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Sample records for boks jhannes sigurjnsson

  1. BOK-Printed Electronics

    NASA Technical Reports Server (NTRS)

    Ghaffarian, Reza

    2013-01-01

    The use of printed electronics technologies (PETs), 2D or 3D printing approaches either by conventional electronic fabrication or by rapid graphic printing of organic or nonorganic electronic devices on various small or large rigid or flexible substrates, is projected to grow exponentially in commercial industry. This has provided an opportunity to determine whether or not PETs could be applicable for low volume and high-reliability applications. This report presents a summary of literature surveyed and provides a body of knowledge (BOK) gathered on the current status of organic and printed electronics technologies. It reviews three key industry roadmaps- on this subject-OE-A, ITRS, and iNEMI-each with a different name identification for this emerging technology. This followed by a brief review of the status of the industry on standard development for this technology, including IEEE and IPC specifications. The report concludes with key technologies and applications and provides a technology hierarchy similar to those of conventional microelectronics for electronics packaging. Understanding key technology roadmaps, parameters, and applications is important when judicially selecting and narrowing the follow-up of new and emerging applicable technologies for evaluation, as well as the low risk insertion of organic, large area, and printed electronics.

  2. Cell Biology: ERADicating Survival with BOK.

    PubMed

    Chipuk, Jerry Edward; Luna-Vargas, Mark P

    2016-06-01

    Mechanistic insights into the function of the pro-apoptotic BCL-2 family member BOK have remained elusive. A recent study shows that healthy cells constitutively degrade BOK via the ER-associated degradation and ubiquitin-proteasome pathways; following proteasome inhibition, BOK is stabilized to initiate a unique pro-apoptotic death program.

  3. APPA's BOK: Are You Ready to Participate?

    ERIC Educational Resources Information Center

    Reynolds, Gary L.

    2013-01-01

    The BOK (Body of Knowledge) is APPA's "Facilities Management" online manual. It makes information readily available, anytime and anywhere, to not only its members at all its institutions, but to anyone. Web media allows the BOK to be updated as needed, and includes links to additional resources. Because the BOK is an important part…

  4. Beyond Bok: Historical Jurisprudence in Replacement of the Enlightenment Project.

    ERIC Educational Resources Information Center

    Young, Stephen B.

    1985-01-01

    The approach taken by Derek Bok in his call for fundamental changes in the American legal system and in legal education is examined and contrasted with an approach based on historical jurisprudence. (MSE)

  5. On the origins of polarization holes in Bok globules

    NASA Astrophysics Data System (ADS)

    Brauer, R.; Wolf, S.; Reissl, S.

    2016-04-01

    Context. Polarimetric observations of Bok globules frequently show a decrease in the degree of polarization towards their central dense regions (polarization holes). This behaviour is usually explained with increased disalignment owing to high density and temperature, or insufficient angular resolution of a possibly complex magnetic field structure. Aims: We investigate whether a significant decrease in polarized emission of dense regions in Bok globules is possible under certain physical conditions. For instance, we evaluate the impact of optical depth effects and various properties of the dust phase. Methods: We use radiative transfer modelling to calculate the temperature structure of an analytical Bok globule model and simulate the polarized thermal emission of elongated dust grains. For the alignment of the dust grains, we consider a magnetic field and include radiative torque and internal alignment. Results: Besides the usual explanations, selected conditions of the temperature and density distribution, the dust phase and the magnetic field are also able to significantly decrease the polarized emission of dense regions in Bok globules. Taking submm/mm grains and typical column densities of existing Bok globules into consideration, the optical depth is high enough to decrease the degree of polarization by up to ΔP ~ 10%. If limited to the densest regions, dust grain growth to submm/mm size and accumulated graphite grains decrease the degree of polarization by up to ΔP ~ 10% and ΔP ~ 5%, respectively. However, the effect of the graphite grains occurs only if they do not align with the magnetic field.

  6. Intracellular localization of the BCL-2 family member BOK and functional implications

    PubMed Central

    Echeverry, N; Bachmann, D; Ke, F; Strasser, A; Simon, H U; Kaufmann, T

    2013-01-01

    The pro-apoptotic BCL-2 family member BOK is widely expressed and resembles the multi-BH domain proteins BAX and BAK based on its amino acid sequence. The genomic region encoding BOK was reported to be frequently deleted in human cancer and it has therefore been hypothesized that BOK functions as a tumor suppressor. However, little is known about the molecular functions of BOK. We show that enforced expression of BOK activates the intrinsic (mitochondrial) apoptotic pathway in BAX/BAK-proficient cells but fails to kill cells lacking both BAX and BAK or sensitize them to cytotoxic insults. Interestingly, major portions of endogenous BOK are localized to and partially inserted into the membranes of the Golgi apparatus as well as the endoplasmic reticulum (ER) and associated membranes. The C-terminal transmembrane domain of BOK thereby constitutes a ‘tail-anchor' specific for targeting to the Golgi and ER. Overexpression of full-length BOK causes early fragmentation of ER and Golgi compartments. A role for BOK on the Golgi apparatus and the ER is supported by an abnormal response of Bok-deficient cells to the Golgi/ER stressor brefeldin A. Based on these results, we propose that major functions of BOK are exerted at the Golgi and ER membranes and that BOK induces apoptosis in a manner dependent on BAX and BAK. PMID:23429263

  7. ISO Observations of Starless Bok Globules: Usually No Embedded Stars

    NASA Technical Reports Server (NTRS)

    Clemens, D.; Byrne, A.; Yun, J.; Kane, B.

    1996-01-01

    We have used ISOCAM to search the cores of a sample of small Bok globules previously classified to be mostly starless based on analysis of IRAS data. The ISO observations at 6.75microns (LW2 filter) and 14.5microns (LW3 filter) were sufficiently deep to enable detection of any low-mass hydrogen burning star or young stellar object (YSO) embedded in these globules. Of the 20 Bok globules observed by ISOCAM to date, we have reduced the data for 14. Of these, 13 show no evidence for faint red (S(sub v)(LW3) greater than S(sub v)(LW2)) stars missed by IRAS. One (CB68) does show the first mid-infrared detection of the very cool IRAS source toward this cloud, and may be a Class I or 0 YSO. We conclude, based on these new ISO observations, that Bok globules which have no IRAS sources are in general bona fide starless molecular clouds.

  8. Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection.

    PubMed

    Cai, Jia; Yu, Dapeng; Wei, Shina; Tang, Jufen; Lu, Yishan; Wu, Zaohe; Qin, Qiwei; Jian, Jichang

    2016-05-01

    Apoptosis plays vital roles in many physiological process and immune response. BOK is one of the central regulators in apoptosis. In this study, a new BOK homolog (Ec-BOK) was cloned and characterized from Orange-spotted grouper, Epinephelus coioides. Ec-BOK encoded a 210 amino acid peptides which shared 97% identity to Stegastes partitus BOK protein, contained four BH domains and one transmembrane region. Ec-BOK widely expressed in all analyzed tissues with the higher expressions in kidney and spleen. Its expression level was up-regulated after SGIV infection in vitro. Further analysis revealed that overexpression of Ec-BOK inhibited viral genes transcriptions and virus replication in fish cell. Our findings suggested that Ec-BOK might play a role in the immune response against virus.

  9. Assessing Historically Black College and University (HBCU) Students' Familiarity with the FCS-BOK

    ERIC Educational Resources Information Center

    Lee, Sung-Jin; Williams-Wheeler, Meeshay; Walker, Jane

    2015-01-01

    University faculty who are teaching courses in family and consumer sciences (FCS) have sought to integrate the body of knowledge (BOK) in their curricula. This article reports on a study assessing the familiarity of Historically Black College and University (HBCU) students with the FCS-BOK by their major (specialized area) and classification…

  10. Improving Students' Familiarity with the Family and Consumer Sciences Body of Knowledge (FCS-BOK)

    ERIC Educational Resources Information Center

    Walker, Jane; Williams-Wheeler, Meeshay; Lee, Sung-Jin

    2015-01-01

    Because the family and consumer sciences body of knowledge (FCS-BOK) is the framework for the profession, students' familiarity with the FCS-BOK has implications for the profession. Using pre- (N = 78) and posttest (N = 43) data from students enrolled in an "Introduction to Family and Consumer Sciences" (FCS 160) undergraduate student…

  11. The effectiveness of the nationwide BokSmart rugby injury prevention program on catastrophic injury rates.

    PubMed

    Brown, J C; Verhagen, E; Knol, D; Van Mechelen, W; Lambert, M I

    2016-02-01

    Rugby Union ("rugby") participants have a higher than average risk of injury compared with participants of other popular team sports. BokSmart, a nationwide injury prevention program was launched in South Africa in mid-2009, with the goal of reducing catastrophic head/neck (serious) injuries in players. The program provides injury prevention information to coaches and referees. This study investigated if BokSmart has been associated with a reduction in these injuries. The BokSmart program collected data on all South African rugby-related serious injuries since 2008. Using a Poisson regression, injury numbers were compared pre-BokSmart (2008-2009) to the years post-implementation (2010-2013). Player numbers were assumed to be constant throughout this evaluation: junior = 529,483; senior = 121,663. In junior players, the "post-BokSmart" period had 2.5 less annual serious injuries than "pre-BokSmart" (incidence rate ratio: 0.6, 95% confidence interval: 0.5-0.7, P < 0.000). In contrast, there was no significant difference in these periods in seniors. The absence of effect in seniors may be a result of fewer players or of differences in effectiveness of BokSmart in this group--future studies should investigate these questions.

  12. Molecular profiles and pathogen-induced transcriptional responses of prawn B cell lymphoma-2 related ovarian killer protein (BOK).

    PubMed

    Chaurasia, Mukesh Kumar; Palanisamy, Rajesh; Harikrishnan, Ramasamy; Arasu, Mariadhas Valan; Al-Dhabi, Naif Abdullah; Arockiaraj, Jesu

    2015-08-01

    In this study, we have reported a molecular characterization of the first B cell lymphoma-2 (BCL-2) related ovarian killer protein (BOK) from freshwater prawn Macrobrachium rosenbergii (Mr). BOK is a novel pro-apoptotic protein of the BCL-2 family that entails in mediating apoptosis to remove cancer cells. A cDNA sequence of MrBOK was identified from the prawn cDNA library and its full length was obtained by internal sequencing. The coding region of MrBOK yields a polypeptide of 291 amino acids. The analysis revealed that MrBOK contains a transmembrane helix at V(261)-L(283) and a putative BCL-2 family domain at V(144)-W(245). MrBOK also possessed four putative BCL-2 homology domains including BH1, BH2, BH3 and weak BH4. The BH3 contains 21 binding sites and among them five residues are highly conserved with the aligned BOK proteins. The homology analysis showed that MrBOK shared maximum similarity with the Caligus rogercresseyi BOK A. The topology of the phylogenetic tree was classified into nine sister groups which includes BOK, BAK, BAX, BAD, BCL-2, BCL-XL, NR13 and MCL members. The BOK protein group further sub-grouped into vertebrate and invertebrate BOK, wherein MrBOK located within insect monophyletic clad of invertebrate BOK. The secondary structural analysis showed that MrBOK contains 11 α-helices (52.2%) which are connected over random coils (47.7%). The 3D structure of MrBOK showed three central helices (α6, α7 and α8) which formed the core of the protein and are flanked on one side by α1, α2 and α3, and on the other side by α4, α5 and α11. MrBOK mRNA is expressed most abundantly (P < 0.05) in ovary compared to other tissues taken for analysis. Hence ovary was selected to study the possible roles of MrBOK mRNA regulation upon bacterial (Aeromonas hydrophila and Vibrio harveyi) and viral [white spot syndrome virus (WSSV) and M. rosenbergii nodovirus] infection. During bacterial and viral infection, the highest MrBOK mRNA transcription was varied

  13. The Bok Award Presented for High School Astronomy Research at the Intel Science Fair

    NASA Astrophysics Data System (ADS)

    Garmany, Catharine D.

    2013-01-01

    The Priscilla and Bart Bok award, presented jointly by the Astronomical Society of the Pacific (ASP) and the American Astronomical Society (AAS) at the annual Intel International Science and Engineering Fair (ISEF), recognizes excellent research in astronomy conducted by high school students. The award is named in honor of two well-known astronomers. Bart Bok was an outstanding research astronomer: much of his research was done with his wife, Priscilla Fairfield Bok. Since 1992, the ASP and the AAS have shared the responsibility of sending three judges to the annual Intel ISEF to select two Bok awardees. Funds for the prizes themselves are derived from an endowment in Bart Bok’s honor held at the ASP. The Intel ISEF is a massive event. In order to become a finalist and attend ISEF, a student must first compete, and win one of the top awards, in both their local and regional science fairs. In recent years, about 1,500 high-school students have attended. About 100 of these students present projects in the category physics: of these, less than 20 are astronomy projects. Winners of the award are invited to attend the winter AAS meeting, and this year both of the 2012 winners are expected to be in attendance. There are also previous winners who are actively in our midst. But there is an unanswered question: why are there so few student projects in astronomy?

  14. THE KEPLER LIGHT CURVE OF THE UNIQUE DA WHITE DWARF BOKS 53856

    SciTech Connect

    Holberg, J. B.; Howell, Steve B. E-mail: howell@noao.edu

    2011-08-15

    The faint (g = 16.9) hot white dwarf BOKS 53856 was observed by the Kepler Mission in short cadence mode during mid-2009. Analysis of these observations reveals a highly stable modulation with a period of 6.1375 hr and a 2.46% half-amplitude. The folded light curve has an unusual shape that is difficult to explain in terms of a binary system containing an unseen companion more luminous than an L0 brown dwarf. Optical spectra of BOKS 53856 show a T{sub eff} = 34,000 K, log g = 8.0 DA white dwarf. There are few, if any, known white dwarfs in this temperature range exhibiting photometric variations similar to those we describe. A magnetic spin-modulated white dwarf model can in principle explain the light curve, an interpretation supported by spectral observations of the H{alpha} line showing evidence of Zeeman splitting.

  15. WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer

    SciTech Connect

    Zeilstra, Jurrit; Joosten, Sander P.J.; Wensveen, Felix M.; Dessing, Mark C.; Schuetze, Denise M.; Eldering, Eric; Spaargaren, Marcel; Pals, Steven T.

    2011-03-04

    Research highlights: {yields} Intestinal adenomas initiated by aberrant activation of the WNT pathway displayed an increased sensitivity to apoptosis. {yields} Expression profiling of apoptosis-related genes in Apc{sup Min/+} mice revealed the differential expression of pro-apoptotic Bok and Bax. {yields} APC-mutant adenomatous crypts in FAP patients showed strongly increased BAX immunoreactivity. {yields} Blocking of {beta}-catenin/TCF-4-mediated signaling in colon cancer cells reduced the expression of BOK and BAX. -- Abstract: In a majority of cases, colorectal cancer is initiated by aberrant activation of the WNT signaling pathway. Mutation of the genes encoding the WNT signaling components adenomatous polyposis coli or {beta}-catenin causes constitutively active {beta}-catenin/TCF-mediated transcription, driving the transformation of intestinal crypts to cancer precursor lesions, called dysplastic aberrant crypt foci. Deregulated apoptosis is a hallmark of adenomatous colon tissue. However, the contribution of WNT signaling to this process is not fully understood. We addressed this role by analyzing the rate of epithelial apoptosis in aberrant crypts and adenomas of the Apc{sup Min/+} mouse model. In comparison with normal crypts and adenomas, aberrant crypts displayed a dramatically increased rate of apoptotic cell death. Expression profiling of apoptosis-related genes along the crypt-villus axis and in Apc mutant adenomas revealed increased expression of two pro-apoptotic Bcl-2 family members in intestinal adenomas, Bok and Bax. Analysis of the colon of familial adenomatous polyposis (FAP) patients along the crypt-to-surface axis, and of dysplastic crypts, corroborated this expression pattern. Disruption of {beta}-catenin/TCF-4-mediated signaling in the colorectal cancer cell line Ls174T significantly decreased BOK and BAX expression, confirming WNT-dependent regulation in intestinal epithelial cells. Our results suggest a feedback mechanism by which

  16. Anthocyanin accumulation and transcriptional regulation of anthocyanin biosynthesis in purple bok choy (Brassica rapa var. chinensis).

    PubMed

    Zhang, Yanjie; Chen, Guoping; Dong, Tingting; Pan, Yu; Zhao, Zhiping; Tian, Shibing; Hu, Zongli

    2014-12-24

    Bok choy (Brassica rapa var. chinensis) is an important dietary vegetable cultivated and consumed worldwide for its edible leaves. The purple cultivars rich in health-promoting anthocyanins are usually more eye-catching and valuable. Fifteen kinds of anthocyanins were separated and identified from a purple bok choy cultivar (Zi He) by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. To investigate the molecular mechanisms underlying anthocyanin accumulation in bok choy, the expression profiles of anthocyanin biosynthetic and regulatory genes were analyzed in seedlings and leaves of the purple cultivar and the green cultivar (Su Zhouqing). Compared with the other tissues, BrTT8 and most of the anthocyanin biosynthetic genes were significantly up-regulated in the leaves and light-grown seedlings of Zi He. The results that heterologous expression of BrTT8 promotes the transcription of partial anthocyanin biosynthetic genes in regeneration shoots of tomato indicate that BrTT8 plays an important role in the regulation of anthocyanin biosynthesis.

  17. Anthocyanin accumulation and transcriptional regulation of anthocyanin biosynthesis in purple bok choy (Brassica rapa var. chinensis).

    PubMed

    Zhang, Yanjie; Chen, Guoping; Dong, Tingting; Pan, Yu; Zhao, Zhiping; Tian, Shibing; Hu, Zongli

    2014-12-24

    Bok choy (Brassica rapa var. chinensis) is an important dietary vegetable cultivated and consumed worldwide for its edible leaves. The purple cultivars rich in health-promoting anthocyanins are usually more eye-catching and valuable. Fifteen kinds of anthocyanins were separated and identified from a purple bok choy cultivar (Zi He) by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. To investigate the molecular mechanisms underlying anthocyanin accumulation in bok choy, the expression profiles of anthocyanin biosynthetic and regulatory genes were analyzed in seedlings and leaves of the purple cultivar and the green cultivar (Su Zhouqing). Compared with the other tissues, BrTT8 and most of the anthocyanin biosynthetic genes were significantly up-regulated in the leaves and light-grown seedlings of Zi He. The results that heterologous expression of BrTT8 promotes the transcription of partial anthocyanin biosynthetic genes in regeneration shoots of tomato indicate that BrTT8 plays an important role in the regulation of anthocyanin biosynthesis. PMID:25419600

  18. BOKS 45906: a CV with an Orbital Period of 56.6 Min in the Kepler Field?

    NASA Technical Reports Server (NTRS)

    Ramsay, Gavin; Howell, Steve B.; Wood, Matt A.; Smale, Alan; Barclay, Thomas; Seebode, Sally A.; Gelino, Dawn; Still, Martin; Cannizzo, John K.

    2013-01-01

    BOKS 45906 was found to be a blue source in the Burrell-Optical-Kepler Survey which showed a 3 magnitude outburst lasting approximately 5 days. We present the Kepler light curve of this source which covers nearly 3 years. We find that it is in a faint optical state for approximately half the time and shows a series of outbursts separated by distinct dips in flux. Using data with 1 minute sampling, we find clear evidence that in its low state BOKS 45906 shows a flux variability on a period of 56.5574 plus or minus 0.0014 minutes and a semi-amplitude of approximately 3 percent. Since we can phase all the 1 minute cadence data on a common ephemeris using this period, it is probable that 56.56 minutes is the binary orbital period. Optical spectra of BOKS 45906 show the presence of Balmer lines in emission indicating it is not an AM CVn (pure Helium) binary. Swift data show that it is a weak X-ray source and is weakly detected in the bluest of the UVOT filters. We conclude that BOKS 45906 is a cataclysmic variable with a period shorter than the 'period-bounce' systems and therefore BOKS 45906 could be the first helium-rich cataclysmic variable detected in the Kepler field.

  19. Effects of endocrine disruptor di-n-butyl phthalate on the growth of Bok choy (Brassica rapa subsp. chinensis).

    PubMed

    Liao, Chien-Sen; Yen, Jui-Hung; Wang, Yei-Shung

    2006-12-01

    The effects of the endocrine disrupter, di-n-butyl phthalate (DBP), on the growth of leaf vegetable Bok choy (Brassica rapa subsp. chinensis, white stem Bok choy) were investigated. The results showed that leaves of Bok choy became white in color with the occurrence of chlorosis and necrosis upon treating with 30 mg l(-1) DBP for 42 days. Transmission electron microscopic images revealed that changes in the chloroplast structures accompanied the chlorosis. In addition, a decrease in biomass and chlorophyll, and accumulation of DBP, were found in DBP-treated Bok choy. The growth and morphology of Bok choy showed a significant dose-response relationship upon treatment with DBP in a hydroponic culture medium. The proteome of the leaf tissue was analyzed using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). Six protein spots were identified in 2-DE that showed reproducible differences in expression between the normal control and the DBP-treated sample. Based on proteome level studies two protein spots increased and were identified as superoxide dismutase (SOD) and peroxidase 21 precursor. These proteins are believed to increase in expression in response to free radical exposure as a detoxification mechanism. The other four protein spots that disappeared on treatment with DBP were identified as heat shock cognate protein 80, protein disulfide isomerase precursor, apocytochrome f precursor, and RNA polymerase beta subunit. The first two play an important role in polypeptide folding, the third is associated with electron transport, and the last has a critical function in DNA transcription. This study indicated that DBP affects the proteome formation as well as the physiology and the morphology of Bok choy during growth. The decrease in those four proteins might be related to the growth and development of a plant.

  20. Effects of endocrine disruptor di-n-butyl phthalate on the growth of Bok choy (Brassica rapa subsp. chinensis).

    PubMed

    Liao, Chien-Sen; Yen, Jui-Hung; Wang, Yei-Shung

    2006-12-01

    The effects of the endocrine disrupter, di-n-butyl phthalate (DBP), on the growth of leaf vegetable Bok choy (Brassica rapa subsp. chinensis, white stem Bok choy) were investigated. The results showed that leaves of Bok choy became white in color with the occurrence of chlorosis and necrosis upon treating with 30 mg l(-1) DBP for 42 days. Transmission electron microscopic images revealed that changes in the chloroplast structures accompanied the chlorosis. In addition, a decrease in biomass and chlorophyll, and accumulation of DBP, were found in DBP-treated Bok choy. The growth and morphology of Bok choy showed a significant dose-response relationship upon treatment with DBP in a hydroponic culture medium. The proteome of the leaf tissue was analyzed using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). Six protein spots were identified in 2-DE that showed reproducible differences in expression between the normal control and the DBP-treated sample. Based on proteome level studies two protein spots increased and were identified as superoxide dismutase (SOD) and peroxidase 21 precursor. These proteins are believed to increase in expression in response to free radical exposure as a detoxification mechanism. The other four protein spots that disappeared on treatment with DBP were identified as heat shock cognate protein 80, protein disulfide isomerase precursor, apocytochrome f precursor, and RNA polymerase beta subunit. The first two play an important role in polypeptide folding, the third is associated with electron transport, and the last has a critical function in DNA transcription. This study indicated that DBP affects the proteome formation as well as the physiology and the morphology of Bok choy during growth. The decrease in those four proteins might be related to the growth and development of a plant. PMID:16824579

  1. Hazard map of agricultural products due to typhoons-an example of Bok-choy

    NASA Astrophysics Data System (ADS)

    Lin, Yong-Jun; Ma, Kuo-Chen; Lai, Jihn-Sung; Chang, Tsang-Jung; Tan, Yih-Chi

    2015-04-01

    The torrential rain and strong wind brought by typhoons usually cause huge damages to agricultural products. This study aims at hazard map of agricultural products due to typhoons. The factors affecting the hazard of agricultural products due to typhoons include the duration of flooding, flooding depth, wind speed, and rainfall intensity. High rainfall intensity and high wind speed may knock down the leaves or fruits of the plants. The long-duration of flooding or high flooding depth may chock the plant or rotten the roots. In order to get the information needed for making hazard map due to assumed scenarios, an overland flow simulations is performed for getting the duration of flooding and maximum flooding in the study area. The data of wind speed is obtained from metrological stations. Four levels of hazard are defined due to the characteristic of the chosen agricultural products- Bok-choy (such average height of mature Bok-choy). The final goal of this study is to establish a real-time hazard evaluation system for the specific agricultural products.

  2. C[superscript 2] = BOK: Two Apparel Studies' Capstone Courses Incorporating the Body of Knowledge

    ERIC Educational Resources Information Center

    Smith, Kathleen R.; Apple, Laurie; Souhtward, Leigh

    2014-01-01

    Guided by the five cross-cutting themes of the American Association of Family & Consumer Sciences (AAFCS) Body of Knowledge (BOK) two capstone courses (C[superscript 2]) in Apparel Studies were designed to help prepare students for careers, further study, or both.

  3. Jeans analysis of Bok globules in {\\varvec{f(R)}} gravity

    NASA Astrophysics Data System (ADS)

    Vainio, Jaakko; Vilja, Iiro

    2016-10-01

    We examine the effects of f( R) gravity on Jeans analysis of collapsing dust clouds. We provide a method for testing modified gravity models by their effects on star formation as the presence of f(R) gravity is found to modify the limit for collapse. In this analysis we add perturbations to a de Sitter background. As the standard Einstein-Hilbert Lagrangian is modified, new types of dynamics emerge. Depending on the characteristics of a chosen f( R) model, the appearance of new limits is possible. The physicality of these limits is further examined. We find the asymptotic Jeans masses for f( R) theories compared to standard Jeans mass. Through this ratio, the effects of the f( R) modified Jeans mass for viable theories are examined in molecular clouds. Bok globules have a mass range comparable to Jeans masses in question and are therefore used for comparing different f( R) models. Viable theories are found to assist in star formation.

  4. The Priscilla and Bart Bok Award, presented by the ASP and the AAS at the Intel International Science and Engineering Fair

    NASA Astrophysics Data System (ADS)

    Garmany, K.

    2013-04-01

    The Bok Award is presented to high school students for astronomy research. While there are relatively few astronomy projects at this fair, many of the winners of this award have continued in the field of astronomy.

  5. VizieR Online Data Catalog: Stellar Distribution near the South Galactic Pole (Bok+ 1964)

    NASA Astrophysics Data System (ADS)

    Bok, B. J.; Basinski, J.

    1995-06-01

    This catalog contains a field of 2.8 square degrees centered on Kapteyn Selected Area 141 (l=245, b=-86). The center of field was near SAO 166815 (Bok I 174 B) at 01 05 11 -29 33 12 (1950). The covered ranges were 01 01 30 < RA < 01 09 30 and -30 20 < Dec < -28 35 (1950). Photographic V magnitudes and B-V colors of 640 stars were measured in Region I. Data were card punched at the Australian National University on an Univac 1100/82. The coordinates were determined by Kavan U. Ratnatunga from PDS scans of the region on UKSTU Schmidt plate J6657S (taken on 03-Jan-1981) and visual cross identifications were given with the published finding chart. The coordinate calibration used the positions of SAO stars. Estimated rms accuracies for the following measurements are: Visual Magnitude: 0.03 mag B-V colors : 0.05 mag Positions : 1 arc second (1 data file).

  6. Discovery of a Hot Corino in the Bok Globule B335

    NASA Astrophysics Data System (ADS)

    Imai, Muneaki; Sakai, Nami; Oya, Yoko; López-Sepulcre, Ana; Watanabe, Yoshimasa; Ceccarelli, Cecilia; Lefloch, Bertrand; Caux, Emmanuel; Vastel, Charlotte; Kahane, Claudine; Sakai, Takeshi; Hirota, Tomoya; Aikawa, Yuri; Yamamoto, Satoshi

    2016-10-01

    We report the first evidence of a hot corino in a Bok globule. This is based on ALMA observations in the 1.2 mm band toward the low-mass Class 0 protostar IRAS 19347+0727 in B335. Saturated complex organic molecules (COMs), CH3CHO, HCOOCH3, and NH2CHO, are detected in a compact region within a few 10 au around the protostar. Additionally, CH3OCH3, C2H5OH, C2H5CN, and CH3COCH3 are tentatively detected. Carbon-chain related molecules, CCH and c-C3H2, are also found in this source, whose distributions are extended over a scale of a few 100 au. On the other hand, sulfur-bearing molecules CS, SO, and SO2 have both compact and extended components. Fractional abundances of the COMs relative to H2 are found to be comparable to those in known hot corino sources. Though the COMs lines are as broad as 5–8 km s‑1, they do not show obvious rotation motion in the present observation. Thus, the COMs mainly exist in a structure whose distribution is much smaller than the synthesized beam (0.″58 × 0.″52).

  7. Spitzer and HHT Observations of Bok Globule B335: Isolated Star Formation Efficiency and Cloud Structure

    NASA Astrophysics Data System (ADS)

    Stutz, Amelia M.; Rubin, Mark; Werner, Michael W.; Rieke, George H.; Bieging, John H.; Keene, Jocelyn; Kang, Miju; Shirley, Yancy L.; Su, K. Y. L.; Velusamy, Thangasamy; Wilner, David J.

    2008-11-01

    We present infrared and millimeter observations of Barnard 335, the prototypical isolated Bok globule with an embedded protostar. Using Spitzer data we measure the source luminosity accurately; we also constrain the density profile of the innermost globule material near the protostar using the observation of an 8.0 μm shadow. Heinrich Hertz Telescope (HHT) observations of 12CO 2-1 confirm the detection of a flattened molecular core with diameter ~10,000 AU and the same orientation as the circumstellar disk (~100 to 200 AU in diameter). This structure is probably the same as that generating the 8.0 μm shadow and is expected from theoretical simulations of collapsing embedded protostars. We estimate the mass of the protostar to be only ~5% of the mass of the parent globule. This work is based in part on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 1407.

  8. Analysis of genetic diversity of Brassica rapa var. chinensis using ISSR markers and development of SCAR marker specific for Fragrant Bok Choy, a product of geographic indication.

    PubMed

    Shen, X L; Zhang, Y M; Xue, J Y; Li, M M; Lin, Y B; Sun, X Q; Hang, Y Y

    2016-04-25

    Non-heading Chinese cabbage [Brassica rapa var. chinensis (Linnaeus) Kitamura] is a popular vegetable and is also used as a medicinal plant in traditional Chinese medicine. Fragrant Bok Choy is a unique accession of non-heading Chinese cabbage and a product of geographic indication certified by the Ministry of Agriculture of China, which is noted for its rich aromatic flavor. However, transitional and overlapping morphological traits can make it difficult to distinguish this accession from other non-heading Chinese cabbages. This study aimed to develop a molecular method for efficient identification of Fragrant Bok Choy. Genetic diversity analysis, based on inter-simple sequence repeat molecular markers, was conducted for 11 non-heading Chinese cabbage accessions grown in the Yangtze River Delta region. Genetic similarity coefficients between the 11 accessions ranged from 0.5455 to 0.8961, and the genetic distance ranged from 0.0755 to 0.4475. Cluster analysis divided the 11 accessions into two major groups. The primer ISSR-840 amplified a fragment specific for Fragrant Bok Choy. A pair of specific sequence-characterized amplified region (SCAR) primers based on this fragment amplified a target band in Fragrant Bok Choy individuals, but no band was detected in individuals of other accessions. In conclusion, this study has developed an efficient strategy for authentication of Fragrant Bok Choy. The SCAR marker described here will facilitate the conservation and utilization of this unique non-heading Chinese cabbage germplasm resource.

  9. Analysis of genetic diversity of Brassica rapa var. chinensis using ISSR markers and development of SCAR marker specific for Fragrant Bok Choy, a product of geographic indication.

    PubMed

    Shen, X L; Zhang, Y M; Xue, J Y; Li, M M; Lin, Y B; Sun, X Q; Hang, Y Y

    2016-01-01

    Non-heading Chinese cabbage [Brassica rapa var. chinensis (Linnaeus) Kitamura] is a popular vegetable and is also used as a medicinal plant in traditional Chinese medicine. Fragrant Bok Choy is a unique accession of non-heading Chinese cabbage and a product of geographic indication certified by the Ministry of Agriculture of China, which is noted for its rich aromatic flavor. However, transitional and overlapping morphological traits can make it difficult to distinguish this accession from other non-heading Chinese cabbages. This study aimed to develop a molecular method for efficient identification of Fragrant Bok Choy. Genetic diversity analysis, based on inter-simple sequence repeat molecular markers, was conducted for 11 non-heading Chinese cabbage accessions grown in the Yangtze River Delta region. Genetic similarity coefficients between the 11 accessions ranged from 0.5455 to 0.8961, and the genetic distance ranged from 0.0755 to 0.4475. Cluster analysis divided the 11 accessions into two major groups. The primer ISSR-840 amplified a fragment specific for Fragrant Bok Choy. A pair of specific sequence-characterized amplified region (SCAR) primers based on this fragment amplified a target band in Fragrant Bok Choy individuals, but no band was detected in individuals of other accessions. In conclusion, this study has developed an efficient strategy for authentication of Fragrant Bok Choy. The SCAR marker described here will facilitate the conservation and utilization of this unique non-heading Chinese cabbage germplasm resource. PMID:27173238

  10. SUBMILLIMETER ARRAY AND SPITZER OBSERVATIONS OF BOK GLOBULE CB 17: A CANDIDATE FIRST HYDROSTATIC CORE?

    SciTech Connect

    Chen Xuepeng; Arce, Hector G.; Dunham, Michael M.; Zhang Qizhou; Bourke, Tyler L.; Launhardt, Ralf; Schmalzl, Markus; Henning, Thomas

    2012-06-01

    We present high angular resolution Submillimeter Array (SMA) and Spitzer observations toward the Bok globule CB 17. SMA 1.3 mm dust continuum images reveal within CB 17 two sources with an angular separation of {approx}21'' ({approx}5250 AU at a distance of {approx}250 pc). The northwestern continuum source, referred to as CB 17 IRS, dominates the infrared emission in the Spitzer images, drives a bipolar outflow extending in the northwest-southeast direction, and is classified as a low-luminosity Class 0/I transition object (L{sub bol} {approx} 0.5 L{sub Sun }). The southeastern continuum source, referred to as CB 17 MMS, has faint dust continuum emission in the SMA 1.3 mm observations ({approx}6{sigma} detection; {approx}3.8 mJy), but is not detected in the deep Spitzer infrared images at wavelengths from 3.6 to 70 {mu}m. Its bolometric luminosity and temperature, estimated from its spectral energy distribution, are {<=}0.04 L{sub Sun} and {<=}16 K, respectively. The SMA CO (2-1) observations suggest that CB 17 MMS may drive a low-velocity molecular outflow ({approx}2.5 km s{sup -1}), extending in the east-west direction. Comparisons with prestellar cores and Class 0 protostars suggest that CB 17 MMS is more evolved than prestellar cores but less evolved than Class 0 protostars. The observed characteristics of CB 17 MMS are consistent with the theoretical predictions from radiative/magnetohydrodynamical simulations of a first hydrostatic core, but there is also the possibility that CB 17 MMS is an extremely low luminosity protostar deeply embedded in an edge-on circumstellar disk. Further observations are needed to study the properties of CB 17 MMS and to address more precisely its evolutionary stage.

  11. Study of magnetic field geometry and extinction in Bok globule CB130

    NASA Astrophysics Data System (ADS)

    Chakraborty, A.; Das, H. S.

    2016-09-01

    We trace the peripheral magnetic field structure of Bok globule CB130 by estimating the linear polarization of its field stars in the R band. The magnetic field orientation sampled by these stars, aligned on average among themselves, and the polarization produced within the cloud has a different direction from that of Galactic plane with an offset of 53°. The offset between minor axis and the mean magnetic field of CB130 is found to be 80°. The estimated strength of the magnetic field in the plane-of-the-sky is ˜116±19 μG. We constructed the visual extinction map using the Near Infrared Color Excess (NICE) method to see the dust distribution around CB130. Contours of Herschel (Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA) SPIRE 500 μm dust continuum emission map of this cloud is over-plotted on the visual extinction map, which shows that the regions having higher optical extinction correspond to higher densities of dust. Three distinct high dust density cores (named as C1, C2, and C3) are identified in the extinction map. It is observed that the cores C1 and C3 are located close to two previously known cores CB130-1 and CB130-2, respectively. Estimates of visual extinction of some moderately obscured stars of CB130 are made utilizing near-infrared photometry. It is observed that there is a feeble dependence of polarization on extinction, and the polarization efficiency (defined as p/AV) of the dust grains decreases with the increase in extinction.

  12. Relationships between soil properties and toxicity of copper and nickel to bok choy and tomato in Chinese soils.

    PubMed

    Li, Bo; Zhang, Hongtao; Ma, Yibing; McLaughlin, Mike J

    2013-10-01

    The toxicity of copper (Cu) and nickel (Ni) to bok choy and tomato shoot growth was investigated in a wide range of Chinese soils with and without leaching with artificial rainwater. The results showed that the variations of Ni toxicity induced by soil properties were wider than those of Cu toxicity to both tomato and bok choy plant growth. Leaching generally decreased the toxicity of Cu and Ni added to soils, which also depended on soils, metals, and test plant species. Soil factors controlling metal phytotoxicity were found to be soil pH and soil organic carbon content for Cu, and soil pH for Ni. It was also found that soil pH had stronger effects on Ni toxicity than on Cu toxicity. Predictive toxicity models based on these soil factors were developed. These toxicity models for Cu and Ni toxicity to tomato plant growth were validated using an independent data set for European soils. These models could be applied to predict the Cu and Ni phytotoxicity in not only Chinese soils but also European soils.

  13. Relationships between soil properties and toxicity of copper and nickel to bok choy and tomato in Chinese soils.

    PubMed

    Li, Bo; Zhang, Hongtao; Ma, Yibing; McLaughlin, Mike J

    2013-10-01

    The toxicity of copper (Cu) and nickel (Ni) to bok choy and tomato shoot growth was investigated in a wide range of Chinese soils with and without leaching with artificial rainwater. The results showed that the variations of Ni toxicity induced by soil properties were wider than those of Cu toxicity to both tomato and bok choy plant growth. Leaching generally decreased the toxicity of Cu and Ni added to soils, which also depended on soils, metals, and test plant species. Soil factors controlling metal phytotoxicity were found to be soil pH and soil organic carbon content for Cu, and soil pH for Ni. It was also found that soil pH had stronger effects on Ni toxicity than on Cu toxicity. Predictive toxicity models based on these soil factors were developed. These toxicity models for Cu and Ni toxicity to tomato plant growth were validated using an independent data set for European soils. These models could be applied to predict the Cu and Ni phytotoxicity in not only Chinese soils but also European soils. PMID:23787779

  14. Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK

    PubMed Central

    Ke, F; Grabow, S; Kelly, G L; Lin, A; O'Reilly, L A; Strasser, A

    2015-01-01

    It is well established that BAX and BAK play crucial, overlapping roles in the intrinsic pathway of apoptosis. Gene targeted mice lacking both BAX and BAK have previously been generated, but the majority of these animals died perinatally. BOK is a poorly studied relative of BAX and BAK that shares extensive amino acid sequence homology to both proteins, but its function remains largely unclear to date. To determine whether BOK plays an overlapping role with BAX and BAK, we utilized a hematopoietic reconstitution model where lethally irradiated wild type mice were transplanted with Bok−/−Bax−/−Bak−/− triple knockout (TKO) fetal liver cells, and compared alongside mice reconstituted with a Bax−/−Bak−/− double knockout (DKO) hematopoietic compartment. We report here that mice with a TKO and DKO hematopoietic system died at a similar rate and much earlier than control animals, mostly due to severe autoimmune pathology. Both TKO and DKO reconstituted mice also had altered frequencies of various leukocyte subsets in the thymus, bone marrow and spleen, displayed leukocyte infiltrates and autoimmune pathology in multiple tissues, as well as elevated levels of anti-nuclear autoantibodies. Interestingly, the additional deletion of BOK (on top of BAX and BAK loss) led to a further increase in peripheral blood lymphocytes, as well as enhanced lymphoid infiltration in some organs. These findings suggest that BOK may have some functions that are redundant with BAX and BAK in the hematopoietic system. PMID:26492371

  15. The formation of interstellar molecular lines in a turbulent velocity field with finite correlation length. IV. Physical parameters of Bok Gobules

    NASA Astrophysics Data System (ADS)

    Hegmann, M.; Hengel, C.; Röllig, M.; Kegel, W. H.

    2006-01-01

    We present observational line data for five Bok Globules. Observations were made in the J=2 → 1 and J=3 → 2 rotational transitions of CO, 13CO and C18O at the Heinrich-Hertz-Telescope in Arizona. Using the stochastic radiative transfer model (SRTM) based on the generalized radiative transfer equation as described in the previous papers of this series, we were able to fit the observed CO lines for four of the five Bok globules. The derived parameters such as the hydrogen density, the cloud mass and temperature in part differ significantly from values obtained from a standard LVG analysis or a microturbulent approach. The best fits are obtained for models characterized by a ratio of the mean free path of photons to the correlation length of the turbulent velocity field of the order of unity. This is what characterizes the mesoturbulent regime that cannot be adressed by standard evaluation methods like LVG or microturbulent approximations.

  16. Spacewatch Astrometry of Asteroids and Comets with the Bok 2.3-m and Mayall 4-m Telescopes.

    NASA Astrophysics Data System (ADS)

    Scotti, James V.; McMillan, Robert S.; Larsen, Jeffrey A.

    2014-11-01

    We use the Bok 2.3-m and Mayall 4-m telescopes on Kitt Peak to improve knowledge of the orbits and magnitudes of high priority classes of Near Earth Objects (NEOs) and other small bodies in need of recovery that cannot be reached with the Spacewatch 0.9-m and 1.8-m telescopes. Targets include NEOs with potential close encounters with Earth (Virtual Impactors; VIs), future targets of radar, NEOs previously detected by NEOWISE with orbits or albedos suggesting potential for cometary activity, potential destinations for spacecraft, returning NEOs with hard-won albedos and diameters determined by NEOWISE, and faint Potentially Hazardous Asteroids (PHAs). Notable targets successfully recovered include the Earth Trojan 2010 TK7 and the faint almost-lost VI 2011 BY24 discovered by NEOWISE. Between 2010 June 6 and 2014 July 23 the MPC accepted 1316 lines of astrometry by us with these telescopes on 207 different NEOs including 84 PHAs. We made 343 observations of PHAs with V>=22. Our average arc extension on large PHAs (with H<=17.75) is 184 days, which is 2x longer than the next most effective observing station. Recently with all four telescopes Spacewatch has made 39% of all the observations of PHAs that were fainter than V=22 at the time of measurement. This count is twice that of the next most productive station in that measure. The faintest V magnitude we have observed so far is 24.4 and the smallest solar elongation angle at which we have observed is 46 degrees. Our work with the Mayall and Bok telescopes has been determined by the Minor Planet Center (MPC) to provide "dramatic improvement" to NEO orbits (T. Spahr, 2014 private communication). Support of Spacewatch was/is from JPL subcontract 100319 (2010-2011), NASA/NEOO grants NNG06GJ42G, NNX11AB52G, NNX12AG11G, NNX13AP99G, NNX14AL13G, and NNX14AL14G, the Lunar and Planetary Laboratory, the Brinson Foundation of Chicago, IL, the estates of R. S. Vail and R. L. Waland, and other private donors. We are also indebted

  17. Three Views of the River: Three Reviews of "The Shape of the River: Long-Term Consequences of Considering Race in College and University Admissions" by William G. Bowen and Derek Bok.

    ERIC Educational Resources Information Center

    Chavez, Linda; Lerner, Robert; O'Neill, Dave; Clegg, Roger

    This paper presents three reviews of the book, "The Shape of the River: Long-Term Consequences of Considering Race in College and University Admissions," by William Bowen and Derek Bok. The book defends affirmative action in college admissions. The first review says that the book presents important data, but it is seriously flawed overall because…

  18. Body of Knowledge (BOK) for Leadless Quad Flat No-Lead/Bottom Termination Components (QFN/BTC) Package Trends and Reliability

    NASA Technical Reports Server (NTRS)

    Ghaffarian, Reza

    2014-01-01

    Bottom terminated components and quad flat no-lead (BTC/QFN) packages have been extensively used by commercial industry for more than a decade. Cost and performance advantages and the closeness of the packages to the boards make them especially unique for radio frequency (RF) applications. A number of high-reliability parts are now available in this style of package configuration. This report presents a summary of literature surveyed and provides a body of knowledge (BOK) gathered on the status of BTC/QFN and their advanced versions of multi-row QFN (MRQFN) packaging technologies. The report provides a comprehensive review of packaging trends and specifications on design, assembly, and reliability. Emphasis is placed on assembly reliability and associated key design and process parameters because they show lower life than standard leaded package assembly under thermal cycling exposures. Inspection of hidden solder joints for assuring quality is challenging and is similar to ball grid arrays (BGAs). Understanding the key BTC/QFN technology trends, applications, processing parameters, workmanship defects, and reliability behavior is important when judicially selecting and narrowing the follow-on packages for evaluation and testing, as well as for the low risk insertion in high-reliability applications.

  19. Body of Knowledge (BOK) for Leadless Quad Flat No-Lead/bottom Termination Components (QFN/BTC) Package Trends and Reliability

    NASA Technical Reports Server (NTRS)

    Ghaffarian, Reza

    2014-01-01

    Bottom terminated components and quad flat no-lead (BTC/QFN) packages have been extensively used by commercial industry for more than a decade. Cost and performance advantages and the closeness of the packages to the boards make them especially unique for radio frequency (RF) applications. A number of high-reliability parts are now available in this style of package configuration. This report presents a summary of literature surveyed and provides a body of knowledge (BOK) gathered on the status of BTC/QFN and their advanced versions of multi-row QFN (MRQFN) packaging technologies. The report provides a comprehensive review of packaging trends and specifications on design, assembly, and reliability. Emphasis is placed on assembly reliability and associated key design and process parameters because they show lower life than standard leaded package assembly under thermal cycling exposures. Inspection of hidden solder joints for assuring quality is challenging and is similar to ball grid arrays (BGAs). Understanding the key BTC/QFN technology trends, applications, processing parameters, workmanship defects, and reliability behavior is important when judicially selecting and narrowing the follow-on packages for evaluation and testing, as well as for the low risk insertion in high-reliability applications.

  20. Bok Prize Lecture (shared) The Brown Dwarf Radial Velocity Survey

    NASA Astrophysics Data System (ADS)

    Charbonneau, Dave

    2004-03-01

    The swarm of nearby brown dwarfs and very low mass stars is an attractive sample for radial velocity monitoring. Such work is best conducted with an echelle spectrograph operating at infrared wavelengths where these objects(i) are most luminous, (ii) have a forest of molecular features, providing an excellent velocity metric, and {iii) are superimposed on the telluric spectrum, which yields the requisite wavelength calibration. I will present first results from such a survey, with a precision sufficient to detect Jupiter-mass planets with orbital periods of less than a year. Should such systems be uncovered, the planets would be amenable to direct study, due to system proximity, and the favorable contrast ratio between the planet and parent object.

  1. BOK-Underfill Optimization for FPGA Package/Assembly

    NASA Technical Reports Server (NTRS)

    Ghaffarian, Reza

    2011-01-01

    Commercial-off-the-shelf area array package technologies in high-reliability versions are being considered for NASA electronic systems. These packages are prone to early failure due to the severe mechanical shock and vibration of launch, as well as other less severe conditions, such as mechanical loading during descent, rough terrain mobility, handling, and ground tests. As the density of these packages increases and the size of ball interconnections decrease, susceptibility to mechanical loading and cycling fatigue grows. This report presents a summary of the body of knowledge developed for the evaluation of area array packages and is based on surveys of literature from industry and academia. For high-reliability applications, the limited data that exists will be presented. Most data from industry deals with mechanical fatigue caused by four-point bend tests, as well as from drop tests for hand-held electronics; the most recent data will be presented, along with a brief background of prior literature. Understanding the key design guidelines and failure mechanisms from past tests is critical to developing an approach that will minimize future failures. Additional specific testing enables low-risk insertion of these advanced electronic packages.

  2. Book of Knowledge (BOK) for NASA Electronic Packaging Roadmap

    NASA Technical Reports Server (NTRS)

    Ghaffarian, Reza

    2015-01-01

    The objective of this document is to update the NASA roadmap on packaging technologies (initially released in 2007) and to present the current trends toward further reducing size and increasing functionality. Due to the breadth of work being performed in the area of microelectronics packaging, this report presents only a number of key packaging technologies detailed in three industry roadmaps for conventional microelectronics and a more recently introduced roadmap for organic and printed electronics applications. The topics for each category were down-selected by reviewing the 2012 reports of the International Technology Roadmap for Semiconductor (ITRS), the 2013 roadmap reports of the International Electronics Manufacturing Initiative (iNEMI), the 2013 roadmap of association connecting electronics industry (IPC), the Organic Printed Electronics Association (OE-A). The report also summarizes the results of numerous articles and websites specifically discussing the trends in microelectronics packaging technologies.

  3. Body of Knowledge (BOK) for Copper Wire Bonds

    NASA Technical Reports Server (NTRS)

    Rutkowski, E.; Sampson, M. J.

    2015-01-01

    Copper wire bonds have replaced gold wire bonds in the majority of commercial semiconductor devices for the latest technology nodes. Although economics has been the driving mechanism to lower semiconductor packaging costs for a savings of about 20% by replacing gold wire bonds with copper, copper also has materials property advantages over gold. When compared to gold, copper has approximately: 25% lower electrical resistivity, 30% higher thermal conductivity, 75% higher tensile strength and 45% higher modulus of elasticity. Copper wire bonds on aluminum bond pads are also more mechanically robust over time and elevated temperature due to the slower intermetallic formation rate - approximately 1/100th that of the gold to aluminum intermetallic formation rate. However, there are significant tradeoffs with copper wire bonding - copper has twice the hardness of gold which results in a narrower bonding manufacturing process window and requires that the semiconductor companies design more mechanically rigid bonding pads to prevent cratering to both the bond pad and underlying chip structure. Furthermore, copper is significantly more prone to corrosion issues. The semiconductor packaging industry has responded to this corrosion concern by creating a palladium coated copper bonding wire, which is more corrosion resistant than pure copper bonding wire. Also, the selection of the device molding compound is critical because use of environmentally friendly green compounds can result in internal CTE (Coefficient of Thermal Expansion) mismatches with the copper wire bonds that can eventually lead to device failures during thermal cycling. Despite the difficult problems associated with the changeover to copper bonding wire, there are billions of copper wire bonded devices delivered annually to customers. It is noteworthy that Texas Instruments announced in October of 2014 that they are shipping microcircuits containing copper wire bonds for safety critical automotive applications. An evaluation of copper wire bond technology for applicability to spaceflight hardware may be warranted along with concurrently compiling a comprehensive understanding of the failure mechanisms involved with copper wire bonded semiconductor devices.

  4. Bok Prize Lecture (shared) Towards a Physical Characterization of Extrasolar Planets

    NASA Astrophysics Data System (ADS)

    Seager, Sara

    2004-03-01

    We have entered a new era in planetary astrophysics with well over 100 giant planets now known to orbit nearby sun-like stars. Recent theoretical and observational advances have given us new constraints on the physical characteristics of extrasolar planets, while ongoing and proposed observing programs and space missions hold great promise for the future of extrasolar planet science. I will discuss the emerging understanding of the extrasolar transiting planet HD209458b, tying together several recent observational constraints as well as key upcoming measurements.I will also briefly review scientific highlights and prospects for the future detection and study of Earth-like extrasolar planets.

  5. Spitzer Observations of a 24 μm Shadow: Bok Globule CB 190

    NASA Astrophysics Data System (ADS)

    Stutz, Amelia M.; Bieging, John H.; Rieke, George H.; Shirley, Yancy L.; Balog, Zoltan; Gordon, Karl D.; Green, Elizabeth M.; Keene, Jocelyn; Kelly, Brandon C.; Rubin, Mark; Werner, Michael W.

    2007-08-01

    We present Spitzer observations of the dark globule CB 190 (LDN 771). We observe a roughly circular 24 μm shadow with a 70" radius. The extinction profile of this shadow matches the profile derived from 2MASS photometry at the outer edges of the globule and reaches a maximum of ~32 visual magnitudes at the center. The corresponding mass of CB 190 is ~10 Msolar. Our 12CO and 13CO J=2-1 data over a 10'×10' region centered on the shadow show a temperature ~10 K. The thermal continuum indicates a similar temperature for the dust. The molecular data also show evidence of freezeout onto dust grains. We estimate a distance to CB 190 of 400 pc using the spectroscopic parallax of a star associated with the globule. Bonnor-Ebert fits to the density profile, in conjunction with this distance, yield ξmax=7.2, indicating that CB 190 may be unstable. The high temperature (56 K) of the best-fit Bonnor-Ebert model is in contradiction with the CO and thermal continuum data, leading to the conclusion that the thermal pressure is not enough to prevent free-fall collapse. We also find that the turbulence in the cloud is inadequate to support it. However, the cloud may be supported by the magnetic field, if this field is at the average level for dark globules. Since the magnetic field will eventually leak out through ambipolar diffusion, it is likely that CB 190 is collapsing or in a late precollapse stage. This work is based in part on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 1407.

  6. NASA 2009 Body of Knowledge (BoK) Through-Slicon Via Technology

    NASA Technical Reports Server (NTRS)

    Gerke, David

    2009-01-01

    Through-silicon via (TSV) is the latest in a progression of technologies for stacking silicon devices in three dimensions (3D). Driven by the need for improved performance, methods to use short vertical interconnects to replace the long interconnects found in 2D structures have been developed. The industry is moving past the feasibility (research and development [R and D]) phase for TSV technology into the commercialization phase where economic realities will determine which technologies are adopted. Low-cost fine via hole formation and highly reliable via filling technologies have been demonstrated; process equipment and materials are available. Even though design, thermal, and test issues remain, much progress has been made.

  7. Disciplinary Categories, Majors, and Undergraduate Academic Experiences: Rethinking Bok's "Underachieving Colleges" Thesis

    ERIC Educational Resources Information Center

    Brint, Steven; Cantwell, Allison M.; Saxena, Preeta

    2012-01-01

    Using data from the 2008 University of California Undergraduate Experience Survey, we show that study time and academic conscientiousness were lower among students in humanities and social science majors than among students in science and engineering majors. Analytical and critical thinking experiences were no more evident among humanities and…

  8. Creating an Academy of Learning: Authentic Assessment, Peer Review, and the College and Work Readiness Assessment

    ERIC Educational Resources Information Center

    Austin, John

    2010-01-01

    Most agree that schools have a special obligation to study the effectiveness of their educational programs and seek ways to improve student learning. Derek Bok, the former president of Harvard University, has persuasively argued that schools must envision themselves as "learning organizations." Like hospitals and businesses, Bok writes, schools…

  9. Promoting Strong Community Alliances with Public Schools

    ERIC Educational Resources Information Center

    Swafford, Melinda; Ramsey, Elizabeth; Self-Mullens, Lizabeth

    2015-01-01

    Family and consumer sciences (FCS) professionals utilize the body of knowledge (BOK) as they support individuals, families, and communities. The BOK uses an ecological perspective, with emphasis on individual and family well-being. This holistic approach identifies interdependence of the environmental layers that must be considered when analyzing…

  10. VizieR Online Data Catalog: Isolated starless cores dust temperature (Lippok+, 2016)

    NASA Astrophysics Data System (ADS)

    Lippok, N.; Launhardt, R.; Henning, T.; Beuther, H.; Balog, Z.; Kainulainen, J.; Krause, O.; Linz, H.; Nielbock, M.; Ragan, S. E.; Robitaille, T. P.; Sadavoy, S. I.; Schmiedeke, A.

    2016-06-01

    Dust temperature maps for 6 Bok globules with starless cores are presented. The following Bok globules have been observed: CB4, CB17, CB26, CB27, B68, CB244 The midplane dust temperature [K] maps are provides as fits files. (2 data files).

  11. Phenolic component profiles of mustard greens, yu choy, and 15 other brassica vegetables.

    PubMed

    Lin, Long-Ze; Harnly, James M

    2010-06-01

    A liquid chromatography-mass spectrometry (LC-MS) profiling method was used to characterize the phenolic components of 17 leafy vegetables from Brassica species other than Brassica oleracea. The vegetables studied were mustard green, baby mustard green, gai choy, baby gai choy, yu choy, yu choy tip, bok choy, bok choy tip, baby bok choy, bok choy sum, Taiwan bok choy, Shanghai bok choy, baby Shanghai bok choy, rapini broccoli, turnip green, napa, and baby napa. This work led to the tentative identification of 71 phenolic compounds consisting of kaempferol 3-O-diglucoside-7-O-glucoside derivatives, isorhamnetin 3-O-glucoside-7-O-glucoside hydroxycinnamoyl gentiobioses, hydroxycinnamoylmalic acids, and hydroxycinnamoylquinic acids. Ten of the compounds, 3-O-diacyltriglucoside-7-O-glucosides of kaempferol and quercetin, had not been previously reported. The phenolic component profiles of these vegetables were significantly different than those of the leafy vegetables from B. oleracea. This is the first comparative study of these leafy vegetables. Ten of the vegetables had never been previously studied by LC-MS.

  12. Phenolic Component Profiles of Mustard Greens, Yu Choy, and 15 Other Brassica Vegetables

    PubMed Central

    Lin, Long-Ze; Harnly, James M

    2013-01-01

    A liquid chromatography–mass spectrometry (LC-MS) profiling method was used to characterize the phenolic components of 17 leafy vegetables from Brassica species other than Brassica oleracea. The vegetables studied were mustard green, baby mustard green, gai choy, baby gai choy, yu choy, yu choy tip, bok choy, bok choy tip, baby bok choy, bok choy sum, Taiwan bok choy, Shanghai bok choy, baby Shanghai bok choy, rapini broccoli, turnip green, napa, and baby napa. This work led to the tentative identification of 71 phenolic compounds consisting of kaempferol 3-O-diglucoside-7-O-glucoside derivatives, isorhamnetin 3-O-glucoside-7-O-glucoside hydroxycinnamoyl gentiobioses, hydroxycinnamoylmalic acids, and hydroxycinnamoylquinic acids. Ten of the compounds, 3-O-diacyltriglucoside-7-O-glucosides of kaempferol and quercetin, had not been previously reported. The phenolic component profiles of these vegetables were significantly different than those of the leafy vegetables from B. oleracea. This is the first comparative study of these leafy vegetables. Ten of the vegetables had never been previously studied by LC-MS. PMID:20465307

  13. Phenolic component profiles of mustard greens, yu choy, and 15 other brassica vegetables.

    PubMed

    Lin, Long-Ze; Harnly, James M

    2010-06-01

    A liquid chromatography-mass spectrometry (LC-MS) profiling method was used to characterize the phenolic components of 17 leafy vegetables from Brassica species other than Brassica oleracea. The vegetables studied were mustard green, baby mustard green, gai choy, baby gai choy, yu choy, yu choy tip, bok choy, bok choy tip, baby bok choy, bok choy sum, Taiwan bok choy, Shanghai bok choy, baby Shanghai bok choy, rapini broccoli, turnip green, napa, and baby napa. This work led to the tentative identification of 71 phenolic compounds consisting of kaempferol 3-O-diglucoside-7-O-glucoside derivatives, isorhamnetin 3-O-glucoside-7-O-glucoside hydroxycinnamoyl gentiobioses, hydroxycinnamoylmalic acids, and hydroxycinnamoylquinic acids. Ten of the compounds, 3-O-diacyltriglucoside-7-O-glucosides of kaempferol and quercetin, had not been previously reported. The phenolic component profiles of these vegetables were significantly different than those of the leafy vegetables from B. oleracea. This is the first comparative study of these leafy vegetables. Ten of the vegetables had never been previously studied by LC-MS. PMID:20465307

  14. 40 CFR 180.110 - Maneb; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Chinese, bok choy 10 None Cabbage, Chinese, napa 10 None Carrot, roots 7 None Cauliflower 10 None Celery 5... None Turnip, greens 10 None Turnip, roots 7 None (b) Section 18 emergency exemptions. A...

  15. 40 CFR 180.110 - Maneb; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Chinese, bok choy 10 None Cabbage, Chinese, napa 10 None Carrot, roots 7 None Cauliflower 10 None Celery 5... None Turnip, greens 10 None Turnip, roots 7 None (b) Section 18 emergency exemptions. (c)...

  16. Spectroscopic classification of AT2016ghq as a Type Ia

    NASA Astrophysics Data System (ADS)

    Andrews, Jennifer; Smith, Nathan; Milne, Peter; Moe, Maxwell

    2016-09-01

    The AZTEC (Arizona Transient Exploration and Characterization) collaboration reports an optical spectrum of AT2016ghq obtained on UT 20156 Sep. 22.33 with the 2.3m Bok telescope (+ Boller & Chivens spectrograph) on Kitt Peak, Arizona.

  17. Nutrition Guide for Toddlers

    MedlinePlus

    ... cooked dry beans, or 1 egg. continue Milk Matters An important part of a toddler's diet, milk ... fortified breads and cereals, cooked dried beans, and dark green vegetables like broccoli, bok choy, and kale. ...

  18. 40 CFR 180.253 - Methomyl; tolerances for residues.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Bermudagrass, forage 10 Bermudagrass, hay 40 Blueberry 6 Broccoli 3 Brussels sprouts 2 Cabbage 5 Cabbage, Chinese, bok choy 5 Cabbage, Chinese, napa 5 Cauliflower 2 Celery 3 Collards 6 Corn, field, forage 10...

  19. 40 CFR 180.253 - Methomyl; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Bermudagrass, forage 10 Bermudagrass, hay 40 Blueberry 6 Broccoli 3 Brussels sprouts 2 Cabbage 5 Cabbage, Chinese, bok choy 5 Cabbage, Chinese, napa 5 Cauliflower 2 Celery 3 Collards 6 Corn, field, forage 10...

  20. 40 CFR 180.253 - Methomyl; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Bermudagrass, forage 10 Bermudagrass, hay 40 Blueberry 6 Broccoli 3 Brussels sprouts 2 Cabbage 5 Cabbage, Chinese, bok choy 5 Cabbage, Chinese, napa 5 Cauliflower 2 Celery 3 Collards 6 Corn, field, forage 10...

  1. Calcium, vitamin D, and your bones

    MedlinePlus

    Green leafy vegetables, such as broccoli, collards, kale, mustard greens, turnip greens, and bok choy (Chinese cabbage), are good sources of calcium. Other good food sources of calcium are: Salmon and ...

  2. ASASSN-15lu is a Type Ia Supernova

    NASA Astrophysics Data System (ADS)

    Leonard, D. C.; Sheehan, P.; McCarthy, D.; Follette, K.; Moustakas, J.; Cantillo, D.; Cazares-Kelly, A.; Cazares-Kelly, S.; Cendes, Y.; Damm, N.; Donati, A.; Douglas, E.; Ferrell, L.; Fosbiner-Elkins, H.; Fox, C.; Greenberg, M.; Hart, K.; Hensley, H.; Holt, A.; Hooper, E.; Juran, C.; Keane, J.; Key, K.; Korus, L.; Lee, T.; Leidig, K.; Merchak, E.; Nessmann, K.; Pendyala, S.; Pirkl, S.; Reeder, J.; Roos, A.; Rounseville, S.; Ruddy, E.; Schlingman, A.; Schlingman, W.; Schlingman, W.; Schwartzman, E.; Shanmugam, V.; Silver, E.; Stein, A.; Stock, N.; Svoboda, B.; Thomas, B.; Thomas, N.; Thompson-Taylor, K.; Walton, H.

    2015-06-01

    We report spectroscopic classification of ASASSN-15lu (ATel #7698) in SDSS J132112.88+401556.7 (z=0.035037, via NED) through inspection of an optical spectrum (range 370-680 nm, resolution 0.8 nm), obtained with the 2.3-m Bok telescope (+ Boller & Chivens spectrograph) at Kitt Peak on 2015 June 24.2 UT.

  3. Optical Spectroscopy of PSN J15044078+1237436

    NASA Astrophysics Data System (ADS)

    Leonard, D. C.; Sheehan, P.; McCarthy, D.; Follette, K.; Moustakas, J.; Cantillo, D.; Cazares-Kelly, A.; Cazares-Kelly, S.; Cendes, Y.; Damm, N.; Donati, A.; Douglas, E.; Ferrell, L.; Fosbiner-Elkins, H.; Fox, C.; Greenberg, M.; Hart, K.; Hensley, H.; Holt, A.; Hooper, E.; Juran, C.; Keane, J.; Key, K.; Korus, L.; Lee, T.; Leidig, K.; Merchak, E.; Nessmann, K.; Pendyala, S.; Pirkl, S.; Reeder, J.; Roos, A.; Rounseville, S.; Ruddy, E.; Schlingman, A.; Schlingman, W.; Schlingman, W.; Schwartzman, E.; Shanmugam, V.; Silver, E.; Stein, A.; Stock, N.; Svoboda, B.; Thomas, B.; Thomas, N.; Thompson-Taylor, K.; Walton, H.

    2015-06-01

    We report on optical spectroscopic observations of PSN J15044078+1237436 in NGC 5837 (z = 0.028723; Fisher et al. 1995, ApJ Suppl 100, 69, via NED) taken on 2015 June 20.3 and 2015 June 21.3 UT with the 2.3-m Bok telescope (+ Boller & Chivens spectrograph) at Kitt Peak.

  4. Universities in the Marketplace: The Commercialization of Higher Education

    ERIC Educational Resources Information Center

    Bok, Derek

    2004-01-01

    Is everything in a university for sale if the price is right? In this book, one of America's leading educators cautions that the answer is all too often "yes." Taking the first comprehensive look at the growing commercialization of our academic institutions, Derek Bok probes the efforts on campus to profit financially not only from athletics but…

  5. The Changing Shape of the River: Affirmative Action and Recent Social Science Research

    ERIC Educational Resources Information Center

    Nieli, Russell

    2004-01-01

    In the eyes of much of the academic establishment, William Bowen and Derek Bok's "The Shape of the River" is the definitive defense of affirmative action. Released in 1998, this book, which was also sponsored by the Mellon Foundation, claimed that racial preferences at America's elite universities were crucial to the growth and maintenance of a…

  6. Assessing Intercultural Competence

    ERIC Educational Resources Information Center

    Deardorff, Darla K.

    2011-01-01

    In his book "Our Underachieving Colleges," Derek Bok laments the poor job postsecondary institutions are doing in preparing students for the twenty-first century. Other scholars have likewise noted the central responsibility of today's institutions of higher education being to train students to function more effectively in the integrated world…

  7. Lightcurve Analysis for Seven Main-belt Asteroids

    NASA Astrophysics Data System (ADS)

    Casalnuovo, Giovanni Battitsa

    2015-04-01

    Photometric observations of seven main-belt asteroids were made at the Eurac Observatory (C62 in Bolzano- Italy) in 2014: 1983 Bok, 2634 James Bradley, 4252 Godwin, 5116 Korsor, 10597 (1996 TR10), 52505 (1996 FD4), and 53247 (1999 DE2).

  8. Project Produce

    ERIC Educational Resources Information Center

    Wolfinger, Donna M.

    2005-01-01

    The grocery store produce section used to be a familiar but rather dull place. There were bananas next to the oranges next to the limes. Broccoli was next to corn and lettuce. Apples and pears, radishes and onions, eggplants and zucchinis all lay in their appropriate bins. Those days are over. Now, broccoli may be next to bok choy, potatoes beside…

  9. A Model for Developing Improvements to Critical Thinking Skills across the Community College Curriculum

    ERIC Educational Resources Information Center

    McGarrity, DeShawn N.

    2013-01-01

    Society is faced with more complex problems than in the past because of rapid advancements in technology. These complex problems require multi-dimensional problem-solving abilities that are consistent with higher-order thinking skills. Bok (2006) posits that over 90% of U.S. faculty members consider critical thinking skills as essential for…

  10. The "Ladies' Home Journal" between 1890 and 1906: The Influence of Its Crusade To Regulate Food and Drug Products.

    ERIC Educational Resources Information Center

    Harris-Wheeker, Sally A.

    This paper discusses how "The Ladies' Home Journal" was used by its editor, Edward Bok, in his crusade for food and drug regulation in the United States between the years 1890 and 1906, and whether these efforts were influential in bringing about the Pure Food and Drug Act of 1906. The first section describes "The Ladies' Home Journal's" crusade…

  11. The Source of the River: The Social Origins of Freshmen at America's Selective Colleges and Universities

    ERIC Educational Resources Information Center

    Massey, Douglas S.; Charles, Camille Z.; Lundy, Garvey F.; Fischer, Mary J.

    2006-01-01

    African Americans and Latinos earn lower grades and drop out of college more often than whites or Asians. Yet thirty years after deliberate minority recruitment efforts began, we still don't know why. In "The Shape of the River," William Bowen and Derek Bok documented the benefits of affirmative action for minority students, their communities, and…

  12. I've Known Rivers: Reflections on Self-Education and the Cornell Experiment, 1966-1970.

    ERIC Educational Resources Information Center

    McPhail, Irving Pressley

    A graduate of Cornell university's class of 1970 reflects on his experiences as a black undergraduate at Cornell from 1966 to 1970, what affirmative action meant to him and his generation of college students, and the self-education black students experienced at Cornell at that time. William Bowen and Derek Bok recently published "The Shape of the…

  13. Integrating the Family and Consumer Sciences Body of Knowledge into Higher Education: Eight AAFCS-Accredited Universities Explain Their Process

    ERIC Educational Resources Information Center

    Reiboldt, Wendy; Stanley, M. Sue; Coffey, Kitty R.; Whaley, Heather M.; Yazedjian, Ani; Yates, Amy M.; Kihm, Holly; Wanga, Pamela E.; Martin, Lynda; Olle, Mary; Anderson, Melinda

    2016-01-01

    This article features eight AAFCS-accredited academic units in higher education that illustrate how the Family and Consumer Sciences Body of Knowledge (FCS-BOK) can be integrated into program curricula and educational procedures or structures. Contributors represent the following educational institutions (in alphabetical order): (1) California…

  14. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... Commodity Parts per million Almond 0.1 Avocado 0.01 Banana 0.01 Barley, grain 0.1 Cabbage, Chinese, bok choy 0.01 Cabbage, Chinese, napa 0.01 Cacao bean, dried bean 0.1 Cashew 0.1 Citron, citrus 0.01...

  15. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... Commodity Parts per million Almond 0.1 Avocado 0.01 Banana 0.01 Barley, grain 0.1 Cabbage, Chinese, bok choy 0.01 Cabbage, Chinese, napa 0.01 Cacao bean, dried bean 0.1 Cashew 0.1 Citron, citrus 0.01...

  16. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... Commodity Parts per million Almond 0.1 Avocado 0.01 Banana 0.01 Barley, grain 0.1 Cabbage, Chinese, bok choy 0.01 Cabbage, Chinese, napa 0.01 Cacao bean, dried bean 0.1 Cashew 0.1 Citron, citrus 0.01...

  17. 40 CFR 180.349 - Fenamiphos; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....10 None Brussels sprouts 0.05 12/31/09 Cabbage 0.10 12/31/09 Cherry, sweet 0.25 12/31/09 Cherry, tart... Cabbage, Chinese, bok choy 0.50 12/31/09 Kiwifruit 0.10 12/31/09 Pepper, nonbell 0.60 12/31/09...

  18. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... Commodity Parts per million Almond 0.1 Avocado 0.01 Banana 0.01 Barley, grain 0.1 Cabbage, Chinese, bok choy 0.01 Cabbage, Chinese, napa 0.01 Cacao bean, dried bean 0.1 Cashew 0.1 Citron, citrus 0.01...

  19. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Commodity Parts per million Almond 0.1 Avocado 0.01 Banana 0.01 Barley, grain 0.1 Cabbage, Chinese, bok choy 0.01 Cabbage, Chinese, napa 0.01 Cacao bean, dried bean 0.1 Cashew 0.1 Citron, citrus 0.01...

  20. Political Education in/as the Practice of Freedom: A Paradoxical Defence from the Perspective of Michael Oakeshott

    ERIC Educational Resources Information Center

    Engel, Stephen M.

    2007-01-01

    Creating education systems that promote democratic sustainability has been the concern of political thinkers as diverse as J. S. Mill, Dewey, Benjamin Barber and Derek Bok. The classic dichotomisation of democratic theory between deliberative democrats and Schumpeterian democrats suggests that education in the service of democracy can be…

  1. Ethnic and Gender Differences in Science Graduation at Selective Colleges with Implications for Admission Policy and College Choice.

    ERIC Educational Resources Information Center

    Smyth, Frederick L.; McArdle, John J.

    Emphasizing graduation rate, W. Bowen and D. Bok (1998) argue that race-sensitive admission at selective colleges enhances the educational attainment of underrepresented minority students, and that the effect increases with college selectivity. Focusing on graduation in science, however, R. Elliott and colleagues (1995) conclude that: (1)…

  2. Examining a knowledge domain: Interactive visualization of the Geographic Information Science and Technology Body of Knowledge 1

    NASA Astrophysics Data System (ADS)

    Stowell, Marilyn Ruth

    This research compared the effectiveness and performance of interactive visualizations of the GIS&T Body of Knowledge 1. The visualizations were created using Processing, and display the structure and content of the Body of Knowledge using various spatial layout methods: the Indented List, Tree Graph, treemap and Similarity Graph. The first three methods utilize the existing hierarchical structure of the BoK text, while the fourth method (Similarity Graph) serves as a jumping off point for exploring content-based visualizations of the BoK. The following questions have guided the framework of this research: (1) Which of the spatial layouts is most effective for completing tasks related to the GIS&T; BoK overall? How do they compare to each other in terms of performance? (2) Is one spatial layout significantly more or less effective than others for completing a particular cognitive task? (3) Is the user able to utilize the BoK as a basemap or reference system and make inferences based on BoK scorecard overlays? (4) Which design aspects of the interface assist in carrying out the survey objectives? Which design aspects of the application detract from fulfilling the objectives? To answer these questions, human subjects were recruited to participate in a survey, during which they were assigned a random spatial layout and were asked questions about the BoK based on their interaction with the visualization tool. 75 users were tested, 25 for each spatial layout. Statistical analysis revealed that there were no statistically significant differences between means for overall accuracy when comparing the three visualizations. In looking at individual questions, Tree Graph and Indented List yielded statistically significant higher scores for questions regarding the structure of the Body of Knowledge, as compared to the treemap. There was a significant strong positive correlation between the time taken to complete the survey and the final survey score. This correlation was

  3. VizieR Online Data Catalog: U-band photometry of 17 WINGS clusters (Omizzolo+, 2014)

    NASA Astrophysics Data System (ADS)

    Omizzolo, A.; Fasano, G.; Reverte Paya, D.; de Santis, C.; Grado, A.; Bettoni, D.; Poggianti, B.; D'Onofrio, M.; Moretti, A.; Varela, J.; Fritz, J.; Gullieuszik, M.; Cava, A.; Grazian, A.; Moles, M.

    2014-01-01

    The observations were made with three different wide-field cameras: - the 90prime camera at the 90inches (2.3m) BOK telescope (90prime@BOK, Kitt Peak), in 2 runs: 2000-06-20/22 and 2006-11-22/23 - the Wide Field Camera at the 2.5m Isaac Newton Telescope (WFC@INT), in 1 run: 2005-05-10/14 - the Large Binocular Camera at the Large Binocular Telescope (LBC@LBT). on the 5 nights 2007-03-12, 2007-05-19, 2008-06-04, 2008-06-07 and 2008-06-08 - For one cluster (Abell 970) we used imaging data from the WFI@MPG (ESO2.2 archive), performed on 2000-02-27/29 All clusters have been imaged in the U-band, and many clusters have also been imaged in the optical (B,V) bands. (22 data files).

  4. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis).

    PubMed

    Chen, Tianbao; Orr, David F; Bjourson, Anthony J; McClean, Stephen; O'Rourke, Martin; Hirst, David G; Rao, Pingfan; Shaw, Chris

    2002-09-01

    Bradykinin and (Thr(6))-bradykinin have been identified in the defensive skin secretion of the fire-bellied toad, Bombina orientalis. The homologous cDNAs for both peptides were cloned from a skin library using a 3'- and 5'-RACE strategy. Kininogen-1 (BOK-1) contained an open-reading frame of 167 amino acid residues encoding four repeats of bradykinin, and kininogen-2 (BOK-2) contained an open-reading frame of 161 amino acid residues encoding two repeats of (Thr(6))-bradykinin. Alignment of both precursor nucleotide and amino acid sequences revealed a high degree of structural similarity. These amphibian skin kininogens/preprobradykinins are not biologically analogous to mammalian kininogens.

  5. Bappu, Manali Kallat Vainu (1927-82)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Born in Hyderabad, India, of an astronomer father, and became director of the Kodaikanal Observatory. Following a chance meeting with SIR HAROLD SPENCER JONES and HARLOW SHAPLEY, enrolled in Harvard, was co-discoverer of comet Bappu-Bok-Newkirk. Working with OLIN WILSON at the Mount Wilson Observatory, Bappu discovered that for stars of spectral types later than G0 there is a relationship betwee...

  6. Spectroscopy of PSN J19583553+0236163

    NASA Astrophysics Data System (ADS)

    Leonard, D. C.; Moustakas, J.; Swift, B. J.; McCarthy, D.; Bailey, V.; Carrico, E.; Carter, A.; Chui, E.; Douglas, E.; Eggeman, E.; Goldberg, R.; Grant, R.; Hartman, K.; Hellerstein, J.; Hooper, E.; Horlick-Cruz, C.; Hunter, L.; Jiles, T.; Johnson, E. D.; Kumar, K.; Lappe, L.; Lee, J.; Lee, W.; Marsh, F.; Mehta, G.; Miller, P.; Rampalli, R.; Reed, J.; Rice, K.; Saldivar, H.; Salgado-Flores, M.; Schlingman, A.; Schlingman, W. F.; Schlingman, W. M.; Scibelli, S.; Sinclair, K.; Steincamp, I.; Stock, N.; Todd, N.; Vargas, L. L. Aizpuru; Yamanaka, S.; Zachary, E.

    2011-06-01

    As part of the 2011 Advanced Teen Astronomy Camp (http://www.astronomycamp.org), we obtained a low dispersion optical spectrum (range 370-690 nm) of PSN J19583553+0236163 in UGC 11501 with the 2.3m Bok telescope (+ Boller & Chivens spectrograph) at Steward Observatory, on 2011 June 23 UT. Cross-correlation with a library of supernova spectra using the Supernova Identification code (SNID; Blondin and Tonry 2007, Ap.J.

  7. VizieR Online Data Catalog: z>4.5 QSOs with SDSS and WISE. I. Opt. spectra (Wang+, 2016)

    NASA Astrophysics Data System (ADS)

    Wang, F.; Wu, X.-B.; Fan, X.; Yang, J.; Yi, W.; Bian, F.; McGreer, I. D.; Yang, Q.; Ai, Y.; Dong, X.; Zuo, W.; Jiang, L.; Green, R.; Wang, S.; Cai, Z.; Wang, R.; Yue, M.

    2016-05-01

    Optical spectroscopic observations to identify these quasar candidates were carried out using several facilities: the Lijiang 2.4m telescope (LJT) and the Xinglong 2.16m telescope in China; the Kitt Peak 2.3m Bok telescope and the 6.5m MMT telescope in the U.S.; and the 2.3m ANU telescope in Australia. (4 data files).

  8. 40 CFR 180.294 - Benomyl; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 7.0 1/1/08 Boysenberry 7.0 1/1/08 Broccoli 0.2 1/1/06 Brussels sprouts 15.0 1/1/06 Cabbage 0.2 1/1/06 Cabbage, chinese, bok choy 10.0 1/1/06 Cabbage, chinese, napa 10.0 1/1/06 Carrot, roots 0.2...

  9. Observations of Periodic Comet 2P/Encke: Physical Properties of the Nucleus and First Visual-Wavelength Detection of Its Dust Trail

    NASA Technical Reports Server (NTRS)

    Lowry, Stephen C.; Weissman, Paul R.; Sykes, Mark V.; Reach, William T.

    2003-01-01

    We are conducting an observational program designed to determine the overall distributions of size, shape, rotation period, and surface characteristics of cometary nuclei. Here, we present results from a study of the Jupiter- family comet 2P/Encke based on observations from Steward Observatory's 2.3m Bok Telescope at Kitt Peak. This comet has been observed extensively in the past and was one of the primary flyby targets of the recently failed CONTOUR mission.

  10. Submillimeter astronomy at the NASA/University of Hawaii 3-meter infrared telescope facility

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Problems encountered in the design of a submillimeter photometer for the infrared telescope facility and some of the solutions already provided are described. Observations of Saturn's rings and the determination of the brightness temperature of Titan, Jupiter, Saturn, Neptune, and Uranus are summarized. Significant findings during solar, galactic, and extragalactic observations include the discovery of low luminosity star formation in the Bok Globule B335 and determination of the far infrared properties of dust in the reflection nebula NGC 7023.

  11. Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia

    PubMed Central

    Melland-Smith, Megan; Ermini, Leonardo; Chauvin, Sarah; Craig-Barnes, Hayley; Tagliaferro, Andrea; Todros, Tullia; Post, Martin; Caniggia, Isabella

    2015-01-01

    Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress, and increased trophoblast cell death and autophagy. Maternal circulating and placental ceramide levels quantified by tandem mass spectrometry were elevated in pregnancies complicated by preeclampsia. Placental ceramides were elevated due to greater de novo synthesis via high serine palmitoyltransferase activity and reduced lysosomal breakdown via diminished ASAH1 expression caused by TGFB3-induced E2F4 transcriptional repression. SMPD1 activity was reduced; hence, sphingomyelin degradation by SMPD1 did not contribute to elevated ceramide levels in preeclampsia. Oxidative stress triggered similar changes in ceramide levels and acid hydrolase expression in villous explants and trophoblast cells. MALDI-imaging mass spectrometry localized the ceramide increases to the trophophoblast layers and syncytial knots of placentae from pregnancies complicated by preeclampsia. ASAH1 inhibition or ceramide treatment induced autophagy in human trophoblast cells via a shift of the BOK-MCL1 rheostat toward prodeath BOK. Pharmacological inhibition of ASAH1 activity in pregnant mice resulted in increased placental ceramide content, abnormal placentation, reduced fetal growth, and increased autophagy via a similar shift in the BOK-MCL1 system. Our results reveal that oxidative stress-induced reduction of lysosomal hydrolase activities in combination with elevated de novo synthesis leads to ceramide overload, resulting in increased trophoblast cell autophagy, and typifies preeclampsia as a sphingolipid storage disorder. PMID:25853898

  12. Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia.

    PubMed

    Melland-Smith, Megan; Ermini, Leonardo; Chauvin, Sarah; Craig-Barnes, Hayley; Tagliaferro, Andrea; Todros, Tullia; Post, Martin; Caniggia, Isabella

    2015-04-01

    Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress, and increased trophoblast cell death and autophagy. Maternal circulating and placental ceramide levels quantified by tandem mass spectrometry were elevated in pregnancies complicated by preeclampsia. Placental ceramides were elevated due to greater de novo synthesis via high serine palmitoyltransferase activity and reduced lysosomal breakdown via diminished ASAH1 expression caused by TGFB3-induced E2F4 transcriptional repression. SMPD1 activity was reduced; hence, sphingomyelin degradation by SMPD1 did not contribute to elevated ceramide levels in preeclampsia. Oxidative stress triggered similar changes in ceramide levels and acid hydrolase expression in villous explants and trophoblast cells. MALDI-imaging mass spectrometry localized the ceramide increases to the trophophoblast layers and syncytial knots of placentae from pregnancies complicated by preeclampsia. ASAH1 inhibition or ceramide treatment induced autophagy in human trophoblast cells via a shift of the BOK-MCL1 rheostat toward prodeath BOK. Pharmacological inhibition of ASAH1 activity in pregnant mice resulted in increased placental ceramide content, abnormal placentation, reduced fetal growth, and increased autophagy via a similar shift in the BOK-MCL1 system. Our results reveal that oxidative stress-induced reduction of lysosomal hydrolase activities in combination with elevated de novo synthesis leads to ceramide overload, resulting in increased trophoblast cell autophagy, and typifies preeclampsia as a sphingolipid storage disorder.

  13. Measurements of nitrous oxide emissions from vegetable production in China

    NASA Astrophysics Data System (ADS)

    Xiong, Zhengqin; Xie, Yingxin; Xing, Guangxi; Zhu, Zhaoliang; Butenhoff, Chris

    Nitrous oxide (N 2O) emissions resulting from Chinese vegetable production were measured. A site in suburban Nanjing (East coast; Jiangsu Province) was monitored from November 2001 to January 2003, in which five consecutive vegetable crops were sown. The crops consisted of radish, baby bok choy, lettuce, second planting of baby bok choy, and finally celery. Results suggested that N 2O emission events occur in pulses. The average N 2O-N flux for all five crops was 148±9 μg N m -2 h -1 and the average emission rate was 12±0.7 kg N ha -1. The average seasonal emission fluxes ranged from 37 μg N m -2 h -1 in the radish plot to 300 μg N m -2 h -1 in the celery plot. The celery field produced the greatest cumulative emission of 5.8 kg N ha -1 while the baby bok choy field had the lowest rate of 0.96-1.0 kg N ha -1. In total, 0.73% of applied fertilizer N was emitted as N 2O-N as a whole. The lettuce field had the largest emission factor of 2.2%. Results indicate that emissions from vegetable field are a potential source of national N 2O inventory. Temporal variation is much greater than spatial variation and the corresponding CV averaged 115% and 22%, respectively. Under the same total sampling quantity, increasing sampling frequency is more important than increasing spatial replicates.

  14. Diffusion and accumulation in cultivated vegetable plants of di-(2-ethylhexyl) phthalate (DEHP) from a plastic production factory.

    PubMed

    Du, Q Z; Wang, J W; Fu, X W; Xia, H L

    2010-08-01

    Di-(2-ethylhexyl) phthalate (DEHP) concentrations in the atmosphere and in four vegetable crops including Brassica chinensis L. (bok choy), Brassica campestris L. (field mustard), Vigna unguiculata Walp. (cowpea), and Solanum melongena L. (eggplant) cultivated on land surrounding a plastic production factory were determined. The air DEHP concentrations (means) at the sites 0.2, 0.4, 0.8, and 1.6 km away from the plastic production building were about 9.4-12.8, 5.8-9.6, 1.6-5.0, and 0.04-0.27 microg m(-3) dry weight (DW), respectively. Wind direction is a key factor influencing the measurable DEHP concentration of the air, which was highest in the downwind direction and lowest in the upwind direction, and thus the vegetables accumulated the highest DEHP contents in the downwind direction and the lowest quantities in the upwind direction. The highest DEHP accumulations content of bok choy, field mustard, eggplant, and cowpea were 52.0 +/- 3.1, 43.1 +/- 2.2, 36.2 +/- 2.8, and 19.4 +/- 0.47 mg kg(-1) DW, respectively. Safety estimation on the basis of the daily intake limit referenced by the US Environmental Protection Agency (USEPA) led to the conclusion that eating vegetables cultivated 0.2 km away from the plastic production building is not a food safety problem under normal conditions. A strong positive linear correlation between atmospheric DEHP concentration and DEHP content of the vegetable crops was found. The limits for air DEHP concentration for safe vegetable cultivation are 24.0, 34.8, 40.8, and 82.8 microg m(-3) for bok choy, field mustard, cowpea, and eggplant, respectively, by calculating from the equation of linear regression between air DEHP concentration and vegetable DEHP content.

  15. Diffusion and accumulation in cultivated vegetable plants of di-(2-ethylhexyl) phthalate (DEHP) from a plastic production factory.

    PubMed

    Du, Q Z; Wang, J W; Fu, X W; Xia, H L

    2010-08-01

    Di-(2-ethylhexyl) phthalate (DEHP) concentrations in the atmosphere and in four vegetable crops including Brassica chinensis L. (bok choy), Brassica campestris L. (field mustard), Vigna unguiculata Walp. (cowpea), and Solanum melongena L. (eggplant) cultivated on land surrounding a plastic production factory were determined. The air DEHP concentrations (means) at the sites 0.2, 0.4, 0.8, and 1.6 km away from the plastic production building were about 9.4-12.8, 5.8-9.6, 1.6-5.0, and 0.04-0.27 microg m(-3) dry weight (DW), respectively. Wind direction is a key factor influencing the measurable DEHP concentration of the air, which was highest in the downwind direction and lowest in the upwind direction, and thus the vegetables accumulated the highest DEHP contents in the downwind direction and the lowest quantities in the upwind direction. The highest DEHP accumulations content of bok choy, field mustard, eggplant, and cowpea were 52.0 +/- 3.1, 43.1 +/- 2.2, 36.2 +/- 2.8, and 19.4 +/- 0.47 mg kg(-1) DW, respectively. Safety estimation on the basis of the daily intake limit referenced by the US Environmental Protection Agency (USEPA) led to the conclusion that eating vegetables cultivated 0.2 km away from the plastic production building is not a food safety problem under normal conditions. A strong positive linear correlation between atmospheric DEHP concentration and DEHP content of the vegetable crops was found. The limits for air DEHP concentration for safe vegetable cultivation are 24.0, 34.8, 40.8, and 82.8 microg m(-3) for bok choy, field mustard, cowpea, and eggplant, respectively, by calculating from the equation of linear regression between air DEHP concentration and vegetable DEHP content. PMID:20496185

  16. Honesty in Professional Activities

    NASA Astrophysics Data System (ADS)

    Ahearne, John F.

    2012-01-01

    Honesty is an important subject in science and philosophy. Nobel Laureate Michael Bishop: "Each of us builds our discoveries on the work of others; if that work is false, our constructions fall like a house of cards and we must start all over again.” Sissela Bok has written on the pervasiveness and destructive power of lying. Not only is dishonesty corrosive to other's efforts, it corrodes the dishonest person. In most professions, respect and trust by colleagues are critical in maintaining effective working relationships. Robert Fulghum described traits that should be learned in kindergarten. These include many that seem to be lacking in today's political, economic, and communications realms.

  17. Uptake of di-(2-ethylhexyl) phthalate of vegetables from plastic film greenhouses.

    PubMed

    Fu, Xiaowei; Du, Qizhen

    2011-11-01

    Uptake of di-(2-ethylhexyl) phthalate (DEHP) of nine vegetables including potherb mustard, bok choy, celery, spinach, cabbage, leaf of tube, lettuce, garlic, and edible amaranth in plastic film greenhouses with different plastic films, film thickness, greenhouse age, and greenhouse height was studied. The results showed that the higher the DEHP content of film, the thicker the film, the lower the height of the greenhouse, and the younger the age of the greenhouse were, the higher the DEHP concentration of vegetables was. The results afford significant information for production of safe vegetables with low level DEHP contamination.

  18. Uptake of di-(2-ethylhexyl) phthalate of vegetables from plastic film greenhouses.

    PubMed

    Fu, Xiaowei; Du, Qizhen

    2011-11-01

    Uptake of di-(2-ethylhexyl) phthalate (DEHP) of nine vegetables including potherb mustard, bok choy, celery, spinach, cabbage, leaf of tube, lettuce, garlic, and edible amaranth in plastic film greenhouses with different plastic films, film thickness, greenhouse age, and greenhouse height was studied. The results showed that the higher the DEHP content of film, the thicker the film, the lower the height of the greenhouse, and the younger the age of the greenhouse were, the higher the DEHP concentration of vegetables was. The results afford significant information for production of safe vegetables with low level DEHP contamination. PMID:21958198

  19. Advanced Life Support Food Subsystem Salad Crop Requirements

    NASA Technical Reports Server (NTRS)

    Perchonok, Michele H.; Stevens, Irene; Swango, Beverly E.; Toerne, Mary E.; Lane, Helen W. (Technical Monitor)

    2002-01-01

    As the National Aeronautics and Space Administration (NASA) begins to look towards longer duration space flights, the importance of fresh foods and varied menu choices increases. Long duration space missions require development of both a Transit Food System and a Lunar or Planetary Food System. These two systems are intrinsically different since the first one will be utilized in the transit vehicle in microgravity conditions while the second will be used in conditions of partial gravity (hypogravity). The Transit Food System will consist of prepackaged food of extended shelf life. Microgravity imposes significant limitations on the ability of the crew to handle food and allows only for minimal processing. Salad crops will be available for the planetary mission. Supplementing the transit food system with salad crops is also being considered. These crops will include carrots, tomatoes, lettuce, radish, spinach, chard, cabbage, and onion. The crops will be incorporated in the menu along with the prepackaged food. The fresh tasting salad crops will provide variety, texture, and color in the menu. This variety should provide increased psychological benefit. Preliminary studies on spinach, tomatoes, and bok choy have been completed. Sensory and analytical tests, including color and moisture were conducted on the chamber grown crops and compared to store bought spinach, tomatoes, and bok choy. Preliminary studies of the appropriate serving sizes and number of servings per week have also been conducted.

  20. [N2O emission from an intensively managed greenhouse vegetable field in Nanjing suburb, Jiangsu Province of East China].

    PubMed

    Jia, Jun-Xiang; Zhang, Man; Xiong, Zheng-Qin; Li, Ye

    2012-03-01

    By using static opaque chamber and gas chromatography, this paper studied the dynamic changes of N2O fluxes and their relationships with soil temperature, soil moisture content, and soil nitrate and ammonium contents in an intensively managed greenhouse celery-Tung choy-Bok choy-amaranth rotation field and in a bare fallow land in Nanjing suburb. The cumulative N2O emission from the rotation vegetable field was as high as 137.2 kg N x hm(-2), being significantly higher than that from the bare fallow land (29.2 kg N x hm(-2)), and the N2O-N emission factor of the rotation vegetable field ecosystem was up to 4.6%. In the rotation field, the planting of Tung choy had the greatest contribution to the annual cumulative N2O emission, occupying 53.5% of the total, followed by the planting of Bok choy (31.9%), celery field (4.5%), and amaranth (4.8%). The N2O flux of the rotation field had significant positive correlation with soil temperature, the Q10 being 2.80, but no significant correlations with soil moisture content and soil nitrate and ammonium contents.

  1. [N2O emission from an intensively managed greenhouse vegetable field in Nanjing suburb, Jiangsu Province of East China].

    PubMed

    Jia, Jun-Xiang; Zhang, Man; Xiong, Zheng-Qin; Li, Ye

    2012-03-01

    By using static opaque chamber and gas chromatography, this paper studied the dynamic changes of N2O fluxes and their relationships with soil temperature, soil moisture content, and soil nitrate and ammonium contents in an intensively managed greenhouse celery-Tung choy-Bok choy-amaranth rotation field and in a bare fallow land in Nanjing suburb. The cumulative N2O emission from the rotation vegetable field was as high as 137.2 kg N x hm(-2), being significantly higher than that from the bare fallow land (29.2 kg N x hm(-2)), and the N2O-N emission factor of the rotation vegetable field ecosystem was up to 4.6%. In the rotation field, the planting of Tung choy had the greatest contribution to the annual cumulative N2O emission, occupying 53.5% of the total, followed by the planting of Bok choy (31.9%), celery field (4.5%), and amaranth (4.8%). The N2O flux of the rotation field had significant positive correlation with soil temperature, the Q10 being 2.80, but no significant correlations with soil moisture content and soil nitrate and ammonium contents. PMID:22720619

  2. Obituary: Raymond Edwin White Jr., 1933-2004

    NASA Astrophysics Data System (ADS)

    Liebert, James William

    2004-12-01

    traditions. Earlier in 1971-72, Ray served as Program Officer for Stars and Stellar Evolution in the Astronomy Section of the National Science Foundation. Ray was one of the three "originators" of "The Inspiration of Astronomical Phenomena" (INSAP) Conferences. These conferences provide scholarly discussions on the many and variegated cultural impacts of the perceptions about the day- and night-time sky, thus providing a forum for a broad sampling of artists, historians, philosophers, and scientists to get together, compare notes, and ask questions of one another. The INSAP Conferences have taken place near Castel Gandolfo Italy, on the island of Malta, near Palermo Italy, and at Oxford University in England. Ray's scholarship also was manifest in his activities as editor. For some years in the 1990s, he edited two astronomy journals, The Astronomy Quarterly and Vistas in Astronomy. Raymond E. White, Jr., is survived by his wife Ruby E. (nee Fisk), his high school sweetheart at Heidelberg High in Germany. Their children include Raymond E. White III (Professor of Physics and Astronomy at the University of Alabama, Tuscaloosa), Kathleen M. (White) Wade, and Kevin D. White. Ray was proud of two beautiful granddaughters, Charlotte R. Wade and Sarah E. Wade. Ray was proud of his early role with Steward Observatory Director Bart Bok in the commissioning of the "90-inch" reflector at the University of Arizona site on Kitt Peak in 1969. He built the direct camera, and was invited by his close friend Bok to share the "first light" of this telescope, now renamed the Bok 2.3-m telescope. When Professor Bok passed away, the astronomy magazine Sky & Telescope invited Ray to write an article which was entitled "Bart J. Bok (1906-83): Personal Memoir from a Grandson." (Bok mentored Ivan R. King, who was Ray's thesis advisor.) In his concluding remarks, Ray wrote, "The aspect of Bart J. Bok I will miss the most is his exuberance for the art of astronomy." We will also miss greatly this

  3. Methoxychlor induces atresia by altering Bcl2 factors and inducing caspase activity in mouse ovarian antral follicles in vitro.

    PubMed

    Basavarajappa, Mallikarjuna S; Karman, Bethany N; Wang, Wei; Gupta, Rupesh K; Flaws, Jodi A

    2012-12-01

    Methoxychlor (MXC) is an organochlorine pesticide widely used in many countries against various species of insects that attack crops and domestic animals. MXC reduces fertility by increasing atresia (death) of antral follicles in vivo. MXC also induces atresia of antral follicles after 96 h in vitro. The current work tested the hypothesis that MXC induces morphological atresia at early time points (24 and 48 h) by altering pro-apoptotic (Bax, Bok, Casp3, and caspase activity) and anti-apoptotic (Bcl2 and Bcl-xL) factors in the follicles. The results indicate that at 24 h, MXC increased Bcl-xL and Bax mRNA levels and increased the ratio of Bax/Bcl2. At 48-96 h, MXC induced morphological atresia. At 24-96 h, MXC increased caspase activities. These data suggest that MXC may induce atresia by altering Bcl2 factors and inducing caspase activities in antral follicles.

  4. Historical Notes on the Dutch and American-Dutch "schools" in Astronomy and Their Relations with Physics

    NASA Astrophysics Data System (ADS)

    van den Heuvel, Ed

    2006-04-01

    Dutch astronomy and physics experienced two "golden ages". The firstone covered the 17th century, culminating with Christiaan Huygens,inventor of the pendulum clock and the wave theory of light, anddiscoverer of Saturn's rings and largest satellite Titan. The secondone, which lasts till the present, started around 1880 withphysicists Lorentz, van der Waals, Zeeman and Kamerlingh Onnes andastronomer Kapteijn and his pupils De Sitter, van Rhijn, Oort andSchilt. Kapteijn, through his friendship with George Ellery Hale,initiated the strong connection between American and Dutch astronomy,which led to the rise of many Dutch-born astronomers to prominentpositions in the US, from Luyten, Bok, Brouwer, Schilt and Kuiperto Woltjer, Gehrels, and Beckers. The rise of the second "goldenage" appears to be closely related to drastic reforms in the Dutchhigh school and university systems in the last decades of the 19thcentury.

  5. Spectroscopic Classification of AT2016cvv as a normal Type Ia Supernova

    NASA Astrophysics Data System (ADS)

    Leonard, D. C.; Sheehan, P.; McCarthy, D.; Follette, K.; Moustakas, J.; Alaniz, M.; Beaumont, C.; Batterman, T.; Black, E.; Bowers, T.; Cryder, M.; Davis, C.; Dawsey, R.; Douglas, E.; Gordon, S.; Gramze, S.; Greiner, M.; Hart, K.; Holt, A.; Hu, J.; Ingebretsen, C.; Iyer, D.; Josephson, R.; Kapko, A.; Keane, J.; Kimberlin, T.; Kinman, S.; Klusmeyer, J.; Kolderup, E.; Kresina, K.; Madden, M.; Meiman, E.; Miniconi, S.; Morton, A.; Neumann, K.; Noguerra, T.; Regester, B.; Regester, J.; Rosenthal, M.; Schlingman, A.; Schlingman, W.; Schlingman, W.; Smith, A.; Svoboda, B.; Watson, L.; Whitesell, R.

    2016-06-01

    We report spectroscopic classification of AT2016cvv (also known as PTSS-16ijc), discovered 2016 June 16.709 UT by the PMO-Tsinghua Supernova Survey (PTSS) in CGCG 280-024 (z=0.044571; Falco et al. 1999, PASP 111, 438, via NED), through inspection of an optical spectrum (range 370-690 nm, resolution 0.8 nm) obtained with the 2.3-m Bok telescope (+ Boller & Chivens spectrograph) at Kitt Peak on 2016 June 19.347 UT. Cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, ApJ, 666, 1024) and GELATO (Harutyunyan et al. 2008, A & A, 488, 383) finds convincing spectral matches with a number of normal Type-Ia supernovae a few days before maximum light.

  6. Spectroscopic Classification of AT2016cvw as a normal Type Ia Supernova

    NASA Astrophysics Data System (ADS)

    Leonard, D. C.; Sheehan, P.; McCarthy, D.; Follette, K.; Moustakas, J.; Alaniz, M.; Beaumont, C.; Batterman, T.; Black, E.; Bowers, T.; Cryder, M.; Davis, C.; Dawsey, R.; Douglas, E.; Gordon, S.; Gramze, S.; Greiner, M.; Hart, K.; Holt, A.; Hu, J.; Ingebretsen, C.; Iyer, D.; Josephson, R.; Kapko, A.; Keane, J.; Kimberlin, T.; Kinman, S.; Klusmeyer, J.; Kolderup, E.; Kresina, K.; Madden, M.; Meiman, E.; Miniconi, S.; Morton, A.; Neumann, K.; Noguerra, T.; Regester, B.; Regester, J.; Rosenthal, M.; Schlingman, A.; Schlingman, W.; Schlingman, W.; Smith, A.; Svoboda, B.; Watson, L.; Whitesell, R.

    2016-06-01

    We report spectroscopic classification of AT2016cvw (also known as PTSS-16ipw), discovered 2016 June 18.813 UT by the PMO-Tsinghua Supernova Survey (PTSS) in MCG +02-58-008 (z=0.038877; Huchra et al. 2012, ApJS, 199, 26, via NED), through inspection of an optical spectrum (range 370-690 nm, resolution 0.8 nm) obtained with the 2.3-m Bok telescope (+ Boller & Chivens spectrograph) at Kitt Peak on 2016 June 20.423 UT. Cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, ApJ, 666, 1024) and GELATO (Harutyunyan et al. 2008, A & A, 488, 383) finds convincing spectral matches with a number of normal Type-Ia supernovae roughly 3 days before maximum light.

  7. The Dark Energy Spectroscopic Instrument (DESI): The NOAO DECam Legacy Imaging Survey and DESI Target Selection

    NASA Astrophysics Data System (ADS)

    Schlegel, David J.; Blum, Robert D.; Castander, Francisco Javier; Dey, Arjun; Finkbeiner, Douglas P.; Foucaud, Sebastien; Honscheid, Klaus; James, David; Lang, Dustin; Levi, Michael; Moustakas, John; Myers, Adam D.; Newman, Jeffrey; Nord, Brian; Nugent, Peter E.; Patej, Anna; Reil, Kevin; Rudnick, Gregory; Rykoff, Eli S.; Ford Schlafly, Eddie; Stark, Casey; Valdes, Francisco; Walker, Alistair R.; Weaver, Benjamin; DECam Legacy Survey Collaboration

    2015-01-01

    The DECam Legacy Survey will conduct a 3-band imaging survey of the Sloan Digital Sky Survey (SDSS) extragalactic footprint. The Dark Energy Camera (DECam) will be used to image the 6700 square degree footprint overlapping SDSS in the region -20 < Dec < +30 deg, to depths of g=24.7, r=23.9, z=23.0. The survey will be conducted from Fall 2014 through Spring 2017, with periodic data releases beginning in March 2015. These releases will include catalogs constructed with the Tractor-based multi-wavelength forced photometry applied to the DECam and WISE satellite data.The Dark Energy Spectroscopic Instrument (DESI) will observe 24 million galaxies and quasars in a 14,000 square degree extragalactic footprint. The targeting in that footprint will be provided by a combination of these DECam data, the MOSAIC camera on the Mayall 4-meter, and the 90Prime camera on the Bok Telescope.

  8. Rapid CIV BAL Variability in an SDSS-RM Quasar

    NASA Astrophysics Data System (ADS)

    Grier, Catherine; Hall, Patrick B.; Brandt, W. Niel; Trump, Jonathan; Shen, Yue; Vivek, M.

    2015-01-01

    The Sloan Digital Sky Survey Reverberation Mapping Project (SDSS-RM) recently completed its first round of spectroscopic observations of a sample of ~850 quasars with the SDSS-III BOSS spectrograph. From 2014 January-July, more than 30 epochs of spectroscopy were obtained for this quasar sample, and supporting observations were carried out at the Canada-France-Hawaii Telescope and the Steward Observatory Bok telescope. A number of quasars observed as a part of this project have broad absorption line (BAL) features in their spectra; we here report on observations of one such target that displays very rapid BAL variability --- the CIV trough is variable on rest frame timescales shorter than a few days. We will discuss the observed short-timescale variability of this BAL and the implications for the physical environment and physics regulating BALs in active galactic nuclei.

  9. Radial systems of dark globules

    SciTech Connect

    Gyul'budagyn, A.L.

    1986-03-01

    The author gives examples of radial systems consisting of dark globules and ''elephant trunks''. Besides already known systems, which contain hot stars at their center, data are given on three radial systems of a new kind, at the center of which there are stars of spectral types later than B. Data are given on 32 globules of radial systems of the association Cep OB2. On the basis of the observational data, it is concluded that at least some of the isolated Bok globules derive from elephant trunks and dark globules forming radial systems around hot stars. It is also suggested that the two molecular clouds situated near the Rosette nebula and possessing velocities differing by ca 20 km/sec from the velocity of the nebula could have been ejected in opposite directions from the center of the nebula. One of these clouds consists of dark globules forming the radial system of the Rosette nebula.

  10. Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3'-Diindolylmethane: A Therapeutic Marvel.

    PubMed

    Maruthanila, V L; Poornima, J; Mirunalini, S

    2014-01-01

    Rising evidence provides credible support towards the potential role of bioactive products derived from cruciferous vegetables such as broccoli, cauliflower, kale, cabbage, brussels sprouts, turnips, kohlrabi, bok choy, and radishes. Many epidemiological studies point out that Brassica vegetable protects humans against cancer since they are rich sources of glucosinolates in addition to possessing a high content of flavonoids, vitamins, and mineral nutrients. Indole-3-carbinol (I3C) belongs to the class of compounds called indole glucosinolate, obtained from cruciferous vegetables, and is well-known for tits anticancer properties. In particular, I3C and its dimeric product, 3,3'-diindolylmethane (DIM), have been generally investigated for their value against a number of human cancers in vitro as well as in vivo. This paper reviews an in-depth study of the anticancer activity and the miscellaneous mechanisms underlying the anticarcinogenicity thereby broadening its therapeutic marvel.

  11. Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3′-Diindolylmethane: A Therapeutic Marvel

    PubMed Central

    Maruthanila, V. L.; Poornima, J.; Mirunalini, S.

    2014-01-01

    Rising evidence provides credible support towards the potential role of bioactive products derived from cruciferous vegetables such as broccoli, cauliflower, kale, cabbage, brussels sprouts, turnips, kohlrabi, bok choy, and radishes. Many epidemiological studies point out that Brassica vegetable protects humans against cancer since they are rich sources of glucosinolates in addition to possessing a high content of flavonoids, vitamins, and mineral nutrients. Indole-3-carbinol (I3C) belongs to the class of compounds called indole glucosinolate, obtained from cruciferous vegetables, and is well-known for tits anticancer properties. In particular, I3C and its dimeric product, 3,3′-diindolylmethane (DIM), have been generally investigated for their value against a number of human cancers in vitro as well as in vivo. This paper reviews an in-depth study of the anticancer activity and the miscellaneous mechanisms underlying the anticarcinogenicity thereby broadening its therapeutic marvel. PMID:24982671

  12. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence.

    PubMed

    Kristal, Alan R; Lampe, Johanna W

    2002-01-01

    Epidemiological studies have yielded conflicting results on the associations of diet with prostate cancer. We review evidence that Brassica vegetables are associated with reduced prostate cancer risk. Brassica vegetables, which include broccoli, cabbage, mustard and collard greens, and bok choy, contain glucosinolates, the metabolic breakdown products of which are potent modulators of xenobiotic-metabolizing enzymes that protect DNA from damage. Twelve published studies give some information about Brassica vegetables and prostate cancer risk; six of these studies can be clearly interpreted. Of these, three reported statistically significant reduced risks (P < 0.05) and one reported a borderline significant reduced risk (P = 0.06) with high Brassica vegetable consumption. The epidemiological literature provides modest support for the hypothesis that high intakes of Brassica vegetables reduce prostate cancer risk.

  13. Confidentiality issues in psychological research.

    PubMed

    Peterson, C C; Siddle, D A T

    1995-11-01

    There has been increased attention in recent years to the importance of individual privacy and professional confidentiality both in Australia and overseas. At the same time, psychologists' growing research interests in areas such as AIDS, child sexual abuse, and domestic violence have led to new ethical dilemmas over the contract of confidentiality between researchers and their research participants. The present paper discusses a number of issues regarding the ethics of confidentiality in psychological research. Following Bok (1989), the issues are highlighted within the context of four ethical principles that underlie researchers' obligations to preserve confidentiality. These principles are derived from considerations of privacy, loyalty, the pledge of silence, and professional codes of ethical standards. Each of these principles is illustrated with examples taken from recent research. We devote special attention to instances that appear to provide a clash between moral principles.

  14. Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3'-Diindolylmethane: A Therapeutic Marvel.

    PubMed

    Maruthanila, V L; Poornima, J; Mirunalini, S

    2014-01-01

    Rising evidence provides credible support towards the potential role of bioactive products derived from cruciferous vegetables such as broccoli, cauliflower, kale, cabbage, brussels sprouts, turnips, kohlrabi, bok choy, and radishes. Many epidemiological studies point out that Brassica vegetable protects humans against cancer since they are rich sources of glucosinolates in addition to possessing a high content of flavonoids, vitamins, and mineral nutrients. Indole-3-carbinol (I3C) belongs to the class of compounds called indole glucosinolate, obtained from cruciferous vegetables, and is well-known for tits anticancer properties. In particular, I3C and its dimeric product, 3,3'-diindolylmethane (DIM), have been generally investigated for their value against a number of human cancers in vitro as well as in vivo. This paper reviews an in-depth study of the anticancer activity and the miscellaneous mechanisms underlying the anticarcinogenicity thereby broadening its therapeutic marvel. PMID:24982671

  15. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence.

    PubMed

    Kristal, Alan R; Lampe, Johanna W

    2002-01-01

    Epidemiological studies have yielded conflicting results on the associations of diet with prostate cancer. We review evidence that Brassica vegetables are associated with reduced prostate cancer risk. Brassica vegetables, which include broccoli, cabbage, mustard and collard greens, and bok choy, contain glucosinolates, the metabolic breakdown products of which are potent modulators of xenobiotic-metabolizing enzymes that protect DNA from damage. Twelve published studies give some information about Brassica vegetables and prostate cancer risk; six of these studies can be clearly interpreted. Of these, three reported statistically significant reduced risks (P < 0.05) and one reported a borderline significant reduced risk (P = 0.06) with high Brassica vegetable consumption. The epidemiological literature provides modest support for the hypothesis that high intakes of Brassica vegetables reduce prostate cancer risk. PMID:12235639

  16. Cygnus X-3 Little Friend's Counterpart, the Distance to Cygnus X-3 and Jets (Oh My!)

    NASA Astrophysics Data System (ADS)

    McCollough, Michael L.; Dunham, Michael M.; Corrales, Lia

    2016-04-01

    Chandra observations have revealed a feature within 16" of Cygnus X-3 which varied in phase with Cygnus X-3. This feature was shown to be a Bok globule which is along the line of sight to Cygnus X-3. We report onobservations made with Submillimeter Array (SMA) to search for molecular emission from this globule, also known as Cygnus X-3's "little friend." We have found a counterpart in both 12CO and 13CO emission. From the velocity shift of the molecular lines we are able determine a kinematic distance to the little friend and in turn a distance to Cygnus X-3. The uncertainties in this distance estimate to Cygnus X-3 are less than 10%. An additional unexpected discovery was that Cygnus X-3 is not the only source to have jets!

  17. South Galactic Cap u-band Sky Survey (SCUSS): Data Release

    NASA Astrophysics Data System (ADS)

    Zou, Hu; Zhou, Xu; Jiang, Zhaoji; Peng, Xiyan; Fan, Dongwei; Fan, Xiaohui; Fan, Zhou; He, Boliang; Jing, Yipeng; Lesser, Michael; Li, Cheng; Ma, Jun; Nie, Jundan; Shen, Shiyin; Wang, Jiali; Wu, Zhenyu; Zhang, Tianmeng; Zhou, Zhimin

    2016-02-01

    The South Galactic Cap u-band Sky Survey (SCUSS) is a deep u-band imaging survey in the south Galactic cap using the 2.3 m Bok telescope. The survey observations were completed at the end of 2013, covering an area of about 5000 square degrees. We release the data in the region with an area of about 4000 deg2 that is mostly covered by the Sloan digital sky survey. The data products contain calibrated single-epoch images, stacked images, photometric catalogs, and a catalog of star proper motions derived by Peng et al. The median seeing and magnitude limit (5σ) are about 2.″0 and 23.2 mag, respectively. There are about 8 million objects having measurements of absolute proper motions. All the data and related documentations can be accessed through the SCUSS data release website http://batc.bao.ac.cn/Uband/data.html.

  18. The development of WIFIS: a wide integral field infrared spectrograph

    NASA Astrophysics Data System (ADS)

    Sivanandam, Suresh; Chou, Richard C. Y.; Moon, Dae-Sik; Ma, Ke; Millar-Blanchaer, Maxwell; Eikenberry, Stephen S.; Chun, Moo-Young; Kim, Sang Chul; Raines, Steven N.; Eisner, Joshua

    2012-09-01

    We present the current results from the development of a wide integral field infrared spectrograph (WIFIS). WIFIS offers an unprecedented combination of etendue and spectral resolving power for seeing-limited, integral field observations in the 0.9 - 1.8 μm range and is most sensitive in the 0.9 - 1.35 μ,m range. Its optical design consists of front-end re-imaging optics, an all-reflective image slicer-type, integral field unit (IFU) called FISICA, and a long-slit grating spectrograph back-end that is coupled with a HAWAII 2RG focal plane array. The full wavelength range is achieved by selecting between two different gratings. By virtue of its re-imaging optics, the spectrograph is quite versatile and can be used at multiple telescopes. The size of its field-of-view is unrivalled by other similar spectrographs, offering a 4.511x 1211 integral field at a 10-meter class telescope (or 2011 x 5011 at a 2.3-meter telescope). The use of WIFIS will be crucial in astronomical problems which require wide-field, two-dimensional spectroscopy such as the study of merging galaxies at moderate redshift and nearby star/planet-forming regions and supernova remnants. We discuss the final optical design of WIFIS, and its predicted on-sky performance on two reference telescope platforms: the 2.3-m Steward Bok telescope and the 10.4-m Gran Telescopio Canarias. We also present the results from our laboratory characterization of FISICA. IFU properties such as magnification, field-mapping, and slit width along the entire slit length were measured by our tests. The construction and testing of WIFIS is expected to be completed by early 2013. We plan to commission the instrument at the 2.3-m Steward Bok telescope at Kitt Peak, USA in Spring 2013.

  19. The Mayall z-band Legacy Survey

    NASA Astrophysics Data System (ADS)

    Silva, David R.; Blum, Robert D.; Allen, Lori; Dey, Arjun; Schlegel, David J.; Lang, Dustin; Moustakas, John; Meisner, Aaron M.; Valdes, Francisco; Patej, Anna; Myers, Adam D.; Sprayberry, David; Saha, Abi; Olsen, Knut A.; Safonova, Sasha; Yang, Qian; Burleigh, Kaylan J.; MzLS Team

    2016-06-01

    The Mayall z-band Legacy Survey (MzLS) is conducting a deep z-band imaging survey covering 5000 square degrees in the north Galactic cap as part of the Legacy Survey, which is associated with the Dark Energy Spectroscopic Instrument (DESI) redshift survey. The Legacy Survey covers 14000 square degrees in the g, r, and z bands and is being executed on the Blanco 4-m, Mayall 4-m, and Bok 2.3-m telescopes. The MzLS footprint will be observed in the g and r bands using the Bok 2.3-m telescope also on Kitt Peak. The Beijing Arizona Sky Survey (BASS) is being conducted by a parallel team from Beijing and the University of Arizona. MzLS will cover the sky north of declination 30 degrees and reach a depth of z=23.0. The survey began in January 2016 and will run through June 2017 comprising approximately 230 nights on the Mayall telescope. The data are being obtained with an upgraded Mosaic camera that deploys with newred-sensitive CCDs from Lawrence Berkeley Lab (LBL) whose throughput is in excess of 80% at 8000 to approximately 9800 Angstrom. The upgrade project was a collaboration of Yale, LBL, and NOAO. MzLS images are public as soon as they are taken and delivered to the NOAO archive. Catalogs based on Tractor photometry for all available Legacy Survey images are released soon after they are constructed and MzLS sources will be included in next release planned for summer 2016. The Dark Energy Spectroscopic Instrument (DESI) will observe 30+ million galaxies and quasars in a 14,000 square degree extragalactic footprint. The targeting in that footprint will be provided by a combination of these MzLS data, DECam data from the DECam Legacy Survey, and data from the BASS survey.

  20. 2 Millimeter Observations of Bright-rimmed Clouds with IRAS Point Sources

    NASA Astrophysics Data System (ADS)

    Sugitani, K.; Matsuo, H.; Nakano, M.; Tamura, M.; Ogura, K.

    2000-01-01

    We have made 2 mm continuum observations of 15 bright-rimmed clouds (BRCs) associated with IRAS point sources and S140 with the Nobeyama Bolometer Array (NOBA) mounted on the 45 m telescope of Nobeyama Radio Observatory. Continuum emission was detected in five BRCs and in S140. These five BRCs are known to be associated with near-infrared YSO clusters, mostly on the side facing toward the exciting star(s) and, therefore, are likely the sites of small-scale sequential star formation. The detected emission peaks of these five sources correspond to the IRAS positions within the positional errors, and the IRAS sources are considered to be protostars (Class 0/I-like sources) that were formed most recently in the BRCs. Four of them are clearly extended more than the telescope beam, suggesting the presence of circumstellar structures. The circumstellar masses derived from the 2 mm continuum are ~5-90 Msolar, which are more massive than those of the nearby Class 0/I objects (<~1 Msolar). This fact and the relatively large bolometric luminosities of these objects suggest that the mass of the cluster or star(s) most recently formed in these BRCs could be higher than those of the previously formed stars found in the near-infrared cluster. The comparisons with previous observations of Bok globules unassociated with bright rims and other objects are discussed. Most noteworthy is that the ratios of the bolometric luminosity to the circumstellar mass are significantly higher for these BRCs than for Bok globules.

  1. Cisplatin Inhibits Hippocampal Cell Proliferation and Alters the Expression of Apoptotic Genes

    PubMed Central

    Manohar, Senthilvelan; Jamesdaniel, Samson; Salvi, Richard

    2014-01-01

    The hippocampus, which is critical for memory and spatial navigation, contains a proliferating stem cell niche that is especially vulnerable to anti-neoplastic drugs such as cisplatin. Although the damaging effects of cisplatin have recently been recognized, the molecular mechanisms underlying its toxic effects on this vital region are largely unknown. Using a focused apoptosis gene array, we analyzed the early cisplatin-induced changes in gene expression in the hippocampus of adult Sprague-Dawley rats and compared the results to those from the inferior colliculus, a non-mitotic auditory region resistant to cisplatin-induced cell death. Two days after a 12 mg/kg dose of cisplatin, significant increases were observed in five proapoptotic genes Bik, Bid, Bok, Trp53p2 and Card6 and a significant decrease in one antiapoptotic gene Bcl2a1. In contrast, Nol3, an antiapoptotic gene showed a significant increase in expression. The cisplatin-induced increase in Bid mRNA and decrease in Bcl2a1 mRNA was accompanied by a corresponding increase and decrease of their respective proteins in the hippocampus. In contrast, the cisplatin-induced changes in Bcl2a1, Bid, Bik and Bok gene expression in the inferior colliculus were strikingly different from those in the hippocampus consistent with the greater susceptibility of the hippocampus to cisplatin toxicity. Cisplatin also significantly reduced immunolabeling of the cell proliferation marker Ki67 in the subgranular zone (SGZ) of the hippocampus two days post treatment. These results indicate that cisplatin-induced hippocampal cell death is mediated by increased expression of proapoptotic and antiapoptotic genes and proteins that likely inhibit hippocampal cell proliferation. PMID:24277158

  2. Synoptic Observations for Physical Characterization of Fast Rotator NEOs

    NASA Astrophysics Data System (ADS)

    Kikwaya Eluo, Jean-Baptiste; Hergenrother, Carl W.

    2014-11-01

    NEOs can be studied not only dynamically, to learn about their impact hazard, but also physically, to establish various properties important both to better address their potential hazard and also to understand what they can tell us about the origin of the solar system and its ongoing processes.Taking advantage of the two-meter-class telescopes around Tucson, we plan to observe NEOs synoptically using telescopes at three different locations: VATT (Vatican Advanced Technology Telescope) at Mount Graham (longitude: -109.8719, latitude: 32.7016, elevation: 10469 feet), Bok 2.3 m at Kitt Peak (longitude: -111.6004, latitude: 31.9629, elevation: 6795 feet) and Kuiper 1.5-m at Mount Bigelow (longitude: -110.7345, latitude: 32.4165, elevation: 8235 feet). All three telescopes will aim simultaneously at the same object, each with a different instrument. The three telescopes will be part of the Arizona Robotic Telescope (ART) network, a University of Arizona initiative to provide near real-time observations of Target of Opportunity objects across the visible and near-infrared wavelengths. The VATT-4K optical imager mounted on the VATT has already been used for photometry. In the future we plan to utilize the BCSpec (Boller & Chivens Spectrograph) for visible spectroscopy on Bok 2.3 meter and a near-infrared instrument on Kuiper 1.5 meter. We report here the preliminary results of several NEOs whose rotation rate and color have been estimated using photometry with images recorded with VATT-4K. 2009 SQ104 has a rotation rate of 6.85+/- 0.03 h, 2014 AY28 has a rotation rate of 0.91 +/- 0.02 h, 2014 EC of 0.54 +/-0.04 h, 2014 FA44 of 3.45 +/- 0.05 h, and 2014 KS40 of 1.11 +/- 0.06 h.

  3. The DECam Legacy Survey

    NASA Astrophysics Data System (ADS)

    Blum, Robert D.; Burleigh, Kaylan; Dey, Arjun; Schlegel, David J.; Meisner, Aaron M.; Levi, Michael; Myers, Adam D.; Lang, Dustin; Moustakas, John; Patej, Anna; Valdes, Francisco; Kneib, Jean-Paul; Huanyuan, Shan; Nord, Brian; Olsen, Knut A.; Delubac, Timothée; Saha, Abi; James, David; Walker, Alistair R.; DECaLS Team

    2016-06-01

    The DECam Legacy Survey (DECaLS) is conducting a 3-band imaging survey of the Sloan Digital Sky Survey (SDSS) extragalactic footprint as part of the Legacy Survey, which is associated with the Dark Energy Spectroscopic Instrument (DESI) redshift survey. The Legacy Survey covers 14000 square degrees in the g, r, and z bands and is being executed on the Blanco 4-m, Mayall 4-m, and Bok 2.3-m telescopes. For DECaLS, the Dark Energy Camera (DECam) will image the footprint overlapping SDSS in the region -20 < Dec < +30 deg, to depths of g=24.7, r=23.9, z=23.0 and will eventually cover a total of 7500 square degrees. The survey began in 2014 and will run through Spring 2017. Images and catalogs were introduced in Public Data Release 2 (DR2), which occurred in January 2016. The algorithm "Tractor" applies multi-wavelength forced photometry to DECam and WISE data to produce galaxy (and star) magnitudes (as well as shape and other information) for the catalogs. In total, the optical data in DR2 cover a disjoint footprint in 2078, 2141 and 5322 square degrees in g, r, and z bands, respectively; 1807 square degrees has been observed in all three optical filters. There are approximately 260 million unique sources in DR2 spread over 97,554 0.25 x 0.25 square degree bricks.The Dark Energy Spectroscopic Instrument (DESI) will observe 30+ million galaxies and quasars in a 14,000 square degree extragalactic footprint. The targeting in that footprint will be provided by a combination of these DECam data, the MOSAIC camera on the Mayall 4-meter, and the 90Prime camera on the Bok telescope.

  4. Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats.

    PubMed

    Govindaraj, Vijayakumar; Rao, A Jagannadha

    2015-01-01

    Age related decline in reproductive performance in women is well documented and apoptosis has been considered as one of the reasons for the decline of primordial follicle reserve. Recently we observed a decline in the efficiency of DNA repair ability in aged rat primordial follicles as demonstrated by decreased mRNA levels of DNA repair genes BRCA1 and H2AX. In the present study, a two-dimensional electrophoresis (2DE) proteomic approach was employed to identify differentially expressed proteins in primordial follicles isolated from ovaries of immature (∼20 days) and aged (∼400-450 days) rats. Using MALDI-TOF/TOF MS, we identified 13 differentially expressed proteins (p < 0.05) which included seven up-regulated and six down-regulated proteins in aged primordial follicles. These proteins are involved in a wide range of biological functions including apoptosis, DNA repair, and the immune system. Interestingly, the differentially expressed proteins such as FIGNL1 (DNA repair) and BOK (apoptotic protein) have not been previously reported in the rat primordial follicles and these proteins can be related to some common features of ovarian aging such as loss of follicle reserve and genome integrity. The quantitative differences of two important proteins BOK and FIGNL1 observed by the proteomic analysis were correlated with the transcript levels, as determined by semi-quantitative RT-PCR. Our results improve the current knowledge about protein factors associated with molecular changes in rat primordial follicles as a function of aging and our understanding of the proteomic processes involved in degenerative changes observed in aging primordial follicles. PMID:26391928

  5. Sound-triggered collapse of stably oscillating low-mass cores in a two-phase interstellar medium

    NASA Astrophysics Data System (ADS)

    Zhang, Ui-Han; Schive, Hsi-Yu; Chiueh, Tzihong

    2015-05-01

    Inspired by Barnard 68, a Bok globule, that undergoes stable oscillations, we perform multiphase hydrodynamic simulations to analyse the stability of Bok globules. We show that a high-density soft molecular core, with an adiabatic index γ = 0.7 embedded in a warm isothermal diffuse gas, must have a small density gradient to retain the stability. Despite being stable, the molecular core can still collapse spontaneously as it will relax to develop a sufficiently large density gradient after tens of oscillations, or a few 107 yr. However, during its relaxation, the core may abruptly collapse triggered by the impingement of small-amplitude, long-wavelength (˜6-36 pc) sound waves in the warm gas. This triggered collapse mechanism is similar to a sonoluminescence phenomenon, where underwater ultrasounds can drive air bubble coalescence. The collapse configuration is found to be different from both inside-out and outside-in models of low-mass star formation; none the less the mass flux is close to the prediction of the inside-out model. The condition and the efficiency for this core collapse mechanism are identified. Generally speaking, a broad-band resonance condition must be met, where the core oscillation frequency and the wave frequency should match each other within a factor of several. A consequence of our findings predicts the possibility of propagating low-mass star formation, for which collapse of cores, within a mass range short of one order of magnitude, takes place sequentially tracing the wavefront across a region of few tens of pc over 107 yr.

  6. Scientists Look at 2010: Carrying on Margaret Mayall's Legacy of Debunking Pseudoscience

    NASA Astrophysics Data System (ADS)

    Larsen, Krinstine

    2010-06-01

    In 1941 Margaret Mayall, the future director of the AAVSO, and Harvard colleague Bart Bok authored a critical study of astrology and its impact on society entitled "Scientists Look at Astrology." They chastised the scientific community for thinking the debunking of astrology to be "below the dignity of scientists." In contrast, they opined that it is one of the duties of scientists to "inform the public about the nature and background of a current fad, such as astrology, even though to do so may be unpleasant." Fast-forward 68 years in the future, and the astronomical community now faces a pseudoscientific enemy just as insidious as astrology, yet just as ignored by the general professional and amateur community as astrology had been when Mayall and Bok took up the charge in 1941. The pseudoscience in question is the well-publicized "prediction" that the Mayan calendar will end on December 21, 2012, causing the end of civilization in concert with one of a number of possible astronomical calamities, including (but not limited to) the gravitational pull of the center of the Milky Way (somehow enhanced by an "alignment" with our solar system), the near-approach by a mythical 10th planet (often named Nibiru), large-scale damage to the planet by solar flares larger than those ever recorded, or the shifting of the earth's axis of rotation (often confused with a proposed sudden and catastrophic reversal of the earth's magnetic polarity). As a scientific and educational organization, the AAVSO and its members have a responsibility to follow in Mayall's footsteps, shining the light of reason and knowledge on the dark corners of ignorance which far too often permeate the Internet, radio and television programming, and recent films, most notably 2012. This talk will highlight some of the basic premises of the 2012 hysteria and suggest ways that the AAVSO and its members can use variable stars and the history of the AAVSO to counteract some of the astronomical misinformation

  7. HUBBLE SNAPSHOT CAPTURES LIFE CYCLE OF STARS

    NASA Technical Reports Server (NTRS)

    2002-01-01

    In this stunning picture of the giant galactic nebula NGC 3603, the crisp resolution of NASA's Hubble Space Telescope captures various stages of the life cycle of stars in one single view. To the upper right of center is the evolved blue supergiant called Sher 25. The star has a unique circumstellar ring of glowing gas that is a galactic twin to the famous ring around the supernova 1987A. The grayish-bluish color of the ring and the bipolar outflows (blobs to the upper right and lower left of the star) indicates the presence of processed (chemically enriched) material. Near the center of the view is a so-called starburst cluster dominated by young, hot Wolf-Rayet stars and early O-type stars. A torrent of ionizing radiation and fast stellar winds from these massive stars has blown a large cavity around the cluster. The most spectacular evidence for the interaction of ionizing radiation with cold molecular-hydrogen cloud material are the giant gaseous pillars to the right and lower left of the cluster. These pillars are sculptured by the same physical processes as the famous pillars Hubble photographed in the M16 Eagle Nebula. Dark clouds at the upper right are so-called Bok globules, which are probably in an earlier stage of star formation. To the lower left of the cluster are two compact, tadpole-shaped emission nebulae. Similar structures were found by Hubble in Orion, and have been interpreted as gas and dust evaporation from possibly protoplanetary disks (proplyds). The 'proplyds' in NGC 3603 are 5 to 10 times larger in size and correspondingly also more massive. This single view nicely illustrates the entire stellar life cycle of stars, starting with the Bok globules and giant gaseous pillars, followed by circumstellar disks, and progressing to evolved massive stars in the young starburst cluster. The blue supergiant with its ring and bipolar outflow marks the end of the life cycle. The color difference between the supergiant's bipolar outflow and the diffuse

  8. Spacewatch Observations of Near-Earth Objects

    NASA Astrophysics Data System (ADS)

    McMillan, Robert S.; Larsen, Jeffrey A.; Bressi, Terrence H.; Scotti, James V.; Mastaler, Ronald A.; Tubbiolo, Andrew F.

    2015-08-01

    Spacewatch specializes in followup of NEOs of high priority while they are faint, producing an annual average of ~8500 lines of astrometry of ~1,000 different NEOs. We contribute to the removal of half of the objects that were retired from impact risk lists. Our observations at elongations as small as 46 deg support followup of hazardous NEOs and NEOs discovered by the NEOWISE spacecraft. Per year we observe about 35 radar targets, 50 NEOs that were measured by NEOWISE, and 100 potential rendezvous destinations. In the last 3 years we have observed 50% of all NEOs observed in that time and 54% of all PHAs observed in that time. We lead in followup of provisionally designated PHAs while faint (V>= 22); contributing 41% of all such observations. With the Steward Obs. 0.9-m telescope, site code 691, we survey with a mosaic of CCDs near opposition and at low elongation in the east. Coverage is 1400 sq. deg per lunation; V mag limit ~20.5-21.7. The 12 yrs of uniform surveying will go live on the web in 2015 to support incidental astrometry & precoveries of NEOs. On the Spacewatch 1.8-m telescope, site code 291, the FOV = 20x20 arcmin and the pixel scale = 0.6 arcsec/pixel. V mag limit=23 and the astrometric residuals are +/-0.3 arcsec. Our output with the Bok 2.3-m & Mayall 4-m telescopes from 2010-2014 was 1316 lines of astrometry on 207 different NEOs, including 84 different PHAs. 343 observations were made of PHAs with V>=22. Our average calendar span extension on large PHAs is 6 mo, 2x longer than the next most effective observing station. We extend the span of calendar time coverage on PHAs an average of 3.8x. For 38 of 72 PHAs we added another observed opposition. With the Bok & Mayall we reduce uncertainties of orbital elements an average of a factor of 6 and the uncertainty of the time of perihelion passage an average of a factor of 19 (G. Williams 2014 private communication). We gratefully acknowledge NASA's NEO Observation Program, The IAU's Minor Planet

  9. Multicolor photometry of the merging galaxy cluster A2319: Dynamics and star formation properties

    SciTech Connect

    Yan, Peng-Fei; Yuan, Qi-Rong; Zhang, Li; Zhou, Xu E-mail: yuanqirong@njnu.edu.cn

    2014-05-01

    Asymmetric X-ray emission and a powerful cluster-scale radio halo indicate that A2319 is a merging cluster of galaxies. This paper presents our multicolor photometry for A2319 with 15 optical intermediate filters in the Beijing-Arizona-Taiwan-Connecticut (BATC) system. There are 142 galaxies with known spectroscopic redshifts within the viewing field of 58' × 58' centered on this rich cluster, including 128 member galaxies (called sample I). A large velocity dispersion in the rest frame, 1622{sub −70}{sup +91} km s{sup –1}, suggests merger dynamics in A2319. The contour map of projected density and localized velocity structure confirm the so-called A2319B substructure, at ∼10' northwest to the main concentration A2319A. The spectral energy distributions (SEDs) of more than 30,000 sources are obtained in our BATC photometry down to V ∼ 20 mag. A u-band (∼3551 Å) image with better seeing and spatial resolution, obtained with the Bok 2.3 m telescope at Kitt Peak, is taken to make star-galaxy separation and distinguish the overlapping contamination in the BATC aperture photometry. With color-color diagrams and photometric redshift technique, 233 galaxies brighter than h {sub BATC} = 19.0 are newly selected as member candidates after an exclusion of false candidates with contaminated BATC SEDs by eyeball-checking the u-band Bok image. The early-type galaxies are found to follow a tight color-magnitude correlation. Based on sample I and the enlarged sample of member galaxies (called sample II), subcluster A2319B is confirmed. The star formation properties of cluster galaxies are derived with the evolutionary synthesis model, PEGASE, assuming a Salpeter initial mass function and an exponentially decreasing star formation rate (SFR). A strong environmental effect on star formation histories is found in the manner that galaxies in the sparse regions have various star formation histories, while galaxies in the dense regions are found to have shorter SFR time

  10. A Systems Engineering Approach to Quality Assurance for Aerospace Testing

    NASA Technical Reports Server (NTRS)

    Shepherd, Christena C.

    2015-01-01

    On the surface, it appears that AS91001 has little to say about how to apply a Quality Management System (QMS) to major aerospace test programs (or even smaller ones). It also appears that there is little in the quality engineering Body of Knowledge (BOK)2 that applies to testing, unless it is nondestructive examination (NDE), or some type of lab or bench testing associated with the manufacturing process. However, if one examines: a) how the systems engineering (SE) processes are implemented throughout a test program; and b) how these SE processes can be mapped to the requirements of AS9100, a number of areas for involvement of the quality professional are revealed. What often happens is that quality assurance during a test program is limited to inspections of the test article; what could be considered a manufacturing al fresco approach. This limits the quality professional and is a disservice to the programs and projects, since there are a number of ways that quality can enhance critical processes, and support efforts to improve risk reduction, efficiency and effectiveness.

  11. Expression and Critical Role of Interleukin Enhancer Binding Factor 2 in Hepatocellular Carcinoma

    PubMed Central

    Cheng, Shaobing; Jiang, Xu; Ding, Chaofeng; Du, Chengli; Owusu-Ansah, Kwabena Gyabaah; Weng, Xiaoyu; Hu, Wendi; Peng, Chuanhui; Lv, Zhen; Tong, Rongliang; Xiao, Heng; Xie, Haiyang; Zhou, Lin; Wu, Jian; Zheng, Shusen

    2016-01-01

    Interleukin enhancer binding factor 2 (ILF2), a transcription factor, regulates cell growth by inhibiting the stabilization of mRNA. Currently, its role has gained recognition as a factor in the tumorigenic process. However, until now, little has been known about the detailed role ILF2 plays in hepatocellular carcinoma (HCC). In this study, we investigated the expression levels of ILF2 in HCC tissue with Western blot and immunohistochemical assays. To examine the effect of ILF2 on liver cancer cell growth and apoptosis, small interfering RNAs (siRNAs) targeting ILF2 were recombined to create lentiviral overexpression vectors. Our results showed higher expression levels of ILF2 mRNA and ILF2 protein in HCC tissue compared with matched peritumoral tissue. Expression of ILF2 may regulate cell growth and apoptosis in liver cancer cells via regulation of B-cell lymphoma 2 (Bcl-2), Bcl-2 related ovarian killer (Bok), Bcl-2-associated X protein (BAX), and cellular inhibitor of apoptosis 1 (cIAP1). Moreover, we inoculated nude mice with liver cancer cells to investigate the effect of ILF2 on tumorigenesis in vivo. As expected, a rapid growth was observed in cancer cells inoculated with a lentiviral vector coding Flag-ILF2 (Lenti-ILF2) compared with the control cells. Hence, these results promote a better understanding of ILF2’s potential role as a therapeutic target in HCC. PMID:27556459

  12. Screening for beneficial effects of oral intake of sweet corn by DNA microarray analysis.

    PubMed

    Tokuji, Yoshihiko; Akiyama, Kyoko; Yunoki, Keita; Kinoshita, Mikio; Sasaki, Keiko; Kobayashi, Hitoshi; Wada, Masahiro; Ohnishi, Masao

    2009-09-01

    To identify novel functions of the oral intake of sweet corn, we performed DNA microarray analysis of the livers of sweet corn-fed mice. Functional annotation clustering 1600 genes with expression levels that were affected (more than 1.5-fold change) by dietary sweet corn indicated that both cell proliferation and programmed cell death were modulated by sweet corn intake. In the Wnt signaling pathway, which is involved in cell proliferation, the levels of Jun and beta-catenin expression were downregulated by dietary sweet corn. The mRNA levels of Rb and p53, negative regulators of the cell cycle, were increased in mice fed with sweet corn. Dietary corn upregulated expression levels of genes that regulate apoptosis positively (for example, BOK, BID, CASP4). These results suggested that sweet corn is a valuable food for suppressing cancer. Oral administration of sweet corn inhibited tumor growth (36.6% reduce in tumor weight, P < 0.05) in mice inoculated with Ehrlich tumor cells. PMID:19895470

  13. DA White Dwarfs in the Kepler Field

    NASA Astrophysics Data System (ADS)

    Doyle, T. F.; Howell, S. B.; Petit, V.; Lépine, S.

    2016-10-01

    We present 16 new, and confirm 7 previously identified, DA white dwarfs in the Kepler field through ground-based spectroscopy with the Hale 200″, Kitt Peak 4-meter, and Bok 2.3-meter telescopes. Using atmospheric models we determine their effective temperatures and surface gravities to constrain their position with respect to the ZZ Ceti (DA pulsator) instability strip, and look for the presence or absence of pulsation with Kepler's unprecedented photometry. Our results are as follows: i) From our measurements of temperature and surface gravity, 12 of the 23 DA white dwarfs from this work fall well outside of the instability strip. The Kepler photometry available for 11 of these WDs allows us to confirm that none are pulsating. One of these eleven happens to be a presumed binary, KIC 11604781, with a period of ˜5 days. ii) The remaining 11 DA white dwarfs are instability strip candidates, potentially falling within the current, empirical instability strip, after accounting for uncertainties. These WDs will help constrain the strip's location further, as eight are near the blue edge and three are near the red edge of the instability strip. Four of these WDs do not have Kepler photometry, so ground-based photometry is needed to determine the pulsation nature of these white dwarfs. The remaining seven have Kepler photometry available, but do not show any periodicity on typical WD pulsation timescales.

  14. Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue.

    PubMed

    Piotrowska, Hanna; Myszkowski, Krzysztof; Amarowicz, Ryszard; Murias, Marek; Kulcenty, Katarzyna; Wierzchowski, Marcin; Jodynis-Liebert, Jadwiga

    2013-12-01

    The cytotoxic activity of DMU-212 has been shown to vary in cell lines derived from the same type of cancer, i.e. ovarian, breast and colorectal ones. However, the molecular mechanism of DMU-212 cytotoxicity has not been clarified in colon cancer cells. This study aims to elucidate the mechanism of antitumor effects of DMU-212 in two human colon cancer cell lines, DLD-1 and LOVO. We showed the stronger cytotoxic activity in DLD-1 cells in which DMU-212 evoked a greater pro-apoptotic effect as compared to that of LOVO cells. The analysis of the expression pattern of 84 apoptosis-related genes indicated transcripts specific to the mitochondria-mediated apoptosis pathway in both colon cancer cell lines used. We found that DMU-212 caused up-regulation of pro-apoptotic Bak1, Bok, Bik, Noxa, Bad, Bax, p53 and Apaf1 transcripts level in DLD-1 cell line, whereas anti-apoptotic Bcl-2, Bcl-xL and Bag1 mRNA expression was decreased. Changes in apoptosis-related genes expression were less pronounced in LOVO cells which did not express CYP1B1 protein and showed lower expression of CYP1A1 protein level than that in DLD-1 cells. Our results suggest that anticancer activity of DMU-212 is closely related to its biotransformation catalysed by these cytochrome P450 isoenzymes.

  15. Cygnus X-3: Its Little Friend’s Counterpart, the Distance to Cygnus X-3, and Outflows/Jets

    NASA Astrophysics Data System (ADS)

    McCollough, M. L.; Corrales, L.; Dunham, M. M.

    2016-10-01

    Chandra observations have revealed a feature within 16″ of Cygnus X-3 that varied in phase with Cygnus X-3. This feature was shown to be a Bok globule that is along the line of sight to Cygnus X-3. We report on observations made with the Submillimeter Array to search for molecular emission from this globule, also known as Cygnus X-3's “Little Friend.” We have found a counterpart in both 12CO (2-1) and 13CO (2-1) emission. From the velocity shift of the molecular lines we are able to find two probable distances based on the Bayesian model of Milky Way kinematics of Reid et al. For the LF velocity of ‑47.5 km s‑1, we find distances of 6.1 ± 0.6 kpc (62% probability) and 7.8 ± 0.6 kpc (38% probability). This yields distances to Cyg X-3 of 7.4 ± 1.1 kpc and 10.2 ± 1.2 kpc, respectively. Based on the probabilities entailed, we take 7.4 ± 1.1 kpc as the preferred distance to Cyg X-3. We also report the discovery of bipolar molecular outflow, suggesting that there is active star formation occurring within the Little Friend.

  16. Far infrared, near infrared, and radio molecular line studies of HFE 2, HFE 3, and FJM 6

    NASA Technical Reports Server (NTRS)

    Fischer, J.; Cassar, L.; Righini-Cohen, G.; Simon, M.

    1979-01-01

    Far-infrared, near-infrared, and radio molecular-line observations of the regions of HFE 2, HFE 3, and FJM 6 are described. At positions of high molecular column density nearest to the reported positions of these sources, their infrared emission cannot be confirmed at upper bounds below those of the original detection. Near-infrared observations of the FJM 6 region (which includes the Bok globule Barnard 361) reveal a number of stellar sources, most of which are behind the molecular cloud and are reddened by it. Visual extinction through B 361 estimated by star counts yields A sub V/N(/C-13/O) = 3.7 + or - 1.6) x 10 to the -16th mag sq cm. The gas temperature and the upper bound on the dust temperature in the FJM 6 region are consistent with cosmic-ray heating of the cloud, while the values of these parameters for the clouds in the HFE 2 and HFE 3 regions do not appear consistent with either cosmic-ray or radiative heating.

  17. Wide Integral Field Infrared Spectroscopic Survey of Nearby Galaxies

    NASA Astrophysics Data System (ADS)

    Sivanandam, Suresh; Moon, Dae-Sik; Zaritsky, Dennis F.; Chou, Richard; Meyer, Elliot; Ma, Ke; Jarvis, Miranda; Eisner, Joshua A.

    2015-01-01

    We are constructing a novel infrared integral field spectrograph with a large field of view (~50'x20') that will be available on the Kitt Peak 90' Bok telescope this spring. This wide integral field infrared spectrograph (WIFIS) operates over two wavelength ranges, zJ-band (0.9-1.35 microns) and H-band (1.5-1.8 microns), and has moderate spectral resolving power, 3,000 in zJ-band and 2,200 in H-band, respectively. WIFIS' field-of-view is comparable to current optical integral field spectrographs that are carrying out large galaxy surveys, e.g. SAMI, CALIFA, and MaNGA. We are designing a large nearby galaxy survey to complement the data already been taken by these optical integral field spectroscopic surveys. The near-infrared window provides a sensitive probe of the initial mass functions of stellar populations, the OB stellar fractions in massive star forming regions, and the kinematics of and obscured star formation within merging systems. This will be the first large scale infrared integral field spectroscopic survey of nearby galaxies.

  18. Crimson Tide: The Harvard Books on Astronomy

    NASA Astrophysics Data System (ADS)

    Lindner, R. P.

    2001-12-01

    The Harvard Books on Astronomy, a series of crimson clad, fully illustrated volumes, cornered, for more than a generation, the market of readers interested in astronomy. A large number of astronomers owe their first serious initiation to the literature of astronomy to these books. Their style, presentation, design, and tone marked a clear departure from the inherited traditions in the field. Each summed up a field, awarded points for merit, and staked out paths for future study. No doubt each of the more mature readers of this abstract has his or her favorite volume, and even his or her own favorite edition of a particular volume. How the volumes evolved and what happened to the series with Harlow Shapley's retirement are not only questions in the history of the book but also form a commentary on the standards of scientific writing for the educated public. For this the major evidence comes from the volumes by Shapley himself, Leo Goldberg and Lawrence Aller, and the Boks. This paper discusses the origins of the series, the purpose of the works, the varying successes of the volumes, and the impact they had on the future astronomical community. In part, this is a contribution to the impact of Harlow Shapley upon the wider field and the role of Harvard in the American astronomical community. It is also a meditation upon the ways of recruitment into the field and forming ways of looking at research problems.

  19. The effectiveness of spent coffee grounds and its biochar on the amelioration of heavy metals-contaminated water and soil using chemical and biological assessments.

    PubMed

    Kim, Min-Suk; Min, Hyun-Gi; Koo, Namin; Park, Jeongsik; Lee, Sang-Hwan; Bak, Gwan-In; Kim, Jeong-Gyu

    2014-12-15

    Spent coffee grounds (SCG) and charred spent coffee grounds (SCG-char) have been widely used to adsorb or to amend heavy metals that contaminate water or soil and their success is usually assessed by chemical analysis. In this work, the effects of SCG and SCG-char on metal-contaminated water and soil were evaluated using chemical and biological assessments; a phytotoxicity test using bok choy (Brassica campestris L. ssp. chinensis Jusl.) was conducted for the biological assessment. When SCG and SCG-char were applied to acid mine drainage, the heavy metal concentrations were decreased and the pH was increased. However, for SCG, the phytotoxicity increased because a massive amount of dissolved organic carbon was released from SCG. In contrast, SCG-char did not exhibit this phenomenon because any easily released organic matter was removed during pyrolysis. While the bioavailable heavy metal content decreased in soils treated with SCG or SCG-char, the phytotoxicity only rose after SCG treatment. According to our statistical methodology, bioavailable Pb, Cu and As, as well as the electrical conductivity representing an increase in organic content, affected the phytotoxicity of soil. Therefore, applying SCG during environment remediation requires careful biological assessments and evaluations of the efficiency of this remediation technology.

  20. Growth inhibition in Chinese cabbage (Brassica rapa var. chinensis) growth exposed to di-n-butyl phthalate.

    PubMed

    Liao, Chien-Sen; Yen, Jui-Hung; Wang, Yei-Shung

    2009-04-30

    The toxicity and effects of di-n-butyl phthalate (DBP), an endocrine disruptor, on the growth of Chinese cabbage (Brassica rapa var. chinensis) were studied. Etiolation occurred on leaves of Chinese cabbage plant treated with 50mg/L of DBP for 42 d. DBP even below 1mg/L had a significant effect on the concentration of chlorophyll in Chinese cabbage and the biomass showed a severe decrease under treatment with more than 30 mg/L of DBP. At a concentration below 1mg/L of DBP, no significant difference in accumulation was found, but treatments with concentration exceeding 10, 30, 50 and 100mg/L all resulted in significant accumulation of DBP. Six protein spots extracted from leaf tissue of DBP-treated Chinese cabbage displaying a differential expression are shown in 2-DE maps. According to proteome level studies, three protein spots were found to increase and were identified, respectively, as acyl-[acyl-carrier-protein] desaturase (acyl-ACP desaturase), root phototropism protein 3 (RPT3) and ferredoxin-nitrite reductase (Fd-NiR). The other three protein spots were found to decrease and were identified respectively as dihydroflavonol-4-reductase (DFR), aminoacyl-tRNA synthetase (aaRS) and ATP synthase subunit beta. The key finding is that the other closely related plant, Bok choy (Brassica rapa subsp. chinensis), the subspecies of Chinese cabbage, respond differently to the same chemicals.

  1. Insecticide susceptibility of three species of cutworm (Lepidoptera: Noctuidae) pests of grapes.

    PubMed

    Smirle, Michael J; Zurowski, Cheryl L; Lowery, D Thomas; Mostafa, Ayman M

    2013-10-01

    Climbing cutworms in the genus Abagrotis are economically important pests of grapes in the Okanagan Valley of British Columbia (BC). Grapes are recently introduced into many areas of the region, and the association between crop and pest is new and still evolving. This has led to limited information being available on pest management strategies, including the evaluation of chemical controls compatible with local production practices. Few insecticides are currently registered in Canada for cutworm control on grapes, and our study was initiated to provide information on the efficacy of potential control materials. We were also interested in the relative susceptibilities of the three most common cutworm species attacking grape buds in BC--Abagrotis orbis (Grote), Abagrotis reedi Buckett, and Abagrotis nefascia (Smith). Dose-response bioassays with nine insecticides were conducted on neonate larvae using Bok Choy leaf disks, and on fourth-instar larvae using diet incorporation. There were considerable differences in the toxicity of insecticides within species for neonates and fourth instars. For some materials, the relative toxicity to neonates and fourth instars were not correlated. Response to insecticides among the three species showed variation as well, and correct identification of the species complex present in individual locations is important in choosing the best available control material.

  2. A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence

    PubMed Central

    Pfeifer, Dietmar; Arnold, Sebastian J.

    2015-01-01

    Trophoblast stem cells (TSCs) represent the multipotent progenitors that give rise to the different cells of the embryonic portion of the placenta. Here, we analysed the expression of key TSC transcription factors Cdx2, Eomes, and Elf5 in the early developing placenta of mouse embryos and in cultured TSCs and reveal surprising heterogeneity in protein levels. We analysed persistence of TSCs in the early placenta and find that TSCs remain in the chorionic hinge until E9.5 and are lost shortly afterwards. To define the transcriptional signature of bona fide TSCs, we used inducible gain- and loss-of-function alleles of Eomes or Cdx2, and EomesGFP, to manipulate and monitor the core maintenance factors of TSCs, followed by genome-wide expression profiling. Combinatorial analysis of resulting expression profiles allowed for defining novel TSC marker genes that might functionally contribute to the maintenance of the TSC state. Analyses by qRT-PCR and in situ hybridisation validated novel TSC- and chorion-specific marker genes, such as Bok/Mtd, Cldn26, Duox2, Duoxa2, Nr0b1, and Sox21. Thus, these expression data provide a valuable resource for the transcriptional signature of bona fide and early differentiating TSCs and may contribute to an increased understanding of the transcriptional circuitries that maintain and/or establish stemness of TSCs. PMID:26783396

  3. Preliminary Results from a Search for a Nebula in the Vicinity of Sirius

    NASA Astrophysics Data System (ADS)

    Mutz, Steven B.; Wyckoff, Susan

    1992-12-01

    Ptolemy, Seneca, and several Babylonian and mediaeval texts have described Sirius (now A1V for the visible component) as a red star (Gry and Bonnet-Bidaud 1990, Schlosser and Bergman 1985). If true, then the present color of Sirius would be very difficult to explain in terms of current theories of stellar evolution. A possible explanation is that Sirius was eclipsed by a small, dark nebula such as a Bok globule (see Gry and Bonnet-Bidaud 1990). To search for such an object J, H, K, and CO (near 2.4 mu ) imaging of the stellar field near Sirius' apparent postion of 2000 years ago was performed using the University of Arizona's 256x256 IR array on their 61-inch Mt Bigelow telescope. Preliminary (J-H) vs. (H-K) diagrams indicate the presence of color excesses in the area of study (following the methods of Jones et al. 1980, 1984). Examination of the Palomar Sky Survey plates for the region of interest shows several areas where the stellar number density is more than 3 sigma smaller than the average stellar density for that area of the sky. Also, the stellar density for these depleted regions is higher on the red Palomar plate than the number density of the regions on the blue plate, suggesting a redder stellar population in these regions, which may be due to the presence of intervening material.

  4. Spectroscopy of Intermediate Mass Members of the Orion OB1a and b associations

    NASA Astrophysics Data System (ADS)

    Walter, Frederick M.; Sherry, William; Kim, Serena; Brittain, Sean

    2010-08-01

    OB associations are ideal sites for probing the formation of low mass stars. There has been little systematic study of the low mass stars in the largest nearby OB association, Orion OB1, aside from the Orion Nebula and σ Ori clusters. In an attempt to map the mass function and its spatial variation from 40 to below 0.01 M_⊙, we have completed a near-IR (JHK) survey of about 18 square degrees in the Orion OB1a and OB1b associations using the CPAPIR camera on the SMARTS/CTIO 1.5m telescope, supplemented by a VRI survey using the Steward Observatory Bok/90Prime and the KPNO 4m/MOSAIC cameras, as well as deep 4m/NEWFIRM images. The photometry reveals thousands of candidate association members. We request time with HYDRA to obtain spectra of the brighter candidate members (V<19), in order to confirm youth and membership from Li abundances, chromospheric activity, and radial velocities.

  5. Star Formation in Dwarf-Dwarf Mergers: Fueling Hierarchical Assembly

    NASA Astrophysics Data System (ADS)

    Stierwalt, Sabrina; Johnson, K. E.; Kallivayalil, N.; Patton, D. R.; Putman, M. E.; Besla, G.; Geha, M. C.

    2014-01-01

    We present early results from the first systematic study a sample of isolated interacting dwarf pairs and the mechanisms governing their star formation. Low mass dwarf galaxies are ubiquitous in the local universe, yet the efficiency of gas removal and the enhancement of star formation in dwarfs via pre-processing (i.e. dwarf-dwarf interactions occurring before the accretion by a massive host) are currently unconstrained. Studies of Local Group dwarfs credit stochastic internal processes for their complicated star formation histories, but a few intriguing examples suggest interactions among dwarfs may produce enhanced star formation. We combine archival UV imaging from GALEX with deep optical broad- and narrow-band (Halpha) imaging taken with the pre- One Degree Imager (pODI) on the WIYN 3.5-m telescope and with the 2.3-m Bok telescope at Steward Observatory to confirm the presence of stellar bridges and tidal tails and to determine whether dwarf-dwarf interactions alone can trigger significant levels of star formation. We investigate star formation rates and global galaxy colors as a function of dwarf pair separation (i.e. the dwarf merger sequence) and dwarf-dwarf mass ratio. This project is a precursor to an ongoing effort to obtain high spatial resolution HI imaging to assess the importance of sequential triggering caused by dwarf-dwarf interactions and the subsequent affect on the more massive hosts that later accrete the low mass systems.

  6. South Galactic Cap u-band Sky Survey (SCUSS): Project Overview

    NASA Astrophysics Data System (ADS)

    Zhou, Xu; Fan, Xiao-Hui; Fan, Zhou; He, Bo-Liang; Jiang, Lin-Hua; Jiang, Zhao-Ji; Jing, Yi-Peng; Lesser, Michael; Ma, Jun; Nie, Jun-Dan; Shen, Shi-Yin; Wang, Jia-Li; Wu, Zhen-Yu; Zhang, Tian-Meng; Zhou, Zhi-Min; Zou, Hu

    2016-04-01

    The South Galactic Cap u-band Sky Survey (SCUSS) was established in 2009 in order to provide a photometric input catalog for target selection of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) project. SCUSS is an international cooperative project between National Astronomical Observatories, Chinese Academy of Sciences, and Steward Observatory at the University of Arizona, using the 90 inch (2.3m) Bok telescope on Kitt Peak. The telescope is equipped with a prime focus camera that is composed of a mosaic of four 4096 × 4096 CCDs and has a field of view of about 1 deg2. From 2009 to 2013, SCUSS performed a sky survey of an approximately 5000 deg2 field of the South Galactic Cap in u band, including the Galactic anticenter area and the SDSS-IV extended imaging area. The limiting magnitude of SCUSS is deeper than 23 mag (at a signal-to-noise ratio of 5). In this paper, we briefly describe the goals of this project, method of observations and data reduction, and we also introduce current and potential scientific activities related to the SCUSS project.

  7. Growth inhibition in Chinese cabbage (Brassica rapa var. chinensis) growth exposed to di-n-butyl phthalate.

    PubMed

    Liao, Chien-Sen; Yen, Jui-Hung; Wang, Yei-Shung

    2009-04-30

    The toxicity and effects of di-n-butyl phthalate (DBP), an endocrine disruptor, on the growth of Chinese cabbage (Brassica rapa var. chinensis) were studied. Etiolation occurred on leaves of Chinese cabbage plant treated with 50mg/L of DBP for 42 d. DBP even below 1mg/L had a significant effect on the concentration of chlorophyll in Chinese cabbage and the biomass showed a severe decrease under treatment with more than 30 mg/L of DBP. At a concentration below 1mg/L of DBP, no significant difference in accumulation was found, but treatments with concentration exceeding 10, 30, 50 and 100mg/L all resulted in significant accumulation of DBP. Six protein spots extracted from leaf tissue of DBP-treated Chinese cabbage displaying a differential expression are shown in 2-DE maps. According to proteome level studies, three protein spots were found to increase and were identified, respectively, as acyl-[acyl-carrier-protein] desaturase (acyl-ACP desaturase), root phototropism protein 3 (RPT3) and ferredoxin-nitrite reductase (Fd-NiR). The other three protein spots were found to decrease and were identified respectively as dihydroflavonol-4-reductase (DFR), aminoacyl-tRNA synthetase (aaRS) and ATP synthase subunit beta. The key finding is that the other closely related plant, Bok choy (Brassica rapa subsp. chinensis), the subspecies of Chinese cabbage, respond differently to the same chemicals. PMID:18678443

  8. Insecticide susceptibility of three species of cutworm (Lepidoptera: Noctuidae) pests of grapes.

    PubMed

    Smirle, Michael J; Zurowski, Cheryl L; Lowery, D Thomas; Mostafa, Ayman M

    2013-10-01

    Climbing cutworms in the genus Abagrotis are economically important pests of grapes in the Okanagan Valley of British Columbia (BC). Grapes are recently introduced into many areas of the region, and the association between crop and pest is new and still evolving. This has led to limited information being available on pest management strategies, including the evaluation of chemical controls compatible with local production practices. Few insecticides are currently registered in Canada for cutworm control on grapes, and our study was initiated to provide information on the efficacy of potential control materials. We were also interested in the relative susceptibilities of the three most common cutworm species attacking grape buds in BC--Abagrotis orbis (Grote), Abagrotis reedi Buckett, and Abagrotis nefascia (Smith). Dose-response bioassays with nine insecticides were conducted on neonate larvae using Bok Choy leaf disks, and on fourth-instar larvae using diet incorporation. There were considerable differences in the toxicity of insecticides within species for neonates and fourth instars. For some materials, the relative toxicity to neonates and fourth instars were not correlated. Response to insecticides among the three species showed variation as well, and correct identification of the species complex present in individual locations is important in choosing the best available control material. PMID:24224256

  9. The Chemistry and Dynamics of the Molecular Outflow in BHR71

    NASA Astrophysics Data System (ADS)

    Bovill, M. S.; Bourke, T. L.; Bergin, E. A.

    2002-12-01

    We present observations of BHR71, in rotational transitions of 12CO, 13CO and C18O and selected additional molecules. BHR71 is an isolated Bok Globule 200 pc from the Sun with an embedded protostellar system, that also contains a highly collimated outflow with unusually active chemistry. Our observations are used to probe the physical and chemical structure of this outflow. We derive the excitation temperature and opacity for several positions in the outflow using the multi-transitional CO data. With this information we estimate the mass to be 1.7 Msun and the excitation temperature to be 15 K in the outflow, slightly elevated above the temperature in the ambient gas (10 K). There is evidence for even higher temperatures towards a position in the blue lobe that is coincident with knots of H2 emission. CO column densities calculated with these temperatures are used to analyze the chemical abundances in the outflow relative to the ambient gas. SiO, CS, HCN, and H2CO all show increased abundances relative to the ambient and molecular ions (HCO+, DCO+, and N+H+) show depletion. These abundances agree qualitatively with those estimated for L1157, the only other outflow that has been extensively studied with regards to the chemistry. However, we find significant disagreements in the magnitude of the abundance changes. BHR71 abundances show agreement with chemical theory. This work was supported in part by NSF grant AST-9731923 to the SAO Summer Intern program.

  10. A deep proper motion catalog within the Sloan digital sky survey footprint

    SciTech Connect

    Munn, Jeffrey A.; Harris, Hugh C.; Tilleman, Trudy M.; Hippel, Ted von; Kilic, Mukremin; Liebert, James W.; Williams, Kurtis A.; DeGenarro, Steven; Jeffery, Elizabeth E-mail: hch@nofs.navy.mil E-mail: ted.vonhippel@erau.edu E-mail: jamesliebert@gmail.com E-mail: studiofortytwo@yahoo.com

    2014-12-01

    A new proper motion catalog is presented, combining the Sloan Digital Sky Survey (SDSS) with second epoch observations in the r band within a portion of the SDSS imaging footprint. The new observations were obtained with the 90prime camera on the Steward Observatory Bok 90 inch telescope, and the Array Camera on the U.S. Naval Observatory, Flagstaff Station, 1.3 m telescope. The catalog covers 1098 square degrees to r = 22.0, an additional 1521 square degrees to r = 20.9, plus a further 488 square degrees of lesser quality data. Statistical errors in the proper motions range from 5 mas year{sup −1} at the bright end to 15 mas year{sup −1} at the faint end, for a typical epoch difference of six years. Systematic errors are estimated to be roughly 1 mas year{sup −1} for the Array Camera data, and as much as 2–4 mas year{sup −1} for the 90prime data (though typically less). The catalog also includes a second epoch of r band photometry.

  11. Expression and Critical Role of Interleukin Enhancer Binding Factor 2 in Hepatocellular Carcinoma.

    PubMed

    Cheng, Shaobing; Jiang, Xu; Ding, Chaofeng; Du, Chengli; Owusu-Ansah, Kwabena Gyabaah; Weng, Xiaoyu; Hu, Wendi; Peng, Chuanhui; Lv, Zhen; Tong, Rongliang; Xiao, Heng; Xie, Haiyang; Zhou, Lin; Wu, Jian; Zheng, Shusen

    2016-01-01

    Interleukin enhancer binding factor 2 (ILF2), a transcription factor, regulates cell growth by inhibiting the stabilization of mRNA. Currently, its role has gained recognition as a factor in the tumorigenic process. However, until now, little has been known about the detailed role ILF2 plays in hepatocellular carcinoma (HCC). In this study, we investigated the expression levels of ILF2 in HCC tissue with Western blot and immunohistochemical assays. To examine the effect of ILF2 on liver cancer cell growth and apoptosis, small interfering RNAs (siRNAs) targeting ILF2 were recombined to create lentiviral overexpression vectors. Our results showed higher expression levels of ILF2 mRNA and ILF2 protein in HCC tissue compared with matched peritumoral tissue. Expression of ILF2 may regulate cell growth and apoptosis in liver cancer cells via regulation of B-cell lymphoma 2 (Bcl-2), Bcl-2 related ovarian killer (Bok), Bcl-2-associated X protein (BAX), and cellular inhibitor of apoptosis 1 (cIAP1). Moreover, we inoculated nude mice with liver cancer cells to investigate the effect of ILF2 on tumorigenesis in vivo. As expected, a rapid growth was observed in cancer cells inoculated with a lentiviral vector coding Flag-ILF2 (Lenti-ILF2) compared with the control cells. Hence, these results promote a better understanding of ILF2's potential role as a therapeutic target in HCC. PMID:27556459

  12. VISITORS FROM THE HALO: 11 Gyr OLD WHITE DWARFS IN THE SOLAR NEIGHBORHOOD

    SciTech Connect

    Kilic, Mukremin; Brown, Warren R.; McLeod, B.; Munn, Jeffrey A.; Harris, Hugh C.; Williams, Kurtis A.; DeGennaro, Steven; Kowalski, P. M.; Von Hippel, Ted; Jeffery, Elizabeth J.

    2010-05-20

    We report the discovery of three nearby old halo white dwarf (WD) candidates in the Sloan Digital Sky Survey (SDSS), including two stars in a common proper motion binary system. These candidates are selected from our 2800deg{sup 2} proper motion survey on the Bok and U.S. Naval Observatory Flagstaff Station 1.3 m telescopes, and they display proper motions of 0.''4-0.''5 yr{sup -1}. Follow-up MMT spectroscopy and near-infrared photometry demonstrate that all three objects are hydrogen-dominated atmosphere WDs with T {sub eff} {approx} 3700-4100 K. For average mass WDs, these temperature estimates correspond to cooling ages of 9-10 Gyr, distances of 70-80 pc, and tangential velocities of 140-200 km s{sup -1}. Based on the UVW space velocities, we conclude that they most likely belong to the halo. Furthermore, the combined main-sequence and WD cooling ages are 10-11 Gyr. Along with SDSS J1102+4113, they are the oldest field WDs currently known. These three stars represent only a small fraction of the halo WD candidates in our proper motion survey, and they demonstrate that deep imaging surveys like the Pan-STARRS and Large Synoptic Survey Telescope should find many old thick disk and halo WDs that can be used to constrain the age of the Galactic thick disk and halo.

  13. Near-IR Spectral Variability Of Young Stars: A Multi-year Survey

    NASA Astrophysics Data System (ADS)

    Hawkins, Clint; Eisner, J.; Rudolph, A. L.

    2012-01-01

    T-Tauri type stars exhibit variability across the electromagnetic spectrum, including in the visible and the infrared regions. While spectroscopic variability in the optical range has been previously investigated, variability in the near-IR has not been explored as thoroughly. We have been tracking the spectral variability of about 40 young stars in the near-IR during the past year. Using the 90-inch Bok telescope on Kitt Peak, we observed our sample with FSPEC during four five-night runs, two in 2010 separated by one month and two in 2011, also separated by one month. Here we present spectra for each of these epochs that show emission from the Brackett Gamma (BrG) transition of hydrogen. Changes in the BrG line profile from epoch to epoch are used to constrain the properties of accretion onto our young star targets as a function of time. We acknowledge the NSF for funding under Award No. AST-0847170, a PAARE Grant for the Calfornia-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE).

  14. The effectiveness of spent coffee grounds and its biochar on the amelioration of heavy metals-contaminated water and soil using chemical and biological assessments.

    PubMed

    Kim, Min-Suk; Min, Hyun-Gi; Koo, Namin; Park, Jeongsik; Lee, Sang-Hwan; Bak, Gwan-In; Kim, Jeong-Gyu

    2014-12-15

    Spent coffee grounds (SCG) and charred spent coffee grounds (SCG-char) have been widely used to adsorb or to amend heavy metals that contaminate water or soil and their success is usually assessed by chemical analysis. In this work, the effects of SCG and SCG-char on metal-contaminated water and soil were evaluated using chemical and biological assessments; a phytotoxicity test using bok choy (Brassica campestris L. ssp. chinensis Jusl.) was conducted for the biological assessment. When SCG and SCG-char were applied to acid mine drainage, the heavy metal concentrations were decreased and the pH was increased. However, for SCG, the phytotoxicity increased because a massive amount of dissolved organic carbon was released from SCG. In contrast, SCG-char did not exhibit this phenomenon because any easily released organic matter was removed during pyrolysis. While the bioavailable heavy metal content decreased in soils treated with SCG or SCG-char, the phytotoxicity only rose after SCG treatment. According to our statistical methodology, bioavailable Pb, Cu and As, as well as the electrical conductivity representing an increase in organic content, affected the phytotoxicity of soil. Therefore, applying SCG during environment remediation requires careful biological assessments and evaluations of the efficiency of this remediation technology. PMID:25242543

  15. Kepler Observations of Three Pre-launch Exoplanet Candidates: Discovery of Two Eclipsing Binaries and a New Exoplanet

    NASA Astrophysics Data System (ADS)

    Howell, Steve B.; Rowe, Jason F.; Sherry, William; von Braun, Kaspar; Ciardi, David R.; Bryson, Stephen T.; Feldmeier, John J.; Horch, Elliott; van Belle, Gerard T.

    2010-12-01

    Three transiting exoplanet candidate stars were discovered in a ground-based photometric survey prior to the launch of NASA's Kepler mission. Kepler observations of them were obtained during Quarter 1 of the Kepler mission. All three stars are faint by radial velocity follow-up standards, so we have examined these candidates with regard to eliminating false positives and providing high confidence exoplanet selection. We present a first attempt to exclude false positives for this set of faint stars without high-resolution radial velocity analysis. This method of exoplanet confirmation will form a large part of the Kepler mission follow-up for Jupiter-sized exoplanet candidates orbiting faint stars. Using the Kepler light curves and pixel data, as well as medium-resolution reconnaissance spectroscopy and speckle imaging, we find that two of our candidates are binary stars. One consists of a late-F star with an early M companion, while the other is a K0 star plus a late M-dwarf/brown dwarf in a 19 day elliptical orbit. The third candidate (BOKS-1) is an r = 15 G8V star hosting a newly discovered exoplanet with a radius of 1.12 R Jupiter in a 3.9 day orbit.

  16. Geomorphological context of the basins of Northwestern Peninsular Malaysia

    NASA Astrophysics Data System (ADS)

    Sautter, Benjamin; Pubellier, Manuel; Menier, David

    2014-05-01

    Geomorphological context of the basins of Northwestern Peninsular Malaysia Benjamin Sautter, Manuel Pubellier, David Menier Department of Petroleum Geosciences, Universiti Teknologi PETRONAS CNRS-UMR 8538, Ecole Normale Supérieure, 24, Rue Lhomond, 75231, Paris Cedex 05, France Petroleum basins of Western Malaysia are poorly known and their formation is controlled by the Tertiary stress variations applied on Mesozoic basement structures. Among these are the Paleozoic-Mesozoic Bentong Raub, Inthanon, and Nan suture zones. By the end of Mesozoic times, the arrival of Indian plate was accompanied by strike slip deformation, accommodated by several Major Faults (Sagaing, Three Pagodas, Mae Ping, Red River, Ranong and Klong Marui Faults). Due to changes in the boundary forces, these areas of weakness (faults) were reactivated during the Tertiary, leading to the opening of basins in most of Sundaland. Within this framework, while most of the Sundaland records stretching of the crust and opening of basins (SCS, Malay, Penyu, Natuna, Mergui) during the Cenozoics, Peninsular Malaysia and the Strait of Malacca are considered to be in tectonic quiescence by most of the authors. We present the geomorphology of the Northwestern Malaysia Peninsula with emphasis on the deformations onshore from the Bentong Raub Suture Zone to the Bok Bak Fault, via the Kinta Valley, and offshore from the Port Klang Graben to the North Penang Graben. By analyzing Digital Elevation Model from ASTER and SRTM data, two main directions of fractures in the granitic plutons are highlighted: NW-SE to W-E sigmoidal faults and N-S to NE-SW linear fractures which seem to cross-cut the others. In the field in the area of the Kinta Valley (Western Belt, NW Peninsular Malaysia), granitic bodies show intense fracturation reflecting several stages of deformation. The granites are generally syntectonic and do not cut fully across the Late Paleozoic platform limestone. Two sets of fractures (NW-SE and NE

  17. Optical Spectroscopy of the Classical Novae V339 Del (2013) and V5668 Sgr (2015 No. 2)

    NASA Astrophysics Data System (ADS)

    Wagner, R. Mark; Woodward, Charles E.; Starrfield, Sumner; Ilyin, Ilya; Strassmeier, Klaus G.; Page, Kim; Osborne, Julian P.; Beardmore, Andrew P.

    2016-01-01

    We report the results of optical spectroscopy of the gamma-ray classical novae V339 Del (2013) and V5668 Sgr (PNV J18365700-2855420/Nova Sgr 2015 No. 2) supplemented by UV and X-ray observations obtained with Swift. Our spectra were obtained with the Steward Observatory Bok 2.3 m telescope (+B&C), the MDM 2.4 m Hiltner telescope (+OSMOS), the 6.5 m MMT (+BlueChannel), and the 2 x 8.4 m Large Binocular Telescope (+MODS1 and PEPSI) between 2013 August and 2015 September. The PEPSI spectra cover all or part of the 384-907 nm spectral region at a resolution of up to 270,000 (1 km/s). This is the highest resolution available on any 8-10 m class telescope. V339 Del was discovered on 2015 August 14.58 by Itagaki at V about 6.8. This nova reached a peak magnitude of about 4.3 making it one of the brightest novae of this century. Because of its exceptional brightness it has been observed at a variety of wavelengths and by a host of observatories both on the ground and in space. V5668 Sgr was discovered on 2015 March 15.634 by Seach at a magnitude of 6.0. It subsequently reached a maximum brightness of about 4.0 in late March. High resolution PEPSI spectra obtained in early April show dramatic variations in the multi-component P Cygni-type line profiles. V5668 Sgr was observed to form dust in June thereafter fading to about 13th magnitude. Our recent observations show that it has now evolved into the nebular phase. SS acknowledges partial support from NSF and NASA grants to ASU. CEW acknowledges support from NASA.

  18. High-performance liquid chromatography-mass spectrometry analysis of plant metabolites in brassicaceae.

    PubMed

    De Vos, Ric C H; Schipper, Bert; Hall, Robert D

    2012-01-01

    The Brassicaceae family comprises a variety of plant species that are of high economic importance as -vegetables or industrial crops. This includes crops such as Brassica rapa (turnip, Bok Choi), B. oleracea (cabbages, broccoli, cauliflower, etc.), and B. napus (oil seed rape), and also includes the famous genetic model of plant research, Arabidopsis thaliana (thale cress). Brassicaceae plants contain a large variety of interesting secondary metabolites, including glucosinolates, hydroxycinnamic acids, and flavonoids. These metabolites are also of particular importance due to their proposed positive effects on human health. Next to these well-known groups of phytochemicals, many more metabolites are of course also present in crude extracts prepared from Brassica and Arabidopsis plant material.High-pressure liquid chromatography coupled to mass spectrometry (HPLC-MS), especially if combined with a high mass resolution instrument such as a QTOF MS, is a powerful approach to separate, detect, and annotate metabolites present in crude aqueous-alcohol plant extracts. Using an essentially unbiased procedure that takes into account all metabolite mass signals from the raw data files, detailed information on the relative abundance of hundreds of both known and, as yet, unknown semipolar metabolites can be obtained. These comprehensive metabolomics data can then be used to, for instance, identify genetic markers regulating metabolic composition, determine effects of (a)biotic stress or specific growth conditions, or establish metabolite changes occurring upon food processing or storage.This chapter describes in detail a procedure for preparing crude extracts and performing comprehensive HPLC-QTOF MS-based profiling of semi-polar metabolites in Brassicaceae plant material. Compounds present in the extract can be (partially or completely) annotated based on their accurate mass, their MS/MS fragments and on other specific chemical characteristics such as retention time and UV

  19. Political Activity at Harvard College Observatory in the Shapley ERA (1921-1952): Controversy and Consequences.

    NASA Astrophysics Data System (ADS)

    Welther, Barbara L.

    1993-12-01

    Soon after Harlow Shapley became director of HCO in 1921, he established himself as a scientist who would speak out and take action on national and international issues. Recognizing the importance of international cooperation in astronomy, he frequently traveled abroad and in turn invited foreign scientists to visit and work at HCO. By the mid-1930s, Shapley was actively rescuing refugee scientists in war-torn Europe and placing them in American universities. Both Harvard and the FBI took note of his activities. Shapley feared intervention of any kind from either academia or the government. Desperate for funding, however, he finally went to Washington and lobbied Congress to set up the NSF. Through 1945, when Truman succeeded Roosevelt, Shapley pursued his political activities freely. That year he travelled to Moscow to represent Harvard at the 220th anniversary celebration of the Academy of Sciences. In Moscow he advocated international cooperation between Soviet and American scientists. Consequently, Shapley was subpoenaed for interrogation in 1946 by John Rankin, who served during the Truman administration as a one-man committee to investigate un-American activities. The ordeal infuriated Shapley. Headlines about it infuriated some Harvard alumni who urged the university to fire him. Although Shapley was nearing retirement, President Conant stood by his right to keep his job. By 1950, when Senator Joseph McCarthy was compiling a list of Communist sympathizers in the State Department, the FBI had a dossier on Shapley. McCarthy subpoenaed Shapley, but could not intimidate him. The Senator continued the witch hunt with Shapley's associates. First he harassed Martha Betz Shapley, then Donald Menzel. Both cleared themselves. Other associates, such as Bart Bok, were spared. Ultimately, the interrogation worked in Menzel's favor. It disassociated him from Shapley's ideology and political activities. When the Harvard Corporation sought the next director of HCO, Menzel

  20. DISCOVERING THE MISSING 2.2 < z < 3 QUASARS BY COMBINING OPTICAL VARIABILITY AND OPTICAL/NEAR-INFRARED COLORS

    SciTech Connect

    Wu Xuebing; Wang Ran; Bian Fuyan; Jiang Linhua; Fan Xiaohui; Schmidt, Kasper B.

    2011-09-15

    The identification of quasars in the redshift range 2.2 < z < 3 is known to be very inefficient because the optical colors of such quasars are indistinguishable from those of stars. Recent studies have proposed using optical variability or near-infrared (near-IR) colors to improve the identification of the missing quasars in this redshift range. Here we present a case study combining both methods. We select a sample of 70 quasar candidates from variables in Sloan Digital Sky Survey (SDSS) Stripe 82, which are non-ultraviolet excess sources and have UKIDSS near-IR public data. They are clearly separated into two parts on the Y - K/g - z color-color diagram, and 59 of them meet or lie close to a newly proposed Y - K/g - z selection criterion for z < 4 quasars. Of these 59 sources, 44 were previously identified as quasars in SDSS DR7, and 35 of them are quasars at 2.2 < z < 3. We present spectroscopic observations of 14 of 15 remaining quasar candidates using the Bok 2.3 m telescope and the MMT 6.5 m telescope, and successfully identify all of them as new quasars at z = 2.36-2.88. We also apply this method to a sample of 643 variable quasar candidates with SDSS-UKIDSS nine-band photometric data selected from 1875 new quasar candidates in SDSS Stripe 82 given by Butler and Bloom based on the time-series selections, and find that 188 of them are probably new quasars with photometric redshifts at 2.2 < z < 3. Our results indicate that the combination of optical variability and optical/near-IR colors is probably the most efficient way to find 2.2 < z < 3 quasars and is very helpful for constructing a complete quasar sample. We discuss its implications for ongoing and upcoming large optical and near-IR sky surveys.

  1. Morphological variation, advertisement call, and tadpoles of Bokermannohyla nanuzae (Bokermann, 1973), and taxonomic status of B. feioi (Napoli & Caramaschi, 2004) (Anura, Hylidae, Cophomantini).

    PubMed

    Walker, Marina; Lourenço, Ana Carolina Calijorne; Pimenta, Bruno V S; Nascimento, Luciana Barreto

    2015-01-01

    Bokermannohyla nanuzae (Bokermann & Sazima 1973) and B. feioi (Napoli & Caramaschi 2004) belong to the B. cir-cumdata species group. The type locality of the former is Serra do Cipó, Espinhaço mountain range, and of the latter is Parque Estadual do Ibitipoca, Mantiqueira mountain range, both in Minas Gerais State, Brazil. Differences on dorsal draw-ing pattern of adults, oral disc morphology of tadpoles, and temporal properties of calls were proposed to distinguish these two species. However, several specimens found between the two type localities remain unidentified because diagnostic characters and states occur in all of these populations. Thus, in order to assess these characters variations, we performed an analysis of the morphology and morphometry of adults, vocalization, and morphology of tadpoles. Specimens were divided into three operational taxonomic units (OTUs): B. nanuzae (Serra do Cipó and northwards, Espinhaço mountain range), B. cf. nanuzae (Quadrilátero Ferrífero, Espinhaço mountain range, south of Serra do Cipó), and B. feioi (Serra do Ibitipoca, Mantiqueira mountain range). Drawing patterns of the dorsum and limbs show clinal variation and the three units are morphometrically very similar. Temporal and spectral properties of calls overlap in these three units. The diagnostic differences originally proposed for tadpoles are intrapopulational variations and occur in specimens from all of the locations analyzed. We found that these three units are morphologically indistinguishable. Therefore, we designate Bok-ermannohyla feioi (Napoli & Caramaschi 2004) as a junior synonym of Bokermannohyla nanuzae (Bokermann & Sazima 1973), extending its geographical distribution to the Mantiqueira mountain range. PMID:25947466

  2. Coagulation of grains in static and collapsing protostellar clouds

    NASA Technical Reports Server (NTRS)

    Weidenschilling, S. J.; Ruzmaikina, T. V.

    1994-01-01

    We simulate collisional evolution of grains in dense turbulent molecular cloud cores (or Bok globules) in static equilibrium and free-fall collapse, assuming spherical symmetry. Relative velocities are due to thermal motions, differential settling, and turbulence, with the latter dominant for sonic turbulence with an assumed Kolmogorov spectrum. Realistic criteria are used to determine outcomes of collisions (coagulation vs. destruction) as functions of particle size and velocity. Results are presented for a variety of cloud parameters (radial density profile, turbulent velocity) and particle properties (density, impact strength). Results are sensitive to the assumed mechanical properties (density and impact strength) of grain aggregates. Particle growth is enhanced if aggregates have low density or fractal structures. On a timescale of a few Myr, an initial population of 0.1 micrometers grains may produce dense compact particles approximately 1 micrometer in size, or fluffy aggregates approximately 100 micrometers. For impact strengths less than or equal to 10(exp 6) ergs/g, a steady state is reached between coagulation of small grains and collisional disruption of larger aggregates. Formation of macroscopic aggregates requires high mechanical strengths and low aggregate densities. We assume sonic turbulence during collapse, with varied eddy size scales determining the dissipation rate or turbulence strength. The degree of collisional evolution during collapse is sensitive to the assumed small-scale structure (inner sc ale) of the turbulence. Weak turbulence results in few collisions and preserves the precollapse particle size distribution with little change. Strong turbulence tends to produce net destruction, rather than particle growth, during infall, unless inpact strengths are greater than 10(exp 6)ergs/g.

  3. VizieR Online Data Catalog: SDSS-RM project: technical overview (Shen+, 2015)

    NASA Astrophysics Data System (ADS)

    Shen, Y.; Brandt, W. N.; Dawson, K. S.; Hall, P. B.; McGreer, I. D.; Anderson, S. F.; Chen, Y.; Denney, K. D.; Eftekharzadeh, S.; Fan, X.; Gao, Y.; Green, P. J.; Greene, J. E.; Ho, L. C.; Horne, K.; Jiang, L.; Kelly, B. C.; Kinemuchi, K.; Kochanek, C. S.; Paris, I.; Peters, C. M.; Peterson, B. M.; Petitjean, P.; Ponder, K.; Richards, G. T.; Schneider, D. P.; Seth, A.; Smith, R. N.; Strauss, M. A.; Tao, C.; Trump, J. R.; Wood-Vasey, W. M.; Zu, Y.; Eisenstein, D. J.; Pan, K.; Bizyaev, D.; Malanushenko, V.; Malanushenko, E.; Oravetz, D.

    2015-02-01

    Our reverberation mapping (RM) field is the Pan-STARRS 1 (PS1) Medium Deep Field (MDF) MD07 (RAJ2000=213.704, DEJ2000=+53.083), which is a 7deg2 field within the CFHT-LS W3 field. This field is fully covered in the SDSS-I/II and SDSS-III BOSS footprints. The final RM sample contains 849 quasars, each of which was assigned a fiber on the RM plates. The remaining fibers were allocated to calibration sources, including 70 spectrophotometric standard stars, 80 sky fibers, and 1 LRG target (enforced by the BOSS tiling algorithm, but actually not tiled on any existing object in SDSS imaging). The BOSS spectroscopic observations were acquired during 7 dark/gray runs from 2014 January 1 to 2014 July 3. The separation between epochs in a given run is roughly 3-4 days, but varies from run to run under different weather conditions. Typically five epochs were taken for each run when weather permitted, totaling 32 epochs. The main portion of the RM imaging of our program is obtained with the CFHT/MegaCam and the Steward Observatory Bok 2.3m/90Prime. Given that our RM sample covers a wide redshift range, the photometric monitoring is performed in the SDSS g band and i band to sample the quasar continuum at low and high redshifts, respectively. We also had six nights of KPNO-4m (Mayall)/MOSAIC-1.1 observation to perform multi-band (Ugriz) imaging of the RM field. (4 data files).

  4. Morphological variation, advertisement call, and tadpoles of Bokermannohyla nanuzae (Bokermann, 1973), and taxonomic status of B. feioi (Napoli & Caramaschi, 2004) (Anura, Hylidae, Cophomantini).

    PubMed

    Walker, Marina; Lourenço, Ana Carolina Calijorne; Pimenta, Bruno V S; Nascimento, Luciana Barreto

    2015-03-24

    Bokermannohyla nanuzae (Bokermann & Sazima 1973) and B. feioi (Napoli & Caramaschi 2004) belong to the B. cir-cumdata species group. The type locality of the former is Serra do Cipó, Espinhaço mountain range, and of the latter is Parque Estadual do Ibitipoca, Mantiqueira mountain range, both in Minas Gerais State, Brazil. Differences on dorsal draw-ing pattern of adults, oral disc morphology of tadpoles, and temporal properties of calls were proposed to distinguish these two species. However, several specimens found between the two type localities remain unidentified because diagnostic characters and states occur in all of these populations. Thus, in order to assess these characters variations, we performed an analysis of the morphology and morphometry of adults, vocalization, and morphology of tadpoles. Specimens were divided into three operational taxonomic units (OTUs): B. nanuzae (Serra do Cipó and northwards, Espinhaço mountain range), B. cf. nanuzae (Quadrilátero Ferrífero, Espinhaço mountain range, south of Serra do Cipó), and B. feioi (Serra do Ibitipoca, Mantiqueira mountain range). Drawing patterns of the dorsum and limbs show clinal variation and the three units are morphometrically very similar. Temporal and spectral properties of calls overlap in these three units. The diagnostic differences originally proposed for tadpoles are intrapopulational variations and occur in specimens from all of the locations analyzed. We found that these three units are morphologically indistinguishable. Therefore, we designate Bok-ermannohyla feioi (Napoli & Caramaschi 2004) as a junior synonym of Bokermannohyla nanuzae (Bokermann & Sazima 1973), extending its geographical distribution to the Mantiqueira mountain range.

  5. Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation

    PubMed Central

    de Oliveira, G L V; Malmegrim, K C R; Ferreira, A F; Tognon, R; Kashima, S; Couri, C E B; Covas, D T; Voltarelli, J C; de Castro, F A

    2012-01-01

    Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T cell-mediated destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycaemia. Recent studies have described that apoptosis impairment during central and peripheral tolerance is involved in T1D pathogenesis. In this study, the apoptosis-related gene expression in T1D patients was evaluated before and after treatment with high-dose immunosuppression followed by autologous haematopoietic stem cell transplantation (HDI-AHSCT). We also correlated gene expression results with clinical response to HDI-AHSCT. We observed a decreased expression of bad, bax and fasL pro-apoptotic genes and an increased expression of a1, bcl-xL and cIAP-2 anti-apoptotic genes in patients' peripheral blood mononuclear cells (PBMCs) compared to controls. After HDI-AHSCT, we found an up-regulation of fas and fasL and a down-regulation of anti-apoptotic bcl-xL genes expression in post-HDI-AHSCT periods compared to pre-transplantation. Additionally, the levels of bad, bax, bok, fasL, bcl-xL and cIAP-1 genes expression were found similar to controls 2 years after HDI-AHSCT. Furthermore, over-expression of pro-apoptotic noxa at 540 days post-HDI-AHSCT correlated positively with insulin-free patients and conversely with glutamic acid decarboxylase autoantibodies (GAD65) autoantibody levels. Taken together, the results suggest that apoptosis-related genes deregulation in patients' PBMCs might be involved in breakdown of immune tolerance and consequently contribute to T1D pathogenesis. Furthermore, HDI-AHSCT modulated the expression of some apoptotic genes towards the levels similar to controls. Possibly, the expression of these apoptotic molecules could be applied as biomarkers of clinical remission of T1D patients treated with HDI-AHSCT therapy. PMID:22519592

  6. Nitroreductase-mediated gonadal dysgenesis for infertility control of genetically modified zebrafish.

    PubMed

    Hu, Shao-Yang; Lin, Pei-Yu; Liao, Chia-Hsuan; Gong, Hong-Yi; Lin, Gen-Hwa; Kawakami, Koichi; Wu, Jen-Leih

    2010-10-01

    Genetically modified (GM) fish with desirable features such as rapid growth, disease resistance, and cold tolerance, among other traits, have been established in aquaculture. However, commercially available GM fish are restricted because of global concerns over the incomplete assessments of food safety and ecological impact. The ecological impact concerns include gene flow and escape of the GM fish, which may cause extinction of wild natural fish stocks. Infertility control is a core technology for overcoming this obstacle. Although polyploidy technology, GnRH-specific antisense RNA, and RNAi against GnRH gene expression have been used to cause infertility in fish, these approaches are not 100% reliable and are not heritable. In the present study, zebrafish was used as a model to establish an inducible platform of infertility control in GM fish. Nitroreductase, which converts metronidazole substrate into cytotoxin, was fused with EGFP and expressed specifically by oocytes in the Tg(ZP:NTR-EGFP) by a zona pellucida promoter. Through consecutive immersion of metronidazole from 28 to 42 days posthatching, oocyte-specific EGFP expression was eliminated, and atrophy of the gonads was detected by anatomical analysis. These findings reveal that oocyte-specific nitroreductase-mediated catalysis of metronidazole blocks oogenesis and leads to an undeveloped oocyte. Furthermore, oocyte cell death via apoptosis was detected by a TUNEL assay. We found that the gonadal dysgenesis induced by metronidazole resulted in activation of the ovarian killer gene bok, which is a proapoptotic gene member of the Bcl-2 family and led to infertility. These results show that oocyte-specific nitroreductase-mediated catalysis of metronidazole can cause reliable infertility in zebrafish and could potentially be used as a model for other aquaculture fish species.

  7. Nuclear export of proteins and drug resistance in cancer.

    PubMed

    Turner, Joel G; Dawson, Jana; Sullivan, Daniel M

    2012-04-15

    The intracellular location of a protein is crucial to its normal functioning in a cell. Cancer cells utilize the normal processes of nuclear-cytoplasmic transport through the nuclear pore complex of a cell to effectively evade anti-neoplastic mechanisms. CRM1-mediated export is increased in various cancers. Proteins that are exported in cancer include tumor-suppressive proteins such as retinoblastoma, APC, p53, BRAC1, FOXO proteins, INI1/hSNF5, galectin-3, Bok, nucleophosmin, RASSF2, Merlin, p21(CIP), p27(KIP1), N-WASP/FAK, estradiol receptor and Tob, drug targets topoisomerase I and IIα and BCR-ABL, and the molecular chaperone protein Hsp90. Here, we review in detail the current processes and known structures involved in the export of a protein through the nuclear pore complex. We also discuss the export receptor molecule CRM1 and its binding to the leucine-rich nuclear export signal of the cargo protein and the formation of a nuclear export trimer with RanGTP. The therapeutic potential of various CRM1 inhibitors will be addressed, including leptomycin B, ratjadone, KOS-2464, and specific small molecule inhibitors of CRM1, N-azolylacrylate analogs, FOXO export inhibitors, valtrate, acetoxychavicol acetate, CBS9106, and SINE inhibitors. We will also discuss examples of how drug resistance may be reversed by targeting the exported proteins topoisomerase IIα, BCR-ABL, and galectin-3. As effective and less toxic CRM1 export inhibitors become available, they may be used as both single agents and in combination with current chemotherapeutic drugs. We believe that the future development of low-toxicity, small-molecule CRM1 inhibitors may provide a new approach to treating cancer.

  8. The pre-main-sequence star V1184 Tauri (CB 34V) at the end of prolonged eclipse

    NASA Astrophysics Data System (ADS)

    Semkov, E. H.; Peneva, S. P.; Ibryamov, S. I.

    2015-10-01

    Aims: V1184 Tau (CB 34V) lies in the field of the Bok globule CB 34 and was discovered as a large amplitude variable in 1993. According to the first hypothesis of the variability of the star, it is a FU Orionis candidate erupted between 1951 and 1993. During subsequent observations, the star manifests large amplitude variability interpreted as obscuration from circumstellar clouds of dust. We included V1184 Tau (CB 34V) in our target list of highly variable pre-main-sequence stars to determine the reasons for the variations in the brightness of this object. Methods: Data from BVRI photometric observations of the young stellar object V1184 Tau, obtained in the period 2008-2015, are presented in the paper. These data are a continuation of our optical photometric monitoring of the star began in 2000 and continuing to date. The photometric observations of V1184 Tau were performed in two observatories with two medium-sized and two small telescopes. Results: Our results indicate that during periods of maximum light the star shows characteristics typical of T Tauri stars. During the observed deep minimum in brightness, however, V1184 Tau is rather similar to UX Orionis objects. The deep drop in brightness began in 2003 ended in 2015 as the star has returned to maximum light. The light curve during the drop is obviously asymmetric as the decrease in brightness lasts two times longer than the rise. The observed colour reverse on the colour-magnitude diagrams is also confirmation of obscuration from circumstellar clouds of dust as a reason for the large amplitude variability in the brightness. Appendix A is available in electronic form at http://www.aanda.org

  9. Astronomy Camp = IYA x 22: 22 Years of International Astronomy Education

    NASA Astrophysics Data System (ADS)

    Hooper, Eric Jon; McCarthy, D. W.; Camp Staff, Astronomy

    2010-01-01

    Do you remember childhood dreams of being an astronomer, or the ravenous desire for ever larger glass and better equipment as an amateur astronomer? What if your child or the person down the street could live that dream for a weekend or a week? The University of Arizona Astronomy Camp continues to substantiate those dreams after more than two decades in existence. Astronomy Camp is an immersion hands-on field experience in astronomy, ranging from two to eight nights, occurring a few times per year. Participants span an age range from elementary students to octogenarians. The three basic offerings include adult camps, a beginning Camp for teenagers, and an advanced teen Camp. Several variants of the basic Camp model have evolved, including an ongoing decade long series of specialized Camps for Girl Scout leaders from across the country, funded by the NIRCam instrument development program for the James Webb Space Telescope. The advanced teen Camp is a microcosm of the entire research arc: the participants propose projects, spend the week collecting and analyzing data using research grade CCDs, infrared arrays, and radio/sub-millimeter telescopes, and finish with a presentation of the results. This past summer the Camps moved to Kitt Peak National Observatory for the first time, providing access to a vast and diverse collection of research instruments, including the 0.9-meter WIYN and 2.3-meter Bok telescopes, the McMath-Pierce Solar Telescope, and the 12-meter ARO radio telescope. Education research into the Camp's impact indicates that reasons for its appeal to youth include a learner-centered and personal approach with a fun attitude toward learning, authentic scientific inquiry led by mentors who are real scientists, a peer group with common interests in science and engineering, and the emotional appeal of spending time on a dark "sky island" devoted to the exploration of nature.

  10. A Comparative Study of the Mass Distribution of Extreme-Ultraviolet-selected White Dwarfs

    NASA Astrophysics Data System (ADS)

    Napiwotzki, R.; Green, Paul J.; Saffer, Rex A.

    1999-05-01

    We present new determinations of effective temperature, surface gravity, and masses for a sample of 46 hot DA white dwarfs selected from the Extreme Ultraviolet Explorer (EUVE) and ROSAT Wide Field Camera bright source lists in the course of a near-infrared survey for low-mass companions. Our analysis, based on hydrogen non-LTE model atmospheres, provides a map of LTE correction vectors, which allow a thorough comparison with previous LTE studies. We find that previous studies underestimate both the systematic errors and the observational scatter in the determination of white dwarf parameters obtained via fits to model atmospheres. The structure of very hot or low-mass white dwarfs depends sensitively on their history. To compute white dwarf masses, we thus use theoretical mass-radius relations that take into account the complete evolution from the main sequence. We find a peak mass of our white dwarf sample of 0.59 Msolar, in agreement with the results of previous analyses. However, we do not confirm a trend of peak mass with temperature reported in two previous analyses. Analogous to other EUV-selected samples, we note a lack of low-mass white dwarfs and a large fraction of massive white dwarfs. Only one white dwarf is likely to have a helium core. While the lack of helium white dwarfs in our sample can be easily understood from their high cooling rate, and therefore low detection probability in our temperature range, this is not enough to explain the large fraction of massive white dwarfs. This feature very likely results from a decreased relative sample volume for low-mass white dwarfs caused by interstellar absorption in EUV-selected samples. Spectral observations reported here were obtained with the Multiple Mirror Telescope, a joint facility of the University of Arizona and the Smithsonian Institution, and with the Bok telescope at the Steward Observatory of the University of Arizona.

  11. Suppressed Expression of T-Box Transcription Factors is Involved in Senescence in Chronic Obstructive Pulmonary Disease

    SciTech Connect

    Acquaah-Mensah, George; Malhotra, Deepti; Vulimiri, Madhulika; McDermott, Jason E.; Biswal, Shyam

    2012-06-19

    Chronic obstructive pulmonary disease (COPD) is a major global health problem. The etiology of COPD has been associated with apoptosis, oxidative stress, and inflammation. However, understanding of the molecular interactions that modulate COPD pathogenesis remains only partly resolved. We conducted an exploratory study on COPD etiology to identify the key molecular participants. We used information-theoretic algorithms including Context Likelihood of Relatedness (CLR), Algorithm for the Reconstruction of Accurate Cellular Networks (ARACNE), and Inferelator. We captured direct functional associations among genes, given a compendium of gene expression profiles of human lung epithelial cells. A set of genes differentially expressed in COPD, as reported in a previous study were superposed with the resulting transcriptional regulatory networks. After factoring in the properties of the networks, an established COPD susceptibility locus and domain-domain interactions involving protein products of genes in the generated networks, several molecular candidates were predicted to be involved in the etiology of COPD. These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML. Furthermore, T-box (TBX) genes and cyclin-dependent kinase inhibitor 2A (CDKN2A), which are in a direct transcriptional regulatory relationship, emerged as preeminent participants in the etiology of COPD by means of senescence. Contrary to observations in neoplasms, our study reveals that the expression of genes and proteins in the lung samples from patients with COPD indicate an increased tendency towards cellular senescence. The expression of the anti-senescence mediators TBX transcription factors, chromatin modifiers histone deacetylases, and sirtuins was suppressed; while the expression of TBX-regulated cellular senescence markers such as CDKN2A, CDKN1A, and CAV1 was elevated in the peripheral lung tissue samples from patients with COPD. The critical balance between senescence

  12. Life Cycle of Stars

    NASA Technical Reports Server (NTRS)

    1999-01-01

    In this stunning picture of the giant galactic nebula NGC 3603, the crisp resolution of NASA's Hubble Space Telescope captures various stages of the life cycle of stars in one single view. To the upper left of center is the evolved blue supergiant called Sher 25. The star has a unique circumstellar ring of glowing gas that is a galactic twin to the famous ring around the supernova 1987A. The grayish-bluish color of the ring and the bipolar outflows (blobs to the upper right and lower left of the star) indicates the presence of processed (chemically enriched) material. Near the center of the view is a so-called starburst cluster dominated by young, hot Wolf-Rayet stars and early O-type stars. A torrent of ionizing radiation and fast stellar winds from these massive stars has blown a large cavity around the cluster. The most spectacular evidence for the interaction of ionizing radiation with cold molecular-hydrogen cloud material are the giant gaseous pillars to the right of the cluster. These pillars are sculptured by the same physical processes as the famous pillars Hubble photographed in the M16 Eagle Nebula. Dark clouds at the upper right are so-called Bok globules, which are probably in an earlier stage of star formation. To the lower left of the cluster are two compact, tadpole-shaped emission nebulae. Similar structures were found by Hubble in Orion, and have been interpreted as gas and dust evaporation from possibly protoplanetary disks (proplyds). This true-color picture was taken on March 5, 1999 with the Wide Field Planetary Camera 2.

  13. [Effects of aging time on the form transformation and eco-toxicity threshold (ECx) of added Zn in typical China soils].

    PubMed

    Lin, Lei; Chen, Shi-Bao; Liu, Ji-Fang; Ma, Yi-Bing

    2013-07-01

    Six typical China soils with different properties were selected and added with seven concentrations of ZnCl2 to study the effects of different aging time (14, 90, 180, 360, and 540 days) on the form transformation and eco-toxicity threshold (ECx) of added Zn in the soils, with the main affecting factors analyzed. The results indicated that with the increase of aging time, the fraction of 0.01 mol x L(-1) CaCl2-extracted Zn in the soils decreased sharply initially, then slowed down, and reached the dynamic balance after 540 d incubation. The eco-toxicity thresholds (ECx, x = 10, 50) of Zn to bok choy increased significantly with aging time (P < 0.05), which implied the marked decrease of the phyto-toxicity of Zn. The measured aging factors AF10 and AF50 of Zn ranged from 1.077-1.743 and 1.174-1.441, respectively, and increased with aging time. The balanced concentration of Zn in the soils was significantly negatively correlated with soil pH, CEC, and organic carbon (Org-C) content, and soil pH was the most important controlling factor, followed by CEC and Org-C. It took shorter time to reach Zn balance in the soils with higher pH. The prediction model of the ECx of Zn was developed based on the aging factors and the main soil properties, and could be well validated by the measured ECx under field condition. This study would provide theoretical basis for the normalization of the eco-toxicity thresholds of added Zn in different soils and the formulation of the environmental criterion of Zn in China soils.

  14. Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China.

    PubMed

    Fowke, Jay H; Shu, Xiao-Ou; Dai, Qi; Shintani, Ayumi; Conaway, C Clifford; Chung, Fung-Lung; Cai, Qiuyin; Gao, Yu-Tang; Zheng, Wei

    2003-12-01

    Alternative measures of Brassica vegetable consumption (e.g., cabbage) may clarify the association between Brassica and cancer risk. Brassica isothiocyanates (ITCs) are excreted in urine and may provide a sensitive and food-specific dietary biomarker. However, the persistence of ITCs in the body may be brief and dependent on the activity of several Phase II enzymes, raising questions about the relationship between a single ITC measure and habitual dietary patterns. This study investigates the association between urinary ITC excretion and habitual Brassica consumption, estimated by a food frequency questionnaire, among healthy Chinese women enrolled in the Shanghai Breast Cancer Study. Participants (n = 347) completed a validated food frequency questionnaire querying habitual dietary intake during the prior 5 years and provided a fasting first-morning urine specimen. Genetic deletion of glutathione S-transferases (GSTM1/GSTT1), and single nucleotide substitutions in GSTP1 (A313G) and NAD(P)H:quinone oxidoreductase 1 (NQO1: C609T), were identified from blood DNA. Urinary ITC excretion levels were marginally higher with the GSTT1-null or GSTP1-G/G genotypes (P = 0.07, P = 0.05, respectively). Mean habitual Brassica intake was 98.3 g/day, primarily as bok choy, and Brassica intake significantly increased across quartile categories of ITC levels. The association between habitual Brassica intake and urinary ITC levels was stronger among women with GSTT1-null or GSTP1-A/A genotypes, or NQO1 T-allele, and the interaction was statistically significant across GSTP1 genotype. In conclusion, a single urinary ITC measure, in conjunction with markers of Phase II enzyme activity, provides a complementary measure of habitual Brassica intake among Shanghai women.

  15. Plant growth inhibition by cis-cinnamoyl glucosides and cis-cinnamic acid.

    PubMed

    Hiradate, Syuntaro; Morita, Sayaka; Furubayashi, Akihiro; Fujii, Yoshiharu; Harada, Jiro

    2005-03-01

    Spiraea thunbergii Sieb. contains 1-O-cis-cinnamoyl-beta-D-glucopyranose (CG) and 6-O-(4'-hydroxy-2'-methylene-butyroyl)-1-O-cis-cinnamoyl-beta-D-glucopyranose (BCG) as major plant growth inhibiting constituents. In the present study, we determined the inhibitory activity of CG and BCG on root elongation of germinated seedlings of lettuce (Lactuca sativa), pigweed (Amaranthus retroflexus), red clover (Trifolium pratense), timothy (Phleum pratense), and bok choy (Brassica rapa var chinensis) in comparison with that of two well-known growth inhibitors, 2,4-dichlorophenoxyacetic acid (2,4-D) and (+)-2-cis-4-trans-abscisic acid (cis-ABA), as well as two related chemicals of CG and BCG, cis-cinnamic acid (cis-CA) and trans-cinnamic acid (trans-CA). The EC50 values for CG and BCG on lettuce were roughly one-half to one-quarter of the value for cis-ABA. cis-Cinnamic acid, which is a component of CG and BCG, possessed almost the same inhibitory activity of CG and BCG, suggesting that the essential chemical structure responsible for the inhibitory activity of CG and BCG is cis-CA. The cis-stereochemistry of the methylene moiety is apparently needed for high inhibitory activity, as trans-CA had an EC50 value roughly 100 times that of CG, BCG, and cis-CA. Growth inhibition by CG, BCG, and cis-CA was influenced by the nature of the soil in the growing medium: alluvial soil preserved the bioactivity, whereas volcanic ash and calcareous soils inhibited bioactivity. These findings indicate a potential role of cis-CA and its glucosides as allelochemicals for use as plant growth regulators in agricultural fields.

  16. Perspectives on the Happiness of Community-Dwelling Elderly in Korea

    PubMed Central

    Jeon, Sang Won; Lee, Jongha; Lim, JaeHyoung; Jeong, Hyun-Ghang; Park, Moon Ho; Ko, Young-Hoon; Pae, Chi-Un; Kim, Seung Hyun; Joe, Sook-Haeng; Steffens, David C.

    2016-01-01

    Objective A community survey was performed to investigate the factors and perspectives associated with happiness among the elderly in Korea (≥60 years). Methods Eight hundred volunteers selected from participants in the Ansan Geriatric study (AGE study) were enrolled, and 706 completed the survey. The Happiness Questionnaire (HQ), which asks four questions about happiness, was administered. To explore the relationship between happiness and depression, the Geriatric Depression Scale (GDS) and the Beck Depression Inventory (BDI) also were administered. Results The participants' average level of happiness, determined using a 100-mm visual analogue scale (VAS) of the HQ, was 64.7±26.0. The happiest situations for most people were "getting together with family" (23.8%) and "living in peace with family members (well-being)" (13.2%). Frequent reasons for not being happy were "worsened health condition" (28.7% of the not-happy group), "economic problems of their own" (16.5%), and "economic problems of their children" (14.8%). The participants' choices regarding the essential conditions for happiness were "good health" (65.3%) and "being with family" (20.5%). The BDI and GDS scores were negatively related to the happiness score. A preliminary scale [Happy (Haeng-Bok, 幸福) aging scale] based on the HQ for measuring the happiness level of the Korean elderly was suggested for follow-up studies. Conclusion The most important factors determining the happiness of the community-dwelling elderly in Korea were good family relationships, economic stability, and good health. A higher depression score negatively impacted happiness among Korean elders. Further studies on the factors in their happiness are required. PMID:26766946

  17. Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles.

    PubMed

    Craig, Zelieann R; Hannon, Patrick R; Wang, Wei; Ziv-Gal, Ayelet; Flaws, Jodi A

    2013-01-01

    Di-n-butyl phthalate (DBP) is present in many consumer products, such as infant, beauty, and medical products. Several studies have shown that DBP causes reproductive toxicity in rodents, but no studies have evaluated its effects on ovarian follicles. Therefore, we used a follicle culture system to evaluate the effects of DBP on antral follicle growth, cell cycle and apoptosis gene expression, cell cycle staging, atresia, and 17β-estradiol (E(2)) production. Antral follicles were isolated from adult CD-1 mice and exposed to DBP at 1, 10, 100, and 1000 μg/ml for 24 or 168 h. Follicles treated with vehicle or DBP at 1-100 μg/ml grew over time, but DBP at 1000 μg/ml significantly suppressed follicle growth. Regardless of effect on follicle growth, DBP-treated follicles had decreased mRNA for cyclins D2, E1, A2, and B1 and increased p21. Levels of the proapoptotic genes Bax, Bad, and Bok were not altered by DBP treatment, but DBP 1000 μg/ml increased levels of Bid and decreased levels of the antiapoptotic gene Bcl2. DBP-treated follicles contained significantly more cells in G(1) phase, significantly less cells in S, and exhibited a trend for fewer cells in G(2). Although DBP did not affect E(2) production and atresia at 24 h, follicles treated with DBP had reduced levels of E(2) at 96 h and underwent atresia at 168 h. These data suggest that DBP targets antral follicles and alters the expression of cell cycle and apoptosis factors, causes cell cycle arrest, decreases E(2), and triggers atresia, depending on dose. PMID:23242528

  18. Wide Field Multiband Imaging of Low Redshift Quasar Environments

    NASA Astrophysics Data System (ADS)

    Scott, Jennifer E.; Rafiee, Alireza; Bechtold, Jill; Ellingson, Erica; Thibodeau, Christopher; Richmond, Michael

    2015-02-01

    We present photometry of the large-scale environments of a sample of 12 broad line active galactic nuclei (AGNs) with 0.06 < z < 0.37 from deep images in the Sloan Digital Sky Survey u, g, r, and i filters taken with the 90Prime prime focus camera on the Steward Observatory Bok Telescope. We measure galaxy clustering around these AGNs using two standard techniques: correlation amplitude (B gq) and the two point correlation function. We find average correlation amplitudes for the 10 radio-quiet objects in the sample equal to (9 ± 18, 144 ± 114, -39 ± 56, 295 ± 260) Mpc1.77 in (u, g, r, i), all consistent with the expectation from galaxy clustering. Using a ratio of the galaxy-quasar cross-correlation function to the galaxy autocorrelation function, we calculate the relative bias of galaxies and AGNs, b gq. The bias in the u band, b gq = 3.08 ± 0.51 is larger compared to that calculated in the other bands, but it does not correlate with AGN luminosity, black hole mass, or AGN activity via the luminosity of the [O III] emission line. Thus ongoing nuclear accretion activity is not reflected in the large scale environments from ~10 h -1 kpc to ~0.5 h -1 Mpc and may indicate a non-merger mode of AGN activity and/or a significant delay between galaxy mergers and nuclear activity in this sample of mostly radio-quiet quasars.

  19. Coordinated Time Resolved Spectrophotometry of Asteroid 163249 (2002 GT)

    NASA Astrophysics Data System (ADS)

    Ryan, Erin L.; Woodward, C.; Gordon, M.; Wagner, M. R.; Chesley, S.; Hicks, M.; Pittichova, J.; Pravec, P.

    2013-10-01

    The near-Earth asteroid 163249 (2002 GT), classified as a potentially hazardous asteroid (PHA), has been identified a potential rendezvous target for the NASA Deep Impact spacecraft on 4 Jan 2020. As part of a coordinated international effort to study this asteroid during its 2013 apparition (J. Pittichová et al. DPS 2013), we obtained simultaneous Sloan r-band photometry at the Steward Observatory Bok 2.3-m telescope (+90Prime) and optical spectroscopic observations covering a wavelength interval from ~5400 to ~8500 Angstrom at the MMT 6.5-m (+RedChannel spectrograph) on 2013 June 16 and 17 UT near close Earth approach (heliocentric distance ~1.07 AU; geocentric distance ~0.13 AU) at 180 sec intervals over the ~3.76 hr rotational period. Our objective was to obtain a temporal sequence of spectra to assess surface mineralogy (seeking to potentially detect the 0.7 micron absorption bands attributed to phylosilicate materials) and to determine whether variations in the spectral slope and/or surface mineralogy are evident as a function of rotational period. Here we present initial analysis of these datasets, describing the light-curve and the reflectance spectra as a function of rotational phase. These datasets will be incorporated into a larger compendium describing the characteristics of asteroid 163249. Acknowledgement: This research supported in part by NASA 12-PAST-12-0010 grant NNX13AJ11G , and an appointment (E.L.R.) to the NASA Postdoctoral Program at the Goddard Space Flight Center, administered by Oak Ridge Associated Universities through a contract with NASA. Observations reported here were obtained at the MMT Observatory, a joint facility of the Smithsonian Institution and the University of Arizona. P.P. was supported by the Grant Agency of the Czech Republic, Grant P209/12/0229.

  20. [Effects of aging time on the form transformation and eco-toxicity threshold (ECx) of added Zn in typical China soils].

    PubMed

    Lin, Lei; Chen, Shi-Bao; Liu, Ji-Fang; Ma, Yi-Bing

    2013-07-01

    Six typical China soils with different properties were selected and added with seven concentrations of ZnCl2 to study the effects of different aging time (14, 90, 180, 360, and 540 days) on the form transformation and eco-toxicity threshold (ECx) of added Zn in the soils, with the main affecting factors analyzed. The results indicated that with the increase of aging time, the fraction of 0.01 mol x L(-1) CaCl2-extracted Zn in the soils decreased sharply initially, then slowed down, and reached the dynamic balance after 540 d incubation. The eco-toxicity thresholds (ECx, x = 10, 50) of Zn to bok choy increased significantly with aging time (P < 0.05), which implied the marked decrease of the phyto-toxicity of Zn. The measured aging factors AF10 and AF50 of Zn ranged from 1.077-1.743 and 1.174-1.441, respectively, and increased with aging time. The balanced concentration of Zn in the soils was significantly negatively correlated with soil pH, CEC, and organic carbon (Org-C) content, and soil pH was the most important controlling factor, followed by CEC and Org-C. It took shorter time to reach Zn balance in the soils with higher pH. The prediction model of the ECx of Zn was developed based on the aging factors and the main soil properties, and could be well validated by the measured ECx under field condition. This study would provide theoretical basis for the normalization of the eco-toxicity thresholds of added Zn in different soils and the formulation of the environmental criterion of Zn in China soils. PMID:24175536

  1. Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China.

    PubMed

    Fowke, Jay H; Shu, Xiao-Ou; Dai, Qi; Shintani, Ayumi; Conaway, C Clifford; Chung, Fung-Lung; Cai, Qiuyin; Gao, Yu-Tang; Zheng, Wei

    2003-12-01

    Alternative measures of Brassica vegetable consumption (e.g., cabbage) may clarify the association between Brassica and cancer risk. Brassica isothiocyanates (ITCs) are excreted in urine and may provide a sensitive and food-specific dietary biomarker. However, the persistence of ITCs in the body may be brief and dependent on the activity of several Phase II enzymes, raising questions about the relationship between a single ITC measure and habitual dietary patterns. This study investigates the association between urinary ITC excretion and habitual Brassica consumption, estimated by a food frequency questionnaire, among healthy Chinese women enrolled in the Shanghai Breast Cancer Study. Participants (n = 347) completed a validated food frequency questionnaire querying habitual dietary intake during the prior 5 years and provided a fasting first-morning urine specimen. Genetic deletion of glutathione S-transferases (GSTM1/GSTT1), and single nucleotide substitutions in GSTP1 (A313G) and NAD(P)H:quinone oxidoreductase 1 (NQO1: C609T), were identified from blood DNA. Urinary ITC excretion levels were marginally higher with the GSTT1-null or GSTP1-G/G genotypes (P = 0.07, P = 0.05, respectively). Mean habitual Brassica intake was 98.3 g/day, primarily as bok choy, and Brassica intake significantly increased across quartile categories of ITC levels. The association between habitual Brassica intake and urinary ITC levels was stronger among women with GSTT1-null or GSTP1-A/A genotypes, or NQO1 T-allele, and the interaction was statistically significant across GSTP1 genotype. In conclusion, a single urinary ITC measure, in conjunction with markers of Phase II enzyme activity, provides a complementary measure of habitual Brassica intake among Shanghai women. PMID:14693750

  2. Plant growth inhibition by cis-cinnamoyl glucosides and cis-cinnamic acid.

    PubMed

    Hiradate, Syuntaro; Morita, Sayaka; Furubayashi, Akihiro; Fujii, Yoshiharu; Harada, Jiro

    2005-03-01

    Spiraea thunbergii Sieb. contains 1-O-cis-cinnamoyl-beta-D-glucopyranose (CG) and 6-O-(4'-hydroxy-2'-methylene-butyroyl)-1-O-cis-cinnamoyl-beta-D-glucopyranose (BCG) as major plant growth inhibiting constituents. In the present study, we determined the inhibitory activity of CG and BCG on root elongation of germinated seedlings of lettuce (Lactuca sativa), pigweed (Amaranthus retroflexus), red clover (Trifolium pratense), timothy (Phleum pratense), and bok choy (Brassica rapa var chinensis) in comparison with that of two well-known growth inhibitors, 2,4-dichlorophenoxyacetic acid (2,4-D) and (+)-2-cis-4-trans-abscisic acid (cis-ABA), as well as two related chemicals of CG and BCG, cis-cinnamic acid (cis-CA) and trans-cinnamic acid (trans-CA). The EC50 values for CG and BCG on lettuce were roughly one-half to one-quarter of the value for cis-ABA. cis-Cinnamic acid, which is a component of CG and BCG, possessed almost the same inhibitory activity of CG and BCG, suggesting that the essential chemical structure responsible for the inhibitory activity of CG and BCG is cis-CA. The cis-stereochemistry of the methylene moiety is apparently needed for high inhibitory activity, as trans-CA had an EC50 value roughly 100 times that of CG, BCG, and cis-CA. Growth inhibition by CG, BCG, and cis-CA was influenced by the nature of the soil in the growing medium: alluvial soil preserved the bioactivity, whereas volcanic ash and calcareous soils inhibited bioactivity. These findings indicate a potential role of cis-CA and its glucosides as allelochemicals for use as plant growth regulators in agricultural fields. PMID:15898503

  3. Near-IR Spectral Variability of Young Stars

    NASA Astrophysics Data System (ADS)

    Zajac, Stephanie; Eisner, J. A.; Rudolph, A.

    2011-01-01

    Young stars (such as T Tauri and Herbig Ae/Be sources) exhibit photometric variability across the electromagnetic spectrum, including in the visible and infrared regions. Time-variable mass accretion rates may cause some of the observed variability, although other mechanisms such as starspots or structural changes in the circumstellar disks, provide alternative explanations. Spectroscopic observations provide a means to probe accretion via diagnostic emission lines, and to probe the ratio of stellar-to-circumstellar flux via veiling of stellar absorption lines. While spectroscopic variability in the optical range has been previously investigated, variability in the near-IR has not been explored as thoroughly. We have undertaken a project to track the spectral variability of young stars in the near-IR. Using the 90-inch Bok telescope on Kitt Peak, we observed about 40 young stars with FSPEC during two five-night runs separated by one month. As this project continues, in order to extend the timescales covered by our data, we will survey the same targets under similar circumstances in the summer of 2011. Ultimately, we hope to follow a sample of about 100 young stars with five-night observing runs every month of the year. Here we present initial results showing Brackett gamma Hydrogen line emission for several sources. We show that the emission line luminosity varies, and we use this variability to constrain the mass accretion rate with time for the observed objects. We acknowledge the NSF for funding under Award No. AST-0847170, a PAARE Grant for the Calfornia-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE).

  4. Di-n-Butyl Phthalate Disrupts the Expression of Genes Involved in Cell Cycle and Apoptotic Pathways in Mouse Ovarian Antral Follicles1

    PubMed Central

    Craig, Zelieann R.; Hannon, Patrick R.; Wang, Wei; Ziv-Gal, Ayelet; Flaws, Jodi A.

    2012-01-01

    ABSTRACT Di-n-butyl phthalate (DBP) is present in many consumer products, such as infant, beauty, and medical products. Several studies have shown that DBP causes reproductive toxicity in rodents, but no studies have evaluated its effects on ovarian follicles. Therefore, we used a follicle culture system to evaluate the effects of DBP on antral follicle growth, cell cycle and apoptosis gene expression, cell cycle staging, atresia, and 17β-estradiol (E2) production. Antral follicles were isolated from adult CD-1 mice and exposed to DBP at 1, 10, 100, and 1000 μg/ml for 24 or 168 h. Follicles treated with vehicle or DBP at 1–100 μg/ml grew over time, but DBP at 1000 μg/ml significantly suppressed follicle growth. Regardless of effect on follicle growth, DBP-treated follicles had decreased mRNA for cyclins D2, E1, A2, and B1 and increased p21. Levels of the proapoptotic genes Bax, Bad, and Bok were not altered by DBP treatment, but DBP 1000 μg/ml increased levels of Bid and decreased levels of the antiapoptotic gene Bcl2. DBP-treated follicles contained significantly more cells in G1 phase, significantly less cells in S, and exhibited a trend for fewer cells in G2. Although DBP did not affect E2 production and atresia at 24 h, follicles treated with DBP had reduced levels of E2 at 96 h and underwent atresia at 168 h. These data suggest that DBP targets antral follicles and alters the expression of cell cycle and apoptosis factors, causes cell cycle arrest, decreases E2, and triggers atresia, depending on dose. PMID:23242528

  5. A Systems Engineering Approach to Quality Assurance for Aerospace Testing

    NASA Technical Reports Server (NTRS)

    Shepherd, Christena C.

    2014-01-01

    On the surface, it appears that AS9100 has little to say about how to apply a Quality Management System (QMS) to major aerospace test programs (or even smaller ones). It also appears that there is little in the quality engineering Body of Knowledge (BOK) that applies to testing, unless it is nondestructive examination (NDE), or some type of lab or bench testing associated with the manufacturing process. However, if one examines: a) how the systems engineering (SE) processes are implemented throughout a test program; and b) how these SE processes can be mapped to the requirements of AS9100, a number of areas for involvement of the quality professional are revealed. What often happens is that quality assurance during a test program is limited to inspections of the test article; what could be considered a manufacturing al fresco approach. This limits the quality professional and is a disservice to the programs and projects, since there are a number of ways that quality can enhance critical processes, and support efforts to improve risk reduction, efficiency and effectiveness. The Systems Engineering (SE) discipline is widely used in aerospace to ensure the progress from Stakeholder Expectations (the President, Congress, the taxpayers) to a successful, delivered product or service. Although this is well known, what is not well known is that these same SE processes are implemented in varying complexity, to prepare for and implement test projects that support research, development, verification and validation, qualification, and acceptance test projects. Although the test organization's terminology may vary from the SE terminology, and from one test service provider to another, the basic process is followed by successful, reliable testing organizations. For this analysis, NASA Procedural Requirements (NPR) 7123.1, NASA Systems Engineering Processes and Requirements is used to illustrate the SE processes that are used for major aerospace testing. Many of these processes

  6. Constraining the wavelength dependence of polarization for various asteroid taxonomies

    NASA Astrophysics Data System (ADS)

    Maleszewski, Chester; Smith, Paul S.; McMillan, Robert S.

    2016-10-01

    The polarization of sunlight reflected from asteroids is known to be inversely proportional to geometric albedo (Umov 1905). However, that was mainly derived from observations in the V-filter. Preliminary observations of the wavelength dependence were conducted by Belskaya et al. (2009) in the major asteroid taxonomic classes. The limited UBVRI data revealed trends of spectral slope vs. phase angle. To study the wavelength dependence of asteroid polarization more robustly, we have used the SPOL spectropolarimeter at the 2.3-m Bok and 1.6-m Kuiper telescopes. The finer spectral resolution of spectropolarimetry is needed to confirm the linearity of the wavelength dependence of polarization.We present polarization spectra from four asteroid taxonomic groups: B-, C-, S-, and X-types. Across the observed wavelength range (0.45 to 0.7 microns), the linear trend described by Belskaya et al. is confirmed and we determined the best-fit linear slope of each spectrum. For the S-type asteroids, the slope of the polarization spectra becomes more negative as the phase angle increases. The rate at which the polarization slope changes increases at phase angles greater than the inversion angle. C-type asteroids behave differently from the S-types in two ways. First, the polarization spectra for the C-types are positively sloped as opposed to negative (also noted in Belskaya et al.). Also, as you observe the C-types closer to the inversion angle (~20 degrees phase angle), the polarization slopes tend to flatten as opposed to steepen. The polarization spectra of B-type asteroids are positively sloped, but the tendency to flatten near the inversion angle like the C-type spectra is not evident. Our observations of low albedo X-types exhibit positive polarization slopes, while the high albedo observations exhibit negative slopes. Differences in the wavelength dependencies of polarization between various asteroid types appear to be driven by differences in their geometric albedos. Better

  7. The Flagstaff Meeting in June 1964

    NASA Astrophysics Data System (ADS)

    Baars, J. W. M.

    1999-05-01

    My most memorable AAS meeting is the first one, the 116th meeting in Flagstaff , AZ, June 1964. I had been at the NRAO in Green Bank for less than a year and this was going to be my first presentation at a scientific conference. I traveled with my Director, Dave Heeschen, from the newly opened Dulles Airport near Washington non stop to Tucson (try that these days of hub-hopping!). In Tucson, I was met by a friend who exposed me to a phenomenon, unknown in West Virginia: the drive-in liquor store. In those days, the AAS could comfortably meet in a small city like Flagstaff. Today this would be impossible; Flagstaff has grown slower than the AAS. I was fascinated to see and hear many astronomers, but I don't remember how my own presentation went. The most memorable event was the talk presented hors concours by Bart Bok, who had just returned from Australia to become Director of Steward Observatory. He would give an unscheduled ten minute talk on the new Anglo-Australian Telescope, but instead treated us to a most exciting story of the beauty of the Southern Sky and its astronomical wonders. He went on for 25 minutes without the Chairman daring to stop him! All following speakers were curtailed by a minute and the session finished on time. Flagstaff was, as it is now, a quiet town. There was a bar next to my motel, where I drank two Heineken every day. On the last day, there was no more Heineken. As the bar man said: `I had a six pack and you drank me out of it'. Such was the business acumen in Flagstaff in the mid sixties. Impressive was the trip to Oak Creek Canyon and Sedona, where we visited the Chapel, beautifully placed in the hills nearby. I felt the harmony between nature and building was perfect. Encroaching development, right up to the church, have taken away much of the serenity of the place. The evening flight out of Flagstaff was delayed by a summer storm. At the airport, Martin Schwarzschild chatted with me for half an hour and I was barely aware how

  8. A Survey of z>5.7 Quasars in the Sloan Digital Sky Survey. III. Discovery of Five Additional Quasars

    NASA Astrophysics Data System (ADS)

    Fan, Xiaohui; Hennawi, Joseph F.; Richards, Gordon T.; Strauss, Michael A.; Schneider, Donald P.; Donley, Jennifer L.; Young, Jason E.; Annis, James; Lin, Huan; Lampeitl, Hubert; Lupton, Robert H.; Gunn, James E.; Knapp, Gillan R.; Brandt, W. N.; Anderson, Scott; Bahcall, Neta A.; Brinkmann, Jon; Brunner, Robert J.; Fukugita, Masataka; Szalay, Alexander S.; Szokoly, Gyula P.; York, Donald G.

    2004-08-01

    We present the discovery of five new quasars at z>5.7, selected from the multicolor imaging data of the Sloan Digital Sky Survey (SDSS). Three of them, at redshifts 5.93, 6.07, and 6.22, were selected from ~1700 deg2 of new SDSS Main Survey imaging in the northern Galactic cap. An additional quasar, at redshift 5.85, was discovered by co-adding the data obtained in the Fall Equatorial Stripe in the SDSS Southern Survey Region. The fifth object, at redshift 5.80, is selected from a nonstandard SDSS scan in the southern Galactic cap outside the Main Survey area. The spectrum of SDSS J162331.81+311200.5 (z=6.22) shows a complete Gunn-Peterson trough at zabs>5.95, similar to the troughs detected in the other three z>~6.2 quasars known. We present a composite spectrum of the z>5.7 quasars discovered in the SDSS to date. The average emission-line and continuum properties of z~6 quasars exhibit no significant evolution compared with those at low redshift. Using a complete sample of nine z>5.7 quasars, we find that the density of quasars with M1450<-26.7 at z~6 is (6+/-2)×10-10 Mpc-3 (H0=65 km s-1 Mpc-1, Ω=0.35, and Λ=0.65), consistent with our previous estimates. The luminosity distribution of the sample is fitted with a power-law luminosity function Ψ(L)~L-3.2+/-0.7, somewhat steeper than but consistent with our previous estimates. Based on observations obtained with the Sloan Digital Sky Survey, and with the Apache Point Observatory 3.5 m telescope, which is owned and operated by the Astrophysical Research Consortium; and with the MMT Observatory, a joint facility of the University of Arizona and the Smithsonian Institution, with the University of Arizona 2.3 m Bok Telescope, with the Kitt Peak National Observatory 4 m Mayall Telescope, with the 6.5 m Landon Clay Telescope at the Las Campanas Observatory, a collaboration between the Observatories of the Carnegie Institution of Washington, University of Arizona, Harvard University, the University of Michigan, and

  9. Tabulation of comet observations.

    NASA Astrophysics Data System (ADS)

    1998-04-01

    Concerning comets: C/1940 R2 (Cunningham), C/1941 B2 (de Kock-Paraskevopoulos), C/1941 K1 (van Gent), C/1942 X1 (Whipple-Fedtke-Tevzadze), C/1946 C1 (Timmers), C/1946 K1 (Pajdušáková-Rotbart-Weber), C/1946 P1 (Jones), C/1946 U1 (Bester), C/1947 S1 (Bester), C/1947 X1 (Southern comet), C/1947 Y1 (Mrkos), C/1948 E1 (Pajdušáková-Mrkos), C/1948 L1 (Honda-Bernasconi), C/1948 V1 (Eclipse comet), C/1949 N1 (Bappu-Bok-Newkirk), C/1950 K1 (Minkowski), C/1951 C1 (Pajdušáková), C/1952 H1 (Mrkos), C/1952 M1 (Peltier), C/1952 Q1 (Harrington), C/1953 G1 (Mrkos-Honda), C/1953 T1 (Abell), C/1954 O1 (Vozárová), C/1955 L1 (Mrkos), C/1955 N1 (Bakharev-Macfarlane-Krienke), C/1955 O1 (Honda), C/1956 E1 (Mrkos), C/1956 R1 (Arend-Roland), C/1957 P1 (Mrkos), C/1957 U1 (Latyshev-Wild-Burnham), C/1959 Q1 (Alcock), C/1959 Q2 (Alcock), C/1959 Y1 (Burnham), C/1995 O1 (Hale-Bopp), C/1996 J1 (Evans-Drinkwater), C/1996 P2 (Russell-Watson), C/1997 BA6 (Spacewatch), C/1997 D1 (Mueller), C/1997 J1 (Mueller), C/1997 J2 (Meunier-Dupouy), C/1997 N1 (Tabur), C/1997 T1 (Utsunomiya), 10P/Tempel 2, 21P/Giacobini-Zinner, 29P/Schwassmann-Wachmann 1, 43P/Wolf-Harrington, 55P/Tempel-Tuttle, 62P/Tsuchinshan 1, 69P/Taylor, 78P/Gehrels 2, 81P/Wild 2, 88P/Howell, 95P/Chiron, 103P/Hartley 2, 104P/Kowal 2, 111P/Helin-Roman-Crockett, 118P/Shoemaker-Levy 4, 121P/Shoemaker-Holt 2, 129P/Shoemaker-Levy 3, 134P/Kowal-Vavrova, P/1997 C1 (Gehrels), P/1997 G1 (Montani).

  10. X-ray fluorescence (XRF) scanning of discrete samples: Examples from the loess-paleosol sequence on the Island of Susak, Croatia

    NASA Astrophysics Data System (ADS)

    Profe, Jörn; Wacha, Lara; Frechen, Manfred; Rolf, Christian; Brlek, Mihovil; Ohlendorf, Christian; Zolitschka, Bernd

    2016-04-01

    Loess-paleosol sequences (LPS) are recognized as valuable terrestrial environmental archives. Although LPS provide discontinuous archives, high-resolution sampling and analyzing strategies are required for a sound reconstruction of past environmental conditions. Up to now, proxies such as grain size, rock magnetic properties and calcium-carbonate content are commonly investigated at the centimeter scale, whereas the elemental as well as the mineralogical compositions are analyzed at a much coarser resolution, e.g. with 10 cm intervals or once for every lithological unit. X-ray fluorescence (XRF) scanning of discrete powdered and homogenized samples is a new application of the XRF core-scanner technology providing a tool for fast and non-destructive qualitative measurement of the elemental composition along LPS. Tracking relative changes of the elemental distribution at the centimeter scale is considered as an important supplement to existing methods applied to LPS in order to gain a more detailed knowledge about weathering, dust provenance and sedimentation dynamics. The island of Susak, situated in the north-eastern Adriatic Sea, represents an exceptional site with Pleistocene aeolian sediments of up to 90 m thickness covering at least the last glacial-interglacial cycle. The studied sub-profiles are part of loess cliffs located directly on the coast of Susak (Bok-Bay). Therefore, this record qualifies as a test candidate for benchmarking XRF scanning of discrete samples against magnetic susceptibility, organic carbon and lithological data. The following elements are studied as proxies for weathering (K, Ca, Sr, Rb), for dust provenance (Al, Si, Ti, Zr) and for organic matter (S, Br). In addition, Fe is directly linked to magnetic susceptibility. First results indicate a general agreement between lithologically identified paleosols and element weathering indices. Fe is predominantly positively correlated with magnetic susceptibility. The Ti/Zr-ratio points to a

  11. Extended Lyα Nebulae at z ≃ 2.3: An Extremely Rare and Strongly Clustered Population?

    NASA Astrophysics Data System (ADS)

    Yang, Yujin; Zabludoff, Ann; Tremonti, Christy; Eisenstein, Daniel; Davé, Romeel

    2009-03-01

    To obtain an unbiased sample of bright Lyα blobs (L_{Lyα} ≳ 10^{43} erg s-1), we have undertaken a blind, wide-field, narrowband imaging survey in the National Optical Astronomy Observatory Deep Wide Field Survey Boötes field with the Steward Bok 2.3 m telescope. After searching over 4.82 deg2 at z = 2.3, we discover four Lyα blobs with L_{Lyα} = 1.6-5.3 × 1043 erg s-1, isophotal areas of 28-57 ⊓⊔, and broad Lyα line profiles (Δv = 900-1250 km s-1). In contrast with the extended Lyα halos associated with high-z radio galaxies, none of our four blobs are radio-loud. The X-ray luminosities and optical spectra of these blobs are diverse. Two blobs (3 and 4) are X-ray detected with LX (2-7 keV) = 2-4 × 1044 erg s-1 and have broad optical emission lines (C IV) characteristic of active galactic nucleus (AGN), implying that 50% of our sample blobs are associated with a strong AGN. The other 50% of the blobs (1 and 2) are not X-ray or optically detected as AGN down to similar limits. The number density of the four blobs is ~3 × 10-6 h 3 70 Mpc-3, comparable to that of galaxy clusters at similar redshifts and 3× lower than that found in the SSA22 proto-cluster at z = 3.1, even after accounting for the over-density of that region. The two X-ray undetected blobs are separated by only 70'' (550 kpc) and have almost identical redshifts (lsim360 kpc along the line of sight), suggesting that they are part of the same system. Given the rarity of the blobs and our discovery of a close pair, we speculate that blobs occupy the highest density regions and thus may be precursors of today's rich-cluster galaxies. Observations reported here were obtained at the MMT Observatory, a joint facility of the University of Arizona and the Smithsonian Institution.

  12. Spectropolarimetry of B-type and C-type asteroids: Phase Curves and Wavelength Dependence

    NASA Astrophysics Data System (ADS)

    Maleszewski, C.; McMillan, R. S.; Smith, P. S.

    2014-12-01

    We present recent spectropolarimetric observations of eleven B- and C-type asteroids using SPOL (http://james.as.arizona.edu/~psmith/SPOL/) at the 2.3-m Bok and 1.6-m Kuiper telescopes. Our primary goal is to further constrain our understanding of the wavelength dependence of linear polarization. For each object, we produced polarimetric phase curves (linear polarization vs. phase angle) and measure the wavelength dependence in each observation by calculating the slope of each polarization spectrum. Previous analysis by Belskaya et al. (2009) shows that the slope of the polarization spectrum increases as the wavelength increases. No analysis of the wavelength dependence in B-types has occurred previously to our knowledge. For the five C-type (3 Ch- and 2 C-) objects observed, those of the Ch-type have larger minimum polarizations than of the C- subtype. This is consistent with polarimetric phase curves of similar asteroids by Gil-Hutton and Cañada-Assandri (2012). With respect to the wavelength dependence, our observed targets show an increase in polarization slope with wavelength, confirming the Belskaya (2009) result. After dividing the data by group, C- subtype objects have relatively flat polarization spectra, as opposed to the Ch- subtypes that have more rapidly changing slopes as phase angle increases. A mineralogical basis for the variety of wavelength dependences observed is most likely. Additional observations of the other C- subtypes will aid to distinguish how mineralogical variation affects polarization. It may also explain the wide range of polarization slopes measured near a phase angle of ten degrees in the Belskaya (2009) analysis. Six B-type asteroids were observed in a similar manner. As with the C-types, the polarimetric phase curves vary in shape, suggesting differences in albedo. Also, the wavelength dependence increases with wavelength, as shown for the C-types. On the other hand, all of the B-type objects have a similar wavelength dependence

  13. Physical characterization of fast rotator NEOs

    NASA Astrophysics Data System (ADS)

    Kikwaya Eluo, Jean-Baptiste; Hergenrother, Carl W.

    2015-08-01

    Understanding the physical characteristics of fast rotator NEOs (sub-km sizes with H > 22) is important for two reasons: to establish properties that can constraint models of their potential hazard, and to learn about the origin and the evolution of the solar system. Technically it is difficult to cover different ranges of wavelengths using one telescope with one instrument. Setting up a network of telescopes with different instruments observing simultaneously the same object will efficiently contribute to the characterization of NEOs.ART (Arizona Robotic Telescope) is a University of Arizona initiative whose goal is to use local 2-m size telescopes to provide near real-time observations of Target of Opportunity objects covering the visible and the near- infrared wavelengths. We plan to use three telescopes of the ART project to observe fast rotator NEOs: 1) VATT (Vatican Advanced Technology Telescope) at Mount Graham (longitude: -109.8719, latitude: 32.7016, elevation: 10469 feet) with VATT-4K optical imager for photometry to estimate colors, lightcurves to get the rotation rate, and estimate the phase angle function of NEOs, 2) Bok 2.3 m at Kitt Peak (longitude: -111.6004, latitude: 31.9629, elevation: 6795 feet) with BCSpec (Boller & Chivens Spectrograph) for visible spectroscopy, and 3) Kuiper 1.5-m at Mount Bigelow (longitude: -110.7345, latitude: 32.4165, elevation: 8235 feet) with a near-infrared instrument.We report here the preliminary results of several NEOs whose rotation rate, color, and type have been estimated using photometry with images recorded with VATT-4K. 2009 SQ104 has a rotation rate of 6.85+/- 0.03 h, 2014 AY28 has a rotation rate of 0.91 +/- 0.02 h, 2014 EC of 0.54 +/-0.04 h, 2014 FA44 of 3.45 +/- 0.05 h, 2014 KS40 of 1.11 +/- 0.06 h, 2011 PT of 0.17 +/- 0.05 h, 2014 SC324 of 0.36 +/- 0.43 h, 2014 WF201 of 1.00 +/- 0.03 h. Of these objects, 2014 HM2, 2014 FA, 2014 SB145, 2011 PT fall among X-type asteroids; 2014 KS, 2014 WF are likely to be

  14. Tentative critical levels of tropospheric ozone for agricultural crops in Japan

    NASA Astrophysics Data System (ADS)

    Yonekura, T.

    2010-12-01

    Ground level ozone concentrations have increased year by year in Japan. High ozone concentrations have been known to affect growth and yield of agricultural crops. In the US and Europe, much effort has been directed to establish regulatory policies such as secondary air quality standard and critical levels to protect vegetation against ozone. On the contrary, in Japan, there is a few data of agricultural crops sensitivity to ozone. Furthermore, there is no information about the ozone risk of agricultural crop loss by based on ozone index (e.g. AOT40, SUM06, W126)-crop response relationship, yet. The objects of our research are: (1) to screen sensitivity of ozone on 10 crops cultivated in urban area in Japan. (2) to establish critical levels of ozone for protecting agricultural crops based on ozone index-crop response relationship. The 10 Japanese agricultural crops such as Japanese rice, Hanegi (Welsh onion), Shungiku (Crown daisy), Saradana (Lettus), Hatsukadaikon (Radish), Kokabu (Small Turnip), Santosai (Chinese cabbage), Tasai (Spinach mustard), Komatsuna (Japanese mustard spinach) and Chingensai (Bok Choy), were fumigated to three levels of ozone (clean air (< 5 ppbv), ambient level of ozone, 1.5 times ambient ozone) in open-top chambers during 30 to 120 days. Those experiments were repeated five times during two growing season. Throughout the experimental period, the growth or yield were measured, and the relationship between growth (or yield) and ozone index was examined. As a result, the influences of ozone on growth or yield were different among 10 crops. Relatively good correlations of coefficients of determination (r2) for linear regressions to growth or yield were obtained with “8h means” and “AOT40” rather than “SUM00”, “SUM06” and “W126”. Critical level for 10 crops in terms of an AOT40 were 1.1 to 2.1 ppm h per month. The ozone sensitive crop in our study was sound to be 1.0 ppm h per month in AOT40.

  15. Molecular and Histopathological Changes in Mouse Intestinal Tissue after Proton Exposure

    NASA Astrophysics Data System (ADS)

    Purgason, Ashley; Zhang, Ye; Hamilton, Stanley; Wu, Honglu

    Radiation in space, especially energetic protons emitted from solar particle events (SPEs), poses serious health risks to astronauts and is especially dangerous for long duration missions. Protons are the most abundant particles in space and to date there is little known about the details of the negative consequences crew members will face upon exposure to them. To elucidate some of the possible health effects induced by protons, BALB/C mice were subjected to 250 MeV of proton radiation at doses of 0 Gy, 0.1 Gy, 1 Gy, and 2 Gy. Three specimens per dose were studied. The gastrointestinal tract of each animal was dissected four hours post-irradiation and the isolated small intestinal tissue was fixed in formalin for histopathological examination or snap-frozen in liquid nitrogen for RNA isolation. Histopathologic observation of the tissue using standard HE staining methods to screen for morphologic changes showed a marked increase in apoptotic lesions for even the lowest dose of 0.1 Gy, and the dose response showed possible hyper sensitivities at low dose. Tissue of the gastrointestinal tract was also homogenized and RNA was isolated for cDNA synthesis and real-time PCR analysis for genes involved in apoptosis. Results of gene expression changes revealed consistent up or down regulation of a number of genes for all of the exposure doses that may play a role in proton-induced apoptosis (e.g. Hsp90ab1). In addition, several genes were found to have significant changes in the RNA level after only the low dose (0.1 Gy), but not the high dose (1 and 2 Gy), proton exposures (e.g. Bok and Casp1), whereas some genes had expression changes only after high dose proton exposures (e.g. Tsc22d3). These findings demonstrated that apoptosis may occur in gastrointestinal tracts after even low dose proton exposures, and the different gene expression patterns between low and high dose proton irradiated mice may offer insight into the molecular mechanisms of the possible hyper

  16. Increasing the Output of Spacewatch Astrometry of Near-Earth Asteroids

    NASA Astrophysics Data System (ADS)

    McMillan, Robert S.; Bressi, Terrence H.; Larsen, Jeffrey A.; Mastaler, Ronald A.; Read, Michael T.; Tubbiolo, Andrew F.; Scotti, James V.

    2016-10-01

    The Spacewatch Project at the University of Arizona specializes in followup astrometry of Near-Earth Asteroids (NEAs) when they are fainter than most other followup stations can reach. Priority is given to objects on the Confirmation Page of the Minor Planet Center (MPC), potential impactors on the Earth, objects requested by the Jet Propulsion Laboratory (JPL), future targets of radar, objects whose infrared flux or taxonomic properties have been measured, potential destinations of spacecraft, and objects being monitored for Yarkovsky drift. Upgrades in hardware, software, and observing procedures since 2015 Sept have boosted the numbers of observations of NEAs we make with the 0.9-m, 1.8-m, and 2.3-m telescopes on Kitt Peak in Arizona. Targeting specific NEAs with our 0.9-m telescope (site code 691) down to V magnitude 22 has increased the rate of observations of NEAs by a factor of 3.9 compared to the previous survey pattern. Comparing the first three months of 2016 with the same period in 2015 our 1.8-m telescope (site code 291) shows a 25% increase in total images acquired, a 35% increase in shutter-open exposure time, a 68% increase in the number of PHAs observed down to R magnitude 22.5, and a 105% increase in the number of PHAs observed with magnitudes >= 21.5. Installation of our new CCD camera at the Cassegrain focus of the Bok 2.3-meter telescope of Steward Observatory (site code ^695) and better software have allowed 50% more targeted objects per night down to R magnitude 23 and a 303% increase in the number of images taken per night. In the time interval reported, Spacewatch observed 41% of all the NEAs that were observed by anyone and 44% of all the PHAs that were observed by anyone. We also contributed 19% of all the astrometry of PHAs that were fainter than magnitude 22. Support of Spacewatch is from NASA/NEOO grants, the Lunar and Planetary Laboratory, Steward Observatory, Kitt Peak National Observatory, the Brinson Foundation of Chicago, IL, the

  17. THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

    SciTech Connect

    Shen, Yue; Brandt, W. N.; Dawson, Kyle S.; Hall, Patrick B.; McGreer, Ian D.; Fan, Xiaohui; Anderson, Scott F.; Chen, Yuguang; Denney, Kelly D.; Eftekharzadeh, Sarah; Gao, Yang; Green, Paul J.; Greene, Jenny E.; Ho, Luis C.; Horne, Keith; Kelly, Brandon C.; and others

    2015-01-01

    The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg{sup 2} field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i {sub psf} = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bands was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science.

  18. Planetary Doppler Imaging

    NASA Astrophysics Data System (ADS)

    Murphy, N.; Jefferies, S.; Hart, M.; Hubbard, W. B.; Showman, A. P.; Hernandez, G.; Rudd, L.

    2014-12-01

    from space, however, much can be learned about Jupiter and Saturn using ground-based measurements. We will present the first results from a ground-based observing campaign of Jupiter and Saturn, made from the Bok 90" telescope on Kitt Peak, intended to validate the work of Gaulme et al, and extend such observations to Saturn.

  19. Spitzer and HHT observations of the earliest stages of star formation

    NASA Astrophysics Data System (ADS)

    Stutz, Amelia M.

    We use Spitzer Space Telescope and Heinrich Hertz Telescope (HHT) observations to study the earliest stages of low-mass star formation. Using spatially resolved absorption features, termed shadows, we study the cold cloud cores where stars form. We study Barnard 335, a prototypical isolated Bok globule with an embedded Class 0 protostar. We discover an 8 mm shadow in the inner regions of the core; using this feature we measure the dense core structure and mass. Using HHT observations we detect a rotating structure, a flattened molecular core, with a diameter ~10,000 AU. The flattened molecular core is likely to be the same structure as that generating the 8 mm shadow, and is expected from theoretical simulations. This structure has not been robustly detected in previous observations although there have been some prior indications of its presence. We study dense starless core structure through longer wavelength observations of shadows; we present Spitzer observations of 8 mm, 24 mm, and 70 mm shadows of 14 cores in total. Combined with HHT observations of 12 CO 2-1 and 13 CO2- 1, we derive core sizes, masses, study core structure, and investigate the collapse status of each core. Our study of starless core CB190 reveals that the core is likely to be stable against collapse if magnetic pressure is present at a reasonable level in the core. Our study of the 70 mm shadow associated with the starless core L429 reveals that this object is very likely to be collapsing. Finally, we study a sample of 12 starless cores selected to have prominent 24 mm shadows. We find that about 2/3 of these sources are likely to be collapsing. Additionally, we find indications that 1/2 of the cores revealed to be collapse candidates show indications of having 70 mm shadows. We conclude that all cores dense enough to produce 70 mm shadows are collapse candidates, and that the presence of a shadow at 24 mm is an indicator that the core is likely ([Special characters omitted.] 60% probability

  20. Obituary: Allan R. Sandage (1926-2010)

    NASA Astrophysics Data System (ADS)

    Devorkin, David

    2011-12-01

    Weart on 22 May 1978, Niels Bohr Library & Archives, American Institute of Physics, College Park, MD, USA, www.aip.org/history/ohilist/ and http://www.aip.org/history/ohilist/4380_1.html] Allan enrolled in Miami University in 1943 because his father was on the faculty there at the time. He majored in physics until he entered the Navy for 18 months to train as an electronics technician's mate. His training began in Chicago, where he became acquainted with others interested in astronomy, like Arthur Code and Albert Wilson, and then his tour took him to Gulfport, Mississippi, and finally to Treasure Island in the San Francisco Bay. When Sandage was discharged from the Navy his father was moving to the University of Illinois, so Allan transferred there, entering a much larger and more competitive physics department. He majored in physics and mathematics but he also minored in philosophy, and took a celestial mechanics course from Robert H. Baker. He volunteered to work at the observatory, learning the art and craft of calibrating photographic plates so that magnitudes could be transferred and intercompared from plate to plate, an experience that he later realized prepared him well for his life career and also introduced him into Bart Bok's "star counting" circuit based at Harvard. In consequence, when Bok visited Illinois sometime in 1947, he invited Sandage to work at Harvard in their summer school at the Agassiz Station mapping Milky Way fields. Sandage applied both to Harvard and Caltech for graduate school. Harvard was very well established in its graduate program whereas Caltech was just beginning to offer the Ph.D. in astronomy. He chose Caltech because that was where the big telescopes were. His family had visited Mount Wilson in 1941 during a summer when his father was teaching at Berkeley, and since that time Sandage had dreamed of observing with those giant telescopes. Thus in September 1948, Sandage joined the first class of students to engage in formal graduate

  1. VISTA Stares Deeply into the Blue Lagoon

    NASA Astrophysics Data System (ADS)

    2011-01-01

    This new infrared image of the Lagoon Nebula was captured as part of a five-year study of the Milky Way using ESO's VISTA telescope at the Paranal Observatory in Chile. This is a small piece of a much larger image of the region surrounding the nebula, which is, in turn, only one part of a huge survey. Astronomers are currently using ESO's Visible and Infrared Survey Telescope for Astronomy (VISTA) to scour the Milky Way's central regions for variable objects and map its structure in greater detail than ever before. This huge survey is called VISTA Variables in the Via Lactea (VVV) [1]. The new infrared image presented here was taken as part of this survey. It shows the stellar nursery called the Lagoon Nebula (also known as Messier 8, see eso0936), which lies about 4000-5000 light-years away in the constellation of Sagittarius (the Archer). Infrared observations allow astronomers to peer behind the veil of dust that prevents them from seeing celestial objects in visible light. This is because visible light, which has a wavelength that is about the same size as the dust particles, is strongly scattered, but the longer wavelength infrared light can pass through the dust largely unscathed. VISTA, with its 4.1-metre diameter mirror - the largest survey telescope in the world - is dedicated to surveying large areas of the sky at near-infrared wavelengths deeply and quickly. It is therefore ideally suited to studying star birth. Stars typically form in large molecular clouds of gas and dust, which collapse under their own weight. The Lagoon Nebula, however, is also home to a number of much more compact regions of collapsing gas and dust, called Bok globules [2]. These dark clouds are so dense that, even in the infrared, they can block the starlight from background stars. But the most famous dark feature in the nebula, for which it is named, is the lagoon-shaped dust lane that winds its way through the glowing cloud of gas. Hot, young stars, which give off intense

  2. VISTA Stares Deeply into the Blue Lagoon

    NASA Astrophysics Data System (ADS)

    2011-01-01

    This new infrared image of the Lagoon Nebula was captured as part of a five-year study of the Milky Way using ESO's VISTA telescope at the Paranal Observatory in Chile. This is a small piece of a much larger image of the region surrounding the nebula, which is, in turn, only one part of a huge survey. Astronomers are currently using ESO's Visible and Infrared Survey Telescope for Astronomy (VISTA) to scour the Milky Way's central regions for variable objects and map its structure in greater detail than ever before. This huge survey is called VISTA Variables in the Via Lactea (VVV) [1]. The new infrared image presented here was taken as part of this survey. It shows the stellar nursery called the Lagoon Nebula (also known as Messier 8, see eso0936), which lies about 4000-5000 light-years away in the constellation of Sagittarius (the Archer). Infrared observations allow astronomers to peer behind the veil of dust that prevents them from seeing celestial objects in visible light. This is because visible light, which has a wavelength that is about the same size as the dust particles, is strongly scattered, but the longer wavelength infrared light can pass through the dust largely unscathed. VISTA, with its 4.1-metre diameter mirror - the largest survey telescope in the world - is dedicated to surveying large areas of the sky at near-infrared wavelengths deeply and quickly. It is therefore ideally suited to studying star birth. Stars typically form in large molecular clouds of gas and dust, which collapse under their own weight. The Lagoon Nebula, however, is also home to a number of much more compact regions of collapsing gas and dust, called Bok globules [2]. These dark clouds are so dense that, even in the infrared, they can block the starlight from background stars. But the most famous dark feature in the nebula, for which it is named, is the lagoon-shaped dust lane that winds its way through the glowing cloud of gas. Hot, young stars, which give off intense

  3. Obituary: Frank K. Edmondson (1912-2008)

    NASA Astrophysics Data System (ADS)

    Pilachowski, Catherine A.; Olson, Margaret K. Edmondson; Edmondson, Frank K., Jr.

    2009-12-01

    Pluto's status to a dwarf planet. While in Flagstaff, Frank met Margaret Russell, the youngest daughter of famed American astronomer Henry Norris Russell of Princeton University. The young couple instantly bonded and became engaged after only two weeks. He and Margaret were married on November 24, 1934. Frank and Margaret remained inseparable until her death in 1999, always together at meetings of the American Astronomical Society, the International Astronomical Union, and elsewhere. Studying under astronomer Bart Bok, Frank received his Ph.D. in astronomy in 1937 from Harvard University, where he completed his dissertation on "The Absorption of Light in the Galaxy," and joined the faculty as an Instructor in Astronomy at Indiana University. Frank became the second member of the Astronomy Department, with Professor W. A. Cogshall, housed in Kirkwood Observatory. Frank served as chair of the department from 1944 until 1978. Under his leadership, the University acquired the Goethe Link Observatory in Brooklyn, IN, (a gift from Dr. Goethe Link, a noted Indianapolis physician and avid amateur astronomer), established a graduate program in astronomy, and enlarged the Department of Astronomy from two faculty members to eight. In one of his favorite stories, Edmondson bet Professor Cogshall a chocolate ice cream cone that President Herman B Wells would fund a new position for the Department, knowing full well that Wells had already agreed. Frank retired from IU in 1983. Studying under astronomer Bart Bok, Frank received his Ph.D. in astronomy in 1937 from Harvard University, where he completed his dissertation on "The Absorption of Light in the Galaxy," and joined the faculty as an Instructor in Astronomy at Indiana University. Frank became the second member of the Astronomy Department, with Professor W. A. Cogshall, housed in Kirkwood Observatory. Frank served as chair of the department from 1944 until 1978. Under his leadership, the University acquired the Goethe Link

  4. How to Become a Star

    NASA Astrophysics Data System (ADS)

    2001-01-01

    ESO Telescopes Provide Most Detailed View Ever Into a Dark Cloud Summary How do stars like our Sun come into being? Which fundamental processes are responsible for transforming a dark and diffuse interstellar cloud of gas and dust into a much denser, shining object? Astronomers have just taken an important step towards answering this fundamental question. Based on the most detailed study ever made of the internal structure of a small interstellar cloud, three scientists from ESO and the USA [1] have found that it is apparently on the verge of becoming unstable - and thus in the stage immediately preceding a dramatic collapse into a dense and hot, low-mass star. Interestingly, the current structure of this cloud, a "Bok globule" known as Barnard 68 (B68) [2], is governed by the same basic physics as is that of a star. The cloud is obviously in a temporary state of near-equilibrium, where the inward force of gravity caused by its mass more or less balances that of the outward pressure due to its temperature. But this situation may not last long. The astronomers believe that this particular cloud, together with some others in the same galactic neighbourhood, constitute the few resistent remains of a much larger cloud that has disappeared due to the influence of strong stellar winds and ultraviolet radiation from young and heavy stars as well as supernova explosions. The new and unique insight into the pre-collapse phase of the complicated process of stellar birth is based on observations made with ESO telescopes at the La Silla and Paranal observatories in Chile. PR Photo 02a/01 : The Bok Globule B68 , as seen in visual light. PR Photo 02b/01 : Looking through the Bok Globule B68 . PR Photo 02c/01 : A comparison of the visual and infrared views of the Bok Globule B68 . From Dark Clouds to Stars Astronomers have known for some time that stars like our Sun are formed from interstellar clouds of gas and dust. When they contract, the interior temperature rises. If the

  5. Did the Malaysian Main Range record a weak hot Mega Shear?

    NASA Astrophysics Data System (ADS)

    Sautter, Benjamin; Pubellier, Manuel

    2015-04-01

    The Main Range of Peninsular Malaysia is a batholith that extends over more than 500km from Malacca in the South to the Thailand border in the North. It results from the subduction/accretion history of the western margin of Sunda Plate by Late Triassic times. We present a structural analysis based on geomorphology, field observations and geochronological data. While most of the basement fabrics are characterized by N-S structures such as granitic plutons, sutures, and folds, a prominent oblique deformation occurred by the End of the Mesozoics synchronous with a widespread thermal anomaly (eg Tioman, Stong, Gunung Jerai, Khanom, Krabi plutons). Morphostructures and drainage anomalies from Digital Elevation Model (SRTM and ASTER), allow us to highlight 2 major groups of penetrative faults in the Central Range Batholith: early NW-SE (5km spaced faults some of which are identified as thrust faults) cross-cut and offset by NNE-SSW dextral normal faults. The regularly spaced NW-SE faults bend toward the flanks of the Batholith and tend to parallel both the Bentong Raub Suture Zone to the East and the strike slip Bok Bak Fault to the West, thus giving the overall fault network the aspect of a large C/S band. Hence, a ductile/brittle behavior can be proposed for the sigmoid faults in the core of the Batholith, whereas the NNE faults are clearly brittle, more linear and are found on the smaller outlying plutons. Radiogenic crystallization ages are homogenous at 190±20Ma (U-Pb Zircon, Tc>1000°C and K-Ar Muscovite, Tc350°C) whereas Zircon fission tracks(Tc=250°C) show specific spatial zoning of the data distribution with ages at 100±10Ma for the outlying plutons and ages at 70±10Ma for the Main Range. We propose a structural mechanism according to which the Main Range would be the ductile core of a Mega-Shear Zone exhumed via transpressive tectonics by the end of Mesozoic Times. A first stage between 100 and 70Ma (Upper Cretaceous) of dextral transpression affected

  6. Rotation and color properties of the nucleus of Comet 2P/Encke

    NASA Astrophysics Data System (ADS)

    Lowry, Stephen C.; Weissman, Paul R.

    2007-05-01

    We present results from CCD observations of Comet 2P/Encke acquired at Steward Observatory's 2.3 m Bok Telescope on Kitt Peak. The observations were carried out in October 2002 when the comet was near aphelion. Rotational lightcurves in B-, V-, and R-filters were acquired over two nights of observations, and analysed to study the physical and color properties of the nucleus. The average apparent R-filter magnitude across both nights corresponds to a mean effective radius of 3.95±0.06 km, and this value is similar to that found for the V- and B-filters. Taking the observed brightness range, we obtain a/b⩾1.44±0.06 for the semi-axial ratio of Encke's nucleus. Applying the axial ratio to the R-filter photometry gives nucleus semi-axes of [3.60±0.09]×[5.20±0.13] km, using the empirically-derived albedo and phase coefficient. No coma or tail was seen despite deep imaging of the comet, and flux limits from potential unresolved coma do not exceed a few percent of the total measured flux, for standard coma models. This is consistent with many other published data sets taken when the comet was near aphelion. Our data includes the first detailed time series multi-color measurements of a cometary nucleus, and significant color variations were seen on October 3, though not repeated on October 4. The average color indices across both nights are: (V-R)=0.39±0.06 and (B-V)=0.73±0.06 ( R¯=19.76±0.03). We analysed the R-filter time-series photometry using the method of Harris et al. [Harris, A.W., Young, J.W., Bowell, E., Martin, L.J., Millis, R.L., Poutanen, M., Scaltriti, F., Zappala, V., Schober, H.J., Debehogne, H., Zeigler, K.W., 1989. Icarus 77, 171-186] to constrain the rotation period of the comet's nucleus, and find that a period of ˜11.45 h will satisfy the data, however the errors bars are large. We have successfully linked our data with the September 2002 data from Fernández et al. [Fernández, Y.R., Lowry, S.C., Weissman, P.R., Mueller, B.E.A., Samarasinha

  7. Leslie Peltier, Amateur Astronomer and Observer Extraordinaire

    NASA Astrophysics Data System (ADS)

    Corbin, B. G.

    2003-12-01

    surroundings. Peltier was a shy person who rarely left Delphos, and worked as a designer of children's furniture and toys until his death. However, he was widely recognized during his lifetime with articles about him appearing in popular magazines such as Reader's Digest and Newsweek. Many famous astronomers visited him at Delphos including W.W. Morgan, W.A. Hiltner, Donald Menzel, the Boks, and others. He received many honors including an honorary Doctor of Science degree from Bowling Green State University (Ohio) and the AAVSO's first Merit Award in 1934. Starlight Nights returned to print in 1999 with a foreword by David Levy, and is now introducing a new generation to the beauty and thrill of observing.

  8. Water vapor toward starless cores: The Herschel view

    NASA Astrophysics Data System (ADS)

    Caselli, P.; Keto, E.; Pagani, L.; Aikawa, Y.; Yıldız, U. A.; van der Tak, F. F. S.; Tafalla, M.; Bergin, E. A.; Nisini, B.; Codella, C.; van Dishoeck, E. F.; Bachiller, R.; Baudry, A.; Benedettini, M.; Benz, A. O.; Bjerkeli, P.; Blake, G. A.; Bontemps, S.; Braine, J.; Bruderer, S.; Cernicharo, J.; Daniel, F.; di Giorgio, A. M.; Dominik, C.; Doty, S. D.; Encrenaz, P.; Fich, M.; Fuente, A.; Gaier, T.; Giannini, T.; Goicoechea, J. R.; de Graauw, Th.; Helmich, F.; Herczeg, G. J.; Herpin, F.; Hogerheijde, M. R.; Jackson, B.; Jacq, T.; Javadi, H.; Johnstone, D.; Jørgensen, J. K.; Kester, D.; Kristensen, L. E.; Laauwen, W.; Larsson, B.; Lis, D.; Liseau, R.; Luinge, W.; Marseille, M.; McCoey, C.; Megej, A.; Melnick, G.; Neufeld, D.; Olberg, M.; Parise, B.; Pearson, J. C.; Plume, R.; Risacher, C.; Santiago-García, J.; Saraceno, P.; Shipman, R.; Siegel, P.; van Kempen, T. A.; Visser, R.; Wampfler, S. F.; Wyrowski, F.

    2010-10-01

    Aims: Previous studies by the satellites SWAS and Odin provided stringent upper limits on the gas phase water abundance of dark clouds (x(H2O) < 7 × 10-9). We investigate the chemistry of water vapor in starless cores beyond the previous upper limits using the highly improved angular resolution and sensitivity of Herschel and measure the abundance of water vapor during evolutionary stages just preceding star formation. Methods: High spectral resolution observations of the fundamental ortho water (o-H2O) transition (557 GHz) were carried out with the Heterodyne Instrument for the Far Infrared onboard Herschel toward two starless cores: Barnard 68 (hereafter B68), a Bok globule, and LDN 1544 (L1544), a prestellar core embedded in the Taurus molecular cloud complex. Detailed radiative transfer and chemical codes were used to analyze the data. Results: The RMS in the brightness temperature measured for the B68 and L1544 spectra is 2.0 and 2.2 mK, respectively, in a velocity bin of 0.59 km s-1. The continuum level is 3.5 ± 0.2 mK in B68 and 11.4 ± 0.4 mK in L1544. No significant feature is detected in B68 and the 3σ upper limit is consistent with a column density of o-H2O N(o-H2O) < 2.5 × 1013 cm-2, or a fractional abundance x(o-H2O) < 1.3 × 10-9, more than an order of magnitude lower than the SWAS upper limit on this source. The L1544 spectrum shows an absorption feature at a 5σ level from which we obtain the first value of the o-H2O column density ever measured in dark clouds: N(o-H2O) = (8 ± 4) × 1012 cm-2. The corresponding fractional abundance is x(o-H2O) ≃ 5 × 10-9 at radii >7000 AU and ≃2 × 10-10 toward the center. The radiative transfer analysis shows that this is consistent with a x(o-H2O) profile peaking at ≃10-8, 0.1 pc away from the core center, where both freeze-out and photodissociation are negligible. Conclusions: Herschel has provided the first measurement of water vapor in dark regions. Column densities of o-H2O are low, but prestellar

  9. SHRIMP U-Pb in zircon geochronology of granitoids from Myanmar: temporal constraints on the tectonic evolution of Southeast Asia

    NASA Astrophysics Data System (ADS)

    Barley, M. E.; Zaw, Khin

    2009-04-01

    southern Myanmar (Shan-Thai terrane) have magmatic ages of 82  1.4 Ma (Kawthoung), 62  1.2 Ma (Hermyngi) and 50  0.5 Ma (Auk Bok). Xenocryst zircons in these granitoids are either Proterozoic or derived from older members of the suite. This suite which extends into adjacent peninsular Thailand and was emplaced into thickened continental crust well inboard of the subduction zone during rapid convergence and subduction of the India-Australia plate. The primitive I-type Shangalon granodiorite in the Wuntho Batholith of west Myanmar has a magmatic age of 38.5  0.6 Ma indicating subduction continued until ~40 Ma. Metamorphic overgrowths to zircons in the MMB orthogneiss near Mandalay date a period of Eocene (~43 Ma) high-grade metamorphism possibly during crustal thickening related to the initial collision between India and Eurasia (65 to 55 Ma). This was followed by emplacement of syn-tectonic hornblende syenites and leucogranites between 35 and 23 Ma. Comparison of the geochronology of Myanmar granitoids with the Hymalayas, Tibet and other parts of Southeast Asia indicates that Myanmar played a key role linking the Hymalayan Orogen to the tectonic evolution of Southeast Asia.

  10. A Study of Structure in M33 Using Adaptive Optics

    NASA Astrophysics Data System (ADS)

    Wittman, David Michael

    1997-08-01

    FASTTRAC (Fast Adaptive Secondary for Tip-Tilt Removal by Automatic Centroiding) is a tip-tilt secondary system which increases the angular resolution of images taken at Steward Observatory's 90' Bok and 61' Bigelow telescopes. K band imagery is gathered with the facility infrared camera and wavefront sensing is done with a small format charge-coupled device (CCD). I examine desirable characteristics of wavefront-sensing CCDs and evaluate the performance of the device used in FASTTRAC according to those criteria. The main drawback of the device is its low quantum efficiency due to frontside illumination. The read noise of the system is adequate, particularly for FASTTRAC which is generally assigned to bright time. The increased angular resolution provided by FASTTRAC is desirable for imaging crowded fields, such as those found in Local Group galaxies. Stellar photometry is a more powerful tool for studying the structure of these galaxies than is surface photometry, in which the light from all types of stars is mixed together. In particular, the distribution of old stars is representative of the underlying mass distribution, so these stars may be used to measure the overdensity in the arms of spiral galaxies. FASTTRAC was used to observe fields in M33, the nearest spiral which is not seen edge-on. These fields were observed in a range of seeing conditions and with guide stars of varying magnitudes and positions relative to the fields of interest. I analyze the performance of FASTTRAC in these varying conditions and offer some advice to future FASTTRAC observers. I also analyze the crowding in the M33 fields and conclude that, to K~16.5, it does not vary significantly with placement in or outside of a spiral arm. Therefore a coarsely-sampled, wide field survey of the populations of M33 will not be systematically biased by crowding. Therefore a survey covering 35' by 25' was conducted in I and K bands, covering all of M33 out to a deprojected radius of 16 prime. The

  11. Thackeray's Globules in IC 2944

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Strangely glowing dark clouds float serenely in this remarkable and beautiful image taken with NASA's Hubble Space Telescope. These dense, opaque dust clouds - known as 'globules' - are silhouetted against nearby bright stars in the busy star-forming region, IC 2944. These globules were first found in IC 2944 by astronomer A.D. Thackeray in 1950. Although globules like these have been known since Dutch-American astronomer Bart Bok first drew attention to such objects in 1947, little is still known about their origin and nature, except that they are generally associated with areas of star formation, called 'HII regions' due to the presence of hydrogen gas. The largest of the globules in this image is actually two separate clouds that gently overlap along our line of sight. Each cloud is nearly 1.4 light-years (50 arcseconds) along its longest dimension, and collectively, they contain enough material to equal over 15 solar masses. IC 2944, the surrounding HII region, is filled with gas and dust that is illuminated and heated by a loose cluster of O-type stars. These stars are much hotter and much more massive than our Sun. IC 2944 is relatively close by, located only 5900 light-years (1800 parsecs) away in the constellation Centaurus. Thanks to the remarkable resolution offered by the Hubble Space Telescope, astronomers can for the first time study the intricate structure of these globules. The globules appear to be heavily fractured, as if major forces were tearing them apart. When radio astronomers observed the faint hiss of molecules within the globules, they realized that the globules are actually in constant, churning motion, moving supersonically among each other. This may be caused by the powerful ultraviolet radiation from the luminous, massive stars, which also heat up the gas in the HII region, causing it to expand and stream against the globules, leading to their destruction. Despite their serene appearance, the globules may actually be likened to clumps

  12. Spectrum from Embedded Star in Herbig-Haro 46/47

    NASA Technical Reports Server (NTRS)

    2003-01-01

    NASA's Spitzer Space Telescope has lifted the cosmic veil to see an otherwise hidden newborn star, while detecting the presence of water and carbon dioxide ices, as well as organic molecules. Using near-infrared light, Spitzer pierces through an optically dark cloud to detect the embedded outflow in an object called HH 46/47. Herbig-Haro (HH) objects are bright, nebulous regions of gas and dust that are usually buried within dark dust clouds. They are formed when supersonic gas ejected from a forming protostar, or embryonic star, interacts with the surrounding interstellar medium. These young stars are often detected only in the infrared.

    HH 46/47 is a striking example of a low mass protostar ejecting a jet and creating a bipolar, or two-sided, outflow. The central protostar lies inside a dark cloud (known as a 'Bok globule') which is illuminated by the nearby Gum Nebula. Located at a distance of 1140 light-years and found in the constellation Vela, the protostar is hidden from view in the visible-light image (inset). With Spitzer, the star and its dazzling jets of molecular gas appear with clarity.

    The Spitzer image (inset) was obtained with the infrared array camera and is a three-color mosaic. Emission at 3.6 microns is shown as blue, emission from 4.5 and 5.8 microns has been combined as green, and 8.0 micron emission is depicted as red. The 8-micron channel of the camera is sensitive to emission from polycyclic aromatic hydrocarbons. These organic molecules, comprised of carbon and hydrogen, are excited by the surrounding radiation field and become luminescent, accounting for the reddish cloud. Note that the boundary layer of the 8-micron mission corresponds to the lower right edge of the dark cloud in the visible-light picture.

    The primary image shows a spectrum obtained with Spitzer's infrared spectrograph instrument, stretching from wavelengths of 5.5 microns (left) to 20 microns (right). Spectra are graphical representations of a celestial

  13. Obituary: Frank K. Edmondson (1912-2008)

    NASA Astrophysics Data System (ADS)

    Pilachowski, Catherine A.; Olson, Margaret K. Edmondson; Edmondson, Frank K., Jr.

    2009-12-01

    Pluto's status to a dwarf planet. While in Flagstaff, Frank met Margaret Russell, the youngest daughter of famed American astronomer Henry Norris Russell of Princeton University. The young couple instantly bonded and became engaged after only two weeks. He and Margaret were married on November 24, 1934. Frank and Margaret remained inseparable until her death in 1999, always together at meetings of the American Astronomical Society, the International Astronomical Union, and elsewhere. Studying under astronomer Bart Bok, Frank received his Ph.D. in astronomy in 1937 from Harvard University, where he completed his dissertation on "The Absorption of Light in the Galaxy," and joined the faculty as an Instructor in Astronomy at Indiana University. Frank became the second member of the Astronomy Department, with Professor W. A. Cogshall, housed in Kirkwood Observatory. Frank served as chair of the department from 1944 until 1978. Under his leadership, the University acquired the Goethe Link Observatory in Brooklyn, IN, (a gift from Dr. Goethe Link, a noted Indianapolis physician and avid amateur astronomer), established a graduate program in astronomy, and enlarged the Department of Astronomy from two faculty members to eight. In one of his favorite stories, Edmondson bet Professor Cogshall a chocolate ice cream cone that President Herman B Wells would fund a new position for the Department, knowing full well that Wells had already agreed. Frank retired from IU in 1983. Studying under astronomer Bart Bok, Frank received his Ph.D. in astronomy in 1937 from Harvard University, where he completed his dissertation on "The Absorption of Light in the Galaxy," and joined the faculty as an Instructor in Astronomy at Indiana University. Frank became the second member of the Astronomy Department, with Professor W. A. Cogshall, housed in Kirkwood Observatory. Frank served as chair of the department from 1944 until 1978. Under his leadership, the University acquired the Goethe Link

  14. Obituary: Allan R. Sandage (1926-2010)

    NASA Astrophysics Data System (ADS)

    Devorkin, David

    2011-12-01

    Weart on 22 May 1978, Niels Bohr Library & Archives, American Institute of Physics, College Park, MD, USA, www.aip.org/history/ohilist/ and http://www.aip.org/history/ohilist/4380_1.html] Allan enrolled in Miami University in 1943 because his father was on the faculty there at the time. He majored in physics until he entered the Navy for 18 months to train as an electronics technician's mate. His training began in Chicago, where he became acquainted with others interested in astronomy, like Arthur Code and Albert Wilson, and then his tour took him to Gulfport, Mississippi, and finally to Treasure Island in the San Francisco Bay. When Sandage was discharged from the Navy his father was moving to the University of Illinois, so Allan transferred there, entering a much larger and more competitive physics department. He majored in physics and mathematics but he also minored in philosophy, and took a celestial mechanics course from Robert H. Baker. He volunteered to work at the observatory, learning the art and craft of calibrating photographic plates so that magnitudes could be transferred and intercompared from plate to plate, an experience that he later realized prepared him well for his life career and also introduced him into Bart Bok's "star counting" circuit based at Harvard. In consequence, when Bok visited Illinois sometime in 1947, he invited Sandage to work at Harvard in their summer school at the Agassiz Station mapping Milky Way fields. Sandage applied both to Harvard and Caltech for graduate school. Harvard was very well established in its graduate program whereas Caltech was just beginning to offer the Ph.D. in astronomy. He chose Caltech because that was where the big telescopes were. His family had visited Mount Wilson in 1941 during a summer when his father was teaching at Berkeley, and since that time Sandage had dreamed of observing with those giant telescopes. Thus in September 1948, Sandage joined the first class of students to engage in formal graduate

  15. Obituary: E. Dorrit Hoffleit, 1907-2007

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia

    2007-12-01

    next year as a research assistant (later research associate) at Harvard College Observatory, then directed by Harlow Shapley, about whom her opinion was much warmer than that expressed by Cecilia Payne Gaposchkin. Dorrit's immediate supervisor at Harvard was Henrietta Swope, daughter of the President of General Electric, and eventually best known for work at Mount Wilson Observatory with Walter Baade on variable stars in the Magellanic Clouds, published in papers that continued to appear long after Baade's death. Hoffleit's first ten papers were also on variable stars and appeared in Harvard Observatory publications. But the MA she completed in 1932 was on the light curves of meteors and was published in the Proceedings of the United States National Academy of Sciences. By this time, Dorrit had established a work pattern that was to persist right up to retirement - at least 40 hours per week on whatever the current boss thought she should be doing, and another 20 or so on other astronomical research that interested her. Hffleit had supposed that an MA would be her highest degree, but Shapley urged her to go on for a PhD, with, it would seem, a bit of urging on both sides from Bart Bok, who informed her that "if God recommends that you do something, it is your duty to do it." The thesis (PhD 1938) was on yet a third topic, spectroscopic parallaxes. This means determining the luminosities of stars, hence their distances, from line width and ratio diagnostics in their spectra. The pioneer was Antonia Maury, whose insights were not appreciated by Shapley's predecessor, E. C. Pickering. Another valuable Hoffleit mentor was Ernst Öpik, on a three-month visit to Harvard in 1934, from whom Dorrit learned stellar statistics and half a dozen other things. The thesis also provided her "break out" paper into the Astrophysical Journal (on CN as a giant/dwarf discriminator). Hoffleit began to branch out into astrometry, comets, and other parts of astronomy and, starting in 1941

  16. Obituary: Donald Alexander Macrae, 1916-2006

    NASA Astrophysics Data System (ADS)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  17. Obituary: Donald Alexander Macrae, 1916-2006

    NASA Astrophysics Data System (ADS)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  18. Obituary: E. Dorrit Hoffleit, 1907-2007

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia

    2007-12-01

    next year as a research assistant (later research associate) at Harvard College Observatory, then directed by Harlow Shapley, about whom her opinion was much warmer than that expressed by Cecilia Payne Gaposchkin. Dorrit's immediate supervisor at Harvard was Henrietta Swope, daughter of the President of General Electric, and eventually best known for work at Mount Wilson Observatory with Walter Baade on variable stars in the Magellanic Clouds, published in papers that continued to appear long after Baade's death. Hoffleit's first ten papers were also on variable stars and appeared in Harvard Observatory publications. But the MA she completed in 1932 was on the light curves of meteors and was published in the Proceedings of the United States National Academy of Sciences. By this time, Dorrit had established a work pattern that was to persist right up to retirement - at least 40 hours per week on whatever the current boss thought she should be doing, and another 20 or so on other astronomical research that interested her. Hffleit had supposed that an MA would be her highest degree, but Shapley urged her to go on for a PhD, with, it would seem, a bit of urging on both sides from Bart Bok, who informed her that "if God recommends that you do something, it is your duty to do it." The thesis (PhD 1938) was on yet a third topic, spectroscopic parallaxes. This means determining the luminosities of stars, hence their distances, from line width and ratio diagnostics in their spectra. The pioneer was Antonia Maury, whose insights were not appreciated by Shapley's predecessor, E. C. Pickering. Another valuable Hoffleit mentor was Ernst Öpik, on a three-month visit to Harvard in 1934, from whom Dorrit learned stellar statistics and half a dozen other things. The thesis also provided her "break out" paper into the Astrophysical Journal (on CN as a giant/dwarf discriminator). Hoffleit began to branch out into astrometry, comets, and other parts of astronomy and, starting in 1941