Sample records for bohrium 262

  1. Odd-Z Transactinide Compound Nucleus Reactions Including the Discovery of 260Bh

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, Sarah L.

    Several reactions producing odd-Z transactinide compound nuclei were studiedwith the 88-Inch Cyclotron and the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory. The goal was to produce the same compound nucleus ator near the same excitation energy with similar values of angular momentum via differentnuclear reactions. In doing so, it can be determined if there is a preference in entrancechannel, because under these experimental conditions the survival portion of Swiatecki, Siwek-Wilcznska, and Wilczynski's"Fusion By Diffusion" model is nearly identical forthe two reactions. Additionally, because the same compound nucleus is produced, theexit channel is the same. Four compound nuclei were examined in this study: 258Db, 262Bh, 266Mt, and 272Rg. These nuclei were produced by using very similar heavy-ion induced-fusion reactions which differ only by one proton in the projectile or target nucleus (e.g.: 50Ti + 209Bi vs. 51V + 208Pb). Peak 1n exit channel cross sections were determined for each reaction in each pair, and three of the four pairs' cross sections were identical within statistical uncertainties. This indicates there is not an obvious preference of entrancechannel in these paired reactions. Charge equilibration immediately prior to fusionleading to a decreased fusion barrier is the likely cause of this phenomenon. In addition to this systematic study, the lightest isotope of element 107, bohrium, was discovered in the 209Bi( 52Cr,n) reaction. 260Bh was found to decay by emission of a 10.16 MeV alpha particle with a half-life of 35more » $$+19\\atop{-9}$$ ms. The cross section is 59 pb at an excitation energy of 15.0 MeV. The effect of the N = 152 shell is also seen in this isotope's alpha particle energy, the first evidence of such an effect in Bh. All reactions studied are also compared to model predictions by Swiatecki, Siwek-Wilcznska, and Wilczynski 's" Fusion By Diffusion " theory.« less

  2. Road dust and its effect on human health: a literature review

    PubMed Central

    2018-01-01

    The purpose of this study was to determine the effects of road dust on human health. A PubMed search was used to extract references that included the words “road dust” and “health” or “fugitive dust” and “health” in the title or abstract. A total of 46 references were extracted and selected for review after the primary screening of 949 articles. The respiratory system was found to be the most affected system in the human body. Lead, platinum-group elements (platinum, rhodium, and bohrium), aluminum, zinc, vanadium, and polycyclic aromatic hydrocarbons were the components of road dust that were most frequently referenced in the articles reviewed. Road dust was found to have harmful effects on the human body, especially on the respiratory system. To determine the complex mechanism of action of various components of road dust on the human body and the results thereof, the authors recommend a further meta-analysis and extensive risk-assessment research into the health impacts of dust exposure. PMID:29642653

  3. Comparative Effect of an Addition of a Surface Term to Woods-Saxon Potential on Thermodynamics of a Nucleon

    NASA Astrophysics Data System (ADS)

    Lütfüoğlu, B. C.

    2018-01-01

    In this study, we reveal the difference between Woods-Saxon (WS) and Generalized Symmetric Woods-Saxon (GSWS) potentials in order to describe the physical properties of a nucleon, by means of solving Schrödinger equation for the two potentials. The additional term squeezes the WS potential well, which leads an upward shift in the spectrum, resulting in a more realistic picture. The resulting GSWS potential does not merely accommodate extra quasi bound states, but also has modified bound state spectrum. As an application, we apply the formalism to a real problem, an α particle confined in Bohrium-270 nucleus. The thermodynamic functions Helmholtz energy, entropy, internal energy, specific heat of the system are calculated and compared for both wells. The internal energy and the specific heat capacity increase as a result of upward shift in the spectrum. The shift of the Helmholtz free energy is a direct consequence of the shift of the spectrum. The entropy decreases because of a decrement in the number of available states. Supported by the Turkish Science and Research Council (TÜBİTAK) and Akdeniz University

  4. 77 FR 12933 - Federal Acquisition Regulation: Trade Agreements Thresholds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ...: --Canada 25,000 77,494 10,074,262 --Mexico 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262... 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262 Peru FTA 202,000 202,000 7,777,000...

  5. 40 CFR 262.27 - Waste minimization certification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Waste minimization certification. 262.27 Section 262.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.27 Waste minimization...

  6. 40 CFR 262.27 - Waste minimization certification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Waste minimization certification. 262.27 Section 262.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.27 Waste minimization...

  7. 40 CFR 262.27 - Waste minimization certification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Waste minimization certification. 262.27 Section 262.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.27 Waste minimization...

  8. 40 CFR 262.27 - Waste minimization certification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Waste minimization certification. 262.27 Section 262.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.27 Waste minimization...

  9. 40 CFR 262.27 - Waste minimization certification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Waste minimization certification. 262.27 Section 262.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.27 Waste minimization...

  10. 40 CFR 262.70 - Farmers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Farmers. 262.70 Section 262.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Farmers § 262.70 Farmers. A farmer disposing of waste pesticides...

  11. 40 CFR 262.30 - Packaging.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Packaging. 262.30 Section 262.30... APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Pre-Transport Requirements § 262.30 Packaging. Before... the waste in accordance with the applicable Department of Transportation regulations on packaging...

  12. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Pumping equipment. 195.262 Section 195.262... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment...

  13. 39 CFR 262.3 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Information. 262.3 Section 262.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.3 Information. Data combined with the knowledge of its context and having the potential to...

  14. 39 CFR 262.3 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Information. 262.3 Section 262.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.3 Information. Data combined with the knowledge of its context and having the potential to...

  15. 39 CFR 262.3 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Information. 262.3 Section 262.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.3 Information. Data combined with the knowledge of its context and having the potential to...

  16. 39 CFR 262.3 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Information. 262.3 Section 262.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.3 Information. Data combined with the knowledge of its context and having the potential to...

  17. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope of the laboratory environmental management standard? The Laboratory Environmental Management Standard... environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION...

  18. 39 CFR 262.3 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Information. 262.3 Section 262.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.3 Information. Data combined with the knowledge of its context and having the potential to...

  19. 39 CFR 262.7 - Non-records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Non-records. 262.7 Section 262.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.7 Non-records. (a) Non-record material. Includes blank forms and surplus publications...

  20. 39 CFR 262.7 - Non-records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Non-records. 262.7 Section 262.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.7 Non-records. (a) Non-record material. Includes blank forms and surplus publications...

  1. 39 CFR 262.7 - Non-records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Non-records. 262.7 Section 262.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.7 Non-records. (a) Non-record material. Includes blank forms and surplus publications...

  2. 39 CFR 262.7 - Non-records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Non-records. 262.7 Section 262.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.7 Non-records. (a) Non-record material. Includes blank forms and surplus publications...

  3. 39 CFR 262.7 - Non-records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Non-records. 262.7 Section 262.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.7 Non-records. (a) Non-record material. Includes blank forms and surplus publications...

  4. 40 CFR 262.207 - Training.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Training. 262.207 Section 262.207... Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.207 Training. An eligible academic entity must provide training to all individuals working in a laboratory at the eligible...

  5. 49 CFR 262.7 - Eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Eligibility. 262.7 Section 262.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION IMPLEMENTATION OF PROGRAM FOR CAPITAL GRANTS FOR RAIL LINE RELOCATION AND IMPROVEMENT PROJECTS § 262.7 Eligibility. (a) A State is...

  6. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.105 What must be included in the laboratory environmental management plan? (a) Each University must include specific... laboratory environmental management plan? 262.105 Section 262.105 Protection of Environment ENVIRONMENTAL...

  7. 40 CFR 262.80 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Applicability. 262.80 Section 262.80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Transfrontier Shipments of Hazardous Waste for Recovery within the OECD § 262.80 Applicability. (a)...

  8. 10 CFR 431.262 - Definitions concerning commercial prerinse spray valves.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Definitions concerning commercial prerinse spray valves. 431.262 Section 431.262 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Commercial Prerinse Spray Valves § 431.262 Definitions...

  9. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Imports of hazardous waste. 262.60 Section 262.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60 Imports...

  10. 40 CFR 262.207 - Training.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... sheet(s) for training session(s); or (2) Syllabus for training session; or (3) Certificate of training... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Training. 262.207 Section 262.207... Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.207 Training. An...

  11. 38 CFR 26.2 - Applicability and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Applicability and scope. 26.2 Section 26.2 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) ENVIRONMENTAL EFFECTS OF THE DEPARTMENT OF VETERANS AFFAIRS (VA) ACTIONS § 26.2 Applicability and scope. This...

  12. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project-Laboratory Environmental Management Standard § 262.107 Under what circumstances will a university's participation in this...

  13. 40 CFR 262.41 - Biennial report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Biennial report. 262.41 Section 262.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.41 Biennial report. (a) A generator who ships any hazardous waste...

  14. 39 CFR 262.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Purpose and scope. 262.1 Section 262.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.1 Purpose and scope. This part contains the official definition of those basic records and...

  15. 39 CFR 262.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Purpose and scope. 262.1 Section 262.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.1 Purpose and scope. This part contains the official definition of those basic records and...

  16. 39 CFR 262.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Purpose and scope. 262.1 Section 262.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.1 Purpose and scope. This part contains the official definition of those basic records and...

  17. 39 CFR 262.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Purpose and scope. 262.1 Section 262.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.1 Purpose and scope. This part contains the official definition of those basic records and...

  18. 46 CFR 199.262 - Rescue boats.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Rescue boats. 199.262 Section 199.262 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Cargo Vessels § 199.262 Rescue boats. (a) Each cargo vessel must carry at least one rescue boat. Each rescue boat must be approved under approval...

  19. 46 CFR 199.262 - Rescue boats.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Rescue boats. 199.262 Section 199.262 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Cargo Vessels § 199.262 Rescue boats. (a) Each cargo vessel must carry at least one rescue boat. Each rescue boat must be approved under approval...

  20. 46 CFR 199.262 - Rescue boats.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Rescue boats. 199.262 Section 199.262 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Cargo Vessels § 199.262 Rescue boats. (a) Each cargo vessel must carry at least one rescue boat. Each rescue boat must be approved under approval...

  1. 46 CFR 199.262 - Rescue boats.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Rescue boats. 199.262 Section 199.262 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Cargo Vessels § 199.262 Rescue boats. (a) Each cargo vessel must carry at least one rescue boat. Each rescue boat must be approved under approval...

  2. 46 CFR 199.262 - Rescue boats.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Rescue boats. 199.262 Section 199.262 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Cargo Vessels § 199.262 Rescue boats. (a) Each cargo vessel must carry at least one rescue boat. Each rescue boat must be approved under approval...

  3. 40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

  4. 40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

  5. 40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

  6. 40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

  7. 40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

  8. 49 CFR 262.19 - Close-out procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Close-out procedures. 262.19 Section 262.19... IMPROVEMENT PROJECTS § 262.19 Close-out procedures. (a) Thirty days before the end of the grant period, FRA will notify the State that the period of performance for the grant is about to expire and that close...

  9. 36 CFR 262.4 - Audit of expenditures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Audit of expenditures. 262.4 Section 262.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAW ENFORCEMENT SUPPORT ACTIVITIES Rewards and Payments § 262.4 Audit of expenditures. The Chief of the Forest Service shall, through appropriate directives...

  10. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Number of copies. 262.22 Section 262...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner...

  11. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Number of copies. 262.22 Section 262...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner...

  12. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Number of copies. 262.22 Section 262...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner...

  13. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope... 40 Protection of Environment 26 2014-07-01 2014-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION...

  14. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope... 40 Protection of Environment 27 2012-07-01 2012-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION...

  15. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope... 40 Protection of Environment 27 2013-07-01 2013-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION...

  16. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope... 40 Protection of Environment 26 2011-07-01 2011-07-01 false What is the scope of the laboratory environmental management standard? 262.103 Section 262.103 Protection of Environment ENVIRONMENTAL PROTECTION...

  17. 20 CFR 416.262 - Eligibility requirements for special SSI cash benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Eligibility requirements for special SSI cash benefits. 416.262 Section 416.262 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A Disabling Impairment § 416.262...

  18. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.

    PubMed

    Hsu, Tzu-Sheng; Chen, Chinpiao; Lee, Pei-Ting; Chiu, Shu-Jun; Liu, Huei-Fang; Tsai, Chih-Chien; Chao, Jui-I

    2008-10-01

    The derivatives of 5,8-quinolinedione have been shown to exert anticancer activities. A new synthetic compound 7-chloro-6-piperidin-1-yl-quinoline-5,8-dione (designed as PT-262) derived from 6,7-dichloroquinoline-5,8-dione on its anticancer activity was investigated in this study. PT-262 was synthesized as the following: triethylamine (0.56 ml, 5.1 mmol) was added dropwise to a solution of 6,7-dichloroquinoline-5,8-dione (1.00 g, 4.4 mmol) and piperidine (0.50 ml, 5.1 mmol) in 150 ml of benzene with stirring at room temperature for 5 min, and the solvent was removed using rotary evaporator to give a dark brown solid. PT-262 was purified by flash chromatography using 50% ethyl acetate/hexanes to elute that displayed as brown solids. To examine the induction of apoptosis following PT-262 treatment, the lung cancer cells were subjected to apoptotic cell observation, caspase activation, and mitochondrial functional assays. The protein levels of phosphorylated ERK and CDC2 after treatment with PT-262 were analyzed by Western blot. Treatment with 1-20 microM PT-262 for 24 h induced cytotoxicity via a concentration-dependent manner in human lung cancer cells. PT-262 induced the loss of mitochondrial membrane potential and elevated the caspase-3 activation and apoptosis. Interestingly, the phosphorylation of ERK was inhibited by PT-262. The IC50 value of ERK phosphorylation inhibition was approximate around 5 microM. Treatment with a specific MEK1/2 (the upstream of ERK) inhibitor, PD98059, increased the PT-262-induced cytotoxicity in lung cancer cells. Moreover, PT-262 did not alter the protein expression of tumor suppressor p53. PT-262 elicited the cytotoxicity and accumulated the G2/M fractions in both the p53-wild type and p53-null lung cancer cells. The mitosis-regulated protein levels of cyclin B1 and phospho-CDC2 at Thr14, Tyr15, and Thr161 were repressed by PT-262 in these cells. PT-262 suppresses the phosphorylation of ERK and CDC2 associated with proliferation inhibition via a p53-independent pathway in human lung cancer cells.

  19. 43 CFR 30.262 - When may a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... purchase: (1) Within 60 days after mailing of the probate decision unless a petition for rehearing has been... option to purchase? 30.262 Section 30.262 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE HEARINGS PROCEDURES Tribal Purchase of Interests Under Special Statutes § 30.262 When may...

  20. 29 CFR 779.262 - Excise taxes at the retail level.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Excise taxes at the retail level. 779.262 Section 779.262... Coverage Excise Taxes § 779.262 Excise taxes at the retail level. (a) Federal excise taxes are imposed at the retail level on highway vehicle fuels other than gasoline under the provisions of 26 U.S.C. 4041...

  1. 29 CFR 779.262 - Excise taxes at the retail level.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Excise taxes at the retail level. 779.262 Section 779.262... Coverage Excise Taxes § 779.262 Excise taxes at the retail level. (a) Federal excise taxes are imposed at the retail level on highway vehicle fuels other than gasoline under the provisions of 26 U.S.C. 4041...

  2. 29 CFR 779.262 - Excise taxes at the retail level.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Excise taxes at the retail level. 779.262 Section 779.262... Coverage Excise Taxes § 779.262 Excise taxes at the retail level. (a) Federal excise taxes are imposed at the retail level on highway vehicle fuels other than gasoline under the provisions of 26 U.S.C. 4041...

  3. 29 CFR 779.262 - Excise taxes at the retail level.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Excise taxes at the retail level. 779.262 Section 779.262... Coverage Excise Taxes § 779.262 Excise taxes at the retail level. (a) Federal excise taxes are imposed at the retail level on highway vehicle fuels other than gasoline under the provisions of 26 U.S.C. 4041...

  4. 42 CFR 137.262 - If the Secretary reassumes a PSFA immediately, when must the Secretary provide the Self...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... must the Secretary provide the Self-Governance Tribe with a hearing? 137.262 Section 137.262 Public... OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Reassumption § 137.262 If the Secretary reassumes a PSFA immediately, when must the Secretary provide the Self-Governance Tribe with a hearing? If the...

  5. 40 CFR 262.211 - Making the hazardous waste determination at an on-site central accumulation area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....34(a) (or § 262.34(j) and (k) for Performance Track members) for large quantity generators or § 262... Performance Track members). (d) A trained professional must determine, pursuant to § 262.11, if the unwanted... must: (1) Write the words “hazardous waste” on the container label that is affixed or attached to the...

  6. 40 CFR 262.211 - Making the hazardous waste determination at an on-site central accumulation area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....34(a) (or § 262.34(j) and (k) for Performance Track members) for large quantity generators or § 262... Performance Track members). (d) A trained professional must determine, pursuant to § 262.11, if the unwanted... must: (1) Write the words “hazardous waste” on the container label that is affixed or attached to the...

  7. 40 CFR 262.211 - Making the hazardous waste determination at an on-site central accumulation area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....34(a) (or § 262.34(j) and (k) for Performance Track members) for large quantity generators or § 262... Performance Track members). (d) A trained professional must determine, pursuant to § 262.11, if the unwanted... must: (1) Write the words “hazardous waste” on the container label that is affixed or attached to the...

  8. 40 CFR 262.211 - Making the hazardous waste determination at an on-site central accumulation area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....34(a) (or § 262.34(j) and (k) for Performance Track members) for large quantity generators or § 262... Performance Track members). (d) A trained professional must determine, pursuant to § 262.11, if the unwanted... must: (1) Write the words “hazardous waste” on the container label that is affixed or attached to the...

  9. 40 CFR 262.211 - Making the hazardous waste determination at an on-site central accumulation area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....34(a) (or § 262.34(j) and (k) for Performance Track members) for large quantity generators or § 262... Performance Track members). (d) A trained professional must determine, pursuant to § 262.11, if the unwanted... must: (1) Write the words “hazardous waste” on the container label that is affixed or attached to the...

  10. Genome sequencing and analysis of a type A Clostridium perfringens isolate from a case of bovine clostridial abomasitis.

    PubMed

    Nowell, Victoria J; Kropinski, Andrew M; Songer, J Glenn; MacInnes, Janet I; Parreira, Valeria R; Prescott, John F

    2012-01-01

    Clostridium perfringens is a common inhabitant of the avian and mammalian gastrointestinal tracts and can behave commensally or pathogenically. Some enteric diseases caused by type A C. perfringens, including bovine clostridial abomasitis, remain poorly understood. To investigate the potential basis of virulence in strains causing this disease, we sequenced the genome of a type A C. perfringens isolate (strain F262) from a case of bovine clostridial abomasitis. The ∼3.34 Mbp chromosome of C. perfringens F262 is predicted to contain 3163 protein-coding genes, 76 tRNA genes, and an integrated plasmid sequence, Cfrag (∼18 kb). In addition, sequences of two complete circular plasmids, pF262C (4.8 kb) and pF262D (9.1 kb), and two incomplete plasmid fragments, pF262A (48.5 kb) and pF262B (50.0 kb), were identified. Comparison of the chromosome sequence of C. perfringens F262 to complete C. perfringens chromosomes, plasmids and phages revealed 261 unique genes. No novel toxin genes related to previously described clostridial toxins were identified: 60% of the 261 unique genes were hypothetical proteins. There was a two base pair deletion in virS, a gene reported to encode the main sensor kinase involved in virulence gene activation. Despite this frameshift mutation, C. perfringens F262 expressed perfringolysin O, alpha-toxin and the beta2-toxin, suggesting that another regulation system might contribute to the pathogenicity of this strain. Two complete plasmids, pF262C (4.8 kb) and pF262D (9.1 kb), unique to this strain of C. perfringens were identified.

  11. Genome Sequencing and Analysis of a Type A Clostridium perfringens Isolate from a Case of Bovine Clostridial Abomasitis

    PubMed Central

    Nowell, Victoria J.; Kropinski, Andrew M.; Songer, J. Glenn; MacInnes, Janet I.; Parreira, Valeria R.; Prescott, John F.

    2012-01-01

    Clostridium perfringens is a common inhabitant of the avian and mammalian gastrointestinal tracts and can behave commensally or pathogenically. Some enteric diseases caused by type A C. perfringens, including bovine clostridial abomasitis, remain poorly understood. To investigate the potential basis of virulence in strains causing this disease, we sequenced the genome of a type A C. perfringens isolate (strain F262) from a case of bovine clostridial abomasitis. The ∼3.34 Mbp chromosome of C. perfringens F262 is predicted to contain 3163 protein-coding genes, 76 tRNA genes, and an integrated plasmid sequence, Cfrag (∼18 kb). In addition, sequences of two complete circular plasmids, pF262C (4.8 kb) and pF262D (9.1 kb), and two incomplete plasmid fragments, pF262A (48.5 kb) and pF262B (50.0 kb), were identified. Comparison of the chromosome sequence of C. perfringens F262 to complete C. perfringens chromosomes, plasmids and phages revealed 261 unique genes. No novel toxin genes related to previously described clostridial toxins were identified: 60% of the 261 unique genes were hypothetical proteins. There was a two base pair deletion in virS, a gene reported to encode the main sensor kinase involved in virulence gene activation. Despite this frameshift mutation, C. perfringens F262 expressed perfringolysin O, alpha-toxin and the beta2-toxin, suggesting that another regulation system might contribute to the pathogenicity of this strain. Two complete plasmids, pF262C (4.8 kb) and pF262D (9.1 kb), unique to this strain of C. perfringens were identified. PMID:22412860

  12. Consolidated Checklist for C3 40 CFR 262

    EPA Pesticide Factsheets

    No final rules affecting 40 CFR Part 262 were promulgated between June 30, 2002 and December 31, 2002, therefore, this Consolidated Checklist corresponds to 40 CFR Part 262 as published on July 1, 2002.

  13. The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels.

    PubMed

    Chen, Szu-Han; Fu, Ssu-Ju; Huang, Jing-Jia; Tang, Chih-Yung

    2016-01-18

    Voltage-gated potassium (Kv) channels are essential for setting neuronal membrane excitability. Mutations in human Kv1.1 channels are linked to episodic ataxia type 1 (EA1). The EA1-associated mutation I262T was identified from a patient with atypical phenotypes. Although a previous report has characterized its suppression effect, several key questions regarding the impact of the I262T mutation on Kv1.1 as well as other members of the Kv1 subfamily remain unanswered. Herein we show that the dominant-negative effect of I262T on Kv1.1 current expression is not reversed by co-expression with Kvβ1.1 or Kvβ2 subunits. Biochemical examinations indicate that I262T displays enhanced protein degradation and impedes membrane trafficking of Kv1.1 wild-type subunits. I262T appears to be the first EA1 mutation directly associated with impaired protein stability. Further functional analyses demonstrate that I262T changes the voltage-dependent activation and Kvβ1.1-mediated inactivation, uncouples inactivation from activation gating, and decelerates the kinetics of cumulative inactivation of Kv1.1 channels. I262T also exerts similar dominant effects on the gating of Kv1.2 and Kv1.4 channels. Together our data suggest that I262T confers altered channel gating and reduced functional expression of Kv1 channels, which may account for some of the phenotypes of the EA1 patient.

  14. 40 CFR 262.52 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 262.52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.52 General requirements. Exports of hazardous waste are prohibited except in compliance with the applicable requirements...

  15. 7 CFR 1822.262 - Objective.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Objective. 1822.262 Section 1822.262 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS...

  16. 40 CFR 262.50 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.50 Applicability. This subpart establishes requirements applicable to exports of hazardous waste. Except to the extent § 262.58 provides...

  17. 40 CFR 262.20 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 262.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.20 General requirements. (a)(1) A generator who transports, or offers for transport a hazardous waste for offsite treatment, storage, or...

  18. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false International agreements. 262.58 Section 262.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... International agreements. (a) Any person who exports or imports wastes that are considered hazardous under U.S...

  19. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false International agreements. 262.58 Section 262.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... International agreements. (a) Any person who exports or imports wastes that are considered hazardous under U.S...

  20. 40 CFR 262.20 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... either designate another facility or instruct the transporter to return the waste. (e) The requirements... 262.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.20 General requirements. (a)(1) A...

  1. 39 CFR 262.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Purpose and scope. 262.1 Section 262.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... information management terms that are frequently used throughout Postal Service regulations and directives. ...

  2. 77 FR 27548 - Federal Acquisition Regulation; Free Trade Agreement-Colombia

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... same as for the Bahrain FTA, Dominican Republic-Central American FTA, Chile FTA, NAFTA, Oman FTA, and... 77,494 10,074,262 --Mexico 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262 Peru FTA 202...

  3. 40 CFR 262.108 - When will this subpart expire?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false When will this subpart expire? 262.108 Section 262.108 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project...

  4. 40 CFR 262.108 - When will this subpart expire?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false When will this subpart expire? 262.108 Section 262.108 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project...

  5. 40 CFR 262.108 - When will this subpart expire?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false When will this subpart expire? 262.108 Section 262.108 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project...

  6. 40 CFR 262.108 - When will this subpart expire?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false When will this subpart expire? 262.108 Section 262.108 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project...

  7. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  8. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  9. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  10. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  11. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  12. 25 CFR 262.8 - Custody of archaeological resources.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the resources recovered (other than human remains of Indians, funerary objects, sacred objects or... may grant custody of archaeological resources (except for human remains, funerary objects, sacred... 25 Indians 1 2010-04-01 2010-04-01 false Custody of archaeological resources. 262.8 Section 262.8...

  13. 40 CFR 262.54 - Special manifest requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 262.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.54 Special... certification set forth in Item 16 of the Uniform Hazardous Waste Manifest Form: “and conforms to the terms of...

  14. 40 CFR 262.25 - Electronic manifest signatures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Electronic manifest signatures. 262.25... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.25 Electronic manifest signatures. Electronic signature methods for the e-Manifest system shall: (a) Be a legally valid and...

  15. 37 CFR 262.1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false General. 262.1 Section 262.1 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION... digital transmissions by certain Licensees in accordance with the provisions of 17 U.S.C. 114, and the...

  16. 37 CFR 262.1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false General. 262.1 Section 262.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... digital transmissions by certain Licensees in accordance with the provisions of 17 U.S.C. 114, and the...

  17. 37 CFR 262.1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false General. 262.1 Section 262.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... digital transmissions by certain Licensees in accordance with the provisions of 17 U.S.C. 114, and the...

  18. 37 CFR 262.1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false General. 262.1 Section 262.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... digital transmissions by certain Licensees in accordance with the provisions of 17 U.S.C. 114, and the...

  19. 37 CFR 262.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false General. 262.1 Section 262.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... digital transmissions by certain Licensees in accordance with the provisions of 17 U.S.C. 114, and the...

  20. 40 CFR 262.11 - Hazardous waste determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Hazardous waste determination. 262.11 Section 262.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Administrator under 40 CFR 260.21; or (2) Applying knowledge of the hazard characteristic of the waste in light...

  1. 10 CFR 431.262 - Definitions concerning commercial prerinse spray valves.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Definitions concerning commercial prerinse spray valves. 431.262 Section 431.262 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR... (or class thereof) manufactured by one manufacturer, having the same primary energy source, and which...

  2. 10 CFR 431.262 - Definitions concerning commercial prerinse spray valves.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Definitions concerning commercial prerinse spray valves. 431.262 Section 431.262 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR... (or class thereof) manufactured by one manufacturer, having the same primary energy source, and which...

  3. 10 CFR 431.262 - Definitions concerning commercial prerinse spray valves.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Definitions concerning commercial prerinse spray valves. 431.262 Section 431.262 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR... (or class thereof) manufactured by one manufacturer, having the same primary energy source, and which...

  4. 18 CFR 284.262 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... natural gas supply or capacity; or (3) An anticipated loss of natural gas supply or capacity due to a... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Definitions. 284.262 Section 284.262 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT...

  5. 41 CFR 301-10.262 - How will my agency authorize travel on Government aircraft?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from point to point) are considered travelers and must be authorized to travel on Government aircraft... authorize travel on Government aircraft? 301-10.262 Section 301-10.262 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES...

  6. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false International agreements. 262.58... International agreements. Link to an amendment published at 75 FR 1253, Jan. 8, 2010. (a) Any person who exports...: § 262.58 International agreements. (a) Any person who exports or imports wastes that are considered...

  7. 30 CFR 250.262 - What administrative information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What administrative information must accompany the DPP or DOCD? 250.262 Section 250.262 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... OUTER CONTINENTAL SHELF Plans and Information Contents of Development and Production Plans (dpp) and...

  8. 30 CFR 250.262 - What administrative information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What administrative information must accompany the DPP or DOCD? 250.262 Section 250.262 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Information Contents of Development and Production Plans (dpp) and Development Operations Coordination...

  9. 36 CFR 262.10 - Impoundment and disposal of unauthorized livestock.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... unauthorized livestock. 262.10 Section 262.10 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... unauthorized livestock. Unauthorized livestock or livestock in excess of those authorized by a grazing permit... officer determines that such livestock use is occurring, has definite knowledge of the kind of livestock...

  10. 40 CFR 262.21 - Manifest tracking numbers, manifest printing, and obtaining manifests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Manifest tracking numbers, manifest printing, and obtaining manifests. 262.21 Section 262.21 Protection of Environment ENVIRONMENTAL PROTECTION..., scanned, or faxed, except that the marginal words indicating copy distribution must be printed with a...

  11. 40 CFR 262.21 - Manifest tracking numbers, manifest printing, and obtaining manifests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Manifest tracking numbers, manifest printing, and obtaining manifests. 262.21 Section 262.21 Protection of Environment ENVIRONMENTAL PROTECTION..., scanned, and faxed, except that the marginal words indicating copy distribution must be in red ink. (5...

  12. 40 CFR 262.21 - Manifest tracking numbers, manifest printing, and obtaining manifests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Manifest tracking numbers, manifest printing, and obtaining manifests. 262.21 Section 262.21 Protection of Environment ENVIRONMENTAL PROTECTION..., scanned, or faxed, except that the marginal words indicating copy distribution must be printed with a...

  13. 40 CFR 262.21 - Manifest tracking numbers, manifest printing, and obtaining manifests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Manifest tracking numbers, manifest printing, and obtaining manifests. 262.21 Section 262.21 Protection of Environment ENVIRONMENTAL PROTECTION..., scanned, or faxed, except that the marginal words indicating copy distribution must be printed with a...

  14. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... with the U.S. EPA as a supplier of manifests (e.g., states, waste handlers, and/or commercial forms... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Imports of hazardous waste. 262.60 Section 262.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...

  15. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... with the U.S. EPA as a supplier of manifests (e.g., states, waste handlers, and/or commercial forms... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Imports of hazardous waste. 262.60 Section 262.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...

  16. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... with the U.S. EPA as a supplier of manifests (e.g., states, waste handlers, and/or commercial forms... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Imports of hazardous waste. 262.60 Section 262.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...

  17. 27 CFR 41.262 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Reports. 41.262 Section 41... TOBACCO Importation of Processed Tobacco Operations of Importers of Processed Tobacco § 41.262 Reports. (a) General. Every importer of processed tobacco must prepare a monthly report on TTB F 5220.6 in accordance...

  18. 27 CFR 41.262 - Reports.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Reports. 41.262 Section 41... TOBACCO Importation of Processed Tobacco Operations of Importers of Processed Tobacco § 41.262 Reports. (a) General. Every importer of processed tobacco must prepare a monthly report on TTB F 5220.6 in accordance...

  19. 27 CFR 41.262 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Reports. 41.262 Section 41... TOBACCO Importation of Processed Tobacco Operations of Importers of Processed Tobacco § 41.262 Reports. (a) General. Every importer of processed tobacco must prepare a monthly report on TTB F 5220.6 in accordance...

  20. 20 CFR 416.262 - Eligibility requirements for special SSI cash benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Eligibility requirements for special SSI cash benefits. 416.262 Section 416.262 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  1. 20 CFR 416.262 - Eligibility requirements for special SSI cash benefits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Eligibility requirements for special SSI cash benefits. 416.262 Section 416.262 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  2. 20 CFR 416.262 - Eligibility requirements for special SSI cash benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Eligibility requirements for special SSI cash benefits. 416.262 Section 416.262 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  3. 26 CFR 1.262-1 - Personal, living, and family expenses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Personal, living, and family expenses. 1.262-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Not Deductible § 1.262-1 Personal, living, and family... expressly provided in chapter 1 of the Code, for personal, living, and family expenses. (b) Examples of...

  4. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... compliance and how it intends to return to compliance. If, upon review of the University's written... University withdraws from this XL project, or receives a notice of termination pursuant to this section, it... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262...

  5. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... compliance and how it intends to return to compliance. If, upon review of the University's written... University withdraws from this XL project, or receives a notice of termination pursuant to this section, it... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262...

  6. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... compliance and how it intends to return to compliance. If, upon review of the University's written... University withdraws from this XL project, or receives a notice of termination pursuant to this section, it... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262...

  7. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... compliance and how it intends to return to compliance. If, upon review of the University's written... University withdraws from this XL project, or receives a notice of termination pursuant to this section, it... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262...

  8. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Impounding of dogs. 262.11... ENFORCEMENT SUPPORT ACTIVITIES Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National Forest System, which has been closed to dogs running at large, may be...

  9. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Impounding of dogs. 262.11... ENFORCEMENT SUPPORT ACTIVITIES Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National Forest System, which has been closed to dogs running at large, may be...

  10. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Impounding of dogs. 262.11... ENFORCEMENT SUPPORT ACTIVITIES Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National Forest System, which has been closed to dogs running at large, may be...

  11. Resource Conservation and Recovery Act (RCRA) Requirements for Previously Consented Exports of Hazardous Waste

    EPA Pesticide Factsheets

    Requirements for 1) Exports from Canada, Chile, Mexico, or non-OECD countries 40 CFR Part 262 Subparts A-D, and previous E 2) Exports for Recovery from OECD Countries Listed in 40 CFR Section 262.58(a)(1) 40 CFR Part 262, Subparts A-D, previous E and H.

  12. 40 CFR 273.40 - Exports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.40 Section 273.40... UNIVERSAL WASTE MANAGEMENT Standards for Large Quantity Handlers of Universal Waste § 273.40 Exports. A... exporter in 40 CFR 262.53, 262.56(a)(1) through (4), (6), and (b) and 262.57; (b) Export such universal...

  13. 40 CFR 273.20 - Exports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.20 Section 273.20... UNIVERSAL WASTE MANAGEMENT Standards for Small Quantity Handlers of Universal Waste § 273.20 Exports. A... exporter in 40 CFR 262.53, 262.56(a) (1) through (4), (6), and (b) and 262.57; (b) Export such universal...

  14. 31 CFR 26.2 - Availability of project listings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Availability of project listings. 26.2 Section 26.2 Money and Finance: Treasury Office of the Secretary of the Treasury ENVIRONMENTAL...-8191, not a toll-free call). (2) If a copy is not available from the BIC, members of the public may...

  15. 31 CFR 26.2 - Availability of project listings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Availability of project listings. 26.2 Section 26.2 Money and Finance: Treasury Office of the Secretary of the Treasury ENVIRONMENTAL...-8191, not a toll-free call). (2) If a copy is not available from the BIC, members of the public may...

  16. 31 CFR 26.2 - Availability of project listings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Availability of project listings. 26.2 Section 26.2 Money and Finance: Treasury Office of the Secretary of the Treasury ENVIRONMENTAL...-8191, not a toll-free call). (2) If a copy is not available from the BIC, members of the public may...

  17. 31 CFR 26.2 - Availability of project listings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Availability of project listings. 26.2 Section 26.2 Money and Finance: Treasury Office of the Secretary of the Treasury ENVIRONMENTAL...-8191, not a toll-free call). (2) If a copy is not available from the BIC, members of the public may...

  18. 31 CFR 26.2 - Availability of project listings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Availability of project listings. 26.2 Section 26.2 Money and Finance: Treasury Office of the Secretary of the Treasury ENVIRONMENTAL...-8191, not a toll-free call). (2) If a copy is not available from the BIC, members of the public may...

  19. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Impounding of dogs. 262.11... ENFORCEMENT SUPPORT ACTIVITIES Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National Forest System, which has been closed to dogs running at large, may be...

  20. 29 CFR 500.262 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Decision and order of Administrative Law Judge. 500.262...-Hearing Procedures § 500.262 Decision and order of Administrative Law Judge. (a) The Administrative Law... Act, modifies or vacates the decision and order of the Administrative Law Judge. (h) Except as...

  1. 29 CFR 500.262 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Decision and order of Administrative Law Judge. 500.262...-Hearing Procedures § 500.262 Decision and order of Administrative Law Judge. (a) The Administrative Law... Act, modifies or vacates the decision and order of the Administrative Law Judge. (h) Except as...

  2. 29 CFR 500.262 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Decision and order of Administrative Law Judge. 500.262...-Hearing Procedures § 500.262 Decision and order of Administrative Law Judge. (a) The Administrative Law... Act, modifies or vacates the decision and order of the Administrative Law Judge. (h) Except as...

  3. 29 CFR 500.262 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Decision and order of Administrative Law Judge. 500.262...-Hearing Procedures § 500.262 Decision and order of Administrative Law Judge. (a) The Administrative Law... Act, modifies or vacates the decision and order of the Administrative Law Judge. (h) Except as...

  4. 29 CFR 500.262 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Decision and order of Administrative Law Judge. 500.262...-Hearing Procedures § 500.262 Decision and order of Administrative Law Judge. (a) The Administrative Law... Act, modifies or vacates the decision and order of the Administrative Law Judge. (h) Except as...

  5. 26 CFR 1.262-1 - Personal, living, and family expenses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... trade or business expenses). (c) Cross references. Certain items of a personal, living, or family nature... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Personal, living, and family expenses. 1.262-1... TAX (CONTINUED) INCOME TAXES Items Not Deductible § 1.262-1 Personal, living, and family expenses. (a...

  6. 40 CFR 60.262 - Standard for particulate matter.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Standard for particulate matter. 60.262... Production Facilities § 60.262 Standard for particulate matter. (a) On and after the date on which the... furnace any gases which: (1) Exit from a control device and contain particulate matter in excess of 0.45...

  7. 40 CFR 60.262 - Standard for particulate matter.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Standard for particulate matter. 60.262... Production Facilities § 60.262 Standard for particulate matter. (a) On and after the date on which the... furnace any gases which: (1) Exit from a control device and contain particulate matter in excess of 0.45...

  8. 40 CFR 60.262 - Standard for particulate matter.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Standard for particulate matter. 60.262... Production Facilities § 60.262 Standard for particulate matter. (a) On and after the date on which the... furnace any gases which: (1) Exit from a control device and contain particulate matter in excess of 0.45...

  9. 40 CFR 60.262 - Standard for particulate matter.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Standard for particulate matter. 60.262... Production Facilities § 60.262 Standard for particulate matter. (a) On and after the date on which the... furnace any gases which: (1) Exit from a control device and contain particulate matter in excess of 0.45...

  10. 45 CFR 262.6 - What happens if a State does not demonstrate reasonable cause?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... reasonable cause? 262.6 Section 262.6 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN... cause? (a) A State may accept the penalty or enter into a corrective compliance plan that will correct...

  11. 36 CFR 262.1 - Rewards in connection with fire or property prosecutions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fire or property prosecutions. 262.1 Section 262.1 Parks, Forests, and Public Property FOREST SERVICE... connection with fire or property prosecutions. (a) Hereafter, provided Congress shall make the necessary... of willfully or maliciously setting on fire, or causing to be set on fire, any timber, underbrush, or...

  12. 36 CFR 262.1 - Rewards in connection with fire or property prosecutions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fire or property prosecutions. 262.1 Section 262.1 Parks, Forests, and Public Property FOREST SERVICE... connection with fire or property prosecutions. (a) Hereafter, provided Congress shall make the necessary... of willfully or maliciously setting on fire, or causing to be set on fire, any timber, underbrush, or...

  13. 36 CFR 262.1 - Rewards in connection with fire or property prosecutions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... fire or property prosecutions. 262.1 Section 262.1 Parks, Forests, and Public Property FOREST SERVICE... connection with fire or property prosecutions. (a) Hereafter, provided Congress shall make the necessary... of willfully or maliciously setting on fire, or causing to be set on fire, any timber, underbrush, or...

  14. 36 CFR 262.1 - Rewards in connection with fire or property prosecutions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fire or property prosecutions. 262.1 Section 262.1 Parks, Forests, and Public Property FOREST SERVICE... connection with fire or property prosecutions. (a) Hereafter, provided Congress shall make the necessary... of willfully or maliciously setting on fire, or causing to be set on fire, any timber, underbrush, or...

  15. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Impounding of dogs. 262.11... ENFORCEMENT SUPPORT ACTIVITIES Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National Forest System, which has been closed to dogs running at large, may be...

  16. 37 CFR 262.8 - Unclaimed funds.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Unclaimed funds. 262.8... TRANSMISSIONS, NEW SUBSCRIPTION SERVICES AND THE MAKING OF EPHEMERAL REPRODUCTIONS § 262.8 Unclaimed funds. If a... apply the unclaimed funds to offset any costs deductible under 17 U.S.C. 114(g)(3). The foregoing shall...

  17. 37 CFR 262.8 - Unclaimed funds.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Unclaimed funds. 262.8... TRANSMISSIONS, NEW SUBSCRIPTION SERVICES AND THE MAKING OF EPHEMERAL REPRODUCTIONS § 262.8 Unclaimed funds. If a... apply the unclaimed funds to offset any costs deductible under 17 U.S.C. 114(g)(3). The foregoing shall...

  18. The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine 262 and is essential for maintaining plasma membrane sphingomyelin levels.

    PubMed

    van Tiel, Claudia M; Westerman, Jan; Paasman, Marten A; Hoebens, Martha M; Wirtz, Karel W A; Snoek, Gerry T

    2002-06-21

    Recombinant mouse phosphatidylinositol transfer protein (PI-TP)beta is a substrate for protein kinase C (PKC)-dependent phosphorylation in vitro. Based on site-directed mutagenesis and two-dimensional tryptic peptide mapping, Ser(262) was identified as the major site of phosphorylation and Ser(165) as a minor phosphorylation site. The phospholipid transfer activities of wild-type PI-TP beta and PI-TP beta(S262A) were identical, whereas PI-TP beta(S165A) was completely inactive. PKC-dependent phosphorylation of Ser(262) also had no effect on the transfer activity of PI-TP beta. To investigate the role of Ser(262) in the functioning of PI-TP beta, wtPI-TP beta and PI-TP beta(S262A) were overexpressed in NIH3T3 fibroblast cells. Two-dimensional PAGE analysis of cell lysates was used to separate PI-TP beta from its phosphorylated form. After Western blotting, wtPI-TP beta was found to be 85% phosphorylated, whereas PI-TP beta(S262A) was not phosphorylated. In the presence of the PKC inhibitor GF 109203X, the phosphorylated form of wtPI-TP beta was strongly reduced. Immunolocalization showed that wtPI-TP beta was predominantly associated with the Golgi membranes. In the presence of the PKC inhibitor, wtPI-TP beta was distributed throughout the cell similar to what was observed for PI-TP beta(S262A). In contrast to wtPI-TP beta overexpressors, cells overexpressing PI-TP beta(S262A) were unable to rapidly replenish sphingomyelin in the plasma membrane upon degradation by sphingomyelinase. This implies that PKC-dependent association with the Golgi complex is a prerequisite for PI-TP beta to express its effect on sphingomyelin metabolism.

  19. 42 CFR 2.62 - Order not applicable to records disclosed without consent to researchers, auditors and evaluators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Order not applicable to records disclosed without consent to researchers, auditors and evaluators. 2.62 Section 2.62 Public Health PUBLIC HEALTH SERVICE... without consent to researchers, auditors and evaluators. A court order under these regulations may not...

  20. 7 CFR 1924.262 - Handling complaints involving dwellings constructed by the self-help method.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... by the self-help method. 1924.262 Section 1924.262 Agriculture Regulations of the Department of... constructed by the self-help method. When a borrower whose dwelling was constructed by the self-help method... the guidance of the self-help group. Defects which are determined to be the responsibility of a...

  1. 7 CFR 1924.262 - Handling complaints involving dwellings constructed by the self-help method.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... by the self-help method. 1924.262 Section 1924.262 Agriculture Regulations of the Department of... constructed by the self-help method. When a borrower whose dwelling was constructed by the self-help method... the guidance of the self-help group. Defects which are determined to be the responsibility of a...

  2. 42 CFR 2.62 - Order not applicable to records disclosed without consent to researchers, auditors and evaluators.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Order not applicable to records disclosed without consent to researchers, auditors and evaluators. 2.62 Section 2.62 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT...

  3. 42 CFR 2.62 - Order not applicable to records disclosed without consent to researchers, auditors and evaluators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Order not applicable to records disclosed without consent to researchers, auditors and evaluators. 2.62 Section 2.62 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT...

  4. 42 CFR 2.62 - Order not applicable to records disclosed without consent to researchers, auditors and evaluators.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Order not applicable to records disclosed without consent to researchers, auditors and evaluators. 2.62 Section 2.62 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT...

  5. 42 CFR 2.62 - Order not applicable to records disclosed without consent to researchers, auditors and evaluators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Order not applicable to records disclosed without consent to researchers, auditors and evaluators. 2.62 Section 2.62 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT...

  6. 40 CFR 262.206 - Labeling and management standards for containers of unwanted material in the laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Labeling and management standards for containers of unwanted material in the laboratory. 262.206 Section 262.206 Protection of Environment... the laboratory to assure safe storage of the unwanted material, to prevent leaks, spills, emissions to...

  7. 47 CFR 25.262 - Licensing and domestic coordination requirements for 17/24 GHz BSS space stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirements for 17/24 GHz BSS space stations. 25.262 Section 25.262 Telecommunication FEDERAL COMMUNICATIONS... Licensing and domestic coordination requirements for 17/24 GHz BSS space stations. (a) Except as described in paragraphs (b), (c) or (e) of this section, applicants seeking to operate a space station in the...

  8. 47 CFR 25.262 - Licensing and domestic coordination requirements for 17/24 GHz BSS space stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirements for 17/24 GHz BSS space stations. 25.262 Section 25.262 Telecommunication FEDERAL COMMUNICATIONS... Licensing and domestic coordination requirements for 17/24 GHz BSS space stations. (a) Except as described in paragraphs (b), (c) or (e) of this section, applicants seeking to operate a space station in the...

  9. 47 CFR 25.262 - Licensing and domestic coordination requirements for 17/24 GHz BSS space stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirements for 17/24 GHz BSS space stations. 25.262 Section 25.262 Telecommunication FEDERAL COMMUNICATIONS... Licensing and domestic coordination requirements for 17/24 GHz BSS space stations. (a) Except as described in paragraphs (b), (c) or (e) of this section, applicants seeking to operate a space station in the...

  10. 47 CFR 25.262 - Licensing and domestic coordination requirements for 17/24 GHz BSS space stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... requirements for 17/24 GHz BSS space stations. 25.262 Section 25.262 Telecommunication FEDERAL COMMUNICATIONS... Licensing and domestic coordination requirements for 17/24 GHz BSS space stations. (a) Except as described in paragraphs (b), (c) or (e) of this section, applicants seeking to operate a space station in the...

  11. 43 CFR 30.262 - When may a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false When may a tribe exercise its statutory option to purchase? 30.262 Section 30.262 Public Lands: Interior Office of the Secretary of the Interior... a tribe exercise its statutory option to purchase? (a) A tribe may exercise its statutory option to...

  12. 43 CFR 30.262 - When may a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false When may a tribe exercise its statutory option to purchase? 30.262 Section 30.262 Public Lands: Interior Office of the Secretary of the Interior... a tribe exercise its statutory option to purchase? (a) A tribe may exercise its statutory option to...

  13. 43 CFR 30.262 - When may a tribe exercise its statutory option to purchase?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true When may a tribe exercise its statutory option to purchase? 30.262 Section 30.262 Public Lands: Interior Office of the Secretary of the Interior... a tribe exercise its statutory option to purchase? (a) A tribe may exercise its statutory option to...

  14. Multiple Model Demand Forecasting Compared to Air Force Logistics Command D062 Performance.

    DTIC Science & Technology

    1980-06-01

    SRI" 1002. 930. 53.4. 46 . 074 . 119. 01. 93. 249. 224.4 METHOD $1L 4 1 2 6 4 3 2 5 FOCUS FOIC 860. 262 . 049. 9133. 966. 931. 6?. 498. 662. 21.2 -13.9...5001. 5124. 426. 1192.0 150.0 SMITH II 4018. 4640 . 3620. 9650. 9587. 8582. 965. 3937. 2468. 2486.7 2363.7 TREND 3786. 3842. 1584. 2760. 4518. 4638...FORECASTS BASD( UPON IDENTICAL DEMND DATA TEM I 30 QUARTER 2 3 4 5 6 7 0 9 RAN DIAS ACT DEMAND 262 . 269. 265. 250. 259. 262 . 265. 265. 262 . FORECAST

  15. 40 CFR 262.203 - How an eligible academic entity indicates it will be subject to the requirements of this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... indicates it will be subject to the requirements of this subpart. 262.203 Section 262.203 Protection of... entity indicates it will be subject to the requirements of this subpart. (a) An eligible academic entity... Identification Form (EPA Form 8700-12), that it is electing to be subject to the requirements of this subpart for...

  16. 40 CFR 262.203 - How an eligible academic entity indicates it will be subject to the requirements of this subpart.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... indicates it will be subject to the requirements of this subpart. 262.203 Section 262.203 Protection of... entity indicates it will be subject to the requirements of this subpart. (a) An eligible academic entity... Identification Form (EPA Form 8700-12), that it is electing to be subject to the requirements of this subpart for...

  17. 40 CFR 262.203 - How an eligible academic entity indicates it will be subject to the requirements of this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... indicates it will be subject to the requirements of this subpart. 262.203 Section 262.203 Protection of... entity indicates it will be subject to the requirements of this subpart. (a) An eligible academic entity... Identification Form (EPA Form 8700-12), that it is electing to be subject to the requirements of this subpart for...

  18. 40 CFR 262.203 - How an eligible academic entity indicates it will be subject to the requirements of this subpart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... indicates it will be subject to the requirements of this subpart. 262.203 Section 262.203 Protection of... entity indicates it will be subject to the requirements of this subpart. (a) An eligible academic entity... Identification Form (EPA Form 8700-12), that it is electing to be subject to the requirements of this subpart for...

  19. 40 CFR 262.203 - How an eligible academic entity indicates it will be subject to the requirements of this subpart.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... indicates it will be subject to the requirements of this subpart. 262.203 Section 262.203 Protection of... entity indicates it will be subject to the requirements of this subpart. (a) An eligible academic entity... Identification Form (EPA Form 8700-12), that it is electing to be subject to the requirements of this subpart for...

  20. Corrective Action Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    K. B. Campbell

    This Corrective Action Plan (CAP) provides selected corrective action alternatives and proposes the closure methodology for Corrective Action Unit (CAU) 262, Area 25 Septic Systems and Underground Discharge Point. CAU 262 is identified in the Federal Facility Agreement and Consent Order (FFACO) of 1996. Remediation of CAU 262 is required under the FFACO. CAU 262 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles [mi]) northwest of Las Vegas, Nevada. The nine Corrective Action Sites (CASs) within CAU 262 are located in the Nuclear Rocket Development Station complex. Individual CASs are locatedmore » in the vicinity of the Reactor Maintenance, Assembly, and Disassembly (R-MAD); Engine Maintenance, Assembly, and Disassembly (E-MAD); and Test Cell C compounds. CAU 262 includes the following CASs as provided in the FFACO (1996); CAS 25-02-06, Underground Storage Tank; CAS 25-04-06, Septic Systems A and B; CAS 25-04-07, Septic System; CAS 25-05-03, Leachfield; CAS 25-05-05, Leachfield; CAS 25-05-06, Leachfield; CAS 25-05-08, Radioactive Leachfield; CAS 25-05-12, Leachfield; and CAS 25-51-01, Dry Well. Figures 2, 3, and 4 show the locations of the R-MAD, the E-MAD, and the Test Cell C CASs, respectively. The facilities within CAU 262 supported nuclear rocket reactor engine testing. Activities associated with the program were performed between 1958 and 1973. However, several other projects used the facilities after 1973. A significant quantity of radioactive and sanitary waste was produced during routine operations. Most of the radioactive waste was managed by disposal in the posted leachfields. Sanitary wastes were disposed in sanitary leachfields. Septic tanks, present at sanitary leachfields (i.e., CAS 25-02-06,2504-06 [Septic Systems A and B], 25-04-07, 25-05-05,25-05-12) allowed solids to settle out of suspension prior to entering the leachfield. Posted leachfields do not contain septic tanks. All CASs located in CAU 262 are inactive or abandoned. However, some leachfields may still receive liquids from runoff during storm events. Results from the 2000-2001 site characterization activities conducted by International Technology (IT) Corporation, Las Vegas Office are documented in the Corrective Action Investigation Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada. This document is located in Appendix A of the Corrective Action Decision Document for CAU 262. Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada. (DOE/NV, 2001).« less

  1. Characterization of thiol-based redox modifications of Brassica napusSNF1-related protein kinase 2.6-2C.

    PubMed

    Ma, Tianyi; Yoo, Mi-Jeong; Zhang, Tong; Liu, Lihong; Koh, Jin; Song, Wen-Yuan; Harmon, Alice C; Sha, Wei; Chen, Sixue

    2018-04-01

    Sucrose nonfermenting 1-related protein kinase 2.6 (SnRK2.6), also known as Open Stomata 1 (OST1) in Arabidopsis thaliana , plays a pivotal role in abscisic acid (ABA)-mediated stomatal closure. Four SnRK2.6 paralogs were identified in the Brassica napus genome in our previous work. Here we studied one of the paralogs, BnSnRK2.6-2C , which was transcriptionally induced by ABA in guard cells. Recombinant BnSnRK2.6-2C exhibited autophosphorylation activity and its phosphorylation sites were mapped. The autophosphorylation activity was inhibited by S-nitrosoglutathione (GSNO) and by oxidized glutathione (GSSG), and the inhibition was reversed by reductants. Using monobromobimane (mBBr) labeling, we demonstrated a dose-dependent modification of BnSnRK2.6-2C by GSNO. Furthermore, mass spectrometry analysis revealed previously uncharacterized thiol-based modifications including glutathionylation and sulfonic acid formation. Of the six cysteine residues in BnSnRK2.6-2C, C159 was found to have different types of thiol modifications, suggesting its high redox sensitivity and versatility. In addition, mBBr labeling on tyrosine residues was identified. Collectively, these data provide detailed biochemical characterization of redox-induced modifications and changes of the BnSnRK2.6-2C activity.

  2. Association of CAT-262C/T with the concentration of catalase in seminal plasma and the risk for male infertility in Algeria.

    PubMed

    Bousnane, Nour El Houda; May, Sadiq; Yahia, Mouloud; Abu Alhaija, Abed Alkarem

    2017-10-01

    Catalase (CAT) plays a central role in the protection of different cell types against the deleterious effects of hydrogen peroxide. In human, CAT is implicated in many physiological and pathological conditions including idiopathic male infertility. In this study we examined the association between CAT levels in seminal plasma with different sperm parameters and with CAT-262 C/T polymorphism and their risk for idiopathic male infertility in Algeria. Semen and blood samples were obtained from 111 infertile males and 104 fertile controls from the region of Eastern Algeria following informed consent. Standard semen parameters, DNA integrity, and CAT concentration in seminal plasma were evaluated. CAT-262C/T genotypes were screened using allele specific PCR. Seminal CAT activity was significantly different (p<0.0001) between infertile males and controls, it was also markedly decreased in oligo-astheno-teratozoospermia (p<0.0001), azoospermia (p<0.0001), and normozoospermia (p=0.045) subgroups compared to controls. Positive correlations between CAT activity and semen parameters (volume, motility, concentration, and morphology) were detected, but not with sperm DNA integrity. There was no direct association between CAT-262C/T polymorphism and general male infertility. However, the results presented in this study showed that CAT activity is remarkably associated with the CAT-262T allele (p=0.001) and the different CAT-262C/T genotypes. This study highlighted the major differences in the seminal plasma CAT content between infertile and fertile males and the differences of CAT concentration between different CAT-262C/T genotypes carriers.

  3. Single and double acceptor-levels of a carbon-hydrogen defect in n-type silicon

    NASA Astrophysics Data System (ADS)

    Stübner, R.; Scheffler, L.; Kolkovsky, Vl.; Weber, J.

    2016-05-01

    In the present study, we discuss the origin of two dominant deep levels (E42 and E262) observed in n-type Si, which is subjected to hydrogenation by wet chemical etching or a dc H-plasma treatment. Their activation enthalpies determined from Laplace deep level transient spectroscopy measurements are EC-0.06 eV (E42) and EC-0.51 eV (E262). The similar annealing behavior and identical depth profiles of E42 and E262 correlate them with two different charge states of the same defect. E262 is attributed to a single acceptor state due to the absence of the Poole-Frenkel effect and the lack of a capture barrier for electrons. The emission rate of E42 shows a characteristic enhancement with the electric field, which is consistent with the assignment to a double acceptor state. In samples with different carbon and hydrogen content, the depth profiles of E262 can be explained by a defect with one H-atom and one C-atom. From a comparison with earlier calculations [Andersen et al., Phys. Rev. B 66, 235205 (2002)], we attribute E42 to the double acceptor and E262 to the single acceptor state of the CH1AB configuration, where one H atom is directly bound to carbon in the anti-bonding position.

  4. Single and double acceptor-levels of a carbon-hydrogen defect in n-type silicon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stübner, R.; Scheffler, L.; Kolkovsky, Vl., E-mail: kolkov@ifpan.edu.pl

    In the present study, we discuss the origin of two dominant deep levels (E42 and E262) observed in n-type Si, which is subjected to hydrogenation by wet chemical etching or a dc H-plasma treatment. Their activation enthalpies determined from Laplace deep level transient spectroscopy measurements are E{sub C}-0.06 eV (E42) and E{sub C}-0.51 eV (E262). The similar annealing behavior and identical depth profiles of E42 and E262 correlate them with two different charge states of the same defect. E262 is attributed to a single acceptor state due to the absence of the Poole-Frenkel effect and the lack of a capture barrier formore » electrons. The emission rate of E42 shows a characteristic enhancement with the electric field, which is consistent with the assignment to a double acceptor state. In samples with different carbon and hydrogen content, the depth profiles of E262 can be explained by a defect with one H-atom and one C-atom. From a comparison with earlier calculations [Andersen et al., Phys. Rev. B 66, 235205 (2002)], we attribute E42 to the double acceptor and E262 to the single acceptor state of the CH{sub 1AB} configuration, where one H atom is directly bound to carbon in the anti-bonding position.« less

  5. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli

    PubMed Central

    Nadif, Rachel; Mintz, Margaret; Jedlicka, Anne; Bertrand, Jean-Pierre; Kleeberger, Steven R.; Kauffmann, Francine

    2005-01-01

    We tested the hypotheses that catalase activity is modified by CAT single nucleotide polymorphisms (SNPs) (–262;–844), and by their interactions with oxidant exposures (coal dusts, smoking), lymphotoxin alpha (LTA, NcoI) and tumor necrosis factor (TNF, -308) in 196 miners. Erythrocyte catalase, superoxide dismutase, and glutathione peroxidase activities were measured. The CAT –262 SNP was related to lower catalase activity (104, 87 and 72 k/g hemoglobin for CC, CT and TT respectively, p<0.0001). Regardless of CAT SNPs, the LTA NcoI but not the TNF –308 SNP was associated with catalase activity (p=0.04 and p=0.8). CAT –262 T carriers were less frequent in highly exposed miners (OR=0.39 [0.20 – 0.78], p=0.007). In CAT –262 T carriers only, catalase activity decreased with high dust exposure (p=0.01). Haplotype analyses (combined CAT SNPs) confirm these results. Results show that CAT –262 and LTA NcoI SNPs, and interaction with coal dust exposure, influenced catalase activity. PMID:16298864

  6. 40 CFR 262.108 - When will this subpart expire?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project-Laboratory Environmental Management Standard § 262.108 When will this subpart expire? This subpart will...

  7. 40 CFR 262.55 - Exception reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports... Protection Agency, 1200 Pennsylvania Avenue, NW., Washington, DC 20460, if any of the following occurs: ...

  8. 7. SOUTH ELEVATION OF BUILDING 262 (SOUTH SENTRY POST) IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. SOUTH ELEVATION OF BUILDING 262 (SOUTH SENTRY POST) IN STORAGE AREA. - Loring Air Force Base, Weapons Storage Area, Northeastern corner of base at northern end of Maine Road, Limestone, Aroostook County, ME

  9. Cost-effectiveness analysis of dose-dense versus standard intravenous chemotherapy for ovarian cancer: An economic analysis of results from the Gynecologic Oncology Group protocol 262 randomized controlled trial.

    PubMed

    Seagle, Brandon-Luke L; Shahabi, Shohreh

    2017-04-01

    To determine the cost-effectiveness of dose-dense versus standard intravenous adjuvant chemotherapy for ovarian cancer using results from the no-bevacizumab cohort of the Gynecologic Oncology Group protocol 262 (GOG-262) randomized controlled trial, which reported a smaller absolute progression-free survival (PFS) benefit than the prior Japanese trial. A three-state Markov decision model from a healthcare system perspective with a 21day cycle length and 28month time-horizon was used to calculate incremental cost-effectiveness ratio (ICER) values per progression-free life-year saved (PFLYS) using results from GOG-262. Costs of chemotherapy, complications, and surveillance were from Medicare or institutional data. PFS, discontinuation, and complication rates were from GOG-262. Time-dependent transition probabilities and within-cycle corrections were used. One-way and probabilistic sensitivity analyses were performed. The model produces standard and dose-dense cohorts with 84.3% and 68.3% progression event proportions at 28months, matching GOG-262 rates at the trial's median follow-up. With a median PFS of 10.3months after standard chemotherapy and a hazard ratio for progression of 0.62 after dose-dense therapy, the ICER for dose-dense chemotherapy is $8074.25 (95% confidence interval: $7615.97-$10,207.16) per PFLYS. ICER estimates are sensitive only to the hazard ratio estimate but do not exceed $100,000 per PFLYS. 99.8% of ICER estimates met a more stringent willingness-to-pay of $50,000 per PFLYS. The willingness-to-pay value at which there is a 90% probability of dose-dense treatment being cost-effective is $12,000 per PFLYS. Dose-dense adjuvant chemotherapy is robustly cost-effective for advanced ovarian cancer from a healthcare system perspective based on results from GOG-262. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. 40 CFR 98.262 - GHGs to report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... part (General Stationary Fuel Combustion Sources) the emissions of CO2, CH4, and N2O from each... GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.262 GHGs to report. (a) You must report CO2 process...

  11. 40 CFR 98.262 - GHGs to report.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... part (General Stationary Fuel Combustion Sources) the emissions of CO2, CH4, and N2O from each... GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.262 GHGs to report. (a) You must report CO2 process...

  12. 40 CFR 98.262 - GHGs to report.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... part (General Stationary Fuel Combustion Sources) the emissions of CO2, CH4, and N2O from each... GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.262 GHGs to report. (a) You must report CO2 process...

  13. 40 CFR 98.262 - GHGs to report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... part (General Stationary Fuel Combustion Sources) the emissions of CO2, CH4, and N2O from each... GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.262 GHGs to report. (a) You must report CO2 process...

  14. 40 CFR 98.262 - GHGs to report.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... part (General Stationary Fuel Combustion Sources) the emissions of CO2, CH4, and N2O from each... GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.262 GHGs to report. (a) You must report CO2 process...

  15. 39 CFR 262.4 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.4 Records. Recorded information, regardless of media, format, or physical characteristics...) Corporate records. Those records series that are designated by the Records Office as containing information...

  16. 39 CFR 262.4 - Records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.4 Records. Recorded information, regardless of media, format, or physical characteristics...) Corporate records. Those records series that are designated by the Records Office as containing information...

  17. 39 CFR 262.4 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.4 Records. Recorded information, regardless of media, format, or physical characteristics...) Corporate records. Those records series that are designated by the Records Office as containing information...

  18. 39 CFR 262.4 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.4 Records. Recorded information, regardless of media, format, or physical characteristics...) Corporate records. Those records series that are designated by the Records Office as containing information...

  19. 39 CFR 262.4 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.4 Records. Recorded information, regardless of media, format, or physical characteristics...) Corporate records. Those records series that are designated by the Records Office as containing information...

  20. 37 CFR 262.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 262.2 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... whole or in part, of eligible nonsubscription transmissions or noninteractive digital audio... eligible nonsubscription transmissions, or noninteractive digital audio transmissions as part of a new...

  1. 40 CFR 262.53 - Notification of intent to export.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... country (e.g., land or ocean incineration, other land disposal, ocean dumping, recycling); (vii) The name... forward an EPA Acknowledgment of Consent to the primary exporter for purposes of § 262.54(h). Where the...

  2. 40 CFR 262.53 - Notification of intent to export.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... country (e.g., land or ocean incineration, other land disposal, ocean dumping, recycling); (vii) The name... forward an EPA Acknowledgment of Consent to the primary exporter for purposes of § 262.54(h). Where the...

  3. 40 CFR 262.53 - Notification of intent to export.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... country (e.g., land or ocean incineration, other land disposal, ocean dumping, recycling); (vii) The name... forward an EPA Acknowledgment of Consent to the primary exporter for purposes of § 262.54(h). Where the...

  4. 40 CFR 262.53 - Notification of intent to export.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... country (e.g., land or ocean incineration, other land disposal, ocean dumping, recycling); (vii) The name... forward an EPA Acknowledgment of Consent to the primary exporter for purposes of § 262.54(h). Where the...

  5. 40 CFR 262.53 - Notification of intent to export.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... country (e.g., land or ocean incineration, other land disposal, ocean dumping, recycling); (vii) The name... forward an EPA Acknowledgment of Consent to the primary exporter for purposes of § 262.54(h). Where the...

  6. 40 CFR 262.83 - Notification and consent.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 262.83 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Transboundary Movements of Hazardous Waste... exporting hazardous waste destined for recovery operations subject to this subpart. Hazardous wastes subject...

  7. 262. Frank Deras Jr., Photographer June 1998 AERIAL VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    262. Frank Deras Jr., Photographer June 1998 AERIAL VIEW OF CANTILEVER TRUSS CANTILEVER ARM AND SUSPENDED SPAN, NORTH SIDE, FACING SOUTH. - San Francisco Oakland Bay Bridge, Spanning San Francisco Bay, San Francisco, San Francisco County, CA

  8. 9. DETAIL OF GUNPORT ON SOUTH ELEVATION OF BUILDING 262 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAIL OF GUNPORT ON SOUTH ELEVATION OF BUILDING 262 (SOUTH SENTRY POST) IN STORAGE AREA. - Loring Air Force Base, Weapons Storage Area, Northeastern corner of base at northern end of Maine Road, Limestone, Aroostook County, ME

  9. Publications - GMC 262 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    DGGS GMC 262 Publication Details Title: Map location and geological logs of core for 7 1991 diamond Reference Cominco American Inc., 1996, Map location and geological logs of core for 7 1991 diamond drill

  10. 49 CFR 262.15 - Environmental assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FRA to approve a project for physical construction. FRA's “Procedures for Considering Environmental... and historic preservation review requirements. (b) States have two options for proceeding with environmental/historic preservation reviews. A State may file an application under subsection § 262.11 seeking...

  11. 40 CFR 262.213 - Laboratory clean-outs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... waste or more than 100 kg/month of hazardous waste (i.e., the conditionally exempt small quantity... 262.213 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative Requirements for Hazardous Waste...

  12. 40 CFR 262.213 - Laboratory clean-outs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... waste or more than 100 kg/month of hazardous waste (i.e., the conditionally exempt small quantity... 262.213 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative Requirements for Hazardous Waste...

  13. [Effects of nitrogen application levels on yield and active composition content of Desmodium styracifolium].

    PubMed

    Zhou, Jiamin; Yin, Xiaohong; Chen, Chaojun; Huang, Min; Peng, Fuyuan; Zhu, Xiaoqi

    2010-06-01

    To find out the optimal nitrogen application level of Desmodium styracifolium. A field experiment using randomized block design was carried out to study the effects of 5 nitrogen application levels (150, 187.5, 225.0, 262.5 and 300.0 kg x hm(-2)) on yield and active component content of D. styracifolium. Nitrogen application could increase the yield and contents of polysaccharide, total flavonoides and total saponins of D. styracifolium. However, the enhancing extent of the active component content and the yield were not always significant with the increase of nitrogen level. In which, the yield were not significantly different among the nitrogen application levels of 225.0, 262.5, 300.0 kg x hm(-2) the polysaccharide content was no significantly difference among the nitrogen application levels of 225.0, 262. 5 and 300.0 kg x hm(-2), the total flavonoides content under the nitrogen level of 300.0 kg x hm(-2) was significantly lower than that of 150.0 kg hm(-2) (P < 0.01), and the total saponins content under the nitrogen level of 300.0 kg x hm(-2) was no significant difference compared with that of 262.5 kg x hm(-2). The optimal nitrogen application level of D. styracifolium was 225.0-262.5 kg x hm(-2).

  14. 38 CFR 3.262 - Evaluation of income.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate § 3.262... dependency, or in determining the rate of dependency and indemnity compensation payable to the parent. This... dependency and indemnity compensation. (d) Charitable donations. Charitable donations from public or private...

  15. 38 CFR 3.262 - Evaluation of income.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate § 3.262... dependency, or in determining the rate of dependency and indemnity compensation payable to the parent. This... dependency and indemnity compensation. (d) Charitable donations. Charitable donations from public or private...

  16. 38 CFR 3.262 - Evaluation of income.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate § 3.262... dependency, or in determining the rate of dependency and indemnity compensation payable to the parent. This... dependency and indemnity compensation. (d) Charitable donations. Charitable donations from public or private...

  17. 38 CFR 3.262 - Evaluation of income.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate § 3.262... dependency, or in determining the rate of dependency and indemnity compensation payable to the parent. This... dependency and indemnity compensation. (d) Charitable donations. Charitable donations from public or private...

  18. 38 CFR 3.262 - Evaluation of income.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate § 3.262... dependency, or in determining the rate of dependency and indemnity compensation payable to the parent. This... dependency and indemnity compensation. (d) Charitable donations. Charitable donations from public or private...

  19. 37 CFR 262.5 - Confidential information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 262... Confidential information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including the amount of royalty payments...

  20. 37 CFR 262.5 - Confidential information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 262... information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including the amount of royalty payments, and any...

  1. 40 CFR 262.57 - Recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.57 Recordkeeping. (a) For all... at least three years from the date the hazardous waste was accepted by the initial transporter; (2...

  2. 37 CFR 262.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 262.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION... eligible nonsubscription transmissions or noninteractive digital audio transmissions as part of a new... noninteractive digital audio transmissions as part of a new subscription service (as defined in 17 U.S.C. 114(j...

  3. 37 CFR 262.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 262.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION... eligible nonsubscription transmissions or noninteractive digital audio transmissions as part of a new... noninteractive digital audio transmissions as part of a new subscription service (as defined in 17 U.S.C. 114(j...

  4. 40 CFR 262.214 - Laboratory management plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain a... a site-specific document that describes how the eligible academic entity will manage unwanted...

  5. 40 CFR 262.82 - General conditions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., other Federal environmental statutes (e.g., the Toxic Substances Control Act) restrict certain waste... to EPA in accordance with § 262.87(b). (e) Duty to return wastes subject to the Amber control....82 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  6. 40 CFR 262.82 - General conditions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (e.g., the Toxic Substances Control Act) restrict certain waste imports or exports. Such restrictions... to EPA in accordance with § 262.87(b). (e) Duty to return wastes subject to the Amber control....82 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  7. 40 CFR 262.214 - Laboratory management plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain a... a site-specific document that describes how the eligible academic entity will manage unwanted...

  8. 40 CFR 262.214 - Laboratory management plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain a... a site-specific document that describes how the eligible academic entity will manage unwanted...

  9. 40 CFR 262.101 - What is in this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project-Laboratory Environmental Management Standard § 262.101 What is in this subpart? This subpart provides a framework for a new management system for wastes that are generated in University laboratories. This...

  10. 40 CFR 262.51 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.51 Definitions. In addition to... waste will be sent. EPA Acknowledgement of Consent means the cable sent to EPA from the U.S. Embassy in...

  11. 12 CFR 26.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... exclusively to the business of retail merchandising or manufacturing; (ii) A person whose management functions... Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 26.2... section 202, shares held by an individual include shares held by members of his or her immediate family...

  12. 18 CFR 284.262 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF ENERGY OTHER REGULATIONS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES CERTAIN SALES AND TRANSPORTATION OF NATURAL GAS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES Emergency Natural Gas Sale, Transportation, and Exchange Transactions § 284.262 Definitions. For purposes of...

  13. 8. CONTEXT VIEW LOOKING NORTHWEST OF BUILDING 262 (SOUTH SENTRY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. CONTEXT VIEW LOOKING NORTHWEST OF BUILDING 262 (SOUTH SENTRY POST) IN STORAGE AREA WITH BUILDING 260 (STORAGE STRUCTURE A) AT LEFT. - Loring Air Force Base, Weapons Storage Area, Northeastern corner of base at northern end of Maine Road, Limestone, Aroostook County, ME

  14. 40 CFR 262.205 - Summary of the requirements of this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Eligible Academic Entities § 262.205 Summary of the requirements of this subpart. An eligible academic... laboratories comply with the provisions of this subpart and the eligible academic entity has a Laboratory... academic entity will comply with the requirements of this subpart. ...

  15. 40 CFR 262.205 - Summary of the requirements of this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Eligible Academic Entities § 262.205 Summary of the requirements of this subpart. An eligible academic... laboratories comply with the provisions of this subpart and the eligible academic entity has a Laboratory... academic entity will comply with the requirements of this subpart. ...

  16. 40 CFR 262.205 - Summary of the requirements of this subpart.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Eligible Academic Entities § 262.205 Summary of the requirements of this subpart. An eligible academic... laboratories comply with the provisions of this subpart and the eligible academic entity has a Laboratory... academic entity will comply with the requirements of this subpart. ...

  17. 40 CFR 262.207 - Training.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.207 Training. An eligible academic entity must provide training to all individuals working in a laboratory at the eligible academic entity, as follows: (a) Training for laboratory workers and students must be commensurate with...

  18. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  19. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  20. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  1. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  2. 40 CFR 262.56 - Annual reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.56 Annual reports. (a) Primary...), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460. Hand-delivered reports... St. and Pennsylvania Ave., NW., Washington, DC 20004. [51 FR 28682, Aug. 8, 1986, as amended at 56 FR...

  3. [Acute myeloid leukemia with monosomy 7 and inv(3)(q21q26.2) complicated with central diabetes insipidus].

    PubMed

    Nanno, Satoru; Hagihara, Kiyoyuki; Sakabe, Manami; Okamura, Hiroshi; Inaba, Akiko; Nagata, Yuki; Nishimoto, Mitsutaka; Koh, Hideo; Nakao, Yoshitaka; Nakane, Takahiko; Nakamae, Hirohisa; Shimono, Taro; Hino, Masayuki

    2013-04-01

    A 20-year-old female presented with thirst, polyposia, and polyuria and was referred to our hospital because of leukocytosis and anemia. Bone marrow aspiration revealed 66.8% myeloperoxidase-positive blasts and trilineage myelodysplasia. The karyotype was 45, XX, inv(3)(q21q26.2), -7[19]. Therefore, a diagnosis of AML with inv(3)(q21q26.2) complicated by -7 was made. Moreover, hyposthenuria and a low anti-diuretic hormone (ADH) level were observed. Although cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) revealed the absence of hyperintensity in the neurohypophysis in T1-weighted images. Therefore, she was also diagnosed with diabetes insipidus. After she was administered a desmopressin nasal spray, the volume of urine produced decreased. Following treatment with second induction therapy containing high-dose cytarabine for AML, she achieved complete remission in the bone marrow. Moreover, when the abnormality on MRI and the volume of urine were normalized, she discontinued desmopressin. Although diabetes insipidus is a rare complication of AML, the majority of AML patients who have diabetes insipidus have the abnormal karyotypes with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7. Further study is required to clarify the pathogenesis and develop a strategy for the treatment of this category of AML.

  4. Comparative analysis of root transcriptome profiles between drought-tolerant and susceptible wheat genotypes in response to water stress.

    PubMed

    Hu, Ling; Xie, Yan; Fan, Shoujin; Wang, Zongshuai; Wang, Fahong; Zhang, Bin; Li, Haosheng; Song, Jie; Kong, Lingan

    2018-07-01

    Water deficit is one of the major factors limiting crop productivity worldwide. Plant roots play a key role in uptaking water, perceiving and transducing of water deficit signals to shoot. Although the mechanisms of drought-tolerance have been reported recently, the transcriptional regulatory network of wheat root response to water stress has not been fully understood. In this study, drought-tolerant cultivar JM-262 and susceptible cultivar LM-2 are planted to characterize the root transcriptional changes and physiological responses to water deficit. A total of 8197 drought tolerance-associated differentially expressed genes (DEGs) are identified, these genes are mainly mapped to carbon metabolism, flavonoid biosynthesis, and phytohormone signal transduction. The number and expression level of DEGs involved in antioxidative and antiosmotic stresses are more enhanced in JM-262 under water stress. Furthermore, we find the DEGs related to root development are much more induced in JM-262 in phytohormone signal transduction and carbon metabolism pathway. In conclusion, JM-262 may alleviate the damage of drought by producing more osmoprotectants, ROS scavengers, biomass and energy. Interestingly, hormone signaling and cross-talk probably play an important role in promoting JM-262 greater root systems to take up more water, higher capabilities to induce more drought-related DEGs and higher resisitance to oxidative stresse. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. 36 CFR 262.5 - Disposal of purchased property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Disposal of purchased... LAW ENFORCEMENT SUPPORT ACTIVITIES Rewards and Payments § 262.5 Disposal of purchased property. All evidence purchased under the authority of this subpart shall be maintained in accordance with all laws...

  6. 40 CFR 262.24 - Use of the electronic manifest.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.24 Use of the electronic... originated that all waste handlers named on the manifest participate in the electronic manifest system. (d... is unavailable. If a generator has prepared an electronic manifest for a hazardous waste shipment...

  7. 40 CFR 262.82 - General conditions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Recovery within the OECD § 262.82 General conditions. (a) Scope. The level of control for exports and...), COTIF (1985), and RID (1985). (3) Any transit of waste through a non-OECD member country must be... consent is received from all relevant OECD importing and transit countries. (2) Re-export of waste subject...

  8. 40 CFR 262.102 - What special definitions are included in this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Laboratories XL Project-Laboratory Environmental Management Standard § 262.102 What special definitions are... Laboratory Waste means a laboratory waste, defined in the Environmental Management Plan as posing significant... Management Plan (EMP) means a written program developed and implemented by the university which sets forth...

  9. 40 CFR 262.104 - What are the minimum performance criteria?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... XL Project-Laboratory Environmental Management Standard § 262.104 What are the minimum performance... container management. (f) The management of laboratory waste must not result in the release of hazardous... waste management program approved under 40 CFR part 271) if it is determined in the laboratory by the...

  10. 7 CFR 1951.262 - Farm Credit Programs-graduation of borrowers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Farm Credit Programs-graduation of borrowers. 1951... Credit Needs and Graduation of Borrowers § 1951.262 Farm Credit Programs—graduation of borrowers. (a)-(d) [Reserved] (e) Graduation candidates. Borrowers who are classified “commercial” or “standard” are graduation...

  11. 7 CFR 1951.262 - Farm Credit Programs-graduation of borrowers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false Farm Credit Programs-graduation of borrowers. 1951... Credit Needs and Graduation of Borrowers § 1951.262 Farm Credit Programs—graduation of borrowers. (a)-(d) [Reserved] (e) Graduation candidates. Borrowers who are classified “commercial” or “standard” are graduation...

  12. 7 CFR 1951.262 - Farm Credit Programs-graduation of borrowers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 14 2013-01-01 2013-01-01 false Farm Credit Programs-graduation of borrowers. 1951... Credit Needs and Graduation of Borrowers § 1951.262 Farm Credit Programs—graduation of borrowers. (a)-(d) [Reserved] (e) Graduation candidates. Borrowers who are classified “commercial” or “standard” are graduation...

  13. 7 CFR 1951.262 - Farm Credit Programs-graduation of borrowers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false Farm Credit Programs-graduation of borrowers. 1951... Credit Needs and Graduation of Borrowers § 1951.262 Farm Credit Programs—graduation of borrowers. (a)-(d) [Reserved] (e) Graduation candidates. Borrowers who are classified “commercial” or “standard” are graduation...

  14. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  15. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  16. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  17. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  18. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  19. 42 CFR 422.262 - Beneficiary premiums.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and Plan Approval § 422.262 Beneficiary premiums. (a) Determination of MA monthly basic beneficiary premium. (1) For an MA plan with an unadjusted statutory non-drug bid amount that is less than the relevant unadjusted non-drug benchmark amount, the basic beneficiary premium is zero. (2) For an MA plan...

  20. 42 CFR 422.262 - Beneficiary premiums.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Information and Plan Approval § 422.262 Beneficiary premiums. (a) Determination of MA monthly basic beneficiary premium. (1) For an MA plan with an unadjusted statutory non-drug bid amount that is less than the relevant unadjusted non-drug benchmark amount, the basic beneficiary premium is zero. (2) For an MA plan...

  1. 42 CFR 422.262 - Beneficiary premiums.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Information and Plan Approval § 422.262 Beneficiary premiums. (a) Determination of MA monthly basic beneficiary premium. (1) For an MA plan with an unadjusted statutory non-drug bid amount that is less than the relevant unadjusted non-drug benchmark amount, the basic beneficiary premium is zero. (2) For an MA plan...

  2. 42 CFR 422.262 - Beneficiary premiums.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and Plan Approval § 422.262 Beneficiary premiums. (a) Determination of MA monthly basic beneficiary premium. (1) For an MA plan with an unadjusted statutory non-drug bid amount that is less than the relevant unadjusted non-drug benchmark amount, the basic beneficiary premium is zero. (2) For an MA plan...

  3. 42 CFR 422.262 - Beneficiary premiums.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Information and Plan Approval § 422.262 Beneficiary premiums. (a) Determination of MA monthly basic beneficiary premium. (1) For an MA plan with an unadjusted statutory non-drug bid amount that is less than the relevant unadjusted non-drug benchmark amount, the basic beneficiary premium is zero. (2) For an MA plan...

  4. 40 CFR 262.82 - General conditions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Recovery Within the OECD § 262.82 General conditions. (a) Scope. The level of control for exports and... country of import. (B) For U.S. imports, the U.S. recovery facility/importer and the United States shall... procedures, provided the composition of this mixture does not impair its environmentally sound recovery. Note...

  5. 40 CFR 262.87 - Reporting and recordkeeping.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... movements subject to this subpart, persons (e.g., exporters, recognized traders) who meet the definition of...(s) and applicable waste code(s) from the appropriate OECD waste list incorporated by reference in... imprisonment. (b) Exception reports. Any person who meets the definition of primary exporter in § 262.51 or who...

  6. 40 CFR 262.87 - Reporting and recordkeeping.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... movements subject to this subpart, persons (e.g., exporters, recognized traders) who meet the definition of...(s) and applicable waste code(s) from the appropriate OECD waste list incorporated by reference in... imprisonment. (b) Exception reports. Any person who meets the definition of primary exporter in § 262.51 or who...

  7. 40 CFR 262.87 - Reporting and recordkeeping.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... movements subject to this subpart, persons (e.g., exporters, recognized traders) who meet the definition of...(s) and applicable waste code(s) from the appropriate OECD waste list incorporated by reference in... imprisonment. (b) Exception reports. Any person who meets the definition of primary exporter in § 262.51 or who...

  8. 40 CFR 262.87 - Reporting and recordkeeping.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... movements subject to this subpart, persons (e.g., exporters, recognized traders) who meet the definition of...(s) and applicable waste code(s) from the appropriate OECD waste list incorporated by reference in... imprisonment. (b) Exception reports. Any person who meets the definition of primary exporter in § 262.51 or who...

  9. 28 CFR 26.2 - Proposed Judgment and Order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of a lethal substance or substances in a quantity sufficient to cause death; (3) The sentence shall... 26.2 Judicial Administration DEPARTMENT OF JUSTICE DEATH SENTENCES PROCEDURES Implementation of Death... (4) The prisoner under sentence of death shall be committed to the custody of the Attorney General or...

  10. 20 CFR 632.262 - Termination date for the summer program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Termination date for the summer program. 632... INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.262 Termination date for the summer program. Participants may not be enrolled in the summer...

  11. 20 CFR 632.262 - Termination date for the summer program.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Termination date for the summer program. 632... INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.262 Termination date for the summer program. Participants may not be enrolled in the summer...

  12. 20 CFR 632.262 - Termination date for the summer program.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Termination date for the summer program. 632... INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.262 Termination date for the summer program. Participants may not be enrolled in the summer...

  13. 76 FR 9077 - Proposed Collection; Comment Request for Regulation Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... soliciting comments concerning an existing final regulation, PS-262-82 (T.D. 8600), Definition of an S... assured of consideration. ADDRESSES: Direct all written comments to Yvette B. Lawrence, Internal Revenue...: Definition of an S Corporation. OMB Number: 1545-0731. Regulation Project Number: PS-262-82 (T.D. 8600...

  14. Anxiety in Patients with Cardiac Disease

    DTIC Science & Technology

    2005-01-01

    results from the Medical Outcomes Study. JAMA. 1989;262:907-913. 28. Juenger J, Schellberg D, Kraemer S, et al. Health related quality of life in...well-being of patients with chronic conditions: results from the Medical Outcomes Study. JAMA. 1989;262:907-913. 28. Juenger J, Schellberg D, Kraemer S

  15. 40 CFR 262.208 - Removing containers of unwanted material from the laboratory.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Laboratories Owned by Eligible Academic Entities § 262.208 Removing containers of unwanted material from the laboratory. (a) Removing containers of unwanted material on a regular schedule. An eligible academic entity... months of each container's accumulation start date. (b) The eligible academic entity must specify in Part...

  16. 40 CFR 262.208 - Removing containers of unwanted material from the laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Laboratories Owned by Eligible Academic Entities § 262.208 Removing containers of unwanted material from the laboratory. (a) Removing containers of unwanted material on a regular schedule. An eligible academic entity... months of each container's accumulation start date. (b) The eligible academic entity must specify in Part...

  17. 40 CFR 262.208 - Removing containers of unwanted material from the laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Laboratories Owned by Eligible Academic Entities § 262.208 Removing containers of unwanted material from the laboratory. (a) Removing containers of unwanted material on a regular schedule. An eligible academic entity... months of each container's accumulation start date. (b) The eligible academic entity must specify in Part...

  18. 262. Photocopy of drawing (1976 piping drawing by StearnsRoger Incorporated) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    262. Photocopy of drawing (1976 piping drawing by Stearns-Roger Incorporated) GLOBAL POSITIONING SYSTEM MODIFICATIONS, PAYLOAD PRESSURIZATION UNIT HIGH PRESSURE GASEOUS NITROGEN AND HELIUM LINES FOR LSB, SHEET 501-P3 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  19. 29 CFR 1952.262 - Completion of developmental steps and certification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Completion of developmental steps and certification. 1952... § 1952.262 Completion of developmental steps and certification. (a) In accordance with § 1952.263(a), the... effective January 13, 1981 as having completed all developmental steps specified in the plan as approved on...

  20. 40 CFR 97.262 - Notification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Transfers § 97.262 Notification. (a) Notification of recordation. Within 5 business days of recordation of a CAIR SO2 allowance... of receipt of a CAIR SO2 allowance transfer that fails to meet the requirements of § 97.261(a), the...

  1. 50 CFR 648.262 - Accountability measures for red crab limited access vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Accountability measures for red crab... UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.262 Accountability measures for red crab limited access vessels. (a) Closure authority. NMFS shall close the EEZ to fishing...

  2. 45 CFR 262.4 - What happens if we determine that a State is subject to a penalty?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH... statute; and (4) Explain how and when the State may submit a reasonable cause justification under § 262.5..., on a reasonable interpretation of the statute; (2) Demonstrates that the State had reasonable cause...

  3. 40 CFR 262.200 - Definitions for this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) and (k) for Performance Track members) of this part (large quantity generators); or § 262.34(d)-(f) of... or research (or diagnostic purposes at a teaching hospital) and are stored and used in containers...” under this subpart. Working container means a small container (i.e., two gallons or less) that is in use...

  4. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  5. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  6. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  7. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  8. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  9. 40 CFR 262.215 - Unwanted material that is not solid or hazardous waste.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Unwanted material that is not solid or... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative... Eligible Academic Entities § 262.215 Unwanted material that is not solid or hazardous waste. (a) If an...

  10. 40 CFR 262.215 - Unwanted material that is not solid or hazardous waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Unwanted material that is not solid or... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative... Eligible Academic Entities § 262.215 Unwanted material that is not solid or hazardous waste. (a) If an...

  11. 36 CFR 262.1 - Rewards in connection with fire or property prosecutions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Rewards in connection with..., DEPARTMENT OF AGRICULTURE LAW ENFORCEMENT SUPPORT ACTIVITIES Rewards and Payments § 262.1 Rewards in... appropriation or authorize the payment thereof, the Department of Agriculture will pay the following rewards: (1...

  12. Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion.

    PubMed

    Sabet, Eliza Eskafi; Salehi, Zivar; Khodayari, Siamak; Zarafshan, Samin Sabouhi; Zahiri, Ziba

    2014-10-01

    About 10%-15% of conceptions are lost spontaneously prior to 20 weeks. Apart from the clinical problems, genetic variations have also been proposed as a susceptibility factor to miscarriage. Glutathione peroxidase 1 (GPX1) and catalase (CAT) encode two antioxidant enzymes that detoxify H2O2 and protect the cells from oxidative damage. A functional polymorphism at codon 198 of the GPX1 gene causes a C/T substitution in exon 2, which encodes for either proline or leucine (Pro198Leu). The CAT gene has a polymorphic site in the promoter region at position -262 (C-262T) which alters the expression and enzyme blood levels, leading to some pathological clinical conditions. In this study, we evaluated the association of these two polymorphisms with the risk of spontaneous abortion. Genomic DNA from 105 cases with spontaneous abortion and 90 healthy women were genotyped using allele-specific PCR (AS-PCR) and polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP). The genetic distributions for GPX1 did not differ significantly between cases and controls (p = 0.680). However, C-262T polymorphism was significantly associated with the risk of the disease (OR, 5.50; 95% CI, 1.43-21.09; p = 0.012). In conclusion, this study indicates that CAT -262T/T genotype confers less susceptibility to spontaneous abortion, while GPX1 Pro198Leu polymorphism may not be correlated with the disease.

  13. LkHα 262/263: the paradigm of multiplicity vs disk fraction in low-mass stellar systems.

    NASA Astrophysics Data System (ADS)

    Velasco, S.; Rebolo, R.; Oscoz, A.; Labadie, L.; Pérez-Garrido, A.

    2017-03-01

    The study of multiple systems and their link with the presence of discs around their components is key to understanding the evolution of low-mass pre-main sequence stars. Although there are indications that high-multiplicity systems are much more frequent among very young stars, until now, only a few of these young low-mass stellar systems have been confirmed. Here, we present high spatial resolution i band imaging of the system formed by LkHα 262 and LkHα 263, in the MBM12 cloud. It was obtained during the first commissioning period of the Adaptive Optics Lucky Imager (AOLI) at the 4.2 m William Herschel Telescope, using its Lucky Imaging mode. The multiple system LkHα 262/263 is composed of four low-mass very young M-type stars and some discs, including an edge-on disc around LkHα 263C. The AOLI data combined with previously available and newly obtained optical and infrared imaging show that the three components of LkHα 263 are co-moving, that there is orbital motion in the AB pair (0.41arcsec separation), and, remarkably, that LkHα 262-263 is a common proper motion system with a less than 1 mas/yr relative motion. According to BT-settl models the mass of each of the five components is close to 0.4 M and the age is in the range 1-2 Myr. We also give marginal evidence of a cooler companion to LkHα 262, at less than 0.15 arcsec, turning LkHα 262-263 into a five-component likely gravitationally bounded system. The presence of discs in some of the components offers an interesting opportunity to investigate the formation and evolution of discs in the early stages of multiple very low-mass systems.

  14. 25 CFR 262.4 - Activities by Indian tribes or individuals that require a permit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Activities by Indian tribes or individuals that require a... PRESERVATION PROTECTION OF ARCHAEOLOGICAL RESOURCES § 262.4 Activities by Indian tribes or individuals that require a permit. (a) No Indian tribe may, without a permit under the Act, excavate or remove...

  15. 42 CFR 422.270 - Incorrect collections of premiums and cost-sharing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Means amounts that- (A) Exceed the limits approved under § 422.262; (B) In the case of an MA private fee-for-service plan, exceed the MA monthly basic beneficiary premium or the MA monthly supplemental premium submitted under § 422.262; and (C) In the case of an MA MSA plan, exceed the MA monthly...

  16. 42 CFR 422.270 - Incorrect collections of premiums and cost-sharing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Means amounts that- (A) Exceed the limits approved under § 422.262; (B) In the case of an MA private fee-for-service plan, exceed the MA monthly basic beneficiary premium or the MA monthly supplemental premium submitted under § 422.262; and (C) In the case of an MA MSA plan, exceed the MA monthly...

  17. 42 CFR 422.270 - Incorrect collections of premiums and cost-sharing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Means amounts that- (A) Exceed the limits approved under § 422.262; (B) In the case of an MA private fee-for-service plan, exceed the MA monthly basic beneficiary premium or the MA monthly supplemental premium submitted under § 422.262; and (C) In the case of an MA MSA plan, exceed the MA monthly...

  18. 42 CFR 422.270 - Incorrect collections of premiums and cost-sharing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... that- (A) Exceed the limits approved under § 422.262; (B) In the case of an MA private fee-for-service plan, exceed the MA monthly basic beneficiary premium or the MA monthly supplemental premium submitted under § 422.262; and (C) In the case of an MA MSA plan, exceed the MA monthly beneficiary supplemental...

  19. 42 CFR 422.270 - Incorrect collections of premiums and cost-sharing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... that- (A) Exceed the limits approved under § 422.262; (B) In the case of an MA private fee-for-service plan, exceed the MA monthly basic beneficiary premium or the MA monthly supplemental premium submitted under § 422.262; and (C) In the case of an MA MSA plan, exceed the MA monthly beneficiary supplemental...

  20. 50 CFR 648.262 - Effort-control program for red crab limited access vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Effort-control program for red crab... UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.262 Effort-control program for red crab limited access vessels. (a) General. A vessel issued a limited access red crab permit...

  1. 29 CFR 779.262 - Excise taxes at the retail level.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Coverage Excise Taxes § 779.262 Excise taxes at the retail level. (a) Federal excise taxes are imposed at.... Such excise taxes are levied at the retail level on any liquid fuel sold for use, or used in a diesel... levied at the retail level, and thus excludable when separately stated, depends, of course, upon the law...

  2. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... greater than 1 kg of acute hazardous waste listed in § 261.31 or § 261.33(e) in a calendar month, who does... greater than 1 kg of acute hazardous waste listed in § 261.31or § 261.33(e) in a calendar month, must... 262.42 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  3. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... greater than 1 kg of acute hazardous waste listed in § 261.31 or § 261.33(e) in a calendar month, who does... greater than 1 kg of acute hazardous waste listed in § 261.31or § 261.33(e) in a calendar month, must... 262.42 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  4. Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase

    PubMed Central

    Stephenson, Jason R.; Stacey, Julie A.; Morgenthaler, Justin B.; Friesen, Jon A.; Lash, Timothy D.; Jones, Marjorie A.

    2007-01-01

    Coproporphyrinogen oxidase (CPO) is the sixth enzyme in the heme biosynthetic pathway, catalyzing two sequential oxidative decarboxylations of propionate moieties on coproporphyrinogen-III forming protoporphyrinogen-IX through a monovinyl intermediate, harderoporphyrinogen. Site-directed mutagenesis studies were carried out on three invariant amino acids, aspartate 400, arginine 262, and arginine 401, to determine residue contribution to substrate binding and/or catalysis by human recombinant CPO. Kinetic analyses were performed on mutant enzymes incubated with three substrates, coproporphyrinogen-III, harderoporphyrinogen, or mesoporphyrinogen-VI, in order to determine catalytic ability to perform the first and/or second oxidative decarboxylation. When Asp400 was mutated to alanine no divinyl product was detected, but the production of a small amount of monovinyl product suggested the Km value for coproporphyrinogen-III did not change significantly compared to the wild-type enzyme. Upon mutation of Arg262 to alanine, CPO was again a poor catalyst for the production of a divinyl product, with a catalytic efficiency <0.01% compared to wild-type, including a 15-fold higher Km for coproporphyrinogen-III. The efficiency of divinyl product formation for mutant enzyme Arg401Ala was ∼3% compared to wild-type CPO, with a threefold increase in the Km value for coproporphyrinogen-III. These data suggest Asp400, Arg262, and Arg401 are active site amino acids critical for substrate binding and/or catalysis. Possible roles for arginine 262 and 401 include coordination of carboxylate groups of coproporphyrinogen-III, while aspartate 400 may initiate deprotonation of substrate, resulting in an oxidative decarboxylation. PMID:17242372

  5. Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase.

    PubMed

    Stephenson, Jason R; Stacey, Julie A; Morgenthaler, Justin B; Friesen, Jon A; Lash, Timothy D; Jones, Marjorie A

    2007-03-01

    Coproporphyrinogen oxidase (CPO) is the sixth enzyme in the heme biosynthetic pathway, catalyzing two sequential oxidative decarboxylations of propionate moieties on coproporphyrinogen-III forming protoporphyrinogen-IX through a monovinyl intermediate, harderoporphyrinogen. Site-directed mutagenesis studies were carried out on three invariant amino acids, aspartate 400, arginine 262, and arginine 401, to determine residue contribution to substrate binding and/or catalysis by human recombinant CPO. Kinetic analyses were performed on mutant enzymes incubated with three substrates, coproporphyrinogen-III, harderoporphyrinogen, or mesoporphyrinogen-VI, in order to determine catalytic ability to perform the first and/or second oxidative decarboxylation. When Asp400 was mutated to alanine no divinyl product was detected, but the production of a small amount of monovinyl product suggested the K(m) value for coproporphyrinogen-III did not change significantly compared to the wild-type enzyme. Upon mutation of Arg262 to alanine, CPO was again a poor catalyst for the production of a divinyl product, with a catalytic efficiency <0.01% compared to wild-type, including a 15-fold higher K(m) for coproporphyrinogen-III. The efficiency of divinyl product formation for mutant enzyme Arg401Ala was approximately 3% compared to wild-type CPO, with a threefold increase in the K(m) value for coproporphyrinogen-III. These data suggest Asp400, Arg262, and Arg401 are active site amino acids critical for substrate binding and/or catalysis. Possible roles for arginine 262 and 401 include coordination of carboxylate groups of coproporphyrinogen-III, while aspartate 400 may initiate deprotonation of substrate, resulting in an oxidative decarboxylation.

  6. National Faculty Salary Survey by Discipline and Rank in State Colleges and Universities, 1985-86.

    ERIC Educational Resources Information Center

    Appalachian State Univ., Boone, NC.

    Salary data for full-time faculty in 46 selected disciplines at 262 state colleges and universities are presented based on the 1985-86 National Faculty Salary Survey by Discipline and Rank in State Colleges and Universities. Information was collected on salaries for 63,623 faculty members employed at 262 state colleges and universities.…

  7. 40 CFR 262.90 - Project XL for Public Utilities in New York State.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Project XL for Public Utilities in New... Utilities § 262.90 Project XL for Public Utilities in New York State. (a) The following definitions apply to..., or any company that provides electric power or telephone service and is regulated by New York State's...

  8. Campaign-level Science Traceability for Earth Observation System Architecting

    DTIC Science & Technology

    2009-05-01

    aerosol size and size distribution 2.4.4 canopy density 1.2.1 Atmospheric temperature fields 2.6.2 landcover status 1.3.1 Water vapor profiles 2.7.1...imagery (land) 3.15516 1.5.2 Cloud type 0.20923951 2.6.1 land use 0.060095 1.5.3 Cloud amount/distribution 0.26680361 2.6.2 landcover status

  9. 40 CFR 264.1050 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 270, or (2) A unit (including a hazardous waste recycling unit) that is not exempt from permitting under the provisions of 40 CFR 262.34(a) (i.e., a hazardous waste recycling unit that is not a “90-day... provisions of 40 CFR 262.34(a) (i.e., a “90-day” tank or container) and is not a recycling unit under the...

  10. 40 CFR 264.1050 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 270, or (2) A unit (including a hazardous waste recycling unit) that is not exempt from permitting under the provisions of 40 CFR 262.34(a) (i.e., a hazardous waste recycling unit that is not a “90-day... provisions of 40 CFR 262.34(a) (i.e., a “90-day” tank or container) and is not a recycling unit under the...

  11. 40 CFR 264.1050 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 270, or (2) A unit (including a hazardous waste recycling unit) that is not exempt from permitting under the provisions of 40 CFR 262.34(a) (i.e., a hazardous waste recycling unit that is not a “90-day... provisions of 40 CFR 262.34(a) (i.e., a “90-day” tank or container) and is not a recycling unit under the...

  12. 40 CFR 264.1050 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 270, or (2) A unit (including a hazardous waste recycling unit) that is not exempt from permitting under the provisions of 40 CFR 262.34(a) (i.e., a hazardous waste recycling unit that is not a “90-day... provisions of 40 CFR 262.34(a) (i.e., a “90-day” tank or container) and is not a recycling unit under the...

  13. 40 CFR 264.1050 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 270, or (2) A unit (including a hazardous waste recycling unit) that is not exempt from permitting under the provisions of 40 CFR 262.34(a) (i.e., a hazardous waste recycling unit that is not a “90-day... provisions of 40 CFR 262.34(a) (i.e., a “90-day” tank or container) and is not a recycling unit under the...

  14. Navy Explosive Ordnance Disposal School Master Development Plan for Test Area D-51 Final Environmental Assessment

    DTIC Science & Technology

    2008-01-01

    Year 2005 through 2009: VOCE = .016 * Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips...NOxE = .013 * Trips PM10E = .0022 * Trips COE = .262 * Trips To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII

  15. 40 CFR 262.204 - How an eligible academic entity indicates it will withdraw from the requirements of this subpart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false How an eligible academic entity... Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.204 How an eligible academic entity indicates it will withdraw from the requirements of this subpart. (a) An eligible academic entity...

  16. 40 CFR 262.209 - Where and when to make the hazardous waste determination and where to send containers of unwanted...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Academic Entities § 262.209 Where and when to make the hazardous waste determination and where to send... quantity generators—an eligible academic entity must ensure that a trained professional makes a hazardous... quantity generators—an eligible academic entity must ensure that a trained professional makes a hazardous...

  17. 40 CFR 262.204 - How an eligible academic entity indicates it will withdraw from the requirements of this subpart.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false How an eligible academic entity... Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.204 How an eligible academic entity indicates it will withdraw from the requirements of this subpart. (a) An eligible academic entity...

  18. 40 CFR 262.204 - How an eligible academic entity indicates it will withdraw from the requirements of this subpart.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false How an eligible academic entity... Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.204 How an eligible academic entity indicates it will withdraw from the requirements of this subpart. (a) An eligible academic entity...

  19. 40 CFR 262.209 - Where and when to make the hazardous waste determination and where to send containers of unwanted...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Academic Entities § 262.209 Where and when to make the hazardous waste determination and where to send... quantity generators—an eligible academic entity must ensure that a trained professional makes a hazardous... quantity generators—an eligible academic entity must ensure that a trained professional makes a hazardous...

  20. 40 CFR 262.204 - How an eligible academic entity indicates it will withdraw from the requirements of this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false How an eligible academic entity... Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.204 How an eligible academic entity indicates it will withdraw from the requirements of this subpart. (a) An eligible academic entity...

  1. 40 CFR 262.204 - How an eligible academic entity indicates it will withdraw from the requirements of this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false How an eligible academic entity... Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.204 How an eligible academic entity indicates it will withdraw from the requirements of this subpart. (a) An eligible academic entity...

  2. 40 CFR 262.209 - Where and when to make the hazardous waste determination and where to send containers of unwanted...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Academic Entities § 262.209 Where and when to make the hazardous waste determination and where to send... quantity generators—an eligible academic entity must ensure that a trained professional makes a hazardous... quantity generators—an eligible academic entity must ensure that a trained professional makes a hazardous...

  3. Computational prediction of Mg-isotope fractionation between aqueous [Mg(OH2)6]2+ and brucite

    NASA Astrophysics Data System (ADS)

    Colla, Christopher A.; Casey, William H.; Ohlin, C. André

    2018-04-01

    The fractionation factor in the magnesium-isotope fractionation between aqueous solutions of magnesium and brucite changes sign with increasing temperature, as uncovered by recent experiments. To understand this behavior, the Reduced Partition Function Ratios and isotopic fractionation factors (Δ26/24Mgbrucite-Mg(aq)) are calculated using molecular models of aqueous [Mg(OH2)6]2+ and the mineral brucite at increasing levels of density functional theory. The calculations were carried out on the [Mg(OH2)6]2+·12H2O cluster, along with different Pauling-bond-strength-conserving models of the mineral lattice of brucite. Three conclusions were reached: (i) all levels of theory overestimate bond distances in the aqua ion complex relative to Tutton's salts; (ii) the calculations predict that brucite at 298.15 K is always enriched in the heavy isotope, in contrast with experimental observations; (iii) the temperature dependencies of Wimpenny et al. (2014) and Li et al. (2014) could only be achieved by fixing the bond distances in the [Mg(OH2)6]2+·12H2O cluster to values close to those observed in crystals that trap the hydrated ion.

  4. Polymorphism of catalase gene (CAT C-262T) in women with endometriosis.

    PubMed

    Zarafshan, S Sabouhi; Salehi, Z; Salahi, E; Sabet, E Eskafi; Shabanipour, S; Zahiri, Z

    2015-04-01

    Endometriosis is defined as the presence of ectopic endometrial glands and stroma outside of the uterine cavity. Recent studies have shown that the oxidative stress causes irreparable damage, which leads to oxidative enzymopathies. Catalase gene encodes an antioxidant enzyme, detoxifying hydrogen peroxide to H2O and O2. The aim of this study was to determine whether the polymorphism at position -262 in the promoter region of catalase gene (C-262T), which alters the expression and enzyme blood levels, could have an impact on the risk of endometriosis. Extracted DNA from peripheral blood leucocytes was genotyped using allele-specific PCR (AS-PCR). The χ(2)-test was used for statistical analyses. In endometriosis subjects, the frequencies of the CAT CC/CT/TT were 67.5%, 32.5% and 0%, respectively, while in healthy women, they were 12%, 68% and 20%, respectively. Significant differences in allele and genotype distribution among controls and patients were found (OR, 178.76 95% CI, 10.11-3159.1202; p = 0.0004). This study indicates that catalase C-262T polymorphism is associated with the endometriosis. Randomised multicentre trials with greater sample sizes are still needed to clarify our results.

  5. Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population.

    PubMed

    Mrowicki, Jerzy; Mrowicka, Małgorzata; Majsterek, Ireneusz; Mik, Michał; Dziki, Adam; Dziki, Łukasz

    2016-12-01

    Inflammatory bowel disease (IBD) are a heterogeneous group of disorders in the course dominated by chronic, recurrent gastrointestinal inflammation. It is believed that the activation of IBD occurs in patients with a genetic predisposition to their development. Chronic inflammation develops as a result of an excessive reaction of the immune system principally under the influence of environmental risk factors. Among them, it has been shown that the mechanism of oxidative stress is associated with the pathophysiology of inflammatory bowel disease, responsible for the commencement and progress of these diseases. The aim of the study was the relationship between single nucleotide polymorphisms (SNPs) of individual antioxidant enzymes, and the prevalence of inflammatory bowel disease that may be associated with increased levels of oxidative stress. A total of 111 IBD patients, including 65 patients with ulcerative colitis (UC) and 46 with Crohn's disease (CD) and 125 healthy controls recruited from the Polish population, were genotyped for CAT -262C / T (rs1001179), SOD + 35A / C (rs2234694), GPx Pro 197 Leu polymorphisms. Genotyping of CAT, SOD, GPx gene polymorphism was performed by a RFLP-PCR. The performed analysis of genetic polymorphisms of antioxidant enzymes showed that polymorphic variant of the CAT -262 C / T may have protective effects in patients with ulcerative colitis in the range of genotype C / T; OR = 0.49 (0.25-0.99), p = 0.044. Trend protective, but statistically unrelated, it was also observed for genotype T / T and T allele of the same polymorphism and genotypes and alleles + 35A / C SOD1 in UC as well as polymorphic variants CAT -262 C / T, Pro197Leu of GPx1, + 35A / C SOD1 in CD. The results were compared with a control group of potentially healthy individuals without such diseases. It has been shown that the polymorphism of antioxidant enzymes CAT gene -262 C / T may have protective effects in patients who are carriers of a genotype C / T at the UC. The potential protective effect without statistical relationships were also observed for other genotypes and alleles studied polymorphic variants of antioxidant enzymes in CD and CAT- 262C / T and + 35 A / C SOD1 in UC. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and other trends observed for other polymorphic variants tested genes.

  6. [Association of human papillomavirus infection with other microbial pathogens in gynecology].

    PubMed

    Zheng, Mei-yun; Zhao, He-lan; Di, Jun-ping; Lin, Gan; Lin, Ying; Lin, Xi; Zheng, Min-qiao

    2010-06-01

    To Investigate correlation between screening assay of human papillomavirus (HPV) and microbial pathogens in gynecology. Cervical samples were collected to search for HPV, bacteria and yeast infections in gynecologic outpatients. HPV typing was carried out by PCR and sequencing on cervical brush specimens. Chlamydia trachomatis was identified by strand displacement amplification (SDA) and the other microorganisms were detected by conventional methods. All data were analyzed to investigate the correlation among them. In this cross-sectional study, among 857 enrolled outpatients, there were 266 cases with positive HPV DNA, and the rate of infection was 31.0% (266/857). HPV genotype showed that thirty-five different HPV types were identified, of which HPV16 was the most prevalent (14.5%, 38/262), followed by HPV58 (9.2%, 24/262), HPV53 (8.0%, 21/262) and HPV42 (6.1%, 16/262); while other genotypes were present in less than 5% of HPV positive women. According to the reclassification, the aggregated percentage (high-risk and probably high-risk) of detected HPV was 58.8% (154/262), 27.9% (73/262) for low-risk and 13.4% (35/262) for unknown-risk HPV types. Among HPV positive women, cervical brush specimens results showed that more than 60% cases with normal cytology, 3.8% (10/266) with high-grade squamous intraepithelial lesions (HSIL), 29.7% (79/266) with low-grade squamous intraepithelial lesions (LSIL) and 3.0% (8/266) with atypical squamous cells of undetermined significance (ASCUS), respectively. Statistical analyses revealed there was a significant association between the infected HPV and Chlamydia trachomatis or Ureaplasma urealyticum (> 10,000 CCU/ml; all P < 0.01), while no correlation was found between HPV infection and bacterial vaginosis, streptococcus agalactiae, candida, Trichomonas vaginalis or Ureaplasma urealyticum (≤ 10 000 CCU/ml; all P > 0.05). Among the cases with bacterial vaginosis, the positive rate of HPV infected was 42.6%. Chlamydia trachomatis was one of the high-risk factors for the infection of HPV (OR = 2.82, 95% CI: 1.74 - 4.57). Mycoplasma hominis was isolated only in 2 cases, no patient was infected with Neisseria gonorrhoeae. Although bacterial vaginosis was not significantly associated with HPV, it was more common among the HPV positive women. There is the significant association between HPV and Chlamydia trachomatis or Ureaplasma urealyticum which may be increase the infection of HPV. These data suggest that it may be important to screen for the simultaneous presence of different microorganisms which may have synergistic pathological effects.

  7. Total and Differential Leukocyte Counts in Relation to Incidence of Diabetes Mellitus: A Prospective Population-Based Cohort Study.

    PubMed

    Borné, Yan; Smith, J Gustav; Nilsson, Peter M; Melander, Olle; Hedblad, Bo; Engström, Gunnar

    2016-01-01

    High concentrations of leukocytes in blood have been associated with diabetes mellitus. This prospective study aimed to explore whether total and differential leukocyte counts are associated with incidence of diabetes. A missense variant R262W in the SH2B3 (SH2B adaptor protein 3) gene, coding for a protein that negatively regulates hematopoietic cell proliferation, was also studied in relation to incidence of diabetes. Leukocyte count and its subtypes (neutrophils, lymphocytes and mixed cells) were analyzed in 26,667 men and women, 45-73 years old, from the population-based Malmö Diet and Cancer study. Information about the R262W polymorphism (rs3184504) in SH2B3 was genotyped in 24,489 subjects. Incidence of diabetes was studied during a mean follow-up of 14 years. Cox proportional hazards regression was used to examine incidence of diabetes by total and differential leukocyte counts. Mendelian randomization analysis using R262W as an instrumental variable was performed with two-stage least squares regression. A total of 2,946 subjects developed diabetes during the follow-up period. After taking several possible confounders into account, concentrations of total leukocyte count, neutrophils and lymphocytes were all significantly associated with incidence of diabetes. The adjusted hazard ratios (95% confidence interval; quartile 4 vs quartile 1) were 1.37 (1.22-1.53) for total leukocytes, 1.33 (1.19-1.49) for neutrophils and 1.29 (1.15-1.44) for lymphocytes. The R262W polymorphism was strongly associated with leukocytes (0.11x109 cells/l per T allele, p = 1.14 x10-12), lymphocytes (p = 4.3 x10-16), neutrophils (p = 8.0 x10-6) and mixed cells (p = 3.0 x10-6). However, there was no significant association between R262W and fasting glucose, HbA1c or incidence of diabetes. Concentrations of total leukocytes, neutrophils and lymphocytes are associated with incidence of diabetes. However, the lack of association with the R262W polymorphism suggests that the associations may not be causal, although limitations in statistical power and balancing pleiotropic effects cannot be excluded.

  8. MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women.

    PubMed

    Kakkoura, Maria G; Demetriou, Christiana A; Loizidou, Maria A; Loucaides, Giorgos; Neophytou, Ioanna; Malas, Simon; Kyriacou, Kyriacos; Hadjisavvas, Andreas

    2016-06-01

    Oxidative stress arises due to a cellular imbalance in oxidants and antioxidants and/or due to an altered activity of antioxidant enzymes, caused by SNPs. Oxidative stress increases susceptibility to breast cancer (BC) risk, and we previously showed that the Mediterranean diet (MD), which is rich in antioxidants, reduces BC risk in Greek-Cypriot women. Here, we investigated the effect of MnSOD (p.Val16Ala, rs4880) and CAT (-262C>T, rs1001179) SNPs on the association between the MD and BC risk in the case-control study of BC MASTOS in Cyprus. Dietary intake data were obtained using a 32-item food frequency questionnaire, from which a dietary pattern was previously derived, using principal component analysis. This pattern included high loadings of vegetables, fruit, legumes and fish, a combination that closely resembles the MD and was used as our dietary variable. High vegetable intake lowered BC risk in women with at least one MnSOD Val allele (ORHigh vs. Low for Val/Val = 0.56, 95 % CI 0.35-0.88, for Val/Ala = 0.57, 95 % CI 0.39-0.82), or one CAT -262C allele (ORHigh vs. Low for -262CC = 0.66, 95 % CI 0.47-0.92, for -262CT = 0.53, 95 % CI 0.35-0.81). High fish intake conferred a decreased BC risk of CAT -262CC women (ORQ4 vs. Q1 0.66, 95 % CI 0.47-0.92) compared with the CAT -262TT women and low fish intake (ORQ2 vs. Q1 2.79, 95 % CI 1.08-7.17). Additionally, high fish intake reduced BC risk in MnSOD Val/Val women (ORQ4 vs. Q1 0.63, 95 % CI 0.40-0.98). p interaction values were, however, not statistically significant. Our results demonstrate that the antioxidative effects of the MD against BC risk may be enhanced by the wild-type alleles of the MnSOD or CAT SNPs among Greek-Cypriot women.

  9. Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

    PubMed Central

    Iijima-Ando, Kanae; Sekiya, Michiko; Suzuki, Emiko; Lu, Bingwei; Iijima, Koichi M.

    2012-01-01

    Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in the number of mitochondria in the axon has been implicated in AD. In this study, we investigated whether and how loss of axonal mitochondria promotes tau phosphorylation and toxicity in vivo. Using transgenic Drosophila expressing human tau, we found that RNAi–mediated knockdown of milton or Miro, an adaptor protein essential for axonal transport of mitochondria, enhanced human tau-induced neurodegeneration. Tau phosphorylation at an AD–related site Ser262 increased with knockdown of milton or Miro; and partitioning defective-1 (PAR-1), the Drosophila homolog of mammalian microtubule affinity-regulating kinase, mediated this increase of tau phosphorylation. Tau phosphorylation at Ser262 has been reported to promote tau detachment from microtubules, and we found that the levels of microtubule-unbound free tau increased by milton knockdown. Blocking tau phosphorylation at Ser262 site by PAR-1 knockdown or by mutating the Ser262 site to unphosphorylatable alanine suppressed the enhancement of tau-induced neurodegeneration caused by milton knockdown. Furthermore, knockdown of milton or Miro increased the levels of active PAR-1. These results suggest that an increase in tau phosphorylation at Ser262 through PAR-1 contributes to tau-mediated neurodegeneration under a pathological condition in which axonal mitochondria is depleted. Intriguingly, we found that knockdown of milton or Miro alone caused late-onset neurodegeneration in the fly brain, and this neurodegeneration could be suppressed by knockdown of Drosophila tau or PAR-1. Our results suggest that loss of axonal mitochondria may play an important role in tau phosphorylation and toxicity in the pathogenesis of AD. PMID:22952452

  10. Association of catalase gene polymorphisms with catalase activity and susceptibility to systemic lupus erythematosus in the Suez Canal area, Egypt.

    PubMed

    Ghaly, M S; Ghattas, M H; Labib, S M

    2012-10-01

    The present study evaluated the relationship of genetic variants in both promoter (-262 C/T) and in exonic (389 C/T) regions of the catalase (CAT) gene to CAT activity and risk of systemic lupus erythematosus (SLE) in Suez Canal-area patients. CAT gene polymorphisms were assessed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). CAT activity was measured by using a spectrophotometer. We compared the frequencies of CAT 389 C/T and -262 C/T polymorphic variants between SLE patients (n = 103) and healthy controls (n = 103). CAT 389 C/T is associated with SLE susceptibility, with the T allele being significantly more frequent among SLE patients than healthy controls. There was no association, however, between CAT activity and genotypes of 389 C/T. We did not observe significant differences in the prevalence of CAT -262 C/T polymorphic variants in SLE patients and controls, however, we found that patients with the CAT -262 CT and TT genotypes had low CAT activity, and these genotypes showed a significant association with thrombocytopaenia, leukopaenia and the presence of anti-snRNP in SLE patients. In conclusion, the present study supports the notion of in vivo oxidative stress in SLE as indicated by the decrease in CAT activity. The allelic variations in the CAT gene -262 are more likely to affect the expression or the function of the enzyme. Since CAT may be pathogenetically linked to SLE, and owing to its free-radical origin, it appears reasonable to target lipid peroxidation by dietary and/or pharmacological antioxidants.

  11. Final Environmental Assessment: For Construction of an Addition to the Joint Strike Fighter Reprogramming Facility, Building 614, on Eglin Air Force Base, Florida

    DTIC Science & Technology

    2007-01-01

    VOCE = .016 * Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013...Trips PM10E = .0022 * Trips COE = .262 * Trips E = emissions To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 lbs

  12. Cultivar and Metal-Specific Effects of Endophytic Bacteria in Helianthus tuberosus Exposed to Cd and Zn

    PubMed Central

    Thijs, Sofie; Lobo, Mª Carmen; Weyens, Nele; Pérez-Sanz, Araceli

    2017-01-01

    Plant growth promoting endophytic bacteria (PGPB) isolated from Brassica napus were inoculated in two cultivars of Helianthus tuberosus (VR and D19) growing on sand supplemented with 0.1 mM Cd or 1 mM Zn. Plant growth, concentrations of metals and thiobarbituric acid (TBA) reactive compounds were determined. Colonization of roots of H. tuberosus D19 by Pseudomonas sp. 262 was evaluated using confocal laser scanning microscopy. Pseudomonas sp. 228, Serratia sp. 246 and Pseudomonas sp. 262 significantly enhanced growth of H. tuberosus D19 exposed to Cd or Zn. Pseudomonas sp. 228 significantly increased Cd concentrations in roots. Serratia sp. 246, and Pseudomonas sp. 256 and 228 resulted in significantly decreased contents of TBA reactive compounds in roots of Zn exposed D19 plants. Growth improvement and decrease of metal-induced stress were more pronounced in D19 than in VR. Pseudomonas sp. 262-green fluorescent protein (GFP) colonized the root epidermis/exodermis and also inside root hairs, indicating that an endophytic interaction was established. H. tuberosus D19 inoculated with Pseudomonas sp. 228, Serratia sp. 246 and Pseudomonas sp. 262 holds promise for sustainable biomass production in combination with phytoremediation on Cd and Zn contaminated soils. PMID:28934107

  13. Cultivar and Metal-Specific Effects of Endophytic Bacteria in Helianthus tuberosus Exposed to Cd and Zn.

    PubMed

    Montalbán, Blanca; Thijs, Sofie; Lobo, Mª Carmen; Weyens, Nele; Ameloot, Marcel; Vangronsveld, Jaco; Pérez-Sanz, Araceli

    2017-09-21

    Plant growth promoting endophytic bacteria (PGPB) isolated from Brassica napus were inoculated in two cultivars of Helianthus tuberosus (VR and D19) growing on sand supplemented with 0.1 mM Cd or 1 mM Zn. Plant growth, concentrations of metals and thiobarbituric acid (TBA) reactive compounds were determined. Colonization of roots of H. tuberosus D19 by Pseudomonas sp. 262 was evaluated using confocal laser scanning microscopy. Pseudomonas sp. 228, Serratia sp. 246 and Pseudomonas sp. 262 significantly enhanced growth of H. tuberosus D19 exposed to Cd or Zn. Pseudomonas sp. 228 significantly increased Cd concentrations in roots. Serratia sp. 246, and Pseudomonas sp. 256 and 228 resulted in significantly decreased contents of TBA reactive compounds in roots of Zn exposed D19 plants. Growth improvement and decrease of metal-induced stress were more pronounced in D19 than in VR. Pseudomonas sp. 262 - green fluorescent protein (GFP) colonized the root epidermis/exodermis and also inside root hairs, indicating that an endophytic interaction was established. H. tuberosus D19 inoculated with Pseudomonas sp. 228, Serratia sp. 246 and Pseudomonas sp. 262 holds promise for sustainable biomass production in combination with phytoremediation on Cd and Zn contaminated soils.

  14. Evaluation of fresh pasta-making properties of extra-strong common wheat (Triticum aestivum L.).

    PubMed

    Ito, Miwako; Maruyama-Funatsuki, Wakako; Ikeda, Tatsuya M; Nishio, Zenta; Nagasawa, Koichi; Tabiki, Tadashi; Yamauchi, Hiroaki

    2012-12-01

    The relationship between characterictics of flour of common wheat varieties and fresh pasta-making qualitites was examined, and the fresh pasta-making properties of extra-strong varieties that have extra-strong dough were evaluated. There was a positive correlation between mixing time (PT) and hardness of boiled pasta, indicating that the hardness of boiled pasta was affected by dough properties. Boiled pasta made from extra-strong varieties, Yumechikara, Hokkai 262 and Hokkai 259, was harder than that from other varieties and commercial flour. There was a negative correlation between flour protein content and brightness of boiled pasta. The colors of boiled pasta made from Yumechikara and Hokkai 262 grown under the condition of standard manuring culture were superior to those of boiled pasta made from other varieties. Discoloration of boiled pasta made from Yumechikara grown under the condition of heavy manuring culture was caused by increase of flour protein content. On the other hand, discoloration of boiled pasta made from Hokkai 262 grown under the condition of heavy manuring culture was less than that of boiled pasta made from Yumechikara. These results indicate that pasta made from extra-strong wheat varieties has good hardness and that Hokkai 262 has extraordinary fresh pasta-making properties.

  15. Evaluation of fresh pasta-making properties of extra-strong common wheat (Triticum aestivum L.)

    PubMed Central

    Ito, Miwako; Maruyama-Funatsuki, Wakako; Ikeda, Tatsuya M.; Nishio, Zenta; Nagasawa, Koichi; Tabiki, Tadashi; Yamauchi, Hiroaki

    2012-01-01

    The relationship between characterictics of flour of common wheat varieties and fresh pasta-making qualitites was examined, and the fresh pasta-making properties of extra-strong varieties that have extra-strong dough were evaluated. There was a positive correlation between mixing time (PT) and hardness of boiled pasta, indicating that the hardness of boiled pasta was affected by dough properties. Boiled pasta made from extra-strong varieties, Yumechikara, Hokkai 262 and Hokkai 259, was harder than that from other varieties and commercial flour. There was a negative correlation between flour protein content and brightness of boiled pasta. The colors of boiled pasta made from Yumechikara and Hokkai 262 grown under the condition of standard manuring culture were superior to those of boiled pasta made from other varieties. Discoloration of boiled pasta made from Yumechikara grown under the condition of heavy manuring culture was caused by increase of flour protein content. On the other hand, discoloration of boiled pasta made from Hokkai 262 grown under the condition of heavy manuring culture was less than that of boiled pasta made from Yumechikara. These results indicate that pasta made from extra-strong wheat varieties has good hardness and that Hokkai 262 has extraordinary fresh pasta-making properties. PMID:23341748

  16. Army Communicator. Volume 27, Number 1, Spring 2002

    DTIC Science & Technology

    2002-01-01

    defense; Jim Garamone; 26:4 Signal officers sought for Ranger Regiment; 26:2 Signal support for XVIII Airborne Corps’ first warfighter exercise; MAJ...risks, official says; Jim Garamone; 26:2 Recruit attrition rates fall across the services; Gerry Gilmore; 26:3 Signal officers sought for Ranger ...cavernous C-5 Galaxy at Howard Air Force Base. After we lowered his casket in place on the aircraft, we knelt beside his casket and bid Ward a final

  17. Lake Holloman Recreational Area Development Environmental Assessment

    DTIC Science & Technology

    2009-08-01

    facilities Total daily trips are applied to the following factors depending on the corresponding years. Year 2005 through 2009: VOCE = .016...Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E = .0022...Trips COE = .262 * Trips To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 NOx (tons/yr) = NOxE * DPYII/2000

  18. Shaw Air Force Base Infrastructure Project Environmental Assessment

    DTIC Science & Technology

    2008-09-01

    are the applied to the following factors depending on the corresponding years. Year 2009: VOCE = .016 * Trips NOXE = .015 * Trips PM10E...0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOXE = .013 * Trips PM10E = .0022 * Trips COE = .262 * Trips To...convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 Nox (tons/yr) = NOxE * DPYII/2000 PM10(tons/yr) = PM10E

  19. C (G)-Band & X (I) - Band Noncoherent Radar Transponder Performance Specification Standard

    DTIC Science & Technology

    2002-04-01

    TRAINING RANGE NEVADA TEST SITE STANDARD 262-02 ELECTRONIC TRAJECTORY MEASUREMENTS GROUP C (G) – BAND & X (I) – BAND NONCOHERENT RADAR...Date 00 Apr 2002 Report Type N/A Dates Covered (from... to) - Title and Subtitle C (G)-Band & X (I) - Band Noncoherent Radar Transponder...Number of Pages 157 i STANDARD 262-02 C (G) – BAND & X (I) – BAND NONCOHERENT RADAR TRANSPONDER PERFORMANCE SPECIFICATION STANDARD APRIL 2002 Prepared by

  20. Factors Influencing Residency Program Selection by Medical Students Pursuing Obstetrics and Gynecology.

    PubMed

    Alston, Meredith J; Metz, Torri D; Fothergill, Russell; Meg Autry, Amy; Wagner, Sarah A; Allshouse, Amanda A; Stephenson-Famy, Alyssa

    2017-02-01

    Little is known about the factors that influence medical student selection of obstetrics and gynecology (ob-gyn) residency programs. We assessed the factors influencing residency program selection by fourth-year medical students pursuing ob-gyn training. A voluntary, anonymous, 19-question survey of residency selection factors was distributed to all fourth-year medical students interviewing at 1 of 5 academic ob-gyn departments for a residency position during the 2013-2014 interview season. Participants were surveyed about the relative importance (not important, somewhat important, important) of various residency selection factors, including operative experience, exposure to subspecialties, curricular experience, access to fellowships, and administrative aspects of residency, including adherence to duty hour restrictions. Of 322 potential respondents, 262 (81%) completed the survey. Surgical training and training in laparoscopic surgery were deemed "important" by nearly all respondents (98%, 258 of 262, and 97%, 253 of 262, respectively). Factors that were considered "not important" by a significant group of respondents included maternity/paternity leave policies (22%, 58 of 259); opportunity for international rotations/electives (20%, 51 of 259); exposure to quality and safety initiatives (13%, 34 of 259); and training in abortion (13%, 34 of 262). Fourth-year medical students identified surgical training as the most important factor in selecting an ob-gyn residency, a finding that is particularly relevant as decreasing and changing surgical volumes affect residency training in this specialty.

  1. Petrogenesis of lunar highlands meteorites: Dhofar 025, Dhofar 081 Dar al Gani 262, and Dar al Gani 400

    NASA Astrophysics Data System (ADS)

    Cahill, J. T.; Floss, C.; Anand, M.; Taylor, L. A.; Nazarov, M. A.; Cohen, B. A.

    2004-04-01

    The petrogenesis of four lunar highlands meteorites, Dhofar 025 (Dho 025), Dhofar 081 (Dho 081), Dar al Gani 262 (DaG 262), and Dar al Gani 400 (DaG 400) were studied. For Dho 025, measured oxygen isotopic values and Fe-Mn ratios for mafic minerals provide corroboratory evidence that it originated on the Moon. Similarly, Fe-Mn ratios in the mafic minerals of Dho 081 indicate lunar origin. Lithologies in Dho 025 and Dho 081 include lithic clasts, granulites, and mineral fragments. A large number of lithic clasts have plagioclase AN# and coexisting mafic mineral Mg# that plot within the "gap" separating ferroan anorthosite suite (FAN) and high-magnesium suite (HMS) rocks. This is consistent with whole rock Ti-Sm ratios for Dho 025, Dho 081, and DaG 262, which are also intermediate compared to FAN and HMS lithologies. Although ion microprobe analyses performed on Dho 025, Dho 081, DaG 262, and DaG 400 clasts and minerals show far stronger FAN affinities than whole rock data suggest, most clasts indicate admixture of £12% HMS component based on geochemical modeling. In addition, coexisting plagioclase-pyroxene REE concentration ratios in several clasts were compared to experimentally determined plagioclase-pyroxene REE distribution coefficient ratios. Two Dho 025 clasts have concordant plagioclase-pyroxene profiles, indicating that equilibrium between these minerals has been sustained despite shock metamorphism. One clast has an intermediate FAN-HMS composition. These lunar meteorites appear to represent a type of highland terrain that differs substantially from the KREEP-signatured impact breccias that dominate the lunar database. From remote sensing data, it is inferred that the lunar far side appears to have appropriate geochemical signatures and lithologies to be the source regions for these rocks; although, the near side cannot be completely excluded as a possibility. If these rocks are, indeed, from the far side, their geochemical characteristics may have far-reaching implications for our current scientific understanding of the Moon.

  2. Final Environmental Assessment for the Military Family Housing Privatization Initiative Columbus Air Force Base, Mississippi

    DTIC Science & Technology

    2005-05-03

    daily trips are applied to the following factors depending on the corresponding years. Year 2005 through 2009: VOCE = .016 * Trips NOxE = .015...Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E = .0022 * Trips COE...262 * Trips To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 NOx (tons/yr) = NOxE * DPYII/2000 PM10 (tons/yr

  3. Environmental Assessment for the Construction of a Three-Bay Multi-Aircraft Hangar Tinker Air Force Base, Oklahoma

    DTIC Science & Technology

    2008-01-01

    Years 2005 through 2009: VOCE = .016 * Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Appendix A: Air Quality January 2008...Final EA for the Construction of a Three-Bay Multi-Aircraft Hangar Page A-9 Tinker Air Force Base, Oklahoma Years 2010 and beyond: VOCE = .012...Trips NOxE = .013 * Trips PM10E = .0022 * Trips COE = .262 * Trips To convert from pounds per day to tons per year: VOC (tons/year) = VOCE

  4. Final Environmental Assessment for the Okaloosa Regional Airport Expansion at Eglin Air Force Base, FL

    DTIC Science & Technology

    2006-06-01

    construction Total daily trips are then applied to the following factors depending on the corresponding years. Year 2005 through 2009: VOCE ...016 * Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E...0022 * Trips COE = .262 * Trips To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 Nox (tons/yr) = NOxE

  5. Superheavy element chemistry at GARIS

    NASA Astrophysics Data System (ADS)

    Haba, Hiromitsu

    2016-12-01

    A gas-jet transport system has been installed to the RIKEN GAs-filled Recoil Ion Separator, GARIS to start up SuperHeavy Element (SHE) chemistry. This system is a promising approach for exploring new frontiers in SHE chemistry: background radioactivities from unwanted by-products are suppressed, a high gas-jet transport yield is achieved, and new chemical reactions can be investigated. Useful radioisotopes of 261Rfa,b, 262Db, and 265Sga,b for chemical studies were produced in the reactions of 248Cm(18O,5n)261Rfa,b, 248Cm(19F,5n)262Db, and 248Cm(22Ne,5n)265Sga,b, respectively. They were successfully extracted to a chemistry laboratory by the gas-jet method. Production and decay properties of 261Rfa,b, 262Db, and 265Sga,b were investigated in detail with the rotating wheel apparatus for α- and spontaneous fission spectrometry. Present status and perspectives of the SHE chemistry at GARIS are also briefly presented.

  6. A novel fibrinogen variant--Liberec: dysfibrinogenaemia associated with gamma Tyr262Cys substitution.

    PubMed

    Kotlín, Roman; Sobotková, Alzbeta; Suttnar, Jirí; Salaj, Peter; Walterová, Lenka; Riedel, Tomás; Reicheltová, Zuzana; Dyr, Jan Evangelista

    2008-08-01

    A 22-yr-old woman had abnormal preoperative coagulation test results and congenital dysfibrinogenaemia was suspected. The patient from Liberec (Czech Republic) had a low fibrinogen plasma level as determined by Clauss method, normal fibrinogen level as determined by immunoturbidimetrical method, and prolonged thrombin time. To identify the genetic mutation responsible for this dysfibrinogen, genomic DNA extracted from the blood was analysed. Fibrin polymerisation measurement, kinetics of fibrinopeptide release, fibrinogen clottability measurement and scanning electron microscopy were performed. DNA sequencing showed the heterozygous fibrinogen gamma Y262C mutation. Kinetics of fibrinopeptide release was normal, however fibrin polymerisation was impaired. Fibrinogen clottability measurement showed that only about 45% molecules of fibrinogen are involved in the clot formation. Scanning electron microscopy revealed thicker fibres, which were significantly different from the normal control. A case of dysfibrinogenaemia, found by routine coagulation testing, was genetically identified as a novel fibrinogen variant (gamma Y262C) that has been named Liberec.

  7. Cytogenetic landscape and impact in blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy.

    PubMed

    Chen, Z; Shao, C; Wang, W; Zuo, Z; Mou, X; Hu, S J; DiGiuseppe, J A; Zu, Y; Medeiros, L J; Hu, S

    2017-03-01

    The landscape of additional chromosomal alterations (ACAs) and their impact in chronic myeloid leukemia, blast phase (CML-BP) treated with tyrosine kinase inhibitors (TKIs) have not been well studied. Here, we investigated a cohort of 354 CML-BP patients treated with TKIs. We identified +8, an extra Philadelphia chromosome (Ph), 3q26.2 rearrangement, -7 and isochromosome 17q (i(17q)) as the major-route changes with a frequency of over 10%. In addition, +21 and +19 had a frequency of over 5%. These ACAs demonstrated lineage specificity: +8, 3q26.2 rearrangement, i(17q) and +19 were significantly more common in myeloid BP, and -7 more common in lymphoid BP; +Ph and +21 were equally distributed between two groups. Pearson correlation analysis revealed clustering of common ACAs into two groups: 3q26.2 rearrangement, -7 and i(17q) formed one group, and other ACAs formed another group. The grouping correlated with risk stratification of ACAs in CML, chronic phase. Despite the overall negative prognostic impact of ACAs, stratification of ACAs into major vs minor-route changes provided no prognostic relevance in CML-BP. The emergence of 3q26.2 rearrangement as a major-route change in the TKI era correlated with a high frequency of ABL1 mutations, supporting a role for TKI resistance in the changing cytogenetic landscape in CML-BP.

  8. The 1984 ARI Survey of Army Recruits. Codebook for Summer 84 Active Army Survey Respondents

    DTIC Science & Technology

    1986-05-01

    ARMY SURVEY RESPONDENTS T261 - DO YOU HATCH ANY OF THE FOLLOWING PROGRAMS OR PROGRAMMING TYPES ON TV? - NBA BASKETBALL . RAN DATA ICARD i1 COLS ILENGTHII... BASKETBALL 280 T262 WATCH TV PROG:COLLEGE BASKETBALL 281 T263 WATCH TV PROG:NHL HOCKEY 282 T264 WATCH TV PROG:PROFESSIONAL WRESTLING 283 T265 WATCH TV...SURVEY RESPONDENTS T262 - DO YOU HATCH ANY OF THE FOLLOWING PROGRAMS OR PROGRAMMING TYPES ON TV? - COLLEGE BASKETBALL . RAW DATA ICARD #1 COLS ILENGTHII

  9. The 1985 ARI Survey of Army Recruits: Tabular Description of NPS (active) Army Accessions. Volume 1

    DTIC Science & Technology

    1987-04-01

    T261 -- WATCH TV PROG:NBA BASKETBALL DO YOU WATCH ANY OF THE FOLLOWING PROGRAMS OR PROGRAMMING TYPES ON REGULAR TV STATIONS? .- NBA BASKETBALL . 1...327𔃻 261 WATCH TV PROG:NBA BASKETBALL 328-329 T262 WATCH TV PROG:COLLEGE BASKETBALL 330-331 T263 WATCH TV PROG:NHL HOCKEY 332-333 T264 WlATCH TV...T262 -- WATCH TV PROG:COLLEGE BASKETBALL DO YOU WATCH ANY OF THE FOLLOWING PROGRAMS OR PROGRAMMING TYPES ON REGULAR TV STATIONS? - COLLEGE BASKETBALL . 1

  10. Final Environmental Assessment for Construction of a Precision Measurement Equipment Laboratory Facility on Eglin Air Force Base, FL

    DTIC Science & Technology

    2006-10-01

    daily trips are then applied to the following factors depending on the corresponding years. Year 2005 through 2009: VOCE = .016 * Trips NOxE...015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E = .0022 * Trips COE...262 * Trips E = emissions To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 lbs/ton NOx (tons/yr) = NOxE * DPYII

  11. Revised Final Environmental Review for the Construction of a New Base Exchange at Kadena Air Base, Okinawa, Japan

    DTIC Science & Technology

    2007-05-01

    factors depending on the corresponding years. Year 2005 through 2009: VOCE = .016 * Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262...Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E = .0022 * Trips COE = .262 * Trips To convert from pounds per day to...tons per year: VOC (tons/yr) = VOCE * DPYII/2000 Nox (tons/yr) = NOxE * DPYII/2000 PM10(tons/yr) = PM10E * DPYII/2000 CO (tons/yr) = COE * DPYII

  12. Navy Explosive Ordnance Disposal School Master Development Plan for Test Area D-51, Eglin Air Force Base, Florida

    DTIC Science & Technology

    2008-01-25

    depending on the corresponding years. Year 2005 through 2009: VOCE = .016 * Trips NOxE = .015 * Trips PM10E = .0022 * Trips COE = .262 * Trips Year...2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E = .0022 * Trips COE = .262 * Trips To convert from pounds per day to tons per year...VOC (tons/yr) = VOCE * DPYII/2000 NOx (tons/yr) = NOxE * DPYII/2000 PM10 (tons/yr) = PM10E * DPYII/2000 CO (tons/yr) = COE * DPYII/2000

  13. A Cyclic Nucleotide-Gated Channel Mutation Associated with Canine Daylight Blindness Provides Insight into a Role for the S2 Segment Tri-Asp motif in Channel Biogenesis

    PubMed Central

    Tanaka, Naoto; Delemotte, Lucie; Klein, Michael L.; Komáromy, András M.; Tanaka, Jacqueline C.

    2014-01-01

    Cone cyclic nucleotide-gated channels are tetramers formed by CNGA3 and CNGB3 subunits; CNGA3 subunits function as homotetrameric channels but CNGB3 exhibits channel function only when co-expressed with CNGA3. An aspartatic acid (Asp) to asparagine (Asn) missense mutation at position 262 in the canine CNGB3 (D262N) subunit results in loss of cone function (daylight blindness), suggesting an important role for this aspartic acid residue in channel biogenesis and/or function. Asp 262 is located in a conserved region of the second transmembrane segment containing three Asp residues designated the Tri-Asp motif. This motif is conserved in all CNG channels. Here we examine mutations in canine CNGA3 homomeric channels using a combination of experimental and computational approaches. Mutations of these conserved Asp residues result in the absence of nucleotide-activated currents in heterologous expression. A fluorescent tag on CNGA3 shows mislocalization of mutant channels. Co-expressing CNGB3 Tri-Asp mutants with wild type CNGA3 results in some functional channels, however, their electrophysiological characterization matches the properties of homomeric CNGA3 channels. This failure to record heteromeric currents suggests that Asp/Asn mutations affect heteromeric subunit assembly. A homology model of S1–S6 of the CNGA3 channel was generated and relaxed in a membrane using molecular dynamics simulations. The model predicts that the Tri-Asp motif is involved in non-specific salt bridge pairings with positive residues of S3/S4. We propose that the D262N mutation in dogs with CNGB3-day blindness results in the loss of these inter-helical interactions altering the electrostatic equilibrium within in the S1–S4 bundle. Because residues analogous to Tri-Asp in the voltage-gated Shaker potassium channel family were implicated in monomer folding, we hypothesize that destabilizing these electrostatic interactions impairs the monomer folding state in D262N mutant CNG channels during biogenesis. PMID:24586388

  14. Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

    PubMed Central

    Hansen, Henning G.; Søltoft, Cecilie L.; Schmidt, Jonas D.; Birk, Julia; Appenzeller-Herzog, Christian; Ellgaard, Lars

    2014-01-01

    In the ER (endoplasmic reticulum) of human cells, disulfide bonds are predominantly generated by the two isoforms of Ero1 (ER oxidoreductin-1): Ero1α and Ero1β. The activity of Ero1α is tightly regulated through the formation of intramolecular disulfide bonds to help ensure balanced ER redox conditions. Ero1β is less tightly regulated, but the molecular details underlying control of activity are not as well characterized as for Ero1α. Ero1β contains an additional cysteine residue (Cys262), which has been suggested to engage in an isoform-specific regulatory disulfide bond with Cys100. However, we show that the two regulatory disulfide bonds in Ero1α are likely conserved in Ero1β (Cys90–Cys130 and Cys95–Cys100). Molecular modelling of the Ero1β structure predicted that the side chain of Cys262 is completely buried. Indeed, we found this cysteine to be reduced and partially protected from alkylation in the ER of living cells. Furthermore, mutation of Cys100–but not of Cys262–rendered Ero1β hyperactive in cells, as did mutation of Cys130. Ero1β hyperactivity induced the UPR (unfolded protein response) and resulted in oxidative perturbation of the ER redox state. We propose that features other than a distinct pattern of regulatory disulfide bonds determine the loose redox regulation of Ero1β relative to Ero1α. PMID:27919037

  15. Shrinking of the Be disk whilst the X-ray activity increases in the binary system A0535+262

    NASA Astrophysics Data System (ADS)

    Camero-Arranz, A.; Caballero-Garcia, M. D.; Fabregat, J.; Jelinek, M.; Castro-Tirado, A.; Peris, V.

    2015-02-01

    We report on the evolution of the H & alpha; equivalent width (EW) of the Be/X-ray binary system A 0535+262/HD 245770, using observations performed with the spectrograph COLORES at the 0.6 m telescope BOOTES-2 (M & aacute;laga, Spain) on 2015-01-27 at 22:05:31.736 UTC (MJD 57049.920), and with the spectrograph located at the 51 cm telescope of the Observatorio de Aras de los Olmos of the University of Valencia on 2015-01-29 at 01:00:00 UTC (MJD 57051.042).

  16. Sorafenib Tosylate and Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia

    ClinicalTrials.gov

    2018-06-01

    Acute Myeloid Leukemia; Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)(p13.3;q13.3); RBM15-MKL1; Acute Myeloid Leukemia With a Variant RARA Translocation; Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2); GATA2, MECOM; Acute Myeloid Leukemia With t(6;9) (p23;q34.1); DEK-NUP214; Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A; Acute Myeloid Leukemia With Variant MLL Translocations; Untreated Adult Acute Myeloid Leukemia

  17. Production of Dense Compact Billet From Ti-Alloy Powder Using Equal Channel Angular Extrusion

    DTIC Science & Technology

    2007-04-06

    dry lubricant 2 175 RT 95.3 dry lubricant 3 262 RT 95.6 dry lubricant 4 21 100 95.4 dry lubricant 5 43 100 96 dry lubricant 6 175 100 96.2 dry...175 98.1 371 3 262 98.2 426 4 350 98.3 412 ECAE compaction with Al tubes 5 350 97.4 415 6 393 97.8 419 7 436 97.6 438 8* 480 98.6 431 ECAE...PRODUCTION OF DENSE COMPACT BILLET FROM Ti-ALLOY POWDER USING EQUAL CHANNEL ANGULAR EXTRUSION Final Report 4 /06/2007

  18. Addendum to the Closure Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lynn Kidman

    2008-10-01

    This document constitutes an addendum to the July 2003, Closure Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications.

  19. Ring chromosome 10: report on two patients and review of the literature.

    PubMed

    Guilherme, Roberta Santos; Kim, Chong Ae; Alonso, Luis Garcia; Honjo, Rachel S; Meloni, Vera Ayres; Christofolini, Denise Maria; Kulikowski, Leslie Domenici; Melaragno, Maria Isabel

    2013-02-01

    Ring chromosome 10--r(10)--is a rare disorder, with 14 cases reported in the literature, but only two with breakpoint determination by high-resolution techniques. We report here on two patients presenting a ring chromosome 10, studied by G-banding, fluorescent in situ hybridization (FISH), multiplex ligation-dependent probe amplification (MLPA) and SNP-array techniques, in order to investigate ring instability and determine breakpoints. Patient 1 showed a r(10)(p15.3q26.2) with a 7.9 Mb deletion in 10q26.2-q26.2, while patient 2 showed a r(10)(p15.3q26.13) with a 1.0 Mb deletion in 10p15.3 and a 8.8 Mb deletion in 10q26.13-q26.3, both unstable. While patient 1 presented with clinical features usually found in patients with r(10) and terminal 10q deletion, patient 2 presented characteristics so far not described in other patients with r(10), such as Dandy-Walker variant, osteopenia, semi-flexed legs, and dermal pigmentation regions. Our data and the data from literature show that there are no specific clinical findings to define a r(10) syndrome.

  20. Department of Defense Base Structure Report Fiscal Year 2010 Baseline (A Summary of DoD’s Real Property Inventory)

    DTIC Science & Technology

    2010-01-01

    3,082 1,892Massachusetts Total: 70 397,970 Michigan 1Lt Robert L Poxon USARC Southfield 6 93,477 0 0 2626 24.9 599 14 2Army Reserve 0 0 Alpena County...Regional Airport Alpena 102 480,050 0 0 7100 262.8 253 0 0AF Guard 0 0 CTC Fort Custer Trng Center Augusta 137 639,470 0 0 7,5707,570 232.9 654 13...7,098,747 3 35,685 8,2344,747 2,902.7 5,176 2,067 0Massachusetts Total: 0 0 Michigan Alpena County Regional Airport Alpena 102 480,050 0 0 7100 262.8

  1. Amino Acids 257 to 288 of Mouse p48 Control the Cooperation of Polyomavirus Large T Antigen, Replication Protein A, and DNA Polymerase α-Primase To Synthesize DNA In Vitro

    PubMed Central

    Kautz, Armin R.; Weisshart, Klaus; Schneider, Annerose; Grosse, Frank; Nasheuer, Heinz-Peter

    2001-01-01

    Although p48 is the most conserved subunit of mammalian DNA polymerase α-primase (pol-prim), the polypeptide is the major species-specific factor for mouse polyomavirus (PyV) DNA replication. Human and murine p48 contain two regions (A and B) that show significantly lower homology than the rest of the protein. Chimerical human-murine p48 was prepared and coexpressed with three wild-type subunits of pol-prim, and four subunit protein complexes were purified. All enzyme complexes synthesized DNA on single-stranded (ss) DNA and replicated simian virus 40 DNA. Although the recombinant protein complexes physically interacted with PyV T antigen (Tag), we determined that the murine region A mediates the species specificity of PyV DNA replication in vitro. More precisely, the nonconserved phenylalanine 262 of mouse p48 is crucial for this activity, and pol-prim with mutant p48, h-S262F, supports PyV DNA replication in vitro. DNA synthesis on RPA-bound ssDNA revealed that amino acid (aa) 262, aa 266, and aa 273 to 288 are involved in the functional cooperation of RPA, pol-prim, and PyV Tag. PMID:11507202

  2. Recombination of an intrachromosomal paracentric insertion of chromosome 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Best, R.G.; Burnett, W.J.; Brock, J.K.

    1994-09-01

    Cytogenetic studies were initiated on a newborn female due to multiple congenital anomalies including microcephaly, clinodactyly, abnormal positioning of hands, left facial palsy, heart defect, sacral dimple, and facial dysmorphic features. Facial features were described as low set rotated ears, nystagmus, and a small, flattened nose. A structural rearrangement of the long arm of chromosome 3 was observed with a complex banding pattern. Study of parental chromosomes revealed a normal male pattern for the father, and an intrachromosomal insertion on the long arm of chromosome 3 for the mother described as 46,XX,dir ins(3)(q21q23q26.2). Further characterization of the proband`s structurally abnormalmore » chromosome 3 revealed a karyotype best described as: 46,XX,rec(3),dupq23{r_arrow}q26.2::q21{r_arrow}q23,dir ins(3)(q21q23q26.2), which is a partial duplication of both the inserted segment as well as the intervening segment between the inserted segment and the insertion site. This would appear to be the result of a three-strand double cross-over within the insertion loop. Molecular cytogenetic studies are presently underway to further elucidate chromosome structure of the proband and her mother.« less

  3. Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ClinicalTrials.gov

    2017-12-11

    Acute Biphenotypic Leukemia; Acute Erythroid Leukemia in Remission; Acute Leukemia in Remission; Acute Megakaryoblastic Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Acute Myeloid Leukemia in Remission; Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2); GATA2, MECOM; Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2); GATA2, MECOM; Acute Myeloid Leukemia With Multilineage Dysplasia; Acute Myeloid Leukemia With t(6;9) (p23;q34.1); DEK-NUP214; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Complete Remission; B Acute Lymphoblastic Leukemia With t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1); B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Burkitt Lymphoma; Childhood Acute Lymphoblastic Leukemia in Complete Remission; DS Stage II Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma; Myelodysplastic Syndrome; Recurrent Anaplastic Large Cell Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Hodgkin Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma; Secondary Acute Myeloid Leukemia; T Lymphoblastic Lymphoma

  4. OGLE-2003-BLG-262: Finite-Source Effects from a Point-Mass Lens

    NASA Astrophysics Data System (ADS)

    Yoo, Jaiyul; DePoy, D. L.; Gal-Yam, A.; Gaudi, B. S.; Gould, A.; Han, C.; Lipkin, Y.; Maoz, D.; Ofek, E. O.; Park, B.-G.; Pogge, R. W.; Mu-Fun Collaboration; Udalski, A.; Soszyński, I.; Wyrzykowski, Ł.; Kubiak, M.; Szymański, M.; Pietrzyński, G.; Szewczyk, O.; Żebruń, K.; OGLE Collaboration

    2004-03-01

    We analyze OGLE-2003-BLG-262, a relatively short (tE=12.5+/-0.1 day) microlensing event generated by a point-mass lens transiting the face of a K giant source in the Galactic bulge. We use the resulting finite-source effects to measure the angular Einstein radius, θE=195+/-17 μas, and so constrain the lens mass to the FWHM interval 0.08

  5. A procedural manual for measurement of uranium and thorium isotopes utilizing the USGS-Stanford Finnegan Mat 262

    USGS Publications Warehouse

    Shamp, Donald D.

    2001-01-01

    Over the past several decades investigators have extensively examined the 238U-234U- 230Th systematics of a variety of geologic materials using alpha spectroscopy. Analytical uncertainty for 230Th by alpha spectroscopy has been limited to about 2% (2σ). The advantage of thermal ionization mass spectroscopy (TIMS), introduced by Edwards and co-workers in the late 1980’s is the increased detectability of these isotopes by a factor of ~200, and decreases in the uncertainty for 230Th to about 5‰ (2σ) error. This report is a procedural manual for using the USGS-Stanford Finnegan-Mat 262 TIMS to collect and isolate Uranium and Thorium isotopic ratio data. Chemical separation of Uranium and Thorium from the sample media is accomplished using acid dissolution and then processed using anion exchange resins. The Finnegan-Mat262 Thermal Ionization Mass Spectrometer (TIMS) utilizes a surface ionization technique in which nitrates of Uranium and Thorium are placed on a source filament. Upon heating, positive ion emission occurs. The ions are then accelerated and focused into a beam which passes through a curved magnetic field dispersing the ions by mass. Faraday cups and/or an ion counter capture the ions and allow for quantitative analysis of the various isotopes.

  6. The conflict between cell proliferation and expansion primarily affects stem organogenesis in Arabidopsis.

    PubMed

    Maeda, Saori; Gunji, Shizuka; Hanai, Kenya; Hirano, Tomonari; Kazama, Yusuke; Ohbayashi, Iwai; Abe, Tomoko; Sawa, Shinichiro; Tsukaya, Hirokazu; Ferjani, Ali

    2014-11-01

    Plant shoot organs such as stems, leaves and flowers are derived from specialized groups of stem cells organized at the shoot apical meristem (SAM). Organogenesis involves two major processes, namely cell proliferation and differentiation, whereby the former contributes to increasing the cell number and the latter involves substantial increases in cell volume through cell expansion. Co-ordination between the above processes in time and space is essential for proper organogenesis. To identify regulatory factors involved in proper organogenesis, heavy-ion beam-irradiated de-etiolated (det) 3-1 seeds have been used to identify striking phenotypes in the A#26-2; det3-1 mutant. In addition to the stunted plant stature mimicking det3-1, the A#26-2; det3-1 mutant exhibited stem thickening, increased floral organ number and a fruit shape reminiscent of clavata (clv) mutants. DNA sequencing analysis demonstrated that A#26-2; det3-1 harbors a mutation in the CLV3 gene. Importantly, A#26-2; det3-1 displayed cracks that randomly occurred on the main stem with a frequency of approximately 50%. Furthermore, the double mutants clv3-8 det3-1, clv1-4 det3-1 and clv2-1 det3-1 consistently showed stem cracks with frequencies of approximately 97, 38 and 35%, respectively. Cross-sections of stems further revealed an increase in vascular bundle number, cell number and size in the pith of clv3-8 det3-1 compared with det3-1. These findings suggest that the stem inner volume increase due to clv mutations exerts an outward mechanical stress; that in a det3-1 background (defective in cell expansion) resulted in cracking of the outermost layer of epidermal cells. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  7. Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 are genomic markers for prognosis of advanced nasopharyngeal carcinoma.

    PubMed

    Sheu, Jim Jinn-Chyuan; Lee, Chia-Huei; Ko, Jenq-Yuh; Tsao, George S W; Wu, Chung-Chun; Fang, Chih-Yeu; Tsai, Fuu-Jen; Hua, Chun-Hung; Chen, Chi-Long; Chen, Jen-Yang

    2009-10-01

    Nasopharyngeal carcinoma is an epithelial malignancy with a remarkable racial and geographic distribution. Previous cytogenetic studies have shown nasopharyngeal carcinoma to be characterized by gross genomic aberrations. However, identification of susceptible gene loci in advanced nasopharyngeal carcinoma has been poorly discussed. A genome-wide survey of gene copy number changes was initiated with two nasopharyngeal carcinoma cell lines by array-based comparative genomic hybridization analysis. These alterations were confirmed by a parallel analysis with the data from the gene expression microarray and were validated by quantitative PCR. Clinical association of the defined target genes was analyzed by fluorescence in situ hybridization on 48 metastatic tumors. A high percentage of genes were consistently altered in dosage and expression levels with gain on 3q26.2-q26.32 and losses on 3p12.3-p14.2 and 9p21.3-p23. Six candidate genes, GPR160 (3q26.2-q27), SKIL (3q26), ADAMTS9 (3p14.2-p14.3), LRIG1 (3p14), MPDZ (9p22-p24), and ADFP (9p22.1) were validated by quantitative PCR. Fluorescence in situ hybridization studies revealed amplification of GPR160 (in 25% of cases) and SKIL (33%); and deletion of ADAMTS9 (30%), LRIG1 (35%), MPDZ (15%), and ADFP (15%). Clinical association analyses indicated a poor survival rate with genetic alterations at the defined 3p deletion (P = 0.0012) and the 3q amplification regions (P = 0.0114). The combined microarray technologies suggested novel candidate oncogenes, amplification of GPR160 and SKIL at 3q26.2-q26.32, and deletion of tumor suppressor genes ADAMTS9 and LRIG1 at 3p12.3-p14.2. Altered expression of these genes may be responsible for malignant progression and could be used as potential markers for nasopharyngeal carcinoma.

  8. Genetic Polymorphisms in SOD (rs2070424, rs7880) and CAT (rs7943316, rs1001179) Enzymes Are Associated with Increased Body Fat Percentage and Visceral Fat in an Obese Population from Central Mexico.

    PubMed

    Hernández-Guerrero, César; Hernández-Chávez, Paulina; Romo-Palafox, Inés; Blanco-Melo, Grecia; Parra-Carriedo, Alicia; Pérez-Lizaur, Ana

    2016-07-01

    Oxidative disturbance is an important factor involved in the etiology of comorbidities associated with obesity. Genetic polymorphisms such as SOD1 -251A>G, SOD2 47 C>T, CAT -21A>T and CAT -262 C>T have been described to alter the activity of antioxidant enzymes. The aim of the present work was to analyze the association of the mentioned SNPs with obesity and their relationship with anthropometric and clinical variables in this group. The study included 416 Mexican women (208 normal weight, NW and 208 subjects with obesity, OB). Dietary intake, anthropometric, biochemical and clinical features were evaluated and then analyzed in function of the genotypes. The mutated carriers (GA+GG) of SOD -251 were significantly higher in the OB group (0.24) compared to the NW group (0.08). The other SNPs showed no differences compared with control group. When comparing carrier mutated subjects with obesity vs. wild-type obese participants with the SNPs SOD1 -251, SOD2 47 and CAT -262, the carriers showed a significantly (p <0.05) higher value in body fat percentage. Also, carriers of SOD2 47 and CAT-262 showed significantly higher values (p = 0.002) and (p = 0.01), respectively, when visceral fat was compared between groups. Systolic blood pressure was significantly higher (p = 0.02) in carriers of mutated CAT-21. SOD1 -251A>G is associated with obesity independent of the presence of diabetes or dyslipidemia. Mutated obese carries of SOD1 -251, SOD2 47 and CAT -262 are associated with a higher distribution of fat in comparison with obese wild-type carriers. Copyright © 2016 IMSS. Published by Elsevier Inc. All rights reserved.

  9. Lesbian, Gay, Bisexual, and Transgender Patient Care: Medical Students' Preparedness and Comfort.

    PubMed

    White, William; Brenman, Stephanie; Paradis, Elise; Goldsmith, Elizabeth S; Lunn, Mitchell R; Obedin-Maliver, Juno; Stewart, Leslie; Tran, Eric; Wells, Maggie; Chamberlain, Lisa J; Fetterman, David M; Garcia, Gabriel

    2015-01-01

    Phenomenon: Lesbian, gay, bisexual, and transgender (LGBT) individuals face significant barriers in accessing appropriate and comprehensive medical care. Medical students' level of preparedness and comfort caring for LGBT patients is unknown. An online questionnaire (2009-2010) was distributed to students (n = 9,522) at 176 allopathic and osteopathic medical schools in Canada and the United States, followed by focus groups (2010) with students (n = 35) at five medical schools. The objective of this study was to characterize LGBT-related medical curricula, to determine medical students' assessments of their institutions' LGBT-related curricular content, and to evaluate their comfort and preparedness in caring for LGBT patients. Of 9,522 survey respondents, 4,262 from 170 schools were included in the final analysis. Most medical students (2,866/4,262; 67.3%) evaluated their LGBT-related curriculum as "fair" or worse. Students most often felt prepared addressing human immunodeficiency virus (HIV; 3,254/4,147; 78.5%) and non-HIV sexually transmitted infections (2,851/4,136; 68.9%). They felt least prepared discussing sex reassignment surgery (1,061/4,070; 26.1%) and gender transitioning (1,141/4,068; 28.0%). Medical education helped 62.6% (2,669/4,262) of students feel "more prepared" and 46.3% (1,972/4,262) of students feel "more comfortable" to care for LGBT patients. Four focus group sessions with 29 students were transcribed and analyzed. Qualitative analysis suggested students have significant concerns in addressing certain aspects of LGBT health, specifically with transgender patients. Insights: Medical students thought LGBT-specific curricula could be improved, consistent with the findings from a survey of deans of medical education. They felt comfortable, but not fully prepared, to care for LGBT patients. Increasing curricular coverage of LGBT-related topics is indicated with emphasis on exposing students to LGBT patients in clinical settings.

  10. 27 CFR 46.262 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... THE TREASURY (CONTINUED) TOBACCO MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held...

  11. 40 CFR 262.10 - Purpose, scope, and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... current hazardous waste accumulation areas Boston College, Chestnut Hill, MA 120 Chemistry, Biology..., Biology, Psychology, Anthropology, Geology and Earth Sciences, and Environmental, Coastal and Ocean...

  12. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... consist of Australia, Austria, Belgium, the Czech Republic, Denmark, Finland, France, Germany, Greece..., Portugal, the Republic of Korea, the Slovak Republic, Spain, Sweden, Switzerland, Turkey, the United...

  13. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... consist of Australia, Austria, Belgium, the Czech Republic, Denmark, Finland, France, Germany, Greece..., Portugal, the Republic of Korea, the Slovak Republic, Spain, Sweden, Switzerland, Turkey, the United...

  14. Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome.

    PubMed

    Pannone, Luca; Bocchinfuso, Gianfranco; Flex, Elisabetta; Rossi, Cesare; Baldassarre, Giuseppina; Lissewski, Christina; Pantaleoni, Francesca; Consoli, Federica; Lepri, Francesca; Magliozzi, Monia; Anselmi, Massimiliano; Delle Vigne, Silvia; Sorge, Giovanni; Karaer, Kadri; Cuturilo, Goran; Sartorio, Alessandro; Tinschert, Sigrid; Accadia, Maria; Digilio, Maria C; Zampino, Giuseppe; De Luca, Alessandro; Cavé, Hélène; Zenker, Martin; Gelb, Bruce D; Dallapiccola, Bruno; Stella, Lorenzo; Ferrero, Giovanni B; Martinelli, Simone; Tartaglia, Marco

    2017-04-01

    Germline mutations in PTPN11, the gene encoding the Src-homology 2 (SH2) domain-containing protein tyrosine phosphatase (SHP2), cause Noonan syndrome (NS), a relatively common, clinically variable, multisystem disorder. Here, we report on the identification of five different PTPN11 missense changes affecting residues Leu 261 , Leu 262 , and Arg 265 in 16 unrelated individuals with clinical diagnosis of NS or with features suggestive for this disorder, specifying a novel disease-causing mutation cluster. Expression of the mutant proteins in HEK293T cells documented their activating role on MAPK signaling. Structural data predicted a gain-of-function role of substitutions at residues Leu 262 and Arg 265 exerted by disruption of the N-SH2/PTP autoinhibitory interaction. Molecular dynamics simulations suggested a more complex behavior for changes affecting Leu 261 , with possible impact on SHP2's catalytic activity/selectivity and proper interaction of the PTP domain with the regulatory SH2 domains. Consistent with that, biochemical data indicated that substitutions at codons 262 and 265 increased the catalytic activity of the phosphatase, while those affecting codon 261 were only moderately activating but impacted substrate specificity. Remarkably, these mutations underlie a relatively mild form of NS characterized by low prevalence of cardiac defects, short stature, and cognitive and behavioral issues, as well as less evident typical facial features. © 2017 WILEY PERIODICALS, INC.

  15. Two novel families of plasmids from hyperthermophilic archaea encoding new families of replication proteins

    PubMed Central

    Soler, Nicolas; Marguet, Evelyne; Cortez, Diego; Desnoues, Nicole; Keller, Jenny; van Tilbeurgh, Herman; Sezonov, Guennadi; Forterre, Patrick

    2010-01-01

    Thermococcales (phylum Euryarchaeota) are model organisms for physiological and molecular studies of hyperthermophiles. Here we describe three new plasmids from Thermococcales that could provide new tools and model systems for genetic and molecular studies in Archaea. The plasmids pTN2 from Thermococcus nautilus sp. 30-1 and pP12-1 from Pyrococcus sp. 12-1 belong to the same family. They have similar size (∼12 kb) and share six genes, including homologues of genes encoded by the virus PAV1 from Pyrococcus abyssi. The plasmid pT26-2 from Thermococcus sp. 26-2 (21.5 kb), that corresponds to another plasmid family, encodes many proteins having homologues in virus-like elements integrated in several genomes of Thermococcales and Methanococcales. Our analyses confirm that viruses and plasmids are evolutionary related and co-evolve with their hosts. Whereas all plasmids previously isolated from Thermococcales replicate by the rolling circle mechanism, the three plasmids described here probably replicate by the theta mechanism. The plasmids pTN2 and pP12-1 encode a putative helicase of the SFI superfamily and a new family of DNA polymerase, whose activity was demonstrated in vitro, whereas pT26-2 encodes a putative new type of helicase. This strengthens the idea that plasmids and viruses are a reservoir of novel protein families involved in DNA replication. PMID:20403814

  16. 49 CFR 262.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION IMPLEMENTATION OF PROGRAM FOR CAPITAL GRANTS FOR RAIL LINE RELOCATION AND IMPROVEMENT PROJECTS.... Quality of life means the level of social, environmental and economic satisfaction and well being a...

  17. 21 CFR 26.2 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS, AND CERTAIN... determination of the equivalence of the regulatory systems of the parties, which is the cornerstone of this...

  18. 27 CFR 41.262 - Reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS AND TUBES, AND PROCESSED... this paragraph. (e) Concluding report. When a transfer of ownership of the business of an importer of...

  19. 24 CFR 203.262 - Due date of periodic MIP.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic...

  20. 24 CFR 203.262 - Due date of periodic MIP.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic...

  1. 25 CFR 262.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... contain such remains. (b) Sacred objects means specific ceremonial objects that are needed by traditional Indian religious leaders for the practice of traditional Indian religions by their present day adherents...

  2. 40 CFR 262.85 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or equivalent arrangements are valid for the purposes of this section only if persons assuming... paragraph (e): Financial guarantees so required are intended to provide for alternate recycling, disposal or...

  3. 8 CFR 264.1 - Registration and fingerprinting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Security, providing fingerprints, photographs, or submitting supplemental information or documentation. (ii... may be required and each change of material fact is a registration that is required under sections 262...

  4. 8 CFR 264.1 - Registration and fingerprinting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Security, providing fingerprints, photographs, or submitting supplemental information or documentation. (ii... may be required and each change of material fact is a registration that is required under sections 262...

  5. 49 CFR 262.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... financing instruments and costs incurred by the Grantee in performing project related audits, and includes.... Quality of life means the level of social, environmental and economic satisfaction and well being a...

  6. Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262

    DOE PAGES

    Kong, Leopold; Wilson, Ian A.; Kwong, Peter D.

    2014-12-26

    The crystal structure of a fully glycosylated HIV-1 gp120 core in complex with CD4 receptor and Fab 17b at 4.5-Å resolution reveals 9 of the 15 N-linked glycans of core gp120 to be partially ordered. The glycan at position Asn262 had the most extensive and well-ordered electron density, and a GlcNAc 2Man 7 was modeled. Lastly, the GlcNAc stem of this glycan is largely buried in a cleft in gp120, suggesting a role in gp120 folding and stability. Its arms interact with the stems of neighboring glycans from the oligomannose patch, which is a major target for broadly neutralizing antibodies.

  7. 40 CFR 262.87 - Reporting and recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Transfrontier Shipments of Hazardous Waste... Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460, no later than March 1 of each year...

  8. 49 CFR 262.7 - Eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... out for the purpose of mitigating the adverse effects of rail traffic on safety, motor vehicle traffic flow, community quality of life, or economic development; or (2) Involves a lateral or vertical...

  9. 49 CFR 262.7 - Eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... out for the purpose of mitigating the adverse effects of rail traffic on safety, motor vehicle traffic flow, community quality of life, or economic development; or (2) Involves a lateral or vertical...

  10. 49 CFR 262.7 - Eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... out for the purpose of mitigating the adverse effects of rail traffic on safety, motor vehicle traffic flow, community quality of life, or economic development; or (2) Involves a lateral or vertical...

  11. 49 CFR 262.7 - Eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... out for the purpose of mitigating the adverse effects of rail traffic on safety, motor vehicle traffic flow, community quality of life, or economic development; or (2) Involves a lateral or vertical...

  12. 12 CFR 262.2 - Procedure for regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... matter presented or ascertained, the appropriate division of the Board's staff, in collaboration with... the Legal Division, in collaboration with the other divisions of the staff. (d) Effective dates. Any...

  13. 12 CFR 262.2 - Procedure for regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... matter presented or ascertained, the appropriate division of the Board's staff, in collaboration with... the Legal Division, in collaboration with the other divisions of the staff. (d) Effective dates. Any...

  14. 27 CFR 41.262 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS AND TUBES, AND PROCESSED... is not required to report such shipment or transfer on TTB F 5250.2. (e) Concluding report. When a...

  15. 40 CFR 262.85 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... or equivalent arrangements are valid for the purposes of this section only if persons assuming... recycling, disposal or other means of sound management of the wastes in cases where arrangements for the...

  16. 40 CFR 262.85 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... or equivalent arrangements are valid for the purposes of this section only if persons assuming... recycling, disposal or other means of sound management of the wastes in cases where arrangements for the...

  17. 40 CFR 262.85 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... or equivalent arrangements are valid for the purposes of this section only if persons assuming... recycling, disposal or other means of sound management of the wastes in cases where arrangements for the...

  18. 40 CFR 262.85 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... or equivalent arrangements are valid for the purposes of this section only if persons assuming... recycling, disposal or other means of sound management of the wastes in cases where arrangements for the...

  19. 8 CFR 264.1 - Registration and finger-printing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Security, providing fingerprints, photographs, or submitting supplemental information or documentation. (ii... may be required and each change of material fact is a registration that is required under sections 262...

  20. Violent Content Research Act of 2013

    THOMAS, 113th Congress

    Sen. Rockefeller, John D., IV [D-WV

    2013-01-24

    Senate - 12/17/2013 Placed on Senate Legislative Calendar under General Orders. Calendar No. 262. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. 76 FR 39085 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ..., July 05, 2011. Docket Numbers: RP11-2205-000. Applicants: Venice Gathering System, LLC. Description: Venice Gathering System, LLC submits tariff filing per 154.203: Section 26.2 Suspension of Reservation...

  2. 28 CFR 34.100 - Purpose and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 262(d)(2) of the Juvenile Justice and Delinquency Prevention Act of 1974, as amended. This provision... proposed program. (b) This subpart of the regulation applies to all applications for grants, cooperative...

  3. 25 CFR 141.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... part is to prescribe rules for the regulation of reservation businesses for the protection of Indian consumers on the Navajo, Hopi and Zuni Reservations as required by 25 U.S.C. 261, 262, 263, and 264. ...

  4. 25 CFR 262.5 - Application for permits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... either state that no religious or cultural site will be harmed or destroyed by the proposed work or... similar condition: “Human remains of Indians, funerary objects, sacred objects, and objects of cultural...

  5. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.

    PubMed

    Elvira, George; Massie, Bernard; DesGroseillers, Luc

    2006-01-01

    In mammalian neurons, transport and translation of mRNA to individual potentiated synapses is believed to occur via a heterogeneous population of RNA granules. To identify components of Staufen2-containing granules, we used the yeast two-hybrid system. A mouse fetal cDNA library was screened with the N-terminal fragment of Staufen2 as bait. ZFR, a three zinc finger protein, was identified as an interacting protein. Confocal microscopy showed that ZFR, although mainly nuclear, was also found in the somatodendritic compartment of primary hippocampal neurons where it localized as granule-like structures. Co-localization with Staufen2 was observed in several granules. Biochemical analyses (immunoprecipitation, cell fractionation) further confirmed the ZFR/Staufen2 association. ZFR was shown to interact with at least the Staufen2(62) isoform, but not with Staufen1. ZFR also co-fractionated with ribosomes and Staufen2(59) and Staufen2(52) in a sucrose gradient. Interestingly, knockdown expression of ZFR through RNA interference in neurons relocated specifically the Staufen2(62), but not the Staufen2(59), isoform to the nucleus. Our results demonstrate that ZFR is a native component of Staufen2-containing granules and likely plays its role during early steps of RNA transport and localization. They also suggest that one of these roles may be linked to Staufen2(62)-containing RNA granule formation in the nucleus and/or to their nucleo-cytoplasmic shuttling.

  6. Congenital hypoplastic bone marrow failure associated with a de novo partial deletion of the MECOM gene at 3q26.2.

    PubMed

    Kjeldsen, Eigil; Veigaard, Christopher; Aggerholm, Anni; Hasle, Henrik

    2018-05-20

    Congenital hypoplastic bone marrow failure is a rare condition in neonates. The genetics and mechanisms behind are largely obscure. Here we characterize a neonate presenting with congenital thrombocytopenia and anemia. During the first 2-4 weeks after birth the neonate developed severe neutropenia while the lymphoid lineages were unaffected. The neonate was without dysmorphic signs. A de novo mono-allelic constitutional microdeletion of 175.1 kb at 3q26.2 affecting exon 2 of MECOM, involving MDS1 but not EVI1, was identified as the only copy number alteration by oligo-based array-CGH analysis. Expression analysis showed profoundly reduced expression of multiple MECOM transcripts in the bone marrow cells. Whole exome sequencing detected no pathogenic mutations in genes known to be associated with inherited bone marrow failure syndromes. The patient was successfully treated with hematopoietic stem cell transplantation at 5 months of age. Interstitial deletions encompassing the 3q26.2 region are very rare. A literature search revealed two previous cases with microdeletions involving this region, and the cases were associated with congenital thrombocytopenia and anemia, but unaffected lymphopoiesis. Together these data indicate that MECOM may be important for normal myeloid hematopoiesis in humans but dispensable for lymphoid differentiation. We suggest that partial deletion in MECOM may be a primary event associated with congenital pancytopenia. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Paycheck Fairness Act

    THOMAS, 113th Congress

    Sen. Mikulski, Barbara A. [D-MD

    2014-04-01

    Senate - 09/15/2014 Cloture on the bill not invoked in Senate by Yea-Nay Vote. 52 - 40. Record Vote Number: 262. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. 77 FR 69723 - Federal Acquisition Regulation; Free Trade Agreement-Panama

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ...,777,000 Bahrain FTA 202,000 202,000 10,074,262 CAFTA-DR (Costa Rica, Dominican Republic, El Salvador... Republic, El Salvador, Guatemala, Honduras, Korea (Republic of), Mexico, Morocco, Nicaragua, Oman, Panama...

  9. Workforce Democracy and Fairness Act

    THOMAS, 112th Congress

    Rep. Kline, John [R-MN-2

    2011-10-05

    Senate - 12/16/2011 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 262. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  10. 29 CFR 452.95 - Absentee ballots.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ballots. 46 45 Goldberg v. Marine Cooks and Stewards Union, 204 F. Supp. 844 (N.D. Cal. 1962). 46 Wirtz v. Local Union 262, Glass Bottle Blowers Association, 290 F. Supp. 965 (N.D. Calif. 1968). ...

  11. 29 CFR 452.95 - Absentee ballots.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ballots. 46 45 Goldberg v. Marine Cooks and Stewards Union, 204 F. Supp. 844 (N.D. Cal. 1962). 46 Wirtz v. Local Union 262, Glass Bottle Blowers Association, 290 F. Supp. 965 (N.D. Calif. 1968). ...

  12. 29 CFR 452.95 - Absentee ballots.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ballots. 46 45 Goldberg v. Marine Cooks and Stewards Union, 204 F. Supp. 844 (N.D. Cal. 1962). 46 Wirtz v. Local Union 262, Glass Bottle Blowers Association, 290 F. Supp. 965 (N.D. Calif. 1968). ...

  13. 29 CFR 452.95 - Absentee ballots.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ballots. 46 45 Goldberg v. Marine Cooks and Stewards Union, 204 F. Supp. 844 (N.D. Cal. 1962). 46 Wirtz v. Local Union 262, Glass Bottle Blowers Association, 290 F. Supp. 965 (N.D. Calif. 1968). ...

  14. 29 CFR 452.95 - Absentee ballots.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ballots. 46 45 Goldberg v. Marine Cooks and Stewards Union, 204 F. Supp. 844 (N.D. Cal. 1962). 46 Wirtz v. Local Union 262, Glass Bottle Blowers Association, 290 F. Supp. 965 (N.D. Calif. 1968). ...

  15. 11. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 INTERIOR DETAIL OF FRAME CONSTRUCTION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  16. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... management of laboratory wastes and from the reuse, recycling or disposal of such materials outside the... for the purpose of supporting continual improvement of the Environmental Management Plan. (iii...

  17. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... management of laboratory wastes and from the reuse, recycling or disposal of such materials outside the... for the purpose of supporting continual improvement of the Environmental Management Plan. (iii...

  18. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... management of laboratory wastes and from the reuse, recycling or disposal of such materials outside the... for the purpose of supporting continual improvement of the Environmental Management Plan. (iii...

  19. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... management of laboratory wastes and from the reuse, recycling or disposal of such materials outside the... for the purpose of supporting continual improvement of the Environmental Management Plan. (iii...

  20. 33 CFR 106.262 - Security measures for newly-hired employees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... following information on the new hire into the Coast Guard's Homeport Web site (http://homeport.uscg.mil): (i) Full legal name, including middle name if one exists; (ii) Date of birth; (iii) Social security...

  1. 33 CFR 106.262 - Security measures for newly-hired employees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... following information on the new hire into the Coast Guard's Homeport Web site (http://homeport.uscg.mil): (i) Full legal name, including middle name if one exists; (ii) Date of birth; (iii) Social security...

  2. 24 CFR 26.2 - Hearing officer, powers, and duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the interests of justice may require; (5) To regulate the course of the hearing and the conduct of the... consent of the parties; (7) To consider and rule upon all procedural and other motions appropriate in...

  3. 24 CFR 26.2 - Hearing officer, powers, and duties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the interests of justice may require; (5) To regulate the course of the hearing and the conduct of the... consent of the parties; (7) To consider and rule upon all procedural and other motions appropriate in...

  4. 24 CFR 26.2 - Hearing officer, powers, and duties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the interests of justice may require; (5) To regulate the course of the hearing and the conduct of the... consent of the parties; (7) To consider and rule upon all procedural and other motions appropriate in...

  5. 24 CFR 26.2 - Hearing officer, powers, and duties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the interests of justice may require; (5) To regulate the course of the hearing and the conduct of the... consent of the parties; (7) To consider and rule upon all procedural and other motions appropriate in...

  6. 24 CFR 26.2 - Hearing officer, powers, and duties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the interests of justice may require; (5) To regulate the course of the hearing and the conduct of the... consent of the parties; (7) To consider and rule upon all procedural and other motions appropriate in...

  7. Information for Exporters of Resource Conservation and Recovery Act (RCRA) Hazardous Waste

    EPA Pesticide Factsheets

    Information for exporters of hazardous waste to OECD countries for recycling who are subject to the hazardous waste generator and importer requirements described in 40 CFR Part 262 Subpart H, under RCRA

  8. Belly Fat in Men: Why Weight Loss Matters

    MedlinePlus

    ... amount of belly fat increases your risk of: Cardiovascular disease Insulin resistance and type 2 diabetes Colorectal cancer ... 61:262. Carlsson AC, et al. Prediction of cardiovascular disease by abdominal obesity measures is dependent on body ...

  9. 39 CFR 262.2 - Officials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... ensure that record management practices are in compliance with the Privacy Act and FOIA. The Manager... postal facilities. (d) Information System Executive. The Postal Service official who prescribes the...

  10. 39 CFR 262.2 - Officials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... ensure that record management practices are in compliance with the Privacy Act and FOIA. The Manager... postal facilities. (d) Information System Executive. The Postal Service official who prescribes the...

  11. 39 CFR 262.2 - Officials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... ensure that record management practices are in compliance with the Privacy Act and FOIA. The Manager... postal facilities. (d) Information System Executive. The Postal Service official who prescribes the...

  12. 39 CFR 262.2 - Officials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... ensure that record management practices are in compliance with the Privacy Act and FOIA. The Manager... postal facilities. (d) Information System Executive. The Postal Service official who prescribes the...

  13. 39 CFR 262.2 - Officials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... ensure that record management practices are in compliance with the Privacy Act and FOIA. The Manager... postal facilities. (d) Information System Executive. The Postal Service official who prescribes the...

  14. Complement

    MedlinePlus

    ... activity (CH50, CH100) looks at the overall activity of the complement system. In most cases, other tests that are more ... Church SE, Fremeaux-Bacchi V, Roumenina LT. Complement system part I - molecular mechanisms of activation and regulation. Front Immunol . 2015;6:262. ...

  15. Detection of a large increase of the size of the Be disk from the X-ray binary A 0535+262

    NASA Astrophysics Data System (ADS)

    Camero-Arranz, A.; Ozbey-Arabaci, M.; Fabregat, J.; Gutierrez-Soto, J.; Finger, Mark H.; Peris, V.; Brevia, O.

    2014-04-01

    We report on the evolution of the H & alpha; equivalent width (EW) of the Be/X-ray binary system A 0535+262/HD 245770, using observations performed with the spectrograph Albireo, at the 1.5 m telescope of the Observatorio de Sierra Nevada (Granada, Spain) on 2012-03-26 22:27:59.000 UTC (MJD 56012.936), and recently with the spectrograph located at the 51 cm telescope of the Observatorio de Aras de los Olmos of the University of Valencia on 2014-Mar-07 at 21:07:00.000 UTC (MJD 56723.879), and also with the TFOSC spectrometer at the 1.5 m telescope RTT150 of the T & Uuml;B & #304TAK National Observatory (Antalya, Turkey) on 2014-03-18 19:57:14.688 UTC (MJD 56734.831) and 2014-03-19 19:58:30.746 UTC (MJD 56735.832). ...

  16. Navy Career Sea Pay: Is it Still a Viable Compensating Wage Program? A Historical and Financial Analysis

    DTIC Science & Technology

    2007-06-01

    220 | E7 5 262 | E7 5 468 | E7 6 118 | E7 6 147 | E7 6 267 | E7 7 17 | E7 7 37 | E7 7 81 | E8 1 61 | E8 1 64 | E8 1 57 | E8 2 62 | E8 2 76 | E8 2 70...5027 4923 4932 4640 E7-E9 451 405 387 445 447 462 453 454 448 441 441 489 MA E1-E3 1 1 1 2 12 22 33 108 135 137 160 189 E4-E6 429 414 407 416 444 483...20 262 12 24 970 8 4.60% 5.80% 1.33% 60.00% 1.60% 33.33% Apr-03 1593 10 342 4 42 467 15 26 1023 11 0.63% 40.00% 2.64% 35.71% 1.63% 42.31% Oct-03 1711

  17. Hierarchical Address Event Routing for Reconfigurable Large-Scale Neuromorphic Systems.

    PubMed

    Park, Jongkil; Yu, Theodore; Joshi, Siddharth; Maier, Christoph; Cauwenberghs, Gert

    2017-10-01

    We present a hierarchical address-event routing (HiAER) architecture for scalable communication of neural and synaptic spike events between neuromorphic processors, implemented with five Xilinx Spartan-6 field-programmable gate arrays and four custom analog neuromophic integrated circuits serving 262k neurons and 262M synapses. The architecture extends the single-bus address-event representation protocol to a hierarchy of multiple nested buses, routing events across increasing scales of spatial distance. The HiAER protocol provides individually programmable axonal delay in addition to strength for each synapse, lending itself toward biologically plausible neural network architectures, and scales across a range of hierarchies suitable for multichip and multiboard systems in reconfigurable large-scale neuromorphic systems. We show approximately linear scaling of net global synaptic event throughput with number of routing nodes in the network, at 3.6×10 7 synaptic events per second per 16k-neuron node in the hierarchy.

  18. Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant.

    PubMed

    Fernandes da Costa, Sérgio P; Mot, Dorien; Geeraerts, Sofie; Bokori-Brown, Monika; Van Immerseel, Filip; Titball, Richard W

    2016-06-01

    Necrotic enteritis toxin B (NetB) is a pore-forming toxin produced by Clostridium perfringens and has been shown to play a key role in avian necrotic enteritis, a disease causing significant costs to the poultry production industry worldwide. The aim of this work was to determine whether immunization with a non-toxic variant of NetB (NetB W262A) and the C-terminal fragment of C. perfringens alpha-toxin (CPA247-370) would provide protection against experimental necrotic enteritis. Immunized birds with either antigen or a combination of antigens developed serum antibody levels against NetB and CPA. When CPA247-370 and NetB W262A were used in combination as immunogens, an increased protection was observed after oral challenge by individual dosing, but not after in-feed-challenge.

  19. Comment on `A novel experimental method: Electrochemical detection of phase transition in ferroelectric single crystals', Chem. Phys. Lett. 384 (2004) 262 by K. Gatner and R. Jakubas

    NASA Astrophysics Data System (ADS)

    Ćwikiel, K.; Matlak, M.

    2006-03-01

    We comment the Letter 'A novel experimental method: electrochemical detection of phase transition in ferroelectric single crystals', Chem. Phys. Lett. 384 (2004) 262 by K. Gatner and R. Jakubas. We indicate that the method used in this Letter is not 'A novel method' but the application of the method described in Refs. [M. Matlak, M. Pietruszka, E. Rówiński, Phys. Rev. B 63 (2001) 52101; M. Matlak, M. Pietruszka, E. Rówiński, Phys. Stat. Sol. A 184 (2001) 335; W. Gaweł, E. Zaleska, Z. Sztuba, Met. Sci. Eng. A 324 (2002) 255], well known to Gatner, but not cited in the commented Letter. Additionally Gatner, cooperating with us, has used our TGS samples and published the results in the commented Letter without our knowledge and permission.

  20. Carbon-hydrogen-related complexes in Si

    NASA Astrophysics Data System (ADS)

    Kolkovsky, Vl.; Stübner, R.; Gwozdz, K.; Weber, J.

    2018-04-01

    Several deep level transient spectroscopy (DLTS) peaks (E42, E65, E75, E90, E262, and H180) are observed in n- and p-type Czochralski-grown Si samples subjected to hydrogenation by a dc H plasma treatment. The concentration of the defects is found to be proportional to the carbon and hydrogen content in our samples. The analysis of the depth profiles performed in Si samples hydrogenated by wet chemically etching shows that all these defects contain a single H atom. E65 and E75 appear only in samples with a high oxygen content which shows that oxygen is a constituent of these defects. The analysis of the enhancement of the emission rate of the defects with electric field shows that E65, E75, E90, and E262 are single acceptors whereas E42 is a double acceptor. The presence of a barrier for hole capture (about 53 meV) can explain the absence of the enhancement of the emission rate of H180, which can be attributed to a single acceptor state. From a comparison with theory, we assign E90 to CH1BC, E42 (E262) to CH1AB, and H180 to CH1Td. The similarity of the electrical properties of E65 and E75 to those of E90 suggest that E65 and E75 may originate from the CH1BC defect with an oxygen atom in its nearest neighborhood. Our results on the CH-related complexes give a conclusive explanation of some previously reported controversial experimental data.

  1. Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer.

    PubMed

    Jamhiri, Iman; Saadat, Iraj; Omidvari, Shahpour

    2017-06-01

    Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles can be established as risk factors for some kind of multi-factorial diseases including cancer. In present study we investigate the possible association between polymorphisms of superoxide dismutase 1 ( SOD1 , OMIM: 147450) and catalase ( CAT , OMIM: 115500) genes and the risk of colorectal cancer (CRC). The study included 204 colorectal cancer patients and 239 healthy control group matched for gender and age. Genotyping of SOD1 A251G and CAT C-262T were done by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. There was no significant association between CAT C-262T polymorphism and susceptibility to CRC (P>0.05). The carries of the G allele of SOD1 significantly showed higher prevalence in CRC patients compared with the control group (OR=1.84, 95% CI=1.13-2.98, P=0.013). We assessed the effect of combination of genotypes of the study polymorphisms on the risk of CRC. We found that the combination of AG+GG ( SOD1 ) and CC ( CAT ) increases the risk of developing CRC (OR=2.38, 95% CI=1.25-4.52, P=0.008).

  2. Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer

    PubMed Central

    Jamhiri, Iman; Saadat, Iraj; Omidvari, Shahpour

    2017-01-01

    Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles can be established as risk factors for some kind of multi-factorial diseases including cancer. In present study we investigate the possible association between polymorphisms of superoxide dismutase 1 (SOD1, OMIM: 147450) and catalase (CAT, OMIM: 115500) genes and the risk of colorectal cancer (CRC). The study included 204 colorectal cancer patients and 239 healthy control group matched for gender and age. Genotyping of SOD1 A251G and CAT C-262T were done by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. There was no significant association between CAT C-262T polymorphism and susceptibility to CRC (P>0.05). The carries of the G allele of SOD1 significantly showed higher prevalence in CRC patients compared with the control group (OR=1.84, 95% CI=1.13-2.98, P=0.013). We assessed the effect of combination of genotypes of the study polymorphisms on the risk of CRC. We found that the combination of AG+GG (SOD1) and CC (CAT) increases the risk of developing CRC (OR=2.38, 95% CI=1.25-4.52, P=0.008). PMID:28775994

  3. Five-year analysis of rickettsial fevers in children in South India: Clinical manifestations and complications.

    PubMed

    Thomas, Rwituja; Puranik, Preeti; Kalal, Bhuvanesh; Britto, Carl; Kamalesh, Savitha; Rego, Sylvan; Shet, Anita

    2016-06-30

    Rickettsial infections are re-emerging in the Indian subcontinent, especially among children. Understanding geographical and clinical epidemiology will facilitate early diagnosis and management. Children aged <18yrs hospitalized with clinically-diagnosed rickettsial fever were reviewed retrospectively. Frequency distributions and odds ratios were calculated from tabulated data. Among 262 children hospitalized between January 2008-December 2012, median age was five years, and 61% were male children. Hospitalized cases increased steadily every year, with the highest burden (74%) occurring between September and January each year. Mean duration of fever was 11.5 days. Rash was present in 54.2% (142/262) of children, with 37.0% involving palms and soles. Prevalence of malnutrition was high (45% of children were underweight and 28% had stunting). Retinal vasculitis was seen in 13.7% (36/262), and the risk appeared higher in females. Severe complications were seen in 29% (purpura fulminans, 7.6%; meningitis and meningoencephalitis, 28%; septic shock, 1.9%; acute respiratory distress syndrome, 1.1%). Complications were more likely to occur in anemic children. Positive Weil-Felix test results (titers ≥1:160) were seen in 70% of cases. Elevated OX-K titers suggestive of scrub typhus were seen in 80% (147/184). Patients were treated with chloramphenicol (32%) or doxycycline (68%). Overall mortality among hospitalised children was 1.9%. This five-year analysis from southern India shows a high burden and increasing trend of rickettsial infections among children. The occurrence of retinal vasculitis and a high rate of severe complications draw attention to the need for early diagnosis and management of these infections.

  4. Nanosized insulin-complexes based on biodegradable amine-modified graft polyesters poly[vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(L-lactic acid): protection against enzymatic degradation, interaction with Caco-2 cell monolayers, peptide transport and cytotoxicity.

    PubMed

    Simon, Michael; Behrens, Isabel; Dailey, Lea Anne; Wittmar, Matthias; Kissel, Thomas

    2007-05-01

    Non-parenteral insulin delivery by the oral route is limited by epithelial barriers and enzymatic degradation. Nanosized insulin-complexes based on amine modified comb-like polyesters were designed to overcome these barriers. Protection of insulin in nanocomplexes (NC) from enzymatic degradation was investigated. The interaction with enterocyte-like Caco-2 cells in terms of cytotoxicity, transport through and uptake in the cell layers was evaluated by measuring transepithelial electrical resistance (TEER), release of lactate dehydrogenase (LDH) and insulin transport. The protection capacity of NC and their interaction with Caco-2 cells varied strongly as a function of lactide-grafting (hydrophobicity). With increasing lactide-grafting (P(26) < or = P(26)-1(LL) < or = P(26)-2(LL)) NC protected up to 95% of the insulin against degradation by trypsin. Transport and uptake into cell monolayers increased with higher l-lactid grafting. About 25% of a 1.25mg/ml TRITC-insulin NC dispersion with P(26)-2(LL) was recovered in Caco-2 cells after 90 min. A concentration dependent cytotoxicity profile was observed showing elevated LDH release and decreased TEER values. The cytotoxicity correlates with the surfactant like character of the polymers, decreasing the surface tension to 46 mN/m for the amphiphilic P(26)-2(LL). The observed TEER decrease was reversible after 20 h, suggesting that the biodegradable comb-polyesters offer a promising approach to overcome mucosal barriers.

  5. 40 CFR 262.23 - Use of the manifest.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... generation, the generator must send at least three copies of the manifest dated and signed in accordance with....72(f)), the generator must: (1) Sign either: (i) Item 20 of the new manifest if a new manifest is...

  6. 40 CFR 262.207 - Training.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative Requirements for Hazardous Waste Determination and... experiment; or (2) Formal classroom training; or (3) Electronic/written training; or (4) On-the-job training...

  7. 40 CFR 262.207 - Training.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative Requirements for Hazardous Waste Determination and... experiment; or (2) Formal classroom training; or (3) Electronic/written training; or (4) On-the-job training...

  8. 40 CFR 262.90 - Project XL for Public Utilities in New York State.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... section including, but not limited to, the following: (1) Database management for each remote location as... consolidation of waste for economical shipment (including no longer shipping waste directly to a TSD from remote...

  9. 40 CFR 262.90 - Project XL for Public Utilities in New York State.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... section including, but not limited to, the following: (1) Database management for each remote location as... consolidation of waste for economical shipment (including no longer shipping waste directly to a TSD from remote...

  10. 40 CFR 262.90 - Project XL for Public Utilities in New York State.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... section including, but not limited to, the following: (1) Database management for each remote location as... consolidation of waste for economical shipment (including no longer shipping waste directly to a TSD from remote...

  11. 40 CFR 262.90 - Project XL for Public Utilities in New York State.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... section including, but not limited to, the following: (1) Database management for each remote location as... consolidation of waste for economical shipment (including no longer shipping waste directly to a TSD from remote...

  12. 49 CFR 262.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., including architectural and engineering costs, and costs associated with compliance with the National.... Allowable costs means those project costs for which Federal funding may be expended under this part. Only construction and construction-related costs will be allowable. Construction means supervising, inspecting...

  13. 49 CFR 262.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., including architectural and engineering costs, and costs associated with compliance with the National.... Allowable costs means those project costs for which Federal funding may be expended under this part. Only construction and construction-related costs will be allowable. Construction means supervising, inspecting...

  14. 49 CFR 262.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., including architectural and engineering costs, and costs associated with compliance with the National.... Allowable costs means those project costs for which Federal funding may be expended under this part. Only construction and construction-related costs will be allowable. Construction means supervising, inspecting...

  15. 8. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 BRICK NOGGING AND ORIGINAL WEATHERBOARDING OF SOUTH ELEVATION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  16. Training Evaluation: Clients' Roles.

    ERIC Educational Resources Information Center

    Hashim, Junaidah

    2001-01-01

    A study was conducted of 262 training providers in Malaysia, where providers must be government approved. Government regulation, client demands for high quality, and an economic downturn that focused attention on training costs have all influenced evaluation in a positive direction. (SK)

  17. [Polymorphisms of inhibin α gene exon 1 in buffalo (Bubalus bubalis), gayal (Bos frontalis) and yak (Bos grunniens)].

    PubMed

    Miao, Yong-Wang; Ha, Fu; Gao, Hua-Shan; Yuan, Feng; Li, Da-Lin; Yuan, Yue-Yun

    2012-08-01

    To elucidate the genetic characteristics of the bovine Inhibin α subunit (INHA) gene, the polymorphisms in exon 1 of INHA and its bilateral sequences were assayed using PCR with direct sequencing in buffalo, gayal and yak. A comparative analysis was conducted by pooled the results in this study with the published data of INHA on some mammals including some bovine species together. A synonymous substitution c.73C>A was identified in exon 1 of INHA for buffalo, which results in identical encoding product in river and swamp buffalo. In gayal, two non-synonymous but same property substitutions in exon 1 of INHA, viz. c.62 C>T and c.187 G>A, were detected, which lead to p. P21L, p. V63M changes in INHA, respectively. In yak, nucleotide substitution c.62C> T, c.129A>G were found in exon 1 of INHA, the former still causes p. P21L substitution and the latter is synonymous. For the sequence of the 5'-flanking region of INHA examined, no SNPs were found within the species, but a substitution, c. -6T>G, was found. The nucleotide in this site in gayal, yak and cattle was c. -6G, whereas in buffalo it was c. -6T. Meanwhile, a 6-bp deletion, namely c. 262+31_262+36delTCTGAC, was found in the intron of buffalo INHA gene. For this deletion, wild types (+/+) account for main part in river buffalo while mutant types (-/-) are predominant in swamp buffalo. This deletion was not found in gayal, yak and cattle, though these all have another deletion in the intron of INHA, c. 262+78_262+79delTG. The results of sequence alignment showed that the substitutions c. 43A and c. 67G in exon 1 of INHA are specific to buffalo, whereas the substitutions c. 173A and c. 255G are exclusive to gayal, yak and cattle, and c. 24C, c. 47G, c. 174T and c. 206T are specific to goat. Furthermore, there are few differences among gayal, yak and cattle, but there relatively great differences between buffalo, goat and other bovine species regarding the sequences of INHA exon 1.

  18. Frequent Questions about the Manifest Registry

    EPA Pesticide Factsheets

    FAQs Including Can I submit multiple form samples to the EPA Registry for approval? Must I submit a continuation sheet sample to the Manifest Registry under section 262.21(d)? Can I typeset the form after I am approved to print the manifest?

  19. Respiratory Plasticity Following Spinal Injury: Role of Chloride-Dependent Inhibitory Neurotransmission

    DTIC Science & Technology

    2016-12-01

    respiratory pathways following spinal cord injury. J Appl Physiol. 94(2):795-810. Raineteau O and Schwab ME (2001). Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci. 2(4):262-73. APPENDICES : None

  20. 40 CFR 180.262 - Ethoprop; tolerances for residues.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., succulent 0.02 Cabbage 0.02 Corn, field, forage 0.02 Corn, field, grain 0.02 Corn, field, stover 0.02 Corn, sweet, forage 0.02 Corn, sweet, kernel plus cob with husks removed 0.02 Corn, sweet, stover 0.02...

  1. 40 CFR 180.262 - Ethoprop; tolerances for residues.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., succulent 0.02 Cabbage 0.02 Corn, field, forage 0.02 Corn, field, grain 0.02 Corn, field, stover 0.02 Corn, sweet, forage 0.02 Corn, sweet, kernel plus cob with husks removed 0.02 Corn, sweet, stover 0.02...

  2. 40 CFR 180.262 - Ethoprop; tolerances for residues.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., succulent 0.02 Cabbage 0.02 Corn, field, forage 0.02 Corn, field, grain 0.02 Corn, field, stover 0.02 Corn, sweet, forage 0.02 Corn, sweet, kernel plus cob with husks removed 0.02 Corn, sweet, stover 0.02...

  3. 40 CFR 180.262 - Ethoprop; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., succulent 0.02 Cabbage 0.02 Corn, field, forage 0.02 Corn, field, grain 0.02 Corn, field, stover 0.02 Corn, sweet, forage 0.02 Corn, sweet, kernel plus cob with husks removed 0.02 Corn, sweet, stover 0.02...

  4. 40 CFR 262.83 - Notification and consent.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Transfrontier Shipments of Hazardous Waste...), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460, with the words “Attention... (2254A), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460, with the...

  5. Figure_2_data

    EPA Pesticide Factsheets

    Data for Figure 2This dataset is associated with the following publication:Sarwar, G., D. Kang, K. Foley, D. Schwede, B. Gantt, and R. Mathur. Technical note: Examining ozone deposition over seawater. ATMOSPHERIC ENVIRONMENT. Elsevier Science Ltd, New York, NY, USA, 141: 255–262, (2016).

  6. 39 CFR 262.5 - Systems (Privacy).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... information about individuals, including mailing lists, from which information is retrieved by the name of an... Management and Budget, and these regulations. The term “matching program” includes any computerized...

  7. 39 CFR 262.5 - Systems (Privacy).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... information about individuals, including mailing lists, from which information is retrieved by the name of an... Management and Budget, and these regulations. The term “matching program” includes any computerized...

  8. 39 CFR 262.5 - Systems (Privacy).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... information about individuals, including mailing lists, from which information is retrieved by the name of an... Management and Budget, and these regulations. The term “matching program” includes any computerized...

  9. 39 CFR 262.5 - Systems (Privacy).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT... information about individuals, including mailing lists, from which information is retrieved by the name of an... Management and Budget, and these regulations. The term “matching program” includes any computerized...

  10. 40 CFR 262.10 - Purpose, scope, and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and Life Sciences, Arts and Sciences, Medicine, and Engineering and Mathematics; and Schools of..., Biology, Psychology, Anthropology, Geology and Earth Sciences, and Environmental, Coastal and Ocean Sciences Science Building (Bldg. #080); McCormack Building (Bldg. #020); and Wheatley Building (Bldg. #010...

  11. 40 CFR 262.10 - Purpose, scope, and applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and Life Sciences, Arts and Sciences, Medicine, and Engineering and Mathematics; and Schools of..., Biology, Psychology, Anthropology, Geology and Earth Sciences, and Environmental, Coastal and Ocean Sciences Science Building (Bldg. #080); McCormack Building (Bldg. #020); and Wheatley Building (Bldg. #010...

  12. 40 CFR 262.10 - Purpose, scope, and applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and Life Sciences, Arts and Sciences, Medicine, and Engineering and Mathematics; and Schools of..., Biology, Psychology, Anthropology, Geology and Earth Sciences, and Environmental, Coastal and Ocean Sciences Science Building (Bldg. #080); McCormack Building (Bldg. #020); and Wheatley Building (Bldg. #010...

  13. 40 CFR 262.10 - Purpose, scope, and applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and Life Sciences, Arts and Sciences, Medicine, and Engineering and Mathematics; and Schools of..., Biology, Psychology, Anthropology, Geology and Earth Sciences, and Environmental, Coastal and Ocean Sciences Science Building (Bldg. #080); McCormack Building (Bldg. #020); and Wheatley Building (Bldg. #010...

  14. 40 CFR 262.101 - What is in this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... definitions that apply to the University laboratories. It contains specific requirements for how to handle... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project... framework for a new management system for wastes that are generated in University laboratories. This...

  15. 40 CFR 262.101 - What is in this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... definitions that apply to the University laboratories. It contains specific requirements for how to handle... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project... framework for a new management system for wastes that are generated in University laboratories. This...

  16. 40 CFR 262.101 - What is in this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... definitions that apply to the University laboratories. It contains specific requirements for how to handle... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project... framework for a new management system for wastes that are generated in University laboratories. This...

  17. 40 CFR 262.101 - What is in this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... definitions that apply to the University laboratories. It contains specific requirements for how to handle... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project... framework for a new management system for wastes that are generated in University laboratories. This...

  18. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  19. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  20. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  1. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  2. 29 CFR 776.20 - “Goods.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) par. 63,098. 25 Darr v. Mutual Life Ins. Co., 169 F. 2d 262 (C.A. 2), certiorari denied 335 U.S. 871... of the Act if the employer, at the time the boat is being built, intends, hopes, or has reason to...

  3. 40 CFR 262.81 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... planned or takes place for the purpose of submitting the wastes to recovery operations therein. (g... and who proposes their transfrontier movement for the ultimate purpose of submitting them to recovery... activities leading to resource recovery, recycling, reclamation, direct re-use or alternative uses as listed...

  4. 45 CFR 160.201 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Preemption of State Law § 160.201 Applicability. The provisions of this subpart implement section 1178 of the Act, as added by section 262 of Public Law 104-191. ...

  5. 40 CFR 262.202 - This subpart is optional.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic...: Eligible academic entities have the option of complying with this subpart with respect to its laboratories... exempt small quantity generators. Eligible academic entities have the option of complying with this...

  6. 40 CFR 262.202 - This subpart is optional.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic...: Eligible academic entities have the option of complying with this subpart with respect to its laboratories... exempt small quantity generators. Eligible academic entities have the option of complying with this...

  7. 40 CFR 262.202 - This subpart is optional.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic...: Eligible academic entities have the option of complying with this subpart with respect to its laboratories... exempt small quantity generators. Eligible academic entities have the option of complying with this...

  8. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

    PubMed

    Gay, Sean C; Shah, Manish B; Talakad, Jyothi C; Maekawa, Keiko; Roberts, Arthur G; Wilderman, P Ross; Sun, Ling; Yang, Jane Y; Huelga, Stephanie C; Hong, Wen-Xu; Zhang, Qinghai; Stout, C David; Halpert, James R

    2010-04-01

    The structure of the K262R genetic variant of human cytochrome P450 2B6 in complex with the inhibitor 4-(4-chlorophenyl)imidazole (4-CPI) has been determined using X-ray crystallography to 2.0-A resolution. Production of diffraction quality crystals was enabled through a combination of protein engineering, chaperone coexpression, modifications to the purification protocol, and the use of unique facial amphiphiles during crystallization. The 2B6-4-CPI complex is virtually identical to the rabbit 2B4 structure bound to the same inhibitor with respect to the arrangement of secondary structural elements and the placement of active site residues. The structure supports prior P450 2B6 homology models based on other mammalian cytochromes P450 and is consistent with the limited site-directed mutagenesis studies on 2B6 and extensive studies on P450 2B4 and 2B1. Although the K262R genetic variant shows unaltered binding of 4-CPI, altered binding affinity, kinetics, and/or product profiles have been previously shown with several other ligands. On the basis of new P450 2B6 crystal structure and previous 2B4 structures, substitutions at residue 262 affect a hydrogen-bonding network connecting the G and H helices, where subtle differences could be transduced to the active site. Docking experiments indicate that the closed protein conformation allows smaller ligands such as ticlopidine to bind to the 2B6 active site in the expected orientation. However, it is unknown whether 2B6 undergoes structural reorganization to accommodate bulkier molecules, as previously inferred from multiple P450 2B4 crystal structures.

  9. Loss of heterozygosity at D8S262: an early genetic event of hepatocarcinogenesis.

    PubMed

    Zhu, Qiao; Gong, Li; Liu, Xiaoyan; Wang, Jun; Ren, Pin; Zhang, Wendong; Yao, Li; Han, Xiujuan; Zhu, Shaojun; Lan, Miao; Li, Yanhong; Zhang, Wei

    2015-06-16

    Hepatocellular carcinoma (HCC) is a multi-factor, multi-step, multi-gene and complicated process resulting from the accumulation of sequential genetic and epigenetic alterations. An important change among them is from precancerous lesions to HCC. However, only few studies have been reported about the sequential genetic changes during hepatocarcinogenesis. We observed firstly molecular karyotypes of 10 matched HCC using Affymetrix single-nucleotide polymorphism (SNP) 6.0 arrays, and found chromosomal fragments with high incidence (more than 70%) of loss of heterozygosity (LOH). Then, we selected 28 microsatellite markers at some gene spanning these chromosomal fragments, and examined the frequency of LOH of 128 matched HCC and 43 matched precancerous lesions-dysplastic nodules (DN) by a PCR-based analysis. Finally, we investigated the expression of proteins encoded by these genes in HCC, DN and the surrounding hepatic tissues. The result of Affymetrix SNP6.0 arrays demonstrated that more than 70% (7/10) cases had chromosomal fragment deletion on 4q13.3-35.1, 8p23.2-21.2, 16q11.2-24.3, and 17p13.3-12. Among 28 microsatellite markers selected, LOH frequencies at D8S262 for DN and HCC were found to be the highest, 51.2% and 72.7%, respectively. Immunohistochemically, the positive rate of its adjacent gene CSMD1 in HCC, DN, and the surrounding hepatic tissues were 27.3% (35/128), 75% (33/44), and 82% (105/128), respectively. LOH at D8S262 may be associated with an early genetic event of hepatocarcinogenesis, and a predictor for the monitor and prevention of HCC. The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1557074981159099 .

  10. 78 FR 53174 - Agency Forms Submitted for OMB Review, Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... income such as vacation pay or pay for time lost shall constitute sufficient evidence unless there is...: Form No. Annual responses Time (minutes) Burden (hours) ID-5i 1,050 15 262 ID-5R (SUP) 400 10 67 UI-48...

  11. 37 CFR 262.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... commercials or program segments, brief performances during news, talk and sports programming, brief background... distinguished from data that predominantly concern nonsubscribers or other services; and (5) Bad debts recovered... shall be permitted to deduct bad debts actually written off during a reporting period. [69 FR 5695, Feb...

  12. 37 CFR 262.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... commercials or program segments, brief performances during news, talk and sports programming, brief background... distinguished from data that predominantly concern nonsubscribers or other services; and (5) Bad debts recovered... shall be permitted to deduct bad debts actually written off during a reporting period. [69 FR 5695, Feb...

  13. 37 CFR 262.7 - Verification of royalty payments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Designated Agent have agreed as to proper verification methods. (b) Frequency of verification. A Copyright Owner or a Performer may conduct a single audit of the Designated Agent upon reasonable notice and... COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES RATES AND TERMS FOR CERTAIN ELIGIBLE...

  14. 28 CFR 34.2 - Exceptions to applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34.2 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Competition § 34.2 Exceptions to applicability. The following are assistance and procurement contract award situations that OJJDP considers to be outside the scope of the section 262(d)(1) competition requirement: (a...

  15. 20 CFR 1002.262 - When is the employer required to make the plan contribution that is attributable to the employee...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... allowed (but not required) to make up his or her missed contributions or elective deferrals. These makeup..., with the repayment period not to exceed five years. Makeup contributions or elective deferrals may only...

  16. 40 CFR 262.84 - Tracking document.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Transfrontier Shipments of Hazardous Waste for... (bulk shipments only) the generator must forward the tracking document with the manifest to the last... the U.S. which originate at the site of generation, the generator must forward the tracking document...

  17. 28 CFR 34.101 - Exceptions to applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 34.101 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.101 Exceptions to applicability. The assistance and procurement contract situations... outside the scope of the section 262(d) peer review requirement as set forth in this subpart. ...

  18. Anxiety and the School Experience.

    ERIC Educational Resources Information Center

    Docking, Russell A.; Thornton, Jennifer A.

    The Zuckerman Affect Adjective Check List (AACL) is used to measure trait anxiety and situation-specific trait anxiety relating to peer interaction, vocational aspiration, and the learning of English, mathematics, science and social studies. The subjects were 262 grade 10 students attending an Australian metropolitan high school. Additional…

  19. 40 CFR 262.89 - OECD Waste Lists.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements analogous to 40 CFR part 273, the export requirements in the spent lead-acid battery management... operations means activities leading to resource recovery, recycling, reclamation, direct re-use or... guarantees so required are intended to provide for alternate recycling, disposal or other means of sound...

  20. 30 CFR 1206.262 - Determination of transportation allowances.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Determination of transportation allowances... transportation allowances. (a) Arm's-length contracts. (1) For transportation costs incurred by a lessee pursuant to an arm's-length contract, the transportation allowance shall be the reasonable, actual costs...

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