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Sample records for brazoria county tx

  1. 75 FR 9635 - Cancellation of Environmental Impact Statement; Harris and Brazoria Counties, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Highway Administration Cancellation of Environmental Impact Statement; Harris and Brazoria... between Bellfort Road and FM 1462 in Harris and Brazoria Counties, Texas. The use of Federal funding...

  2. Influence of Changing Hydrology on Pedogenic Calcite Precipitation in Vertisols, Dance Bayou, Brazoria County, Tx: Implications for Estimating Paleoatmospheric PCO2

    NASA Astrophysics Data System (ADS)

    Mintz, J. S.; Driese, S. G.; Ludvigson, G. A.; Breecker, D. O.

    2010-12-01

    Pedogenic (soil formed) calcites preserved in the sedimentary record enable estimation of paleoatmospheric pCO2 using the calcite paleobarometer. A fundamental assumption for applying this paleobarometer is that the calcite precipitated while the soil was in communication with the atmosphere so that atmospheric CO2 concentrations had a direct influence on the calcite δ13C value. Here we address the timing of calcite precipitation in relation to the soil saturation state and atmosphere connectivity in a modern Vertisol (smectitic, clay-rich soil, seasonally saturated) in Brazoria County, Texas. Luminescent phases of calcite growth have more negative δ13C values (avg. δ13C = -11.1 ‰ PDB) than the non-luminescent phases (avg. δ13C = -2.8 ‰ PDB). The luminescent phase formed during the water-saturated portion of the year limiting the soil connectivity with the atmosphere, minimizing the incorporation of atmospheric CO2 and negating its use for pCO2 estimations. The non-luminescent phase formed during the well-drained portion of the year when atmospheric CO2 mixed with soil-respired CO2 and is therefore useful for pCO2 estimation. From these results we present a model to independently test the saturation state of a paleosol at the time of pedogenic carbonate precipitation. Finally we calculate soil respiration rates that are an order of magnitude lower than those that are typically assumed in the paleobarometer equation. Many of the pCO2 estimates through the Phanerozoic are based on carbonate in paleo-Vertisols and may therefore be overestimated or potentially invalid. A) Comparisons of typical morphotype isotope values with interpreted soil conditions at the time of calcite precipitation. B) Model of carbonate precipitation of non-luminescent calcite nodules (dark circles) in the well-drained portion of the season (top) and luminescent calcite nodules (light circles) in the saturated portion of the season (bottom), in a Vertisol at Dance Bayou, Brazoria Co

  3. DRAFT LANDSAT DATA MOSAIC: MONTGOMERY COUNTY, TEXAS; HARRIS COUNTY, TEXAS; FORT BEND COUNTY, TEXAS; BRAZORIA COUNTY, TEXAS; GALVESTON COUNTY, TEXAS

    EPA Science Inventory

    This is a draft Landsat Data Mosaic, which contains remote sensing information for Montgomery County, Texas Harris County, Texas Fort Bend County, Texas Brazoria County, Texas Galveston County, and Texas Imagery dates on the following dates: October 6, 1999 and September 29, 200...

  4. Feldspar diagenesis in the Frio Formation, Brazoria County, Texas Gulf Coast

    NASA Astrophysics Data System (ADS)

    Land, Lynton S.; Milliken, Kitty L.

    1981-07-01

    Tremendous quantities of detrital feldspar have been dissolved or albitized below about 14,000 ft (4,267 m) in the Frio Formation (Oligocene), Chocolate Bayou Field, Brazoria County, Texas. Some sandstones no longer contain any unmodified detrital feldspar grains. Material transfer involved in these reactions is immense, affecting at least 15% of the rock volume. Thus, albitization has important implications for several other diagenetic processes that involve feldspars or their components. These processes include formation of secondary porosity, precipitation of quartz and carbonate cements, and the evolution of Na-Ca-Cl formation water.

  5. Scanning electron microscope examination of shale in core from the Frio Formation, Brazoria County, Texas

    SciTech Connect

    Alley-McReynolds, P.D.

    1994-09-01

    Scanning electron microscope (SEM) examination of additional core from shallower geopressured and nongeopressured Frio Formation wells in Brazoria County shows similar fracture patterns and clay textures to those reported earlier in the Skrabanek 1 well. The additional wells examined by SEM are 1-B Minnie Mettler, 2847 to 3254 m; Pleasant Bayou 1, 3532 to 4750 m; and Phillips Petroleum JJ 1, 4919 to 5128 m. We noted that shales occurring from 2744 to 5488 in have similar grain orientation and fracture patterns. Pleasant Bayou 1 is strikingly similar to Skrabanek 1, having coarse flakes and grains of quartz and feldspar disbursed throughout. Phillips Petroleum JJ 1 is more uniform in appearance, lacking distinct clay flakes and scattered grains. 1-B Minnie Mettler is similar in appearance to Phillips Petroleum JJ 1, having a uniform distribution of components; however, the clay flakes are less densely packed. Fractures are present in all three wells. The abundance of both horizontal and vertical fractures at varying depths could act as avenues of fluid flow within geopressured shales.

  6. Predicting diagenetic history and reservoir quality in the Frio Formation of Brazoria County, Texas and Pleasant Bayou test wells

    SciTech Connect

    Kaiser, W.R.; Richmann, D.L.

    1981-01-01

    Good-quality geothermal reservoirs displaying secondary porosity exist on the upper Texas coast (Brazoria County), site of the Pleasant Bayou No. 1 and No. 2 wells, and are attributed to a moderately stable mineral assemblage, normal geothermal gradients, and low in situ pH. Major authigenic minerals are calcite, quartz, and kaolinite. Detrital feldspar has been extensively albitized at depth. Major diagenetic events overlapped, occurring in the general order-precipitation of calcite, formation of quartz overgrowths, albitization, leaching of calcite to form secondary porosity, and precipitation of kaolinite. Seventeen Brazoria County water analyses including two from the Pleasant Bayou No. 2 well were thermodynamically tested. Predictions based on equilibrium thermodynamics add new insight on mineral stabilities and are consistent with the paragenetic sequence developed from petrographic data. Early precipitation of calcite at shallow depths of burial is predicted. Low temperture and low in situ pH explain the general absence of chlorite. The use of solution-mineral equilibria as a predictor of reservoir quality is inconclusive, but well-defined clustering of waters indicates that identification of regional trends will probably be possible. Shallow waters may be the key to predicting reservoir quality at depth.

  7. 76 FR 28060 - Regional Habitat Conservation Plan, Hays County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Fish and Wildlife Service Regional Habitat Conservation Plan, Hays County, TX AGENCY: Fish and Wildlife... statement, final Hays County regional habitat conservation plan, and draft record of decision. SUMMARY: We... (EIS), the final Hays County regional habitat conservation plan (RHCP) under the National...

  8. 76 FR 76298 - Drawbridge Operation Regulation; Old Brazos River, Freeport, Brazoria County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... operation of the Union Pacific Railroad Swing Span Bridge across the Old Brazos River, mile 4.4, at Freeport... feet above mean sea level (MSL). This deviation will allow the lift span of the bridge to remain in the... (7a-09-8) dated September 14, 2010. The project involves the replacement of the old swing span...

  9. 76 FR 4818 - Drawbridge Operation Regulation; Old Brazos River, Freeport, Brazoria County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... operation of the Union Pacific Railroad Swing Span Bridge across the Old Brazos River, mile 4.4, at Freeport... February 10, 2011 until 7 a.m. on February 16, 2011. This deviation will allow the swing span of the bridge to remain in the closed-to-navigation position in order for the north end of the swing span to be...

  10. 76 FR 61135 - Environmental Impact Statement: El Paso County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... Federal Highway Administration Environmental Impact Statement: El Paso County, TX AGENCY: Federal Highway... proposed ] improvements to Loop 375 Border Highway West, in El Paso County, Texas, is being rescinded. FOR... Loop 375 C sar Ch vez Highway (Border Highway West Extension) in El Paso, Texas, to include the...

  11. 75 FR 67806 - Environmental Impact Statement; Nueces County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... Federal Highway Administration Environmental Impact Statement; Nueces County, TX AGENCY: Federal Highway... proposed improvements to United States Highway 181/State Highway 286 (Crosstown Expressway), in Nueces... Nueces County, Texas. The project limits were defined as the limits of the schematic design. The...

  12. Environmental assessment of the brine pipeline replacement for the Strategic Petroleum Reserve Bryan Mound Facility in Brazoria County, Texas

    SciTech Connect

    Not Available

    1993-09-01

    The Department of Energy (DOE) has prepared an environmental assessment (EA), DOE/EA-0804, for the proposed replacement of a deteriorated brine disposal pipeline from the Strategic Petroleum Reserve (SPR) Bryan Mound storage facility in Brazoria County, Texas, into the Gulf of Mexico. In addition, the ocean discharge outfall would be moved shoreward by locating the brine diffuser at the end of the pipeline 3.5 miles offshore at a minimum depth of 30 feet. The action would occur in a floodplain and wetlands; therefore, a floodplain/wetlands assessment has been prepared in conjunction with this EA. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969 (42 USC. 4321, et seg.). Therefore, the preparation of an Environmental Impact Statement (EIS) is not required, and the Department is issuing this Finding of No Significant Impact (FONSI). This FONSI also includes a Floodplain Statement of Findings in accordance with 10 CFR Part 1022.

  13. 75 FR 70945 - Caddo National Wildlife Refuge, Harrison County, TX; Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... Fish and Wildlife Service Caddo National Wildlife Refuge, Harrison County, TX; Comprehensive... Wildlife Refuge, Harrison County, TX. We provide this notice in compliance with our CCP policy to advise... Lake NWR (Refuge), located in Harrison County, TX. This notice complies with our CCP policy to...

  14. 75 FR 31463 - Comal County Regional Habitat Conservation Plan, Comal County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ... Fish and Wildlife Service Comal County Regional Habitat Conservation Plan, Comal County, TX AGENCY... statement, draft habitat conservation plan, and permit application; announcement of a public hearing... County has completed a draft Habitat Conservation Plan (dHCP) as part of the application package. We...

  15. Cultural resources survey and assessment of the proposed Department of Energy Freeport to Texas City pipeline, Brazoria and Galveston Counties, Texas. Final report

    SciTech Connect

    Castille, G.J.; Whelan, J.P. Jr.

    1986-01-01

    An intensive survey and testing program of selected segments of a proposed Department of Energy pipeline were conducted by Coastal Environments, Inc., Baton Rouge, Louisiana, during December 1985 and January 1986. The proposed pipeline runs from Texas City, Galveston County to Bryan Mound, Brazoria County. The pedestrian survey was preceded by historical records survey to locate possible historic sites within the DOE righ-of-way. Four prehistoric sites within the ROW (41BO159, 160, 161, 162) and one outside the ROW (41BO163) were located. All are Rangia cuneata middens. The survey results are discussed with particular reference to the environmental settings of the sites and the effectiveness of the survey procedure. Two of the sites located within the ROW were subjected to additional testing. The results of the backhoe testing program are included in the site descriptions, and the scientific value of the sites are presented. 52 refs., 20 figs., 10 tabs.

  16. 75 FR 45557 - Prevailing Rate Systems; Definition of Tulsa County, OK, and Angelina County, TX, to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ...; ] OFFICE OF PERSONNEL MANAGEMENT 5 CFR Part 532 RIN 3206-AM22 Prevailing Rate Systems; Definition of Tulsa County, OK, and Angelina County, TX, to Nonappropriated Fund Federal Wage System Wage Areas AGENCY... area of application to the Oklahoma, OK, nonappropriated fund (NAF) Federal Wage System (FWS) wage...

  17. 77 FR 40897 - Notice of Intent to Repatriate Cultural Items: Gregg County Historical Museum, Longview, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... burials at the E. Fields site (no site trinomial has been assigned), in Harrison County, TX. The exact... funerary objects were removed from the HC site (no site trinomial has been assigned), in Harrison County... assigned), in Harrison County, TX. The exact location of this site is not specified in notes or records...

  18. Hydrologic, water-quality, and sediment-quality data for the Christmas Bay system, Brazoria County, Texas, February 1999-March 2000

    USGS Publications Warehouse

    East, Jeffery W.

    2002-01-01

    The Christmas Bay system is a group of three small secondary bays (Christmas, Bastrop, and Drum Bays) at the southwestern end of the Galveston Bay estuarine system in Brazoria County, Texas. During February 1999-March 2000, hydrologic, water-quality, and sediment-quality data were collected from each of the three bays to establish baseline conditions. Gage-height fluctuations closely matched open-water tidal fluctuations. Rainfall during February 1999-February 2000 was about 20 percent below the annual average. Specific conductance, pH, water temperature, and dissolved oxygen monitored at 30-minute intervals in Christmas Bay for 13 months showed seasonal variations typical of monitoring stations on the Texas Gulf Coast. Prevailing winds were from the southeast. Monthly water-quality sampling for 13 months showed that in each of the three bays concentrations of major ions were small, and most nutrient concentrations were at or less than minimum reporting levels; indicator bacteria counts were consistently higher in samples collected from Drum Bay. Several trace elements (sampled twice) were detected in small concentrations. The only organochlorine pesticides (sampled once) that were greater than minimum reporting levels were atrazine, deethylatrazine, metolachlor, and simazine. During February 29-March 29, 2000, three semipermeable membrane devices were deployed at the Christmas Bay monitoring station. Seven of 77 semivolatile organic compounds analyzed in the lipids from the devices were detected in minute amounts. Analyses of surficial bed sediment sampled once in each of the three bays yielded detections of a number of semivolatile organic compounds; all concentrations were less than 10 micrograms per liter and much less than the respective benchmark concentration for those compounds that have had a benchmark concentration established for the protection of aquatic life.

  19. 75 FR 8994 - Certification of the Attorney General; Williamson County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... Certification of the Attorney General; Williamson County, TX In accordance with Section 8 of the Voting Rights... of the Attorney General and the Director of the Census made under Section 4(b) of the Voting Rights...). Dated: February 23, 2010. Eric H. Holder Jr., Attorney General of the United States. BILLING CODE...

  20. 77 FR 18853 - Trinity River National Wildlife Refuge, Liberty County, TX; Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... Fish and Wildlife Service Trinity River National Wildlife Refuge, Liberty County, TX; Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability; request for comments. SUMMARY: We, the U.S. Fish and Wildlife Service (Service), announce...

  1. 76 FR 5196 - Aransas National Wildlife Refuge Complex, Aransas, Calhoun, and Refugio Counties, TX; Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Counties, TX; Final Comprehensive Conservation Plan and Finding of No Significant Impact for Environmental... plan (CCP) and finding of no significant impact (FONSI) for the environmental assessment (EA) for the... business hours at 500 Gold Avenue SW., Albuquerque, NM 87102. FOR FURTHER INFORMATION CONTACT: Dan...

  2. 75 FR 63533 - Environmental Impact Statement: Cameron County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... proposed improvements to United States Highway 181/State Highway 286 (Crosstown Expressway), in Nueces... Nueces County, Texas. The project limits were defined as the limits of the schematic design. The project... the Corpus Christi Ship Channel but south of the Nueces Bay Causeway; the southern limit was the...

  3. 75 FR 18941 - Environmental Impact Statement: Bexar County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... proposed improvements to Loop 1604 in San Antonio, Texas, within Bexar County limits to enhance mobility... changes to the aforementioned EIS for proposed Loop 1604 improvements. Specifically, the southwestern..., advising the public that they would be preparing an EIS for transportation improvements to Loop 1604...

  4. 76 FR 9640 - Prevailing Rate Systems: Santa Clara, CA, Tulsa County, OK, and Angelina County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... MANAGEMENT 5 CFR Part 532 RIN 3206-AM22 Prevailing Rate Systems: Santa Clara, CA, Tulsa County, OK, and... Schedule of Nonappropriated Fund Regular Wage Schedules by removing, under the State of California, ``Santa..., ``Santa Clara,'' which was abolished as a NAF FWS wage area by a final rule (74 FR 9951) published...

  5. The relationship between seismicity and wastewater injection in Johnson County, TX

    NASA Astrophysics Data System (ADS)

    Lee, S. S.; Walter, J. I.; Frohlich, C.; DeShon, H. R.

    2015-12-01

    In light of recent research that suggests some high-rate wastewater injection wells from commercial oil and gas operations are casually linked to recent earthquakes in North Texas and Oklahoma, we apply a waveform cross-correlation technique to continuous waveform data from 38 seismic stations across Texas and Oklahoma using templates from 96 cataloged events from 2010-2015. We focus on an area near Venus TX, 40 km south of the Dallas-Fort Worth metropolitan area in Johnson County where a M4.0 earthquake was reported by the USGS on 7 May 2015. The epicenter was within several km of 4 high rate wells with max injection rates ranging between 684,000-833,000 barrels/month. Templates were chosen from the USGS and locally derived Venus aftershock sequence, events in the ANSS catalog with a minimum magnitude of 2 between 2009-2015, and previously located earthquakes recorded by USArray stations between 2009-2011. In Johnson County, there are 27 wastewater injection wells, each with a reported maximum injection rate of 104,000 barrels/month and greater. We detected 494 events within Johnson and adjacent counties, with approximately 36% of the detections occurring within 10 km of the Venus earthquake, spanning March 2010 to June 2015. Most of the seismicity occurs adjacent to higher rate injection wells, suggesting a link between monthly injection rate and earthquake occurrence. Template matching allows us to detect earthquakes otherwise too small to be picked up by routine earthquake identification methods and informs our research concerning the presence and spatial distribution of possibly induced, small magnitude earthquakes. We plan to apply this technique to detect seismicity that may have occurred prior to the start of wastewater injection or felt earthquakes.

  6. Groundwater withdrawals 1976, 1990, and 2000--10 and land-surface-elevation changes 2000--10 in Harris, Galveston, Fort Bend, Montgomery, and Brazoria Counties, Texas

    USGS Publications Warehouse

    Kasmarek, Mark C.; Johnson, Michaela R.

    2013-01-01

    Measured land-surface-elevation changes from December 31, 2000, to December 31, 2010, ranged from an elevation increase of 0.06 feet (ft), or an average increase in elevation of 0.006 ft per year, at the Seabrook borehole extensometer located near Seabrook, Tex., to an elevation decrease of 1.28 ft, or an average decrease in elevation of 0.128 ft per year, at a PAM station north of Jersey Village, Tex. (PAM 07). Measured land-surface-elevation changes from December 31, 2005, to December 31, 2010, ranged from an elevation increase of 0.07 ft, or an average increase in elevation of 0.014 ft per year, at PAM 09 in far northeastern Harris County to an elevation decrease of 0.51 ft, or an average decrease in elevation of 0.102 ft per year, at PAM 07.

  7. 76 FR 68188 - Valero Refining-Texas, L.P. v. Port of Corpus Christi Authority of Nueces County, TX; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... of Corpus Christi Authority of Nueces County, TX; Notice of Filing of Complaint and Assignment Notice... Refining-Texas, L.P., hereinafter ``Complainant,'' against the Port of Corpus Christi Authority of...

  8. 76 FR 70365 - Prevailing Rate Systems; Redefinition of the Austin, TX and Waco, TX, Appropriated Fund Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Area Brazos, Burleson, and Robertson Counties, TX, comprise the College Station-Bryan, TX MSA. The College Station-Bryan MSA is split between the Austin, TX, and Waco, TX, wage areas. Burleson County is... Brazos County, the core county in the College Station-Bryan MSA, we recommend that the entire...

  9. 77 FR 40406 - Cancellation of Supplemental Environmental Impact Statement (SEIS); Travis County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... Highway (SH) 71 West through Oak Hill, in Travis County, Texas, is being rescinded. FOR FURTHER... of US 290/SH 71 West through Oak Hill, in Travis County, Texas. The improvements proposed between... the NOI to prepare a SEIS for US 290/SH 71 West through Oak Hill from RM 1826 to Joe Tanner Lane....

  10. 75 FR 54420 - Cancellation of Supplemental Environmental Impact Statement (SEIS); Travis County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... Statement (SEIS) would be prepared for the proposed SH 71 roadway between Riverside Drive and SH 130 in... for proposed improvements to State Highway (SH) 71 from Riverside Drive to SH 130, in Travis County... to 40 CFR 1508.22 and 43 TAC Sec. 2.5(e)(2) for proposed improvement of SH 71 from Riverside Drive...

  11. Comparative palynology of clastics and lignites from the Manning Formation, Jackson Group, Upper Eocene, Grimes County, TX

    SciTech Connect

    Gennett, J.A.

    1996-09-01

    The 3500 lignite seam at the Gibbons Creek Mine in Grimes County, TX was sampled for pollen and spores at 10 cm intervals. The majority of samples are dominated (to 60%) by Momipites from the Juglandaceae (walnut family), as is typical of Jackson Group sediments. Other palynomorph taxa vary systematically, with a peak of pollen of the freshwater tree Nyssa (blackgum) and associated Rboipites angustus (to 17%) occurring at the base. Higher in the seam, increase (to 55%) of Cupuliferoipollenites (a chestnut-like grain) and Cyrillaceae-pollenites? ventosus (to 7%) percentages may indicate a higher salinity environment. A Chrysophyllum (satin leaf) peak (to 25%) near the top of the seam suggests relatively shallow fresh-water conditions. Core samples from an interval above the lignites represent a transgressive-regressive cycle in inner shelf clastics. These samples were taken at 40 cm or greater intervals and reveal the regional pollen flora. Although minor changes occur, palynomorph spectra are for the most part homogenous. The dominant grain is again Momipites coryloides, but in general percentages are lower (to 35%). Cupuliferoipollenites (to 17%), Chrysophyllum (to 5%), and Rhoipites angustus (to 3%) are not less important, but do not peak as they do in the lignite spectra. Palm leaf megafossils; in one sample suggest a clastic wetland; in this sample palm pollen (mostly Arecipites, representing the modern saw palmetto) reaches 73%. Another sample contains high (26%) percentages of the fern spore Lygodiumsporites adriennis. High percentages of these two taxa do not occur in the lignite samples.

  12. Upper Strawn (Desmoinesian) carbonate and clastic depositional environments, SE King County, TX

    SciTech Connect

    Boring, T.H. )

    1990-05-01

    The Pennsylvanian upper Strawn Group of southeast King County, Texas, provides a unique setting to study interactions between coeval carbonate and clastic deposition during the Desmoinesian. One of the most perplexing problems is the relationship of massive Pennsylvanian platform carbonates to shallow-water marine and deltaic sediments. Within the study area carbonate facies were deposited along the northern edge of the Knox-Baylor trough on the Spur platform, and terrigenous clastics were carried toward the Midland basin through the Knox-Baylor trough. Based on the analysis of subsurface cores, five carbonate lithofacies and four clastic lithofacies were recognized in southeast King County, Texas. The distribution and geometry of these lithofacies are related to variations in the rate of subsidence in the Knox-Baylor trough, Pennsylvanian tectonics, deltaic progradation, avulsion and compaction. The platform carbonates within the northern region record environments within the carbonate platform complex, including middle platform, outer platform, algal mound, and platform margin. The quartzarenitic sandstones within the southern region occur in a variety of complex depositional geometries, including distributary bar fingers, lobate deltas, and offshore bars. The upper Strawn Group provides an attractive area for exploration geology. Both carbonates and clastics provide excellent reservoirs from a depth of approximately 5,000 to 6,000 ft. Total production since the early 1940s, within the area is over 100,000,000 bbl of oil. Multiple pay zones within a 600-ft interval also provide an added incentive for exploration. Areas within and around the Knox-Baylor trough deserve additional study due to these relatively shallow, unexplored, multiple pay zones.

  13. 77 FR 19521 - Prevailing Rate Systems; Redefinition of the Austin, TX and Waco, TX, Appropriated Fund Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... 3206-AM50 Prevailing Rate Systems; Redefinition of the Austin, TX and Waco, TX, Appropriated Fund... of the Austin, TX, and Waco, TX, appropriated fund Federal Wage System (FWS) wage areas. The final rule redefines Burleson and Lampasas Counties, TX, from the Austin wage area to the Waco wage...

  14. 75 FR 13669 - Amendment of Class E Airspace; Dumas, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Instrument Approach Procedures (SIAPs) at Moore County Airport, Dumas, TX, and updates the airport's... rulemaking to amend Class E airspace for Dumas, TX, reconfiguring controlled airspace at Moore County Airport... surface to accommodate SIAPs at Moore County Airport, Dumas, TX. This action also updates the...

  15. Air quality modeling for Houston-Galveston-Brazoria area.

    PubMed

    Aloyan, A E; Arutyunyan, V; Haymet, A D; He, J W; Kuznetsov, Y; Lubertino, G

    2003-06-01

    A coupled numerical model of the atmospheric thermo-hydrodynamics and pollutant photochemical transport is described. This model can be used to study the complex relationships between the chemical and thermo-hydrodynamic processes in the atmosphere of urban areas with an emphasis on photochemical ozone formation. Preliminary numerical results of ozone and other key chemical atmospheric pollutant concentrations and distribution across the Houston-Galveston-Brazoria area using virtual emission data from area and mobile sources are presented.

  16. Superfund Record of Decision (EPA Region 6): Texarkana Wood Preserving Company, Texarkana, Bowie County, TX. (First remedial action), September 1990

    SciTech Connect

    Not Available

    1990-09-25

    The 25-acre Texarkana Wood Preserving site is a former wood treating facility in Bowie County, Texas, within the Days Creek 100-year floodplain. Surrounding land use is industrial, residential, and agricultural. Since the early 1900s, several lumber-related businesses have operated at the site, with documented creosote-based wood treating operations starting in 1954. By 1971, Texarkana was also using creosote and pentachlorophenol for wood preserving. State investigations of the site between 1968 and 1984, showed Texarkana to be negligent or delinquent in fulfilling various permit requirements. The Record of Decision (ROD) addresses onsite contaminated soil near the processing ponds and contaminated ground water in a shallow aquifer. The primary contaminants of concern affecting the soil, sediment, sludge, and ground water are organics including dioxin, PAHs, pesticides, and phenols.

  17. 78 FR 46947 - Adequacy Status of the Houston-Galveston-Brazoria, Texas Reasonable Further Progress and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... Attainment Demonstration Implementation Plan for the 1997 8-Hour Ozone Standard; Motor Vehicle Emission Budgets for Transportation Conformity Purposes AGENCY: Environmental Protection Agency (EPA). ACTION... emissions budgets (MVEBs) in the Houston-Galveston-Brazoria, Texas (HGB) 1997 8-hour ozone...

  18. 78 FR 72140 - Texas Disaster # TX-00417

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Texas Disaster TX-00417 AGENCY: U.S. Small Business Administration ACTION: Notice SUMMARY: This is... adversely affected by the disaster: Primary Counties: Caldwell, Hays, Travis. Contiguous Counties:...

  19. 75 FR 43886 - Proposed Amendment of Class E Airspace; Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ..., Nueces County Airport, TX (Lat. 27 46'43'' N., long. 97 41'26'' W.) Corpus Christi VORTAC, TX (Lat. 27 54... within a 6.3-mile radius of Nueces County Airport, and within a 7.6-mile radius of Aransas County...

  20. Shallow groundwater monitoring at the SACROC oilfield, Scurry County, TX: good news for geologic storage of CO2 despite a complex hydrogeologic and geochemical setting (Invited)

    NASA Astrophysics Data System (ADS)

    Smyth, R. C.; Romanak, K.; Yang, C.; Hovorka, S.

    2009-12-01

    The SACROC water study is the first comprehensive research project with application to geologic storage (GS) of CO2 that focuses on collection and interpretation of field measurements of groundwater (water level and water chemistry data). CO2 has been injected for enhanced oil recovery at the SACROC oilfield in Scurry County, TX since 1972. Hence, we have a perfect natural laboratory and an analog for monitoring future commercial CO2 sequestration sites. Kinder Morgan currently operates the SACROC oilfield where over 150 million metric tons (MMT) of CO2 has been injected for EOR at ~2 km depth; over 75 MMT of the CO2 has been produced and re-injected. CO2 is assumed to be trapped in the deep subsurface at SACROC. The goals of monitoring shallow groundwater over CO2 injection sites are to (1) confirm that CO2 has remained in the deep subsurface and (2) assess impacts to water quality if CO2 were to migrate upward along conduit flow paths (e.g. leaking well bores). We collected groundwater and stratigraphic data within an ~3,000 km2 area centered on SACROC to establish regional variability prior to assessing potential impacts to groundwater from CO2 injection. Groundwater data include results from five sampling trips between June 2006 and November 2008, and a compilation of historical data from the Texas Water Development Board database, dating back to 1936. Sources of complexity that contribute to data interpretation challenges include: (1) regional historic oilfield activity, (2) multiple freshwater-bearing strata in the regional Dockum aquifer, (3) sampled wells screened in shallowest (30 m), deepest (150 m), or across both water-bearing zones, (4) variable discharge rate of sampled wells (<5 to >250 gpm), (5) groundwater flow divide that bisects SACROC, (6) variable aquifer recharge mechanisms, (7) temporal variability in groundwater levels and chemistry, (8) cation exchange, (9) presence of biogenically-produced CO2 in aquifer, and (10) incongruent dissolution

  1. 78 FR 48294 - Amendment of Class E Airspace; Mason, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Mason, TX AGENCY: Federal... Mason, TX. Additional controlled airspace is necessary to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures at Mason County Airport. This action enhances the safety...

  2. 75 FR 13453 - Proposed Amendment of Class E Airspace; Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ..., Nueces County Airport, TX (Lat. 27 46'43'' N., long. 97 41'26'' W.) Corpus Christi VORTAC, TX (Lat. 27 54...Campbell Airport, and within a 6.3-mile radius of Nueces County Airport, and within a 7.6-mile radius...

  3. 75 FR 8742 - Notice of Inventory Completion: Stephen F. Austin State University, Nacogdoches, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... individual were removed from an airport west of Tyler in Smith County, TX, by ``Red'' McFarland, a private... Kickapoo River, Smith County, TX, by ``Red'' McFarland, a private citizen. The human remains are located in... marine shell beads and fragments; 1 fragmented marine shell pendant; 3 deer teeth; 9 pigment samples;...

  4. 75 FR 58339 - Prevailing Rate Systems; Redefinition of the Shreveport, LA; Texarkana, TX; Milwaukee, WI; and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ..., TX, comprise the Longview, TX MSA. The Longview MSA is currently split between the Shreveport, LA... on an analysis of the regulatory criteria for Gregg County, the core county in the Longview MSA, we recommend that the entire Longview MSA be defined to the Shreveport area of application. The...

  5. Public health assessment for Odessa Superfund Site (a/k/a Sprague Road Groundwater Plume) Ector, Ector County, Texas, Region 6: CERCLIS number TX0001407444. Final report

    SciTech Connect

    1998-12-28

    The Sprague Road Groundwater Plume National Priorities List site, consists of three plumes of chromium contaminated water just outside the northern city limits of Odessa, Ector County, Texas. The chromium in the groundwater is a public health hazard to people who continue to use the chromium-contaminated water wells for drinking. Chromium in soil at Leigh Metal Plating Inc. presents a potential public health hazard. Although this facility is surrounded by a fence, access to the site is not entirely restricted. There is a five-foot pit on the National Chromium Corporation site that could present a physical hazard to children trespassing on the site.

  6. 78 FR 37793 - In the Matter of: Jose Arturo Ramon-Herrada, Inmate Number #90903-279, CI Willacy County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Willacy County, Correctional Institution, 1800 Industrial Drive, Raymonville, TX 78580 Order Denying... Institution, 1800 Industrial Drive, Raymonville, TX 78580, and when acting for or on behalf of...

  7. Superfund Record of Decision (EPA Region 6): Petro-Chemical (Turtle Bayou), Liberty County, TX. (Second remedial action), September 1991. Final report

    SciTech Connect

    Not Available

    1991-09-06

    The 500-acre Petro-Chemical (Turtle Bayou) site is in Liberty County, Texas. Current land use in the area is divided among cropland, pasture, range, forest, and small rural communities. Since 1971, numerous undocumented disposal activities occurred onsite involving primarily petrochemical wastes. The ROD for OU2 focuses on three areas of contamination at the site affecting soil and ground water contamination, known as the main waste area, the east disposal area, and the Bayou disposal area. The primary contaminants of concern affecting the soil and ground water are VOCs including benzene and xylenes; other organics including PAHs; and metals including lead. The selected remedial action for the site includes treating 302,800 cubic yards of contaminated soil onsite using in-situ vapor extraction to remove VOCs, controlling vertical air infiltration using an engineered soil and synthetic liner cap; consolidating lead-contaminated soil in the Main Waste Area, followed by capping.

  8. A Pilot Study of Changes in Environmental Knowledge and Behaviors among Head Start Employees and Parents Following Environmental Health Training in Webb County, TX.

    PubMed

    Trueblood, Amber B; Rincon, Rudy; Perales, Roger; Hollingsworth, Ryan; Miller, Claudia; McDonald, Thomas J; Cizmas, Leslie

    2016-02-01

    Head Start centers in Webb County, Texas primarily serve low-income Hispanic families disproportionately affected by environmental exposures. A total of 560 parents and employees attended environmental trainings. Pre- and post-assessments measured whether the trainings were effective at improving related knowledge and behaviors. A total of 152 parents and 94 employees signed consent forms. Only the 64 parents and 50 employees who completed all questionnaires were included in the data analysis. Paired t tests and McNemar tests found significant improvements in knowledge and behaviors related to multiple environmental topics (p < 0.05). Mean scores out of eleven for knowledge before and immediately after were 9.69 (95 % CI 9.44, 9.94) and 10.58 (95 % CI 10.42, 10.74), respectively. Mean scores out of ten for behavior before and 1 month after training were 8.00 (95 % CI 7.71, 8.29) and 9.29 (95 % CI 9.10, 9.48), respectively. This pilot study found improved knowledge and behaviors following environmental health training.

  9. 77 FR 50523 - Texas Mid-Coast National Wildlife Refuge Complex, Brazoria, Fort Bend, Matagorda, and Wharton...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... 1997 the new Land Austin's Woods Protection Plan up to Conservation Plan 70,000 acres. until the 28,000... Hudson Same as Alternative A Same as Alternative B. Photography. Woods. plus develop additional... new Bernard NWRs. trail at Brazoria NWR Field Office; provide bicycle access at Dow Woods...

  10. 75 FR 66301 - Amendment of Class E Airspace; Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ....) Ingleside, T.P. McCampbell Airport, TX (Lat. 27 54'47'' N., long. 97 12'41'' W.) Robstown, Nueces County....3-mile radius of Nueces County Airport, and within a 7.6-mile radius of Aransas County Airport,...

  11. 75 FR 55618 - Texas Disaster Number TX-00362

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Texas Disaster Number TX-00362 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4... following areas as adversely affected by the disaster. Primary Counties: Calhoun. All other information...

  12. 76 FR 70528 - Texas Disaster Number TX-00382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Texas Disaster Number TX-00382 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5... following areas as adversely affected by the disaster. Primary Counties: Briscoe, Clay, Coryell,...

  13. 76 FR 59480 - Texas Disaster Number TX-00381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Texas Disaster Number TX-00381 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2... areas as adversely affected by the disaster: Primary Counties: (Physical Damage and Economic...

  14. 76 FR 59766 - Texas Disaster Number TX-00381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Texas Disaster Number TX-00381 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... areas as adversely affected by the disaster: Primary Counties: (Physical Damage and Economic...

  15. Geothermal energy impact in Brazoria County. Final report, 15 July 1978-November 30, 1979

    SciTech Connect

    Horine, B.

    1980-06-01

    All activities performed by Alvin Community College and the University of Texas at Austin in association with the development of Geopressured-Geothermal energy are contained in this report. A discussion of the progress of the Test Well is also contained herein. Public seminars and workshops were presented to the local community. A summer institute in energy was also presented to local public school teachers. A compaign to publicize the development of the new energy resource was also waged. An overall evaluation of the project is also attached.

  16. Pleasant Bayou geopressured/geothermal testing project, Brazoria County, Texas. Final report

    SciTech Connect

    Ortego, P.K.

    1985-07-01

    Phase II-B production testing of the Pleasant Bayou No. 2 well began September 22, 1982. The test plan was designed to evaluate the capabilities of the geopressured-geothermal reservoir during an extended flow period. Tests were conducted to determine reservoir areal extent; aquifer fluid properties; fluid property change with production; information on reservoir production drive mechanism; long-term scale and corrosion control methods; and disposal well operations. Operatinal aspects of geopressured-geothermal production were also evaluated. The test was discontinued prematurely in May 1983 because of a production tubing failure. Most of the production tubing was recovered from the well and cause of the failure was determined. Plans for recompletion of the well were prepared. However, the well was not recompleted because of funding constraints and/or program rescheduling. In March 1984, the Department of Energy, Nevada Operations Office (DOE/NV) directed that the site be placed in a standby-secured condition. In August 1984, the site was secured. Routine site maintenance and security was provided during the secured period.

  17. Greening America's Capitals - Austin, TX

    EPA Pesticide Factsheets

    Report on the technical assistance project to help Austin, TX, develop a vision for the South Central Waterfront that incorporates green infrastructure to manage stormwater runoff, makes streets safer, and spurs investment.

  18. 75 FR 31677 - Amendment of Class E Airspace; Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ....) Ingleside, T.P. McCampbell Airport, TX (Lat. 27 54'47'' N., long. 97 12'41'' W.) Robstown, Nueces County... Airport, and within a 6.3-mile radius of Nueces County Airport, and within a 7.6-mile radius of...

  19. Impact of Large-scale Circulation Patterns on Surface Ozone Variability in Houston-Galveston-Brazoria

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Jia, B.; Xie, Y.

    2015-12-01

    The Bermuda High (BH) is a key driver of large-scale circulation patterns for Southeastern Texas and other Gulf coast states in summer, with the expected influence on surface ozone through its modulation of marine air inflow with lower ozone background from the Gulf of Mexico. We develop a statistical relationship through multiple linear regression (MLR) to quantify the impact of the BH variations on surface ozone variability during the ozone season in the Houston-Galveston-Brazoria (HGB) area, a major ozone nonattainment region on the Gulf Coast. We find that the variability in BH location, represented by a longitude index of the BH west edge (BH-Lon) in the MLR, explains 50-60% of the year-to-year variability in monthly mean ozone over HGB for Jun and July during 1998-2013, and the corresponding figure for Aug and Sep is 20%. Additional 30%-40% of the ozone variability for Aug and Sep can be explained by the variability in BH strength, represented by two BH intensity indices (BHI) in the MLR, but its contribution is only 5% for June and not significant for July. Including a maximum Through stepwise regression based on Akaike Information Criterion (AIC), the MLR model captures 58~72% of monthly ozone variability during Jun-Sep with a cross-validation R2 of 0.5. This observation-derived statistical relationship will be valuable to constrain model simulations of ozone variability attributable to large-scale circulation patterns.

  20. 33 CFR 80.840 - Sabine Pass, TX to Galveston, TX.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sabine Pass, TX to Galveston, TX... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.840 Sabine Pass, TX to Galveston, TX. (a) A line drawn from the Sabine Pass East Jetty Light to the seaward end of the Sabine Pass...

  1. 77 FR 65361 - Reorganization/Expansion of Foreign-z Under Alternative Site Framework; Galveston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ...; Galveston, TX Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U... or reorganization of zones; Whereas, the Board of Trustees of the Galveston Wharves, grantee of... authority to reorganize under the ASF with a service area of Galveston County, Texas, within and adjacent...

  2. TX-100 manufacturing final project report.

    SciTech Connect

    Ashwill, Thomas D.; Berry, Derek S.

    2007-11-01

    This report details the work completed under the TX-100 blade manufacturing portion of the Carbon-Hybrid Blade Developments: Standard and Twist-Coupled Prototype project. The TX-100 blade is a 9 meter prototype blade designed with bend-twist coupling to augment the mitigation of peak loads during normal turbine operation. This structural coupling was achieved by locating off axis carbon fiber in the outboard portion of the blade skins. The report will present the tooling selection, blade production, blade instrumentation, blade shipping and adapter plate design and fabrication. The baseline blade used for this project was the ERS-100 (Revision D) wind turbine blade. The molds used for the production of the TX-100 were originally built for the production of the CX-100 blade. The same high pressure and low pressure skin molds were used to manufacture the TX-100 skins. In order to compensate for the difference in skin thickness between the CX-100 and the TX-100, however, a new TX-100 shear web plug and mold were required. Both the blade assembly fixture and the root stud insertion fixture used for the CX-100 blades could be utilized for the TX-100 blades. A production run of seven TX-100 prototype blades was undertaken at TPI Composites during the month of October, 2004. Of those seven blades, four were instrumented with strain gauges before final assembly. After production at the TPI Composites facility in Rhode Island, the blades were shipped to various test sites: two blades to the National Wind Technology Center at the National Renewable Energy Laboratory in Boulder, Colorado, two blades to Sandia National Laboratory in Albuquerque, New Mexico and three blades to the United States Department of Agriculture turbine field test facility in Bushland, Texas. An adapter plate was designed to allow the TX-100 blades to be installed on existing Micon 65/13M turbines at the USDA site. The conclusion of this program is the kick-off of the TX-100 blade testing at the three

  3. Influence of the Bermuda High on interannual variability of summertime ozone in the Houston-Galveston-Brazoria region

    NASA Astrophysics Data System (ADS)

    Wang, Yuxuan; Jia, Beixi; Wang, Sing-Chun; Estes, Mark; Shen, Lu; Xie, Yuanyu

    2016-12-01

    The Bermuda High (BH) quasi-permanent pressure system is the key large-scale circulation pattern influencing summertime weather over the eastern and southern US. Here we developed a multiple linear regression (MLR) model to characterize the effect of the BH on year-to-year changes in monthly-mean maximum daily 8 h average (MDA8) ozone in the Houston-Galveston-Brazoria (HGB) metropolitan region during June, July, and August (JJA). The BH indicators include the longitude of the BH western edge (BH-Lon) and the BH intensity index (BHI) defined as the pressure gradient along its western edge. Both BH-Lon and BHI are selected by MLR as significant predictors (p < 0.05) of the interannual (1990-2015) variability of the HGB-mean ozone throughout JJA, while local-scale meridional wind speed is selected as an additional predictor for August only. Local-scale temperature and zonal wind speed are not identified as important factors for any summer month. The best-fit MLR model can explain 61-72 % of the interannual variability of the HGB-mean summertime ozone over 1990-2015 and shows good performance in cross-validation (R2 higher than 0.48). The BH-Lon is the most important factor, which alone explains 38-48 % of such variability. The location and strength of the Bermuda High appears to control whether or not low-ozone maritime air from the Gulf of Mexico can enter southeastern Texas and affect air quality. This mechanism also applies to other coastal urban regions along the Gulf Coast (e.g., New Orleans, LA, Mobile, AL, and Pensacola, FL), suggesting that the BH circulation pattern can affect surface ozone variability through a large portion of the Gulf Coast.

  4. 76 FR 36613 - Environmental Impact Statement; Nueces County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... facility that meets current highway design standards. A Feasibility Study completed in 2003 evaluated four..., as well as the No-build alternative. The Feasibility Study resulted in the identification of a... Feasibility Study, will be identified and evaluated in the EIS, in addition to the No-build Alternative,...

  5. 76 FR 73504 - Amendment of Class E Airspace; Alice, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... Airport, Agua Dulce, TX, has made this action necessary to enhance the safety and management of Instrument... Old Hoppe Place Airport, Agua Dulce, TX, due to the cancellation of all standard instrument...

  6. 76 FR 40765 - Texas Disaster #TX-00378

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... ADMINISTRATION Texas Disaster TX-00378 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Texas dated 07/05/2011. Incident: Dyer Mills Fire. Incident Period: 06/19/2011 through 06/26/2011. Effective Date:...

  7. 78 FR 48764 - Texas Disaster # TX-00413

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Texas Disaster TX-00413 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This... applications to: U.S. Small Business Administration, Processing and Disbursement Center, 14925 Kingsport...

  8. 78 FR 36631 - Texas Disaster #TX-00408

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Texas Disaster TX-00408 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This... Deadline Date: 03/12/2014. ADDRESSES: Submit completed loan applications to: U.S. Small...

  9. 75 FR 31677 - Amendment of Class E Airspace; Austin, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Austin, TX AGENCY... airspace for the Austin, TX area. Additional controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAPs) at Austin Executive Airport, Austin, TX. The FAA is taking this...

  10. 77 FR 29874 - Establishment of Class E Airspace; Freer, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Freer, TX AGENCY... airspace at Freer, TX. Controlled airspace is necessary to accommodate new Area Navigation (RNAV) Standard... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Freer, TX,...

  11. 76 FR 52563 - Special Local Regulations; Sabine River, Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Sabine River, Orange, TX...) entitled Special Local Regulations; Sabine River, Orange, TX in the Federal Register (76 FR 103). We... Events; Sabine River, Orange, TX. (a) Definitions. As used in this section ``Participant Vessel''...

  12. Big Bend National Park, TX, USA, Mexico

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Sierra del Carmen of Mexico, across the Rio Grande River from Big Bend National Park, TX, (28.5N, 104.0W) is centered in this photo. The Rio Grande River bisects the scene; Mexico to the east, USA to the west. The thousand ft. Boquillas limestone cliff on the Mexican side of the river changes colors from white to pink to lavender at sunset. This severely eroded sedimentary landscape was once an ancient seabed later overlaid with volcanic activity.

  13. 33 CFR 80.850 - Brazos River, TX to the Rio Grande, TX.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., San Bernard River, Cedar Lakes, Brown Cedar Cut, Colorado River, Matagorda Bay, Cedar Bayou, Corpus... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Brazos River, TX to the Rio... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.850 Brazos River,...

  14. 33 CFR 80.850 - Brazos River, TX to the Rio Grande, TX.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., San Bernard River, Cedar Lakes, Brown Cedar Cut, Colorado River, Matagorda Bay, Cedar Bayou, Corpus... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Brazos River, TX to the Rio... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.850 Brazos River,...

  15. 33 CFR 80.850 - Brazos River, TX to the Rio Grande, TX.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., San Bernard River, Cedar Lakes, Brown Cedar Cut, Colorado River, Matagorda Bay, Cedar Bayou, Corpus... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Brazos River, TX to the Rio... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.850 Brazos River,...

  16. 33 CFR 80.850 - Brazos River, TX to the Rio Grande, TX.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., San Bernard River, Cedar Lakes, Brown Cedar Cut, Colorado River, Matagorda Bay, Cedar Bayou, Corpus... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Brazos River, TX to the Rio... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.850 Brazos River,...

  17. 33 CFR 80.850 - Brazos River, TX to the Rio Grande, TX.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., San Bernard River, Cedar Lakes, Brown Cedar Cut, Colorado River, Matagorda Bay, Cedar Bayou, Corpus... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Brazos River, TX to the Rio... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.850 Brazos River,...

  18. 78 FR 48298 - Amendment of Class E Airspace; Commerce, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Commerce, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at Commerce, TX. Additional controlled airspace is necessary to accommodate new Area Navigation...

  19. 75 FR 11000 - Security Zone; Freeport LNG Basin, Freeport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA87 Security Zone; Freeport LNG Basin, Freeport, TX AGENCY... in the Freeport LNG Basin. This security zone is needed to protect vessels, waterfront facilities... notice of proposed rulemaking (NPRM) entitled Security Zone; Freeport LNG Basin, Freeport, TX in...

  20. 76 FR 44254 - Amendment of Class D Airspace; Denton, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Denton, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class D airspace for... proposed rulemaking to amend Class D airspace for Denton, TX, creating additional controlled airspace...

  1. 78 FR 67296 - Establishment of Class D Airspace; Mesquite, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class D Airspace; Mesquite, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class D... establish Class D airspace for Mesquite Metro Airport, Mesquite, TX (78 FR 48842) Docket No. FAA-2012-...

  2. 75 FR 55968 - Special Local Regulations, Sabine River; Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations, Sabine River; Orange, TX... temporary Special Local Regulation in the Port Arthur Captain of the Port Zone on the Sabine River, Orange... (NPRM) entitled Special Local Regulations; Sabine River, Orange, TX in the Federal Register (75 FR...

  3. 75 FR 41119 - Special Local Regulations; Sabine River, Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Sabine River, Orange, TX... River, Orange, Texas. This Special Local Regulation is intended to restrict vessels from portions of the..., testing and race in conjunction with the Orange, TX, Thunder on the Sabine boat races. The powerboat...

  4. 76 FR 30890 - Special Local Regulations; Sabine River, Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Sabine River, Orange, TX... River, Orange, Texas on September 24-25, 2011. This Special Local Regulation is intended to restrict... race in conjunction with the Orange, TX S.P.O.R.T. boat races. The powerboat race and...

  5. 77 FR 46282 - Amendment of Class E Airspace; Sweetwater, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Sweetwater, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Sweetwater, TX,...

  6. 78 FR 48295 - Amendment of Class E Airspace; Gruver, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Gruver, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at... Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Gruver, TX,...

  7. 77 FR 56761 - Amendment of Class E Airspace; Kerrville, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Kerrville, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... Class E airspace for the Kerrville, TX, area, creating additional controlled airspace at...

  8. 77 FR 66068 - Amendment of Class E Airspace; Breckenridge, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-01

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Breckenridge, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Breckenridge, TX,...

  9. 75 FR 65227 - Revocation of Class E Airspace; Franklin, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... Federal Aviation Administration 14 CFR Part 71 Revocation of Class E Airspace; Franklin, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action removes Class E... rulemaking to remove Class E airspace for Franklin, TX (75 FR 36586) Docket No. FAA-2010-0603....

  10. Hanford Single Shell Tank Leak Causes and Locations - 241-TX Farm

    SciTech Connect

    Girardot, C. L.; Harlow, D> G.

    2014-07-22

    This document identifies 241-TX Tank Farm (TX Farm) leak causes and locations for the 100 series leaking tanks (241-TX-107 and 241-TX-114) identified in RPP-RPT-50870, Rev. 0, Hanford 241-TX Farm Leak Inventory Assessment Report. This document satisfies the TX Farm portion of the target (T04) in the Hanford Federal Facility Agreement and Consent Order milestone M-045-91F.

  11. Registration of sorghum germplasm Tx3408 and Tx3409 with tolerance to sugarcane aphid [Melanaphis saccari (Zehntner)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The sorghum (Sorghum bicolor L. Moench) germplasm lines Tx3408 and Tx3409 were developed and released from Texas A&M AgriLife Research and the USDA-ARS in 2015. Both of these lines were developed from intentional crosses using the pedigree method of plant breeding. The breeding crosses for these l...

  12. Final report for the geothermal well site restoration and plug and abandonment of wells: DOE Pleasant Bayou test site, Brazoria County, Texas

    SciTech Connect

    Rinehart, Ben N.; Seigel, Ben H.

    1994-03-13

    For a variety of reasons, thousands of oil and gas wells have been abandoned in the Gulf Coast Region of the United States. Many of these wells penetrated geopressured zones whose resource potential for power generation was undervalued or ignored. The U.S. Department of Energy (DOE) Geopressured-Geothermal Research Program was chartered to improve geothermal technology to the point where electricity could be commercially produced from a substantial number of geopressured resource sites. This research program focused on relatively narrow technical issues that are unique to geopressured resources such as the ability to predict reservoir production capacity based on preliminary flow tests. Three well sites were selected for the research program. These are the Willis Hulin and Gladys McCall sites in Louisiana, and the Pleasant Bayou site in Texas. The final phase of this research project consists of plug and abandonment (P&A) of the wells and site restoration.

  13. RadNet Air Data From Fort Worth, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Fort Worth, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  14. RadNet Air Data From San Angelo, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for San Angelo, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  15. RadNet Air Data From San Antonio, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for San Antonio, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  16. RadNet Air Data From Dallas, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Dallas, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  17. RadNet Air Data From Houston, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Houston, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  18. RadNet Air Data From Austin, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Austin, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  19. RadNet Air Data From Lubbock, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Lubbock, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  20. RadNet Air Data From El Paso, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for El Paso, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  1. RadNet Air Data From Corpus Christi, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Corpus Christi, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  2. RadNet Air Data From Harlingen, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Harlingen, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation

  3. RadNet Air Data From Laredo, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Laredo, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  4. RadNet Air Data From Amarillo, TX

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Amarillo, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  5. Antibacterial Activity of Ti₃C₂Tx MXene.

    PubMed

    Rasool, Kashif; Helal, Mohamed; Ali, Adnan; Ren, Chang E; Gogotsi, Yury; Mahmoud, Khaled A

    2016-03-22

    MXenes are a family of atomically thin, two-dimensional (2D) transition metal carbides and carbonitrides with many attractive properties. Two-dimensional Ti3C2Tx (MXene) has been recently explored for applications in water desalination/purification membranes. A major success indicator for any water treatment membrane is the resistance to biofouling. To validate this and to understand better the health and environmental impacts of the new 2D carbides, we investigated the antibacterial properties of single- and few-layer Ti3C2Tx MXene flakes in colloidal solution. The antibacterial properties of Ti3C2Tx were tested against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) by using bacterial growth curves based on optical densities (OD) and colonies growth on agar nutritive plates. Ti3C2Tx shows a higher antibacterial efficiency toward both Gram-negative E. coli and Gram-positive B. subtilis compared with graphene oxide (GO), which has been widely reported as an antibacterial agent. Concentration dependent antibacterial activity was observed and more than 98% bacterial cell viability loss was found at 200 μg/mL Ti3C2Tx for both bacterial cells within 4 h of exposure, as confirmed by colony forming unit (CFU) and regrowth curve. Antibacterial mechanism investigation by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) coupled with lactate dehydrogenase (LDH) release assay indicated the damage to the cell membrane, which resulted in release of cytoplasmic materials from the bacterial cells. Reactive oxygen species (ROS) dependent and independent stress induction by Ti3C2Tx was investigated in two separate abiotic assays. MXenes are expected to be resistant to biofouling and offer bactericidal properties.

  6. 75 FR 41983 - Establishment of Class D Airspace; San Marcos, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... airspace for San Marcos Municipal Airport, San Marcos, TX. Establishment of an air traffic control tower... establishing Class D airspace at San Marcos, TX. Establishment of an air traffic control tower at San...

  7. 76 FR 53354 - Proposed Amendment of Class E Airspace; Winters, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... business hours at the office of the Central Service Center, 2601 Meacham Blvd, Fort Worth, TX 76137... airspace areas extending upward from 700 feet or more above the surface of the earth. * * * * * ASW TX...

  8. 77 FR 58800 - Radio Broadcasting Services; Knox City, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Knox City, TX AGENCY: Federal Communications... Allotments by substituting Channel 277A for vacant Channel 291A, at Knox City, Texas. The proposal is part of... at Knox City, Texas, in compliance with the Commission's minimum distance separation requirements...

  9. 76 FR 5120 - Television Broadcasting Services; El Paso, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; El Paso, TX AGENCY: Federal Communications... Comcorp of El Paso License Corp. the licensee of station KTSM-TV, channel 9, El Paso, Texas, requesting the substitution of channel 16 for channel 9 at El Paso. DATES: Comments must be filed on or...

  10. 76 FR 19276 - Television Broadcasting Services; El Paso, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; El Paso, TX AGENCY: Federal Communications... to a petition for rulemaking filed by Comcorp of El Paso License Corp. (``Comcorp''), the licensee of KTSM-TV, channel 9, El Paso, Texas, requesting the substitution of channel 16 for channel 9 at El...

  11. 76 FR 44280 - Television Broadcasting Services; El Paso, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; El Paso, TX AGENCY: Federal Communications...''), licensee of KVIA-TV, channel 7, El Paso, Texas, requesting the substitution of channel 17 for channel 7 at El Paso. KVIA-TV has experienced extensive signal coverage problems on channel 7 following the...

  12. 76 FR 28946 - Television Broadcasting Services; El Paso, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; El Paso, TX AGENCY: Federal Communications... NPG of Texas, LP (``NPG''), licensee of station KVIA-TV, El Paso, Texas, requesting the substitution of channel 17 for channel 7 at El Paso. NPG states that the proposed channel substitution will...

  13. 77 FR 32900 - Radio Broadcasting Services; Llano, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Llano, TX AGENCY: Federal Communications Commission... Congressional Review Act, see U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Radio, Radio broadcasting...: PART 73--RADIO BROADCAST SERVICES 0 1. The authority citation for part 73 continues to read as...

  14. 76 FR 13579 - Radio Broadcasting Services; Hebbronville, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Hebbronville, TX AGENCY: Federal Communications... filing procedures for comments, see 47 CFR 1.415 and 1.420. List of Subjects in 47 CFR Part 73 Radio, Radio broadcasting. For the reasons discussed in the preamble, the Federal Communications...

  15. 78 FR 4078 - Radio Broadcasting Services; Hebbronville, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Hebbronville, TX AGENCY: Federal Communications... Review Act, see 5 U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Radio, Radio broadcasting...: PART 73--RADIO BROADCAST SERVICES 0 1. The authority citation for part 73 continues to read as...

  16. 75 FR 8489 - Security Zone; Freeport Channel Entrance, Freeport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA87 Security Zone; Freeport Channel Entrance, Freeport, TX AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard has established moving security zones for certain vessels, for which the Captain of the Port, Houston-Galveston deems enhanced...

  17. 75 FR 8491 - Security Zones; Brazos River, Freeport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA87 Security Zones; Brazos River, Freeport, TX AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard has established four permanent security zones in the Brazos River in Freeport, Texas. These security zones are being put in place to...

  18. 75 FR 9859 - Television Broadcasting Services; Beaumont, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; Beaumont, TX AGENCY: Federal Communications... Freedom Broadcasting of Texas (``Freedom Broadcasting''), the licensee of KFDM(TV), channel 21, Beaumont, Texas. Freedom Broadcasting requests ] the substitution of channel 25 for channel 21 at Beaumont....

  19. 75 FR 19907 - Television Broadcasting Services; Beaumont, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; Beaumont, TX AGENCY: Federal Communications... Broadcasting of Texas, the licensee of KFDM(TV), channel 21, Beaumont, Texas, requesting the substitution of... broadcasting. 0 For the reasons discussed in the preamble, the Federal Communications Commission amends 47...

  20. 75 FR 4037 - FM TABLE OF ALLOTMENTS, BRACKETTVILLE, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... COMMISSION 47 CFR Part 73 FM TABLE OF ALLOTMENTS, BRACKETTVILLE, TX AGENCY: Federal Communications Commission... proposed deletion of this vacant allotment accommodates the new FM station application, which requests the... Rocksprings, to Brackettville, Texas, modification of the new FM station authorization. See File No....

  1. 78 FR 21337 - Radio Broadcasting Services; Matagorda, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Matagorda, TX AGENCY: Federal Communications... filed by Tejas Broadcasting Ltd., LLP (``Petitioner''), licensee of FM Station KMJR, Channel 252C2, Odem, Texas. Petitioner proposes to amend the FM Table of Allotments by substituting Channel 291A for...

  2. 76 FR 36384 - Radio Broadcasting Services; Brackettville, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Brackettville, TX AGENCY: Federal Communications... request of RF Services, Inc., licensee of a new FM station at Rocksprings, Texas, that requests the... Rocksprings, to Brackettville, Texas, and modification of the new FM station authorization. See File No....

  3. 75 FR 18776 - Regulated Navigation Area; Galveston Channel, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA11 Regulated Navigation Area; Galveston Channel, TX AGENCY... a regulated navigation area across the entire width of the Galveston Channel in the vicinity of Sector Field Office (SFO) Galveston. This regulated navigation area would require vessels to navigate...

  4. 75 FR 47713 - Regulated Navigation Area; Galveston Channel, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA11 Regulated Navigation Area; Galveston Channel, TX AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is establishing a regulated navigation... Navigation Area; Galveston Channel'' in the Federal Register (75 FR 18766). We received no comments on...

  5. 78 FR 18801 - Establishment of Class E Airspace; Beeville, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Beeville, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... Federal Register a notice of proposed rulemaking (NPRM) to establish Class E airspace at Chase...

  6. 78 FR 61179 - Establishment of Class E Airspace; Comanche, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Comanche, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... established for the airport in 2006, but the Class E airspace area to contain it was never...

  7. 75 FR 13668 - Amendment of Class E Airspace; Georgetown, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Georgetown, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... Federal Register a notice of proposed rulemaking to amend Class E airspace for Georgetown...

  8. 76 FR 53352 - Proposed Amendment of Class E Airspace; Alice, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... instrument approach procedures at Old Hoppe Place Airport, Agua Dulce, TX, has made this action necessary for..., area. Controlled airspace extending upward from 700 feet above the surface is being removed at Old... feet or more above the surface of the earth. * * * * * ASW TX E5 Alice, TX Alice International...

  9. 77 FR 71367 - Proposed Establishment of Class E Airspace; Round Mountain, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... Mountain, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to establish Class E airspace at Round Mountain, TX. Controlled... instrument approach procedures at West Ranch Airport, Round Mountain, TX. Controlled airspace is needed...

  10. 78 FR 19097 - Establishment of Class E Airspace; Round Mountain, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Round Mountain, TX... Class E airspace at Round Mountain, TX. Controlled airspace is necessary to accommodate new Area... the West Ranch Airport, Round Mountain, TX (77 FR 71367) Docket No. FAA-2012-0771. Interested...

  11. 76 FR 5303 - Proposed Amendment of Class E Airspace; Carrizo Springs, Glass Ranch Airport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ..., Glass Ranch Airport, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend Class E airspace for the Carrizo Springs, Glass... Carrizo Springs, Glass Ranch Airport, TX Carrizo Springs, Glass Ranch Airport, TX (Lat. 28 27'01''...

  12. 75 FR 81442 - Revocation of Class E Airspace; Lone Star, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... Federal Aviation Administration 14 CFR Part 71 Revocation of Class E Airspace; Lone Star, TX AGENCY... airspace at Lone Star, TX. Abandonment of the former Lone Star Steel Company ] Airport and cancellation of... the Lone Star, TX, area. The FAA is taking this action to ensure the efficient use of airspace...

  13. 75 FR 64972 - Proposed Revocation of Class E Airspace; Lone Star, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Revocation of Class E Airspace; Lone Star, TX...: This action proposes to remove Class E airspace at Lone Star, TX. Abandonment of the former Lone Star... eliminated the need for controlled airspace in the Lone Star, TX, area. The FAA is taking this action...

  14. 75 FR 6319 - Proposed Amendment of Low Altitude Area Navigation Route T-254; Houston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... altitude Area Navigation (RNAV) route T-254 in the Houston, TX, terminal area by eliminating the segment... safety and the efficient use of the navigable airspace in the Houston, TX, terminal area. DATES: Comments... amend the low altitude RNAV route T-254 in the Houston, TX, terminal area by eliminating the...

  15. 77 FR 4700 - Proposed Establishment of Class E Airspace; Freer, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Freer, TX...: This action proposes to establish Class E airspace at Freer, TX. Controlled airspace is necessary to... approach procedures at Seven C's Ranch Airport, Freer, TX. Controlled airspace is needed for the safety...

  16. 76 FR 31821 - Amendment of Class D Airspace; Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Corpus Christi, TX AGENCY... amends Class D airspace within the Corpus Christi, TX, area by updating the geographic coordinates for... the geographic coordinates, within Class D airspace, of the Cabaniss NOLF, Corpus Christi, TX,...

  17. 75 FR 18047 - Amendment of Low Altitude Area Navigation Route T-254; Houston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... Route T-254; Houston, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends low altitude Area Navigation (RNAV) route T-254 in the Houston, TX, terminal area by... the College Station, TX, VORTAC. The FAA is taking this action to eliminate a portion of T-254 that...

  18. 75 FR 39149 - Establishment of Low Altitude Area Navigation Route (T-284); Houston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... Route (T-284); Houston, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule... area navigation (RNAV) route T-284 for the Houston, TX, terminal area, is being withdrawn. As a result... Federal Register a final rule to establish RNAV route T-284 for the Houston, TX, terminal area (75...

  19. 76 FR 61775 - Texas Disaster Number TX-00381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ...: (Physical Damage and Economic Injury Loans): Harrison, Smith, Upshur. Contiguous Counties: (Economic Injury... declaration remains unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) Joseph...

  20. RXTE monitoring of the intermediate polar TX Col

    NASA Astrophysics Data System (ADS)

    Wheatley, Peter J.

    I present a preliminary analysis of ongoing monthly X-ray observations of TX Col with RXTE. The lightcurves confirm that the relative strength of spin and beat modulations is highly variable in this system, and show that the timescale of variation is shorter than one month. Changes in these modulations are thought to represent a change in accretion geometry, possibly governed by a varying accretion rate. I find some evidence that the ratio of spin to beat amplitudes is correlated with the mean count rate.

  1. Staubli TX-90XL robot qualification at the LLIHE.

    SciTech Connect

    Covert, Timothy Todd

    2010-10-01

    The Light Initiated High Explosive (LIHE) Facility uses a robotic arm to spray explosive material onto test items for impulse tests. In 2007, the decision was made to replace the existing PUMA 760 robot with the Staubli TX-90XL. A qualification plan was developed and implemented to verify the safe operating conditions and failure modes of the new system. The robot satisfied the safety requirements established in the qualification plan. A performance issue described in this report remains unresolved at the time of this publication. The final readiness review concluded the qualification of this robot at the LIHE facility.

  2. Decision support system for individualized nursing procedures: SAPIEN-Tx.

    PubMed

    Ito, M; Ramos, M P; Chern, M S; Espósito, S R; Carmagnani, M I; Cunha, I C; Piveta, V M; Nespoulos, E; Iwasa, A T; Anção, M S

    1995-01-01

    The present work proposes a Decision Support System for nursing procedures: SAPIEN-Tx. The discussion includes the acquisition, modeling , and implementation of nursing expertise professionals in Renal Transplant. It was developed to obtain better quality healthcare services, as well as an effective contribution to the nursing professional in the global assistance of their clientele. We used the KADS methodology to develop the system knowledge base. This methodology permitted us to perform the knowledge modeling with quality and organization. In opposition to the old method, errors were detected before the implementation, avoiding possible modification on the whole project structure.

  3. 60-day waste compatibility safety issues and final results for TX-244 grab samples

    SciTech Connect

    Nuzum, J.L., Fluor Daniel Hanford

    1997-02-05

    Three grab samples (244-TX-96-1, 244-TX-96-2, and 244-TX-96-3) were taken from Riser 8 of Tank 241-TX-244 on October 18, 1996, and received by 222-S Laboratory on October 18, 1996. These samples were analyzed in accordance with Compatibility Grab Sampling and Analysis Plan (TSAP) and Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) in support ofthe Waste Compatibility Program. Notifications were made in accordance with TSAP for pH and OH- analyses. Upon further review, the pH notification was deemed unnecessary, as the notification limit did not apply to this tank.

  4. 77 FR 74170 - Foreign-Trade Zone 84-Houston, TX; Notification of Proposed Production Activity; Mitsubishi...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ...; Mitsubishi Caterpillar Forklift America Inc.; (Forklift Trucks); Houston, TX The Port of Houston Authority... Caterpillar Forklift America Inc. (MCFA), located in Houston, Texas. The notification conforming to...

  5. Enplanement and All Cargo Activity

    DTIC Science & Technology

    1991-01-01

    YAKIMA AIR TERMINA YKN 65,576 $470.995 244 OR REDMOND ROBERTS FIELD RON 64,773 $466.820 245 IL BLOONINGTON/ NORMA BLOOMINGTON/NORMAL BNI 64,398 S464...CO DENVER CENTENNIAL APA 225 928 IL CHICAGO/WEST CHICAGO OUPAGE OPA 224 927 TX ANGLETON/LAKE JACKSO BRAZORIA COUNTY LBX 224 928 AK MANLEY HOT SPRINGS...REGI ALS 7.661 CO CORTEZ CORTEZ-MONTEZUMA COU CEZ 6.303 CO LAMAR LAMAR MUNI LAA 3.186 CO LAS ANIMAS CITY AND COUNTY 7V9 350 CO DENVER CENTENNIAL APA

  6. TX Cnc AS A MEMBER OF THE PRAESEPE OPEN CLUSTER

    SciTech Connect

    Zhang, X. B.; Deng, L.; Lu, P.

    2009-08-15

    We present B-, V-, and I-band CCD photometry of the W UMa-type binary system TX Cnc, which is a member star of the Praesepe open cluster. Based on the observations, new ephemeris and a revised photometric solution of the binary system were derived. Combined with the results of the radial velocity solution contributed by Pribulla et al., the absolute parameters of the system were determined. The mass, radius, and luminosity of the primary component are derived to be 1.35 {+-} 0.02 M {sub sun}, 1.27 {+-} 0.04 R {sub sun}, and 2.13 {+-} 0.11 L {sub sun}. Those for the secondary star are computed as 0.61 {+-} 0.01 M {sub sun}, 0.89 {+-} 0.03 R {sub sun}, and 1.26 {+-} 0.07 L {sub sun}, respectively. Based on these results, a distance modulus of (m - M) {sub V} = 6.34 {+-} 0.05 is determined for the star. It confirms the membership of TX Cnc to the Praesepe open cluster. The evolutionary status and the physical nature of the binary system are discussed compared with the theoretical model.

  7. Modal testing of the TX-100 wind turbine blade.

    SciTech Connect

    Reese, Sarah; Griffith, Daniel Todd; Casias, Miguel; Simmermacher, Todd William; Smith, Gregory A.

    2006-05-01

    This test report covers the SNL modal test results for two nominally identical TX-100 wind turbine blades. The TX-100 blade design is unique in that it features a passive braking, force-shedding mechanism where bending and torsion are coupled to produce desirable aerodynamic characteristics. A specific aim of this test is to characterize the coupling between bending and torsional dynamics. The results of the modal tests and the subsequent analysis characterize the natural frequencies, damping, and mode shapes of the individual blades. The results of this report are expected to be used for model validation--the frequencies and mode shapes from the experimental analysis can be compared with those of a finite-element analysis. Damping values are included in the results of these tests to potentially improve the fidelity of numerical simulations, although numerical finite element models typically have no means of predicting structural damping characteristics. Thereafter, an additional objective of the test is achieved in evaluating the test to test and unit variation in the modal parameters of the two blades.

  8. 76 FR 16294 - Drawbridge Operation Regulation; Buffalo Bayou, Mile 4.3, Houston, Harris County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... Property Rights. Civil Justice Reform This rule meets applicable standards in sections 3(a) and 3(b)(2) of... under Executive Order 13211. Technical Standards The National Technology Transfer and Advancement...

  9. 78 FR 12419 - Blacklands Railroad, Inc.-Discontinuance Exemption-In Rusk County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... Rusk Cnty., Tex., Docket No. AB 1103X. \\2\\ Blacklands was granted authority to lease and operate the... refer to Docket No. AB 1108X and must be sent to: (1) Surface Transportation Board, 395 E Street...

  10. 77 FR 65011 - Buffalo Lake National Wildlife Refuge, Randall County, TX; Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... human encroachment on the refuge. ] Wind Energy Research Conduct a diurnal avian Same as Alternative A, Same as Alternative B. activity survey and plus actively track acoustic monitoring in wind energy order... habitat for migratory waterfowl and grassland bird species. Background The CCP Process The...

  11. 75 FR 6872 - Aransas National Wildlife Refuge Complex, Aransas, Calhoun, and Refugio Counties, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-12

    ... Fish and Wildlife Service Aransas National Wildlife Refuge Complex, Aransas, Calhoun, and Refugio... (CCP) and an environmental assessment (EA) for the Aransas National Wildlife Refuge Complex (NWRC... preferred alternative, to manage this Refuge complex for the 15 years following approval of the final...

  12. 77 FR 64541 - Trinity River National Wildlife Refuge, Liberty County, TX; Final Comprehensive Conservation Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... to Refuge office. 5. Climate Change Plant trees to Same as Alternative A, Same as Alternative B... butterfly garden, and construct fishing unit; construct full- parking, and portable pier at McGuire...

  13. 75 FR 74073 - Laguna Atascosa National Wildlife Refuge, Cameron and Willacy Counties, TX; Final Comprehensive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... wetlands, estuarine wetlands, lomas (clay ridges), wind tidal flats, and barrier island beaches and ] dunes... strategies to address future establishment of artificial water sources. Selected Alternative After... species, and provide/enhance brush land, wetland and grassland habitat for ocelots, migratory...

  14. 77 FR 47660 - Attwater Prairie Chicken National Wildlife Refuge, Austin and Colorado Counties, TX; Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... refuge. Wildlife Management Issue 3: Manage three food plots Same as Alternative A; Eliminate wildlife food Wildlife Food Plots (Farming totaling up to 150 acres. plus explore additional plots. Program... addition of food plots when the species' populations expand. Visitor Services Issue 1: Provide...

  15. 76 FR 77245 - Attwater Prairie Chicken National Wildlife Refuge, Austin and Colorado Counties, TX...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... 3: Manage three food Same as Alternative A; plus Eliminate wildlife Wildlife Food Plots (Farming plots totaling up to explore additional ways to food plots. Program). 150 acres. provide supplemental food to Attwater's prairie- chicken, including capability to irrigate and addition of food plots...

  16. 77 FR 40901 - Notice of Inventory Completion: Gregg County Historical Museum, Longview, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... one possibly male adult, one adult of unknown sex, and one juvenile of unknown sex. The human remains from Burial 6 include an occipital cranial bone fragment of one adult of unknown sex. The human remains from Burial 7 include one adult of unknown sex. No known individuals were identified. The 11...

  17. 78 FR 33019 - Proposed Amendment of Class E Airspace; Commerce, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Commerce, TX AGENCY... action proposes to amend Class E airspace at Commerce, TX. Additional controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAPs) at Commerce Municipal Airport (AAF). The...

  18. 76 FR 61687 - City of College Station, TX; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission City of College Station, TX; Notice of Filing Take notice that on September... City of College Station, TX filed an application requesting that the Commission direct (1)...

  19. 75 FR 15360 - Proposed Amendment of Class E Airspace; Austin, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Austin, TX AGENCY... action proposes to amend Class E airspace in the Austin, TX area. Additional controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAPs) at Austin Executive...

  20. 78 FR 57545 - Proposed Amendment of Class D Airspace; Dallas, Addison Airport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... Airport, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking... Class D airspace ceiling at Addison Airport, Dallas, TX, is being withdrawn. Upon review, the FAA... 6, 2013, a NPRM was published in the Federal Register proposing to amend the Addison Airport Class...

  1. 76 FR 28888 - Revocation of Class E Airspace; Gruver Cluck Ranch Airport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... Federal Aviation Administration 14 CFR Part 71 Revocation of Class E Airspace; Gruver Cluck Ranch Airport... removes Class E airspace at Gruver, Cluck Ranch Airport, TX. The airport has been abandoned, thereby eliminating the need for controlled airspace in the Gruver, Cluck Ranch Airport, TX, area. The FAA is...

  2. 76 FR 22011 - Amendment of Class E Airspace; Carizzo Springs, Glass Ranch Airport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Carizzo Springs, Glass Ranch... amends Class E airspace for the Carizzo Springs, Glass Ranch Airport, TX, airspace area, to accommodate... rulemaking to amend Class E airspace for the Carizzo Springs, Glass Ranch Airport, TX, airspace...

  3. 75 FR 16336 - Establishment of Low Altitude Area Navigation Route (T-284); Houston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Houston, TX, terminal area, to expedite the handling of Instrument Flight Rules (IFR) overflight aircraft transitioning busy terminal airspace. The FAA is taking this action to enhance the safe and efficient use of the navigable airspace in the Houston, TX, terminal area. DATES: Effective date 0901 UTC, July 29, 2010....

  4. 76 FR 49285 - Amendment of Class D Airspace; Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Corpus Christi, TX AGENCY... Register June 2, 2011, ] amending Class D airspace at Cabaniss Navy Outlying Field (NOLF), Corpus Christi... Cabaniss NOLF, Corpus Christi, TX (76 FR 31821, Docket No. FAA-2010-1171). Subsequent to publication,...

  5. Registration of perennial Sorghum bicolor x S. propinquum line 'PSH12TX09'

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A novel sorghum x Sorghum propinquum recombinant inbred line, named PSSH12TX09, was identified that successfully overwintered across plant hardiness zones 8a, 8b, and 9a between 2013 and 2015. Overwintering perenniality of PSSH12TX09 exceeded 90% at all locations across both evaluation years, with ...

  6. 78 FR 31429 - Proposed Amendment of Class E Airspace; Mason, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ...; Mason, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend Class E airspace at Mason, TX. Additional controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAP) at Mason...

  7. 77 FR 47519 - Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... SECURITY Coast Guard 33 CFR Part 100 Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast..., call or email Mr. Scott Whalen. U.S. Coast Guard Marine Safety Unit Port Arthur, TX; telephone...

  8. 75 FR 66303 - Revocation of Restricted Areas R-3807 Glencoe, LA, and R-6320 Matagorda, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... Federal Aviation Administration 14 CFR Part 73 RIN 2120-AA66 Revocation of Restricted Areas R-3807 Glencoe, LA, and R-6320 Matagorda, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action removes Restricted Areas R-3807 Glencoe, LA, and R-6320 Matagorda, TX....

  9. 76 FR 1513 - Amendment of Class E Airspace; Horseshoe Bay, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... airspace for Horseshoe Bay, TX. Decommissioning of the Horseshoe Bay Resort non-directional beacon (NDB) at Horseshoe Bay Resort Airport, Horseshoe Bay, TX, has made this action necessary to enhance the safety and management of Instrument Flight Rule (IFR) operations at the airport. DATES: Effective date 0901 UTC,...

  10. 78 FR 28801 - Foreign-Trade Zone 117-Orange, TX, Authorization of Production Activity, Signal International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... Foreign-Trade Zones Board Foreign-Trade Zone 117--Orange, TX, Authorization of Production Activity, Signal International Texas GP, LLC (Shipbuilding), Orange, TX On January 10, 2013, the Foreign Trade Zone of Southeast...-Trade Zones (FTZ) Board on behalf of Signal International Texas GP, LLC, in Orange, Texas....

  11. Photometry Of The Semi-regular Variable Tx Tau

    NASA Astrophysics Data System (ADS)

    Wyman, Katherine; Spear, G.; McLin, K.; Cominsky, L.; Mankiewicz, L.; Reichart, D.; Ivarsen, K.

    2009-12-01

    We report V-band and I-band photometry for the SRA type variable TX Tau. Photometry was obtained using the robotic telescope GORT at the Hume Observatory (NASA funded through Sonoma State University) and the PROMPT robotic telescopes at Cerro Tololo Inter-American Observatory (NSF and NASA funded through the University of North Carolina). Photometry was also obtained using the PI of the Sky optical transient search system at Las Campanas Observatory developed by a consortium of institutions in Poland. Modern periods are determined, the V-band and I-band light curves are compared, and V-I colors are derived. It is possible that the classification for this variable should be reconsidered.

  12. Mass flow in the interacting binary TX Ursae Majoris

    NASA Technical Reports Server (NTRS)

    Mccluskey, G. E., Jr.; Mccluskey, C. P. S.; Kondo, Y.

    1988-01-01

    Twenty-two far-ultraviolet and 23 near-ultraviolet high resolution IUE spectra of the interactive Algol-type binary TX Ursae Majoris (B8 V + F-K III-IV) were analyzed in order to determine the nature of the mass flow occurring in this system. Absorption features due to high-temperature ions of Si IV, C IV, and N V are always present. The resonance lines of Al III, Fe II, Mg II and Si IV show strong phase and secular variations indicative of gas streaming and circumstellar/circumbinary material. Radial velocities as high as 500 to 600 km/sec are present. The gas flow is particularly prominent in 1985 between phases 0.7 and 0.0. The system is more active than U Sagittae and as active as U Cephei.

  13. CX-100 and TX-100 blade field tests.

    SciTech Connect

    Holman, Adam (USDA-Agriculture Research Service, Bushland, TX); Jones, Perry L.; Zayas, Jose R.

    2005-12-01

    In support of the DOE Low Wind Speed Turbine (LWST) program two of the three Micon 65/13M wind turbines at the USDA Agricultural Research Service (ARS) center in Bushland, Texas will be used to test two sets of experimental blades, the CX-100 and TX-100. The blade aerodynamic and structural characterization, meteorological inflow and wind turbine structural response will be monitored with an array of 75 instruments: 33 to characterize the blades, 15 to characterize the inflow, and 27 to characterize the time-varying state of the turbine. For both tests, data will be sampled at a rate of 30 Hz using the ATLAS II (Accurate GPS Time-Linked Data Acquisition System) data acquisition system. The system features a time-synchronized continuous data stream and telemetered data from the turbine rotor. This paper documents the instruments and infrastructure that have been developed to monitor these blades, turbines and inflow.

  14. Chemical Contamination of the Lower Rio Grande near Laredo, TX

    NASA Astrophysics Data System (ADS)

    Flores, B.; Ren, J.; Krishnamurthy, S.; Belzer, W.

    2006-12-01

    The Rio Grande River stretches over 2000 miles from the southern Rocky Mountains in Colorado to the tip of Texas where the Rio Grande meets the Gulf of Mexico. It is the natural boundary between U.S. and Mexico from El Paso, TX, to Brownsville, TX. The communities along the border heavily rely upon the Rio Grande as a primary source of water for consumption, agricultural uses, supporting wildlife and recreation. For many years the Rio Grande has been polluted with municipal, industrial, agricultural and farming contaminants from both sides of the border. This pollution has led to the extinction or reduction of certain wildlife species as well as affecting the health of the residences along the border. Even though great strides have been made in monitoring the Rio Grande, there has been a lack of intense monitoring data collection for pollutants such as pesticides. Three sampling sites including Manadas Creek, the Rio Grande River at International Bridge I, and USGS monitoring site 08459200 off of Highway 83 were chosen. The water quality parameters focused include temperature, pH, conductivity, dissolve oxygen (DO), salinity, total dissolved solids, nutrients, metals and pesticides. Preliminary results have shown elevated concentration of total phosphorus and ortho-phosphorus in the Manadas Creek site. Organochlorinated pesticides such as heptachlor and 4, 4 DDE were detected at various concentrations at all sites and endrin aldehyde was found at Manadas Creek site. This research has provided more information on the current chemical contamination level of the Rio Grande in the Laredo area.

  15. Backwater Flooding in San Marcos, TX from the Blanco River

    NASA Technical Reports Server (NTRS)

    Earl, Richard; Gaenzle, Kyle G.; Hollier, Andi B.

    2016-01-01

    Large sections of San Marcos, TX were flooded in Oct. 1998, May 2015, and Oct. 2015. Much of the flooding in Oct. 1998 and Oct. 2015 was produced by overbank flooding of San Marcos River and its tributaries by spills from upstream dams. The May 2015 flooding was almost entirely produced by backwater flooding from the Blanco River whose confluence is approximately 2.2 miles southeast of downtown. We use the stage height of the Blanco River to generate maps of the areas of San Marcos that are lower than the flood peaks and compare those results with data for the observed extent of flooding in San Marcos. Our preliminary results suggest that the flooding occurred at locations more than 20 feet lower than the maximum stage height of the Blanco River at San Marcos gage (08171350). This suggest that the datum for either gage 08171350 or 08170500 (San Marcos River at San Marcos) or both are incorrect. There are plans for the U.S. Army Corps of Engineers to construct a Blanco River bypass that will divert Blanco River floodwaters approximately 2 miles farther downstream, but the $60 million price makes its implementation problematic.

  16. TX-100/water/1-butyl-3-methylimidazolium hexafluorophosphate microemulsions.

    PubMed

    Gao, Yanan; Han, Shuaibing; Han, Buxing; Li, Ganzuo; Shen, Dong; Li, Zhonghao; Du, Jimin; Hou, Wanguo; Zhang, Gaoyong

    2005-06-21

    Both ionic liquids and water are typical green solvents. In this work, the phase behavior of the ternary system consisting of ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF6), TX-100, and water was determined at 25.0 degrees C. The water-in-bmimPF6, bicontinuous, and bmimPF6-in-water microregions of the microemulsions were identified by cyclic voltammetry method using potassium ferrocyanide K4Fe(CN)6 as the electroactive probe. Dynamic light scattering (DLS) and the UV-vis method were used to characterize the microemulsions. It was demonstrated that the hydrodynamic diameter (Dh) of the bmimPF6-in-water microemulsions is nearly independent of the water content but increases with increasing bmimPF6 content due to the swelling of the micelles by the ionic liquid. The UV-vis further confirmed the existence of water domains in the water-in-bmimPF6 microemulsions, and the salt potassium ferricyanide K3Fe(CN)6 could be dissolved in the water domains.

  17. ORNL measurements at Hanford Waste Tank TX-118

    SciTech Connect

    Koehler, P.E.; Mihalczo, J.T.

    1995-02-01

    A program of measurements and calculations to develop a method of measuring the fissionable material content of the large waste storage tanks at the Hanford, Washington, site is described in this report. These tanks contain radioactive waste from the processing of irradiated fuel elements from the plutonium-producing nuclear reactors at the Hanford site. Time correlation and noise analysis techniques, similar to those developed for and used in the Nuclear Weapons Identification System at the Y-12 Plant in Oak Ridge, Tennessee, will be used at the Hanford site. Both ``passive`` techniques to detect the neutrons emitted spontaneously from the waste in the tank and ``active`` techniques using AmBe and {sup 252}Cf neutron sources to induce fissions will be used. This work is divided into three major tasks: (1) development of high-sensitivity neutron detectors that can selectively count only neutrons in the high {gamma} radiation fields in the tanks, (2) Monte Carlo neutron transport calculations using both the KENO and MCNP codes to plan and analyze the measurements, and (3) the measurement of time-correlated neutrons by time and frequency analysis to distinguish spontaneous fission from sources inside the tanks. This report describes the development of the detector and its testing in radiation fields at the Radiation Calibration Facility at Oak Ridge National Laboratory and in tank TX-118 at the 200 W area at Westinghouse Hanford Company.

  18. 75 FR 15992 - Revision of Prohibited Area P-49; Crawford, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... amends Prohibited Area 49 (P-49) Crawford, TX. While the United States Secret Service (USSS) recognizes... designation. Continuous. Using agency. United States Secret Service, Washington, DC. Issued in Washington,...

  19. E3 Success Story - Reducing Electrical Demand in San Antonio, TX

    EPA Pesticide Factsheets

    To meet its goal of reducing electrical demand by 9 megawatts CPS Energy in San Antonio, TX partnered with the Texas Manufacturing Assistance Center (TMAC) and the Southwest Research Institute to provide lean, clean and energy efficiency training.

  20. 75 FR 22712 - Proposed Establishment of Class D Airspace; San Marcos, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... control tower has made controlled airspace necessary at San Marcos Municipal Airport. The FAA is taking... establishing Class D airspace at San Marcos Municipal Airport, San Marcos, TX. An air traffic control...

  1. 76 FR 30396 - Deloitte Financial Advisory Services LLP, Real Estate Consulting, Houston, TX; Amended...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Financial Advisory Services LLP, Real Estate Consulting, Houston, TX; Amended Certification Regarding... of Deloitte Financial Advisory Services LLP, Real Estate Consulting, Houston, Texas (subject firm... subject worker group supplies real estate valuation services for the subject firm. The Department, on...

  2. 76 FR 12788 - Environmental Impact Statement for a Proposed Urban Rail system in Austin, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... 78705, Telephone (512) 404- 1900. Thursday, April 7, 2011; 5 p.m. to 8 p.m.; at the George Washington Carver Museum (Museum Foyer), 1161 Angelina Street, Austin, TX 78702, Telephone (512) 974-4926....

  3. Tank characterization report for single-shell tank 241-TX-107

    SciTech Connect

    Sasaki, L.M., Westinghouse Hanford

    1996-07-10

    This document summarizes the information on the historical uses, present status, and the sampling and analysis results of waste stored in Tank 241-TX-107. This report supports the requirements of Tri-party Agreement Milestone M-44-09.

  4. TOMORROW: EPA Recognizing Gulf Guardian Award Winners in Corpus Christi, TX

    EPA Pesticide Factsheets

    DALLAS - (July 29, 2015) The U.S. Environmental Protection Agency's (EPA) Gulf of Mexico Program will hold the 13 th annual Gulf Guardians Awards ceremony in Corpus Christi, TX, this Thursday, July 30.

  5. 76 FR 26658 - Proposed Establishment of Class E Airspace; Ranger, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... also be examined during normal business hours at the office of the Central Service Center, 2601 Meacham... Airspace areas extending upward from 700 feet or more above the surface of the earth. * * * * * ASW TX...

  6. 76 FR 1511 - Amendment of Class D Airspace; Fort Worth NAS JRB (Carswell Field), TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... navigation aids, at the request of the U.S. Navy, that are listed in the description. This action does not...) Class D airspace, Fort Worth, TX, and the navigation aids, to coincide with the FAAs...

  7. 33 CFR 165.809 - Security Zones; Port of Port Lavaca-Point Comfort, Point Comfort, TX and Port of Corpus Christi...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Lavaca-Point Comfort, Point Comfort, TX and Port of Corpus Christi Inner Harbor, Corpus Christi, TX. 165... Lavaca-Point Comfort, Point Comfort, TX and Port of Corpus Christi Inner Harbor, Corpus Christi, TX. (a) Location. The following area is designated as a security zone: all waters of the Corpus Christi...

  8. ArgTX-636, a polyamine isolated from spider venom: A novel class of melanogenesis inhibitors.

    PubMed

    Verdoni, Marion; Roudaut, Hermine; De Pomyers, Harold; Gigmes, Didier; Bertin, Denis; Luis, José; Bengeloune, Abd Haq; Mabrouk, Kamel

    2016-11-15

    To discover new molecules with an inhibitory activity of melanogenesis a hundred of scorpions, snakes, spiders and amphibians venoms were screened for their capacity to inhibit mushroom tyrosinase using 3,4-l-dihydroxyphenylalanine (l-DOPA) as substrate. The Argiope lobata spider venom proved to be the most active. HPLC fraction containing Argiotoxine-636 (ArgTX-636), a polyamine known for its numerous biological activities, was found to also show a good regulation activity of melanogenesis by inhibiting DOPA and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidases activities, wore by tyrosinase (TYR) and tyrosinase-related protein 1 (TRP-1), respectively. Our results demonstrate that ArgTX-636 reduced the mushroom tyrosinase activity in a dose-dependent way with a maximal half inhibitory concentration (IC50) value of 8.34μM, when l-DOPA is used as substrate. The Lineweaver-Burk study showed that ArgTX-636 is a mixed type inhibitor of the diphenolase activity. Moreover, ArgTX-636 inhibits DHICA oxydase activity of mushroom tyrosinase activity with IC50 at 41.3μM. ArgTX-636 has no cytotoxicity in B16F10 melanoma cells at concentrations up to 42.1μM. The effect of ArgTX-636 on melanogenesis showed that melanin production in B16F10 melanoma cell decreased by approximatively 70% compared to untreated cells. ArgTX-636 displayed no significant effect on the TYR expression while the protein level of TRP-1 decreased in B16F10 cells. Thus, ArgTX-636 could have particular interest for cosmetic and/or pharmaceutical use in order to reduce important dermatoses in black and mixed skins.

  9. Synthesis and electrochemical performance of Ti3C2Tx with hydrothermal process

    NASA Astrophysics Data System (ADS)

    Wang, Libo; Zhang, Heng; Wang, Bo; Shen, Changjie; Zhang, Chuanxiang; Hu, Qianku; Zhou, Aiguo; Liu, Baozhong

    2016-09-01

    In this study, a simple hydrothermal method has been developed to prepare Ti3C2Tx from Ti3AlC2 as a high-performance electrode material for supercapacitors. This method is environmentally friendly and has a low level of danger. The morphology and structure of the Ti3C2Tx can be controlled by hydrothermal reaction time, temperature and NH4F amounts. The prepared Ti3C2Tx was characterized by X-ray diffraction, field emission scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy and Brunauer-Emmet-Teller. The results show that the prepared Ti3C2Tx is terminated by O, OH, and F groups. The electrochemical properties of the Ti3C2Tx sample exhibit specific capacitance up to 141 Fcm-3 in 3 M KOH aqueous electrolyte, and even after 1000 cycles, no significant degradation of the volumetric capacitance was observed. These results indicate that the Ti3C2Tx material prepared by this hydrothermal method can be used in high performance supercapacitors.

  10. 40 CFR 52.2285 - Control of evaporative losses from the filling of gasoline storage vessels in the Houston and San...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... containers and delivery vessels. (b) This section is applicable to the following counties in Texas: Harris... terminals) in Bexar, Brazoria, Galveston and Harris Counties, any gasoline bulk plants in Harris County, and... Bexar, Brazoria, Galveston, and Harris Counties which is subject to Texas Air Control Board Regulation...

  11. 40 CFR 52.2285 - Control of evaporative losses from the filling of gasoline storage vessels in the Houston and San...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... containers and delivery vessels. (b) This section is applicable to the following counties in Texas: Harris... terminals) in Bexar, Brazoria, Galveston and Harris Counties, any gasoline bulk plants in Harris County, and... Bexar, Brazoria, Galveston, and Harris Counties which is subject to Texas Air Control Board Regulation...

  12. Aerospace medicine at Brooks AFB, TX: hail and farewell.

    PubMed

    Nunneley, Sarah A; Webb, James T

    2011-05-01

    With the impending termination of USAF operations at Brooks Air Force Base (AFB) in San Antonio, TX, it is time to consider its historic role in Aerospace Medicine. The base was established in 1917 as a flight training center for the U.S. Army Air Service and in 1926 became home to its School of Aviation Medicine. The school moved to San Antonio's Randolph Field in 1931, but in 1959 it returned to Brooks where it occupied new facilities to support its role as a national center for U.S. Air Force aerospace medicine, including teaching, clinical medicine, and research. The mission was then expanded to encompass support of U.S. military and civilian space programs. With the abrupt termination of the military space program in 1969, research at Brooks focused on clinical aviation medicine and support of advanced military aircraft while continuing close cooperation with NASA in support of orbital spaceflight and the journey to the Moon. Reorganization in the 1990s assigned all research functions at Brooks to the Human Systems Division and its successors, leaving to USAFSAM the missions related to clinical work and teaching. In 2002 the USAF and the city of San Antonio implemented shared operation of Brooks as a "City-Base" in the hope of deflecting threatened closure. Nevertheless, under continuing pressure to consolidate military facilities in the United States, the 2005 Base Closure and Realignment Commission ordered Brooks closed by 2011, with its aerospace medicine functions relocated to new facilities at Wright-Patterson AFB in Dayton, OH.

  13. 77 FR 47816 - Foreign-Trade Zone 12-McAllen, TX Application for Subzone TST NA TRIM, LLC Hidalgo, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 12--McAllen, TX Application for Subzone TST NA TRIM, LLC... TST NA TRIM, LLC, located in Hidalgo, Texas. The application was submitted pursuant to the...

  14. Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom

    PubMed Central

    Lisboa, Antonio; Melaré, Rodolfo; Franco, Junia R. B.; Bis, Carolina V.; Gracia, Marta; Ponce-Soto, Luis A.; Marangoni, Sérgio; Rodrigues-Simioni, Léa; da Cruz-Höfling, Maria Alice

    2016-01-01

    Neuromuscular preparations exposed to B. marajoensis venom show increases in the frequency of miniature end-plate potentials and twitch tension facilitation followed by presynaptic neuromuscular paralysis, without evidences of muscle damage. Considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and SNAP25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and SNAP25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (CBC) exposed in vitro to BmjeTX-I and BmjeTX-II toxins from B. marajoensis venom. CBC incubated with toxins showed irreversible twitch tension blockade and unaffected KCl- and ACh-evoked contractures, and the positive colabelling of acetylcholine receptors confirmed that their action was primarily at the motor nerve terminal. Hypercontraction and loose myofilaments and synaptic vesicle depletion and motor nerve damage indicated that the toxins displayed both myotoxic and neurotoxic effect. The blockade resulted from interference on synaptophysin, synaptobrevin, and SNAP25 proteins leading to the conclusion that BmjeTX-I and BmjeTX-II affected neurotransmitter release machinery by preventing the docking of synaptic vesicles to the axolemma of the nerve terminal. PMID:27635261

  15. Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch.

    PubMed

    Wang, Kun; Yin, Shi-Jin; Lu, Meng; Yi, Hong; Dai, Chao; Xu, Xiu-Jing; Cao, Zhi-Jian; Wu, Ying-Liang; Li, Wen-Xin

    2006-11-01

    The gene encoding the BmalphaTX14 (alpha-neurotoxin TX14) protein, derived from the cDNA library of the Chinese scorpion Buthus martensii Karsch, was expressed in Pichia pastoris. The recombinant protein was purified by metal chelate affinity chromatography and gel filtration chromatography. Using patch-clamp technique, electrophysiological activity of rBmalphaTX14 was identified. In the neurons isolated from mice trigeminal root ganglion, the Na+ current amplitude was reduced by 80% under whole cell patch-clamp recording. There were no apparent modifications to the gating mechanism in the presence of rBmalphaTX14. Although BmalphaTX14 shared a high amino acid sequence similarity with other typical alpha-toxins, it has different effects on neurons. Further electrophysiological analysis suggested that rBmalphaTX14 selectively blocked Na+ channels and is a member of a new group of scorpion toxins.

  16. RCRA Assessment Plan for Single-Shell Tank Waste Management Area TX-TY

    SciTech Connect

    Horton, Duane G.

    2007-03-26

    WMA TX-TY contains underground, single-shell tanks that were used to store liquid waste that contained chemicals and radionuclides. Most of the liquid has been removed, and the remaining waste is regulated under the RCRA as modi¬fied in 40 CFR Part 265, Subpart F and Washington State’s Hazardous Waste Management Act . WMA TX-TY was placed in assessment monitoring in 1993 because of elevated specific conductance. A groundwater quality assessment plan was written in 1993 describing the monitoring activities to be used in deciding whether WMA TX-TY had affected groundwater. That plan was updated in 2001 for continued RCRA groundwater quality assessment as required by 40 CFR 265.93 (d)(7). This document further updates the assessment plan for WMA TX-TY by including (1) information obtained from ten new wells installed at the WMA after 1999 and (2) information from routine quarterly groundwater monitoring during the last five years. Also, this plan describes activities for continuing the groundwater assessment at WMA TX TY.

  17. Capacitance of Ti3C2Tx MXene in ionic liquid electrolyte

    NASA Astrophysics Data System (ADS)

    Lin, Zifeng; Barbara, Daffos; Taberna, Pierre-Louis; Van Aken, Katherine L.; Anasori, Babak; Gogotsi, Yury; Simon, Patrice

    2016-09-01

    Ti3C2Tx MXene, a two-dimensional (2D) early transition metal carbide, has shown an extremely high volumetric capacitance in aqueous electrolytes, but in a narrow voltage window (less than 1.23 V). The utilization of MXene materials in ionic liquid electrolytes with a large voltage window has never been addressed. Here, we report the preparation of the Ti3C2Tx MXene ionogel film by vacuum filtration for use as supercapacitor electrodes operating in 1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI-TFSI) neat ionic liquid electrolyte. Due to the disordered structure of the Ti3C2Tx hydrogel film and a stable spacing after vacuum drying, achieved through ionic liquid electrolyte immersion of the Ti3C2Tx hydrogel film, the Ti3C2Tx surface became accessible to EMI+ and TFSI- ions. A capacitance of 70 F g-1 together with a large voltage window of 3 V was obtained at a scan rate of 20 mV s-1 in neat EMI-TFSI electrolyte. The electrochemical signature indicates a capacitive behavior even at a high scan rate (500 mV s-1) and a high power performance. This work opens up the possibilities of using MXene materials with various ionic liquid electrolytes.

  18. Dosimetric characteristics of novalis Tx system with high definition multileaf collimator.

    PubMed

    Chang, Zheng; Wang, Zhiheng; Wu, Q Jackie; Yan, Hui; Bowsher, Jim; Zhang, Junan; Yin, Fang-Fang

    2008-10-01

    A new Novalis Tx system equipped with a high definition multileaf collimator (HDMLC) recently became available to perform both image-guided radiosurgery and conventional radiotherapy. It is capable of delivering a highly conformal radiation dose with three energy modes: 6 MV photon energy, 15 MV photon energy, and 6 MV photon energy in a stereotactic radiosurgery mode with 1000 MU/min dose rate. Dosimetric characteristics of the new Novalis Tx treatment unit with the HDMLC are systematically measured for commissioning. A high resolution diode detector and miniion-chamber detector are used to measure dosimetric data for a range of field sizes from 4 x 4 mm to 400 x 400 mm. The commissioned Novalis Tx system has passed the RPC stereotactic radiosurgery head phantom irradiation test. The Novalis Tx system not only expands its capabilities with three energy modes, but also achieves better beam conformity and sharer beam penumbra with HDMLC. Since there is little beam data information available for the new Novalis Tx system, we present in this work the dosimetric data of the new modality for reference and comparison.

  19. Capacitance of Ti3C2Tx MXene in Ionic Liquid Electrolyte

    DOE PAGES

    Lin, Zifeng; Barbara, Daffos; Taberna, Pierre-Louis; ...

    2016-04-14

    Ti3C2Tx MXene, a two-dimensional (2D) early transition metal carbide, has shown an extremely high volumetric capacitance in aqueous electrolytes, but in a narrow voltage window (less than 1.23 V). The utilization of MXene materials in ionic liquid electrolytes with a large voltage window has never been addressed. Here, we report the preparation of the Ti3C2Tx MXene ionogel film by vacuum filtration for use as supercapacitor electrodes operating in 1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI-TFSI) neat ionic liquid electrolyte. Due to the disordered structure of the Ti3C2Tx hydrogel film and a stable spacing after vacuum drying, achieved through ionic liquid electrolyte immersion of themore » Ti3C2Tx hydrogel film, the Ti3C2Tx surface became accessible to EMI+ and TFSI- ions. A capacitance of 70 F g-1 together with a large voltage window of 3 V was obtained at a scan rate of 20 mV s-1 in neat EMI-TFSI electrolyte. The electrochemical signature indicates a capacitive behavior even at a high scan rate (500 mV s-1) and a high power performance. This work opens up the possibilities of using MXene materials with various ionic liquid electrolytes.« less

  20. Effects of Receive-Only Inserts on SAR, B1+ Field and Tx Coil Performance

    PubMed Central

    Krishnamurthy, Narayanan; Zhao, Tiejun; Ibrahim, Tamer S

    2013-01-01

    Purpose To evaluate the effect of different cylindrical and close conforming receive only array designs on spin excitation and specific absorption rate (SAR) of a 7 Tesla transmit only head coil. Materials and Methods We developed FDTD models of different receive only array geometries. Cylindrical and close fitting helmet arrays with varying copper trace widths; a TEM Tx coil model and two head models were used in numerical simulations. Tx coil coupling was experimentally measured and validated with FDTD modeling. Results Changing copper trace width of loops in array models caused subtle changes in RF absorption (<5%). Changes in SAR distribution were observed in the head models with Rx-only inserts. Peak SAR increased (−1 to +15%) in different tissues for a mean B1+ in the brain of 2 μT. Total absorption in the head models for 1 Watt forward power increased (5 to 21%) in the heads with Rx-only inserts. Changes in RF absorption with different Rx-inserts indicate a change in RF radiation of the Tx coil even when changes in B1+ and coupling between ports of Tx coil were minimal. Conclusion Changes in local/global SAR and subtle changes in B1+ field distributions were observed with the presence of Rx-only inserts. Thus, incorporation of the receive-only array effects are needed when evaluating SAR and designing RF transmit pulse waveform parameters for shimming and/or Tx-SENSE for 7 T MRI. PMID:23913474

  1. LyeTx I, a potent antimicrobial peptide from the venom of the spider Lycosa erythrognatha.

    PubMed

    Santos, D M; Verly, R M; Piló-Veloso, D; de Maria, M; de Carvalho, M A R; Cisalpino, P S; Soares, B M; Diniz, C G; Farias, L M; Moreira, D F F; Frézard, F; Bemquerer, M P; Pimenta, A M C; de Lima, M E

    2010-06-01

    LyeTx I, an antimicrobial peptide isolated from the venom of Lycosa erythrognatha, known as wolf spider, has been synthesised and its structural profile studied by using the CD and NMR techniques. LyeTx I has shown to be active against bacteria (Escherichia coli and Staphylococcus aureus) and fungi (Candida krusei and Cryptococcus neoformans) and able to alter the permeabilisation of L: -alpha-phosphatidylcholine-liposomes (POPC) in a dose-dependent manner. In POPC containing cholesterol or ergosterol, permeabilisation has either decreased about five times or remained unchanged, respectively. These results, along with the observed low haemolytic activity, indicated that antimicrobial membranes, rather than vertebrate membranes seem to be the preferential targets. However, the complexity of biological membranes compared to liposomes must be taken in account. Besides, other membrane components, such as proteins and even specific lipids, cannot be discarded to be important to the preferential action of the LyeTx I to the tested microorganisms. The secondary structure of LyeTx I shows a small random-coil region at the N-terminus followed by an alpha-helix that reached the amidated C-terminus, which might favour the peptide-membrane interaction. The high activity against bacteria together with the moderate activity against fungi and the low haemolytic activity have indicated LyeTx I as a good prototype for developing new antibiotic peptides.

  2. Mobilization of Bacillus thuringiensis plasmid pTX14-3.

    PubMed

    Andrup, L; Bendixen, H H; Jensen, G B

    1995-05-01

    The Bacillus thuringiensis subsp. israelensis (Bti) plasmid pTX14-3 has been reported to contain a gene, mob14-3, with considerable homology to genes encoding mobilization proteins from other gram-positive bacteria. We have used the aggregation-mediated conjugation system recently discovered in Bti to compare the mobilization kinetics of different derivatives of plasmid pTX14-3. Plasmid pTX14-3 has been found to replicate by the rolling-circle mechanism and to contain a locus suppressing the formation of high-molecular-weight DNA. We found that deleting a DNA fragment containing this locus increased the transfer frequency about twofold. The mobilization frequency of the plasmid containing the intact mob14-3 gene did not indicate a mobilization-enhancing activity of the encoded polypeptide. However, the presence of the mob14-3 gene seemed to increase the stability of the plasmid in exponential growth.

  3. Cardiorespiratory Effect of Brevetoxin (PbTx-2) in Conscious, Tethered Rats

    DTIC Science & Technology

    1988-11-07

    calculation of median-effective dose (ED5 0 or LD5 0 ) and instructions in their use. Biometrics 8, 249. FIGURE LEGENDS Figure 1. Dose - response curve showing...8217). Figure 2. Dose - response curve showing effect of 1 hr infusion of PbTx-2 on core temperature in rats. (solid = 100 ug/kg; dashed = 50 ug/kg; dotted... Dose - response curve showing effect of 1 hr infusion of PbTx-2 on peripheral temperature in rats. [solid = 100 ug/kg; dashed = 50 ug/kg; dotted = 25

  4. Tank 241-TX-118 vapor sampling and analysis tank characterization report

    SciTech Connect

    Huckaby, J.L.

    1995-05-31

    Tank 241-TX-118 headspace gas and vapor samples were collected and analyzed to help determine the potential risks to tank farm workers due to fugitive emissions from the tank. The drivers and objectives of waste tank headspace sampling and analysis are discussed in {open_quotes}Program Plan for the Resolution of Tank Vapor Issues.{close_quotes} Tank 241-TX-118 was vapor sampled in accordance with {open_quotes}Data Quality Objectives for Generic In-Tank Health and Safety Issue Resolution.{close_quotes}

  5. Tank 241-TX-105 vapor sampling and analysis tank characterization report

    SciTech Connect

    Huckaby, J.L.

    1995-05-31

    Tank 241-TX-105 headspace gas and vapor samples were collected and analyzed to help determine the potential risks to tank farm workers due to fugitive emissions from the tank. The drivers and objectives of waste tank headspace sampling and analysis are discussed in {open_quotes}Program Plan for the Resolution of Tank Vapor Issues.{close_quotes} Tank 241-TX-105 was vapor sampled in accordance with {open_quotes}Data Quality Objectives for Generic In-Tank Health and Safety Issue Resolution.{close_quotes}

  6. 78 FR 4124 - Foreign-Trade Zone 68-El Paso, TX, Application for Subzone, Expeditors International of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... Foreign-Trade Zones Board Foreign-Trade Zone 68--El Paso, TX, Application for Subzone, Expeditors International of Washington, Inc., El Paso, TX An application has been submitted to the Foreign-Trade Zones Board (the Board) by the City of El Paso, grantee of FTZ 68, requesting special-purpose subzone...

  7. 76 FR 6613 - AP Gas & Electric (TX), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (TX), LLC; Supplemental Notice That Initial Market-Based... supplemental notice in the above-referenced proceeding of AP Gas & Electric (TX), LLC's application for...

  8. 78 FR 9907 - TGP Development Company, LLC; TGP Flying Cloud Holdings, LLC; WEC TX Company, LLC v. Arizona...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission TGP Development Company, LLC; TGP Flying Cloud Holdings, LLC; WEC TX Company... Development Company, LLC, TGP Flying Cloud Holdings, LLC, and WEC TX Company, LLC (collectively,...

  9. [Genomic DNA sequences and functional expression, purification of BmalphaTX14 neurotoxin from scorpion Buthus martensii Karsch].

    PubMed

    Lü, Meng; Wang, Kun; Cao, Zhi-Jian; Jiang, Da-He; Mao, Xin; Li, Wen-Xin

    2005-11-01

    Based on the full-length cDNA of BmalphaTX14 from Chinese scorpion Buthus martensii Karsch (BmK), gene of the mature peptide of BmalphaTX14 was cloned into the yeast expression vector pPIC9K. After transforming, screening and inducing, tricine-SDS-PAGE and Western blot proved that rBmalphaTX14 protein was expressed in the medium for up to 84 hours, getting nearly 120 mg/L. Recombinant BmalphaTX14 was purified rapidly and efficiently through Ni-NTA-agarose, polyethylene glycol precipitation and gel filtration chromatography. The purified rBmalphaTX14 proved to have the anti-insect activity by toxicity assay. Meanwhile, genomic gene of BmalphaTX14 was cloned and sequenced by PCR method, sequence analysis of this gene showed that BmalphaTX14 had an intron of 408 base pairs located at the signal peptide encoding region, which was similar with the characteristic of other alpha-type sodium ion-channel toxin. Considering both the genomic organization and the peptide function, BmaTX14 proved to be a membership belonging to alpha-type sodium ion-channel toxin.

  10. 75 FR 65232 - Security Zones; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... measures necessary. In addition, it establishes security zones encompassing the mooring basins of LNG carriers while they are moored at the Golden Pass LNG facility in Sabine, TX and/or the Sabine Pass LNG... ] mooring basins at the Golden Pass LNG facility in Sabine, TX and the Sabine Pass LNG facility located...

  11. 76 FR 1519 - Security Zones; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... encompassing the mooring basins of LNG carriers while they are moored at the Golden Pass LNG facility in Sabine, TX and/or the Sabine Pass LNG facility located in Cameron Parish, LA. DATES: This rule is effective... mooring basins at the Golden Pass LNG facility in Sabine, TX and the Sabine Pass LNG facility located...

  12. rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans

    PubMed Central

    Xu, Jie; Wan, Lu; Teng, Kaixuan; Xiang, Jin; Zhang, Rui; Huang, Zebo; Liu, Yongmei; Li, Wenhua; Liu, Xin

    2016-01-01

    The scorpion has been extensively used in various pharmacological profiles or as food supplies. The exploration of scorpion venom has been reported due to the presence of recombinant peptides. rBmαTX14 is an α-neurotoxin extracted from the venom gland of the East Asian scorpion Buthus martensii Karsch and can affect ion channel conductance. Here, we investigated the functions of rBmαTX14 using the Caenorhabditis elegans model. Using western blot analysis, rBmαTX14 was shown to be expressed both in the cytoplasm and inclusion bodies in the E.coli Rosetta (DE3) strain. Circular dichroism spectroscopy analysis demonstrated that purified rBmαTX14 retained its biological structures. Next, feeding nematodes with E.coli Rosetta (DE3) expressing rBmαTX14 caused extension of the life span and promoted the locomotion of the nematodes. In addition, we identified several genes that play various roles in the life span and locomotion of C. elegans through microarray analysis and quantitative real-time PCR. Furthermore, if the amino acid site H15 of rBmαTX14 was mutated, rBmαTX14 no longer promoted the C. elegans life span. In conclusion, the results not only demonstrated the functions and mechanism of rBmαTX14 in C. elegans, but also provided the new sight in the utility of recombinant peptides from scorpion venom. PMID:27611314

  13. 33 CFR 165.819 - Security Zone; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Sabine-Neches Waterway, TX. (a) Location. (1) The following LNG facility mooring basins are designated as fixed security zones whenever LNG carriers are moored within them: (i) Golden Pass LNG, Sabine TX: All...°45′50″ N, 093°55′17″ W. (ii) Sabine Pass LNG, Cameron Parish, LA: All mooring basin waters north of...

  14. 33 CFR 165.819 - Security Zone; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Sabine-Neches Waterway, TX. (a) Location. (1) The following LNG facility mooring basins are designated as fixed security zones whenever LNG carriers are moored within them: (i) Golden Pass LNG, Sabine TX: All...°45′50″ N, 093°55′17″ W. (ii) Sabine Pass LNG, Cameron Parish, LA: All mooring basin waters north of...

  15. 33 CFR 165.819 - Security Zone; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Sabine-Neches Waterway, TX. (a) Location. (1) The following LNG facility mooring basins are designated as fixed security zones whenever LNG carriers are moored within them: (i) Golden Pass LNG, Sabine TX: All...°45′50″ N, 093°55′17″ W. (ii) Sabine Pass LNG, Cameron Parish, LA: All mooring basin waters north of...

  16. Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins

    PubMed Central

    Pimentel, Cyril; M'Barek, Sarrah; Visan, Violetta; Grissmer, Stephan; Sampieri, François; Sabatier, Jean-Marc; Darbon, Hervé; Fajloun, Ziad

    2008-01-01

    Agitoxin 2 (AgTx2) is a 38-residue scorpion toxin, cross-linked by three disulfide bridges, which acts on voltage-gated K+ (Kv) channels. Maurotoxin (MTX) is a 34-residue scorpion toxin with an uncommon four-disulfide bridge reticulation, acting on both Ca2+-activated and Kv channels. A 39-mer chimeric peptide, named AgTx2-MTX, was designed from the sequence of the two toxins and chemically synthesized. It encompasses residues 1–5 of AgTx2, followed by the complete sequence of MTX. As established by enzyme cleavage, the new AgTx2-MTX molecule displays half-cystine pairings of the type C1–C5, C2–C6, C3–C7, and C4–C8, which is different from that of MTX. The 3D structure of AgTx2-MTX solved by 1H-NMR, revealed both α-helical and β-sheet structures, consistent with a common α/β scaffold of scorpion toxins. Pharmacological assays of AgTx2-MTX revealed that this new molecule is more potent than both original toxins in blocking rat Kv1.2 channel. Docking simulations, performed with the 3D structure of AgTx2-MTX, confirmed this result and demonstrated the participation of the N-terminal domain of AgTx2 in its increased affinity for Kv1.2 through additional molecular contacts. Altogether, the data indicated that replacement of the N-terminal domain of MTX by the one of AgTx2 in the AgTx2-MTX chimera results in a reorganization of the disulfide bridge arrangement and an increase of affinity to the Kv1.2 channel. PMID:18042681

  17. Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins.

    PubMed

    Pimentel, Cyril; M'Barek, Sarrah; Visan, Violetta; Grissmer, Stephan; Sampieri, François; Sabatier, Jean-Marc; Darbon, Hervé; Fajloun, Ziad

    2008-01-01

    Agitoxin 2 (AgTx2) is a 38-residue scorpion toxin, cross-linked by three disulfide bridges, which acts on voltage-gated K(+) (Kv) channels. Maurotoxin (MTX) is a 34-residue scorpion toxin with an uncommon four-disulfide bridge reticulation, acting on both Ca(2+)-activated and Kv channels. A 39-mer chimeric peptide, named AgTx2-MTX, was designed from the sequence of the two toxins and chemically synthesized. It encompasses residues 1-5 of AgTx2, followed by the complete sequence of MTX. As established by enzyme cleavage, the new AgTx2-MTX molecule displays half-cystine pairings of the type C1-C5, C2-C6, C3-C7, and C4-C8, which is different from that of MTX. The 3D structure of AgTx2-MTX solved by (1)H-NMR, revealed both alpha-helical and beta-sheet structures, consistent with a common alpha/beta scaffold of scorpion toxins. Pharmacological assays of AgTx2-MTX revealed that this new molecule is more potent than both original toxins in blocking rat Kv1.2 channel. Docking simulations, performed with the 3D structure of AgTx2-MTX, confirmed this result and demonstrated the participation of the N-terminal domain of AgTx2 in its increased affinity for Kv1.2 through additional molecular contacts. Altogether, the data indicated that replacement of the N-terminal domain of MTX by the one of AgTx2 in the AgTx2-MTX chimera results in a reorganization of the disulfide bridge arrangement and an increase of affinity to the Kv1.2 channel.

  18. 77 FR 66743 - Radio Broadcasting Services; Crowell, Knox City, Quanah, and Rule, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Crowell, Knox City, Quanah, and Rule, TX AGENCY... of Allotments by substituting Channel 293A for vacant Channel 291A at Knox City, Texas; Channel 288C2.... Channel 293A can be allotted to Knox City, Texas at reference coordinates 33-25-55 NL and 99-47-43 WL,...

  19. 77 FR 60103 - Approval of Subzone Status; TST NA TRIM, LLC; Hidalgo, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Approval of Subzone Status; TST NA TRIM, LLC; Hidalgo, TX On August 3, 2012, the... limit of FTZ 12, on behalf of TST NA TRIM, LLC, in Hidalgo, Texas. The application was processed...

  20. Encounters with Wisdom: A Case Study of Community Worker Reflection Circles in San Antonio, TX

    ERIC Educational Resources Information Center

    Arispe, Don D.

    2013-01-01

    This case study focuses upon the transformational experiences of 28 social service and pastoral workers engaged in a Reflection Circle Process (RCP) in San Antonio, TX. The RCP involves the writing of a holistic journal entry, known as a process note, coupled with an in-depth exploration of the note with the help of a group of trusted peers, known…

  1. 76 FR 15857 - Radio Broadcasting Services; Early and Lake Brownwood, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Early and Lake Brownwood, TX AGENCY: Federal... the Congressional Review Act, see U.S.C. 801(a)(1)(A). List Of Subjects in 47 CFR Part 73 Radio, Radio... CFR part 73 as follows: PART 73--RADIO BROADCAST SERVICES 0 1. The authority citation for Part...

  2. 78 FR 13857 - Foreign-Trade Zone 84-Houston, TX; Notification of Proposed Production Activity; Toshiba...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... Foreign-Trade Zones Board Foreign-Trade Zone 84--Houston, TX; Notification of Proposed Production Activity; Toshiba International Corporation (Hybrid Electric Vehicle Motors and Generators Production) The Port of Houston Authority, grantee of FTZ 84, submitted a notification of proposed production activity on...

  3. 76 FR 73587 - Foreign-Trade Zone 183-Austin, Tx; Site Renumbering Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... Foreign-Trade Zones Board Foreign-Trade Zone 183--Austin, Tx; Site Renumbering Notice Foreign-Trade Zone... currently consists of 8 ``sites'' totaling some 2,818 acres in the Austin area. The current updates does not... follows: Site 1 (33 acres)--Interchange w/n the Austin Enterprise Zone, located at Bolm Road and...

  4. Streptomyces venezuelae TX-TL - a next generation cell-free synthetic biology tool.

    PubMed

    Moore, Simon J; Lai, Hung-En; Needham, Hannah; Polizzi, Karen M; Freemont, Paul S

    2017-01-31

    Streptomyces venezuelae is a promising chassis in synthetic biology for fine chemical and secondary metabolite pathway engineering. The potential of S. venezuelae could be further realized by expanding its capability with the introduction of its own in vitro transcription-translation (TX-TL) system. TX-TL is a fast and expanding technology for bottom-up design of complex gene expression tools, biosensors and protein manufacturing. Herein, we introduce a S. venezuelae TX-TL platform by reporting a streamlined protocol for cell-extract preparation, demonstrating high-yield synthesis of a codon-optimized sfGFP reporter and the prototyping of a synthetic tetracycline-inducible promoter in S. venezuelae TX-TL based on the tetO-TetR repressor system. The aim of this system is to provide a host for the homologous production of exotic enzymes from Actinobacteria secondary metabolism in vitro. As an example, the authors demonstrate the soluble synthesis of a selection of enzymes (12-70 kDa) from the Streptomyces rimosus oxytetracycline pathway.

  5. 78 FR 31839 - Establishment of Class E Airspace; Beeville-Chase Field, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Beeville-Chase Field, TX... Register of March 28, 2013. The title and airspace designation are corrected to read Beeville-Chase Field... Register document FAA 2012-0821, Airspace Docket No. 12- ASW-8, establishes Class E Airspace at Chase...

  6. Preliminary tank characterization report for single-shell tank 241-TX-115: Best-Basis inventory

    SciTech Connect

    Kupfer, M.J.

    1997-09-02

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-115 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  7. Preliminary tank characterization report for single-shell tank 241-TX-116: best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-06-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-116 was performed, and a bost-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  8. Preliminary tank characterization report for single-shell tank 241-TX-104: best-basis inventory

    SciTech Connect

    Kupfer, M.J.

    1997-09-02

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-104 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  9. Preliminary tank characterization report for single-shell tank 241-TX-105: best-basis inventory

    SciTech Connect

    Kupfer, M.J.

    1997-08-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-105 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  10. Preliminary tank characterization report for single-shell tank 241-TX-117: best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-06-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-117 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  11. Preliminary tank characterization report for single-shell tank 241-TX-110: Best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-08-26

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-110 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  12. Preliminary tank characterization report for single-shell tank 241-TX-109: best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-08-26

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-109 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  13. Preliminary tank characterization report for single-shell tank 241-TX-102: best-basis inventory

    SciTech Connect

    Kupfer, M.J.

    1997-09-02

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-102 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task.

  14. 78 FR 14909 - Amendment of Class B Airspace Description; Houston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... Flexibility Act. The FAA's authority to issue rules regarding aviation safety is found in Title 49 of the... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Amendment of Class B Airspace Description; Houston, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule, technical...

  15. 78 FR 70900 - Proposed Modification of Area Navigation (RNAV) Route Q-20, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... (RNAV) Route Q-20, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify RNAV route Q-20 in support of the Houston Optimization of Airspace and Procedures in a Metroplex (OAPM) project. This proposed action re-aligns Q-20...

  16. 75 FR 12726 - Expansion/Reorganization of Foreign-Trade Zone 149; Port Freeport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion/Reorganization of Foreign-Trade Zone 149; Port Freeport, TX Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C....

  17. 78 FR 26799 - Waterway Suitability Assessment for Expansion of Liquefied Gas Terminals; Beaumont, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ... SECURITY Coast Guard Waterway Suitability Assessment for Expansion of Liquefied Gas Terminals; Beaumont, TX... construction to expand or modify marine terminal operations in an existing facility handling Liquefied Natural... LHG marine traffic in the associated waterway. Martin Operating Partnership's Stanolind Cut...

  18. EPA Announces 2015 ENERGY STAR Certified Manufacturing Plants, Two Midlothian, TX, facilities among those recognized

    EPA Pesticide Factsheets

    DALLAS - (Feb. 24, 2016) The U.S. Environmental Protection Agency (EPA) announced today that two facilities in Midlothian, TX-the Holcim and Martin Marietta Materials cement facilities-are among the 70 manufacturing plants across the nation that ach

  19. 78 FR 55214 - Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The...

  20. 77 FR 2448 - Special Local Regulation; HITS Triathlon; Corpus Christi Bayfront, Corpus Christi, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulation; HITS Triathlon; Corpus Christi Bayfront, Corpus Christi, TX AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard is establishing a temporary Special Local Regulation in the Corpus Christi Bayfront area...

  1. 75 FR 52065 - SharePlus Federal Bank, Plano, TX; Approval of Conversion Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision SharePlus Federal Bank, Plano, TX; Approval of Conversion Application Notice is hereby given that on August 12, 2010, the Office of Thrift Supervision approved the application...

  2. 33 CFR 165.827 - Regulated Navigation Area; Galveston Channel, TX.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Regulated Navigation Area; Galveston Channel, TX. 165.827 Section 165.827 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED...

  3. 33 CFR 165.827 - Regulated Navigation Area; Galveston Channel, TX.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Regulated Navigation Area; Galveston Channel, TX. 165.827 Section 165.827 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED...

  4. 75 FR 13433 - Safety Zone; Invista Inc Facility Docks, Victoria Barge Canal, Victoria, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Invista Inc Facility Docks, Victoria Barge Canal, Victoria, TX AGENCY: Coast Guard, DHS. ACTION: Interim final rule with request for comments. SUMMARY: The Coast Guard is establishing a safety zone for a partial blockage of the Victoria Barge...

  5. 46 CFR 7.105 - Marquesas Keys, FL to Rio Grande, TX.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Marquesas Keys, FL to Rio Grande, TX. 7.105 Section 7.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY... the seaward limits of the territorial sea (as defined in 33 CFR 2.22(a)(1)) to Rio Grande, Texas...

  6. 46 CFR 7.105 - Marquesas Keys, FL to Rio Grande, TX.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Marquesas Keys, FL to Rio Grande, TX. 7.105 Section 7.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY... the seaward limits of the territorial sea (as defined in 33 CFR 2.22(a)(1)) to Rio Grande, Texas...

  7. 46 CFR 7.105 - Marquesas Keys, FL to Rio Grande, TX.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Marquesas Keys, FL to Rio Grande, TX. 7.105 Section 7.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY... the seaward limits of the territorial sea (as defined in 33 CFR 2.22(a)(1)) to Rio Grande, Texas...

  8. 75 FR 66013 - Proposed Amendment of Class E Airspace; Horseshoe Bay, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Resort Airport. Controlled airspace is necessary for the safety and management of IFR operations at the... Bay Resort non-directional beacon (NDB) at Horseshoe Bay Resort Airport, Horseshoe Bay, TX, has made this action necessary for the safety and management of Instrument Flight Rules (IFR) operations at...

  9. 78 FR 34121 - Notice of Inventory Completion: Dallas Water Utilities, Dallas, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... National Park Service Notice of Inventory Completion: Dallas Water Utilities, Dallas, TX AGENCY: National Park Service, Interior. ] ACTION: Notice. SUMMARY: The Dallas Water Utilities has completed an... funerary objects should submit a written request to Dallas Water Utilities. If no additional...

  10. County by County in Ohio Genealogy. Revised.

    ERIC Educational Resources Information Center

    Khouw, Petta; And Others

    The State Library of Ohio's genealogy collection of over 8,000 items is listed by county. Within each county listing the sources are designated as atlases, cemetery and death records, census records (the majority from the 1800's), family-church-Bible records, marriage records, or county and township histories. Vital records consist of material…

  11. The solution structure of BmTx3B, a member of the scorpion toxin subfamily alpha-KTx 16.

    PubMed

    Wang, Yuefeng; Chen, Xiang; Zhang, Naixia; Wu, Gong; Wu, Houming

    2005-02-01

    This article reports the solution structure of BmTx3B (alpha-KTx16.2), a potassium channel blocker belonging to the subfamily alpha-KTx16, purified from the venom of the Chinese scorpion Buthus martensi Karsch. In solution, BmTx3B assumes a typical CSalphabeta motif, with an alpha-helix connected to a triple-stranded beta-sheet by 3 disulfide bridges, which belongs to the first structural group of short-chain scorpion toxins. On the other hand, BmTx3B is quite different from other toxins (such as ChTx and AgTx2) of this group in terms of the electrostatic and hydrophobic surface distribution. The functional surface (beta-face) of the molecule is characterized by less basic residues (only 2: Lys28 and Arg35) and extra aromatic residues (Phe1, Phe9, Trp15, and Tyr37). The peptide shows a great preference for the Kca1.1 channel over the Kv channel (about a 10(3)-fold difference). The model of BmTx3B/Kca1.1 channel complex generated by docking and dynamic simulation reveals that the stable binding between the BmTx3B and Kca1.1 channel is favored by a number of aromatic pi-pi stacking interactions. The influences of these structural features on the kinetic behavior of the toxin binding to Kca1.1 channel are also discussed.

  12. Binding sites and actions of Tx1, a neurotoxin from the venom of the spider Phoneutria nigriventer, in guinea pig ileum.

    PubMed

    Santos, R G; Diniz, C R; Cordeiro, M N; De Lima, M E

    1999-12-01

    Tx1, a neurotoxin isolated from the venom of the South American spider Phoneutria nigriventer, produces tail elevation, behavioral excitation and spastic paralysis of the hind limbs after intracerebroventricular injection in mice. Since Tx1 contracts isolated guinea pig ileum, we have investigated the effect of this toxin on acetylcholine release, as well as its binding to myenteric plexus-longitudinal muscle membranes from the guinea pig ileum. [125I]-Tx1 binds specifically and with high affinity (Kd = 0.36 +/- 0.02 nM) to a single, non-interacting (nH = 1.1), low capacity (Bmax 1.1 pmol/mg protein) binding site. In competition experiments using several compounds (including ion channel ligands), only PhTx2 and PhTx3 competed with [125I]-Tx1 for specific binding sites (K0.5 apparent = 7.50 x 10(-4) g/l and 1.85 x 10(-5) g/l, respectively). PhTx2 and PhTx3, fractions from P. nigriventer venom, contain toxins acting on sodium and calcium channels, respectively. However, the neurotoxin PhTx2-6, one of the isoforms found in the PhTx2 pool, did not affect [125I]-Tx1 binding. Tx1 reduced the [3H]-ACh release evoked by the PhTx2 pool by 33%, but did not affect basal or KCl-induced [3H]-ACh release. Based on these results, as well as on the homology of Tx1 with toxins acting on calcium channels (omega-Aga IA and IB) and its competition with [125I]-omega-Cono GVIA in the central nervous system, we suggest that the target site for Tx1 may be calcium channels.

  13. 77 FR 22558 - Foreign-Trade Zone 155-Calhoun and Victoria Counties, TX; Application for Reorganization Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... significantly greater flexibility in the designation of new ``usage-driven'' FTZ sites for operators/users... formally filed on April 9, 2012. FTZ 155 was approved by the Board on October 24, 1988 (Board Order 398, 55 FR 44510, 11/3/88), and expanded on June 18, 2008 (Board Order 1565, 73 FR 36038-36039, 6/25/08)....

  14. 78 FR 1935 - Union Pacific Railroad Company-Abandonment and Discontinuance Exemption-in Cameron County, TX...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ...) Mack H. Shumate, Jr., 101 North Wacker Drive, 1920, Chicago, IL 60606. Replies to the joint petition.... Campbell, Director, Office of Proceedings. Derrick A. Gardner, Clearance Clerk. BILLING CODE 4915-01-P...

  15. 75 FR 61706 - Reorganization of Foreign-Trade Zone 113 Under Alternative Site Framework; Ellis County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 113 Under Alternative Site Framework; Ellis... Board adopted the alternative site framework (ASF) in December 2008 (74 FR 1170, 01/12/09; correction 74... alternative site framework is approved, subject to the FTZ Act and the Board's regulations, including...

  16. Cost-effectiveness analysis of TxDOT CNG fleet conversion, volume 2

    NASA Astrophysics Data System (ADS)

    Euritt, M. A.; Taylor, D. B.; Mahmassani, H.

    1992-08-01

    Increased emphasis on energy efficiency and air quality has resulted in a number of state and federal initiatives examining the use of alternative fuels for motor vehicles. Texas' program for alternate fuels includes compressed natural gas (CNG). Based on an analysis of 30-year life-cycle costs, development of a natural gas vehicle (NGV) program for the Texas Department of Transportation (TxDOT) would cost about $47 million (in 1991 dollars). These costs include savings from lower priced natural gas, infrastructure costs for a fast-fueling station, vehicle costs, and operating costs. The 30-year life-cycle costs translate into an average annual vehicle cost increase of $596, or about 4.9 cents more per vehicle mile of travel. Based on the cost-effectiveness analysis and assumptions, there are currently no TxDOT stations suitable for conversion to compressed natural gas.

  17. The cytotoxic mechanism of karlotoxin 2 (KmTx 2) from Karlodinium veneficum (Dinophyceae)

    PubMed Central

    Deeds, Jonathan R.; Hoesch, Robert E.; Place, Allen R.; Kao, Joseph P.Y.

    2015-01-01

    This study demonstrates that the polyketide toxin karlotoxin 2 (KmTx 2) produced by Karlodinium veneficum, a dinoflagellate associated with fish kills in temperate estuaries worldwide, alters vertebrate cell membrane permeability. Microfluorimetric and electrophysiological measurements were used to determine that vertebrate cellular toxicity occurs through non-selective permeabilization of plasma membranes, leading to osmotic cell lysis. Previous studies showed that KmTx 2 is lethal to fish at naturally-occurring concentrations measured during fish kills, while sub-lethal doses severely damage gill epithelia. This study provides a mechanistic explanation for the association between K. veneficum blooms and fish kills that has long been observed in temperate estuaries worldwide. PMID:25546005

  18. Disposal of hazardous materials from TxDOT activities. Final report, September 1992-August 1994

    SciTech Connect

    Stallard, M.; Corapcioglu, M.Y.; Beavers, T.; Beck, B.; Mehevec, A.

    1994-11-01

    The process of purchasing, storing, handling and disposal of hazardous waste is demanding. The Texas Department of Transportation deals with many such compounds every day in performing its duty of maintaining over 70,000 miles of Texas roadway. With the new demands being placed on all users of hazardous materials by the new EPA guidelines, procedures must be enacted to ensure TxDOT`s compliance with these ever-changing regulations. The placement of full-time safety and hazardous materials coordinators in each district office will help to ensure that employees follow reporting procedures and use disposal guidelines. The report will discuss these actions and others that might help TxDOT in this task.

  19. GOC-TX: A Reliable Ticket Synchronization Application for the Open Science Grid

    NASA Astrophysics Data System (ADS)

    Hayashi, Soichi; Gopu, Arvind; Quick, Robert

    2011-12-01

    One of the major operational issues faced by large multi-institutional collaborations is permitting its users and support staff to use their native ticket tracking environment while also exchanging these tickets with collaborators. After several failed attempts at email-parser based ticket exchanges, the OSG Operations Group has designed a comprehensive ticket synchronizing application. The GOC-TX application uses web-service interfaces offered by various commercial, open source and other homegrown ticketing systems, to synchronize tickets between two or more of these systems. GOC-TX operates independently from any ticketing system. It can be triggered by one ticketing system via email, active messaging, or a web-services call to check for current sync-status, pull applicable recent updates since prior synchronizations to the source ticket, and apply the updates to a destination ticket. The currently deployed production version of GOC-TX is able to synchronize tickets between the Numara Footprints ticketing system used by the OSG and the following systems: European Grid Initiative's system Global Grid User Support (GGUS) and the Request Tracker (RT) system used by Brookhaven. Additional interfaces to the BMC Remedy system used by Fermilab, and to other instances of RT used by other OSG partners, are expected to be completed in summer 2010. A fully configurable open source version is expected to be made available by early autumn 2010. This paper will cover the structure of the GOC-TX application, its evolution, and the problems encountered by OSG Operations group with ticket exchange within the OSG Collaboration.

  20. 77 FR 65360 - Foreign-Trade Zone 168-Dallas/Ft. Worth, TX; Notification of Proposed Production Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... Production Activity, Richemont North America, Inc. dba Cartier (Eyewear Assembly/Kitting), Grand Prairie, TX...), located in Grand Prairie, Texas. The notification conforming to the requirements of the regulations of...

  1. 78 FR 11816 - Foreign-Trade Zone 168-Dallas/Ft. Worth, TX, Authorization of Production Activity, Richemont...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... Activity, Richemont North America, Inc. dba Cartier (Eyewear Assembly/Kitting), Grand Prairie, TX On... North America, Inc. dba Cartier, within FTZ 168--Site 4, in Grand Prairie, Texas. ] The notification...

  2. EPA Announces 2015 ENERGY STAR Certified Manufacturing Plants, Allergan Pharmaceuticals facility in Waco, TX, among those recognized

    EPA Pesticide Factsheets

    DALLAS - (Feb. 24, 2016) The U.S. Environmental Protection Agency (EPA) announced today that the Allergan Pharmaceuticals facility in Waco, TX, is among the 70 manufacturing plants across the nation that achieved ENERGY STAR certification for their

  3. 78 FR 4125 - Foreign-Trade Zone 265-Conroe, TX; Authorization of Production Activity; Bauer Manufacturing, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... Manufacturing, Inc. (Pile Drivers and Boring Machinery), Conroe, TX On September 12, 2012, the City of Conroe... Zones (FTZ) Board on behalf of Bauer Manufacturing, Inc., within FTZ 265--Site 1, in Conroe, Texas....

  4. Evidence for reduced lymphatic CSF absorption in the H-Tx rat hydrocephalus model

    PubMed Central

    Rammling, Matthias; Madan, Meenu; Paul, Leena; Behnam, Babak; Pattisapu, Jogi V

    2008-01-01

    Background There is mounting evidence that spinal fluid absorption takes place not only at the arachnoid villi, but also at several extracranial sites, which might serve as a reserve mechanism for, or be primarily involved in the absorption of CSF in hydrocephalus. Methods We compared the nasal lymphatic pathway in congenital Hydrocephalus-Texas (H-Tx) rats in unaffected and affected hydrocephalic (HC) siblings with that of control Sprague Dawley (SD) rat pups. The animals were examined after immediate post mortem injection of Evan's blue dye into the cisterna magna at 6 and 10 days of age. The specimens were evaluated for amount of dye penetration into the nasal passages. Results We found more dye visualization in the olfactory regions of control SD (14/16 at P6, 14/16 at P10) and unaffected H-Tx (13/17 at P6, 13/16 at P10) compared with HC animals (0/14 at P6, 3/15 at P10). This difference was more pronounced at 10 days of age. The dye was not visualized in the cervical lymph nodes or venous channels in these acute experiments. Conclusion The results of this study suggest that nasal lymphatic cerebrospinal fluid absorption is reduced in the H-Tx rat hydrocephalus model. PMID:18925964

  5. PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

    PubMed Central

    Binda, Nancy Scardua; Porto Petruceli Carayon, Charles; Agostini, Rafael Mourão; do Nascimento Pinheiro, Ana Cristina; Nascimento Cordeiro, Marta; Romano Silva, Marco Aurélio; Figueira Silva, Juliana; Rita Pereira, Elizete Maria; da Silva Junior, Claudio Antonio; de Castro Junior, Célio José; Sena Guimarães, Andre Luiz; Gomez, Marcus Vinicius

    2016-01-01

    The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% ± 3.6%, indicating the severity of the insult. PhTx3-4 treatment increased the amplitude of the b-wave, which was almost equivalent to the control retinas that were not submitted to injury. The PhTx3-4 functional protection of the retinas recorded on the ERG also was observed in the neuroprotection of retinal cells. NMDA-induced injury reduced live cells in the retina layers and the highest reduction, 84%, was in the ganglion cell layer. Notably, PhTx3-4 treatment caused a remarkable reduction of dead cells in the retina layers, and the highest neuroprotective effect was in the ganglion cells layer. NMDA-induced cytotoxicity of the retina increased the release of glutamate, reactive oxygen species (ROS) production and oxidative stress. PhTx3-4 treatment reduced glutamate release, ROS production and oxidative stress measured by malondialdehyde. Thus, we presented for the first time evidence of in vivo neuroprotection from NMDA-induced retinal injury by PhTx3-4 (-ctenitoxin-Pn3a), a spider toxin that blocks N-P/Q calcium channels. PMID:26978403

  6. Unmasking Snake Venom of Bothrops leucurus: Purification and Pharmacological and Structural Characterization of New PLA2 Bleu TX-III

    PubMed Central

    Marangoni, Fábio André; Ponce-Soto, Luis Alberto; Marangoni, Sergio; Landucci, Elen Cristina Teizem

    2013-01-01

    Bleu TX-III was isolated from Bothrops leucurus snake venom on one-step analytical chromatography reverse phase HPLC, was homogeneous on SDS-PAGE, and was confirmed by Q-Tof Ultima API ESI/MS (TOF MS mode) mass spectrometry in 14243.8 Da. Multiple alignments of Bleu TX-III show high degree of homology with basic PLA2 myotoxins from other Bothrops venoms. Our studies on local and systemic myotoxicity “in vivo” reveal that Bleu TX-III is myotoxin with local but not systemic action due to the decrease in the plasmatic CK levels when Bleu TX-III is administrated by intravenous route in mice (dose 1 and 5 μg). And at a dose of 20 μg myotoxin behaves like a local and systemic action. Bleu TX-III induced moderate marked paw edema, evidencing the local increase in vascular permeability. The inflammatory events induced in the mice (I.M.) were investigated. The increase in the levels of IL-1, IL-6, and TNF-α was observed in the plasma. It is concluded that Bleu TX-III induces inflammatory events in this model. The enzymatic phospholipid hydrolysis may be relevant to these phenomena. Bothrops leucurus venom is still not extensively explored, and the knowledge of its toxins separately through the study of structure/function will contribute for a better understanding of its action mechanism. PMID:23509815

  7. Receiver deghosting in the t-x domain based on super-Gaussianity

    NASA Astrophysics Data System (ADS)

    Lu, Wenkai; Xu, Ziqiang; Fang, Zhongyu; Wang, Ruiliang; Yan, Chengzhi

    2017-01-01

    Deghosting methods in the time-space (t-x) domain have attracted a lot of attention because of their flexibility for various source/receiver configurations. Based on the well-known knowledge that the seismic signal has a super-Gaussian distribution, we present a Super-Gaussianity based Receiver Deghosting (SRD) method in the t-x domain. In our method, we denote the upgoing wave and its ghost (downgoing wave) as a single seismic signal, and express the relationship between the upgoing wave and its ghost using two ghost parameters: the sea surface reflection coefficient and the time-shift between the upgoing wave and its ghost. For a single seismic signal, we estimate these two parameters by maximizing the super-Gaussianity of the deghosted output, which is achieved by a 2D grid search method using an adaptively predefined discrete solution space. Since usually a large number of seismic signals are mixed together in a seismic trace, in the proposed method we divide the seismic trace into overlapping frames using a sliding time window with a step of one time sample, and consider each frame as a replacement for a single seismic signal. For a 2D seismic gather, we obtain two 2D maps of the ghost parameters. By assuming that these two parameters vary slowly in the t-x domain, we apply a 2D average filter to these maps, to improve their reliability further. Finally, these deghosted outputs are merged to form the final deghosted result. To demonstrate the flexibility of the proposed method for arbitrary variable depths of the receivers, we apply it to several synthetic and field seismic datasets acquired by variable depth streamer.

  8. Catching the fish - Constraining stellar parameters for TX Piscium using spectro-interferometric observations

    NASA Astrophysics Data System (ADS)

    Klotz, D.; Paladini, C.; Hron, J.; Aringer, B.; Sacuto, S.; Marigo, P.; Verhoelst, T.

    2013-02-01

    Context. Stellar parameter determination is a challenging task when dealing with galactic giant stars. The combination of different investigation techniques has proven to be a promising approach. Aims: We analyse archive spectra obtained with the Short Wavelength Spectrometer (SWS) onboard ISO, and new interferometric observations from the Very Large Telescope MID-infrared Interferometric instrument (VLTI/MIDI) of a very well studied carbon-rich giant: TX Psc. The aim of this work is to determine stellar parameters using spectroscopy and interferometry. Methods: The observations are used to constrain the model atmosphere, and eventually the stellar evolutionary model in the region where the tracks map the beginning of the carbon star sequence. Two different approaches are used to determine stellar parameters: (i) the "classic" interferometric approach where the effective temperature is fixed by using the angular diameter in the N-band (from interferometry) and the apparent bolometric magnitude; (ii) parameters are obtained by fitting a grid of state-of-the-art hydrostatic models to spectroscopic and interferometric observations. Results: We find good agreement between the parameters of the two methods. The effective temperature and luminosity clearly place TX Psc in the carbon-rich AGB star domain in the H-R-diagram. Current evolutionary tracks suggest that TX Psc became a C-star just recently, which means that the star is still in a "quiet" phase compared to the subsequent strong-wind regime. This agrees with the C/O ratio being only slightly greater than one. Based on observations made with ESO telescopes at Paranal Observatory under program IDs 74.D-0601, 60.A-9224, 77.C-0440, 60.A-9006, 78.D-0112, 84.D-0805.

  9. Tank 241-TX-104, cores 230 and 231 analytical results for the final report

    SciTech Connect

    Diaz, L.A.

    1998-07-07

    This document is the analytical laboratory report for tank 241-TX-104 push mode core segments collected between February 18, 1998 and February 23, 1998. The segments were subsampled and analyzed in accordance with the Tank 241-TX-104 Push Mode Core Sampling and Analysis Plan (TSAP) (McCain, 1997), the Data Quality Objective to Support Resolution of the Organic Complexant Safety Issue (Organic DQO) (Turner, et al., 1995) and the Safety Screening Data Quality Objective (DQO) (Dukelow, et.al., 1995). The analytical results are included in the data summary table. None of the samples submitted for Differential Scanning Calorimetry (DSC) and Total Alpha Activity (AT) exceeded notification limits as stated in the TSAP. The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems Technical Basis Group in accordance with the Memorandum of Understanding (Schreiber, 1997) and are not considered in this report. Appearance and Sample Handling Attachment 1 is a cross reference to relate the tank farm identification numbers to the 222-S Laboratory LabCore/LIMS sample numbers. The subsamples generated in the laboratory for analyses are identified in these diagrams with their sources shown. Core 230: Three push mode core segments were removed from tank 241-TX-104 riser 9A on February 18, 1998. Segments were received by the 222-S Laboratory on February 19, 1998. Two segments were expected for this core. However, due to poor sample recovery, an additional segment was taken and identified as 2A. Core 231: Four push mode core segments were removed from tank 241-TX-104 riser 13A between February 19, 1998 and February 23, 1998. Segments were received by the 222-S Laboratory on February 24, 1998. Two segments were expected for this core. However, due to poor sample recovery, additional segments were taken and identified as 2A and 2B. The TSAP states the core samples should be transported to the laboratory within three

  10. Chemical Modifications of PhTX-I Myotoxin from Porthidium hyoprora Snake Venom: Effects on Structural, Enzymatic, and Pharmacological Properties

    PubMed Central

    Huancahuire-Vega, Salomón; Corrêa, Daniel H. A.; Hollanda, Luciana M.; Lancellotti, Marcelo; Ramos, Carlos H. I.; Ponce-Soto, Luis Alberto; Marangoni, Sergio

    2013-01-01

    We recently described the isolation of a basic PLA2 (PhTX-I) from Porthidium hyoprora snake venom. This toxin exhibits high catalytic activity, induces in vivo myotoxicity, moderates footpad edema, and causes in vitro neuromuscular blockade. Here, we describe the chemical modifications of specific amino acid residues (His, Tyr, Lys, and Trp), performed in PhTX-I, to study their effects on the structural, enzymatic, and pharmacological properties of this myotoxin. After chemical treatment, a single His, 4 Tyr, 7 Lys, and one Trp residues were modified. The secondary structure of the protein remained unchanged as measured by circular dichroism; however other results indicated the critical role played by Lys and Tyr residues in myotoxic, neurotoxic activities and mainly in the cytotoxicity displayed by PhTX-I. His residue and therefore catalytic activity of PhTX-I are relevant for edematogenic, neurotoxic, and myotoxic effects, but not for its cytotoxic activity. This dissociation observed between enzymatic activity and some pharmacological effects suggests that other molecular regions distinct from the catalytic site may also play a role in the toxic activities exerted by this myotoxin. Our observations supported the hypothesis that both the catalytic sites as the hypothetical pharmacological sites are relevant to the pharmacological profile of PhTX-I. PMID:23484072

  11. Centipede venom peptide SsmTX-I with two intramolecular disulfide bonds shows analgesic activities in animal models.

    PubMed

    Wang, Ying; Li, Xiaojie; Yang, Meifeng; Wu, Chunyun; Zou, Zhirong; Tang, Jing; Yang, Xinwang

    2017-03-01

    Pain is a major symptom of many diseases and results in enormous pressures on human body or society. Currently, clinically used analgesic drugs, including opioids and nonsteroidal anti-inflammatory drugs, have adverse reactions, and thus, the development of new types of analgesic drug candidates is urgently needed. Animal venom peptides have proven to have potential as new types of analgesic medicine. In this research, we describe the isolation and characterization of an analgesic peptide from the crude venom of centipede, Scolopendra subspinipes mutilans. The amino acid sequence of this peptide was identical with SsmTX-I that was previously reported as a specific Kv2.1 ion channel blocker. Our results revealed that SsmTX-I was produced by posttranslational processing of a 73-residue prepropeptide. The intramolecular disulfide bridge motifs of SsmTX-I was Cys1-Cys3 and Cys2-Cys4. Functional assay revealed that SsmTX-I showed potential analgesic activities in formalin-induced paw licking, thermal pain, and acetic acid-induced abdominal writhing mice models. Our research provides the first report of cDNA sequences, disulfide motif, successful synthesis, and analgesic potential of SsmTX-I for the development of pain-killing drugs. It indicates that centipede peptide toxins could be a treasure trove for the search of novel analgesic drug candidates. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

  12. Tank 241-TX-118, core 236 analytical results for the final report

    SciTech Connect

    ESCH, R.A.

    1998-11-19

    This document is the analytical laboratory report for tank 241-TX-118 push mode core segments collected between April 1, 1998 and April 13, 1998. The segments were subsampled and analyzed in accordance with the Tank 241-TX-118 Push Mode Core sampling and Analysis Plan (TSAP) (Benar, 1997), the Safety Screening Data Quality Objective (DQO) (Dukelow, et al., 1995), the Data Quality Objective to Support Resolution of the Organic Complexant Safety Issue (Organic DQO) (Turner, et al, 1995) and the Historical Model Evaluation Data Requirements (Historical DQO) (Sipson, et al., 1995). The analytical results are included in the data summary table (Table 1). None of the samples submitted for Differential Scanning Calorimetry (DSC) and Total Organic Carbon (TOC) exceeded notification limits as stated in the TSAP (Benar, 1997). One sample exceeded the Total Alpha Activity (AT) analysis notification limit of 38.4{micro}Ci/g (based on a bulk density of 1.6), core 236 segment 1 lower half solids (S98T001524). Appropriate notifications were made. Plutonium 239/240 analysis was requested as a secondary analysis. The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems Technical Basis Group in accordance with the Memorandum of Understanding (Schreiber, 1997) and are not considered in this report.

  13. Texture enhanced optimization-based image reconstruction (TxE-OBIR) from sparse projection views

    NASA Astrophysics Data System (ADS)

    Xie, Huiqiao; Niu, Tianye; Yang, Yi; Ren, Yi; Tang, Xiangyang

    2016-03-01

    The optimization-based image reconstruction (OBIR) has been proposed and investigated in recent years to reduce radiation dose in X-ray computed tomography (CT) through acquiring sparse projection views. However, the OBIR usually generates images with a quite different noise texture compared to the clinical widely used reconstruction method (i.e. filtered back-projection - FBP). This may make the radiologists/physicians less confident while they are making clinical decisions. Recognizing the fact that the X-ray photon noise statistics is relatively uniform across the detector cells, which is enabled by beam forming devices (e.g. bowtie filters), we propose and evaluate a novel and practical texture enhancement method in this work. In the texture enhanced optimization-based image reconstruction (TxEOBIR), we first reconstruct a texture image with the FBP algorithm from a full set of synthesized projection views of noise. Then, the TxE-OBIR image is generated by adding the texture image into the OBIR reconstruction. As qualitatively confirmed by visual inspection and quantitatively by noise power spectrum (NPS) evaluation, the proposed method can produce images with textures that are visually identical to those of the gold standard FBP images.

  14. Monte Carlo modeling of a Novalis Tx Varian 6 MV with HD-120 multileaf collimator.

    PubMed

    Vazquez-Quino, Luis Alberto; Massingill, Brian; Shi, Chengyu; Gutierrez, Alonso; Esquivel, Carlos; Eng, Tony; Papanikolaou, Nikos; Stathakis, Sotirios

    2012-09-06

    A Monte Carlo model of the Novalis Tx linear accelerator equipped with high-definition multileaf collimator (HD-120 HD-MLC) was commissioned using ionization chamber measurements in water. All measurements in water were performed using a liquid filled ionization chamber. Film measurements were made using EDR2 film in solid water. Open rectangular fields defined by the jaws or the HD-MLC were used for comparison against measurements. Furthermore, inter- and intraleaf leakage calculated by the Monte Carlo model was compared against film measurements. The statistical uncertainty of the Monte Carlo calculations was less than 1% for all simulations. Results for all regular field sizes show an excellent agreement with commissioning data (percent depth-dose curves and profiles), well within 1% of difference in the relative dose and 1 mm distance to agreement. The computed leakage through HD-MLCs shows good agreement with film measurements. The Monte Carlo model developed in this study accurately represents the new Novalis Tx Varian linac with HD-MLC and can be used for reliable patient dose calculations.

  15. Tank characterization report for single-shell tank 241-TX-104

    SciTech Connect

    FIELD, J.G.

    1999-05-12

    A major function of the Tank Waste Remediation System (TWRS) is to characterize waste in support of waste management and disposal activities at the Hanford Site. Analytical data from sampling and analysis and other available information about a tank are compiled and maintained in a tank characterization report (TCR). This report and its appendices serve as the TCR for single-shell tank 241-TX-104. The objectives of this report are (1) to use characterization data in response to technical issues associated with tank 241-TX-104 waste, and (2) to provide a standard characterization of this waste in terms of a best-basis inventory estimate. Section 2.0 summarizes the response to technical issues, Section 3.0 shows the best-basis inventory estimate, Section 4.0 makes recommendations about the safety status of the tank and additional sampling needs. The appendices contain supporting data and information. This report supports the requirements of the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1997), Milestone M-44-15c, change request M-44-97-03 to ''issue characterization deliverables consistent with the Waste Information Requirements Document developed for FY 1999'' (Adams et al. 1998).

  16. Atomic defects in monolayer titanium carbide (Ti3C2Tx) MXene

    DOE PAGES

    Sang, Xiahan; Xie, Yu; Lin, Ming -Wei; ...

    2016-09-06

    Here, the 2D transition metal carbides or nitrides, or MXenes, are emerging as a group of materials showing great promise in lithium ion batteries and supercapacitors. Until now, characterization and properties of single-layer MXenes have been scarcely reported. Here, using scanning transmission electron microscopy, we determined the atomic structure of freestanding monolayer Ti3C2Tx flakes prepared via the minimally intensive layer delamination method and characterized different point defects that are prevalent in the monolayer flakes. We determine that the Ti vacancy concentration can be controlled by the etchant concentration during preparation. Density function theory-based calculations confirm the defect structures and predictmore » that the defects can influence the surface morphology and termination groups, but do not strongly influence the metallic conductivity. Using devices fabricated from single- and few-layer Ti3C2Tx MXene flakes, the effect of the number of layers in the flake on conductivity has been demonstrated.« less

  17. Characterization of brevetoxin (PbTx-3) exposure in neurons of the anoxia-tolerant freshwater turtle (Trachemys scripta).

    PubMed

    Cocilova, Courtney C; Milton, Sarah L

    2016-11-01

    Harmful algal blooms are increasing in frequency and extent worldwide and occur nearly annually off the west coast of Florida where they affect both humans and wildlife. The dinoflagellate Karenia brevis is a key organism in Florida red tides that produces a suite of potent neurotoxins collectively referred to as the brevetoxins (PbTx). Brevetoxins bind to and open voltage gated sodium channels (VGSC), increasing cell permeability in excitable cells and depolarizing nerve and muscle tissue. Exposed animals may thus show muscular and neurological symptoms including head bobbing, muscle twitching, paralysis, and coma; large HABs can result in significant morbidity and mortality of marine life, including fish, birds, marine mammals, and sea turtles. Brevetoxicosis however is difficult to treat in endangered sea turtles as the physiological impacts have not been investigated and the magnitude and duration of brevetoxin exposure are generally unknown. In this study we used the freshwater turtle Trachemys scripta as a model organism to investigate the effects of the specific brevetoxin PbTx-3 in the turtle brain. Primary turtle neuronal cell cultures were exposed to a range of PbTx-3 concentrations to determine excitotoxicity. Agonists and antagonists of voltage-gated sodium channels and downstream targets were utilized to confirm the toxin's mode of action. We found that turtle neurons are highly resistant to PbTx-3; while cell viability decreased in a dose dependent manner across PbTx-3 concentrations of 100-2000nM, the EC50 was significantly higher than has been reported in mammalian neurons. PbTx-3 exposure resulted in significant Ca(2+) influx, which could be fully abrogated by the VGSC antagonist tetrodotoxin, NMDA receptor blocker MK-801, and tetanus toxin, indicating that the mode of action in turtle neurons is the same as in mammalian cells. As both turtle and mammalian VGSCs have a high affinity for PbTx-3, we suggest that the high resistance of the turtle

  18. Protein Degradation in a TX-TL Cell-free Expression System Using ClpXP Protease

    DTIC Science & Technology

    2014-07-14

    INTRODUCTION An in vitro S30-based Escherichia coli expression system (“Transcription-Translation”, or “TX-TL”) has been developed as an...REFERENCES: 1.! Sun,!Z.Z.,!et!al.,!Protocols(for(Implementing(an( Escherichia ( Coli (Based(TX9TL( Cell9Free(Expression(System(for(Synthetic...protein( degradation(in(an( Escherichia ( coli (cell9free(expression(system.!J!Biol!Eng,!2010.! 4:!p.!9.! 4.! Shin,!J.!and!V.!Noireaux,!Efficient(cell9free

  19. 76 FR 14052 - Notice of Inventory Completion: Sabine River Authority of Texas, Quitman, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... fragments. Dr. Harrell Gill-King, Anthropologist, University of North Texas, performed an examination of the human and non-human remains at the request of the Hunt County Sheriff's Department. Dr....

  20. PhTX-II a Basic Myotoxic Phospholipase A2 from Porthidium hyoprora Snake Venom, Pharmacological Characterization and Amino Acid Sequence by Mass Spectrometry

    PubMed Central

    Huancahuire-Vega, Salomón; Ponce-Soto, Luis Alberto; Marangoni, Sergio

    2014-01-01

    A monomeric basic PLA2 (PhTX-II) of 14149.08 Da molecular weight was purified to homogeneity from Porthidium hyoprora venom. Amino acid sequence by in tandem mass spectrometry revealed that PhTX-II belongs to Asp49 PLA2 enzyme class and displays conserved domains as the catalytic network, Ca2+-binding loop and the hydrophobic channel of access to the catalytic site, reflected in the high catalytic activity displayed by the enzyme. Moreover, PhTX-II PLA2 showed an allosteric behavior and its enzymatic activity was dependent on Ca2+. Examination of PhTX-II PLA2 by CD spectroscopy indicated a high content of alpha-helical structures, similar to the known structure of secreted phospholipase IIA group suggesting a similar folding. PhTX-II PLA2 causes neuromuscular blockade in avian neuromuscular preparations with a significant direct action on skeletal muscle function, as well as, induced local edema and myotoxicity, in mice. The treatment of PhTX-II by BPB resulted in complete loss of their catalytic activity that was accompanied by loss of their edematogenic effect. On the other hand, enzymatic activity of PhTX-II contributes to this neuromuscular blockade and local myotoxicity is dependent not only on enzymatic activity. These results show that PhTX-II is a myotoxic Asp49 PLA2 that contributes with toxic actions caused by P. hyoprora venom. PMID:25365526

  1. A draft whole genome sequence of “Candidatus Liberibacter asiaticus” strain TX2351 from Asian citrus psyllids in Texas, USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The draft genome sequence of “Candidatus Liberibacter asiaticus” strain TX2351 collected from ACP in South Texas has been determined. The TX2351 genome is 1,252,043 bp in size with a 36.5% G+C content, encoding 1,184 predicted open reading frames and 51 RNA genes....

  2. The toxic milk mutation, tx, which results in a condition resembling Wilson disease in humans, is linked to mouse chromosome 8

    SciTech Connect

    Rauch, H.; Wells, A.J.

    1995-09-20

    Litters produced by females homozygous for the toxic milk mutation, tx/tx, display a syndrome that includes poor growth, hypopigmentation, tremors, and death before 2 weeks of age. These features, consistent with copper deficiency, are attributed to failure in fetal hepatic copper accumulation. Here we report the chromosomal linkage of this mutation. 5 refs., 1 tab.

  3. 78 FR 19985 - Modification of VOR Federal Airways V-68, V-76, V-194, and V-548 in the Vicinity of Houston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Modification of VOR Federal Airways V-68, V-76, V-194, and V-548 in the Vicinity of Houston, TX AGENCY: Federal Aviation Administration (FAA... (VOR) Federal airways V-68, V-76, V-194, and V-548 in the vicinity of Houston, TX. The FAA is...

  4. Hancock County Awards Gala

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Gene Goldman (left), deputy director of NASA's John C. Stennis Space Center, accepts an Award of Excellence from Jack Zink, executive director of the Hancock County Port and Harbor Commission, during the 2008 Annual Hancock County Awards Gala. The Award of Excellence was presented to recognize Stennis Space Center's contribution to NASA's 50 years of excellence in space exploration.

  5. The effect of PhTx3 on the release of 3H-acetylcholine induced by tityustoxin and potassium in brain cortical slices and myenteric plexus.

    PubMed

    Gomez, R S; Casali, T A; Romano-Silva, M A; Cordeiro, M N; Diniz, C R; Moraes-Santos, T; Prado, M A; Gomez, M V

    1995-08-18

    The venom of the Brazilian spider Phoneutria nigriventer possesses several neurotoxic polypeptidic fractions. Previous work has established that one of the toxic components, PhTx3, inhibited Ca(2+)-dependent glutamate release and the increase in cytosolic free Ca2+ in response to membrane depolarization. In the present work, we investigated the effect of PhTx3 on the release of acetylcholine (ACh) from brain and peripheral neurons. PhTx3 decreased the release of [3H]-ACh induced by tityustoxin and KCl in brain cortical slices and myenteric plexus. The inhibitory effect of myenteric plexus had the same magnitude as that obtained in the absence of extracellular Ca2+. However, in brain PhTx3 was less efficient at decreasing the evoked release of ACh. These experiments suggest that the target of PhTx3 is coupled to the process of release of ACh in brain and autonomic nervous system.

  6. Cost-effectiveness analysis of TxDOT CNG fleet conversion, volume 1

    NASA Astrophysics Data System (ADS)

    Euritt, M. A.; Taylor, D. B.; Mahmassani, H.

    1992-08-01

    Increased emphasis on energy efficiency and air quality has resulted in a number of state and federal initiatives examining the use of alternative fuels for motor vehicles. A Texas program for alternate fuels includes compressed natural gas (CNG). Based on analysis of 30-year life-cycle costs, development of a natural gas vehicle (NGV) program for the Texas Department of Transportation (TxDOT) would cost about $47 million (in 1991 dollars). These costs include savings from lower-priced natural gas, infrastructure costs for a fast-fueling station, vehicle costs, and operating costs. The 30-year life-cycle costs translate into an average annual vehicle cost increase of $596, or about 4.9 cents more per vehicle mile of travel.

  7. Preliminary tank characterization report for single-shell tank 241-TX-111: Best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-08-26

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-111 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task. The best-basis inventory is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes (Kupfer et al. 1997) describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available.

  8. Preliminary tank characterization report for single-shell tank 241-TX-101: best-basis inventory

    SciTech Connect

    Kupfer, M.J.

    1997-09-02

    This document is a preliminary Tank Characterization Report (TCR). It only contains the current best-basis inventory (Appendix D) for single-shell tank 241-TX-101. No TCRs have been previously issued for this tank, and current core sample analyses are not available. The best-basis inventory, therefore, is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available.

  9. Preliminary tank characterization report for single-shell tank 241-TX-106: Best-basis inventory

    SciTech Connect

    Kupfer, M.J.

    1997-08-26

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-106 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task. The best-basis inventory is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes (Kupfer et al. 1997) describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available.

  10. Preliminary tank characterization report for single-shell tank 241-TX-112: Best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-08-26

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-112 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task. The best-basis inventory is based on an engineering assessment of waste type, process flowsheet data, early sample data, and other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes (Kupfer et al. 1997) describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available.

  11. Preliminary tank characterization report for single-shell tank 241-TX-113: best-basis inventory

    SciTech Connect

    Place, D.E.

    1997-08-26

    This document is a preliminary Tank Characterization Report (TCR). It only contains the current best-basis inventory (Appendix D) for single-shell tank 241-TX-113. No TCRs have been previously issued for this tank, and current core sample analyses are not available. The best-basis inventory, therefore, is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available.

  12. Preliminary tank characterization report for single-shell tank 241-TX-108: best-basis inventory

    SciTech Connect

    Jo, J.

    1997-08-26

    This document is a preliminary Tank Characterization Report (TCR). It only contains the current best-basis inventory (Appendix D) for single-shell tank 241-TX-108. No TCR has been previously issued for this tank, and current core sample analyses are not available. The best-basis inventory, therefore, is based on an engineering assessment of waste type, process flowsheet data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available.

  13. 76 FR 33333 - Use of Small Area Fair Market Rents for Project Base Vouchers in the Dallas TX Metropolitan Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Use of Small Area Fair Market Rents for Project Base Vouchers in the Dallas TX Metropolitan Area AGENCY: Office of the Assistant Secretary for Public and Indian Housing, HUD. ACTION:...

  14. 77 FR 8806 - Foreign-Trade Zone 183-Austin, TX; Application for Reorganization Under the Alternative Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Foreign-Trade Zones Board Foreign-Trade Zone 183--Austin, TX; Application for Reorganization Under the... within the Austin Enterprise Zone, located at Bolm Road and Gardner Road, Austin; Site 2 (50 acres)--Balcones Research site located in north central Austin at the intersection of Burnett Road and...

  15. 77 FR 31308 - Foreign-Trade Zone 36-Galveston, TX; Application for Reorganization/Expansion Under Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Foreign-Trade Zones Board Foreign-Trade Zone 36--Galveston, TX; Application for Reorganization/Expansion...) Board (the Board) by the Board of Trustees of the Galveston Wharves, grantee of FTZ 36, requesting... of Trustees of the Galveston Wharves (Board Order 1080, 65 FR 11548-11549, 3/3/00). The current...

  16. 75 FR 64276 - Reorganization/Expansion of Foreign-Trade Zone 196 Under Alternative Site Framework Fort Worth, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... Framework Fort Worth, TX Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as..., the Board adopted the alternative site framework (ASF) in December 2008 (74 FR 1170, 01/12/09... framework is approved, subject to the FTZ Act and the Board's regulations, including Section 400.28, to...

  17. 78 FR 73109 - Radio Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK... Commission amends the Table of FM Allotments by removing Channel 221C0 at Port Lions, Alaska; Channel 247C3... two or more FM auctions. No bids were entered for these allotments in Auction 94. It is...

  18. RCRA Assessment Plan for Single-Shell Tank Waste Management Area TX-TY at the Hanford Site

    SciTech Connect

    Hodges, Floyd N.; Chou, Charissa J.

    2001-02-23

    A groundwater quality assessment plan was prepared to investigate the rate and extent of aquifer contamination beneath Waste Management Area TX-TY on the Hanford Site in Washington State. This plan is an update of a draft plan issued in February 1999, which guided work performed in fiscal year 2000.

  19. 33 CFR 165.T08-0240 - Safety Zone; Kemah Boardwalk Summer Season Fireworks, Galveston Bay, Kemah, TX.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Summer Season Fireworks, Galveston Bay, Kemah, TX. 165.T08-0240 Section 165.T08-0240 Navigation and... Areas Eighth Coast Guard District § 165.T08-0240 Safety Zone; Kemah Boardwalk Summer Season Fireworks...' radius around a fireworks barge located at approximate Latitude 29°32′57″ N, Longitude 095°00′31″ W....

  20. Dielectric spectroscopy study on ionic liquid microemulsion composed of water, TX-100, and BmimPF6

    NASA Astrophysics Data System (ADS)

    Chen, Zhen; Nozaki, Ryusuke

    2012-06-01

    We report here a broadband dielectric spectroscopy study on an ionic liquid microemulsion (ILM) composed of water, Triton X-100 (TX-100), and 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF6). It is found that the phase behavior of this ILM can be easily identified by its dielectric response. The dielectric behavior of the ILM in the GHz range is consistent with that of TX-100/water mixtures with comparable water-to-TX-100 weight ratio. It consists of the relaxations due to ethylene oxide (EO) unit relaxation, hydration water dynamics, and/or free water dynamics. The water content dependence of the EO unit relaxation suggests that this relaxation involves dynamics of hydration water molecules. In the IL-in-water microemulsion phase, it is found that bmimPF6 molecules are preferentially dissolved in water when their concentration in water is lower than the solubility. An additional dielectric relaxation that is absent in the TX-100/water mixtures is observed in the frequency range of 107-108 Hz for this ILM. This low-frequency relaxation is found closely related to the bmimPF6 molecule and could be attributed to the hopping of its cations/anions between the anionic/cationic sites.

  1. 75 FR 29695 - Security Zones; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ... Guard proposes a 100-foot security zone around LNG carriers while they are moored at the Golden Pass LNG facility in Sabine, TX and/or the Sabine Pass LNG facility located in Cheniere, LA. DATES: Comments and... the Captain of the Port to create fixed security zones around moored LNG carriers and moving...

  2. 75 FR 8741 - Notice of Intent to Repatriate Cultural Items: Stephen F. Austin State University, Nacogdoches, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... National Park Service Notice of Intent to Repatriate Cultural Items: Stephen F. Austin State University... to repatriate cultural items in the control of Stephen F. Austin State University, Nacogdoches, TX... under contract with Stephen F. Austin State University. In 1957, 15 cultural items were removed from...

  3. Draft Genome Sequence of Pseudomonas nitroreducens Strain TX1, Which Degrades Nonionic Surfactants and Estrogen-Like Alkylphenols

    PubMed Central

    Chen, Hsin; Hu, Anyi; Tuan, Nguyen Ngoc

    2014-01-01

    Pseudomonas nitroreducens TX1 ATCC PTA-6168 was isolated from rice field drainage in Taiwan. The bacterium is of special interest because of its capability to use nonionic surfactants (alkylphenol polyethoxylates) and estrogen-like compounds (4-t-octylphenol and 4-nonylphenol) as a sole carbon source. This is the first report on the genome sequence of P. nitroreducens. PMID:24482523

  4. Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea

    PubMed Central

    Razavi, Zahra; Momtaz, Hossein Emad

    2017-01-01

    Chromosomal translocations constitute one of the most important, yet uncommon, causes of primary amenorrhea and gonadal dysgenesis. Although X-autosome translocations are frequently associated with streak gonads and clinical features of the Turner syndrome, the majority of X-autosome carriers may present with a variable phenotype, developmental delay, and recognizable X-linked syndrome due to nonrandom X-inactivation. In this article, we describe a healthy 15.5-year-old girl with primary amenorrhea, gonadal dysgenesis, and tall stature without other manifestations of the Turner syndrome. Relevant clinical, biochemical, endocrinological, and cytogenetical evaluations were performed. Initial investigations revealed hypergonadotropic hypogonadism (FSH=134 mIU/mL [normal=10–15 mIU/mL], LH=47.5 [normal=10–15 mIU/mL], and estradiol=24.3 pmol/L). On ultrasound examination of the pelvis, streak ovaries with a hypoplastic uterus were noted. Chromosome study, performed according to routine procedures, revealed an apparently balanced reciprocal translocation involving the short arm of chromosome 1(p2) and the long arm of the X chromosome (q2) in all the cells with the following karyotype: 46,X,t(1;X)(p13;q22). She was placed on hormone replacement therapy. In our patient, X-autosome translocation was associated with gonadal dysgenesis and tall stature. We conclude that t(X;1) may be associated with gonadal dysgenesis without other congenital abnormalities. To our knowledge, normal phenotype with gonadal dysgenesis and tall stature in association with t(X;1) translocation has not been previously reported. PMID:28360449

  5. High-Capacitance Mechanism for Ti3C2Tx MXene by in Situ Electrochemical Raman Spectroscopy Investigation.

    PubMed

    Hu, Minmin; Li, Zhaojin; Hu, Tao; Zhu, Shihao; Zhang, Chao; Wang, Xiaohui

    2016-12-27

    MXenes represent an emerging family of conductive two-dimensional materials. Their representative, Ti3C2Tx, has been recognized as an outstanding member in the field of electrochemical energy storage. However, an in-depth understanding of fundamental processes responsible for the superior capacitance of Ti3C2Tx MXene in acidic electrolytes is lacking. Here, to understand the mechanism of capacitance in Ti3C2Tx MXene, we studied electrochemically the charge/discharge processes of Ti3C2Tx electrodes in sulfate ion-containing aqueous electrolytes with three different cations, coupled with in situ Raman spectroscopy. It is demonstrated that hydronium in the H2SO4 electrolyte bonds with the terminal O in the negative electrode upon discharging while debonding occurs upon charging. Correspondingly, the reversible bonding/debonding changes the valence state of Ti element in the MXene, giving rise to the pseudocapacitance in the acidic electrolyte. In stark contrast, only electric double layer capacitance is recognized in the other electrolytes of (NH4)2SO4 or MgSO4. The charge storage ways also differ: ion exchange dominates in H2SO4, while counterion adsorption in the rest. Hydronium that is characterized by smaller hydration radius and less charge is the most mobile among the three cations, facilitating it more kinetically accommodated on the deep adsorption sites between the MXene layers. The two key factors, i.e., surface functional group-involved bonding/debonding-induced pseudocapacitance, and ion exchange-featured charge storage, simultaneously contribute to the superior capacitance of Ti3C2Tx MXene in acidic electrolytes.

  6. 75 FR 36348 - Opportunity for Designation in the Amarillo, TX; Cairo, IL; and State of North Carolina Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... Donley County; the southern Donley and Armstrong County lines west to Prairie Dog Town Fork of the Red River; Prairie Dog Town Fork of the Red River northwest to State Route 217; State Route 217 west to...

  7. Garrett County Aids AID

    ERIC Educational Resources Information Center

    Appalachia, 1975

    1975-01-01

    Garrett County, Maryland volunteered to act as a pre-overseas learning laboratory for AID (Agency for International Development) interns who practiced data collection and planning techniques with the help of local citizenry. (JC)

  8. Nitric Oxide-Induced Vasorelaxation in Response to PnTx2-6 Toxin from Phoneutria nigriventer Spider in Rat Cavernosal Tissue

    PubMed Central

    Nunes, Kenia P.; Cordeiro, Marta N.; Richardson, Michael; Borges, Marcia N.; Diniz, Simone O.F.; Cardoso, Valbert N.; Tostes, Rita; De Lima, Maria Elena; Webb, Robert Clinton; Leite, Romulo

    2011-01-01

    Introduction Priapism is one of several symptoms observed in accidental bites by the spider Phoneutria nigriventer. The venom of this spider is comprised of many toxins, and the majority has been shown to affect excitable ion channels, mainly sodium (Na+) channels. It has been demonstrated that PnTx2-6, a peptide extracted from the venom of P. nigriventer, causes erection in anesthetized rats and mice. Aim We investigated the mechanism by which PnTx2-6 evokes relaxation in rat corpus cavernosum. Main Outcome Measures PnTx2-6 toxin potentiates nitric oxide (NO)-dependent cavernosal relaxation. Methods Rat cavernosal strips were incubated with bretylium (3 × 10−5 M) and contracted with phenylephrine (PE; 10−5 M). Relaxation responses were evoked by electrical field stimulation (EFS) or sodium nitroprusside (SNP) before and after 4 minutes of incubation with PnTx2-6 (10−8 M). The effect of PnTx2-6 on relaxation induced by EFS was also tested in the presence of atropine (10−6 M), a muscarinic receptor antagonist, N-type Ca2+ channel blockers (ω-conotoxin GVIA, 10−6 M) and sildenafil (3 × 10−8 M). Technetium99m radiolabeled PnTx2-6 subcutaneous injection was administrated in the penis. Results Whereas relaxation induced by SNP was not affected by PnTx2-6, EFS-induced relaxation was significantly potentiated by this toxin as well as PnTx2-6 plus SNP. This potentiating effect was further increased by sildenafil, not altered by atropine, however was completely blocked by the N-type Ca2+ channels. High concentrated levels of radiolabeled PnTx2-6 was specifically found in the cavernosum tissue, suggesting PnTx2-6 is an important toxin responsible for P. nigriventer spider accident-induced priapism. Conclusion We show that PnTx2-6 slows Na+ channels inactivation in nitrergic neurons, allowing Ca2+ influx to facilitate NO/cGMP signalling, which promotes increased NO production. In addition, this relaxation effect is independent of phosphodiesterase enzyme type 5

  9. The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1{alpha} targeted gene expression

    SciTech Connect

    Miyake, Kotaro; Nishioka, Masanori; Imura, Satoru; Batmunkh, Erdenebulgan; Uto, Yoshihiro; Nagasawa, Hideko; Hori, Hitoshi; Shimada, Mitsuo

    2012-08-01

    Tumor hypoxia has been considered to be a potential therapeutic target, because hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. In the present study, we investigated the antitumor effect of a novel hypoxic cytotoxin, 3-[2-hydroxyethyl(methyl)amino]-2-quinoxalinecarbonitrile 1,4-dioxide (TX-2098) in inhibiting the expression of hypoxia inducible factor-1{alpha} (HIF-1{alpha}), and consequently vascular endothelial cell growth factor (VEGF) expression in pancreatic cancer. The antitumor effects of TX-2098 under hypoxia were tested against various human pancreatic cancer cell lines using WST-8 assay. VEGF protein induced pancreatic cancer was determined on cell-free supernatant by ELISA. Moreover, nude mice bearing subcutaneously (s.c.) or orthotopically implanted human SUIT-2 were treated with TX-2098. Tumor volume, survival and expression of HIF-1 and associated molecules were evaluated in treatment versus control groups. In vitro, TX-2098 inhibited the proliferation of various pancreatic cancer cell lines. In s.c model, tumors from nude mice injected with pancreatic cancer cells and treated with TX-2098 showed significant reductions in volume (P < 0.01 versus control). Quantitative real-time reverse transcription-PCR analysis revealed that TX-2098 significantly inhibited mRNA expression of the HIF-1 associated molecules, VEGF, glucose transporter 1 and Aldolase A (P < 0.01 versus control). These treatments also prolong the survival in orthotopic models. These results suggest that the effect of TX-2098 in pancreatic cancer might be correlated with the expression of VEGF and HIF-1 targeted molecules. -- Highlights: Black-Right-Pointing-Pointer We designed and synthesized novel hypoxic cytoxin, TX-2098. Black-Right-Pointing-Pointer TX-2098 inhibited the proliferation of human pancreatic cancer cells than TPZ. Black-Right-Pointing-Pointer TX-2098 reduced VEGF protein level than TPZ. Black-Right-Pointing-Pointer TX-2098

  10. TX model: a quantitative heat-loss analysis of district heating pipes by means of IR surface-temperature measurements

    NASA Astrophysics Data System (ADS)

    Zinko, Heimo; Perers, Bengt

    1995-03-01

    The aim of this study is to investigate the possibility of analyzing the temperature profile at the ground surface above buried district heating pipes in such a way that enables the quantitative determination of heat loss from the pair of pipes. In practical applications, it is supposed that this temperature profile is generated by means of thermography. For this purpose, the principle of the TX-model has been developed, implementing that the heat losses from pipes buried in the ground has a temperature signature on the ground surface. A qualitative analysis of this temperature signature is very well known and in practical use for detecting leaks from pipes. These techniques mostly makes use of relative changes of the temperature pattern along the pipe. In the quantitative heat loss analysis, however, it is presumed that the temperature profile across the pipes is related to the pipe heat loss in Watt/m. The basic idea is that the integral of the temperature variation across the pipe, called TX, is a function of the heat loss, but affected by some other parameters such as depth, heat diffusivity and so on. In order to analyze the parameters influencing the TX-factor, a simulation model for the energy balance at the ground surface has been developed. This model includes the heat flow from the pipe to the surface and the heat exchange at the surface with the environment due to convection, latent heat change, solar and long wave radiation. The simulation gives the surprising result that the TX factor is relatively unaffected during the course of a day even when the sun is shining, as long as other climate conditions are relatively stable (low wind, no rain, no shadows). The results from the simulations were verified at a testfield in Studsvik, Sweden, with electrically controlled pipe heat losses and long term monitoring of the surface temperature profile and TX factor with temperature sensors at the ground surface. The quantitative TX model for heat loss

  11. Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro

    SciTech Connect

    Cecchini, Alessandra L.; Vasconcelos, Flavio; Giglio, Jose Roberto; Arantes, Eliane Candiani . E-mail: ecabraga@fcfrp.usp.br

    2006-12-01

    Scorpion neurotoxins targeting the Na{sub v} channel can be classified into two classes: {alpha}- and {beta}-neurotoxins and are reported as highly active in mammalian brain. In this work, we evaluate the effects of Tityus serrulatus venom (Ts venom) and its {alpha}-neurotoxin TsTX-V on {gamma}-aminobutyric acid (GABA), dopamine (DA) and glutamate (Glu) uptake in isolated rat brain synaptosomes. TsTX-V was isolated from Ts venom by ion exchange chromatography followed by reverse-phase (C18) high-performance liquid chromatography. Neither Ts venom nor TsTX-V was able to affect {sup 3}H-Glu uptake. On the other hand, Ts venom (0.13 {mu}g/mg) significantly inhibited both {sup 3}H-GABA and {sup 3}H-DA uptake ({approx} 50%). TsTX-V showed IC{sub 5} values of 9.37 {mu}M and 22.2 {mu}M for the inhibition of {sup 3}H-GABA and {sup 3}H-DA uptake, respectively. These effects were abolished by pre-treatment with tetrodotoxin (TTX, 1 {mu}M), indicating the involvement of voltage-gated Na{sup +} channels in this process. In the absence of Ca{sup 2+}, and at low Ts venom concentrations, the reduction of {sup 3}H-GABA uptake was not as marked as in the presence of Ca{sup 2+}. TsTX-V did not reduce {sup 3}H-GABA uptake in COS-7 cells expressing the GABA transporters GAT-1 and GAT-3, suggesting that this toxin indirectly reduces the transport. The reduced {sup 3}H-GABA uptake by synaptosomes might be due to rapid cell depolarization as revealed by confocal microscopy of C6 glioma cells. Thus, TsTX-V causes a reduction of {sup 3}H-GABA and {sup 3}H-DA uptake in a Ca{sup 2+}-dependent manner, not directly affecting GABA transporters, but, in consequence of depolarization, involving voltage-gated Na{sup +} channels.

  12. Evaluation of integrated respiratory gating systems on a Novalis Tx system.

    PubMed

    Chang, Zheng; Liu, Tonghai; Cai, Jing; Chen, Qing; Wang, Zhiheng; Yin, Fang-Fang

    2011-04-04

    The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Position Management (RPM) system, and BrainLAB ExacTrac gating systems. In this study, the two systems were assessed on accuracy of both motion tracking and radiation delivery control. To evaluate motion tracking, two artificial motion profiles and five patients' respiratory profiles were used. The motion trajectories acquired by the two gating systems were compared against the references. To assess radiation delivery control, time delays were measured using a single-exposure method. More specifically, radiation is delivered with a 4 mm diameter cone within the phase range of 10%-45% for the BrainLAB ExacTrac system, and within the phase range of 0%-25% for the Varian RPM system during expiration, each for three times. Radiochromic films were used to record the radiation exposures and to calculate the time delays. In the work, the discrepancies were quantified using the parameters of mean and standard deviation (SD). Pearson's product-moment correlational analysis was used to test correlation of the data, which is quantified using a parameter of r. The trajectory profiles acquired by the gating systems show good agreement with those reference profiles. A quantitative analysis shows that the average mean discrepancies between BrainLAB ExacTrac system and known references are 1.5 mm and 1.9 mm for artificial and patient profiles, with the maximum motion amplitude of 28.0 mm. As for the Varian RPM system, the corresponding average mean discrepancies are 1.1 mm and 1.7 mm for artificial and patient profiles. With the proposed single-exposure method, the time delays are found to be 0.20 ± 0.03 seconds and 0.09 ± 0.01 seconds for BrainLAB ExacTrac and Varian RPM systems, respectively. The results indicate the systems can

  13. The complex environment of the bright carbon star TX Piscium as probed by spectro-astrometry

    NASA Astrophysics Data System (ADS)

    Hron, J.; Uttenthaler, S.; Aringer, B.; Klotz, D.; Lebzelter, T.; Paladini, C.; Wiedemann, G.

    2015-12-01

    Context. Stars on the asymptotic giant branch (AGB) show broad evidence of inhomogeneous atmospheres and circumstellar envelopes. These have been studied by a variety of methods on various angular scales. In this paper we explore the envelope of the well-studied carbon star TX Psc by the technique of spectro-astrometry. Aims: We explore the potential of this method for detecting asymmetries around AGB stars. Methods: We obtained CRIRES observations of several CO Δv = 1 lines near 4.6 μm and HCN lines near 3 μm in 2010 and 2013. These were then searched for spectro-astrometric signatures. For the interpretation of the results, we used simple simulated observations. Results: Several lines show significant photocentre shifts with a clear dependence on position angle. In all cases, tilde-shaped signatures are found where the positive and negative shifts (at PA 0°) are associated with blue and weaker red components of the lines. The shifts can be modelled with a bright blob 70 mas to 210 mas south of the star with a flux of several percent of the photospheric flux. We estimate a lower limit of the blob temperature of 1000 K. The blob may be related to a mass ejection as found for AGB stars or red supergiants. We also consider the scenario of a companion object. Conclusions: Although there is clear spectro-astrometric evidence of a rather prominent structure near TX Psc, it does not seem to relate to the other evidence of asymmetries, so no definite explanation can be given. Our data thus underline the very complex structure of the environment of this star, but further observations that sample the angular scales out to a few hundred milli-arcseconds are needed to get a clearer picture. Based on observations made with ESO telescopes at La Silla Paranal Observatory under programme IDs 386.D-0091 and 091.D-0094.Appendix A is available in electronic form at http://www.aanda.org

  14. Rapidly characterizing the fast dynamics of RNA genetic circuitry with cell-free transcription-translation (TX-TL) systems.

    PubMed

    Takahashi, Melissa K; Chappell, James; Hayes, Clarmyra A; Sun, Zachary Z; Kim, Jongmin; Singhal, Vipul; Spring, Kevin J; Al-Khabouri, Shaima; Fall, Christopher P; Noireaux, Vincent; Murray, Richard M; Lucks, Julius B

    2015-05-15

    RNA regulators are emerging as powerful tools to engineer synthetic genetic networks or rewire existing ones. A potential strength of RNA networks is that they may be able to propagate signals on time scales that are set by the fast degradation rates of RNAs. However, a current bottleneck to verifying this potential is the slow design-build-test cycle of evaluating these networks in vivo. Here, we adapt an Escherichia coli-based cell-free transcription-translation (TX-TL) system for rapidly prototyping RNA networks. We used this system to measure the response time of an RNA transcription cascade to be approximately five minutes per step of the cascade. We also show that this response time can be adjusted with temperature and regulator threshold tuning. Finally, we use TX-TL to prototype a new RNA network, an RNA single input module, and show that this network temporally stages the expression of two genes in vivo.

  15. Rapidly Characterizing the Fast Dynamics of RNA Genetic Circuitry with Cell-Free Transcription–Translation (TX-TL) Systems

    PubMed Central

    2014-01-01

    RNA regulators are emerging as powerful tools to engineer synthetic genetic networks or rewire existing ones. A potential strength of RNA networks is that they may be able to propagate signals on time scales that are set by the fast degradation rates of RNAs. However, a current bottleneck to verifying this potential is the slow design-build-test cycle of evaluating these networks in vivo. Here, we adapt an Escherichia coli-based cell-free transcription-translation (TX-TL) system for rapidly prototyping RNA networks. We used this system to measure the response time of an RNA transcription cascade to be approximately five minutes per step of the cascade. We also show that this response time can be adjusted with temperature and regulator threshold tuning. Finally, we use TX-TL to prototype a new RNA network, an RNA single input module, and show that this network temporally stages the expression of two genes in vivo. PMID:24621257

  16. Photoinduced electron and energy transfer from coumarin 153 to perylenetetracarboxylic diimide in bmimPF6/TX-100/water microemulsions.

    PubMed

    Wu, Haixia; Wang, Haixia; Xue, Lin; Li, Xiyou

    2011-01-15

    A perylenetetracarboxylic diimide (PDI) compound with an attached hydrophilic polyoxyethylene group at the imide nitrogen position was designed and synthesized. Photoinduced electron and energy transfer between coumarin 153 (C-153) and PDI in a ternary microemulsion with an ionic liquid (bmimPF(6)/TX-100/H(2)O) were investigated by steady state electronic absorption and fluorescence spectroscopy. The results revealed that both PDI and C-153 resided at the interface between the surfactant TX-100 and the ionic liquid bmimPF(6) in the ternary microemulsions. The absorption spectra suggested no interactions between C-153 and PDI in the ground states, but the fluorescence spectra revealed the presence of an efficient electron transfer and a less efficient energy transfer from C-153 to PDI. Moreover, the electron transfer was much more efficient in microemulsions than that in homogeneous conventional organic solvents due to the unique micro-environment of the microemulsion.

  17. Reservoir fracture mapping using microearthquakes: Austin chalk, Giddings field, TX and 76 field, Clinton Co., KY

    SciTech Connect

    Phillips, W.S.; Rutledge, J.T.; Fairbanks, T.D.

    1996-12-31

    Patterns of microearthquakes detected downhole defined fracture orientation and extent in the Austin chalk, Giddings field, TX and the 76 field, Clinton Co., KY. We collected over 480 and 770 microearthquakes during hydraulic stimulation at two sites in the Austin chalk, and over 3200 during primary production in Clinton Co. Data were of high enough quality that 20%, 31% and 53% of the events could be located, respectively. Reflected waves constrained microearthquakes to the stimulated depths at the base of the Austin chalk. In plan view, microearthquakes defined elongate fracture zones extending from the stimulation wells parallel to the regional fracture trend. However, widths of the stimulated zones differed by a factor of live between the two Austin chalk sites, indicating a large difference in the population of ancillary fractures. Post-stimulation production was much higher from the wider zone. At Clinton Co., microearthquakes defined low-angle, reverse-fault fracture zones above and below a producing zone. Associations with depleted production intervals indicated the mapped fractures had been previously drained. Drilling showed that the fractures currently contain brine. The seismic behavior was consistent with poroelastic models that predicted slight increases in compressive stress above and below the drained volume.

  18. Reservoir fracture mapping using microearthquakes: Austin chalk, Giddings field, TX and 76 field, Clinton Co., KY

    SciTech Connect

    Phillips, W.S.; Rutledge, J.T.; Gardner, T.L.; Fairbanks, T.D.; Miller, M.E.; Schuessler, B.K.

    1996-11-01

    Patterns of microearthquakes detected downhole defined fracture orientation and extent in the Austin chalk, Giddings field, TX and the 76 field, Clinton Co., KY. We collected over 480 and 770 microearthquakes during hydraulic stimulation at two sites in the Austin chalk, and over 3200 during primary production in Clinton Co. Data were of high enough quality that 20%, 31% and 53% of the events could be located, respectively. Reflected waves constrained microearthquakes to the stimulated depths at the base of the Austin chalk. In plan view, microearthquakes defined elongate fracture zones extending from the stimulation wells parallel to the regional fracture trend. However, widths of the stimulated zones differed by a factor of five between the two Austin chalk sites, indicating a large difference in the population of ancillary fractures. Post-stimulation production was much higher from the wider zone. At Clinton Co., microearthquakes defined low-angle, reverse-fault fracture zones above and below a producing zone. Associations with depleted production intervals indicated the mapped fractures had been previously drained. Drilling showed that the fractures currently contain brine. The seismic behavior was consistent with poroelastic models that predicted slight increases in compressive stress above and below the drained volume.

  19. Nanoscale elastic changes in 2D Ti3C2Tx (MXene) pseudocapacitive electrodes

    DOE PAGES

    Come, Jeremy; Xie, Yu; Naguib, Michael; ...

    2016-02-01

    Designing sustainable electrodes for next generation energy storage devices relies on the understanding of their fundamental properties at the nanoscale, including the comprehension of ions insertion into the electrode and their interactions with the active material. One consequence of ion storage is the change in the electrode volume resulting in mechanical strain and stress that can strongly affect the cycle life. Therefore, it is important to understand the changes of dimensions and mechanical properties occurring during electrochemical reactions. While the characterization of mechanical properties via macroscopic measurements is well documented, in-situ characterization of their evolution has never been achieved atmore » the nanoscale. Two dimensional (2D) carbides, known as MXenes, are promising materials for supercapacitors and various kinds of batteries, and understating the coupling between their mechanical and electrochemical properties is therefore necessary. Here we report on in-situ imaging, combined with density functional theory of the elastic changes, of a 2D titanium carbide (Ti3C2Tx) electrode in direction normal to the basal plane during cation intercalation. The results show a strong correlation between the Li+ ions content and the elastic modulus, whereas little effects of K+ ions are observed. Moreover, this strategy enables identifying the preferential intercalation pathways within a single particle.« less

  20. Protocols for implementing an Escherichia coli based TX-TL cell-free expression system for synthetic biology.

    PubMed

    Sun, Zachary Z; Hayes, Clarmyra A; Shin, Jonghyeon; Caschera, Filippo; Murray, Richard M; Noireaux, Vincent

    2013-09-16

    Ideal cell-free expression systems can theoretically emulate an in vivo cellular environment in a controlled in vitro platform. This is useful for expressing proteins and genetic circuits in a controlled manner as well as for providing a prototyping environment for synthetic biology. To achieve the latter goal, cell-free expression systems that preserve endogenous Escherichia coli transcription-translation mechanisms are able to more accurately reflect in vivo cellular dynamics than those based on T7 RNA polymerase transcription. We describe the preparation and execution of an efficient endogenous E. coli based transcription-translation (TX-TL) cell-free expression system that can produce equivalent amounts of protein as T7-based systems at a 98% cost reduction to similar commercial systems. The preparation of buffers and crude cell extract are described, as well as the execution of a three tube TX-TL reaction. The entire protocol takes five days to prepare and yields enough material for up to 3000 single reactions in one preparation. Once prepared, each reaction takes under 8 hr from setup to data collection and analysis. Mechanisms of regulation and transcription exogenous to E. coli, such as lac/tet repressors and T7 RNA polymerase, can be supplemented. Endogenous properties, such as mRNA and DNA degradation rates, can also be adjusted. The TX-TL cell-free expression system has been demonstrated for large-scale circuit assembly, exploring biological phenomena, and expression of proteins under both T7- and endogenous promoters. Accompanying mathematical models are available. The resulting system has unique applications in synthetic biology as a prototyping environment, or "TX-TL biomolecular breadboard."

  1. Biochemical, Pharmacological, and Structural Characterization of New Basic PLA2 Bbil-TX from Bothriopsis bilineata Snake Venom

    PubMed Central

    Corasolla Carregari, Victor; Stuani Floriano, Rafael; Rodrigues-Simioni, Lea; Winck, Flavia V.; Baldasso, Paulo Aparecido; Ponce-Soto, Luis Alberto; Marangoni, Sergio

    2013-01-01

    Bbil-TX, a PLA2, was purified from Bothriopsis bilineata snake venom after only one chromatographic step using RP-HPLC on μ-Bondapak C-18 column. A molecular mass of 14243.8 Da was confirmed by Q-Tof Ultima API ESI/MS (TOF MS mode) mass spectrometry. The partial protein sequence obtained was then submitted to BLASTp, with the search restricted to PLA2 from snakes and shows high identity values when compared to other PLA2s. PLA2 activity was presented in the presence of a synthetic substrate and showed a minimum sigmoidal behavior, reaching its maximal activity at pH 8.0 and 25–37°C. Maximum PLA2 activity required Ca2+ and in the presence of Cd2+, Zn2+, Mn2+, and Mg2+ it was reduced in the presence or absence of Ca2+. Crotapotin from Crotalus durissus cascavella rattlesnake venom and antihemorrhagic factor DA2-II from Didelphis albiventris opossum sera under optimal conditions significantly inhibit the enzymatic activity. Bbil-TX induces myonecrosis in mice. The fraction does not show a significant cytotoxic activity in myotubes and myoblasts (C2C12). The inflammatory events induced in the serum of mice by Bbil-TX isolated from Bothriopsis bilineata snake venom were investigated. An increase in vascular permeability and in the levels of TNF-a, IL-6, and IL-1 was was induced. Since Bbil-TX exerts a stronger proinflammatory effect, the phospholipid hydrolysis may be relevant for these phenomena. PMID:23509754

  2. The Close Environment of the C-star TX Psc as Seen with CRIRES Spectro-Astrometry

    NASA Astrophysics Data System (ADS)

    Hron, J.; Lebzelter, T.; Paladini, C.; Uttenthaler, S.; Aringer, B.; Wiedemann, G.

    2015-08-01

    We present CRIRES observations of the "normal" carbon star TX Psc in the K, L and M bands, taken in 2010 and 2013. The spectro-astrometry shows clear signatures for the presence of a bright blob south of the star and several photospheric radii away. The flux ratio between blob and star is between 5% and 10%. This blob also shows up as an additional absorption component in the red wings of the CO lines.

  3. Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus.

    PubMed

    Somera, K C; Jones, H C

    2004-03-01

    The H-Tx rat has fetal-onset hydrocephalus associated with closure of the cerebral aqueduct and a reduction in the secretory cells of the subcommissural organ (SCO), a circumventricular organ situated in the dorsal wall of the cerebral aqueduct. The objective of this study was to determine the role of the SCO in hydrocephalus pathogenesis. Serial brain sections through aqueduct regions containing the SCO from H-Tx rats, together with non-hydrocephalic Fischer F344 rats, were studied at E16, before hydrocephalus onset, at E17, the beginning of onset, and at P0 when the hydrocephalus was overt. Tissues were immunostained by AFRU, an antibody against the SCO glycoprotein, and for the intermediate filament nestin. The area of SCO cells with AFRU immunostaining and the severity of lateral ventricle dilatation were quantified by image analysis. At E16 all fetuses had distinct SCO ependymal cells, open aqueducts and normal lateral ventricles. The H-Tx fetuses fell into two groups with large areas and small areas of AFRU immunoreactivity, all with a full complement of SCO cells. By E17, fetuses with small areas of immunoreactivity had reduced numbers of tall SCO secretory cells, and most had aqueducts closed posteriorly and dilated ventricles. Three additional fetuses with small areas of immunoreactivity had narrow but patent aqueducts and normal ventricles, and another had an open aqueduct and dilated ventricles. At P0, pups previously identified as hydrocephalic had small areas of AFRU immunoreactivity, an aqueduct that was closed anteriorly but open posteriorly, ventricular dilatation, and an absence of SCO secretory cells. The aqueduct even when closed was lined by typical ependymal cells throughout. Decreased nestin immunostaining accompanied the SCO changes. It is concluded that reduced SCO glycoprotein immunoreactivity precedes both aqueduct closure and expansion of the lateral ventricles in the H-Tx rat.

  4. 75 FR 52924 - Designation for the Amarillo, TX; Cairo, IL; State of Louisiana; State of North Carolina; Belmond...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... information regarding the designation criteria in section 7(f)(l) of the USGSA (7 U.S.C. 79(f)) and determined... Headquarters location and telephone start end Amarillo Amarillo, TX (806-372-2152)........ 10/1/2010 9/30/2013 Additional Location: Guymon, OK.... Cairo Cairo, IL (618-734-1316) 10/1/2010 9/30/2013 Louisiana Baton...

  5. 77 FR 48960 - Foreign-Trade Zone 12-McAllen, TX Notification of Proposed Export Production Activity TST NA Trim...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... Activity TST NA Trim, LLC (Fabric/Leather Lamination and Cutting) Hidalgo, TX The McAllen Foreign Trade... TST NA Trim, LLC (TST), located in Hidalgo, Texas. The notification conforming to the requirements...

  6. Structural studies of 1-butyl-3-methylimidazolium tetrafluoroborate/TX-100/ p-xylene ionic liquid microemulsions.

    PubMed

    Gao, Yan'an; Zhang, Jin; Xu, Hongyan; Zhao, Xueyan; Zheng, Liqiang; Li, Xinwei; Yu, Li

    2006-07-17

    The ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate (bmimBF4) forms nonaqueous microemulsions with p-xylene, with the aid of the nonionic surfactant TX-100. The phase behavior of the ternary system is investigated, and three microregions of the microemulsions-ionic liquid-in-oil (IL/O), bicontinuous, and oil-in-ionic liquid (O/IL)-are identified by conductivity measurements, according to percolation theory. On the basis of a phase diagram, a series of IL/O microemulsions are chosen and characterized by dynamic light scattering (DLS). The size of aggregates increases on increasing the amount of added polar component (bmimBF(4)), which is a similar phenomenon to that observed for typical water-in-oil (W/O) microemulsions, suggesting the formation of IL/O microemulsions. The microstructural characteristics of the microemulsions are investigated by FTIR and 1H NMR spectroscopy. The results indicate that the interaction between the electronegative oxygen atoms of the oxyethylene (OE) units in TX-100 and the electropositive imidazolium ring may be the driving force for the solubilization of bmimBF4 into the core of the TX-100 aggregates. In addition, the micropolarity of the microemulsions is investigated by using methyl orange (MO) as a UV/Vis spectroscopic probe. A relatively constant polarity of the microemulsion droplets is obtained in the IL microemulsion. Finally, a plausible structure for the IL/O microemulsion is presented.

  7. Electrochemical and optical study of carotenoids in TX 100 micelles: Electron transfer and a large blue shift

    SciTech Connect

    He, Z.; Kispert, L.D.

    1999-10-21

    The first oxidation waves of 8{prime}-apo-{beta}-caroten-8{prime}-al (I) and 8{prime}-apo-{beta}-caroten-8{prime}nitrile (II) in TX100 micelles are clearly observed in their cyclic voltammograms (CVs). The CV of {beta}-carotene (III) in TX100 micelles shows that III is not oxidized. It is proposed that the hydrophobic barrier of the micelle is an important reason for the failure to oxidize III, which is totally located in the hydrophobic center of the micelle. The oxidation of I and II demonstrates that electrons can be transferred through the terminal groups over a distance of ca. 22 {angstrom}. An unusually large blue band shift (100 nm, relative to that in CH{sub 2}Cl{sub 2}) is observed in the optical absorption spectrum of 7{prime}-apo-7{prime},7{prime}-dicyano-{beta}-carotene (IV) in TX100 micelles. This phenomenon is not observed in the absorption spectra of other studied carotenoids. A change in the ground-state electronic structure of IV, due to the influence of water near the terminal dicyanomethylidene group, is proposed to be the major reason for this large band shift.

  8. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

    NASA Astrophysics Data System (ADS)

    Rashid, M. Harunur; Huq, Redwan; Tanner, Mark R.; Chhabra, Sandeep; Khoo, Keith K.; Estrada, Rosendo; Dhawan, Vikas; Chauhan, Satendra; Pennington, Michael W.; Beeton, Christine; Kuyucak, Serdar; Norton, Raymond S.

    2014-03-01

    HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 analogues with an Ala, Phe, Val or Abu substitution at position 14. Complexes of HsTX1 with the voltage-gated potassium channels Kv1.3 and Kv1.1 were created using docking and molecular dynamics simulations, then umbrella sampling simulations were performed to construct the potential of mean force (PMF) of the ligand and calculate the corresponding binding free energy for the most stable configuration. The PMF method predicted that the R14A mutation in HsTX1 would yield a > 2 kcal/mol gain for the Kv1.3/Kv1.1 selectivity free energy relative to the wild-type peptide. Functional assays confirmed the predicted selectivity gain for HsTX1[R14A] and HsTX1[R14Abu], with an affinity for Kv1.3 in the low picomolar range and a selectivity of more than 2,000-fold for Kv1.3 over Kv1.1. This remarkable potency and selectivity for Kv1.3, which is significantly up-regulated in activated effector memory cells in humans, suggest that these analogues represent valuable leads in the development of therapeutics for autoimmune diseases.

  9. Environmental Assessment for North Central Texas Relay Node Site NO. RN8C915TX

    DTIC Science & Technology

    1993-02-11

    River drainage basins (Davenport, 1990). The central and southern portions of the SSA drain southward into the Brazos River (Jones, 1990; Sims, 1989...guy anchors and to prevent inadvertent exposure to electric shock resulting from the buildup of static electric charge. In addition to the main tower...area in Knox and Baylor counties centered 3.6 miles south of the town of Vera, in the Southern Great Plains portion of the Central Lowlands

  10. Clinical commissioning and use of the Novalis Tx linear accelerator for SRS and SBRT.

    PubMed

    Kim, Jinkoo; Wen, Ning; Jin, Jian-Yue; Walls, Nicole; Kim, Sangroh; Li, Haisen; Ren, Lei; Huang, Yimei; Doemer, Anthony; Faber, Kathleen; Kunkel, Tina; Balawi, Ahssan; Garbarino, Kimberly; Levin, Kenneth; Patel, Samir; Ajlouni, Munther; Miller, Brett; Nurushev, Teamor; Huntzinger, Calvin; Schulz, Raymond; Chetty, Indrin J; Movsas, Benjamin; Ryu, Samuel

    2012-05-10

    The purpose of this study was to perform comprehensive measurements and testing of a Novalis Tx linear accelerator, and to develop technical guidelines for com-missioning from the time of acceptance testing to the first clinical treatment. The Novalis Tx (NTX) linear accelerator is equipped with, among other features, a high-definition MLC (HD120 MLC) with 2.5 mm central leaves, a 6D robotic couch, an optical guidance positioning system, as well as X-ray-based image guidance tools to provide high accuracy radiation delivery for stereotactic radiosurgery and stereotactic body radiation therapy procedures. We have performed extensive tests for each of the components, and analyzed the clinical data collected in our clinic. We present technical guidelines in this report focusing on methods for: (1) efficient and accurate beam data collection for commissioning treatment planning systems, including small field output measurements conducted using a wide range of detectors; (2) commissioning tests for the HD120 MLC; (3) data collection for the baseline characteristics of the on-board imager (OBI) and ExacTrac X-ray (ETX) image guidance systems in conjunction with the 6D robotic couch; and (4) end-to-end testing of the entire clinical process. Established from our clinical experience thus far, recommendations are provided for accurate and efficient use of the OBI and ETX localization systems for intra- and extracranial treatment sites. Four results are presented. (1) Basic beam data measurements: Our measurements confirmed the necessity of using small detectors for small fields. Total scatter factors varied significantly (30% to approximately 62%) for small field measurements among detectors. Unshielded stereotactic field diode (SFD) overestimated dose by ~ 2% for large field sizes. Ion chambers with active diameters of 6 mm suffered from significant volume averaging. The sharpest profile penumbra was observed for the SFD because of its small active diameter (0.6 mm). (2

  11. Fate and distribution of brevetoxin (PbTx) following lysis of Karenia brevis by algicidal bacteria, including analysis of open A-ring derivatives.

    PubMed

    Roth, Patricia B; Twiner, Michael J; Wang, Zhihong; Bottein Dechraoui, Marie-Yasmine; Doucette, Gregory J

    2007-12-15

    Flavobacteriaceae (strain S03) and Cytophaga sp. (strain 41-DBG2) are algicidal bacteria active against the brevetoxin (PbTx)-producing, red tide dinoflagellate, Karenia brevis. Little is known about the fate of PbTx associated with K. brevis cells following attack by such bacteria. The fate and distribution of PbTx in K. brevis cultures exposed to these algicidal strains were thus examined by receptor binding assay and liquid chromatography/mass spectrometry (LC/MS) in three size fractions (>5, 0.22-5, <0.22microm) over a 2-week time course. In control cultures, brevetoxin concentrations in the >5microm particulate size fraction correlated with changes in cell density, whereas significant increases in dissolved (i.e., <0.22microm) toxin were observed in the later stages of culture growth. Exposure of K. brevis to either of the two algicidal bacteria tested caused cell lysis, coinciding with a rapid decline in the >5microm PbTX size fraction and a simultaneous release of dissolved toxin into the growth medium. Upon cell lysis, dissolved brevetoxin accounted for ca. 60% of total toxin and consisted of 51-82% open A-ring derivatives. Open A-ring PbTx-2 and PbTx-3 derivatives bound with lower affinity (approximately 22- and 57-fold, respectively) to voltage-gated sodium channels and were considerably less cytotoxic (86- and 142-fold, respectively) to N2A cells than their individual parent toxins (i.e., PbTx-2 and PbTx-3). These novel findings of changes in PbTx size-fractioned distribution and overall reduction in K. brevis toxicity following attack by algicidal bacteria improve our understanding of potential trophic transfer routes and the fate of PbTx during red tide events. Moreover, this information will be important to consider when evaluating the potential role of algicidal bacteria in harmful algal bloom (HAB) management strategies involving control of bloom populations.

  12. Westchester County Employers Survey.

    ERIC Educational Resources Information Center

    Lee, Marcia M.

    The Westchester County Employers Survey was done in May 2003 in order learn more about employee training needs, how they accomplished these needs, and how it would be possible for the Westchester Community College to fulfill these needs. Out of the 639 surveys sent, 145 were returned in a satisfactory format, which produces a 22.6% return rate.…

  13. [City and County Records.

    ERIC Educational Resources Information Center

    Combs, Judith O.; And Others

    Six papers presented at the Institute were concerned with city and county records. They are: "EWEB and Its Records," which discusses the history, laws and records of the Eugene Water and Electric Board (EWEB);""Police Records: Eugene, Oregon," classifies police records, other than administrative, into three general…

  14. Humboldt County Employer Survey.

    ERIC Educational Resources Information Center

    Lyons, Dave

    A project was undertaken in Humboldt County to collect information from large and small businesses in the areas of agriculture, mining, manufacturing, transportation, wholesale and retail, finance, services, and public information with respect to their employee requirements and needs. In all, 451 firms were surveyed to determine the size of the…

  15. Library Needs of County and County-Wide Groups in Nassau County, New York.

    ERIC Educational Resources Information Center

    Javelin, Muriel C.

    A study, conducted under a grant from Title I of the Library Services and Construction Act, was undertaken to determine: (1) the present level of library service in county and county-wide departments, agencies, and organizations in Nassau County, (2) what additional services are needed, and (3) how these services can best be achieved. Data were…

  16. Solution structure of GxTX-1E, a high affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels†

    PubMed Central

    Lee, Seungkyu; Milescu, Mirela; Jung, Hyun Ho; Lee, Ju Yeon; Bae, Chan Hyung; Lee, Chul Won; Kim, Ha Hyung; Swartz, Kenton J.; Kim, Jae Il

    2010-01-01

    GxTX-1E is a neurotoxin recently isolated from Plesiophrictus guangxiensis venom that inhibits the Kv2.1 channel in pancreatic β-cells. The sequence of the toxin is related to previously studied tarantula toxins that interact with the voltage sensors in Kv channels, and GxTX-1E interacts with the Kv2.1 channel with unusually high affinity, making it particularly useful for structural and mechanistic studies. Here we determined the three-dimensional solution structure of GxTX-1E using NMR spectroscopy and compared it to that of several related tarantula toxins. The molecular structure of GxTX-1E is similar to tarantula toxins that target voltage sensors in Kv channels in that it contains an ICK motif, composed of β-strands, and contains a prominent cluster of solvent-exposed hydrophobic residues surrounded by polar residues. When compared with the structure of SGTx1, a toxin for which mutagenesis data are available, the residue compositions of the two toxins are distinct in regions that are critical for activity, suggesting that their modes of binding to voltage sensors may be different. Interestingly, the structural architecture of GxTX-1E is also similar to JZTX-III, a tarantula toxin that interacts with Kv2.1 with low affinity. The most striking structural differences between GxTX-1E and JZTX-III are found in the orientation between the first and second cysteine loops and the C-terminal region of the toxins, suggesting that these regions of GxTX-1E are responsible for its high affinity. PMID:20509680

  17. Tx/Rx Head Coil Induces Less RF Transmit-Related Heating than Body Coil in Conductive Metallic Objects Outside the Active Area of the Head Coil

    PubMed Central

    Nagy, Zoltan; Oliver-Taylor, Aaron; Kuehne, Andre; Goluch, Sigrun; Weiskopf, Nikolaus

    2017-01-01

    The transmit–receive (Tx/Rx) birdcage head coil is often used for excitation instead of the body coil because of the presumably lower risk of heating in and around conductive implants. However, this common practice has not been systematically tested. To investigate whether the Tx/Rx birdcage head coil produces less heating than the body coil when scanning individuals with implants, we used a 3T clinical scanner and made temperature measurements around a straight 15 cm conductor using either the Tx/Rx body or the head coil for excitation. Additionally, the transmitted fields of a Tx/Rx head coil were measured both in air and in gel using a resonant and a non-resonant B field probes as well as a non-resonant E field probe. Simulations using a finite-difference time domain solver were compared with the experimental findings. When the body coil was used for excitation, we observed heating around the 15 cm wire at various anatomical locations (both within and outside of the active volume of the head coil). Outside its active area, no such heating was observed while using the Tx/Rx head coil for excitation. The E and B fields of the Tx/Rx birdcage head coil extended well-beyond the physical dimensions of the coil. In air, the fields were monotonically decreasing, while in gel they were more complex with local maxima at the end of the ASTM phantom. These experimental findings were line with the simulations. While caution must always be exercised when scanning individuals with metallic implants, these findings support the use of the Tx/Rx birdcage head coil in place of the body coil at 3T in order to reduce the risk of heating in and around conductive implants that are remote from the head coil. PMID:28184184

  18. Tx/Rx Head Coil Induces Less RF Transmit-Related Heating than Body Coil in Conductive Metallic Objects Outside the Active Area of the Head Coil.

    PubMed

    Nagy, Zoltan; Oliver-Taylor, Aaron; Kuehne, Andre; Goluch, Sigrun; Weiskopf, Nikolaus

    2017-01-01

    The transmit-receive (Tx/Rx) birdcage head coil is often used for excitation instead of the body coil because of the presumably lower risk of heating in and around conductive implants. However, this common practice has not been systematically tested. To investigate whether the Tx/Rx birdcage head coil produces less heating than the body coil when scanning individuals with implants, we used a 3T clinical scanner and made temperature measurements around a straight 15 cm conductor using either the Tx/Rx body or the head coil for excitation. Additionally, the transmitted fields of a Tx/Rx head coil were measured both in air and in gel using a resonant and a non-resonant B field probes as well as a non-resonant E field probe. Simulations using a finite-difference time domain solver were compared with the experimental findings. When the body coil was used for excitation, we observed heating around the 15 cm wire at various anatomical locations (both within and outside of the active volume of the head coil). Outside its active area, no such heating was observed while using the Tx/Rx head coil for excitation. The E and B fields of the Tx/Rx birdcage head coil extended well-beyond the physical dimensions of the coil. In air, the fields were monotonically decreasing, while in gel they were more complex with local maxima at the end of the ASTM phantom. These experimental findings were line with the simulations. While caution must always be exercised when scanning individuals with metallic implants, these findings support the use of the Tx/Rx birdcage head coil in place of the body coil at 3T in order to reduce the risk of heating in and around conductive implants that are remote from the head coil.

  19. Biochemical and functional studies of ColTx-I, a new myotoxic phospholipase A2 isolated from Crotalus oreganus lutosus (Great Basin rattlesnake) snake venom.

    PubMed

    Almeida, J R; Resende, L M; Silva, A G; Ribeiro, R I M A; Stábeli, R G; Soares, A M; Calderon, L A; Marangoni, S; Da Silva, S L

    2016-07-01

    Commonly, phospholipases A2 (PLA2s) play key roles in the pathogenesis of the local tissue damage characteristic of crotaline and viperine snake envenomations. Crotalus oreganus lutosus snake venom has not been extensively studied; therefore, the characterization of its components represents a valuable biotechnological tool for studying pathophysiological processes of envenoming and for gaining a deeper understanding of its biological effects. In this study, for the first time, a basic PLA2 myotoxin, ColTx-I, was purified from C. o. lutosus through two chromatographic steps. ColTx-I is monomeric with calculated molecular mass weight (Mw) of 14,145 Da and a primary structure closely related to basic PLA2s from viperid venoms. The pure enzyme has a specific activity of 15.87 ± 0.65 nmol/min/mg at optimal conditions (pH 8.0 and 37 °C). ColTx-I activity was found to be dependent on Ca(2+), as its substitution by other ionic species as well as the addition of chelating agents significantly reduced its phospholipase activity. In vivo, ColTx-I triggered dose-dependent inflammatory responses, measured using the paw edema model, with an increase in IL-6 levels, systemic and local myotoxicity, characterized by elevated plasma creatine kinase activity. ColTx-I induced a complex series of degenerative events associated with edema, inflammatory infiltrate and skeletal muscle necrosis. These biochemical and functional results suggest that ColTx-I, a myotoxic and inflammatory mediator, plays a relevant role in C. o. lutosus envenomation. Thus, detailed studies on its mechanism of action, such as evaluating the synergism between ColTx-I and other venom components may reveal targets for the development of more specific and effective therapies.

  20. Inflammatory oedema induced by Lachesis muta muta (Surucucu) venom and LmTX-I in the rat paw and dorsal skin.

    PubMed

    Ferreira, Tatiane; Camargo, Enilton A; Ribela, Maria Teresa C P; Damico, Daniela C; Marangoni, Sérgio; Antunes, Edson; De Nucci, Gilberto; Landucci, Elen C T

    2009-01-01

    The ability of crude venom and a basic phospholipase A(2) (LmTX-I) from Lachesis muta muta venom to increase the microvascular permeability in rat paw and skin was investigated. Crude venom or LmTX-I were injected subplantarly or intradermally and rat paw oedema and dorsal skin plasma extravasation were measured. Histamine release from rat peritoneal mast cell was also assessed. Crude venom or LmTX-I induced dose-dependent rat paw oedema and dorsal skin plasma extravasation. Venom-induced plasma extravasation was inhibited by the histamine H(1) antagonist mepyramine (6mg/kg), histamine/5-hydroxytriptamine antagonist cyproheptadine (2mg/kg), cyclooxygenase inhibitor indomethacin (5mg/kg), nitric oxide synthesis inhibitor l-NAME (100nmol/site), tachykinin NK(1) antagonist SR140333 (1nmol/site) and bradykinin B(2) receptor antagonist Icatibant (0.6mg/kg). Platelet-activating factor (PAF) antagonist PCA4248 (5mg/kg) had no effect. LmTX-I-induced skin extravasation was inhibited by cyproheptadine, mepyramine, indomethacin and PCA4248, while l-NAME and SR140333 had no effect. Additionally, both Lachesis muta muta venom and LmTX-I concentration-dependently induced histamine release from rat mast cells. In conclusion, Lachesis muta muta venom and LmTX-I increase microvascular permeability by mechanisms involving in vivo mast cell activation and arachidonic acid metabolites. Additionally, crude venom-induced responses also involve substance P, nitric oxide and bradykinin release, whether LmTX-I-induced responses involve PAF.

  1. Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1.

    PubMed Central

    Savarin, P.; Romi-Lebrun, R.; Zinn-Justin, S.; Lebrun, B.; Nakajima, T.; Gilquin, B.; Menez, A.

    1999-01-01

    We have determined the three-dimensional structure of the potassium channel inhibitor HsTX1, using nuclear magnetic resonance and molecular modeling. This protein belongs to the scorpion short toxin family, which essentially contains potassium channel blockers of 29 to 39 amino acids and three disulfide bridges. It is highly active on voltage-gated Kv1.3 potassium channels. Furthermore, it has the particularity to possess a fourth disulfide bridge. We show that HsTX1 has a fold similar to that of the three-disulfide-bridged toxins and conserves the hydrophobic core found in the scorpion short toxins. Thus, the fourth bridge has no influence on the global conformation of HsTX1. Most residues spatially analogous to those interacting with voltage-gated potassium channels in the three-disulfide-bridged toxins are conserved in HsTX1. Thus, we propose that Tyr21, Lys23, Met25, and Asn26 are involved in the biological activity of HsTX1. As an additional positively charged residue is always spatially close to the aromatic residue in toxins blocking the voltage-gated potassium channels, and as previous mutagenesis experiments have shown the critical role played by the C-terminus in HsTX1, we suggest that Arg33 is also important for the activity of the four disulfide-bridged toxin. Docking calculations confirm that, if Lys23 and Met25 interact with the GYGDMH motif of Kv1.3, Arg33 can contact Asp386 and, thus, play the role of the additional positively charged residue of the toxin functional site. This original configuration of the binding site of HsTX1 for Kv1.3, if confirmed experimentally, offers new structural possibilities for the construction of a molecule blocking the voltage-gated potassium channels. PMID:10631983

  2. Biochemical Characterization and Pharmacological Properties of New Basic PLA2 BrTX-I Isolated from Bothrops roedingeri (Roedinger's Lancehead) Mertens, 1942, Snake Venom

    PubMed Central

    Gomes Heleno, Mauricio Aurelio; Baldasso, Paulo Aparecido; Ponce-Soto, Luis Alberto; Marangoni, Sérgio

    2013-01-01

    BrTX-I, a PLA2, was purified from Bothrops roedingeri venom after only one chromatographic step using reverse-phase HPLC on μ-Bondapak C-18 column. A molecular mass of 14358.69 Da was determined by MALDI-TOF mass spectrometry. Amino acid analysis showed a high content of hydrophobic and basic amino acids as well as 14 half-cysteine residues. The total amino acid sequence was obtained using SwissProt database and showed high amino acid sequence identity with other PLA2 from snake venom. The amino acid composition showed that BrTX-I has a high content of Lys, Tyr, Gly, Pro, and 14 half-Cys residues, typical of a basic PLA2. BrTX-I presented PLA2 activity and showed a minimum sigmoidal behavior, reaching its maximal activity at pH 8.0, 35–45°C, and required Ca2+. In vitro, the whole venom and BrTX-I caused a neuromuscular blockade in biventer cervicis preparations in a similar way to other Bothrops species. BrTX-I induced myonecrosis and oedema-forming activity analyzed through injection of the purified BrTX-I in mice. Since BrTX-I exerts a strong proinflammatory effect, the enzymatic phospholipid hydrolysis might be relevant for these phenomena; incrementing levels of IL-1, IL-6, and TNFα were observed at 15 min, 30 min, one, two, and six hours postinjection, respectively. PMID:23509747

  3. Isolation and characterization of SsmTx-I, a Specific Kv2.1 blocker from the venom of the centipede Scolopendra Subspinipes Mutilans L. Koch.

    PubMed

    Chen, Minzhi; Li, Jing; Zhang, Fan; Liu, Zhonghua

    2014-03-01

    Scolopendra subspinipes mutilans, also known as Chinese red-headed centipede, is a venomous centipede from East Asia and Australasia. Venom from this animal has not been researched as thoroughly as venom from snakes, snails, scorpions, and spiders. In this study, we isolated and characterized SsmTx-I, a novel neurotoxin from the venom of S. subspinipes mutilans. SsmTx-I contains 36 residues with four cysteines forming two disulfide bonds. It had low sequence similarity (<10%) with other identified peptide toxins. By whole-cell recording, SsmTx-I significantly blocked voltage-gated K⁺ channels in dorsal root ganglion neurons with an IC₅₀ value of 200 nM, but it had no effect on voltage-gated Na⁺ channels. Among the nine K⁺ channel subtypes expressed in human embryonic kidney 293 cells, SsmTx-I selectively blocked the Kv2.1 current with an IC₅₀ value of 41.7 nM, but it had little effect on currents mediated by other K⁺ channel subtypes. Blockage of Kv2.1 by SsmTx-I was not associated with significant alteration of steady-state activation, suggesting that SsmTx-I might act as a simple inhibitor or channel blocker rather than a gating modifier. Our study reported a specific Kv2.1-blocker from centipede venom and provided a basis for future investigations of SsmTx-I, for example on structure-function relationships, mechanism of action, and pharmacological potential.

  4. Geophysical Investigation of an Abandoned Cemetery: Teachers Discover Evidence of Unmarked Graves in Prairie View, TX

    NASA Astrophysics Data System (ADS)

    Henning, A. T.; Sawyer, D. S.; Baldwin, R.; Kahera, A.; Thoms, A.

    2007-12-01

    In July 2007, a group of nineteen K-12 teachers investigated an abandoned cemetery in Prairie View, Texas, utilizing ground-penetrating radar (GPR) to image the subsurface. In a period of two weeks, the group acquired and interpreted 59 GPR profiles in Wyatt Chapel Cemetery and surrounding areas in order to determine the local stratigraphy and try to locate unmarked graves. The sandy soil in this area is ideally suited for GPR investigations and numerous geophysical anomalies were identified. Wyatt Chapel Cemetery is located adjacent to the campus of Prairie View A&M University in Prairie View, TX, and is thought to have originated as a slave burial ground in the 1850's. Participants in a summer course at Rice University conducted a geophysical investigation of the site. Participants were in-service K-12 teachers from urban Houston school districts where the majority of students are members of historically underrepresented minority groups. Recruitment efforts targeted educators who are currently teaching science without a science degree. Participants included elementary, middle and high school teachers. This summer experience is followed by a content-intensive academic year course in Physical Geology. GPR is an excellent tool for investigating the sandy soil encountered at Wyatt Chapel Cemetery. The stratigraphy in the area consists of 3-6 feet of reddish-brown, medium-grained sand overlying a light gray, highly compacted clay. The sand-clay boundary appears as a strong reflector on the GPR profiles. Participants identified numerous anomalies in the GPR data and two were excavated. One consisted of a pair of bright hyperbolae, suggesting two edges of a metal object. This excavation resulted in the discovery of a metal plank thought to be a burial cover. The second anomaly consisted of a break in the horizon representing the top of the clay layer, and subsequent excavation revealed a grave shaft. Participants experienced the process of science first-hand and used

  5. A Large-N Mixed Sensor Active + Passive Seismic Array near Sweetwater, TX

    NASA Astrophysics Data System (ADS)

    Barklage, M.; Hollis, D.; Gridley, J. M.; Woodward, R.; Spriggs, N.

    2014-12-01

    A collaborative high-density seismic survey using broadband and short period seismic sensors was conducted March 7 - April 30, 2014 near Sweetwater, TX. The objective of the survey was to use a combination of controlled source shot slices and passive seismic recordings recorded by multiple types of sensors with different bandwidths and sensitivities to image the subsurface. The broadband component of the survey consisted of 25 continuously recording seismic stations comprised of 20 Trillium Compact Posthole sensors from Nanometrics and 5 Polar Trillium 120PHQs from the IRIS/PASSCAL Instrument Center (PIC). The broadband stations also utilized 25 Centaur digitizers from Nanometrics as well as 25 polar quick deploy enclosures from the PIC. The broadband array was designed to maximize horizontal traveling seismic energy for surface wave analysis over the primary target area with sufficient offset for imaging objectives at depth. The short period component of the survey consisted of 2639 receiver locations using Zland nodes from NodalSeismic. The nodes are further divided into 3 sub-arrays: 1) outlier array 2) active source array 3) backbone array. The outlier array consisted of 25 continuously recording nodes distributed around the edge of the survey at a distance of ~5 km from the survey boundary, and provided valuable constraints to passive data analysis techniques at the edge of the survey boundary. The active source patch consisted of densely spaced nodes that were designed to record signals from a Vibroseis source truck for active source reflection processing and imaging. The backbone array consisted of 292 nodes that covered the entirety of the survey area to maximize the value of the passive data analysis. By utilizing continuous recording and smartly designed arrays for measuring local and regional earthquakes we can incorporate velocity information derived from passive data analysis into the active source processing workflow to produce a superior subsurface

  6. 77 FR 73005 - Revisions to the California State Implementation Plan, Imperial County, Placer County, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... County, and Ventura County Air Pollution Control Districts AGENCY: Environmental Protection Agency (EPA... Pollution Control District (ICAPCD), Placer County Air Pollution Control District (PCAPCD) and Ventura County Air Pollution Control District (PCAPCD) portions of the California State Implementation Plan...

  7. Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: our 1 year experience.

    PubMed

    Chang, Zheng; Bowsher, James; Cai, Jing; Yoo, Sua; Wang, Zhiheng; Adamson, Justus; Ren, Lei; Yin, Fang-Fang

    2012-07-05

    American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation therapy (IGRT). The recommendations of AAPM TG 142 on IGRT are timely. In our institute, we established a comprehensive imaging QA program on a medical accelerator based on AAPM TG 142 and implemented it successfully. In this paper, we share our one-year experience and performance evaluation of an OBI capable linear accelerator, Novalis Tx, per TG 142 guidelines.

  8. Occurrence of metallothionein gene smtA in synechococcus Tx-20 and other blue-green algae

    SciTech Connect

    Robinson, N.J.; Gupta, A.; Huckle, J.W.; Jackson, P.; Whitton, B.A. )

    1990-06-01

    Blue-green algae are often abundant at Zn- and Cd-contaminated sites. In order to understand the mechanisms associated with Zn- and Cd-tolerance, we have isolated a metallothionein gene, designated smtA, in Synechococcus Tx-20 (- Pcc 6301 - Anacystis nidulans), a strain apparently obtained from an unpolluted site. The gene was cloned and sequenced, and its expression investigated in a range of heavy-metal-tolerant strains of the same organism obtained by stepwise adaptation. The polymerase chain reaction was used to probe for the possible presence of the homologous gene in a range of other strains (especially Synechococcus) isolated from sites without and with heavy metal contamination.

  9. Mono County update

    SciTech Connect

    Lyster, D. )

    1988-12-01

    The Mono County Board of Supervisors approved the issuance of a use-permit for the Mammoth-Pacific II geothermal power plant. The power plant will be a binary, air-cooled, 10-megawatt, net, project. An appeal was filed by the California Department of Fish and Game, and the permit will not take effect until this appeal is resolved. Mono County also issued a project use-permit to proposers of Bonneville Pacific Corporations Mammoth Chance Geothermal Project, also a 10-megawatt, net, binary and air-cooled project. The permit was appealed by the Sierra Club, Cal-Trout, and the California Department of Fish and Game. Now, a subsequent EIR must be prepared for public review and comment. The subsequent EIR will address the issue of cumulative impacts and will include a discussion of new information.

  10. Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

    PubMed

    Murray, Justin K; Biswas, Kaustav; Holder, J Ryan; Zou, Anruo; Ligutti, Joseph; Liu, Dong; Poppe, Leszek; Andrews, Kristin L; Lin, Fen-Fen; Meng, Shi-Yuan; Moyer, Bryan D; McDonough, Stefan I; Miranda, Les P

    2015-11-01

    Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel NaV1.7 as new analgesics. Thus far, however, in vitro selectivity has proved difficult for small molecules, and peptides generally lack appropriate pharmacokinetic properties. We previously identified the NaV1.7 inhibitory peptide GpTx-1 from tarantula venom and optimized its potency and selectivity via structure-guided analoging. To further understand GpTx-1 binding to NaV1.7, we have mapped the binding site to transmembrane segments 1-4 of the second pseudosubunit internal repeat (commonly referred to as Site 4) using NaV1.5/NaV1.7 chimeric protein constructs. We also report that select GpTx-1 amino acid residues apparently not contacting NaV1.7 can be derivatized with a hydrophilic polymer without adversely affecting peptide potency. Homodimerization of GpTx-1 with a bifunctional polyethylene glycol (PEG) linker resulted in a compound with increased potency and a significantly reduced off-rate, demonstrating the ability to modulate the function and properties of GpTx-1 by linking to additional molecules.

  11. Characterization of a Novel Alpha-Conotoxin TxID from Conus textile that Potently Blocks rat Alpha3beta4 Nicotinic Acetylcholine Receptors

    PubMed Central

    Luo, Sulan; Zhangsun, Dongting; Zhu, Xiaopeng; Wu, Yong; Hu, Yuanyan; Christensen, Sean; Harvey, Peta J.; Akcan, Muharrem; Craik, David J.; McIntosh, J. Michael

    2014-01-01

    The α3β4 nAChRs are implicated in pain sensation in the PNS and addiction to nicotine in the CNS. We identified an α-4/6-conotoxin (CTx) TxID from Conus textile. The new toxin consists of 15 amino acid residues with two disulfide bonds. TxID was synthesized using solid phase methods and the synthetic peptide was functionally tested on nAChRs heterologously expressed in Xenopus laevis oocytes. TxID blocked rat α3β4 nAChRs with a 12.5 nM IC50, which places it amongst the most potent α3β4 nAChR antagonists. TxID also blocked the closely related α6/α3β4 with a 94 nM IC50 but showed little activity on other nAChR subtypes. NMR analysis showed that two major structural isomers exist in solution, one of which adopts a regular α-CTx fold but with different surface charge distribution to other 4/6 family members. α-CTx TxID is a novel tool with which to probe the structure and function of α3β4 nAChRs. PMID:24200193

  12. Mono County update

    SciTech Connect

    Lyster, D.L.

    1987-07-01

    In May 1987, the Mono County Energy Management Department recommended that a two-year moratorium be placed on geothermal power production projects on private lands within the Mono-Long Valley KGRA. The intent of the proposed moratorium was to allow for the collection and evaluation of hydrologic monitoring data in the Long Valley Caldera. Now, to still achieve this end, the Energy Management Department will suggest that mitigation measures and project-specific monitoring requirements be implemented via the California Environmental Quality Act (CEQA) documentation and the county use permit process. The monitoring data will provide important information to Mono County decision-makers regarding potential adverse impacts from geothermal production on such local resources as Hot Creek Gorge, the Hot Creek Fish Hatchery, and Hot Creek, itself. The Mammoth/Chance Geothermal Project is the proposed construction and operation of a 10 megawatt, net, geothermal binary-cycle power plant and production- and injection-well field by Bonneville Pacific Corporation. The project is currently under environmental review, pursuant to CEQA requirements. The Mono County Energy Management Director is providing assistance to the Town of Mammoth Lakes on its California Energy Commission (CEC) grant-funded resource assessment project. The grant of $220,000 provides for the drilling of at least two temperature-gradient wells (exploratory wells) within the town limits. If a geothermal resource is detected and found to provide adequate flows at a suitable temperature, the Town of Mammoth Lakes will proceed in the development of a geothermal space-heating system to provide heat to such users as the Centinela Mammoth Hospital, Mammoth elementary and high schools, the Gateway Industrial Park, and future residential development projects.

  13. Mono County update

    SciTech Connect

    Lyster, D.L.

    1987-06-01

    On February 9, 1988, the Mono County Board of Supervisors voted to approve Bonneville Pacific Corporation's Mammoth Chance Geothermal Project. The project is an air-cooled, binary, geothermal power plant, 10 megawatts, net. The Mono County Board of Supervisors issued a project use-permit with vigorous and stringent conditions. Specific emphasis was placed on the establishment of a monitoring program designed to detect the effects of geothermal development on the springs at the Hot Creek Fish Hatchery and Hot Creek Gorge. On October 5, 1987, the Mono County Planning Commission granted a use-permit to Mammoth Pacific for its Mammoth Pacific II Project, a binary, air-cooled, geothermal power plant, 10 megawatts, net. The issuance of the use-permit instigated an appeal by the Sierra Club. That appeal was heard on February 22, 1988, At the end of the testimony, the Board of Supervisors voted to uphold the appeal of the Sierra Club, thereby denying the project by a vote of 3 to 2. The main areas of concern voiced by the majority of the Board included potential hydrologic impacts to Hot Creek Gorge and Hot Creek Fish Hatchery, visual impacts, and impacts to mule deer migration and survival. One of the options now available to Mammoth Pacific is to request that the project be denied without prejudice. This would allow Mammoth Pacific to return to the Board immediately with additional material regarding its concerns.

  14. Somerset County Renewable Energy Initiative

    SciTech Connect

    Katula, Denise

    2014-05-07

    The County of Somerset, New Jersey, through the Somerset County Improvement Authority (SCIA), applied Federal funding through the U.S. Department of Energy to will apply project funds to buy-down the capital costs of equipment associated with the installation of solar photovoltaic (PV) systems at two sites owned by the County. This Renewable Energy Initiative allows the County to take advantage of clean renewable energy, without any adverse debt impacts, and at a price that results in operating budget savings beyond what is presently available in the marketplace. This project addressed the objectives of the Office of Energy Efficiency and Renewable Energy by making the acquisition of renewable energy more affordable for the County, thereby, encouraging other counties and local units to develop similar programs and increase the deployment of solar energy technologies. The two sites that were funded by the DOE grant are part of a much larger, ambitious, and unique renewable energy project, described in the next section.

  15. Modeling erosion and sediment control practices in RUSLE 2.0: A management approach for natural gas well sites in Denton County, TX, USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sediment yields from natural gas well sites can be substantial and warrant consideration of appropriate erosion and sediment control Best Management Practices(BMPs). Version 2 of the Revised Universal Soil Loss Equation (RUSLE 2.0) was used to predict sediment yields and evaluate the efficiency of ...

  16. Growth of Pseudomonas sp. TX1 on a wide range of octylphenol polyethoxylate concentrations and the formation of dicarboxylated metabolites.

    PubMed

    Lin, Yi-Wen; Guo, Gia-Luen; Hsieh, Hsiao-Cheng; Huang, Shir-Ly

    2010-04-01

    Pseudomonas sp. TX1, is able to use octylphenol polyethoxylates (OPEO(n), or Triton X-100; average n = 9.5) as a sole carbon source. It can grow on 0.05-20% of OPEO(n) with a specific growth rate of 0.34-0.44 h(-1). High-performance liquid chromatography-mass spectrometer analysis of OPEO(n) degraded metabolites revealed that strain TX1 was able to shorten the ethoxylate chain and produce octylphenol (OP). Furthermore, formation of the short carboxylate metabolites, such as carboxyoctylphenol polyethoxylates (COPEO(n), n = 2, 3) and carboxyoctylphenol polyethoxycarboxylates (COPEC(n), n = 2, 3) began at the log stage, while octylphenol polyethoxycarboxylates (OPEC(n), n = 1-3) was formed at the stationary phase. All the short-ethoxylated metabolites, OPEO(n), OPEC(n), COPEO(n), and COPEC(n), accumulated when the cells were in the stationary phase. This study is the first to demonstrate the formation of COPEO(n) and COPEC(n) from OPEO(n) by an aerobic bacterium.

  17. Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch.

    PubMed

    Zhu, Jing; Tong, Xiaotian; Cao, Chunyang; Wu, Gong; Zhang, Naixia; Wu, Houming

    2010-01-01

    The solution structure of BmKalphaTx11 presented by this paper is distinctive from any other structures of wide-type scorpion alpha-toxins reported so far, for its trans-9,10 peptide bond conformation is accompanied by 'protruding' topology of the 'NC-domain'. The orientation of the C-tail of BmKalphaTx11 is obviously different from that of classical alpha-toxins (e.g., AaH2, BmK-M8), despite the fact that they share common trans conformation of peptide bond between residues 9 and 10. Accordingly, there must be other structural factors dominating the orientation of the C-tail except the conformation of peptide bond 9-10. Our study reveals that residues at position 58 play an important role in it, and different type of residues at this position (e.g., Lys, Arg, Met, Ile) result in different spatial relationship between the C-terminus and the 'five-residue-turn' and then different topology of the 'NC-domain', therefore residues at position 58 are believed to function as structure and bioactivity switch for specificity of scorpion alpha-toxins. The mechanism for stabilizing the geometry of the 'NC-domain' in wide-type scorpion alpha-toxins is also discussed.

  18. Wind Energy Guide for County Commissioners

    EPA Pesticide Factsheets

    This report provides county commissioners, planners, and other local county government officials with a practical overview of information required to successfully implement commercial wind energy projects in their county.

  19. CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles.

    PubMed

    Almeida, J R; Lancellotti, M; Soares, A M; Calderon, L A; Ramírez, D; González, W; Marangoni, S; Da Silva, S L

    2016-09-15

    Snake venoms are rich and intriguing sources of biologically-active molecules that act on target cells, modulating a diversity of physiological functions and presenting promising pharmacological applications. Lys49 phospholipase A2 is one of the multifunctional proteins present in these complex secretions and, although catalytically inactive, has a variety of biological activities, including cytotoxic, antibacterial, inflammatory, antifungal activities. Herein, a Lys49 phospholipase A2, denominated CoaTx-II from Crotalus oreganus abyssus, was purified and structurally and pharmacologically characterized. CoaTx-II was isolated with a high degree of purity by a combination of two chromatographic steps; molecular exclusion and reversed-phase high performance liquid chromatography. This toxin is dimeric with a mass of 13868.2 Da (monomeric form), as determined by mass spectrometry. CoaTx-II is rich in Arg and Lys residues and displays high identity with other Lys49 PLA2 homologues, which have high isoelectric points. The structural model of dimeric CoaTx-II shows that the toxin is non-covalently stabilized. Despite its enzymatic inactivity, in vivo CoaTx-II caused local muscular damage, characterized by increased plasma creatine kinase and confirmed by histological alterations, in addition to an inflammatory activity, as demonstrated by mice paw edema induction and pro-inflammatory cytokine IL-6 elevation. CoaTx-II also presents antibacterial activity against gram negative (Pseudomonas aeruginosa 31NM, Escherichia coli ATCC 25922) and positive (Staphyloccocus aureus BEC9393 and Rib1) bacteria. Therefore, data show that this newly purified toxin plays a central role in mediating the degenerative events associated with envenomation, in addition to demonstrating antibacterial properties, with potential for use in the development of strategies for antivenom therapy and combating antibiotic-resistant bacteria.

  20. SURFACE GEOPHYSICAL EXPLORATION OF TX-TY TANK FARMS AT THE HANFORD SITE RESULTS OF BACKGROUND CHARACTERIZATION WITH GROUND PENETRATING RADAR

    SciTech Connect

    MYERS DA; CUBBAGE R; BRAUCHLA R; O'BRIEN G

    2008-07-24

    Ground penetrating radar surveys of the TX and TY tank farms were performed to identify existing infrastructure in the near surface environment. These surveys were designed to provide background information supporting Surface-to-Surface and Well-to-Well resistivity surveys of Waste Management Area TX-TY. The objective of the preliminary investigation was to collect background characterization information with GPR to understand the spatial distribution of metallic objects that could potentially interfere with the results from high resolution resistivity{trademark} surveys. The results of the background characterization confirm the existence of documented infrastructure, as well as highlight locations of possible additional undocumented subsurface metallic objects.

  1. Mono County geothermal activity

    SciTech Connect

    Lyster, D.L.

    1986-01-01

    Three geothermal projects have been proposed or are underway in Mono County, California. The Mammoth/Chance geothermal development project plans to construct a 10-MW geothermal binary power plant which will include 8 production and 3 injection wells. Pacific Lighting Energy Systems is also planning a 10-MW binary power plant consisting of 5 geothermal wells and up to 4 injection wells. A geothermal research project near Mammoth Lakes has spudded a well to provide a way to periodically measure temperature gradient, pressure, and chemistry of the thermal waters and to investigate the space-heating potential of the area in the vicinity of Mammoth Lakes. All three projects are briefly described.

  2. Menominee: Wisconsin's 72nd County.

    ERIC Educational Resources Information Center

    Weidemann, Wayne H.; Fuguitt, Glenn V.

    Menominee Indian Reservation became a county after the 1960 Census of Population; therefore, data for the county as a unit were distributed throughout the census publication and appeared as civil division tabulation. This 1963 report attempts to compile these data, as well as data from previous census publications, and present them in easily…

  3. A Conversation on Distressed Counties.

    ERIC Educational Resources Information Center

    Russell, Jack; Baldwin, Fred D.

    1998-01-01

    In 1999, 108 of Appalachia's 406 counties were "distressed," with high poverty and unemployment rates. Three experts on Appalachia (Ron Eller, Amy K. Glasmeier, Greg Bischak) discuss problems and potentials of these counties, focusing on the working poor, welfare reform, the utility of social indicators, the challenge of changing the…

  4. Frederick County Community Perception Survey.

    ERIC Educational Resources Information Center

    Frederick Community Coll., MD.

    In 1997, Frederick Community College (FCC) in Maryland conducted a telephone survey of a random sample of 466 Frederick County residents to identify their perceptions of the college. In particular, the survey examined Frederick County residents' image of FCC, level of awareness of services and programs offered by FCC, and the types of services…

  5. Walking to Save a County.

    ERIC Educational Resources Information Center

    Slotnick, Karen

    1981-01-01

    Describes the 10-year history and accomplishments of the Walk to Save the County which has preserved more than 400 acres of Onondaga County, New York. Outlines organizational structure, promotional strategies, awards, and educational opportunities involved in this annual fund-raising hike by third- through eighth-grade students. (NEC)

  6. 77 FR 1015 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... Rgnl, RNAV (GPS) RWY 35, Amdt 2 Houston, TX, Sugar Land Rgnl, VOR/DME-A, Amdt 2 Marshall, TX, Harrison County, GPS RWY 33, Orig-F, CANCELLED Marshall, TX, Harrison County, RNAV (GPS) RWY 15, Orig Marshall, TX, Harrison County, RNAV (GPS) RWY 33, Orig Marshall, TX, Harrison County, Takeoff Minimums and Obstacle...

  7. Hydrology of Polk County, Florida

    USGS Publications Warehouse

    Spechler, Rick M.; Kroening, Sharon E.

    2007-01-01

    Local water managers usually rely on information produced at the State and regional scale to make water-resource management decisions. Current assessments of hydrologic and water-quality conditions in Polk County, Florida, commonly end at the boundaries of two water management districts (South Florida Water Management District and the Southwest Florida Water Management District), which makes it difficult for managers to determine conditions throughout the county. The last comprehensive water-resources assessment of Polk County was published almost 40 years ago. To address the need for current countywide information, the U.S. Geological Survey began a 3?-year study in 2002 to update information about hydrologic and water-quality conditions in Polk County and identify changes that have occurred. Ground-water use in Polk County has decreased substantially since 1965. In 1965, total ground-water withdrawals in the county were about 350 million gallons per day. In 2002, withdrawals totaled about 285 million gallons per day, of which nearly 95 percent was from the Floridan aquifer system. Water-conservation practices mainly related to the phosphate-mining industry as well as the decrease in the number of mines in operation in Polk County have reduced total water use by about 65 million gallons per day since 1965. Polk County is underlain by three principal hydrogeologic units. The uppermost water-bearing unit is the surficial aquifer system, which is unconfined and composed primarily of clastic deposits. The surficial aquifer system is underlain by the intermediate confining unit, which grades into the intermediate aquifer system and consists of up to two water-bearing zones composed of interbedded clastic and carbonate rocks. The lowermost hydrogeologic unit is the Floridan aquifer system. The Floridan aquifer system, a thick sequence of permeable limestone and dolostone, consists of the Upper Floridan aquifer, a middle semiconfining unit, a middle confining unit, and

  8. 2004 Initial Assessments for the T and TX TY Tank Farm Field Investigation Report (FIR): Numerical Simulations

    SciTech Connect

    Zhang, Z. F.; Freedman, Vicky L.; Waichler, Scott R.

    2004-09-24

    In support of CH2M HILL Hanford Group, Inc.’s (CHG) preparation of a Field Investigative Report (FIR) for the Hanford Site Single-Shell Tank Waste Management Area (WMA) T and TX-TY, a suite of numerical simulations of flow and solute transport was executed using the STOMP code to predict the performance of surface barriers for reducing long-term risks from potential groundwater contamination at the T and TX-TY WMA. The scope and parametric data for these simulations were defined by a modeling data package provided by CHG. This report documents the simulation involving 2-D cross sections through the T Tank and the TX-TY Tank Farm. Eight cases were carried out for the cross sections to simulate the effects of interim barrier, water line leak, inventory distribution, and surface recharge on water flow and the transport of long-lived radionuclides (i.e., technecium-99 and uranium) and chemicals (i.e., nitrate and chromium For simulations with barriers, it is assumed that an interim barrier is in place by the year 2010. It was also assumed that, for all simulations, as part of tank farm closure, a closure barrier was in place by the year 2040. The modeling considers the estimated inventories of contaminants within the vadose zone and calculates the associated risk. It assumes that no tanks will leak in the future. Initial conditions for contaminant concentration are provided as part of inventory estimates for uranium, technetium-99, nitrate, and chromium. For moisture flow modeling, Neumann boundary conditions are prescribed at the surface with the flux equal to the recharge rate estimate. For transport modeling, a zero flux boundary is prescribed at the surface for uranium, technetium-99, nitrate, and chromium. The western and eastern boundaries are assigned no-flux boundaries for both flow and transport. The water table boundary is prescribed by water table elevations and the unconfined aquifer hydraulic gradient. No-flux boundaries are used for the lower boundary

  9. Alternating magnetic anisotropy of Li2(Li1–xTx)N (T = Mn, Fe, Co, and Ni)

    DOE PAGES

    Jesche, A.; Ke, L.; Jacobs, J. L.; ...

    2015-05-11

    Substantial amounts of the transition metals Mn, Fe, Co, and Ni can be substituted for Li in single crystalline Li2(Li1–xTx)N. Isothermal and temperature-dependent magnetization measurements reveal local magnetic moments with magnitudes significantly exceeding the spin-only value. The additional contributions stem from unquenched orbital moments that lead to rare-earth-like behavior of the magnetic properties. Accordingly, extremely large magnetic anisotropies have been found. Most notably, the magnetic anisotropy alternates as easy plane→easy axis→easy plane→easy axis when progressing from T = Mn → Fe → Co → Ni. This behavior can be understood based on a perturbation approach in an analytical, single-ion model.more » As a result, the calculated magnetic anisotropies show surprisingly good agreement with the experiment and capture the basic features observed for the different transition metals.« less

  10. Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Alvin, TX, Six-Month Evaluation Report

    EPA Science Inventory

    This report documents the activities performed and the results obtained from the first six months of the EPA arsenic removal technology demonstration project at the Oak Manor Municipal Utility District (MUD) facility at Alvin, TX. The main objective of the project is to evaluate...

  11. Registration of seed sterile, Perennial Sorghum spp. [Sorghum bicolor (L.) Moench x S. halepense (L.) Pers.] Hybrid 'PSH09TX15'

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A novel, Perennial Sorghum spp. Hybrid (PSH) [Sorghum bicolor (L.) Moench x S. halepense (L.) Pers.] ('PSH09TX15'; PI ______) was identified that possessed complete seed sterility, only rare occurrences (< 0.1%) of flowering, and significantly higher mean leaf number per tiller than S. halepense. I...

  12. Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Wellman, TX, Final Performance Evaluation Report

    EPA Science Inventory

    This report documents the activities performed and the results obtained from the arsenic removal treatment technology demonstration project in the City of Wellman, TX. The main objective of the project was to evaluate the effectiveness of AdEdge Technologies’ AD-33 media in remo...

  13. Arsenic Removal from Drinking Water by Adsorptive Media. U.S. EPA Demonstration Project at Oak Manor Municipal Utility District at Alvin, TX. Final Performance Evaluation Report

    EPA Science Inventory

    This report documents the activities performed and the results obtained for the EPA arsenic removal technology demonstration project at the Oak Manor Municipal Utility District (MUD) facility in Alvin, TX. The objectives of the project were to evaluate 1) the effectiveness of a ...

  14. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice.

    PubMed

    Tanaka, Ken-Ichiro; Sekino, Shota; Ikegami, Megumi; Ikeda, Hiroko; Kamei, Junzo

    2015-01-01

    The present study investigated the effects of intrathecal administration of ProTx-II (tarantula venom peptide) and A803467 (5-[4-chloro-phenyl]-furan-2-carboxylic acid [3,5-dimethoxy-phenyl]-amide), selective Nav1.7 and Nav1.8 antagonists, respectively, on thermal hyperalgesia in a painful diabetic neuropathy model of mice. Intrathecal administration of ProTx-II at doses from 0.04 to 4 ng to diabetic mice dose-dependently and significantly increased the tail-flick latency. Intrathecal administration of A803467 at doses from 10 to 100 ng to diabetic mice also dose-dependently and significantly increased the tail-flick latency. However, intrathecal administration of either ProTx-II (4 ng) or A803467 (100 ng) had no effect on the tail-flick latency in nondiabetic mice. The expression of either the Nav1.7 or Nav1.8 sodium channel protein in the dorsal root ganglion in diabetic mice was not different from that in nondiabetic mice. The present results suggest that ProTx-II and A803467, highly selective blockers of Nav1.7 and Nav1.8 sodium channels, respectively, in the spinal cord, can have antihyperalgesic effects in diabetic mice.

  15. Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA

    PubMed Central

    Rivera-Torres, Iván O.; Jin, Tony B.; Cadene, Martine; Chait, Brian T.; Poget, Sébastien F.

    2016-01-01

    Due to their central role in essential physiological processes, potassium channels are common targets for animal toxins. These toxins in turn are of great value as tools for studying channel function and as lead compounds for drug development. Here, we used a direct toxin pull-down assay with immobilised KcsA potassium channel to isolate a novel KcsA-binding toxin (called Tx7335) from eastern green mamba snake (Dendroaspis angusticeps) venom. Sequencing of the toxin by Edman degradation and mass spectrometry revealed a 63 amino acid residue peptide with 4 disulphide bonds that belongs to the three-finger toxin family, but with a unique modification of its disulphide-bridge scaffold. The toxin induces a dose-dependent increase in both open probabilities and mean open times on KcsA in artificial bilayers. Thus, it unexpectedly behaves as a channel activator rather than an inhibitor. A charybdotoxin-sensitive mutant of KcsA exhibits similar susceptibility to Tx7335 as wild-type, indicating that the binding site for Tx7335 is distinct from that of canonical pore-blocker toxins. Based on the extracellular location of the toxin binding site (far away from the intracellular pH gate), we propose that Tx7335 increases potassium flow through KcsA by allosterically reducing inactivation of the channel. PMID:27044983

  16. Registration of high-oleic peanut germplasm line ARSOK-S1 (TX996784) with enhanced resistance to Sclerotinia blight and pod rot

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The high oleic Spanish peanut (Arachis hypogaea L. subsp. fastigiata var. vulgaris) germplasm line ARSOK-S1 was developed cooperatively between the USDA Agricultural Research Service, Texas AgriLife Research, and Oklahoma State University, and was released in 2013. ARSOK-S1 (tested early as TX99678...

  17. EPA Proposes to Add Burnet Co., TX, Groundwater Plume to National Priorities List of Superfund Sites, Two hazardous waste sites added, six proposed nationally

    EPA Pesticide Factsheets

    (DALLAS - March 24, 2015) The Environmental Protection Agency (EPA) proposed to add the Main Street Groundwater Plume site in Burnet Co., TX, to the National Priorities List (NPL) of Superfund sites, a list of sites that pose risks to people's healt

  18. EPA Adds Burnet Co., TX, Groundwater Plume to National Priorities List of Superfund Sites, Five hazardous waste sites added, seven proposed nationally

    EPA Pesticide Factsheets

    (DALLAS - Sept. 28, 2015) The Environmental Protection Agency (EPA) added the Main Street Groundwater Plume site in Burnet Co., TX, to the National Priorities List (NPL) of Superfund sites, a list of sites that pose risks to people's health and the

  19. Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Wellman, TX, Six-Month Evaluation Report

    EPA Science Inventory

    This report documents the activities performed and the results obtained from the first six months of the arsenic removal treatment technology demonstration project in the City of Wellman, TX. The main objective of the project was to evaluate the effectiveness of AdEdge Technolog...

  20. ARSENIC REMOVAL FROM DRINKING WATER BY ADSORPTIVE MEDIA U.S. EPA DEMONSTRATION PROJECT AT BRUNI, TX, SIX-MONTH EVALUATION REPORT

    EPA Science Inventory

    This report documents the activities performed and the results obtained from the first six months of the arsenic removal treatment technology demonstration project at the Webb Consolidated Independent School District (Webb CISD) site at Bruni, TX. The main objective of the projec...

  1. Electrochemical and in-situ X-ray diffraction studies of Ti3C2Tx MXene in ionic liquid electrolyte

    DOE PAGES

    Lin, Zifeng; Rozier, Patrick; Duployer, Benjamin; ...

    2016-08-26

    2D titanium carbide (Ti3C2Tx MXene) showed good capacitance in both organic and neat ionic liquid electrolytes, but its charge storage mechanism is still not fully understood. Here, electrochemical characteristics of Ti3C2Tx electrode were studied in neat EMI-TFSI electrolyte. A capacitive behavior was observed within a large electrochemical potential range (from – 1.5 to 1.5 V vs. Ag). Intercalation and de-intercalation of EMI+ cations and/or TFSI– anions were investigated by in-situ X-ray diffraction. Interlayer spacing of Ti3C2Tx flakes decreases during positive polarization, which can be ascribed to either electrostatic attraction effect between intercalated TFSI– anions and positively charged Ti3C2Tx nanosheets ormore » steric effect caused by de-intercalation of EMI+ cations. In conclusion, the expansion of interlayer spacing when polarized to negative potentials is explained by steric effect of cation intercalation.« less

  2. 78 FR 63867 - Change of Using Agency for Restricted Areas R-5115, NM, and R-6316, R-6317, and R-6318, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Federal Aviation Administration 14 CFR Part 73 RIN 2120-AA66 Change of Using Agency for Restricted Areas R-5115, NM, and R- 6316, R-6317, and R-6318, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action updates the name of the using agencies for Restricted Areas...

  3. Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Webb Consolidated Independent School District in Bruni, TX - Final Performance Evaluation Report

    EPA Science Inventory

    This report documents the activities performed and the results obtained from the arsenic removal treatment technology demonstration project at the Webb Consolidated Independent School District (Webb CISD) in Bruni, TX. The main objective of the project was to evaluate the effect...

  4. The effect of water on the microstructure of 1-butyl-3-methylimidazolium tetrafluoroborate/TX-100/benzene ionic liquid microemulsions.

    PubMed

    Gao, Yan'an; Li, Na; Zheng, Liqiang; Zhao, Xueyan; Zhang, Jin; Cao, Quan; Zhao, Mingwei; Li, Zhen; Zhang, Gaoyong

    2007-01-01

    The ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) forms nonaqueous microemulsions with benzene with the aid of nonionic surfactant TX-100. The phase diagram of the ternary system was prepared, and the microstructures of the microemulsion were recognized. On the basis of the phase diagram, a series of ionic liquid-in-oil (IL/O) microemulsions were chosen and characterized by dynamic light scattering (DLS), which shows a similar swelling behavior to typical water-in-oil (W/O) microemulsions. The existence of IL pools in the IL/O microemulsion was confirmed by UV/Vis spectroscopic analysis with CoCl2 and methylene blue (MB) as the absorption probes. A constant polarity of the IL pool is observed, even if small amounts of water are added to the microemulsion, thus suggesting that the water molecules are solubilized in the polar outer shell of the microemulsion, as confirmed by FTIR spectra. 1H NMR spectroscopic analysis shows that these water molecules interact with the electronegative oxygen atoms of the oxyethylene (OE) units of TX-100 through hydrogen-bonding interactions, and the electronegative oxygen atoms of the water molecules attract the electropositive imidazolium rings of [bmim][BF4]. Hence, the water molecules are like a glue that stick the IL and OE units more tightly together and thus make the microemulsion system more stable. Considering the unique solubilization behavior of added water molecules, the IL/O microemulsion system may be used as a medium to prepare porous or hollow nanomaterials by hydrolysis reactions.

  5. Role of solubilized water in the reverse ionic liquid microemulsion of 1-butyl-3-methylimidazolium tetrafluoroborate/TX-100/benzene.

    PubMed

    Gao, Yan'an; Li, Na; Zheng, Liqiang; Bai, Xiangtao; Yu, Li; Zhao, Xueyan; Zhang, Jin; Zhao, Mingwei; Li, Zhen

    2007-03-15

    The ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate (bmimBF4) can form nonaqueous microemulsions with benzene by the aid of nonionic surfactant TX-100. The effect of water on ionic liquid-in-oil (IL/O) microemulsions was studied, and it was shown that the addition of small amount of water to the IL microemulsion contributed to the stability of microemulsion and thus increased the amount of solubilized bmimBF4 in the microemulsion. The conductivity measurements also showed that the attractive interactions between IL microdroplets were weakened, that is, the IL/O microemulsion becomes more stable in the present of some water. Fourier transform IR was carried out to analyze the states of the added water, and the result showed that these water molecules mainly behaved as bound water and trapped water, indicating that the water molecules are located in the palisade layers of the IL/O microemulsion. Furthermore, 1H NMR and 19F NMR spectra suggested that the added water molecules built the hydrogen binding network of imidazolium cations and H2O, BF4- anion and H2O, and at the same time the electronegative oxygen atoms of the oxyethylene units of TX-100 and water in the palisade layers, which made the palisade layers more firm and thus increased the stability of the microemulsion. The study can help in further understanding the formation mechanism of microemulsions. In addition, the characteristic solubilization behavior of the added water can provide an aqueous interface film for hydrolysis reactions and therefore may be used as an ideal medium to prepare porous or hollow nanomaterials.

  6. The neuromuscular activity of Bothriopsis bilineata smaragdina (forest viper) venom and its toxin Bbil-TX (Asp49 phospholipase A2) on isolated mouse nerve-muscle preparations.

    PubMed

    Floriano, Rafael Stuani; Rocha, Thalita; Carregari, Victor Corasolla; Marangoni, Sergio; da Cruz-Höfling, Maria Alice; Hyslop, Stephen; Rodrigues-Simioni, Léa; Rowan, Edward G

    2015-03-01

    The presynaptic action of Bothriopsis bilineata smaragdina (forest viper) venom and Bbil-TX, an Asp49 PLA2 from this venom, was examined in detail in mouse phrenic nerve-muscle (PND) preparations in vitro and in a neuroblastoma cell line (SK-N-SH) in order to gain a better insight into the mechanism of action of the venom and associated Asp49 PLA2. In low Ca(2+) solution, venom (3μg/ml) caused a quadriphasic response in PND twitch height whilst at 10μg/ml the venom additionally induced an abrupt and marked initial contracture followed by neuromuscular facilitation, rhythmic oscillations of nerve-evoked twitches, alterations in baseline and progressive blockade. The venom slowed the relaxation phase of muscle twitches. In low Ca(2+), Bbil-TX [210nM (3μg/ml)] caused a progressive increase in PND twitch amplitude but no change in the decay time constant. Venom (10μg/ml) and Bbil-TX (210nM) caused minor changes in the compound action potential (CAP) amplitude recorded from sciatic nerve preparations, with no significant effect on rise time and latency; tetrodotoxin (3.1nM) blocked the CAP at the end of the experiments. In mouse triangularis sterni nerve-muscle (TSn-m) preparations, venom (10μg/ml) and Bbil-TX (210nM) significantly reduced the perineural waveform associated with the outward K(+) current while the amplitude of the inward Na(+) current was not significantly affected. Bbil-TX (210nM) caused a progressive increase in the quantal content of TSn-m preparations maintained in low Ca(2+) solution. Venom (3μg/ml) and toxin (210nM) increased the calcium fluorescence in SK-N-SH neuroblastoma cells loaded with Fluo3 AM and maintained in low or normal Ca(2+) solution. In normal Ca(2+), the increase in fluorescence amplitude was accompanied by irregular and frequent calcium transients. In TSn-m preparations loaded with Fluo4 AM, venom (10μg/ml) caused an immediate increase in intracellular Ca(2+) followed by oscillations in fluorescence and muscle contracture

  7. Somerset County Flood Information System

    USGS Publications Warehouse

    Summer, William M.

    1998-01-01

    IntroductionThe timely warning of a flood is crucial to the protection of lives and property. One has only to recall the flood of August 2, 1973, in Somerset County, New Jersey, in which six lives were lost and major property damage occurred, to realize how unexpected and costly, especially in terms of human life, a flood can be. Accurate forecasts and warnings cannot be made, however, without detailed information about precipitation and streamflow in the drainage basin.Recognizing the need for detailed hydrologic information for Somerset County, the U.S. Geological Survey (USGS), in cooperation with Somerset County, installed the Somerset County Flood Information System (SCFIS) in 1990. The availability of data provided by this system will improve the flood forecasting ability of the National Weather Service (NWS), and has assisted Somerset County and municipal agencies in planning and execution of flood-preparation and emergency evacuation procedures in the county.This fact sheet describes the Somerset County Flood Information System and identifies its benefits.

  8. The Effect of Prescribed Burns and Wildfire on Vegetation in Bastrop State Park, TX

    NASA Astrophysics Data System (ADS)

    Justice, C. J.

    2014-12-01

    In 2011, central Texas had its worst drought since the 1950's. This, in conjunction with the strong winds produced by Tropical Storm Lee created conditions that made possible the Bastrop County Complex Fire in September 2011. These record-breaking wildfires burned over 95% of the 6,565-acre Bastrop State Park (BSP). Since 2003, BSP had been using prescribed burns as a management practice to reduce fuel load and prevent high severity wildfires. Although these prescribed fires did not prevent the 2011 wildfires they may have mitigated their effects. This study considered the effect of prescribed burn history and wildfire burn severity on vegetation recovery in BSP since the 2011 wildfire. The hypotheses of this study are that prescribed burn history and wildfire burn severity separately and jointly have affected post wildfire vegetation. To test these hypotheses, data were collected in 2013 from 46 plots across BSP using the Fire Effects Monitoring and Inventory (FIREMON) protocol to determine herbaceous plant density, shrub density, overstory density, and midstory tree density. Data were analyzed using analyses of variance (ANOVA) to determine the effects of prescribed fire and wildfire severity on these vegetation measurements. It was found that more severely burned plots had more herbaceous plants, fewer midstory trees, and lower shrub densities than less severely burned plots. Contrary to an initial hypotheses, there were few relationships between prescribed burn history and wildfire effects. The only significant effect detected for prescribed burning was the positive effect of prescribed fire on midstory tree density, but only for plots that were not severely burned in the wildfire. In this system, burn severity had a greater effect on post-wildfire vegetation than prescribed burns.

  9. 32 CFR 1602.10 - County.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false County. 1602.10 Section 1602.10 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.10 County. The word county includes, where applicable, counties, independent cities, and similar...

  10. BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents.

    PubMed Central

    Huys, Isabelle; Xu, Chen-Qi; Wang, Cheng-Zhong; Vacher, Hélène; Martin-Eauclaire, Marie-France; Chi, Cheng-Wu; Tytgat, Jan

    2004-01-01

    A novel HERG channel blocker was isolated from the venom of the scorpion Buthus martensi Karsch, sequenced and characterized at the pharmacological level after chemical synthesis. According to the determined amino acid sequence, the cDNA and genomic genes were then cloned. The genomic gene consists of two exons interrupted by an intron of 65 bp at position -6 upstream from the mature toxin. The protein sequence of this toxin was completely identical with that of a known A-type K+ current blocker BmTx3, belonging to scorpion alpha-KTx subfamily 15. Thus BmTx3 is the first reported alpha-KTx peptide also showing HERG-blocking activity, like gamma-KTx peptides. Moreover, different from classical alpha-KTx peptides, such as charybdotoxin, BmTx3 cannot block Shaker -type K+ channels. Phylogenetic tree analysis reveals that this toxin takes an intermediate position between classical alpha-KTx and gamma-KTx toxins. From a structural point of view, we propose that two separate functional faces might exist on the BmTx3 molecule, responsible for the two different K+-current-blocking functions. Face A, composed of Arg18 and Lys19 in the alpha-helix side, might correspond to HERG blocking activity, whereas Face B, containing a putative functional dyad (Lys27 and Tyr36) in the beta-sheet side, might correspond to A-type blocking activity. A specific deletion mutant with the disrupted Face B, BmTx3-Y36P37del, loses the A-type current-blocking activity, but keeps a similar HERG-blocking activity, as seen with the wild-type toxin. PMID:14599291

  11. Comparison of hypoxic cell radiosensitizers, KIN-804, KIN-844, KIN-806 and TX-1877, on brain and liver metabolizing capacities in mice bearing Ehrlich ascites carcinoma.

    PubMed

    Abou-Bedair, Farid Ahmed; Hori, Hitoshi; Nagasawa, Hideko; Uto, Yoshihiro; Abu-Zeid, Medhat; Inayama, Seiichi

    2002-05-01

    The biochemical effects of the 2-nitroimidazole hypoxic cell radiosensitizers KIN-804, KIN-806, and their analogues KIN-844 and TX-1877 on brain acetylcholinesterase (AChE) and hepatic free radical scavenging systems, such as reduced glutathione (GSH) and glucose-6-phosphate dehydrogenase (G-6-PDH) levels, and hepatic antioxidants, such as superoxide dismutase (SOD) and catalase, were evaluated in Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The assay of brain AChE revealed nonsignificant changes with all drugs examined. To evaluate the hepatic metabolic capacity, groups of mice were divided into control, EAC-inoculated, 10-Gy local gamma-irradiated, and KIN-804, KIN-844, KIN-806, or TX-1877 (50 mg/kg body weight, i.p.) groups, and gamma-irradiation was combined with each drug. EAC inoculation markedly suppressed GSH, G-6-PDH, SOD, and catalase levels. On the other hand, treatment with gamma-irradiation significantly enhanced them. The treatment of EAC-bearing mice with each drug alone in the absence of gamma-irradiation revealed that KIN-806 and its derivative TX-1877 showed antitumor activity through their significant recovery of GSH and SOD levels, respectively, in the EAC-bearing mice group. Similarly, the combined treatment of EAC-bearing mice with gamma-irradiation with each of the drugs tested showed that KIN-806 and TX-1877 significantly increased GSH and SOD, and to a lesser extent G-6-PDH and catalase levels. On the other hand, KIN-804 and KIN-844 had only a nonsignificant effect on all parameters examined. In conclusion, these data reveal that the administration of KIN-806 and TX-1877 with or without subsequent gamma-irradiation, resulted in significant recovery of GSH and SOD activities that were inhibited by EAC inoculation.

  12. Results of Phase I groundwater quality assessment for single-shell tank waste management areas T and TX-TY at the Hanford Site

    SciTech Connect

    Hodges, F.N.

    1998-01-01

    Pacific Northwest National Laboratory (PNNL) conducted a Phase I, Resource Conservation and Recovery Act of 1976 (RCRA) groundwater quality assessment for the Richland Field Office of the U.S. Department of Energy (DOE-RL) under the requirements of the Federal Facility Compliance Agreement. The purpose of the investigation was to determine if the Single-Shell Tank Waste Management Areas (WMAs) T and TX-TY have impacted groundwater quality. Waste Management Areas T and TX-TY, located in the northern part of the 200 West Area of the Hanford Site, contain the 241-T, 241-TX, and 241-TY tank farms and ancillary waste systems. These two units are regulated under RCRA interim-status regulations (under 40 CFR 265.93) and were placed in assessment groundwater monitoring because of elevated specific conductance in downgradient wells. Anomalous concentrations of technetium-99, chromium, nitrate, iodine-129, and cobalt-60 also were observed in some downgradient wells. Phase I assessment, allowed under 40 CFR 265, provides the owner-operator of a facility with the opportunity to show that the observed contamination has a source other than the regulated unit. For this Phase I assessment, PNNL evaluated available information on groundwater chemistry and past waste management practices in the vicinity of WMAs T and TX-TY. Background contaminant concentrations in the vicinity of WMAs T and TX-TY are the result of several overlapping contaminant plumes resulting from past-practice waste disposal operations. This background has been used as baseline for determining potential WMA impacts on groundwater.

  13. Frederick County Green Homes Challenge

    EPA Pesticide Factsheets

    Frederick County, Maryland, is an EPA Climate Showcase Community. EPA’s Climate Showcase Communities Program helps local governments and tribal nations pilot innovative, cost-effective and replicable community-based greenhouse gas reduction projects.

  14. Geothermal development plan: Yuma county

    SciTech Connect

    White, D.H.

    1981-01-01

    One hot spring and 33 wells drilled in the county discharge water at temperatures sufficient for direct-use geothermal applications such as process heat and space heating and cooling. Currently, one industry within the county has been identified which may be able to use geothermal energy for its process heat requirements. Also, a computer simulation model was used to predict geothermal energy on line as a function of time under both private and city-owned utility development of the resource.

  15. Vitamin D analogue TX 527 down-regulates the NF-κB pathway and controls the proliferation of endothelial cells transformed by Kaposi sarcoma herpesvirus

    PubMed Central

    González-Pardo, V; Verstuyf, A; Boland, R; Russo de Boland, A

    2013-01-01

    Background and Purpose The Kaposi sarcoma (KS)-associated herpesvirus GPCR (vGPCR) is a key molecule in the pathogenesis of KS, where it increases NF-κB gene expression and activates the NF-κB pathway. We investigated whether the less calcemic vitamin D analogue TX 527 inhibited the proliferation of endothelial cells transformed by vGPCR by modulation of the NF-κB pathway. Experimental Approach Endothelial cells transformed by vGPCR (SVEC-vGPCR) were treated with TX 527. Proliferation was measured by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) and cell cycle by flow cytometry. mRNA and protein levels were measured by real-time quantitative reverse transcriptase-PCR (qRT-PCR) and immunoblot analysis respectively. Key Results TX 527, similar to bortezomib (0.5 nM), a proteasome inhibitor that inhibits the activation of NF-κB, reduced proliferation and induced G0/G1 cell cycle arrest in SVEC-vGPCR. TX 527 like 1α,25(OH)2D3, biological active form of vitamin D, decreased the activity of NF-κB comparable with the effect of bortezomib. Time-response studies showed that TX 527 significantly decreased NF-κB and increased IκBα mRNA and protein levels. The increase of IκBα was accompanied by a reduction in p65/NF-κB translocation to the nucleus. These responses were abolished when vitamin D receptor (VDR) expression was suppressed by stable transfection of shRNA against VDR. In parallel with NF-κB inhibition, there was a down-regulation of inflammatory genes such as IL-6, CCL2/MCP and CCL20/MIP3α. Conclusions and Implications These results suggest that the anti-proliferative effects of the vitamin D analogue TX 527 in SVEC-vGPCR occur by modulation of the NF-κB pathway and are VDR dependent. PMID:23647513

  16. Differential effects of the recombinant toxin PnTx4(5-5) from the spider Phoneutria nigriventer on mammalian and insect sodium channels.

    PubMed

    Paiva, Ana L B; Matavel, Alessandra; Peigneur, Steve; Cordeiro, Marta N; Tytgat, Jan; Diniz, Marcelo R V; de Lima, Maria Elena

    2016-02-01

    The toxin PnTx4(5-5) from the spider Phoneutria nigriventer is extremely toxic/lethal to insects but has no macroscopic behavioral effects observed in mice after intracerebral injection. Nevertheless, it was demonstrated that it inhibits the N-methyl-d-aspartate (NMDA) - subtype of glutamate receptors of cultured rat hippocampal neurons. PnTx4(5-5) has 63% identity to PnTx4(6-1), another insecticidal toxin from P. nigriventer, which can slow down the sodium current inactivation in insect central nervous system, but has no effect on Nav1.2 and Nav1.4 rat sodium channels. Here, we have cloned and heterologous expressed the toxin PnTx4(5-5) in Escherichia coli. The recombinant toxin rPnTx4(5-5) was tested on the sodium channel NavBg from the cockroach Blatella germanica and on mammalian sodium channels Nav1.2-1.6, all expressed in Xenopus leavis oocytes. We showed that the toxin has different affinity and mode of action on insect and mammalian sodium channels. The most remarkable effect was on NavBg, where rPnTx4(5-5) strongly slowed down channel inactivation (EC50 = 212.5 nM), and at 1 μM caused an increase on current peak amplitude of 105.2 ± 3.1%. Interestingly, the toxin also inhibited sodium current on all the mammalian channels tested, with the higher current inhibition on Nav1.3 (38.43 ± 8.04%, IC50 = 1.5 μM). Analysis of activation curves on Nav1.3 and Nav1.5 showed that the toxin shifts channel activation to more depolarized potentials, which can explain the sodium current inhibition. Furthermore, the toxin also slightly slowed down sodium inactivation on Nav1.3 and Nav1.6 channels. As far as we know, this is the first araneomorph toxin described which can shift the sodium channel activation to more depolarized potentials and also slows down channel inactivation.

  17. 1. Historic American Buildings Survey Colusa County Chamber of Commerce ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Colusa County Chamber of Commerce Booklet - Album of the 'County of Good Luck' Original: 1908 Re-photo: September 1940 - Hall of Records & County Jail, Colusa, Colusa County, CA

  18. Population substructure in Cache County, Utah: the Cache County study

    PubMed Central

    2014-01-01

    Background Population stratification is a key concern for genetic association analyses. In addition, extreme homogeneity of ethnic origins of a population can make it difficult to interpret how genetic associations in that population may translate into other populations. Here we have evaluated the genetic substructure of samples from the Cache County study relative to the HapMap Reference populations and data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Results Our findings show that the Cache County study is similar in ethnic diversity to the self-reported "Whites" in the ADNI sample and less homogenous than the HapMap CEU population. Conclusions We conclude that the Cache County study is genetically representative of the general European American population in the USA and is an appropriate population for conducting broadly applicable genetic studies. PMID:25078123

  19. Somerset County Flood Information System

    USGS Publications Warehouse

    Hoppe, Heidi L.

    2007-01-01

    The timely warning of a flood is crucial to the protection of lives and property. One has only to recall the floods of August 2, 1973, September 16 and 17, 1999, and April 16, 2007, in Somerset County, New Jersey, in which lives were lost and major property damage occurred, to realize how costly, especially in terms of human life, an unexpected flood can be. Accurate forecasts and warnings cannot be made, however, without detailed information about precipitation and streamflow in the drainage basin. Since the mid 1960's, the National Weather Service (NWS) has been able to forecast flooding on larger streams in Somerset County, such as the Raritan and Millstone Rivers. Flooding on smaller streams in urban areas was more difficult to predict. In response to this problem the NWS, in cooperation with the Green Brook Flood Control Commission, installed a precipitation gage in North Plainfield, and two flash-flood alarms, one on Green Brook at Seeley Mills and one on Stony Brook at Watchung, in the early 1970's. In 1978, New Jersey's first countywide flood-warning system was installed by the U.S. Geological Survey (USGS) in Somerset County. This system consisted of a network of eight stage and discharge gages equipped with precipitation gages linked by telephone telemetry and eight auxiliary precipitation gages. The gages were installed throughout the county to collect precipitation and runoff data that could be used to improve flood-monitoring capabilities and flood-frequency estimates. Recognizing the need for more detailed hydrologic information for Somerset County, the USGS, in cooperation with Somerset County, designed and installed the Somerset County Flood Information System (SCFIS) in 1990. This system is part of a statewide network of stream gages, precipitation gages, weather stations, and tide gages that collect data in real time. The data provided by the SCFIS improve the flood forecasting ability of the NWS and aid Somerset County and municipal agencies in

  20. Headspace vapor characterization of Hanford Waste Tank 241-TX-111: Results from samples collected on October 12, 1995. Tank Vapor Characterization Project

    SciTech Connect

    Pool, K.H.; Clauss, T.W.; Evans, J.C.

    1996-06-01

    This report describes the results of vapor samples taken from the headspace of waste storage tank 241-TX-111 (Tank TX-111) at the Hanford Site in Washington State. Pacific Northwest National Laboratory (PNNL) contracted with Westinghouse Hanford Company (WHC) to provide sampling devices and analyze samples for inorganic and organic analytes collected from the tank headspace and ambient air near the tank. The analytical work was performed by the PNNL Vapor Analytical Laboratory (VAL) by the Tank Vapor Characterization Project. Work performed was based on a sample and analysis plan (SAP) prepared by WHC. The SAP provided job-specific instructions for samples, analyses, and reporting. The SAP for this sample job was {open_quotes}Vapor Sampling and Analysis Plan{close_quotes}, and the sample job was designated S5069. Samples were collected by WHC on October 12, 1995, using the Vapor Sampling System (VSS), a truck-based sampling method using a heated probe inserted into the tank headspace.

  1. Geothermal development plan: Yuma County

    SciTech Connect

    White, D.H.; Goldstone, L.A.

    1982-08-01

    The Yuma County Area Development Plan evaluated the county-wide market potential for utilizing geothermal energy. The study identified four potential geothermal resource areas with temperatures less than 90/sup 0/C (194/sup 0/F), and in addition, two areas are inferred to contain geothermal resources with intermediate (90/sup 0/C to 150/sup 0/C, 194/sup 0/F to 300/sup 0/F) temperature potential. The resource areas are isolated, although one resource area is located near Yuma, Arizona. One resource site is inferred to contain a hot dry rock resource. Anticipated population growth in the county is expected to be 2 percent per year over the next 40 years. The primary employment sector is agriculture, though some light industry is located in the county. Water supplies are found to be adequate to support future growth without advese affect on agriculture. Six firms were found in Yuma County which may be able to utilize geothermal energy for process heat needs. In addition, several agricultural processors were found, concentrated in citrus processing and livestock raising. Geothermal energy utilization projections suggest that by the year 2000, geothermal energy may economically provide the energy equivalent of 53,000 barrels of oil per year to the industrial sector if developed privately. Geothermal utilization projections increase to 132,000 barrels of oil per year by 2000 if a municipal utility developed the resource.

  2. Impacts of Near-term Climate Change on Surface Water - Groundwater Availability in the Nueces River basin, TX

    NASA Astrophysics Data System (ADS)

    Sinha, T.; Kumar, M.

    2014-12-01

    In arid and semi-arid regions, sustainability of surface water and groundwater resources is highly uncertain in the face of climate change as well as under competing demands due to urbanization, population growth and water needs to support ecosystem services. Most studies on climate change impact assessment focus on either surface water or groundwater resources alone. In this study, we utilize a fully coupled surface water and groundwater model, Penn-State Integrated Hydrologic Model (PIHM), and recent climate change projections from Climate Models Inter-comparison Project-5 (CMIP5) to evaluate impacts of near-term climate change on water availability in the Nueces River basin, TX. After performing calibration and validation of PIHM over multiple sites, hindcast simulations will be performed over the 1981-2010 period using data from multiple General Circulation Models (GCMs) obtained from the CMIP5 Project. The results will be compared to the observed data to understand added utility of hindcasts in improving the estimation of surface water and groundwater resources. Finally, we will assess the impacts of climate change on both surface water and groundwater resources over the next 20-30 years, which is a relevant time period for water management decisions.

  3. Spread of vaccinia virus through shaving during military training, Joint Base San Antonio-Lackland, TX, June 2014.

    PubMed

    Webber, Bryant J; Montgomery, Jay R; Markelz, Ana E; Allen, Kahtonna C; Hunninghake, John C; Ritchie, Simon A; Pawlak, Mary T; Johnston, Lindsay A; Oliver, Tiffany A; Winterton, Brad S

    2014-08-01

    Although naturally occurring smallpox virus was officially declared eradicated in 1980, concern for biological warfare prompted the U.S. Government in 2002 to recommend smallpox vaccination for select individuals. Vaccinia, the smallpox vaccine virus, is administered into the skin, typically on the upper arm, where the virus remains viable and infectious until the scab falls off and the epidermis is fully intact - typically 2-4 weeks. Adverse events following smallpox vaccination may occur in the vaccinee, in individuals who have contact with the vaccinee (i.e., secondary transmission), or in individuals who have contact with the vaccinee's contact (i.e., tertiary transmission). In June 2014 at Joint Base San Antonio-Lackland, TX, two cases of inadvertent inoculation of vaccinia and one case of a non-viral reaction following vaccination occurred in the security forces training squadron. This includes the first reported case of shaving as the likely source of autoinoculation after contact transmission. This paper describes the diagnosis and treatment of these cases, the outbreak investigation, and steps taken to prevent future transmission.

  4. Structural and Phylogenetic Studies with MjTX-I Reveal a Multi-Oligomeric Toxin – a Novel Feature in Lys49-PLA2s Protein Class

    PubMed Central

    Cavalcante, Walter L. G.; Fernandez, Roberto M.; Gallacci, Márcia; Soares, Andreimar M.; Oliveira, Cristiano L. P.; Fontes, Marcos R. M.

    2013-01-01

    The mortality caused by snakebites is more damaging than many tropical diseases, such as dengue haemorrhagic fever, cholera, leishmaniasis, schistosomiasis and Chagas disease. For this reason, snakebite envenoming adversely affects health services of tropical and subtropical countries and is recognized as a neglected disease by the World Health Organization. One of the main components of snake venoms is the Lys49-phospholipases A2, which is catalytically inactive but possesses other toxic and pharmacological activities. Preliminary studies with MjTX-I from Bothrops moojeni snake venom revealed intriguing new structural and functional characteristics compared to other bothropic Lys49-PLA2s. We present in this article a comprehensive study with MjTX-I using several techniques, including crystallography, small angle X-ray scattering, analytical size-exclusion chromatography, dynamic light scattering, myographic studies, bioinformatics and molecular phylogenetic analyses.Based in all these experiments we demonstrated that MjTX-I is probably a unique Lys49-PLA2, which may adopt different oligomeric forms depending on the physical-chemical environment. Furthermore, we showed that its myotoxic activity is dramatically low compared to other Lys49-PLA2s, probably due to the novel oligomeric conformations and important mutations in the C-terminal region of the protein. The phylogenetic analysis also showed that this toxin is clearly distinct from other bothropic Lys49-PLA2s, in conformity with the peculiar oligomeric characteristics of MjTX-I and possible emergence of new functionalities inresponse to environmental changes and adaptation to new preys. PMID:23573271

  5. Microemulsions with surfactant TX100, cyclohexane, and an ionic liquid investigated by conductance, DLS, FTIR measurements, and study of solvent and rotational relaxation within this microemulsion.

    PubMed

    Pramanik, Rajib; Sarkar, Souravi; Ghatak, Chiranjib; Rao, Vishal Govind; Setua, Palash; Sarkar, Nilmoni

    2010-06-10

    Room-temperature ionic liquids (RTILs), N,N,N-trimethyl-N-propyl ammonium bis(trifluoromethanesulfonyl) imide ([N(3111)][Tf(2)N]), were substituted for polar water and formed nonaqueous microemulsions with cyclohexane by the aid of nonionic surfactant TX-100. The phase behavior of the ternary system was investigated, and microregions of [N(3111)][Tf(2)N]-in-cyclohexane (IL/O), bicontinuous, and cyclohexane-in-[N(3111)][Tf(2)N] (O/IL) were identified by traditional electrical conductivity measurements. Dynamic light scattering (DLS) revealed the formation of the IL microemulsions. The FTIR study of O-H stretching band of TX100 also supports this finding. The dynamics of solvent and rotational relaxation have been investigated in [N(3111)][Tf(2)N]/TX100/cyclohexane microemulsions using steady-state and time-resolved fluorescence spectroscopy as a tool and coumarin 480 (C-480) as a fluorescence probe. The size of the microemulsions increases with gradual addition of [N(3111)][Tf(2)N], which revealed from DLS measurement. This leads to the faster collective motions of cation and anions of [N(3111)][Tf(2)N], which contributes to faster solvent relaxation in microemulsions.

  6. Intermediate valence to heavy fermion through a quantum phase transition in Yb3(Rh1-xTx)4Ge13 (T = Co, Ir) single crystals

    NASA Astrophysics Data System (ADS)

    Rai, Binod; Morosan, Emilia

    Single crystals of Yb3(Rh1-x Tx)4Ge13 (T = Co, Ir) have been grown using the self-flux method. Powder X-ray diffraction data on these compounds are consistent with the cubic structure with space group Pm 3 n . Intermediate valence behavior is observed in Yb3(Rh1-x Tx)4Ge13 upon T = Co doping, while T = Ir doping drives the system into a heavy fermion state. Antiferromagnetic order is observed in the Ir-doped samples Yb3(Rh1-x Tx)4Ge13 for 0.5 < x <= 1 with TN = 0.96 K for Yb3Ir4Ge13. With decreasing x, the magnetic order is suppressed towards a quantum critical point around xc = 0.5, accompanied by non-Fermi liquid behavior evidenced by logarithmic divergence of the specific heat and linear temperature dependence of the resistivity. The Fermi liquid behavior is recovered with the application of large magnetic fields. Gordon and Betty Moore Foundation EPiQS initiative through Grant GBMF4417 and Welch Foundation.

  7. Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.

    PubMed

    Ferreira, Ana Filipa; Ponte, Filipa; Silva, Renata; Rocha-Pereira, Carolina; Sousa, Emília; Pinto, Madalena; Bastos, Maria de Lourdes; Remião, Fernando

    2017-02-01

    A simple, rapid and economical method was developed and validated for the analysis and quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a P-glycoprotein inducer/activator, in biological samples, using reverse-phase high-performance liquid chromatography (HPLC). A C18 column and a mobile phase composed of methanol-water (90/10, v/v) with 1% (v/v) triethylamine, at a flow rate of 1 mL/min, were used for chromatographic separation. TX5 standards (0.5-150 μm) were prepared in human serum. Methanol was used for TX5 extraction and serum protein precipitation. After filtration, samples were injected into the HPLC apparatus and TX5 was quantified by a conventional UV detector at 255 nm. The TX5 retention time was 13 min in this isocratic system. The method was validated according to ICH guidelines for specificity/selectivity, linearity, accuracy, precision, limits of detection and quantification (LOD and LOQ) and recovery. The method was proved to be selective, as there were no interferences of endogenous compounds with the same retention time of TX5. Also, the developed method was linear (r(2)  ≥ 0.99) for TX5 concentrations between 0.5 and 150 μm and the LOD and LOQ were 0.08 and 0.23 μm, respectively. The results indicated that the reported method could meet the requirements for TX5 analysis in the trace amounts expected to be present in biological samples.

  8. Archuleta County CO Lineaments

    DOE Data Explorer

    Zehner, Richard E.

    2012-01-01

    Citation Information: Originator: Earth Science &Observation Center (ESOC), CIRES, University of Colorado at Boulder Originator: Geothermal Development Associates, Reno, Nevada Publication Date: 2012 Title: Archuleta Lineaments Edition: First Publication Information: Publication Place: Reno Nevada Publisher: Geothermal Development Associates, Reno, Nevada Description: This layer traces apparent topographic and air-photo lineaments in the area around Pagosa springs in Archuleta County, Colorado. It was made in order to identify possible fault and fracture systems that might be conduits for geothermal fluids. Geothermal fluids commonly utilize fault and fractures in competent rocks as conduits for fluid flow. Geothermal exploration involves finding areas of high near-surface temperature gradients, along with a suitable “plumbing system” that can provide the necessary permeability. Geothermal power plants can sometimes be built where temperature and flow rates are high. To do this, georeferenced topographic maps and aerial photographs were utilized in an existing GIS, using ESRI ArcMap 10.0 software. The USA_Topo_Maps and World_Imagery map layers were chosen from the GIS Server at server.arcgisonline.com, using a UTM Zone 13 NAD27 projection. This line shapefile was then constructed over that which appeared to be through-going structural lineaments in both the aerial photographs and topographic layers, taking care to avoid manmade features such as roads, fence lines, and right-of-ways. These lineaments may be displaced somewhat from their actual location, due to such factors as shadow effects with low sun angles in the aerial photographs. Note: This shape file was constructed as an aid to geothermal exploration in preparation for a site visit for field checking. We make no claims as to the existence of the lineaments, their location, orientation, and nature. Spatial Domain: Extent: Top: 4132831.990103 m Left: 311979.997741 m Right: 331678.289280 m Bottom: 4116067

  9. Misexpression of AtTX12 encoding a Toll/interleukin-1 receptor domain induces growth defects and expression of defense-related genes partially independently of EDS1 in Arabidopsis

    PubMed Central

    Song, Sang-Kee

    2016-01-01

    In this study, a tissue-specific GAL4/UAS activation tagging system was used for the characterization of genes which could induce lethality when ubiquitously expressed. A dominant mutant exhibiting stunted growth was isolated and named defective root development 1-D (drd1-D). The T-DNA tag was located within the promoter region of AtTX12, which is predicted to encode a truncated nucleotide-binding leucine-rich repeat (NLR) protein, containing a Toll/interleukin-1 receptor (TIR) domain. The transcript levels of AtTX12 and defense-related genes were elevated in drd1-D, and the misexpression of AtTX12 recapitulated the drd1-D phenotypes. In the presence of ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), a key transducer of signals triggered by TIR-type NLRs, a low-level of AtTX12 misexpression induced strong defective phenotypes including seedling lethality whereas, in the absence of EDS1, a high-level of AtTX12 misexpression induced weak growth defects like dwarfism, suggesting that AtTX12 might function mainly in an EDS1-dependent and partially in an EDS1-independent manner. [BMB Reports 2016; 49(12): 693–698] PMID:27802841

  10. Johnson County Business and Industry Training Needs.

    ERIC Educational Resources Information Center

    Johnson County Community Coll., Overland Park, KS. Office of Institutional Research.

    In fall 1982, Johnson County Community College (JCCC) conducted two surveys to determine the internal training needs of business and industry in Johnson County. One survey was mailed to the chief executives of some 2,000 businesses and industries, and another was distributed to about 2,000 employees of a large corporation in the county. Study…

  11. Community Types and Mortality in Georgia Counties

    ERIC Educational Resources Information Center

    Young, Frank W.

    2012-01-01

    Using an "ecological regional analysis" methodology for defining types of communities and their associated mortality rates, this study of Georgia's 159 counties finds that the suburban and town centered counties have low mortality while the city-centered type predicts low mortality for the whites. The military-centered counties do not…

  12. Once Distressed, Jackson County Moves On.

    ERIC Educational Resources Information Center

    Baldwin, Fred D.

    1998-01-01

    In 1981, Jackson County, North Carolina, appeared on the first list of "distressed counties" in Appalachia. Since then, the rural county has made significant improvements by investing in its physical infrastructure (which also promotes tourism); fostering economic-development partnerships among governments, small businesses, and local…

  13. Low-Wage Counties Face Locational Disadvantages.

    ERIC Educational Resources Information Center

    Gibbs, Robert; Cromartie, John B.

    2000-01-01

    Small populations and remoteness are the most salient features of low-wage counties. These locational attributes coincide with fewer high-wage jobs, yet low wages within industries define low-wage counties more than industry composition. Although adults in low-wage counties have less education and labor force participation overall, the role played…

  14. Trouble Brewing in Orange County. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    Orange County will soon face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Orange County faces a total $41.2 billion liability for retiree benefits that are underfunded--including $9.4 billion for the county pension system and an estimated…

  15. 76 FR 13172 - Placer County Water Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... Energy Regulatory Commission Placer County Water Agency Notice of Application Tendered for Filing with... Filed: February 23, 2011 d. Applicant: Placer County Water Agency e. Name of Project: Middle Fork... Manager, Placer County Water Agency, 144 Ferguson Road, Auburn, CA 95603; Telephone: (530) 823-4490....

  16. Cell cycle arrest and apoptosis induced by 1α,25(OH)2D3 and TX 527 in Kaposi sarcoma is VDR dependent.

    PubMed

    González-Pardo, Verónica; Suares, Alejandra; Verstuyf, Annemieke; De Clercq, Pierre; Boland, Ricardo; de Boland, Ana Russo

    2014-10-01

    We have previously shown that 1α,25(OH)2-Vitamin D3 [1α,25(OH)2D3] and its less calcemic analog TX 527 inhibit the proliferation of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR) and this could be partially explained by the inhibition of the NF-κB pathway. In this work, we further explored the mechanism of action of both vitamin D compounds in Kaposi sarcoma. We investigated whether the cell cycle arrest and subsequent apoptosis of endothelial cells (SVEC) and SVEC transformed by vGPCR (SVEC-vGPCR) elicited by 1α,25(OH)2D3 and TX 527 were mediated by the vitamin D receptor (VDR). Cell cycle analysis of SVEC and SVEC-vGPCR treated with 1α,25(OH)2D3 (10nM, 48h) revealed that 1α,25(OH)2D3 increased the percentage of cells in the G0/G1 phase and diminished the percentage of cells in the S phase of the cell cycle. Moreover, the number of cells in the S phase was higher in SVEC-vGPCR than in SVEC due to vGPCR expression. TX 527 exerted similar effects on growth arrest in SVEC-vGPCR cells. The cell cycle changes were suppressed when the expression of the VDR was blocked by a stable transfection of shRNA against VDR. Annexin V-PI staining demonstrated apoptosis in both SVEC and SVEC-vGPCR after 1α,25(OH)2D3 and TX 527 treatment (10nM, 24h). Cleavage of caspase-3 detected by Western blot analysis was increased to a greater extent in SVEC than in SVEC-vGPCR cells, and this effect was also blocked in VDR knockdown cells. Altogether, these results suggest that 1α,25(OH)2D3 and TX 527 inhibit the proliferation of SVEC and SVEC-vGPCR and induce apoptosis by a mechanism that involves the VDR.

  17. Fresno County Mock Trial Competition.

    ERIC Educational Resources Information Center

    Fresno City Unified School District, CA.

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT: The Fresno County Office of Education and the Fresno Unified School District hosted the Mock Trial Competition. The state competition is sponsored by the Constitutional Rights Foundation, with cosponsorship from the California State Bar Association and the California Young Lawyer's Association. This…

  18. Kinship Care in Walton County.

    ERIC Educational Resources Information Center

    Charon, Sara L.; Nackerud, Larry

    1996-01-01

    The quality of life of maltreated children placed with relatives was examined through interviews with nine families in Walton County (Georgia) who had taken in related children. Over half of the children had experienced some improvement in home life, school performance, and their physical and mental status. Kinship care families indicated needs…

  19. San Diego County Literacy Report.

    ERIC Educational Resources Information Center

    Simon, June; And Others

    The Comprehensive Adult Student Assessment System (CASAS) database for San Diego County reported in this document includes demographic and reading appraisal data collected during 15 months through April 1990 for more than 60,000 students in 6 diverse programs. Some of the findings resulting from analysis of the database include the following: (1)…

  20. Somerset County Employer Needs Assessment.

    ERIC Educational Resources Information Center

    Rephann, Terance J.

    Allegany Community College in Cumberland, Maryland, conducted an employer assessment survey of Somerset County businesses during the winter of 1995 in order to provide evaluation data for planning and curriculum development for the secondary and postsecondary educational institutions. The survey was mailed to 760 establishments, with a 29 percent…

  1. Geothermal development plan: Pima County

    NASA Astrophysics Data System (ADS)

    White, D. H.; Goldstone, L. A.

    1982-08-01

    The Pima County Area Development evaluated the county-wide market potential for utilizing geothermal energy. Four potential geothermal resource areas with temperatures less than 1000 C (2120 F) were identified. In addition, one area is identified as having a temperature of 1470 F (2970 F). Geothermal resources are found to occur in Tecson where average population growth rates of two to three percent per year are expected over the next 40 years. Rapid growth in the manufacturing sector and the existence of major copper mines provide opportunities for the direct utilization of geothermal energy. However, available water supplies are identified as a major constraing to projected growth. A regional energy analysis, future predictions for energy consumption, and energy prices are given. Potential geothermal users in Pima County are identified and projections of maximum economic geothermal utilization are given. One hundred fifteen firms in 32 industrial classes have some potential for geothermal use are identified. In addition, 26 agribusiness firms were found in the county.

  2. Hydrogeology of Wood County, Wisconsin

    USGS Publications Warehouse

    Batten, W.G.

    1989-01-01

    The average rate of ground·water pumpage in Wood County in 1985 was 9.7 million gallons per day. Of this rate, about 6 million gallons per day is pumped from municipal-supply wells in seven communities.An additional 1.08 million gallons per day is pumped for agricultural irrigation.

  3. Southern Nevada Library Services; Serving Lincoln County, Nye County, Esmeralda County through the Clark County Library District: An Evaluation.

    ERIC Educational Resources Information Center

    Dalton, Phyllis I.

    An anecdotal review covers the first year of increased library service in Nye, Lincoln, and Esmeralda Counties, Nevada, under the Southern Nevada Library Services project funded by the Library Services and Construction Act. Using information from questionnaires and site visits, the extent of library services in each community in the area is…

  4. On the structure of hot gas in haloes: implications for the LX-TX relation and missing baryons

    NASA Astrophysics Data System (ADS)

    Sharma, Prateek; McCourt, Michael; Parrish, Ian J.; Quataert, Eliot

    2012-12-01

    We present one-dimensional models of the hot gas in dark matter haloes, which both predict the existence of cool cores and explain their structure. Our models are directly applicable to semi-analytic models of galaxy formation. We have previously argued that filaments of cold (˜104 K) gas condense out of the intracluster medium (ICM) in hydrostatic and thermal equilibrium when the ratio of the thermal instability time-scale to the free-fall time tTI/tff falls below 5-10. This criterion corresponds to an upper limit on the density of the ICM and motivates a model in which a density core forms wherever tTI/tff ≲ 10. Consistent with observations and numerical simulations, this model predicts larger and more tenuous cores for lower mass haloes - while the core density in a cluster may be as large as ˜0.1 cm-3, the core density in the Galactic halo should not exceed ˜10-4 cm-3. We can also explain the large densities in smaller mass haloes (galactic 'coronae') if we include the contribution of the central galaxy to the gravitational potential. Our models produce a favourable match to the observational X-ray luminosity-temperature (LX-TX) relation. For halo masses ≲1013 M⊙ the core size approaches the virial radius. Thus, most of the baryons in such haloes cannot be in the hot ICM, but either in the form of stars or in the form of hot gas beyond the virial radius. Because of the smaller mass in the ICM and much larger mass available for star formation, the majority of the baryons in low-mass haloes (≲1013 M⊙) can be expelled beyond the virial radius due to supernova feedback. This can account for the baryons 'missing' from low-mass haloes, such as the Galactic halo.

  5. Integrating Infrastructure-Relevant Climate Projections into City Planning: Learning from Boulder CO, Austin TX and Washington DC

    NASA Astrophysics Data System (ADS)

    Stoner, A. M. K.; Hayhoe, K.

    2015-12-01

    Over the coming century, climate change has the potential to impact infrastructure in many different ways, particularly in population-dense areas that depend on transportation and built environments. Many of these impacts may occur via changes in the frequency and magnitude of extremes: high and low temperature, heat waves, precipitation, coastal flooding, and storm events. Having a better idea of how the climate might change locally, both within the near future as well as toward the end of the century, can give city planners and engineers guidance when designing new structures and when repairing and fortifying existing components of buildings, bridges, highways, sewers, ports, etc. However, the type of event and the amount of damages that may be incurred are often highly specific to a given location. Over the last 10 years, we have worked with a broad range of cities, states, non-profit organizations, and federal agencies to integrate climate projections into ongoing resiliency, sustainability, and management processes. Drawing on that experience, we describe the broad steps in assimilating climate information into existing decision-making frameworks relevant to most applications, as well as highlighting many of the unique aspects of these analyses using examples from our most recent work with three very different cities - Austin TX, Boulder CO and Washington DC. From initial conversations with local experts to identify relevant thresholds to final integration of projected changes into the planning processes of these cities, these case studies highlight the utility of including future climate projections into infrastructure planning, the challenges to doing so, and the over-arching importance of communication and interaction between infrastructure experts, engineers, and scientists.

  6. The Impacts of Exposure to Environmental Risk on Physical and Mental Health in a Small Geographic Community in Houston, TX.

    PubMed

    Sansom, Garett; Parras, Juan; Parras, Ana; Nieto, Yudith; Arellano, Yvette; Berke, Philip; McDonald, Thomas; Shipp, Eva; Horney, Jennifer A

    2017-03-13

    Previous research has shown that communities with low average socioeconomic status (SES) and majority minority populations are more likely to be exposed to industrial buildings, waste facilities, and poor infrastructure compared to white communities with higher average SES. While some studies have demonstrated linkages between exposures to specific environmental contaminates within these communities and negative health outcomes, little research has analyzed the effects of environmental contaminants on the mental and physical health of these populations. A cross-sectional survey collected data from residents of Manchester, a small neighborhood in Houston, TX, that is characterized by industrial sites, unimproved infrastructure, nuisance flooding, and poor air quality. Our study (N = 109) utilized the 12 item Short Form Health Survey version 2 (SF12v2) to assess the general mental and physical health of the community. The community as a whole had reduced physical health scores compared to U.S. national averages. The time residents had lived in the neighborhood was also correlated with a reported reduction in physical health scores (r2 = 0.136; p-value <0.001). The association between time lived in the neighborhood and poorer health scores remained after adjusting for age, race, and gender (coef = -0.27, p-value <0.001). Mental health scores were within national averages and time spent living in the neighborhood did not appear to negatively impact respondent's mental health scores. These findings point to the need for more research to determine the potential for additive physical and mental health impacts in long-term residents in neighborhoods characterized by environmental justice issues.

  7. Focalyx Dx, Bx, Tx et Apps: A novel contemporary fusion paradigm for the management of prostate cancer.

    PubMed

    Bianco, F J; Martínez-Salamanca, J I

    2016-07-01

    FocalyxTM conceived as a response to emerging evidence data across numerous cancer lesions that questions current standard treatment approaches that too often lead to detrimental quality of life yet delivering limited survival benefit, especially in-lieu of advances in imaging technology applicable to cancer patients. The Focalyx paradigm aims to control cancer with improvement in quality of life. We initially devised 5 milestones: 1- Consistently optimize Prostate MRI imaging using the novel published protocols adopted as guidelines by societies such as the European Society of Urology and Radiology; 2- Evaluate fusion platform software solutions that existed; 3- Determine best fusión platform for Focalyx on practicality, precision, and workflow premises; 4- Evaluate commercially available FDA approved ablative technologies to implement our treatment vision; 5- Design a treatment option that can be performed in the office setting under local anesthesia, which would not impact negatively QOL outcomes of Prostate Cancer patients and seamless constant nonintrusive practical patient-physician interaction by the Focalyx app that facilitates follow up and provides early warning signals shall any change in the disease dynamics emerge. Prostate cancer was identified as the pilot disease for Focalyx to deliver a "GPS" like solution for the prostate gland that destroys identifiable disease without adverse effects such as: cancer anxiety, urinary incontinence, loss of erections and ejaculation. Since September of 2013, over 300 men have been accrued in NCT02381990- clintrials.gov evaluating the feasibility of our solutions for imaging (FocalyxDx), Biopsy (FocalyxBx) and Treatment (FocalyxTx). In this review we detail the tools available to achieve the Focalyx paradigm for men with Prostate Cancer.

  8. Impacts of cool cities on air quality: A preliminary modeling assessment for Nashville TN, Dallas TX and Atlanta GA

    SciTech Connect

    Taha, Haider

    1998-06-15

    Previous atmospheric modeling efforts that concentrated on the Los Angeles Basin suggested beneficial and significant air quality impacts from cool cities strategies. This paper discusses an extension of similar modeling efforts to three regions, Atlanta GA, Dallas - Ft. Worth TX, and Nashville TN, that experience smog and air quality problems. According to the older ozone air quality standard (120 ppb), these regions were classified as serious, moderate, and marginal, respectively, but may be out of compliance with respect to the newer, 80-ppb/8-hours standard. Results from this exploratory modeling work suggest a range of possible impacts on meteorological and air quality conditions. For example, peak ozone concentrations during each region's respective episode could be decreased by 1-6 ppb (conservative and optimistic scenarios, respectively) in Nashville, 5-15 ppb in Dallas - Fort Worth, and 5-12 ppb in Atlanta following implementation of cool cities. The reductions are generally smaller than those obtained from simulating the Los Angeles Basin but are still significant. In all regions, the simulations suggest, the net, domain-wide effects of cool cities are reductions in ozone mass and improvements in air quality. In Atlanta, Nashville, and Dallas, urban areas benefiting from reduced smog reach up to 8460, 7350, and 12870 km{sup 2} in area, respectively. Results presented in this paper should be taken as exploratory and preliminary. These will most likely change during a more comprehensive modeling study to be started soon with the support of the US Environmental Protection Agency. The main purpose of the present project was to obtain the initial data (emission inventories) for these regions, simulate meteorological conditions, and perform preliminary sensitivity analysis. In the future, additional regions will be simulated to assess the potential of cool cities in improving urban air quality.

  9. Resolving the structure of Ti3C2Tx MXenes through multilevel structural modeling of the atomic pair distribution function

    DOE PAGES

    Wesolowski, David J.; Wang, Hsiu -Wen; Page, Katharine L.; ...

    2015-12-08

    MXenes are a recently discovered family of two-dimensional (2D) early transition metal carbides and carbonitrides, which have already shown many attractive properties and a great promise in energy storage and many other applications. However, a complex surface chemistry and small coherence length has been an obstacle in some applications of MXenes, also limiting accuracy of predictions of their properties. In this study, we describe and benchmark a novel way of modeling layered materials with real interfaces (diverse surface functional groups and stacking order between the adjacent monolayers) against experimental data. The structures of three kinds of Ti3C2Tx MXenes (T standsmore » for surface terminating species, including O, OH, and F) produced under different synthesis conditions were resolved for the first time using atomic pair distribution function obtained by high-quality neutron total scattering. The true nature of the material can be easily captured with the sensitivity of neutron scattering to the surface species of interest and the detailed third-generation structure model we present. The modeling approach leads to new understanding of MXene structural properties and can replace the currently used idealized models in predictions of a variety of physical, chemical and functional properties of Ti3C2-based MXenes. Furthermore, the developed models can be employed to guide the design of new MXene materials with selected surface termination and controlled contact angle, catalytic, optical, electrochemical and other properties. We suggest that the multi-level structural modeling should form the basis for a generalized methodology on modeling diffraction and pair distribution function data for 2D and layered materials.« less

  10. Hydrogeology of Webb County, Texas

    USGS Publications Warehouse

    Lambert, Rebecca B.

    2004-01-01

    IntroductionWebb County, in semiarid South Texas on the U.S.-Mexico border, is a region confronted by increasing stresses on natural resources. Laredo (fig. 1), the largest city in Webb County (population 193,000 in 2000), was one of the 10 fastest-growing metropolitan areas in the country during 1990-2000 (Perry and Mackun, 2001). Commercial and industrial activities have expanded throughout the region to support the maquiladora industry (manufacturing plants in Mexico) along the border and other growth as a result of the passage of the North American Free Trade Agreement. The Rio Grande currently (2002) is the primary source of public water supply for Laredo and other cities along the border in Webb County (fig. 1). Other cities, such as Bruni and Mirando City in the southeastern part of the county, rely on ground-water supplies to meet municipal demands. Increased water demand associated with development and population growth in the region has increased the need for the City of Laredo and Webb County to evaluate alternative water sources to meet future demand. Possible options include (1) supplementing the surface-water supply with ground water, and (2) applying artificial storage and recovery (ASR) technology to recharge local aquifers. These options raise issues regarding the hydraulic capability of the aquifers to store economically substantial quantities of water, current or potential uses of the resource, and possible effects on the quality of water resulting from mixing ground water with alternative source waters. To address some of these issues, the U.S. Geological Survey (USGS), in cooperation with the City of Laredo, began a study in 1996 to assess the ground-water resources of Webb County. A hydrogeologic study was conducted to review and analyze available information on the hydrogeologic units (aquifers and confining units) in Webb County, to locate available wells in the region with water-level and water-quality information from the aquifers, and to

  11. Chester County ground-water atlas, Chester County, Pennsylvania

    USGS Publications Warehouse

    Ludlow, Russell A.; Loper, Connie A.

    2004-01-01

    Chester County encompasses 760 square miles in southeastern Pennsylvania. Groundwater- quality studies have been conducted in the county over several decades to address specific hydrologic issues. This report compiles and describes water-quality data collected during studies conducted mostly after 1990 and summarizes the data in a county-wide perspective. In this report, water-quality constituents are described in regard to what they are, why the constituents are important, and where constituent concentrations vary relative to geology or land use. Water-quality constituents are grouped into logical units to aid presentation: water-quality constituents measured in the field (pH, alkalinity, specific conductance, and dissolved oxygen), common ions, metals, radionuclides, bacteria, nutrients, pesticides, and volatile organic compounds.Waterquality constituents measured in the field, common ions (except chloride), metals, and radionuclides are discussed relative to geology. Bacteria, nutrients, pesticides, and volatile organic compounds are discussed relative to land use. If the U.S. Environmental Protection Agency (USEPA) or Chester County Health Department has drinkingwater standards for a constituent, the standards are included. Tables and maps are included to assist Chester County residents in understanding the water-quality constituents and their distribution in the county. Ground water in Chester County generally is of good quality and is mostly acidic except in the carbonate rocks and serpentinite, where it is neutral to strongly basic. Calcium carbonate and magnesium carbonate are major constituents of these rocks. Both compounds have high solubility, and, as such, both are major contributors to elevated pH, alkalinity, specific conductance, and the common ions. Elevated pH and alkalinity in carbonate rocks and serpentinite can indicate a potential for scaling in water heaters and household plumbing. Low pH and low alkalinity in the schist, quartzite, and

  12. Mineralogical analysis of two different kind of icy surfaces in the trans-neptunian belt, TNOs (50000) Quaoar and 2002 TX300

    NASA Astrophysics Data System (ADS)

    Pinilla-Alonso, N.; Licandro, J.; Campins, H.

    2004-11-01

    TNOs (50000) Quaoar and 2002 TX300 were observed in the framework of a long-term program to study the surface properties of TNOs, Centaurs and comet nuclei using the Italian 3.58 m Telescopio Nazionale Galileo (TNG) at "El Roque de los Muchachos" Observatory (La Palma, Spain). Near-infrared spectra of both TNOs and visible spectrum of 2002 TX300 were obtained. Combining our spectra and the visible spectrum of (50000) Quaoar done by Marchi et al. (2004, A&A, 408, 17), and using the simple one-dimensional geometrical-optics formulation by Shkuratov et al. (1999, Icarus 137, 235), the visible and near-infrared spectra covering the 0.5-2.4 μ m range of both TNOs are analyzed in order to obtain mineralogical information of their surfaces. A large fraction of big water ice particles is needed to reproduce the large absorption bands observed in both objects, while other component, may be methanol, is needed to reproduce the absorption around 2.2 μ m observed in Quaoar (also reported by Brown & Trujillo 2004, AJ in press). Quaoar surface is very red, and a large fraction of complex organics is needed to reproduce the slope and general shape of the spectrum. On the other hand, the neutral color of the surface of TX300 and the huge water ice absorption bands suggest a very low abundance of complex organics. The very different fraction of tholins and water ice in the surface of both objects is indicative either of a very different original composition or a different resurfacing history. The results are discussed in the framework of the different resurfacing models already proposed. This work was supported by the grants from the National Science Foundation and the NASA Planetary Astronomy program.

  13. SU-E-J-48: Imaging Origin-Radiation Isocenter Coincidence for Linac-Based SRS with Novalis Tx

    SciTech Connect

    Geraghty, C; Workie, D; Hasson, B

    2015-06-15

    Purpose To implement and evaluate an image-based Winston-Lutz (WL) test to measure the displacement between ExacTrac imaging origin and radiation isocenter on a Novalis Tx system using RIT V6.2 software analysis tools. Displacement between imaging and radiation isocenters was tracked over time. The method was applied for cone-based and MLC-based WL tests. Methods The Brainlab Winston-Lutz phantom was aligned to room lasers. The ExacTrac imaging system was then used to detect the Winston- Lutz phantom and obtain the displacement between the center of the phantom and the imaging origin. EPID images of the phantom were obtained at various gantry and couch angles and analyzed with RIT calculating the phantom center to radiation isocenter displacement. The RIT and Exactrac displacements were combined to calculate the displacement between imaging origin and radiation isocenter. Results were tracked over time. Results Mean displacements between ExacTrac origin and radiation isocenter were: VRT: −0.1mm ± 0.3mm, LNG: 0.5mm ± 0.2mm, LAT: 0.2mm ± 0.2mm (vector magnitude of 0.7 ± 0.2mm). Radiation isocenter was characterized by the mean of the standard deviations of the WL phantom displacements: σVRT: 0.2mm, σLNG: 0.4mm, σLAT: 0.6mm. The linac couch base was serviced to reduce couch walkout. This reduced σLAT to 0.2mm. These measurements established a new baseline of radiation isocenter-imaging origin coincidence. Conclusion The image-based WL test has ensured submillimeter localization accuracy using the ExacTrac imaging system. Standard deviations of ExacTrac-radiation isocenter displacements indicate that average agreement within 0.3mm is possible in each axis. This WL test is a departure from the tradiational WL in that imaging origin/radiation isocenter agreement is the end goal not lasers/radiation isocenter.

  14. Brookside Mills, Knox County, TN

    EPA Pesticide Factsheets

    Brookside Mills, located in Knox County, TN, was a textile mill that was founded in 1885 and at its peak employed over 1,000 people. Its former uses included fabric weaving, dying, and sewing operations. It was at some point a department store, and during a portion of its history, coal was used as an energy source. Weaving operations continued in some form at the Brookside factory until 1969. In 1996 the buildings were demolished.

  15. Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A2, AplTx-I, purified from Agkistrodon piscivorus leucostoma snake venom.

    PubMed

    Resende, L M; Almeida, J R; Schezaro-Ramos, R; Collaço, R C O; Simioni, L R; Ramírez, D; González, W; Soares, A M; Calderon, L A; Marangoni, S; da Silva, S L

    2017-03-01

    Phospholipases A2 (PLA2s) constitute a class of extensively studied toxins, isolated from snake venoms. Basic PLA2 isoforms mediate various toxicological effects, while the acidic isoforms generally have higher enzymatic activities, but do not promote evident toxic effects. The functions of these acidic isoforms in snake venoms are still not completely understood and more studies are needed to characterize the biological functions and diversification of acidic toxins in order to justify their abundant presence in these secretions. Recently, Lomonte and collaborators demonstrated, in a proteomic and toxicological study, high concentrations of PLA2s in the venom of Agkistrodon piscivorus leucostoma. We have, herein, purified and characterized an acidic PLA2 from this snake venom, denominated AplTx-I, in order to better understand its biochemical and structural characteristics, as well as its biological effects. AplTx-I was purified using two chromatographic steps, in association with enzymatic and biological assays. The acidic toxin was found to be one of the most abundant proteins in the venom of A. p. leucostoma; the protein was monomeric with a molecular mass of 13,885.8 Da, as identified by mass spectrometry ESI-TOF and electrophoresis. The toxin has similar primary and tridimensional structures to those of other acidic PLA2s, a theoretical and experimental isoelectric point of ≈5.12, and a calcium-dependent enzyme activity of 25.8985 nM/min/mg, with maximum values at 37 °C and pH 8.0. Despite its high enzymatic activity on synthetic substrate, AplTx-I did not induce high or significant myotoxic, coagulant, anticoagulant, edema, neuromuscular toxicity in mouse phrenic nerve-diaphragm preparations or antibacterial activities. Interestingly, AplTx-I triggered a high and selective neuromuscular toxicity in chick biventer cervicis preparations. These findings are relevant to provide a deeper understanding of the pharmacology, role and diversification of acidic

  16. Feasibility of using Geant4 Monte Carlo simulation for IMRT dose calculations for the Novalis Tx with a HD-120 multi-leaf collimator

    NASA Astrophysics Data System (ADS)

    Jung, Hyunuk; Shin, Jungsuk; Chung, Kwangzoo; Han, Youngyih; Kim, Jinsung; Choi, Doo Ho

    2015-05-01

    The aim of this study was to develop an independent dose verification system by using a Monte Carlo (MC) calculation method for intensity modulated radiation therapy (IMRT) conducted by using a Varian Novalis Tx (Varian Medical Systems, Palo Alto, CA, USA) equipped with a highdefinition multi-leaf collimator (HD-120 MLC). The Geant4 framework was used to implement a dose calculation system that accurately predicted the delivered dose. For this purpose, the Novalis Tx Linac head was modeled according to the specifications acquired from the manufacturer. Subsequently, MC simulations were performed by varying the mean energy, energy spread, and electron spot radius to determine optimum values of irradiation with 6-MV X-ray beams by using the Novalis Tx system. Computed percentage depth dose curves (PDDs) and lateral profiles were compared to the measurements obtained by using an ionization chamber (CC13). To validate the IMRT simulation by using the MC model we developed, we calculated a simple IMRT field and compared the result with the EBT3 film measurements in a water-equivalent solid phantom. Clinical cases, such as prostate cancer treatment plans, were then selected, and MC simulations were performed. The accuracy of the simulation was assessed against the EBT3 film measurements by using a gamma-index criterion. The optimal MC model parameters to specify the beam characteristics were a 6.8-MeV mean energy, a 0.5-MeV energy spread, and a 3-mm electron radius. The accuracy of these parameters was determined by comparison of MC simulations with measurements. The PDDs and the lateral profiles of the MC simulation deviated from the measurements by 1% and 2%, respectively, on average. The computed simple MLC fields agreed with the EBT3 measurements with a 95% passing rate with 3%/3-mm gamma-index criterion. Additionally, in applying our model to clinical IMRT plans, we found that the MC calculations and the EBT3 measurements agreed well with a passing rate of greater

  17. Hudson County Community College Periodic Review Report. Executive Summary.

    ERIC Educational Resources Information Center

    Hudson County Community Coll., Jersey City, NJ.

    Hudson County Community College (HCCC) serves Hudson County, New Jersey. Although the county is the smallest in the state, its 610,000 residents make up one of the most diverse counties in New Jersey. Approximately 40% of residents are Hispanic, 12% are African-American, 10% are Asian, and 35% are White. The county is also home to a growing Middle…

  18. 32. Photocopy of original drawing in possession of the County ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Photocopy of original drawing in possession of the County Auditor, Johnson County, Iowa. PROFILE OF HIGHWAY BRIDGE OVER CEDAR RIVER AT SUTLIFF'S FERRY IN JOHNSON COUNTY, IOWA, 1897. (RIGHT 1/4 OF DRAWING) PLAN OF APPROACH FOR SUTLIFF'S FERRY BRIDGE OVER CEDAR RIVER, JOHNSON COUNTY, IOWA, 1897 - Sutliff's Ferry Bridge, Spanning Cedar River (Cedar Township), Solon, Johnson County, IA

  19. An investigation of several aspects of LANDSAT-5 data quality. [Palmer County, Shelby, mt; White sands, NM; Great Salt Lake, UT; San Matted Bridge and Sacramento, California

    NASA Technical Reports Server (NTRS)

    Wrigley, R. C. (Principal Investigator)

    1984-01-01

    Band-to-band registration, geodetic registration, interdector noise, and the modulation transfer function (MTE) are discussed for the Palmer County; TX scene. Band combinations for several LANDSAT 4 and LANDSAT 5 scenes; the geodetic registration test for the Sacramento, CA area; periodic noise components in TM band 5; and grey level measurements by detector for Great Salt Lake (UT) dark water forescans and backscans are considered. Results of MTF analyses of the San Mateo Bridge and of TM high resolution and aerial Daedalus scanner imagery are consistent and appear to be repeatable. An oil-on-sand target was constructed on the White Sands Missile Range in New Mexico. The two-image analysis procedure used is summarized.

  20. 78 FR 60686 - Establishment of the Big Valley District-Lake County and Kelsey Bench-Lake County Viticultural...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... District-Lake County and Kelsey Bench-Lake County Viticultural Areas and Modification of the Red Hills Lake... the boundary of the established 31,250-acre Red Hills Lake County viticultural area in order to align... boundary based on USGS map markings. Big Valley District-Lake County and Kelsey Bench-Lake County...

  1. Tourism Market Analysis: Cheyenne-Laramie County

    DTIC Science & Technology

    1986-04-01

    of a study prepared by the U.S. Travel Data Center in 1981. It found that tourism substantially contributes to Wyoming employment and income. Tourist...of the annual total in the county. Economic Impact of Tourism in Laramie County The 1981 study by U.S. Travel Commission breaks out the economic...implications of tourism by county. The methodology used in estimating eco- nomic impact likely results in overstating its benefits since anyone traveling

  2. Waste source reduction county government case study

    SciTech Connect

    1990-12-31

    Itasca County is located in north-central Minnesota, has a population of 42,000 and is known for its forests and scenic waterways. With Beltrami County, it contains the upper watershed of the Mississippi River. Its major industries are timber and tourism. Itasca County government made a commitment to source reduce its waste as much as possible. Secondarily, what they could not reduce they committed themselves to recycle. The project demonstrates functional reduction in practice. It shows that reduction is a realistic goal for county governments and that reduction can be measured on a waste stream by waste stream basis.

  3. Water resources of Lehigh County, Pennsylvania

    USGS Publications Warehouse

    Wood, Charles R.; Flippo, Herbert N.; Lescinsky, Joseph B.; Barker, James L.

    1972-01-01

    Lehigh County occupies an area of 347 square miles in southeastern Pennsylvania. The northern part of Lehigh County is underlain by the Martinsburg Formation, which consists chiefly of shale and slate. The central part of the county, where most of the population centers are located and much of the urbanization is occurring, is underlain by alternating beds of limestone and dolomite. From oldest to youngest, these carbonate rocks are the Leithsville Formation, the Allentown Formation, the Beekmantown Group, and the Jacksonburg Formation. The southern part of the county is underlain chiefly by the shales, sandstones, and conglomerates of the Brunswick Formation and by metamorphic and igneous rocks.

  4. 75 FR 25308 - Environmental Impact Statement: Winnebago County, IL and Rock County, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: Winnebago County, IL and Rock County, WI... Beloit, Rock County, Wisconsin to the interchange of Rockton Road and I-90 southeast of South...

  5. The Economic Impact of Schenectady County Community College on Schenectady County, 1981-82.

    ERIC Educational Resources Information Center

    Chestnut, Erma Ruth

    This report on the economic impact of Schenectady County Community College (SCCC) uses a modification of the Caffrey and Isaacs model to assess SCCC-related local business volume, SCCC costs and benefits to the Schenectady County government, and the likely impact on the county if SCCC did not exist. Part I provides background to the study,…

  6. 33 CFR 100.905 - Door County Triathlon; Door County, WI.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Door County Triathlon; Door... SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.905 Door County Triathlon; Door County, WI. (a) Regulated Area. A regulated area is established to include all waters of Green...

  7. 33 CFR 100.905 - Door County Triathlon; Door County, WI.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Door County Triathlon; Door... SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.905 Door County Triathlon; Door County, WI. (a) Regulated Area. A regulated area is established to include all waters of Green...

  8. 75 FR 26709 - Clarke County Water Supply Project, Clarke County, IA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Water Supply Project, Clarke County, IA AGENCY: Natural Resources Conservation Service. ACTION: Notice... environmental impact statement is being prepared for the Clarke County Water Supply Project, Clarke County, Iowa... related to water supply demand requirements for permitting by the State was discovered. This...

  9. 33 CFR 100.905 - Door County Triathlon; Door County, WI.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Door County Triathlon; Door County, WI. 100.905 Section 100.905 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.905 Door County...

  10. 33 CFR 100.905 - Door County Triathlon; Door County, WI.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Door County Triathlon; Door County, WI. 100.905 Section 100.905 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.905 Door County...

  11. 33 CFR 100.905 - Door County Triathlon; Door County, WI.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Door County Triathlon; Door County, WI. 100.905 Section 100.905 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.905 Door County...

  12. Digital computer processing of LANDSAT data for North Alabama. [Linestone County, Madison County, Jackson County, Marshall County, and DeKalb County

    NASA Technical Reports Server (NTRS)

    Bond, A. D.; Atkinson, R. J.; Lybanon, M.; Ramapriyan, H. K.

    1977-01-01

    Computer processing procedures and programs applied to Multispectral Scanner data from LANDSAT are described. The output product produced is a level 1 land use map in conformance with a Universal Transverse Mercator projection. The region studied was a five-county area in north Alabama.

  13. 6. Photocopy of illustration on Map of Chester County Pennsylvania, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photocopy of illustration on Map of Chester County Pennsylvania, by T.J. Kennedy, published by R.L. Barnes, Philadelphia, Pennsylvania, 1856 SOUTHWEST CORNER, 1856 - Bank of Chester County, 17 North High Street, West Chester, Chester County, PA

  14. 75 FR 54419 - Environmental Impact Statement: Yellowstone County, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... Federal Highway Administration Environmental Impact Statement: Yellowstone County, MT AGENCY: Federal... highway project in Yellowstone County, Montana. FOR FURTHER INFORMATION CONTACT: Brian Hasselbach, Right... (I-90) and Old Highway 312 in or near the city of Billings, Yellowstone County, Montana....

  15. Characterization of Vadose Zone Sediments Below the TX Tank Farm: Boreholes C3830, C3831, C3832 and RCRA Borehole 299-W10-27

    SciTech Connect

    Serne, R. Jeffrey; Bjornstad, Bruce N.; Horton, Duane G.; Lanigan, David C.; Lindenmeier, Clark W.; Lindberg, Michael J.; Clayton, Ray E.; Legore, Virginia L.; Orr, Robert D.; Kutnyakov, Igor V.; Baum, Steven R.; Geiszler, Keith N.; Valenta, Michelle M.; Vickerman, Tanya S.

    2008-09-11

    This report was revised in September 2008 to remove acid-extractable sodium data from Tables 4.8, 4.28,4.43, and 4.59. The sodium data was removed due to potential contamination introduced during the acid extraction process. The rest of the text remains unchanged from the original report issued in April 2004. The overall goal of the Tank Farm Vadose Zone Project, led by CH2M HILL Hanford Group, Inc., is to define risks from past and future single-shell tank farm activities at Hanford. To meet this goal, CH2M HILL Hanford Group, Inc. tasked scientists from Pacific Northwest National Laboratory to perform detailed analyses on vadose zone sediments from within Waste Management Area (WMA) T-TX-TY. This report is the first of two reports written to present the results of these analyses. Specifically, this report contains all the geologic, geochemical, and selected physical characterization data collected on vadose zone sediment recovered from boreholes C3830, C3831, and C3832 in the TX Tank Farm, and from borehole 299-W-10-27 installed northeast of the TY Tank Farm.

  16. Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.

    PubMed

    Murray, Justin K; Long, Jason; Zou, Anruo; Ligutti, Joseph; Andrews, Kristin L; Poppe, Leszek; Biswas, Kaustav; Moyer, Bryan D; McDonough, Stefan I; Miranda, Les P

    2016-03-24

    There is interest in the identification and optimization of new molecular entities selectively targeting ion channels of therapeutic relevance. Peptide toxins represent a rich source of pharmacology for ion channels, and we recently reported GpTx-1 analogs that inhibit NaV1.7, a voltage-gated sodium ion channel that is a compelling target for improved treatment of pain. Here we utilize multi-attribute positional scan (MAPS) analoging, combining high-throughput synthesis and electrophysiology, to interrogate the interaction of GpTx-1 with NaV1.7 and related NaV subtypes. After one round of MAPS analoging, we found novel substitutions at multiple residue positions not previously identified, specifically glutamic acid at positions 10 or 11 or lysine at position 18, that produce peptides with single digit nanomolar potency on NaV1.7 and 500-fold selectivity against off-target sodium channels. Docking studies with a NaV1.7 homology model and peptide NMR structure generated a model consistent with the key potency and selectivity modifications mapped in this work.

  17. Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1

    PubMed Central

    Joeres, Niko; Augustinowski, Katrin; Neuhof, Andreas; Assmann, Marc; Gründer, Stefan

    2016-01-01

    Acid Sensing Ion Channels (ASICs) detect extracellular proton signals and are involved in synaptic transmission and pain sensation. ASIC subunits assemble into homo- and heteromeric channels composed of three subunits. Single molecule imaging revealed that heteromers composed of ASIC1a and ASIC2a, which are widely expressed in the central nervous system, have a flexible 2:1/1:2 stoichiometry. It was hitherto not possible, however, to functionally differentiate these two heteromers. To have a homogenous population of ASIC1a/2a heteromers with either 2:1 or 1:2 stoichiometry, we covalently linked subunits in the desired configuration and characterized their functional properties in Xenopus oocytes. We show that the two heteromers have slightly different proton affinity, with an additional ASIC1a subunit increasing apparent affinity. Moreover, we found that zinc, which potentiates ASIC2a-containing ASICs but not homomeric ASIC1a, potentiates both heteromers. Finally, we show that PcTx1, which binds at subunit-subunit interfaces of homomeric ASIC1a, inhibits both heteromers suggesting that ASIC2a can also contribute to a PcTx1 binding site. Using this functional fingerprint, we show that rat cortical neurons predominantly express the ASIC1a/2a heteromer with a 2:1 stoichiometry. Collectively, our results reveal the contribution of individual subunits to the functional properties of ASIC1a/2a heteromers. PMID:27277303

  18. Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.

    PubMed

    Smith, Jaime J; Cummins, Theodore R; Alphy, Sujith; Blumenthal, Kenneth M

    2007-04-27

    Voltage-gated Na(+) channels are critical components in the generation of action potentials in excitable cells, but despite numerous structure-function studies on these proteins, their gating mechanism remains unclear. Peptide toxins often modify channel gating, thereby providing a great deal of information about these channels. ProTx-II is a 30-amino acid peptide toxin from the venom of the tarantula, Thrixopelma pruriens, that conforms to the inhibitory cystine knot motif and which modifies activation kinetics of Na(v) and Ca(v), but not K(v), channels. ProTx-II inhibits current by shifting the voltage dependence of activation to more depolarized potentials and, therefore, differs from the classic site 4 toxins that shift voltage dependence of activation in the opposite direction. Despite this difference in functional effects, ProTx-II has been proposed to bind to neurotoxin site 4 because it modifies activation. Here, we investigate the bioactive surface of ProTx-II by alanine-scanning the toxin and analyzing the interactions of each mutant with the cardiac isoform, Na(v)1.5. The active face of the toxin is largely composed of hydrophobic and cationic residues, joining a growing group of predominantly K(v) channel gating modifier toxins that are thought to interact with the lipid environment. In addition, we performed extensive mutagenesis of Na(v)1.5 to locate the receptor site with which ProTx-II interacts. Our data establish that, contrary to prior assumptions, ProTx-II does not bind to the previously characterized neurotoxin site 4, thus making it a novel probe of activation gating in Na(v) channels with potential to shed new light on this process.

  19. 76 FR 28415 - Fresno County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Robbin Ekman, Fresno County Resource Advisory Committee Coordinator, c/ o Sierra National Forest, High... FURTHER INFORMATION CONTACT: Robbin Ekman, Fresno County Resource ] Advisory Committee Coordinator,...

  20. 76 FR 44302 - Fresno County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... Robbin Ekman, Fresno County Resource Advisory Committee Coordinator, c/ o Sierra National Forest, High... FURTHER INFORMATION CONTACT: Robbin Ekman, Fresno County Resource Advisory Committee Coordinator,...

  1. 7. Photocopy of photograph (from Broome County Historical Society) showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of photograph (from Broome County Historical Society) showing SWIMMERS, PHOTOGRAPH TAKEN FACING NORTHEAST - Charles F. Johnson Pool, Charles F. Johnson Park, Johnson City, Broome County, NY

  2. Landsliding in Allegheny County, Pennsylvania

    USGS Publications Warehouse

    Briggs, Reginald Peter; Pomeroy, John S.; Davies, William E.

    1975-01-01

    Man should proceed with caution if modifications such as loading, excavation, or changes of the water regime are contemplated for slopes in Allegheny County, especially those slopes described on the map as highly sensitive to disturbance by man. Features indicative of unstable slope conditions include: cracks in buildings, yard walls, and pools; doors and windows that jam; fences and other linear features bowed out of line; tilted trees and utility poles; cracks and steplike ground features; hummocky ground; and water seeps. Geologic factors related to the landsliding process include rock types, layering, fracturing, and attitude; nature of soil cover; permeability of rocks and soils; and steepness of slope.

  3. Water resources of Sweetwater County, Wyoming

    USGS Publications Warehouse

    Mason, Jon P.; Miller, Kirk A.

    2004-01-01

    Sweetwater County is located in the southwestern part of Wyoming and is the largest county in the State. A study to quantify the availability and describe the chemical quality of surface-water and ground-water resources in Sweetwater County was conducted by the U.S. Geological Survey in cooperation with the Wyoming State Engineers Office. Most of the county has an arid climate. For this reason a large amount of the flow in perennial streams within the county is derived from outside the county. Likewise, much of the ground-water recharge to aquifers within the county is from flows into the county, and occurs slowly. Surface-water data were not collected as part of the study. Evaluations of streamflow and stream-water quality were limited to analyses of historical data and descriptions of previous investigations. Forty-six new ground-water-quality samples were collected as part of the study and the results from an additional 782 historical ground-water-quality samples were reviewed. Available hydrogeologic characteristics for various aquifers throughout the county also are described. Flow characteristics of streams in Sweetwater County vary substantially depending on regional and local basin characteristics and anthropogenic factors. Because precipitation amounts in the county are small, most streams in the county are ephemeral, flowing only as a result of regional or local rainfall or snowmelt runoff. Flows in perennial streams in the county generally are a result of snowmelt runoff in the mountainous headwater areas to the north, west, and south of the county. Flow characteristics of most perennial streams are altered substantially by diversions and regulation. Water-quality characteristics of selected streams in and near Sweetwater County during water years 1974 through 1983 were variable. Concentrations of dissolved constituents, suspended sediment, and bacteria generally were smallest at sites on the Green River because of resistant geologic units, increased

  4. Effect of alkyl chain of room temperature ionic liquid (RTILs) on the phase behavior of [C2mim][C(n)SO4]/TX-100/cyclohexane microemulsions: solvent and rotational relaxation study.

    PubMed

    Ghosh, Surajit; Banerjee, Chiranjib; Mandal, Sarthak; Rao, Vishal Govind; Sarkar, Nilmoni

    2013-05-16

    In this investigation, we present microemulsions comprising a nonionic surfactant, Triton X-100 (TX-100), cyclohexane as nonpolar phase, and room temperature ionic liquids (RTILs) as a polar medium. To investigate the effect of alkyl chain length of ionic liquid on the physicochemical properties of microemulsions, we have used 1-ethyl-3-methylimidazolium n-butyl sulfate [C2mim][C4SO4], 1-ethyl-3-methylimidazolium n-hexyl sulfate [C2mim][C6SO4], and 1-ethyl-3-methylimidazolium n-octyl sulfate [C2mim][C8SO4] as polar media. The phase behavior of these ternary systems is investigated by direct observation of transition from clear transparent solution to turbid solution by using UV-vis spectrophotometer at 298 K. The single-phase region is found to increase with increase in chain length of RTIL anion. Dynamic light scattering (DLS) measurements revealed the formation of highly stable nano-sized RTIL-containing microemulsions. The size of the microemulsions increases with the addition of ionic liquid. The maximum increase in size is observed with the addition of [C2mim][C4SO4]. It is proposed that the long octyl chain of octyl sulfate allows the anion to align itself along the TX-100 molecules which increases the rigidity of microemulsions, whereas in case of [C2mim][C4SO4], the short butyl chain is apparently unable to do the same. The dynamics of solvent and rotational relaxation of coumarin 480 (C-480) has also been investigated in these ionic liquid containing microemulsions ([C2mim][C4SO4]/TX-100/cyclohexane, [C2mim][C6SO4]/TX-100/cyclohexane, and [C2mim][C8SO4]/TX-100/cyclohexane) using picosecond time-resolved fluorescence spectroscopy. In RTIL microemulsions, solvent relaxation becomes retarded compared to neat RTIL. We have also shown that with increasing R value, the solvation dynamics becomes faster and the decrease in average solvation time is more pronounced in [C2mim][C4SO4]/TX-100/cyclohexane compared to [C2mim][C6SO4]/TX-100/cyclohexane and [C2mim][C8SO4

  5. A Profile of Suwannee County, Florida.

    ERIC Educational Resources Information Center

    Beaulieu, Lionel J.

    Agriculture and the railroad were significant forces in the development of Suwannee County, Florida, formally created in 1858 but explored and settled beginning some 300 years earlier. Lumber and cotton caused an early 20th century boom in the county which soon saw the negative effects of both industries. The introduction of tobacco in the late…

  6. County Data Book 1995: Kentucky Kids Count.

    ERIC Educational Resources Information Center

    Kentucky Youth Advocates, Inc., Louisville.

    This data book presents findings of the Kids Count project on current conditions faced by Kentucky children age birth through 19. For each county, and for the state, comparisons are provided between the base years of 1980-1982 and the most recent years 1992-1994. Counties are ranked against each other and trend graphs are provided for the studied…

  7. Educational and Demographic Profile: Contra Costa County.

    ERIC Educational Resources Information Center

    California Postsecondary Education Commission, 2004

    2004-01-01

    This profile uniquely presents a variety of educational and socioeconomic information for Contra Costa County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

  8. 24 CFR 570.307 - Urban counties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... activities, specifically urban renewal and publicly assisted housing. In determining whether a county has the... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Urban counties. 570.307 Section 570.307 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  9. 24 CFR 570.307 - Urban counties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... activities, specifically urban renewal and publicly assisted housing. In determining whether a county has the... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Urban counties. 570.307 Section 570.307 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  10. 24 CFR 570.307 - Urban counties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... activities, specifically urban renewal and publicly assisted housing. In determining whether a county has the... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Urban counties. 570.307 Section 570.307 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  11. 24 CFR 570.307 - Urban counties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... activities, specifically urban renewal and publicly assisted housing. In determining whether a county has the... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Urban counties. 570.307 Section 570.307 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  12. Socioeconomic Heterogeneity of Mining-Dependent Counties.

    ERIC Educational Resources Information Center

    Nord, Mark; Luloff, A. E.

    1993-01-01

    Although the socioeconomic well-being of all U.S. mining-dependent counties was slightly above the national average in 1990, disaggregation reveals substantial effects of region and mining subsector. In particular, southern and Great Lakes coal-mining counties had significantly lower high school graduation rates and higher poverty and unemployment…

  13. LANE COUNTY YOUTH PROJECT. FINAL REPORT.

    ERIC Educational Resources Information Center

    BREWER, EDGAR W.; AND OTHERS

    A GROUP OF LANE COUNTY, OREGON, CITIZENS WHO WERE CONCERNED ABOUT JUVENILE DELINQUENCY BANDED TOGETHER IN 1962 TO ESTABLISH THE LANE COUNTY YOUTH PROJECT (LCYP). THE PRIMARY PURPOSE OF LCYP WAS TO PLAN A MAJOR DEMONSTRATION PROJECT AIMED AT THE PREVENTION AND CONTROL OF DELINQUENCY AND RELATED YOUTH PROBLEMS IN BOTH RURAL AND SMALL CITY SETTINGS.…

  14. Educational and Demographic Profile: Lake County.

    ERIC Educational Resources Information Center

    California Postsecondary Education Commission, 2004

    2004-01-01

    This profile uniquely presents a variety of educational and socioeconomic information for Lake County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

  15. Tennessee County Higher Education Profiles, 2010

    ERIC Educational Resources Information Center

    Tennessee Higher Education Commission, 2010

    2010-01-01

    The "Tennessee County Higher Education Profiles 2010" provide basic information with respect to higher education for each county in Tennessee. The 2010 "Profiles" represent the fourth year for this report. In the demographic and enrollment sections, a few changes were made to better meet the needs of policymakers. This document…

  16. Groundwater management and protection Madison County, Alabama

    SciTech Connect

    French, J.H.; Strunk, J.W.

    1990-07-01

    Groundwater is extremely important to Madison County as it provides nearly three quarters of the county's drinking water. In recent years, Madison County has increasingly recognized the need to protect its groundwater resource. A supply of usable groundwater is one element of a high quality environment, which can help spur economic development and provide for the needs of a growing population. Without planning protection and understanding of possible consequences, however, economic development and population pressures can cause a gradual degradation of groundwater. In April 1987, the Tennessee Valley Authority (TVA) convened a local groundwater steering group in Madison County. At the first meeting the ground agreed upon these goals: (1) to seek incorporate groundwater protection into the planning and development process for Madison County, (2) to support efforts by Madison County to obtain authority to adopt zoning ordinances and subdivision regulations, and (3) to develop a groundwater management plan for the county. This report provides essential information needed in developing a plan and is based on the following assumptions: the citizens of Madison County value the environment in which they live and wish to protect it from pollution; continued economic development is necessary for a healthy local economy; and a healthy economy can be sustained and nurtured, without degradation of the groundwater resource, through countywide planning, education, and participation.

  17. Educational and Demographic Profile: El Dorado County

    ERIC Educational Resources Information Center

    California Postsecondary Education Commission, 2004

    2004-01-01

    This profile uniquely presents a variety of educational and socioeconomic information for El Dorado County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

  18. The Farm Crisis and Decatur County.

    ERIC Educational Resources Information Center

    Flora, Jan L.; And Others

    This case study assesses the impact of the farm sector on the economy and social organization of Decatur County (Kansas), a county which has historically depended on agriculture for its livelihood. Data were obtained from analysis of time series statistical indicators for the period between 1966 and 1984, questionnaire responses of local…

  19. Commodity Flow Study - Clark County, Nevada, USA

    SciTech Connect

    Conway, S.Ph.D.; Navis, I.

    2008-07-01

    The United States Department of Energy has designated Clark County, Nevada as an 'Affected Unit of Local Government' due to the potential for impacts by activities associated with the Yucca Mountain High Level Nuclear Waste Repository project. Urban Transit, LLC has led a project team of transportation including experts from the University of Nevada Las Vegas Transportation Research Center to conduct a hazardous materials community flow study along Clark County's rail and truck corridors. In addition, a critical infrastructure analysis has also been carried out in order to assess the potential impacts of transportation within Clark County of high level nuclear waste and spent nuclear fuel to a proposed repository 90 miles away in an adjacent county on the critical infrastructure in Clark County. These studies were designed to obtain information relating to the transportation, identification and routing of hazardous materials through Clark County. Coordinating with the United States Department of Energy, the U.S. Department of Agriculture, the U. S. Federal Highway Administration, the Nevada Department of Transportation, and various other stakeholders, these studies and future research will examine the risk factors along the entire transportation corridor within Clark County and provide a context for understanding the additional vulnerability associated with shipping spent fuel through Clark County. (authors)

  20. A Profile of Hardee County, Florida.

    ERIC Educational Resources Information Center

    Beaulieu, Lionel J.; Anderson, Deborah S.

    In 1977 leaders of Hardee County, Florida, listed relationships and attitudes of residents, rural atmosphere, environmental conditions, and economic potential among the county's strong points, and public service and facility improvements, developing economic potential, recreational and entertainment development, and planning and zoning as its most…

  1. Geothermal development issues: Recommendations to Deschutes County

    SciTech Connect

    Gebhard, C.

    1982-07-01

    This report discusses processes and issues related to geothermal development. It is intended to inform planners and interested individuals in Deschutes County about geothermal energy, and advise County officials as to steps that can be taken in anticipation of resource development. (ACR)

  2. Analysis of County School Districts in Arkansas.

    ERIC Educational Resources Information Center

    Budd, Karol B.; Charlton, J.L.

    The 1948, Arkansas School District Reorganization Act was passed in an effort to reduce the 1589 small school districts to a smaller number. Those districts not consolidated would form county districts. As of the 1967-68 school year, 26 of these county districts remained. The purpose of this study was to provide information drawing attention to…

  3. Educational and Demographic Profile: Napa County.

    ERIC Educational Resources Information Center

    California Postsecondary Education Commission, 2004

    2004-01-01

    This profile uniquely presents a variety of educational and socioeconomic information for Napa County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

  4. A Profile of Anson County, North Carolina.

    ERIC Educational Resources Information Center

    Farr, M. Gaston; And Others

    Since 1950 Anson County, North Carolina, has had major contributions to economic development, a source of great concern to residents of the almost entirely rural area. The increased capacity of the Blewitt Falls Dam power output and the county-wide water filtration system (one of only a few in the United States today) are attractive to industry.…

  5. Public Library Service for San Benito County.

    ERIC Educational Resources Information Center

    McGovern, Gail

    A sparsely populated, agricultural area, San Benito County (California) provides library services in conjunction with the Hollister city library and in cooperation with the San Juan Bautista city library. Financing comes from the county general fund. There are no written goals or policy statements and no professionally trained librarians. As…

  6. [A Profile of Kershaw County, South Carolina].

    ERIC Educational Resources Information Center

    Lilley, Stephen C.; McLean, Edward L.

    Careful long-range planning and slow, deliberate growth have benefitted Kershaw County's 500,000 pleasantly varied acres near the state capitol. The county, famous for its equestrian activity, boasts prestige stables, riding clubs, and trails. In addition there are lakes and numerous parks. Leaders want to maintain this aesthetic appeal while…

  7. County Data Book 1997: Kentucky Kids Count.

    ERIC Educational Resources Information Center

    Kentucky Kids Count Consortium.

    This Kids Count data book examines trends in the well-being of Kentucky's children on a statewide and county basis. An introduction summarizes some of the trends for Kentucky's children in the 1990s. The bulk of the report presents statewide and county data grouped into five categories: (1) poverty rates and programs (persons in poverty; median…

  8. Environmental assessment: Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

  9. Imperial County geothermal development annual meeting: summary

    SciTech Connect

    Not Available

    1983-01-01

    All phases of current geothermal development in Imperial County are discussed and future plans for development are reviewed. Topics covered include: Heber status update, Heber binary project, direct geothermal use for high-fructose corn sweetener production, update on county planning activities, Brawley and Salton Sea facility status, status of Imperial County projects, status of South Brawley Prospect 1983, Niland geothermal energy program, recent and pending changes in federal procedures/organizations, plant indicators of geothermal fluid on East Mesa, state lands activities in Imperial County, environmental interests in Imperial County, offshore exploration, strategic metals in geothermal fluids rebuilding of East Mesa Power Plant, direct use geothermal potential for Calipatria industrial Park, the Audubon Society case, status report of the Cerro Prieto geothermal field, East Brawley Prospect, and precision gravity survey at Heber and Cerro Prieto geothermal fields. (MHR)

  10. Family planning in Nangong County.

    PubMed

    Sun, X

    1980-04-01

    Family planning has been practiced in Nangong county, China, since 1971; as a result the population growth rate has dropped from 16.7/1000 to 3.6/1000 in 1979; 98% of women of childbearing age use contraception, and most couples have only 1 child. Before 1971 most couples had 4-5 children; per capita grain rations had to be reduced because of the increase in population, and more grain had to be supplied by the state. 1 child families are now rewarded with an annual monetary bonus, extra grain allocations for the child, free tuition in schools, and preference in job placement and medical treatment. Parents who have more than 2 children are penalized by the withdrawal of 10% of their monthly earnings. The idea of "1 couple 1 child" is a radical change from China's traditional culture, which viewed children especially sons, as an insurance against old age insecurity. Marriage at a later age is also encouraged; in Nangong county none of the men of marriageable age married before 25, and none of the women before 23. As a result of promoting family planning Nangong country has ceased to need grain subsidies from the state, and in recent years has had a 10,000 ton surplus to sell.

  11. Fayette County Better Buildings Initiative

    SciTech Connect

    Capella, Arthur

    2015-03-04

    The Fayette County Better Buildings Initiative represented a comprehensive and collaborative approach to promoting and implementing energy efficiency improvements. The initiative was designed to focus on implementing energy efficiency improvements in residential units, while simultaneously supporting general marketing of the benefits of implementing energy efficiency measures. The ultimate goal of Fayette County’s Better Buildings Initiative was to implement a total of 1,067 residential energy efficiency retrofits with a minimum 15% estimated energy efficiency savings per unit. Program partners included: United States Department of Energy, Allegheny Power, and Private Industry Council of Westmoreland-Fayette, Fayette County Redevelopment Authority, and various local partners. The program was open to any Fayette County residents who own their home and meet the prequalifying conditions. The level of assistance offered depended upon household income and commitment to undergo a BPI – Certified Audit and implement energy efficiency measures, which aimed to result in at least a 15% reduction in energy usage. The initiative was designed to focus on implementing energy efficiency improvements in residential units, while simultaneously supporting general marketing of the benefits of implementing energy efficiency measures. Additionally, the program had components that involved recruitment and training for employment of persons in the energy sector (green jobs), as well as marketing and implementation of a commercial or community facilities component. The residential component of Fayette County’s Better Buildings Initiative involved a comprehensive approach, providing assistance to low- moderate- and market-rate homeowners. The initiative will also coordinate activities with local utility providers to further incentivize energy efficiency improvements among qualifying homeowners. The commercial component of Fayette County’s Better Building Initiative involved grants

  12. Characterization of Vadose Zone Sediments Below the TX Tank Farm: Probe Holes C3830, C3831, C3832 and 299-W10-27

    SciTech Connect

    Serne, R JEFFREY.; Bjornstad, Bruce N.; Horton, Duane G.; Lanigan, David C.; Lindenmeier, Clark W.; Lindberg, Michael J.; Clayton, Ray E.; LeGore, Virginia L.; Orr, Robert D.; Kutnyakov, Igor V.; Baum, Steven R.; Geiszler, Keith N.; Valenta, Michelle M.; Vickerman, Tanya S.

    2004-04-01

    Pacific Northwest National Laboratory performed detailed analyses on vadose zone sediments from within Waste Management Area T-TX-TY. This report contains all the geologic, geochemical, and selected physical characterization data collected on vadose zone sediment recovered from three probe holes (C3830, C3831, and C3832) in the TX Tank Farm, and from borehole 299-W-10-27. Sediments from borehole 299-W-10-27 are considered to be uncontaminated sediments that can be compared with contaminated sediments. This report also presents our interpretation of the sediment lithologies, the vertical extent of contamination, the migration potential of the contaminants, and the likely source of the contamination in the vadose zone and groundwater below the TX Tank Farm. Sediment from the probe holes was analyzed for: moisture, radionuclide and carbon contents;, one-to-one water extracts (soil pH, electrical conductivity, cation, trace metal, and anion data), and 8 M nitric acid extracts. Overall, our analyses showed that common ion exchange is a key mechanism that influences the distribution of contaminants within that portion of the vadose zone affected by tank liquor. We did not observe significant indications of caustic alteration of the sediment mineralogy or porosity, or significant zones of slightly elevated pH values in the probe holes. The sediments do show that sodium-, nitrate-, and sulfate-dominated fluids are present. The fluids are more dilute than tank fluids observed below tanks at the SX and BX Tank Farms. Three primary stratigraphic units were encountered in each probe hole: (1) backfill material, (2) the Hanford formation, and (3) the Cold Creek unit. Each of the probe holes contain thin fine-grained layers in the Hanford H2 stratigraphic unit that may impact the flow of leaked fluids and effect irregular and horizontal flow. The probe holes could not penetrate below the enriched calcium carbonate strata of the Cold Creek lower subunit; therefore, we did not

  13. Guiding Surge Reduction Strategies via Characterization of Coastal Surge Propagation and Internal Surge Generation within a Complex Bay/Estuary System, Galveston Bay, TX

    NASA Astrophysics Data System (ADS)

    Bass, B.; Torres, J.; Irza, N.; Bedient, P. B.; Dawson, C.; Proft, J.

    2015-12-01

    In this study, Hurricane Ike (2008) and a suite of synthetic storms are simulated in order to evaluate how different hurricane landfalls, wind intensities, and radius to maximum winds influence the surge response in complex semi-enclosed bays such as Galveston Bay, located along the Texas Gulf Coast. The Advanced CIRCulation and Simulating Waves Nearshore (ADCIRC+SWAN) models are employed to quantify surge in terms of its relative coastal contributions that propagate across barrier islands and tidal inlets and subsequently into Galveston Bay, the surge generated locally within the Bay itself, and the interaction between these coastal and local components of surge. Results from this research will further the current understanding of surge interactions in bay systems and guide coastal engineering surge reduction projects that need to consider multiple lines of defense to protect complex bay/estuary systems such as Galveston Bay, TX.

  14. Evaluation of the Union County Alternative to Suspension Program

    ERIC Educational Resources Information Center

    Dunlap, Joyce Ann

    2010-01-01

    The schools in Union County have undergone a tremendous amount of growth in the past decade. The growth in the county has led to an increase in discipline problems. In order to provide suspended students a second chance, Union County Public Schools implemented an alternative to suspension program, the Union County Alternative to Suspension Program…

  15. 7 CFR 7.11 - County committee members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false County committee members. 7.11 Section 7.11... CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.11 County committee members. (a) County committee members elected in accordance with § 7.9 of this part shall hold office for a term of three years or...

  16. The utility of Geographical Information Systems (GIS) in systems-oriented obesity intervention projects: The selection of comparable study sites for a quasi-experimental intervention design--TX CORD

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Texas Childhood Obesity Research Demonstration project (TX CORD) uses a systems-oriented approach to address obesity that includes individual and family interventions, community-level action, as well as environmental and policy initiatives. Given that randomization is seldom possible in communit...

  17. The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.

    PubMed

    Gonçaves, Jomara M; Ferreira, Juliano; Prado, Marco Antonio M; Cordeiro, Marta N; Richardson, Michael; Pinheiro, Ana Cristina do Nascimento; Silva, Marco A Romano; Junior, Celio José de Castro; Souza, Alessandra H; Gomez, Marcus Vinicius

    2011-03-01

    In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin MVIIA and xconotoxin MVIIC, only inhibited calcium-dependent glutamate release. PhTx3-4, but not ω-conotoxin MVIIA or xconotoxin MVIIC, is able to inhibit the uptake of glutamate by synaptosomes, and this inhibition in turn leads to a decrease in the Ca(2+)-independent release of glutamate. No other polypeptide toxin so far described has this effect. PhTx3-4 and ω-conotoxins MVIIC and MVIIA are blockers of voltage-dependent calcium channels, and they significantly inhibited the capsaicin-induced rise of intracellular calcium [Ca(2+)](i) in spinal cord synaptosomes, which likely reflects calcium entry through voltage-gated calcium channels. The inhibition of the calcium-independent glutamate release by PhTx3-4 suggests a potential use of the toxin to block abnormal glutamate release in pathological conditions such as pain.

  18. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

    PubMed

    Deuis, Jennifer R; Wingerd, Joshua S; Winter, Zoltan; Durek, Thomas; Dekan, Zoltan; Sousa, Silmara R; Zimmermann, Katharina; Hoffmann, Tali; Weidner, Christian; Nassar, Mohammed A; Alewood, Paul F; Lewis, Richard J; Vetter, Irina

    2016-03-17

    Loss-of-function mutations of Na(V)1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of Na(V)1.7 a promising therapeutic strategy for the treatment of pain. We characterized a novel mouse model of Na(V)1.7-mediated pain based on intraplantar injection of the scorpion toxin OD1, which is suitable for rapid in vivo profiling of Na(V)1.7 inhibitors. Intraplantar injection of OD1 caused spontaneous pain behaviors, which were reversed by co-injection with Na(V)1.7 inhibitors and significantly reduced in Na(V)1.7(-/-) mice. To validate the use of the model for profiling Na(V)1.7 inhibitors, we determined the Na(V) selectivity and tested the efficacy of the reported Na(V)1.7 inhibitors GpTx-1, PF-04856264 and CNV1014802 (raxatrigine). GpTx-1 selectively inhibited Na(V)1.7 and was effective when co-administered with OD1, but lacked efficacy when delivered systemically. PF-04856264 state-dependently and selectively inhibited Na(V)1.7 and significantly reduced OD1-induced spontaneous pain when delivered locally and systemically. CNV1014802 state-dependently, but non-selectively, inhibited Na(V) channels and was only effective in the OD1 model when delivered systemically. Our novel model of Na(V)1.7-mediated pain based on intraplantar injection of OD1 is thus suitable for the rapid in vivo characterization of the analgesic efficacy of Na(V)1.7 inhibitors.

  19. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

    PubMed Central

    Deuis, Jennifer R.; Wingerd, Joshua S.; Winter, Zoltan; Durek, Thomas; Dekan, Zoltan; Sousa, Silmara R.; Zimmermann, Katharina; Hoffmann, Tali; Weidner, Christian; Nassar, Mohammed A.; Alewood, Paul F.; Lewis, Richard J.; Vetter, Irina

    2016-01-01

    Loss-of-function mutations of NaV1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of NaV1.7 a promising therapeutic strategy for the treatment of pain. We characterized a novel mouse model of NaV1.7-mediated pain based on intraplantar injection of the scorpion toxin OD1, which is suitable for rapid in vivo profiling of NaV1.7 inhibitors. Intraplantar injection of OD1 caused spontaneous pain behaviors, which were reversed by co-injection with NaV1.7 inhibitors and significantly reduced in NaV1.7−/− mice. To validate the use of the model for profiling NaV1.7 inhibitors, we determined the NaV selectivity and tested the efficacy of the reported NaV1.7 inhibitors GpTx-1, PF-04856264 and CNV1014802 (raxatrigine). GpTx-1 selectively inhibited NaV1.7 and was effective when co-administered with OD1, but lacked efficacy when delivered systemically. PF-04856264 state-dependently and selectively inhibited NaV1.7 and significantly reduced OD1-induced spontaneous pain when delivered locally and systemically. CNV1014802 state-dependently, but non-selectively, inhibited NaV channels and was only effective in the OD1 model when delivered systemically. Our novel model of NaV1.7-mediated pain based on intraplantar injection of OD1 is thus suitable for the rapid in vivo characterization of the analgesic efficacy of NaV1.7 inhibitors. PMID:26999206

  20. In-situ Measurements of Ozone Production Rates and Comparisons to Model-derived Production Rates During the Houston, TX and Denver, CO DISCOVER-AQ Campaigns

    NASA Astrophysics Data System (ADS)

    Baier, B. C.; Brune, W. H.; Miller, D. O.; Lefer, B. L.

    2015-12-01

    Tropospheric ozone (O3) is a secondary pollutant that has harmful effects on human and plant life. The climate and urban emissions in Houston, TX and Denver, CO can be conducive for significant ozone production and thus, high ozone events. Tighter government strategies for ozone mitigation have been proposed, which involve reducing the current EPA eight-hour ozone standard from 75 ppb to 65-70 ppb. These strategies rely on the reduction of ozone precursors in order to decrease the ozone production rate, P(O3). The changes in the ozone concentration at a certain location are dependent upon P(O3), so decreasing P(O3) can decrease ozone levels provided that it has not been transported from other areas. Air quality models test reduction strategies before they are implemented, locate ozone sources, and predict ozone episodes. Traditionally, P(O3) has been calculated by models. However, large uncertainties in model emissions inventories, chemical mechanisms, and meteorology can reduce confidence in this approach. A new instrument, the Measurement of Ozone Production Sensor (MOPS) directly measures P(O3) and can provide an alternate approach to determining P(O3). An updated version of the Penn State MOPS (MOPSv2.0) was deployed to Houston, TX and Denver, CO as a part of NASA's DISCOVER-AQ field campaign in the summers of 2013 and 2014, respectively. We present MOPS directly-measured P(O3) rates from these areas, as well as comparisons to zero-dimensional and three-dimensional modeled P(O3) using the RACM2 and MCMv2.2 mechanisms. These comparisons demonstrate the potential of the MOPS to test and evaluate model-derived P(O3), to advance the understanding of model chemical mechanisms, and to improve predictions of high ozone events.