Sample records for bohrium 261

  1. Road dust and its effect on human health: a literature review

    PubMed Central

    2018-01-01

    The purpose of this study was to determine the effects of road dust on human health. A PubMed search was used to extract references that included the words “road dust” and “health” or “fugitive dust” and “health” in the title or abstract. A total of 46 references were extracted and selected for review after the primary screening of 949 articles. The respiratory system was found to be the most affected system in the human body. Lead, platinum-group elements (platinum, rhodium, and bohrium), aluminum, zinc, vanadium, and polycyclic aromatic hydrocarbons were the components of road dust that were most frequently referenced in the articles reviewed. Road dust was found to have harmful effects on the human body, especially on the respiratory system. To determine the complex mechanism of action of various components of road dust on the human body and the results thereof, the authors recommend a further meta-analysis and extensive risk-assessment research into the health impacts of dust exposure. PMID:29642653

  2. Comparative Effect of an Addition of a Surface Term to Woods-Saxon Potential on Thermodynamics of a Nucleon

    NASA Astrophysics Data System (ADS)

    Lütfüoğlu, B. C.

    2018-01-01

    In this study, we reveal the difference between Woods-Saxon (WS) and Generalized Symmetric Woods-Saxon (GSWS) potentials in order to describe the physical properties of a nucleon, by means of solving Schrödinger equation for the two potentials. The additional term squeezes the WS potential well, which leads an upward shift in the spectrum, resulting in a more realistic picture. The resulting GSWS potential does not merely accommodate extra quasi bound states, but also has modified bound state spectrum. As an application, we apply the formalism to a real problem, an α particle confined in Bohrium-270 nucleus. The thermodynamic functions Helmholtz energy, entropy, internal energy, specific heat of the system are calculated and compared for both wells. The internal energy and the specific heat capacity increase as a result of upward shift in the spectrum. The shift of the Helmholtz free energy is a direct consequence of the shift of the spectrum. The entropy decreases because of a decrement in the number of available states. Supported by the Turkish Science and Research Council (TÜBİTAK) and Akdeniz University

  3. 12 CFR 261a.12 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Exceptions. 261a.12 Section 261a.12 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES... Individual to Whom Record Pertains § 261a.12 Exceptions. The restrictions on disclosure in § 261a.11 of this...

  4. 12 CFR 261a.4 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Fees. 261a.4 Section 261a.4 Banks and Banking... TO PERSONAL INFORMATION UNDER THE PRIVACY ACT OF 1974 General Provisions § 261a.4 Fees. (a) Copies of... Availability of Information, § 261.10 of this part. (b) No fee. Documents may be furnished without charge where...

  5. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  6. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  7. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  8. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  9. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  10. 18 CFR 284.261 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Emergency Natural Gas Sale, Transportation, and Exchange Transactions § 284.261 Purpose. This subpart... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Purpose. 284.261 Section 284.261 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT...

  11. 40 CFR 98.261 - Reporting threshold.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Reporting threshold. 98.261 Section 98.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.261 Reporting threshold. You must report...

  12. 40 CFR 98.261 - Reporting threshold.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Reporting threshold. 98.261 Section 98.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.261 Reporting threshold. You must report...

  13. 36 CFR 261.4 - Disorderly conduct.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Disorderly conduct. 261.4 Section 261.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.4 Disorderly conduct. The following are prohibited: (a) Engaging in fighting...

  14. 12 CFR 261.10 - Published information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Published information. 261.10 Section 261.10... RULES REGARDING AVAILABILITY OF INFORMATION Published Information and Records Available to Public; Procedures for Requests § 261.10 Published information. (a) Federal Register. The Board publishes in the...

  15. 10 CFR 26.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Purpose. 26.1 Section 26.1 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.1 Purpose. This part prescribes requirements and standards for the establishment, implementation, and maintenance of fitness-for-duty (FFD...

  16. 10 CFR 26.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Purpose. 26.1 Section 26.1 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.1 Purpose. This part prescribes requirements and standards for the establishment, implementation, and maintenance of fitness-for-duty (FFD...

  17. 10 CFR 26.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Purpose. 26.1 Section 26.1 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.1 Purpose. This part prescribes requirements and standards for the establishment, implementation, and maintenance of fitness-for-duty (FFD...

  18. 10 CFR 26.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Purpose. 26.1 Section 26.1 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.1 Purpose. This part prescribes requirements and standards for the establishment, implementation, and maintenance of fitness-for-duty (FFD...

  19. 10 CFR 26.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Purpose. 26.1 Section 26.1 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.1 Purpose. This part prescribes requirements and standards for the establishment, implementation, and maintenance of fitness-for-duty (FFD...

  20. 40 CFR 261.9 - Requirements for Universal Waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Requirements for Universal Waste. 261.9 Section 261.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.9 Requirements for Universal Waste...

  1. 46 CFR 107.261 - Drydock or special examination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Drydock or special examination. 107.261 Section 107.261 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS INSPECTION AND CERTIFICATION Inspection and Certification § 107.261 Drydock or special examination. (a...

  2. 46 CFR 107.261 - Drydock or special examination.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Drydock or special examination. 107.261 Section 107.261 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS INSPECTION AND CERTIFICATION Inspection and Certification § 107.261 Drydock or special examination. (a...

  3. 46 CFR 107.261 - Drydock or special examination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Drydock or special examination. 107.261 Section 107.261 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS INSPECTION AND CERTIFICATION Inspection and Certification § 107.261 Drydock or special examination. (a...

  4. 46 CFR 107.261 - Drydock or special examination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Drydock or special examination. 107.261 Section 107.261 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS INSPECTION AND CERTIFICATION Inspection and Certification § 107.261 Drydock or special examination. (a...

  5. 46 CFR 107.261 - Drydock or special examination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Drydock or special examination. 107.261 Section 107.261 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS INSPECTION AND CERTIFICATION Inspection and Certification § 107.261 Drydock or special examination. (a...

  6. 36 CFR 261.20 - Pacific Crest National Scenic Trail.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Trail. 261.20 Section 261.20 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.20 Pacific Crest National Scenic Trail. It is prohibited to use a motorized vehicle on the Pacific Crest National Scenic Trail without a special-use...

  7. 40 CFR 261.10 - Criteria for identifying the characteristics of hazardous waste.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... characteristics of hazardous waste. 261.10 Section 261.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Criteria for Identifying the Characteristics of Hazardous Waste and for Listing Hazardous Waste § 261.10 Criteria for...

  8. 40 CFR 261.10 - Criteria for identifying the characteristics of hazardous waste.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... characteristics of hazardous waste. 261.10 Section 261.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Criteria for Identifying the Characteristics of Hazardous Waste and for Listing Hazardous Waste § 261.10 Criteria for...

  9. 40 CFR 261.10 - Criteria for identifying the characteristics of hazardous waste.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... characteristics of hazardous waste. 261.10 Section 261.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Criteria for Identifying the Characteristics of Hazardous Waste and for Listing Hazardous Waste § 261.10 Criteria for...

  10. 40 CFR 261.10 - Criteria for identifying the characteristics of hazardous waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... characteristics of hazardous waste. 261.10 Section 261.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Criteria for Identifying the Characteristics of Hazardous Waste and for Listing Hazardous Waste § 261.10 Criteria for...

  11. 40 CFR 261.10 - Criteria for identifying the characteristics of hazardous waste.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... characteristics of hazardous waste. 261.10 Section 261.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Criteria for Identifying the Characteristics of Hazardous Waste and for Listing Hazardous Waste § 261.10 Criteria for...

  12. 36 CFR 261.21 - National Forest primitive areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest primitive areas. 261.21 Section 261.21 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.21 National Forest primitive areas. The following are...

  13. 36 CFR 261.18 - National Forest Wilderness.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest Wilderness. 261.18 Section 261.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.18 National Forest Wilderness. The following are prohibited in a...

  14. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy of...

  15. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy of...

  16. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy of...

  17. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy of...

  18. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy of...

  19. 10 CFR 431.261 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 431.261 Section 431.261 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Commercial Prerinse Spray Valves § 431.261 Purpose and scope. This subpart contains energy...

  20. 36 CFR 261.7 - Livestock.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Livestock. 261.7 Section 261... Prohibitions § 261.7 Livestock. The following are prohibited: (a) Placing or allowing unauthorized livestock to... unauthorized livestock from the National Forest System or other lands under Forest Service control when...

  1. 39 CFR 261.3 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Policy. 261.3 Section 261.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.3 Policy. It is the policy of the Postal Service: (a) To, as appropriate, create, preserve, protect and...

  2. 39 CFR 261.2 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Authority. 261.2 Section 261.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.2.... Included is the authority to issue records management policy and to delegate or take appropriate action if...

  3. 39 CFR 261.3 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Policy. 261.3 Section 261.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.3 Policy. It is the policy of the Postal Service: (a) To, as appropriate, create, preserve, protect and...

  4. 39 CFR 261.3 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Policy. 261.3 Section 261.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.3 Policy. It is the policy of the Postal Service: (a) To, as appropriate, create, preserve, protect and...

  5. 39 CFR 261.3 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Policy. 261.3 Section 261.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.3 Policy. It is the policy of the Postal Service: (a) To, as appropriate, create, preserve, protect and...

  6. 39 CFR 261.2 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Authority. 261.2 Section 261.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.2.... Included is the authority to issue records management policy and to delegate or take appropriate action if...

  7. 39 CFR 261.2 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Authority. 261.2 Section 261.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.2.... Included is the authority to issue records management policy and to delegate or take appropriate action if...

  8. 39 CFR 261.2 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Authority. 261.2 Section 261.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.2.... Included is the authority to issue records management policy and to delegate or take appropriate action if...

  9. 39 CFR 261.3 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Policy. 261.3 Section 261.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.3 Policy. It is the policy of the Postal Service: (a) To, as appropriate, create, preserve, protect and...

  10. 39 CFR 261.2 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Authority. 261.2 Section 261.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.2.... Included is the authority to issue records management policy and to delegate or take appropriate action if...

  11. 40 CFR 97.261 - EPA recordation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false EPA recordation. 97.261 Section 97.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Transfers § 97.261 EPA...

  12. 40 CFR 97.261 - EPA recordation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false EPA recordation. 97.261 Section 97.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Transfers § 97.261 EPA...

  13. 40 CFR 96.261 - EPA recordation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false EPA recordation. 96.261 Section 96.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET... Transfers § 96.261 EPA recordation. (a) Within 5 business days (except as necessary to perform a transfer in...

  14. 40 CFR 97.261 - EPA recordation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false EPA recordation. 97.261 Section 97.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Transfers § 97.261 EPA...

  15. 40 CFR 96.261 - EPA recordation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false EPA recordation. 96.261 Section 96.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET... Transfers § 96.261 EPA recordation. (a) Within 5 business days (except as necessary to perform a transfer in...

  16. 40 CFR 96.261 - EPA recordation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false EPA recordation. 96.261 Section 96.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET... Transfers § 96.261 EPA recordation. (a) Within 5 business days (except as necessary to perform a transfer in...

  17. 40 CFR 97.261 - EPA recordation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false EPA recordation. 97.261 Section 97.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Transfers § 97.261 EPA...

  18. 40 CFR 96.261 - EPA recordation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false EPA recordation. 96.261 Section 96.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET... Transfers § 96.261 EPA recordation. (a) Within 5 business days (except as necessary to perform a transfer in...

  19. 21 CFR 558.261 - Florfenicol.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Florfenicol. 558.261 Section 558.261 Food and... in Animal Feeds § 558.261 Florfenicol. (a) Specifications. Type A medicated articles containing florfenicol in the following concentrations: (1) 40 grams per kilogram for use as in paragraph (e)(1) of this...

  20. 21 CFR 558.261 - Florfenicol.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Florfenicol. 558.261 Section 558.261 Food and... in Animal Feeds § 558.261 Florfenicol. (a) Specifications. Type A medicated articles containing florfenicol in the following concentrations: (1) 40 grams per kilogram for use as in paragraph (e)(1) of this...

  1. 46 CFR 199.261 - Survival craft.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft. 199.261 Section 199.261 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Cargo Vessels § 199.261 Survival craft. (a) Each survival craft must be approved and equipped as follows: (1) Each lifeboat must be a totally...

  2. 40 CFR 261.151 - Wording of the instruments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Wording of the instruments. 261.151 Section 261.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Financial Requirements for Management of Excluded Hazardous Secondary Materials § 261.151...

  3. 40 CFR 261.151 - Wording of the instruments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Wording of the instruments. 261.151 Section 261.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Financial Requirements for Management of Excluded Hazardous Secondary Materials § 261.151...

  4. 36 CFR 261.57 - National Forest wilderness.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false National Forest wilderness. 261.57 Section 261.57 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.57 National Forest wilderness. When provided by an...

  5. 36 CFR 261.57 - National Forest wilderness.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false National Forest wilderness. 261.57 Section 261.57 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.57 National Forest wilderness. When provided by an...

  6. 36 CFR 261.57 - National Forest wilderness.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false National Forest wilderness. 261.57 Section 261.57 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.57 National Forest wilderness. When provided by an...

  7. 36 CFR 261.57 - National Forest wilderness.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false National Forest wilderness. 261.57 Section 261.57 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.57 National Forest wilderness. When provided by an...

  8. 36 CFR 261.57 - National Forest wilderness.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest wilderness. 261.57 Section 261.57 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.57 National Forest wilderness. When provided by an...

  9. 36 CFR 261.8 - Fish and wildlife.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Fish and wildlife. 261.8 Section 261.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.8 Fish and wildlife. The following are prohibited to the extent Federal or...

  10. 36 CFR 261.8 - Fish and wildlife.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Fish and wildlife. 261.8 Section 261.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.8 Fish and wildlife. The following are prohibited to the extent Federal or...

  11. 36 CFR 261.8 - Fish and wildlife.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Fish and wildlife. 261.8 Section 261.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.8 Fish and wildlife. The following are prohibited to the extent Federal or...

  12. 36 CFR 261.8 - Fish and wildlife.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Fish and wildlife. 261.8 Section 261.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.8 Fish and wildlife. The following are prohibited to the extent Federal or...

  13. 36 CFR 261.8 - Fish and wildlife.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Fish and wildlife. 261.8 Section 261.8 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.8 Fish and wildlife. The following are prohibited to the extent Federal or...

  14. 40 CFR 261.7 - Residues of hazardous waste in empty containers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Residues of hazardous waste in empty containers. 261.7 Section 261.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.7 Residues of hazardous...

  15. 42 CFR 2.61 - Legal effect of order.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Legal effect of order. 2.61 Section 2.61 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.61 Legal...

  16. 42 CFR 2.61 - Legal effect of order.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Legal effect of order. 2.61 Section 2.61 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.61 Legal...

  17. 42 CFR 2.61 - Legal effect of order.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Legal effect of order. 2.61 Section 2.61 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.61 Legal...

  18. 36 CFR 261.52 - Fire.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Fire. 261.52 Section 261.52... in Areas Designated by Order § 261.52 Fire. When provided by an order, the following are prohibited: (a) Building, maintaining, attending or using a fire, campfire, or stove fire. (b) Using an explosive...

  19. 36 CFR 261.52 - Fire.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Fire. 261.52 Section 261.52... in Areas Designated by Order § 261.52 Fire. When provided by an order, the following are prohibited: (a) Building, maintaining, attending or using a fire, campfire, or stove fire. (b) Using an explosive...

  20. 36 CFR 261.52 - Fire.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Fire. 261.52 Section 261.52... in Areas Designated by Order § 261.52 Fire. When provided by an order, the following are prohibited: (a) Building, maintaining, attending or using a fire, campfire, or stove fire. (b) Using an explosive...

  1. 36 CFR 261.52 - Fire.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Fire. 261.52 Section 261.52... in Areas Designated by Order § 261.52 Fire. When provided by an order, the following are prohibited: (a) Building, maintaining, attending or using a fire, campfire, or stove fire. (b) Using an explosive...

  2. 40 CFR 98.261 - Reporting threshold.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Reporting threshold. 98.261 Section 98.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.261 Reporting threshold. You must report GHG emissions under this subpart if your...

  3. 40 CFR 98.261 - Reporting threshold.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Reporting threshold. 98.261 Section 98.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.261 Reporting threshold. You must report GHG emissions under this subpart if your...

  4. 40 CFR 98.261 - Reporting threshold.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Reporting threshold. 98.261 Section 98.261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.261 Reporting threshold. You must report GHG emissions under this subpart if your...

  5. 36 CFR 261.56 - Use of vehicles off National Forest System roads.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Forest System roads. 261.56 Section 261.56 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.56 Use of vehicles off... National Forest System roads. [42 FR 2957, Jan. 14, 1977, as amended at 66 FR 3218, Jan. 12, 2001] ...

  6. 12 CFR 261b.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Definitions. 261b.2 Section 261b.2 Banks and... REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.2 Definitions. For purposes of this part, the following... bank capital and surplus which may be represented by loans secured by stock and bond collateral under...

  7. 12 CFR 261b.3 - Conduct of agency business.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Conduct of agency business. 261b.3 Section 261b.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.3 Conduct of agency business. Members shall...

  8. 12 CFR 261b.13 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Fees. 261b.13 Section 261b.13 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.13 Fees. (a) Copies of transcripts, recordings or transcriptions of recordings...

  9. 12 CFR 261b.10 - Certification of General Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Certification of General Counsel. 261b.10 Section 261b.10 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.10 Certification of General Counsel...

  10. 12 CFR 261b.11 - Transcripts, recordings, and minutes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Transcripts, recordings, and minutes. 261b.11 Section 261b.11 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.11 Transcripts, recordings, and...

  11. 12 CFR 261b.6 - Public announcement of meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Public announcement of meetings. 261b.6 Section 261b.6 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.6 Public announcement of meetings. (a...

  12. 27 CFR 26.261 - Action by district director of customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Action by district director of customs. 26.261 Section 26.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX..., 1975] Editorial Note: For Federal Register citations affecting § 26.261, see the List of CFR Sections...

  13. 27 CFR 26.261 - Action by district director of customs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Action by district director of customs. 26.261 Section 26.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX..., 1975] Editorial Note: For Federal Register citations affecting § 26.261, see the List of CFR Sections...

  14. 27 CFR 26.261 - Action by district director of customs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Action by district director of customs. 26.261 Section 26.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX..., 1975] Editorial Note: For Federal Register citations affecting § 26.261, see the List of CFR Sections...

  15. 12 CFR 261b.3 - Conduct of agency business.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Conduct of agency business. 261b.3 Section 261b... SYSTEM (CONTINUED) RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.3 Conduct of agency business. Members shall not jointly conduct or dispose of official agency business other than in accordance with...

  16. 12 CFR 261b.13 - Fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Fees. 261b.13 Section 261b.13 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.13 Fees. (a) Copies of transcripts, recordings or transcriptions of recordings...

  17. 36 CFR 261.16 - Developed recreation sites.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Developed recreation sites. 261.16 Section 261.16 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.16 Developed recreation sites. The following are prohibited: (a) Occupying any portion of the site for other...

  18. 40 CFR 261.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Purpose and scope. 261.1 Section 261.1... AND LISTING OF HAZARDOUS WASTE General § 261.1 Purpose and scope. (a) This part identifies those solid... hazardous for purposes of the regulations implementing subtitle C of RCRA. For example, it does not apply to...

  19. 40 CFR 261.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Purpose and scope. 261.1 Section 261.1... AND LISTING OF HAZARDOUS WASTE General § 261.1 Purpose and scope. (a) This part identifies those solid... hazardous for purposes of the regulations implementing subtitle C of RCRA. For example, it does not apply to...

  20. 30 CFR 250.261 - What environmental impact analysis (EIA) information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Operations Coordination Documents (docd) § 250.261 What environmental impact analysis (EIA) information must... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental impact analysis (EIA) information must accompany the DPP or DOCD? 250.261 Section 250.261 Mineral Resources MINERALS MANAGEMENT...

  1. Implantation of GL261 neurospheres into C57/BL6 mice: a more reliable syngeneic graft model for research on glioma-initiating cells.

    PubMed

    Yi, Liang; Zhou, Chun; Wang, Bing; Chen, Tunan; Xu, Minhui; Xu, Lunshan; Feng, Hua

    2013-08-01

    Recent studies have demonstrated that inflammatory cells and inflammatory mediators are indispensable components of the tumor-initiating cell (TIC) niche and regulate the malignant behavior of TICs. However, conventional animal models for glioma-initiating cell (GIC) studies are based on the implantation of GICs from human glioblastoma (GBM) into immunodeficient mice without the regulation of immune system. Whether animal models can mimic the cellular microenvironment of malignancy and evaluate the biological features of GICs accurately is unclear. Here, we detected the biological features of neurosphere-like tumor cells derived from the murine GBM cell line GL261 (GL261-NS) and from primary human GBM (PGBM-NS) in vitro, injected GL261-NS into syngeneic C57/BL6 mouse brain and injected PGBM-NS into NOD/SCID mouse brain, respectively. The tumorigenic characteristics of the two different orthotopic transplantation models were analyzed and the histological discrepancy between grafts and human primary GBM was compared. We found that GICs enriched in GL261-NS, GL261-NS and PGBM-NS exhibited increased GIC potential and enhanced chemoresistance in vitro. GL261-NS was significantly more aggressive compared to GL261 adhesive cells (GL261-AC) in vivo and the enhanced aggression was more significant in syngeneic mice compared to immunodeficient mice. The discrepancy of tumorigenicity between GL261-NS and GL261-AC in C57/BL6 mice was also larger compared to that between PGBM-NS and PGBM-AC in immunodeficient mice. Syngrafts derived from GL261-NS in C57/BL6 mice corresponded to the human GBM histologically better, compared with xenografts derived from PGBM-NS in NOD/SCID mice, which lack inflammatory cells and inflammatory mediators. We conclude that the inflammatory niche is involved in the tumorigenicity of GICs and implantation of GL261-NS into C57/BL6 mice is a more reliable syngeneic graft model for in vivo study on GICs relative to the immunodeficiency model.

  2. 45 CFR 261.61 - How must a State document a work-eligible individual's hours of participation?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Participation Information? § 261.61 How must a State document a work-eligible individual's hours of... 45 Public Welfare 2 2011-10-01 2011-10-01 false How must a State document a work-eligible individual's hours of participation? 261.61 Section 261.61 Public Welfare Regulations Relating to Public...

  3. 42 CFR 2.61 - Legal effect of order.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Legal effect of order. 2.61 Section 2.61 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.61 Legal.... Such an order does not compel disclosure. A subpoena or a similar legal mandate must be issued in order...

  4. 42 CFR 2.61 - Legal effect of order.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Legal effect of order. 2.61 Section 2.61 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.61 Legal.... Such an order does not compel disclosure. A subpoena or a similar legal mandate must be issued in order...

  5. 12 CFR 261b.9 - Changes with respect to publicly announced meeting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Changes with respect to publicly announced meeting. 261b.9 Section 261b.9 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.9 Changes with...

  6. 12 CFR 261b.7 - Meetings closed to public observation under expedited procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Meetings closed to public observation under expedited procedures. 261b.7 Section 261b.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.7 Meetings...

  7. 12 CFR 261b.8 - Meetings closed to public observation under regular procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Meetings closed to public observation under regular procedures. 261b.8 Section 261b.8 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.8 Meetings...

  8. 12 CFR 261b.1 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Basis and scope. 261b.1 Section 261b.1 Banks... REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.1 Basis and scope. This part is issued by the Board of... public is entitled to the fullest practicable information regarding the decision making processes of the...

  9. 12 CFR 261b.5 - Exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Exemptions. 261b.5 Section 261b.5 Banks and... REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.5 Exemptions. (a) Except in a case where the agency finds that the public interest requires otherwise, the agency may close a meeting or a portion or portions of...

  10. 45 CFR 261.35 - Are there any special work provisions for single custodial parents?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... custodial parents? 261.35 Section 261.35 Public Welfare Regulations Relating to Public Welfare OFFICE OF...? § 261.35 Are there any special work provisions for single custodial parents? Yes. A single custodial parent or caretaker relative with a child under age six will count as engaged in work if he or she...

  11. 26 CFR 1.381(c)(26)-1 - Credit for employment of certain new employees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Credit for employment of certain new employees. 1.381(c)(26)-1 Section 1.381(c)(26)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(26)-1 Credit...

  12. 12 CFR 261b.3 - Conduct of agency business.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Conduct of agency business. 261b.3 Section 261b... SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.3 Conduct of agency business. Members shall not jointly conduct or dispose of official agency business other than in accordance with this part. ...

  13. 12 CFR 261b.12 - Procedures for inspection and obtaining copies of transcriptions and minutes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of transcriptions and minutes. 261b.12 Section 261b.12 Banks and Banking FEDERAL RESERVE SYSTEM... § 261b.12 Procedures for inspection and obtaining copies of transcriptions and minutes. (a) Any person may inspect or copy a transcript, a recording or transcription of a recording, or minutes described in...

  14. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... greater than 1 kg of acute hazardous waste listed in § 261.31 or § 261.33(e) in a calendar month, who does... greater than 1 kg of acute hazardous waste listed in § 261.31or § 261.33(e) in a calendar month, must... 262.42 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  15. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... greater than 1 kg of acute hazardous waste listed in § 261.31 or § 261.33(e) in a calendar month, who does... greater than 1 kg of acute hazardous waste listed in § 261.31or § 261.33(e) in a calendar month, must... 262.42 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  16. 30 CFR 550.261 - What environmental impact analysis (EIA) information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Operations Coordination Documents (docd) § 550.261 What environmental impact analysis (EIA) information must... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What environmental impact analysis (EIA) information must accompany the DPP or DOCD? 550.261 Section 550.261 Mineral Resources BUREAU OF OCEAN ENERGY...

  17. 30 CFR 550.261 - What environmental impact analysis (EIA) information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Operations Coordination Documents (docd) § 550.261 What environmental impact analysis (EIA) information must... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What environmental impact analysis (EIA) information must accompany the DPP or DOCD? 550.261 Section 550.261 Mineral Resources BUREAU OF OCEAN ENERGY...

  18. 30 CFR 550.261 - What environmental impact analysis (EIA) information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Operations Coordination Documents (docd) § 550.261 What environmental impact analysis (EIA) information must... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What environmental impact analysis (EIA) information must accompany the DPP or DOCD? 550.261 Section 550.261 Mineral Resources BUREAU OF OCEAN ENERGY...

  19. 43 CFR 30.261 - How does a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... tribe may purchase all or part of the available interests specified in the probate decision. A tribe may... option to purchase? 30.261 Section 30.261 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE HEARINGS PROCEDURES Tribal Purchase of Interests Under Special Statutes § 30.261 How does...

  20. 45 CFR 261.50 - What happens if a State fails to meet the participation rates?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What happens if a State fails to meet the participation rates? 261.50 Section 261.50 Public Welfare Regulations Relating to Public Welfare OFFICE OF... Requirements? § 261.50 What happens if a State fails to meet the participation rates? (a) If we determine that...

  1. 45 CFR 261.50 - What happens if a State fails to meet the participation rates?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true What happens if a State fails to meet the participation rates? 261.50 Section 261.50 Public Welfare Regulations Relating to Public Welfare OFFICE OF... Requirements? § 261.50 What happens if a State fails to meet the participation rates? (a) If we determine that...

  2. 7 CFR 868.261 - Grade and grade requirements for the classes of brown rice for processing. (See also § 868.263.)

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... rice for processing. (See also § 868.263.) 868.261 Section 868.261 Agriculture Regulations of the... COMMODITIES United States Standards for Brown Rice for Processing Principles Governing Application of Standards § 868.261 Grade and grade requirements for the classes of brown rice for processing. (See also...

  3. 7 CFR 868.261 - Grade and grade requirements for the classes of brown rice for processing. (See also § 868.263.)

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... rice for processing. (See also § 868.263.) 868.261 Section 868.261 Agriculture Regulations of the... COMMODITIES United States Standards for Brown Rice for Processing Principles Governing Application of Standards § 868.261 Grade and grade requirements for the classes of brown rice for processing. (See also...

  4. 7 CFR 868.261 - Grade and grade requirements for the classes of brown rice for processing. (See also § 868.263.)

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... rice for processing. (See also § 868.263.) 868.261 Section 868.261 Agriculture Regulations of the... COMMODITIES United States Standards for Brown Rice for Processing Principles Governing Application of Standards § 868.261 Grade and grade requirements for the classes of brown rice for processing. (See also...

  5. 7 CFR 868.261 - Grade and grade requirements for the classes of brown rice for processing. (See also § 868.263.)

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... rice for processing. (See also § 868.263.) 868.261 Section 868.261 Agriculture Regulations of the... COMMODITIES United States Standards for Brown Rice for Processing Principles Governing Application of Standards § 868.261 Grade and grade requirements for the classes of brown rice for processing. (See also...

  6. 7 CFR 868.261 - Grade and grade requirements for the classes of brown rice for processing. (See also § 868.263.)

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... rice for processing. (See also § 868.263.) 868.261 Section 868.261 Agriculture Regulations of the... COMMODITIES United States Standards for Brown Rice for Processing Principles Governing Application of Standards § 868.261 Grade and grade requirements for the classes of brown rice for processing. (See also...

  7. 45 CFR 261.34 - Are there any limitations in counting job search and job readiness assistance toward the...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Are there any limitations in counting job search and job readiness assistance toward the participation rates? 261.34 Section 261.34 Public Welfare... Work Activities and How Do They Count? § 261.34 Are there any limitations in counting job search and...

  8. 45 CFR 261.34 - Are there any limitations in counting job search and job readiness assistance toward the...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Are there any limitations in counting job search and job readiness assistance toward the participation rates? 261.34 Section 261.34 Public Welfare... Work Activities and How Do They Count? § 261.34 Are there any limitations in counting job search and...

  9. 45 CFR 261.34 - Are there any limitations in counting job search and job readiness assistance toward the...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Are there any limitations in counting job search and job readiness assistance toward the participation rates? 261.34 Section 261.34 Public Welfare... Work Activities and How Do They Count? § 261.34 Are there any limitations in counting job search and...

  10. 45 CFR 261.34 - Are there any limitations in counting job search and job readiness assistance toward the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Are there any limitations in counting job search and job readiness assistance toward the participation rates? 261.34 Section 261.34 Public Welfare... Work Activities and How Do They Count? § 261.34 Are there any limitations in counting job search and...

  11. 45 CFR 261.34 - Are there any limitations in counting job search and job readiness assistance toward the...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Are there any limitations in counting job search and job readiness assistance toward the participation rates? 261.34 Section 261.34 Public Welfare... Work Activities and How Do They Count? § 261.34 Are there any limitations in counting job search and...

  12. 12 CFR 261b.4 - Meetings open to public observation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Meetings open to public observation. 261b.4... RESERVE SYSTEM (CONTINUED) RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.4 Meetings open to public observation. (a) Except as provided in § 261b.5, every portion of every meeting of the agency shall be open to...

  13. 12 CFR 261b.4 - Meetings open to public observation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Meetings open to public observation. 261b.4... RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.4 Meetings open to public observation. (a) Except as provided in § 261b.5, every portion of every meeting of the agency shall be open to...

  14. 12 CFR 261b.4 - Meetings open to public observation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Meetings open to public observation. 261b.4... RESERVE SYSTEM (CONTINUED) RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.4 Meetings open to public observation. (a) Except as provided in § 261b.5, every portion of every meeting of the agency shall be open to...

  15. 12 CFR 261b.4 - Meetings open to public observation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Meetings open to public observation. 261b.4... RESERVE SYSTEM (CONTINUED) RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.4 Meetings open to public observation. (a) Except as provided in § 261b.5, every portion of every meeting of the agency shall be open to...

  16. 12 CFR 261b.4 - Meetings open to public observation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Meetings open to public observation. 261b.4... RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.4 Meetings open to public observation. (a) Except as provided in § 261b.5, every portion of every meeting of the agency shall be open to...

  17. 49 CFR 40.261 - What is a refusal to take an alcohol test, and what are the consequences?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... what are the consequences? 40.261 Section 40.261 Transportation Office of the Secretary of... Testing § 40.261 What is a refusal to take an alcohol test, and what are the consequences? (a) As an... incur the same consequences specified under DOT agency regulations for a violation of those DOT agency...

  18. 36 CFR 261.14 - Use by over-snow vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Use by over-snow vehicles. 261.14 Section 261.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.14 Use by over-snow vehicles. It is prohibited to possess or operate an over-snow vehicle on National Forest...

  19. 33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from St. Marys River to Key Largo. 117.261 Section 117.261 Navigation and Navigable Waters COAST GUARD....261 Atlantic Intracoastal Waterway from St. Marys River to Key Largo. (a) General. Public vessels of..., mile 777.9 at St. Augustine. The draw shall open on signal; except that, from 7 a.m. to 6 p.m. the draw...

  20. 45 CFR 261.57 - What happens if a State sanctions a single parent of a child under six who cannot get needed...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Penalties Apply to States Related to Work Requirements? § 261.57 What happens if a State sanctions a single parent... of a child under six who cannot get needed child care? 261.57 Section 261.57 Public Welfare...

  1. Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma.

    PubMed

    Pellegatta, Serena; Valletta, Lorella; Corbetta, Cristina; Patanè, Monica; Zucca, Ileana; Riccardi Sirtori, Federico; Bruzzone, Maria Grazia; Fogliatto, Gianpaolo; Isacchi, Antonella; Pollo, Bianca; Finocchiaro, Gaetano

    2015-01-21

    The R132H mutation of cytosolic isocitrate dehydrogenase (IDH1) is present in the majority of low grade gliomas.Immunotherapy in these tumors has an interesting, still unexploited, therapeutic potential, as they are less immunosuppressive than glioblastomas. Using site-directed mutagenesis we introduced the R132H mutation into the murine glioma cell line GL261,creating mIDH1-GL261. Presence of the mutation was confirmed by immunoblotting and production of the oncometabolite 2-hydroxyglutarate (2HG), demonstrated by mass spectrometry (LC-MS/MS) performed on cell supernatant. In vitro mIDH1-GL261 had different morphology but similar growth rate than parental GL261 (p-GL261). After intracranial injection, MRI suggested that the initial growth rate was slower in mIDH1-GL261 than p-GL261 gliomas but overall survival was similar. mIDH1-GL261 gliomas showed evidence of R132H expression and of intratumoral 2HG production (evaluated by MRS and LC-MS/MS). Immunizations were performed nine days after intracranial implantation of mIDH1- or p-GL261 cells by three subcutaneous injections of five different peptides encompassing the IDH1 mutation site, all emulsified with Montanide ISA-51, in association with GM-CSF. Control mice were injected with four ovalbumin peptides or vehicle. Mice with mIDH1-GL261 but not p-GL261 gliomas treated with mIDH1 peptides survived longer than controls; 25% of them were cured. Immunized mice showed higher amounts of peripheral CD8+ T cells, higher production of IFN-γ, and evidence of anti-mIDH1 antibodies.Immunizations led to intratumoral up-regulation of IFN-γ, granzyme-b and perforin-1 and down-regulation of TGF-β2 and IL-10. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations.

  2. 24 CFR 983.261 - When occupancy may exceed 25 percent cap on the number of PBV units in each building.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... percent cap on the number of PBV units in each building. 983.261 Section 983.261 Housing and Urban...) PROGRAM Occupancy § 983.261 When occupancy may exceed 25 percent cap on the number of PBV units in each... contract for contract units in excess of the 25 percent cap pursuant to § 983.56(a). (b) In referring...

  3. 40 CFR 261.140 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Applicability. 261.140 Section 261.140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Financial Requirements for Management of Excluded Hazardous Secondary...

  4. 40 CFR 261.23 - Characteristic of reactivity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 261.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Characteristics of Hazardous Waste § 261.23 Characteristic of reactivity. (a) A solid waste exhibits the characteristic of reactivity if a representative...

  5. 40 CFR 261.23 - Characteristic of reactivity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 261.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Characteristics of Hazardous Waste § 261.23 Characteristic of reactivity. (a) A solid waste exhibits the characteristic of reactivity if a representative...

  6. 40 CFR 261.23 - Characteristic of reactivity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 261.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Characteristics of Hazardous Waste § 261.23 Characteristic of reactivity. (a) A solid waste exhibits the characteristic of reactivity if a representative...

  7. 40 CFR 261.23 - Characteristic of reactivity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 261.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Characteristics of Hazardous Waste § 261.23 Characteristic of reactivity. (a) A solid waste exhibits the characteristic of reactivity if a representative...

  8. 40 CFR 261.23 - Characteristic of reactivity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 261.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Characteristics of Hazardous Waste § 261.23 Characteristic of reactivity. (a) A solid waste exhibits the characteristic of reactivity if a representative...

  9. 40 CFR Appendix III to Part 261 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false [Reserved] III Appendix III to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Appendix III to Part 261 [Reserved] ...

  10. 40 CFR Appendix II to Part 261 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false [Reserved] II Appendix II to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Appendix II to Part 261 [Reserved] ...

  11. 37 CFR 261.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Definitions. 261.2 Section 261.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION..., that makes eligible non-subscription transmissions of digital audio programming over the Internet...

  12. 37 CFR 261.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Definitions. 261.2 Section 261.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION..., that makes eligible non-subscription transmissions of digital audio programming over the Internet...

  13. 37 CFR 261.5 - Confidential information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 261... TRANSMISSIONS AND THE MAKING OF EPHEMERAL REPRODUCTIONS § 261.5 Confidential information. (a) For purposes of this part, “Confidential Information” shall include the statements of account, any information...

  14. 12 CFR 261.20 - Confidential supervisory information made available to supervised financial institutions and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... available to supervised financial institutions and financial institution supervisory agencies. 261.20... Supervised Institutions, Financial Institution Supervisory Agencies, Law Enforcement Agencies, and Others in Certain Circumstances § 261.20 Confidential supervisory information made available to supervised financial...

  15. 37 CFR 261.1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false General. 261.1 Section 261.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... for the public performance of sound recordings in certain digital transmissions by certain Licensees...

  16. 37 CFR 261.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false General. 261.1 Section 261.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... for the public performance of sound recordings in certain digital transmissions by certain Licensees...

  17. 37 CFR 261.1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false General. 261.1 Section 261.1 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION... royalty payments for the public performance of sound recordings in certain digital transmissions by...

  18. 37 CFR 261.1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false General. 261.1 Section 261.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... for the public performance of sound recordings in certain digital transmissions by certain Licensees...

  19. 37 CFR 261.1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false General. 261.1 Section 261.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... for the public performance of sound recordings in certain digital transmissions by certain Licensees...

  20. 40 CFR 261.30 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Corrosive Waste (C) Reactive Waste (R) Toxicity Characteristic Waste (E) Acute Hazardous Waste (H) Toxic... Toxicity Characteristic Waste (E) or Toxic Waste (T) in §§ 261.31 and 261.32. (c) Each hazardous waste... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION...

  1. 40 CFR 261.30 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Corrosive Waste (C) Reactive Waste (R) Toxicity Characteristic Waste (E) Acute Hazardous Waste (H) Toxic... Toxicity Characteristic Waste (E) or Toxic Waste (T) in §§ 261.31 and 261.32. (c) Each hazardous waste... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION...

  2. 40 CFR 261.30 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Corrosive Waste (C) Reactive Waste (R) Toxicity Characteristic Waste (E) Acute Hazardous Waste (H) Toxic... Toxicity Characteristic Waste (E) or Toxic Waste (T) in §§ 261.31 and 261.32. (c) Each hazardous waste... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION...

  3. 40 CFR 261.30 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Corrosive Waste (C) Reactive Waste (R) Toxicity Characteristic Waste (E) Acute Hazardous Waste (H) Toxic... Toxicity Characteristic Waste (E) or Toxic Waste (T) in §§ 261.31 and 261.32. (c) Each hazardous waste... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION...

  4. 40 CFR 261.30 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Corrosive Waste (C) Reactive Waste (R) Toxicity Characteristic Waste (E) Acute Hazardous Waste (H) Toxic... Toxicity Characteristic Waste (E) or Toxic Waste (T) in §§ 261.31 and 261.32. (c) Each hazardous waste... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION...

  5. 40 CFR Appendix V to Part 261 - Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Reserved V Appendix V to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION... Materials Wording of the instruments. Appendix V to Part 261 [Reserved for Infectious Waste Treatment...

  6. 40 CFR Appendix V to Part 261 - Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Reserved V Appendix V to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION... Materials Wording of the instruments. Appendix V to Part 261 [Reserved for Infectious Waste Treatment...

  7. 37 CFR 261.5 - Confidential information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 261... THE MAKING OF EPHEMERAL REPRODUCTIONS § 261.5 Confidential information. (a) For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including...

  8. 30 CFR 1206.261 - Transportation allowances-general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Transportation allowances-general. 1206.261... INTERIOR Natural Resources Revenue PRODUCT VALUATION Federal Coal § 1206.261 Transportation allowances... transportation costs shall not be included in the transportation allowance. (b) Under no circumstances will the...

  9. 49 CFR 234.261 - Highway traffic signal pre-emption.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Highway traffic signal pre-emption. 234.261..., AND EMERGENCY NOTIFICATION SYSTEMS Maintenance, Inspection, and Testing Inspections and Tests § 234.261 Highway traffic signal pre-emption. Highway traffic signal pre-emption interconnections, for which...

  10. 49 CFR 234.261 - Highway traffic signal pre-emption.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Highway traffic signal pre-emption. 234.261..., AND EMERGENCY NOTIFICATION SYSTEMS Maintenance, Inspection, and Testing Inspections and Tests § 234.261 Highway traffic signal pre-emption. Highway traffic signal pre-emption interconnections, for which...

  11. 49 CFR 234.261 - Highway traffic signal pre-emption.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Highway traffic signal pre-emption. 234.261..., AND EMERGENCY NOTIFICATION SYSTEMS Maintenance, Inspection, and Testing Inspections and Tests § 234.261 Highway traffic signal pre-emption. Highway traffic signal pre-emption interconnections, for which...

  12. 40 CFR Appendix V to Part 261 - Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Reserved V Appendix V to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION... Materials Wording of the instruments. Appendix V to Part 261 [Reserved for Infectious Waste Treatment...

  13. 40 CFR Appendix V to Part 261 - Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Reserved V Appendix V to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION... Materials Wording of the instruments. Appendix V to Part 261 [Reserved for Infectious Waste Treatment...

  14. 40 CFR Appendix V to Part 261 - Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Reserved V Appendix V to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION... Materials Wording of the instruments. Appendix V to Part 261 [Reserved for Infectious Waste Treatment...

  15. 30 CFR 206.261 - Transportation allowances-general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Transportation allowances-general. 206.261... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.261 Transportation allowances—general. (a) For ad valorem... mine and, if applicable, from the wash plant to a remote sales point. In-mine transportation costs...

  16. 36 CFR 261.13 - Motor vehicle use.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Forest Service; (e) Use of any fire, military, emergency, or law enforcement vehicle for emergency... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Motor vehicle use. 261.13 Section 261.13 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS...

  17. 30 CFR 1206.261 - Transportation allowances-general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Transportation allowances-general. 1206.261... RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.261 Transportation allowances—general. (a) For ad... mine and, if applicable, from the wash plant to a remote sales point. In-mine transportation costs...

  18. 30 CFR 1206.261 - Transportation allowances-general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Transportation allowances-general. 1206.261... RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.261 Transportation allowances—general. (a) For ad... mine and, if applicable, from the wash plant to a remote sales point. In-mine transportation costs...

  19. 30 CFR 1206.261 - Transportation allowances-general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Transportation allowances-general. 1206.261... RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.261 Transportation allowances—general. (a) For ad... mine and, if applicable, from the wash plant to a remote sales point. In-mine transportation costs...

  20. 49 CFR 234.261 - Highway traffic signal pre-emption.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Maintenance, Inspection, and Testing Inspections and Tests § 234.261 Highway traffic signal pre-emption. Highway traffic signal pre-emption interconnections, for which a railroad has maintenance responsibility... 49 Transportation 4 2010-10-01 2010-10-01 false Highway traffic signal pre-emption. 234.261...

  1. 49 CFR 234.261 - Highway traffic signal pre-emption.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Maintenance, Inspection, and Testing Inspections and Tests § 234.261 Highway traffic signal pre-emption. Highway traffic signal pre-emption interconnections, for which a railroad has maintenance responsibility... 49 Transportation 4 2011-10-01 2011-10-01 false Highway traffic signal pre-emption. 234.261...

  2. 27 CFR 41.261 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Records. 41.261 Section 41... TOBACCO Importation of Processed Tobacco Operations of Importers of Processed Tobacco § 41.261 Records. (a... records of operations and transactions. A person purchasing processed tobacco from the importer in a...

  3. 36 CFR 261.19 - Boundary Waters Canoe Area Wilderness.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Boundary Waters Canoe Area Wilderness. 261.19 Section 261.19 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... or other mechanical device capable of propelling a watercraft through water by any means, except by...

  4. 36 CFR 261.19 - Boundary Waters Canoe Area Wilderness.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Boundary Waters Canoe Area Wilderness. 261.19 Section 261.19 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... or other mechanical device capable of propelling a watercraft through water by any means, except by...

  5. 12 CFR 261.11 - Records available for public inspection and copying.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Governors of the Federal Reserve System, 20th Street and Constitution Avenue, N.W., Washington, D.C. 20551... copying. 261.11 Section 261.11 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) RULES REGARDING AVAILABILITY OF INFORMATION Published...

  6. 36 CFR 261.16 - Developed recreation sites.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Developed recreation sites. 261.16 Section 261.16 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE..., or using a fire outside of a fire ring provided by the Forest Service for such purpose or outside of...

  7. 36 CFR 261.14 - Use by over-snow vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section: (a) Limited administrative use by the Forest Service; (b) Use of any fire, military, emergency... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Use by over-snow vehicles. 261.14 Section 261.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE...

  8. 27 CFR 20.261 - Records of completely denatured alcohol.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Records of completely denatured alcohol. 20.261 Section 20.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM...

  9. 27 CFR 20.261 - Records of completely denatured alcohol.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Records of completely denatured alcohol. 20.261 Section 20.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM...

  10. 27 CFR 28.261 - Notice to district director of customs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Notice to district director of customs. 28.261 Section 28.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Proceedings at Ports of...

  11. 27 CFR 28.261 - Notice to district director of customs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Notice to district director of customs. 28.261 Section 28.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL EXPORTATION OF ALCOHOL Proceedings at Ports of...

  12. 27 CFR 28.261 - Notice to district director of customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Notice to district director of customs. 28.261 Section 28.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Proceedings at Ports of...

  13. 27 CFR 28.261 - Notice to district director of customs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Notice to district director of customs. 28.261 Section 28.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL EXPORTATION OF ALCOHOL Proceedings at Ports of...

  14. 27 CFR 28.261 - Notice to district director of customs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Notice to district director of customs. 28.261 Section 28.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Proceedings at Ports of...

  15. 40 CFR 261.148 - Incapacity of owners or operators, guarantors, or financial institutions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., guarantors, or financial institutions. 261.148 Section 261.148 Protection of Environment ENVIRONMENTAL... owners or operators, guarantors, or financial institutions. (a) An owner or operator must notify the... financial assurance or liability coverage in the event of bankruptcy of the trustee or issuing institution...

  16. 45 CFR 261.14 - What is the penalty if an individual refuses to engage in work?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... engage in work? 261.14 Section 261.14 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual...

  17. 36 CFR 261.5 - Fire.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... that is not a prescribed fire that damages the National Forest System. (f) Building, attending... prevent its escape. (g) Negligently failing to maintain control of a prescribed fire on Non-National... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Fire. 261.5 Section 261.5...

  18. 36 CFR 261.5 - Fire.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... that is not a prescribed fire that damages the National Forest System. (f) Building, attending... prevent its escape. (g) Negligently failing to maintain control of a prescribed fire on Non-National... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Fire. 261.5 Section 261.5...

  19. 36 CFR 261.5 - Fire.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... that is not a prescribed fire that damages the National Forest System. (f) Building, attending... prevent its escape. (g) Negligently failing to maintain control of a prescribed fire on Non-National... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Fire. 261.5 Section 261.5...

  20. 36 CFR 261.5 - Fire.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... that is not a prescribed fire that damages the National Forest System. (f) Building, attending... prevent its escape. (g) Negligently failing to maintain control of a prescribed fire on Non-National... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Fire. 261.5 Section 261.5...

  1. 36 CFR 261.5 - Fire.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... that is not a prescribed fire that damages the National Forest System. (f) Building, attending... prevent its escape. (g) Negligently failing to maintain control of a prescribed fire on Non-National... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Fire. 261.5 Section 261.5...

  2. 37 CFR 261.8 - Unclaimed funds.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Unclaimed funds. 261.8... THE MAKING OF EPHEMERAL REPRODUCTIONS § 261.8 Unclaimed funds. If a Designated Agent is unable to... expiration of the three (3) year period. After the expiration of this period, the unclaimed funds of the...

  3. 36 CFR 261.13 - Motor vehicle use.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Motor vehicle use. 261.13... General Prohibitions § 261.13 Motor vehicle use. After National Forest System roads, National Forest... have been identified on a motor vehicle use map, it is prohibited to possess or operate a motor vehicle...

  4. 36 CFR 261.13 - Motor vehicle use.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Motor vehicle use. 261.13... General Prohibitions § 261.13 Motor vehicle use. After National Forest System roads, National Forest... have been identified on a motor vehicle use map, it is prohibited to possess or operate a motor vehicle...

  5. 36 CFR 261.13 - Motor vehicle use.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Motor vehicle use. 261.13... General Prohibitions § 261.13 Motor vehicle use. After National Forest System roads, National Forest... have been identified on a motor vehicle use map, it is prohibited to possess or operate a motor vehicle...

  6. 20 CFR 416.261 - What are special SSI cash benefits and when are they payable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What are special SSI cash benefits and when are they payable. 416.261 Section 416.261 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who...

  7. 12 CFR 261a.10 - Appeal of adverse determination of request for access or amendment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of Governors of the Federal Reserve System, 20th Street and Constitution Avenue, NW., Washington, DC... access or amendment. 261a.10 Section 261a.10 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) RULES REGARDING ACCESS TO PERSONAL INFORMATION...

  8. 36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

  9. 36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

  10. 36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

  11. 36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

  12. 41 CFR 301-10.261 - When may I use a Government aircraft for travel?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... or lost work time while in travel status and certain other costs should be considered when comparing... Government aircraft for travel? 301-10.261 Section 301-10.261 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10...

  13. 41 CFR 301-10.261 - When may I use a Government aircraft for travel?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... or lost work time while in travel status and certain other costs should be considered when comparing... Government aircraft for travel? 301-10.261 Section 301-10.261 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10...

  14. 41 CFR 301-10.261 - When may I use a Government aircraft for travel?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... or lost work time while in travel status and certain other costs should be considered when comparing... Government aircraft for travel? 301-10.261 Section 301-10.261 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10...

  15. 41 CFR 301-10.261 - When may I use a Government aircraft for travel?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or lost work time while in travel status and certain other costs should be considered when comparing... Government aircraft for travel? 301-10.261 Section 301-10.261 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10...

  16. 41 CFR 301-10.261 - When may I use a Government aircraft for travel?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... or lost work time while in travel status and certain other costs should be considered when comparing... Government aircraft for travel? 301-10.261 Section 301-10.261 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10...

  17. 27 CFR 26.261 - Action by district director of customs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Action by district director of customs. 26.261 Section 26.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LIQUORS AND ARTICLES FROM PUERTO RICO AND THE...

  18. 27 CFR 26.261 - Action by district director of customs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Action by district director of customs. 26.261 Section 26.261 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LIQUORS AND ARTICLES FROM PUERTO RICO AND THE...

  19. 40 CFR 180.261 - N-(Mercaptomethyl) phthali-mide S-(O,O-dimethyl phosphoro-dithioate) and its oxygen analog...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-dimethyl phosphoro-dithioate) and its oxygen analog; tolerances for residues. 180.261 Section 180.261...-mide S-(O,O-dimethyl phosphoro-dithioate) and its oxygen analog; tolerances for residues. (a) General...-(O,O-dimethyl phosphorodithioate) and its oxygen analog N-(mercaptomethyl) phthalimide S-(O,O...

  20. 37 CFR 261.4 - Terms for making payment of royalty fees and statements of account.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... royalty fees and statements of account. 261.4 Section 261.4 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES RATES AND TERMS FOR... payment of royalty fees and statements of account. (a) A Licensee shall make the royalty payments due...

  1. 12 CFR 261a.11 - Restrictions on disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Restrictions on disclosure. 261a.11 Section 261a.11 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE... in a designated system of records shall be disclosed to any person or agency without the prior...

  2. 45 CFR 261.20 - How will we hold a State accountable for achieving the work objectives of TANF?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the work objectives of TANF? 261.20 Section 261.20 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing...

  3. 34 CFR 75.261 - Extension of a project period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Extension of a project period. 75.261 Section 75.261 Education Office of the Secretary, Department of Education DIRECT GRANT PROGRAMS How Grants Are Made..., subpart C. (3) The Rehabilitation Engineering Research Centers authorized under 29 U.S.C. 762(b)(3) and...

  4. 45 CFR 261.53 - May a State correct the problem before incurring a penalty?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false May a State correct the problem before incurring a penalty? 261.53 Section 261.53 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN...

  5. 36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

  6. 45 CFR 261.62 - What must a State do to verify the accuracy of its work participation information?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ensure a consistent measurement of the work participation rates, including the quality assurance... work participation information? 261.62 Section 261.62 Public Welfare Regulations Relating to Public..., DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK How Do We Ensure the Accuracy of Work...

  7. 45 CFR 261.62 - What must a State do to verify the accuracy of its work participation information?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ensure a consistent measurement of the work participation rates, including the quality assurance... work participation information? 261.62 Section 261.62 Public Welfare Regulations Relating to Public..., DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK How Do We Ensure the Accuracy of Work...

  8. 45 CFR 261.62 - What must a State do to verify the accuracy of its work participation information?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ensure a consistent measurement of the work participation rates, including the quality assurance... work participation information? 261.62 Section 261.62 Public Welfare Regulations Relating to Public..., DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK How Do We Ensure the Accuracy of Work...

  9. 45 CFR 261.62 - What must a State do to verify the accuracy of its work participation information?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ensure a consistent measurement of the work participation rates, including the quality assurance... work participation information? 261.62 Section 261.62 Public Welfare Regulations Relating to Public..., DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK How Do We Ensure the Accuracy of Work...

  10. 12 CFR 261a.7 - Special procedures for medical records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Special procedures for medical records. 261a.7... Requests by Individual to Whom Record Pertains § 261a.7 Special procedures for medical records. Medical or... physician, have an adverse effect upon the requester. Upon such determination, the information shall be...

  11. 49 CFR 26.1 - What are the objectives of this part?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What are the objectives of this part? 26.1 Section 26.1 Transportation Office of the Secretary of Transportation PARTICIPATION BY DISADVANTAGED BUSINESS... objectives of this part? This part seeks to achieve several objectives: (a) To ensure nondiscrimination in...

  12. 20 CFR 416.261 - What are special SSI cash benefits and when are they payable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What are special SSI cash benefits and when are they payable. 416.261 Section 416.261 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who...

  13. 20 CFR 416.261 - What are special SSI cash benefits and when are they payable.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What are special SSI cash benefits and when are they payable. 416.261 Section 416.261 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who...

  14. 20 CFR 416.261 - What are special SSI cash benefits and when are they payable.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What are special SSI cash benefits and when are they payable. 416.261 Section 416.261 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who...

  15. VizieR Online Data Catalog: Collinder 261 Chandra sources & optical counterparts (Vats+, 2017)

    NASA Astrophysics Data System (ADS)

    Vats, S.; van den Berg, M.

    2017-10-01

    Cr 261 was observed with the Advanced CCD Imaging Spectrometer (ACIS) on board Chandra starting 2009 November 9 14:50 UTC, for a total exposure time of 53.8ks (ObsID 11308). We retrieved optical images of Cr 261 in the B and V bands from the ESO public archive. These data were taken as part of the ESO Imaging Survey (EIS; program ID 164.O-0561). The observations of Cr 261 were made using the Wide Field Imager (WFI), mounted on the 2.2m MPG/ESO telescope at La Silla, Chile. The Cr 261 data were taken from 2001 June 27 23:55 UTC to 2001 June 28 00:38 UTC, with a total exposure time of 510s in the B and V filter each. (2 data files).

  16. 78 FR 70489 - Airworthiness Directives; Rolls-Royce plc Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... Airworthiness Directives; Rolls-Royce plc Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT..., and 560A2-61 turbofan engines. This AD requires replacement or repair of the low-pressure (LP...-61, 556B2-61, 560-61, and 560A2-61 turbofan engines. (d) Reason This AD was prompted by reports of...

  17. 45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... participate for the family to count in the numerator of the two-parent rate? 261.32 Section 261.32 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK...

  18. 45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... participate for the family to count in the numerator of the two-parent rate? 261.32 Section 261.32 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK...

  19. 45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... participate for the family to count in the numerator of the two-parent rate? 261.32 Section 261.32 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK...

  20. 36 CFR 261.56 - Use of vehicles off National Forest System roads.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Forest System roads. 261.56 Section 261.56 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT... National Forest System roads. When provided by an order, it is prohibited to possess or use a vehicle off National Forest System roads. [42 FR 2957, Jan. 14, 1977, as amended at 66 FR 3218, Jan. 12, 2001] ...

  1. 12 CFR 261b.12 - Procedures for inspection and obtaining copies of transcriptions and minutes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Procedures for inspection and obtaining copies of transcriptions and minutes. 261b.12 Section 261b.12 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS...

  2. 45 CFR 261.23 - What two-parent work rate must a State meet?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What two-parent work rate must a State meet? 261.23 Section 261.23 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE...-parent work rate must a State meet? Each State must achieve a 90 percent minimum two-parent participation...

  3. 40 CFR 261.40 - Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling. 261.40 Section 261.40 Protection of Environment...) Exported for Recycling. Used, intact CRTs exported for recycling are not solid wastes if they meet the...

  4. 40 CFR 261.40 - Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling. 261.40 Section 261.40 Protection of Environment...) Exported for Recycling. Used, intact CRTs exported for recycling are not solid wastes if they meet the...

  5. 40 CFR 261.40 - Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling. 261.40 Section 261.40 Protection of Environment...) Exported for Recycling. Used, intact CRTs exported for recycling are not solid wastes if they meet the...

  6. 40 CFR 261.40 - Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling. 261.40 Section 261.40 Protection of Environment...) Exported for Recycling. Used, intact CRTs exported for recycling are not solid wastes if they meet the...

  7. 40 CFR 261.40 - Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Conditional Exclusion for Used, Intact Cathode Ray Tubes (CRTs) Exported for Recycling. 261.40 Section 261.40 Protection of Environment...) Exported for Recycling. Used, intact CRTs exported for recycling are not solid wastes if they meet the...

  8. 30 CFR 250.261 - What environmental impact analysis (EIA) information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... analysis (EIA) information must accompany the DPP or DOCD? The following EIA information must accompany... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What environmental impact analysis (EIA) information must accompany the DPP or DOCD? 250.261 Section 250.261 Mineral Resources BUREAU OF OCEAN ENERGY...

  9. 43 CFR 30.261 - How does a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false How does a tribe exercise its statutory option to purchase? 30.261 Section 30.261 Public Lands: Interior Office of the Secretary of the Interior... a tribe exercise its statutory option to purchase? (a) To exercise its option to purchase, the tribe...

  10. 43 CFR 30.261 - How does a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true How does a tribe exercise its statutory option to purchase? 30.261 Section 30.261 Public Lands: Interior Office of the Secretary of the Interior... a tribe exercise its statutory option to purchase? (a) To exercise its option to purchase, the tribe...

  11. 43 CFR 30.261 - How does a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false How does a tribe exercise its statutory option to purchase? 30.261 Section 30.261 Public Lands: Interior Office of the Secretary of the Interior... a tribe exercise its statutory option to purchase? (a) To exercise its option to purchase, the tribe...

  12. 45 CFR 261.31 - How many hours must a work-eligible individual participate for the family to count in the...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... participate for the family to count in the numerator of the overall rate? 261.31 Section 261.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the...

  13. 45 CFR 261.31 - How many hours must a work-eligible individual participate for the family to count in the...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... participate for the family to count in the numerator of the overall rate? 261.31 Section 261.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the...

  14. 45 CFR 261.31 - How many hours must a work-eligible individual participate for the family to count in the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... participate for the family to count in the numerator of the overall rate? 261.31 Section 261.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the...

  15. 40 CFR 261.39 - Conditional Exclusion for Used, Broken Cathode Ray Tubes (CRTs) and Processed CRT Glass...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Cathode Ray Tubes (CRTs) and Processed CRT Glass Undergoing Recycling. 261.39 Section 261.39 Protection of... (CRTs) and Processed CRT Glass Undergoing Recycling. Used, broken CRTs are not solid wastes if they meet... destined for recycling and if they meet the following requirements: (1) Storage. The broken CRTs must be...

  16. 40 CFR 261.39 - Conditional Exclusion for Used, Broken Cathode Ray Tubes (CRTs) and Processed CRT Glass...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Cathode Ray Tubes (CRTs) and Processed CRT Glass Undergoing Recycling. 261.39 Section 261.39 Protection of... (CRTs) and Processed CRT Glass Undergoing Recycling. Used, broken CRTs are not solid wastes if they meet... destined for recycling and if they meet the following requirements: (1) Storage. The broken CRTs must be...

  17. 40 CFR 261.39 - Conditional Exclusion for Used, Broken Cathode Ray Tubes (CRTs) and Processed CRT Glass...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Cathode Ray Tubes (CRTs) and Processed CRT Glass Undergoing Recycling. 261.39 Section 261.39 Protection of... (CRTs) and Processed CRT Glass Undergoing Recycling. Used, broken CRTs are not solid wastes if they meet... destined for recycling and if they meet the following requirements: (1) Storage. The broken CRTs must be...

  18. 40 CFR 261.39 - Conditional Exclusion for Used, Broken Cathode Ray Tubes (CRTs) and Processed CRT Glass...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Cathode Ray Tubes (CRTs) and Processed CRT Glass Undergoing Recycling. 261.39 Section 261.39 Protection of... (CRTs) and Processed CRT Glass Undergoing Recycling. Used, broken CRTs are not solid wastes if they meet... destined for recycling and if they meet the following requirements: (1) Storage. The broken CRTs must be...

  19. 40 CFR 261.39 - Conditional Exclusion for Used, Broken Cathode Ray Tubes (CRTs) and Processed CRT Glass...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Cathode Ray Tubes (CRTs) and Processed CRT Glass Undergoing Recycling. 261.39 Section 261.39 Protection of... (CRTs) and Processed CRT Glass Undergoing Recycling. Used, broken CRTs are not solid wastes if they meet... destined for recycling and if they meet the following requirements: (1) Storage. The broken CRTs must be...

  20. Presenting evidence to patients online: what do web users think of consumer summaries of cochrane musculoskeletal reviews?

    PubMed

    Brehaut, Jamie C; Santesso, Nancy; O'Connor, Annette M; Lott, Alison; Lindgaard, Gitte; Syrowatka, Ania; Graham, Ian D; Tugwell, Peter S

    2011-01-18

    The Internet has the potential to be an effective medium for delivering health care knowledge to consumers. While computer usability research makes recommendations about how to present Web-based information generally, there remains no clear guidance on how to present specific forms of health care research evidence online in a way that facilitates understanding and good health care decision making. The two goals of this study were to describe the Cochrane Musculoskeletal Group's (CMSG's) process for developing online patient-focused summaries of systematic reviews and to evaluate the impressions of these summaries formed by users. A process for summarizing the results of systematic reviews via consumer summaries has evolved over 15 years. An evaluation of this approach took the form of Internet surveys on the Arthritis Society of Canada website and surveys of members of the Canadian Arthritis Patient Alliance (CAPA). Respondents provided information on background, relationship to the decision, their satisfaction with and preparation for decision making, and suggestions for improvements to the summaries. Survey data were collected between August 1, 2005, and February 28, 2006. A total of 261 respondents completed the survey. The majority (226/261 or 87%) of respondents reported having an arthritis-related condition. The consumer summary approach was generally reviewed favorably by respondents, with most agreeing that the summary provided appropriate information (177/261 or 68%), would be useful to others (160/261 or 61%), was well laid out (159/261 or 61%), was easy to learn from (157/261 or 60%), and was useful to the reader (153/261 or 59%). Areas of potential improvement were indicated by relatively fewer respondents agreeing that they could easily find all the information they wanted (118/261 or 45%), by a substantial proportion being unable to judge whether the providers of the information are reliable (80/261 or 31%), and by a similar proportion being unable to determine whether the information presented was the best available (68/261 or 26%). The CMSG has developed an approach to summarizing the results of often-technical systematic reviews into public-friendly consumer summaries. Our online survey showed that this approach was generally well liked but identified specific areas for improvement. Feedback from this survey will help to reshape and improve the current template for consumer summaries used by the CMSG.

  1. A Chandra X-Ray Census of the Interacting Binaries in Old Open Clusters—Collinder 261

    NASA Astrophysics Data System (ADS)

    Vats, Smriti; van den Berg, Maureen

    2017-03-01

    We present the first X-ray study of Collinder 261 (Cr 261), which at an age of 7 Gyr is one of the oldest open clusters known in the Galaxy. Our observation with the Chandra X-Ray Observatory is aimed at uncovering the close interacting binaries in Cr 261, and reaches a limiting X-ray luminosity of {L}X≈ 4× {10}29 {erg} {{{s}}}-1 (0.3-7 keV) for stars in the cluster. We detect 107 sources within the cluster half-mass radius r h , and we estimate that among the sources with {L}X≳ {10}30 {erg} {{{s}}}-1, ˜26 are associated with the cluster. We identify a mix of active binaries and candidate active binaries, candidate cataclysmic variables, and stars that have “straggled” from the main locus of Cr 261 in the color-magnitude diagram. Based on a deep optical source catalog of the field, we estimate that Cr 261 has an approximate mass of 6500 M ⊙, roughly the same as the old open cluster NGC 6791. The X-ray emissivity of Cr 261 is similar to that of other old open clusters, supporting the trend that they are more luminous in X-rays per unit mass than old populations of higher (globular clusters) and lower (the local neighborhood) stellar density. This implies that the dynamical destruction of binaries in the densest environments is not solely responsible for the observed differences in X-ray emissivity.

  2. 12 CFR 261a.10 - Appeal of adverse determination of request for access or amendment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Appeal of adverse determination of request for access or amendment. 261a.10 Section 261a.10 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING ACCESS TO PERSONAL INFORMATION UNDER THE PRIVACY ACT OF 1974 Procedures for Requests b...

  3. 45 CFR 261.44 - When must a State report the required data on the caseload reduction credit?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true When must a State report the required data on the caseload reduction credit? 261.44 Section 261.44 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT...

  4. 45 CFR 261.60 - What hours of participation may a State report for a work-eligible individual?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true What hours of participation may a State report for a work-eligible individual? 261.60 Section 261.60 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THA...

  5. 45 CFR 261.57 - What happens if a State sanctions a single parent of a child under six who cannot get needed...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false What happens if a State sanctions a single parent of a child under six who cannot get needed child care? 261.57 Section 261.57 Public Welfare... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Penalties...

  6. 45 CFR 261.57 - What happens if a State sanctions a single parent of a child under six who cannot get needed...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true What happens if a State sanctions a single parent of a child under six who cannot get needed child care? 261.57 Section 261.57 Public Welfare... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Penalties...

  7. 45 CFR 261.57 - What happens if a State sanctions a single parent of a child under six who cannot get needed...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false What happens if a State sanctions a single parent of a child under six who cannot get needed child care? 261.57 Section 261.57 Public Welfare... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Penalties...

  8. 45 CFR 261.57 - What happens if a State sanctions a single parent of a child under six who cannot get needed...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true What happens if a State sanctions a single parent of a child under six who cannot get needed child care? 261.57 Section 261.57 Public Welfare... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Penalties...

  9. Intracranial implantation with subsequent 3D in vivo bioluminescent imaging of murine gliomas.

    PubMed

    Abdelwahab, Mohammed G; Sankar, Tejas; Preul, Mark C; Scheck, Adrienne C

    2011-11-06

    The mouse glioma 261 (GL261) is recognized as an in vivo model system that recapitulates many of the features of human glioblastoma multiforme (GBM). The cell line was originally induced by intracranial injection of 3-methyl-cholantrene into a C57BL/6 syngeneic mouse strain (1); therefore, immunologically competent C57BL/6 mice can be used. While we use GL261, the following protocol can be used for the implantation and monitoring of any intracranial mouse tumor model. GL261 cells were engineered to stably express firefly luciferase (GL261-luc). We also created the brighter GL261-luc2 cell line by stable transfection of the luc2 gene expressed from the CMV promoter. C57BL/6-cBrd/cBrd/Cr mice (albino variant of C57BL/6) from the National Cancer Institute, Frederick, MD were used to eliminate the light attenuation caused by black skin and fur. With the use of albino C57BL/6 mice; in vivo imaging using the IVIS Spectrum in vivo imaging system is possible from the day of implantation (Caliper Life Sciences, Hopkinton, MA). The GL261-luc and GL261-luc2 cell lines showed the same in vivo behavior as the parental GL261 cells. Some of the shared histological features present in human GBMs and this mouse model include: tumor necrosis, pseudopalisades, neovascularization, invasion, hypercellularity, and inflammation (1). Prior to implantation animals were anesthetized by an intraperitoneal injection of ketamine (50 mg/kg), xylazine (5 mg/kg) and buprenorphine (0.05 mg/kg), placed in a stereotactic apparatus and an incision was made with a scalpel over the cranial midline. A burrhole was made 0.1 mm posterior to the bregma and 2.3mm to the right of the midline. A needle was inserted to a depth of 3mm and withdrawn 0.4 mm to a depth of 2.6 mm. Two μl of GL261-luc or GL261-luc2 cells (10(7) cells/ml) were infused over the course of 3 minutes. The burrhole was closed with bonewax and the incision was sutured. Following stereotactic implantation the bioluminescent cells are detectable from the day of implantation and the tumor can be analyzed using the 3D image reconstruction feature of the IVIS Spectrum instrument. Animals receive a subcutaneous injection of 150 μg luciferin /kg body weight 20 min prior to imaging. Tumor burden is quantified using mean tumor bioluminescence over time. Tumor-bearing mice were observed daily to assess morbidity and were euthanized when one or more of the following symptoms are present: lethargy, failure to ambulate, hunched posture, failure to groom, anorexia resulting in >10% loss of weight. Tumors were evident in all of the animals on necropsy.

  10. Live-cell calcium imaging of adherent and non-adherent GL261 cells reveals phenotype-dependent differences in drug responses.

    PubMed

    Strong, Averey D; Daniels, Richard L

    2017-08-02

    The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres. These different culture conditions give rise to distinct phenotypes, with increased tumorigenicity displayed by neurosphere-cultured cells. An important technique for understanding GL261 pathobiology is live cell fluorescent imaging of intracellular calcium. However, live cell imaging of GL261 neurospheres presents a technical challenge, as experimental manipulations where drugs are added to the extracellular media cause the cells to move during analysis. Here we present a method to immobilize GL261 neurospheres with low melting point agarose for calcium imaging using the fluorescent calcium sensor fura-2. GL261 cells were obtained from the NCI-Frederick Cancer Research Tumor Repository and cultured as adherent cells or induced to form neurospheres by placing freshly trypsinized cells into serum-free media containing fibroblast growth factor 2, epidermal growth factor, and B-27 supplement. Prior to experiments, adherent cells were loaded with fura-2 and cultured on 8-well chamber slides. Non-adherent neurospheres were first loaded with fura-2, placed in droplets onto an 8-well chamber slide, and finally covered with a thin layer of low melting point agarose to immobilize the cells. Ratiometric pseudocolored images were obtained during treatment with ATP, capsaicin, or vehicle control. Cells were marked as responsive if fluorescence levels increased more than 30% above baseline. Differences between treatment groups were tested using Student's t-tests and one-way ANOVA. We found that cellular responses to pharmacological treatments differ based on cellular phenotype. Adherent cells and neurospheres both responded to ATP with a rise in intracellular calcium. Notably, capsaicin treatment led to robust responses in GL261 neurospheres but not adherent cells. We demonstrate the use of low melting point agarose for immobilizing GL261 cells, a method that is broadly applicable to any cell type cultured in suspension, including acutely trypsinized cells and primary tumor cells. Our results indicate that it is important to consider GL261 phenotype (adherent or neurosphere) when interpreting data regarding physiological responses to experimental compounds.

  11. Recruited brain tumor-derived mesenchymal stem cells contribute to brain tumor progression.

    PubMed

    Behnan, Jinan; Isakson, Pauline; Joel, Mrinal; Cilio, Corrado; Langmoen, Iver A; Vik-Mo, Einar O; Badn, Wiaam

    2014-05-01

    The identity of the cells that contribute to brain tumor structure and progression remains unclear. Mesenchymal stem cells (MSCs) have recently been isolated from normal mouse brain. Here, we report the infiltration of MSC-like cells into the GL261 murine glioma model. These brain tumor-derived mesenchymal stem cells (BT-MSCs) are defined with the phenotype (Lin-Sca-1+CD9+CD44+CD166+/-) and have multipotent differentiation capacity. We show that the infiltration of BT-MSCs correlates to tumor progression; furthermore, BT-MSCs increased the proliferation rate of GL261 cells in vitro. For the first time, we report that the majority of GL261 cells expressed mesenchymal phenotype under both adherent and sphere culture conditions in vitro and that the non-MSC population is nontumorigenic in vivo. Although the GL261 cell line expressed mesenchymal phenotype markers in vitro, most BT-MSCs are recruited cells from host origin in both wild-type GL261 inoculated into green fluorescent protein (GFP)-transgenic mice and GL261-GFP cells inoculated into wild-type mice. We show the expression of chemokine receptors CXCR4 and CXCR6 on different recruited cell populations. In vivo, the GL261 cells change marker profile and acquire a phenotype that is more similar to cells growing in sphere culture conditions. Finally, we identify a BT-MSC population in human glioblastoma that is CD44+CD9+CD166+ both in freshly isolated and culture-expanded cells. Our data indicate that cells with MSC-like phenotype infiltrate into the tumor stroma and play an important role in tumor cell growth in vitro and in vivo. Thus, we suggest that targeting BT-MSCs could be a possible strategy for treating glioblastoma patients. © 2013 AlphaMed Press.

  12. 40 CFR Appendix Vi to Part 261 - Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND LISTING OF HAZARDOUS WASTE Financial Requirements for Management of Excluded Hazardous Secondary Materials Wording of the instruments. Appendix VI to Part 261 [Reserved for Etiologic Agents] ...

  13. 15 CFR 904.261 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Post-Hearing § 904.261 Post-hearing briefs. (a) The parties may file...

  14. 15 CFR 904.261 - Post-hearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Post-Hearing § 904.261 Post-hearing briefs. (a) The parties may file...

  15. 50 CFR 648.261 - Framework adjustment process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.261 Framework adjustment process. (a) To...

  16. 36 CFR 261.50 - Orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in Areas Designated by Order § 261.50 Orders. (a) The Chief, each Regional Forester, each Experiment... Forester, each Experiment Station Director, the Administrator of the Lake Tahoe Basin Management Unit and...

  17. 40 CFR Appendix IV to Part 261 - Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND LISTING OF HAZARDOUS WASTE Financial Requirements for Management of Excluded Hazardous Secondary Materials Wording of the instruments. Appendix IV to Part 261 [Reserved for Radioactive Waste Test Methods] ...

  18. 36 CFR 261.50 - Orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in Areas Designated by Order § 261.50 Orders. (a) The Chief, each Regional Forester, each Experiment... Forester, each Experiment Station Director, the Administrator of the Lake Tahoe Basin Management Unit and...

  19. 36 CFR 261.50 - Orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in Areas Designated by Order § 261.50 Orders. (a) The Chief, each Regional Forester, each Experiment... Forester, each Experiment Station Director, the Administrator of the Lake Tahoe Basin Management Unit and...

  20. 36 CFR 261.50 - Orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in Areas Designated by Order § 261.50 Orders. (a) The Chief, each Regional Forester, each Experiment... Forester, each Experiment Station Director, the Administrator of the Lake Tahoe Basin Management Unit and...

  1. 24 CFR 241.261 - Payment of insurance benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES SUPPLEMENTARY FINANCING FOR INSURED PROJECT MORTGAGES Contract Rights and Obligations § 241.261... shall be paid in cash if insurance benefits under the insured project mortgage are payable in cash...

  2. 39 CFR 261.4 - Responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.4... President and Consumer Advocate, is responsible for administering records and information management.... (c) Postal Service managers are responsible for administering records and information management...

  3. 39 CFR 261.4 - Responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.4... President and Consumer Advocate, is responsible for administering records and information management.... (c) Postal Service managers are responsible for administering records and information management...

  4. 39 CFR 261.4 - Responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.4... President and Consumer Advocate, is responsible for administering records and information management.... (c) Postal Service managers are responsible for administering records and information management...

  5. 39 CFR 261.4 - Responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.4... President and Consumer Advocate, is responsible for administering records and information management.... (c) Postal Service managers are responsible for administering records and information management...

  6. 39 CFR 261.4 - Responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.4... President and Consumer Advocate, is responsible for administering records and information management.... (c) Postal Service managers are responsible for administering records and information management...

  7. 27 CFR 46.261 - Purpose of an alternate method or procedure.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Alternate Methods Or Procedures § 46.261...

  8. 27 CFR 46.261 - Purpose of an alternate method or procedure.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Alternate Methods Or Procedures § 46.261...

  9. 27 CFR 46.261 - Purpose of an alternate method or procedure.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Alternate Methods Or Procedures § 46.261...

  10. 12 CFR 261.12 - Records available to public upon request.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Available to Public; Procedures for Requests § 261.12 Records available to public upon request. (a) Types of... scientific institution, or news media representative; (3) A statement agreeing to pay the applicable fees, or...

  11. 12 CFR 261.12 - Records available to public upon request.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Available to Public; Procedures for Requests § 261.12 Records available to public upon request. (a) Types of... scientific institution, or news media representative; (3) A statement agreeing to pay the applicable fees, or...

  12. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CFR part 266, subpart F); (iv) Spent lead-acid batteries that are being reclaimed (40 CFR part 266... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  13. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CFR part 266, subpart F); (iv) Spent lead-acid batteries that are being reclaimed (40 CFR part 266... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  14. 27 CFR 46.261 - Purpose of an alternate method or procedure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Alternate Methods Or Procedures § 46.261...

  15. 27 CFR 46.261 - Purpose of an alternate method or procedure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Alternate Methods Or Procedures § 46.261...

  16. 40 CFR 266.210 - What definitions apply to this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waste described in 40 CFR 261.3. Hazardous Waste means any material which is defined to be hazardous waste in accordance with 40 CFR 261.3, “Definition of Hazardous Waste.” Land Disposal Restriction (LDR...

  17. Turbidity monitoring equipment and methodology evaluation at MDOT construction sites.

    DOT National Transportation Integrated Search

    2014-12-01

    State Study 261 is a continuation of State study 225, "Turbidity Monitoring at Select : MDOT Construction Sites", which was successful in establishing baseline stream data : at several active construction sites. State Study 261 focused on the equipme...

  18. 47 CFR 87.261 - Scope of service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Aeronautical Enroute and Aeronautical Fixed Stations Aeronautical Enroute Stations § 87.261 Scope of service. (a) Aeronautical enroute stations provide operational control communications to aircraft along... aircraft station licensee who makes cooperative arrangements for the operation, maintenance and liability...

  19. 47 CFR 87.261 - Scope of service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Aeronautical Enroute and Aeronautical Fixed Stations Aeronautical Enroute Stations § 87.261 Scope of service. (a) Aeronautical enroute stations provide operational control communications to aircraft along... aircraft station licensee who makes cooperative arrangements for the operation, maintenance and liability...

  20. 47 CFR 87.261 - Scope of service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Aeronautical Enroute and Aeronautical Fixed Stations Aeronautical Enroute Stations § 87.261 Scope of service. (a) Aeronautical enroute stations provide operational control communications to aircraft along... aircraft station licensee who makes cooperative arrangements for the operation, maintenance and liability...

  1. 261. JEHOVAH'S WITNESSES HALL AT 1718, NORTH FRONT AND EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    261. JEHOVAH'S WITNESSES HALL AT 1718, NORTH FRONT AND EAST SIDE, TOWARD SOUTHWEST, RUSSELL JUNIOR HIGH SCHOOL (RUSSELL APARTMENTS) IN BACKGROUND - Russell Neighborhood, Bounded by Congress & Esquire Alley, Fifteenth & Twenty-first Streets, Louisville, Jefferson County, KY

  2. 20 CFR 632.261 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.261 Reporting requirements. (a) Each Native American grantee shall submit an end of summer report which will include both... than 45 days after the end of the summer program. ...

  3. 20 CFR 632.261 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.261 Reporting requirements. (a) Each Native American grantee shall submit an end of summer report which will include both... than 45 days after the end of the summer program. ...

  4. 20 CFR 632.261 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.261 Reporting requirements. (a) Each Native American grantee shall submit an end of summer report which will include both... than 45 days after the end of the summer program. ...

  5. 77 FR 1777 - 60-Day Notice of Proposed Information Collection: DS-261, Electronic Choice of Address and Agent...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Consular Affairs, Visa Services (CA/VO/L/R). Form Number: DS-261. Respondents: Immigrant beneficiaries... immigrant visa petition to provide the Department with his current address, which will be used for...

  6. 40 CFR 60.261 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... electric submerged arc furnace to become subject to a different mass standard applicable under this subpart... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Ferroalloy Production Facilities § 60.261...

  7. 40 CFR 60.261 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... electric submerged arc furnace to become subject to a different mass standard applicable under this subpart... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Ferroalloy Production Facilities § 60.261...

  8. 40 CFR 60.261 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... electric submerged arc furnace to become subject to a different mass standard applicable under this subpart... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Ferroalloy Production Facilities § 60.261...

  9. 40 CFR 60.261 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... electric submerged arc furnace to become subject to a different mass standard applicable under this subpart... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Ferroalloy Production Facilities § 60.261...

  10. 40 CFR 60.261 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... electric submerged arc furnace to become subject to a different mass standard applicable under this subpart... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Ferroalloy Production Facilities § 60.261...

  11. Epidemiology of hospital admissions for chickenpox in children: an Italian multicentre study in the pre-vaccine era.

    PubMed

    Marchetto, S; de Benedictis, F M; de Martino, M; Versace, A; Chiappini, E; Bertaine, C; Osimani, P; Cordiali, R; Gabiano, C; Galli, L

    2007-10-01

    To describe the chickenpox complications in children in Italy. Hospital discharge data from 1 January 2002 to 15 June 2006 were queried for patients less than 18 years of age in three Italian paediatric university hospitals. During the study period, 349 children (189 males, 160 females) were admitted. Thirteen out of 349 (3.7%) of them had serious underlying diseases. Two hundred and sixty-one (74.8%) children (median age: 41 months, range: 6 days -to 200 months) had complicated chickenpox. Among complications, neurological disorders were the most common (100/261 = 38.3%), followed by skin and soft tissue infections (63/261 = 24.1%), lower respiratory tract infections (57/261 = 21.8%) and haematological disorders (24/261 = 9.2%). Children with neurological complications were significantly older and had a longer hospital stay than those with other complications. Three children with encephalitis and cerebellitis had developed long-term sequelae by the 6-month follow-up. The mortality rate was 0.4% (1/261 children with complicated chickenpox). Chickenpox is a disease that can provoke serious complications and long hospital stays, even in healthy children. Our findings may be useful as background to evaluate the impact of a tetravalent measles-mumps-rubella-varicella vaccine (MMRV) which is going to be introduced in Italy.

  12. Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.

    PubMed Central

    Trapani, J A; Klein, J L; White, P C; Dupont, B

    1988-01-01

    A cDNA clone encoding a human serine esterase gene was isolated from a library constructed from poly(A)+ RNA of allogeneically stimulated, interleukin 2-expanded peripheral blood mononuclear cells. The clone, designated HSE26.1, represents a full-length copy of a 0.9-kilobase mRNA present in human cytotoxic cells but absent from a wide variety of noncytotoxic cell lines. Clone HSE26.1 contains an 892-base-pair sequence, including a single 741-base-pair open reading frame encoding a putative 247-residue polypeptide. The first 20 amino acids of the polypeptide form a leader sequence. The mature protein is predicted to have an unglycosylated Mr of approximately equal to 26,000 and contains a single potential site for N-linked glycosylation. The nucleotide and predicted amino acid sequences of clone HSE26.1 are homologous with all murine and human serine esterases cloned thus far but are most similar to mouse granzyme B (70% nucleotide and 68% amino acid identity). HSE26.1 protein is expressed weakly in unstimulated peripheral blood mononuclear cells but is strongly induced within 6-hr incubation in medium containing phytohemagglutinin. The data suggest that the protein encoded by HSE26.1 plays a role in cell-mediated cytotoxicity. Images PMID:3261871

  13. 27 CFR 25.261 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY LIQUORS BEER Beer Concentrate § 25.261 General. (a) Authorized processes. A brewer may, in accordance with this subpart— (1) Produce concentrate from beer, (2) Reconstitute beer from concentrate, (3... treatment of concentrate. Beer reconstituted from concentrate in accordance with this subpart shall (except...

  14. 27 CFR 25.261 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY ALCOHOL BEER Beer Concentrate § 25.261 General. (a) Authorized processes. A brewer may, in accordance with this subpart— (1) Produce concentrate from beer, (2) Reconstitute beer from concentrate, (3... treatment of concentrate. Beer reconstituted from concentrate in accordance with this subpart shall (except...

  15. 27 CFR 25.261 - General.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY LIQUORS BEER Beer Concentrate § 25.261 General. (a) Authorized processes. A brewer may, in accordance with this subpart— (1) Produce concentrate from beer, (2) Reconstitute beer from concentrate, (3... treatment of concentrate. Beer reconstituted from concentrate in accordance with this subpart shall (except...

  16. 27 CFR 25.261 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY ALCOHOL BEER Beer Concentrate § 25.261 General. (a) Authorized processes. A brewer may, in accordance with this subpart— (1) Produce concentrate from beer, (2) Reconstitute beer from concentrate, (3... treatment of concentrate. Beer reconstituted from concentrate in accordance with this subpart shall (except...

  17. 12 CFR 261.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... conducting scientific research, the results of which are not intended to promote any particular product or... scholarly research. (g) Exempt information means information that is exempt from disclosure under § 261.14. (h) Noncommercial scientific institution refers to an institution that is not operated on a...

  18. 77 FR 28922 - 30-Day Notice of Proposed Information Collection: DS-261, Electronic Choice of Address and Agent...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    .... Originating Office: CA/VO/L/R. Form Number: DS-261. Respondents: Immigrant beneficiaries requesting change of... allows the beneficiary of an approved immigrant visa petition to provide the Department with his current...

  19. 40 CFR 261.22 - Characteristic of corrosivity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 261.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Characteristic of corrosivity. (a) A solid waste exhibits the characteristic of corrosivity if a representative... Methods for Evaluating Solid Waste, Physical/Chemical Methods,” EPA Publication SW-846, as incorporated by...

  20. 36 CFR 261.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... beneath the surface of the earth or within a cliff or ledge and which is large enough to permit a person... and communication bridges between various socioeconomic groups; and further the administration... General Prohibitions § 261.2 Definitions. The following definitions apply to this part: Administrative...

  1. 36 CFR 261.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... beneath the surface of the earth or within a cliff or ledge and which is large enough to permit a person... and communication bridges between various socioeconomic groups; and further the administration... General Prohibitions § 261.2 Definitions. The following definitions apply to this part: Administrative...

  2. 47 CFR 87.261 - Scope of service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Aeronautical Enroute Stations, Aeronautical Fixed Stations, and Aircraft Data Link Land Test Stations Aeronautical Enroute Stations § 87.261 Scope of service. (a) Aeronautical enroute stations provide operational.... (b) Service must be provided to any aircraft station licensee who makes cooperative arrangements for...

  3. 27 CFR 25.261 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY LIQUORS BEER Beer Concentrate § 25.261 General. (a) Authorized processes. A brewer may, in accordance with this subpart— (1) Produce concentrate from beer, (2) Reconstitute beer from concentrate, (3... treatment of concentrate. Beer reconstituted from concentrate in accordance with this subpart shall (except...

  4. 40 CFR 261.4 - Exclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... exclusion from the definition of solid waste. (18) Petrochemical recovered oil from an associated organic... for benzene (§ 261.24, waste code D018); and (ii) The oil generated by the organic chemical... petroleum refining process. An “associated organic chemical manufacturing facility” is a facility where the...

  5. 45 CFR 261.2 - What definitions apply to this part?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 261.2 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT.... (g) Job search and job readiness assistance means the act of seeking or obtaining employment...

  6. 45 CFR 261.2 - What definitions apply to this part?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 261.2 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT.... (g) Job search and job readiness assistance means the act of seeking or obtaining employment...

  7. 45 CFR 261.2 - What definitions apply to this part?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 261.2 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT.... (g) Job search and job readiness assistance means the act of seeking or obtaining employment...

  8. 18 CFR 284.261 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF ENERGY OTHER REGULATIONS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES CERTAIN SALES AND TRANSPORTATION OF NATURAL GAS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES Emergency Natural Gas Sale, Transportation, and Exchange Transactions § 284.261 Purpose. This subpart...

  9. 40 CFR 180.261 - Phosmet; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Phosmet; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.261 Phosmet; tolerances for residues. (a) General. Tolerances are established for residues of the insecticide...

  10. 261. Photocopy of drawing (1976 electrical drawing by the Space ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    261. Photocopy of drawing (1976 electrical drawing by the Space and Missile Test Center, VAFB, USAF) FLOODLIGHT PLAN FOR LAUNCH PAD AREA, SHEET E9 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  11. 45 CFR 261.10 - What work requirements must an individual meet?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual Responsibility? § 261.10 What work requirements must an individual meet? (a)(1) A parent or caretaker receiving assistance must...

  12. 45 CFR 261.10 - What work requirements must an individual meet?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual Responsibility? § 261.10 What work requirements must an individual meet? (a)(1) A parent or caretaker receiving assistance...

  13. 45 CFR 261.10 - What work requirements must an individual meet?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual Responsibility? § 261.10 What work requirements must an individual meet? (a)(1) A parent or caretaker receiving assistance...

  14. 45 CFR 261.10 - What work requirements must an individual meet?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual Responsibility? § 261.10 What work requirements must an individual meet? (a)(1) A parent or caretaker receiving assistance...

  15. 45 CFR 261.10 - What work requirements must an individual meet?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual Responsibility? § 261.10 What work requirements must an individual meet? (a)(1) A parent or caretaker receiving assistance must...

  16. 12 CFR 261.10 - Published information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Publications Services, Board of Governors of the Federal Reserve System, 20th Street and Constitution Avenue, N... Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM...; Procedures for Requests § 261.10 Published information. (a) Federal Register. The Board publishes in the...

  17. 20 CFR 404.261 - Computing your special minimum primary insurance amount.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Computing your special minimum primary..., SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts Special Minimum Primary Insurance Amounts § 404.261 Computing your special minimum primary insurance amount. (a) Years of coverage...

  18. 9 CFR 319.261 - Meat loaf.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Luncheon Meat, Loaves and Jellied Products § 319.261 Meat loaf. “Meat Loaf” is a cooked meat food product in loaf form made from comminuted meat...

  19. 9 CFR 319.261 - Meat loaf.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Luncheon Meat, Loaves and Jellied Products § 319.261 Meat loaf. “Meat Loaf” is a cooked meat food product in loaf form made from comminuted meat...

  20. 36 CFR 261.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... beneath the surface of the earth or within a cliff or ledge and which is large enough to permit a person... of the United States, national forest lands and waters acquired through purchase, exchange, donation... General Prohibitions § 261.2 Definitions. The following definitions apply to this part: Administrative...

  1. 45 CFR 260.72 - What basic requirements must State demonstration components meet for the purpose of determining...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of cases specified in the waiver approval package. (c) The State must have applied its waiver... work or time-limit penalties at §§ 261.50, 261.54, and 264.1 of this chapter or the data collection...

  2. 45 CFR 260.72 - What basic requirements must State demonstration components meet for the purpose of determining...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of cases specified in the waiver approval package. (c) The State must have applied its waiver... work or time-limit penalties at §§ 261.50, 261.54, and 264.1 of this chapter or the data collection...

  3. 40 CFR Appendix I to Part 261 - Representative Sampling Methods

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Representative Sampling Methods I Appendix I to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...—Representative Sampling Methods The methods and equipment used for sampling waste materials will vary with the...

  4. 12 CFR 261a.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGARDING ACCESS TO PERSONAL INFORMATION UNDER THE PRIVACY ACT 1974 General Provisions § 261a.2 Definitions... Saturday, Sunday or a legal Federal holiday. (b) Guardian means the parent of a minor, or the legal... particular assigned to the individual. (h) You means an individual making a request under the Privacy Act. (i...

  5. 40 CFR 268.37 - Waste specific prohibitions-ignitable and corrosive characteristic wastes whose treatment...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in 40 CFR 261.21 as D001 (and is not in the High TOC Ignitable Liquids Subcategory), and specified in... specified in 40 CFR 261.21 as D001 (and is not in the High TOC Ignitable Liquids Subcategory), and specified...

  6. 36 CFR 261.53 - Special closures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Prohibitions in Areas Designated by Order § 261.53 Special closures. When provided in an order, it is prohibited to go into or be upon any area which is closed for the protection of: (a) Threatened, endangered... communities. (c) Objects or areas of historical, archeological, geological, or paleontological interest. (d...

  7. Publications - GMC 261 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ') of the ARCO Alaska Inc. Jones Island #1 well Authors: Unknown Publication Date: 1996 Publisher well: Alaska Division of Geological & Geophysical Surveys Geologic Materials Center Data Report 261

  8. 12 CFR 261b.11 - Transcripts, recordings, and minutes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... minutes. (a) The agency will maintain a complete transcript or electronic recording or transcription... § 261b.5 of this part. Transcriptions of recordings will disclose the identity of each speaker. (b) The agency will maintain either such a transcript, recording or transcription thereof, or a set of minutes...

  9. 40 CFR 262.34 - Accumulation time.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (1) The waste is placed: (i) In containers and the generator complies with the applicable... for inspection on each container; (3) While being accumulated on-site, each container and tank is... listed in § 261.31 or § 261.33(e) in containers at or near any point of generation where wastes initially...

  10. 40 CFR 262.34 - Accumulation time.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...: (1) The waste is placed: (i) In containers and the generator complies with the applicable... for inspection on each container; (3) While being accumulated on-site, each container and tank is... listed in § 261.31 or § 261.33(e) in containers at or near any point of generation where wastes initially...

  11. 40 CFR 262.34 - Accumulation time.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...: (1) The waste is placed: (i) In containers and the generator complies with the applicable... for inspection on each container; (3) While being accumulated on-site, each container and tank is... listed in § 261.31 or § 261.33(e) in containers at or near any point of generation where wastes initially...

  12. 40 CFR 262.34 - Accumulation time.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...: (1) The waste is placed: (i) In containers and the generator complies with the applicable... for inspection on each container; (3) While being accumulated on-site, each container and tank is... listed in § 261.31 or § 261.33(e) in containers at or near any point of generation where wastes initially...

  13. 40 CFR 262.34 - Accumulation time.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...: (1) The waste is placed: (i) In containers and the generator complies with the applicable... for inspection on each container; (3) While being accumulated on-site, each container and tank is... listed in § 261.31 or § 261.33(e) in containers at or near any point of generation where wastes initially...

  14. 76 FR 9020 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... -------- Preparation and Submission of Data 54 1 640 34,560 Verification Procedures--Sec. Sec. 261.60-261.63 Caseload... for Needy Families (TANF) program, it imposed a new data requirement that States prepare and submit data verification procedures and replaced other data requirements with new versions including: the TANF...

  15. 40 CFR 261.147 - Liability requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... facility subject to financial assurance requirements under § 261.4(a)(24)(vi)(F) of this chapter, or a... financial assurances under this paragraph, the owner or operator shall specify at least one such assurance as “primary” coverage and shall specify other assurance as “excess” coverage. (7) An owner or...

  16. 36 CFR 261.55 - National Forest System trails.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest System trails... PROHIBITIONS Prohibitions in Areas Designated by Order § 261.55 National Forest System trails. When provided by... National Forest System trail: (a) Being on a trail. (b) Using any type of vehicle prohibited by the order...

  17. Evolution in a Test Tube: Exploring the Structure and Function of RNA Probes

    DTIC Science & Technology

    2008-05-02

    Bartel, D.P. and Szostak, J.W. (1993) Isolation of New Ribozymes from a Large Pool of Random Sequences. Science, New Series 261, 1141-1418. 24...Szostak, J.W. (1993) Isolation of New Ribozymes from a Large Pool of Random Sequences. Science, New Series 261, 1141-1418. Chen, Ying; Carlini

  18. 12 CFR 261a.5 - Request for access to records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Federal Reserve System, 20th Street and Constitution Avenue, NW., Washington, DC 20551. (2) If you request... 261a.5 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE... writing to the Inspector General, Board of Governors of the Federal Reserve System, 20th Street and...

  19. 40 CFR 261.141 - Definitions of terms as used in this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Financial Requirements for Management of Excluded Hazardous Secondary Materials § 261.141 Definitions of terms as used in this subpart... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Definitions of terms as used in this...

  20. 36 CFR 261.23 - Wild free-roaming horses and burros.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Wild free-roaming horses and... AGRICULTURE PROHIBITIONS General Prohibitions § 261.23 Wild free-roaming horses and burros. The following are prohibited: (a) Removing or attempting to remove a wild free-roaming horse or burro from the National Forest...

  1. 40 CFR 265.340 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (b) Integration of the MACT standards. (1) Except as provided by paragraphs (b)(2) and (b)(3) of this... 261, subpart D, of this chapter solely because it is ignitable (Hazard Code I), corrosive (Hazard Code... because it is reactive (Hazard Code R) for characteristics other than those listed in § 261.23(a) (4) and...

  2. 40 CFR 265.340 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... (b) Integration of the MACT standards. (1) Except as provided by paragraphs (b)(2) and (b)(3) of this... 261, subpart D, of this chapter solely because it is ignitable (Hazard Code I), corrosive (Hazard Code... because it is reactive (Hazard Code R) for characteristics other than those listed in § 261.23(a) (4) and...

  3. 40 CFR 264.340 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Integration of the MACT standards. (1) Except as provided by paragraphs (b)(2) through (b)(4) of this section... hazardous waste in part 261, subpart D, of this chapter solely because it is ignitable (Hazard Code I... chapter solely because it is reactive (Hazard Code R) for characteristics other than those listed in § 261...

  4. 40 CFR 265.340 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (b) Integration of the MACT standards. (1) Except as provided by paragraphs (b)(2) and (b)(3) of this... 261, subpart D, of this chapter solely because it is ignitable (Hazard Code I), corrosive (Hazard Code... because it is reactive (Hazard Code R) for characteristics other than those listed in § 261.23(a) (4) and...

  5. 36 CFR 261.23 - Wild free-roaming horses and burros.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Wild free-roaming horses and... AGRICULTURE PROHIBITIONS General Prohibitions § 261.23 Wild free-roaming horses and burros. The following are prohibited: (a) Removing or attempting to remove a wild free-roaming horse or burro from the National Forest...

  6. 36 CFR 261.23 - Wild free-roaming horses and burros.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Wild free-roaming horses and... AGRICULTURE PROHIBITIONS General Prohibitions § 261.23 Wild free-roaming horses and burros. The following are prohibited: (a) Removing or attempting to remove a wild free-roaming horse or burro from the National Forest...

  7. 36 CFR 261.23 - Wild free-roaming horses and burros.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Wild free-roaming horses and... AGRICULTURE PROHIBITIONS General Prohibitions § 261.23 Wild free-roaming horses and burros. The following are prohibited: (a) Removing or attempting to remove a wild free-roaming horse or burro from the National Forest...

  8. 36 CFR 261.23 - Wild free-roaming horses and burros.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Wild free-roaming horses and... AGRICULTURE PROHIBITIONS General Prohibitions § 261.23 Wild free-roaming horses and burros. The following are prohibited: (a) Removing or attempting to remove a wild free-roaming horse or burro from the National Forest...

  9. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and electric...

  10. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and electric...

  11. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and electric...

  12. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and electric...

  13. 40 CFR 96.262 - Notification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR SO2 Allowance... CAIR SO2 allowance transfer under § 96.261, the Administrator will notify the CAIR authorized account... business days of receipt of a CAIR SO2 allowance transfer that fails to meet the requirements of § 96.261(a...

  14. 50 CFR 648.261 - Framework adjustment process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.261 Framework adjustment process. (a) To implement a framework adjustment for the Red Crab FMP, the Council shall develop and analyze proposed... Administrator. (1) In response to an annual review of the status of the fishery or the resource by the Red Crab...

  15. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and electric...

  16. 36 CFR 261.50 - Orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in Areas Designated by Order § 261.50 Orders. (a) The Chief, each Regional Forester, each Experiment... issue orders which close or restrict the use of described areas within the area over which he has jurisdiction. An order may close an area to entry or may restrict the use of an area by applying any or all of...

  17. 40 CFR 261.31 - Hazardous wastes from non-specific sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... landfill for disposal and are either: disposed in a Subtitle D municipal or industrial landfill unit that...; or disposed in a landfill unit subject to, or otherwise meeting, the landfill requirements in § 258... processing or recycling oil-bearing hazardous secondary materials excluded under § 261.4(a)(12)(i), if those...

  18. 40 CFR Appendix I to Part 264 - Recordkeeping Instructions

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...., liquid, sludge, solid, or contained gas. If the waste is not listed in part 261, subpart D, of this... from production of ----, EPA Hazardous Waste Number W051). Each hazardous waste listed in part 261... Methods Enter the handling code(s) listed below that most closely represents the technique(s) used at the...

  19. 36 CFR 261.12 - National Forest System roads and trails.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... by a sign. (c) Damaging and leaving in a damaged condition any such road, trail, or segment thereof... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false National Forest System roads... AGRICULTURE PROHIBITIONS General Prohibitions § 261.12 National Forest System roads and trails. The following...

  20. 36 CFR 261.12 - National Forest System roads and trails.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... by a sign. (c) Damaging and leaving in a damaged condition any such road, trail, or segment thereof... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest System roads... AGRICULTURE PROHIBITIONS General Prohibitions § 261.12 National Forest System roads and trails. The following...

  1. 36 CFR 261.12 - National Forest System roads and trails.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... by a sign. (c) Damaging and leaving in a damaged condition any such road, trail, or segment thereof... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false National Forest System roads... AGRICULTURE PROHIBITIONS General Prohibitions § 261.12 National Forest System roads and trails. The following...

  2. 36 CFR 261.12 - National Forest System roads and trails.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... by a sign. (c) Damaging and leaving in a damaged condition any such road, trail, or segment thereof... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false National Forest System roads... AGRICULTURE PROHIBITIONS General Prohibitions § 261.12 National Forest System roads and trails. The following...

  3. 36 CFR 261.12 - National Forest System roads and trails.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... by a sign. (c) Damaging and leaving in a damaged condition any such road, trail, or segment thereof... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false National Forest System roads... AGRICULTURE PROHIBITIONS General Prohibitions § 261.12 National Forest System roads and trails. The following...

  4. 45 CFR 261.51 - Under what circumstances will we reduce the amount of the penalty below the maximum?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Penalties Apply to States Related to Work Requirements? § 261.51 Under what circumstances will we reduce the amount of the penalty...

  5. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., following its original use, for any purpose (including the purpose for which the oil was originally used...)) for purpose of recovery is subject to the requirements of 40 CFR part 262, subpart H, if it is subject... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  6. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., following its original use, for any purpose (including the purpose for which the oil was originally used...)) for purpose of recovery is subject to the requirements of 40 CFR part 262, subpart H, if it is subject... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  7. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., following its original use, for any purpose (including the purpose for which the oil was originally used...)) for purpose of recovery is subject to the requirements of 40 CFR part 262, subpart H, if it is subject... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  8. 36 CFR 261.54 - National Forest System roads.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest System roads... PROHIBITIONS Prohibitions in Areas Designated by Order § 261.54 National Forest System roads. When provided by...) Use by any type of traffic prohibited by the order. (c) Using a road for commercial hauling without a...

  9. 36 CFR 261.15 - Use of vehicles off roads.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Use of vehicles off roads... PROHIBITIONS General Prohibitions § 261.15 Use of vehicles off roads. It is prohibited to operate any vehicle off National Forest System, State or County roads: (a) Without a valid license as required by State...

  10. 36 CFR 261.54 - National Forest System roads.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false National Forest System roads... PROHIBITIONS Prohibitions in Areas Designated by Order § 261.54 National Forest System roads. When provided by...) Use by any type of traffic prohibited by the order. (c) Using a road for commercial hauling without a...

  11. 36 CFR 261.15 - Use of vehicles off roads.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Use of vehicles off roads... PROHIBITIONS General Prohibitions § 261.15 Use of vehicles off roads. It is prohibited to operate any vehicle off National Forest System, State or County roads: (a) Without a valid license as required by State...

  12. 28 CFR 115.261 - Staff and agency reporting duties.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Staff and agency reporting duties. 115... Resident Report § 115.261 Staff and agency reporting duties. (a) The agency shall require all staff to... agency; retaliation against residents or staff who reported such an incident; and any staff neglect or...

  13. 28 CFR 115.261 - Staff and agency reporting duties.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Staff and agency reporting duties. 115... Resident Report § 115.261 Staff and agency reporting duties. (a) The agency shall require all staff to... agency; retaliation against residents or staff who reported such an incident; and any staff neglect or...

  14. 28 CFR 115.261 - Staff and agency reporting duties.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Staff and agency reporting duties. 115... Resident Report § 115.261 Staff and agency reporting duties. (a) The agency shall require all staff to... agency; retaliation against residents or staff who reported such an incident; and any staff neglect or...

  15. 40 CFR 268.34 - Waste specific prohibitions-toxicity characteristic metal wastes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Prohibitions on Land Disposal § 268.34 Waste... wastes are prohibited from land disposal: the wastes specified in 40 CFR Part 261 as EPA Hazardous Waste... 261. (b) Effective November 26, 1998, the following waste is prohibited from land disposal: Slag from...

  16. 40 CFR 268.34 - Waste specific prohibitions-toxicity characteristic metal wastes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Prohibitions on Land Disposal § 268.34 Waste... wastes are prohibited from land disposal: the wastes specified in 40 CFR Part 261 as EPA Hazardous Waste... 261. (b) Effective November 26, 1998, the following waste is prohibited from land disposal: Slag from...

  17. 40 CFR 268.34 - Waste specific prohibitions-toxicity characteristic metal wastes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Prohibitions on Land Disposal § 268.34 Waste... wastes are prohibited from land disposal: the wastes specified in 40 CFR Part 261 as EPA Hazardous Waste... 261. (b) Effective November 26, 1998, the following waste is prohibited from land disposal: Slag from...

  18. Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.

    PubMed

    Kober, Christina; Weibel, Stephanie; Rohn, Susanne; Kirscher, Lorenz; Szalay, Aladar A

    2015-01-01

    Oncolytic vaccinia virus (VACV) therapy is an alternative treatment option for glioblastoma multiforme. Here, we used a comparison of different tumor locations and different immunologic and genetic backgrounds to determine the replication efficacy and oncolytic potential of the VACV LIVP 1.1.1, an attenuated wild-type isolate of the Lister strain, in murine GL261 glioma models. With this approach, we expected to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy. We found that GL261 glioma cells implanted subcutaneously or orthotopically into Balb/c athymic, C57BL/6 athymic, or C57BL/6 wild-type mice formed individual tumors that respond to oncolytic VACV therapy with different outcomes. Surprisingly, only Balb/c athymic mice with subcutaneous tumors supported viral replication. We identified intratumoral IFN-γ expression levels that upregulate MHCII expression on GL261 cells in C57BL/6 wild-type mice associated with a non-permissive status of the tumor cells. Moreover, this IFN-γ-induced tumor cell phenotype was reversible.

  19. Complete genome sequence of uropathogenic Escherichia coli isolate UPEC 26-1.

    PubMed

    Subhadra, Bindu; Kim, Dong Ho; Kim, Jaeseok; Woo, Kyungho; Sohn, Kyung Mok; Kim, Hwa-Jung; Han, Kyudong; Oh, Man Hwan; Choi, Chul Hee

    2018-06-01

    Urinary tract infections (UTIs) are among the most common infections in humans, predominantly caused by uropathogenic Escherichia coli (UPEC). The diverse genomes of UPEC strains mostly impede disease prevention and control measures. In this study, we comparatively analyzed the whole genome sequence of a highly virulent UPEC strain, namely UPEC 26-1, which was isolated from urine sample of a patient suffering from UTI in Korea. Whole genome analysis showed that the genome consists of one circular chromosome of 5,329,753 bp, comprising 5064 protein-coding genes, 122 RNA genes (94 tRNA, 22 rRNA and 6 ncRNA genes), and 100 pseudogenes, with an average G+C content of 50.56%. In addition, we identified 8 prophage regions comprising 5 intact, 2 incomplete and 1 questionable ones and 63 genomic islands, suggesting the possibility of horizontal gene transfer in this strain. Comparative genome analysis of UPEC 26-1 with the UPEC strain CFT073 revealed an average nucleotide identity of 99.7%. The genome comparison with CFT073 provides major differences in the genome of UPEC 26-1 that would explain its increased virulence and biofilm formation. Nineteen of the total GIs were unique to UPEC 26-1 compared to CFT073 and nine of them harbored unique genes that are involved in virulence, multidrug resistance, biofilm formation and bacterial pathogenesis. The data from this study will assist in future studies of UPEC strains to develop effective control measures.

  20. Association of Kidney Function and Waist Circumference with Uric Acid Levels in South Africans.

    PubMed

    Madala, Nomandla Daphne; Dubula, Thozama; Assounga, Alain Guy Honoré; Naicker, Saraladevi

    2017-12-01

    Recent evidence that hyperuricemia is associated with incident chronic kidney disease (CKD) provides a potential therapeutic target for CKD that has not been explored in Africans. With hyperuricemia and gout increasing globally, we sought to determine their prevalence in South Africans with varying kidney function levels. This was a cross-sectional study of ambulatory adult patients presenting at a General Internal Medicine Outpatients Clinic between September 2012 and March 2014. Demographic, clinical, and laboratory data collected were analyzed using STATA11. Odds ratios (ORs) and 95% confidence intervals were determined using multivariable logistic regression with bootstrapping. There were 225/261 (86.2%) black/Africans, 31/261 (11.9%) Indian South Africans, 3/261 (1.1%) Caucasians, and 2/261 (<1%) mixed ancestry South Africans. Mean age was 51.3 ± 14.5 years. Median (interquartile range) estimated glomerular filtration rate (eGFR) was 71 (38) mL/min/1.73 m 2 and 39.8% (104/261) of patients had CKD. Hyperuricemia prevalence was 43.7% (114/261) and increased from 16.7% in patients with eGFR ≥90 mL/min/1.73 m 2 to 74.2% with eGFR <30 mL/min/1.73 m 2 (P < 0.001). Gout prevalence was 5.4% (14/261), with equal distribution across eGFR categories (0.814). Factors independently associated with hyperuricemia were eGFR <90 [ORs 3.24 (1.15-9.14), 7.28 (2.26-23.49), and 7.88 (1.95-31.82) for eGFR 60-89.9, 30-60, and <30, respectively], albuminuria [2.32 (1.11-4.85)], and waist circumference [1.04 (1.01-1.06) per 1 cm increase]. In univariate and multivariable analysis, gout was positively associated with male gender and cardiovascular disease, while it was negatively associated with African ancestry, but none of these factors remained significant after bootstrapping; ORs 6.65 (0.64-69.24), 4.14 (0.61-28.07), and 0.18 (0.01-2.21), respectively. Hyperuricemia prevalence was high, with CKD and waist circumference being the strongest predictors. Gout was uncommon in black Africans. With population data lacking, screening high-risk individuals may provide insight into the burden of hyperuricemia and gout in South Africa.

  1. 45 CFR 261.61 - How must a State document a work-eligible individual's hours of participation?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... individual who is self-employed, the documentation must comport with standards set forth in the State's approved Work Verification Plan. Self-reporting by a participant without additional verification is not... case file. In accordance with § 261.62, a State must describe in its Work Verification Plan the...

  2. 40 CFR 267.202 - What special requirements must I meet for ignitable or reactive wastes?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... material no longer meets the definition of ignitable or reactive waste under § 261.21 or § 261.23 of this... requirements for the maintenance of protective distances between the waste management area and any public ways... for ignitable or reactive wastes? 267.202 Section 267.202 Protection of Environment ENVIRONMENTAL...

  3. 45 CFR 261.16 - Does the imposition of a penalty affect an individual's work requirement?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual Responsibility? § 261.16 Does the imposition of a penalty affect an individual's work requirement... 45 Public Welfare 2 2010-10-01 2010-10-01 false Does the imposition of a penalty affect an...

  4. 40 CFR 97.261 - EPA recordation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Transfers § 97.261 EPA recordation. (a) Within 5 business days (except as necessary to perform a transfer in perpetuity of CAIR SO2 allowances allocated to a CAIR SO2 unit or as provided in paragraph (b) of this section) of receiving a CAIR...

  5. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b) and...

  6. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b) and...

  7. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b) and...

  8. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b) and...

  9. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b) and...

  10. Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

    PubMed

    Höttecke, Nicole; Liebeck, Miriam; Baumann, Karlheinz; Schubenel, Robert; Winkler, Edith; Steiner, Harald; Schmidt, Boris

    2010-05-01

    CK1 and gamma-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit gamma-secretase activity. The question is: Does CK1 inhibition directly influence gamma-secretase activity? Therefore we analyzed the SAR of 15 analogues and their impact on gamma-secretase activity. The most active compounds were investigated on CK1delta activity. These findings exclude a direct influence of CK1delta on gamma-secretase, because any change in the substitution pattern of IC261 diminished CK1 inhibition, whereas gamma-secretase inhibition is still exerted by several analogues. 2010 Elsevier Ltd. All rights reserved.

  11. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  12. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  13. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  14. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  15. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  16. 45 CFR 261.60 - What hours of participation may a State report for a work-eligible individual?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Participation Information? § 261.60 What hours of participation may a State report for a work-eligible... calculating the work participation rates for a month, actual hours may include the hours for which an... participation for up to six months based on current, documented actual hours of work. Any time a State receives...

  17. 45 CFR 261.60 - What hours of participation may a State report for a work-eligible individual?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... days that it wishes to count as holidays for those in unpaid activities in its Work Verification Plan... policies and definitions as part of its Work Verification Plan, specified at § 261.62. (c) For unsubsidized... toward the participation rate for a self-employed individual than the number derived by dividing the...

  18. 40 CFR Appendix Vi to Part 268 - Recommended Technologies To Achieve Deactivation of Characteristics in Section 268.42

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../subcategory Nonwastewaters Wastewaters D001 Ignitable Liquids based on 261.21(a)(1)—Low TOC Nonwastewater Subcategory (containing 1% to TOC) RORGSINCIN WETOX CHOXD BIODG n.a. D001 Ignitable Liquids based on 261.21(a)(1)—Ignitable Wastewater Subcategory (containing TOC) n.a. RORGSINCIN WETOX CHOXD BIODG D001...

  19. 45 CFR 261.80 - How do existing welfare reform waivers affect a State's penalty liability under this part?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK How Do Welfare Reform Waivers Affect State Penalties? § 261.80 How do existing welfare reform waivers affect a State's penalty... 45 Public Welfare 2 2010-10-01 2010-10-01 false How do existing welfare reform waivers affect a...

  20. 45 CFR 261.36 - Do welfare reform waivers affect the calculation of a State's participation rates?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Work Activities and How Do They Count? § 261.36 Do welfare reform waivers affect the calculation of a State's participation rates... 45 Public Welfare 2 2010-10-01 2010-10-01 false Do welfare reform waivers affect the calculation...

  1. 40 CFR 261.31 - Hazardous wastes from non-specific sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....40, § 264.301 or § 265.301. For the purposes of this listing, motor vehicle manufacturing is defined... processing or recycling oil-bearing hazardous secondary materials excluded under § 261.4(a)(12)(i), if those... purposes of the F037 and F038 listings, oil/water/solids is defined as oil and/or water and/or solids. (2...

  2. 40 CFR 261.31 - Hazardous wastes from non-specific sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....40, § 264.301 or § 265.301. For the purposes of this listing, motor vehicle manufacturing is defined... processing or recycling oil-bearing hazardous secondary materials excluded under § 261.4(a)(12)(i), if those... purposes of the F037 and F038 listings, oil/water/solids is defined as oil and/or water and/or solids. (2...

  3. High-performance software-only H.261 video compression on PC

    NASA Astrophysics Data System (ADS)

    Kasperovich, Leonid

    1996-03-01

    This paper describes an implementation of a software H.261 codec for PC, that takes an advantage of the fast computational algorithms for DCT-based video compression, which have been presented by the author at the February's 1995 SPIE/IS&T meeting. The motivation for developing the H.261 prototype system is to demonstrate a feasibility of real time software- only videoconferencing solution to operate across a wide range of network bandwidth, frame rate, and resolution of the input video. As the bandwidths of current network technology will be increased, the higher frame rate and resolution of video to be transmitted is allowed, that requires, in turn, a software codec to be able to compress pictures of CIF (352 X 288) resolution at up to 30 frame/sec. Running on Pentium 133 MHz PC the codec presented is capable to compress video in CIF format at 21 - 23 frame/sec. This result is comparable to the known hardware-based H.261 solutions, but it doesn't require any specific hardware. The methods to achieve high performance, the program optimization technique for Pentium microprocessor along with the performance profile, showing the actual contribution of the different encoding/decoding stages to the overall computational process, are presented.

  4. X-ray Source Populations in Old Open Clusters - Collinder 261

    NASA Astrophysics Data System (ADS)

    Vats, Smriti

    2014-11-01

    We are carrying out an X-ray survey of old open clusters (OCs) with the Chandra X-ray Observatory. Single old stars emit very faint X-rays, making X-rays produced by mass transfer in CVs, or by rapid rotation of the stars in tidally-locked, detached binaries detectable, without contamination from single stars. By comparing properties of interacting binaries in different environments, we aim to study binary evolution, and how dynamical encounters with other cluster members affect it. Collinder (Cr) 261 is an old OC(~7Gyr), with one of the richest populations inferred, of close binary populations and blue stragglers of all OCs. We will present the first results, detailing the X-ray population of Cr 261, in conjugation with other OCs, and in comparison with populations in globular clusters.

  5. 20 CFR 1002.261 - Who is responsible for funding any plan obligation to provide the employee with pension benefits?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Who is responsible for funding any plan... and Benefits Pension Plan Benefits § 1002.261 Who is responsible for funding any plan obligation to... rules discussed below, the employer is liable to the pension benefit plan to fund any obligation of the...

  6. 45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false How many hours must work-eligible individuals... What Are the Work Activities and How Do They Count? § 261.32 How many hours must work-eligible... a work experience or community service program for the maximum number of hours per month that a...

  7. 75 FR 20873 - 60-Day Notice of Proposed Information Collection: DS-2020 Retail Price Schedule, Part 3 and Part...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... Office: Bureau of Administration Office of Allowances (A/OPR/ALS). Form Number: DS-2020. Respondents... submissions): Office of Allowances (A/OPR/ALS), Room L314 SA-1, Department of State, Washington, DC 20522-0103 Fax: (202) 261-8707 or (202) 261-8708 Hand Delivery or Courier: Office of Allowances (A/OPR/ALS) Room...

  8. MHD generator electrode development. Summary report, July 1, 1981-September 30, 1982

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rossing, B.R.; Buckman, R.W. Jr.; Pouchot, W.D.

    Emphasis on this program was the development of and understanding wastage mechanism(s) of metallic electrodes which may be suitable alternatives to platinum anode material for use in long-term open cycle, coal-fired MHD generator operations. The laboratory tests simulate both modes of material wastage observed in MHD electrode operation; i.e., arc erosion (melting/vaporization) and electrochemical corrosion. Based on experimental results from the electrochemical tests at 1473/sup 0/K, the rank order listing of the materials tested for anode applications were platinum, E-Brite 26-1 modified with a five percent addition of platinum, chromium, IN 601, E-Brite 26-1, and 330 stainless steel ranked inmore » decreasing order. The rank order listing based on the arc erosion test was platinum, chromium, E-Brite 26-1, 330 stainless steel, and IN 601. The relative arc erosion resistance of materials based on the AVCO Mark VII generator test results gave a rank order of platinum, 330 stainless steel, IN 601, and E-Brite 26-1. Engineering tests under simulated open-cycle coal-fired MHD operating conditions were performed in the 500 kW Westinghouse Electrode System Test Facility (WESTF). Tests were conducted on candidate metallic anode materials (cold wall) and ceramic anode (hot wall) materials. A ten-hour duration cold wall slagging test was conducted on platinum, E-Brite 26-1, 330 stainless steel and IN 601 and the results were similar to those obtained for those materials in the AVCO Mark VII generator tests. Non-slagging, super hot (>1700/sup 0/C) wall hafnia-rare earth oxide electrodes were tested in a sulfurous, western coal-fired MHD environment. All four ceramic electrode pairs were destroyed. 20 references.« less

  9. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice.

    PubMed

    Zhang, Leying; Alizadeh, Darya; Van Handel, Michelle; Kortylewski, Marcin; Yu, Hua; Badie, Behnam

    2009-10-01

    As the main effector-cell population of the central nervous system, microglia (MG) are considered to play an important immunoregulatory function in a number of pathological conditions such as inflammation, trauma, degenerative disease, and brain tumors. Recent studies, however, have suggested that the anti-neoplastic function of MG may be suppressed in malignant brain tumors. Considering the proposed suppressive role of signal transducers and activators of transcription 3 (Stat3) in antitumor immunity, we evaluated the role of Stat3 inhibition on MG and macrophage (MP) activation and tumor growth in a murine glioma model. N9 MG cells were exposed to GL261 glioma conditioned medium (GL261-CM) and evaluated for Stat3 activity and cytokine expression. Furthermore, the role of Stat3 inhibition on MG and MP activation was studied both in vitro and in vivo. Finally, the effect of Stat3 inhibition on tumor growth was assessed in intracranial GL261 gliomas. GL261-CM increased Stat3 activity in N9 cells in vitro and resulted in overexpression of IL-10 and IL-6, and downregulation of IL1-beta, a pro-inflammatory cytokine. Inhibition of Stat3 by CPA-7 or siRNA reversed glioma-induced cytokine expression profile in N9 cells. Furthermore, inactivation of Stat3 in intracranial GL261 tumors by siRNA resulted in MG/MP activation and tumor growth inhibition. Glioma-induced MG and MP suppression may be mediated thorough Stat3. Inhibition of Stat3 function in tumor MG/MP may result in their activation and can potentially be used as an adjunct immunotherapy approach for gliomas.

  10. Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design.

    PubMed

    Xu, Li; Liu, Xiaohong; Yin, Zhenhao; Liu, Qian; Lu, Lili; Xiao, Min

    2016-12-01

    The α-L-rhamnosidase catalyzes the hydrolytic release of rhamnose from polysaccharides and glycosides and is widely used due to its applications in a variety of industrial processes. Our previous work reported that a wild-type α-L-rhamnosidase (RhaL1) from Alternaria sp. L1 could synthesize rhamnose-containing chemicals (RCCs) though reverse hydrolysis reaction with inexpensive rhamnose as glycosyl donor. To enhance the yield of reverse hydrolysis reaction and to determine the amino acid residues essential for the catalytic activity of RhaL1, site-directed mutagenesis of 11 residues was performed in this study. Through rationally designed mutations, the critical amino acid residues which may form direct or solvent-mediated hydrogen bonds with donor rhamnose (Asp 252 , Asp 257 , Asp 264 , Glu 530 , Arg 548 , His 553 , and Trp 555 ) and may form the hydrophobic pocket in stabilizing donor (Trp 261 , Tyr 302 , Tyr 316 , and Trp 369 ) in active-site of RhaL1 were analyzed, and three positive mutants (W261Y, Y302F, and Y316F) with improved product yield stood out. From the three positive variants, mutant W261Y accelerated the reverse hydrolysis with a prominent increase (43.7 %) in relative yield compared to the wild-type enzyme. Based on the 3D structural modeling, we supposed that the improved yield of mutant W261Y is due to the adjustment of the spatial position of the putative catalytic acid residue Asp 257 . Mutant W261Y also exhibited a shift in the pH-activity profile in hydrolysis reaction, indicating that introducing of a polar residue in the active site cavity may affect the catalysis behavior of the enzyme.

  11. Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory

    PubMed Central

    Wu, Junjie; Waxman, David J

    2015-01-01

    Cancer chemotherapy using cytotoxic drugs can induce immunogenic tumor cell death; however, dosing regimens and schedules that enable single-agent chemotherapy to induce adaptive immune-dependent ablation of large, established tumors with activation of long-term immune memory have not been identified. Here, we investigate this issue in a syngeneic, implanted GL261 glioma model in immune-competent mice given cyclophosphamide on a 6-day repeating metronomic schedule. Two cycles of metronomic cyclophosphamide treatment induced sustained upregulation of tumor-associated CD8+ cytotoxic T lymphocyte (CTL) cells, natural killer (NK) cells, macrophages, and other immune cells. Expression of CTL- and NK–cell-shared effectors peaked on Day 6, and then declined by Day 9 after the second cyclophosphamide injection and correlated inversely with the expression of the regulatory T cell (Treg) marker Foxp3. Sustained tumor regression leading to tumor ablation was achieved after several cyclophosphamide treatment cycles. Tumor ablation required CD8+ T cells, as shown by immunodepletion studies, and was associated with immunity to re-challenge with GL261 glioma cells, but not B16-F10 melanoma or Lewis lung carcinoma cells. Rejection of GL261 tumor re-challenge was associated with elevated CTLs in blood and increased CTL infiltration in tumors, consistent with the induction of long-term, specific CD8+ T-cell anti-GL261 tumor memory. Co-depletion of CD8+ T cells and NK cells did not inhibit tumor regression beyond CD8+ T-cell depletion alone, suggesting that the metronomic cyclophosphamide-activated NK cells function via CD8a+ T cells. Taken together, these findings provide proof-of-concept that single-agent chemotherapy delivered on an optimized metronomic schedule can eradicate large, established tumors and induce long-term immune memory. PMID:26137402

  12. Three-dimensional simulations of cumulus congestus clouds on GATE day 261

    NASA Technical Reports Server (NTRS)

    Simpson, J.; Van Helvoirt, G.; Mccumber, M.

    1982-01-01

    Schlesinger's (1978) three-dimensional cumulus model is applied to showering congestus clouds on day 261 of GATE. Model results are compared with each other and with observations to analyze the effects of varying shear and altered sounding. Relationships between shear, mesovortices and dynamic entrainment are examined, as well as the model clouds' impact on the environment as a function of shear. The simulations appear to resemble reality in many important aspects. Altostratus layers observed on day 261 are found to be a by-product of convection in three-dimensional shear. Rapid erosion of cloud base to 3.6 km is related to the ambient thermal structure, with wind shear and initial perturbation playing a secondary role. Some of the apparent conflict regarding lateral versus cloud-top entrainment is clarified, as well as some factors governing convective downdraft structure and intensity.

  13. 1. Adorni (Cheng 1997a, Sawyer 1981a)

    Treesearch

    Sheauchi Cheng

    2004-01-01

    This established RNA is on the Six Rivers National Forest. It lies about 3 miles (5 km) N. of Weitchpec, Humboldt County, covering portions of sects. 25 and 26 T10N, R4E HBM (41°14'N., 123°41'W.), USGS Weitchpec quad (fig. 3). Ecological subsections – Gasquet Mountain Ultramafics (M261Ab) and Eastern Franciscan (M261Ba).

  14. Measurements of the weak UV absorptions of isoprene and acetone at 261-275 nm using cavity ringdown spectroscopy for evaluation of a potential portable ringdown breath analyzer.

    PubMed

    Sahay, Peeyush; Scherrer, Susan T; Wang, Chuji

    2013-06-26

    The weak absorption spectra of isoprene and acetone have been measured in the wavelength range of 261-275 nm using cavity ringdown spectroscopy. The measured absorption cross-sections of isoprene in the wavelength region of 261-266 nm range from 3.65 × 10⁻²¹ cm².molecule⁻¹ at 261 nm to 1.42 × 10⁻²¹ cm².molecule⁻¹ at 266 nm; these numbers are in good agreement with the values reported in the literature. In the longer wavelength range of 270-275 nm, however, where attractive applications using a single wavelength compact diode laser operating at 274 nm is located, isoprene has been reported in the literature to have no absorption (too weak to be detected). Small absorption cross-sections of isoprene in this longer wavelength region are measured using cavity ringdown spectroscopy for the first time in this work, i.e., 6.20 × 10⁻²³ cm².molecule⁻¹ at 275 nm. With the same experimental system, wavelength-dependent absorption cross-sections of acetone have also been measured. Theoretical detection limits of isoprene and comparisons of absorbance of isoprene, acetone, and healthy breath gas in this wavelength region are also discussed.

  15. Joint Operation Planning and Execution

    DTIC Science & Technology

    1992-03-01

    Review Force Cargo Category Record ............. 261 Review Cargo Details ........................... 262 Tailor Force Record...shown. Tailor Force Cargo, Figure 7.11, is displayed. 261 <Xmit> to accept the update as shown. Tailor Force Cargo, Figure 7.11, is displayed. To review...8217 ZARZS TUNSA P 4S IAP DI’J ENTER FFPN,NPINPF!N,LP/,NPA3E ,. 2,ENr. Figure 12.8 GEOFILE Display After reviewing Figure 12.8, navigate back to the GEOFILE

  16. 45 CFR 261.15 - Can a family be penalized if a parent refuses to work because he or she cannot find child care?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Provisions Addressing Individual Responsibility? § 261.15 Can a family be penalized if a parent refuses to... parent caring for a child under age six who has a demonstrated inability to obtain needed child care, as... 45 Public Welfare 2 2011-10-01 2011-10-01 false Can a family be penalized if a parent refuses to...

  17. 45 CFR 261.15 - Can a family be penalized if a parent refuses to work because he or she cannot find child care?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Provisions Addressing Individual Responsibility? § 261.15 Can a family be penalized if a parent refuses to... parent caring for a child under age six who has a demonstrated inability to obtain needed child care, as... 45 Public Welfare 2 2013-10-01 2012-10-01 true Can a family be penalized if a parent refuses to...

  18. 45 CFR 261.15 - Can a family be penalized if a parent refuses to work because he or she cannot find child care?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Provisions Addressing Individual Responsibility? § 261.15 Can a family be penalized if a parent refuses to... parent caring for a child under age six who has a demonstrated inability to obtain needed child care, as... 45 Public Welfare 2 2012-10-01 2012-10-01 false Can a family be penalized if a parent refuses to...

  19. 45 CFR 261.15 - Can a family be penalized if a parent refuses to work because he or she cannot find child care?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Provisions Addressing Individual Responsibility? § 261.15 Can a family be penalized if a parent refuses to... parent caring for a child under age six who has a demonstrated inability to obtain needed child care, as... 45 Public Welfare 2 2010-10-01 2010-10-01 false Can a family be penalized if a parent refuses to...

  20. 45 CFR 261.15 - Can a family be penalized if a parent refuses to work because he or she cannot find child care?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Provisions Addressing Individual Responsibility? § 261.15 Can a family be penalized if a parent refuses to... parent caring for a child under age six who has a demonstrated inability to obtain needed child care, as... 45 Public Welfare 2 2014-10-01 2012-10-01 true Can a family be penalized if a parent refuses to...

  1. Subgrain refinement strengthening. Second quarterly progress report, January 1, 1975-March 31, 1975. [Epsilon-Brite 26-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klundt, R.; Walser, B.; Monma, Y.

    During the past quarter (January-March 1975) we have initiated mechanical properties studies on type 304 stainless steel and on a ferritic alloy, E-Brite 26-1. Purpose of these studies was to establish a sound data base from which the alloys specifically chosen for this program can be evaluated (namely, ferritic steel, precipitation hardening austenitic stainless steel and a nickel rich austenitic alloy).

  2. 40 CFR 260.22 - Petitions to amend part 261 to exclude a waste produced at a particular facility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (c) If the waste is listed with codes “I”, “C”, “R”, or “E”, in subpart D, (1) The petitioner must... waste by operation of subpart C of part 261. (e) If the waste is listed with the code “H” in subpart D... a waste produced at a particular facility. 260.22 Section 260.22 Protection of Environment...

  3. 40 CFR 260.22 - Petitions to amend part 261 to exclude a waste produced at a particular facility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (c) If the waste is listed with codes “I”, “C”, “R”, or “E”, in subpart D, (1) The petitioner must... waste by operation of subpart C of part 261. (e) If the waste is listed with the code “H” in subpart D... a waste produced at a particular facility. 260.22 Section 260.22 Protection of Environment...

  4. 40 CFR 260.22 - Petitions to amend part 261 to exclude a waste produced at a particular facility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (c) If the waste is listed with codes “I”, “C”, “R”, or “E”, in subpart D, (1) The petitioner must... waste by operation of subpart C of part 261. (e) If the waste is listed with the code “H” in subpart D... a waste produced at a particular facility. 260.22 Section 260.22 Protection of Environment...

  5. 40 CFR 260.22 - Petitions to amend part 261 to exclude a waste produced at a particular facility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... (c) If the waste is listed with codes “I”, “C”, “R”, or “E”, in subpart D, (1) The petitioner must... waste by operation of subpart C of part 261. (e) If the waste is listed with the code “H” in subpart D... a waste produced at a particular facility. 260.22 Section 260.22 Protection of Environment...

  6. 78 FR 73109 - Radio Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and Shamrock, TX AGENCY... 237C3 at Benjamin, Texas; Channel 261C3 at Cisco, Texas; Channel 288C2 at Rule, Texas; and Channel 225C2..., Channel 237C3; by removing Cisco, Channel 261C3; by removing Channel 288C2 at Rule; and by removing...

  7. Measurements of the Weak UV Absorptions of Isoprene and Acetone at 261–275 nm Using Cavity Ringdown Spectroscopy for Evaluation of a Potential Portable Ringdown Breath Analyzer

    PubMed Central

    Sahay, Peeyush; Scherrer, Susan T.; Wang, Chuji

    2013-01-01

    The weak absorption spectra of isoprene and acetone have been measured in the wavelength range of 261–275 nm using cavity ringdown spectroscopy. The measured absorption cross-sections of isoprene in the wavelength region of 261–266 nm range from 3.65 × 10−21 cm2·molecule−1 at 261 nm to 1.42 × 10−21 cm2·molecule−1 at 266 nm; these numbers are in good agreement with the values reported in the literature. In the longer wavelength range of 270–275 nm, however, where attractive applications using a single wavelength compact diode laser operating at 274 nm is located, isoprene has been reported in the literature to have no absorption (too weak to be detected). Small absorption cross-sections of isoprene in this longer wavelength region are measured using cavity ringdown spectroscopy for the first time in this work, i.e., 6.20 × 10−23 cm2·molecule−1 at 275 nm. With the same experimental system, wavelength-dependent absorption cross-sections of acetone have also been measured. Theoretical detection limits of isoprene and comparisons of absorbance of isoprene, acetone, and healthy breath gas in this wavelength region are also discussed. PMID:23803787

  8. Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

    PubMed

    Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan; Jin, Chuan; Laaniste, Liisi; El Hassan, Tamador Elsir Abu; Ohlin, K Elisabet; Yu, Di; Olofsson, Tommie; Olsson, Anna-Karin; Pontén, Fredrik; Magnusson, Peetra U; Nilsson, Karin Forsberg; Essand, Magnus; Smits, Anja; Dieterich, Lothar C; Dimberg, Anna

    2015-12-08

    Glioblastomas are aggressive astrocytomas characterized by endothelial cell proliferation and abnormal vasculature, which can cause brain edema and increase patient morbidity. We identified the heparin-binding cytokine pleiotrophin as a driver of vascular abnormalization in glioma. Pleiotrophin abundance was greater in high-grade human astrocytomas and correlated with poor survival. Anaplastic lymphoma kinase (ALK), which is a receptor that is activated by pleiotrophin, was present in mural cells associated with abnormal vessels. Orthotopically implanted gliomas formed from GL261 cells that were engineered to produce pleiotrophin showed increased microvessel density and enhanced tumor growth compared with gliomas formed from control GL261 cells. The survival of mice with pleiotrophin-producing gliomas was shorter than that of mice with gliomas that did not produce pleiotrophin. Vessels in pleiotrophin-producing gliomas were poorly perfused and abnormal, a phenotype that was associated with increased deposition of vascular endothelial growth factor (VEGF) in direct proximity to the vasculature. The growth of pleiotrophin-producing GL261 gliomas was inhibited by treatment with the ALK inhibitor crizotinib, the ALK inhibitor ceritinib, or the VEGF receptor inhibitor cediranib, whereas control GL261 tumors did not respond to either inhibitor. Our findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization. Copyright © 2015, American Association for the Advancement of Science.

  9. Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme.

    PubMed

    Abbadi, A; Brummel, M; Schütt, B S; Slabaugh, M B; Schuch, R; Spener, F

    2000-01-01

    A unique feature of fatty acid synthase (FAS) type II of higher plants and bacteria is 3-oxoacyl-[acyl-carrier-protein (ACP)] synthase III (KAS III), which catalyses the committing condensing reaction. Working with KAS IIIs from Cuphea seeds we obtained kinetic evidence that KAS III catalysis follows a Ping-Pong mechanism and that these enzymes have substrate-binding sites for acetyl-CoA and malonyl-ACP. It was the aim of the present study to identify these binding sites and to elucidate the catalytic mechanism of recombinant Cuphea wrightii KAS III, which we expressed in Escherichia coli. We engineered mutants, which allowed us to dissect the condensing reaction into three stages, i.e. formation of acyl-enzyme, decarboxylation of malonyl-ACP, and final Claisen condensation. Incubation of recombinant enzyme with [1-(14)C]acetyl-CoA-labelled Cys(111), and the replacement of this residue by Ala and Ser resulted in loss of overall condensing activity. The Cys(111)Ser mutant, however, still was able to bind acetyl-CoA and to catalyse subsequent binding and decarboxylation of malonyl-ACP to acetyl-ACP. We replaced His(261) with Ala and Arg and found that the former lost activity, whereas the latter retained overall condensing activity, which indicated a general-base action of His(261). Double mutants Cys(111)Ser/His(261)Ala and Cys(111)Ser/His(261)Arg were not able to catalyse overall condensation, but the double mutant containing Arg induced decarboxylation of [2-(14)C]malonyl-ACP, a reaction indicating the role of His(261) in general-acid catalysis. Finally, alanine scanning revealed the involvement of Arg(150) and Arg(306) in KAS III catalysis. The results offer for the first time a detailed mechanism for a condensing reaction catalysed by a FAS type II condensing enzyme.

  10. Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme.

    PubMed Central

    Abbadi, A; Brummel, M; Schütt, B S; Slabaugh, M B; Schuch, R; Spener, F

    2000-01-01

    A unique feature of fatty acid synthase (FAS) type II of higher plants and bacteria is 3-oxoacyl-[acyl-carrier-protein (ACP)] synthase III (KAS III), which catalyses the committing condensing reaction. Working with KAS IIIs from Cuphea seeds we obtained kinetic evidence that KAS III catalysis follows a Ping-Pong mechanism and that these enzymes have substrate-binding sites for acetyl-CoA and malonyl-ACP. It was the aim of the present study to identify these binding sites and to elucidate the catalytic mechanism of recombinant Cuphea wrightii KAS III, which we expressed in Escherichia coli. We engineered mutants, which allowed us to dissect the condensing reaction into three stages, i.e. formation of acyl-enzyme, decarboxylation of malonyl-ACP, and final Claisen condensation. Incubation of recombinant enzyme with [1-(14)C]acetyl-CoA-labelled Cys(111), and the replacement of this residue by Ala and Ser resulted in loss of overall condensing activity. The Cys(111)Ser mutant, however, still was able to bind acetyl-CoA and to catalyse subsequent binding and decarboxylation of malonyl-ACP to acetyl-ACP. We replaced His(261) with Ala and Arg and found that the former lost activity, whereas the latter retained overall condensing activity, which indicated a general-base action of His(261). Double mutants Cys(111)Ser/His(261)Ala and Cys(111)Ser/His(261)Arg were not able to catalyse overall condensation, but the double mutant containing Arg induced decarboxylation of [2-(14)C]malonyl-ACP, a reaction indicating the role of His(261) in general-acid catalysis. Finally, alanine scanning revealed the involvement of Arg(150) and Arg(306) in KAS III catalysis. The results offer for the first time a detailed mechanism for a condensing reaction catalysed by a FAS type II condensing enzyme. PMID:10600651

  11. FLO/FLO Sea Basing Concept Ship Model Testing

    DTIC Science & Technology

    2006-08-01

    ππ rollf ff rollsys syssysT T ZW T ZWI (4) 7 Naval Surface Warfare Center Carderock...ff pitchsys syssysL T ZW T ZWI (5) The final moments were calculated by shifting the above results to the model...Test 8-water up 28" 5-side,5-back 0 seakeeping 280 2 off 4 2.61 Test 9-water up 30" 5-side,5-back 0 seakeeping 281 2 off 4 2.61 Test 10-same 5-side

  12. Joint Services Electronics Program of the Edward L. Ginzton Laboratory of Stanford University.

    DTIC Science & Technology

    1980-04-01

    Differential Holography of Irregular Phase Objects Using Phase Conjugate Reflection," Optics Commun. 31, 257-258 (December 1979). R.A. Bergh, G. Kotler , and...values at the outer diameter of 3 5 R. A. Bergh, G. Kotler , and H. J. Shaw, Electronics Letters 16, 7, 260-261 (21 March 1980). -33 - the cladding. Thus...and signal processing techniques. E. Publications under JSEP Program R.A. Bergh, G. Kotler , and H.J. Shaw, Electronics Letters 16, 260-261 (21 March

  13. On implicit abstract neutral nonlinear differential equations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hernández, Eduardo, E-mail: lalohm@ffclrp.usp.br; O’Regan, Donal, E-mail: donal.oregan@nuigalway.ie

    2016-04-15

    In this paper we continue our developments in Hernández and O’Regan (J Funct Anal 261:3457–3481, 2011) on the existence of solutions for abstract neutral differential equations. In particular we extend the results in Hernández and O’Regan (J Funct Anal 261:3457–3481, 2011) for the case of implicit nonlinear neutral equations and we focus on applications to partial “nonlinear” neutral differential equations. Some applications involving partial neutral differential equations are presented.

  14. Odd-Z Transactinide Compound Nucleus Reactions Including the Discovery of 260Bh

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, Sarah L.

    Several reactions producing odd-Z transactinide compound nuclei were studiedwith the 88-Inch Cyclotron and the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory. The goal was to produce the same compound nucleus ator near the same excitation energy with similar values of angular momentum via differentnuclear reactions. In doing so, it can be determined if there is a preference in entrancechannel, because under these experimental conditions the survival portion of Swiatecki, Siwek-Wilcznska, and Wilczynski's"Fusion By Diffusion" model is nearly identical forthe two reactions. Additionally, because the same compound nucleus is produced, theexit channel is the same. Four compound nuclei were examined in this study: 258Db, 262Bh, 266Mt, and 272Rg. These nuclei were produced by using very similar heavy-ion induced-fusion reactions which differ only by one proton in the projectile or target nucleus (e.g.: 50Ti + 209Bi vs. 51V + 208Pb). Peak 1n exit channel cross sections were determined for each reaction in each pair, and three of the four pairs' cross sections were identical within statistical uncertainties. This indicates there is not an obvious preference of entrancechannel in these paired reactions. Charge equilibration immediately prior to fusionleading to a decreased fusion barrier is the likely cause of this phenomenon. In addition to this systematic study, the lightest isotope of element 107, bohrium, was discovered in the 209Bi( 52Cr,n) reaction. 260Bh was found to decay by emission of a 10.16 MeV alpha particle with a half-life of 35more » $$+19\\atop{-9}$$ ms. The cross section is 59 pb at an excitation energy of 15.0 MeV. The effect of the N = 152 shell is also seen in this isotope's alpha particle energy, the first evidence of such an effect in Bh. All reactions studied are also compared to model predictions by Swiatecki, Siwek-Wilcznska, and Wilczynski 's" Fusion By Diffusion " theory.« less

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ono, Kenji; Fuma, Kazuya; Tabata, Kaori

    Magnetic resonance imaging (MRI) is a minimally invasive way to provide high spatial resolution tomograms. However, MRI has been considered to be useless for gene expression imaging compared to optical imaging. In this study, we used a ferritin reporter, binding with biogenic iron, to make it a powerful tool for gene expression imaging in MRI studies. GL261 mouse glioma cells were over-expressed with dual-reporter ferritin-DsRed under {beta}-actin promoter, then gene expression was observed by optical imaging and MRI in a brain tumor model. GL261 cells expressing ferritin-DsRed fusion protein showed enhanced visualizing effect by reducing T2-weighted signal intensity for inmore » vitro and in vivo MRI studies, as well as DsRed fluorescence for optical imaging. Furthermore, a higher contrast was achieved on T2-weighted images when permeating the plasma membrane of ferritin-DsRed-expressing GL261. Thus, a ferritin expression vector can be used as an MRI reporter to monitor in vivo gene expression.« less

  16. Superheavy element chemistry at GARIS

    NASA Astrophysics Data System (ADS)

    Haba, Hiromitsu

    2016-12-01

    A gas-jet transport system has been installed to the RIKEN GAs-filled Recoil Ion Separator, GARIS to start up SuperHeavy Element (SHE) chemistry. This system is a promising approach for exploring new frontiers in SHE chemistry: background radioactivities from unwanted by-products are suppressed, a high gas-jet transport yield is achieved, and new chemical reactions can be investigated. Useful radioisotopes of 261Rfa,b, 262Db, and 265Sga,b for chemical studies were produced in the reactions of 248Cm(18O,5n)261Rfa,b, 248Cm(19F,5n)262Db, and 248Cm(22Ne,5n)265Sga,b, respectively. They were successfully extracted to a chemistry laboratory by the gas-jet method. Production and decay properties of 261Rfa,b, 262Db, and 265Sga,b were investigated in detail with the rotating wheel apparatus for α- and spontaneous fission spectrometry. Present status and perspectives of the SHE chemistry at GARIS are also briefly presented.

  17. Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas

    PubMed Central

    Feldman, Lisa A.; Fabre, Marie-Sophie; Grasso, Carole; Reid, Dana; Broaddus, William C.; Lanza, Gregory M.; Spiess, Bruce D.; Garbow, Joel R.; McConnell, Melanie J.

    2017-01-01

    Background Tumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy. Aim To investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice breathing carbogen (95%O2 and 5%CO2). Results PFC emulsions completely abrogated hypoxia in both subcutaneous and intracranial GL261 models and conferred a significant survival advantage orthotopically (Mantel Cox: p = 0.048) in carbogen breathing mice injected intravenously (IV) with PFC emulsions before radiation versus mice receiving radiation alone. Carbogen alone decreased hypoxia levels substantially and conferred a smaller but not statistically significant survival advantage over and above radiation alone. Conclusion IV injections of PFC emulsions followed by 1h carbogen breathing, radiosensitises GL261 intracranial tumors. PMID:28873460

  18. Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction.

    PubMed

    Resende, Fernando F B; Bai, Xianshu; Del Bel, Elaine Aparecida; Kirchhoff, Frank; Scheller, Anja; Titze-de-Almeida, Ricardo

    2016-02-08

    Glioblastoma multiforme is the most aggressive brain tumor. Microglia are prominent cells within glioma tissue and play important roles in tumor biology. This work presents an animal model designed for the study of microglial cell morphology in situ during gliomagenesis. It also allows a quantitative morphometrical analysis of microglial cells during their activation by glioma cells. The animal model associates the following cell types: 1- mCherry red fluorescent GL261 glioma cells and; 2- EGFP fluorescent microglia, present in the TgH(CX3CR1-EGFP) mouse line. First, mCherry-GL261 glioma cells were implanted in the brain cortex of TgH(CX3CR1-EGFP) mice. Epifluorescence - and confocal laser-scanning microscopy were employed for analysis of fixed tissue sections, whereas two-photon laser-scanning microscopy (2P-LSM) was used to track tumor cells and microglia in the brain of living animals. Implanted mCherry-GL261 cells successfully developed brain tumors. They mimic the aggressive behavior found in human disease, with a rapid increase in size and the presence of secondary tumors apart from the injection site. As tumor grows, mCherry-GL261 cells progressively lost their original shape, adopting a heterogeneous and diffuse morphology at 14-18 d. Soma size increased from 10-52 μm. At this point, we focused on the kinetics of microglial access to glioma tissues. 2P-LSM revealed an intense microgliosis in brain areas already shortly after tumor implantation, i.e. at 30 min. By confocal microscopy, we found clusters of microglial cells around the tumor mass in the first 3 days. Then cells infiltrated the tumor area, where they remained during all the time points studied, from 6-18 days. Microglia in contact with glioma cells also present changes in cell morphology, from a ramified to an amoeboid shape. Cell bodies enlarged from 366 ± 0.0 μm(2), in quiescent microglia, to 1310 ± 146.0 μm(2), and the cell processes became shortened. The GL261/CX3CR1 mouse model reported here is a valuable tool for imaging of microglial cells during glioma growth, either in fixed tissue sections or living animals. Remarkable advantages are the use of immunocompetent animals and the simplified imaging method without the need of immunohistochemical procedures.

  19. SFD-261 Crossed-Field Amplifier Manufacturing Technology Program.

    DTIC Science & Technology

    1979-09-28

    microwave amplifier used to increase tet pow--rlel of pulses of energy by a factor of 20. It is used in the Aegis A4/SPY1V DD 1473 ECIIOwOF I MOV 65...transmitter. A single ship.,; complement without spares is seventy-six. Its internal parts are made from high purity copper and many are complex and...23 Cathode Support 39 24 Mounting Plate ’i 25 Support Plate 42 26 Tubing Support 43 27 SFD-261 High Voltage Can End 45 b 28 Comparison of MT Tube

  20. Reversible intermolecular energy transfer between saturated amines and benzene in non-polar solution

    NASA Astrophysics Data System (ADS)

    Halpern, Arthur M.; Wryzykowska, Krystyna

    1981-01-01

    Excitation of a mixture of dimethylethylamine (DEMA) and benzene in n-hexane at 222 nm primarily produces excited amine, while at 261 nm excited benzene predominantly results. The fluorescence spectra appreciably overlap. With 222 nm excitation, DEMA fluorescence is quenched by benzene at the diffusion-controlled rate; this quenching results with nearly unit efficiency in sensitized benzene fluorescence. With 261 nm excitation, some sensitized DEMA fluorescence is observed: the rate constant for tins process is ≈ 2.6 × 10 9 M -1 s -1.

  1. Sequence analysis and heterologous expression of the wool cuticle-degrading enzyme encoding genes in Fusarium oxysporum 26-1.

    PubMed

    Chaya, Etsushi; Suzuki, Tohru; Karita, Shuichi; Hanya, Akira; Yoshino-Yasuda, Shoko; Kitamoto, Noriyuki

    2014-06-01

    Two protease-like proteins, KrtA and KrtC, were identified in Fusarium oxysporum 26-1. Genes coding these proteins, krtA and krtC, were isolated and characterized. Recombinant KrtA (rKrtA) and KrtC (rKrtC) were successfully expressed in Aspergillus oryzae and secreted. The combination of rKrtA and rKrtC completely removed the cuticle of wool fibers. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  2. Feasibility Study and Development of Modular Appliance Technologies, Centralized Heating (MATCH) Field Kitchen

    DTIC Science & Technology

    1994-07-01

    including standby losses. The required input fuel rate is 261.000 Btu/hr ( LHV ) or 277,700 Btu/hr ( HHV ). The Becker burner used in the system is rated at 2...cost of -$6/gallon. Burning diesel fuel , with 20-percent excess air and a final exhaust temperature of 932°F, requires a fuel LHV input of 261,000 Btu...GPH diesel fuel burning rate, corresponding to 280.000 Btu/hr ( HHV ) input. The flue gases leave the fluid heater at a nominal temperature of 932°F

  3. The 1985 ARI Survey of Army Recruits: Tabular Description of NPS (active) Army Accessions. Volume 1

    DTIC Science & Technology

    1987-04-01

    T261 -- WATCH TV PROG:NBA BASKETBALL DO YOU WATCH ANY OF THE FOLLOWING PROGRAMS OR PROGRAMMING TYPES ON REGULAR TV STATIONS? .- NBA BASKETBALL . 1...327𔃻 261 WATCH TV PROG:NBA BASKETBALL 328-329 T262 WATCH TV PROG:COLLEGE BASKETBALL 330-331 T263 WATCH TV PROG:NHL HOCKEY 332-333 T264 WlATCH TV...T262 -- WATCH TV PROG:COLLEGE BASKETBALL DO YOU WATCH ANY OF THE FOLLOWING PROGRAMS OR PROGRAMMING TYPES ON REGULAR TV STATIONS? - COLLEGE BASKETBALL . 1

  4. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model.

    PubMed

    Towner, Rheal A; Ihnat, Michael; Saunders, Debra; Bastian, Anja; Smith, Nataliya; Pavana, Roheeth Kumar; Gangjee, Aleem

    2015-07-17

    High grade gliomas (HGGs; grades III and IV) are the most common primary brain tumors in adults, and their malignant nature ranks them fourth in incidence of cancer death. Standard treatment for glioblastomas (GBM), involving surgical resection followed by radiation and chemotherapy with temozolomide (TMZ) and the anti-angiogenic therapy bevacizumab, have not substantially improved overall survival. New therapeutic agents are desperately needed for this devastating disease. Here we study the potential therapeutic agent AG119 in a pre-clinical model for gliomas. AG119 possesses both anti-angiogenic (RTK inhibition) and antimicrotubule cytotoxic activity in a single molecule. GL261 glioma-bearing mice were either treated with AG119, anti-VEGF (vascular endothelial growth factor) antibody, anti c-Met antibody or TMZ, and compared to untreated tumor-bearing mice. Animal survival was assessed, and tumor volumes and vascular alterations were monitored with morphological magnetic resonance imaging (MRI) and perfusion-weighted imaging, respectively. Percent survival of GL261 HGG-bearing mice treated with AG119 was significantly higher (p < 0.001) compared to untreated tumors. Tumor volumes (21-31 days following intracerebral implantation of GL261 cells) were found to be significantly lower for AG119 (p < 0.001), anti-VEGF (p < 0.05) and anti-c-Met (p < 0.001) antibody treatments, and TMZ-treated (p < 0.05) mice, compared to untreated controls. Perfusion data indicated that both AG119 and TMZ were able to reduce the effect of decreasing perfusion rates significantly (p < 0.05 for both), when compared to untreated tumors. It was also found that IC50 values for AG119 were much lower than those for TMZ in T98G and U251 cells. These data support further exploration of the anticancer activity AG119 in HGG, as this compound was able to increase animal survival and decrease tumor volumes in a mouse GL261 glioma model, and that AG119 is also not subject to methyl guanine transferase (MGMT) mediated resistance, as is the case with TMZ, indicating that AG119 may be potentially useful in treating resistant gliomas.

  5. Closure Report for Corrective Action Unit 261: Area 25 Test Cell A Leachfield System, Nevada Test Site, Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    T. M. Fitzmaurice

    2001-04-01

    The purpose of this Closure Report (CR) is to provide documentation of the completed corrective action at the Test Cell A Leachfield System and to provide data confirming the corrective action. The Test Cell A Leachfield System is identified in the Federal Facility Agreement and Consent Order (FFACO) of 1996 as Corrective Action Unit (CAU) 261. Remediation of CAU 261 is required under the FFACO (1996). CAU 261 is located in Area 25 of the Nevada Test Site (NTS) which is approximately 140 kilometers (87 miles) northwest of Las Vegas, Nevada (Figure 1). CAU 261 consists of two Corrective Actionmore » Sites (CASS): CAS 25-05-01, Leachfield; and CAS 25-05-07, Acid Waste Leach Pit (AWLP) (Figures 2 and 3). Test Cell A was operated during the 1960s and 1970s to support the Nuclear Rocket Development Station. Various operations within Building 3124 at Test Cell A resulted in liquid waste releases to the Leachfield and the AWLP. The following existing site conditions were reported in the Corrective Action Decision Document (CADD) (U.S. Department of Energy, Nevada Operations Office [DOE/NV], 1999): Soil in the leachfield was found to exceed the Nevada Division of Environmental Protection (NDEP) Action Level for petroleum hydrocarbons, the U.S. Environmental Protection Agency (EPA) preliminary remediation goals for semi volatile organic compounds, and background concentrations for strontium-90; Soil below the sewer pipe and approximately 4.5 meters (m) (15 feet [ft]) downstream of the initial outfall was found to exceed background concentrations for cesium-137 and strontium-90; Sludge in the leachfield septic tank was found to exceed the NDEP Action Level for petroleum hydrocarbons and to contain americium-241, cesium-137, uranium-234, uranium-238, potassium-40, and strontium-90; No constituents of concern (COC) were identified at the AWLP. The NDEP-approved CADD (DOWNV, 1999) recommended Corrective Action Alternative 2, ''Closure of the Septic Tank and Distribution Box, Partial Excavation, and Administrative Controls.'' The corrective action was performed following the NDEP-approved Corrective Action Plan (CAP) (DOE/NV, 2000).« less

  6. DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma

    PubMed Central

    Maes, Wim; Rosas, Georgina Galicia; Verbinnen, Bert; Boon, Louis; De Vleeschouwer, Steven; Ceuppens, Jan L.; Van Gool, Stefaan W.

    2009-01-01

    We studied the feasibility, efficacy, and mechanisms of dendritic cell (DC) immunotherapy against murine malignant glioma in the experimental GL261 intracranial (IC) tumor model. When administered prophylactically, mature DCs (DCm) ex vivo loaded with GL261 RNA (DCm-GL261-RNA) protected half of the vaccinated mice against IC glioma, whereas treatment with mock-loaded DCm or DCm loaded with irrelevant antigens did not result in tumor protection. In DCm-GL261-RNA–vaccinated mice, a tumor-specific cellular immune response was observed ex vivo in the spleen and tumor-draining lymph node cells. Specificity was also shown in vivo on the level of tumor challenge. Depletion of CD8+ T-cells by anti-CD8 treatment at the time of tumor challenge demonstrated their essential role in vaccine- mediated antitumor immunity. Depletion of CD25+ regulatory T-cells (Tregs) by anti-CD25 (aCD25) treatment strongly enhanced the efficacy of DC vaccination and was itself also protective, independently of DC vaccination. However, DC vaccination was essential to protect the animals from IC tumor rechallenge. No long-term protection was observed in animals that initially received aCD25 treatment only. In mice that received DC and/or aCD25 treatment, we retrieved tumor-specific brain-infiltrating cytotoxic T-lymphocytes. These data clearly demonstrate the effectiveness of DC vaccination for the induction of long-lasting immunological protection against IC glioma. They also show the beneficial effect of Treg depletion in this kind of glioma immunotherapy, even combined with DC vaccination. PMID:19336528

  7. Two successive magneto-structural transformations and their relation to enhanced magnetocaloric effect for Ni55.8Mn18.1Ga26.1 Heusler alloy

    PubMed Central

    Li, Zhe; Xu, Kun; Zhang, Yuanlei; Tao, Chang; Zheng, Dong; Jing, Chao

    2015-01-01

    In the present work, two successive magneto-structural transformations (MSTs) consisting of martensitic and intermartensitic transitions have been observed in polycrystalline Ni55.8Mn18.1Ga26.1 Heusler alloy. Benefiting from the additional latent heat contributed from intermediate phase, this alloy exhibits a large transition entropy change ΔStr with the value of ~27 J/kg K. Moreover, the magnetocaloric effect (MCE) has been also evaluated in terms of Maxwell relation. For a magnetic field change of 30 kOe, it was found that the calculated value of refrigeration capacity in Ni55.8Mn18.1Ga26.1 attains to ~72 J/kg around room temperature, which significantly surpasses those obtained for many Ni-Mn based Heusler alloys in the same condition. Such an enhanced MCE can be ascribed to the fact that the isothermal entropy change ΔST is spread over a relatively wide temperature interval owing to existence of two successive MSTs for studied sample. PMID:26450663

  8. Cysteine 295 indirectly affects Ni coordination of carbon monoxide dehydrogenase-II C-cluster

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Inoue, Takahiro; Takao, Kyosuke; Yoshida, Takashi

    2013-11-08

    Highlights: •CODH-II harbors a unique [Ni-Fe-S] cluster. •We substituted the ligand residues of Cys{sup 295} and His{sup 261}. •Dramatic decreases in Ni content upon substitutions were observed. •All substitutions did not affect Fe-S clusters assembly. •CO oxidation activity was decreased by the substitutions. -- Abstract: A unique [Ni–Fe–S] cluster (C-cluster) constitutes the active center of Ni-containing carbon monoxide dehydrogenases (CODHs). His{sup 261}, which coordinates one of the Fe atoms with Cys{sup 295}, is suggested to be the only residue required for Ni coordination in the C-cluster. To evaluate the role of Cys{sup 295}, we constructed CODH-II variants. Ala substitution formore » the Cys{sup 295} substitution resulted in the decrease of Ni content and didn’t result in major change of Fe content. In addition, the substitution had no effect on the ability to assemble a full complement of [Fe–S] clusters. This strongly suggests Cys{sup 295} indirectly and His{sup 261} together affect Ni-coordination in the C-cluster.« less

  9. Survey of Current Business. Volume 71, Number 10, October 1991

    DTIC Science & Technology

    1991-10-01

    3730 400.9 397-5 404.5 411.2 417.8 4238 429.1 State and local .. .............. 2570 261 261.7 262.7 2636 2,%4 264.9 2651 Rest of the world ...37.6 41.7 31.6 42.9 50.8 4.8 43.6 42.4 Rest of the world ....... . 30.2 31.9 24.5 32. 38.2 40.5 32.0 31.0 Addendum: Addendum: Gros domestic...government, and rust of the world , and includes asimali amount of final saes by fartms. rates 2 QuarterY tot as mronthly rates. Blusness finail sales

  10. An Extreme, Blueshifted Iron Line in the Narrow Line Seyfert 1 PG 1402+261

    NASA Technical Reports Server (NTRS)

    Reeves, J. N.; Porquet, D.; Turner, T. J.

    2004-01-01

    We report on a short, XMM-Newton observation of the radio-quiet Narrow Line Seyfert 1 PG 1402+261. The EPIC X-ray spectrum of PG 1402+261 shows a strong excess of counts between 6 - 9 keV in the rest frame. This feature can be modeled by an unusually strong (equivalent width 2 keV) and very broad energy at 7.3 keV appears blue-shifted with respect to the iron Kalpha emission band between 6.4 - 6.97 keV, whilst the blue-wing of the line extends to 9 keV in the quasar rest frame. The line profile can be fitted by reflection from the inner accretion disk, but an inclination angle of greater than 60 degrees is required to model the extreme blue-wing of the line. Furthermore the extreme strength of the line requires a geometry whereby the hard X-ray emission from PG1402+261 above 2 keV is dominated by the pure-reflection component from the disk, whilst little or none of the direct hard power-law is observed. Alternatively the spectrum above 2 keV may instead be explained by an ionized absorber, if the column density is sufficiently high (NH greater than 3 x 10(exp 23) per square centimeter) and if the matter is ionized enough to produce a deep (tau approximately equal to 1) iron K-shell absorption edge at 9 keV. This absorber could originate in a large column density, high velocity outflow, perhaps similar to those which appear to be observed in several other high accretion rate AGN. Further observations, especially at higher spectral resolution, are required to distinguish between the accretion disk reflection or outflow scenarios.

  11. Listed waste determination report. Environmental characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-06-01

    On September 23, 1988, the US Environmental Protection Agency (EPA) published a notice clarifying interim status requirements for the management of radioactive mixed waste thereby subjecting the Idaho National Engineering Laboratory (INEL) and other applicable Department of Energy (DOE) sites to regulation under the Resource Conservation and Recovery Act (RCRA). Therefore, the DOE was required to submit a Part A Permit application for each treatment, storage, and disposal (TSD) unit within the INEL, defining the waste codes and processes to be regulated under RCRA. The September 1990 revised Part A Permit application, that was approved by the State of Idahomore » identified 101 potential acute and toxic hazardous waste codes (F-, P-, and U- listed wastes according to 40 CFR 261.31 and 40 CFR 261.33) for some TSD units at the Idaho Chemical Processing Plant. Most of these waste were assumed to have been introduced into the High-level Liquid Waste TSD units via laboratory drains connected to the Process Equipment Waste (PEW) evaporator (PEW system). At that time, a detailed and systematic evaluation of hazardous chemical use and disposal practices had not been conducted to determine if F-, P-, or Unlisted waste had been disposed to the PEW system. The purpose of this investigation was to perform a systematic and detailed evaluation of the use and disposal of the 101 F-, P-, and Unlisted chemicals found in the approved September 1990 Part A Permit application. This investigation was aimed at determining which listed wastes, as defined in 40 CFR 261.31 (F-listed) and 261.33 (P & Unlisted) were discharged to the PEW system. Results of this investigation will be used to support revisions to the RCRA Part A Permit application.« less

  12. Protein Kinase CK2 Content in GL261 Mouse Glioblastoma.

    PubMed

    Ferrer-Font, Laura; Alcaraz, Estefania; Plana, Maria; Candiota, Ana Paula; Itarte, Emilio; Arús, Carles

    2016-07-01

    Glioblastoma (GBM) is the most prevalent and aggressive human glial tumour with a median survival of 14-15 months. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment. Unfortunately, chemoresistence always ensues with concomitant tumour regrowth. Protein kinase CK2 (CK2) contributes to tumour development, proliferation, and suppression of apoptosis in cancer and it is overexpressed in human GBM. Targeting CK2 in GBM treatment may benefit patients. With this translational perspective in mind, we have studied the CK2 expression level by Western blot analysis in a preclinical model of GBM: GL261 cells growing orthotopically in C57BL/6 mice. The expression level of the CK2 catalytic subunit (CK2α) was higher in tumour (about 4-fold) and in contralateral brain parenchyma (more than 2-fold) than in normal brain parenchyma (p < 0.05). In contrast, no significant changes were found in CK2 regulatory subunit (CK2β) expression, suggesting an increased unbalance of CK2α/CK2β in GL261 tumours with respect to normal brain parenchyma, in agreement with a differential role of these two subunits in tumours.

  13. Rapid herpes simplex virus detection in clinical samples submitted to a state virology laboratory.

    PubMed

    Mayo, D R; Brennan, T; Egbertson, S H; Moore, D F

    1985-05-01

    Of 16,779 specimens received for herpes simplex virus (HSV) isolation since 1982, 4,465 (26.6%) were positive for HSV by either standard tissue culture or an antigen detection system (peroxidase-antiperoxidase; PAP). The overall isolation rate for genital vesicle specimens was lower (26.1%) than that for nongenital specimens (29.3%). Monthly isolation rates ranged from 19 to 32% for genital specimens and from 20 to 44% for nongenital specimens. Increasing demands for HSV isolation led to comparison of tissue culture with PAP. In the first comparison, HSV was isolated in single human fibroblast cell cultures from 1,019 of 4,261 specimens (23.9%), whereas single human fibroblast wells stained at 24 and 72 h postinoculation were PAP positive for 1,007 of 4,261 specimens (23.6%). In the second comparison, HSV was isolated from 225 of 1,026 (21.9%) specimens and duplicate human foreskin fibroblast cell wells stained at 24 and 72 h were PAP positive in 241 of 1,026 (23.5%). With the dual-well PAP system, all results were reported within 72 h, approximately 70% of positives were reported within 24 h, and considerable savings in time and materials resulted.

  14. Molecular Characterization of Heterologous HIV-1gp120 Gene Expression Disruption in Mycobacterium bovis BCG Host Strain: A Critical Issue for Engineering Mycobacterial Based-Vaccine Vectors

    PubMed Central

    Joseph, Joan; Fernández-Lloris, Raquel; Pezzat, Elías; Saubi, Narcís; Cardona, Pere-Joan; Mothe, Beatriz; Gatell, Josep Maria

    2010-01-01

    Mycobacterium bovis Bacillus Calmette-Guérin (BCG) as a live vector of recombinant bacterial vaccine is a promising system to be used. In this study, we evaluate the disrupted expression of heterologous HIV-1gp120 gene in BCG Pasteur host strain using replicative vectors pMV261 and pJH222. pJH222 carries a lysine complementing gene in BCG lysine auxotrophs. The HIV-1 gp120 gene expression was regulated by BCG hsp60 promoter (in plasmid pMV261) and Mycobacteria spp. α-antigen promoter (in plasmid pJH222). Among 14 rBCG:HIV-1gp120 (pMV261) colonies screened, 12 showed a partial deletion and two showed a complete deletion. However, deletion was not observed in all 10 rBCG:HIV-1gp120 (pJH222) colonies screened. In this study, we demonstrated that E. coli/Mycobacterial expression vectors bearing a weak promoter and lysine complementing gene in a recombinant lysine auxotroph of BCG could prevent genetic rearrangements and disruption of HIV 1gp120 gene expression, a key issue for engineering Mycobacterial based vaccine vectors. PMID:20617151

  15. Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography?

    PubMed

    Kamal, Rasha M; Helal, Maha H; Mansour, Sahar M; Haggag, Marwa A; Nada, Omniya M; Farahat, Iman G; Alieldin, Nelly H

    2016-07-12

    To assess the feasibility of using the MRI breast imaging reporting and data system (BI-RADS) lexicon morphology descriptors to characterize enhancing breast lesions identified on contrast-enhanced spectral mammography (CESM). The study is a retrospective analysis of the morphology descriptors of 261 enhancing breast lesions identified on CESM in 239 patients. We presented the morphological categorization of the included lesions into focus, mass and non-mass. Further classifications included (1) the multiplicity for "focus" category, (2) the shape, margin and internal enhancement for "mass" category and (3) the distribution and internal enhancement for "non-mass" category. Each morphology descriptor was evaluated individually (irrespective of all other descriptors) by calculating its sensitivity, specificity, positive-predictive value (PPV) and negative-predictive value (NPV) and likelihood ratios (LRs). The study included 68/261 (26.1%) benign lesions and 193/261 (73.9%) malignant lesions. Intensely enhancing foci, whether single (7/12, 58.3%) or multiple (2/12, 16.7%), were malignant. Descriptors of "irregular"-shape (PPV: 92.4%) and "non-circumscribed" margin (odds ratio: 55.2, LR positive: 4.77; p-value: <0.001) were more compatible with malignancy. Internal mass enhancement patterns showed a very low specificity (58.0%) and NPV (40.0%). Non-mass enhancement (NME) was detected in 81/261 lesions. Asymmetrical NME in 81% (n = 52/81) lesions was malignant lesions and internal enhancement patterns indicative of malignancy were the heterogeneous and clumped ones. We can apply the MRI morphology descriptors to characterize lesions on CESM, but with few expectations. In many situations, irregular-shaped, non-circumscribed masses and NME with focal, ductal or segmental distribution and heterogeneous or clumped enhancement are the most suggestive descriptors of malignant pathologies. (1) The MRI BI-RADS lexicon morphology descriptors can be applied in the characterization of enhancing lesions on CESM with a few exceptions. (2) Multiple bilateral intensely enhancing foci should not be included under the normal background parenchymal enhancement unless they are proved to be benign by biopsy. (3) Mass lesion features that indicated malignancy were irregular-shaped, spiculated and irregular margins and heterogeneous internal enhancement patterns. The rim enhancement pattern should not be considered as a descriptor of malignant lesions unless CESM is coupled with an ultrasound examination.

  16. Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography?

    PubMed Central

    Kamal, Rasha M; Helal, Maha H; Haggag, Marwa A; Nada, Omniya M; Farahat, Iman G; Alieldin, Nelly H

    2016-01-01

    Objective: To assess the feasibility of using the MRI breast imaging reporting and data system (BI-RADS) lexicon morphology descriptors to characterize enhancing breast lesions identified on contrast-enhanced spectral mammography (CESM). Methods: The study is a retrospective analysis of the morphology descriptors of 261 enhancing breast lesions identified on CESM in 239 patients. We presented the morphological categorization of the included lesions into focus, mass and non-mass. Further classifications included (1) the multiplicity for “focus” category, (2) the shape, margin and internal enhancement for “mass” category and (3) the distribution and internal enhancement for “non-mass” category. Each morphology descriptor was evaluated individually (irrespective of all other descriptors) by calculating its sensitivity, specificity, positive-predictive value (PPV) and negative-predictive value (NPV) and likelihood ratios (LRs). Results: The study included 68/261 (26.1%) benign lesions and 193/261 (73.9%) malignant lesions. Intensely enhancing foci, whether single (7/12, 58.3%) or multiple (2/12, 16.7%), were malignant. Descriptors of “irregular”-shape (PPV: 92.4%) and “non-circumscribed” margin (odds ratio: 55.2, LR positive: 4.77; p-value: <0.001) were more compatible with malignancy. Internal mass enhancement patterns showed a very low specificity (58.0%) and NPV (40.0%). Non-mass enhancement (NME) was detected in 81/261 lesions. Asymmetrical NME in 81% (n = 52/81) lesions was malignant lesions and internal enhancement patterns indicative of malignancy were the heterogeneous and clumped ones. Conclusion: We can apply the MRI morphology descriptors to characterize lesions on CESM, but with few expectations. In many situations, irregular-shaped, non-circumscribed masses and NME with focal, ductal or segmental distribution and heterogeneous or clumped enhancement are the most suggestive descriptors of malignant pathologies. Advances in knowledge: (1) The MRI BI-RADS lexicon morphology descriptors can be applied in the characterization of enhancing lesions on CESM with a few exceptions. (2) Multiple bilateral intensely enhancing foci should not be included under the normal background parenchymal enhancement unless they are proved to be benign by biopsy. (3) Mass lesion features that indicated malignancy were irregular-shaped, spiculated and irregular margins and heterogeneous internal enhancement patterns. The rim enhancement pattern should not be considered as a descriptor of malignant lesions unless CESM is coupled with an ultrasound examination. PMID:27327403

  17. RCRA/UST, superfund and EPCRA hotline training module. Introduction to: Definition of solid waste and hazardous waste recycling (40 CFR sections 261.2 and 261.9) updated as of July 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-11-01

    The module explains the statutory and regulatory definitions of solid waste, including the standards governing the recycling and management of specific types of wastes. It lists and cites three use/reuse scenarios where the materials are not solid wastes and states the requirements for documentation. It lists examples of sham recycling and describes the conditions under which hazardous waste-derived products may be excluded from regulation. It cites the provisions for precious metal recovery and discusses potential regulatory developments affecting the definition of solid waste and hazardous waste recycling.

  18. X-Ray source populations in old open clusters: Collinder 261

    NASA Astrophysics Data System (ADS)

    Vats, Smriti; van den Berg, Maureen; Wijnands, Rudy

    2014-09-01

    We are carrying out an X-ray survey of old open clusters with the Chandra X-ray Observatory. Single old stars, being slow rotators, are very faint in X-rays (L_X < 1×10^27 erg/s). Hence, X-rays produced by mass transfer in cataclysmic variables (CVs) or by rapid rotation of the stars in tidally locked, detached binaries (active binaries; ABs) can be detected, without contamination from single stars. By comparing the properties of various types of interacting binaries in different environments (the Galactic field, old open clusters, globular clusters), we aim to study binary evolution and how it may be affected by dynamical encounters with other cluster stars. Stellar clusters are good targets to study binaries, as age, distance, chemical composition, are well constrained. Collinder (Cr) 261 is an old open cluster (age ~ 7 Gyr), with one of the richest populations inferred of close binaries and blue stragglers of all open clusters and is therefore an obvious target to study the products of close encounters in open clusters. We will present the first results of this study, detailing the low-luminosity X-ray population of Cr 261, in conjunction with other open clusters in our survey (NGC 188, Berkeley 17, NGC 6253, M67, NGC 6791) and in comparison with populations in globular clusters.

  19. 36 CFR 261.53 - Special closures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... communities. (c) Objects or areas of historical, archeological, geological, or paleontological interest. (d) Scientific experiments or investigations. (e) Public health or safety. (f) Property. ...

  20. Truly selective primary IgM deficiency is probably very rare.

    PubMed

    Janssen, L M A; Macken, T; Creemers, M C W; Pruijt, J F M; Eijk, J J J; de Vries, E

    2018-02-01

    Isolated decreased serum-immunoglobulin (Ig)M has been associated with severe and/or recurrent infections, atopy and autoimmunity. However, the reported high prevalence of clinical problems in IgM-deficient patients may reflect the skewed tertiary centre population studied so far. Also, many papers on IgM deficiency have included patients with more abnormalities than simply IgM-deficiency. We studied truly selective primary IgM deficiency according to the diagnostic criteria of the European Society for Immunodeficiencies (ESID) (true sIgMdef) by reviewing the literature (261 patients with primary decreased serum-IgM in 46 papers) and analysing retrospectively all patients with decreased serum-IgM in a large teaching hospital in 's-Hertogenbosch, the Netherlands [1 July 2005-23 March 2016; n = 8049 IgM < 0·4 g/l; n = 2064 solitary (IgG+IgA normal/IgM < age-matched reference)]. A total of 359 of 2064 (17%) cases from our cohort had primary isolated decreased serum-IgM, proven persistent in 45 of 359 (13%) cases; their medical charts were reviewed. Our main finding is that true sIgMdef is probably very rare. Only six of 261 (2%) literature cases and three of 45 (7%) cases from our cohort fulfilled the ESID criteria completely; 63 of 261 (24%) literature cases also had other immunological abnormalities and fulfilled the criteria for unclassified antibody deficiencies (unPAD) instead. The diagnosis was often uncertain (possible sIgMdef): data on IgG subclasses and/or vaccination responses were lacking in 192 of 261 (74%) literature cases and 42 of 45 (93%) cases from our cohort. Our results also illustrate the clinical challenge of determining the relevance of a serum sample with decreased IgM; a larger cohort of true sIgMdef patients is needed to explore fully its clinical consequences. The ESID online Registry would be a useful tool for this. © 2017 British Society for Immunology.

  1. Health status, quality of life, residential stability, substance use, and health care utilization among adults applying to a supportive housing program.

    PubMed

    Hwang, Stephen W; Gogosis, Evie; Chambers, Catharine; Dunn, James R; Hoch, Jeffrey S; Aubry, Tim

    2011-12-01

    Supportive housing, defined as subsidized housing in conjunction with site-based social services, may help improve the health and residential stability of highly disadvantaged individuals. This study examined changes in health status, quality of life, substance use, health care utilization, and residential stability among 112 homeless and vulnerably housed individuals who applied to a supportive housing program in Toronto, Canada, from December 2005 to June 2007. Follow-up interviews were conducted every 6 months for 18 months. Comparisons were made between individuals who were accepted into the program (intervention) and those who were wait-listed (usual care) using repeated-measures analyses. Individuals who were accepted into the housing program experienced significantly greater improvements in satisfaction with living situation compared with individuals in the usual care group (time, F(3,3,261) = 47.68, p < 0.01; group × time, F(3,3,261) = 14.60, p < 0.01). There were no significant differences in other quality of life measures, health status, health care utilization, or substance use between the two groups over time. Significant improvement in residential stability occurred over time, independent of assigned housing group (time, F(3,3,261) = 9.96, p < 0.01; group × time, F(3,3,261) = 1.74, p = 0.17). The ability to examine the effects of supportive housing on homeless individuals was limited by the small number of participants who were literally homeless at baseline and by the large number of participants who gained stable housing during the study period regardless of their assigned housing status. Nonetheless, this study shows that highly disadvantaged individuals with a high prevalence of poor physical and mental health and substance use can achieve stable housing.

  2. Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas.

    PubMed

    Towner, Rheal A; Smith, Nataliya; Saunders, Debra; De Souza, Patricia Coutinho; Henry, Leah; Lupu, Florea; Silasi-Mansat, Robert; Ehrenshaft, Marilyn; Mason, Ronald P; Gomez-Mejiba, Sandra E; Ramirez, Dario C

    2013-12-01

    Free radicals play a major role in gliomas. By combining immuno-spin-trapping (IST) and molecular magnetic resonance imaging (mMRI), in vivo levels of free radicals were detected within mice bearing orthotopic GL261 gliomas. The nitrone spin trap DMPO (5,5-dimethyl pyrroline N-oxide) was administered prior to injection of an anti-DMPO probe (anti-DMPO antibody covalently bound to a bovine serum albumin (BSA)-Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-biotin MRI contrast agent) to trap tumor-associated free radicals. mMRI detected the presence of anti-DMPO adducts by either a significant sustained increase (p<0.001) in MR signal intensity or a significant decrease (p<0.001) in T1 relaxation, measured as %T1 change. In vitro assessment of the anti-DMPO probe indicated a significant decrease (p<0.0001) in T1 relaxation in GL261 cells that were oxidatively stressed with hydrogen peroxide, compared to controls. The biotin moiety of the anti-DMPO probe was targeted with fluorescently-labeled streptavidin to locate the anti-DMPO probe in excised brain tissues. As a negative control a non-specific IgG antibody covalently bound to the albumin-Gd-DTPA-biotin construct was used. DMPO adducts were also confirmed in tumor tissue from animals administered DMPO, compared to non-tumor brain tissue. GL261 gliomas were found to have significantly increased malondialdehyde (MDA) protein adducts (p<0.001) and 3-nitrotyrosine (3-NT) (p<0.05) compared to normal mouse brain tissue, indicating increased oxidized lipids and proteins, respectively. Co-localization of the anti-DMPO probe with either 3-NT or 4-hydroxynonenal was also observed. This is the first report regarding the detection of in vivo levels of free radicals from a glioma model. © 2013.

  3. Coronary heart disease risk factors in adult premenopausal white women with polycystic ovary syndrome compared with a healthy female population.

    PubMed

    Glueck, Charles J; Morrison, John A; Goldenberg, Naila; Wang, Ping

    2009-05-01

    Our specific aim was to determine whether coronary heart disease (CHD) risk factors in polycystic ovary syndrome (PCOS) patients were independent of their higher body mass index (BMI) and centripetal obesity. In adult, premenopausal, white women, CHD risk factors were compared between 488 patients with well-defined PCOS and 351 healthy free-living population controls from the Princeton Follow-up Study (PFS). After excluding women with irregular menses (putative PCOS phenotypes), comparisons were also made between the 261 PFS women with a history of regular menses and the 488 women with PCOS. Fasting lipids, insulin, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), HOMA insulin secretion, blood pressure, BMI, and waist circumference were measured. Compared with both the full cohort of 351 PFS women and the subgroup of 261 PFS women with regular menses, women with PCOS had higher BMI, waist circumference, total and low-density lipoprotein cholesterol, triglyceride, systolic blood pressure, diastolic blood pressure, insulin, glucose, and HOMA-IR (all Ps < or = .005). After adjusting for age and BMI, women with PCOS, compared with the 351 and 261 PFS women, had lower high-density lipoprotein cholesterol (P < .0001, .0008) and higher systolic blood pressure (P = .0002, < .0001), insulin (P = .017, .039), HOMA-IR (P = .013, .032), and HOMA insulin secretion (P = .022, .037). The small subgroup of PCOS women with normal BMI (<25 kg/m(2)) (36/488, 7%) also had higher age-adjusted insulin, glucose, and HOMA-IR (all Ps < .005) than the subgroup of PFS women with BMI less than 25 kg/m(2) (123/261, 47%). Increased CHD risk factors and high HOMA-IR in PCOS cannot be exclusively attributed to their preponderant centripetal obesity. Identification of women with clinical features of PCOS should alert the clinician to potentially increased risk for CHD and prompt CHD risk factor testing.

  4. Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field.

    PubMed

    Hamdous, Yasmina; Chebbi, Imène; Mandawala, Chalani; Le Fèvre, Raphael; Guyot, François; Seksek, Olivier; Alphandéry, Edouard

    2017-10-17

    Biologics magnetics nanoparticles, magnetosomes, attract attention because of their magnetic characteristics and potential applications. The aim of the present study was to develop and characterize novel magnetosomes, which were extracted from magnetotactic bacteria, purified to produce apyrogen magnetosome minerals, and then coated with Chitosan, Neridronate, or Polyethyleneimine. It yielded stable magnetosomes designated as M-Chi, M-Neri, and M-PEI, respectively. Nanoparticle biocompatibility was evaluated on mouse fibroblast cells (3T3), mouse glioblastoma cells (GL-261) and rat glioblastoma cells (RG-2). We also tested these nanoparticles for magnetic hyperthermia treatment of tumor in vitro on two tumor cell lines GL-261 and RG-2 under the application of an alternating magnetic field. Heating, efficacy and internalization properties were then evaluated. Nanoparticles coated with chitosan, polyethyleneimine and neridronate are apyrogen, biocompatible and stable in aqueous suspension. The presence of a thin coating in M-Chi and M-PEI favors an arrangement in chains of the magnetosomes, similar to that observed in magnetosomes directly extracted from magnetotactic bacteria, while the thick matrix embedding M-Neri leads to structures with an average thickness of 3.5 µm 2 per magnetosome mineral. In the presence of GL-261 cells and upon the application of an alternating magnetic field, M-PEI and M-Chi lead to the highest specific absorption rates of 120-125 W/g Fe . Furthermore, while M-Chi lead to rather low rates of cellular internalization, M-PEI strongly associate to cells, a property modulated by the application of an alternating magnetic field. Coating of purified magnetosome minerals can therefore be chosen to control the interactions of nanoparticles with cells, organization of the minerals, as well as heating and cytotoxicity properties, which are important parameters to be considered in the design of a magnetic hyperthermia treatment of tumor.

  5. 21 CFR 558.261 - Florfenicol.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis... streptococcal septicemia associated with Streptococcus iniae Feed as a sole ration for 10 consecutive days to...

  6. SOLVENT HOLD TANK SAMPLE RESULTS FOR MCU-14-259/260/261 AND MCU-14-315/316/317: APRIL AND MAY 2014 MONTHLY SAMPLES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fondeur, F.; Taylor-Pashow, K.

    2014-08-05

    SRNL received two sets of SHT samples (MCU-14-259/260/261 in April 2014 and MCU-14- 315/316/317 in May 2014) for analysis. The samples were analyzed for composition. Both samples have similar chemical composition. As with the previous solvent sample results, these analyses indicate that the solvent does not require Isopar® L trimming at this time. Since an addition of TiDG and MaxCalix to the SHT was added in early July 2014, the solvent does not require TiDG addition at this time. The current TiDG level (1.5 mM) is above the minimum recommended operating level of 1 mM.

  7. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  8. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  9. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  10. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  11. 21 CFR 558.261 - Florfenicol.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis... septicemia associated with Streptococcus iniae Feed as a sole ration for 10 consecutive days to deliver 15 mg...

  12. Functional dissection of the alphavirus capsid protease: sequence requirements for activity.

    PubMed

    Thomas, Saijo; Rai, Jagdish; John, Lijo; Günther, Stephan; Drosten, Christian; Pützer, Brigitte M; Schaefer, Stephan

    2010-11-18

    The alphavirus capsid is multifunctional and plays a key role in the viral life cycle. The nucleocapsid domain is released by the self-cleavage activity of the serine protease domain within the capsid. All alphaviruses analyzed to date show this autocatalytic cleavage. Here we have analyzed the sequence requirements for the cleavage activity of Chikungunya virus capsid protease of genus alphavirus. Amongst alphaviruses, the C-terminal amino acid tryptophan (W261) is conserved and found to be important for the cleavage. Mutating tryptophan to alanine (W261A) completely inactivated the protease. Other amino acids near W261 were not having any effect on the activity of this protease. However, serine protease inhibitor AEBSF did not inhibit the activity. Through error-prone PCR we found that isoleucine 227 is important for the effective activity. The loss of activity was analyzed further by molecular modelling and comparison of WT and mutant structures. It was found that lysine introduced at position 227 is spatially very close to the catalytic triad and may disrupt electrostatic interactions in the catalytic site and thus inactivate the enzyme. We are also examining other sequence requirements for this protease activity. We analyzed various amino acid sequence requirements for the activity of ChikV capsid protease and found that amino acids outside the catalytic triads are important for the activity.

  13. Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling.

    PubMed

    a Dzaye, Omar Dildar; Hu, Feng; Derkow, Katja; Haage, Verena; Euskirchen, Philipp; Harms, Christoph; Lehnardt, Seija; Synowitz, Michael; Wolf, Susanne A; Kettenmann, Helmut

    2016-05-01

    Peripheral macrophages and resident microglia constitute the dominant glioma-infiltrating cells. The tumor induces an immunosuppressive and tumor-supportive phenotype in these glioma-associated microglia/brain macrophages (GAMs). A subpopulation of glioma cells acts as glioma stem cells (GSCs). We explored the interaction between GSCs and GAMs. Using CD133 as a marker of stemness, we enriched for or deprived the mouse glioma cell line GL261 of GSCs by fluorescence-activated cell sorting (FACS). Over the same period of time, 100 CD133(+ )GSCs had the capacity to form a tumor of comparable size to the ones formed by 10,000 CD133(-) GL261 cells. In IL-6(-/-) mice, only tumors formed by CD133(+ )cells were smaller compared with wild type. After stimulation of primary cultured microglia with medium from CD133-enriched GL261 glioma cells, we observed an selective upregulation in microglial IL-6 secretion dependent on Toll-like receptor (TLR) 4. Our results show that GSCs, but not the bulk glioma cells, initiate microglial IL-6 secretion via TLR4 signaling and that IL-6 regulates glioma growth by supporting GSCs. Using human glioma tissue, we could confirm the finding that GAMs are the major source of IL-6 in the tumor context. © 2016 American Association of Neuropathologists, Inc. All rights reserved.

  14. Cloud Atlas: Discovery of Rotational Spectral Modulations in a Low-mass, L-type Brown Dwarf Companion to a Star

    NASA Astrophysics Data System (ADS)

    Manjavacas, Elena; Apai, Dániel; Zhou, Yifan; Karalidi, Theodora; Lew, Ben W. P.; Schneider, Glenn; Cowan, Nicolas; Metchev, Stan; Miles-Páez, Paulo A.; Burgasser, Adam J.; Radigan, Jacqueline; Bedin, Luigi R.; Lowrance, Patrick J.; Marley, Mark S.

    2018-01-01

    Observations of rotational modulations of brown dwarfs and giant exoplanets allow the characterization of condensate cloud properties. As of now, rotational spectral modulations have only been seen in three L-type brown dwarfs. We report here the discovery of rotational spectral modulations in LP261-75B, an L6-type intermediate surface gravity companion to an M4.5 star. As a part of the Cloud Atlas Treasury program, we acquired time-resolved Wide Field Camera 3 grism spectroscopy (1.1–1.69 μm) of LP261-75B. We find gray spectral variations with the relative amplitude displaying only a weak wavelength dependence and no evidence for lower-amplitude modulations in the 1.4 μm water band than in the adjacent continuum. The likely rotational modulation period is 4.78 ± 0.95 hr, although the rotational phase is not well sampled. The minimum relative amplitude in the white light curve measured over the whole wavelength range is 2.41% ± 0.14%. We report an unusual light curve, which seems to have three peaks approximately evenly distributed in rotational phase. The spectral modulations suggests that the upper atmosphere cloud properties in LP261-75B are similar to two other mid-L dwarfs of typical infrared colors, but differ from that of the extremely red L-dwarf WISE0047.

  15. Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome.

    PubMed

    Pannone, Luca; Bocchinfuso, Gianfranco; Flex, Elisabetta; Rossi, Cesare; Baldassarre, Giuseppina; Lissewski, Christina; Pantaleoni, Francesca; Consoli, Federica; Lepri, Francesca; Magliozzi, Monia; Anselmi, Massimiliano; Delle Vigne, Silvia; Sorge, Giovanni; Karaer, Kadri; Cuturilo, Goran; Sartorio, Alessandro; Tinschert, Sigrid; Accadia, Maria; Digilio, Maria C; Zampino, Giuseppe; De Luca, Alessandro; Cavé, Hélène; Zenker, Martin; Gelb, Bruce D; Dallapiccola, Bruno; Stella, Lorenzo; Ferrero, Giovanni B; Martinelli, Simone; Tartaglia, Marco

    2017-04-01

    Germline mutations in PTPN11, the gene encoding the Src-homology 2 (SH2) domain-containing protein tyrosine phosphatase (SHP2), cause Noonan syndrome (NS), a relatively common, clinically variable, multisystem disorder. Here, we report on the identification of five different PTPN11 missense changes affecting residues Leu 261 , Leu 262 , and Arg 265 in 16 unrelated individuals with clinical diagnosis of NS or with features suggestive for this disorder, specifying a novel disease-causing mutation cluster. Expression of the mutant proteins in HEK293T cells documented their activating role on MAPK signaling. Structural data predicted a gain-of-function role of substitutions at residues Leu 262 and Arg 265 exerted by disruption of the N-SH2/PTP autoinhibitory interaction. Molecular dynamics simulations suggested a more complex behavior for changes affecting Leu 261 , with possible impact on SHP2's catalytic activity/selectivity and proper interaction of the PTP domain with the regulatory SH2 domains. Consistent with that, biochemical data indicated that substitutions at codons 262 and 265 increased the catalytic activity of the phosphatase, while those affecting codon 261 were only moderately activating but impacted substrate specificity. Remarkably, these mutations underlie a relatively mild form of NS characterized by low prevalence of cardiac defects, short stature, and cognitive and behavioral issues, as well as less evident typical facial features. © 2017 WILEY PERIODICALS, INC.

  16. 47 CFR 87.261 - Scope of service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... economical operation of aircraft, such as fuel, weather, position reports, aircraft performance, and essential services and supplies. Public correspondence is prohibited. (b) Service must be provided to any...

  17. 24 CFR 203.261 - Calculation of periodic MIP.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums...

  18. 24 CFR 203.261 - Calculation of periodic MIP.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums...

  19. 36 CFR 261.70 - Issuance of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Protection of property, roads, or trails. (4) Protection of threatened, endangered, rare, unique, or vanishing species of plants, animals, birds or fish, or special biological communities. (5) Protection of...

  20. Treadmill Kinematics Baseline Data Collection

    NASA Image and Video Library

    2011-05-12

    PHOTO DATE: 5-12-11 LOCATION: Building 261 - Room 138 SUBJECT: Expedition 29 Preflight Training with Dan Burbank during Treadmill Kinematics Baseline Data Collection. WORK ORDER: 2011-1214 PHOTOGRAPHER: Lauren Harnett

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