermia, there was an 80% complete remission rate without significant phototoxicity to overlying or adjacent normal skin. The triarylmethanes are a novel class of photosensitizers which may have promise in vitro and in vivo.

  10. Distribution of BoLA-DRB3 allelic frequencies and identification of two new alleles in Iranian buffalo breed.

    PubMed

    Mosafer, J; Heydarpour, M; Manshad, E; Russell, G; Sulimova, G E

    2012-01-01

    The role of the major histocompatibility complex (MHC) in the immune response makes it an attractive candidate gene for associations with disease resistance and susceptibility. This study describes genetic variability in the BoLA-DRB3 in Iranian buffaloes. Heminested PCR-RFLP method was used to identify the frequency of BoLA-DRB3 alleles. The BoLA-DRB3 locus is highly polymorphic in the study herd (12 alleles). Almost 63.50% of the alleles were accounted for by four alleles (BoLA-DRB3.2 ∗48, ∗20, ∗21, and obe) in Iranian buffalo. The DRB3.2 ∗48 allele frequency (24.20%) was higher than the others. The frequencies of the DRB3.2 ∗20 and DRB3.2 ∗21 are 14.52 and 14.00, respectively, and obe and gbb have a new pattern. Significant distinctions have been found between Iranian buffalo and other cattle breed studied. In the Iranian buffaloes studied alleles associated with resistance to various diseases are found.

  11. Distribution of BoLA-DRB3 Allelic Frequencies and Identification of Two New Alleles in Iranian Buffalo Breed

    PubMed Central

    Mosafer, J.; Heydarpour, M.; Manshad, E.; Russell, G.; Sulimova, G. E.

    2012-01-01

    The role of the major histocompatibility complex (MHC) in the immune response makes it an attractive candidate gene for associations with disease resistance and susceptibility. This study describes genetic variability in the BoLA-DRB3 in Iranian buffaloes. Heminested PCR-RFLP method was used to identify the frequency of BoLA-DRB3 alleles. The BoLA-DRB3 locus is highly polymorphic in the study herd (12 alleles). Almost 63.50% of the alleles were accounted for by four alleles (BoLA-DRB3.2 ∗48, ∗20, ∗21, and obe) in Iranian buffalo. The DRB3.2 ∗48 allele frequency (24.20%) was higher than the others. The frequencies of the DRB3.2 ∗20 and DRB3.2 ∗21 are 14.52 and 14.00, respectively, and obe and gbb have a new pattern. Significant distinctions have been found between Iranian buffalo and other cattle breed studied. In the Iranian buffaloes studied alleles associated with resistance to various diseases are found. PMID:22454612

  12. The signature of orbital motion from the dayside of the planet τ Boötis b.

    PubMed

    Brogi, Matteo; Snellen, Ignas A G; de Kok, Remco J; Albrecht, Simon; Birkby, Jayne; de Mooij, Ernst J W

    2012-06-27

    The giant planet orbiting τ Boötis (named τ Boötis b) was amongst the first extrasolar planets to be discovered. It is one of the brightest exoplanets and one of the nearest to us, with an orbital period of just a few days. Over the course of more than a decade, measurements of its orbital inclination have been announced and refuted, and have hitherto remained elusive. Here we report the detection of carbon monoxide absorption in the thermal dayside spectrum of τ Boötis b. At a spectral resolution of ∼100,000, we trace the change in the radial velocity of the planet over a large range in phase, determining an orbital inclination of 44.5° ± 1.5° and a mass 5.95 ± 0.28 times that of Jupiter, demonstrating that atmospheric characterization is possible for non-transiting planets. The strong absorption signal points to an atmosphere with a temperature that is decreasing towards higher altitudes, in contrast to the temperature inversion inferred for other highly irradiated planets. This supports the hypothesis that the absorbing compounds believed to cause such atmospheric inversions are destroyed in τ Boötis b by the ultraviolet emission from the active host star.

  13. Unidirectional thermal expansion in edge-sharing BO4 tetrahedra contained KZnB3O6

    NASA Astrophysics Data System (ADS)

    Lou, Yanfang; Li, Dandan; Li, Zhilin; Jin, Shifeng; Chen, Xiaolong

    2015-06-01

    Borates are among a class of compounds that exhibit rich structural diversity and find wide applications. The formation of edge-sharing (es-) BO4 tetrahedra is extremely unfavored according to Pauling’s third and fourth rules. However, as the first and the only es-borate obtained under ambient pressure, es-KZnB3O6 shows an unexpected high thermal stability up to its melting point. The origin of this extraordinary stability is still unclear. Here, we report a novel property in KZnB3O6: unidirectional thermal expansion, which plays a role in preserving es-BO4 from disassociation at elevated temperatures. It is found that this unusual thermal behavior originates from cooperative rotations of rigid groups B6O12 and Zn2O6, driven by anharmonic thermal vibrations of K atoms. Furthermore, a detailed calculation of phonon dispersion in association with this unidirectional expansion predicts the melting initiates with the breakage of the link between BO3 and es-BO4. These findings will broaden our knowledge of the relationship between structure and property and may find applications in future.

  14. Evidence for a Key Role of Cytochrome bo3 Oxidase in Respiratory Energy Metabolism of Gluconobacter oxydans

    PubMed Central

    Richhardt, Janine; Luchterhand, Bettina; Büchs, Jochen

    2013-01-01

    The obligatory aerobic acetic acid bacterium Gluconobacter oxydans oxidizes a variety of substrates in the periplasm by membrane-bound dehydrogenases, which transfer the reducing equivalents to ubiquinone. Two quinol oxidases, cytochrome bo3 and cytochrome bd, then catalyze transfer of the electrons from ubiquinol to molecular oxygen. In this study, mutants lacking either of these terminal oxidases were characterized. Deletion of the cydAB genes for cytochrome bd had no obvious influence on growth, whereas the lack of the cyoBACD genes for cytochrome bo3 severely reduced the growth rate and the cell yield. Using a respiration activity monitoring system and adjusting different levels of oxygen availability, hints of a low-oxygen affinity of cytochrome bd oxidase were obtained, which were supported by measurements of oxygen consumption in a respirometer. The H+/O ratio of the ΔcyoBACD mutant with mannitol as the substrate was 0.56 ± 0.11 and more than 50% lower than that of the reference strain (1.26 ± 0.06) and the ΔcydAB mutant (1.31 ± 0.16), indicating that cytochrome bo3 oxidase is the main component for proton extrusion via the respiratory chain. Plasmid-based overexpression of cyoBACD led to increased growth rates and growth yields, both in the wild type and the ΔcyoBACD mutant, suggesting that cytochrome bo3 might be a rate-limiting factor of the respiratory chain. PMID:23852873

  15. Beryllium-free Li4Sr(BO3)2 for deep-ultraviolet nonlinear optical applications.

    PubMed

    Zhao, Sangen; Gong, Pifu; Bai, Lei; Xu, Xiang; Zhang, Shuquan; Sun, Zhihua; Lin, Zheshuai; Hong, Maochun; Chen, Chuangtian; Luo, Junhua

    2014-05-29

    Nonlinear optical (NLO) materials are of great importance in laser science and technology, as they can expand the wavelength range provided by common laser sources. Few NLO materials, except KBe2BO3F2 (KBBF), can practically generate deep-ultraviolet coherent light by direct second-harmonic generation process, limited by the fundamental requirements on the structure-directing optical properties. However, KBBF suffers a strong layering tendency and high toxicity of the containing beryllium, which hinder the commercial availability of KBBF. Here we report a new beryllium-free borate, Li4Sr(BO3)2, which preserves the structural merits of KBBF, resulting in the desirable optical properties. Furthermore, Li4Sr(BO3)2 mitigates the layering tendency greatly and enhances the efficiency of second-harmonic generation by more than half that of KBBF. These results suggest that Li4Sr(BO3)2 is an attractive candidate for the next generation of deep-ultraviolet NLO materials. This beryllium-free borate represents a new research direction in the development of deep-ultraviolet NLO materials.

  16. Beryllium-free Li4Sr(BO3)2 for deep-ultraviolet nonlinear optical applications

    NASA Astrophysics Data System (ADS)

    Zhao, Sangen; Gong, Pifu; Bai, Lei; Xu, Xiang; Zhang, Shuquan; Sun, Zhihua; Lin, Zheshuai; Hong, Maochun; Chen, Chuangtian; Luo, Junhua

    2014-05-01

    Nonlinear optical (NLO) materials are of great importance in laser science and technology, as they can expand the wavelength range provided by common laser sources. Few NLO materials, except KBe2BO3F2 (KBBF), can practically generate deep-ultraviolet coherent light by direct second-harmonic generation process, limited by the fundamental requirements on the structure-directing optical properties. However, KBBF suffers a strong layering tendency and high toxicity of the containing beryllium, which hinder the commercial availability of KBBF. Here we report a new beryllium-free borate, Li4Sr(BO3)2, which preserves the structural merits of KBBF, resulting in the desirable optical properties. Furthermore, Li4Sr(BO3)2 mitigates the layering tendency greatly and enhances the efficiency of second-harmonic generation by more than half that of KBBF. These results suggest that Li4Sr(BO3)2 is an attractive candidate for the next generation of deep-ultraviolet NLO materials. This beryllium-free borate represents a new research direction in the development of deep-ultraviolet NLO materials.

  17. Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower

    USDA-ARS?s Scientific Manuscript database

    Purple cauliflower (Brassica oleracea L. var. botrytis) Graffiti represents a unique mutant in conferring ectopic anthocyanin biosynthesis, which is caused by the tissue specific activation of BoMYB2, an ortholog of Arabidopsis PAP2 or MYB113. To gain a better understanding of the regulatory network...

  18. Variation in foraging behavior and body mass in broods of Emperor Geese (Chen canagica): Evidence for interspecific density dependence

    USGS Publications Warehouse

    Schmutz, J.A.; Laing, K.K.

    2002-01-01

    Broods of geese spend time feeding according to availability and quality of food plants, subject to inherent foraging and digestive constraints. We studied behavioral patterns of broods of Emperor Geese (Chen canagica) on the Yukon–Kuskokwim Delta, Alaska, and examined how feeding and alert behavior varied in relation to habitat and goose density. During 1994–1996, time spent feeding by Emperor Goose goslings and adult females was positively related to multispecies goose densities near observation blinds, and not to just Emperor Goose density. Similarly, body mass of Emperor Goose goslings was more strongly related (negatively) to multispecies goose densities than intraspecific densities. A grazing experiment in 1995 indicated that most above ground primary production by Carex subspathacea, a preferred food plant, was consumed by grazing geese. Those results demonstrate that interspecific competition for food occurred, with greatest support for goslings whose behavioral repertoire is limited primarily to feeding, digesting, and resting. Although the more abundant Cackling Canada Geese (Branta canadensis minima) differed from Emperor Geese in their preferred use of habitats during brooding rearing (Schmutz 2001), the two species occurred in equal abundance in habitats preferred by Emperor Goose broods. Thus, Cackling Canada Geese were a numerically significant competitor with Emperor Geese. Comparing these results to an earlier study, time spent feeding by goslings, adult females, and adult males were greater during 1993–1996 than during 1985–1986. During the interval between those studies, densities of Cackling Canada Geese increased two to three times whereas Emperor Goose numbers remained approximately stable, which implies that interspecific competition affected foraging behavior over a long time period. These density-dependent changes in foraging behavior and body mass indicate that interspecific competition affects nutrient acquisition and gosling

  19. Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction

    PubMed Central

    Xiang, Hong; Wang, Guijun; Qu, Jialin; Xia, Shilin; Tao, Xufeng; Qi, Bing; Zhang, Qingkai; Shang, Dong

    2016-01-01

    Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has a long history of clinical use in China for the treatment of inflammatory diseases. However, the efficacy and mechanisms of YCHT for the treatment of severe acute pancreatitis (SAP) are not known. The current study investigated the pharmacological properties of YCHT against SAP and its underlying mechanisms. A computational prediction of potential targets of YCHT was initially established based on a network pharmacology simulation. The model suggested that YCHT attenuated SAP progress by apoptosis inducement, anti-inflammation, anti-oxidation and blood lipid regulation. These effects were validated in SAP rats. YCHT administration produced the following results: (1) significantly inhibited the secretion of pancreatic enzymes and protected pancreatic tissue; (2) obviously increased the number of in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells and induced apoptosis; (3) markedly inhibited neutrophil infiltration to the impaired pancreas and reduced the inflammatory reaction; (4) notably enhanced the activities of antioxidant enzymes and decreased the nitric oxide synthase levels; (5) significantly reduced the levels of triglycerides, total cholesterol and low-density lipoprotein and increased high-density lipoprotein; and (6) significantly up-regulated peroxisome proliferator-activated receptor-γ (PPARγ) and down-regulated nuclear factor-kappa B (NF-κB). In summary, these results demonstrated that YCHT attenuated SAP progress by inducing apoptosis, repressing inflammation, alleviating oxidative stress and regulating lipid metabolism partially via regulation of the NF-κB/PPARγ signal pathway. PMID:27790147

  20. Cascade de photons dans les boîtes quantiques uniques

    NASA Astrophysics Data System (ADS)

    Robert, I.; Moreau, E.; Gérard, J. M.; Abram, I.

    2002-06-01

    Nous présentons l'observation expérimentale de l'émission squentielle de photons par une boîte quantique unique sous pompage optique continu ou pulsé. Cette cascade radiative produit des paires de photons corrélés qui sont émis suivant un ordre bien défini. En effet, la fonction de corrélation croisée entre les deux photons formant la paire présente une allure asymétrique, de type groupement ou dégroupement de photons, suivant l'ordre temporel de détection des deux photons. Prédit théoriquement en physique atomique, ce comportement asymétrique de la fonction de corrélation de second ordre est la signature de l'émission successive de photons.