40 CFR 265.223 - Containment system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Containment system. 265.223 Section 265.223 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES Surface Impoundments § 265.223 Containment system. All earthen dikes must have a protective cover...

40 CFR 265.231 - Air emission standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Air emission standards. 265.231 Section 265.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Surface Impoundments § 265.231 Air emission standards. The owner or operator shall...

40 CFR 265.231 - Air emission standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Air emission standards. 265.231 Section 265.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Surface Impoundments § 265.231 Air emission standards. The owner or operator shall...

40 CFR 265.231 - Air emission standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Air emission standards. 265.231 Section 265.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Surface Impoundments § 265.231 Air emission standards. The owner or operator shall...

40 CFR 265.231 - Air emission standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Air emission standards. 265.231 Section 265.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Surface Impoundments § 265.231 Air emission standards. The owner or operator shall...

40 CFR 265.223 - Containment system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Containment system. 265.223 Section 265.223 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES Surface Impoundments § 265.223 Containment system. All earthen dikes must have a protective cover...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

39 CFR 265.4 - Inquiries.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Inquiries. 265.4 Section 265.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.4 Inquiries. Inquiries regarding the availability of Postal Service records should be directed to the appropriate records...

39 CFR 265.4 - Inquiries.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Inquiries. 265.4 Section 265.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.4 Inquiries. Inquiries regarding the availability of Postal Service records should be directed to the appropriate records...

39 CFR 265.4 - Inquiries.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Inquiries. 265.4 Section 265.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.4 Inquiries. Inquiries regarding the availability of Postal Service records should be directed to the appropriate records...

39 CFR 265.4 - Inquiries.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Inquiries. 265.4 Section 265.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.4 Inquiries. Inquiries regarding the availability of Postal Service records should be directed to the appropriate records...

39 CFR 265.4 - Inquiries.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Inquiries. 265.4 Section 265.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.4 Inquiries. Inquiries regarding the availability of Postal Service records should be directed to the appropriate records...

40 CFR 265.202 - Air emission standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...

40 CFR 265.178 - Air emission standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Air emission standards. 265.178 Section 265.178 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Use and Management of Containers § 265.178 Air emission standards. The owner or...

40 CFR 265.178 - Air emission standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Air emission standards. 265.178 Section 265.178 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Use and Management of Containers § 265.178 Air emission standards. The owner or...

40 CFR 265.202 - Air emission standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...

40 CFR 265.202 - Air emission standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...

40 CFR 265.178 - Air emission standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Air emission standards. 265.178 Section 265.178 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Use and Management of Containers § 265.178 Air emission standards. The owner or...

40 CFR 265.178 - Air emission standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Air emission standards. 265.178 Section 265.178 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Use and Management of Containers § 265.178 Air emission standards. The owner or...

40 CFR 265.202 - Air emission standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...

45 CFR 156.265 - Enrollment process for qualified individuals.

Code of Federal Regulations, 2014 CFR

2014-10-01

....265 Section 156.265 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.265 Enrollment process...

45 CFR 156.265 - Enrollment process for qualified individuals.

Code of Federal Regulations, 2012 CFR

2012-10-01

....265 Section 156.265 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.265 Enrollment process...

45 CFR 156.265 - Enrollment process for qualified individuals.

Code of Federal Regulations, 2013 CFR

2013-10-01

....265 Section 156.265 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.265 Enrollment process...

40 CFR 265.18 - Location standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Location standards. 265.18 Section 265.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES General Facility Standards § 265.18 Location standards. The placement of any hazardous waste in a...

40 CFR 265.16 - Personnel training.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Personnel training. 265.16 Section 265... FACILITIES General Facility Standards § 265.16 Personnel training. (a)(1) Facility personnel must successfully complete a program of classroom instruction or on-the-job training that teaches them to perform...

39 CFR 265.10 - Annual report.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Annual report. 265.10 Section 265.10 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.10 Annual report. A report concerning the administration of the Freedom of Information Act and this part...

39 CFR 265.10 - Annual report.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Annual report. 265.10 Section 265.10 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.10 Annual report. A report concerning the administration of the Freedom of Information Act and this part...

39 CFR 265.3 - Responsibility.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Responsibility. 265.3 Section 265.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.3 Responsibility. (a) Custodian. Official records are in the custody of the postmaster or other head of a facility...

39 CFR 265.10 - Annual report.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Annual report. 265.10 Section 265.10 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.10 Annual report. A report concerning the administration of the Freedom of Information Act and this part...

39 CFR 265.10 - Annual report.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Annual report. 265.10 Section 265.10 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.10 Annual report. A report concerning the administration of the Freedom of Information Act and this part...

39 CFR 265.3 - Responsibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Responsibility. 265.3 Section 265.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.3 Responsibility. (a) Custodian. Official records are in the custody of the postmaster or other head of a facility...

39 CFR 265.10 - Annual report.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Annual report. 265.10 Section 265.10 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.10 Annual report. A report concerning the administration of the Freedom of Information Act and this part...

39 CFR 265.3 - Responsibility.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Responsibility. 265.3 Section 265.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.3 Responsibility. (a) Custodian. Official records are in the custody of the postmaster or other head of a facility...

39 CFR 265.3 - Responsibility.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Responsibility. 265.3 Section 265.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.3 Responsibility. (a) Custodian. Official records are in the custody of the postmaster or other head of a facility...

39 CFR 265.3 - Responsibility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Responsibility. 265.3 Section 265.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.3 Responsibility. (a) Custodian. Official records are in the custody of the postmaster or other head of a facility...

15 CFR 265.32 - Trespassing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

15 CFR 265.32 - Trespassing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

15 CFR 265.32 - Trespassing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

15 CFR 265.32 - Trespassing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

15 CFR 265.32 - Trespassing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

40 CFR 265.254 - Design and operating requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Design and operating requirements. 265.254 Section 265.254 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Waste Piles § 265.254 Design and operating requirements. The owner or operator of each...

40 CFR 265.14 - Security.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Security. 265.14 Section 265.14... Facility Standards § 265.14 Security. (a) The owner or operator must prevent the unknowing entry, and...) for discussion of security requirements at disposal facilities during the post-closure care period...

40 CFR 265.14 - Security.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Security. 265.14 Section 265.14... Facility Standards § 265.14 Security. (a) The owner or operator must prevent the unknowing entry, and...) for discussion of security requirements at disposal facilities during the post-closure care period...

40 CFR 265.14 - Security.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Security. 265.14 Section 265.14... Facility Standards § 265.14 Security. (a) The owner or operator must prevent the unknowing entry, and...) for discussion of security requirements at disposal facilities during the post-closure care period...

40 CFR 265.14 - Security.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Security. 265.14 Section 265.14... Facility Standards § 265.14 Security. (a) The owner or operator must prevent the unknowing entry, and...) for discussion of security requirements at disposal facilities during the post-closure care period...

40 CFR 265.148 - Incapacity of owners or operators, guarantors, or financial institutions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., guarantors, or financial institutions. 265.148 Section 265.148 Protection of Environment ENVIRONMENTAL... HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.148 Incapacity of owners or operators, guarantors, or financial institutions. (a) An owner or operator must notify the...

14 CFR 26.5 - Applicability table.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Applicability table. 26.5 Section 26.5... AIRWORTHINESS AND SAFETY IMPROVEMENTS FOR TRANSPORT CATEGORY AIRPLANES General § 26.5 Applicability table. Table... Subpart B EAPAS/FTS Subpart C widespread fatigue damage Subpart D fuel tankflammability Subpart E...

14 CFR 26.5 - Applicability table.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Applicability table. 26.5 Section 26.5... AIRWORTHINESS AND SAFETY IMPROVEMENTS FOR TRANSPORT CATEGORY AIRPLANES General § 26.5 Applicability table. Table... Subpart B EAPAS/FTS Subpart C widespread fatigue damage Subpart D fuel tankflammability Subpart E...

14 CFR 26.5 - Applicability table.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Applicability table. 26.5 Section 26.5... AIRWORTHINESS AND SAFETY IMPROVEMENTS FOR TRANSPORT CATEGORY AIRPLANES General § 26.5 Applicability table. Table... Subpart B EAPAS/FTS Subpart C widespread fatigue damage Subpart D fuel tankflammability Subpart E...

40 CFR 35.265 - Maximum federal share.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Maximum federal share. 35.265 Section 35.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE....265 Maximum federal share. The Regional Administrator may provide up to 60 percent of the approved...

In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265.

PubMed

Okamura, Nobuyuki; Mori, Masanori; Furumoto, Shozo; Yoshikawa, Takeo; Harada, Ryuichi; Ito, Satoshi; Fujikawa, Yosuke; Arai, Hiroyuki; Yanai, Kazuhiko; Kudo, Yukitsuka

2011-01-01

Noninvasive detection of amyloid-β (Aβ) deposits in the brain would be beneficial for an early and presymptomatic diagnosis of Alzheimer's disease (AD). We developed THK-265 as a candidate near-infrared fluorescence (NIRF) probe for the in vivo detection of amyloid deposits in the brain. The maximal emission wavelength of THK-265 was greater than 650nm and it showed high quantum yield and molar absorption coefficients. A fluorescence binding assay showed its high binding affinity to Aβ fibrils (Kd = 97 nM). THK-265 clearly stained amyloid plaques in AD neocortical brain sections and showed a moderate log p value (1.8). After intravenous administration of THK-265 in amyloid-β protein precursor (AβPP) transgenic mice, amyloid deposits in the brain were clearly labeled with THK-265. Furthermore, in vivo NIRF imaging demonstrated significantly higher fluorescence intensity in the brains of AβPP transgenic mice than in those of wild-type mice. As THK-265 showed profound hyperchromic effect upon binding to Aβ fibrils, good discrimination between AβPP transgenic and wild-type mice was demonstrated even early after THK-265 administration. Furthermore, the fluorescence intensity of THK-265 correlated with amyloid plaque burden in the brains of AβPP transgenic mice. These findings strongly support the usefulness of THK-265 as an NIRF imaging probe for the noninvasive measurement of brain amyloid load.

15 CFR 265.33 - Preservation of property.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Preservation of property. 265.33 Section 265.33 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.33 Preservation of...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

39 CFR 265.8 - Business information; procedures for predisclosure notification to submitters.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Business information; procedures for predisclosure notification to submitters. 265.8 Section 265.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.8 Business information; procedures for predisclosure notification to...

39 CFR 265.8 - Business information; procedures for predisclosure notification to submitters.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Business information; procedures for predisclosure notification to submitters. 265.8 Section 265.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.8 Business information; procedures for predisclosure notification to...

39 CFR 265.2 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Policy. 265.2 Section 265.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.2 Policy. (a) It is the policy of the Postal Service to make its official records available to the public to the maximum...

39 CFR 265.8 - Business information; procedures for predisclosure notification to submitters.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Business information; procedures for predisclosure notification to submitters. 265.8 Section 265.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.8 Business information; procedures for predisclosure notification to...

39 CFR 265.5 - Public reading rooms.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Public reading rooms. 265.5 Section 265.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.5 Public reading rooms. The Library of the Postal Service Headquarters, 475 L'Enfant Plaza SW, Washington, DC 20260...

39 CFR 265.11 - Compliance with subpoena duces tecum, court orders, and summonses.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., and summonses. 265.11 Section 265.11 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.11 Compliance with subpoena duces tecum, court orders, and summonses... release medical information, in response to proper requests and upon competent medical advice, in...

39 CFR 265.5 - Public reading rooms.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Public reading rooms. 265.5 Section 265.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.5 Public reading rooms. The Library of the Postal Service Headquarters, 475 L'Enfant Plaza SW, Washington, DC 20260...

39 CFR 265.5 - Public reading rooms.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Public reading rooms. 265.5 Section 265.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.5 Public reading rooms. The Library of the Postal Service Headquarters, 475 L'Enfant Plaza SW, Washington, DC 20260...

39 CFR 265.11 - Compliance with subpoena duces tecum, court orders, and summonses.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., and summonses. 265.11 Section 265.11 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.11 Compliance with subpoena duces tecum, court orders, and summonses... release medical information, in response to proper requests and upon competent medical advice, in...

39 CFR 265.11 - Compliance with subpoena duces tecum, court orders, and summonses.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., and summonses. 265.11 Section 265.11 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.11 Compliance with subpoena duces tecum, court orders, and summonses... release medical information, in response to proper requests and upon competent medical advice, in...

39 CFR 265.11 - Compliance with subpoena duces tecum, court orders, and summonses.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., and summonses. 265.11 Section 265.11 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.11 Compliance with subpoena duces tecum, court orders, and summonses... release medical information, in response to proper requests and upon competent medical advice, in...

39 CFR 265.2 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Policy. 265.2 Section 265.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.2 Policy. (a) It is the policy of the Postal Service to make its official records available to the public to the maximum...

39 CFR 265.8 - Business information; procedures for predisclosure notification to submitters.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Business information; procedures for predisclosure notification to submitters. 265.8 Section 265.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.8 Business information; procedures for predisclosure notification to...

39 CFR 265.8 - Business information; procedures for predisclosure notification to submitters.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Business information; procedures for predisclosure notification to submitters. 265.8 Section 265.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.8 Business information; procedures for predisclosure notification to...

39 CFR 265.2 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Policy. 265.2 Section 265.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.2 Policy. (a) It is the policy of the Postal Service to make its official records available to the public to the maximum...

39 CFR 265.2 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Policy. 265.2 Section 265.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.2 Policy. (a) It is the policy of the Postal Service to make its official records available to the public to the maximum...

39 CFR 265.5 - Public reading rooms.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Public reading rooms. 265.5 Section 265.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.5 Public reading rooms. The Library of the Postal Service Headquarters, 475 L'Enfant Plaza SW, Washington, DC 20260...

39 CFR 265.5 - Public reading rooms.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Public reading rooms. 265.5 Section 265.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.5 Public reading rooms. The Library of the Postal Service Headquarters, 475 L'Enfant Plaza SW, Washington, DC 20260...

39 CFR 265.11 - Compliance with subpoena duces tecum, court orders, and summonses.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., and summonses. 265.11 Section 265.11 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.11 Compliance with subpoena duces tecum, court orders, and summonses... release medical information, in response to proper requests and upon competent medical advice, in...

39 CFR 265.2 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Policy. 265.2 Section 265.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.2 Policy. (a) It is the policy of the Postal Service to make its official records available to the public to the maximum...

40 CFR 265.119 - Post-closure notices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 265.119 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... zoning authority, or the authority with jurisdiction over local land use, and to the Regional... required by §§ 265.116 and 265.119(a) have been filed with the local zoning authority or the authority with...

40 CFR 265.119 - Post-closure notices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 265.119 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... zoning authority, or the authority with jurisdiction over local land use, and to the Regional... required by §§ 265.116 and 265.119(a) have been filed with the local zoning authority or the authority with...

15 CFR 265.41 - Gambling.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Gambling. 265.41 Section 265.41..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.41 Gambling. No... gambling devices, the conduct of lotteries or pools, or in the selling or purchasing of numbers tickets, or...

40 CFR 265.1054 - Standards: Pressure relief devices in gas/vapor service.

Code of Federal Regulations, 2010 CFR

2010-07-01

... gas/vapor service. 265.1054 Section 265.1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... TREATMENT, STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Equipment Leaks § 265.1054 Standards: Pressure relief devices in gas/vapor service. (a) Except during pressure releases, each pressure relief...

15 CFR 265.41 - Gambling.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Gambling. 265.41 Section 265.41..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.41 Gambling. No person shall participate on the site in games for money or other property, or in the operation of...

15 CFR 265.41 - Gambling.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Gambling. 265.41 Section 265.41..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.41 Gambling. No... gambling devices, the conduct of lotteries or pools, or in the selling or purchasing of numbers tickets, or...

15 CFR 265.41 - Gambling.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Gambling. 265.41 Section 265.41..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.41 Gambling. No... gambling devices, the conduct of lotteries or pools, or in the selling or purchasing of numbers tickets, or...

15 CFR 265.41 - Gambling.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Gambling. 265.41 Section 265.41..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.41 Gambling. No... gambling devices, the conduct of lotteries or pools, or in the selling or purchasing of numbers tickets, or...

40 CFR 265.1088 - Standards: Closed-vent systems and control devices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Standards: Closed-vent systems and control devices. 265.1088 Section 265.1088 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Containers § 265.1088 Standards: Closed-vent systems and control devices. (a) This section applies to each...

15 CFR 265.42 - Photography for advertising or commercial purposes; advertising and soliciting.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Photography for advertising or commercial purposes; advertising and soliciting. 265.42 Section 265.42 Commerce and Foreign Trade Regulations... COLLINS, COLORADO Buildings and Grounds § 265.42 Photography for advertising or commercial purposes...

12 CFR 265.2 - Delegation of functions generally.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Delegation of functions generally. 265.2 Section 265.2 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING DELEGATION OF AUTHORITY § 265.2 Delegation of functions generally. (a) The...

40 CFR 265.1033 - Standards: Closed-vent systems and control devices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Standards: Closed-vent systems and control devices. 265.1033 Section 265.1033 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... total carbon working capacity -established as a requirement of § 265.1035(b)(4)(iii)(G), whichever is...

39 CFR Appendix A to Part 265 - Fees for Computer Searches

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Fees for Computer Searches A Appendix A to Part 265 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION Pt. 265, App. A Appendix A to Part 265—Fees for Computer Searches When requested information must be...

39 CFR Appendix A to Part 265 - Fees for Computer Searches

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Fees for Computer Searches A Appendix A to Part 265 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION Pt. 265, App. A Appendix A to Part 265—Fees for Computer Searches When requested information must be...

39 CFR 265.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Purpose and scope. 265.1 Section 265.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.1... section 552 of title 5, U.S.C., the “Freedom of Information Act,” insofar as it applies to the Postal...

39 CFR 265.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Purpose and scope. 265.1 Section 265.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.1... section 552 of title 5, U.S.C., the “Freedom of Information Act,” insofar as it applies to the Postal...

39 CFR Appendix A to Part 265 - Fees for Computer Searches

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Fees for Computer Searches A Appendix A to Part 265 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION Pt. 265, App. A Appendix A to Part 265—Fees for Computer Searches When requested information must be...

39 CFR 265.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Purpose and scope. 265.1 Section 265.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.1... section 552 of title 5, U.S.C., the “Freedom of Information Act,” insofar as it applies to the Postal...

39 CFR 265.7 - Procedure for inspection and copying of records.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... 265.7 Section 265.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.7 Procedure for inspection and copying of records. (a) Submission of requests... Service record shall be in writing and bear the caption “Freedom of Information Act Request” or otherwise...

39 CFR 265.7 - Procedure for inspection and copying of records.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... 265.7 Section 265.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.7 Procedure for inspection and copying of records. (a) Submission of requests... Service record shall be in writing and bear the caption “Freedom of Information Act Request” or otherwise...

39 CFR 265.7 - Procedure for inspection and copying of records.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... 265.7 Section 265.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.7 Procedure for inspection and copying of records. (a) Submission of requests... Service record shall be in writing and bear the caption “Freedom of Information Act Request” or otherwise...

39 CFR 265.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Purpose and scope. 265.1 Section 265.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.1... section 552 of title 5, U.S.C., the “Freedom of Information Act,” insofar as it applies to the Postal...

39 CFR 265.12 - Demands for testimony or records in certain legal proceedings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... proceedings. 265.12 Section 265.12 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.12 Demands for testimony or records in certain legal proceedings. (a) Scope...: (i) Records contained in the files of the Postal Service; (ii) Information relating to records...

39 CFR 265.12 - Demands for testimony or records in certain legal proceedings.

Code of Federal Regulations, 2012 CFR

2012-07-01

... proceedings. 265.12 Section 265.12 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.12 Demands for testimony or records in certain legal proceedings. (a) Scope...: (i) Records contained in the files of the Postal Service; (ii) Information relating to records...

39 CFR 265.12 - Demands for testimony or records in certain legal proceedings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... proceedings. 265.12 Section 265.12 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.12 Demands for testimony or records in certain legal proceedings. (a) Scope...: (i) Records contained in the files of the Postal Service; (ii) Information relating to records...

39 CFR 265.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Purpose and scope. 265.1 Section 265.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.1... section 552 of title 5, U.S.C., the “Freedom of Information Act,” insofar as it applies to the Postal...

39 CFR 265.12 - Demands for testimony or records in certain legal proceedings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... proceedings. 265.12 Section 265.12 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.12 Demands for testimony or records in certain legal proceedings. (a) Scope...: (i) Records contained in the files of the Postal Service; (ii) Information relating to records...

39 CFR Appendix A to Part 265 - Fees for Computer Searches

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Fees for Computer Searches A Appendix A to Part 265 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION Pt. 265, App. A Appendix A to Part 265—Fees for Computer Searches When requested information must be...

39 CFR 265.7 - Procedure for inspection and copying of records.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... 265.7 Section 265.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.7 Procedure for inspection and copying of records. (a) Submission of requests... Service record shall be in writing and bear the caption “Freedom of Information Act Request” or otherwise...

39 CFR 265.12 - Demands for testimony or records in certain legal proceedings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... proceedings. 265.12 Section 265.12 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.12 Demands for testimony or records in certain legal proceedings. (a) Scope...: (i) Records contained in the files of the Postal Service; (ii) Information relating to records...

39 CFR Appendix A to Part 265 - Fees for Computer Searches

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Fees for Computer Searches A Appendix A to Part 265 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION Pt. 265, App. A Appendix A to Part 265—Fees for Computer Searches When requested information must be...

40 CFR 265.255 - Action leakage rates.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Action leakage rates. 265.255 Section... FACILITIES Waste Piles § 265.255 Action leakage rates. (a) The owner or operator of waste pile units subject to § 265.254 must submit a proposed action leakage rate to the Regional Administrator when submitting...

40 CFR 265.302 - Action leakage rate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Action leakage rate. 265.302 Section... FACILITIES Landfills § 265.302 Action leakage rate. (a) The owner or operator of landfill units subject to § 265.301(a) must submit a proposed action leakage rate to the Regional Administrator when submitting...

40 CFR 265.222 - Action leakage rate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... to § 265.221(a). The action leakage rate is the maximum design flow rate that the leak detection... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Action leakage rate. 265.222 Section... FACILITIES Surface Impoundments § 265.222 Action leakage rate. (a) The owner or operator of surface...

27 CFR 26.265 - Determination of tax on articles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... articles. 26.265 Section 26.265 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Procedure at Port of Entry From the Virgin Islands § 26.265 Determination of tax on articles. Where articles...

27 CFR 26.265 - Determination of tax on articles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... articles. 26.265 Section 26.265 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Procedure at Port of Entry From the Virgin Islands § 26.265 Determination of tax on articles. Where articles...

27 CFR 26.265 - Determination of tax on articles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... articles. 26.265 Section 26.265 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Procedure at Port of Entry From the Virgin Islands § 26.265 Determination of tax on articles. Where articles...

26 CFR 1.265-2 - Interest relating to tax exempt income.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Interest relating to tax exempt income. 1.265-2 Section 1.265-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Not Deductible § 1.265-2 Interest relating to tax...

25 CFR 265.1 - Definition of roadless area.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Definition of roadless area. 265.1 Section 265.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS ON INDIAN RESERVATIONS § 265.1 Definition of roadless area. A roadless area has been defined...

25 CFR 265.1 - Definition of roadless area.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Definition of roadless area. 265.1 Section 265.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS ON INDIAN RESERVATIONS § 265.1 Definition of roadless area. A roadless area has been defined...

12 CFR 265.8 - Functions delegated to the Staff Director of the Division of International Finance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the Division of International Finance. 265.8 Section 265.8 Banks and Banking FEDERAL RESERVE SYSTEM... AUTHORITY § 265.8 Functions delegated to the Staff Director of the Division of International Finance. The Board's Staff Director of the Division of International Finance (or the Director's delegee) is...

12 CFR 265.8 - Functions delegated to the Staff Director of the Division of International Finance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the Division of International Finance. 265.8 Section 265.8 Banks and Banking FEDERAL RESERVE SYSTEM... AUTHORITY § 265.8 Functions delegated to the Staff Director of the Division of International Finance. The Board's Staff Director of the Division of International Finance (or the Director's delegee) is...

12 CFR 265.8 - Functions delegated to the Staff Director of the Division of International Finance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the Division of International Finance. 265.8 Section 265.8 Banks and Banking FEDERAL RESERVE SYSTEM... AUTHORITY § 265.8 Functions delegated to the Staff Director of the Division of International Finance. The Board's Staff Director of the Division of International Finance (or the Director's delegee) is...

15 CFR 265.51 - Penalties-other laws.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Penalties-other laws. 265.51 Section..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Penalties § 265.51 Penalties—other laws. Except with respect to the laws of the State of Maryland and the State of Colorado assimilated by § 265.5 or...

15 CFR 265.31 - Closing the site.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Closing the site. 265.31 Section 265..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.31 Closing the site... may be closed to the public in emergency situations and at such other times as may be necessary for...

40 CFR 265.316 - Disposal of small containers of hazardous waste in overpacked drums (lab packs).

Code of Federal Regulations, 2010 CFR

2010-07-01

... OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Landfills § 265.316 Disposal of small containers of hazardous waste in overpacked drums (lab packs). Small containers of hazardous waste... hazardous waste in overpacked drums (lab packs). 265.316 Section 265.316 Protection of Environment...

8 CFR 265.1 - Forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Forms. 265.1 Section 265.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS NOTICES OF ADDRESS § 265.1 Forms. Except... under section 262 of the Act shall report each change of address and new address within 10 days on Form...

45 CFR 265.6 - Must States file reports electronically?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Must States file reports electronically? 265.6 Section 265.6 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES DATA COLLECTION AND REPORTING REQUIREMENTS § 265.6...

40 CFR 265.228 - Closure and post-closure care.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Closure and post-closure care. 265.228... DISPOSAL FACILITIES Surface Impoundments § 265.228 Closure and post-closure care. (a) At closure, the owner... impoundment and provide post-closure care for a landfill under subpart G and § 265.310, including the...

40 CFR 265.228 - Closure and post-closure care.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Closure and post-closure care. 265.228... DISPOSAL FACILITIES Surface Impoundments § 265.228 Closure and post-closure care. (a) At closure, the owner... impoundment and provide post-closure care for a landfill under subpart G and § 265.310, including the...

12 CFR 26.5 - Small market share exemption.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Small market share exemption. 26.5 Section 26.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 26.5 Small market share exemption. (a) Exemption. A management interlock that is prohibited by § 26.3...

45 CFR 265.4 - When are quarterly reports due?

Code of Federal Regulations, 2010 CFR

2010-10-01

... COLLECTION AND REPORTING REQUIREMENTS § 265.4 When are quarterly reports due? (a) Each State must file the TANF Data Report and the TANF Financial Report (or, as applicable, the Territorial Financial Report... 45 Public Welfare 2 2010-10-01 2010-10-01 false When are quarterly reports due? 265.4 Section 265...

20 CFR 416.265 - Requirements for the special SSI eligibility status.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Requirements for the special SSI eligibility status. 416.265 Section 416.265 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A Disabling Impairment § 416.265 Requirement...

27 CFR 26.265 - Determination of tax on articles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... articles. 26.265 Section 26.265 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Procedure at Port of Entry From the Virgin Islands § 26.265 Determination of tax on articles. Where articles...

HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy

PubMed Central

Nelde, Annika; Walz, Juliane Sarah; Kowalewski, Daniel Johannes; Schuster, Heiko; Wolz, Olaf-Oliver; Peper, Janet Kerstin; Cardona Gloria, Yamel; Langerak, Anton W.; Muggen, Alice F.; Claus, Rainer; Bonzheim, Irina; Fend, Falko; Salih, Helmut Rainer; Kanz, Lothar; Rammensee, Hans-Georg; Stevanović, Stefan; Weber, Alexander N. R.

2017-01-01

ABSTRACT Genome sequencing has uncovered an array of recurring somatic mutations in different non-Hodgkin lymphoma (NHL) subtypes. If affecting protein-coding regions, such mutations may yield mutation-derived peptides that may be presented by HLA class I proteins and recognized by cytotoxic T cells. A recurring somatic and oncogenic driver mutation of the Toll-like receptor adaptor protein MYD88, Leu265Pro (L265P) was identified in up to 90% of different NHL subtype patients. We therefore screened the potential of MYD88L265P-derived peptides to elicit cytotoxic T cell responses as tumor-specific neoantigens. Based on in silico predictions, we identified potential MYD88L265P-containing HLA ligands for several HLA class I restrictions. A set of HLA class I MYD88L265P-derived ligands elicited specific cytotoxic T cell responses for HLA-B*07 and -B*15. These data highlight the potential of MYD88L265P mutation-specific peptide-based immunotherapy as a novel personalized treatment approach for patients with MYD88L265P+ NHLs that may complement pharmacological approaches targeting oncogenic MyD88 L265P signaling. PMID:28405493

45 CFR 265.5 - May States use sampling?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false May States use sampling? 265.5 Section 265.5... REQUIREMENTS § 265.5 May States use sampling? (a) Each State may report the disaggregated data in the TANF Data... the use of a scientifically acceptable sampling method that we have approved. States may use sampling...

45 CFR 265.5 - May States use sampling?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false May States use sampling? 265.5 Section 265.5... REQUIREMENTS § 265.5 May States use sampling? (a) Each State may report the disaggregated data in the TANF Data... the use of a scientifically acceptable sampling method that we have approved. States may use sampling...

41 CFR 301-10.265 - Will my travel on Government aircraft be reported?

Code of Federal Regulations, 2010 CFR

2010-07-01

... are a senior Federal official or a non-Federal traveler, any use you make of Government aircraft, i.e... Government aircraft be reported? 301-10.265 Section 301-10.265 Public Contracts and Property Management...-TRANSPORTATION EXPENSES Government Vehicle Travel on Government Aircraft § 301-10.265 Will my travel on...

41 CFR 301-10.265 - Will my travel on Government aircraft be reported?

Code of Federal Regulations, 2011 CFR

2011-07-01

... are a senior Federal official or a non-Federal traveler, any use you make of Government aircraft, i.e... Government aircraft be reported? 301-10.265 Section 301-10.265 Public Contracts and Property Management...-TRANSPORTATION EXPENSES Government Vehicle Travel on Government Aircraft § 301-10.265 Will my travel on...

40 CFR 265.276 - Food chain crops.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Food chain crops. 265.276 Section 265... FACILITIES Land Treatment § 265.276 Food chain crops. (a) An owner or operator of a hazardous waste land treatment facility on which food chain crops are being grown, or have been grown and will be grown in the...

40 CFR 265.276 - Food chain crops.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Food chain crops. 265.276 Section 265... FACILITIES Land Treatment § 265.276 Food chain crops. (a) An owner or operator of a hazardous waste land treatment facility on which food chain crops are being grown, or have been grown and will be grown in the...

40 CFR 265.276 - Food chain crops.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Food chain crops. 265.276 Section 265... FACILITIES Land Treatment § 265.276 Food chain crops. (a) An owner or operator of a hazardous waste land treatment facility on which food chain crops are being grown, or have been grown and will be grown in the...

40 CFR 265.276 - Food chain crops.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Food chain crops. 265.276 Section 265... FACILITIES Land Treatment § 265.276 Food chain crops. (a) An owner or operator of a hazardous waste land treatment facility on which food chain crops are being grown, or have been grown and will be grown in the...

40 CFR 265.276 - Food chain crops.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Food chain crops. 265.276 Section 265... FACILITIES Land Treatment § 265.276 Food chain crops. (a) An owner or operator of a hazardous waste land treatment facility on which food chain crops are being grown, or have been grown and will be grown in the...

26 CFR 1.265-2 - Interest relating to tax exempt income.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Interest relating to tax exempt income. 1.265-2 Section 1.265-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Items Not Deductible § 1.265-2 Interest relating to tax exempt income. (a...

46 CFR 148.265 - Fish meal or fish scrap.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Fish meal or fish scrap. 148.265 Section 148.265... MATERIALS THAT REQUIRE SPECIAL HANDLING Special Requirements for Certain Materials § 148.265 Fish meal or fish scrap. (a) This part does not apply to fish meal or fish scrap that contains less than 5 percent...

46 CFR 148.265 - Fish meal or fish scrap.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Fish meal or fish scrap. 148.265 Section 148.265... MATERIALS THAT REQUIRE SPECIAL HANDLING Special Requirements for Certain Materials § 148.265 Fish meal or fish scrap. (a) This part does not apply to fish meal or fish scrap that contains less than 5 percent...

46 CFR 148.265 - Fish meal or fish scrap.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Fish meal or fish scrap. 148.265 Section 148.265... MATERIALS THAT REQUIRE SPECIAL HANDLING Special Requirements for Certain Materials § 148.265 Fish meal or fish scrap. (a) This part does not apply to fish meal or fish scrap that contains less than 5 percent...

40 CFR 265.94 - Recordkeeping and reporting.

Code of Federal Regulations, 2011 CFR

2011-07-01

... required in § 265.92(e), and the evaluations required in § 265.93(b) throughout the active life of the... found in the upgradient wells, in accordance with § 265.93(c)(1). During the active life of the facility, this information must be submitted no later than March 1 following each calendar year. (iii) No later...

45 CFR 265.10 - When is the annual report due?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true When is the annual report due? 265.10 Section 265.10 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES DATA COLLECTION AND REPORTING REQUIREMENTS § 265.10 When is...

45 CFR 265.4 - When are quarterly reports due?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true When are quarterly reports due? 265.4 Section 265.4 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES DATA COLLECTION AND REPORTING REQUIREMENTS § 265.4 When are...

21 CFR 1271.265 - Receipt, predistribution shipment, and distribution of an HCT/P.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and constructed to protect the HCT/P from contamination. For each type of HCT/P, you must establish... distribution of an HCT/P. 1271.265 Section 1271.265 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Practice § 1271.265 Receipt, predistribution shipment, and distribution of an HCT/P. (a) Receipt. You must...

25 CFR 26.5 - Who may be eligible for Job Placement and Training?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Who may be eligible for Job Placement and Training? 26.5 Section 26.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.5 Who may be eligible for Job Placement and Training? You may...

25 CFR 26.5 - Who may be eligible for Job Placement and Training?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Who may be eligible for Job Placement and Training? 26.5 Section 26.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.5 Who may be eligible for Job Placement and Training? You may...

25 CFR 26.5 - Who may be eligible for Job Placement and Training?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Who may be eligible for Job Placement and Training? 26.5 Section 26.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.5 Who may be eligible for Job Placement and Training? You may...

25 CFR 26.5 - Who may be eligible for Job Placement and Training?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Who may be eligible for Job Placement and Training? 26.5 Section 26.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.5 Who may be eligible for Job Placement and Training? You may...

25 CFR 26.5 - Who may be eligible for Job Placement and Training?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Who may be eligible for Job Placement and Training? 26.5 Section 26.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.5 Who may be eligible for Job Placement and Training? You may...

12 CFR 265.8 - Functions delegated to the Staff Director of the Division of International Finance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Functions delegated to the Staff Director of the Division of International Finance. 265.8 Section 265.8 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING DELEGATION OF AUTHORITY § 265.8 Functions delegated to the Staff Director...

Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P-Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases.

PubMed

Dubois, Sydney; Viailly, Pierre-Julien; Bohers, Elodie; Bertrand, Philippe; Ruminy, Philippe; Marchand, Vinciane; Maingonnat, Catherine; Mareschal, Sylvain; Picquenot, Jean-Michel; Penther, Dominique; Jais, Jean-Philippe; Tesson, Bruno; Peyrouze, Pauline; Figeac, Martin; Desmots, Fabienne; Fest, Thierry; Haioun, Corinne; Lamy, Thierry; Copie-Bergman, Christiane; Fabiani, Bettina; Delarue, Richard; Peyrade, Frédéric; André, Marc; Ketterer, Nicolas; Leroy, Karen; Salles, Gilles; Molina, Thierry J; Tilly, Hervé; Jardin, Fabrice

2017-05-01

Purpose: MYD88 mutations, notably the recurrent gain-of-function L265P variant, are a distinguishing feature of activated B-cell like (ABC) diffuse large B-cell lymphoma (DLBCL), leading to constitutive NFκB pathway activation. The aim of this study was to examine the distinct genomic profiles of MYD88 -mutant DLBCL, notably according to the presence of the L265P or other non-L265P MYD88 variants. Experimental Design: A cohort of 361 DLBCL cases (94 MYD88 mutant and 267 MYD88 wild-type) was submitted to next-generation sequencing (NGS) focusing on 34 genes to analyze associated mutations and copy number variations, as well as gene expression profiling, and clinical and prognostic analyses. Results: Importantly, we highlighted different genomic profiles for MYD88 L265P and MYD88 non-L265P-mutant DLBCL, shedding light on their divergent backgrounds. Clustering analysis also segregated subgroups according to associated genetic alterations among patients with the same MYD88 mutation. We showed that associated CD79B and MYD88 L265P mutations act synergistically to increase NFκB pathway activation, although the majority of MYD88 L265P-mutant cases harbors downstream NFκB alterations, which can predict BTK inhibitor resistance. Finally, although the MYD88 L265P variant was not an independent prognostic factor in ABC DLBCL, associated CD79B mutations significantly improved the survival of MYD88 L265P-mutant ABC DLBCL in our cohort. Conclusions: This study highlights the relative heterogeneity of MYD88 -mutant DLBCL, adding to the field's knowledge of the theranostic importance of MYD88 mutations, but also of associated alterations, emphasizing the usefulness of genomic profiling to best stratify patients for targeted therapy. Clin Cancer Res; 23(9); 2232-44. ©2016 AACR . ©2016 American Association for Cancer Research.

Seasonal and interannual variability in along-slope oceanic properties off the US West Coast: Inferences from a high-resolution regional model

NASA Astrophysics Data System (ADS)

Kurapov, A. L.; Pelland, N. A.; Rudnick, D. L.

2017-07-01

A 6 year, 2009-2014 simulation using a 2 km horizontal resolution ocean circulation model of the Northeast Pacific coast is analyzed with focus on seasonal and interannual variability in along-slope subsurface oceanic properties. Specifically, the fields are sampled on the isopycnal surface σ=26.5 kg m-3 that is found between depths of 150 and 300 m below the ocean surface over the continental slope. The fields analyzed include the depth z26.5, temperature T26.5, along-slope current v26.5, and the average potential vorticity PV between σ = 26.5 and 26.25 kg m-3. Each field is averaged in the cross-shore direction over the continental slope and presented as a function of the alongshore coordinate and time. The seasonal cycle in z26.5 shows a coherent upwelling-downwelling pattern from Mexico to Canada propagating to the north with a speed of 0.5 m s-1. The anomalously deep (-20 m) z26.5 displacement in spring-summer 2014 is forced by the southern boundary condition at 24°N as a manifestation of an emerging strong El Niño. The seasonal cycle in T26.5 is most pronounced between 36°N and 53°N indicating that subarctic waters are replaced by warmer Californian waters in summer with the speed close 0.15 m s-1, which is consistent with earlier estimates of the undercurrent speed and also present v26.5 analyses. The seasonal patterns and anomalies in z26.5 and T26.5 find confirmation in available long-term glider and shipborne observations. The PV seasonality over the slope is qualitatively different to the south and north of the southern edge of Heceta Bank (43.9°N).

A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia.

PubMed

Yang, Guang; Zhou, Yangsheng; Liu, Xia; Xu, Lian; Cao, Yang; Manning, Robert J; Patterson, Christopher J; Buhrlage, Sara J; Gray, Nathanael; Tai, Yu-Tzu; Anderson, Kenneth C; Hunter, Zachary R; Treon, Steven P

2013-08-15

Myeloid differentiation factor 88 (MYD88) L265P somatic mutation is highly prevalent in Waldenström macroglobulinemia (WM) and supports malignant growth through nuclear factor κB (NF-κB). The signaling cascade(s) by which MYD88 L265P promotes NF-κB activation in WM remain unclear. By lentiviral knockdown or use of a MYD88 inhibitor, decreased phosphorylation of the NF-κB gatekeeper IκBα and survival occurred in MYD88 L265P-expressing WM cells. Conversely, WM cells engineered to overexpress MYD88 L265P showed enhanced survival. Coimmunoprecipitation studies identified Bruton tyrosine kinase (BTK) complexed to MYD88 in L265P-expressing WM cells, with preferential binding of MYD88 to phosphorylated BTK (pBTK). Increased pBTK was also observed in WM cells transduced to overexpress L265P vs wild-type MYD88. Importantly, MYD88 binding to BTK was abrogated following treatment of MYD88 L265P-expressing cells with a BTK kinase inhibitor. Inhibition of BTK or interleukin-1 receptor-associated kinase 1 and 4 (IRAK-1 and -4) kinase activity induced apoptosis of WM cells, and their combination resulted in more robust inhibition of NF-κB signaling and synergistic WM cell killing. The results establish BTK as a downstream target of MYD88 L265P signaling, and provide a framework for the study of BTK inhibitors alone, and in combination with IRAK inhibitors for the treatment of WM.

15 CFR 265.18 - Prohibited servicing of vehicles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Prohibited servicing of vehicles. 265... § 265.18 Prohibited servicing of vehicles. No person shall make nonemergency repairs on privately owned vehicles on the site. ...

15 CFR 265.18 - Prohibited servicing of vehicles.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Prohibited servicing of vehicles. 265... § 265.18 Prohibited servicing of vehicles. No person shall make nonemergency repairs on privately owned vehicles on the site. ...

7 CFR 4279.265 - Guarantee application evaluation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Guarantee application evaluation. 4279.265 Section 4279.265 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Biorefinery...

7 CFR 4279.265 - Guarantee application evaluation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Guarantee application evaluation. 4279.265 Section 4279.265 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Biorefinery...

7 CFR 4279.265 - Guarantee application evaluation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Guarantee application evaluation. 4279.265 Section 4279.265 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Biorefinery...

Video Compression Study: h.265 vs h.264

NASA Technical Reports Server (NTRS)

Pryor, Jonathan

2016-01-01

H.265 video compression (also known as High Efficiency Video Encoding (HEVC)) promises to provide double the video quality at half the bandwidth, or the same quality at half the bandwidth of h.264 video compression [1]. This study uses a Tektronix PQA500 to determine the video quality gains by using h.265 encoding. This study also compares two video encoders to see how different implementations of h.264 and h.265 impact video quality at various bandwidths.

Design and activity of novel lactoferrampin analogues against O157:H7 enterohemorrhagic Escherichia coli.

PubMed

Cruz, Jenniffer; Ortiz, Claudia; Guzmán, Fanny; Cárdenas, Constanza; Fernandez-Lafuente, Roberto; Torres, Rodrigo

2014-04-01

Lactoferrampin 265-284 (LFampin 265-284) is a peptide consisting of residues 265-284 of N1-domain of bovine Lactoferrin (LF). This peptide has several cationic groups in the C-terminal lobe, exhibiting an antibacterial activity against a wide range of microorganisms. However, LFampin 265-284 exhibits low antimicrobial activity against the O157:H7 enterohaemorrhagic Escherichia coli (EHEC O157:H7) when compared with Lactoferrin chimera and Lactoferricin. Here, we have designed three analogues of LFampin 265-284 based on the distribution of cationic groups, hydrophobicity, size, and sequence. Analogues were synthesized by solid phase chemistry using Fmoc methodology obtaining peptides with 95% purity. All peptides maintain the ability to adopt helical conformations (checked by circular dichroism spectra and molecular simulations). Some of these analogues exhibited a significant increase in antimicrobial activity by counting colony forming units against EHEC O157:H7 compared to native LFampin 265-284, with MIC of 10 and 40 µM for 264G-D265K and 264G-D265K/S272R, respectively. The incorporation of a GKLI sequence in the N-terminal lobe increased dramatically its antibacterial activity, an effect which has been attributed to the addition of cationic groups in the N-terminal side that may stabilize the helical conformation of the new designed peptides. Copyright © 2013 Wiley Periodicals, Inc.

41 CFR 102-118.265 - What is a prepayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... audit? 102-118.265 Section 102-118.265 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements for Prepayment Audits...

40 CFR 265.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the wastes, application of advanced technology, or alternative disposal, treatment, or re-use.... 265.118 Section 265.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT...

40 CFR 265.1200 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1200 Applicability. The requirements of this subpart apply to owners or operators who store munitions and explosive hazardous wastes, except as § 265.1 provides otherwise. (NOTE: Depending on explosive hazards, hazardous waste munitions and...

40 CFR 265.1200 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1200 Applicability. The requirements of this subpart apply to owners or operators who store munitions and explosive hazardous wastes, except as § 265.1 provides otherwise. (NOTE: Depending on explosive hazards, hazardous waste munitions and...

40 CFR 265.1200 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1200 Applicability. The requirements of this subpart apply to owners or operators who store munitions and explosive hazardous wastes, except as § 265.1 provides otherwise. (NOTE: Depending on explosive hazards, hazardous waste munitions and...

40 CFR 265.1200 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1200 Applicability. The requirements of this subpart apply to owners or operators who store munitions and explosive hazardous wastes, except as § 265.1 provides otherwise. (NOTE: Depending on explosive hazards, hazardous waste munitions and...

40 CFR 265.1200 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1200 Applicability. The requirements of this subpart apply to owners or operators who store munitions and explosive hazardous wastes, except as § 265.1 provides otherwise. (NOTE: Depending on explosive hazards, hazardous waste munitions and...

40 CFR 265.441 - Assessment of existing drip pad integrity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... detection systems of § 265.443(b). No later than the effective date of this rule, the owner or operator must... standards for liners and leak detection systems, specified in § 265.443(b). (b) The owner or operator must...

15 CFR 265.16 - Parking.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Parking. 265.16 Section 265.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE REGULATIONS GOVERNING TRAFFIC AND CONDUCT REGULATIONS...

15 CFR 265.16 - Parking.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Parking. 265.16 Section 265.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE REGULATIONS GOVERNING TRAFFIC AND CONDUCT REGULATIONS...

15 CFR 265.16 - Parking.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Parking. 265.16 Section 265.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE REGULATIONS GOVERNING TRAFFIC AND CONDUCT REGULATIONS...

40 CFR 265.77 - Additional reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

....77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL... submitting the biennial report and unmanifested waste reports described in §§ 265.75 and 265.76, the owner or...

40 CFR 265.272 - General operating requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false General operating requirements. 265.272 Section 265.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... nonhazardous by degradation, transformation, or immobilization processes occurring in or on the soil. (b) The...

40 CFR 265.31 - Maintenance and operation of facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., soil, or surface water which could threaten human health or the -environment. ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Maintenance and operation of facility. 265.31 Section 265.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

40 CFR 265.1201 - Design and operating standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Design and operating standards. 265.1201 Section 265.1201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...) Provide monitoring and inspection procedures that assure the controls and containment systems are working...

40 CFR 265.76 - Unmanifested waste report.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Unmanifested waste report. 265.76 Section 265.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.13 - General waste analysis.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false General waste analysis. 265.13 Section 265.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL...

40 CFR 265.76 - Unmanifested waste report.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Unmanifested waste report. 265.76 Section 265.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.76 - Unmanifested waste report.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Unmanifested waste report. 265.76 Section 265.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.13 - General waste analysis.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false General waste analysis. 265.13 Section 265.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL...

40 CFR 265.76 - Unmanifested waste report.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Unmanifested waste report. 265.76 Section 265.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.13 - General waste analysis.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false General waste analysis. 265.13 Section 265.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL...

40 CFR 265.76 - Unmanifested waste report.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Unmanifested waste report. 265.76 Section 265.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.13 - General waste analysis.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false General waste analysis. 265.13 Section 265.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL...

40 CFR 265.250 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Piles § 265.250 Applicability. The regulations in this subpart apply to owners and operators of facilities that treat or store hazardous waste in piles, except as § 265.1 provides otherwise. Alternatively, a pile of hazardous waste may be managed as a landfill under subpart N. ...

40 CFR 265.198 - Special requirements for ignitable or reactive wastes.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) The resulting waste, mixture, or dissolved material no longer meets the definition of ignitable or... reactive wastes. 265.198 Section 265.198 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE...

40 CFR 265.140 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this subpart applying to a regulated unit with alternative requirements for financial assurance set out... STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Financial... Administrator: (1) Prescribes alternative requirements for the regulated unit under § 265.90(f) and/or 265.110(d...

40 CFR 265.174 - Inspections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management of Containers § 265.174 Inspections. At least weekly, the owner or operator must inspect areas where containers are stored, except for Performance Track member facilities, that must conduct..., the Performance Track member facility must follow the procedures described in § 265.15(b)(5) of this...

40 CFR 265.174 - Inspections.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Management of Containers § 265.174 Inspections. At least weekly, the owner or operator must inspect areas where containers are stored, except for Performance Track member facilities, that must conduct..., the Performance Track member facility must follow the procedures described in § 265.15(b)(5) of this...

40 CFR 265.174 - Inspections.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Management of Containers § 265.174 Inspections. At least weekly, the owner or operator must inspect areas where containers are stored, except for Performance Track member facilities, that must conduct..., the Performance Track member facility must follow the procedures described in § 265.15(b)(5) of this...

40 CFR 265.174 - Inspections.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Management of Containers § 265.174 Inspections. At least weekly, the owner or operator must inspect areas where containers are stored, except for Performance Track member facilities, that must conduct..., the Performance Track member facility must follow the procedures described in § 265.15(b)(5) of this...

40 CFR 265.174 - Inspections.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Management of Containers § 265.174 Inspections. At least weekly, the owner or operator must inspect areas where containers are stored, except for Performance Track member facilities, that must conduct..., the Performance Track member facility must follow the procedures described in § 265.15(b)(5) of this...

40 CFR 265.254 - Design and operating requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

....254 Section 265.254 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 265.254 Design and operating requirements. The owner or operator of each...

40 CFR 1065.265 - Nonmethane cutter.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Nonmethane cutter. 1065.265 Section 1065.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS... sample with purified air or oxygen (O2) upstream of the nonmethane cutter to optimize its performance...

40 CFR 1065.265 - Nonmethane cutter.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Nonmethane cutter. 1065.265 Section 1065.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS... sample with purified air or oxygen (O2) upstream of the nonmethane cutter to optimize its performance...

40 CFR 1065.265 - Nonmethane cutter.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Nonmethane cutter. 1065.265 Section 1065.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS... with purified air or oxygen (O2) upstream of the nonmethane cutter to optimize its performance. You...

40 CFR 1065.265 - Nonmethane cutter.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Nonmethane cutter. 1065.265 Section 1065.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS... with purified air or oxygen (O2) upstream of the nonmethane cutter to optimize its performance. You...

40 CFR 1065.265 - Nonmethane cutter.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Nonmethane cutter. 1065.265 Section 1065.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS... sample with purified air or oxygen (O2) upstream of the nonmethane cutter to optimize its performance...

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

PubMed Central

Phillips, Margaret A.; Lotharius, Julie; Marsh, Kennan; White, John; Dayan, Anthony; White, Karen L.; Njoroge, Jacqueline W.; El Mazouni, Farah; Lao, Yanbin; Kokkonda, Sreekanth; Tomchick, Diana R.; Deng, Xiaoyi; Laird, Trevor; Bhatia, Sangeeta N.; March, Sandra; Ng, Caroline L.; Fidock, David A.; Wittlin, Sergio; Lafuente-Monasterio, Maria; Benito, Francisco Javier Gamo; Alonso, Laura Maria Sanz; Martinez, Maria Santos; Jimenez-Diaz, Maria Belen; Bazaga, Santiago Ferrer; Angulo-Barturen, Iñigo; Haselden, John N.; Louttit, James; Cui, Yi; Sridhar, Arun; Zeeman, Anna-Marie; Kocken, Clemens; Sauerwein, Robert; Dechering, Koen; Avery, Vicky M.; Duffy, Sandra; Delves, Michael; Sinden, Robert; Ruecker, Andrea; Wickham, Kristina S.; Rochford, Rosemary; Gahagen, Janet; Iyer, Lalitha; Riccio, Ed; Mirsalis, Jon; Bathhurst, Ian; Rueckle, Thomas; Ding, Xavier; Campo, Brice; Leroy, Didier; Rogers, M. John; Rathod, Pradipsinh K.; Burrows, Jeremy N.; Charman, Susan A.

2015-01-01

Malaria is one of the most significant causes of childhood mortality but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating malaria requires development of new, easy to administer drug combinations with broad ranging activity against all manifestations of the disease. DSM265, a triazolopyrimidine-based inhibitor of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical development for treatment of malaria. We describe studies profiling the biological activity, pharmacological and pharmacokinetic properties, and safety of DSM265, which supported its advancement to human trials. DSM265 is highly selective towards DHODH of the malaria parasite Plasmodium, efficacious against both blood and liver stages of P. falciparum, and active against drug-resistant parasite isolates. Favorable pharmacokinetic properties of DSM265 are predicted to provide therapeutic concentrations for more than 8 days after a single oral dose in the range of 200–400 mg. DSM265 was well tolerated in repeat dose and cardiovascular safety studies in mice and dogs, was not mutagenic, and was inactive against panels of human enzymes/receptors. The excellent safety profile, blood and liver-stage activity, and predicted long human half-life position DSM265 as a new potential drug combination partner for either single-dose treatment or once weekly chemoprevention. DSM265 has advantages over current treatment options that are dosed daily or are inactive on the parasite liver-stage PMID:26180101

40 CFR 265.309 - Surveying and recordkeeping.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Surveying and recordkeeping. 265.309... DISPOSAL FACILITIES Landfills § 265.309 Surveying and recordkeeping. The owner or operator of a landfill... location and dimensions, including depth, of each cell with respect to permanently surveyed benchmarks; and...

40 CFR 265.309 - Surveying and recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Surveying and recordkeeping. 265.309... DISPOSAL FACILITIES Landfills § 265.309 Surveying and recordkeeping. The owner or operator of a landfill... location and dimensions, including depth, of each cell with respect to permanently surveyed benchmarks; and...

40 CFR 265.309 - Surveying and recordkeeping.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Surveying and recordkeeping. 265.309... DISPOSAL FACILITIES Landfills § 265.309 Surveying and recordkeeping. The owner or operator of a landfill... location and dimensions, including depth, of each cell with respect to permanently surveyed benchmarks; and...

40 CFR 265.309 - Surveying and recordkeeping.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Surveying and recordkeeping. 265.309... DISPOSAL FACILITIES Landfills § 265.309 Surveying and recordkeeping. The owner or operator of a landfill... location and dimensions, including depth, of each cell with respect to permanently surveyed benchmarks; and...

5 CFR 532.265 - Special wage schedules for apprentices and shop trainees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... and shop trainees. 532.265 Section 532.265 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... schedules for apprentices and shop trainees. (a) Agencies may establish special wage schedules for apprentices and shop trainees who are included in: (1) Formal apprenticeship programs involving training for...

5 CFR 532.265 - Special wage schedules for apprentices and shop trainees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... and shop trainees. 532.265 Section 532.265 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... schedules for apprentices and shop trainees. (a) Agencies may establish special wage schedules for apprentices and shop trainees who are included in: (1) Formal apprenticeship programs involving training for...

5 CFR 532.265 - Special wage schedules for apprentices and shop trainees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... and shop trainees. 532.265 Section 532.265 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... schedules for apprentices and shop trainees. (a) Agencies may establish special wage schedules for apprentices and shop trainees who are included in: (1) Formal apprenticeship programs involving training for...

5 CFR 532.265 - Special wage schedules for apprentices and shop trainees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... and shop trainees. 532.265 Section 532.265 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... schedules for apprentices and shop trainees. (a) Agencies may establish special wage schedules for apprentices and shop trainees who are included in: (1) Formal apprenticeship programs involving training for...

40 CFR 265.382 - Open burning; waste explosives.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Open burning; waste explosives. 265... DISPOSAL FACILITIES Thermal Treatment § 265.382 Open burning; waste explosives. Open burning of hazardous waste is prohibited except for the open burning and detonation of waste explosives. Waste explosives...

40 CFR 265.382 - Open burning; waste explosives.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Open burning; waste explosives. 265... DISPOSAL FACILITIES Thermal Treatment § 265.382 Open burning; waste explosives. Open burning of hazardous waste is prohibited except for the open burning and detonation of waste explosives. Waste explosives...

40 CFR 265.382 - Open burning; waste explosives.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Open burning; waste explosives. 265... DISPOSAL FACILITIES Thermal Treatment § 265.382 Open burning; waste explosives. Open burning of hazardous waste is prohibited except for the open burning and detonation of waste explosives. Waste explosives...

40 CFR 265.382 - Open burning; waste explosives.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Open burning; waste explosives. 265... DISPOSAL FACILITIES Thermal Treatment § 265.382 Open burning; waste explosives. Open burning of hazardous waste is prohibited except for the open burning and detonation of waste explosives. Waste explosives...

40 CFR 265.382 - Open burning; waste explosives.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Open burning; waste explosives. 265... DISPOSAL FACILITIES Thermal Treatment § 265.382 Open burning; waste explosives. Open burning of hazardous waste is prohibited except for the open burning and detonation of waste explosives. Waste explosives...

40 CFR 265.35 - Required aisle space.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Required aisle space. 265.35 Section... FACILITIES Preparedness and Prevention § 265.35 Required aisle space. The owner or operator must maintain aisle space to allow the unobstructed movement of personnel, fire protection equipment, spill control...

40 CFR 265.35 - Required aisle space.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Required aisle space. 265.35 Section... FACILITIES Preparedness and Prevention § 265.35 Required aisle space. The owner or operator must maintain aisle space to allow the unobstructed movement of personnel, fire protection equipment, spill control...

40 CFR 265.35 - Required aisle space.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Required aisle space. 265.35 Section... FACILITIES Preparedness and Prevention § 265.35 Required aisle space. The owner or operator must maintain aisle space to allow the unobstructed movement of personnel, fire protection equipment, spill control...

40 CFR 265.35 - Required aisle space.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Required aisle space. 265.35 Section... FACILITIES Preparedness and Prevention § 265.35 Required aisle space. The owner or operator must maintain aisle space to allow the unobstructed movement of personnel, fire protection equipment, spill control...

40 CFR 265.35 - Required aisle space.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Required aisle space. 265.35 Section... FACILITIES Preparedness and Prevention § 265.35 Required aisle space. The owner or operator must maintain aisle space to allow the unobstructed movement of personnel, fire protection equipment, spill control...

15 CFR 265.12 - Speeding or reckless driving.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Speeding or reckless driving. 265.12 Section 265.12 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE REGULATIONS GOVERNING TRAFFIC AND CONDUCT...

40 CFR 265.54 - Amendment of contingency plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Amendment of contingency plan. 265.54... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.54 Amendment of contingency plan. The contingency plan must be reviewed, and immediately amended, if necessary, whenever: (a) Applicable regulations...

40 CFR 265.54 - Amendment of contingency plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Amendment of contingency plan. 265.54... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.54 Amendment of contingency plan. The contingency plan must be reviewed, and immediately amended, if necessary, whenever: (a) Applicable regulations...

5 CFR 532.265 - Special wage schedules for apprentices and shop trainees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... and shop trainees. 532.265 Section 532.265 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... schedules for apprentices and shop trainees. (a) Agencies may establish special wage schedules for apprentices and shop trainees who are included in: (1) Formal apprenticeship programs involving training for...

40 CFR 265.1087 - Standards: Containers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... integral part of the container structural design (e.g., a “portable tank” or bulk cargo container equipped... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Standards: Containers. 265.1087... DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1087...

40 CFR 265.1087 - Standards: Containers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... integral part of the container structural design (e.g., a “portable tank” or bulk cargo container equipped... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Standards: Containers. 265.1087... DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1087...

40 CFR 265.1087 - Standards: Containers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... integral part of the container structural design (e.g., a “portable tank” or bulk cargo container equipped... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Standards: Containers. 265.1087... DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1087...

40 CFR 265.1087 - Standards: Containers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... integral part of the container structural design (e.g., a “portable tank” or bulk cargo container equipped... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Standards: Containers. 265.1087... DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1087...

40 CFR 265.1090 - Recordkeeping requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1090... containers using Container Level 3 air emission controls in accordance with the requirements of § 265.1087 of... section when the tank, surface impoundment, or container is or would be operating at capacity or the...

40 CFR 265.1090 - Recordkeeping requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1090... containers using Container Level 3 air emission controls in accordance with the requirements of § 265.1087 of... section when the tank, surface impoundment, or container is or would be operating at capacity or the...

40 CFR 265.11 - Identification number.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

40 CFR 265.11 - Identification number.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

40 CFR 265.11 - Identification number.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

40 CFR 265.11 - Identification number.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

40 CFR 265.11 - Identification number.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

18 CFR 284.265 - Cost recovery by interstate pipeline.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 1978 AND RELATED AUTHORITIES Emergency Natural Gas Sale, Transportation, and Exchange Transactions... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Cost recovery by interstate pipeline. 284.265 Section 284.265 Conservation of Power and Water Resources FEDERAL ENERGY...

40 CFR 265.54 - Amendment of contingency plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Amendment of contingency plan. 265.54... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.54 Amendment of contingency plan. The contingency plan must be reviewed, and immediately amended, if necessary, whenever: (a) Applicable regulations...

30 CFR 1206.265 - Value enhancement of marketable coal.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Value enhancement of marketable coal. 1206.265... INTERIOR Natural Resources Revenue PRODUCT VALUATION Federal Coal § 1206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after...

40 CFR 265.114 - Disposal or decontamination of equipment, structures and soils.

Code of Federal Regulations, 2010 CFR

2010-07-01

... equipment, structures and soils. 265.114 Section 265.114 Protection of Environment ENVIRONMENTAL PROTECTION... decontamination of equipment, structures and soils. During the partial and final closure periods, all contaminated equipment, structures and soil must be properly disposed of, or decontaminated unless specified otherwise in...

40 CFR 265.114 - Disposal or decontamination of equipment, structures and soils.

Code of Federal Regulations, 2012 CFR

2012-07-01

... equipment, structures and soils. 265.114 Section 265.114 Protection of Environment ENVIRONMENTAL PROTECTION... decontamination of equipment, structures and soils. During the partial and final closure periods, all contaminated equipment, structures and soil must be properly disposed of, or decontaminated unless specified otherwise in...

40 CFR 265.114 - Disposal or decontamination of equipment, structures and soils.

Code of Federal Regulations, 2011 CFR

2011-07-01

... equipment, structures and soils. 265.114 Section 265.114 Protection of Environment ENVIRONMENTAL PROTECTION... decontamination of equipment, structures and soils. During the partial and final closure periods, all contaminated equipment, structures and soil must be properly disposed of, or decontaminated unless specified otherwise in...

40 CFR 265.114 - Disposal or decontamination of equipment, structures and soils.

Code of Federal Regulations, 2013 CFR

2013-07-01

... equipment, structures and soils. 265.114 Section 265.114 Protection of Environment ENVIRONMENTAL PROTECTION... decontamination of equipment, structures and soils. During the partial and final closure periods, all contaminated equipment, structures and soil must be properly disposed of, or decontaminated unless specified otherwise in...

40 CFR 265.114 - Disposal or decontamination of equipment, structures and soils.

Code of Federal Regulations, 2014 CFR

2014-07-01

... equipment, structures and soils. 265.114 Section 265.114 Protection of Environment ENVIRONMENTAL PROTECTION... decontamination of equipment, structures and soils. During the partial and final closure periods, all contaminated equipment, structures and soil must be properly disposed of, or decontaminated unless specified otherwise in...

12 CFR 265.2 - Delegation of functions generally.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Delegation of functions generally. 265.2... RESERVE SYSTEM RULES REGARDING DELEGATION OF AUTHORITY § 265.2 Delegation of functions generally. (a) The Board has determined to delegate authority to exercise the functions described in this part. (b) The...

40 CFR 265.117 - Post-closure care and use of property.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 265.117 Section 265.117 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID.... (a)(1) Post-closure care for each hazardous waste management unit subject to the requirements of... this part. (2) Any time preceding closure of a hazardous waste management unit subject to post-closure...

14 CFR 125.265 - Flight engineer requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight engineer requirements. 125.265... Requirements § 125.265 Flight engineer requirements. (a) No person may operate an airplane for which a flight engineer is required by the type certification requirements without a flight crewmember holding a current...

14 CFR 125.265 - Flight engineer requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight engineer requirements. 125.265... Requirements § 125.265 Flight engineer requirements. (a) No person may operate an airplane for which a flight engineer is required by the type certification requirements without a flight crewmember holding a current...

14 CFR 125.265 - Flight engineer requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight engineer requirements. 125.265... Requirements § 125.265 Flight engineer requirements. (a) No person may operate an airplane for which a flight engineer is required by the type certification requirements without a flight crewmember holding a current...

15 CFR 265.13 - Emergency vehicles.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Emergency vehicles. 265.13 Section 265.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE... Emergency vehicles. No person shall fail or refuse to yield the right-of-way to an emergency vehicle when...

15 CFR 265.13 - Emergency vehicles.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Emergency vehicles. 265.13 Section 265.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE... Emergency vehicles. No person shall fail or refuse to yield the right-of-way to an emergency vehicle when...

15 CFR 265.13 - Emergency vehicles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Emergency vehicles. 265.13 Section 265.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE... Emergency vehicles. No person shall fail or refuse to yield the right-of-way to an emergency vehicle when...

15 CFR 265.13 - Emergency vehicles.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Emergency vehicles. 265.13 Section 265.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE... Emergency vehicles. No person shall fail or refuse to yield the right-of-way to an emergency vehicle when...

15 CFR 265.13 - Emergency vehicles.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Emergency vehicles. 265.13 Section 265.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE... Emergency vehicles. No person shall fail or refuse to yield the right-of-way to an emergency vehicle when...

40 CFR 265.91 - Ground-water monitoring system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Ground-water monitoring system. 265.91... DISPOSAL FACILITIES Ground-Water Monitoring § 265.91 Ground-water monitoring system. (a) A ground-water monitoring system must be capable of yielding ground-water samples for analysis and must consist of: (1...

15 CFR 265.39 - Weapons and explosives.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Weapons and explosives. 265.39 Section..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.39 Weapons and... dangerous or deadly weapons or materials, or explosives, either openly or concealed, without the written...

15 CFR 265.39 - Weapons and explosives.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Weapons and explosives. 265.39 Section..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.39 Weapons and... dangerous or deadly weapons or materials, or explosives, either openly or concealed, without the written...

15 CFR 265.39 - Weapons and explosives.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Weapons and explosives. 265.39 Section..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.39 Weapons and... dangerous or deadly weapons or materials, or explosives, either openly or concealed, without the written...

15 CFR 265.39 - Weapons and explosives.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Weapons and explosives. 265.39 Section..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.39 Weapons and... dangerous or deadly weapons or materials, or explosives, either openly or concealed, without the written...

24 CFR 241.265 - Insurance of property against flood.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance of property against flood. 241.265 Section 241.265 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance of property against flood. The mortgaged property shall be insured against flood as stipulated by...

15 CFR 265.42 - Photography for advertising or commercial purposes; advertising and soliciting.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Photography for advertising or commercial purposes; advertising and soliciting. 265.42 Section 265.42 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF...

21 CFR 26.5 - Length of transition period.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Length of transition period. 26.5 Section 26.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS...

40 CFR 265.171 - Condition of containers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Condition of containers. 265.171... DISPOSAL FACILITIES Use and Management of Containers § 265.171 Condition of containers. If a container... transfer the hazardous waste from this container to a container that is in good condition, or manage the...

40 CFR 265.173 - Management of containers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Management of containers. 265.173... DISPOSAL FACILITIES Use and Management of Containers § 265.173 Management of containers. (a) A container... waste. (b) A container holding hazardous waste must not be opened, handled, or stored in a manner which...

40 CFR 265.51 - Purpose and implementation of contingency plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Purpose and implementation of contingency plan. 265.51 Section 265.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... contingency plan must be designed to minimize hazards to human health or the environment from fires...

40 CFR 265.281 - Special requirements for ignitable or reactive waste.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Special requirements for ignitable or reactive waste. 265.281 Section 265.281 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... waste is immediately incorporated into the soil so that: (1) The resulting waste, mixture, or...

14 CFR 125.265 - Flight engineer requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight engineer requirements. 125.265... Requirements § 125.265 Flight engineer requirements. (a) No person may operate an airplane for which a flight engineer is required by the type certification requirements without a flight crewmember holding a current...

14 CFR 125.265 - Flight engineer requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight engineer requirements. 125.265... Requirements § 125.265 Flight engineer requirements. (a) No person may operate an airplane for which a flight engineer is required by the type certification requirements without a flight crewmember holding a current...

29 CFR 1952.265 - Level of Federal enforcement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Level of Federal enforcement. 1952.265 Section 1952.265 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... Level of Federal enforcement. Pursuant to §§ 1902.20(b)(1)(iii) and 1954.3 of this chapter under which...

25 CFR 265.3 - Roads prohibited.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Roads prohibited. 265.3 Section 265.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS..., unless the requirements of fire protection, commercial use for the Indians' benefit or actual needs of...

25 CFR 265.3 - Roads prohibited.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Roads prohibited. 265.3 Section 265.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS..., unless the requirements of fire protection, commercial use for the Indians' benefit or actual needs of...

25 CFR 265.3 - Roads prohibited.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Roads prohibited. 265.3 Section 265.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS..., unless the requirements of fire protection, commercial use for the Indians' benefit or actual needs of...

25 CFR 265.3 - Roads prohibited.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Roads prohibited. 265.3 Section 265.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS..., unless the requirements of fire protection, commercial use for the Indians' benefit or actual needs of...

25 CFR 265.3 - Roads prohibited.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Roads prohibited. 265.3 Section 265.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HERITAGE PRESERVATION ESTABLISHMENT OF ROADLESS AND WILD AREAS..., unless the requirements of fire protection, commercial use for the Indians' benefit or actual needs of...

40 CFR 265.91 - Ground-water monitoring system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Ground-water monitoring system. 265.91... DISPOSAL FACILITIES Ground-Water Monitoring § 265.91 Ground-water monitoring system. (a) A ground-water monitoring system must be capable of yielding ground-water samples for analysis and must consist of: (1...

40 CFR 265.91 - Ground-water monitoring system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Ground-water monitoring system. 265.91... DISPOSAL FACILITIES Ground-Water Monitoring § 265.91 Ground-water monitoring system. (a) A ground-water monitoring system must be capable of yielding ground-water samples for analysis and must consist of: (1...

40 CFR 265.91 - Ground-water monitoring system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Ground-water monitoring system. 265.91... DISPOSAL FACILITIES Ground-Water Monitoring § 265.91 Ground-water monitoring system. (a) A ground-water monitoring system must be capable of yielding ground-water samples for analysis and must consist of: (1...

40 CFR 761.265 - Sampling bulk PCB remediation waste and porous surfaces.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Sampling bulk PCB remediation waste and porous surfaces. 761.265 Section 761.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., DISTRIBUTION IN COMMERCE, AND USE PROHIBITIONS Cleanup Site Characterization Sampling for PCB Remediation Waste...

40 CFR 761.265 - Sampling bulk PCB remediation waste and porous surfaces.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Sampling bulk PCB remediation waste and porous surfaces. 761.265 Section 761.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., DISTRIBUTION IN COMMERCE, AND USE PROHIBITIONS Cleanup Site Characterization Sampling for PCB Remediation Waste...

40 CFR 761.265 - Sampling bulk PCB remediation waste and porous surfaces.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Sampling bulk PCB remediation waste and porous surfaces. 761.265 Section 761.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., DISTRIBUTION IN COMMERCE, AND USE PROHIBITIONS Cleanup Site Characterization Sampling for PCB Remediation Waste...

40 CFR 761.265 - Sampling bulk PCB remediation waste and porous surfaces.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Sampling bulk PCB remediation waste and porous surfaces. 761.265 Section 761.265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., DISTRIBUTION IN COMMERCE, AND USE PROHIBITIONS Cleanup Site Characterization Sampling for PCB Remediation Waste...

33 CFR 105.265 - Security measures for handling cargo.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., containers, or other cargo transport units entering the facility match the delivery note or equivalent cargo..., containers or other cargo transport units, and cargo storage areas within the facility for evidence of... cargo. 105.265 Section 105.265 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

33 CFR 105.265 - Security measures for handling cargo.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., containers, or other cargo transport units entering the facility match the delivery note or equivalent cargo..., containers or other cargo transport units, and cargo storage areas within the facility for evidence of... cargo. 105.265 Section 105.265 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

33 CFR 105.265 - Security measures for handling cargo.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., containers, or other cargo transport units entering the facility match the delivery note or equivalent cargo..., containers or other cargo transport units, and cargo storage areas within the facility for evidence of... cargo. 105.265 Section 105.265 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

33 CFR 105.265 - Security measures for handling cargo.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., containers, or other cargo transport units entering the facility match the delivery note or equivalent cargo..., containers or other cargo transport units, and cargo storage areas within the facility for evidence of... cargo. 105.265 Section 105.265 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

33 CFR 105.265 - Security measures for handling cargo.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., containers, or other cargo transport units entering the facility match the delivery note or equivalent cargo..., containers or other cargo transport units, and cargo storage areas within the facility for evidence of... cargo. 105.265 Section 105.265 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

5. PART 2 OF 3 PART PANORAMA WITH NOS. CA265J4 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. PART 2 OF 3 PART PANORAMA WITH NOS. CA-265-J-4 AND CA-265-J-6 OF FIGUEROA STREET AND LOS ANGELES RIVER VIADUCTS. LOOKING 308°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

40 CFR 265.402 - Waste analysis and trial tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility.] ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Chemical, Physical, and Biological Treatment § 265.402 Waste analysis and trial tests...

40 CFR 265.402 - Waste analysis and trial tests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility.] ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Chemical, Physical, and Biological Treatment § 265.402 Waste analysis and trial tests...

40 CFR 265.402 - Waste analysis and trial tests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility.] ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Chemical, Physical, and Biological Treatment § 265.402 Waste analysis and trial tests...

31 CFR 26.5 - Upgrades and additional environmental information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information. 26.5 Section 26.5 Money and Finance: Treasury Office of the Secretary of the Treasury... environmental information. (a) Environmental category upgrades. If the WGMA and the Department of the Treasury... environmental analysis planned by the MDB is insufficient, the Department of the Treasury will instruct the...

31 CFR 26.5 - Upgrades and additional environmental information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... information. 26.5 Section 26.5 Money and Finance: Treasury Office of the Secretary of the Treasury... environmental information. (a) Environmental category upgrades. If the WGMA and the Department of the Treasury... environmental analysis planned by the MDB is insufficient, the Department of the Treasury will instruct the...

40 CFR 265.402 - Waste analysis and trial tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility.] ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Chemical, Physical, and Biological Treatment § 265.402 Waste analysis and trial tests...

31 CFR 26.5 - Upgrades and additional environmental information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... information. 26.5 Section 26.5 Money and Finance: Treasury Office of the Secretary of the Treasury... environmental information. (a) Environmental category upgrades. If the WGMA and the Department of the Treasury... environmental analysis planned by the MDB is insufficient, the Department of the Treasury will instruct the...

40 CFR 265.402 - Waste analysis and trial tests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility.] ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Chemical, Physical, and Biological Treatment § 265.402 Waste analysis and trial tests...

40 CFR 265.229 - Special requirements for ignitable or reactive waste.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Special requirements for ignitable or reactive waste. 265.229 Section 265.229 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... qualified chemist or engineer that, to the best of his knowledge and opinion, the design features or...

40 CFR 265.13 - General waste analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false General waste analysis. 265.13 Section... FACILITIES General Facility Standards § 265.13 General waste analysis. (a)(1) Before an owner or operator...(d), he must obtain a detailed chemical and physical analysis of a representative sample of the...

20 CFR 416.265 - Requirements for the special SSI eligibility status.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Requirements for the special SSI eligibility status. 416.265 Section 416.265 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

20 CFR 416.265 - Requirements for the special SSI eligibility status.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Requirements for the special SSI eligibility status. 416.265 Section 416.265 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

20 CFR 416.265 - Requirements for the special SSI eligibility status.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Requirements for the special SSI eligibility status. 416.265 Section 416.265 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

6. SITE OVERVIEW. PART 1 OF 6 PART PANORAMA WITH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. SITE OVERVIEW. PART 1 OF 6 PART PANORAMA WITH NOS. CA-265-7 TO CA-265-11. ARROYO SECO PARKWAY AS SEEN FROM RADIO TOWER HILL (APPROXIMATELY 34° 5' BY 118° 12'30" ON USGS LOS ANGELES QUADRANGLE). PART 1 SHOWS GRAND VIEW POINT AT RIGHT REAR (LOCATION OF CAMERA POSITION FOR PHOTOGRAPHS NOS. 265-1 TO CA-265-5) AND FIGUEROA VIADUCT OVERCROSSING; DOWNTOWN LOS ANGELES IS AT LEFT REAR. LOOKING 234° SW. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

30 CFR 206.265 - Value enhancement of marketable coal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Value enhancement of marketable coal. 206.265... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been placed in...

30 CFR 1206.265 - Value enhancement of marketable coal.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Value enhancement of marketable coal. 1206.265... RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been...

30 CFR 1206.265 - Value enhancement of marketable coal.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Value enhancement of marketable coal. 1206.265... RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been...

30 CFR 1206.265 - Value enhancement of marketable coal.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Value enhancement of marketable coal. 1206.265... RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been...

40 CFR 265.92 - Sampling and analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Sampling and analysis. 265.92 Section... FACILITIES Ground-Water Monitoring § 265.92 Sampling and analysis. (a) The owner or operator must obtain and... follow a ground-water sampling and analysis plan. He must keep this plan at the facility. The plan must...

40 CFR 265.92 - Sampling and analysis.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Sampling and analysis. 265.92 Section... FACILITIES Ground-Water Monitoring § 265.92 Sampling and analysis. (a) The owner or operator must obtain and... follow a ground-water sampling and analysis plan. He must keep this plan at the facility. The plan must...

27 CFR 24.265 - Losses by theft.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Losses by theft. 24.265... OF THE TREASURY LIQUORS WINE Losses of Wine § 24.265 Losses by theft. The proprietor shall be liable... to the satisfaction of the appropriate TTB officer that the theft did not occur as the result of...

40 CFR 265.144 - Cost estimate for post-closure care.

Code of Federal Regulations, 2012 CFR

2012-07-01

... comply with § 265.145. For owners or operators using the financial test or corporate guarantee, the post... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Cost estimate for post-closure care..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.144 Cost estimate for post-closure care. (a...

40 CFR 265.144 - Cost estimate for post-closure care.

Code of Federal Regulations, 2010 CFR

2010-07-01

... comply with § 265.145. For owners or operators using the financial test or corporate guarantee, the post... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Cost estimate for post-closure care..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.144 Cost estimate for post-closure care. (a...

40 CFR 265.144 - Cost estimate for post-closure care.

Code of Federal Regulations, 2013 CFR

2013-07-01

... comply with § 265.145. For owners or operators using the financial test or corporate guarantee, the post... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Cost estimate for post-closure care..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.144 Cost estimate for post-closure care. (a...

40 CFR 265.144 - Cost estimate for post-closure care.

Code of Federal Regulations, 2011 CFR

2011-07-01

... comply with § 265.145. For owners or operators using the financial test or corporate guarantee, the post... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Cost estimate for post-closure care..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.144 Cost estimate for post-closure care. (a...

40 CFR 265.144 - Cost estimate for post-closure care.

Code of Federal Regulations, 2014 CFR

2014-07-01

... comply with § 265.145. For owners or operators using the financial test or corporate guarantee, the post... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Cost estimate for post-closure care..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.144 Cost estimate for post-closure care. (a...

40 CFR 265.257 - Special requirements for incompatible wastes.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., STORAGE, AND DISPOSAL FACILITIES Waste Piles § 265.257 Special requirements for incompatible wastes. (a... the same pile, unless § 265.17(b) is complied with. (b) A pile of hazardous waste that is incompatible with any waste or other material stored nearby in other containers, piles, open tanks, or surface...

40 CFR 265.252 - Waste analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FACILITIES Waste Piles § 265.252 Waste analysis. In addition to the waste analyses required by § 265.13, the... adding the waste to any existing pile, unless (1) The only wastes the facility receives which are... in the pile to which it is to be added. The analysis conducted must be capable of differentiating...

40 CFR 265.251 - Protection from wind.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Protection from wind. 265.251 Section... FACILITIES Waste Piles § 265.251 Protection from wind. The owner or operator of a pile containing hazardous waste which could be subject to dispersal by wind must cover or otherwise manage the pile so that wind...

40 CFR 265.251 - Protection from wind.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Protection from wind. 265.251 Section... FACILITIES Waste Piles § 265.251 Protection from wind. The owner or operator of a pile containing hazardous waste which could be subject to dispersal by wind must cover or otherwise manage the pile so that wind...

40 CFR 265.251 - Protection from wind.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Protection from wind. 265.251 Section... FACILITIES Waste Piles § 265.251 Protection from wind. The owner or operator of a pile containing hazardous waste which could be subject to dispersal by wind must cover or otherwise manage the pile so that wind...

45 CFR 153.265 - Restrictions on use of reinsurance funds for administrative expenses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Restrictions on use of reinsurance funds for administrative expenses. 153.265 Section 153.265 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK...

12 CFR 265.8 - Functions delegated to the Staff Director of the Division of International Finance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the Division of International Finance. 265.8 Section 265.8 Banks and Banking FEDERAL RESERVE SYSTEM... Functions delegated to the Staff Director of the Division of International Finance. The Board's Staff Director of the Division of International Finance (or the Director's delegee) is authorized: (a...

40 CFR 265.442 - Design and installation of new drip pads.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Design and installation of new drip pads. 265.442 Section 265.442 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Drip Pads §...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.53 - Copies of contingency plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Copies of contingency plan. 265.53... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.53 Copies of contingency plan. A copy of the contingency plan and all revisions to the plan must be: (a) Maintained at the facility; and (b...

40 CFR 265.53 - Copies of contingency plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Copies of contingency plan. 265.53... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.53 Copies of contingency plan. A copy of the contingency plan and all revisions to the plan must be: (a) Maintained at the facility; and (b...

40 CFR 265.53 - Copies of contingency plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Copies of contingency plan. 265.53... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.53 Copies of contingency plan. A copy of the contingency plan and all revisions to the plan must be: (a) Maintained at the facility; and (b...

40 CFR 265.53 - Copies of contingency plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Copies of contingency plan. 265.53... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.53 Copies of contingency plan. A copy of the contingency plan and all revisions to the plan must be: (a) Maintained at the facility; and (b...

21 CFR 1271.265 - Receipt, predistribution shipment, and distribution of an HCT/P.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Receipt, predistribution shipment, and distribution of an HCT/P. 1271.265 Section 1271.265 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND...

40 CFR 265.200 - Waste analysis and trial tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... operator to place the results from each waste analysis and trial test, or the documented information, in... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Tank Systems § 265.200 Waste analysis and trial tests. In addition to performing the...

40 CFR 265.225 - Waste analysis and trial tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Surface Impoundments § 265.225 Waste analysis and trial tests. (a) In addition to the...

40 CFR 265.225 - Waste analysis and trial tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Surface Impoundments § 265.225 Waste analysis and trial tests. (a) In addition to the...

40 CFR 265.225 - Waste analysis and trial tests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Surface Impoundments § 265.225 Waste analysis and trial tests. (a) In addition to the...

40 CFR 265.225 - Waste analysis and trial tests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Surface Impoundments § 265.225 Waste analysis and trial tests. (a) In addition to the...

40 CFR 265.200 - Waste analysis and trial tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... operator to place the results from each waste analysis and trial test, or the documented information, in... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Tank Systems § 265.200 Waste analysis and trial tests. In addition to performing the...

40 CFR 265.225 - Waste analysis and trial tests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... waste analysis and trial test, or the documented information, in the operating record of the facility... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Surface Impoundments § 265.225 Waste analysis and trial tests. (a) In addition to the...

40 CFR 265.200 - Waste analysis and trial tests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... operator to place the results from each waste analysis and trial test, or the documented information, in... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Tank Systems § 265.200 Waste analysis and trial tests. In addition to performing the...

40 CFR 265.200 - Waste analysis and trial tests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... operator to place the results from each waste analysis and trial test, or the documented information, in... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Tank Systems § 265.200 Waste analysis and trial tests. In addition to performing the...

40 CFR 265.200 - Waste analysis and trial tests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... operator to place the results from each waste analysis and trial test, or the documented information, in... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Tank Systems § 265.200 Waste analysis and trial tests. In addition to performing the...

40 CFR 265.383 - Interim status thermal treatment devices burning particular hazardous waste.

Code of Federal Regulations, 2010 CFR

2010-07-01

... devices burning particular hazardous waste. 265.383 Section 265.383 Protection of Environment... status thermal treatment devices burning particular hazardous waste. (a) Owners or operators of thermal treatment devices subject to this subpart may burn EPA Hazardous Wastes FO20, FO21, FO22, FO23, FO26, or...

40 CFR 265.383 - Interim status thermal treatment devices burning particular hazardous waste.

Code of Federal Regulations, 2013 CFR

2013-07-01

... devices burning particular hazardous waste. 265.383 Section 265.383 Protection of Environment... status thermal treatment devices burning particular hazardous waste. (a) Owners or operators of thermal treatment devices subject to this subpart may burn EPA Hazardous Wastes FO20, FO21, FO22, FO23, FO26, or...

40 CFR 265.383 - Interim status thermal treatment devices burning particular hazardous waste.

Code of Federal Regulations, 2014 CFR

2014-07-01

... devices burning particular hazardous waste. 265.383 Section 265.383 Protection of Environment... status thermal treatment devices burning particular hazardous waste. (a) Owners or operators of thermal treatment devices subject to this subpart may burn EPA Hazardous Wastes FO20, FO21, FO22, FO23, FO26, or...

40 CFR 265.383 - Interim status thermal treatment devices burning particular hazardous waste.

Code of Federal Regulations, 2012 CFR

2012-07-01

... devices burning particular hazardous waste. 265.383 Section 265.383 Protection of Environment... status thermal treatment devices burning particular hazardous waste. (a) Owners or operators of thermal treatment devices subject to this subpart may burn EPA Hazardous Wastes FO20, FO21, FO22, FO23, FO26, or...

40 CFR 265.383 - Interim status thermal treatment devices burning particular hazardous waste.

Code of Federal Regulations, 2011 CFR

2011-07-01

... devices burning particular hazardous waste. 265.383 Section 265.383 Protection of Environment... status thermal treatment devices burning particular hazardous waste. (a) Owners or operators of thermal treatment devices subject to this subpart may burn EPA Hazardous Wastes FO20, FO21, FO22, FO23, FO26, or...

40 CFR 265.251 - Protection from wind.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Protection from wind. 265.251 Section... FACILITIES Waste Piles § 265.251 Protection from wind. The owner or operator of a pile containing hazardous waste which could be subject to dispersal by wind must cover or otherwise manage the pile so that wind...

40 CFR 265.251 - Protection from wind.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Protection from wind. 265.251 Section... FACILITIES Waste Piles § 265.251 Protection from wind. The owner or operator of a pile containing hazardous waste which could be subject to dispersal by wind must cover or otherwise manage the pile so that wind...

40 CFR 265.310 - Closure and post-closure care.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Closure and post-closure care. 265.310... DISPOSAL FACILITIES Landfills § 265.310 Closure and post-closure care. (a) At final closure of the landfill... subsoils present. (b) After final closure, the owner or operator must comply with all post-closure...

40 CFR 265.310 - Closure and post-closure care.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Closure and post-closure care. 265.310... DISPOSAL FACILITIES Landfills § 265.310 Closure and post-closure care. (a) At final closure of the landfill... subsoils present. (b) After final closure, the owner or operator must comply with all post-closure...

40 CFR 265.310 - Closure and post-closure care.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Closure and post-closure care. 265.310... DISPOSAL FACILITIES Landfills § 265.310 Closure and post-closure care. (a) At final closure of the landfill... subsoils present. (b) After final closure, the owner or operator must comply with all post-closure...

40 CFR 265.53 - Copies of contingency plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Copies of contingency plan. 265.53... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.53 Copies of contingency plan. A copy of the contingency plan and all revisions to the plan must be: (a) Maintained at the facility; and (b...

The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii▿ §

PubMed Central

Ngamskulrungroj, Popchai; Himmelreich, Uwe; Breger, Julia A.; Wilson, Christabel; Chayakulkeeree, Methee; Krockenberger, Mark B.; Malik, Richard; Daniel, Heide-Marie; Toffaletti, Dena; Djordjevic, Julianne T.; Mylonakis, Eleftherios; Meyer, Wieland; Perfect, John R.

2009-01-01

The trehalose pathway is essential for stress tolerance and virulence in fungi. We investigated the importance of this pathway for virulence of the pathogenic yeast Cryptococcus gattii using the highly virulent Vancouver Island, Canada, outbreak strain R265. Three genes putatively involved in trehalose biosynthesis, TPS1 (trehalose-6-phosphate [T6P] synthase) and TPS2 (T6P phosphatase), and degradation, NTH1 (neutral trehalose), were deleted in this strain, creating the R265tps1Δ, R265tps2Δ, and R265nth1Δ mutants. As in Cryptococcus neoformans, cellular trehalose was reduced in the R265tps1Δ and R265tps2Δ mutants, which could not grow and died, respectively, at 37°C on yeast extract-peptone-dextrose agar, suggesting that T6P accumulation in R265tps2Δ is directly toxic. Characterizations of the cryptococcal hexokinases and trehalose mutants support their linkage to the control of glycolysis in this species. However, unlike C. neoformans, the C. gattii R265tps1Δ mutant demonstrated, in addition, defects in melanin and capsule production, supporting an influence of T6P on these virulence pathways. Attenuated virulence of the R265tps1Δ mutant was not due solely to its 37°C growth defect, as shown in worm studies and confirmed by suppressor mutants. Furthermore, an intact trehalose pathway controls protein secretion, mating, and cell wall integrity in C. gattii. Thus, the trehalose synthesis pathway plays a central role in the virulence composites of C. gattii through multiple mechanisms. Deletion of NTH1 had no effect on virulence, but inactivation of the synthesis genes, TPS1 and TPS2, has profound effects on survival of C. gattii in the invertebrate and mammalian hosts. These results highlight the central importance of this pathway in the virulence composites of both pathogenic cryptococcal species. PMID:19651856

Differences between Cryptococcus neoformans and Cryptococcus gattii in the Molecular Mechanisms Governing Utilization of D-Amino Acids as the Sole Nitrogen Source

PubMed Central

Chang, Yun C.; Khanal Lamichhane, Ami; Bradley, James; Rodgers, Laura; Ngamskulrungroj, Popchai; Kwon-Chung, Kyung J.

2015-01-01

The ability to grow on media containing certain D-amino acids as a sole nitrogen source is widely utilized to differentiate Cryptococcus gattii from C. neoformans. We used the C. neoformans H99 and C. gattii R265 strains to dissect the mechanisms of D-amino acids utilization. We identified three putative D-amino acid oxidase (DAO) genes in both strains and showed that each DAO gene plays different roles in D-amino acid utilization in each strain. Deletion of DAO2 retarded growth of R265 on eleven D-amino acids suggesting its prominent role on D-amino acid assimilation in R265. All three R265 DAO genes contributed to growth on D-Asn and D-Asp. DAO3 was required for growth and detoxification of D-Glu by both R265 and H99. Although growth of H99 on most D-amino acids was poor, deletion of DAO1 or DAO3 further exacerbated it on four D-amino acids. Overexpression of DAO2 or DAO3 enabled H99 to grow robustly on several D-amino acids suggesting that expression levels of the native DAO genes in H99 were insufficient for growth on D-amino acids. Replacing the H99 DAO2 gene with a single copy of the R265 DAO2 gene also enabled its utilization of several D-amino acids. Results of gene and promoter swaps of the DAO2 genes suggested that enzymatic activity of Dao2 in H99 might be lower compared to the R265 strain. A reduction in virulence was only observed when all DAO genes were deleted in R265 but not in H99 indicating a pathobiologically exclusive role of the DAO genes in R265. These results suggest that C. neoformans and C. gattii divergently evolved in D-amino acid utilization influenced by their major ecological niches. PMID:26132227

46 CFR 107.265 - Special examination in lieu of drydocking for column stabilized units or surface type units when...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Special examination in lieu of drydocking for column stabilized units or surface type units when specifically approved by the Commandant. 107.265 Section 107.265 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS...

46 CFR 107.265 - Special examination in lieu of drydocking for column stabilized units or surface type units when...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Special examination in lieu of drydocking for column stabilized units or surface type units when specifically approved by the Commandant. 107.265 Section 107.265 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS...

46 CFR 107.265 - Special examination in lieu of drydocking for column stabilized units or surface type units when...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Special examination in lieu of drydocking for column stabilized units or surface type units when specifically approved by the Commandant. 107.265 Section 107.265 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS...

46 CFR 107.265 - Special examination in lieu of drydocking for column stabilized units or surface type units when...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Special examination in lieu of drydocking for column stabilized units or surface type units when specifically approved by the Commandant. 107.265 Section 107.265 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS...

46 CFR 107.265 - Special examination in lieu of drydocking for column stabilized units or surface type units when...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Special examination in lieu of drydocking for column stabilized units or surface type units when specifically approved by the Commandant. 107.265 Section 107.265 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS...

20 CFR 645.265 - What safeguards are there to ensure that participants in Welfare-to-Work employment activities do...

Code of Federal Regulations, 2010 CFR

2010-04-01

... participants in Welfare-to-Work employment activities do not displace other employees? 645.265 Section 645.265 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE... ensure that participants in Welfare-to-Work employment activities do not displace other employees? (a) An...

40 CFR 265.1057 - Standards: Valves in gas/vapor service or in light liquid service.

Code of Federal Regulations, 2011 CFR

2011-07-01

....1057 Standards: Valves in gas/vapor service or in light liquid service. (a) Each valve in gas/vapor or... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Standards: Valves in gas/vapor service or in light liquid service. 265.1057 Section 265.1057 Protection of Environment ENVIRONMENTAL...

40 CFR 265.1057 - Standards: Valves in gas/vapor service or in light liquid service.

Code of Federal Regulations, 2010 CFR

2010-07-01

....1057 Standards: Valves in gas/vapor service or in light liquid service. (a) Each valve in gas/vapor or... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Standards: Valves in gas/vapor service or in light liquid service. 265.1057 Section 265.1057 Protection of Environment ENVIRONMENTAL...

40 CFR 265.1057 - Standards: Valves in gas/vapor service or in light liquid service.

Code of Federal Regulations, 2012 CFR

2012-07-01

....1057 Standards: Valves in gas/vapor service or in light liquid service. (a) Each valve in gas/vapor or... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Standards: Valves in gas/vapor service or in light liquid service. 265.1057 Section 265.1057 Protection of Environment ENVIRONMENTAL...

40 CFR 265.1057 - Standards: Valves in gas/vapor service or in light liquid service.

Code of Federal Regulations, 2013 CFR

2013-07-01

....1057 Standards: Valves in gas/vapor service or in light liquid service. (a) Each valve in gas/vapor or... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Standards: Valves in gas/vapor service or in light liquid service. 265.1057 Section 265.1057 Protection of Environment ENVIRONMENTAL...

40 CFR 265.1057 - Standards: Valves in gas/vapor service or in light liquid service.

Code of Federal Regulations, 2014 CFR

2014-07-01

....1057 Standards: Valves in gas/vapor service or in light liquid service. (a) Each valve in gas/vapor or... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Standards: Valves in gas/vapor service or in light liquid service. 265.1057 Section 265.1057 Protection of Environment ENVIRONMENTAL...

40 CFR 265.146 - Use of a mechanism for financial assurance of both closure and post-closure care.

Code of Federal Regulations, 2013 CFR

2013-07-01

... assurance of both closure and post-closure care. 265.146 Section 265.146 Protection of Environment... Use of a mechanism for financial assurance of both closure and post-closure care. An owner or operator may satisfy the requirements for financial assurance for both closure and post-closure care for one or...

4. PART 1 OF 3 PART PANORAMA WITH NOS. CA265J5 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. PART 1 OF 3 PART PANORAMA WITH NOS. CA-265-J-5 AND CA-265-J-6 OF FIGUEROA STREET AND LOS ANGELES RIVER VIADUCTS. NOTE TUNNEL NO.1 NORTH PORTAL AT LEFT REAR. LOOKING 268°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

41 CFR 102-34.265 - May we keep a Government-owned motor vehicle even though the standard permits replacement?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May we keep a Government-owned motor vehicle even though the standard permits replacement? 102-34.265 Section 102-34.265 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 34...

45 CFR 265.3 - What reports must the State file on a quarterly basis?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true What reports must the State file on a quarterly basis? 265.3 Section 265.3 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES DATA COLLECTION AND REPORTING...

40 CFR 265.1061 - Alternative standards for valves in gas/vapor service or in light liquid service: percentage of...

Code of Federal Regulations, 2010 CFR

2010-07-01

... gas/vapor service or in light liquid service: percentage of valves allowed to leak. 265.1061 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1061 Alternative standards for valves in gas/vapor service or in light liquid service: percentage of valves allowed to leak. (a) An owner or operator...

40 CFR 265.1061 - Alternative standards for valves in gas/vapor service or in light liquid service: percentage of...

Code of Federal Regulations, 2011 CFR

2011-07-01

... gas/vapor service or in light liquid service: percentage of valves allowed to leak. 265.1061 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1061 Alternative standards for valves in gas/vapor service or in light liquid service: percentage of valves allowed to leak. (a) An owner or operator...

40 CFR 265.1061 - Alternative standards for valves in gas/vapor service or in light liquid service: percentage of...

Code of Federal Regulations, 2012 CFR

2012-07-01

... gas/vapor service or in light liquid service: percentage of valves allowed to leak. 265.1061 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1061 Alternative standards for valves in gas/vapor service or in light liquid service: percentage of valves allowed to leak. (a) An owner or operator...

40 CFR 265.1062 - Alternative standards for valves in gas/vapor service or in light liquid service: skip period...

Code of Federal Regulations, 2014 CFR

2014-07-01

... gas/vapor service or in light liquid service: skip period leak detection and repair. 265.1062 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1062 Alternative standards for valves in gas/vapor service or in light liquid service: skip period leak detection and repair. (a) An owner or...

40 CFR 265.1062 - Alternative standards for valves in gas/vapor service or in light liquid service: skip period...

Code of Federal Regulations, 2011 CFR

2011-07-01

... gas/vapor service or in light liquid service: skip period leak detection and repair. 265.1062 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1062 Alternative standards for valves in gas/vapor service or in light liquid service: skip period leak detection and repair. (a) An owner or...

40 CFR 265.1062 - Alternative standards for valves in gas/vapor service or in light liquid service: skip period...

Code of Federal Regulations, 2010 CFR

2010-07-01

... gas/vapor service or in light liquid service: skip period leak detection and repair. 265.1062 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1062 Alternative standards for valves in gas/vapor service or in light liquid service: skip period leak detection and repair. (a) An owner or...

40 CFR 265.1062 - Alternative standards for valves in gas/vapor service or in light liquid service: skip period...

Code of Federal Regulations, 2013 CFR

2013-07-01

... gas/vapor service or in light liquid service: skip period leak detection and repair. 265.1062 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1062 Alternative standards for valves in gas/vapor service or in light liquid service: skip period leak detection and repair. (a) An owner or...

40 CFR 265.1062 - Alternative standards for valves in gas/vapor service or in light liquid service: skip period...

Code of Federal Regulations, 2012 CFR

2012-07-01

... gas/vapor service or in light liquid service: skip period leak detection and repair. 265.1062 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1062 Alternative standards for valves in gas/vapor service or in light liquid service: skip period leak detection and repair. (a) An owner or...

40 CFR 265.1061 - Alternative standards for valves in gas/vapor service or in light liquid service: percentage of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... gas/vapor service or in light liquid service: percentage of valves allowed to leak. 265.1061 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1061 Alternative standards for valves in gas/vapor service or in light liquid service: percentage of valves allowed to leak. (a) An owner or operator...

40 CFR 265.1061 - Alternative standards for valves in gas/vapor service or in light liquid service: percentage of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... gas/vapor service or in light liquid service: percentage of valves allowed to leak. 265.1061 Section... FACILITIES Air Emission Standards for Equipment Leaks § 265.1061 Alternative standards for valves in gas/vapor service or in light liquid service: percentage of valves allowed to leak. (a) An owner or operator...

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.

PubMed

McCarthy, James S; Lotharius, Julie; Rückle, Thomas; Chalon, Stephan; Phillips, Margaret A; Elliott, Suzanne; Sekuloski, Silvana; Griffin, Paul; Ng, Caroline L; Fidock, David A; Marquart, Louise; Williams, Noelle S; Gobeau, Nathalie; Bebrevska, Lidiya; Rosario, Maria; Marsh, Kennan; Möhrle, Jörg J

2017-06-01

DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We investigated the safety, tolerability, and pharmacokinetics of DSM265, and tested its antimalarial activity. Healthy participants aged 18-55 years were enrolled in a two-part study: part 1, a single ascending dose (25-1200 mg), double-blind, randomised, placebo-controlled study, and part 2, an open-label, randomised, active-comparator controlled study, in which participants were inoculated with Plasmodium falciparum induced blood-stage malaria (IBSM) and treated with DSM265 (150 mg) or mefloquine (10 mg/kg). Primary endpoints were DSM265 safety, tolerability, and pharmacokinetics. Randomisation lists were created using a validated, automated system. Both parts were registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12613000522718 (part 1) and number ACTRN12613000527763 (part 2). In part 1, 73 participants were enrolled between April 12, 2013, and July 14, 2015 (DSM265, n=55; placebo, n=18). In part 2, nine participants were enrolled between Sept 30 and Nov 25, 2013 (150 mg DSM265, n=7; 10 mg/kg mefloquine, n=2). In part 1, 117 adverse events were reported; no drug-related serious or severe events were reported. The most common drug-related adverse event was headache. The mean DSM265 peak plasma concentration (C max ) ranged between 1310 ng/mL and 34 800 ng/mL and was reached in a median time (t max ) between 1·5 h and 4 h, with a mean elimination half-life between 86 h and 118 h. In part 2, the log 10 parasite reduction ratio at 48 h in the DSM265 (150 mg) group was 1·55 (95% CI 1·42-1·67) and in the mefloquine (10 mg/kg) group was 2·34 (2·17-2·52), corresponding to a parasite clearance half-life of 9·4 h (8·7-10·2) and 6·2 h (5·7-6·7), respectively. The median minimum inhibitory concentration of DSM265 in blood was estimated as 1040 ng/mL (range 552-1500), resulting in a predicted single efficacious dose of 340 mg. Parasite clearance was significantly faster in participants who received mefloquine than in participants who received DSM265 (p<0·0001). The good safety profile, long elimination half-life, and antimalarial effect of DSM265 supports its development as a partner drug in a single-dose antimalarial combination treatment. Wellcome Trust, UK Department for International Development, Global Health Innovative Technology Fund, Bill & Melinda Gates Foundation. Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.

6. PART 3 OF 3 PART PANORAMA WITH NOS. CA265J4 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. PART 3 OF 3 PART PANORAMA WITH NOS. CA-265-J-4 AND CA-265-J-5 OF FIGUEROA STREET AND LOS ANGELES RIVER VIADUCTS. NOTE ARROYO SECO CHANNEL ENTERING LOS ANGELES RIVER UNDER RAILROAD TRESTLE AT RIGHT. LOOKING 268°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

45 CFR 265.8 - Under what circumstances will we take action to impose a reporting penalty for failure to submit...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Under what circumstances will we take action to impose a reporting penalty for failure to submit quarterly and annual reports? 265.8 Section 265.8 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES,...

Decay properties of {sup 265}Sg(Z=106) and {sup 266}Sg(Z=106)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuerler, A.; Dressler, R.; Eichler, B.

1998-04-01

The presently known most neutron-rich isotopes of element 106 (seaborgium, Sg), {sup 265}Sg and {sup 266}Sg, were produced in the fusion reaction {sup 22}Ne+{sup 248}Cm at beam energies of 121 and 123 MeV. Using the On-Line Gas chemistry Apparatus OLGA, a continuous separation of Sg was achieved within a few seconds. Final products were assayed by {alpha}-particle and spontaneous fission (SF) spectrometry. {sup 265}Sg and {sup 266}Sg were identified by observing time correlated {alpha}-{alpha}-({alpha}) and {alpha}-SF decay chains. A total of 13 correlated decay chains of {sup 265}Sg (with an estimated number of 2.8 random correlations) and 3 decay chainsmore » of {sup 266}Sg (0.6 random correlations) were identified. Deduced decay properties were T{sub 1/2}=7.4{sub {minus}2.7}{sup +3.3} s (68{percent} c.i.) and E{sub {alpha}}=8.69 MeV (8{percent}), 8.76 MeV (23{percent}), 8.84 MeV (46{percent}), and 8.94 MeV (23{percent}) for {sup 265}Sg; and T{sub 1/2}=21{sub {minus}12}{sup +20} s (68{percent} c.i.) and E{sub {alpha}}=8.52 MeV (33{percent}) and 8.77 MeV (66{percent}) for {sup 266}Sg. The resolution of the detectors was between 50{endash}100 keV (full width at half maximum). Upper limits for SF of {le}35{percent} and {le}82{percent} were established for {sup 265}Sg and {sup 266}Sg, respectively. The upper limits for SF are given with a 16{percent} error probability. Using the lower error limits of the half-lives of {sup 265}Sg and {sup 266}Sg, the resulting lower limits for the partial SF half-lives are T{sub 1/2}{sup SF}({sup 265}Sg){ge}13 s and T{sub 1/2}{sup SF}({sup 266}Sg){ge}11 s. Correspondingly, the partial {alpha}-decay half-lives are between T{sub 1/2}{sup {alpha}}({sup 265}Sg)=4.7{endash}16.5 s (68{percent} c.i.) and T{sub 1/2}{sup {alpha}}({sup 266}Sg)=9{endash}228 s (68{percent} c.i.), using the upper and lower error limits of the half-lives of {sup 265}Sg and {sup 266}Sg. The lower limit on the partial SF half-life of {sup 266}Sg is in good agreement with theoretical predictions. Production cross sections of about 240 pb and 25 pb for the {alpha}-decay branch in {sup 265}Sg and {sup 266}Sg were estimated, respectively. {copyright} {ital 1998} {ital The American Physical Society}« less

Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?

PubMed

Nguyen-Dumont, Tú; Teo, Zhi L; Hammet, Fleur; Roberge, Alexis; Mahmoodi, Maryam; Tsimiklis, Helen; Park, Daniel J; Pope, Bernard J; Lonie, Andrew; Kapuscinski, Miroslav K; Mahmood, Khalid; Goldgar, David E; Giles, Graham G; Winship, Ingrid; Hopper, John L; Southey, Melissa C

2018-02-08

Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers of high-risk mutations in other breast cancer susceptibility genes. In a family known to carry the high-risk mutation PALB2:c.3113G>A (p.Trp1038*), whole-exome sequencing was performed on germline DNA from four affected women, three of whom were mutation carriers. RNASEL:p.Glu265* was identified in one of the PALB2 carriers who had two primary invasive breast cancer diagnoses before 50 years. Gene-panel testing of BRCA1, BRCA2, PALB2 and RNASEL in the Australian Breast Cancer Family Registry identified five carriers of RNASEL:p.Glu265* in 591 early onset breast cancer cases. Three of the five women (60%) carrying RNASEL:p.Glu265* also carried a pathogenic mutation in a breast cancer susceptibility gene compared with 30 carriers of pathogenic mutations in the 586 non-carriers of RNASEL:p.Glu265* (5%) (p < 0.002). Taqman genotyping demonstrated that the allele frequency of RNASEL:p.Glu265* was similar in affected and unaffected Australian women, consistent with other populations. Our study suggests that RNASEL:p.Glu265* may be a genetic modifier of risk for early-onset breast cancer predisposition in carriers of high-risk mutations. Much larger case-case and case-control studies are warranted to test the association observed in this report.

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

PubMed Central

Phillips, Margaret A.; White, Karen L.; Kokkonda, Sreekanth; Deng, Xiaoyi; White, John; Mazouni, Farah El; Marsh, Kennan; Tomchick, Diana R.; Manjalanagara, Krishne; Rudra, Kakali Rani; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Shackleford, David M.; Chiu, Francis C.K.; Campbell, Michael; Jimenez-Diaz, Maria Belen; Bazaga, Santiago Ferrer; Angulo-Barturen, Iñigo; Martinez, Maria Santos; Lafuente-Monasterio, Maria; Kaminsky, Werner; Silue, Kigbafori; Zeeman, Anne-Marie; Kocken, Clemens; Leroy, Didier; Blasco, Benjamin; Rossignol, Emilie; Rueckle, Thomas; Matthews, Dave; Burrows, Jeremy N.; Waterson, David; Palmer, Michael J.; Rathod, Pradipsinh K.; Charman, Susan A.

2016-01-01

The emergence of drug resistant malaria parasites continues to hamper efforts to control this lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target for the treatment of malaria and a selective inhibitor (DSM265) of the Plasmodium enzyme is currently in clinical development. With the goal of identifying a backup compound to DSM265, we explored replacement of the SF5-aniline moiety of DSM265 with a series of CF3-pyridinyls, while maintaining the core triazolopyrimidine scaffold. This effort led to the identification of DSM421, which has improved solubility, lower intrinsic clearance and increased plasma exposure after oral dosing compared to DSM265, while maintaining a long predicted human half-life. Its improved physical and chemical properties will allow it to be formulated more readily than DSM265. DSM421 showed excellent efficacy in the SCID mouse model of P. falciparum malaria that supports the prediction of a low human dose (<200 mg). Importantly DSM421 showed equal activity against both P. falciparum and P. vivax field isolates, while DSM265 was more active on P. falciparum. DSM421 has the potential to be developed as a single dose cure or once-weekly chemopreventative for both P. falciparum and P. vivax malaria leading to its advancement as a preclinical development candidate. PMID:27641613

40 CFR 265.404 - Closure.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., Physical, and Biological Treatment § 265.404 Closure. At closure, all hazardous waste and hazardous waste residues must be removed from treatment processes or equipment, discharge control equipment, and discharge...

40 CFR 265.404 - Closure.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., Physical, and Biological Treatment § 265.404 Closure. At closure, all hazardous waste and hazardous waste residues must be removed from treatment processes or equipment, discharge control equipment, and discharge...

40 CFR 265.404 - Closure.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., Physical, and Biological Treatment § 265.404 Closure. At closure, all hazardous waste and hazardous waste residues must be removed from treatment processes or equipment, discharge control equipment, and discharge...

40 CFR 265.404 - Closure.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Physical, and Biological Treatment § 265.404 Closure. At closure, all hazardous waste and hazardous waste residues must be removed from treatment processes or equipment, discharge control equipment, and discharge...

40 CFR 265.404 - Closure.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Physical, and Biological Treatment § 265.404 Closure. At closure, all hazardous waste and hazardous waste residues must be removed from treatment processes or equipment, discharge control equipment, and discharge...

Identification of Two Meloidogyne hapla Genes and an Investigation of Their Roles in the Plant-Nematode Interaction.

PubMed

Gleason, Cynthia; Polzin, Frederik; Habash, Samer S; Zhang, Lei; Utermark, Jan; Grundler, Florian M W; Elashry, Abdelnaser

2017-02-01

Root-knot nematodes are soil-borne pathogens that invade and establish feeding sites in plant roots. They have an extremely broad host range, including most vascular plants. During infection of a susceptible host, root-knot nematodes secrete molecules called effectors that help them establish an intimate interaction with the plant and, at the same time, allow them to evade or suppress plant immune responses. Despite the fact that Meloidogyne hapla is a significant pest on several food crops, no effectors have been characterized from this root-knot nematode species thus far. Using the published genome and proteome from M. hapla, we have identified and characterized two genes, MhTTL2 and Mh265. MhTTL2 encodes a predicted secreted protein containing a transthyretin-like protein domain. The expression of MhTTL2 was up-regulated during parasitic life stages of the nematode, and in situ hybridization showed that MhTTL2 was expressed in the amphids, suggesting it has a role in the nematode nervous system during parasitism. We also studied the gene Mh265. The Mh265 transcript was localized to the subventral esophageal glands. An upregulation in Mh265 expression coincided with the pre- and early-parasitic life stages of the nematode. When Mh265 was constitutively expressed in plants, it enhanced their susceptibility to nematodes. These transgenic plants were also compromised in flg22-induced callose deposition, suggesting the Mh265 is modulating plant basal immune responses.

Video traffic characteristics of modern encoding standards: H.264/AVC with SVC and MVC extensions and H.265/HEVC.

PubMed

Seeling, Patrick; Reisslein, Martin

2014-01-01

Video encoding for multimedia services over communication networks has significantly advanced in recent years with the development of the highly efficient and flexible H.264/AVC video coding standard and its SVC extension. The emerging H.265/HEVC video coding standard as well as 3D video coding further advance video coding for multimedia communications. This paper first gives an overview of these new video coding standards and then examines their implications for multimedia communications by studying the traffic characteristics of long videos encoded with the new coding standards. We review video coding advances from MPEG-2 and MPEG-4 Part 2 to H.264/AVC and its SVC and MVC extensions as well as H.265/HEVC. For single-layer (nonscalable) video, we compare H.265/HEVC and H.264/AVC in terms of video traffic and statistical multiplexing characteristics. Our study is the first to examine the H.265/HEVC traffic variability for long videos. We also illustrate the video traffic characteristics and statistical multiplexing of scalable video encoded with the SVC extension of H.264/AVC as well as 3D video encoded with the MVC extension of H.264/AVC.

Video Traffic Characteristics of Modern Encoding Standards: H.264/AVC with SVC and MVC Extensions and H.265/HEVC

PubMed Central

2014-01-01

Video encoding for multimedia services over communication networks has significantly advanced in recent years with the development of the highly efficient and flexible H.264/AVC video coding standard and its SVC extension. The emerging H.265/HEVC video coding standard as well as 3D video coding further advance video coding for multimedia communications. This paper first gives an overview of these new video coding standards and then examines their implications for multimedia communications by studying the traffic characteristics of long videos encoded with the new coding standards. We review video coding advances from MPEG-2 and MPEG-4 Part 2 to H.264/AVC and its SVC and MVC extensions as well as H.265/HEVC. For single-layer (nonscalable) video, we compare H.265/HEVC and H.264/AVC in terms of video traffic and statistical multiplexing characteristics. Our study is the first to examine the H.265/HEVC traffic variability for long videos. We also illustrate the video traffic characteristics and statistical multiplexing of scalable video encoded with the SVC extension of H.264/AVC as well as 3D video encoded with the MVC extension of H.264/AVC. PMID:24701145

40 CFR 265.1055 - Standards: Sampling connection systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... with the requirements of § 265.1060 of this subpart. (c) In-situ sampling systems and sampling systems... required in paragraph (a) of this section shall: (1) Return the purged process fluid directly to the...

40 CFR 265.1055 - Standards: Sampling connection systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... with the requirements of § 265.1060 of this subpart. (c) In-situ sampling systems and sampling systems... required in paragraph (a) of this section shall: (1) Return the purged process fluid directly to the...

40 CFR 265.1055 - Standards: Sampling connection systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... with the requirements of § 265.1060 of this subpart. (c) In-situ sampling systems and sampling systems... required in paragraph (a) of this section shall: (1) Return the purged process fluid directly to the...

40 CFR 265.1202 - Closure and post-closure care.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., STORAGE, AND DISPOSAL FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1202 Closure and... as long as it remains in service as a munitions or explosives magazine or storage unit. (b) If, after...

40 CFR 265.1202 - Closure and post-closure care.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., STORAGE, AND DISPOSAL FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1202 Closure and... as long as it remains in service as a munitions or explosives magazine or storage unit. (b) If, after...

40 CFR 265.1202 - Closure and post-closure care.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., STORAGE, AND DISPOSAL FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1202 Closure and... as long as it remains in service as a munitions or explosives magazine or storage unit. (b) If, after...

40 CFR 265.1202 - Closure and post-closure care.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., STORAGE, AND DISPOSAL FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1202 Closure and... as long as it remains in service as a munitions or explosives magazine or storage unit. (b) If, after...

RCRA, superfund and EPCRA hotline training module. Introduction to: Miscellaneous and other units (40 cfr part 264, subpart x and 40 cfr part 265, subparts p, q, and r) updated July 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-07-01

The module describes the basic requirements and types of units of 40 CFR Part 264, Subpart X and standards for broadly defined treatment processes - Thermal treatment (Part 265, Subpart P); chemical, physical, and biological treatment (Subpart Q); and underground injection (Subpart R). Explains when corrective action applies to these subparts. It presents the relationship between Part 264, Subpart X, and Part 265, Subparts P, Q, and R.

A Transmembrane Amino Acid in the GABAA Receptor β2 Subunit Critical for the Actions of Alcohols and Anesthetics

PubMed Central

McCracken, Mandy L.; Borghese, Cecilia M.; Trudell, James R.

2010-01-01

Alcohols and inhaled anesthetics enhance the function of GABAA receptors containing α, β, and γ subunits. Molecular analysis has focused on the role of the α subunits; however, there is evidence that the β subunits may also be important. The goal of our study was to determine whether Asn265, which is homologous to the site implicated in the α subunit (Ser270), contributes to an alcohol and volatile anesthetic binding site in the GABAA receptor β2 subunit. We substituted cysteine for Asn265 and exposed the mutant to the sulfhydryl-specific reagent octyl methanethiosulfonate (OMTS). We used two-electrode voltage-clamp electrophysiology in Xenopus laevis oocytes and found that, after OMTS application, GABA-induced currents were irreversibly potentiated in mutant α1β2(N265C)γ2S receptors [but not α1β2(I264C)γ2S], presumably because of the covalent linking of octanethiol to the thiol group in the substituted cysteine. It is noteworthy that this effect was blocked when OMTS was applied in the presence of octanol. We found that potentiation by butanol, octanol, or isoflurane in the N265C mutant was nearly abolished after the application of OMTS, suggesting that an alcohol and volatile anesthetic binding site at position 265 of the β2 subunit was irreversibly occupied by octanethiol and consequently prevented butanol or isoflurane from binding and producing their effects. OMTS did not affect modulation or direct activation by pentobarbital, but there was a partial reduction of allosteric modulation by flunitrazepam and alphaxalone in mutant α1β2(N265C)γ2S receptors after OMTS was applied. Our findings provide evidence that Asn265 may contribute to an alcohol and anesthetic binding site. PMID:20826568

Highly sensitive MYD88L265P mutation detection by droplet digital PCR in Waldenström Macroglobulinemia.

PubMed

Drandi, Daniela; Genuardi, Elisa; Dogliotti, Irene; Ferrante, Martina; Jiménez, Cristina; Guerrini, Francesca; Lo Schirico, Mariella; Mantoan, Barbara; Muccio, Vittorio; Lia, Giuseppe; Zaccaria, Gian Maria; Omedè, Paola; Passera, Roberto; Orsucci, Lorella; Benevolo, Giulia; Cavallo, Federica; Galimberti, Sara; García-Sanz, Ramón; Boccadoro, Mario; Ladetto, Marco; Ferrero, Simone

2018-03-22

We here describe a novel method for MYD88 L265P mutation detection and minimal residual disease monitoring in Waldenström Macroglobulinemia, by droplet digital PCR, in bone marrow and peripheral blood cells, as well as in circulating cell free DNA. Our method shows a sensitivity of 5.00E-05, by far superior to the widely used allele-specific polymerase chain reaction (1.00E-03). Overall, 291 unsorted samples from 148 patients (133 Waldenstrom 11 IgG-lymphoplasmacytic lymphoma and 4 IgM-monoclonal gammopathy of undetermined significance), 194 baseline and 97 follow-up, were analyzed. 122/128 (95.3%) bone marrow and 47/66 (71.2%) baseline peripheral blood samples scored positive for MYD88 L265P Moreover, to investigate whether MYD88 L265P by droplet digital PCR could be used for minimal residual disease monitoring, mutation levels were compared with IGH-based minimal residual disease analysis in 10 patients, showing to be as informative as to the classical, standardized but not yet validated in Waldenström Macroglobulinemia, IGH-based minimal residual disease assay (r 2 =0.64). Finally, MYD88 L265P detection performed by droplet digital PCR on plasmatic circulating tumor DNA from 60 patients showed a good correlation with bone marrow (bone marrow median mutational value 1.92E-02, plasmatic circulating tumor DNA value: 1.4E-02, peripheral blood value: 1.03E-03). This study indicates that droplet digital PCR MYD88 L265P assay is a feasible and sensitive tool for mutational screening and minimal residual disease monitoring in Waldenström Macroglobulinemia. Both unsorted bone marrow and peripheral blood samples can be reliably tested, as well as circulating tumor DNA, that represents an attractive, less invasive alternative to bone marrow for MYD88 L265P detection. Copyright © 2018, Ferrata Storti Foundation.

MyD88 Mutation in Elderly Predicts Poor Prognosis in Primary Central Nervous System Lymphoma: Multi-Institutional Analysis.

PubMed

Takano, Shingo; Hattori, Keiichiro; Ishikawa, Eiichi; Narita, Yoshitaka; Iwadate, Yasuo; Yamaguchi, Fumio; Nagane, Motoo; Akimoto, Jiro; Oka, Hidehiro; Tanaka, Satoshi; Sakata, Mamiko; Matsuda, Masahide; Yamamoto, Tetsuya; Chiba, Shigeru; Matsumura, Akira

2018-04-01

Recent genetic analysis of primary central nervous system lymphoma (PCNSL) showed that the MyD88 L265P mutation, which is related to NF-κB signaling, was a genetic hallmark for PCNSL; thus it could serve as a genetic marker for diagnosis and a potential target for molecular therapy. However, the role of the MyD88 mutation in PCNSL has not been defined. In this study, we investigated the role of the MyD88 mutation and clinical features of PCNSL-treated patients at several institutions to determine its significance as a prognostic factor. Forty-one PCNSL (diffuse large B-cell type) patients from 8 institutions were included in this study. Their median age was 68 years; median follow-up was 26.7 months; median overall survival was 26.7 months; and their 1-year, 3-year, and 5-year survival rates were 75.6%, 58.5%, and 43.9%, respectively. Deoxyribonucleic acid was extracted from frozen tissue, and the MyD88 L265P mutation was evaluated by polymerase chain reaction and direct sequencing. The MyD88 L265P mutation was found in 61.0% (25/41) of cases. Kaplan-Meier analysis revealed that neither MyD88 L265P mutation nor age >65 years alone significantly predicted overall survival relative to MyD88 wild type and age <65. The MyD88 L265P mutation was predominantly present in patients aged >65 years. Among age >65 patients, the MyD88 L265P mutation portended a worse overall survival compared with the MyD88 wild type (11.5 vs. 56.2 months P < 0.04). The MyD88 L265P mutation predicted a poor prognosis in elderly PCNSL patients. A new tailor-made treatment strategy might be needed for these patients. Copyright © 2017. Published by Elsevier Inc.

40 CFR 265.260 - Monitoring and inspection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... a leak detection system under § 265.254 must record the amount of liquids removed from each leak detection system sump at least once each week during the active life and closure -period. [57 FR 3494, Jan...

Performance evaluation of the intra compression in the video coding standards

NASA Astrophysics Data System (ADS)

Abramowski, Andrzej

2015-09-01

The article presents a comparison of the Intra prediction algorithms in the current state-of-the-art video coding standards, including MJPEG 2000, VP8, VP9, H.264/AVC and H.265/HEVC. The effectiveness of techniques employed by each standard is evaluated in terms of compression efficiency and average encoding time. The compression efficiency is measured using BD-PSNR and BD-RATE metrics with H.265/HEVC results as an anchor. Tests are performed on a set of video sequences, composed of sequences gathered by Joint Collaborative Team on Video Coding during the development of the H.265/HEVC standard and 4K sequences provided by Ultra Video Group. According to results, H.265/HEVC provides significant bit-rate savings at the expense of computational complexity, while VP9 may be regarded as a compromise between the efficiency and required encoding time.

40 CFR 265.110 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Closure... through 265.115 (which concern closure) apply to the owners and operators of all hazardous waste...

40 CFR 265.444 - Inspections.

Code of Federal Regulations, 2013 CFR

2013-07-01

... § 265.444 Inspections. (a) During construction or installation, liners and cover systems (e.g., membranes, sheets, or coatings) must be inspected for uniformity, damage and imperfections (e.g., holes, cracks, thin spots, or foreign materials). Immediately after construction or installation, liners must be...

40 CFR 265.444 - Inspections.

Code of Federal Regulations, 2012 CFR

2012-07-01

... § 265.444 Inspections. (a) During construction or installation, liners and cover systems (e.g., membranes, sheets, or coatings) must be inspected for uniformity, damage and imperfections (e.g., holes, cracks, thin spots, or foreign materials). Immediately after construction or installation, liners must be...

40 CFR 265.444 - Inspections.

Code of Federal Regulations, 2014 CFR

2014-07-01

... § 265.444 Inspections. (a) During construction or installation, liners and cover systems (e.g., membranes, sheets, or coatings) must be inspected for uniformity, damage and imperfections (e.g., holes, cracks, thin spots, or foreign materials). Immediately after construction or installation, liners must be...

40 CFR 265.444 - Inspections.

Code of Federal Regulations, 2011 CFR

2011-07-01

... § 265.444 Inspections. (a) During construction or installation, liners and cover systems (e.g., membranes, sheets, or coatings) must be inspected for uniformity, damage and imperfections (e.g., holes, cracks, thin spots, or foreign materials). Immediately after construction or installation, liners must be...

40 CFR 265.111 - Closure performance standard.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 265.111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...) Controls, minimizes or eliminates, to the extent necessary to protect human health and the environment...

40 CFR 265.111 - Closure performance standard.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 265.111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...) Controls, minimizes or eliminates, to the extent necessary to protect human health and the environment...

40 CFR 265.1 - Purpose, scope, and applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

....1 Section 265.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... establish minimum national standards that define the acceptable management of hazardous waste during the...

40 CFR 265.223 - Containment system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 265.223 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL..., such as grass, shale, or rock, to minimize wind and water erosion and to preserve their structural...

40 CFR 265.72 - Manifest discrepancies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 265.72 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL... waste solvent substituted for waste acid, or toxic constituents not reported on the manifest or shipping...

40 CFR 265.72 - Manifest discrepancies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 265.72 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL... waste solvent substituted for waste acid, or toxic constituents not reported on the manifest or shipping...

40 CFR 265.72 - Manifest discrepancies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 265.72 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL... waste solvent substituted for waste acid, or toxic constituents not reported on the manifest or shipping...

40 CFR 265.340 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES... hazardous waste incinerators (as defined in § 260.10 of this chapter), except as § 265.1 provides otherwise...

40 CFR 265.340 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES... hazardous waste incinerators (as defined in § 260.10 of this chapter), except as § 265.1 provides otherwise...

42 CFR 2.65 - Procedures and criteria for orders authorizing disclosure and use of records to criminally...

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.65..., rape, kidnapping, armed robbery, assault with a deadly weapon, and child abuse and neglect. (2) There...

42 CFR 2.65 - Procedures and criteria for orders authorizing disclosure and use of records to criminally...

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.65..., rape, kidnapping, armed robbery, assault with a deadly weapon, and child abuse and neglect. (2) There...

42 CFR 2.65 - Procedures and criteria for orders authorizing disclosure and use of records to criminally...

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.65..., rape, kidnapping, armed robbery, assault with a deadly weapon, and child abuse and neglect. (2) There...

42 CFR 2.65 - Procedures and criteria for orders authorizing disclosure and use of records to criminally...

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.65..., rape, kidnapping, armed robbery, assault with a deadly weapon, and child abuse and neglect. (2) There...

42 CFR 2.65 - Procedures and criteria for orders authorizing disclosure and use of records to criminally...

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Court Orders Authorizing Disclosure and Use § 2.65..., rape, kidnapping, armed robbery, assault with a deadly weapon, and child abuse and neglect. (2) There...

41 CFR 102-38.265 - Must we keep records on administrative determinations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL PROPERTY Bids Mistakes in Bids § 102-38.265 Must we keep records on administrative... you file with the Comptroller General when requested. ...

41 CFR 102-38.265 - Must we keep records on administrative determinations?

Code of Federal Regulations, 2011 CFR

2011-01-01

... Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL PROPERTY Bids Mistakes in Bids § 102-38.265 Must we keep records on administrative... you file with the Comptroller General when requested. ...

40 CFR 265.54 - Amendment of contingency plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 265.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND..., explosions, or releases of hazardous waste or hazardous waste constituents, or changes the response necessary...

40 CFR 265.228 - Closure and post-closure care.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 265.228 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... or operator must: (1) Remove or decontaminate all waste residues, contaminated containment system...

40 CFR 265.54 - Amendment of contingency plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 265.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND..., explosions, or releases of hazardous waste or hazardous waste constituents, or changes the response necessary...

40 CFR 265.55 - Emergency coordinator.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FACILITIES Contingency Plan and Emergency Procedures § 265.55 Emergency coordinator. At all times, there must... aspects of the facility's contingency plan, all operations and activities at the facility, the location... out the contingency plan. [Comment: The emergency coordinator's responsibilities are more fully...

38 CFR 26.5 - Responsibiities.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) ENVIRONMENTAL EFFECTS OF THE DEPARTMENT OF VETERANS AFFAIRS (VA) ACTIONS § 26.5 Responsibiities. (a) The Director of the Office of Environmental Affairs shall: (1) Be responsible to coordinate and provide guidance to VA elements on all environmental matters; (2) Assist in the preparation of environmental...

40 CFR 265.1 - Purpose, scope, and applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... waste is necessary to protect human health or the environment, that official or specialist may authorize....1 Section 265.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.1 - Purpose, scope, and applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... waste is necessary to protect human health or the environment, that official or specialist may authorize....1 Section 265.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.1 - Purpose, scope, and applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... waste is necessary to protect human health or the environment, that official or specialist may authorize....1 Section 265.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.90 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... from the facility via the uppermost aquifer to water supply wells (domestic, industrial, or.... This demonstration must be certified by a qualified geologist or geotechnical engineer and must... geologist or geotechnical engineer, which satisfies the requirements of § 265.93(d)(3), for an alternate...

40 CFR 265.90 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... from the facility via the uppermost aquifer to water supply wells (domestic, industrial, or.... This demonstration must be certified by a qualified geologist or geotechnical engineer and must... geologist or geotechnical engineer, which satisfies the requirements of § 265.93(d)(3), for an alternate...

40 CFR 265.142 - Cost estimate for closure.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 265.142 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... salvage value that may be realized with the sale of hazardous wastes, or non-hazardous wastes if...

40 CFR 265.142 - Cost estimate for closure.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 265.142 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... salvage value that may be realized with the sale of hazardous wastes, or non-hazardous wastes if...

40 CFR 265.142 - Cost estimate for closure.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 265.142 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... salvage value that may be realized with the sale of hazardous wastes, or non-hazardous wastes if...

40 CFR 265.113 - Closure; time allowed for closure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... includes an amended waste analysis plan, ground-water monitoring and response program, human exposure....113 Section 265.113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND...

40 CFR 265.110 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Closure... the owners and operators of: (1) All hazardous waste disposal facilities; (2) Waste piles and surface... through 265.115 (which concern closure) apply to the owners and operators of all hazardous waste...

40 CFR 265.1059 - Standards: Delay of repair.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 265.1059 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... technically infeasible without a hazardous waste management unit shutdown. In such a case, repair of this...

Comparison of UV-LED and low pressure UV for water disinfection: Photoreactivation and dark repair of Escherichia coli.

PubMed

Li, Guo-Qiang; Wang, Wen-Long; Huo, Zheng-Yang; Lu, Yun; Hu, Hong-Ying

2017-12-01

Studies on ultraviolet light-emitting diode (UV-LED) water disinfection have shown advantages, such as safety, flexible design, and lower starting voltages. However, information about reactivation after UV-LED disinfection is limited, which is an important issue of UV light-based technology. In this study, the photoreactivation and dark repair of Escherichia coli after UV-LEDs and low pressure (LP) UV disinfection were compared. Four UV-LED units, 265 nm, 280 nm, the combination of 265 + 280 (50%), and 265 + 280 (75%) were tested. 265 nm LEDs was more effective than 280 nm LEDs and LP UV lamps for E. coli inactivation. No synergic effect for disinfection was observed from the combination of 265 and 280 nm LEDs. 265 nm LEDs had no different reactivation performances with that of LP UV, while 280 nm LEDs could significantly repress photoreactivation and dark repair at a low irradiation intensity of 6.9 mJ/cm 2 . Furthermore, the UV-induced damage of 280 nm LEDs was less repaired which was determined by endonuclease sensitive site (ESS) assay. The impaired protein activities by 280 nm LEDs might be one of the reasons that inhibited reactivation. A new reactivation rate constant, K max , was introduced into the logistic model to simulate the reactivation data, which showed positive relationship with the maximum survival ratio and was more reasonable to interpret the results of photoreactivation and dark repair. This study revealed the distinct roles of different UV lights in disinfection and reactivation, which is helpful for the future design of UV-LED equipment. Copyright © 2017 Elsevier Ltd. All rights reserved.

Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma.

PubMed

Hattori, Keiichiro; Sakata-Yanagimoto, Mamiko; Suehara, Yasuhito; Yokoyama, Yasuhisa; Kato, Takayasu; Kurita, Naoki; Nishikii, Hidekazu; Obara, Naoshi; Takano, Shingo; Ishikawa, Eiichi; Matsumura, Akira; Hasegawa, Yuichi; Chiba, Shigeru

2018-01-01

Recent sequencing studies demonstrated the MYD88 L265P mutation in more than 70% of primary central nervous system lymphomas (PCNSL), and the clinical significance of this mutation has been proposed as diagnostic and prognostic markers in PCNSL. In contrast, mutational analyses using cell-free DNAs have been reported in a variety of systemic lymphomas. To investigate how sensitively the MYD88 L265P mutation can be identified in cell-free DNA from PCNSL patients, we carried out droplet digital PCR (ddPCR) and targeted deep sequencing (TDS) in 14 consecutive PCNSL patients from whom paired tumor-derived DNA and cell-free DNA was available at diagnosis. The MYD88 L265P mutation was found in tumor-derived DNA from all 14 patients (14/14, 100%). In contrast, among 14 cell-free DNAs evaluated by ddPCR (14/14) and TDS (13/14), the MYD88 L265P mutation was detected in eight out of 14 (ddPCR) and in 0 out of 13 (TDS) samples, implying dependence on the detection method. After chemotherapy, the MYD88 L265P mutation in cell-free DNAs was traced in five patients; unexpectedly, the mutations disappeared after chemotherapy was given, and they remained undetectable in all patients. These observations suggest that ddPCR can sensitively detect the MYD88 L265P mutation in cell-free DNA and could be used as non-invasive diagnostics, but may not be applicable for monitoring minimal residual diseases in PCNSL. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

39 CFR 265.9 - Schedule of fees.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.9... information that will be used for the furtherance of the organization's commercial interests, rather than for... section also apply to information stored within micrographic systems. (c) Four categories of fees to be...

39 CFR 265.6 - Availability of records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265..., 1997, in response to a Freedom of Information Act request, which the Postal Service determines have... the form in which they were originally disclosed, except to the extent that they contain information...

39 CFR 265.6 - Availability of records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265..., 1997, in response to a Freedom of Information Act request, which the Postal Service determines have... the form in which they were originally disclosed, except to the extent that they contain information...

39 CFR 265.9 - Schedule of fees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.9... information that will be used for the furtherance of the organization's commercial interests, rather than for... section also apply to information stored within micrographic systems. (c) Four categories of fees to be...

39 CFR 265.6 - Availability of records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265..., 1997, in response to a Freedom of Information Act request, which the Postal Service determines have... the form in which they were originally disclosed, except to the extent that they contain information...

39 CFR 265.6 - Availability of records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265..., 1997, in response to a Freedom of Information Act request, which the Postal Service determines have... the form in which they were originally disclosed, except to the extent that they contain information...

39 CFR 265.9 - Schedule of fees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.9... information that will be used for the furtherance of the organization's commercial interests, rather than for... section also apply to information stored within micrographic systems. (c) Four categories of fees to be...

39 CFR 265.9 - Schedule of fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.9... information that will be used for the furtherance of the organization's commercial interests, rather than for... section also apply to information stored within micrographic systems. (c) Four categories of fees to be...

40 CFR 265.37 - Arrangements with local authorities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Arrangements with local authorities..., STORAGE, AND DISPOSAL FACILITIES Preparedness and Prevention § 265.37 Arrangements with local authorities... (4) Arrangements to familiarize local hospitals with the properties of hazardous waste handled at the...

40 CFR 265.37 - Arrangements with local authorities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Arrangements with local authorities..., STORAGE, AND DISPOSAL FACILITIES Preparedness and Prevention § 265.37 Arrangements with local authorities... (4) Arrangements to familiarize local hospitals with the properties of hazardous waste handled at the...

40 CFR 265.1201 - Design and operating standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... be stored in accordance with a Standard Operating Procedure specifying procedures to ensure safety... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Design and operating standards. 265... operating standards. (a) Hazardous waste munitions and explosives storage units must be designed and...

40 CFR 265.1201 - Design and operating standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... be stored in accordance with a Standard Operating Procedure specifying procedures to ensure safety... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Design and operating standards. 265... operating standards. (a) Hazardous waste munitions and explosives storage units must be designed and...

40 CFR 265.1201 - Design and operating standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... be stored in accordance with a Standard Operating Procedure specifying procedures to ensure safety... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Design and operating standards. 265... operating standards. (a) Hazardous waste munitions and explosives storage units must be designed and...

40 CFR 265.1201 - Design and operating standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... be stored in accordance with a Standard Operating Procedure specifying procedures to ensure safety... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Design and operating standards. 265... operating standards. (a) Hazardous waste munitions and explosives storage units must be designed and...

Evaluation of median barrier safety issues.

DOT National Transportation Integrated Search

2008-01-01

The objective of this study was to evaluate the effectiveness of the Brifen TL-4 and Trinity CASS median cable barrier systems in preventing cross-median collisions on sections of I-64, I-71, and I-265 (Brifen system) and I-265 (Trinity system) in Je...

33 CFR 104.265 - Security measures for access control.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Security measures for access... SECURITY MARITIME SECURITY MARITIME SECURITY: VESSELS Vessel Security Requirements § 104.265 Security... security measures to: (1) Deter the unauthorized introduction of dangerous substances and devices...

40 CFR 265.1089 - Inspection and monitoring requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Inspection and monitoring requirements..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1089 Inspection and monitoring requirements. (a) The owner or operator shall inspect and monitor...

40 CFR 265.1089 - Inspection and monitoring requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Inspection and monitoring requirements..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1089 Inspection and monitoring requirements. (a) The owner or operator shall inspect and monitor...

40 CFR 265.1089 - Inspection and monitoring requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Inspection and monitoring requirements..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1089 Inspection and monitoring requirements. (a) The owner or operator shall inspect and monitor...

40 CFR 265.1089 - Inspection and monitoring requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Inspection and monitoring requirements..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1089 Inspection and monitoring requirements. (a) The owner or operator shall inspect and monitor...

40 CFR 265.1089 - Inspection and monitoring requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Inspection and monitoring requirements..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Tanks, Surface Impoundments, and Containers § 265.1089 Inspection and monitoring requirements. (a) The owner or operator shall inspect and monitor...

Multiple Model Demand Forecasting Compared to Air Force Logistics Command D062 Performance.

DTIC Science & Technology

1980-06-01

SRI" 1002. 930. 53.4. 46 . 074 . 119. 01. 93. 249. 224.4 METHOD $1L 4 1 2 6 4 3 2 5 FOCUS FOIC 860. 262 . 049. 9133. 966. 931. 6?. 498. 662. 21.2 -13.9...5001. 5124. 426. 1192.0 150.0 SMITH II 4018. 4640 . 3620. 9650. 9587. 8582. 965. 3937. 2468. 2486.7 2363.7 TREND 3786. 3842. 1584. 2760. 4518. 4638...FORECASTS BASD( UPON IDENTICAL DEMND DATA TEM I 30 QUARTER 2 3 4 5 6 7 0 9 RAN DIAS ACT DEMAND 262 . 269. 265. 250. 259. 262 . 265. 265. 262 . FORECAST

RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: Treatment, storage, and disposal facilities (40 CFR parts 264/265, subparts A-E) updated as of July 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-11-01

The module presents an overview of the general treatment, storage, and disposal facility (TSDF) standards found in 40 CFR parts 264/265, subparts A through E. It identifies and explains each exclusion from parts 264/265, and provides definitions of excluded units, such as wastewater treatment unit and elementary neutralization unit. It locates and describes the requirements for waste analysis and personnel training. It also describes the purpose of a contingency plan and lists the emergency notification procedures. It describes manifest procedures and responsibilities, and lists the unmanifested waste reporting requirements.

40 CFR 265.1055 - Standards: Sampling connection systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Standards: Sampling connection systems..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Equipment Leaks § 265.1055 Standards: Sampling connection systems. (a) Each sampling connection system shall be equipped with a closed-purge, closed-loop...

40 CFR 265.1055 - Standards: Sampling connection systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Standards: Sampling connection systems..., STORAGE, AND DISPOSAL FACILITIES Air Emission Standards for Equipment Leaks § 265.1055 Standards: Sampling connection systems. (a) Each sampling connection system shall be equipped with a closed-purge, closed-loop...

39 CFR 265.13 - Compliance with subpoenas, summonses, and court orders by postal employees within the Inspection...

Code of Federal Regulations, 2011 CFR

2011-07-01

... SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.13 Compliance with subpoenas..., statistical or information accumulations, records of meetings and conversations, film impressions, magnetic... have access to Inspection Service information and records. (6) Inspection Service means the...

39 CFR 265.13 - Compliance with subpoenas, summonses, and court orders by postal employees within the Inspection...

Code of Federal Regulations, 2014 CFR

2014-07-01

... SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.13 Compliance with subpoenas..., statistical or information accumulations, records of meetings and conversations, film impressions, magnetic... have access to Inspection Service information and records. (6) Inspection Service means the...

39 CFR 265.13 - Compliance with subpoenas, summonses, and court orders by postal employees within the Inspection...

Code of Federal Regulations, 2012 CFR

2012-07-01

... SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.13 Compliance with subpoenas..., statistical or information accumulations, records of meetings and conversations, film impressions, magnetic... have access to Inspection Service information and records. (6) Inspection Service means the...

39 CFR 265.13 - Compliance with subpoenas, summonses, and court orders by postal employees within the Inspection...

Code of Federal Regulations, 2013 CFR

2013-07-01

... SERVICE ORGANIZATION AND ADMINISTRATION RELEASE OF INFORMATION § 265.13 Compliance with subpoenas..., statistical or information accumulations, records of meetings and conversations, film impressions, magnetic... have access to Inspection Service information and records. (6) Inspection Service means the...

15 CFR 265.19 - Unattended vehicles.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Unattended vehicles. 265.19 Section... Unattended vehicles. No person shall leave a motor vehicle unattended on the site with the engine running or a key in the ignition switch or the vehicle not effectively braked. ...

15 CFR 265.19 - Unattended vehicles.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Unattended vehicles. 265.19 Section... Unattended vehicles. No person shall leave a motor vehicle unattended on the site with the engine running or a key in the ignition switch or the vehicle not effectively braked. ...