Sample records for bohrium 266

  1. Odd-Z Transactinide Compound Nucleus Reactions Including the Discovery of 260Bh

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, Sarah L.

    Several reactions producing odd-Z transactinide compound nuclei were studiedwith the 88-Inch Cyclotron and the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory. The goal was to produce the same compound nucleus ator near the same excitation energy with similar values of angular momentum via differentnuclear reactions. In doing so, it can be determined if there is a preference in entrancechannel, because under these experimental conditions the survival portion of Swiatecki, Siwek-Wilcznska, and Wilczynski's"Fusion By Diffusion" model is nearly identical forthe two reactions. Additionally, because the same compound nucleus is produced, theexit channel is the same. Four compound nuclei were examined in this study: 258Db, 262Bh, 266Mt, and 272Rg. These nuclei were produced by using very similar heavy-ion induced-fusion reactions which differ only by one proton in the projectile or target nucleus (e.g.: 50Ti + 209Bi vs. 51V + 208Pb). Peak 1n exit channel cross sections were determined for each reaction in each pair, and three of the four pairs' cross sections were identical within statistical uncertainties. This indicates there is not an obvious preference of entrancechannel in these paired reactions. Charge equilibration immediately prior to fusionleading to a decreased fusion barrier is the likely cause of this phenomenon. In addition to this systematic study, the lightest isotope of element 107, bohrium, was discovered in the 209Bi( 52Cr,n) reaction. 260Bh was found to decay by emission of a 10.16 MeV alpha particle with a half-life of 35more » $$+19\\atop{-9}$$ ms. The cross section is 59 pb at an excitation energy of 15.0 MeV. The effect of the N = 152 shell is also seen in this isotope's alpha particle energy, the first evidence of such an effect in Bh. All reactions studied are also compared to model predictions by Swiatecki, Siwek-Wilcznska, and Wilczynski 's" Fusion By Diffusion " theory.« less

  2. Road dust and its effect on human health: a literature review

    PubMed Central

    2018-01-01

    The purpose of this study was to determine the effects of road dust on human health. A PubMed search was used to extract references that included the words “road dust” and “health” or “fugitive dust” and “health” in the title or abstract. A total of 46 references were extracted and selected for review after the primary screening of 949 articles. The respiratory system was found to be the most affected system in the human body. Lead, platinum-group elements (platinum, rhodium, and bohrium), aluminum, zinc, vanadium, and polycyclic aromatic hydrocarbons were the components of road dust that were most frequently referenced in the articles reviewed. Road dust was found to have harmful effects on the human body, especially on the respiratory system. To determine the complex mechanism of action of various components of road dust on the human body and the results thereof, the authors recommend a further meta-analysis and extensive risk-assessment research into the health impacts of dust exposure. PMID:29642653

  3. Overexpression of a Domain of Unknown Function 266-containing protein results in high cellulose content, reduced recalcitrance, and enhanced plant growth in the bioenergy crop Populus.

    PubMed

    Yang, Yongil; Yoo, Chang Geun; Guo, Hao-Bo; Rottmann, William; Winkeler, Kimberly A; Collins, Cassandra M; Gunter, Lee E; Jawdy, Sara S; Yang, Xiaohan; Guo, Hong; Pu, Yunqiao; Ragauskas, Arthur J; Tuskan, Gerald A; Chen, Jin-Gui

    2017-01-01

    Domain of Unknown Function 266 (DUF266) is a plant-specific domain. DUF266-containing proteins (DUF266 proteins) have been categorized as 'not classified glycosyltransferases (GTnc)' due to amino acid similarity with GTs. However, little is known about the function of DUF266 proteins. Phylogenetic analysis revealed that DUF266 proteins are only present in the land plants including moss and lycophyte. We report the functional characterization of one member of DUF266 proteins in Populus, PdDUF266A. PdDUF266A was ubiquitously expressed with high abundance in the xylem. In Populus transgenic plants overexpressing PdDUF266A ( OXPdDUF266A ), the glucose and cellulose contents were significantly higher, while the lignin content was lower than that in the wild type. Degree of polymerization of cellulose in OXPdDUF266A transgenic plants was also higher, whereas cellulose crystallinity index remained unchanged. Gene expression analysis indicated that cellulose biosynthesis-related genes such as CESA and SUSY were upregulated in mature leaf and xylem of OXPdDUF266A transgenic plants. Moreover, PdDUF266A overexpression resulted in an increase of biomass production. Their glucose contents and biomass phenotypes were further validated via heterologous expression of PdDUF266A in Arabidopsis. Results from saccharification treatment demonstrated that the rate of sugar release was increased by approximately 38% in the OXPdDUF266A transgenic plants. These results suggest that the overexpression of PdDUF266A can increase cellulose content, reduce recalcitrance, and enhance biomass production, and that PdDUF266A is a promising target for genetic manipulation for biofuel production.

  4. Overexpression of a domain of unknown function 266-containing protein results in high cellulose content, reduced recalcitrance, and enhanced plant growth in the bioenergy crop Populus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Yongil; Yoo, Chang Geun; Guo, Hao -Bo

    Domain of Unknown Function 266 (DUF266) is a plant-specific domain. DUF266-containing proteins (DUF266 proteins) have been categorized as ‘not classified glycosyltransferases (GTnc)’ due to amino acid similarity with GTs. However, little is known about the function of DUF266 proteins. As a result, Phylogenetic analysis revealed that DUF266 proteins are only present in the land plants including moss and lycophyte. We report the functional characterization of one member of DUF266 proteins in Populus, PdDUF266A. PdDUF266A was ubiquitously expressed with high abundance in the xylem. In Populus transgenic plants overexpressing PdDUF266A ( OXPdDUF266A), the glucose and cellulose contents were significantly higher, whilemore » the lignin content was lower than that in the wild type. Degree of polymerization of cellulose in OXPdDUF266A transgenic plants was also higher, whereas cellulose crystallinity index remained unchanged. Gene expression analysis indicated that cellulose biosynthesis-related genes such as CESA and SUSY were upregulated in mature leaf and xylem of OXPdDUF266A transgenic plants. Moreover, PdDUF266A overexpression resulted in an increase of biomass production. Their glucose contents and biomass phenotypes were further validated via heterologous expression of PdDUF266A in Arabidopsis. Results from saccharification treatment demonstrated that the rate of sugar release was increased by approximately 38% in the OXPdDUF266A transgenic plants.« less

  5. Overexpression of a domain of unknown function 266-containing protein results in high cellulose content, reduced recalcitrance, and enhanced plant growth in the bioenergy crop Populus

    DOE PAGES

    Yang, Yongil; Yoo, Chang Geun; Guo, Hao -Bo; ...

    2017-03-23

    Domain of Unknown Function 266 (DUF266) is a plant-specific domain. DUF266-containing proteins (DUF266 proteins) have been categorized as ‘not classified glycosyltransferases (GTnc)’ due to amino acid similarity with GTs. However, little is known about the function of DUF266 proteins. As a result, Phylogenetic analysis revealed that DUF266 proteins are only present in the land plants including moss and lycophyte. We report the functional characterization of one member of DUF266 proteins in Populus, PdDUF266A. PdDUF266A was ubiquitously expressed with high abundance in the xylem. In Populus transgenic plants overexpressing PdDUF266A ( OXPdDUF266A), the glucose and cellulose contents were significantly higher, whilemore » the lignin content was lower than that in the wild type. Degree of polymerization of cellulose in OXPdDUF266A transgenic plants was also higher, whereas cellulose crystallinity index remained unchanged. Gene expression analysis indicated that cellulose biosynthesis-related genes such as CESA and SUSY were upregulated in mature leaf and xylem of OXPdDUF266A transgenic plants. Moreover, PdDUF266A overexpression resulted in an increase of biomass production. Their glucose contents and biomass phenotypes were further validated via heterologous expression of PdDUF266A in Arabidopsis. Results from saccharification treatment demonstrated that the rate of sugar release was increased by approximately 38% in the OXPdDUF266A transgenic plants.« less

  6. Comparative Effect of an Addition of a Surface Term to Woods-Saxon Potential on Thermodynamics of a Nucleon

    NASA Astrophysics Data System (ADS)

    Lütfüoğlu, B. C.

    2018-01-01

    In this study, we reveal the difference between Woods-Saxon (WS) and Generalized Symmetric Woods-Saxon (GSWS) potentials in order to describe the physical properties of a nucleon, by means of solving Schrödinger equation for the two potentials. The additional term squeezes the WS potential well, which leads an upward shift in the spectrum, resulting in a more realistic picture. The resulting GSWS potential does not merely accommodate extra quasi bound states, but also has modified bound state spectrum. As an application, we apply the formalism to a real problem, an α particle confined in Bohrium-270 nucleus. The thermodynamic functions Helmholtz energy, entropy, internal energy, specific heat of the system are calculated and compared for both wells. The internal energy and the specific heat capacity increase as a result of upward shift in the spectrum. The shift of the Helmholtz free energy is a direct consequence of the shift of the spectrum. The entropy decreases because of a decrement in the number of available states. Supported by the Turkish Science and Research Council (TÜBİTAK) and Akdeniz University

  7. 49 CFR 266.7 - Project eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Project eligibility. 266.7 Section 266.7... TRANSPORTATION ACT § 266.7 Project eligibility. (a) Rail service continuation assistance, acquisition assistance and substitute service assistance. A project is eligible for assistance under § 266.3(a) (1), (2), and...

  8. 49 CFR 266.7 - Project eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Project eligibility. 266.7 Section 266.7... TRANSPORTATION ACT § 266.7 Project eligibility. (a) Rail service continuation assistance, acquisition assistance and substitute service assistance. A project is eligible for assistance under § 266.3(a) (1), (2), and...

  9. 49 CFR 266.7 - Project eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Project eligibility. 266.7 Section 266.7... TRANSPORTATION ACT § 266.7 Project eligibility. (a) Rail service continuation assistance, acquisition assistance and substitute service assistance. A project is eligible for assistance under § 266.3(a) (1), (2), and...

  10. 49 CFR 266.7 - Project eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Project eligibility. 266.7 Section 266.7... TRANSPORTATION ACT § 266.7 Project eligibility. (a) Rail service continuation assistance, acquisition assistance and substitute service assistance. A project is eligible for assistance under § 266.3(a) (1), (2), and...

  11. 49 CFR 266.7 - Project eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Project eligibility. 266.7 Section 266.7... TRANSPORTATION ACT § 266.7 Project eligibility. (a) Rail service continuation assistance, acquisition assistance and substitute service assistance. A project is eligible for assistance under § 266.3(a) (1), (2), and...

  12. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Construction records. 195.266 Section 195.266 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.266 Construction records. A complete record that shows the following must be...

  13. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Construction records. 195.266 Section 195.266 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.266 Construction records. A complete record that shows the following must be...

  14. 24 CFR 266.210 - HUD-retained review functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false HUD-retained review functions. 266.210 Section 266.210 Housing and Urban Development Regulations Relating to Housing and Urban... Program Requirements § 266.210 HUD-retained review functions. Certain functions are retained by the...

  15. 40 CFR 266.205 - Standards applicable to the storage of solid waste military munitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... solid waste military munitions. 266.205 Section 266.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.205 Standards...

  16. 40 CFR 266.205 - Standards applicable to the storage of solid waste military munitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... solid waste military munitions. 266.205 Section 266.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.205 Standards...

  17. 40 CFR 266.205 - Standards applicable to the storage of solid waste military munitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... solid waste military munitions. 266.205 Section 266.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.205 Standards...

  18. 24 CFR 266.610 - Method of payment of mortgage insurance premiums.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... insurance premiums. 266.610 Section 266.610 Housing and Urban Development Regulations Relating to Housing... MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.610 Method of payment of mortgage insurance premiums. In the cases that the Commissioner deems appropriate, the...

  19. 24 CFR 266.610 - Method of payment of mortgage insurance premiums.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... insurance premiums. 266.610 Section 266.610 Housing and Urban Development Regulations Relating to Housing... MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.610 Method of payment of mortgage insurance premiums. In the cases that the Commissioner deems appropriate, the...

  20. 24 CFR 266.636 - Insuring new loans for defaulted projects.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Claim Procedures § 266.636 Insuring new loans for defaulted projects. The... projects. 266.636 Section 266.636 Housing and Urban Development Regulations Relating to Housing and Urban...

  1. 40 CFR 266.202 - Definition of solid waste.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Definition of solid waste. 266.202 Section 266.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not...

  2. 40 CFR 266.202 - Definition of solid waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Definition of solid waste. 266.202 Section 266.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not...

  3. 49 CFR 266.11 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION ACT § 266.11 Allowable costs. Allowable costs include only the following costs which are properly allocable to the work performed: Planning and program operation costs which are allowed under Federal... 49 Transportation 4 2010-10-01 2010-10-01 false Allowable costs. 266.11 Section 266.11...

  4. 27 CFR 26.266 - Tax payment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Tax payment. 26.266 Section 26.266 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Port of Entry From the Virgin Islands § 26.266 Tax payment. The internal revenue tax on liquors (except...

  5. 39 CFR 266.6 - Procedures for requesting inspection, copying, or amendment of records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... amendment of records. 266.6 Section 266.6 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.6 Procedures for requesting inspection, copying, or amendment of... request amendment to personal information within a Privacy Act System of Records. (a) Submission of...

  6. 39 CFR 266.6 - Procedures for requesting inspection, copying, or amendment of records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... amendment of records. 266.6 Section 266.6 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.6 Procedures for requesting inspection, copying, or amendment of... request amendment to personal information within a Privacy Act System of Records. (a) Submission of...

  7. 39 CFR 266.6 - Procedures for requesting inspection, copying, or amendment of records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... amendment of records. 266.6 Section 266.6 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.6 Procedures for requesting inspection, copying, or amendment of... request amendment to personal information within a Privacy Act System of Records. (a) Submission of...

  8. 39 CFR 266.4 - Collection and disclosure of information about individuals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Collection and disclosure of information about individuals. 266.4 Section 266.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.4 Collection and disclosure of information about individuals. (a) The...

  9. 39 CFR 266.7 - Appeal procedure.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Appeal procedure. 266.7 Section 266.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.7 Appeal... the disputed information will be accepted and attached to the relevant personal record. [40 FR 45723...

  10. 39 CFR 266.7 - Appeal procedure.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Appeal procedure. 266.7 Section 266.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.7 Appeal... the disputed information will be accepted and attached to the relevant personal record. [40 FR 45723...

  11. 39 CFR 266.4 - Collection and disclosure of information about individuals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Collection and disclosure of information about individuals. 266.4 Section 266.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.4 Collection and disclosure of information about individuals. (a) The...

  12. 39 CFR 266.4 - Collection and disclosure of information about individuals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Collection and disclosure of information about individuals. 266.4 Section 266.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.4 Collection and disclosure of information about individuals. (a) The...

  13. 39 CFR 266.4 - Collection and disclosure of information about individuals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Collection and disclosure of information about individuals. 266.4 Section 266.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.4 Collection and disclosure of information about individuals. (a) The...

  14. 39 CFR 266.7 - Appeal procedure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Appeal procedure. 266.7 Section 266.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.7 Appeal... the disputed information will be accepted and attached to the relevant personal record. [40 FR 45723...

  15. 39 CFR 266.7 - Appeal procedure.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Appeal procedure. 266.7 Section 266.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.7 Appeal... the disputed information will be accepted and attached to the relevant personal record. [40 FR 45723...

  16. 39 CFR 266.6 - Procedures for requesting inspection, copying, or amendment of records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... amendment of records. 266.6 Section 266.6 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.6 Procedures for requesting inspection, copying, or amendment of... request amendment to personal information within a Privacy Act System of Records. (a) Submission of...

  17. 39 CFR 266.6 - Procedures for requesting inspection, copying, or amendment of records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... amendment of records. 266.6 Section 266.6 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.6 Procedures for requesting inspection, copying, or amendment of... request amendment to personal information within a Privacy Act System of Records. (a) Submission of...

  18. 39 CFR 266.4 - Collection and disclosure of information about individuals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Collection and disclosure of information about individuals. 266.4 Section 266.4 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.4 Collection and disclosure of information about individuals. (a) The...

  19. 39 CFR 266.7 - Appeal procedure.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Appeal procedure. 266.7 Section 266.7 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.7 Appeal... the disputed information will be accepted and attached to the relevant personal record. [40 FR 45723...

  20. 40 CFR Appendix IV to Part 266 - Reference Air Concentrations*

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Reference Air Concentrations* IV Appendix IV to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Pt. 266, App. IV Appendix IV to Part 266—Reference Air Concentrations* Constituent CAS...

  1. 40 CFR Appendix IV to Part 266 - Reference Air Concentrations*

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Reference Air Concentrations* IV Appendix IV to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Pt. 266, App. IV Appendix IV to Part 266—Reference Air Concentrations* Constituent CAS...

  2. 32 CFR 266.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.4 Policy. The DoD Components shall rely on and use financial and performance audits performed by non... 32 National Defense 2 2013-07-01 2013-07-01 false Policy. 266.4 Section 266.4 National Defense...

  3. 32 CFR 266.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.4 Policy. The DoD Components shall rely on and use financial and performance audits performed by non... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 266.4 Section 266.4 National Defense...

  4. 32 CFR 266.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.4 Policy. The DoD Components shall rely on and use financial and performance audits performed by non... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 266.4 Section 266.4 National Defense...

  5. 32 CFR 266.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.4 Policy. The DoD Components shall rely on and use financial and performance audits performed by non... 32 National Defense 2 2012-07-01 2012-07-01 false Policy. 266.4 Section 266.4 National Defense...

  6. 32 CFR 266.4 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.4 Policy. The DoD Components shall rely on and use financial and performance audits performed by non... 32 National Defense 2 2011-07-01 2011-07-01 false Policy. 266.4 Section 266.4 National Defense...

  7. 40 CFR Appendix IV to Part 266 - Reference Air Concentrations*

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Reference Air Concentrations* IV Appendix IV to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Pt. 266, App. IV Appendix IV to Part 266—Reference Air Concentrations* Constituent CAS...

  8. 40 CFR Appendix IV to Part 266 - Reference Air Concentrations*

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Reference Air Concentrations* IV Appendix IV to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Pt. 266, App. IV Appendix IV to Part 266—Reference Air Concentrations* Constituent CAS...

  9. 20 CFR 266.10 - Use of benefit payments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Use of benefit payments. 266.10 Section 266.10 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT REPRESENTATIVE PAYMENT § 266.10 Use of benefit payments. (a) Current maintenance. Payments made to an individual as...

  10. 20 CFR 266.10 - Use of benefit payments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Use of benefit payments. 266.10 Section 266.10 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT REPRESENTATIVE PAYMENT § 266.10 Use of benefit payments. (a) Current maintenance. Payments made to an individual...

  11. 20 CFR 266.10 - Use of benefit payments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Use of benefit payments. 266.10 Section 266.10 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT REPRESENTATIVE PAYMENT § 266.10 Use of benefit payments. (a) Current maintenance. Payments made to an individual...

  12. 24 CFR 266.652 - Determining share of loss.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Determining share of loss. 266.652 Section 266.652 Housing and Urban Development Regulations Relating to Housing and Urban Development... Rights and Obligations Claim Procedures § 266.652 Determining share of loss. The total loss computed in...

  13. 27 CFR 26.266 - Tax payment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Tax payment. 26.266 Section 26.266 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Port of Entry From the Virgin Islands § 26.266 Tax payment. The internal revenue tax on liquors (except...

  14. 24 CFR 266.405 - Title.

    Code of Federal Regulations, 2010 CFR

    2004-04-01

    ... 24 Housing and Urban Development 2 2004-04-01 2004-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title evidence...

  15. 24 CFR 266.405 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-04-01

    ... 24 Housing and Urban Development 2 2005-04-01 2005-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title evidence...

  16. 40 CFR 266.206 - Standards applicable to the treatment and disposal of waste military munitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and disposal of waste military munitions. 266.206 Section 266.206 Protection of Environment... HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.206 Standards applicable to the treatment and disposal of waste military munitions. The treatment and disposal...

  17. 40 CFR 266.206 - Standards applicable to the treatment and disposal of waste military munitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and disposal of waste military munitions. 266.206 Section 266.206 Protection of Environment... HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.206 Standards applicable to the treatment and disposal of waste military munitions. The treatment and disposal...

  18. 40 CFR 266.206 - Standards applicable to the treatment and disposal of waste military munitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and disposal of waste military munitions. 266.206 Section 266.206 Protection of Environment... HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.206 Standards applicable to the treatment and disposal of waste military munitions. The treatment and disposal...

  19. 40 CFR 266.206 - Standards applicable to the treatment and disposal of waste military munitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and disposal of waste military munitions. 266.206 Section 266.206 Protection of Environment... HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.206 Standards applicable to the treatment and disposal of waste military munitions. The treatment and disposal...

  20. 40 CFR 266.206 - Standards applicable to the treatment and disposal of waste military munitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and disposal of waste military munitions. 266.206 Section 266.206 Protection of Environment... HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.206 Standards applicable to the treatment and disposal of waste military munitions. The treatment and disposal...

  1. 38 CFR 17.266 - Copyrights and patents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Copyrights and patents. 17.266 Section 17.266 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants for Exchange of Information § 17.266 Copyrights and patents. If a grant-supported program results...

  2. 38 CFR 17.266 - Copyrights and patents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Copyrights and patents. 17.266 Section 17.266 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants for Exchange of Information § 17.266 Copyrights and patents. If a grant-supported program results...

  3. 38 CFR 17.266 - Copyrights and patents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Copyrights and patents. 17.266 Section 17.266 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants for Exchange of Information § 17.266 Copyrights and patents. If a grant-supported program results...

  4. 38 CFR 17.266 - Copyrights and patents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Copyrights and patents. 17.266 Section 17.266 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants for Exchange of Information § 17.266 Copyrights and patents. If a grant-supported program results...

  5. 38 CFR 17.266 - Copyrights and patents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Copyrights and patents. 17.266 Section 17.266 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants for Exchange of Information § 17.266 Copyrights and patents. If a grant-supported program results...

  6. 40 CFR Appendix Vi to Part 266 - Stack Plume Rise

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Stack Plume Rise VI Appendix VI to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES Pt. 266, App. VI Appendix VI to Part 266—Stack Plume Rise [Estimated Plume Rise (in Meters) Based...

  7. 46 CFR 153.266 - Tank linings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Tank linings. 153.266 Section 153.266 Shipping COAST... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Tanks § 153.266 Tank linings. A tank lining must be: (a) At least as elastic as the tank material; and (b) Applied or...

  8. 46 CFR 153.266 - Tank linings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Tank linings. 153.266 Section 153.266 Shipping COAST... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Tanks § 153.266 Tank linings. A tank lining must be: (a) At least as elastic as the tank material; and (b) Applied or...

  9. 46 CFR 153.266 - Tank linings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Tank linings. 153.266 Section 153.266 Shipping COAST... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Tanks § 153.266 Tank linings. A tank lining must be: (a) At least as elastic as the tank material; and (b) Applied or...

  10. 46 CFR 153.266 - Tank linings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Tank linings. 153.266 Section 153.266 Shipping COAST... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Tanks § 153.266 Tank linings. A tank lining must be: (a) At least as elastic as the tank material; and (b) Applied or...

  11. 46 CFR 153.266 - Tank linings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Tank linings. 153.266 Section 153.266 Shipping COAST... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Tanks § 153.266 Tank linings. A tank lining must be: (a) At least as elastic as the tank material; and (b) Applied or...

  12. 39 CFR 266.8 - Schedule of fees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Schedule of fees. 266.8 Section 266.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.8 Schedule of fees. (a) Policy. The purpose of this section is to establish fair and equitable fees to permit...

  13. 39 CFR 266.8 - Schedule of fees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Schedule of fees. 266.8 Section 266.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.8 Schedule of fees. (a) Policy. The purpose of this section is to establish fair and equitable fees to permit...

  14. 39 CFR 266.8 - Schedule of fees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Schedule of fees. 266.8 Section 266.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.8 Schedule of fees. (a) Policy. The purpose of this section is to establish fair and equitable fees to permit...

  15. 39 CFR 266.8 - Schedule of fees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Schedule of fees. 266.8 Section 266.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.8 Schedule of fees. (a) Policy. The purpose of this section is to establish fair and equitable fees to permit...

  16. 39 CFR 266.8 - Schedule of fees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Schedule of fees. 266.8 Section 266.8 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.8 Schedule of fees. (a) Policy. The purpose of this section is to establish fair and equitable fees to permit...

  17. 12 CFR 26.6 - General exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false General exemption. 26.6 Section 26.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 26.6... minority group, or women; (3) Is a depository institution that has been chartered for less than two years...

  18. 20 CFR 667.266 - What are the limitations related to religious activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... activities? 667.266 Section 667.266 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF..., Costs and Limitations § 667.266 What are the limitations related to religious activities? (a) Limitations related to sectarian activities are set forth at WIA section 188(a)(3) and 29 CFR 37.6(f). (b)(1...

  19. 40 CFR 266.105 - Standards to control particulate matter.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... matter. 266.105 Section 266.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... prescribed in 40 CFR part 60, appendix A, methods 1 through 5, and appendix IX of this part. (b) An owner or operator meeting the requirements of § 266.109(b) for the low risk waste exemption is exempt from the...

  20. 40 CFR Appendix Vi to Part 266 - Stack Plume Rise

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Stack Plume Rise VI Appendix VI to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES Pt. 266, App. VI Appendix VI to Part 266—Stack Plume Rise [Estimated Plume Rise (in Meters) Based...

  1. 42 CFR 412.266 - Availability of wage data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Availability of wage data. 412.266 Section 412.266... Review Board Composition and Procedures § 412.266 Availability of wage data. A hospital may obtain the average hourly wage data necessary to prepare its application to the MGCRB from Federal Register documents...

  2. 29 CFR 1952.266 - Where the plan may be inspected.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and copied during normal business hours at the following locations: Office of State Programs... 29 Labor 9 2010-07-01 2010-07-01 false Where the plan may be inspected. 1952.266 Section 1952.266..., DEPARTMENT OF LABOR (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Michigan § 1952.266...

  3. 20 CFR 667.266 - What are the limitations related to religious activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... activities? 667.266 Section 667.266 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF..., Costs and Limitations § 667.266 What are the limitations related to religious activities? (a) Limitations related to sectarian activities are set forth at WIA section 188(a)(3) and 29 CFR 37.6(f). (b)(1...

  4. 43 CFR 2.66 - What are public liaisons?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false What are public liaisons? 2.66 Section 2.66 Public Lands: Interior Office of the Secretary of the Interior FREEDOM OF INFORMATION ACT; RECORDS AND TESTIMONY General Information § 2.66 What are public liaisons? (a) Each bureau has a FOIA Public...

  5. 20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

  6. 30 CFR 550.266 - After receiving the DPP or DOCD, what will BOEM do?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false After receiving the DPP or DOCD, what will BOEM do? 550.266 Section 550.266 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... Review and Decision Process for the Dpp Or Docd § 550.266 After receiving the DPP or DOCD, what will BOEM...

  7. 30 CFR 250.266 - After receiving the DPP or DOCD, what will MMS do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After receiving the DPP or DOCD, what will MMS do? 250.266 Section 250.266 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Decision Process for the Dpp Or Docd § 250.266 After receiving the DPP or DOCD, what will MMS do? (a...

  8. 30 CFR 550.266 - After receiving the DPP or DOCD, what will BOEM do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false After receiving the DPP or DOCD, what will BOEM do? 550.266 Section 550.266 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... Review and Decision Process for the Dpp Or Docd § 550.266 After receiving the DPP or DOCD, what will BOEM...

  9. 30 CFR 550.266 - After receiving the DPP or DOCD, what will BOEM do?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false After receiving the DPP or DOCD, what will BOEM do? 550.266 Section 550.266 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... Review and Decision Process for the Dpp Or Docd § 550.266 After receiving the DPP or DOCD, what will BOEM...

  10. 20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

  11. 20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

  12. 20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

  13. 20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

  14. 78 FR 4353 - Proposed Amendment of Area Navigation (RNAV) Route T-266; AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ...-1295; Airspace Docket No. 12-AAL-10] RIN 2120-AA66 Proposed Amendment of Area Navigation (RNAV) Route T... (NPRM). SUMMARY: This action proposes to modify low-altitude RNAV route T-266 in the state of Alaska by... Regulations (14 CFR) part 71 to modify RNAV route T-266 in Alaska. T- 266 is currently defined by the Coghland...

  15. 26 CFR 1.266-1 - Taxes and carrying charges chargeable to capital account and treated as capital items.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Taxes and carrying charges chargeable to capital account and treated as capital items. 1.266-1 Section 1.266-1 Internal Revenue INTERNAL REVENUE SERVICE... § 1.266-1 Taxes and carrying charges chargeable to capital account and treated as capital items. (a)(1...

  16. 24 CFR 266.305 - HFAs accepting less than 50 percent of risk.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the performance of all functions except those HUD-retained functions specified in § 266.210 and 266... reviews. The HFA is responsible for inspections during construction, processing and approving advances of...

  17. 40 CFR Appendix X to Part 266 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] X Appendix X to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR... FACILITIES Appendix X to Part 266 [Reserved] ...

  18. 40 CFR Appendix X to Part 266 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] X Appendix X to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR... FACILITIES Appendix X to Part 266 [Reserved] ...

  19. 40 CFR Appendix X to Part 266 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] X Appendix X to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR... FACILITIES Appendix X to Part 266 [Reserved] ...

  20. 40 CFR Appendix X to Part 266 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] X Appendix X to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR... FACILITIES Appendix X to Part 266 [Reserved] ...

  1. 40 CFR Appendix X to Part 266 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] X Appendix X to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR... FACILITIES Appendix X to Part 266 [Reserved] ...

  2. 40 CFR 266.201 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Definitions. 266.201 Section 266.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  3. 40 CFR 98.266 - Data reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... missing data procedures were used to estimate phosphate rock consumption (months) and inorganic carbon... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Data reporting requirements. 98.266... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.266 Data reporting...

  4. 40 CFR 98.266 - Data reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... missing data procedures were used to estimate phosphate rock consumption (months) and inorganic carbon... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Data reporting requirements. 98.266... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.266 Data reporting...

  5. 40 CFR 98.266 - Data reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... missing data procedures were used to estimate phosphate rock consumption (months) and inorganic carbon... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Data reporting requirements. 98.266... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.266 Data reporting...

  6. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Eligible projects. 266.200 Section 266.200 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  7. 40 CFR 98.266 - Data reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... phosphoric acid process lines. (8) Number of times missing data procedures were used to estimate phosphate... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.266... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.266 Data reporting...

  8. 40 CFR 98.266 - Data reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... wet-process phosphoric acid process lines. (8) Number of times missing data procedures were used to... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Data reporting requirements. 98.266... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.266 Data reporting...

  9. 24 CFR 266.612 - Insurance endorsement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance endorsement. 266.612... Rights and Obligations Insurance Endorsement § 266.612 Insurance endorsement. (a) Initial endorsement. The Commissioner shall indicate his or her insurance of the mortgage by endorsing the original credit...

  10. 16 CFR 1500.266 - Notice of sampling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Notice of sampling. 1500.266 Section 1500.266 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT... Notice of sampling. When a sample of a hazardous substance offered for import has been requested by the...

  11. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  12. 20 CFR 416.266 - Continuation of SSI status for Medicaid

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Continuation of SSI status for Medicaid 416.266 Section 416.266 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  13. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  14. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  15. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  16. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  17. 24 CFR 266.15 - Risk-Sharing Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Risk-Sharing Agreement. 266.15... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.15 Risk-Sharing Agreement. Execution of a Risk-Sharing Agreement is a prerequisite to...

  18. 10 CFR 431.266 - Energy conservation standards and their effective dates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Energy conservation standards and their effective dates. 431.266 Section 431.266 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Commercial Prerinse Spray Valves Energy Conservation Standards...

  19. 10 CFR 431.266 - Energy conservation standards and their effective dates.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Energy conservation standards and their effective dates. 431.266 Section 431.266 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Commercial Prerinse Spray Valves Energy Conservation Standards...

  20. 10 CFR 431.266 - Energy conservation standards and their effective dates.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Energy conservation standards and their effective dates. 431.266 Section 431.266 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Commercial Prerinse Spray Valves Energy Conservation Standards...

  1. 10 CFR 431.266 - Energy conservation standards and their effective dates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Energy conservation standards and their effective dates. 431.266 Section 431.266 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Commercial Prerinse Spray Valves Energy Conservation Standards...

  2. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

  3. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

  4. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

  5. 24 CFR 266.200 - Eligible projects.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

  6. 20 CFR 416.266 - Continuation of SSI status for Medicaid

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Continuation of SSI status for Medicaid 416.266 Section 416.266 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  7. 20 CFR 416.266 - Continuation of SSI status for Medicaid

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Continuation of SSI status for Medicaid 416.266 Section 416.266 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  8. 20 CFR 416.266 - Continuation of SSI status for Medicaid

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Continuation of SSI status for Medicaid 416.266 Section 416.266 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility Special Provisions for People Who Work Despite A...

  9. 42 CFR 422.266 - Beneficiary rebates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., which may include the reduction of cost sharing for benefits under original Medicare and additional... 42 Public Health 3 2010-10-01 2010-10-01 false Beneficiary rebates. 422.266 Section 422.266 Public...) Supplemental health care benefits. MA organizations may apply all or some portion of the rebate for a plan...

  10. 24 CFR 266.5 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Definitions. 266.5 Section 266.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS...

  11. 24 CFR 266.5 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Definitions. 266.5 Section 266.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS...

  12. 24 CFR 266.5 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Definitions. 266.5 Section 266.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS...

  13. 24 CFR 266.5 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Definitions. 266.5 Section 266.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS...

  14. 24 CFR 266.5 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Definitions. 266.5 Section 266.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS...

  15. 20 CFR 266.9 - Responsibilities of a representative payee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Responsibilities of a representative payee. 266.9 Section 266.9 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD... such annuitant, and in a manner and for purposes which are in the annuitant's best interests. (b) A...

  16. 40 CFR 266.205 - Standards applicable to the storage of solid waste military munitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... solid waste military munitions. 266.205 Section 266.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the storage of solid waste military munitions. (a) Criteria for hazardous waste regulation of...

  17. 40 CFR 266.203 - Standards applicable to the transportation of solid waste military munitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... transportation of solid waste military munitions. 266.203 Section 266.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the transportation of solid waste military munitions. (a) Criteria for hazardous waste...

  18. 40 CFR 266.205 - Standards applicable to the storage of solid waste military munitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... solid waste military munitions. 266.205 Section 266.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the storage of solid waste military munitions. (a) Criteria for hazardous waste regulation of...

  19. 40 CFR 266.203 - Standards applicable to the transportation of solid waste military munitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... transportation of solid waste military munitions. 266.203 Section 266.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the transportation of solid waste military munitions. (a) Criteria for hazardous waste...

  20. 40 CFR 266.21 - Standards applicable to generators and transporters of materials used in a manner that...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... transporters of materials used in a manner that constitutes disposal. 266.21 Section 266.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Recyclable...

  1. Survey of Radar Refraction Error Corrections

    DTIC Science & Technology

    2016-11-01

    ELECTRONIC TRAJECTORY MEASUREMENTS GROUP RCC 266-16 SURVEY OF RADAR REFRACTION ERROR CORRECTIONS DISTRIBUTION A: Approved for...DOCUMENT 266-16 SURVEY OF RADAR REFRACTION ERROR CORRECTIONS November 2016 Prepared by Electronic...This page intentionally left blank. Survey of Radar Refraction Error Corrections, RCC 266-16 iii Table of Contents Preface

  2. 7 CFR 1924.266 - Purposes for which claims may be approved.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF AGRICULTURE PROGRAM REGULATIONS CONSTRUCTION AND REPAIR Complaints and Compensation for Construction Defects § 1924.266 Purposes for which claims may be approved. (a) Eligible purposes. A claim may... 7 Agriculture 12 2010-01-01 2010-01-01 false Purposes for which claims may be approved. 1924.266...

  3. 40 CFR 266.101 - Management prior to burning.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Management prior to burning. 266.101... MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.101 Management prior to burning. (a) Generators. Generators of hazardous waste that is burned in a boiler or industrial furnace...

  4. 40 CFR 266.101 - Management prior to burning.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Management prior to burning. 266.101... MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.101 Management prior to burning. (a) Generators. Generators of hazardous waste that is burned in a boiler or industrial furnace...

  5. 40 CFR 266.101 - Management prior to burning.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Management prior to burning. 266.101... MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.101 Management prior to burning. (a) Generators. Generators of hazardous waste that is burned in a boiler or industrial furnace...

  6. 40 CFR 266.101 - Management prior to burning.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Management prior to burning. 266.101... MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.101 Management prior to burning. (a) Generators. Generators of hazardous waste that is burned in a boiler or industrial furnace...

  7. 40 CFR 266.101 - Management prior to burning.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Management prior to burning. 266.101... MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.101 Management prior to burning. (a) Generators. Generators of hazardous waste that is burned in a boiler or industrial furnace...

  8. 40 CFR 266.203 - Standards applicable to the transportation of solid waste military munitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... transportation of solid waste military munitions. 266.203 Section 266.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the transportation of solid waste military munitions. (a) Criteria for hazardous waste...

  9. 40 CFR 266.203 - Standards applicable to the transportation of solid waste military munitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... transportation of solid waste military munitions. 266.203 Section 266.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the transportation of solid waste military munitions. (a) Criteria for hazardous waste...

  10. 40 CFR 266.203 - Standards applicable to the transportation of solid waste military munitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... transportation of solid waste military munitions. 266.203 Section 266.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the transportation of solid waste military munitions. (a) Criteria for hazardous waste...

  11. 18 CFR 284.266 - Rates and charges for interstate pipelines.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 1978 AND RELATED AUTHORITIES Emergency Natural Gas Sale, Transportation, and Exchange Transactions... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Rates and charges for interstate pipelines. 284.266 Section 284.266 Conservation of Power and Water Resources FEDERAL ENERGY...

  12. 7 CFR 2.66 - Director, National Institute of Food and Agriculture.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Director, National Institute of Food and Agriculture. 2.66 Section 2.66 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY THE SECRETARY OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Under...

  13. 7 CFR 2.66 - Director, National Institute of Food and Agriculture.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Director, National Institute of Food and Agriculture. 2.66 Section 2.66 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY THE SECRETARY OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Under...

  14. 7 CFR 2.66 - Director, National Institute of Food and Agriculture.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Director, National Institute of Food and Agriculture. 2.66 Section 2.66 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY THE SECRETARY OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Under...

  15. 7 CFR 2.66 - Director, National Institute of Food and Agriculture.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Director, National Institute of Food and Agriculture. 2.66 Section 2.66 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY THE SECRETARY OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Under...

  16. 24 CFR 266.125 - Scope and nature of sanctions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Scope and nature of sanctions. 266... Housing Finance Agency Requirements § 266.125 Scope and nature of sanctions. (a) Actions by Designated Office. Depending on the nature and extent of the noncompliance with the requirements of this part, the...

  17. 24 CFR 266.215 - Functions delegated by HUD to HFAs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Functions delegated by HUD to HFAs... Program Requirements § 266.215 Functions delegated by HUD to HFAs. The following functions are delegated... functions regarding labor standards, in accordance with § 266.225(e). (Enforcement of Davis-Bacon prevailing...

  18. 40 CFR 266.355 - How could you lose the transportation and disposal conditional exemption for your waste and what...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and disposal conditional exemption for your waste and what actions must you take? 266.355 Section 266.355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  19. 40 CFR 266.355 - How could you lose the transportation and disposal conditional exemption for your waste and what...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and disposal conditional exemption for your waste and what actions must you take? 266.355 Section 266.355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  20. 40 CFR 266.360 - If you lose the transportation and disposal conditional exemption for a waste, can the exemption...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... disposal conditional exemption for a waste, can the exemption be reclaimed? 266.360 Section 266.360 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  1. 40 CFR 266.355 - How could you lose the transportation and disposal conditional exemption for your waste and what...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and disposal conditional exemption for your waste and what actions must you take? 266.355 Section 266.355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  2. 40 CFR 266.355 - How could you lose the transportation and disposal conditional exemption for your waste and what...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and disposal conditional exemption for your waste and what actions must you take? 266.355 Section 266.355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  3. 40 CFR 266.355 - How could you lose the transportation and disposal conditional exemption for your waste and what...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and disposal conditional exemption for your waste and what actions must you take? 266.355 Section 266.355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  4. 40 CFR 266.360 - If you lose the transportation and disposal conditional exemption for a waste, can the exemption...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... disposal conditional exemption for a waste, can the exemption be reclaimed? 266.360 Section 266.360 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  5. 40 CFR 266.360 - If you lose the transportation and disposal conditional exemption for a waste, can the exemption...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disposal conditional exemption for a waste, can the exemption be reclaimed? 266.360 Section 266.360 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT...

  6. 24 CFR 266.125 - Scope and nature of sanctions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Scope and nature of sanctions. 266... Housing Finance Agency Requirements § 266.125 Scope and nature of sanctions. (a) Actions by Designated Office. Depending on the nature and extent of the noncompliance with the requirements of this part, the...

  7. 24 CFR 266.125 - Scope and nature of sanctions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Scope and nature of sanctions. 266... Housing Finance Agency Requirements § 266.125 Scope and nature of sanctions. (a) Actions by Designated Office. Depending on the nature and extent of the noncompliance with the requirements of this part, the...

  8. 24 CFR 266.125 - Scope and nature of sanctions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Scope and nature of sanctions. 266... Housing Finance Agency Requirements § 266.125 Scope and nature of sanctions. (a) Actions by Designated Office. Depending on the nature and extent of the noncompliance with the requirements of this part, the...

  9. 24 CFR 266.125 - Scope and nature of sanctions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Scope and nature of sanctions. 266... Housing Finance Agency Requirements § 266.125 Scope and nature of sanctions. (a) Actions by Designated Office. Depending on the nature and extent of the noncompliance with the requirements of this part, the...

  10. 29 CFR 500.266 - Responsibility of the Office of Administrative Law Judges.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Responsibility of the Office of Administrative Law Judges. 500.266 Section 500.266 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Administrative Proceedings Modification Or Vacation of Order of...

  11. 24 CFR 266.100 - Qualified housing finance agency (HFA).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Qualified housing finance agency (HFA). 266.100 Section 266.100 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE...

  12. Decay properties of {sup 265}Sg(Z=106) and {sup 266}Sg(Z=106)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tuerler, A.; Dressler, R.; Eichler, B.

    1998-04-01

    The presently known most neutron-rich isotopes of element 106 (seaborgium, Sg), {sup 265}Sg and {sup 266}Sg, were produced in the fusion reaction {sup 22}Ne+{sup 248}Cm at beam energies of 121 and 123 MeV. Using the On-Line Gas chemistry Apparatus OLGA, a continuous separation of Sg was achieved within a few seconds. Final products were assayed by {alpha}-particle and spontaneous fission (SF) spectrometry. {sup 265}Sg and {sup 266}Sg were identified by observing time correlated {alpha}-{alpha}-({alpha}) and {alpha}-SF decay chains. A total of 13 correlated decay chains of {sup 265}Sg (with an estimated number of 2.8 random correlations) and 3 decay chainsmore » of {sup 266}Sg (0.6 random correlations) were identified. Deduced decay properties were T{sub 1/2}=7.4{sub {minus}2.7}{sup +3.3} s (68{percent} c.i.) and E{sub {alpha}}=8.69 MeV (8{percent}), 8.76 MeV (23{percent}), 8.84 MeV (46{percent}), and 8.94 MeV (23{percent}) for {sup 265}Sg; and T{sub 1/2}=21{sub {minus}12}{sup +20} s (68{percent} c.i.) and E{sub {alpha}}=8.52 MeV (33{percent}) and 8.77 MeV (66{percent}) for {sup 266}Sg. The resolution of the detectors was between 50{endash}100 keV (full width at half maximum). Upper limits for SF of {le}35{percent} and {le}82{percent} were established for {sup 265}Sg and {sup 266}Sg, respectively. The upper limits for SF are given with a 16{percent} error probability. Using the lower error limits of the half-lives of {sup 265}Sg and {sup 266}Sg, the resulting lower limits for the partial SF half-lives are T{sub 1/2}{sup SF}({sup 265}Sg){ge}13 s and T{sub 1/2}{sup SF}({sup 266}Sg){ge}11 s. Correspondingly, the partial {alpha}-decay half-lives are between T{sub 1/2}{sup {alpha}}({sup 265}Sg)=4.7{endash}16.5 s (68{percent} c.i.) and T{sub 1/2}{sup {alpha}}({sup 266}Sg)=9{endash}228 s (68{percent} c.i.), using the upper and lower error limits of the half-lives of {sup 265}Sg and {sup 266}Sg. The lower limit on the partial SF half-life of {sup 266}Sg is in good agreement with theoretical predictions. Production cross sections of about 240 pb and 25 pb for the {alpha}-decay branch in {sup 265}Sg and {sup 266}Sg were estimated, respectively. {copyright} {ital 1998} {ital The American Physical Society}« less

  13. 40 CFR 266.22 - Standards applicable to storers of materials that are to be used in a manner that constitutes...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... materials that are to be used in a manner that constitutes disposal who are not the ultimate users. 266.22 Section 266.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE...

  14. 40 CFR 266.23 - Standards applicable to users of materials that are used in a manner that constitutes disposal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Recyclable... material, which is contaminated with dioxin or any other hazardous waste (other than a waste identified... materials that are used in a manner that constitutes disposal. 266.23 Section 266.23 Protection of...

  15. 78 FR 22190 - Modification of Area Navigation (RNAV) Route T-266; AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ...; AK AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action... modifying RNAV route T-266 in Alaska. T-266 is currently defined by the Coghland Island, AK, NDB, the Fredericks Point, AK, NDB and the Annette Island, AK, VOR/DME. The Annette Island VOR/DME remains as one end...

  16. 43 CFR 30.266 - When is a final decision issued?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROCEDURES Tribal Purchase of Interests Under Special Statutes § 30.266 When is a final decision issued? This... subject to the tribal purchase option, the decision must so state. (3) A copy of the probate decision... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false When is a final decision issued? 30.266...

  17. RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome

    PubMed Central

    Grinblat, Gabriela A.; Khan, Reas S.; Dine, Kimberly; Wessel, Howard; Brown, Larry; Shindler, Kenneth S.

    2018-01-01

    Purpose Intranasally delivered ST266, the biological, proteinaceous secretome of amnion-derived multipotent progenitor cells, reduces retinal ganglion cell (RGC) loss, optic nerve inflammation, and demyelination in experimental optic neuritis. This unique therapy and novel administration route delivers numerous cytokines and growth factors to the eye and optic nerve, suggesting a potential to also treat other optic neuropathies. Thus, ST266-mediated neuroprotection was examined following traumatic optic nerve injury. Methods Optic nerve crush injury was surgically induced in C57BL/6J mice. Mice were treated daily with intranasal PBS or ST266. RGC function was assessed by optokinetic responses (OKRs), RGCs were counted, and optic nerve sections were stained with luxol fast blue and anti-neurofilament antibodies to assess myelin and RGC axon damage. Results Intranasal ST266 administered daily for 5 days, beginning at the time that a 1-second optic nerve crush was performed, significantly attenuated OKR decreases. Furthermore, ST266 treatment reduced damage to RGC axons and myelin within optic nerves, and blocked RGC loss. Following a 4-second optic nerve crush, intranasal ST266 increased RGC survival and showed a trend toward reduced RGC axon and myelin damage. Ten days following optic nerve crush, ST266 prevented myelin damage, while also inducing a trend toward increased RGC survival and visual function. Conclusions ST266 significantly attenuates traumatic optic neuropathy. Neuroprotective effects of this unique combination of biologic molecules observed here and previously in optic neuritis suggest potential broad application for preventing neuronal damage in multiple optic nerve disorders. Furthermore, results support intranasal delivery as a novel, noninvasive therapeutic modality for eyes and optic nerves. PMID:29847652

  18. Morphological affinities of the Sahelanthropus tchadensis (Late Miocene hominid from Chad) cranium

    PubMed Central

    Guy, Franck; Lieberman, Daniel E.; Pilbeam, David; de León, Marcia Ponce; Likius, Andossa; Mackaye, Hassane T.; Vignaud, Patrick; Zollikofer, Christoph; Brunet, Michel

    2005-01-01

    The recent reconstruction of the Sahelanthropus tchadensis cranium (TM 266-01-60-1) provides an opportunity to examine in detail differences in cranial shape between this earliest-known hominid, African apes, and other hominid taxa. Here we compare the reconstruction of TM 266-01-60-1 with crania of African apes, humans, and several Pliocene hominids. The results not only confirm that TM 266-01-60-1 is a hominid but also reveal a unique mosaic of characters. The TM 266-01-60-1 reconstruction shares many primitive features with chimpanzees but overall is most similar to Australopithecus, particularly in the basicranium. However, TM 266-01-60-1 is distinctive in having the combination of a short subnasal region associated with a vertical upper face that projects substantially in front of the neurocranium. Further research is needed to determine the evolutionary relationships between Sahelanthropus and the known Miocene and Pliocene hominids. PMID:16380424

  19. 26 CFR 1.266-1 - Taxes and carrying charges chargeable to capital account and treated as capital items.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Taxes and carrying charges chargeable to capital account and treated as capital items. 1.266-1 Section 1.266-1 Internal Revenue INTERNAL REVENUE SERVICE... Taxes and carrying charges chargeable to capital account and treated as capital items. (a)(1) In general...

  20. 40 CFR 266.255 - When is your LLMW no longer eligible for the storage and treatment conditional exemption?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false When is your LLMW no longer eligible for the storage and treatment conditional exemption? 266.255 Section 266.255 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES O...

  1. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  2. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  3. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  4. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  5. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  6. Wavelength dependence on the forensic analysis of glass by nanosecond 266 nm and 1064 nm laser induced breakdown spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cahoon, Erica M.; Almirall, Jose R.

    Laser induced breakdown spectroscopy can be used for the chemical characterization of glass to provide evidence of an association between a fragment found at a crime scene to a source of glass of known origin. Two different laser irradiances, 266 nm and 1064 nm, were used to conduct qualitative and quantitative analysis of glass standards. Single-pulse and double-pulse configurations and lens-to-sample-distance settings were optimized to yield the best laser-glass coupling. Laser energy and acquisition timing delays were also optimized to result in the highest signal-to-noise ratio corresponding to the highest precision and accuracy. The crater morphology was examined and themore » mass removed was calculated for both the 266 nm and 1064 nm irradiations. The analytical figures of merit suggest that the 266 nm and 1064 nm wavelengths are capable of good performance for the forensic chemical characterization of glass. The results presented here suggest that the 266 nm laser produces a better laser-glass matrix coupling, resulting in a better stoichiometric representation of the glass sample. The 266 nm irradiance is therefore recommended for the forensic analysis and comparison of glass samples.« less

  7. 24 CFR 266.507 - Maintenance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

  8. 24 CFR 266.105 - Application requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.105 Application requirements. (a) Applications for approval as a HUD...

  9. 24 CFR 266.507 - Maintenance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

  10. 24 CFR 266.507 - Maintenance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

  11. 24 CFR 266.507 - Maintenance requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

  12. 24 CFR 266.507 - Maintenance requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

  13. High-power, high-repetition-rate performance characteristics of β-BaB₂O₄ for single-pass picosecond ultraviolet generation at 266 nm.

    PubMed

    Kumar, S Chaitanya; Casals, J Canals; Wei, Junxiong; Ebrahim-Zadeh, M

    2015-10-19

    We report a systematic study on the performance characteristics of a high-power, high-repetition-rate, picosecond ultraviolet (UV) source at 266 nm based on β-BaB2O4 (BBO). The source, based on single-pass fourth harmonic generation (FHG) of a compact Yb-fiber laser in a two-crystal spatial walk-off compensation scheme, generates up to 2.9 W of average power at 266 nm at a pulse repetition rate of ~80 MHz with a single-pass FHG efficiency of 35% from the green to UV. Detrimental issues such as thermal effects have been studied and confirmed by performing relevant measurements. Angular and temperature acceptance bandwidths in BBO for FHG to 266 nm are experimentally determined, indicating that the effective interaction length is limited by spatial walk-off and thermal gradients under high-power operation. The origin of dynamic color center formation due to two-photon absorption in BBO is investigated by measurements of intensity-dependent transmission at 266 nm. Using a suitable theoretical model, two-photon absorption coefficients as well as the color center densities have been estimated at different temperatures. The measurements show that the two-photon absorption coefficient in BBO at 266 nm is ~3.5 times lower at 200°C compared to that at room temperature. The long-term power stability as well as beam pointing stability is analyzed at different output power levels and focusing conditions. Using cylindrical optics, we have circularized the generated elliptic UV beam to a circularity of >90%. To our knowledge, this is the first time such high average powers and temperature-dependent two-photon absorption measurements at 266 nm are reported at repetition rates as high as ~80 MHz.

  14. 24 CFR 266.110 - Reserve requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.110 Reserve requirements. (a) HFAs with top-tier designation or overall...

  15. 24 CFR 266.520 - Program monitoring and compliance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

  16. 24 CFR 266.520 - Program monitoring and compliance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

  17. 24 CFR 266.520 - Program monitoring and compliance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

  18. 24 CFR 266.520 - Program monitoring and compliance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

  19. 24 CFR 266.520 - Program monitoring and compliance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

  20. 40 CFR 266.204 - Standards applicable to emergency responses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.204 Standards applicable to emergency responses. Explosives and munitions emergencies involving military munitions or explosives are subject to 40...

  1. 40 CFR 266.204 - Standards applicable to emergency responses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.204 Standards applicable to emergency responses. Explosives and munitions emergencies involving military munitions or explosives are subject to 40...

  2. 24 CFR 266.417 - Authority to adjust mortgage insurance amount.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Mortgage and Closing Requirements; HUD Endorsement § 266.417 Authority to adjust mortgage...

  3. ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

    PubMed Central

    2011-01-01

    Background Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). In non-diabetic individuals, the ANGPTL4 coding variant E40K has been associated with lower plasma triglyceride levels while the T266M variant has been associated with more modest effects on triglyceride metabolism. The objective of this study was to determine whether ANGPTL4 E40K and T266M are associated with triglyceride levels in the setting of obesity and T2D, and whether modification of triglyceride levels by these genetic variants is altered by a lifestyle intervention designed to treat T2D. Methods The association of ANGPTL4 E40K and T266M with fasting triglyceride levels was investigated in 2,601 participants from the Look AHEAD Clinical Trial, all of whom had T2D and were at least overweight. Further, we tested for an interaction between genotype and treatment effects on triglyceride levels. Results Among non-Hispanic White Look AHEAD participants, ANGPTL4 K40 carriers had mean triglyceride levels of 1.61 ± 0.62 mmol/L, 0.33 mmol/L lower than E40 homozygotes (p = 0.001). Individuals homozygous for the minor M266 allele (MAF 30%) had triglyceride levels of 1.75 ± 0.58 mmol/L, 0.24 mmol/L lower than T266 homozygotes (p = 0.002). The association of the M266 with triglycerides remained significant even after removing K40 carriers from the analysis (p = 0.002). There was no interaction between the weight loss intervention and genotype on triglyceride levels. Conclusions This is the first study to demonstrate that the ANGPTL4 E40K and T266M variants are associated with lower triglyceride levels in the setting of T2D. In addition, our findings demonstrate that ANGPTL4 genotype status does not alter triglyceride response to a lifestyle intervention in the Look AHEAD study. PMID:21714923

  4. 24 CFR 266.10 - Allocations of assistance and credit subsidy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.10 Allocations of assistance and credit subsidy. (a) Notice of...

  5. 40 CFR 266.200 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FACILITIES Military Munitions § 266.200 Applicability. (a) The regulations in this subpart identify when military munitions become a solid waste, and, if these wastes are also hazardous under this subpart or 40... munitions. ...

  6. 40 CFR 266.200 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FACILITIES Military Munitions § 266.200 Applicability. (a) The regulations in this subpart identify when military munitions become a solid waste, and, if these wastes are also hazardous under this subpart or 40... munitions. ...

  7. 40 CFR 266.200 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FACILITIES Military Munitions § 266.200 Applicability. (a) The regulations in this subpart identify when military munitions become a solid waste, and, if these wastes are also hazardous under this subpart or 40... munitions. ...

  8. 40 CFR 266.200 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FACILITIES Military Munitions § 266.200 Applicability. (a) The regulations in this subpart identify when military munitions become a solid waste, and, if these wastes are also hazardous under this subpart or 40... munitions. ...

  9. 40 CFR 266.200 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FACILITIES Military Munitions § 266.200 Applicability. (a) The regulations in this subpart identify when military munitions become a solid waste, and, if these wastes are also hazardous under this subpart or 40... munitions. ...

  10. 24 CFR 266.616 - Transfer of partial interest under participation agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Assignments § 266.616 Transfer of partial interest...

  11. Surface Mn(II) oxidation actuated by a multicopper oxidase in a soil bacterium leads to the formation of manganese oxide minerals

    PubMed Central

    Zhang, Zhen; Zhang, Zhongming; Chen, Hong; Liu, Jin; Liu, Chang; Ni, Hong; Zhao, Changsong; Ali, Muhammad; Liu, Fan; Li, Lin

    2015-01-01

    In this manuscript, we report that a bacterial multicopper oxidase (MCO266) catalyzes Mn(II) oxidation on the cell surface, resulting in the surface deposition of Mn(III) and Mn(IV) oxides and the gradual formation of bulky oxide aggregates. These aggregates serve as nucleation centers for the formation of Mn oxide micronodules and Mn-rich sediments. A soil-borne Escherichia coli with high Mn(II)-oxidizing activity formed Mn(III)/Mn(IV) oxide deposit layers and aggregates under laboratory culture conditions. We engineered MCO266 onto the cell surfaces of both an activity-negative recipient and wild-type strains. The results confirmed that MCO266 governs Mn(II) oxidation and initiates the formation of deposits and aggregates. By contrast, a cell-free substrate, heat-killed strains, and intracellularly expressed or purified MCO266 failed to catalyze Mn(II) oxidation. However, purified MCO266 exhibited Mn(II)-oxidizing activity when combined with cell outer membrane component (COMC) fractions in vitro. We demonstrated that Mn(II) oxidation and aggregate formation occurred through an oxygen-dependent biotic transformation process that requires a certain minimum Mn(II) concentration. We propose an approximate electron transfer pathway in which MCO266 transfers only one electron to convert Mn(II) to Mn(III) and then cooperates with other COMC electron transporters to transfer the other electron required to oxidize Mn(III) to Mn(IV). PMID:26039669

  12. Surface Mn(II) oxidation actuated by a multicopper oxidase in a soil bacterium leads to the formation of manganese oxide minerals.

    PubMed

    Zhang, Zhen; Zhang, Zhongming; Chen, Hong; Liu, Jin; Liu, Chang; Ni, Hong; Zhao, Changsong; Ali, Muhammad; Liu, Fan; Li, Lin

    2015-06-03

    In this manuscript, we report that a bacterial multicopper oxidase (MCO266) catalyzes Mn(II) oxidation on the cell surface, resulting in the surface deposition of Mn(III) and Mn(IV) oxides and the gradual formation of bulky oxide aggregates. These aggregates serve as nucleation centers for the formation of Mn oxide micronodules and Mn-rich sediments. A soil-borne Escherichia coli with high Mn(II)-oxidizing activity formed Mn(III)/Mn(IV) oxide deposit layers and aggregates under laboratory culture conditions. We engineered MCO266 onto the cell surfaces of both an activity-negative recipient and wild-type strains. The results confirmed that MCO266 governs Mn(II) oxidation and initiates the formation of deposits and aggregates. By contrast, a cell-free substrate, heat-killed strains, and intracellularly expressed or purified MCO266 failed to catalyze Mn(II) oxidation. However, purified MCO266 exhibited Mn(II)-oxidizing activity when combined with cell outer membrane component (COMC) fractions in vitro. We demonstrated that Mn(II) oxidation and aggregate formation occurred through an oxygen-dependent biotic transformation process that requires a certain minimum Mn(II) concentration. We propose an approximate electron transfer pathway in which MCO266 transfers only one electron to convert Mn(II) to Mn(III) and then cooperates with other COMC electron transporters to transfer the other electron required to oxidize Mn(III) to Mn(IV).

  13. Gulf Coast Joint Venture - Contact Us

    Science.gov Websites

    Contact us Gulf Coast Joint Venture Wetland and Aquatic Research Center 700 Cajundome Blvd. Lafayette, LA Coast Joint Venture - 700 Cajundome Blvd. - Lafayette, LA 70506 Phone: 337-266-8801 Fax: 337-266-8800

  14. 24 CFR 266.622 - Notice and date of termination by the Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Termination § 266.622 Notice and date of termination...

  15. 7 CFR 1951.266 - Special requirements for MFH borrowers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Needs and Graduation of Borrowers § 1951.266 Special requirements for MFH borrowers. All requirements of 7 CFR part 3560, subpart K must be met prior to graduation and acceptance of the full payment from...

  16. 7 CFR 1951.266 - Special requirements for MFH borrowers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Needs and Graduation of Borrowers § 1951.266 Special requirements for MFH borrowers. All requirements of 7 CFR part 3560, subpart K must be met prior to graduation and acceptance of the full payment from...

  17. 7 CFR 1951.266 - Special requirements for MFH borrowers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Needs and Graduation of Borrowers § 1951.266 Special requirements for MFH borrowers. All requirements of 7 CFR part 3560, subpart K must be met prior to graduation and acceptance of the full payment from...

  18. 7 CFR 1951.266 - Special requirements for MFH borrowers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Needs and Graduation of Borrowers § 1951.266 Special requirements for MFH borrowers. All requirements of 7 CFR part 3560, subpart K must be met prior to graduation and acceptance of the full payment from...

  19. 7 CFR 1951.266 - Special requirements for MFH borrowers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Needs and Graduation of Borrowers § 1951.266 Special requirements for MFH borrowers. All requirements of 7 CFR part 3560, subpart K must be met prior to graduation and acceptance of the full payment from...

  20. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CFR part 266, subpart F); (iv) Spent lead-acid batteries that are being reclaimed (40 CFR part 266... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  1. 40 CFR 261.6 - Requirements for recyclable materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CFR part 266, subpart F); (iv) Spent lead-acid batteries that are being reclaimed (40 CFR part 266... recycling process itself is exempt from regulation except as provided in § 261.6(d).) (2) Owners or...

  2. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake.

    PubMed

    Ramasamy, Umadevi; Anwer, M Sawkat; Schonhoff, Christopher M

    2013-10-01

    The Na(+) taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. Previously, we demonstrated that nitric oxide (NO) inhibits TC uptake through S-nitrosylation of a cysteine residue. Our current aim was to determine which of the eight cysteine residues of Ntcp is responsible for NO-mediated S-nitrosylation and inhibition of TC uptake. Thus, we tested the effect of NO on TC uptake in HuH-7 cells transiently transfected with cysteine-to-alanine mutant Ntcp constructs. Of the eight mutants tested, only C44A Ntcp displayed decreased total and plasma membrane (PM) levels that were also reflected in decreased TC uptake. C266A Ntcp showed a decrease in TC uptake that was not explained by a decrease in total expression or PM localization, indicating that C266 is required for optimal uptake. We speculated that NO would target C266 since a previous report had shown the thiol reactive compound [2-(trimethylammonium) ethyl] methanethiosulfonate bromide (MTSET) inhibits TC uptake by wild-type NTCP but not by C266A NTCP. We confirmed that MTSET targets C266 of Ntcp, but, surprisingly, we found that C266 was not responsible for NO-mediated inhibition of TC uptake. Instead, we found that C96 was targeted by NO since C96A Ntcp was insensitive to NO-mediated inhibition of TC uptake. We also found that wild-type but not C96A Ntcp is S-nitrosylated by NO, suggesting that C96 is important in regulating Ntcp function in response to elevated levels of NO.

  3. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake

    PubMed Central

    Ramasamy, Umadevi; Anwer, M. Sawkat

    2013-01-01

    The Na+ taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. Previously, we demonstrated that nitric oxide (NO) inhibits TC uptake through S-nitrosylation of a cysteine residue. Our current aim was to determine which of the eight cysteine residues of Ntcp is responsible for NO-mediated S-nitrosylation and inhibition of TC uptake. Thus, we tested the effect of NO on TC uptake in HuH-7 cells transiently transfected with cysteine-to-alanine mutant Ntcp constructs. Of the eight mutants tested, only C44A Ntcp displayed decreased total and plasma membrane (PM) levels that were also reflected in decreased TC uptake. C266A Ntcp showed a decrease in TC uptake that was not explained by a decrease in total expression or PM localization, indicating that C266 is required for optimal uptake. We speculated that NO would target C266 since a previous report had shown the thiol reactive compound [2-(trimethylammonium) ethyl] methanethiosulfonate bromide (MTSET) inhibits TC uptake by wild-type NTCP but not by C266A NTCP. We confirmed that MTSET targets C266 of Ntcp, but, surprisingly, we found that C266 was not responsible for NO-mediated inhibition of TC uptake. Instead, we found that C96 was targeted by NO since C96A Ntcp was insensitive to NO-mediated inhibition of TC uptake. We also found that wild-type but not C96A Ntcp is S-nitrosylated by NO, suggesting that C96 is important in regulating Ntcp function in response to elevated levels of NO. PMID:23886862

  4. Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells*

    PubMed Central

    Kundumani-Sridharan, Venkatesh; Subramani, Jaganathan; Das, Kumuda C.

    2015-01-01

    The mitogen-activated protein kinase kinase 4 (MKK4) is activated via phosphorylation of Ser-257 and Thr-261 by upstream MAP3Ks and activates JNK and p38 MAPKs in response to cellular stress. We show that thioredoxin (Trx), a cellular redox protein, activates MKK4 via Cys-246 and Cys-266 residues as mutation of these residues renders MKK4 insensitive to phosphorylation by MAP3Ks, TNFα, or Trx. MKK4 is activated in vitro by reduced Trx but not oxidized Trx in the absence of an upstream kinase, suggesting that autophosphorylation of this protein occurs due to reduction of Cys-246 and Cys-266 by Trx. Additionally, mutation of Cys-246 and Cys-266 resulted in loss of kinase activity suggesting that the redox state of Cys-246 and Cys-266 is a critical determinant of MKK4 activation. Trx induces manganese superoxide dismutase (MnSOD) gene transcription by activating MKK4 via redox control of Cys-246 and Cys-266, as mutation of these residues abrogates MKK4 activation and MnSOD expression. We further show that MKK4 activates NFκB for its binding to the MnSOD promoter, which leads to AP-1 dissociation followed by MnSOD transcription. Taken together, our studies show that the redox status of Cys-246 and Cys-266 in MKK4 controls its activities independent of MAP3K, demonstrating integration of the endothelial redox environment to MAPK signaling. PMID:26028649

  5. 39 CFR 266.3 - Responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.3... obtain copies of records concerning them. (c) Information System Executive. These managers are... the Federal Register. They establish the relevancy of the information within those systems. (d) Data...

  6. 39 CFR 266.3 - Responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.3... obtain copies of records concerning them. (c) Information System Executive. These managers are... the Federal Register. They establish the relevancy of the information within those systems. (d) Data...

  7. 39 CFR 266.3 - Responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.3... obtain copies of records concerning them. (c) Information System Executive. These managers are... the Federal Register. They establish the relevancy of the information within those systems. (d) Data...

  8. 39 CFR 266.3 - Responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.3... obtain copies of records concerning them. (c) Information System Executive. These managers are... the Federal Register. They establish the relevancy of the information within those systems. (d) Data...

  9. 39 CFR 266.3 - Responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.3... obtain copies of records concerning them. (c) Information System Executive. These managers are... the Federal Register. They establish the relevancy of the information within those systems. (d) Data...

  10. 39 CFR 266.10 - Computer matching.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.10... matching proposals. A proposal must include information required for the matching agreement discussed in... matching proposals, whether from postal organizations or other government agencies, must be mailed directly...

  11. 39 CFR 266.10 - Computer matching.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.10... matching proposals. A proposal must include information required for the matching agreement discussed in... matching proposals, whether from postal organizations or other government agencies, must be mailed directly...

  12. 39 CFR 266.10 - Computer matching.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.10... matching proposals. A proposal must include information required for the matching agreement discussed in... matching proposals, whether from postal organizations or other government agencies, must be mailed directly...

  13. 39 CFR 266.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.1... information collection and usage activities of the entire U.S. Postal Service. This includes the information... any private organization or governmental agency. [40 FR 45723, Oct. 2, 1975] ...

  14. 39 CFR 266.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.1... information collection and usage activities of the entire U.S. Postal Service. This includes the information... any private organization or governmental agency. [40 FR 45723, Oct. 2, 1975] ...

  15. 39 CFR 266.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.1... information collection and usage activities of the entire U.S. Postal Service. This includes the information... any private organization or governmental agency. [40 FR 45723, Oct. 2, 1975] ...

  16. 39 CFR 266.10 - Computer matching.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.10... matching proposals. A proposal must include information required for the matching agreement discussed in... matching proposals, whether from postal organizations or other government agencies, must be mailed directly...

  17. 39 CFR 266.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.1... information collection and usage activities of the entire U.S. Postal Service. This includes the information... any private organization or governmental agency. [40 FR 45723, Oct. 2, 1975] ...

  18. 39 CFR 266.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.1... information collection and usage activities of the entire U.S. Postal Service. This includes the information... any private organization or governmental agency. [40 FR 45723, Oct. 2, 1975] ...

  19. 39 CFR 266.10 - Computer matching.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.10... matching proposals. A proposal must include information required for the matching agreement discussed in... matching proposals, whether from postal organizations or other government agencies, must be mailed directly...

  20. 32 CFR 266.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.1 Purpose. This part: (a) Updates policy, responsibilities, and procedures. (b) Implements Public Law 98-502... to establish audit requirements for State and local governments, institutions of higher education...

  1. 32 CFR 266.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.1 Purpose. This part: (a) Updates policy, responsibilities, and procedures. (b) Implements Public Law 98-502... to establish audit requirements for State and local governments, institutions of higher education...

  2. 32 CFR 266.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.1 Purpose. This part: (a) Updates policy, responsibilities, and procedures. (b) Implements Public Law 98-502... to establish audit requirements for State and local governments, institutions of higher education...

  3. 32 CFR 266.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.1 Purpose. This part: (a) Updates policy, responsibilities, and procedures. (b) Implements Public Law 98-502... to establish audit requirements for State and local governments, institutions of higher education...

  4. 32 CFR 266.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS § 266.1 Purpose. This part: (a) Updates policy, responsibilities, and procedures. (b) Implements Public Law 98-502... to establish audit requirements for State and local governments, institutions of higher education...

  5. RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: Boilers and indutrial furnaces (40 CFR part 266, subpart H) updated as of July 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-11-01

    The module summarizes the regulations affecting hazardous waste processes in boilers and industrial furnaces (BIFs). It defines boilers and industrial furnaces and describes the criteria associated with the definitions. It explains the difference in applicability between regulations found in Part 266, Subpart H, and those found in Part 266, Subpart E. It describes the requirements for processing hazardous waste in BIFs, including the distinctions between permitted and interim status units and explains the requirements for the specially regulated BIF units and gives examples of each.

  6. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Molle, Virginie; Gulten, Gulcin; Vilchèze, Catherine

    The remarkable survival ability of Mycobacterium tuberculosis in infected hosts is related to the presence of cell wall-associated mycolic acids. Despite their importance, the mechanisms that modulate expression of these lipids in response to environmental changes are unknown. Here we demonstrate that the enoyl-ACP reductase activity of InhA, an essential enzyme of the mycolic acid biosynthetic pathway and the primary target of the anti-tubercular drug isoniazid, is controlled via phosphorylation. Thr-266 is the unique kinase phosphoacceptor, both in vitro and in vivo. The physiological relevance of Thr-266 phosphorylation was demonstrated using inhA phosphoablative (T266A) or phosphomimetic (T266D/E) mutants. Enoyl reductasemore » activity was severely impaired in the mimetic mutants in vitro, as a consequence of a reduced binding affinity to NADH. Importantly, introduction of inhA{_}T266D/E failed to complement growth and mycolic acid defects of an inhA-thermosensitive Mycobacterium smegmatis strain, in a similar manner to what is observed following isoniazid treatment. This study suggests that phosphorylation of InhA may represent an unusual mechanism that allows M. tuberculosis to regulate its mycolic acid content, thus offering a new approach to future anti-tuberculosis drug development.« less

  7. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.

    PubMed

    Molle, Virginie; Gulten, Gulcin; Vilchèze, Catherine; Veyron-Churlet, Romain; Zanella-Cléon, Isabelle; Sacchettini, James C; Jacobs, William R; Kremer, Laurent

    2010-12-01

    The remarkable survival ability of Mycobacterium tuberculosis in infected hosts is related to the presence of cell wall-associated mycolic acids. Despite their importance, the mechanisms that modulate expression of these lipids in response to environmental changes are unknown. Here we demonstrate that the enoyl-ACP reductase activity of InhA, an essential enzyme of the mycolic acid biosynthetic pathway and the primary target of the anti-tubercular drug isoniazid, is controlled via phosphorylation. Thr-266 is the unique kinase phosphoacceptor, both in vitro and in vivo. The physiological relevance of Thr-266 phosphorylation was demonstrated using inhA phosphoablative (T266A) or phosphomimetic (T266D/E) mutants. Enoyl reductase activity was severely impaired in the mimetic mutants in vitro, as a consequence of a reduced binding affinity to NADH. Importantly, introduction of inhA_T266D/E failed to complement growth and mycolic acid defects of an inhA-thermosensitive Mycobacterium smegmatis strain, in a similar manner to what is observed following isoniazid treatment. This study suggests that phosphorylation of InhA may represent an unusual mechanism that allows M. tuberculosis to regulate its mycolic acid content, thus offering a new approach to future anti-tuberculosis drug development. © 2010 Blackwell Publishing Ltd.

  8. 39 CFR 266.2 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.2 Policy. It is the... describes any characteristic or provides historical information about an individual or that affords a basis... of any affiliation with an organization or activity, or admission to an institution, is accurate...

  9. 39 CFR 266.2 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.2 Policy. It is the... describes any characteristic or provides historical information about an individual or that affords a basis... of any affiliation with an organization or activity, or admission to an institution, is accurate...

  10. 39 CFR 266.5 - Notification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.5 Notification... reasonable efforts to serve notice on an individual before any personal information on such individual is... request.) (d) Notification of New Use. Any newly intended use of personal information maintained by the...

  11. 39 CFR 266.5 - Notification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.5 Notification... reasonable efforts to serve notice on an individual before any personal information on such individual is... request.) (d) Notification of New Use. Any newly intended use of personal information maintained by the...

  12. 39 CFR 266.2 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.2 Policy. It is the... describes any characteristic or provides historical information about an individual or that affords a basis... of any affiliation with an organization or activity, or admission to an institution, is accurate...

  13. 39 CFR 266.5 - Notification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.5 Notification... reasonable efforts to serve notice on an individual before any personal information on such individual is... request.) (d) Notification of New Use. Any newly intended use of personal information maintained by the...

  14. 39 CFR 266.2 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.2 Policy. It is the... describes any characteristic or provides historical information about an individual or that affords a basis... of any affiliation with an organization or activity, or admission to an institution, is accurate...

  15. 39 CFR 266.5 - Notification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.5 Notification... reasonable efforts to serve notice on an individual before any personal information on such individual is... request.) (d) Notification of New Use. Any newly intended use of personal information maintained by the...

  16. 39 CFR 266.2 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.2 Policy. It is the... describes any characteristic or provides historical information about an individual or that affords a basis... of any affiliation with an organization or activity, or admission to an institution, is accurate...

  17. 39 CFR 266.5 - Notification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION § 266.5 Notification... reasonable efforts to serve notice on an individual before any personal information on such individual is... request.) (d) Notification of New Use. Any newly intended use of personal information maintained by the...

  18. Changes to the Hazardous Waste Federal Regulations Through Part 266 and Part 266 Appendices - Federal Register Notice, February 21, 1991

    EPA Pesticide Factsheets

    Under this final rule, the Environmental Protection Agency (EPA) is expanding controls on hazardous waste combustion to regulate air emissions from the burning of hazardous waste in boilers and industrial furnaces.

  19. 24 CFR 266.510 - HFA responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.510 HFA responsibilities. (a) Inspections. The HFA must perform inspections in accordance with the physical inspection procedures in 24 CFR part 5, subpart G. (b) Annual audits of projects...

  20. 24 CFR 266.100 - Qualified housing finance agency (HFA).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Qualified housing finance agency... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.100 Qualified housing finance agency (HFA). (a) Qualifications...

  1. 24 CFR 266.100 - Qualified housing finance agency (HFA).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Qualified housing finance agency... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.100 Qualified housing finance agency (HFA). (a) Qualifications...

  2. 24 CFR 266.100 - Qualified housing finance agency (HFA).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Qualified housing finance agency... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.100 Qualified housing finance agency (HFA). (a) Qualifications...

  3. 24 CFR 266.100 - Qualified housing finance agency (HFA).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Qualified housing finance agency... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.100 Qualified housing finance agency (HFA). (a) Qualifications...

  4. 24 CFR 266.510 - HFA responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.510 HFA responsibilities. (a) Inspections. The HFA must perform inspections in accordance with the physical inspection procedures in 24 CFR part 5, subpart G. (b) Annual audits of projects...

  5. 24 CFR 266.510 - HFA responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.510 HFA responsibilities. (a) Inspections. The HFA must perform inspections in accordance with the physical inspection procedures in 24 CFR part 5, subpart G. (b) Annual audits of projects...

  6. 24 CFR 266.510 - HFA responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.510 HFA responsibilities. (a) Inspections. The HFA must perform inspections in accordance with the physical inspection procedures in 24 CFR part 5, subpart G. (b) Annual audits of projects...

  7. 24 CFR 266.510 - HFA responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.510 HFA responsibilities. (a) Inspections. The HFA must perform inspections in accordance with the physical inspection procedures in 24 CFR part 5, subpart G. (b) Annual audits of projects...

  8. 40 CFR 266.202 - Definition of solid waste.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not... personnel or explosives and munitions emergency response specialists (including training in proper destruction of unused propellant or other munitions); or (ii) Use in research, development, testing, and...

  9. 40 CFR 266.202 - Definition of solid waste.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not... personnel or explosives and munitions emergency response specialists (including training in proper destruction of unused propellant or other munitions); or (ii) Use in research, development, testing, and...

  10. 40 CFR 266.202 - Definition of solid waste.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not... personnel or explosives and munitions emergency response specialists (including training in proper destruction of unused propellant or other munitions); or (ii) Use in research, development, testing, and...

  11. 24 CFR 266.632 - Withdrawal of claim.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Claim Procedures § 266.632 Withdrawal of claim. In case of a default and... of the type of mortgage relief determined to be appropriate. If the default is cured after the claim...

  12. 266. Photocopy of drawing (1979 piping drawing by StearnsRoger Incorporated) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    266. Photocopy of drawing (1979 piping drawing by Stearns-Roger Incorporated) PIPING PLAN FOR HELIUM AND NITROGEN PUMPING SYSTEMS, SHEET 501-P17 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  13. 24 CFR 266.600 - Mortgage insurance premium: Insurance upon completion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage insurance premium... MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.600 Mortgage insurance premium: Insurance upon completion. (a) Initial premium. For projects insured upon completion, on...

  14. 24 CFR 266.600 - Mortgage insurance premium: Insurance upon completion.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Mortgage insurance premium... MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.600 Mortgage insurance premium: Insurance upon completion. (a) Initial premium. For projects insured upon completion, on...

  15. Decursin chemosensitizes human multiple myeloma cells through inhibition of STAT3 signaling pathway.

    PubMed

    Kim, Hyun Jung; Kim, Sung-Moo; Park, Kyung-Ran; Jang, Hyeung-Jin; Na, Young-Soon; Ahn, Kyoo Seok; Kim, Sung-Hoon; Ahn, Kwang Seok

    2011-02-01

    Recent reports have indicated that decursin can induce apoptosis, suppress tumor growth, and inhibit angiogenesis. In this experiment, we investigated how decursin could potentiate the cytotoxic effects of bortezomib in human multiple myeloma cells. We found that decursin inhibited cell viability in U266, MM.1S and ARH77 cells, but not in peripheral blood mononuclear cells (PBMC). Decursin-induced apoptosis through the activation of caspase-8, -9, and -3 in U266 cells. This correlated with the down-regulating of cyclin D1, bcl-2, bcl-xL, survivin, and the vascular endothelial growth factor (VEGF), which are all regulated by the activation of signal transducers and the activator of transcription 3 (STAT3). Indeed, decursin inhibited constitutive STAT3 activation through inhibition of the activation of Janus-activated kinase 2 (JAK2) in U266 cells. In addition, decursin inhibited interleukin-6-inducible STAT3 activation in a time-dependent manner in MM.1S cells. Interestingly, decursin significantly potentiated the apoptotic effects of bortezomib in U266 cells. These effects of decursin were correlated with the suppression of constitutive STAT3 activation in U266 cells. Overall, these results suggest that decursin is a novel blocker of STAT3 activation and it may be a potential candidate for overcoming chemo-resistance through suppression of this signaling. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  16. 24 CFR 266.415 - Mortgage lien and other obligations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determine, that all contractual obligations in connection with the mortgage transaction, including the... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage lien and other obligations... Mortgage and Closing Requirements; HUD Endorsement § 266.415 Mortgage lien and other obligations. (a) Liens...

  17. 40 CFR 266.106 - Standards to control metals emissions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.106... implemented by limiting feed rates of the individual metals to levels during the trial burn (for new... screening limit for the worst-case stack. (d) Tier III and Adjusted Tier I site-specific risk assessment...

  18. 40 CFR 266.106 - Standards to control metals emissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.106... implemented by limiting feed rates of the individual metals to levels during the trial burn (for new... screening limit for the worst-case stack. (d) Tier III and Adjusted Tier I site-specific risk assessment...

  19. 40 CFR 266.104 - Standards to control organic emissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DRE trial burn. (5) Low risk waste. Owners and operators of boilers or industrial furnaces that burn... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.104...) of this section, a boiler or industrial furnace burning hazardous waste must achieve a destruction...

  20. 40 CFR 266.104 - Standards to control organic emissions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DRE trial burn. (5) Low risk waste. Owners and operators of boilers or industrial furnaces that burn... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.104...) of this section, a boiler or industrial furnace burning hazardous waste must achieve a destruction...

  1. 24 CFR 266.608 - Mortgage insurance premium: Pro rata refund.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage insurance premium: Pro... PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.608 Mortgage insurance premium: Pro rata refund. If the Contract of Insurance is terminated by payment in full or is terminated...

  2. 24 CFR 266.604 - Mortgage insurance premium: Other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage insurance premium: Other... Contract Rights and Obligations Mortgage Insurance Premiums § 266.604 Mortgage insurance premium: Other..., based upon the respective share of risk, that is to be used in calculating mortgage insurance premiums...

  3. 24 CFR 266.602 - Mortgage insurance premium: Insured advances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage insurance premium: Insured... Contract Rights and Obligations Mortgage Insurance Premiums § 266.602 Mortgage insurance premium: Insured.... On each anniversary of the initial closing, the HFA shall pay an interim mortgage insurance premium...

  4. 24 CFR 266.606 - Mortgage insurance premium: Duration and method of paying.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage insurance premium... AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.606 Mortgage insurance premium: Duration and method of paying. (a) Duration of payments. Mortgage insurance...

  5. 24 CFR 266.602 - Mortgage insurance premium: Insured advances.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Mortgage insurance premium: Insured... Contract Rights and Obligations Mortgage Insurance Premiums § 266.602 Mortgage insurance premium: Insured.... On each anniversary of the initial closing, the HFA shall pay an interim mortgage insurance premium...

  6. 24 CFR 266.604 - Mortgage insurance premium: Other requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Mortgage insurance premium: Other... Contract Rights and Obligations Mortgage Insurance Premiums § 266.604 Mortgage insurance premium: Other..., based upon the respective share of risk, that is to be used in calculating mortgage insurance premiums...

  7. 24 CFR 266.606 - Mortgage insurance premium: Duration and method of paying.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Mortgage insurance premium... AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.606 Mortgage insurance premium: Duration and method of paying. (a) Duration of payments. Mortgage insurance...

  8. 24 CFR 266.608 - Mortgage insurance premium: Pro rata refund.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Mortgage insurance premium: Pro... PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.608 Mortgage insurance premium: Pro rata refund. If the Contract of Insurance is terminated by payment in full or is terminated...

  9. 24 CFR 266.310 - Insurance of advances or insurance upon completion; applicability of requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Processing, Development, and Approval § 266.310 Insurance of... projects involving new construction or substantial rehabilitation. Existing projects without the need for...

  10. 37 CFR 2.66 - Revival of abandoned applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Applicants § 2.66 Revival of abandoned applications. (a) The applicant may file a petition to revive an... for filing a petition to revive an application abandoned because the applicant did not timely respond... proposed response. (c) The requirements for filing a petition to revive an application abandoned because...

  11. 40 CFR 266.104 - Standards to control organic emissions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.104...) of this section, a boiler or industrial furnace burning hazardous waste must achieve a destruction... demonstrate conformance with this requirement, 99.99% DRE must be demonstrated during a trial burn for each...

  12. 40 CFR 266.104 - Standards to control organic emissions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.104...) of this section, a boiler or industrial furnace burning hazardous waste must achieve a destruction... demonstrate conformance with this requirement, 99.99% DRE must be demonstrated during a trial burn for each...

  13. 40 CFR 266.104 - Standards to control organic emissions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.104...) of this section, a boiler or industrial furnace burning hazardous waste must achieve a destruction... demonstrate conformance with this requirement, 99.99% DRE must be demonstrated during a trial burn for each...

  14. 40 CFR 266.100 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.100 Applicability. (a) The regulations of this subpart apply to hazardous waste burned or processed in a boiler or industrial furnace (as defined in § 260.10 of this chapter) irrespective of the purpose of burning or processing, except as...

  15. 40 CFR 266.100 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.100 Applicability. (a) The regulations of this subpart apply to hazardous waste burned or processed in a boiler or industrial furnace (as defined in § 260.10 of this chapter) irrespective of the purpose of burning or processing, except as...

  16. 40 CFR 266.100 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.100 Applicability. (a) The regulations of this subpart apply to hazardous waste burned or processed in a boiler or industrial furnace (as defined in § 260.10 of this chapter) irrespective of the purpose of burning or processing, except as...

  17. 7 CFR 1924.266 - Purposes for which claims may be approved.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., flood, tornado, lightning, earthquake or acts of nature which the structure was not designed to... Section 1924.266 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING... be approved to: (1) Pay, or reimburse the borrower for costs already paid, to repair major structural...

  18. 7 CFR 1924.266 - Purposes for which claims may be approved.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., flood, tornado, lightning, earthquake or acts of nature which the structure was not designed to... Section 1924.266 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING... be approved to: (1) Pay, or reimburse the borrower for costs already paid, to repair major structural...

  19. 7 CFR 1924.266 - Purposes for which claims may be approved.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., flood, tornado, lightning, earthquake or acts of nature which the structure was not designed to... Section 1924.266 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING... be approved to: (1) Pay, or reimburse the borrower for costs already paid, to repair major structural...

  20. 40 CFR 266.240 - How could you lose the conditional exemption for your LLMW and what action must you take?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Conditional Exemption for Low-Level Mixed Waste Storage, Treatment, Transportation and Disposal. Loss of Conditional Exemption § 266...

  1. 40 CFR 266.240 - How could you lose the conditional exemption for your LLMW and what action must you take?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Conditional Exemption for Low-Level Mixed Waste Storage, Treatment, Transportation and Disposal Loss of Conditional Exemption § 266...

  2. 40 CFR 266.240 - How could you lose the conditional exemption for your LLMW and what action must you take?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Conditional Exemption for Low-Level Mixed Waste Storage, Treatment, Transportation and Disposal. Loss of Conditional Exemption § 266...

  3. 40 CFR 266.240 - How could you lose the conditional exemption for your LLMW and what action must you take?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Conditional Exemption for Low-Level Mixed Waste Storage, Treatment, Transportation and Disposal Loss of Conditional Exemption § 266...

  4. 24 CFR 266.626 - Notice of default and filing an insurance claim.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Notice of default and filing an... AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Claim Procedures § 266.626 Notice of default and filing an...

  5. 26 CFR 1.401(a)(26)-6 - Excludable employees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Excludable employees. 1.401(a)(26)-6 Section 1... Excludable employees. (a) In general. For purposes of applying section 401(a)(26) with respect to either employees, former employees, or both employees and former employees, as applicable, all employees other than...

  6. 24 CFR 266.400 - Property requirements-real estate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Property requirements-real estate... Mortgage and Closing Requirements; HUD Endorsement § 266.400 Property requirements—real estate. The mortgage must be on real estate held: (a) In fee simple; (b) Under a renewable lease of not less than 99...

  7. 24 CFR 266.400 - Property requirements-real estate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property requirements-real estate... Mortgage and Closing Requirements; HUD Endorsement § 266.400 Property requirements—real estate. The mortgage must be on real estate held: (a) In fee simple; (b) Under a renewable lease of not less than 99...

  8. 24 CFR 266.400 - Property requirements-real estate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Property requirements-real estate... Mortgage and Closing Requirements; HUD Endorsement § 266.400 Property requirements—real estate. The mortgage must be on real estate held: (a) In fee simple; (b) Under a renewable lease of not less than 99...

  9. 24 CFR 266.400 - Property requirements-real estate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Property requirements-real estate... Mortgage and Closing Requirements; HUD Endorsement § 266.400 Property requirements—real estate. The mortgage must be on real estate held: (a) In fee simple; (b) Under a renewable lease of not less than 99...

  10. 24 CFR 266.400 - Property requirements-real estate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Property requirements-real estate... Mortgage and Closing Requirements; HUD Endorsement § 266.400 Property requirements—real estate. The mortgage must be on real estate held: (a) In fee simple; (b) Under a renewable lease of not less than 99...

  11. Fast Facts: Recent Statistics from the Library Research Service, Numbers 266-282. January-December, 2009

    ERIC Educational Resources Information Center

    Library Research Service, 2009

    2009-01-01

    Issues 266 through 282 of "Fast Facts" from the Library Research Service present data collected from libraries in Colorado and throughout the nation. Topics addressed in these "Fast Facts" from 2009 include interlibrary loan in academic libraries, public librarian salaries, book, newspaper, and periodical prices from 2004 to…

  12. 40 CFR 266.107 - Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Industrial Furnaces § 266.107 Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions... streams, including hazardous waste, fuels, and industrial furnace feed stocks shall not exceed the levels...: terrain-adjusted effective stack height, good engineering practice stack height, terrain type, land use...

  13. 40 CFR 266.107 - Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Industrial Furnaces § 266.107 Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions... streams, including hazardous waste, fuels, and industrial furnace feed stocks shall not exceed the levels...: terrain-adjusted effective stack height, good engineering practice stack height, terrain type, land use...

  14. 40 CFR 266.107 - Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Industrial Furnaces § 266.107 Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions... streams, including hazardous waste, fuels, and industrial furnace feed stocks shall not exceed the levels...: terrain-adjusted effective stack height, good engineering practice stack height, terrain type, land use...

  15. 40 CFR 266.107 - Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Industrial Furnaces § 266.107 Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions... streams, including hazardous waste, fuels, and industrial furnace feed stocks shall not exceed the levels...: terrain-adjusted effective stack height, good engineering practice stack height, terrain type, land use...

  16. 40 CFR 266.107 - Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Industrial Furnaces § 266.107 Standards to control hydrogen chloride (HCl) and chlorine gas (Cl2) emissions... streams, including hazardous waste, fuels, and industrial furnace feed stocks shall not exceed the levels...: terrain-adjusted effective stack height, good engineering practice stack height, terrain type, land use...

  17. Lightcurve Analysis of 266 Aline, 664 Judith, (16959) 1998 QE17 and (32910) 1994 TE15

    NASA Astrophysics Data System (ADS)

    Avdellidou, Chrysoula; Ioannidis, Panagiotis; Skoulidou, Despoina K.; Tsiganis, Kleomenis; Seiradakis, John H.

    2012-07-01

    We present the rotation period of three main-belt asteroids: 266 Aline, (16959) 1998 QE17, and (32910) 1994 TE15. Data were obtained but no period found for 664 Judith. The observations were undertaken at Aristotle University's Astronomical Station and Skinakas Observatory during 2010 and 2011.

  18. 40 CFR 266.204 - Standards applicable to emergency responses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.204 Standards applicable to emergency... CFR 262.10(i), 263.10(e), 264.1(g)(8), 265.1(c)(11), and 270.1(c)(3), or alternatively to 40 CFR 270...

  19. 40 CFR 266.204 - Standards applicable to emergency responses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.204 Standards applicable to emergency... CFR 262.10(i), 263.10(e), 264.1(g)(8), 265.1(c)(11), and 270.1(c)(3), or alternatively to 40 CFR 270...

  20. 40 CFR 266.204 - Standards applicable to emergency responses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.204 Standards applicable to emergency... CFR 262.10(i), 263.10(e), 264.1(g)(8), 265.1(c)(11), and 270.1(c)(3), or alternatively to 40 CFR 270...

  1. 78 FR 11987 - Cable Television Act of 1992

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 76 [MM Docket Nos. 92-266 and 93-215, FCC 94-286] Cable Television Act of 1992 AGENCY: Federal Communications Commission. ACTION: Final rule; announcement... Reconsideration and Fifth Report and Order in MM Docket Nos. 92-266 and 93-215; FCC 94-286, published in the...

  2. 49 CFR 266.15 - Requirements for State Rail Plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF TRANSPORTATION ACT § 266.15 Requirements for State Rail Plan. (a) State planning process. The State Rail Plan shall be based on a comprehensive, coordinated and continuing planning process for all... submitted to the Commission for approval or are in the process of negotiation, to the extent that this...

  3. 40 CFR 266.201 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FACILITIES Military Munitions § 266.201 Definitions. In addition to the definitions in 40 CFR 260.10, the... service and is being regularly used for range activities. Chemical agents and munitions are defined as in 50 U.S.C. section 1521(j)(1). Director is as defined in 40 CFR 270.2. Explosives or munitions...

  4. 40 CFR 266.201 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FACILITIES Military Munitions § 266.201 Definitions. In addition to the definitions in 40 CFR 260.10, the... service and is being regularly used for range activities. Chemical agents and munitions are defined as in 50 U.S.C. section 1521(j)(1). Director is as defined in 40 CFR 270.2. Explosives or munitions...

  5. 40 CFR 266.201 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FACILITIES Military Munitions § 266.201 Definitions. In addition to the definitions in 40 CFR 260.10, the... service and is being regularly used for range activities. Chemical agents and munitions are defined as in 50 U.S.C. section 1521(j)(1). Director is as defined in 40 CFR 270.2. Explosives or munitions...

  6. 40 CFR 266.201 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FACILITIES Military Munitions § 266.201 Definitions. In addition to the definitions in 40 CFR 260.10, the... service and is being regularly used for range activities. Chemical agents and munitions are defined as in 50 U.S.C. section 1521(j)(1). Director is as defined in 40 CFR 270.2. Explosives or munitions...

  7. Photodissociation dynamics of Mo(CO) sub 6 at 266 and 355 nm: CO photofragment kinetic-energy and internal-state distributions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Buntin, S.A.; Cavanagh, R.R.; Richter, L.J.

    1991-06-15

    The internal-state and kinetic-energy distributions of the CO photofragments from the 266 and 355 nm photolysis of Mo(CO){sub 6} have been measured under collision-free conditions using vacuum-ultraviolet laser-induced fluorescence. The rotational-state distributions for CO({ital v}{double prime}=0) and ({ital v}{double prime}=1) are well represented by Boltzmann distributions with effective rotational temperatures'' of {ital T}{sub {ital r}}({ital v}{double prime}=0)=950{plus minus}70 K and {ital T}{sub {ital r}}({ital v}{double prime}=1)=935{plus minus}85 K for 266 nm and {ital T}{sub {ital r}}({ital v}{double prime}=0)=750{plus minus}70 K and {ital T}{sub {ital r}}({ital v}{double prime}=1)=1150{plus minus}250 K for 355 nm photolysis. The CO({ital v}{double prime}=1/{ital v}{double prime}=0) vibrational-statemore » ratios for 266 and 355 nm photolysis are 0.19{plus minus}0.03 and 0.09{plus minus}0.02, respectively. The Doppler-broadened CO photofragment line shapes indicate that the translational energy distributions are isotropic and Maxwellian. There is no photolysis-laser wavelength or internal-state dependence to the extracted translational temperatures.'' The observed energy partitioning and kinetic-energy distributions are inconsistent with an impulsive ejection of a single CO ligand. CO photofragment line shapes for 266 nm photolysis are not consistent with a mechanism involving the repulsive ejection of the first CO ligand, followed by the statistical decomposition of the Mo(CO){sub 5} fragment. While phase-space theories do not predict quantitatively the energy disposal, the photodissociation mechanism appears to be dominated by statistical considerations. The results also suggest that the photodissociation of Mo(CO){sub 6} at 266 and 355 nm involves a common initial state'' and that similar exit channel effects are operative.« less

  8. 24 CFR 266.634 - Reinstatement of the contract of insurance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... insurance. (c) Payment. Within 30 days of the date of the notice under paragraph (b) of this section, the HFA shall pay HUD an amount equal to the initial claim amount, as determined under § 266.628(a)(1), plus an amount equal to the accrued and unpaid interest on the HFA Debenture through the reinstatement...

  9. 77 FR 63736 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... matter in the definition of ``regulated NSR pollutant'' found at 45CSR14 section 2.66. Except for this... requirement to include condensable emissions of particulate matter in the definition of ``regulated NSR... particulate matter in the definition of ``regulated NSR pollutant'' found at 45CSR14 section 2.66...

  10. 40 CFR 266.103 - Interim status standards for burners.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... complying with the CO controls of § 266.104(c), the CO limit is established based on the compliance test... testing planned, including a complete copy of the test protocol and Quality Assurance/Quality Control (QA...; (vi) In subpart G (Closure and post-closure), §§ 265.111-265.115; (vii) In subpart H (Financial...

  11. 40 CFR 266.103 - Interim status standards for burners.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... complying with the CO controls of § 266.104(c), the CO limit is established based on the compliance test... testing planned, including a complete copy of the test protocol and Quality Assurance/Quality Control (QA...; (vi) In subpart G (Closure and post-closure), §§ 265.111-265.115; (vii) In subpart H (Financial...

  12. 40 CFR 266.103 - Interim status standards for burners.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... complying with the CO controls of § 266.104(c), the CO limit is established based on the compliance test... testing planned, including a complete copy of the test protocol and Quality Assurance/Quality Control (QA...; (vi) In subpart G (Closure and post-closure), §§ 265.111-265.115; (vii) In subpart H (Financial...

  13. 40 CFR 266.103 - Interim status standards for burners.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... complying with the CO controls of § 266.104(c), the CO limit is established based on the compliance test... testing planned, including a complete copy of the test protocol and Quality Assurance/Quality Control (QA...; (vi) In subpart G (Closure and post-closure), §§ 265.111-265.115; (vii) In subpart H (Financial...

  14. 40 CFR 266.103 - Interim status standards for burners.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... complying with the CO controls of § 266.104(c), the CO limit is established based on the compliance test... testing planned, including a complete copy of the test protocol and Quality Assurance/Quality Control (QA...; (vi) In subpart G (Closure and post-closure), §§ 265.111-265.115; (vii) In subpart H (Financial...

  15. 24 CFR 266.656 - Recovery of costs after final claim settlement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Recovery of costs after final claim... Contract Rights and Obligations Claim Procedures § 266.656 Recovery of costs after final claim settlement. If, after final claim settlement, the HFA recovers additional sums as the result of the sale of the...

  16. 24 CFR 266.656 - Recovery of costs after final claim settlement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Recovery of costs after final claim... Contract Rights and Obligations Claim Procedures § 266.656 Recovery of costs after final claim settlement. If, after final claim settlement, the HFA recovers additional sums as the result of the sale of the...

  17. 24 CFR 266.656 - Recovery of costs after final claim settlement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Recovery of costs after final claim... Contract Rights and Obligations Claim Procedures § 266.656 Recovery of costs after final claim settlement. If, after final claim settlement, the HFA recovers additional sums as the result of the sale of the...

  18. 24 CFR 266.656 - Recovery of costs after final claim settlement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Recovery of costs after final claim... Contract Rights and Obligations Claim Procedures § 266.656 Recovery of costs after final claim settlement. If, after final claim settlement, the HFA recovers additional sums as the result of the sale of the...

  19. 24 CFR 266.656 - Recovery of costs after final claim settlement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Recovery of costs after final claim... Contract Rights and Obligations Claim Procedures § 266.656 Recovery of costs after final claim settlement. If, after final claim settlement, the HFA recovers additional sums as the result of the sale of the...

  20. High-power 266 nm ultraviolet generation in yttrium aluminum borate.

    PubMed

    Liu, Qiang; Yan, Xingpeng; Gong, Mali; Liu, Hua; Zhang, Ge; Ye, Ning

    2011-07-15

    A yttrium aluminum borate [YAl(3)(BO(3))(4)] (YAB) crystal with UV cutoff wavelength of 165 nm is used as the nonlinear optical crystal for fourth harmonic generation. The fundamental frequency laser at 1064 nm from an Nd:YVO(4) master oscillator power amplifier laser was frequency doubled to 532 nm. Using the type I phase-matching YAB crystal, a 5.05 W average power 266 nm UV laser was obtained at the pulse repetition frequency of 65 kHz, corresponding to the conversion efficiency of 12.3% from 532 to 266 nm. The experimental results show great potential for the application of using YAB as a nonlinear optical crystal to get high-power fourth harmonic generation. © 2011 Optical Society of America

  1. ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

    PubMed

    Talmud, Philippa J; Smart, Melissa; Presswood, Edward; Cooper, Jackie A; Nicaud, Viviane; Drenos, Fotios; Palmen, Jutta; Marmot, Michael G; Boekholdt, S Matthijs; Wareham, Nicholas J; Khaw, Kay-Tee; Kumari, Meena; Humphries, Steve E

    2008-12-01

    Angiopoietin-like 4 is a dual-function protein: an inhibitor of LPL, influencing plasma triglycerides (TGs), with angiogenic properties. We examined the association of common ANGPTL4 variants with CHD traits and risk in 5 studies (13,527 individuals). The effects on plasma lipids of 6 tagging SNPs and the recently identified E40K were examined in a study of 2772 men. Only T266M (rs1044250, MAF=30%) and E40K (MAF=2%) were significantly associated with TG-lowering (-10.4%, P<0.004 and -20.4%, P<0.0001), respectively. T266M no longer showed significant associations when K40 carriers (K40+) were excluded (P=0.2). Combining data from 5 studies confirmed the TG-lowering effect of K40+ (weighted mean difference: -0.12 [95% CI -0.18, -0.05] mmol/L TG P=0.0001). Surprisingly, in the 3 prospective studies, the combined OR for CHD was 1.48 (1.11 to 1.96, P=0.007), independent of TG. In individuals with a paternal history of MI (n=332) T266M, but not E40K, showed effects on postprandial AUC TG and glucose (P=0.009 and P=0.017, respectively) compared to controls (n=370). Although associated with an atheroprotective lipid profile, E40K was associated with increased CHD risk, suggesting Angptl4 influences parameters beyond lipid levels. T266M showed effects only under conditions of postprandial stress. The functionality of these potential "loss-of-function" variants needs validation.

  2. The pH-sensitive structure of the C-terminal domain of voltage-gated proton channel and the thermodynamic characteristics of Zn{sup 2+} binding to this domain

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhao, Qing; Li, Chuanyong; Li, Shu Jie, E-mail: shujieli@nankai.edu.cn

    2015-01-02

    Highlights: • The α-helical content of the C-terminus is decreased with a pH increase. • The thermostability of the C-terminus is decreased with a pH increase. • Zn{sup 2+} binds to His{sup 244} and His{sup 266} residues within the C-terminal domain. • The binding of Zn{sup 2+} to His{sup 244} residue is an endothermic heat reaction. • The binding of Zn{sup 2+} to His{sup 266} residue is an exothermic heat reaction. - Abstract: The voltage-gated proton channel Hv1 is strongly sensitive to Zn{sup 2+}. The H{sup +} conduction is decreased at a high concentration of Zn{sup 2+} and Hv1 channelmore » closing is slowed by the internal application of Zn{sup 2+}. Although the recent studies demonstrated that Zn{sup 2+} interacts with the intracellular C-terminal domain, the binding sites and details of the interaction remain unknown. Here, we studied the pH-dependent structural stability of the intracellular C-terminal domain of human Hv1 and showed that Zn{sup 2+} binds to His{sup 244} and His{sup 266} residues. The thermodynamics signature of Zn{sup 2+} binding to the two sites was investigated by isothermal titration calorimetry. The binding of Zn{sup 2+} to His{sup 244} (mutant H266A) and His{sup 266} (mutant H244A) were an endothermic heat reaction and an exothermic heat reaction, respectively.« less

  3. Behavioral Characterization of Knockin Mice with Mutations M287L and Q266I in the Glycine Receptor α1 Subunit

    PubMed Central

    Blednov, Yuri A.; Benavidez, Jill M.; Homanics, Gregg E.

    2012-01-01

    We used behavioral pharmacology to characterize heterozygous knockin mice with mutations (Q266I or M287L) in the α1 subunit of the glycine receptor (GlyR) (J Pharmacol Exp Ther 340:304–316, 2012). These mutations were designed to reduce (M287L) or eliminate (Q266I) ethanol potentiation of GlyR function. We asked which behavioral effects of ethanol would be reduced more in the Q266I mutant than the M287L and found rotarod ataxia to be the behavior that fulfilled this criterion. Compared with controls, the mutant mice also differed in ethanol consumption, ethanol-stimulated startle response, signs of acute physical dependence, and duration of loss of righting response produced by ethanol, butanol, ketamine, pentobarbital, and flurazepam. Some of these behavioral changes were mimicked in wild-type mice by acute injections of low, subconvulsive doses of strychnine. Both mutants showed increased acoustic startle response and increased sensitivity to strychnine seizures. Thus, in addition to reducing ethanol action on the GlyRs, these mutations reduced glycinergic inhibition, which may also alter sensitivity to GABAergic drugs. PMID:22037202

  4. The importance of four histidine residues in isocitrate lyase from Escherichia coli.

    PubMed Central

    Diehl, P; McFadden, B A

    1994-01-01

    By site-directed mutagenesis, substitutions were made for His-184 (H-184), H-197, H-266, and H-306 in Escherichia coli isocitrate lyase. Of these changes, only mutations of H-184 and H-197 appreciably reduced enzyme activity. Mutation of H-184 to Lys, Arg, or Leu resulted in an inactive isocitrate lyase, and mutation of H-184 to Gln resulted in an enzyme with 0.28% activity. Nondenaturing polyacrylamide gel electrophoresis demonstrated that isocitrate lyase containing the Lys, Arg, Gln, and Leu substitutions at H-184 was assembled poorly into the tetrameric subunit complex. Mutation of H-197 to Lys, Arg, Leu, and Gln resulted in an assembled enzyme with less than 0.25% wild-type activity. Five substitutions for H-266 (Asp, Glu, Val, Ser, and Lys), four substitutions for H-306 (Asp, Glu, Val, and Ser), and a variant in which both H-266 and H-306 were substituted for showed little or no effect on enzyme activity. All the H-197, H-266, and H-306 mutants supported the growth of isocitrate lyase-deficient E. coli JE10 on acetate as the sole carbon source; however, the H-184 mutants did not. Images PMID:8300547

  5. 21 CFR 1005.24 - Costs of bringing product into compliance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... at a rate per hour equal to 266 percent of the hourly rate of regular pay of a grade GS-11/4 employee... of regular pay of a grade GS-12/4 employee. (3) The rate per hour equal to 266 percent of the equivalent hourly rate of regular pay of the supervising officer (GS-11/4) and the analyst (GS-12/4) is...

  6. Elm tree (Ulmus parvifolia) bark bioprocessed with Mycelia of Shiitake (Lentinus edodes) mushrooms in liquid Culture: Composition and mechanism of protection against allergic asthma in mice

    USDA-ARS?s Scientific Manuscript database

    The present study investigated the antiasthma effect of a bioprocessed Ulmus parvifolia bark extract (BPUBE) from Lentinus edodes liquid mycelia culture against allergic asthma biomarkers in U266B1 leukemia cells and OVA-sensitized/challenged mice. BPUBE suppressed total IgE release from U266B1 cel...

  7. Industrial R&D Spending Reached $26.6 Billion in 1976. Science Resources Studies Highlights, May 5, 1978.

    ERIC Educational Resources Information Center

    National Science Foundation, Washington, DC. Div. of Science Resources Studies.

    This report presents data compiled as part of a comprehensive program to measure and analyze the nation's resources expended for research and development (R&D). Industry, which carries out 69% of the R&D in the United States, spent $26.6 billion on these activities in 1976, 10% above the 1975 level. In constant dollars, this presents an…

  8. Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets

    PubMed Central

    Litou, Zoi I.; Konstandi, Ourania A.; Giannopoulou, Aikaterini F.; Anastasiadou, Ema; Voutsinas, Gerassimos E.; Tsangaris, George Th.; Stravopodis, Dimitrios J.

    2017-01-01

    Cutaneous melanoma is a malignant tumor of skin melanocytes that are pigment-producing cells located in the basal layer (stratum basale) of epidermis. Accumulation of genetic mutations within their oncogenes or tumor-suppressor genes compels melanocytes to aberrant proliferation and spread to distant organs of the body, thereby resulting in severe and/or lethal malignancy. Metastatic melanoma’s heavy mutational load, molecular heterogeneity and resistance to therapy necessitate the development of novel biomarkers and drug-based protocols that target key proteins involved in perpetuation of the disease. To this direction, we have herein employed a nano liquid chromatography-tandem mass spectrometry (nLC-MS/MS) proteomics technology to profile the deep-proteome landscape of WM-266-4 human metastatic melanoma cells. Our advanced melanoma-specific catalogue proved to contain 6,681 unique proteins, which likely constitute the hitherto largest single cell-line-derived proteomic collection of the disease. Through engagement of UNIPROT, DAVID, KEGG, PANTHER, INTACT, CYTOSCAPE, dbEMT and GAD bioinformatics resources, WM-266-4 melanoma proteins were categorized according to their sub-cellular compartmentalization, function and tumorigenicity, and successfully reassembled in molecular networks and interactomes. The obtained data dictate the presence of plastically inter-converted sub-populations of non-cancer and cancer stem cells, and also indicate the oncoproteomic resemblance of melanoma to glioma and lung cancer. Intriguingly, WM-266-4 cells seem to be subjected to both epithelial-to-mesenchymal (EMT) and mesenchymal-to-epithelial (MET) programs, with 1433G and ADT3 proteins being identified in the EMT/MET molecular interface. Oncogenic addiction of WM-266-4 cells to autocrine/paracrine signaling of IL17-, DLL3-, FGF(2/13)- and OSTP-dependent sub-routines suggests their critical contribution to the metastatic melanoma chemotherapeutic refractoriness. Interestingly, the 1433G family member that is shared between the BRAF- and EMT/MET-specific interactomes likely emerges as a novel and promising druggable target for the malignancy. Derailed proliferation and metastatic capacity of WM-266-4 cells could also derive from their metabolic addiction to pathways associated with glutamate/ammonia, propanoate and sulfur homeostasis, whose successful targeting may prove beneficial for advanced melanoma-affected patients. PMID:28158294

  9. Laser-induced bulk damage of silica glass at 355nm and 266nm

    NASA Astrophysics Data System (ADS)

    Kashiwagi, R.; Aramomi, S.

    2016-12-01

    Laser processing machines using Nd:YAG 3rd harmonic wave (355 nm) and 4th harmonic wave (266 nm) have been developed and put into practical use lately. Due to this, optical elements with high laser durability to 355 nm and 266 nm are required. Silica glass is the optical element which has high UV transmission and high laser durability. Laser-induced surface damage of the silica glass has been studied in detail, but we hardly have the significant knowledge of laserinduced bulk damage. This knowledge is required in order to evaluate the silica glass itself. That is because cracks and scratches on the surface give rise to a higher possibility of damage. Therefore, we studied the laser durability of a variety of the silica glass samples by 1-on-1 and S-on-1 laser-induced bulk damage threshold (LIDT) at 355 nm and 266 nm. In this study, we gained knowledge in three areas about bulk damage to the silica glass. First, the LIDT became lower as shot counts increased. Second, the LIDT decreased as the hydroxyl content in the silica glass increased. Last, the LIDT became higher as the hydrogen concentration in the silica glass increased. Under the UV irradiation, impurities are generated and the silica glass absorbs more light. Therefore, the LIDT decreased as shot counts increased. Also, the hydroxyl in particular generates more impurities, so damage easily occurs. On the other hand, the hydrogen reacts with impurities and absorption is suppressed. Based on these results, we can improve laser durability at 355 nm and 266 nm by reducing the hydroxyl content and increasing the hydrogen concentration in the silica glass.

  10. Time-dependent infrared emission following photodissociation of nitromethane and chloropicrin.

    PubMed

    Wade, Elisabeth A; Reak, Kristina E; Li, Sissi L; Clegg, Samuel M; Zou, Peng; Osborn, David L

    2006-04-06

    Nitromethane (CH(3)NO(2)) and its chlorinated analogue, chloropicrin (CCl(3)NO(2)), were photolyzed at 193, 248, and 266 nm, and the products were observed by time-dependent Fourier transform infrared emission spectroscopy. At 193 and 248 nm, the primary photodissociation pathway for nitromethane was cleavage of the C-N bond to produce CH(3) + NO(2)(A (2)B(2)). At 266 nm, weak emission was observed following photodissociation of nitromethane, but an infrared spectrum could not be obtained. The photodissociation of chloropicrin at 193 nm produced the analogous product channel CCl(3) + NO(2)(A (2)B(2)) in addition to several other product channels. At 248 and 266 nm, only CCl(3) + NO(2)(A (2)B(2)) was observed. The production of phosgene (CCl(2)O) from chloropicrin photodissociation was not observed in this study.

  11. Immunosuppressive effect of extracts from leaves of Fraxinus Mandshurica Rupr.

    PubMed

    Chen, Yujuan; Xue, Gang; Liu, Feizhou; Gong, Xiuling

    2017-05-04

    Plants provide a rich resource of medicinal material for research and development of new medicine. To discover new compounds as Immunosuppressant from plants, we evaluated the immunosuppressive effect of different fractions and particularly one compound (Calceolarioside A) that were extracted from the leaves of Fraxinus Mandshurica Rupr. The fractions and the compound were tested on the ability to reduce Immunoglobulin E (IgE) secretion by human U266 multiple myeloma cells (U266 cells) and to reduce interleukin-2 (IL-2) secretion by mouse spleen cells. Our results showed that both the butanol extract fraction and the compound of Calceolarioside A inhibited the IgE and IL-2 production in U266 cells and mouse spleen cells respectively, and no cytotoxicity was observed within the effective dose range. These results suggest that Calceolarioside A could potentially serve as an immunosuppressant.

  12. Comment on "Applications of homogenous balanced principle on investigating exact solutions to a series of time fractional nonlinear PDEs", [Commun Nonlinear Sci Numer Simulat 47 (2017) 253-266

    NASA Astrophysics Data System (ADS)

    Li, Xiangzheng

    2018-06-01

    A counterexample is given to show that the product rule of the Caputo fractional derivatives does not hold except on a special point. The function-expansion method of separation variable proposed by Rui[Commun Nonlinear Sci Numer Simulat 47 (2017) 253-266] based on the product rule must be modified.

  13. Cognitive-Developmental Learning for a Humanoid Robot: A Caregiver’s Gift

    DTIC Science & Technology

    2004-05-01

    system . We propose a real- time algorithm to infer depth and build 3-dimensional coarse maps for objects through the analysis of cues provided by an... system is well defined at the boundary of these regions (although the derivatives are not). A time domain analysis is presented for a piece-linear... Analysis of Multivariable Systems ......................... 266 D.3.1 Networks of Multiple Neural Oscillators ................. 266 D.3.2 Networks of

  14. Rayleigh scattering cross sections of combustion species at 266, 355, and 532 nm for thermometry applications.

    PubMed

    Sutton, Jeffrey A; Driscoll, James F

    2004-11-15

    Rayleigh scattering cross sections are measured for nine combustion species (Ar, N2, O2, CO2, CO, H2, H2O, CH4, and C3H8) at wavelengths of 266, 355, and 532 nm and at temperatures ranging from 295 to 1525 K. Experimental results show that, as laser wavelengths become shorter, polarization effects become important and the depolarization ratio of the combustion species must be accounted for in the calculation of the Rayleigh scattering cross section. Temperature effects on the scattering cross section are also measured. Only a small temperature dependence is measured for cross sections at 355 nm, resulting in a 2-8% increase in cross section at temperatures of 1500 K. This temperature dependence increases slightly for measurements at 266 nm, resulting in a 5-11% increase in cross sections at temperatures of 1450 K.

  15. Two-photon photoemission from a copper cathode in an Χ-band photoinjector

    DOE PAGES

    Li, H.; Limborg-Deprey, C.; Adolphsen, C.; ...

    2016-02-24

    This study presents two-photon photoemission from a copper cathode in an X-band photoinjector. We experimentally verified that the electron bunch charge from photoemission out of a copper cathode scales with laser intensity (I) square for 400 nm wavelength photons. We compare this two-photon photoemission process with the single photon process at 266 nm. Despite the high reflectivity (R) of the copper surface for 400 nm photons (R=0.48) and higher thermal energy of photoelectrons (two-photon at 200 nm) compared to 266 nm photoelectrons, the quantum efficiency of the two-photon photoemission process (400 nm) exceeds the single-photon process (266 nm) when themore » incident laser intensity is above 300 GW/cm 2. At the same laser pulse energy (E) and other experimental conditions, emitted charge scales inversely with the laser pulse duration. A thermal emittance of 2.7 mm-mrad per mm root mean square (rms) was measured on our cathode which exceeds by sixty percent larger compared to the theoretical predictions, but this discrepancy is similar to previous experimental thermal emittance on copper cathodes with 266 nm photons. The damage of the cathode surface of our first-generation X-band gun from both rf breakdowns and laser impacts mostly explains this result. Using a 400 nm laser can substantially simplify the photoinjector system, and make it an alternative solution for compact pulsed electron sources.« less

  16. miR-211 Plays a Critical Role in Cnidium officinale Makino Extract-Induced, ROS/ER Stress-Mediated Apoptosis in U937 and U266 Cells

    PubMed Central

    Cha, Jin Ah; Song, Hyo-Sook; Kang, Beomku; Park, Moon Nyeo; Park, Kyoung Sun; Shim, Bum-Sang

    2018-01-01

    Though Cnidium officinale Makino (COM) was known to have anti-angiogenic, anti-oxidant, neuroprotective, and anti-cancer effects, the underlying anticancer mechanism of COM using endoplasmic reticulum (ER) stress and miRNA remained unclear until now. Thus, in the current study, the inhibitory mechanism of COM in lymphoma and multiple myeloma (MM) cells was elucidated. COM exerted cytotoxicity in U937 and U266 but not Raw264.7 cells. COM treatment increased the expression of ER stress-related proteins such as p-protein kinase RNA-like endoplasmic reticulum kinase (p-PERK), p-eukaryotic initiation factor (p-eIF2α), and activating transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP). COM also cleaved poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner in both cells. Also, reactive oxygen species (ROS) generation was elevated by COM treatment. Conversely, the apoptotic effect of COM treatment was blocked by N-acetyl-l-cysteine (NAC) pretreatment. Also, the pro-survival miRNA, miR-211 was decreased by COM treatment in U937 and U266 cells. miR-211 mimic attenuated COM-induced apoptosis. Taken together, these results support the scientific evidence that COM induces apoptosis via ROS generation/CHOP activation and miR-211 suppression in U937 and U266 cells. PMID:29543750

  17. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols

    PubMed Central

    Borghese, Cecilia M.; Blednov, Yuri A.; Quan, Yu; Iyer, Sangeetha V.; Xiong, Wei; Mihic, S. John; Zhang, Li; Lovinger, David M.; Trudell, James R.; Homanics, Gregg E.

    2012-01-01

    Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels. Ethanol potentiates glycine activation of the GlyR, and putative binding sites for alcohol are located in the transmembrane (TM) domains between and within subunits. To alter alcohol sensitivity of GlyR, we introduced two mutations in the GlyR α1 subunit, M287L (TM3) and Q266I (TM2). After expression in Xenopus laevis oocytes, both mutants showed a reduction in glycine sensitivity and glycine-induced maximal currents. Activation by taurine, another endogenous agonist, was almost abolished in the M287L GlyR. The ethanol potentiation of glycine currents was reduced in the M287L GlyR and eliminated in Q266I. Physiological levels of zinc (100 nM) potentiate glycine responses in wild-type GlyR and also enhance the ethanol potentiation of glycine responses. Although zinc potentiation of glycine responses was unchanged in both mutants, zinc enhancement of ethanol potentiation of glycine responses was absent in M287L GlyRs. The Q266I mutation decreased conductance but increased mean open time (effects not seen in M287L). Two lines of knockin mice bearing these mutations were developed. Survival of homozygous knockin mice was impaired, probably as a consequence of impaired glycinergic transmission. Glycine showed a decreased capacity for displacing strychnine binding in heterozygous knockin mice. Electrophysiology in isolated neurons of brain stem showed decreased glycine-mediated currents and decreased ethanol potentiation in homozygous knockin mice. Molecular models of the wild-type and mutant GlyRs show a smaller water-filled cavity within the TM domains of the Q266I α1 subunit. The behavioral characterization of these knockin mice is presented in a companion article (J Pharmacol Exp Ther 340:317–329, 2012). PMID:22037201

  18. Skyrme forces and decay of the Rf266*104 nucleus synthesized via different incoming channels

    NASA Astrophysics Data System (ADS)

    Niyti, Deep, Aman; Kharab, Rajesh; Chopra, Sahila; Gupta, Raj K.

    2017-03-01

    The excitation functions for the production of 262Rf, 261Rf, and 260Rf isotopes via 4 n -, 5 n -, and 6 n -decay channels from the *266Rf compound nucleus are studied within the dynamical cluster-decay model (DCM), including deformations β2 i and so-called hot-optimum orientations θi which support symmetric fission, in agreement with experiments. The data are available for 18O+248Cm and 22Ne+244Pu reactions, respectively, at the energy ranges of Elab=88.2 to 101.3 and 109.0 to 124.8 MeV. For the nuclear interaction potentials, we use the Skyrme energy density functional (SEDF) based on semiclassical extended Thomas Fermi (ETF) approach, which means an extension of the earlier study of excitation functions of *266Rf formed in 18O+248Cm reaction, based on the DCM using the pocket formula for nuclear proximity potential, showing interaction dependence. The Skyrme forces used here are the old SIII and SIV and new GSkI and KDE0(v1) given for both normal and isospin-rich nuclei, with densities added in frozen density approximation. Interestingly, the DCM gives an excellent fit to the measured data on fusion evaporation residue (ER) for both the incoming channels (18O+248Cm and 22Ne+244Pu ) at the energy range Elab=88.2 to 124.8 MeV, independent of the entrance channel and Skyrme force used. The possible fusion-fission (ff) and quasifission (qf) mass regions of fragments on DCM are also predicted. The DCM with Skyrme forces is further used to look for all the possible target-projectile (t-p) combinations forming the cold compound nucleus (CN) *266Rf at the CN excitation energy of Elab for hot compact configurations. The fusion evaporation residue cross sections, for the proposed new reactions in synthesizing the CN *266Rf, are also estimated for the future experiments, and role of mass asymmetry of nuclei is indicated.

  19. Preliminary characterisation of new glass reference materials (GSA-1G, GSC-1G, GSD-1G and GSE-1G) by laser ablation-inductively coupled plasma-mass spectrometry using 193 nm, 213 nm and 266 nm wavelengths

    USGS Publications Warehouse

    Guillong, M.; Hametner, K.; Reusser, E.; Wilson, S.A.; Gunther, D.

    2005-01-01

    New glass reference materials GSA-1G, GSC-1G, GSD-1G and GSE-1G have been characterised using a prototype solid state laser ablation system capable of producing wavelengths of 193 nm, 213 nm and 266 nm. This system allowed comparison of the effects of different laser wavelengths under nearly identical ablation and ICP operating conditions. The wavelengths 213 nm and 266 nm were also used at higher energy densities to evaluate the influence of energy density on quantitative analysis. In addition, the glass reference materials were analysed using commercially available 266 nm Nd:YAG and 193 nm ArF excimer lasers. Laser ablation analysis was carried out using both single spot and scanning mode ablation. Using laser ablation ICP-MS, concentrations of fifty-eight elements were determined with external calibration to the NIST SRM 610 glass reference material. Instead of applying the more common internal standardisation procedure, the total concentration of all element oxide concentrations was normalised to 100%. Major element concentrations were compared with those determined by electron microprobe. In addition to NIST SRM 610 for external calibration, USGS BCR-2G was used as a more closely matrix-matched reference material in order to compare the effect of matrix-matched and non matrix-matched calibration on quantitative analysis. The results show that the various laser wavelengths and energy densities applied produced similar results, with the exception of scanning mode ablation at 266 nm without matrix-matched calibration where deviations up to 60% from the average were found. However, results acquired using a scanning mode with a matrix-matched calibration agreed with results obtained by spot analysis. The increased abundance of large particles produced when using a scanning ablation mode with NIST SRM 610, is responsible for elemental fractionation effects caused by incomplete vaporisation of large particles in the ICP.

  20. 40 CFR 180.1281 - S-Abscisic Acid, (S)-5-(1-hydroxy-2,6,6-trimethyl-4-oxo-1-cyclohex-2-enyl)-3-methyl-penta-(2Z,4E...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false S-Abscisic Acid, (S)-5-(1-hydroxy-2,6... Exemptions From Tolerances § 180.1281 S-Abscisic Acid, (S)-5-(1-hydroxy-2,6,6-trimethyl-4-oxo-1-cyclohex-2... from the requirement of a tolerance is established for residues of S-Abscisic Acid in or on all food...

  1. Medical Service Career Ladders AFSC 902X0/A/B/C.

    DTIC Science & Technology

    1986-06-01

    5/9 NL I f Ifl IIIIIIflffl/ EIIIIIIIIIIIIE EI/IIIIIII/IIE EIIIIhiIIIIIIE EiIIIIIIIEIIIE EIIIIIIIIEIIEE LIM,1 1.0 2 = L E3-25 L VICPIi RLSOLUTION TESI ...CARTS 61 E266 INITIATE OR ANNOTATE SF FORMS 553 ( MICROBIOLOGY I) 60 22 time). The Medical superintendent and the CEM perform many of the same tasks...h480 OBTAIN AND RECORD RADIAL PULSE 84 .518 DRIVE CRASH AMBULANCES 84 F266 INITIATE OR ANNOTATE SF FORMS 553 ( MICROBIOLOGY I) 84 E228 INITIATE OR

  2. Biotechnology and Genetic Engineering Reviews. Volume 10

    DTIC Science & Technology

    1992-12-01

    Johnson of Rice University for supplying the graphic of the ce-subunit haem pocket. and Yvonne Le Tellier and Conrad Wheeler of the Blood Research...human hemoglobin cross-linked between the c, chains. J. Bol. Chem. 266- 2697-2700. VANDEGRIFF, K.D., LE TELLIER , Y.C., WINSIoW, R.M., Roili.t:s, R.J...cross-linked between the ax subunits at lysine 99. J. Biol. Chenm. 266, 17 049-17 059. VANDEGRIFF, K.D.. LE TELLIER , Y.C., hESS. J.R. ANt) StIRAGER, R.I

  3. Variants of beta-glucosidase

    DOEpatents

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2015-07-14

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  4. Brazil and the United States: The Need for Strategic Engagement (Strategic Forum, Number 266, March 2011)

    DTIC Science & Technology

    2011-03-01

    If accurate, these astonishing numbers in themselves tell the story of Brazil’s explosive growth. 7 Embrapa is short for Empresa Brasileira de ...in the world. Geography. U.S. citizens think of Brazil as be- ing Rio de Janeiro and its beautiful beaches or as the Amazon, an endless jungle...United States www.ndu.edu/inss SF No. 266 3 and port systems lag. One study suggests that domestic transportation costs and port fees for soy, Brazil’s

  5. Variants of beta-glucosidases

    DOEpatents

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2014-10-07

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  6. Variants of beta-glucosidase

    DOEpatents

    Fidantsef, Ana [Davis, CA; Lamsa, Michael [Davis, CA; Gorre-Clancy, Brian [Elk Grove, CA

    2009-12-29

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  7. Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

    PubMed Central

    Yang, Yul W; Flynn, Ryan A; Chen, Yong; Qu, Kun; Wan, Bingbing; Wang, Kevin C; Lei, Ming; Chang, Howard Y

    2014-01-01

    The WDR5 subunit of the MLL complex enforces active chromatin and can bind RNA; the relationship between these two activities is unclear. Here we identify a RNA binding pocket on WDR5, and discover a WDR5 mutant (F266A) that selectively abrogates RNA binding without affecting MLL complex assembly or catalytic activity. Complementation in ESCs shows that WDR5 F266A mutant is unable to accumulate on chromatin, and is defective in gene activation, maintenance of histone H3 lysine 4 trimethylation, and ESC self renewal. We identify a family of ESC messenger and lncRNAs that interact with wild type WDR5 but not F266A mutant, including several lncRNAs known to be important for ESC gene expression. These results suggest that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates. DOI: http://dx.doi.org/10.7554/eLife.02046.001 PMID:24521543

  8. Generation of continuous-wave 194 nm laser for mercury ion optical frequency standard

    NASA Astrophysics Data System (ADS)

    Zou, Hongxin; Wu, Yue; Chen, Guozhu; Shen, Yong; Liu, Qu; Precision measurement; atomic clock Team

    2015-05-01

    194 nm continuous-wave (CW) laser is an essential part in mercury ion optical frequency standard. The continuous-wave tunable radiation sources in the deep ultraviolet (DUV) region of the spectrum is also serviceable in high-resolution spectroscopy with many atomic and molecular lines. We introduce a scheme to generate continuous-wave 194 nm radiation with SFM in a Beta Barium Borate (BBO) crystal here. The two source beams are at 718 nm and 266 nm, respectively. Due to the property of BBO, critical phase matching (CPM) is implemented. One bow-tie cavity is used to resonantly enhance the 718 nm beam while the 266 nm makes a single pass, which makes the configuration easy to implement. Considering the walk-off effect in CPM, the cavity mode is designed to be elliptical so that the conversion efficiency can be promoted. Since the 266 nm radiation is generated by a 532 nm laser through SHG in a BBO crystal with a large walk-off angle, the output mode is quite non-Gaussian. To improve mode matching, we shaped the 266 nm beam into Gaussian modes with a cylindrical lens and iris diaphragm. As a result, 2.05 mW 194 nm radiation can be generated. As we know, this is the highest power for 194 nm CW laser using SFM in BBO with just single resonance. The work is supported by the National Natural Science Foundation of China (Grant No. 91436103 and No. 11204374).

  9. Trace element analysis of synthetic mono- and poly-crystalline CaF 2 by ultraviolet laser ablation inductively coupled plasma mass spectrometry at 266 and 193 nm

    NASA Astrophysics Data System (ADS)

    Koch, J.; Feldmann, I.; Hattendorf, B.; Günther, D.; Engel, U.; Jakubowski, N.; Bolshov, M.; Niemax, K.; Hergenröder, R.

    2002-06-01

    The analytical figures of merit for ultraviolet laser ablation-inductively coupled plasma mass spectrometry (UV-LA-ICP-MS) at 266 nm with respect to the trace element analysis of high-purity, UV-transmitting alkaline earth halides are investigated and discussed. Ablation threshold energy density values and ablation rates for mono- and poly-crystalline CaF 2 samples were determined. Furthermore, Pb-, Rb-, Sr-, Ba- and Yb-specific analysis was performed. For these purposes, a pulsed Nd:YAG laser operated at the fourth harmonic of the fundamental wavelength (λ=266 nm) and a double-focusing sector field ICP-MS detector were employed. Depending on the background noise and isotope-specific sensitivity, the detection limits typically varied from 0.7 ng/g for Sr to 7 ng/g in the case of Pb. The concentrations were determined using a glass standard reference material (SRM NIST612). In order to demonstrate the sensitivity of the arrangement described, comparative measurements by means of a commercial ablation system consisting of an ArF excimer laser (λ=193 nm) and a quadrupole-type ICP-MS (ICP-QMS) instrument were carried out. The accuracy of both analyses was in good agreement, whereas ablation at 266 nm and detection using sector-field ICP-MS led to a sensitivity that was one order of magnitude above that obtained at 193 nm with ICP-QMS.

  10. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy.

    PubMed

    Hogg, Marion; Grujic, Zoran M; Baker, Matt; Demirci, Serpil; Guillozet, Angela L; Sweet, Alison P; Herzog, Laura L; Weintraub, Sandra; Mesulam, M-Marsel; LaPointe, Nichole E; Gamblin, T C; Berry, Robert W; Binder, Lester I; de Silva, Rohan; Lees, Andrew; Espinoza, Marisol; Davies, Peter; Grover, Andrew; Sahara, Naruhiko; Ishizawa, Takashi; Dickson, Dennis; Yen, Shu-Hui; Hutton, Michael; Bigio, Eileen H

    2003-10-01

    We report a case of rapidly progressive frontotemporal dementia presenting at age 33 years. At autopsy there was severe atrophy of the frontal and temporal lobes. Tau-positive Pick bodies, which ultrastructurally were composed of straight filaments, were present, accompanied by severe neuronal loss and gliosis. RD3, a tau antibody specific for the three-repeat (3R) isoforms, labeled the Pick bodies. ET3, a four-repeat (4R) isoform-specific tau antibody, did not label Pick bodies, but highlighted rare astrocytes, and threads in white matter bundles in the corpus striatum. Analysis of the tau gene revealed an L266V mutation in exon 9. Analysis of brain tissue from this case revealed elevated levels of exon 10+ tau RNA and soluble 4R tau. However, both 3R and 4R isoforms were present in sarkosyl-insoluble tau fractions with a predominance of the shortest 3R isoform. The L266V mutation is associated with decreased rate and extent of tau-induced microtubule assembly, and a 3R isoform-specific increase in tau self assembly as measured by an in vitro assay. Combined, these data indicate that L266V is a pathogenic tau mutation that is associated with Pick-like pathology. In addition, the results of the RD3 and ET3 immunostains clearly explain for the first time the presence of both 3R and 4R tau isoforms in preparations of insoluble tau from some Pick's disease cases.

  11. Efficient 2(nd) and 4(th) harmonic generation of a single-frequency, continuous-wave fiber amplifier.

    PubMed

    Sudmeyer, Thomas; Imai, Yutaka; Masuda, Hisashi; Eguchi, Naoya; Saito, Masaki; Kubota, Shigeo

    2008-02-04

    We demonstrate efficient cavity-enhanced second and fourth harmonic generation of an air-cooled, continuous-wave (cw), single-frequency 1064 nm fiber-amplifier system. The second harmonic generator achieves up to 88% total external conversion efficiency, generating more than 20-W power at 532 nm wavelength in a diffraction-limited beam (M(2) < 1.05). The nonlinear medium is a critically phase-matched, 20-mm long, anti-reflection (AR) coated LBO crystal operated at 25 degrees C. The fourth harmonic generator is based on an AR-coated, Czochralski-grown beta-BaB(2)O(4) (BBO) crystal optimized for low loss and high damage threshold. Up to 12.2 W of 266-nm deep-UV (DUV) output is obtained using a 6-mm long critically phase-matched BBO operated at 40 degrees C. This power level is more than two times higher than previously reported for cw 266-nm generation. The total external conversion efficiency from the fundamental at 1064 nm to the fourth harmonic at 266 nm is >50%.

  12. Using an Inductive Learning Algorithm to Improve Antibody Generation in a Single Packet Computer Defense Immune System

    DTIC Science & Technology

    2002-03-01

    allow the network to perform as a much better classifier. Another disadvantage of neural networks is that it is difficult to know what is going on...could be shown to have a cause and effect relationship in producing bad antibodies, the next phase of the research was destined to go more smoothly...Number Bad 2,402 1,803 80 253 266 Training File Number Good 1,201 316 307 312 266 Number Bad 1,201 901 40 127 133 Testing File Number Good 1,201 322 333

  13. REMPI-TOFMS for on-line monitoring and controlling the coffee roasting process

    NASA Astrophysics Data System (ADS)

    Dorfner, Ralph; Ferge, Thomas; Yeretzian, Chahan; Zimmermann, Ralf; Kettrup, Antonius

    2001-08-01

    REMPI@266nm-TOFMS is used for on-line analysis of the coffee roasting process. Volatile and flavor active compounds of coffee were ionized by REMPI@266nm and monitored on-line and in real-time by TOFMS during the coffee roasting process. The phenol and 4-vinylguaiacol time-intensity profiles, for example, show typical behavior for different roasting temperatures and provide an indicator to the achieved degree of roasting. The impact of the moisture level of the green coffee beans on the time shift of a typical (commercial) roasting time, correlates with REMPI-TOFMS measurements and literature data.

  14. LIDAR Remote Sensing of Particulate Matter Emissions from On-Road Vehicles

    NASA Astrophysics Data System (ADS)

    Keislar, R. E.; Kuhns, H.; Mazzoleni, C.; Moosmuller, H.; Watson, J.

    2002-12-01

    DRI has developed a remote sensing method for on-road particulate matter emissions from gasoline-powered and diesel-powered vehicles called the Vehicle Emissions Remote Sensing System (VERSS). Remote sensing of gaseous pollutants in vehicle exhaust is a well-established, economical way to determine on-road emissions for thousands of vehicles per day. The VERSS adds a particulate matter channel to complement gaseous pollutant measurements. The VERSS uses 266-nm ultraviolet laser light to achieve greater sensitivity than visible light to sub-micrometer particles, where the greatest mass fraction has been reported. The VERSS system integrates the lidar channel with a commercial remote sensing device (RSD) for gaseous pollutants, and the RSD CO2 measurement can be used to estimate fuel-based particle mass emissions. We describe the interpretation and processing of lidar returns from field measurements taken by the combined VERSS during the Southern Nevada Air Quality Study (SNAQS), conducted in the Las Vegas area. With suitable assumptions regarding size distribution and particle composition, the lidar backscatter signal and the RSD yield three basic measurements of particulate matter in the exhaust plume. For each passing vehicle, these three channels are: 1) Columnar extinction in the infrared (IR at 3.9 micrometers) 2) Columnar extinction in the ultraviolet (UV at 266 nm) 3) Range-resolved backscatter at 266 nm (horizontal spatial resolution of 20-25 cm) The 3.9-micrometer channel is a good surrogate for absorption by elemental carbon (EC) in tailpipe emissions and has been utilized in previous studies. Opacity measurements at 266 nm provide optical extinction due to scattering from tailpipe organic carbon (OC) and EC emissions.

  15. The BRAF inhibitor vemurafenib activates mitochondrial metabolism and inhibits hyperpolarized pyruvate-lactate exchange in BRAF mutant human melanoma cells

    PubMed Central

    Delgado-Goni, Teresa; Falck Miniotis, Maria; Wantuch, Slawomir; Parkes, Harold G.; Marais, Richard; Workman, Paul; Leach, Martin O.; Beloueche-Babari, Mounia

    2016-01-01

    Understanding the impact of BRAF signaling inhibition in human melanoma on key disease mechanisms is important for developing biomarkers of therapeutic response and combination strategies to improve long term disease control. This work investigates the downstream metabolic consequences of BRAF inhibition with vemurafenib, the molecular and biochemical processes that underpin them, their significance for antineoplastic activity and potential as non-invasive imaging response biomarkers.1H NMR spectroscopy showed that vemurafenib decreases the glycolytic activity of BRAF mutant (WM266.4 and SKMEL28) but not BRAFWT (CHL-1 and D04) human melanoma cells. In WM266.4 cells, this was associated with increased acetate, glycine and myo-inositol levels and decreased fatty acyl signals, while the bioenergetic status was maintained. 13C NMR metabolic flux analysis of treated WM266.4 cells revealed inhibition of de novo lactate synthesis and glucose utilization, associated with increased oxidative and anaplerotic pyruvate carboxylase mitochondrial metabolism and decreased lipid synthesis. This metabolic shift was associated with depletion of HKII, acyl-CoA dehydrogenase 9, 3-phosphoglycerate dehydrogenase and monocarboxylate transporter (MCT) 1 and 4 in BRAF mutant but not BRAFWT cells and, interestingly, decreased BRAF mutant cell dependency on glucose and glutamine for growth. Further, the reduction in MCT1 expression observed led to inhibition of hyperpolarized 13C-pyruvate-lactate exchange, a parameter that is translatable to in vivo imaging studies, in live WM266.4 cells. In conclusion, our data provide new insights into the molecular and metabolic consequences of BRAF inhibition in BRAF-driven human melanoma cells that may have potential for combinatorial therapeutic targeting as well as non-invasive imaging of response. PMID:27765851

  16. Lower-free tropospheric ozone dial measurements over Athens, Greece

    NASA Astrophysics Data System (ADS)

    Mytilinaios, Michail; Papayannis, Alexandros; Tsaknakis, Georgios

    2018-04-01

    A compact ozone differential absorption lidar (DIAL) was implemented at the Laboratory of Laser Remote Sensing of the National Technical University of Athens (NTUA), in Athens, Greece. The DIAL system is based on a Nd:YAG laser emitting at 266 nm. A high-pressure Raman cell, filled with D2, was used to generate the λON and λOFF laser wavelength pairs (i.e., 266-289 nm and 289-316 nm, respectively) based on the Stimulated Raman Scattering (SRS) effect. The system was run during daytime and nighttime conditions to obtain the vertical profile of tropospheric ozone in the Planetary Boundary Layer (PBL) and the adjacent free troposphere.

  17. Ultrafast primary processes of an iron-(III) azido complex in solution induced with 266 nm light.

    PubMed

    Vennekate, Hendrik; Schwarzer, Dirk; Torres-Alacan, Joel; Krahe, Oliver; Filippou, Alexander C; Neese, Frank; Vöhringer, Peter

    2012-05-14

    The ultrafast photo-induced primary processes of the iron-(III) azido complex, [Fe(III)N(3)(cyclam-acetato)] PF(6) (1), in acetonitrile solution at room temperature were studied using femtosecond spectroscopy with ultraviolet (UV) excitation and mid-infrared (MIR) detection. Following the absorption of a 266 nm photon, the complex undergoes an internal conversion back to the electronic doublet ground state at a time scale below 2 ps. Subsequently, the electronic ground state vibrationally cools with a characteristic time constant of 13 ps. A homolytic bond cleavage was also observed by the appearance of ground state azide radicals, which were identified by their asymmetric stretching vibration at 1659 cm(-1). The azide radical recombines in a geminate fashion with the iron containing fragment within 20 ps. The cage escape leading to well separated fragments after homolytic Fe-N bond breakage was found to occur with a quantum yield of 35%. Finally, non-geminate recombination at nanosecond time scales was seen to further reduce the photolytic quantum yield to below 20% at a wavelength of 266 nm. This journal is © the Owner Societies 2012

  18. Pharmacokinetic profile of liposome bupivacaine injection following a single administration at the surgical site.

    PubMed

    Hu, DeeDee; Onel, Erol; Singla, Neil; Kramer, William G; Hadzic, Admir

    2013-02-01

    Local anaesthetics are often used as part of multimodal pain management techniques to manage postsurgical pain and lessen the need for opioid analgesics; however, the duration of action of traditional formulations of local anaesthetics is short. Liposome bupivacaine is a novel, multivesicular formulation designed for rapid absorption, prolonged release of bupivacaine, and analgesia following a single intra-operative administration into the surgical wound. This article provides a summary of the pharmacokinetic profile of liposome bupivacaine compared with bupivacaine HCl based on data compiled from four randomized, active- and placebo-controlled trials that included pharmacokinetic assessments following single administrations of study drug. Each study evaluated the safety, efficacy and pharmacokinetic profile of liposome bupivacaine in separate surgical populations (patients undergoing inguinal hernia repair, total knee arthroplasty, haemorrhoidectomy or bunionectomy). Pharmacokinetic parameters included maximum plasma drug concentration (C(max)), area under the curve (AUC) for plasma bupivacaine concentration over time extrapolated to infinity (AUC(∞)), time to observed C(max) (t(max)) and terminal elimination half-life of bupivacaine (t(½)). The studies assessed single administrations of liposome bupivacaine at dose levels ranging from 106 to 532 mg or bupivacaine HCl 100 to 150 mg or placebo (0.9 % sodium chloride) given locally via wound infiltration at the end of surgery prior to wound closure. Male and non-pregnant female patients (n = 253) aged ≥18 years, scheduled to undergo surgery as per the specific protocol for each study, were enrolled. Patient characteristics were stratified by liposome bupivacaine doses ≤266 mg and >266 mg, and bupivacaine HCl treatment arms. Pharmacokinetic parameters for liposome bupivacaine doses of 106, 266, 399 and 532 mg were compared. Plasma concentration versus time profiles were quantitatively similar across these four dose levels of liposome bupivacaine, with an initial peak occurring within 1 h after administration followed by a second peak about 12-36 h later. The overall incidence of adverse events was lower in the liposome bupivacaine ≤266-mg group than the liposome bupivacaine >266-mg and bupivacaine HCl groups (100- or 150-mg doses). In summary, liposome bupivacaine was well tolerated across the four studies and varied surgical models, and exhibited bimodal kinetics with rapid uptake observed during the first few hours and prolonged release through 96 h after administration.

  19. Demonstration of miniaturized 20mW CW 280nm and 266nm solid-state UV laser sources

    NASA Astrophysics Data System (ADS)

    Landru, Nicolas; Georges, Thierry; Beaurepaire, Julien; Le Guen, Bruno; Le Bail, Guy

    2015-02-01

    Visible 561 nm and 532 nm laser emissions from 14-mm long DPSS monolithic cavities are frequency converted to deep UV 280 nm and 266 nm in 16-mm long monolithic external cavities. Wavelength conversion is fully insensitive to mechanical vibrations and the whole UV laser sources fit in a miniaturized housing. More than 20 mW deep UV laser emission is demonstrated with high power stability, low noise and good beam quality. Aging tests are in progress but long lifetimes are expected thanks to the cavity design. Protein detection and deep UV resonant Raman spectroscopy are applications that could benefit from these laser sources.

  20. Comparative in vitro activities of XRP 2868, pristinamycin, quinupristin-dalfopristin, vancomycin, daptomycin, linezolid, clarithromycin, telithromycin, clindamycin, and ampicillin against anaerobic gram-positive species, actinomycetes, and lactobacilli.

    PubMed

    Goldstein, Ellie J C; Citron, Diane M; Merriam, C Vreni; Warren, Yumi A; Tyrrell, Kerin L; Fernandez, Helen T; Bryskier, Andre

    2005-01-01

    A comparative study of the in vitro activities of XRP 2868, a new oral streptogramin, against 266 anaerobic gram-positive clinical isolates using the agar dilution method showed that the XRP 2868 MICs for 95% (254 of 266) of isolates were < or =0.5 microg/ml. XRP 2868 MICs for only two strains, one being Clostridium clostridioforme (MIC, 16 microg/ml) and the other being Clostridium difficile (MIC, 32 microg/ml), were >2 microg/ml. Depending on its pharmacokinetics and pharmacodynamics, XRP 2868 has potential for use against infections with gram-positive anaerobes and deserves further clinical evaluation.

  1. Laser desorption of explosives as a way to create an effective non-contact sampling device

    NASA Astrophysics Data System (ADS)

    Akmalov, Artem E.; Chistyakov, Alexander A.; Kotkovskii, Gennadii E.

    2015-10-01

    Comparison of desorption effectiveness of Nd3+:YAG nanosecond laser sources (λ=266, 354, 532 nm) has been carried out to investigate a possibility of creating a non-contact sampling device for detectors of explosives based on principles of ion mobility spectrometry (IMS) and field asymmetric ion mobility spectrometry (FAIMS). The results of mass spectrometric study of laser desorption of nitroamine, nitrate ester and nitroaromatic compounds from a quartz substrate are presented. It is shown that irradiation of adsorbed layers of studied samples by a single pulse of non-resonant laser radiation (λ=532 nm) leads to efficient desorption at laser intensity 107 W/cm2 and above. Excitation of the first singlet state of nitro compounds by resonant radiation (λ=354 nm) provides heating of adsorbed layers and thermal desorption. A strongly non-equilibrium (non-thermal) dissociation process is developed when the second singlet state of nitroaromatic molecules is excited by radiation at λ=266 nm, along with thermal desorption. It is shown that Nd3+: YAG laser with wavelength λ=266 nm, pulse duration 5-10 ns, intensity 107-109 W/cm2 is the most effective source for creation a non-contact sampling device based on desorption of explosives from surfaces.

  2. Peginterferon Beta-1a Shows Antitumor Activity as a Single Agent and Enhances Efficacy of Standard of Care Cancer Therapeutics in Human Melanoma, Breast, Renal, and Colon Xenograft Models.

    PubMed

    Boccia, Antonio; Virata, Cyrus; Lindner, Daniel; English, Nicki; Pathan, Nuzhat; Brickelmaier, Margot; Hu, Xiao; Gardner, Jennifer L; Peng, Liaomin; Wang, Xinzhong; Zhang, Xiamei; Yang, Lu; Perron, Keli; Yco, Grace; Kelly, Rebecca; Gamez, James; Scripps, Thomas; Bennett, Donald; Joseph, Ingrid B; Baker, Darren P

    2017-01-01

    Because of its tumor-suppressive effect, interferon-based therapy has been used for the treatment of melanoma. However, limited data are available regarding the antitumor effects of pegylated interferons, either alone or in combination with approved anticancer drugs. We report that treatment of human WM-266-4 melanoma cells with peginterferon beta-1a induced apoptotic markers. Additionally, peginterferon beta-1a significantly inhibited the growth of human SK-MEL-1, A-375, and WM-266-4 melanoma xenografts established in immunocompromised mice. Peginterferon beta-1a regressed large, established WM-266-4 xenografts in nude mice. Treatment of SK-MEL-1 tumor-bearing mice with a combination of peginterferon beta-1a and the MEK inhibitor PD325901 ((R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide) significantly improved tumor growth inhibition compared with either agent alone. Examination of the antitumor activity of peginterferon beta-1a in combination with approved anticancer drugs in breast and renal carcinomas revealed improved antitumor activity in these preclinical xenograft models, as did the combination of peginterferon beta-1a and bevacizumab in a colon carcinoma xenograft model.

  3. High efficiency fourth-harmonic generation from nanosecond fiber master oscillator power amplifier

    NASA Astrophysics Data System (ADS)

    Mu, Xiaodong; Steinvurzel, Paul; Rose, Todd S.; Lotshaw, William T.; Beck, Steven M.; Clemmons, James H.

    2016-03-01

    We demonstrate high power, deep ultraviolet (DUV) conversion to 266 nm through frequency quadrupling of a nanosecond pulse width 1064 nm fiber master oscillator power amplifier (MOPA). The MOPA system uses an Yb-doped double-clad polarization-maintaining large mode area tapered fiber as the final gain stage to generate 0.5-mJ, 10 W, 1.7- ns single mode pulses at a repetition rate of 20 kHz with measured spectral bandwidth of 10.6 GHz (40 pm), and beam qualities of Mx 2=1.07 and My 2=1.03, respectively. Using LBO and BBO crystals for the second-harmonic generation (SHG) and fourth-harmonic generation (FHG), we have achieved 375 μJ (7.5 W) and 92.5 μJ (1.85 W) at wavelengths of 532 nm and 266 nm, respectively. To the best of our knowledge these are the highest narrowband infrared, green and UV pulse energies obtained to date from a fully spliced fiber amplifier. We also demonstrate high efficiency SHG and FHG with walk-off compensated (WOC) crystal pairs and tightly focused pump beam. An SHG efficiency of 75%, FHG efficiency of 47%, and an overall efficiency of 35% from 1064 nm to 266 nm are obtained.

  4. Real-time monitoring of BTEX in air via ambient-pressure MPI

    NASA Astrophysics Data System (ADS)

    Swenson, Orven F.; Carriere, Josef P.; Isensee, Harlan; Gillispie, Gregory D.; Cooper, William F.; Dvorak, Michael A.

    1998-05-01

    We have developed and begun to field test a very sensitive method for real-time measurements of single-ring aromatic hydrocarbons in ambient air. In this study, we focus on the efficient 1 + 1 resonance enhanced multiphoton ionization (REMPI) of the BTEX species in the narrow region between 266 and 267 nm. We particularly emphasize 266.7 nm, a wavelength at which both benzene and toluene exhibit a sharp absorbance feature and benzene and its alkylated derivatives all absorb. An optical parametric oscillator system generating 266.7 nm, a REMPI cell, and digital oscilloscope detector are mounted on a breadboard attached to a small cart. In the first field test, the cart was wheeled through the various rooms of a chemistry research complex. Leakage of fuel through the gas caps of cars and light trucks in a parking lot was the subject of the second field test. The same apparatus was also used for a study in which the performance of the REMPI detector and a conventional photoionization detector were compared as a BTEX mixture was eluted by gas chromatography. Among the potential applications of the methodology are on-site analysis of combustion and manufacturing processes, soil gas and water headspace monitoring, space cabin and building air quality, and fuel leak detection.

  5. Diode-pumped DUV cw all-solid-state laser to replace argon ion lasers

    NASA Astrophysics Data System (ADS)

    Zanger, Ekhard; Liu, B.; Gries, Wolfgang

    2000-04-01

    The slim series DELTATRAINTM-worldwide the first integrated cw diode-pumped all-solid-state DUV laser at 266 nm with a compact, slim design-has been developed. The slim design minimizes the DUV DPSSL footprint and thus greatly facilitates the replacement of commonly used gas ion lasers, including these with intra-cavity frequency doubling, in numerous industrial and scientific applications. Such a replacement will result in an operation cost reduction by several thousands US$DLR each year for one unit. Owing to its unique geometry-invariant frequency doubling cavity- based on the LAS patent-pending DeltaConcept architecture- this DUV laser provides excellent beam-pointing stability of <2 (mu) rad/ degree(s)C and power stability of <2%. The newest design of the cavity block has adopted a cemented resonator with each component positioned precisely inside a compact monolithic metal block. The automatic and precise crystal shifter ensures long operation lifetime of > 5000 hours of whole 266 nm laser. The microprocessor controlled power supply provides an automatic control of the whole 266 nm laser, making this DUV laser a hands-off system which can meet tough requirements posed by numerous industrial and scientific applications. It will replace the commonplace ion laser as the future DUV laser of choice.

  6. Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis.

    PubMed

    Dai, Xianping; Li, Mengshun; Geng, Feng

    2017-07-01

    Dexamethasone is widely used in multiple myeloma (MM) for its cytotoxic effects on lymphoid cells. However, many MM patients are resistant to dexamethasone, although some can benefit from dexamethasone treatment. In this study, we noted that ω-3 polyunsaturated fatty acids (PUFAs) enhanced the dexamethasone sensitivity of MM cells by inducing cell apoptosis. q-PCR analysis revealed that miR-34a could be significantly induced by PUFAs in U266 and primary MM cells. Transfection with miR-34a antagonist or miR-34a agomir could restore or suppress the dexamethasone sensitivity in U266 cells. Both luciferase reporter assay and Western blot showed that Bcl-2 is the direct target of miR-34a in MM cells. In addition, we observed that PUFAs induced p53 protein expression in MM cells under dexamethasone administration. Furthermore, suppressing p53 by its inhibitor, Pifithrin-α, regulated the miR-34a expression and modulated the sensitivity to dexamethasone in U266 cells. In summary, these results suggest that PUFAs enhance dexamethasone sensitivity to MM cells through the p53/miR-34a axis with a likely contribution of Bcl-2 suppression.

  7. Interferon β induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice.

    PubMed

    Chort, Alice; Alves, Sandro; Marinello, Martina; Dufresnois, Béatrice; Dornbierer, Jean-Gabriel; Tesson, Christelle; Latouche, Morwena; Baker, Darren P; Barkats, Martine; El Hachimi, Khalid H; Ruberg, Merle; Janer, Alexandre; Stevanin, Giovanni; Brice, Alexis; Sittler, Annie

    2013-06-01

    We showed previously, in a cell model of spinocerebellar ataxia 7, that interferon beta induces the expression of PML protein and the formation of PML protein nuclear bodies that degrade mutant ataxin 7, suggesting that the cytokine, used to treat multiple sclerosis, might have therapeutic value in spinocerebellar ataxia 7. We now show that interferon beta also induces PML-dependent clearance of ataxin 7 in a preclinical model, SCA7(266Q/5Q) knock-in mice, and improves motor function. Interestingly, the presence of mutant ataxin 7 in the mice induces itself the expression of endogenous interferon beta and its receptor. Immunohistological studies in brains from two patients with spinocerebellar ataxia 7 confirmed that these modifications are also caused by the disease in humans. Interferon beta, administered intraperitoneally three times a week in the knock-in mice, was internalized with its receptor in Purkinje and other cells and translocated to the nucleus. The treatment induced PML protein expression and the formation of PML protein nuclear bodies and decreased mutant ataxin 7 in neuronal intranuclear inclusions, the hallmark of the disease. No reactive gliosis or other signs of toxicity were observed in the brain or internal organs. The performance of the SCA7(266Q/5Q) knock-in mice was significantly improved on two behavioural tests sensitive to cerebellar function: the Locotronic® Test of locomotor function and the Beam Walking Test of balance, motor coordination and fine movements, which are affected in patients with spinocerebellar ataxia 7. In addition to motor dysfunction, SCA7(266Q/5Q) mice present abnormalities in the retina as in patients: ataxin 7-positive neuronal intranuclear inclusions that were reduced by interferon beta treatment. Finally, since neuronal death does not occur in the cerebellum of SCA7(266Q/5Q) mice, we showed in primary cell cultures expressing mutant ataxin 7 that interferon beta treatment improves Purkinje cell survival.

  8. Exposure of Chlorpromazine to 266 nm Laser Beam Generates New Species with Antibacterial Properties: Contributions to Development of a New Process for Drug Discovery

    PubMed Central

    Pascu, Mihail Lucian; Danko, Balazs; Martins, Ana; Jedlinszki, Nikoletta; Alexandru, Tatiana; Nastasa, Viorel; Boni, Mihai; Militaru, Andra; Andrei, Ionut Relu; Staicu, Angela; Hunyadi, Attila; Fanning, Seamus; Amaral, Leonard

    2013-01-01

    Introduction Phenothiazines when exposed to white light or to UV radiation undergo a variety of reactions that result in degradation of parental compound and formation of new species. This process is slow and may be sped up with exposure to high energy light such as that produced by a laser. Methods Varying concentrations of Chlorpromazine Hydrochloride (CPZ) (2–20 mg/mL in distilled water) were exposed to 266 nm laser beam (time intervals: 1–24 hrs). At distinct intervals the irradiation products were evaluated by spectrophotometry between 200–1500 nm, Thin Layer Chromatography, High Pressure Liquid Chromatography (HPLC) - Diode Array Detection, HPLC tandem mass spectrometry, and for activity against the CPZ sensitive test organism Staphylococcus aureus ATCC 25923. Results CPZ exposure to 266 nm laser beam of given energy levels yielded species, whose number increased with duration of exposure. Although the major species produced were Promazine (PZ), hydroxypromazine or PZ sulfoxide, and CPZ sulfoxide, over 200 compounds were generated with exposure of 20 mg/mL of CPZ for 24 hrs. Evaluation of the irradiation products indicated that the bioactivity against the test organism increased despite the total disappearance of CPZ, that is due, most probably, to one or more new species that remain yet unidentified. Conclusions Exposure of CPZ to a high energy (6.5 mJ) 266 nm laser beam yields rapidly a large number of new and stable species. For biological grade phenothiazines (in other words knowing the impurities in the samples: solvent and solute) this process may be reproducible because one can control within reasonably low experimental errors: the concentration of the parent compound, the laser beam wavelength and average energy, as well as the duration of the exposure time. Because the process is “clean” and rapid, it may offer advantages over the pyrogenically based methods for the production of derivatives. PMID:23405212

  9. Chitayat syndrome: hyperphalangism, characteristic facies, hallux valgus and bronchomalacia results from a recurrent c.266A>G p.(Tyr89Cys) variant in the ERF gene.

    PubMed

    Balasubramanian, M; Lord, H; Levesque, S; Guturu, H; Thuriot, F; Sillon, G; Wenger, A M; Sureka, D L; Lester, T; Johnson, D S; Bowen, J; Calhoun, A R; Viskochil, D H; Bejerano, G; Bernstein, J A; Chitayat, D

    2017-03-01

    In 1993, Chitayat et al. , reported a newborn with hyperphalangism, facial anomalies, and bronchomalacia. We identified three additional families with similar findings. Features include bilateral accessory phalanx resulting in shortened index fingers; hallux valgus; distinctive face; respiratory compromise. To identify the genetic aetiology of Chitayat syndrome and identify a unifying cause for this specific form of hyperphalangism. Through ongoing collaboration, we had collected patients with strikingly-similar phenotype. Trio-based exome sequencing was first performed in Patient 2 through Deciphering Developmental Disorders study. Proband-only exome sequencing had previously been independently performed in Patient 4. Following identification of a candidate gene variant in Patient 2, the same variant was subsequently confirmed from exome data in Patient 4. Sanger sequencing was used to validate this variant in Patients 1, 3; confirm paternal inheritance in Patient 5. A recurrent, novel variant NM_006494.2:c.266A>G p.(Tyr89Cys) in ERF was identified in five affected individuals: de novo (patient 1, 2 and 3) and inherited from an affected father (patient 4 and 5). p.Tyr89Cys is an aromatic polar neutral to polar neutral amino acid substitution, at a highly conserved position and lies within the functionally important ETS-domain of the protein. The recurrent ERF c.266A>C p.(Tyr89Cys) variant causes Chitayat syndrome. ERF variants have previously been associated with complex craniosynostosis. In contrast, none of the patients with the c.266A>G p.(Tyr89Cys) variant have craniosynostosis. We report the molecular aetiology of Chitayat syndrome and discuss potential mechanisms for this distinctive phenotype associated with the p.Tyr89Cys substitution in ERF . Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. ON THE EXPANSION RATE, AGE, AND DISTANCE OF THE SUPERNOVA REMNANT G266.2–1.2 (Vela Jr.)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allen, G. E.; Chow, K.; DeLaney, T.

    An analysis of Chandra ACIS data for two relatively bright and narrow portions of the northwestern rim of G266.2–1.2 (a.k.a. RX J0852.0-4622 or Vela Jr.) reveal evidence of a radial displacement of 2.40 ± 0.56 arcsec between 2003 and 2008. The corresponding expansion rate (0.42 ± 0.10 arcsec yr{sup –1} or 13.6% ± 4.2% kyr{sup –1}) is about half the rate reported for an analysis of XMM-Newton data from a similar, but not identical, portion of the rim over a similar, but not identical, time interval (0.84 ± 0.23 arcsec yr{sup –1}). If the Chandra rate is representative of the remnant as amore » whole, then the results of a hydrodynamic analysis suggest that G266.2–1.2 is between 2.4 and 5.1 kyr old if it is expanding into a uniform ambient medium (whether or not it was produced by a Type Ia or Type II event). If the remnant is expanding into the material shed by a steady stellar wind, then the age could be as much as 50% higher. The Chandra expansion rate and a requirement that the shock speed be greater than or equal to 1000 km s{sup –1} yields a lower limit on the distance of 0.5 kpc. An analysis of previously published distance estimates and constraints suggests G266.2–1.2 is no further than 1.0 kpc. This range of distances is consistent with the distance to the nearer of two groups of material in the Vela Molecular Ridge (0.7 ± 0.2 kpc) and to the Vel OB1 association (0.8 kpc)« less

  11. Photodissociation dynamics of allyl chloride at 200 and 266 nm studied by time-resolved mass spectrometry and photoelectron imaging.

    PubMed

    Shen, Huan; Chen, Jianjun; Hua, Linqiang; Zhang, Bing

    2014-06-26

    The photodissociation dynamics of allyl chloride at 200 and 266 nm has been studied by femtosecond time-resolved mass spectrometry coupled with photoelectron imaging. The molecule was prepared to different excited states by selectively pumping with 400 or 266 nm pulse. The dissociated products were then probed by multiphoton ionization with 800 nm pulse. After absorbing two photons at 400 nm, several dissociation channels were directly observed from the mass spectrum. The two important channels, C-Cl fission and HCl elimination, were found to decay with multiexponential functions. For C-Cl fission, two time constants, 48 ± 1 fs and 85 ± 40 ps, were observed. The first one was due to the fast predissociation process on the repulsive nσ*/πσ* state. The second one could be ascribed to dissociation on the vibrationally excited ground state which is generated after internal conversion from the initially prepared ππ* state. HCl elimination, which is a typical example of a molecular elimination reaction, was found to proceed with two time constants, 600 ± 135 fs and 14 ± 2 ps. We assigned the first one to dissociation on the excited state and the second one to the internal conversion from the ππ* state to the ground state and then dissociation on the ground state. As we excited the molecule with 266 nm light, the transient signals decayed exponentially with a time constant of ∼48 fs, which is coincident with the time scale of C-halogen direct dissociation. Photoelectron images, which provided translational and angular distributions of the generated electron, were also recorded. Detailed analysis of the kinetic energy distribution strongly suggested that C3H4(+) and C3H5(+) were generated from ionization of the neutral radical. The present study reveals the dissociation dynamics of allyl chloride in a time-resolved way.

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rahman, Arman; DeCourcey, Joseph; Larbi, Nadia Ben

    Highlights: •Knock-down of syntaxin-4 in U266 plasma cells resulted in reduction of IgE secretion. •Knock-down of syntaxin-4 also leads to the accumulation of IgE in the cell. •Immuno-fluorescence staining shows co-localisation of IgE and syntaxin-4 in U266 cells. •Findings suggest a critical requirement for syntaxin-4 in IgE secretion from plasma cells. -- Abstract: The humoral immune system provides a crucial first defense against the invasion of microbial pathogens via the secretion of antigen specific immunoglobulins (Ig). The secretion of Ig is carried out by terminally differentiated B-lymphocytes called plasma cells. Despite the key role of plasma cells in the immunemore » response, the mechanisms by which they constitutively traffic large volumes of Ig out of the cell is poorly understood. The involvement of Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in the regulation of protein trafficking from cells has been well documented. Syntaxin-4, a member of the Qa SNARE syntaxin family has been implicated in fusion events at the plasma membrane in a number of cells in the immune system. In this work we show that knock-down of syntaxin-4 in the multiple myeloma U266 human plasma cell line results in a loss of IgE secretion and accumulation of IgE within the cells. Furthermore, we show that IgE co-localises with syntaxin-4 in U266 plasma cells suggesting direct involvement in secretion at the plasma membrane. This study demonstrates that syntaxin-4 plays a critical role in the secretion of IgE from plasma cells and sheds some light on the mechanisms by which these cells constitutively traffic vesicles to the surface for secretion. An understanding of this machinery may be beneficial in identifying potential therapeutic targets in multiple myeloma and autoimmune disease where over-production of Ig leads to severe pathology in patients.« less

  13. [Association of human papillomavirus infection with other microbial pathogens in gynecology].

    PubMed

    Zheng, Mei-yun; Zhao, He-lan; Di, Jun-ping; Lin, Gan; Lin, Ying; Lin, Xi; Zheng, Min-qiao

    2010-06-01

    To Investigate correlation between screening assay of human papillomavirus (HPV) and microbial pathogens in gynecology. Cervical samples were collected to search for HPV, bacteria and yeast infections in gynecologic outpatients. HPV typing was carried out by PCR and sequencing on cervical brush specimens. Chlamydia trachomatis was identified by strand displacement amplification (SDA) and the other microorganisms were detected by conventional methods. All data were analyzed to investigate the correlation among them. In this cross-sectional study, among 857 enrolled outpatients, there were 266 cases with positive HPV DNA, and the rate of infection was 31.0% (266/857). HPV genotype showed that thirty-five different HPV types were identified, of which HPV16 was the most prevalent (14.5%, 38/262), followed by HPV58 (9.2%, 24/262), HPV53 (8.0%, 21/262) and HPV42 (6.1%, 16/262); while other genotypes were present in less than 5% of HPV positive women. According to the reclassification, the aggregated percentage (high-risk and probably high-risk) of detected HPV was 58.8% (154/262), 27.9% (73/262) for low-risk and 13.4% (35/262) for unknown-risk HPV types. Among HPV positive women, cervical brush specimens results showed that more than 60% cases with normal cytology, 3.8% (10/266) with high-grade squamous intraepithelial lesions (HSIL), 29.7% (79/266) with low-grade squamous intraepithelial lesions (LSIL) and 3.0% (8/266) with atypical squamous cells of undetermined significance (ASCUS), respectively. Statistical analyses revealed there was a significant association between the infected HPV and Chlamydia trachomatis or Ureaplasma urealyticum (> 10,000 CCU/ml; all P < 0.01), while no correlation was found between HPV infection and bacterial vaginosis, streptococcus agalactiae, candida, Trichomonas vaginalis or Ureaplasma urealyticum (≤ 10 000 CCU/ml; all P > 0.05). Among the cases with bacterial vaginosis, the positive rate of HPV infected was 42.6%. Chlamydia trachomatis was one of the high-risk factors for the infection of HPV (OR = 2.82, 95% CI: 1.74 - 4.57). Mycoplasma hominis was isolated only in 2 cases, no patient was infected with Neisseria gonorrhoeae. Although bacterial vaginosis was not significantly associated with HPV, it was more common among the HPV positive women. There is the significant association between HPV and Chlamydia trachomatis or Ureaplasma urealyticum which may be increase the infection of HPV. These data suggest that it may be important to screen for the simultaneous presence of different microorganisms which may have synergistic pathological effects.

  14. 24 CFR 266.405 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Mortgage and Closing...

  15. Measurement of neutron energy spectra for Eg=23.1 and 26.6 MeV mono-energetic photon induced reaction on natC using laser electron photon beam at NewSUBARU

    NASA Astrophysics Data System (ADS)

    Itoga, Toshiro; Nakashima, Hiroshi; Sanami, Toshiya; Namito, Yoshihito; Kirihara, Yoichi; Miyamoto, Shuji; Takemoto, Akinori; Yamaguchi, Masashi; Asano, Yoshihiro

    2017-09-01

    Photo-neutron energy spectra for Eg=23.1 and 26.6 MeV mono-energetic photons on natC were measured using laser Compton scattering facility at NewSUBARU BL01. The photon energy spectra were evaluated through measurements and simulations with collimator sizes and arrangements for the laser electron photon. The neutron energy spectra for the natC(g,xn) reaction were measured at 60 degrees in horizontal and 90 degrees in horizontal and vertical with respect to incident photon. The spectra show almost isotropic angular distribution and flat energy distribution from detection threshold to upper limit defined by reaction Q-value.

  16. Ada Compiler Validation Summary Report: Certificate Number: 940325S1. 11352 DDC-I DACS Sun SPARC/Solaries to Pentium PM Bare Ada Cross Compiler System, Version 4.6.4 Sun SPARCclassic = Intel Pentium (Operated as Bare Machine) Based in Xpress Desktop (Intel Product Number: XBASE6E4F-B)

    DTIC Science & Technology

    1994-03-25

    Technology Building 225, Room A266 Gait•--eburg, Maryland 20899 U.S.A. Ada Von Ogan~ztionAda Jointt Program Office De & Software David R . Basel...Standards and Technology Building 225, Room A266 Gaithersburg, Maryland 20899 U.S.A. azi Ada Joint Program office Directoz’,’Coputer & Softvare David R ...characters, a bar (" r ) is written in the 16th position and the rest of the characters ame not prined. "* The place of the definition, i.e.. a line

  17. Comparative In Vitro Activities of XRP 2868, Pristinamycin, Quinupristin-Dalfopristin, Vancomycin, Daptomycin, Linezolid, Clarithromycin, Telithromycin, Clindamycin, and Ampicillin against Anaerobic Gram-Positive Species, Actinomycetes, and Lactobacilli

    PubMed Central

    Goldstein, Ellie J. C.; Citron, Diane M.; Merriam, C. Vreni; Warren, Yumi A.; Tyrrell, Kerin L.; Fernandez, Helen T.; Bryskier, Andre

    2005-01-01

    A comparative study of the in vitro activities of XRP 2868, a new oral streptogramin, against 266 anaerobic gram-positive clinical isolates using the agar dilution method showed that the XRP 2868 MICs for 95% (254 of 266) of isolates were ≤0.5 μg/ml. XRP 2868 MICs for only two strains, one being Clostridium clostridioforme (MIC, 16 μg/ml) and the other being Clostridium difficile (MIC, 32 μg/ml), were >2 μg/ml. Depending on its pharmacokinetics and pharmacodynamics, XRP 2868 has potential for use against infections with gram-positive anaerobes and deserves further clinical evaluation. PMID:15616322

  18. 27 CFR 24.266 - Inventory losses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

  19. 27 CFR 24.266 - Inventory losses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

  20. 27 CFR 24.266 - Inventory losses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

  1. 27 CFR 24.266 - Inventory losses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

  2. 12 CFR 266.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... dealings with the public. (c) Appear personally includes personal appearance or attendance before, or... requests for general information or explanations of Board policy or interpretation shall not be construed...

  3. 49 CFR 266.5 - State eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... methodology for determining the ratio of benefits to costs of projects for which acquisition assistance... maintain adequate programs of investigation, research, promotion, and development with provision for public...

  4. Stability-indicating validation of acitretin and isoacitretin in human plasma by LC-ESI-MS/MS bioanalytical method and its application to pharmacokinetic analysis.

    PubMed

    Kumar, Ajay; Monif, Tausif; Khuroo, Arshad; Sasmal, Dinakar; Goswami, Dipanjan; Lahkar, Vijay Kumar

    2011-06-01

    LC- ESI- MS/MS simultaneous bioanalytical method was developed to determine acitretin and its metabolite isoacitretin in human plasma using acitretin-d3 used as the internal standard for both analytes. The compounds were extracted using protein precipitation coupled with liquid-liquid extraction with flash freezing technique. Negative mass transitions (m/z) of acitretin, isoacitretin and acitretin-d3 were detected in multiple reactions monitoring (MRM) mode at 325.4 → 266.3, 325.2 → 266.1 and 328.3 → 266.3, respectively, with a turbo ion spray interface. The chromatographic separation was achieved on an Ascentis-RP amide column (4.6 × 150 mm, 5 µm) with mobile phase delivered in isocratic mode. The method was validated over a concentration range of 1.025-753.217 ng/mL for acitretin and 0.394-289.234 ng/mL for isoacitretin with a limit of quantification of 1.025 and 0.394 ng/mL. The intra-day and inter-day precisions were below 8.1% for acitretin and below 13.8% for isoacitretin, while accuracy was within ±7.0 and ±10.6% respectively. For the first time, the best possible conditions for plasma stability of acitretin and isoacitretin are presented and discussed with application to clinical samples. Copyright © 2010 John Wiley & Sons, Ltd.

  5. Multi-color autofluorescence and scattering spectroscopy provides rapid assessment of kidney function following ischemic injury

    NASA Astrophysics Data System (ADS)

    Raman, Rajesh N.; Pivetti, Chris D.; Ramsamooj, Rajendra; Troppmann, Christoph; Demos, Stavros G.

    2018-02-01

    A major source of kidneys for transplant comes from deceased donors whose tissues have suffered an unknown amount of warm ischemia prior to retrieval, with no quantitative means to assess function before transplant. Toward addressing this need, non-contact monitoring of optical signatures in rat kidneys was performed in vivo during ischemia and reperfusion. Kidney autofluorescence images were captured under ultraviolet illumination (355 nm, 325 nm, and 266 nm) in order to provide information on related metabolic and non-metabolic response. In addition, light scattering images under 355 nm, 325 nm, and 266 nm, 500 nm illumination were monitored to report on changes in kidney optical properties giving rise to the observed autofluorescence signals during these processes. During reperfusion, various signal ratios were generated from the recorded signals and then parametrized. Time-dependent parameters derived from the ratio of autofluorescence under 355 nm excitation to that under 266 nm excitation, as well as from 500 nm scattered signal, were found capable of discriminating dysfunctional kidneys from those that were functional (p < 0.01) within hours of reperfusion. Kidney dysfunction was confirmed by subsequent survival study and histology following autopsy up to a week later. Physiologic changes potentially giving rise to the observed signals, including those in cellular metabolism, vascular response, tissue microstructure, and microenvironment chemistry, are discussed.

  6. 49 CFR 266.17 - Applications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... submitted by the designated State agency using the standard forms contained in Attachment M of Office of... plans for agricultural development or existence of fossil fuel reserves, the State's anticipated...

  7. 49 CFR 266.17 - Applications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... submitted by the designated State agency using the standard forms contained in Attachment M of Office of... plans for agricultural development or existence of fossil fuel reserves, the State's anticipated...

  8. 49 CFR 266.17 - Applications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... submitted by the designated State agency using the standard forms contained in Attachment M of Office of... plans for agricultural development or existence of fossil fuel reserves, the State's anticipated...

  9. 49 CFR 266.17 - Applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... submitted by the designated State agency using the standard forms contained in Attachment M of Office of... plans for agricultural development or existence of fossil fuel reserves, the State's anticipated...

  10. 49 CFR 266.17 - Applications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... submitted by the designated State agency using the standard forms contained in Attachment M of Office of... plans for agricultural development or existence of fossil fuel reserves, the State's anticipated...

  11. 39 CFR 266.9 - Exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and evaluative purposes, it is impossible to determine in advance what information might be of... Records, USPS 100.300; Personnel Research Records, 100.600; and Emergency Management Records, USPS 500.300...

  12. 39 CFR 266.9 - Exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and evaluative purposes, it is impossible to determine in advance what information might be of... Records, USPS 100.300; Personnel Research Records, 100.600; and Emergency Management Records, USPS 500.300...

  13. 39 CFR 266.9 - Exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and evaluative purposes, it is impossible to determine in advance what information might be of... Records, USPS 100.300; Personnel Research Records, 100.600; and Emergency Management Records, USPS 500.300...

  14. 39 CFR 266.9 - Exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and evaluative purposes, it is impossible to determine in advance what information might be of... Records, USPS 100.300; Personnel Research Records, 100.600; and Emergency Management Records, USPS 500.300...

  15. 39 CFR 266.9 - Exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and evaluative purposes, it is impossible to determine in advance what information might be of... Records, USPS 100.300; Personnel Research Records, 100.600; and Emergency Management Records, USPS 500.300...

  16. First chemical separation and identification of Seaborgium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tuerler, A.; Eichler, B.; Jost, D.T.

    1997-12-31

    The chemical properties of element 106 (Seaborgium, Sg) were successfully studied using the On-line Gas Chromatography Apparatus (OLGA III). After chemical separation of Sg in the form of volatile oxichlorides the nuclides {sup 265}Sg and {sup 266}Sg were unambiguously identified and their half-lives were determined for the first time. The Sg nuclides were produced from the {sup 248}Cm({sup 22}Ne, 4,5n){sup 266,265}Sg reaction at the GSI Darmstadt UNILAC accelerator. Simultaneously, short-lived W nuclides were produced from a small admixture of {sup 152}Gd to the Cm target material. As predicted by relativistic calculations and by extrapolations of chemical properties, it was demonstratedmore » that Sg oxichlorides are indeed less volatile than their lighter homologue W- and Mo-oxichlorides.« less

  17. 40 CFR 266.20 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... contain. (c) Anti-skid/deicing uses of slags, which are generated from high temperature metals recovery...) Fertilizers that contain recyclable materials are not subject to regulation provided that: (1) They are zinc...

  18. 40 CFR 266.20 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... contain. (c) Anti-skid/deicing uses of slags, which are generated from high temperature metals recovery...) Fertilizers that contain recyclable materials are not subject to regulation provided that: (1) They are zinc...

  19. 40 CFR 266.345 - Whom must you notify?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FACILITIES Conditional Exemption for Low-Level Mixed Waste Storage, Treatment, Transportation and Disposal....340 prior to disposal in order for the waste to remain exempt under the transportation and disposal...

  20. 49 CFR 266.19 - Environmental impact.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... will not: use 4(f)-protected properties; adversely affect properties under section 106 of the National... shall: (A) Prepare an environmental assessment to determine whether the future use of the property will...

  1. 49 CFR 266.19 - Environmental impact.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... will not: use 4(f)-protected properties; adversely affect properties under section 106 of the National... shall: (A) Prepare an environmental assessment to determine whether the future use of the property will...

  2. 49 CFR 266.19 - Environmental impact.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... will not: use 4(f)-protected properties; adversely affect properties under section 106 of the National... shall: (A) Prepare an environmental assessment to determine whether the future use of the property will...

  3. Survey of basic medical researchers on the awareness of animal experimental designs and reporting standards in China.

    PubMed

    Ma, Bin; Xu, Jia-Ke; Wu, Wen-Jing; Liu, Hong-Yan; Kou, Cheng-Kun; Liu, Na; Zhao, Lulu

    2017-01-01

    To investigate the awareness and use of the Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE) risk-of-bias tool, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) reporting guidelines, and Gold Standard Publication Checklist (GSPC) in China in basic medical researchers of animal experimental studies. A national questionnaire-based survey targeting basic medical researchers was carried in China to investigate the basic information and awareness of SYRCLE's risk of bias tool, ARRIVE guidelines, GSPC, and animal experimental bias risk control factors. The EpiData3.1 software was used for data entry, and Microsoft Excel 2013 was used for statistical analysis in this study. The number of cases (n) and percentage (%) of classified information were statistically described, and the comparison between groups (i.e., current students vs. research staff) was performed using chi-square test. A total of 298 questionnaires were distributed, and 272 responses were received, which included 266 valid questionnaires (from 118 current students and 148 research staff). Among the 266 survey participants, only 15.8% was aware of the SYRCLE's risk of bias tool, with significant difference between the two groups (P = 0.003), and the awareness rates of ARRIVE guidelines and GSPC were only 9.4% and 9.0%, respectively; 58.6% survey participants believed that the reports of animal experimental studies in Chinese literature were inadequate, with significant difference between the two groups (P = 0.004). In addition, only approximately 1/3 of the survey participants had read systematic reviews and meta-analysis reports of animal experimental studies; only 16/266 (6.0%) had carried out/participated in and 11/266 (4.1%) had published systematic reviews/meta-analysis of animal experimental studies. The awareness and use rates of SYRCLE's risk-of-bias tool, the ARRIVE guidelines, and the GSPC were low among Chinese basic medical researchers. Therefore, specific measures are necessary to promote and popularize these standards and specifications and to introduce these standards into guidelines of Chinese domestic journals as soon as possible to raise awareness and increase use rates of researchers and journal editors, thereby improving the quality of animal experimental methods and reports.

  4. 7 CFR 1944.266 - Other Federal requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...—Recipients must maintain current data on the race, ethnicity and gender of program applicants and... Federal Register Notice published on January 16, 1992, at 57 FR 1942. (d) Nondiscrimination and equal...

  5. 40 CFR 270.32 - Establishing permit conditions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... terms and conditions as the Administrator or State Director determines necessary to protect human health... 63, subpart EEE, 264 or 266 to ensure protection of human health and the environment, he shall...

  6. 40 CFR 270.32 - Establishing permit conditions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... terms and conditions as the Administrator or State Director determines necessary to protect human health... 63, subpart EEE, 264 or 266 to ensure protection of human health and the environment, he shall...

  7. 24 CFR 266.300 - HFAs accepting 50 percent or more of risk.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... is responsible for the performance of all functions except those HUD-retained functions specified in... advances of mortgage proceeds during construction, review and approval of cost certification, and closing...

  8. 24 CFR 266.628 - Initial claim payments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract... as of the date of default, plus interest at the mortgage note rate from date of default to date of...

  9. 7 CFR 1944.266 - Other Federal requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... exercised any function or responsibilities with respect to activities assisted with CHSP grant funds, or who is in a position to participate in a decision-making process or gain inside information with regard...

  10. 7 CFR 1944.266 - Other Federal requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... exercised any function or responsibilities with respect to activities assisted with CHSP grant funds, or who is in a position to participate in a decision-making process or gain inside information with regard...

  11. 7 CFR 1944.266 - Other Federal requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... exercised any function or responsibilities with respect to activities assisted with CHSP grant funds, or who is in a position to participate in a decision-making process or gain inside information with regard...

  12. 7 CFR 1944.266 - Other Federal requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... exercised any function or responsibilities with respect to activities assisted with CHSP grant funds, or who is in a position to participate in a decision-making process or gain inside information with regard...

  13. UV holographic filters

    NASA Astrophysics Data System (ADS)

    Kalyashova, Zoya N.

    2017-11-01

    A new approach to UV holographic filter's manufacturing, when the filters are the volume reflection holograms, working in UV region in the second Bragg diffraction order, is offered. The method is experimentally realized for wavelength of 266 nm.

  14. 32 CFR 634.54 - List of State Driver's License Agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Vehicles, 1800 Washington Street, East, Charleston, WV 25317, (304) 348-2719. Wisconsin: Department of Transportation Reciprocity and Permits, P.O. Box 7908, Madison, WI 53707, (608) 266-2585. Wyoming: Department of...

  15. 32 CFR 634.54 - List of State Driver's License Agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Vehicles, 1800 Washington Street, East, Charleston, WV 25317, (304) 348-2719. Wisconsin: Department of Transportation Reciprocity and Permits, P.O. Box 7908, Madison, WI 53707, (608) 266-2585. Wyoming: Department of...

  16. 32 CFR 634.54 - List of State Driver's License Agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Vehicles, 1800 Washington Street, East, Charleston, WV 25317, (304) 348-2719. Wisconsin: Department of Transportation Reciprocity and Permits, P.O. Box 7908, Madison, WI 53707, (608) 266-2585. Wyoming: Department of...

  17. 32 CFR 634.54 - List of State Driver's License Agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Vehicles, 1800 Washington Street, East, Charleston, WV 25317, (304) 348-2719. Wisconsin: Department of Transportation Reciprocity and Permits, P.O. Box 7908, Madison, WI 53707, (608) 266-2585. Wyoming: Department of...

  18. 24 CFR 266.650 - Items deducted from total loss.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... not limited to returned premiums from canceled insurance policies, interest on investments of reserve...) Any net income from the mortgaged property/project that the HFA received after the date of default. (e...

  19. A laser-based FAIMS detector for detection of ultra-low concentrations of explosives

    NASA Astrophysics Data System (ADS)

    Akmalov, Artem E.; Chistyakov, Alexander A.; Kotkovskii, Gennadii E.; Sychev, Alexey V.; Tugaenko, Anton V.; Bogdanov, Artem S.; Perederiy, Anatoly N.; Spitsyn, Eugene M.

    2014-06-01

    A non-contact method for analyzing of explosives traces from surfaces was developed. The method is based on the laser desorption of analyzed molecules from the surveyed surfaces followed by the laser ionization of air sample combined with the field asymmetric ion mobility spectrometry (FAIMS). The pulsed radiation of the fourth harmonic of a portable GSGG: Cr3+ :Nd3+ laser (λ = 266 nm) is used. The laser desorption FAIMS analyzer have been developed. The detection limit of the analyzer equals 40 pg for TNT. The results of detection of trinitrotoluene (TNT), cyclotrimethylenetrinitramine (RDX) and cyclotetramethylenetetranitramine (HMX) are presented. It is shown that laser desorption of nitro-compounds from metals is accompanied by their surface decomposition. A method for detecting and analyzing of small concentrations of explosives in air based on the laser ionization and the FAIMS was developed. The method includes a highly efficient multipass optical scheme of the intracavity fourthharmonic generation of pulsed laser radiation (λ = 266 nm) and the field asymmetric ion mobility (FAIM) spectrometer disposed within a resonator. The ions formation and detection proceed inside a resonant cavity. The laser ion source based on the multi-passage of radiation at λ = 266 nm through the ionization region was elaborated. On the basis of the method the laser FAIMS analyzer has been created. The analyzer provides efficient detection of low concentrations of nitro-compounds in air and shows a detection limit of 10-14 - 10-15 g/cm3 both for RDX and TNT.

  20. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells

    PubMed Central

    Jang, Jinsil; Jeong, Soo-Jin; Kwon, Hee-Young; Jung, Ji Hoon; Sohn, Eun Jung; Lee, Hyo-Jung; Kim, Ji-Hyun; Kim, Sun-Hee; Kim, Jin Hyoung; Kim, Sung-Hoon

    2013-01-01

    Background. Combination cancer therapy is one of the attractive approaches to overcome drug resistance of cancer cells. In the present study, we investigated the synergistic effect of decursin from Angelica gigas and doxorubicin on the induction of apoptosis in three human multiple myeloma cells. Methodology/Principal Findings. Combined treatment of decursin and doxorubicin significantly exerted significant cytotoxicity compared to doxorubicin or decursin in U266, RPMI8226, and MM.1S cells. Furthermore, the combination treatment enhanced the activation of caspase-9 and -3, the cleavage of PARP, and the sub G1 population compared to either drug alone in three multiple myeloma cells. In addition, the combined treatment downregulated the phosphorylation of mTOR and its downstream S6K1 and activated the phosphorylation of ERK in three multiple myeloma cells. Furthermore, the combined treatment reduced mitochondrial membrane potential, suppressed the phosphorylation of JAK2, STAT3, and Src, activated SHP-2, and attenuated the expression of cyclind-D1 and survivin in U266 cells. Conversely, tyrosine phosphatase inhibitor pervanadate reversed STAT3 inactivation and also PARP cleavage and caspase-3 activation induced by combined treatment of doxorubicin and decursin in U266 cells. Conclusions/Significance. Overall, the combination treatment of decursin and doxorubicin can enhance apoptotic activity via mTOR and/or STAT3 signaling pathway in multiple myeloma cells. PMID:23818927

  1. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells.

    PubMed

    Jang, Jinsil; Jeong, Soo-Jin; Kwon, Hee-Young; Jung, Ji Hoon; Sohn, Eun Jung; Lee, Hyo-Jung; Kim, Ji-Hyun; Kim, Sun-Hee; Kim, Jin Hyoung; Kim, Sung-Hoon

    2013-01-01

    Background. Combination cancer therapy is one of the attractive approaches to overcome drug resistance of cancer cells. In the present study, we investigated the synergistic effect of decursin from Angelica gigas and doxorubicin on the induction of apoptosis in three human multiple myeloma cells. Methodology/Principal Findings. Combined treatment of decursin and doxorubicin significantly exerted significant cytotoxicity compared to doxorubicin or decursin in U266, RPMI8226, and MM.1S cells. Furthermore, the combination treatment enhanced the activation of caspase-9 and -3, the cleavage of PARP, and the sub G1 population compared to either drug alone in three multiple myeloma cells. In addition, the combined treatment downregulated the phosphorylation of mTOR and its downstream S6K1 and activated the phosphorylation of ERK in three multiple myeloma cells. Furthermore, the combined treatment reduced mitochondrial membrane potential, suppressed the phosphorylation of JAK2, STAT3, and Src, activated SHP-2, and attenuated the expression of cyclind-D1 and survivin in U266 cells. Conversely, tyrosine phosphatase inhibitor pervanadate reversed STAT3 inactivation and also PARP cleavage and caspase-3 activation induced by combined treatment of doxorubicin and decursin in U266 cells. Conclusions/Significance. Overall, the combination treatment of decursin and doxorubicin can enhance apoptotic activity via mTOR and/or STAT3 signaling pathway in multiple myeloma cells.

  2. Medical Efforts and Injury Patterns of Military Hospital Patients Following the 2013 Lushan Earthquake in China: A Retrospective Study

    PubMed Central

    Kang, Peng; Tang, Bihan; Liu, Yuan; Liu, Xu; Liu, Zhipeng; Lv, Yipeng; Zhang, Lulu

    2015-01-01

    The aim of this paper is to investigate medical efforts and injury profiles of victims of the Lushan earthquake admitted to three military hospitals. This study retrospectively investigated the clinical records of 266 admitted patients evacuated from the Lushan earthquake area. The 2005 version of the Abbreviated Injury Scale (AIS-2005) was used to identify the severity of each injury. Patient demographic data, complaints, diagnoses, injury types, prognosis, means of transportation, and cause of injury were all reviewed individually. The statistical analysis of the study was conducted primarily using descriptive statistics. Of the 266 patients, 213 (80.1%) were admitted in the first two days. A total of 521 injury diagnoses were recorded in 266 patients. Earthquake-related injuries were primarily caused by buildings collapsing (38.4%) and victims being struck by objects (33.8%); the most frequently injured anatomic sites were the lower extremities and pelvis (34.2%) and surface area of the body (17.9%). Fracture (41.5%) was the most frequent injury, followed by soft tissue injury (27.5%), but crush syndrome was relatively low (1.2%) due to the special housing structures in the Lushan area. The most commonly used procedure was suture and dressings (33.7%), followed by open reduction and internal fixation (21.9%).The results of this study help formulate recommendations to improve future disaster relief and emergency planning in remote, isolated, and rural regions of developing countries. PMID:26334286

  3. Medical Efforts and Injury Patterns of Military Hospital Patients Following the 2013 Lushan Earthquake in China: A Retrospective Study.

    PubMed

    Kang, Peng; Tang, Bihan; Liu, Yuan; Liu, Xu; Liu, Zhipeng; Lv, Yipeng; Zhang, Lulu

    2015-08-31

    The aim of this paper is to investigate medical efforts and injury profiles of victims of the Lushan earthquake admitted to three military hospitals. This study retrospectively investigated the clinical records of 266 admitted patients evacuated from the Lushan earthquake area. The 2005 version of the Abbreviated Injury Scale (AIS-2005) was used to identify the severity of each injury. Patient demographic data, complaints, diagnoses, injury types, prognosis, means of transportation, and cause of injury were all reviewed individually. The statistical analysis of the study was conducted primarily using descriptive statistics. Of the 266 patients, 213 (80.1%) were admitted in the first two days. A total of 521 injury diagnoses were recorded in 266 patients. Earthquake-related injuries were primarily caused by buildings collapsing (38.4%) and victims being struck by objects (33.8%); the most frequently injured anatomic sites were the lower extremities and pelvis (34.2%) and surface area of the body (17.9%). Fracture (41.5%) was the most frequent injury, followed by soft tissue injury (27.5%), but crush syndrome was relatively low (1.2%) due to the special housing structures in the Lushan area. The most commonly used procedure was suture and dressings (33.7%), followed by open reduction and internal fixation (21.9%).The results of this study help formulate recommendations to improve future disaster relief and emergency planning in remote, isolated, and rural regions of developing countries.

  4. Depth profiling of galvanoaluminium-nickel coatings on steel by UV- and VIS-LIBS

    NASA Astrophysics Data System (ADS)

    Nagy, T. O.; Pacher, U.; Giesriegl, A.; Weimerskirch, M. J. J.; Kautek, W.

    2017-10-01

    Laser-induced depth profiling was applied to the investigation of galvanised steel sheets as a typical modern multi-layer coating system for environmental corrosion protection. The samples were ablated stepwise by the use of two different wavelengths of a frequency-converted Nd:YAG-laser, 266 nm and 532 nm, with a pulse duration of τ = 4 ns at fluences ranging from F = 50 to 250 J cm-2. The emission light of the resulting plasma was analysed as a function of both penetration depth and elemental spectrum in terms of linear correlation analysis. Elemental depth profiles were calculated and compared to EDX-cross sections of the cut sample. A proven mathematical algorithm designed for the reconstruction of layer structures from distorted emission traces caused by the Gaussian ablation profile can even resolve thin intermediate layers in terms of depth and thickness. The obtained results were compared to a purely thermally controlled ablation model. Thereby light-plasma coupling is suggested to be a possible cause of deviations in the ablation behaviour of Al. The average ablation rate h as a function of fluence F for Ni ranges from 1 to 3.5 μm/pulse for λ = 266 nm as well as for λ = 532 nm. In contrast, the range of h for Al differs from 2 to 4 μm/pulse for λ = 532 nm and 4 to 8 μm/pulse for λ = 266 nm in the exact same fluence range on the exact same sample.

  5. 27 CFR 20.266 - Time for making entries in records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM Records and... permittee's normal accounting cycle if (a) supporting or supplemental records are prepared at the time of...

  6. 24 CFR 266.642 - Appraisals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the effect of the recovery of less than the face amount of the HFA Debenture held by HUD, an appraisal... the HFA files an application for final claim settlement. If at the time of final claim settlement the...

  7. 20 CFR 266.7 - Accountability of a representative payee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Administration within the past 15 years or whether any such charges are pending. (b) An individual to whom... make accounting reports. The Board may ask the following questions: (1) The amount of benefit payments...

  8. 20 CFR 266.4 - Information considered in selecting a representative payee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., including the type of relationship, e.g., family or legal guardianship; degree of relationship, if the... payee unless such appointment poses no substantial conflict of interest and unless the creditor is: (1...

  9. 49 CFR 266.23 - Record, audit, and examination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... accounting of all program funds, and for any longer period necessary to resolve audit findings, have access for the purpose of audit and examination to any books, documents, papers, and records which in the...

  10. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... rejected weld. (b) The amount, location; and cover of each size of pipe installed. (c) The location of each... overhead crossing. (f) The location of each valve and corrosion test station. [Amdt. 195-22, 46 FR 38360...

  11. National Hurricane Research Initiative Act of 2011

    THOMAS, 112th Congress

    Sen. Nelson, Bill [D-FL

    2011-03-30

    Senate - 01/02/2013 By Senator Rockefeller from Committee on Commerce, Science, and Transportation filed written report. Report No. 112-266. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  12. 31 CFR 348.0 - Offering of securities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the Treasury designated under federal law (including, but not limited to: 12 U.S.C. 90, 265-266, 1464(k), and 1789a; 31 U.S.C. 3303) which have executed a Depositary, Financial Agency, and Collateral...

  13. 31 CFR 348.0 - Offering of securities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of the Treasury designated under federal law (including, but not limited to: 12 U.S.C. 90, 265-266, 1464(k), and 1789a; 31 U.S.C. 3303) which have executed a Depositary, Financial Agency, and Collateral...

  14. 31 CFR 348.0 - Offering of securities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of the Treasury designated under federal law (including, but not limited to: 12 U.S.C. 90, 265-266, 1464(k), and 1789a; 31 U.S.C. 3303) which have executed a Depositary, Financial Agency, and Collateral...

  15. 31 CFR 348.0 - Offering of securities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the Treasury designated under federal law (including, but not limited to: 12 U.S.C. 90, 265-266, 1464(k), and 1789a; 31 U.S.C. 3303) which have executed a Depositary, Financial Agency, and Collateral...

  16. 24 CFR 266.220 - Nondiscrimination in housing and employment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... selection procedures that discriminate against families with children, except in the case of a project that.... 3607(b)(2)); (b) Not discriminate against any family because of the sex of the head of household; (c...

  17. 24 CFR 266.220 - Nondiscrimination in housing and employment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... selection procedures that discriminate against families with children, except in the case of a project that.... 3607(b)(2)); (b) Not discriminate against any family because of the sex of the head of household; (c...

  18. 7. DETAIL VIEW OF FIGUEROA STREET VIADUCT. SAME CAMERA POSITION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. DETAIL VIEW OF FIGUEROA STREET VIADUCT. SAME CAMERA POSITION AS CA-265-J-8. LOOKING 266°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  19. Lightcurves of nine asteroids, with pole and sense of rotation of 42 Isis

    NASA Astrophysics Data System (ADS)

    Denchev, P.; Magnusson, P.; Donchev, Z.

    1998-02-01

    The results of photometric observations of 9 asteroids collected from 1991 to 1997 are presented. The observations have been conducted at Belogradchik and Rozhen observatories, Bulgaria. For 42 Isis a spin pole determination has been performed: we derive a retrograde sense of rotation, a sidereal period of 0.5665417 ± 0.0000005 days and two solutions for the spin vector: ( P1: λ0 = 288° ± 5°, β0 = -16° ± 2°; P2: λ0 = 117° ± 8°, β0 = -5° ± 4°). The rotational period of 266 Aline is estimated to be 12.3±0.1 h. Composite lightcurves have been obtained for four objects (21 Lutetia, 24 Themis, 42 Isis and 266 Aline). Other lightcurves have been obtained for the asteroids 27 Euterpe, 38 Leda, 70 Panopaea, 173 Ino and 218 Bianca.

  20. Imaging charge transfer in a cation-π system: velocity-map imaging of Ag(+)(benzene) photodissociation.

    PubMed

    Maner, Jonathon A; Mauney, Daniel T; Duncan, Michael A

    2015-11-19

    Ag(+)(benzene) complexes are generated in the gas phase by laser vaporization and mass selected in a time-of-flight spectrometer. UV laser excitation at either 355 or 266 nm results in dissociative charge transfer (DCT), leading to neutral silver atom and benzene cation products. Kinetic energy release in translationally hot benzene cations is detected using a new instrument designed for photofragment imaging of mass-selected ions. Velocity-map imaging and slice imaging techniques are employed. In addition to the expected translational energy release, DCT of Ag(+)(benzene) produces a distribution of internally hot benzene cations. Compared with experiments at 355 nm, 266 nm excitation produces only slightly higher translational excitation and a much greater fraction of internally hot benzene ions. The maximum kinetic energy release in the photodissociation sets an upper limit on the Ag(+)(benzene) dissociation energy of 32.8 (+1.4/-1.5) kcal/mol.

  1. Visual Circular Analysis of 266 Years of Sunspot Counts.

    PubMed

    Buelens, Bart

    2016-06-01

    Sunspots, colder areas that are visible as dark spots on the surface of the Sun, have been observed for centuries. Their number varies with a period of ∼11 years, a phenomenon closely related to the solar activity cycle. Recently, observation records dating back to 1749 have been reassessed, resulting in the release of a time series of sunspot numbers covering 266 years of observations. This series is analyzed using circular analysis to determine the periodicity of the occurrence of solar maxima. The circular analysis is combined with spiral graphs to provide a single visualization, simultaneously showing the periodicity of the series, the degree to which individual cycle lengths deviate from the average period, and differences in levels reached during the different maxima. This type of visualization of cyclic time series with varying cycle lengths in which significant events occur periodically is broadly applicable. It is aimed particularly at science communication, education, and public outreach.

  2. Ballistosporomyces changbaiensis sp. nov. and Ballistosporomyces bomiensis sp. nov., two novel species isolated from shrub plant leaves.

    PubMed

    Han, Pei-Jie; Li, Ai-Hua; Wang, Qi-Ming; Bai, Feng-Yan

    2016-07-01

    Four strains, CB 266(T), CB 272, XZ 44D1(T) and XZ 49D2, isolated from shrub plant leaves in China were identified as two novel species of the genus Ballistosporomyces by the sequence analysis of the small subunit of ribosomal RNA (SSU rRNA), the D1/D2 domains of the large subunit of rRNA (LSU rRNA) and internal transcribed spacer (ITS) + 5.8S rRNA region, and physiological comparisons. Ballistosporomyces changbaiensis sp. nov. (type strain CB 266(T) = CGMCC 2.02298(T) = CBS 10124(T), Mycobank number MB 815700) and Ballistosporomyces bomiensis sp. nov. (type strain XZ 44D1(T) = CGMCC 2.02661(T) = CBS 12512(T), Mycobank number MB 815701) are proposed to accommodate these two new species.

  3. Using UVC Light-Emitting Diodes at Wavelengths of 266 to 279 Nanometers To Inactivate Foodborne Pathogens and Pasteurize Sliced Cheese

    PubMed Central

    Kim, Soo-Ji; Kim, Do-Kyun

    2015-01-01

    UVC light is a widely used sterilization technology. However, UV lamps have several limitations, including low activity at refrigeration temperatures, a long warm-up time, and risk of mercury exposure. UV-type lamps only emit light at 254 nm, so as an alternative, UV light-emitting diodes (UV-LEDs) which can produce the desired wavelengths have been developed. In this study, we validated the inactivation efficacy of UV-LEDs by wavelength and compared the results to those of conventional UV lamps. Selective media inoculated with Escherichia coli O157:H7, Salmonella enterica serovar Typhimurium, and Listeria monocytogenes were irradiated using UV-LEDs at 266, 270, 275, and 279 nm in the UVC spectrum at 0.1, 0.2, 0.5, and 0.7 mJ/cm2, respectively. The radiation intensity of the UV-LEDs was about 4 μW/cm2, and UV lamps were covered with polypropylene films to adjust the light intensity similar to those of UV-LEDs. In addition, we applied UV-LED to sliced cheese at doses of 1, 2, and 3 mJ/cm2. Our results showed that inactivation rates after UV-LED treatment were significantly different (P < 0.05) from those of UV lamps at a similar intensity. On microbiological media, UV-LED treatments at 266 and 270 nm showed significantly different (P < 0.05) inactivation effects than other wavelength modules. For sliced cheeses, 4- to 5-log reductions occurred after treatment at 3 mJ/cm2 for all three pathogens, with negligible generation of injured cells. PMID:26386061

  4. 40 CFR 266.210 - What definitions apply to this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waste described in 40 CFR 261.3. Hazardous Waste means any material which is defined to be hazardous waste in accordance with 40 CFR 261.3, “Definition of Hazardous Waste.” Land Disposal Restriction (LDR...

  5. 40 CFR 266.109 - Low risk waste exemption.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of fuel fired to the device shall be fossil fuel, fuels derived from fossil fuel, tall oil, or, if... comparable to fossil fuel. Such fuels are termed “primary fuel” for purposes of this section. (Tall oil is a...

  6. 40 CFR 266.109 - Low risk waste exemption.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of fuel fired to the device shall be fossil fuel, fuels derived from fossil fuel, tall oil, or, if... comparable to fossil fuel. Such fuels are termed “primary fuel” for purposes of this section. (Tall oil is a...

  7. 40 CFR 266.109 - Low risk waste exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of fuel fired to the device shall be fossil fuel, fuels derived from fossil fuel, tall oil, or, if... comparable to fossil fuel. Such fuels are termed “primary fuel” for purposes of this section. (Tall oil is a...

  8. 40 CFR 266.109 - Low risk waste exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of fuel fired to the device shall be fossil fuel, fuels derived from fossil fuel, tall oil, or, if... comparable to fossil fuel. Such fuels are termed “primary fuel” for purposes of this section. (Tall oil is a...

  9. 40 CFR 266.109 - Low risk waste exemption.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of fuel fired to the device shall be fossil fuel, fuels derived from fossil fuel, tall oil, or, if... comparable to fossil fuel. Such fuels are termed “primary fuel” for purposes of this section. (Tall oil is a...

  10. Home, Department of Administration, State of Alaska

    Science.gov Websites

    anytime, toll-free at 1-877-266-4357 State Office Closures Office Closure Information and Links Office Closure Policy and Procedures (pdf) For recorded alerts: Toll-Free 877-326-5551 In Juneau 465-5551 Popular

  11. 20 CFR 266.13 - When a new representative payee will be selected.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... When the Board learns that the interests of the annuitant are not served by continuing payment to the... wishes to be representative payee; (e) Is unable to manage the benefit payments; or (f) Fails to...

  12. 24 CFR 266.654 - Final claim settlement and HFA Debenture redemption.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., HUD will charge the HFA's Dedicated Account for the amount owed the Department. In cases of top-tier... Agreement. (c) Losses. Losses sustained as a consequence of the (sole) negligence of an HFA (e.g., failure...

  13. 40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... residues collected from areas downstream of the combustion chamber (e.g., ductwork, boiler tubes, heat exchange surfaces, air pollution control devices, etc.). Note to the table: Analysis is not required for...

  14. 40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... residues collected from areas downstream of the combustion chamber (e.g., ductwork, boiler tubes, heat exchange surfaces, air pollution control devices, etc.). Note to the table: Analysis is not required for...

  15. 40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... residues collected from areas downstream of the combustion chamber (e.g., ductwork, boiler tubes, heat exchange surfaces, air pollution control devices, etc.). Note to the table: Analysis is not required for...

  16. 40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... residues collected from areas downstream of the combustion chamber (e.g., ductwork, boiler tubes, heat exchange surfaces, air pollution control devices, etc.). Note to the table: Analysis is not required for...

  17. 40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... residues collected from areas downstream of the combustion chamber (e.g., ductwork, boiler tubes, heat exchange surfaces, air pollution control devices, etc.). Note to the table: Analysis is not required for...

  18. 21 CFR 26.6 - Equivalence assessment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... draft programs for assessing the equivalence of the respective regulatory systems in terms of quality... inspection reports), joint training, and joint inspections for the purpose of assessing regulatory systems...

  19. 31 CFR 348.0 - Offering of securities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Department of the Treasury designated under federal law (including, but not limited to: 12 U.S.C. 90, 265-266, 1464(k), and 1789a; 31 U.S.C. 3303) which have executed a Depositary, Financial Agency, and Collateral...

  20. 7 CFR 1924.266 - Purposes for which claims may be approved.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Law 103-354 debt; and (D) Process an application for a new RH loan if the borrower so desires and is... the defect. (5) Treatment for physical or psychological damages including medical and dental claims...

  1. 20 CFR 266.13 - When a new representative payee will be selected.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... When the Board learns that the interests of the annuitant are not served by continuing payment to the... wishes to be representative payee; (e) Is unable to manage the benefit payments; or (f) Fails to...

  2. 77 FR 266 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Advance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... dumping or a countervailable subsidy (as the case may be) and of material injury. Upcoming Sunset Reviews... Sunset Reviews are set forth in 19 CFR 351.218. Guidance on methodological or analytical issues relevant...

  3. 27 CFR 24.266 - Inventory losses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... business each tax year, or where a cycle different from the tax year has been established as provided in § 24.313, the inventory will be taken annually at the end of that cycle, or at any time required by an...

  4. Investigation of Dual Active Nuclei, Outflows, Shock-heated Gas, and Young Star Clusters in Markarian 266

    NASA Astrophysics Data System (ADS)

    Mazzarella, J. M.; Iwasawa, K.; Vavilkin, T.; Armus, L.; Kim, D.-C.; Bothun, G.; Evans, A. S.; Spoon, H. W. W.; Haan, S.; Howell, J. H.; Lord, S.; Marshall, J. A.; Ishida, C. M.; Xu, C. K.; Petric, A.; Sanders, D. B.; Surace, J. A.; Appleton, P.; Chan, B. H. P.; Frayer, D. T.; Inami, H.; Khachikian, E. Ye.; Madore, B. F.; Privon, G. C.; Sturm, E.; U, Vivian; Veilleux, S.

    2012-11-01

    Results of observations with the Spitzer, Hubble, GALEX, Chandra, and XMM-Newton space telescopes are presented for the luminous infrared galaxy (LIRG) merger Markarian 266. The SW (Seyfert 2) and NE (LINER) nuclei reside in galaxies with Hubble types SBb (pec) and S0/a (pec), respectively. Both companions are more luminous than L* galaxies and they are inferred to each contain a ≈2.5 × 108 M ⊙ black hole. Although the nuclei have an observed hard X-ray flux ratio of fX (NE)/fX (SW) = 6.4, Mrk 266 SW is likely the primary source of a bright Fe Kα line detected from the system, consistent with the reflection-dominated X-ray spectrum of a heavily obscured active galactic nucleus (AGN). Optical knots embedded in an arc with aligned radio continuum radiation, combined with luminous H2 line emission, provide evidence for a radiative bow shock in an AGN-driven outflow surrounding the NE nucleus. A soft X-ray emission feature modeled as shock-heated plasma with T ~ 107 K is cospatial with radio continuum emission between the galaxies. Mid-infrared diagnostics provide mixed results, but overall suggest a composite system with roughly equal contributions of AGN and starburst radiation powering the bolometric luminosity. Approximately 120 star clusters have been detected, with most having estimated ages less than 50 Myr. Detection of 24 μm emission aligned with soft X-rays, radio continuum, and ionized gas emission extending ~34'' (20 kpc) north of the galaxies is interpreted as ~2 × 107 M ⊙ of dust entrained in an outflowing superwind. At optical wavelengths this Northern Loop region is resolved into a fragmented morphology indicative of Rayleigh-Taylor instabilities in an expanding shell of ionized gas. Mrk 266 demonstrates that the dust "blow-out" phase can begin in a LIRG well before the galaxies fully coalesce during a subsequent ultraluminous infrared galaxy (ULIRG) phase, and rapid gas consumption in luminous dual AGNs with kiloparsec-scale separations early in the merger process may explain the paucity of detected binary QSOs (with parsec-scale orbital separations) in spectroscopic surveys. An evolutionary sequence is proposed representing a progression from dual to binary AGNs, accompanied by an increase in observed Lx /L ir ratios by over two orders of magnitude.

  5. Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V)

    PubMed Central

    Armstrong, Stephen P.; Seeber, Ruth M.; Ayoub, Mohammed Akli; Feldman, Brian J.; Pfleger, Kevin D. G.

    2013-01-01

    Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased cAMP levels, trafficking of aquaporin-2 water channels, and consequent increased water permeability and antidiuresis. Typically, loss-of-function V2R mutations cause nephrogenic diabetes insipidus (NDI), whereas gain-of-function mutations cause nephrogenic syndrome of inappropriate antidiuresis (NSIAD). Here we provide further characterization of two mutant V2Rs, R181C and M311V, reported to cause complete and partial NDI respectively, together with a V266A variant, in a patient diagnosed with NSIAD. Our data in HEK293FT cells revealed that for cAMP accumulation, AVP was about 500- or 30-fold less potent at the R181C and M311V mutants than at the wild-type receptor respectively (and about 4000- and 60-fold in COS7 cells respectively). However, in contrast to wild type V2R, the R181C mutant failed to increase inositol phosphate production, while with the M311V mutant, AVP exhibited only partial agonism in addition to a 37-fold potency decrease. Similar responses were detected in a BRET assay for β-arrestin recruitment, with the R181C receptor unresponsive to AVP, and partial agonism with a 23-fold decrease in potency observed with M311V in both HEK293FT and COS7 cells. Notably, the V266A V2R appeared functionally identical to the wild-type receptor in all assays tested, including cAMP and inositol phosphate accumulation, β-arrestin interaction, and in a BRET assay of receptor ubiquitination. Each receptor was expressed at comparable levels. Hence, the M311V V2R retains greater activity than the R181C mutant, consistent with the milder phenotype of NDI associated with this mutant. Notably, the R181C mutant appears to be a Gs protein-biased receptor incapable of signaling to inositol phosphate or recruiting β-arrestin. The etiology of NSIAD in the patient with V266A V2R remains unknown. PMID:23762448

  6. Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V).

    PubMed

    Armstrong, Stephen P; Seeber, Ruth M; Ayoub, Mohammed Akli; Feldman, Brian J; Pfleger, Kevin D G

    2013-01-01

    Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased cAMP levels, trafficking of aquaporin-2 water channels, and consequent increased water permeability and antidiuresis. Typically, loss-of-function V2R mutations cause nephrogenic diabetes insipidus (NDI), whereas gain-of-function mutations cause nephrogenic syndrome of inappropriate antidiuresis (NSIAD). Here we provide further characterization of two mutant V2Rs, R181C and M311V, reported to cause complete and partial NDI respectively, together with a V266A variant, in a patient diagnosed with NSIAD. Our data in HEK293FT cells revealed that for cAMP accumulation, AVP was about 500- or 30-fold less potent at the R181C and M311V mutants than at the wild-type receptor respectively (and about 4000- and 60-fold in COS7 cells respectively). However, in contrast to wild type V2R, the R181C mutant failed to increase inositol phosphate production, while with the M311V mutant, AVP exhibited only partial agonism in addition to a 37-fold potency decrease. Similar responses were detected in a BRET assay for β-arrestin recruitment, with the R181C receptor unresponsive to AVP, and partial agonism with a 23-fold decrease in potency observed with M311V in both HEK293FT and COS7 cells. Notably, the V266A V2R appeared functionally identical to the wild-type receptor in all assays tested, including cAMP and inositol phosphate accumulation, β-arrestin interaction, and in a BRET assay of receptor ubiquitination. Each receptor was expressed at comparable levels. Hence, the M311V V2R retains greater activity than the R181C mutant, consistent with the milder phenotype of NDI associated with this mutant. Notably, the R181C mutant appears to be a Gs protein-biased receptor incapable of signaling to inositol phosphate or recruiting β-arrestin. The etiology of NSIAD in the patient with V266A V2R remains unknown.

  7. Asymptomatic bacteriuria in sickle cell disease: a cross-sectional study

    PubMed Central

    Cumming, Vanessa; Ali, Susanna; Forrester, Terrence; Roye-Green, Karen; Reid, Marvin

    2006-01-01

    Background It is known that there is significant morbidity associated with urinary tract infection and with renal dysfunction in sickle cell disease (SCD). However, it is not known if there are potential adverse outcomes associated with asymptomatic bacteriuria (ASB) infections in sickle cell disease if left untreated. This study was undertaken to determine the prevalence of ASB, in a cohort of patients with SCD. Methods This is a cross-sectional study of patients in the Jamaican Sickle Cell Cohort. Aseptically collected mid-stream urine (MSU) samples were obtained from 266 patients for urinalysis, culture and sensitivity analysis. Proteinuria was measured by urine dipsticks. Individuals with abnormal urine culture results had repeat urine culture. Serum creatinine was measured and steady state haematology and uric acid concentrations were obtained from clinical records. This was completed at a primary care health clinic dedicated to sickle cell diseases in Kingston, Jamaica. There were 133 males and 133 females in the sample studied. The mean age (mean ± sd) of participants was 26.6 ± 2.5 years. The main outcome measures were the culture of ≥ 105 colony forming units of a urinary tract pathogen per milliliter of urine from a MSU specimen on a single occasion (probable ASB) or on consecutive occasions (confirmed ASB). Results Of the 266 urines collected, 234 were sterile and 29 had significant bacteriuria yielding a prevalence of probable ASB of 10.9% (29/266). Fourteen patients had confirmed ASB (prevalence 5.3%) of which 13 had pyuria. Controlling for genotype, females were 14.7 times more likely to have confirmed ASB compared to males (95%CI 1.8 to 121.0). The number of recorded visits for symptomatic UTI was increased by a factor of 2.5 (95% CI 1.4 to 4.5, p < 0.005) but serum creatinine, uric acid and haematology values were not different in patients with confirmed ASB compared with those with sterile urine. There was no association with history of gram negative sepsis. Conclusion ASB is a significant problem in individuals with SCD and may be the source of pathogens in UTI. However, further research is needed to determine the clinical significance of ASB in SCD. PMID:16539735

  8. The effect of preparation taper on the retention of cemented cast crowns under lateral fatigue loading.

    PubMed

    Cameron, Stephen M; Morris, W Jack; Keesee, Stephen M; Barsky, Todd B; Parker, M Harry

    2006-06-01

    Clinicians have used resistance form as a basis for determining guidelines for preparation design to ensure clinical success of cemented cast restorations. Disagreement on whether clinical success follows the on-off or linear nature of resistance form continues. The purpose of this study was to evaluate the number of cycles required to dislodge a cemented complete crown casting under a cyclic lateral load as a function of taper and to compare this relationship for the resistive and nonresistive ranges of taper. Three dies were milled from stainless steel at each of the following tapers: 4, 8, 12, 16, 20, 24, 28, and 32 degrees. A gold-palladium metal-ceramic alloy crown was fabricated for each die, cemented, and subjected to lateral cyclic loading until failure or 1,000,000 cycles. The limiting taper for the dies with their given height and base was 26.6 degrees. Dies with taper less than 26.6 degrees had resistance form, whereas dies with taper larger than 26.6 degrees did not. A linear regression (alpha=.05) was used to evaluate the relation of cycles at dislodgement to taper. The average number of cycles to crown dislodgement or completion for each taper (SD), in units of 10,000, was as follows: 4 degrees, 100 (0); 8 degrees, 100 (0); 12 degrees, 93.54 (16.56); 16 degrees, 61.33 (38.47); 20 degrees, 25.73 (34.67); 24 degrees, 4.33 (7.36); 28 degrees, 0.06 (0.08); and 32 degrees, 0.05 (0.09). The crowns in the resistive area less than 26.6 degrees that demonstrated failure showed a linear regression with a correlation coefficient of -0.995 between the average number of cycles to dislodge the crown and the taper. The slope was significantly different from zero (P=.0048), with a value of -7.58 and a standard error of 0.53. The number of cycles required to cause crown dislodgement was linear after 12 degrees in the resistive area and nearly zero for preparations in the nonresistive area. The limiting taper concept closely predicted the transition point where the slope of the graph of cycles to dislodgement as a function of taper abruptly changed.

  9. 24 CFR 266.500 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

  10. 32 CFR 266.5 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AUDITS OF STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS... governments, institutions of higher education and other nonprofit institutions. (2) For State and local governments, institutions of higher education, and other nonprofit institutions for which the OMB has assigned...

  11. 32 CFR 266.5 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AUDITS OF STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS... governments, institutions of higher education and other nonprofit institutions. (2) For State and local governments, institutions of higher education, and other nonprofit institutions for which the OMB has assigned...

  12. 32 CFR 266.5 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AUDITS OF STATE AND LOCAL GOVERNMENTS, INSTITUTIONS OF HIGHER EDUCATION, AND OTHER NONPROFIT INSTITUTIONS... governments, institutions of higher education and other nonprofit institutions. (2) For State and local governments, institutions of higher education, and other nonprofit institutions for which the OMB has assigned...

  13. 76 FR 38404 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ...: Vascular Biology. Date: July 11, 2011. Time: 12 p.m. to 2 p.m. Agenda: To review and evaluate grant... Scientific Review Special Emphasis Panel, PAR-10-266 Dynamics and Functions of NEDD8 In Cellular Control...

  14. 20 CFR 266.5 - Order of preference in selecting a representative payee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... demonstrates strong concern for the personal welfare of the annuitant; (2) A friend who has custody of the... relative or close friend who does not have custody of the annuitant but is demonstrating concern for the...

  15. 20 CFR 266.5 - Order of preference in selecting a representative payee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... demonstrates strong concern for the personal welfare of the annuitant; (2) A friend who has custody of the... relative or close friend who does not have custody of the annuitant but is demonstrating concern for the...

  16. 49 CFR 266.19 - Environmental impact.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... environmental assessment concludes that the future use significantly affects the quality of human environment... improvement assistance—(1) Environmental assessment. (i) When an applicant requests substitute service... shall: (A) Prepare an environmental assessment to determine whether the future use of the property will...

  17. 24 CFR 266.500 - General.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

  18. 24 CFR 266.500 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

  19. 24 CFR 266.500 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

  20. 24 CFR 266.500 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

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